# geneInfo

ensembl_gene_id: ANME2D_00011
symbol: glnA-2
gene_biotype: protein_coding
description:
  PFAM: Glutamine synthetase, catalytic domain; Glutamine synthetase, beta-Grasp domain; TIGRFAM: glutamine synthetase, type I.


ensembl_gene_id: ANME2D_00015
symbol: KCZ72957.1
gene_biotype: protein_coding
description:
  Helicase family protein with metal-binding cysteine cluster; PFAM: Helicase conserved C-terminal domain; Domain of unknown function (DUF1998); DEAD/DEAH box helicase.


ensembl_gene_id: ANME2D_00019
symbol: KCZ72961.1
gene_biotype: protein_coding
description:
  ABC-type uncharacterized transport system, permease component; PFAM: Uncharacterised protein family (UPF0014); TIGRFAM: TIGR00245 family protein.


ensembl_gene_id: ANME2D_00029
symbol: KCZ72971.1
gene_biotype: protein_coding
description:
  PAS domain S-box; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Response regulator receiver domain; His Kinase A (phospho-acceptor) domain; PAS fold; TIGRFAM: PAS domain S-box.


ensembl_gene_id: ANME2D_00033
symbol: KCZ72975.1
gene_biotype: protein_coding
description:
  PAS domain S-box; PFAM: Response regulator receiver domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; GAF domain; His Kinase A (phospho-acceptor) domain; PAS fold; TIGRFAM: PAS domain S-box.


ensembl_gene_id: ANME2D_00038
symbol: crtE
gene_biotype: protein_coding
description:
  Geranylgeranyl pyrophosphate synthase; PFAM: Polyprenyl synthetase; Belongs to the FPP/GGPP synthase family.


ensembl_gene_id: ANME2D_00045
symbol: KCZ72986.1
gene_biotype: protein_coding
description:
  PFAM: Uncharacterized protein conserved in archaea (DUF2099); TIGRFAM: putative methanogenesis marker protein 8.


ensembl_gene_id: ANME2D_00049
symbol: serA
gene_biotype: protein_coding
description:
  PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; TIGRFAM: D-3-phosphoglycerate dehydrogenase.


ensembl_gene_id: ANME2D_00050
symbol: KCZ72991.1
gene_biotype: protein_coding
description:
  Aspartate kinase; PFAM: ACT domain; Amino acid kinase family; TIGRFAM: aspartate kinase, monofunctional class; aspartate kinase; Belongs to the aspartokinase family.


ensembl_gene_id: ANME2D_00055
symbol: pan
gene_biotype: protein_coding
description:
  26S proteasome subunit P45 family; PFAM: ATPase family associated with various cellular activities (AAA); TIGRFAM: 26S proteasome subunit P45 family; Belongs to the AAA ATPase family.


ensembl_gene_id: ANME2D_00057
symbol: KCZ72998.1
gene_biotype: protein_coding
description:
  ABC-type transport system, involved in lipoprotein release, permease component; PFAM: MacB-like periplasmic core domain; FtsX-like permease family.


ensembl_gene_id: ANME2D_00062
symbol: purB
gene_biotype: protein_coding
description:
  PFAM: Lyase; Adenylosuccinate lyase C-terminus; TIGRFAM: adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.


ensembl_gene_id: ANME2D_00071
symbol: KCZ73012.1
gene_biotype: protein_coding
description:
  Dehydrogenase of unknown specificity, short-chain alcohol dehydrogenase like; PFAM: short chain dehydrogenase.


ensembl_gene_id: ANME2D_00072
symbol: tdh
gene_biotype: protein_coding
description:
  Theronine dehydrogenase-like Zn-dependent dehydrogenase; PFAM: Alcohol dehydrogenase GroES-like domain; Zinc-binding dehydrogenase; TIGRFAM: L-threonine 3-dehydrogenase.


ensembl_gene_id: ANME2D_00075
symbol: KCZ73016.1
gene_biotype: protein_coding
description:
  Putative heme/steroid binding protein; PFAM: Response regulator receiver domain; Cytochrome b5-like Heme/Steroid binding domain.


ensembl_gene_id: ANME2D_00077
symbol: gpmI
gene_biotype: protein_coding
description:
  Phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the BPG-independent phosphoglycerate mutase family.


ensembl_gene_id: ANME2D_00080
symbol: aspS
gene_biotype: protein_coding
description:
  aspartyl-tRNA synthetase, archaeal type; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).


ensembl_gene_id: ANME2D_00082
symbol: smc
gene_biotype: protein_coding
description:
  Chromosome segregation protein SMC; Required for chromosome condensation and partitioning. Belongs to the SMC family.


ensembl_gene_id: ANME2D_00083
symbol: thiI
gene_biotype: protein_coding
description:
  Thiazole biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.


ensembl_gene_id: ANME2D_00110
symbol: KCZ73051.1
gene_biotype: protein_coding
description:
  Zn-dependent oxidoreductase, NADPH:quinone reductase; PFAM: Alcohol dehydrogenase GroES-like domain; Zinc-binding dehydrogenase.


ensembl_gene_id: ANME2D_00111
symbol: KCZ73052.1
gene_biotype: protein_coding
description:
  Ferredoxin subunit of nitrite reductase and ring-hydroxylating dioxygenase; PFAM: Rieske [2Fe-2S] domain.


ensembl_gene_id: ANME2D_00112
symbol: KCZ73053.1
gene_biotype: protein_coding
description:
  Ferredoxin-thioredoxin reductase, catalytic subunit; PFAM: Ferredoxin thioredoxin reductase catalytic beta chain.


ensembl_gene_id: ANME2D_00117
symbol: KCZ73058.1
gene_biotype: protein_coding
description:
  Copper/silver-translocating P-type ATPase; PFAM: E1-E2 ATPase; haloacid dehalogenase-like hydrolase; TIGRFAM: copper-(or silver)-translocating P-type ATPase; heavy metal translocating P-type ATPase; ATPase, P-type (transporting), HAD superfamily, subfamily IC.


ensembl_gene_id: ANME2D_00119
symbol: KCZ73060.1
gene_biotype: protein_coding
description:
  N-terminal double-transmembrane domain-containing protein; PFAM: von Willebrand factor type A domain; Aerotolerance regulator N-terminal; TIGRFAM: N-terminal double-transmembrane domain.


ensembl_gene_id: ANME2D_00126
symbol: KCZ73067.1
gene_biotype: protein_coding
description:
  PFAM: Hydrogenase maturation protease; TIGRFAM: hydrogenase expression/formation protein; hydrogenase maturation protease.


ensembl_gene_id: ANME2D_00128
symbol: KCZ73069.1
gene_biotype: protein_coding
description:
  Coenzyme F420-reducing hydrogenase, gamma subunit; PFAM: NADH ubiquinone oxidoreductase, 20 Kd subunit.


ensembl_gene_id: ANME2D_00129
symbol: KCZ73070.1
gene_biotype: protein_coding
description:
  2-polyprenylphenol hydroxylase-like oxidoreductase; PFAM: Oxidoreductase FAD-binding domain; Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B; Oxidoreductase NAD-binding domain.


ensembl_gene_id: ANME2D_00137
symbol: cca
gene_biotype: protein_coding
description:
  CCA-adding enzyme; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.


ensembl_gene_id: ANME2D_00143
symbol: KCZ73084.1
gene_biotype: protein_coding
description:
  Putative RND superfamily exporter; PFAM: MMPL family; TIGRFAM: The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family.


ensembl_gene_id: ANME2D_00152
symbol: purM
gene_biotype: protein_coding
description:
  Phosphoribosylformylglycinamidine cyclo-ligase; PFAM: AIR synthase related protein, N-terminal domain; AIR synthase related protein, C-terminal domain; TIGRFAM: phosphoribosylaminoimidazole synthetase.


ensembl_gene_id: ANME2D_00156
symbol: KCZ73097.1
gene_biotype: protein_coding
description:
  Molybdenum-pterin binding domain; PFAM: TOBE domain; Bacterial regulatory helix-turn-helix protein, lysR family; TIGRFAM: molybdenum-pterin binding domain; ModE molybdate transport repressor domain.


ensembl_gene_id: ANME2D_00158
symbol: KCZ73099.1
gene_biotype: protein_coding
description:
  ABC-type tungstate transport system, periplasmic component; PFAM: Binding-protein-dependent transport system inner membrane component.


ensembl_gene_id: ANME2D_00161
symbol: KCZ73102.1
gene_biotype: protein_coding
description:
  (NiFe) hydrogenase maturation protein HypF; PFAM: HypF finger; Glycoprotease family; Acylphosphatase; Telomere recombination; TIGRFAM: [NiFe] hydrogenase maturation protein HypF.


ensembl_gene_id: ANME2D_00162
symbol: KCZ73103.1
gene_biotype: protein_coding
description:
  Hydrogenase expression/formation protein HypE; PFAM: AIR synthase related protein, N-terminal domain; AIR synthase related protein, C-terminal domain; TIGRFAM: hydrogenase expression/formation protein HypE.


ensembl_gene_id: ANME2D_00170
symbol: KCZ73111.1
gene_biotype: protein_coding
description:
  Cobalt transport protein ATP-binding subunit; Part of an ABC transporter complex. Responsible for energy coupling to the transport system.


ensembl_gene_id: ANME2D_00172
symbol: KCZ73113.1
gene_biotype: protein_coding
description:
  ABC-type Co2+ transport system, permease component; PFAM: Cobalt uptake substrate-specific transmembrane region; TIGRFAM: cobalamin biosynthesis protein CbiM.


ensembl_gene_id: ANME2D_00173
symbol: KCZ73114.1
gene_biotype: protein_coding
description:
  Putative membrane protein; PFAM: Domain of unknown function (DUF389); TIGRFAM: uncharacterized hydrophobic domain.


ensembl_gene_id: ANME2D_00179
symbol: glyS
gene_biotype: protein_coding
description:
  glycyl-tRNA synthetase; PFAM: Anticodon binding domain; tRNA synthetase class II core domain (G, H, P, S and T); TIGRFAM: glycyl-tRNA synthetase, dimeric type.


ensembl_gene_id: ANME2D_00183
symbol: KCZ73124.1
gene_biotype: protein_coding
description:
  Putative Fe-S oxidoreductase; PFAM: Radical SAM superfamily; TIGRFAM: nitrogenase cofactor biosynthesis protein NifB.


ensembl_gene_id: ANME2D_00188
symbol: KCZ73129.1
gene_biotype: protein_coding
description:
  CRISPR-associated protein Cas4; PFAM: Domain of unknown function DUF83; TIGRFAM: CRISPR-associated protein Cas4.


ensembl_gene_id: ANME2D_00189
symbol: cas
gene_biotype: protein_coding
description:
  CRISPR-associated endoribonuclease Cas2; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.


ensembl_gene_id: ANME2D_00190
symbol: cas-2
gene_biotype: protein_coding
description:
  CRISPR-associated endonuclease Cas1; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.


ensembl_gene_id: ANME2D_00195
symbol: KCZ73136.1
gene_biotype: protein_coding
description:
  PFAM: DEAD/DEAH box helicase; TIGRFAM: CRISPR-associated helicase Cas3; CRISPR-associated endonuclease Cas3-HD.


ensembl_gene_id: ANME2D_00196
symbol: KCZ73137.1
gene_biotype: protein_coding
description:
  PFAM: CRISPR-associated protein (Cas_Cas5); TIGRFAM: CRISPR-associated protein Cas5, subtype I-B/HMARI; CRISPR-associated protein Cas5, N-terminal domain.


ensembl_gene_id: ANME2D_00197
symbol: KCZ73138.1
gene_biotype: protein_coding
description:
  CRISPR-associated protein Cas7/Cst2/DevR, subtype I-B/TNEAP; PFAM: CRISPR-associated negative auto-regulator DevR/Csa2; TIGRFAM: CRISPR-associated autoregulator DevR family; CRISPR-associated protein Cas7/Cst2/DevR, subtype I-B/TNEAP.


ensembl_gene_id: ANME2D_00203
symbol: gcvH
gene_biotype: protein_coding
description:
  Glycine cleavage system H protein (lipoate-binding); The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.


ensembl_gene_id: ANME2D_00204
symbol: surE
gene_biotype: protein_coding
description:
  5'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.


ensembl_gene_id: ANME2D_00211
symbol: pcn
gene_biotype: protein_coding
description:
  DNA polymerase sliding clamp subunit; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.


ensembl_gene_id: ANME2D_00213
symbol: rio
gene_biotype: protein_coding
description:
  RIO-like serine/threonine protein kinase fused to N-terminal HTH domain; PFAM: RIO1 family; Rio2, N-terminal.


ensembl_gene_id: ANME2D_00217
symbol: KCZ73158.1
gene_biotype: protein_coding
description:
  PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; GAF domain; His Kinase A (phospho-acceptor) domain; Phosphoserine phosphatase RsbU, N-terminal domain.


ensembl_gene_id: ANME2D_00223
symbol: KCZ73164.1
gene_biotype: protein_coding
description:
  ABC-type metal ion transport system, periplasmic component/surface adhesin; PFAM: Periplasmic solute binding protein family.


ensembl_gene_id: ANME2D_00224
symbol: KCZ73165.1
gene_biotype: protein_coding
description:
  Mn-dependent transcriptional regulator; PFAM: Iron dependent repressor, metal binding and dimerisation domain; Iron dependent repressor, N-terminal DNA binding domain.


ensembl_gene_id: ANME2D_00233
symbol: cofC
gene_biotype: protein_coding
description:
  Phospholactate guanylyltransferase; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor; Belongs to the CofC family.


ensembl_gene_id: ANME2D_00234
symbol: gyrA
gene_biotype: protein_coding
description:
  DNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.


ensembl_gene_id: ANME2D_00237
symbol: gyrB
gene_biotype: protein_coding
description:
  DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.


ensembl_gene_id: ANME2D_00238
symbol: glmU
gene_biotype: protein_coding
description:
  PFAM: Nucleotidyl transferase; Bacterial transferase hexapeptide (six repeats); TIGRFAM: UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; glucose-1-phosphate thymidylylransferase, long form.


ensembl_gene_id: ANME2D_00239
symbol: glmM
gene_biotype: protein_coding
description:
  PFAM: Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III; Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II; Phosphoglucomutase/phosphomannomutase, C-terminal domain; Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I; TIGRFAM: phosphoglucosamine mutase; Belongs to the phosphohexose mutase family.


ensembl_gene_id: ANME2D_00240
symbol: glmS
gene_biotype: protein_coding
description:
  Glucosamine--fructose-6-phosphate aminotransferase, isomerizing; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.


ensembl_gene_id: ANME2D_00244
symbol: thrC
gene_biotype: protein_coding
description:
  L-threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine.


ensembl_gene_id: ANME2D_00247
symbol: rnj
gene_biotype: protein_coding
description:
  Putative hydrolase of the metallo-beta-lactamase superfamily; An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation; Belongs to the metallo-beta-lactamase superfamily. RNA- metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.


ensembl_gene_id: ANME2D_00248
symbol: fni
gene_biotype: protein_coding
description:
  Isopentenyl-diphosphate delta-isomerase; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).


ensembl_gene_id: ANME2D_00250
symbol: mvk
gene_biotype: protein_coding
description:
  Mevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily.


ensembl_gene_id: ANME2D_00254
symbol: purP
gene_biotype: protein_coding
description:
  ATP-utilizing enzymes of ATP-grasp superfamily (probably carboligase); PFAM: Domain of unknown function (DUF1297); Protein of unknown function (DUF1246).


ensembl_gene_id: ANME2D_00256
symbol: KCZ73196.1
gene_biotype: protein_coding
description:
  Membrane-bound serine protease (ClpP class); PFAM: NfeD-like C-terminal, partner-binding; Clp protease.


ensembl_gene_id: ANME2D_00260
symbol: cheB
gene_biotype: protein_coding
description:
  Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain; PFAM: CheB methylesterase.


ensembl_gene_id: ANME2D_00262
symbol: KCZ73202.1
gene_biotype: protein_coding
description:
  PAS domain S-box; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phospho-acceptor) domain; PAS domain; TIGRFAM: PAS domain S-box.


ensembl_gene_id: ANME2D_00268
symbol: KCZ73208.1
gene_biotype: protein_coding
description:
  PFAM: Phosphatidylethanolamine-binding protein; TIGRFAM: Raf kinase inhibitor-like protein, YbhB/YbcL family.


ensembl_gene_id: ANME2D_00269
symbol: KCZ73209.1
gene_biotype: protein_coding
description:
  2-oxoacid:ferredoxin oxidoreductase, gamma subunit; PFAM: Pyruvate ferredoxin/flavodoxin oxidoreductase.


ensembl_gene_id: ANME2D_00270
symbol: KCZ73210.1
gene_biotype: protein_coding
description:
  2-oxoacid:ferredoxin oxidoreductase, beta subunit; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP binding domain.


ensembl_gene_id: ANME2D_00271
symbol: KCZ73211.1
gene_biotype: protein_coding
description:
  2-oxoacid:ferredoxin oxidoreductase, alpha subunit; PFAM: Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg; Transketolase, C-terminal domain.


ensembl_gene_id: ANME2D_00277
symbol: KCZ73217.1
gene_biotype: protein_coding
description:
  CRISPR-associated protein Cas7/Cst2/DevR, subtype I-B/TNEAP; PFAM: CRISPR-associated negative auto-regulator DevR/Csa2; TIGRFAM: CRISPR-associated autoregulator DevR family; CRISPR-associated protein Cas7/Csp1, subtype PGING; CRISPR-associated protein Cas7/Cst2/DevR, subtype I-B/TNEAP.


ensembl_gene_id: ANME2D_00280
symbol: KCZ73220.1
gene_biotype: protein_coding
description:
  PFAM: HD domain; DEAD/DEAH box helicase; TIGRFAM: CRISPR-associated helicase Cas3; CRISPR-associated endonuclease Cas3-HD.


ensembl_gene_id: ANME2D_00281
symbol: KCZ73221.1
gene_biotype: protein_coding
description:
  Mn-dependent transcriptional regulator; PFAM: Bacterial regulatory protein, arsR family; Nucleotidyltransferase domain.


ensembl_gene_id: ANME2D_00283
symbol: hel308
gene_biotype: protein_coding
description:
  Superfamily II helicase; DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.


ensembl_gene_id: ANME2D_00284
symbol: uppS
gene_biotype: protein_coding
description:
  Undecaprenyl diphosphate synthase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.


ensembl_gene_id: ANME2D_00288
symbol: KCZ73228.1
gene_biotype: protein_coding
description:
  P-type ATPase, translocating; PFAM: E1-E2 ATPase; Cation transporting ATPase, C-terminus; haloacid dehalogenase-like hydrolase; Cation transporter/ATPase, N-terminus; TIGRFAM: plasma-membrane calcium-translocating P-type ATPase; ATPase, P-type (transporting), HAD superfamily, subfamily IC; potassium and/or sodium efflux P-type ATPase, fungal-type.


ensembl_gene_id: ANME2D_00295
symbol: arsB
gene_biotype: protein_coding
description:
  Arsenical-resistance protein; PFAM: Sodium Bile acid symporter family; TIGRFAM: arsenical-resistance protein.


ensembl_gene_id: ANME2D_00298
symbol: KCZ73235.1
gene_biotype: protein_coding
description:
  4-hydroxybenzoate polyprenyltransferase-like prenyltransferase; PFAM: UbiA prenyltransferase family.


ensembl_gene_id: ANME2D_00299
symbol: fusA
gene_biotype: protein_coding
description:
  Translation elongation factor aEF-2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF [...]


ensembl_gene_id: ANME2D_00306
symbol: KCZ73243.1
gene_biotype: protein_coding
description:
  Putative non-F420 flavinoid oxidoreductase; PFAM: Luciferase-like monooxygenase; TIGRFAM: F420-dependent oxidoreductase, G6PDH family; probable non-F420 flavinoid oxidoreductase.


ensembl_gene_id: ANME2D_00307
symbol: msrA
gene_biotype: protein_coding
description:
  methionine-S-sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.


ensembl_gene_id: ANME2D_00312
symbol: rnz
gene_biotype: protein_coding
description:
  Ribonuclease Z; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA; Belongs to the RNase Z family.


ensembl_gene_id: ANME2D_00317
symbol: KCZ73254.1
gene_biotype: protein_coding
description:
  Glycosyl transferase, UDP-glucuronosyltransferase; PFAM: Glycosyl transferase family 1; TIGRFAM: conserved hypothetical protein.


ensembl_gene_id: ANME2D_00319
symbol: KCZ73256.1
gene_biotype: protein_coding
description:
  tRNA(Ile2) 2-agmatinylcytidine synthetase; PFAM: Domain of unknown function (DUF1743); TIGRFAM: methanogenesis imperfect marker protein 11.


ensembl_gene_id: ANME2D_00320
symbol: KCZ73257.1
gene_biotype: protein_coding
description:
  Indolepyruvate ferredoxin oxidreductase, alpha/beta subunit; PFAM: Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain.


ensembl_gene_id: ANME2D_00327
symbol: ribC
gene_biotype: protein_coding
description:
  Riboflavin synthase alpha chain; PFAM: 6,7-dimethyl-8-ribityllumazine synthase; TIGRFAM: riboflavin synthase.


ensembl_gene_id: ANME2D_00329
symbol: KCZ73264.1
gene_biotype: protein_coding
description:
  PFAM: Helicase conserved C-terminal domain; ERCC4 domain; Helix-hairpin-helix motif; DEAD/DEAH box helicase.


ensembl_gene_id: ANME2D_00330
symbol: KCZ73265.1
gene_biotype: protein_coding
description:
  Prefoldin alpha subunit; PFAM: PUA domain; Patch-forming domain C2 of tRNA-guanine transglycosylase; TIGRFAM: uncharacterized domain 2.


ensembl_gene_id: ANME2D_00331
symbol: KCZ73266.1
gene_biotype: protein_coding
description:
  Retron-type reverse transcriptase; PFAM: Group II intron, maturase-specific domain; Reverse transcriptase (RNA-dependent DNA polymerase).


ensembl_gene_id: ANME2D_00333
symbol: nnr
gene_biotype: protein_coding
description:
  yjeF-like protein, hydroxyethylthiazole kinase-related; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.  Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydrata [...]


ensembl_gene_id: ANME2D_00335
symbol: moaC
gene_biotype: protein_coding
description:
  Cyclic pyranopterin monophosphate synthase subunit MoaC; PFAM: MoaC family; TIGRFAM: molybdenum cofactor biosynthesis protein MoaC.


ensembl_gene_id: ANME2D_00336
symbol: gatD
gene_biotype: protein_coding
description:
  glutamyl-tRNA(Gln) amidotransferase, subunit D; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.


ensembl_gene_id: ANME2D_00341
symbol: albA
gene_biotype: protein_coding
description:
  Nucleoid protein Alba; Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes; Belongs to the histone-like Alba family.


ensembl_gene_id: ANME2D_00347
symbol: aroE
gene_biotype: protein_coding
description:
  Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).


ensembl_gene_id: ANME2D_00351
symbol: secY
gene_biotype: protein_coding
description:
  Protein translocase subunit secY/sec61 alpha; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.


ensembl_gene_id: ANME2D_00352
symbol: rpl15p
gene_biotype: protein_coding
description:
  Ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family.


ensembl_gene_id: ANME2D_00355
symbol: rpl18p
gene_biotype: protein_coding
description:
  Ribosomal protein L18; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.


ensembl_gene_id: ANME2D_00356
symbol: rpl19e
gene_biotype: protein_coding
description:
  Ribosomal protein L19E; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL19 family.


ensembl_gene_id: ANME2D_00358
symbol: rpl
gene_biotype: protein_coding
description:
  Archaeal ribosomal protein L6P; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family.


ensembl_gene_id: ANME2D_00359
symbol: rps-2
gene_biotype: protein_coding
description:
  Ribosomal protein S8; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family.


ensembl_gene_id: ANME2D_00361
symbol: rpl-2
gene_biotype: protein_coding
description:
  Ribosomal protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.


ensembl_gene_id: ANME2D_00362
symbol: rps4e
gene_biotype: protein_coding
description:
  PFAM: S4 domain; Ribosomal family S4e; RS4NT (NUC023) domain; Belongs to the eukaryotic ribosomal protein eS4 family.


ensembl_gene_id: ANME2D_00364
symbol: rplN
gene_biotype: protein_coding
description:
  LSU ribosomal protein L14P; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family.


ensembl_gene_id: ANME2D_00365
symbol: rps17p
gene_biotype: protein_coding
description:
  Archaeal ribosomal protein S17P; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.


ensembl_gene_id: ANME2D_00366
symbol: rnp
gene_biotype: protein_coding
description:
  RNase P/RNase MRP subunit p29; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends; Belongs to the eukaryotic/archaeal RNase P protein component 1 family.


ensembl_gene_id: ANME2D_00367
symbol: rpl29p
gene_biotype: protein_coding
description:
  PFAM: Ribosomal L29 protein; TIGRFAM: ribosomal protein L29; Belongs to the universal ribosomal protein uL29 family.


ensembl_gene_id: ANME2D_00368
symbol: rps-3
gene_biotype: protein_coding
description:
  Ribosomal protein S3, eukaryotic/archaeal type; Binds the lower part of the 30S subunit head. Belongs to the universal ribosomal protein uS3 family.


ensembl_gene_id: ANME2D_00369
symbol: rpl22p
gene_biotype: protein_coding
description:
  Ribosomal protein L22/L17; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.


ensembl_gene_id: ANME2D_00370
symbol: rps-4
gene_biotype: protein_coding
description:
  Ribosomal protein S19/S15; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.


ensembl_gene_id: ANME2D_00371
symbol: rpl-3
gene_biotype: protein_coding
description:
  Ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family.


ensembl_gene_id: ANME2D_00372
symbol: rpl23p
gene_biotype: protein_coding
description:
  Archaeal ribosomal protein L23; Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Belongs to the universal ribosomal protein uL23 family.


ensembl_gene_id: ANME2D_00374
symbol: rpl-5
gene_biotype: protein_coding
description:
  LSU ribosomal protein L3P; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family.


ensembl_gene_id: ANME2D_00386
symbol: KCZ73320.1
gene_biotype: protein_coding
description:
  DNA/RNA helicase, superfamily II; PFAM: Helicase conserved C-terminal domain; DEAD/DEAH box helicase; Belongs to the DEAD box helicase family.


ensembl_gene_id: ANME2D_00388
symbol: lig
gene_biotype: protein_coding
description:
  ATP-dependent DNA ligase I; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.


ensembl_gene_id: ANME2D_00389
symbol: pyrI
gene_biotype: protein_coding
description:
  Aspartate carbamoyltransferase, regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase.


ensembl_gene_id: ANME2D_00390
symbol: pyrB
gene_biotype: protein_coding
description:
  PFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; TIGRFAM: aspartate carbamoyltransferase.


ensembl_gene_id: ANME2D_00395
symbol: KCZ73329.1
gene_biotype: protein_coding
description:
  Anaerobic dehydrogenase, typically selenocysteine-containing; PFAM: TAT (twin-arginine translocation) pathway signal sequence; Molybdopterin oxidoreductase; Molydopterin dinucleotide binding domain; Molybdopterin oxidoreductase Fe4S4 domain.


ensembl_gene_id: ANME2D_00396
symbol: KCZ73330.1
gene_biotype: protein_coding
description:
  Response regulator; PFAM: Helix-turn-helix domain; Response regulator receiver domain; response regulator with CheY-like receiver, AAA-type ATPase, and DNA-binding domains.


ensembl_gene_id: ANME2D_00397
symbol: KCZ73331.1
gene_biotype: protein_coding
description:
  PAS domain S-box; PFAM: HAMP domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phospho-acceptor) domain; PAS fold; TIGRFAM: PAS domain S-box.


ensembl_gene_id: ANME2D_00398
symbol: KCZ73332.1
gene_biotype: protein_coding
description:
  PFAM: ABC transporter, phosphonate, periplasmic substrate-binding protein; TIGRFAM: phosphate/phosphite/phosphonate ABC transporters, periplasmic binding protein.


ensembl_gene_id: ANME2D_00400
symbol: KCZ73334.1
gene_biotype: protein_coding
description:
  Histidine kinase,HAMP domain-containing protein,histidine kinase; PFAM: HAMP domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phospho-acceptor) domain.


ensembl_gene_id: ANME2D_00405
symbol: KCZ73339.1
gene_biotype: protein_coding
description:
  Anaerobic dehydrogenase, typically selenocysteine-containing; PFAM: Molybdopterin oxidoreductase; Molydopterin dinucleotide binding domain; Molybdopterin oxidoreductase Fe4S4 domain.


ensembl_gene_id: ANME2D_00406
symbol: moaA
gene_biotype: protein_coding
description:
  Cyclic pyranopterin monophosphate synthase subunit MoaA; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate; Belongs to the radical SAM superfamily. MoaA family.


ensembl_gene_id: ANME2D_00407
symbol: KCZ73341.1
gene_biotype: protein_coding
description:
  Molybdenum cofactor synthesis domain; PFAM: Probable molybdopterin binding domain; MoeA N-terminal region (domain I and II); TIGRFAM: molybdenum cofactor synthesis domain.


ensembl_gene_id: ANME2D_00409
symbol: KCZ73343.1
gene_biotype: protein_coding
description:
  PFAM: DNA / pantothenate metabolism flavoprotein; Flavoprotein; TIGRFAM: phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase.


ensembl_gene_id: ANME2D_00413
symbol: KCZ73347.1
gene_biotype: protein_coding
description:
  Putative GTPase or GTP-binding protein; PFAM: Molybdopterin guanine dinucleotide synthesis protein B.


ensembl_gene_id: ANME2D_00417
symbol: KCZ73351.1
gene_biotype: protein_coding
description:
  PFAM: Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; 4Fe-4S dicluster domain; Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus.


ensembl_gene_id: ANME2D_00419
symbol: KCZ73353.1
gene_biotype: protein_coding
description:
  PFAM: Aldehyde ferredoxin oxidoreductase, N-terminal domain; Aldehyde ferredoxin oxidoreductase, domains 2 & 3.


ensembl_gene_id: ANME2D_00425
symbol: mptD
gene_biotype: protein_coding
description:
  Hypothetical protein; Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD); Belongs to the archaeal dihydroneopterin aldolase family.


ensembl_gene_id: ANME2D_00426
symbol: KCZ73360.1
gene_biotype: protein_coding
description:
  Archaetidylserine synthase; PFAM: CDP-alcohol phosphatidyltransferase; TIGRFAM: CDP-diacylglycerol--serine O-phosphatidyltransferase; archaetidylserine synthase.


ensembl_gene_id: ANME2D_00427
symbol: psd
gene_biotype: protein_coding
description:
  Phosphatidylserine decarboxylase precursor-related protein; Catalyzes the formation of archaetidylethanolamine (PtdEtn) from archaetidylserine (PtdSer); Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.


ensembl_gene_id: ANME2D_00428
symbol: KCZ73362.1
gene_biotype: protein_coding
description:
  Archaeosortase A, PGF-CTERM-specific; PFAM: Transmembrane exosortase (Exosortase_EpsH); TIGRFAM: exosortase/archaeosortase family protein; archaeosortase A, PGF-CTERM-specific.


ensembl_gene_id: ANME2D_00432
symbol: speA
gene_biotype: protein_coding
description:
  PFAM: Pyridoxal-dependent decarboxylase, C-terminal sheet domain; Pyridoxal-dependent decarboxylase, pyridoxal binding domain; TIGRFAM: arginine decarboxylase, biosynthetic.


ensembl_gene_id: ANME2D_00436
symbol: KCZ73370.1
gene_biotype: protein_coding
description:
  Parallel beta-helix repeat (two copies); PFAM: Periplasmic copper-binding protein (NosD); TIGRFAM: parallel beta-helix repeat (two copies).


ensembl_gene_id: ANME2D_00437
symbol: KCZ73371.1
gene_biotype: protein_coding
description:
  PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit.


ensembl_gene_id: ANME2D_00438
symbol: cbiD
gene_biotype: protein_coding
description:
  Cobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.


ensembl_gene_id: ANME2D_00439
symbol: mutL
gene_biotype: protein_coding
description:
  DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.


ensembl_gene_id: ANME2D_00440
symbol: KCZ73374.1
gene_biotype: protein_coding
description:
  PFAM: Uncharacterized conserved protein (DUF2276); TIGRFAM: CRISPR-associated endoribonuclease Cas6.


ensembl_gene_id: ANME2D_00451
symbol: KCZ73385.1
gene_biotype: protein_coding
description:
  Uncharacterized protein predicted to be involved in DNA repair; PFAM: CRISPR associated protein Cas1.


ensembl_gene_id: ANME2D_00457
symbol: KCZ73391.1
gene_biotype: protein_coding
description:
  Zinc metalloprotease (elastase); PFAM: Thermolysin metallopeptidase, alpha-helical domain; Thermolysin metallopeptidase, catalytic domain.


ensembl_gene_id: ANME2D_00461
symbol: carA
gene_biotype: protein_coding
description:
  PFAM: Carbamoyl-phosphate synthase small chain, CPSase domain; Glutamine amidotransferase class-I; TIGRFAM: carbamoyl-phosphate synthase, small subunit; Belongs to the CarA family.


ensembl_gene_id: ANME2D_00462
symbol: KCZ73396.1
gene_biotype: protein_coding
description:
  Mn-dependent transcriptional regulator; PFAM: FeoA domain; Iron dependent repressor, metal binding and dimerisation domain; Iron dependent repressor, N-terminal DNA binding domain.


ensembl_gene_id: ANME2D_00468
symbol: hppA
gene_biotype: protein_coding
description:
  Vacuolar-type H(+)-translocating pyrophosphatase; Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force.


ensembl_gene_id: ANME2D_00472
symbol: KCZ73406.1
gene_biotype: protein_coding
description:
  ABC-type multidrug transport system, ATPase and permease component; PFAM: ABC transporter; ABC transporter transmembrane region.


ensembl_gene_id: ANME2D_00476
symbol: hypA
gene_biotype: protein_coding
description:
  Hydrogenase nickel insertion protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.


ensembl_gene_id: ANME2D_00480
symbol: KCZ73414.1
gene_biotype: protein_coding
description:
  Mg2+ transporter MgtE; PFAM: MgtE intracellular N domain; Divalent cation transporter; CBS domain; TIGRFAM: Mg2+ transporter (mgtE).


ensembl_gene_id: ANME2D_00484
symbol: KCZ73418.1
gene_biotype: protein_coding
description:
  Putative sugar nucleotidyltransferase; PFAM: MobA-like NTP transferase domain; CDP-alcohol phosphatidyltransferase.


ensembl_gene_id: ANME2D_00488
symbol: mtrE
gene_biotype: protein_coding
description:
  Tetrahydromethanopterin S-methyltransferase, subunit E; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.


ensembl_gene_id: ANME2D_00489
symbol: mtrD
gene_biotype: protein_coding
description:
  Tetrahydromethanopterin S-methyltransferase, subunit D; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.


ensembl_gene_id: ANME2D_00490
symbol: KCZ73424.1
gene_biotype: protein_coding
description:
  PFAM: Tetrahydromethanopterin S-methyltransferase, subunit C; TIGRFAM: N5-methyltetrahydromethanopterin:coenzyme M methyltransferase subunit C.


ensembl_gene_id: ANME2D_00491
symbol: mtrB
gene_biotype: protein_coding
description:
  Tetrahydromethanopterin S-methyltransferase, subunit B; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.


ensembl_gene_id: ANME2D_00492
symbol: mtrA
gene_biotype: protein_coding
description:
  Tetrahydromethanopterin S-methyltransferase, subunit A; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step; Belongs to the MtrA family.


ensembl_gene_id: ANME2D_00493
symbol: mtrF
gene_biotype: protein_coding
description:
  PFAM: Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF); TIGRFAM: tetrahydromethanopterin S-methyltransferase, F subunit.


ensembl_gene_id: ANME2D_00494
symbol: mtrG
gene_biotype: protein_coding
description:
  Tetrahydromethanopterin S-methyltransferase, subunit G; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.


ensembl_gene_id: ANME2D_00495
symbol: mtrH
gene_biotype: protein_coding
description:
  PFAM: Tetrahydromethanopterin S-methyltransferase MtrH subunit; TIGRFAM: N5-methyltetrahydromethanopterin:coenzyme M methyltransferase subunit H.


ensembl_gene_id: ANME2D_00518
symbol: KCZ73450.1
gene_biotype: protein_coding
description:
  Nucleoside 2-deoxyribosyltransferase; Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base; Belongs to the 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 family.


ensembl_gene_id: ANME2D_00519
symbol: ftsZ
gene_biotype: protein_coding
description:
  Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.


ensembl_gene_id: ANME2D_00520
symbol: cdhE
gene_biotype: protein_coding
description:
  CO dehydrogenase/acetyl-CoA synthase gamma subunit (corrinoid Fe-S protein); Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2).


ensembl_gene_id: ANME2D_00521
symbol: cdhD
gene_biotype: protein_coding
description:
  acetyl-CoA decarbonylase/synthase delta subunit; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). Probably maintains the overall quaternary structure of the ACDS complex. Belongs to the CdhD family.


ensembl_gene_id: ANME2D_00529
symbol: KCZ73461.1
gene_biotype: protein_coding
description:
  TIGR00251 family protein; PFAM: Uncharacterised ACR, YggU family COG1872; TIGRFAM: TIGR00251 family protein.


ensembl_gene_id: ANME2D_00532
symbol: KCZ73464.1
gene_biotype: protein_coding
description:
  Putative Rossmann fold nucleotide-binding protein involved in DNA uptake; PFAM: DNA recombination-mediator protein A; TIGRFAM: DNA protecting protein DprA.


ensembl_gene_id: ANME2D_00551
symbol: KCZ73483.1
gene_biotype: protein_coding
description:
  Site-specific recombinase XerD; PFAM: Phage integrase, N-terminal SAM-like domain; Phage integrase family.


ensembl_gene_id: ANME2D_00554
symbol: purP-2
gene_biotype: protein_coding
description:
  ATP-utilizing enzymes of ATP-grasp superfamily (probably carboligase); Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.


ensembl_gene_id: ANME2D_00559
symbol: pelA
gene_biotype: protein_coding
description:
  Cell division protein pelota; May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.


ensembl_gene_id: ANME2D_00562
symbol: cas-3
gene_biotype: protein_coding
description:
  CRISPR-associated protein, Cas2 family; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.


ensembl_gene_id: ANME2D_00563
symbol: cas1
gene_biotype: protein_coding
description:
  CRISPR-associated protein, Cas1 family; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.


ensembl_gene_id: ANME2D_00564
symbol: cas-4
gene_biotype: protein_coding
description:
  CRISPR-associated exonuclease, Cas4 family; CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Belongs to the CRISPR-associated exonuclease Cas4 family.


ensembl_gene_id: ANME2D_00566
symbol: KCZ73498.1
gene_biotype: protein_coding
description:
  Putative nucleic acid-binding protein, contains PIN domain; PFAM: Domain of unknown function (DUF3368).


ensembl_gene_id: ANME2D_00581
symbol: KCZ73513.1
gene_biotype: protein_coding
description:
  ATP-dependent chaperone ClpB; PFAM: AAA domain (Cdc48 subfamily); C-terminal, D2-small domain, of ClpB protein; Clp amino terminal domain; ATPase family associated with various cellular activities (AAA); TIGRFAM: ATP-dependent chaperone ClpB.


ensembl_gene_id: ANME2D_00582
symbol: KCZ73514.1
gene_biotype: protein_coding
description:
  PFAM: Domain of unknown function (DUF3387); Type I restriction enzyme R protein N terminus (HSDR_N); Type III restriction enzyme, res subunit; TIGRFAM: type I site-specific deoxyribonuclease, HsdR family.


ensembl_gene_id: ANME2D_00585
symbol: KCZ73517.1
gene_biotype: protein_coding
description:
  Putative transcriptional regulator with HTH domain; PFAM: HTH domain; Divergent AAA domain; ATP-dependent DNA helicase recG C-terminal.


ensembl_gene_id: ANME2D_00586
symbol: KCZ73518.1
gene_biotype: protein_coding
description:
  PFAM: N-6 DNA Methylase; HsdM N-terminal domain; TIGRFAM: type I restriction system adenine methylase (hsdM).


ensembl_gene_id: ANME2D_00591
symbol: thiC
gene_biotype: protein_coding
description:
  Hydroxymethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.


ensembl_gene_id: ANME2D_00594
symbol: ruvB
gene_biotype: protein_coding
description:
  PFAM: Holliday junction DNA helicase ruvB C-terminus; Holliday junction DNA helicase ruvB N-terminus; TIGRFAM: Holliday junction DNA helicase, RuvB subunit.


ensembl_gene_id: ANME2D_00595
symbol: ruvA
gene_biotype: protein_coding
description:
  Holliday junction DNA helicase subunit RuvA; PFAM: RuvA, C-terminal domain; RuvA N terminal domain; Helix-hairpin-helix domain; TIGRFAM: Holliday junction DNA helicase, RuvA subunit.


ensembl_gene_id: ANME2D_00596
symbol: ruvC
gene_biotype: protein_coding
description:
  PFAM: Crossover junction endodeoxyribonuclease RuvC; TIGRFAM: crossover junction endodeoxyribonuclease RuvC.


ensembl_gene_id: ANME2D_00597
symbol: ppnK
gene_biotype: protein_coding
description:
  Putative sugar kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.


ensembl_gene_id: ANME2D_00604
symbol: KCZ73534.1
gene_biotype: protein_coding
description:
  DnaJ-class molecular chaperone with C-terminal Zn finger domain; PFAM: NapC/NirT cytochrome c family, N-terminal region; Cytochrome c3.


ensembl_gene_id: ANME2D_00606
symbol: kptA
gene_biotype: protein_coding
description:
  RNA:NAD 2'-phosphotransferase; Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''- cyclic phosphate (APPR>P). May function as an ADP-ribosylase.


ensembl_gene_id: ANME2D_00608
symbol: thrB
gene_biotype: protein_coding
description:
  Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.


ensembl_gene_id: ANME2D_00614
symbol: KCZ73544.1
gene_biotype: protein_coding
description:
  Non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.


ensembl_gene_id: ANME2D_00615
symbol: KCZ73545.1
gene_biotype: protein_coding
description:
  Putative transcriptional regulator with CopG/Arc/MetJ DNA-binding domain and metal-binding domain; PFAM: Ribbon-helix-helix protein, copG family; NikR C terminal nickel binding domain; TIGRFAM: nickel-responsive transcriptional regulator NikR.


ensembl_gene_id: ANME2D_00627
symbol: prf
gene_biotype: protein_coding
description:
  Peptide chain release factor 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.


ensembl_gene_id: ANME2D_00634
symbol: KCZ73563.1
gene_biotype: protein_coding
description:
  Methylase involved in ubiquinone/menaquinone biosynthesis; PFAM: Methyltransferase domain; TIGRFAM: methionine biosynthesis protein MetW.


ensembl_gene_id: ANME2D_00639
symbol: ftr
gene_biotype: protein_coding
description:
  Formylmethanofuran-tetrahydromethanopterin formyltransferase; Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) so as to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR); Belongs to the FTR family.


ensembl_gene_id: ANME2D_00642
symbol: fabG
gene_biotype: protein_coding
description:
  Dehydrogenase of unknown specificity, short-chain alcohol dehydrogenase like; PFAM: short chain dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family.


ensembl_gene_id: ANME2D_00643
symbol: yqeF
gene_biotype: protein_coding
description:
  acetyl-CoA acetyltransferase; PFAM: Thiolase, C-terminal domain; Thiolase, N-terminal domain; TIGRFAM: acetyl-CoA acetyltransferases.


ensembl_gene_id: ANME2D_00644
symbol: fabG-2
gene_biotype: protein_coding
description:
  Dehydrogenase of unknown specificity, short-chain alcohol dehydrogenase like; PFAM: Enoyl-(Acyl carrier protein) reductase.


ensembl_gene_id: ANME2D_00645
symbol: phbC
gene_biotype: protein_coding
description:
  poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; PFAM: Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; alpha/beta hydrolase fold; TIGRFAM: poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit.


ensembl_gene_id: ANME2D_00658
symbol: KCZ73587.1
gene_biotype: protein_coding
description:
  Type I restriction-modification system methyltransferase subunit; PFAM: N-6 DNA Methylase; Type I restriction enzyme R protein N terminus (HSDR_N).


ensembl_gene_id: ANME2D_00671
symbol: thsA
gene_biotype: protein_coding
description:
  Thermosome subunit; PFAM: TCP-1/cpn60 chaperonin family; TIGRFAM: thermosome, various subunits, archaeal.


ensembl_gene_id: ANME2D_00672
symbol: grpE
gene_biotype: protein_coding
description:
  Molecular chaperone GrpE (heat shock protein); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle.  [...]


ensembl_gene_id: ANME2D_00674
symbol: dnaJ
gene_biotype: protein_coding
description:
  Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]


ensembl_gene_id: ANME2D_00676
symbol: KCZ73605.1
gene_biotype: protein_coding
description:
  Hypothetical protein; Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently.


ensembl_gene_id: ANME2D_00681
symbol: egsA
gene_biotype: protein_coding
description:
  Glycerol dehydrogenase-like oxidoreductase; Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1- phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea. Belongs to the glycerol-1-phosphate dehydrogenase family.


ensembl_gene_id: ANME2D_00683
symbol: hisD
gene_biotype: protein_coding
description:
  Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.


ensembl_gene_id: ANME2D_00695
symbol: polC
gene_biotype: protein_coding
description:
  DNA polymerase type II, large subunit; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase.


ensembl_gene_id: ANME2D_00698
symbol: cofH
gene_biotype: protein_coding
description:
  FO synthase subunit 2; Catalyzes the radical-mediated synthesis of 5-amino-5-(4- hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D- ribitylamino)uracil and L-tyrosine.


ensembl_gene_id: ANME2D_00699
symbol: cofG
gene_biotype: protein_coding
description:
  FO synthase subunit 1; Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D- ribitylimino)-5,6-dihydrouracil.


ensembl_gene_id: ANME2D_00720
symbol: KCZ73648.1
gene_biotype: protein_coding
description:
  Site-specific recombinase XerD; PFAM: Phage integrase, N-terminal SAM-like domain; zinc-ribbon domain; Phage integrase family.


ensembl_gene_id: ANME2D_00725
symbol: KCZ73653.1
gene_biotype: protein_coding
description:
  PFAM: RNA 3'-terminal phosphate cyclase (RTC), insert domain; RNA 3'-terminal phosphate cyclase; TIGRFAM: RNA 3'-phosphate cyclase.


ensembl_gene_id: ANME2D_00726
symbol: rpl-6
gene_biotype: protein_coding
description:
  LSU ribosomal protein L12AE; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the eukaryotic ribosomal protein P1/P2 family.


ensembl_gene_id: ANME2D_00731
symbol: argD
gene_biotype: protein_coding
description:
  PFAM: Aminotransferase class-III; TIGRFAM: transaminase, acetylornithine/succinylornithine family; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.


ensembl_gene_id: ANME2D_00738
symbol: KCZ73666.1
gene_biotype: protein_coding
description:
  PFAM: Uncharacterised protein family UPF0047; TIGRFAM: secondary thiamine-phosphate synthase enzyme.


ensembl_gene_id: ANME2D_00741
symbol: KCZ73668.1
gene_biotype: protein_coding
description:
  PAPS reductase/FAD synthetase family protein; PFAM: PUA domain; Phosphoadenosine phosphosulfate reductase family; TIGRFAM: uncharacterized domain 2.


ensembl_gene_id: ANME2D_00748
symbol: truD
gene_biotype: protein_coding
description:
  Hypothetical protein; Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs; Belongs to the pseudouridine synthase TruD family.


ensembl_gene_id: ANME2D_00749
symbol: purA
gene_biotype: protein_coding
description:
  Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.


ensembl_gene_id: ANME2D_00750
symbol: KCZ73677.1
gene_biotype: protein_coding
description:
  AAA family ATPase, CDC48 subfamily; PFAM: ATPase family associated with various cellular activities (AAA); Cell division protein 48 (CDC48), N-terminal domain; Cell division protein 48 (CDC48), domain 2; TIGRFAM: AAA family ATPase, CDC48 subfamily; Belongs to the AAA ATPase family.


ensembl_gene_id: ANME2D_00751
symbol: KCZ73678.1
gene_biotype: protein_coding
description:
  Pyruvate-formate lyase-activating enzyme; PFAM: Radical SAM superfamily; 4Fe-4S single cluster domain.


ensembl_gene_id: ANME2D_00754
symbol: KCZ73681.1
gene_biotype: protein_coding
description:
  Growth regulator; PFAM: Antidote-toxin recognition MazE; TIGRFAM: looped-hinge helix DNA binding domain, AbrB family.


ensembl_gene_id: ANME2D_00756
symbol: sucD
gene_biotype: protein_coding
description:
  succinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.


ensembl_gene_id: ANME2D_00757
symbol: sucC
gene_biotype: protein_coding
description:
  succinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.


ensembl_gene_id: ANME2D_00758
symbol: argF
gene_biotype: protein_coding
description:
  PFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; TIGRFAM: ornithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.


ensembl_gene_id: ANME2D_00765
symbol: nifK
gene_biotype: protein_coding
description:
  Nitrogenase molybdenum-iron protein; PFAM: Nitrogenase component 1 type Oxidoreductase; nitrogenase molybdenum-iron protein, alpha and beta chains; Belongs to the NifD/NifK/NifE/NifN family.


ensembl_gene_id: ANME2D_00766
symbol: nifD
gene_biotype: protein_coding
description:
  PFAM: Nitrogenase component 1 type Oxidoreductase; TIGRFAM: nitrogenase component I, alpha chain; nitrogenase alpha chain; nitrogenase molybdenum-iron cofactor biosynthesis protein NifE.


ensembl_gene_id: ANME2D_00769
symbol: nifH
gene_biotype: protein_coding
description:
  Mo-nitrogenase iron protein subunit NifH; The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein; Belongs to the NifH/BchL/ChlL family.


ensembl_gene_id: ANME2D_00770
symbol: KCZ73697.1
gene_biotype: protein_coding
description:
  phenylalanyl-tRNA synthetase, alpha subunit; PFAM: tRNA synthetases class II core domain (F); TIGRFAM: phenylalanyl-tRNA synthetase, alpha subunit.


ensembl_gene_id: ANME2D_00773
symbol: rpl10e
gene_biotype: protein_coding
description:
  PFAM: Ribosomal protein L16p/L10e; TIGRFAM: ribosomal protein L10.e; Belongs to the universal ribosomal protein uL16 family.


ensembl_gene_id: ANME2D_00774
symbol: eif2b
gene_biotype: protein_coding
description:
  Putative translation initiation factor 2 subunit beta (aeIF-2b); eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-beta/eIF-5 family.


ensembl_gene_id: ANME2D_00780
symbol: KCZ73707.1
gene_biotype: protein_coding
description:
  TATA-box binding protein (TBP), component of TFIID and TFIIIB; PFAM: Transcription factor TFIID (or TATA-binding protein, TBP).


ensembl_gene_id: ANME2D_00781
symbol: hisF
gene_biotype: protein_coding
description:
  Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.


ensembl_gene_id: ANME2D_00785
symbol: KCZ72358.1
gene_biotype: protein_coding
description:
  PFAM: PUA domain; Patch-forming domain C2 of tRNA-guanine transglycosylase; Queuine tRNA-ribosyltransferase; TIGRFAM: tRNA-guanine family transglycosylase; uncharacterized domain 2.


ensembl_gene_id: ANME2D_00788
symbol: tgtA
gene_biotype: protein_coding
description:
  Archaeosine tRNA-ribosyltransferase; Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs; Belongs to the archaeosine tRNA-ribosyltransferase family.


ensembl_gene_id: ANME2D_00796
symbol: hisH
gene_biotype: protein_coding
description:
  Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.


ensembl_gene_id: ANME2D_00797
symbol: KCZ72370.1
gene_biotype: protein_coding
description:
  Hydrogenase maturation factor; PFAM: AIR synthase related protein, N-terminal domain; AIR synthase related protein, C-terminal domain.


ensembl_gene_id: ANME2D_00803
symbol: gdhA
gene_biotype: protein_coding
description:
  PFAM: Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.


ensembl_gene_id: ANME2D_00804
symbol: KCZ72377.1
gene_biotype: protein_coding
description:
  acetyl-CoA synthetase (ADP-forming) alpha subunit; PFAM: CoA binding domain; Succinyl-CoA ligase like flavodoxin domain; TIGRFAM: acetyl coenzyme A synthetase (ADP forming), alpha domain.


ensembl_gene_id: ANME2D_00807
symbol: KCZ72380.1
gene_biotype: protein_coding
description:
  Putative exonuclease of the beta-lactamase fold involved in RNA processing; PFAM: Beta-lactamase superfamily domain.


ensembl_gene_id: ANME2D_00811
symbol: KCZ72384.1
gene_biotype: protein_coding
description:
  2, 5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine 1'-reductase; PFAM: RibD C-terminal domain; TIGRFAM: riboflavin-specific deaminase C-terminal domain; 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine 1'-reductase, archaeal.


ensembl_gene_id: ANME2D_00816
symbol: cobD
gene_biotype: protein_coding
description:
  Adenosylcobinamide-phosphate synthase; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.


ensembl_gene_id: ANME2D_00817
symbol: KCZ72390.1
gene_biotype: protein_coding
description:
  L-threonine O-3-phosphate decarboxylase; PFAM: Aminotransferase class I and II; Cysteine-rich small domain; TIGRFAM: L-threonine-O-3-phosphate decarboxylase; histidinol-phosphate aminotransferase.


ensembl_gene_id: ANME2D_00825
symbol: KCZ72398.1
gene_biotype: protein_coding
description:
  PFAM: Cytochrome C biogenesis protein; uncharacterized protein involved in biosynthesis of c-type cytochromes.


ensembl_gene_id: ANME2D_00835
symbol: taw
gene_biotype: protein_coding
description:
  Wyosine biosynthesis protein TYW1; Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).


ensembl_gene_id: ANME2D_00839
symbol: thi4
gene_biotype: protein_coding
description:
  Thiazole biosynthesis enzyme; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.


ensembl_gene_id: ANME2D_00841
symbol: valS
gene_biotype: protein_coding
description:
  valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.


ensembl_gene_id: ANME2D_00844
symbol: gap
gene_biotype: protein_coding
description:
  PFAM: Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type II.


ensembl_gene_id: ANME2D_00849
symbol: KCZ72422.1
gene_biotype: protein_coding
description:
  PFAM: 2Fe-2S iron-sulfur cluster binding domain; 4Fe-4S dicluster domain; TIGRFAM: succinate dehydrogenase and fumarate reductase iron-sulfur protein.


ensembl_gene_id: ANME2D_00850
symbol: KCZ72423.1
gene_biotype: protein_coding
description:
  PFAM: FAD binding domain; Fumarate reductase flavoprotein C-term; TIGRFAM: succinate dehydrogenase or fumarate reductase, flavoprotein subunitGram-negative/mitochondrial subgroup.


ensembl_gene_id: ANME2D_00851
symbol: KCZ72424.1
gene_biotype: protein_coding
description:
  Succinate dehydrogenase, hydrophobic anchor subunit; PFAM: Succinate dehydrogenase/Fumarate reductase transmembrane subunit.


ensembl_gene_id: ANME2D_00852
symbol: KCZ72425.1
gene_biotype: protein_coding
description:
  PFAM: Succinate dehydrogenase/Fumarate reductase transmembrane subunit; TIGRFAM: succinate dehydrogenase, cytochrome b556 subunit.


ensembl_gene_id: ANME2D_00853
symbol: KCZ72426.1
gene_biotype: protein_coding
description:
  PFAM: Tetrahydromethanopterin S-methyltransferase, subunit E; TIGRFAM: N5-methyltetrahydromethanopterin:coenzyme M methyltransferase subunit E.


ensembl_gene_id: ANME2D_00854
symbol: KCZ72427.1
gene_biotype: protein_coding
description:
  PFAM: Tetrahydromethanopterin S-methyltransferase, subunit D; TIGRFAM: N5-methyltetrahydromethanopterin:coenzyme M methyltransferase subunit D.


ensembl_gene_id: ANME2D_00856
symbol: KCZ72429.1
gene_biotype: protein_coding
description:
  PFAM: Tetrahydromethanopterin S-methyltransferase subunit B; TIGRFAM: tetrahydromethanopterin S-methyltransferase, subunit B.


ensembl_gene_id: ANME2D_00857
symbol: KCZ72430.1
gene_biotype: protein_coding
description:
  PFAM: Tetrahydromethanopterin S-methyltransferase, subunit A; TIGRFAM: N5-methyltetrahydromethanopterin:coenzyme M methyltransferase subunit A; tetrahydromethanopterin S-methyltransferase, F subunit.


ensembl_gene_id: ANME2D_00859
symbol: KCZ72432.1
gene_biotype: protein_coding
description:
  PFAM: Tetrahydromethanopterin S-methyltransferase, subunit G; TIGRFAM: N5-methyltetrahydromethanopterin:coenzyme M methyltransferase subunit G.


ensembl_gene_id: ANME2D_00863
symbol: KCZ72436.1
gene_biotype: protein_coding
description:
  CTP synthase; PFAM: Glutamine amidotransferase class-I; CTP synthase N-terminus; TIGRFAM: CTP synthase.


ensembl_gene_id: ANME2D_00867
symbol: KCZ72440.1
gene_biotype: protein_coding
description:
  Nitrate reductase cytochrome c-type subunit (NapB)/NapC/NirT cytochrome c family, N-terminal region; PFAM: Cytochrome c554 and c-prime.


ensembl_gene_id: ANME2D_00868
symbol: KCZ72441.1
gene_biotype: protein_coding
description:
  PFAM: Transmembrane exosortase (Exosortase_EpsH); TIGRFAM: exosortase/archaeosortase family protein; exosortase.


ensembl_gene_id: ANME2D_00871
symbol: aksA
gene_biotype: protein_coding
description:
  Isopropylmalate/homocitrate/citramalate synthase; PFAM: HMGL-like; Belongs to the alpha-IPM synthase/homocitrate synthase family.


ensembl_gene_id: ANME2D_00873
symbol: KCZ72446.1
gene_biotype: protein_coding
description:
  Uncharacterized protein, gamma-carboxymuconolactone decarboxylase subunit like protein; PFAM: Carboxymuconolactone decarboxylase family; TIGRFAM: alkylhydroperoxidase AhpD family core domain.


ensembl_gene_id: ANME2D_00875
symbol: mcrC
gene_biotype: protein_coding
description:
  PFAM: Methyl-coenzyme M reductase operon protein C; TIGRFAM: methyl-coenzyme M reductase I operon protein C.


ensembl_gene_id: ANME2D_00881
symbol: KCZ72454.1
gene_biotype: protein_coding
description:
  Archaeosortase C, PEF-CTERM variant; PFAM: Transmembrane exosortase (Exosortase_EpsH); TIGRFAM: exosortase/archaeosortase family protein; archaeosortase C, PEF-CTERM variant.


ensembl_gene_id: ANME2D_00885
symbol: KCZ72458.1
gene_biotype: protein_coding
description:
  Uncharacterized Fe-S center protein; PFAM: 4Fe-4S binding domain; Domain of unknown function (DUF362).


ensembl_gene_id: ANME2D_00910
symbol: KCZ72483.1
gene_biotype: protein_coding
description:
  Putative permease; PFAM: ABC-2 type transporter; TIGRFAM: daunorubicin resistance ABC transporter membrane protein; ABC-type polysaccharide/polyol phosphate export systems, permease component.


ensembl_gene_id: ANME2D_00912
symbol: rps19e
gene_biotype: protein_coding
description:
  Ribosomal protein S19E (S16A); May be involved in maturation of the 30S ribosomal subunit. Belongs to the eukaryotic ribosomal protein eS19 family.


ensembl_gene_id: ANME2D_00913
symbol: KCZ72486.1
gene_biotype: protein_coding
description:
  Putative RNA-binding protein containing KH domain, possibly ribosomal protein; PFAM: CRS1 / YhbY (CRM) domain.


ensembl_gene_id: ANME2D_00915
symbol: KCZ72488.1
gene_biotype: protein_coding
description:
  Small GTP-binding protein domain; PFAM: ADP-ribosylation factor family; KaiC; TIGRFAM: small GTP-binding protein domain.


ensembl_gene_id: ANME2D_00919
symbol: purD
gene_biotype: protein_coding
description:
  Phosphoribosylamine--glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, N domain; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, C domain; TIGRFAM: phosphoribosylamine--glycine ligase; Belongs to the GARS family.


ensembl_gene_id: ANME2D_00920
symbol: secG
gene_biotype: protein_coding
description:
  Preprotein translocase subunit Sec61beta; Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.


ensembl_gene_id: ANME2D_00923
symbol: rps17e
gene_biotype: protein_coding
description:
  Ribosomal protein S17E; PFAM: Ribosomal S17; Belongs to the eukaryotic ribosomal protein eS17 family.


ensembl_gene_id: ANME2D_00924
symbol: dapA
gene_biotype: protein_coding
description:
  Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).


ensembl_gene_id: ANME2D_00925
symbol: dapB
gene_biotype: protein_coding
description:
  Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family.


ensembl_gene_id: ANME2D_00936
symbol: mfnB
gene_biotype: protein_coding
description:
  Hypothetical protein; Catalyzes the formation of 4-(hydroxymethyl)-2- furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P).


ensembl_gene_id: ANME2D_00937
symbol: mqnE
gene_biotype: protein_coding
description:
  FO synthase subunit 2; PFAM: Radical SAM superfamily; TIGRFAM: putative menaquinone biosynthesis protein, SCO4494 family; 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, CofH subunit; radical SAM domain protein, CofH subfamily.


ensembl_gene_id: ANME2D_00942
symbol: map
gene_biotype: protein_coding
description:
  Methionine aminopeptidase, type II; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val); Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.


ensembl_gene_id: ANME2D_00945
symbol: KCZ72517.1
gene_biotype: protein_coding
description:
  Magnesium-translocating P-type ATPase; PFAM: E1-E2 ATPase; Cation transporting ATPase, C-terminus; haloacid dehalogenase-like hydrolase; Cation transporter/ATPase, N-terminus; TIGRFAM: ATPase, P-type (transporting), HAD superfamily, subfamily IC; magnesium-translocating P-type ATPase.


ensembl_gene_id: ANME2D_00949
symbol: mqnC
gene_biotype: protein_coding
description:
  De-hypoxanthine futalosine cyclase; Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2).


ensembl_gene_id: ANME2D_00950
symbol: KCZ72522.1
gene_biotype: protein_coding
description:
  Dihydropteroate synthase-related protein; PFAM: Domain of unknown function (DUF4346); Pterin binding enzyme; TIGRFAM: dihydropteroate synthase-related protein.


ensembl_gene_id: ANME2D_00954
symbol: ef1b
gene_biotype: protein_coding
description:
  Translation elongation factor 1B (aEF-1B); Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA.


ensembl_gene_id: ANME2D_00955
symbol: KCZ72526.1
gene_biotype: protein_coding
description:
  Putative Zn-ribbon RNA-binding protein with a function in translation; PFAM: Domain of unknown function (DUF1610).


ensembl_gene_id: ANME2D_00957
symbol: KCZ72528.1
gene_biotype: protein_coding
description:
  Translation initiation factor 2B subunit I family (IF-2BI); Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.


ensembl_gene_id: ANME2D_00963
symbol: fpoN
gene_biotype: protein_coding
description:
  F420H2 dehydrogenase subunit N; PFAM: NADH-Ubiquinone/plastoquinone (complex I), various chains; TIGRFAM: proton-translocating NADH-quinone oxidoreductase, chain N.


ensembl_gene_id: ANME2D_00964
symbol: fpoM
gene_biotype: protein_coding
description:
  PFAM: NADH-Ubiquinone/plastoquinone (complex I), various chains; TIGRFAM: proton-translocating NADH-quinone oxidoreductase, chain M.


ensembl_gene_id: ANME2D_00965
symbol: fpoL
gene_biotype: protein_coding
description:
  F420H2 dehydrogenase subunit L; PFAM: NADH-Ubiquinone/plastoquinone (complex I), various chains; NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; TIGRFAM: proton-translocating NADH-quinone oxidoreductase, chain L.


ensembl_gene_id: ANME2D_00966
symbol: fpoK
gene_biotype: protein_coding
description:
  NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K); PFAM: NADH-ubiquinone/plastoquinone oxidoreductase chain 4L.


ensembl_gene_id: ANME2D_00968
symbol: KCZ72539.1
gene_biotype: protein_coding
description:
  NADH:ubiquinone oxidoreductase subunit 6 (chain J); PFAM: NADH-ubiquinone/plastoquinone oxidoreductase chain 6.


ensembl_gene_id: ANME2D_00970
symbol: nuoH
gene_biotype: protein_coding
description:
  NADH:ubiquinone oxidoreductase subunit 1 (chain H); FPO shuttles electrons from F(420)H(2), via FAD and iron- sulfur (Fe-S) centers, to quinones in the F(420)H(2):heterodisulfide oxidoreduction chain. The immediate electron acceptor for the enzyme in this species is believed to be methanophenazine. Couples the redox reaction to proton translocation (for every two electrons transferred, 0.9 hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.


ensembl_gene_id: ANME2D_00971
symbol: nuoD
gene_biotype: protein_coding
description:
  PFAM: Respiratory-chain NADH dehydrogenase, 49 Kd subunit; TIGRFAM: NADH dehydrogenase I, D subunit; Belongs to the complex I 49 kDa subunit family.


ensembl_gene_id: ANME2D_00972
symbol: KCZ72543.1
gene_biotype: protein_coding
description:
  PFAM: Respiratory-chain NADH dehydrogenase, 30 Kd subunit; TIGRFAM: NADH (or F420H2) dehydrogenase, subunit C.


ensembl_gene_id: ANME2D_00973
symbol: KCZ72544.1
gene_biotype: protein_coding
description:
  PFAM: NADH ubiquinone oxidoreductase, 20 Kd subunit; TIGRFAM: NADH-quinone oxidoreductase, B subunit; Belongs to the complex I 20 kDa subunit family.


ensembl_gene_id: ANME2D_00974
symbol: nuoA
gene_biotype: protein_coding
description:
  NADH:ubiquinone oxidoreductase subunit 3 (chain A); PFAM: NADH-ubiquinone/plastoquinone oxidoreductase, chain 3.


ensembl_gene_id: ANME2D_00976
symbol: KCZ72547.1
gene_biotype: protein_coding
description:
  Putative methanogenesis marker domain 9; PFAM: Dihydrouridine synthase (Dus); TIGRFAM: TIM-barrel protein, putative; putative methanogenesis marker domain 9.


ensembl_gene_id: ANME2D_00977
symbol: KCZ72548.1
gene_biotype: protein_coding
description:
  Putative Zn-finger containing protein; PFAM: Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27).


ensembl_gene_id: ANME2D_00981
symbol: polB
gene_biotype: protein_coding
description:
  Archaeal DNA polymerase II, small subunit/DNA polymerase delta, subunit B; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family.


ensembl_gene_id: ANME2D_00982
symbol: KCZ72553.1
gene_biotype: protein_coding
description:
  PMT family glycosyltransferase, 4-amino-4-deoxy-L-arabinose transferase; PFAM: Dolichyl-phosphate-mannose-protein mannosyltransferase.


ensembl_gene_id: ANME2D_00985
symbol: hemC
gene_biotype: protein_coding
description:
  Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.


ensembl_gene_id: ANME2D_00986
symbol: KCZ72557.1
gene_biotype: protein_coding
description:
  uroporphyrin-III C-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family.


ensembl_gene_id: ANME2D_00989
symbol: KCZ72560.1
gene_biotype: protein_coding
description:
  Uncharacterized radical SAM protein YgiQ; PFAM: Domain of unknown function (DUF3362); Radical SAM superfamily; Radical SAM N-terminal; TIGRFAM: uncharacterized radical SAM protein YgiQ.


ensembl_gene_id: ANME2D_00992
symbol: cobZ
gene_biotype: protein_coding
description:
  Alpha-ribazole phosphatase CobZ; PFAM: Phosphatidylglycerophosphatase A; TIGRFAM: alpha-ribazole phosphatase CobZ.


ensembl_gene_id: ANME2D_00993
symbol: cobS
gene_biotype: protein_coding
description:
  Cobalamin-5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family.


ensembl_gene_id: ANME2D_00994
symbol: KCZ72565.1
gene_biotype: protein_coding
description:
  GTP:adenosylcobinamide-phosphate guanylyltransferase; PFAM: MobA-like NTP transferase domain; TIGRFAM: TIGR00454 family protein.


ensembl_gene_id: ANME2D_00998
symbol: KCZ72569.1
gene_biotype: protein_coding
description:
  Putative transcriptional regulator; PFAM: CBS domain; ParB-like nuclease domain; putative transcriptional regulator containing CBS domains.


ensembl_gene_id: ANME2D_00999
symbol: KCZ72570.1
gene_biotype: protein_coding
description:
  Putative transcriptional regulator; PFAM: CBS domain; Winged helix-turn-helix transcription repressor, HrcA DNA-binding; putative transcriptional regulator, contains C-terminal CBS domains.


ensembl_gene_id: ANME2D_01000
symbol: hpsA
gene_biotype: protein_coding
description:
  PFAM: Demethylmenaquinone methyltransferase; Orotidine 5'-phosphate decarboxylase / HUMPS family; TIGRFAM: 3-hexulose-6-phosphate synthase.


ensembl_gene_id: ANME2D_01002
symbol: dapF
gene_biotype: protein_coding
description:
  Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine.


ensembl_gene_id: ANME2D_01003
symbol: hisG
gene_biotype: protein_coding
description:
  ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily.


ensembl_gene_id: ANME2D_01007
symbol: pth
gene_biotype: protein_coding
description:
  peptidyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.


ensembl_gene_id: ANME2D_01009
symbol: hdrA
gene_biotype: protein_coding
description:
  Polyferredoxin, heterodixulfide reductase subunit A; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).


ensembl_gene_id: ANME2D_01012
symbol: uvrB
gene_biotype: protein_coding
description:
  Excinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate  [...]


ensembl_gene_id: ANME2D_01014
symbol: KCZ72585.1
gene_biotype: protein_coding
description:
  ATPase, type IV secretory pathway VirB11 component like protein; PFAM: Type II/IV secretion system protein.


ensembl_gene_id: ANME2D_01016
symbol: KCZ72587.1
gene_biotype: protein_coding
description:
  Cell division ATPase MinD, archaeal; PFAM: CobQ/CobB/MinD/ParA nucleotide binding domain; TIGRFAM: cell division ATPase MinD, archaeal.


ensembl_gene_id: ANME2D_01017
symbol: KCZ72588.1
gene_biotype: protein_coding
description:
  Phosphate ABC transporter substrate-binding protein, PhoT family; PFAM: PBP superfamily domain; TIGRFAM: phosphate binding protein.


ensembl_gene_id: ANME2D_01022
symbol: ablA
gene_biotype: protein_coding
description:
  PFAM: Lysine-2,3-aminomutase; Radical SAM superfamily; TIGRFAM: KamA family protein; lysine-2,3-aminomutase.


ensembl_gene_id: ANME2D_01024
symbol: KCZ72595.1
gene_biotype: protein_coding
description:
  Phosphoribosylamine--glycine ligase; PFAM: Phosphoribosylglycinamide synthetase, N domain; Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Phosphoribosylglycinamide synthetase, C domain; TIGRFAM: phosphoribosylamine--glycine ligase.


ensembl_gene_id: ANME2D_01026
symbol: KCZ72597.1
gene_biotype: protein_coding
description:
  KamA family protein; PFAM: Radical SAM superfamily; 4Fe-4S single cluster domain; TIGRFAM: KamA family protein.


ensembl_gene_id: ANME2D_01030
symbol: cutA
gene_biotype: protein_coding
description:
  Hypothetical protein; PFAM: CutA1 divalent ion tolerance protein; uncharacterized protein involved in tolerance to divalent cations.


ensembl_gene_id: ANME2D_01032
symbol: KCZ72603.1
gene_biotype: protein_coding
description:
  PFAM: Sec-independent protein translocase protein (TatC); TIGRFAM: Twin arginine targeting (Tat) protein translocase TatC.


ensembl_gene_id: ANME2D_01033
symbol: KCZ72604.1
gene_biotype: protein_coding
description:
  PFAM: Homoserine dehydrogenase, NAD binding domain; Domain of unknown function DUF108; TIGRFAM: aspartate dehydrogenase.


ensembl_gene_id: ANME2D_01034
symbol: nadC
gene_biotype: protein_coding
description:
  Nicotinate-nucleotide pyrophosphorylase (carboxylating); Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family.


ensembl_gene_id: ANME2D_01040
symbol: KCZ72610.1
gene_biotype: protein_coding
description:
  PFAM: Haloacid dehalogenase-like hydrolase; TIGRFAM: haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED.


ensembl_gene_id: ANME2D_01041
symbol: KCZ72611.1
gene_biotype: protein_coding
description:
  Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation); PFAM: Bacterial capsule synthesis protein PGA_cap.


ensembl_gene_id: ANME2D_01044
symbol: cysS
gene_biotype: protein_coding
description:
  PFAM: tRNA synthetases class I (C) catalytic domain; DALR domain; TIGRFAM: cysteinyl-tRNA synthetase.


ensembl_gene_id: ANME2D_01048
symbol: eIF5A
gene_biotype: protein_coding
description:
  Translation initiation factor 5A precursor (eIF-5A); Functions by promoting the formation of the first peptide bond; Belongs to the eIF-5A family.


ensembl_gene_id: ANME2D_01057
symbol: tyrS
gene_biotype: protein_coding
description:
  tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 3 subfamily.


ensembl_gene_id: ANME2D_01058
symbol: KCZ72628.1
gene_biotype: protein_coding
description:
  DNA/RNA helicase, superfamily II; PFAM: Helicase conserved C-terminal domain; DEAD/DEAH box helicase.


ensembl_gene_id: ANME2D_01059
symbol: KCZ72629.1
gene_biotype: protein_coding
description:
  Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB; PFAM: 2-hydroxyglutaryl-CoA dehydratase, D-component.


ensembl_gene_id: ANME2D_01061
symbol: KCZ72941.1
gene_biotype: protein_coding
description:
  Mg-chelatase subunit ChlD; PFAM: von Willebrand factor type A domain; coding region disrupted by sequencing gap.


ensembl_gene_id: ANME2D_01075
symbol: KCZ72644.1
gene_biotype: protein_coding
description:
  Ribulose-5-phosphate 4-epimerase-like epimerase or aldolase; PFAM: Class II Aldolase and Adducin N-terminal domain.


ensembl_gene_id: ANME2D_01077
symbol: nth
gene_biotype: protein_coding
description:
  Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.


ensembl_gene_id: ANME2D_01085
symbol: KCZ72654.1
gene_biotype: protein_coding
description:
  RecA-superfamily ATPase possibly involved in signal transduction; PFAM: KaiC; TIGRFAM: KaiC domain protein, AF_0351 family.


ensembl_gene_id: ANME2D_01090
symbol: pyrK
gene_biotype: protein_coding
description:
  2-polyprenylphenol hydroxylase-like oxidoreductase; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).


ensembl_gene_id: ANME2D_01091
symbol: KCZ72660.1
gene_biotype: protein_coding
description:
  NAD(P)H-nitrite reductase; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain.


ensembl_gene_id: ANME2D_01101
symbol: mcrB
gene_biotype: protein_coding
description:
  PFAM: Methyl-coenzyme M reductase beta subunit, C-terminal domain; Methyl-coenzyme M reductase beta subunit, N-terminal domain; TIGRFAM: methyl-coenzyme M reductase, beta subunit.


ensembl_gene_id: ANME2D_01102
symbol: mcrD
gene_biotype: protein_coding
description:
  PFAM: Methyl-coenzyme M reductase operon protein D; TIGRFAM: methyl-coenzyme M reductase operon protein D.


ensembl_gene_id: ANME2D_01103
symbol: mcrG
gene_biotype: protein_coding
description:
  PFAM: Methyl-coenzyme M reductase gamma subunit; TIGRFAM: methyl-coenzyme M reductase, gamma subunit.


ensembl_gene_id: ANME2D_01104
symbol: mcrA
gene_biotype: protein_coding
description:
  PFAM: Methyl-coenzyme M reductase alpha subunit, N-terminal domain; Methyl-coenzyme M reductase alpha subunit, C-terminal domain; TIGRFAM: methyl-coenzyme M reductase, alpha subunit.


ensembl_gene_id: ANME2D_01108
symbol: KCZ72677.1
gene_biotype: protein_coding
description:
  Nucleoside-diphosphate-sugar pyrophosphorylase family protein; PFAM: Nucleotidyl transferase; Bacterial transferase hexapeptide (six repeats); TIGRFAM: glucose-1-phosphate thymidylylransferase, long form.


ensembl_gene_id: ANME2D_01109
symbol: rpiA
gene_biotype: protein_coding
description:
  Ribose-5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.


ensembl_gene_id: ANME2D_01110
symbol: atsB
gene_biotype: protein_coding
description:
  PFAM: Iron-sulfur cluster-binding domain; Radical SAM superfamily; 4Fe-4S single cluster domain; TIGRFAM: putative peptide-modifying radical SAM enzyme, Mhun_1560 family; radical SAM additional 4Fe4S-binding SPASM domain.


ensembl_gene_id: ANME2D_01114
symbol: KCZ72683.1
gene_biotype: protein_coding
description:
  Putative methanogenesis marker protein 7; PFAM: Methyl-coenzyme M reductase operon protein C; TIGRFAM: putative methanogenesis marker protein 7.


ensembl_gene_id: ANME2D_01115
symbol: KCZ72684.1
gene_biotype: protein_coding
description:
  Putative methanogenesis marker protein 17; PFAM: Uncharacterized protein conserved in archaea (DUF2113); TIGRFAM: putative methanogenesis marker protein 17.


ensembl_gene_id: ANME2D_01116
symbol: KCZ72685.1
gene_biotype: protein_coding
description:
  Putative methanogenesis marker protein 15; PFAM: BadF/BadG/BcrA/BcrD ATPase family; TIGRFAM: CoA-substrate-specific enzyme activase, putative; putative methanogenesis marker protein 15.


ensembl_gene_id: ANME2D_01117
symbol: KCZ72686.1
gene_biotype: protein_coding
description:
  Putative methanogenesis marker protein 5; PFAM: Uncharacterized protein conserved in archaea (DUF2112); TIGRFAM: putative methanogenesis marker protein 5.


ensembl_gene_id: ANME2D_01118
symbol: KCZ72687.1
gene_biotype: protein_coding
description:
  Putative methanogenesis marker protein 6; PFAM: Uncharacterized protein conserved in archaea (DUF2102); TIGRFAM: putative methanogenesis marker protein 6.


ensembl_gene_id: ANME2D_01122
symbol: KCZ72691.1
gene_biotype: protein_coding
description:
  Hypothetical protein; Probable pre-rRNA processing protein involved in ribosome biogenesis; Belongs to the TSR3 family.


ensembl_gene_id: ANME2D_01146
symbol: KCZ72714.1
gene_biotype: protein_coding
description:
  PFAM: Carboxymuconolactone decarboxylase family; TIGRFAM: alkylhydroperoxidase AhpD family core domain.


ensembl_gene_id: ANME2D_01147
symbol: argG
gene_biotype: protein_coding
description:
  PFAM: Arginosuccinate synthase; TIGRFAM: argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily.


ensembl_gene_id: ANME2D_01151
symbol: KCZ72719.1
gene_biotype: protein_coding
description:
  PFAM: Biotin/lipoate A/B protein ligase family; TIGRFAM: lipoyltransferase and lipoate-protein ligase.


ensembl_gene_id: ANME2D_01152
symbol: KCZ72720.1
gene_biotype: protein_coding
description:
  Flavodoxin reductase family protein; PFAM: Oxidoreductase FAD-binding domain; Oxidoreductase NAD-binding domain.


ensembl_gene_id: ANME2D_01154
symbol: nodI
gene_biotype: protein_coding
description:
  ABC-type multidrug transport system, ATPase component; PFAM: ABC transporter; TIGRFAM: ATP-binding ABC transporter family nodulation protein NodI.


ensembl_gene_id: ANME2D_01155
symbol: KCZ72723.1
gene_biotype: protein_coding
description:
  Putative permease; PFAM: ABC-2 type transporter; TIGRFAM: ABC-2 type transporter, NodJ family; ABC-type polysaccharide/polyol phosphate export systems, permease component.


ensembl_gene_id: ANME2D_01159
symbol: mtnP
gene_biotype: protein_coding
description:
  5'-deoxy-5'-methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.


ensembl_gene_id: ANME2D_01162
symbol: tpiA
gene_biotype: protein_coding
description:
  Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family.


ensembl_gene_id: ANME2D_01164
symbol: rpoH
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerase, subunit H, RpoH/RPB5; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family.


ensembl_gene_id: ANME2D_01165
symbol: rpoB
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerase, beta subunit; PFAM: RNA polymerase Rpb2, domain 3; RNA polymerase Rpb2, domain 2; RNA polymerase beta subunit; Belongs to the RNA polymerase beta chain family.


ensembl_gene_id: ANME2D_01166
symbol: rpoB-2
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerase, subunit B; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.


ensembl_gene_id: ANME2D_01167
symbol: rpoA
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerase subunit A; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.


ensembl_gene_id: ANME2D_01168
symbol: rpoA-2
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerase, subunit A; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.


ensembl_gene_id: ANME2D_01170
symbol: nusA
gene_biotype: protein_coding
description:
  NusA family KH domain protein; Participates in transcription termination. Belongs to the NusA family.


ensembl_gene_id: ANME2D_01171
symbol: rps-5
gene_biotype: protein_coding
description:
  Ribosomal protein S23; With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits. Belongs to the universal ribosomal protein uS12 family.


ensembl_gene_id: ANME2D_01172
symbol: rps-6
gene_biotype: protein_coding
description:
  Ribosomal protein S7/S5; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center; Belongs to the universal ribosomal protein uS7 family.


ensembl_gene_id: ANME2D_01173
symbol: ribH
gene_biotype: protein_coding
description:
  6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.


ensembl_gene_id: ANME2D_01175
symbol: gltX
gene_biotype: protein_coding
description:
  glutamyl-tRNA synthetase, archaeal and eukaryotic family; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).


ensembl_gene_id: ANME2D_01192
symbol: xseA
gene_biotype: protein_coding
description:
  PFAM: Exonuclease VII, large subunit; OB-fold nucleic acid binding domain; TIGRFAM: exodeoxyribonuclease VII, large subunit.


ensembl_gene_id: ANME2D_01195
symbol: rnhB
gene_biotype: protein_coding
description:
  RNase HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.


ensembl_gene_id: ANME2D_01197
symbol: cdhA
gene_biotype: protein_coding
description:
  acetyl-CoA decarbonylase/synthase alpha subunit; Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase.


ensembl_gene_id: ANME2D_01198
symbol: cdhB
gene_biotype: protein_coding
description:
  acetyl-CoA decarbonylase/synthase epsilon subunit; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. The precise role of the epsilon subunit is unclear; it may have a stabilizing role within the alpha(2)epsilon(2) component and/or be involved in electron transfer to FAD during a potential FAD-mediated CO oxidation. Belongs to the CdhB family.


ensembl_gene_id: ANME2D_01199
symbol: cdhC
gene_biotype: protein_coding
description:
  acetyl-CoA decarbonylase/synthase beta subunit; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex); Belongs to the CdhC family.


ensembl_gene_id: ANME2D_01216
symbol: KCZ72781.1
gene_biotype: protein_coding
description:
  Type I restriction-modification system methyltransferase subunit; PFAM: N-6 DNA Methylase; HsdM N-terminal domain.


ensembl_gene_id: ANME2D_01225
symbol: KCZ72790.1
gene_biotype: protein_coding
description:
  PFAM: Type I restriction enzyme R protein N terminus (HSDR_N); Type III restriction enzyme, res subunit; TIGRFAM: type I site-specific deoxyribonuclease, HsdR family.


ensembl_gene_id: ANME2D_01228
symbol: nrdZ
gene_biotype: protein_coding
description:
  Ribonucleoside-diphosphate reductase class II; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.


ensembl_gene_id: ANME2D_01229
symbol: KCZ72794.1
gene_biotype: protein_coding
description:
  FeS cluster assembly scaffold protein NifU; PFAM: Pyridine nucleotide-disulphide oxidoreductase; NifU-like N terminal domain; TIGRFAM: FeS cluster assembly scaffold protein NifU, Clostridium type.


ensembl_gene_id: ANME2D_01232
symbol: KCZ72797.1
gene_biotype: protein_coding
description:
  Putative membrane protein; PFAM: Protein of unknown function (DUF996); Protein of unknown function (DUF1418).


ensembl_gene_id: ANME2D_01235
symbol: KCZ72800.1
gene_biotype: protein_coding
description:
  Periplasmic component of the Tol biopolymer transport system; PFAM: WD40-like Beta Propeller Repeat.


ensembl_gene_id: ANME2D_01252
symbol: KCZ72817.1
gene_biotype: protein_coding
description:
  Excinuclease ABC subunit C; PFAM: UvrB/uvrC motif; UvrC Helix-hairpin-helix N-terminal; Helix-hairpin-helix domain; GIY-YIG catalytic domain; TIGRFAM: excinuclease ABC, C subunit.


ensembl_gene_id: ANME2D_01253
symbol: KCZ72818.1
gene_biotype: protein_coding
description:
  PFAM: HAMP domain; Cache domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phospho-acceptor) domain.


ensembl_gene_id: ANME2D_01254
symbol: KCZ72819.1
gene_biotype: protein_coding
description:
  ABC-type nitrate/sulfonate/bicarbonate transport system, periplasmic component; PFAM: NMT1-like family; NMT1/THI5 like.


ensembl_gene_id: ANME2D_01255
symbol: uvrA
gene_biotype: protein_coding
description:
  Excinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.


ensembl_gene_id: ANME2D_01258
symbol: KCZ72823.1
gene_biotype: protein_coding
description:
  Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase; PFAM: Aminotransferase class-V.


ensembl_gene_id: ANME2D_01260
symbol: KCZ72825.1
gene_biotype: protein_coding
description:
  Putative PLP-dependent enzyme possibly involved in cell wall biogenesis; PFAM: DegT/DnrJ/EryC1/StrS aminotransferase family.


ensembl_gene_id: ANME2D_01261
symbol: KCZ72826.1
gene_biotype: protein_coding
description:
  UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase; PFAM: Bacterial transferase hexapeptide (six repeats).


ensembl_gene_id: ANME2D_01262
symbol: KCZ72827.1
gene_biotype: protein_coding
description:
  UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase; PFAM: Glycosyl transferase family 4.


ensembl_gene_id: ANME2D_01272
symbol: KCZ72837.1
gene_biotype: protein_coding
description:
  Membrane protein involved in the export of O-antigen and teichoic acid; PFAM: Polysaccharide biosynthesis protein.


ensembl_gene_id: ANME2D_01287
symbol: KCZ72852.1
gene_biotype: protein_coding
description:
  PFAM: CorA-like Mg2+ transporter protein; TIGRFAM: magnesium Mg(2+) and cobalt Co(2+) transport protein (corA).


ensembl_gene_id: ANME2D_01288
symbol: corA
gene_biotype: protein_coding
description:
  Hypothetical protein; Mediates influx of magnesium ions. Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.


ensembl_gene_id: ANME2D_01289
symbol: KCZ72854.1
gene_biotype: protein_coding
description:
  CBS domain-containing protein; PFAM: CBS domain; Domain of unknown function DUF21; Transporter associated domain.


ensembl_gene_id: ANME2D_01292
symbol: KCZ72857.1
gene_biotype: protein_coding
description:
  TIGR00341 family protein; PFAM: Domain of unknown function (DUF389); TIGRFAM: uncharacterized hydrophobic domain; TIGR00341 family protein.


ensembl_gene_id: ANME2D_01297
symbol: KCZ72862.1
gene_biotype: protein_coding
description:
  PFAM: Radical SAM superfamily; 4Fe-4S single cluster domain; TIGRFAM: radical SAM additional 4Fe4S-binding SPASM domain.


ensembl_gene_id: ANME2D_01304
symbol: KCZ72869.1
gene_biotype: protein_coding
description:
  PFAM: Type I restriction enzyme R protein N terminus (HSDR_N); Type III restriction enzyme, res subunit.


ensembl_gene_id: ANME2D_01311
symbol: truB
gene_biotype: protein_coding
description:
  Putative rRNA pseudouridine synthase; Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.


ensembl_gene_id: ANME2D_01314
symbol: adk
gene_biotype: protein_coding
description:
  Adenylate kinase family protein; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.


ensembl_gene_id: ANME2D_01317
symbol: KCZ72881.1
gene_biotype: protein_coding
description:
  ATPase component of various ABC-type transport systems with duplicated ATPase domain; PFAM: ABC transporter.


ensembl_gene_id: ANME2D_01321
symbol: cimA
gene_biotype: protein_coding
description:
  Isopropylmalate/citramalate/homocitrate synthase; Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate; Belongs to the alpha-IPM synthase/homocitrate synthase family.


ensembl_gene_id: ANME2D_01322
symbol: ilvI
gene_biotype: protein_coding
description:
  Acetolactate synthase, large subunit; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type.


ensembl_gene_id: ANME2D_01323
symbol: ilvH
gene_biotype: protein_coding
description:
  PFAM: Small subunit of acetolactate synthase; ACT domain; TIGRFAM: acetolactate synthase, small subunit.


ensembl_gene_id: ANME2D_01327
symbol: argB
gene_biotype: protein_coding
description:
  N-acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily.


ensembl_gene_id: ANME2D_01328
symbol: mptA
gene_biotype: protein_coding
description:
  TIGR00294 family protein; Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.


ensembl_gene_id: ANME2D_01344
symbol: KCZ72904.1
gene_biotype: protein_coding
description:
  Flp pilus assembly protein, protease CpaA; PFAM: Archaeal Peptidase A24 C-terminus Type II; Type IV leader peptidase family.


ensembl_gene_id: ANME2D_01352
symbol: KCZ72911.1
gene_biotype: protein_coding
description:
  PFAM: ubiE/COQ5 methyltransferase family; TIGRFAM: ubiquinone/menaquinone biosynthesis methyltransferases.


ensembl_gene_id: ANME2D_01353
symbol: KCZ72912.1
gene_biotype: protein_coding
description:
  Soluble P-type ATPase; PFAM: haloacid dehalogenase-like hydrolase; TIGRFAM: ATPase, P-type (transporting), HAD superfamily, subfamily IC.


ensembl_gene_id: ANME2D_01354
symbol: rsmA
gene_biotype: protein_coding
description:
  Dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.


ensembl_gene_id: ANME2D_01358
symbol: pus
gene_biotype: protein_coding
description:
  TIGR01213 family protein; Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.


ensembl_gene_id: ANME2D_01361
symbol: trmY
gene_biotype: protein_coding
description:
  Putative SAM-dependent RNA methyltransferase; Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs; Belongs to the methyltransferase superfamily. TrmY family.


ensembl_gene_id: ANME2D_01362
symbol: KCZ72921.1
gene_biotype: protein_coding
description:
  PAS domain S-box; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phospho-acceptor) domain; PAS domain; PAS fold; TIGRFAM: PAS domain S-box.


ensembl_gene_id: ANME2D_01363
symbol: KCZ72922.1
gene_biotype: protein_coding
description:
  PAS domain S-box; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phospho-acceptor) domain; PAS fold; TIGRFAM: PAS domain S-box.


ensembl_gene_id: ANME2D_01370
symbol: merA
gene_biotype: protein_coding
description:
  Dihydrolipoamide dehydrogenase/mercuric reductase; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; TIGRFAM: dihydrolipoamide dehydrogenase; mercuric reductase; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.


ensembl_gene_id: ANME2D_01371
symbol: KCZ72930.1
gene_biotype: protein_coding
description:
  SOS response transcriptional repressor, RecA-mediated autopeptidase; PFAM: LexA DNA binding domain; Alkylmercury lyase.


ensembl_gene_id: ANME2D_01380
symbol: KCZ72937.1
gene_biotype: protein_coding
description:
  PFAM: Reverse transcriptase (RNA-dependent DNA polymerase); N-terminal domain of reverse transcriptase.


ensembl_gene_id: ANME2D_01386
symbol: ubiX
gene_biotype: protein_coding
description:
  Polyprenyl p-hydroxybenzoate/phenylacrylic acid decarboxylase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family.


ensembl_gene_id: ANME2D_01387
symbol: KCZ71988.1
gene_biotype: protein_coding
description:
  UbiD family decarboxylase; PFAM: 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; TIGRFAM: UbiD family decarboxylase.


ensembl_gene_id: ANME2D_01391
symbol: KCZ71992.1
gene_biotype: protein_coding
description:
  Putative methanogenesis marker protein 8; PFAM: Universal stress protein family; Uncharacterized protein conserved in archaea (DUF2099); TIGRFAM: putative methanogenesis marker protein 8.


ensembl_gene_id: ANME2D_01392
symbol: KCZ71993.1
gene_biotype: protein_coding
description:
  PAS domain S-box; PFAM: Response regulator receiver domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phospho-acceptor) domain; PAS domain; PAS fold; TIGRFAM: PAS domain S-box.


ensembl_gene_id: ANME2D_01397
symbol: eif1a
gene_biotype: protein_coding
description:
  Translation initiation factor 1A (aeIF-1A); Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.


ensembl_gene_id: ANME2D_01398
symbol: kae
gene_biotype: protein_coding
description:
  Metallohydrolase, glycoprotease/Kae1 family; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.


ensembl_gene_id: ANME2D_01399
symbol: KCZ72000.1
gene_biotype: protein_coding
description:
  AMP phosphorylase; Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.


ensembl_gene_id: ANME2D_01419
symbol: KCZ72019.1
gene_biotype: protein_coding
description:
  PAS domain S-box; PFAM: Response regulator receiver domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phospho-acceptor) domain; PAS domain; TIGRFAM: PAS domain S-box.


ensembl_gene_id: ANME2D_01423
symbol: KCZ72023.1
gene_biotype: protein_coding
description:
  Cytotoxic translational repressor of toxin-antitoxin stability system; PFAM: Plasmid stabilisation system protein.


ensembl_gene_id: ANME2D_01429
symbol: KCZ72029.1
gene_biotype: protein_coding
description:
  PFAM: Protein of unknown function (DUF3375); signal transduction protein containing GAF and PtsI domains.


ensembl_gene_id: ANME2D_01431
symbol: KCZ72031.1
gene_biotype: protein_coding
description:
  Hypothetical protein; PFAM: Putative exonuclease SbcCD, C subunit; P-loop containing region of AAA domain.


ensembl_gene_id: ANME2D_01432
symbol: KCZ72032.1
gene_biotype: protein_coding
description:
  PFAM: Uncharacterized protein conserved in bacteria N-term (DUF3322); Uncharacterized protein conserved in bacteria C-term(DUF2220).


ensembl_gene_id: ANME2D_01435
symbol: KCZ72035.1
gene_biotype: protein_coding
description:
  Putative ATPase (AAA+ superfamily); PFAM: ATPase family associated with various cellular activities (AAA); Belongs to the AAA ATPase family.


ensembl_gene_id: ANME2D_01436
symbol: KCZ72036.1
gene_biotype: protein_coding
description:
  Methionine synthase II (cobalamin-independent); PFAM: Cobalamin-independent synthase, Catalytic domain.


ensembl_gene_id: ANME2D_01438
symbol: sat
gene_biotype: protein_coding
description:
  Sulfate adenylyltransferase; PFAM: PUA-like domain; ATP-sulfurylase; TIGRFAM: ATP sulphurylase; Belongs to the sulfate adenylyltransferase family.


ensembl_gene_id: ANME2D_01440
symbol: KCZ72039.1
gene_biotype: protein_coding
description:
  Phytoene dehydrogenase-like oxidoreductase; PFAM: NAD(P)-binding Rossmann-like domain; FAD dependent oxidoreductase.


ensembl_gene_id: ANME2D_01441
symbol: KCZ72040.1
gene_biotype: protein_coding
description:
  Putative RNA-binding protein, snRNP like protein; PFAM: Domain of unknown function (DUF814); Fibronectin-binding protein A N-terminus (FbpA).


ensembl_gene_id: ANME2D_01458
symbol: aroB
gene_biotype: protein_coding
description:
  Putative alternative 3-dehydroquinate synthase; Catalyzes the oxidative deamination and cyclization of 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis; Belongs to the archaeal-type DHQ synthase family.


ensembl_gene_id: ANME2D_01459
symbol: aroA
gene_biotype: protein_coding
description:
  Putative phospho-2-dehydro-3-deoxyheptonate aldolase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.


ensembl_gene_id: ANME2D_01461
symbol: pan-2
gene_biotype: protein_coding
description:
  26S proteasome subunit P45 family; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-2 [...]


ensembl_gene_id: ANME2D_01464
symbol: rpl-8
gene_biotype: protein_coding
description:
  LSU ribosomal protein L13P; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.


ensembl_gene_id: ANME2D_01465
symbol: rps-7
gene_biotype: protein_coding
description:
  PFAM: Ribosomal protein S9/S16; TIGRFAM: archaeal ribosomal protein S9P; Belongs to the universal ribosomal protein uS9 family.


ensembl_gene_id: ANME2D_01466
symbol: rpoN
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerase, subunit N (RpoN/RPB10); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoN/eukaryotic RPB10 RNA polymerase subunit family.


ensembl_gene_id: ANME2D_01468
symbol: rpoK
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerase, subunit K/omega; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoK/eukaryotic RPB6 RNA polymerase subunit family.


ensembl_gene_id: ANME2D_01469
symbol: rps-8
gene_biotype: protein_coding
description:
  PFAM: Ribosomal protein S2; TIGRFAM: ribosomal protein Sa(cytosolic)/S2(archaeal); Belongs to the universal ribosomal protein uS2 family.


ensembl_gene_id: ANME2D_01477
symbol: KCZ72075.1
gene_biotype: protein_coding
description:
  Molecular chaperone (small heat shock protein); PFAM: Hsp20/alpha crystallin family; Belongs to the small heat shock protein (HSP20) family.


ensembl_gene_id: ANME2D_01487
symbol: KCZ72085.1
gene_biotype: protein_coding
description:
  dTDP-glucose pyrophosphorylase; PFAM: Nucleotidyl transferase; TIGRFAM: glucose-1-phosphate thymidylylransferase, long form.


ensembl_gene_id: ANME2D_01488
symbol: xanB
gene_biotype: protein_coding
description:
  Mannose-1-phosphate guanylyltransferase (GDP); PFAM: Nucleotidyl transferase; Mannose-6-phosphate isomerase; TIGRFAM: mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; mannose-1-phosphate guanylyltransferase (GDP); mannose-6-phosphate isomerase, type 2.


ensembl_gene_id: ANME2D_01489
symbol: aglM
gene_biotype: protein_coding
description:
  Nucleotide sugar dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; UDP-glucose/GDP-mannose dehydrogenase family, central domain; UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; TIGRFAM: nucleotide sugar dehydrogenase.


ensembl_gene_id: ANME2D_01490
symbol: apgM
gene_biotype: protein_coding
description:
  PFAM: 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Metalloenzyme superfamily; TIGRFAM: 2,3-bisphosphoglycerate-independent phosphoglycerate mutase, archaeal form; proposed homoserine kinase.


ensembl_gene_id: ANME2D_01492
symbol: KCZ72090.1
gene_biotype: protein_coding
description:
  PAS domain S-box; PFAM: Bacterial regulatory protein, arsR family; GAF domain; PAS domain; TIGRFAM: PAS domain S-box.


ensembl_gene_id: ANME2D_01494
symbol: KCZ72092.1
gene_biotype: protein_coding
description:
  DNA polymerase IV (family X); PFAM: PHP domain; DNA polymerase beta thumb; Helix-hairpin-helix domain.


ensembl_gene_id: ANME2D_01502
symbol: top6A
gene_biotype: protein_coding
description:
  DNA topoisomerase VI, subunit A; Relaxes both positive and negative superturns and exhibits a strong decatenase activity; Belongs to the TOP6A family.


ensembl_gene_id: ANME2D_01503
symbol: top6B
gene_biotype: protein_coding
description:
  DNA topoisomerase VI, B subunit; Relaxes both positive and negative superturns and exhibits a strong decatenase activity.


ensembl_gene_id: ANME2D_01508
symbol: KCZ72106.1
gene_biotype: protein_coding
description:
  Pyruvate formate lyase activating protein-like uncharacterized Fe-S protein; PFAM: Radical SAM superfamily; 4Fe-4S single cluster domain.


ensembl_gene_id: ANME2D_01511
symbol: trpB
gene_biotype: protein_coding
description:
  Pyridoxal-phosphate dependent TrpB-like enzyme; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.


ensembl_gene_id: ANME2D_01516
symbol: trm
gene_biotype: protein_coding
description:
  PFAM: N2,N2-dimethylguanosine tRNA methyltransferase; TIGRFAM: tRNA(guanine-26,N2-N2) methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.


ensembl_gene_id: ANME2D_01517
symbol: KCZ72115.1
gene_biotype: protein_coding
description:
  Putative nucleotide kinase; Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency; Belongs to the THEP1 NTPase family.


ensembl_gene_id: ANME2D_01518
symbol: KCZ72116.1
gene_biotype: protein_coding
description:
  DNA polymerase elongation subunit (family B); PFAM: DNA polymerase family B; DNA polymerase family B, exonuclease domain.


ensembl_gene_id: ANME2D_01521
symbol: KCZ72118.1
gene_biotype: protein_coding
description:
  PFAM: Glutamine amidotransferase domain; Asparagine synthase; TIGRFAM: asparagine synthase (glutamine-hydrolyzing).


ensembl_gene_id: ANME2D_01523
symbol: hisS
gene_biotype: protein_coding
description:
  PFAM: Anticodon binding domain; Histidyl-tRNA synthetase; TIGRFAM: ATP phosphoribosyltransferase, regulatory subunit; histidyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family.


ensembl_gene_id: ANME2D_01530
symbol: KCZ72127.1
gene_biotype: protein_coding
description:
  PAS domain S-box; PFAM: Response regulator receiver domain; His Kinase A (phospho-acceptor) domain; PAS fold; TIGRFAM: PAS domain S-box.


ensembl_gene_id: ANME2D_01531
symbol: KCZ72128.1
gene_biotype: protein_coding
description:
  PFAM: Radical SAM superfamily; Protein of unknown function (DUF512); TIGRFAM: methanogenesis marker radical SAM protein.


ensembl_gene_id: ANME2D_01534
symbol: rlmE
gene_biotype: protein_coding
description:
  23S rRNA methylase; Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.


ensembl_gene_id: ANME2D_01543
symbol: leuS
gene_biotype: protein_coding
description:
  PFAM: tRNA synthetases class I (I, L, M and V); Anticodon-binding domain of tRNA; TIGRFAM: leucyl-tRNA synthetase, archaeal and cytosolic family; Belongs to the class-I aminoacyl-tRNA synthetase family.


ensembl_gene_id: ANME2D_01547
symbol: leuB-3
gene_biotype: protein_coding
description:
  PFAM: Isocitrate/isopropylmalate dehydrogenase; TIGRFAM: isopropylmalate/isohomocitrate dehydrogenases.


ensembl_gene_id: ANME2D_01549
symbol: hacB
gene_biotype: protein_coding
description:
  3-isopropylmalate dehydratase, small subunit; Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)- aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B; Belongs to the LeuD  [...]


ensembl_gene_id: ANME2D_01550
symbol: KCZ72147.1
gene_biotype: protein_coding
description:
  Subtilisin-like serine protease; PFAM: Peptidase inhibitor I9; Subtilase family; TIGRFAM: PGF-pre-PGF domain.


ensembl_gene_id: ANME2D_01556
symbol: KCZ72152.1
gene_biotype: protein_coding
description:
  Putative hydroxymethylglutaryl-CoA synthase; PFAM: Hydroxymethylglutaryl-coenzyme A synthase N terminal; 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal; TIGRFAM: hydroxymethylglutaryl-CoA synthase, putative; Belongs to the thiolase-like superfamily. UPF0219 family.


ensembl_gene_id: ANME2D_01558
symbol: KCZ72154.1
gene_biotype: protein_coding
description:
  Putative nucleic-acid-binding protein containing a Zn-ribbon; PFAM: Rubredoxin-like zinc ribbon domain (DUF35_N); DUF35 OB-fold domain.


ensembl_gene_id: ANME2D_01560
symbol: KCZ72156.1
gene_biotype: protein_coding
description:
  ABC-type nitrate/sulfonate/bicarbonate transport system, periplasmic component; PFAM: NMT1-like family.


ensembl_gene_id: ANME2D_01565
symbol: KCZ72161.1
gene_biotype: protein_coding
description:
  GDP-mannose 4,6-dehydratase; PFAM: NAD dependent epimerase/dehydratase family; TIGRFAM: GDP-mannose 4,6-dehydratase.


ensembl_gene_id: ANME2D_01568
symbol: KCZ72164.1
gene_biotype: protein_coding
description:
  Membrane protein involved in the export of O-antigen and teichoic acid; PFAM: Polysaccharide biosynthesis C-terminal domain; Polysaccharide biosynthesis protein.


ensembl_gene_id: ANME2D_01569
symbol: KCZ72165.1
gene_biotype: protein_coding
description:
  Methyltransferase, FkbM family; PFAM: Methyltransferase FkbM domain; TIGRFAM: methyltransferase, FkbM family.


ensembl_gene_id: ANME2D_01585
symbol: KCZ72181.1
gene_biotype: protein_coding
description:
  PFAM: Oligosaccharyl transferase STT3 subunit; TIGRFAM: oligosaccharyl transferase, archaeosortase A system-associated.


ensembl_gene_id: ANME2D_01588
symbol: KCZ72184.1
gene_biotype: protein_coding
description:
  PFAM: Molybdopterin guanine dinucleotide synthesis protein B; TIGRFAM: molybdopterin-guanine dinucleotide biosynthesis protein MobB.


ensembl_gene_id: ANME2D_01590
symbol: mobA
gene_biotype: protein_coding
description:
  Molybdopterin-guanine dinucleotide biosynthesis protein A; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.


ensembl_gene_id: ANME2D_01604
symbol: KCZ72200.1
gene_biotype: protein_coding
description:
  Putative dehydrogenase; PFAM: Oxidoreductase family, C-terminal alpha/beta domain; Oxidoreductase family, NAD-binding Rossmann fold.


ensembl_gene_id: ANME2D_01612
symbol: KCZ72208.1
gene_biotype: protein_coding
description:
  Glycosyltransferase; PFAM: Glycosyl transferase 4-like; Glycosyl transferases group 1; TIGRFAM: N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA.


ensembl_gene_id: ANME2D_01616
symbol: KCZ72212.1
gene_biotype: protein_coding
description:
  Putative transcriptional regulator with HTH domain; PFAM: Divergent AAA domain; ATP-dependent DNA helicase recG C-terminal.


ensembl_gene_id: ANME2D_01630
symbol: queC
gene_biotype: protein_coding
description:
  Queuosine biosynthesis protein QueC; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family.


ensembl_gene_id: ANME2D_01634
symbol: endA
gene_biotype: protein_coding
description:
  tRNA intron endonuclease; Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.


ensembl_gene_id: ANME2D_01635
symbol: KCZ72231.1
gene_biotype: protein_coding
description:
  PFAM: Translation initiation factor SUI1; TIGRFAM: translation initation factor SUI1, putative, prokaryotic; Belongs to the SUI1 family.


ensembl_gene_id: ANME2D_01636
symbol: mtd
gene_biotype: protein_coding
description:
  Coenzyme F420-dependent N(5),N(10)-methenyltetrahydromethanopterin dehydrogenase; Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.


ensembl_gene_id: ANME2D_01638
symbol: ribL
gene_biotype: protein_coding
description:
  Cytidyltransferase-related enzyme; Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.


ensembl_gene_id: ANME2D_01643
symbol: KCZ72239.1
gene_biotype: protein_coding
description:
  Putative methanogenesis marker protein 1; PFAM: YcaO-like family; TIGRFAM: uncharacterized domain; thiazole/oxazole-forming peptide maturase, SagD family component; putative methanogenesis marker protein 1.


ensembl_gene_id: ANME2D_01646
symbol: dph
gene_biotype: protein_coding
description:
  Diphthamide biosynthesis enzyme Dph2; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family.


ensembl_gene_id: ANME2D_01653
symbol: hisI
gene_biotype: protein_coding
description:
  phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.


ensembl_gene_id: ANME2D_01658
symbol: KCZ72253.1
gene_biotype: protein_coding
description:
  Putative ATPase (AAA+ superfamily); PFAM: Archaeal ATPase; Archaea bacterial proteins of unknown function.


ensembl_gene_id: ANME2D_01659
symbol: ileS
gene_biotype: protein_coding
description:
  Isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.


ensembl_gene_id: ANME2D_01661
symbol: KCZ72256.1
gene_biotype: protein_coding
description:
  Putative membrane protein; PFAM: Protein of unknown function DUF131; TIGRFAM: TIGR00304 family protein.


ensembl_gene_id: ANME2D_01662
symbol: KCZ72257.1
gene_biotype: protein_coding
description:
  TIGR00304 family protein; PFAM: Protein of unknown function DUF131; TIGRFAM: TIGR00304 family protein.


ensembl_gene_id: ANME2D_01663
symbol: KCZ72258.1
gene_biotype: protein_coding
description:
  PFAM: Phosphoadenosine phosphosulfate reductase family; TIGRFAM: thioredoxin-dependent adenylylsulfate APS reductase; phosophoadenylyl-sulfate reductase (thioredoxin); 5'-adenylylsulfate reductase, thioredoxin-independent.


ensembl_gene_id: ANME2D_01664
symbol: KCZ72259.1
gene_biotype: protein_coding
description:
  Putative 8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.


ensembl_gene_id: ANME2D_01697
symbol: KCZ72292.1
gene_biotype: protein_coding
description:
  Nitrous oxidase accessory protein; PFAM: Right handed beta helix region; Fibronectin type III domain; TIGRFAM: parallel beta-helix repeat (two copies).


ensembl_gene_id: ANME2D_01706
symbol: KCZ72301.1
gene_biotype: protein_coding
description:
  Asparagine synthase, glutamine-hydrolyzing; PFAM: Glutamine amidotransferase domain; Asparagine synthase; TIGRFAM: asparagine synthase (glutamine-hydrolyzing).


ensembl_gene_id: ANME2D_01707
symbol: KCZ72354.1
gene_biotype: protein_coding
description:
  Hypothetical protein; PFAM: Concanavalin A-like lectin/glucanases superfamily; coding region disrupted by sequencing gap.


ensembl_gene_id: ANME2D_01708
symbol: KCZ72302.1
gene_biotype: protein_coding
description:
  Hypothetical protein; PFAM: Concanavalin A-like lectin/glucanases superfamily; GDSL-like Lipase/Acylhydrolase family.


ensembl_gene_id: ANME2D_01712
symbol: KCZ72306.1
gene_biotype: protein_coding
description:
  Acetyltransferase (isoleucine patch superfamily); PFAM: Bacterial transferase hexapeptide (six repeats).


ensembl_gene_id: ANME2D_01716
symbol: KCZ72310.1
gene_biotype: protein_coding
description:
  PDK repeat-containing protein; PFAM: Putative collagen-binding domain of a collagenase; Cohesin domain; Protein of unknown function (DUF4038); PKD domain.


ensembl_gene_id: ANME2D_01719
symbol: mfnA
gene_biotype: protein_coding
description:
  Tyrosine decarboxylase MnfA; Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis; Belongs to the group II decarboxylase family. MfnA subfamily.


ensembl_gene_id: ANME2D_01721
symbol: mdh
gene_biotype: protein_coding
description:
  PFAM: lactate/malate dehydrogenase, alpha/beta C-terminal domain; lactate/malate dehydrogenase, NAD binding domain; TIGRFAM: malate dehydrogenase, NAD-dependent; Belongs to the LDH/MDH superfamily.


ensembl_gene_id: ANME2D_01722
symbol: KCZ72316.1
gene_biotype: protein_coding
description:
  Histidine kinase,histidine kinase,CHASE domain-containing protein; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phospho-acceptor) domain; CHASE domain.


ensembl_gene_id: ANME2D_01730
symbol: gatC
gene_biotype: protein_coding
description:
  glutamyl-tRNA(Gln) and/or aspartyl-tRNA(Asn) amidotransferase, C subunit; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatC family.


ensembl_gene_id: ANME2D_01731
symbol: gatA
gene_biotype: protein_coding
description:
  glutamyl-tRNA(Gln) and/or aspartyl-tRNA(Asn) amidotransferase, A subunit; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln).


ensembl_gene_id: ANME2D_01732
symbol: gatB
gene_biotype: protein_coding
description:
  glutamyl-tRNA(Gln) and/or aspartyl-tRNA(Asn) amidotransferase, B subunit; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily.


ensembl_gene_id: ANME2D_01733
symbol: rpl15e
gene_biotype: protein_coding
description:
  Ribosomal protein L15E; PFAM: Ribosomal L15; Belongs to the eukaryotic ribosomal protein eL15 family.


ensembl_gene_id: ANME2D_01744
symbol: pyrC
gene_biotype: protein_coding
description:
  Dihydroorotase, multifunctional complex type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.


ensembl_gene_id: ANME2D_01756
symbol: gatE
gene_biotype: protein_coding
description:
  glutamyl-tRNA(Gln) amidotransferase, subunit E; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.


ensembl_gene_id: ANME2D_01760
symbol: KCZ71706.1
gene_biotype: protein_coding
description:
  Bacteriophytochrome (light-regulated signal transduction histidine kinase); PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Response regulator receiver domain; His Kinase A (phospho-acceptor) domain.


ensembl_gene_id: ANME2D_01761
symbol: KCZ71707.1
gene_biotype: protein_coding
description:
  Putative ATPase; PFAM: Histidine kinase; Protein kinase domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; GAF domain; AAA ATPase domain.


ensembl_gene_id: ANME2D_01765
symbol: KCZ71711.1
gene_biotype: protein_coding
description:
  Bacteriophytochrome (light-regulated signal transduction histidine kinase); PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; GAF domain; His Kinase A (phospho-acceptor) domain.


ensembl_gene_id: ANME2D_01768
symbol: proC
gene_biotype: protein_coding
description:
  Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.


ensembl_gene_id: ANME2D_01769
symbol: lysA
gene_biotype: protein_coding
description:
  Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine.


ensembl_gene_id: ANME2D_01772
symbol: KCZ71718.1
gene_biotype: protein_coding
description:
  NAD(FAD)-dependent dehydrogenase; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain.


ensembl_gene_id: ANME2D_01774
symbol: KCZ71720.1
gene_biotype: protein_coding
description:
  P-type ATPase, translocating; PFAM: E1-E2 ATPase; Cation transporting ATPase, C-terminus; haloacid dehalogenase-like hydrolase; Cation transporter/ATPase, N-terminus; TIGRFAM: plasma-membrane calcium-translocating P-type ATPase; ATPase, P-type (transporting), HAD superfamily, subfamily IC.


ensembl_gene_id: ANME2D_01775
symbol: lysS
gene_biotype: protein_coding
description:
  PFAM: tRNA synthetases class I (K); TIGRFAM: lysyl-tRNA synthetase, archaeal and spirochete; Belongs to the class-I aminoacyl-tRNA synthetase family.


ensembl_gene_id: ANME2D_01776
symbol: KCZ71722.1
gene_biotype: protein_coding
description:
  Cytidyltransferase-related enzyme; PFAM: Cytidylyltransferase; TIGRFAM: cytidyltransferase-like domain.


ensembl_gene_id: ANME2D_01790
symbol: hmgA
gene_biotype: protein_coding
description:
  NADP-dependent hydroxymethylglutaryl-CoA reductase; PFAM: Hydroxymethylglutaryl-coenzyme A reductase; TIGRFAM: 3-hydroxy-3-methylglutaryl Coenzyme A reductase, hydroxymethylglutaryl-CoA reductase (NADP); Belongs to the HMG-CoA reductase family.


ensembl_gene_id: ANME2D_01793
symbol: ilvC
gene_biotype: protein_coding
description:
  Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.


ensembl_gene_id: ANME2D_01795
symbol: thiL
gene_biotype: protein_coding
description:
  Thiamine-phosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family.


ensembl_gene_id: ANME2D_01796
symbol: KCZ71742.1
gene_biotype: protein_coding
description:
  KH-domain/beta-lactamase-domain protein; PFAM: Metallo-beta-lactamase superfamily; RNA-metabolising metallo-beta-lactamase; Beta-Casp domain; TIGRFAM: arCOG00543 universal archaeal KH-domain/beta-lactamase-domain protein.


ensembl_gene_id: ANME2D_01797
symbol: psmB
gene_biotype: protein_coding
description:
  Proteasome endopeptidase complex, archaeal, beta subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.


ensembl_gene_id: ANME2D_01798
symbol: proS
gene_biotype: protein_coding
description:
  prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).


ensembl_gene_id: ANME2D_01803
symbol: KCZ71749.1
gene_biotype: protein_coding
description:
  Putative transcriptional regulator with CopG/Arc/MetJ DNA-binding domain and metal-binding domain; PFAM: Ribbon-helix-helix protein, copG family.


ensembl_gene_id: ANME2D_01804
symbol: thrS
gene_biotype: protein_coding
description:
  PFAM: Anticodon binding domain; tRNA synthetase class II core domain (G, H, P, S and T); Archaea-specific editing domain of threonyl-tRNA synthetase; TIGRFAM: threonyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family.


ensembl_gene_id: ANME2D_01805
symbol: KCZ71751.1
gene_biotype: protein_coding
description:
  Phosphomannomutase; PFAM: Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III; Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II; Phosphoglucomutase/phosphomannomutase, C-terminal domain; Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I; TIGRFAM: phosphoglucosamine mutase; Belongs to the phosphohexose mutase family.


ensembl_gene_id: ANME2D_01807
symbol: KCZ71753.1
gene_biotype: protein_coding
description:
  PFAM: Putative transposase DNA-binding domain; TIGRFAM: transposase, IS605 OrfB family, central region.


ensembl_gene_id: ANME2D_01809
symbol: KCZ71755.1
gene_biotype: protein_coding
description:
  Putative metal-dependent protease of the PAD1/JAB1 superfamily; PFAM: Prokaryotic homologs of the JAB domain.


ensembl_gene_id: ANME2D_01818
symbol: KCZ71763.1
gene_biotype: protein_coding
description:
  Transposase, IS605 OrfB family, central region; PFAM: Helix-turn-helix domain; Putative transposase DNA-binding domain; Probable transposase; TIGRFAM: transposase, IS605 OrfB family, central region.


ensembl_gene_id: ANME2D_01827
symbol: KCZ71772.1
gene_biotype: protein_coding
description:
  ABC-type uncharacterized transport system, ATPase component; PFAM: ABC transporter; Domain of unknown function (DUF4162).


ensembl_gene_id: ANME2D_01829
symbol: KCZ71774.1
gene_biotype: protein_coding
description:
  Putative transcriptional regulator; PFAM: Domain of unknown function (DUF1724); Winged helix DNA-binding domain.


ensembl_gene_id: ANME2D_01838
symbol: leuD
gene_biotype: protein_coding
description:
  3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily.


ensembl_gene_id: ANME2D_01840
symbol: KCZ71785.1
gene_biotype: protein_coding
description:
  PFAM: Methyltransferase domain; TIGRFAM: precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit.


ensembl_gene_id: ANME2D_01841
symbol: KCZ71786.1
gene_biotype: protein_coding
description:
  Precorrin-4 C11-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-2 C20-methyltransferase; precorrin-4 C11-methyltransferase; Belongs to the precorrin methyltransferase family.


ensembl_gene_id: ANME2D_01842
symbol: KCZ71787.1
gene_biotype: protein_coding
description:
  Cobalamin biosynthesis protein CbiG; PFAM: Cobalamin synthesis G C-terminus; Cobalamin synthesis G N-terminal.


ensembl_gene_id: ANME2D_01843
symbol: KCZ71788.1
gene_biotype: protein_coding
description:
  precorrin-3B C17-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-3B C17-methyltransferase.


ensembl_gene_id: ANME2D_01847
symbol: KCZ71792.1
gene_biotype: protein_coding
description:
  2-polyprenylphenol hydroxylase-like oxidoreductase; PFAM: Oxidoreductase FAD-binding domain; Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B; Oxidoreductase NAD-binding domain; TIGRFAM: sulfite reductase, subunit B.


ensembl_gene_id: ANME2D_01849
symbol: proB
gene_biotype: protein_coding
description:
  Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.


ensembl_gene_id: ANME2D_01850
symbol: proA
gene_biotype: protein_coding
description:
  Glutamate-5-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family.


ensembl_gene_id: ANME2D_01852
symbol: rnp-2
gene_biotype: protein_coding
description:
  RNase P subunit RPR2; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.


ensembl_gene_id: ANME2D_01859
symbol: KCZ71804.1
gene_biotype: protein_coding
description:
  Chlor Arch YYY domain; PFAM: Uncharacterized membrane protein (DUF2298); TIGRFAM: Chlor_Arch_YYY domain.


ensembl_gene_id: ANME2D_01865
symbol: KCZ71810.1
gene_biotype: protein_coding
description:
  Conserved repeat protein; PFAM: Translocon-associated protein beta (TRAPB); TIGRFAM: conserved repeat domain.


ensembl_gene_id: ANME2D_01866
symbol: KCZ71811.1
gene_biotype: protein_coding
description:
  PGF-CTERM archaeal protein-sorting signal; PFAM: von Willebrand factor type A domain; Vault protein inter-alpha-trypsin domain; TIGRFAM: PGF-CTERM archaeal protein-sorting signal.


ensembl_gene_id: ANME2D_01869
symbol: KCZ71814.1
gene_biotype: protein_coding
description:
  Uncharacterized protein involved in the oxidation of intracellular sulfur; PFAM: DsrE/DsrF-like family.


ensembl_gene_id: ANME2D_01872
symbol: moeB
gene_biotype: protein_coding
description:
  Dinucleotide-utilizing enzyme possibly involved in molybdopterin or thiamin biosynthesis; PFAM: MoeZ/MoeB domain; ThiF family.


ensembl_gene_id: ANME2D_01880
symbol: topA
gene_biotype: protein_coding
description:
  DNA topoisomerase I, archaeal; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removin [...]


ensembl_gene_id: ANME2D_01884
symbol: KCZ71829.1
gene_biotype: protein_coding
description:
  8-amino-7-oxononanoate synthase; PFAM: Aminotransferase class I and II; TIGRFAM: 8-amino-7-oxononanoate synthase.


ensembl_gene_id: ANME2D_01887
symbol: bioB
gene_biotype: protein_coding
description:
  Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family.


ensembl_gene_id: ANME2D_01895
symbol: KCZ71840.1
gene_biotype: protein_coding
description:
  PFAM: Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E); TIGRFAM: poly(R)-hydroxyalkanoic acid synthase, class III, PhaE subunit.


ensembl_gene_id: ANME2D_01897
symbol: fabG-3
gene_biotype: protein_coding
description:
  Dehydrogenase of unknown specificity, short-chain alcohol dehydrogenase like; PFAM: short chain dehydrogenase; TIGRFAM: 3-oxoacyl-(acyl-carrier-protein) reductase.


ensembl_gene_id: ANME2D_01900
symbol: KCZ71845.1
gene_biotype: protein_coding
description:
  PFAM: Molybdopterin guanine dinucleotide synthesis protein B; MoaE protein; TIGRFAM: molybdopterin-guanine dinucleotide biosynthesis protein MobB; molybdopterin synthase subunit MoaE; molybdopterin guanine dinucleotide biosynthesis accessory protein MobB.


ensembl_gene_id: ANME2D_01901
symbol: argS
gene_biotype: protein_coding
description:
  arginyl-tRNA synthetase; PFAM: DALR anticodon binding domain; Arginyl tRNA synthetase N terminal domain; tRNA synthetases class I (R); TIGRFAM: arginyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.


ensembl_gene_id: ANME2D_01903
symbol: KCZ71848.1
gene_biotype: protein_coding
description:
  Ribonucleoside-triphosphate reductase class III catalytic subunit; PFAM: Anaerobic ribonucleoside-triphosphate reductase; TIGRFAM: anaerobic ribonucleoside-triphosphate reductase.


ensembl_gene_id: ANME2D_01923
symbol: tpsp
gene_biotype: protein_coding
description:
  PFAM: Trehalose-phosphatase; Glycosyltransferase family 20; TIGRFAM: trehalose-phosphatase; alpha,alpha-trehalose-phosphate synthase [UDP-forming]; HAD-superfamily hydrolase, subfamily IIB.


ensembl_gene_id: ANME2D_01928
symbol: KCZ71873.1
gene_biotype: protein_coding
description:
  PAS domain S-box; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; GAF domain; His Kinase A (phospho-acceptor) domain; PAS fold; TIGRFAM: PAS domain S-box.


ensembl_gene_id: ANME2D_01931
symbol: KCZ71876.1
gene_biotype: protein_coding
description:
  PAS/PAC sensor hybrid histidine kinase; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Response regulator receiver domain; His Kinase A (phospho-acceptor) domain; PAS domain; TIGRFAM: PAS domain S-box.


ensembl_gene_id: ANME2D_01942
symbol: KCZ71886.1
gene_biotype: protein_coding
description:
  CO dehydrogenase/acetyl-CoA synthase gamma subunit (corrinoid Fe-S protein); PFAM: Putative Fe-S cluster; 4Fe-4S binding domain.


ensembl_gene_id: ANME2D_01943
symbol: trpG
gene_biotype: protein_coding
description:
  Anthranilate synthase, component II; PFAM: Glutamine amidotransferase class-I; TIGRFAM: glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase.


ensembl_gene_id: ANME2D_01944
symbol: trpE
gene_biotype: protein_coding
description:
  Anthranilate synthase, component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concent [...]


ensembl_gene_id: ANME2D_01946
symbol: trpD
gene_biotype: protein_coding
description:
  Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA).


ensembl_gene_id: ANME2D_01948
symbol: rpl7ae
gene_biotype: protein_coding
description:
  LSU ribosomal protein L7AE; Multifunctional RNA-binding protein that recognizes the K- turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.


ensembl_gene_id: ANME2D_01951
symbol: ndk
gene_biotype: protein_coding
description:
  Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.


ensembl_gene_id: ANME2D_01953
symbol: KCZ71897.1
gene_biotype: protein_coding
description:
  Arginase family hydrolase, arginase/agmainase/formiminoglutamate hydrolase; PFAM: Arginase family; TIGRFAM: formimidoylglutamase.


ensembl_gene_id: ANME2D_01956
symbol: KCZ71900.1
gene_biotype: protein_coding
description:
  PFAM: Acyl-CoA dehydrogenase, C-terminal domain; Acyl-CoA dehydrogenase, middle domain; Acyl-CoA dehydrogenase, N-terminal domain.


ensembl_gene_id: ANME2D_01961
symbol: infB
gene_biotype: protein_coding
description:
  Translation initiation factor aIF-2/yIF-2; Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.


ensembl_gene_id: ANME2D_01964
symbol: KCZ71908.1
gene_biotype: protein_coding
description:
  Copper/silver-translocating P-type ATPase; PFAM: YHS domain; E1-E2 ATPase; Cupredoxin-like domain; haloacid dehalogenase-like hydrolase; TIGRFAM: copper-(or silver)-translocating P-type ATPase; heavy metal translocating P-type ATPase; ATPase, P-type (transporting), HAD superfamily, subfamily IC.


ensembl_gene_id: ANME2D_01965
symbol: KCZ71909.1
gene_biotype: protein_coding
description:
  Glutaredoxin-like protein; PFAM: Thioredoxin domain; TIGRFAM: small redox-active disulfide protein 1.


ensembl_gene_id: ANME2D_01973
symbol: KCZ71917.1
gene_biotype: protein_coding
description:
  AAA family ATPase, CDC48 subfamily; PFAM: ATPase family associated with various cellular activities (AAA); Cell division protein 48 (CDC48), N-terminal domain; Cell division protein 48 (CDC48), domain 2; TIGRFAM: AAA family ATPase, CDC48 subfamily.


ensembl_gene_id: ANME2D_01976
symbol: KCZ71920.1
gene_biotype: protein_coding
description:
  Putative phosphoribosyltransferase; PFAM: Phosphoribosyl transferase domain; Alpha/beta hydrolase family.


ensembl_gene_id: ANME2D_02008
symbol: KCZ71951.1
gene_biotype: protein_coding
description:
  RecJ-like exonuclease with DnaJ-type Zn-finger domain; PFAM: DHH family; S1 RNA binding domain; OB-fold nucleic acid binding domain.


ensembl_gene_id: ANME2D_02012
symbol: KCZ71955.1
gene_biotype: protein_coding
description:
  Putative transcriptional regulator; PFAM: Domain of unknown function (DUF1724); Helix-turn-helix domain.


ensembl_gene_id: ANME2D_02021
symbol: KCZ71964.1
gene_biotype: protein_coding
description:
  PFAM: Eukaryotic and archaeal DNA primase small subunit; TIGRFAM: DNA primase, eukaryotic-type, small subunit, putative.


ensembl_gene_id: ANME2D_02022
symbol: KCZ71965.1
gene_biotype: protein_coding
description:
  PFAM: HhH-GPD superfamily base excision DNA repair protein; 8-oxoguanine DNA glycosylase, N-terminal domain; TIGRFAM: 8-oxoguanine DNA-glycosylase (ogg).


ensembl_gene_id: ANME2D_02030
symbol: KCZ71973.1
gene_biotype: protein_coding
description:
  Histone acetyltransferase, ELP3 family; PFAM: Acetyltransferase (GNAT) family; Radical SAM superfamily; TIGRFAM: histone acetyltransferase, ELP3 family.


ensembl_gene_id: ANME2D_02039
symbol: KCZ71313.1
gene_biotype: protein_coding
description:
  LPPG:FO 2-phospho-L-lactate transferase; PFAM: Uncharacterised protein family UPF0052; TIGRFAM: LPPG:FO 2-phospho-L-lactate transferase.


ensembl_gene_id: ANME2D_02044
symbol: KCZ71317.1
gene_biotype: protein_coding
description:
  Isoprenylcysteine carboxyl methyltransferase (ICMT) family protein; PFAM: Phospholipid methyltransferase.


ensembl_gene_id: ANME2D_02066
symbol: atpD
gene_biotype: protein_coding
description:
  H(+)-transporting ATP synthase, vacuolar type, subunit D; Produces ATP from ADP in the presence of a proton gradient across the membrane.


ensembl_gene_id: ANME2D_02067
symbol: atpB
gene_biotype: protein_coding
description:
  ATP synthase, B subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.


ensembl_gene_id: ANME2D_02068
symbol: atpA
gene_biotype: protein_coding
description:
  ATP synthase, A subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit. Belongs to the ATPase alpha/beta chains family.


ensembl_gene_id: ANME2D_02069
symbol: atpF
gene_biotype: protein_coding
description:
  Archaeal/vacuolar-type H+-ATPase subunit F; Produces ATP from ADP in the presence of a proton gradient across the membrane.


ensembl_gene_id: ANME2D_02070
symbol: atpC
gene_biotype: protein_coding
description:
  ATP synthase A1, C subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane.


ensembl_gene_id: ANME2D_02071
symbol: atpE
gene_biotype: protein_coding
description:
  Archaeal/vacuolar-type H+-ATPase subunit E; Produces ATP from ADP in the presence of a proton gradient across the membrane.


ensembl_gene_id: ANME2D_02075
symbol: KCZ71348.1
gene_biotype: protein_coding
description:
  Ribose-1,5-bisphosphate isomerase, e2b2 family; PFAM: Initiation factor 2 subunit family; TIGRFAM: eIF-2B alpha/beta/delta-related uncharacterized proteins; ribose-1,5-bisphosphate isomerase, e2b2 family; Belongs to the eIF-2B alpha/beta/delta subunits family.


ensembl_gene_id: ANME2D_02076
symbol: cobQ
gene_biotype: protein_coding
description:
  Adenosylcobyric acid synthase (glutamine-hydrolysing); Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily.


ensembl_gene_id: ANME2D_02078
symbol: KCZ71351.1
gene_biotype: protein_coding
description:
  Orotate phosphoribosyltransferase-like enzyme; PFAM: Phosphoribosyl transferase domain; Belongs to the purine/pyrimidine phosphoribosyltransferase family.


ensembl_gene_id: ANME2D_02079
symbol: trmY-2
gene_biotype: protein_coding
description:
  Hypothetical protein; Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs; Belongs to the methyltransferase superfamily. TrmY family.


ensembl_gene_id: ANME2D_02083
symbol: tfb
gene_biotype: protein_coding
description:
  Transcription initiation factor TFIIIB, Brf1 subunit/transcription initiation factor TFIIB; Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).


ensembl_gene_id: ANME2D_02086
symbol: srp
gene_biotype: protein_coding
description:
  Signal recognition particle 19 kDa protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.


ensembl_gene_id: ANME2D_02088
symbol: KCZ71361.1
gene_biotype: protein_coding
description:
  Phosphate transport regulator related to PhoU; PFAM: Protein of unknown function DUF47; TIGRFAM: TIGR00153 family protein.


ensembl_gene_id: ANME2D_02090
symbol: pstB-2
gene_biotype: protein_coding
description:
  Phosphate ABC transporter ATP-binding protein, PhoT family; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.


ensembl_gene_id: ANME2D_02091
symbol: KCZ71364.1
gene_biotype: protein_coding
description:
  Phosphate ABC transporter, permease protein PstA; PFAM: Binding-protein-dependent transport system inner membrane component; TIGRFAM: phosphate ABC transporter, permease protein PstA.


ensembl_gene_id: ANME2D_02092
symbol: KCZ71365.1
gene_biotype: protein_coding
description:
  Phosphate ABC transporter membrane protein 1, PhoT family; Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.


ensembl_gene_id: ANME2D_02105
symbol: KCZ71378.1
gene_biotype: protein_coding
description:
  Hypothetical protein; PFAM: Domain of unknown function (DUF4440); TIGRFAM: conserved hypothetical protein.


ensembl_gene_id: ANME2D_02113
symbol: KCZ71385.1
gene_biotype: protein_coding
description:
  PFAM: PEP-utilising enzyme, mobile domain; Pyruvate phosphate dikinase, PEP/pyruvate binding domain.


ensembl_gene_id: ANME2D_02129
symbol: gltB
gene_biotype: protein_coding
description:
  Glutamate synthase family protein; PFAM: 4Fe-4S dicluster domain; Conserved region in glutamate synthase; Belongs to the glutamate synthase family.


ensembl_gene_id: ANME2D_02131
symbol: KCZ71402.1
gene_biotype: protein_coding
description:
  Heterodisulfide reductase, subunit B; PFAM: Cysteine-rich domain; 4Fe-4S dicluster domain; TIGRFAM: CoB--CoM heterodisulfide reductase, subunit B.


ensembl_gene_id: ANME2D_02135
symbol: cobB
gene_biotype: protein_coding
description:
  Hydrogenobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP- dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source.


ensembl_gene_id: ANME2D_02145
symbol: KCZ71415.1
gene_biotype: protein_coding
description:
  PFAM: Conserved region in glutamate synthase; Protein of unknown function (DUF2769); Belongs to the glutamate synthase family.


ensembl_gene_id: ANME2D_02151
symbol: KCZ71421.1
gene_biotype: protein_coding
description:
  Segregation and condensation protein B; PFAM: Putative transcriptional regulators (Ypuh-like); TIGRFAM: segregation and condensation protein B.


ensembl_gene_id: ANME2D_02158
symbol: C1-3
gene_biotype: protein_coding
description:
  Pyridine nucleotide-disulfide oxidoreductase; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).


ensembl_gene_id: ANME2D_02164
symbol: fdhA
gene_biotype: protein_coding
description:
  NADH:ubiquinone oxidoreductase chain G-like protein; PFAM: Molybdopterin oxidoreductase Fe4S4 domain.


ensembl_gene_id: ANME2D_02167
symbol: nadA
gene_biotype: protein_coding
description:
  Quinolinate synthetase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.


ensembl_gene_id: ANME2D_02173
symbol: KCZ71443.1
gene_biotype: protein_coding
description:
  Bacteriophytochrome (light-regulated signal transduction histidine kinase); PFAM: Response regulator receiver domain; His Kinase A (phospho-acceptor) domain.


ensembl_gene_id: ANME2D_02176
symbol: KCZ71446.1
gene_biotype: protein_coding
description:
  PAS domain S-box; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; GAF domain; Response regulator receiver domain; His Kinase A (phospho-acceptor) domain; PAS fold; TIGRFAM: PAS domain S-box.


ensembl_gene_id: ANME2D_02181
symbol: KCZ71451.1
gene_biotype: protein_coding
description:
  PAS domain S-box; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Response regulator receiver domain; His Kinase A (phospho-acceptor) domain; PAS domain; PAS fold; TIGRFAM: PAS domain S-box.


ensembl_gene_id: ANME2D_02182
symbol: KCZ71452.1
gene_biotype: protein_coding
description:
  Bacteriophytochrome (light-regulated signal transduction histidine kinase); PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phospho-acceptor) domain.


ensembl_gene_id: ANME2D_02186
symbol: KCZ71456.1
gene_biotype: protein_coding
description:
  Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor); PFAM: STAS domain; TIGRFAM: anti-anti-sigma factor.


ensembl_gene_id: ANME2D_02188
symbol: KCZ71458.1
gene_biotype: protein_coding
description:
  Anti-sigma regulatory factor (Ser/Thr protein kinase); PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase.


ensembl_gene_id: ANME2D_02193
symbol: KCZ71463.1
gene_biotype: protein_coding
description:
  Ribose-phosphate pyrophosphokinase; PFAM: Phosphoribosyl transferase domain; N-terminal domain of ribose phosphate pyrophosphokinase; TIGRFAM: ribose-phosphate pyrophosphokinase.


ensembl_gene_id: ANME2D_02195
symbol: KCZ71465.1
gene_biotype: protein_coding
description:
  Poly(3-hydroxyalkanoate) synthetase; PFAM: Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; alpha/beta hydrolase fold; TIGRFAM: poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit.


ensembl_gene_id: ANME2D_02199
symbol: KCZ71469.1
gene_biotype: protein_coding
description:
  PFAM: Radical SAM superfamily; B12 binding domain; TIGRFAM: B12-binding domain/radical SAM domain protein, MJ_1487 family.


ensembl_gene_id: ANME2D_02203
symbol: KCZ71473.1
gene_biotype: protein_coding
description:
  Putative ATPase involved in replication control, Cdc46/Mcm family; PFAM: MCM N-terminal domain; MCM2/3/5 family.


ensembl_gene_id: ANME2D_02207
symbol: ilvE
gene_biotype: protein_coding
description:
  Branched-chain amino acid aminotransferase, group I; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.


ensembl_gene_id: ANME2D_02209
symbol: ribB
gene_biotype: protein_coding
description:
  3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.


ensembl_gene_id: ANME2D_02210
symbol: ribK
gene_biotype: protein_coding
description:
  Transcriptional regulator of a riboflavin/FAD biosynthetic operon; PFAM: Domain of unknown function DUF120.


ensembl_gene_id: ANME2D_02217
symbol: guaAA
gene_biotype: protein_coding
description:
  GMP synthase, glutamine-hydrolyzing, N-terminal domain or A subunit; Catalyzes the synthesis of GMP from XMP.


ensembl_gene_id: ANME2D_02220
symbol: KCZ71489.1
gene_biotype: protein_coding
description:
  Superfamily II helicase; PFAM: Protein of unknown function DUF91; Helicase conserved C-terminal domain; Sec63 Brl domain; DEAD/DEAH box helicase.


ensembl_gene_id: ANME2D_02222
symbol: KCZ71491.1
gene_biotype: protein_coding
description:
  PFAM: ATPase family associated with various cellular activities (AAA); Belongs to the AAA ATPase family.


ensembl_gene_id: ANME2D_02224
symbol: porC
gene_biotype: protein_coding
description:
  PFAM: Pyruvate ferredoxin/flavodoxin oxidoreductase; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate family.


ensembl_gene_id: ANME2D_02225
symbol: porD
gene_biotype: protein_coding
description:
  PFAM: 4Fe-4S dicluster domain; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate family.


ensembl_gene_id: ANME2D_02240
symbol: KCZ71509.1
gene_biotype: protein_coding
description:
  Protein of unknown function (DUF1905); PFAM: Bacteriocin-protection, YdeI or OmpD-Associated; Domain of unknown function (DUF1905).


ensembl_gene_id: ANME2D_02247
symbol: pqqE
gene_biotype: protein_coding
description:
  PFAM: Radical SAM superfamily; 4Fe-4S single cluster domain; TIGRFAM: putative heme d1 biosynthesis radical SAM protein NirJ1; radical SAM additional 4Fe4S-binding SPASM domain.


ensembl_gene_id: ANME2D_02249
symbol: KCZ71517.1
gene_biotype: protein_coding
description:
  Putative GTPase; PFAM: Nucleolar GTP-binding protein 1 (NOG1); TIGRFAM: small GTP-binding protein domain.


ensembl_gene_id: ANME2D_02253
symbol: rimK
gene_biotype: protein_coding
description:
  Glutathione synthase/ribosomal protein S6 modification enzyme (glutaminyl transferase); PFAM: RimK-like ATP-grasp domain.


ensembl_gene_id: ANME2D_02256
symbol: hisA
gene_biotype: protein_coding
description:
  1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; PFAM: Histidine biosynthesis protein; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.


ensembl_gene_id: ANME2D_02257
symbol: KCZ71524.1
gene_biotype: protein_coding
description:
  PFAM: Cytidylyltransferase; TIGRFAM: nicotinamide-nucleotide adenylyltransferase; cytidyltransferase-like domain.


ensembl_gene_id: ANME2D_02259
symbol: mer
gene_biotype: protein_coding
description:
  5,10-methylenetetrahydromethanopterin reductase; Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT; Belongs to the mer family.


ensembl_gene_id: ANME2D_02268
symbol: KCZ71535.1
gene_biotype: protein_coding
description:
  Thioredoxin domain-containing protein; PFAM: Protein of unknown function, DUF255; highly conserved protein containing a thioredoxin domain.


ensembl_gene_id: ANME2D_02272
symbol: KCZ71539.1
gene_biotype: protein_coding
description:
  Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase component; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain.


ensembl_gene_id: ANME2D_02279
symbol: sdhA
gene_biotype: protein_coding
description:
  PFAM: FAD binding domain; Fumarate reductase flavoprotein C-term; TIGRFAM: succinate dehydrogenase, flavoprotein subunit, E. coli/mitochondrial subgroup; succinate dehydrogenase or fumarate reductase, flavoprotein subunitGram-negative/mitochondrial subgroup.


ensembl_gene_id: ANME2D_02283
symbol: KCZ71550.1
gene_biotype: protein_coding
description:
  Thiamine pyrophosphate-dependent enzyme, possible carboligase or decarboxylase; PFAM: Thiamine pyrophosphate enzyme, central domain; Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; Belongs to the TPP enzyme family.


ensembl_gene_id: ANME2D_02285
symbol: acnA
gene_biotype: protein_coding
description:
  PFAM: Aconitase C-terminal domain; Aconitase family (aconitate hydratase); TIGRFAM: aconitate hydratase 1.


ensembl_gene_id: ANME2D_02292
symbol: mqnD
gene_biotype: protein_coding
description:
  Putative periplasmic solute-binding protein; Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2); Belongs to the MqnA/MqnD family. MqnD subfamily.


ensembl_gene_id: ANME2D_02293
symbol: KCZ71558.1
gene_biotype: protein_coding
description:
  Futalosine hydrolase; PFAM: Phosphorylase superfamily; TIGRFAM: futalosine nucleosidase; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase.


ensembl_gene_id: ANME2D_02296
symbol: KCZ71561.1
gene_biotype: protein_coding
description:
  PFAM: Radical SAM superfamily; 4Fe-4S single cluster domain; TIGRFAM: anaerobic ribonucleoside-triphosphate reductase activating protein.


ensembl_gene_id: ANME2D_02298
symbol: KCZ71563.1
gene_biotype: protein_coding
description:
  Methionine aminopeptidase, type II; PFAM: Metallopeptidase family M24; TIGRFAM: methionine aminopeptidase, type II.


ensembl_gene_id: ANME2D_02299
symbol: KCZ71564.1
gene_biotype: protein_coding
description:
  Radical SAM protein, TatD family-associated; PFAM: Radical SAM superfamily; 4Fe-4S single cluster domain; TIGRFAM: radical SAM protein, TatD family-associated.


ensembl_gene_id: ANME2D_02307
symbol: KCZ71572.1
gene_biotype: protein_coding
description:
  NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit; PFAM: NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; 4Fe-4S binding domain; Respiratory-chain NADH dehydrogenase 51 Kd subunit; Thioredoxin-like [2Fe-2S] ferredoxin; SLBB domain.


ensembl_gene_id: ANME2D_02311
symbol: acnB
gene_biotype: protein_coding
description:
  PFAM: Aconitate B N-terminal domain; Aconitase family (aconitate hydratase); Aconitate hydratase 2 N-terminus; TIGRFAM: aconitate hydratase 2.


ensembl_gene_id: ANME2D_02341
symbol: KCZ71606.1
gene_biotype: protein_coding
description:
  PFAM: Phage Mu protein F like protein; TIGRFAM: phage putative head morphogenesis protein, SPP1 gp7 family.


ensembl_gene_id: ANME2D_02344
symbol: KCZ71609.1
gene_biotype: protein_coding
description:
  PFAM: Terminase-like family; TIGRFAM: phage uncharacterized protein (putative large terminase), C-terminal domain.


ensembl_gene_id: ANME2D_02374
symbol: KCZ71639.1
gene_biotype: protein_coding
description:
  PFAM: Protein of unknown function (DUF1016); Type I restriction modification DNA specificity domain.


ensembl_gene_id: ANME2D_02377
symbol: KCZ71642.1
gene_biotype: protein_coding
description:
  Pyridoxal phosphate synthase yaaE subunit; PFAM: SNO glutamine amidotransferase family; TIGRFAM: pyridoxal 5'-phosphate synthase, glutaminase subunit Pdx2.


ensembl_gene_id: ANME2D_02380
symbol: nifH-2
gene_biotype: protein_coding
description:
  Nitrogenase subunit NifH (ATPase); PFAM: 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family; TIGRFAM: nitrogenase iron protein.


ensembl_gene_id: ANME2D_02381
symbol: KCZ71646.1
gene_biotype: protein_coding
description:
  PFAM: Nitrogenase component 1 type Oxidoreductase; TIGRFAM: putative methanogenesis marker 13 metalloprotein.


ensembl_gene_id: ANME2D_02390
symbol: KCZ71654.1
gene_biotype: protein_coding
description:
  PFAM: 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; TIGRFAM: menaquinone biosynthesis decarboxylase, SCO4490 family; UbiD family decarboxylase.


ensembl_gene_id: ANME2D_02395
symbol: KCZ71659.1
gene_biotype: protein_coding
description:
  Isoleucine patch superfamily enzyme, carbonic anhydrase/acetyltransferase; PFAM: Hexapeptide repeat of succinyl-transferase; Bacterial transferase hexapeptide (six repeats).


ensembl_gene_id: ANME2D_02407
symbol: KCZ71671.1
gene_biotype: protein_coding
description:
  Beta-propeller domain-containing protein, methanol dehydrogenase; PFAM: TLP18.3, Psb32 and MOLO-1 founding proteins of phosphatase.


ensembl_gene_id: ANME2D_02408
symbol: KCZ71672.1
gene_biotype: protein_coding
description:
  PFAM: Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus.


ensembl_gene_id: ANME2D_02412
symbol: KCZ71676.1
gene_biotype: protein_coding
description:
  Multisubunit Na+/H+ antiporter, MnhF subunit; PFAM: Multiple resistance and pH regulation protein F (MrpF / PhaF).


ensembl_gene_id: ANME2D_02413
symbol: KCZ71677.1
gene_biotype: protein_coding
description:
  Multisubunit sodium/proton antiporter, MrpG subunit; PFAM: Na+/H+ antiporter subunit; TIGRFAM: monovalent cation/proton antiporter, MnhG/PhaG subunit.


ensembl_gene_id: ANME2D_02417
symbol: KCZ71681.1
gene_biotype: protein_coding
description:
  Multisubunit Na+/H+ antiporter, MnhC subunit; PFAM: NADH-ubiquinone/plastoquinone oxidoreductase chain 4L.


ensembl_gene_id: ANME2D_02418
symbol: KCZ71682.1
gene_biotype: protein_coding
description:
  Formate hydrogenlyase subunit 3/multisubunit Na+/H+ antiporter, MnhD subunit; PFAM: NADH-Ubiquinone/plastoquinone (complex I), various chains; TIGRFAM: proton-translocating NADH-quinone oxidoreductase, chain N.


ensembl_gene_id: ANME2D_02419
symbol: KCZ71683.1
gene_biotype: protein_coding
description:
  NADH:ubiquinone oxidoreductase subunit 5 (chain L)/multisubunit Na+/H+ antiporter, MnhA subunit; PFAM: NADH-Ubiquinone/plastoquinone (complex I), various chains.


ensembl_gene_id: ANME2D_02421
symbol: KCZ71685.1
gene_biotype: protein_coding
description:
  Formate hydrogenlyase subunit 3/multisubunit Na+/H+ antiporter, MnhD subunit; PFAM: NADH-Ubiquinone/plastoquinone (complex I), various chains.


ensembl_gene_id: ANME2D_02423
symbol: rpoD
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerase, alpha subunit/40 kD subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.


ensembl_gene_id: ANME2D_02424
symbol: rps-9
gene_biotype: protein_coding
description:
  Archaeal ribosomal protein S11P; Located on the platform of the 30S subunit. Belongs to the universal ribosomal protein uS11 family.


ensembl_gene_id: ANME2D_02425
symbol: rps-10
gene_biotype: protein_coding
description:
  Ribosomal protein S4/S9; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.


ensembl_gene_id: ANME2D_02426
symbol: rps-11
gene_biotype: protein_coding
description:
  Archaeal ribosomal protein S13P; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement; Belongs to the universal ribosomal protein uS13 family.


ensembl_gene_id: ANME2D_02452
symbol: KCZ71251.1
gene_biotype: protein_coding
description:
  PFAM: Radical SAM superfamily; 4Fe-4S single cluster domain; TIGRFAM: putative peptide-modifying radical SAM enzyme, AF0577 family; radical SAM additional 4Fe4S-binding SPASM domain.


ensembl_gene_id: ANME2D_02461
symbol: KCZ71310.1
gene_biotype: protein_coding
description:
  Micrococcal nuclease-like nuclease; PFAM: Staphylococcal nuclease homologue; coding region disrupted by sequencing gap.


ensembl_gene_id: ANME2D_02477
symbol: KCZ71275.1
gene_biotype: protein_coding
description:
  Mg-chelatase subunit ChlD; PFAM: Domain of unknown function (DUF1973); von Willebrand factor type A domain; Bacterial Ig-like domain (group 1).


ensembl_gene_id: ANME2D_02485
symbol: KCZ71283.1
gene_biotype: protein_coding
description:
  Thiamine monophosphate kinase; PFAM: AIR synthase related protein, N-terminal domain; AIR synthase related protein, C-terminal domain; TIGRFAM: thiamine-monophosphate kinase.


ensembl_gene_id: ANME2D_02514
symbol: copA
gene_biotype: protein_coding
description:
  PFAM: E1-E2 ATPase; Heavy-metal-associated domain; haloacid dehalogenase-like hydrolase; TIGRFAM: copper ion binding protein; heavy metal translocating P-type ATPase; ATPase, P-type (transporting), HAD superfamily, subfamily IC.


ensembl_gene_id: ANME2D_02518
symbol: KCZ70498.1
gene_biotype: protein_coding
description:
  PFAM: 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain.


ensembl_gene_id: ANME2D_02535
symbol: KCZ70515.1
gene_biotype: protein_coding
description:
  dTDP-glucose 4,6-dehydratase; PFAM: NAD dependent epimerase/dehydratase family; TIGRFAM: dTDP-glucose 4,6-dehydratase.


ensembl_gene_id: ANME2D_02536
symbol: KCZ70516.1
gene_biotype: protein_coding
description:
  dTDP-4-dehydrorhamnose reductase; PFAM: RmlD substrate binding domain; TIGRFAM: dTDP-4-dehydrorhamnose reductase.


ensembl_gene_id: ANME2D_02538
symbol: KCZ70518.1
gene_biotype: protein_coding
description:
  Putative permease; PFAM: ABC-2 type transporter; ABC-type polysaccharide/polyol phosphate export systems, permease component.


ensembl_gene_id: ANME2D_02539
symbol: KCZ70519.1
gene_biotype: protein_coding
description:
  ABC-type polysaccharide/polyol phosphate transport system, ATPase component; PFAM: ABC transporter; Wzt C-terminal domain.


ensembl_gene_id: ANME2D_02544
symbol: KCZ70524.1
gene_biotype: protein_coding
description:
  Hypothetical protein; PFAM: Glycosyl transferase family 2; Uncharacterised protein family (UPF0104); TIGRFAM: conserved hypothetical protein.


ensembl_gene_id: ANME2D_02553
symbol: hdrA-3
gene_biotype: protein_coding
description:
  Polyferredoxin, heterodixulfide reductase subunit A; PFAM: Methyl-viologen-reducing hydrogenase, delta subunit; Pyridine nucleotide-disulphide oxidoreductase; 4Fe-4S dicluster domain.


ensembl_gene_id: ANME2D_02573
symbol: KCZ70553.1
gene_biotype: protein_coding
description:
  PFAM: T4-like virus tail tube protein gp19; TIGRFAM: conserved hypothetical phage tail region protein.


ensembl_gene_id: ANME2D_02589
symbol: pdaD
gene_biotype: protein_coding
description:
  PFAM: Pyruvoyl-dependent arginine decarboxylase (PvlArgDC); TIGRFAM: arginine decarboxylase, pyruvoyl-dependent; Belongs to the PdaD family.


ensembl_gene_id: ANME2D_02594
symbol: purF
gene_biotype: protein_coding
description:
  Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.


ensembl_gene_id: ANME2D_02596
symbol: KCZ70575.1
gene_biotype: protein_coding
description:
  PUA-domain protein; PFAM: PUA domain; TIGRFAM: arCOG04150 universal archaeal PUA-domain protein; uncharacterized domain 2.


ensembl_gene_id: ANME2D_02600
symbol: alaS
gene_biotype: protein_coding
description:
  alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.


ensembl_gene_id: ANME2D_02610
symbol: KCZ70589.1
gene_biotype: protein_coding
description:
  Putative transcriptional regulator with HTH domain; PFAM: ATP-dependent DNA helicase recG C-terminal; HsdM N-terminal domain.


ensembl_gene_id: ANME2D_02615
symbol: mutS
gene_biotype: protein_coding
description:
  Mismatch repair ATPase (MutS family); Has ATPase and non-specific DNA-binding activities. Belongs to the DNA mismatch repair MutS family. Archaeal Muts2 subfamily.


ensembl_gene_id: ANME2D_02621
symbol: KCZ70600.1
gene_biotype: protein_coding
description:
  PFAM: Type I restriction enzyme R protein N terminus (HSDR_N); Type I restriction and modification enzyme - subunit R C terminal; Type III restriction enzyme, res subunit; TIGRFAM: type I site-specific deoxyribonuclease, HsdR family.


ensembl_gene_id: ANME2D_02628
symbol: carB
gene_biotype: protein_coding
description:
  PFAM: Carbamoyl-phosphate synthase L chain, ATP binding domain; MGS-like domain; Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Carbamoyl-phosphate synthase L chain, N-terminal domain; TIGRFAM: carbamoyl-phosphate synthase, large subunit; Belongs to the CarB family.


ensembl_gene_id: ANME2D_02630
symbol: KCZ70609.1
gene_biotype: protein_coding
description:
  Putative heme d1 biosynthesis radical SAM protein NirJ2; PFAM: Iron-sulfur cluster-binding domain; Radical SAM superfamily; 4Fe-4S single cluster domain; TIGRFAM: putative heme d1 biosynthesis radical SAM protein NirJ2; radical SAM additional 4Fe4S-binding SPASM domain; radical SAM protein, BA_1875 family.


ensembl_gene_id: ANME2D_02646
symbol: tuf
gene_biotype: protein_coding
description:
  Sulfate adenylyltransferase, large subunit; PFAM: Elongation factor Tu C-terminal domain; Elongation factor Tu domain 2; Elongation factor Tu GTP binding domain; TIGRFAM: sulfate adenylyltransferase, large subunit.


ensembl_gene_id: ANME2D_02647
symbol: cysD
gene_biotype: protein_coding
description:
  PAPS reductase/FAD synthetase family protein; PFAM: Phosphoadenosine phosphosulfate reductase family; TIGRFAM: sulfate adenylyltransferase, small subunit.


ensembl_gene_id: ANME2D_02649
symbol: KCZ70628.1
gene_biotype: protein_coding
description:
  Formate-dependent nitrite reductase, periplasmic cytochrome c552 subunit; PFAM: Cytochrome c554 and c-prime; Cytochrome c552.


ensembl_gene_id: ANME2D_02657
symbol: radA
gene_biotype: protein_coding
description:
  DNA repair and recombination protein RadA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.


ensembl_gene_id: ANME2D_02658
symbol: KCZ70637.1
gene_biotype: protein_coding
description:
  Sucrose-phosphate phosphatase-like hydrolase, Archaeal; PFAM: haloacid dehalogenase-like hydrolase; TIGRFAM: phosphoglycolate phosphatase, TA0175-type; sucrose-phosphate phosphatase subfamily.


ensembl_gene_id: ANME2D_02666
symbol: KCZ70644.1
gene_biotype: protein_coding
description:
  PAS domain S-box; PFAM: Response regulator receiver domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; MEDS: MEthanogen/methylotroph, DcmR Sensory domain; His Kinase A (phospho-acceptor) domain; PAS domain; PAS fold; TIGRFAM: PAS domain S-box.


ensembl_gene_id: ANME2D_02670
symbol: nac
gene_biotype: protein_coding
description:
  Nascent polypeptide associated complex NAC; Contacts the emerging nascent chain on the ribosome. Belongs to the NAC-alpha family.


ensembl_gene_id: ANME2D_02673
symbol: tfe
gene_biotype: protein_coding
description:
  Transcription initiation factor IIE, alpha subunit; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing  [...]


ensembl_gene_id: ANME2D_02675
symbol: KCZ70653.1
gene_biotype: protein_coding
description:
  tRNA ribose 2'-O-methyltransferase, aTrm56; Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs; Belongs to the aTrm56 family.


ensembl_gene_id: ANME2D_02676
symbol: KCZ70654.1
gene_biotype: protein_coding
description:
  Putative exonuclease of the beta-lactamase fold involved in RNA processing; PFAM: Beta-lactamase superfamily domain; RNA-metabolising metallo-beta-lactamase; Beta-Casp domain.


ensembl_gene_id: ANME2D_02682
symbol: KCZ70660.1
gene_biotype: protein_coding
description:
  PFAM: Uncharacterized protein conserved in archaea (DUF2114); TIGRFAM: putative methanogenesis marker protein 14.


ensembl_gene_id: ANME2D_02683
symbol: KCZ70661.1
gene_biotype: protein_coding
description:
  Transposase, IS605 OrfB family, central region; PFAM: Putative transposase DNA-binding domain; Probable transposase; TIGRFAM: transposase, IS605 OrfB family, central region.


ensembl_gene_id: ANME2D_02686
symbol: KCZ70664.1
gene_biotype: protein_coding
description:
  Putative GTPase, probable translation factor; PFAM: 50S ribosome-binding GTPase; TGS domain; GTPase of unknown function C-terminal.


ensembl_gene_id: ANME2D_02688
symbol: KCZ70666.1
gene_biotype: protein_coding
description:
  PFAM: ATP-binding region; TIGRFAM: MJ0570-related uncharacterized domain; TIGR00289 family protein; arCOG00187 universal archaeal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter, ATP-binding protein.


ensembl_gene_id: ANME2D_02691
symbol: KCZ70669.1
gene_biotype: protein_coding
description:
  Putative DNA-binding protein with PD1-like DNA-binding motif; PFAM: Domain of unknown function (DUF296).


ensembl_gene_id: ANME2D_02693
symbol: KCZ70670.1
gene_biotype: protein_coding
description:
  Preprotein translocase subunit SecD; PFAM: Protein export membrane protein; SecD/SecF GG Motif; TIGRFAM: protein-export membrane protein SecD.


ensembl_gene_id: ANME2D_02697
symbol: KCZ70674.1
gene_biotype: protein_coding
description:
  Phosphoesterase, MJ0936 family; PFAM: Calcineurin-like phosphoesterase superfamily domain; TIGRFAM: phosphoesterase, MJ0936 family.


ensembl_gene_id: ANME2D_02700
symbol: csl
gene_biotype: protein_coding
description:
  Putative RNA-binding protein (consists of S1 domain and a Zn-ribbon domain); Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.


ensembl_gene_id: ANME2D_02701
symbol: rpoL
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerase, subunit L; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoL/eukaryotic RPB11/RPC19 RNA polymerase subunit family.


ensembl_gene_id: ANME2D_02705
symbol: KCZ70682.1
gene_biotype: protein_coding
description:
  PFAM: Probable molybdopterin binding domain; MoeA N-terminal region (domain I and II); PBP superfamily domain; MoeA C-terminal region (domain IV); TIGRFAM: molybdenum cofactor synthesis domain.


ensembl_gene_id: ANME2D_02711
symbol: KCZ70688.1
gene_biotype: protein_coding
description:
  Deazaflavin-dependent nitroreductase family protein; PFAM: Domain of unknown function (DUF385); TIGRFAM: deazaflavin-dependent oxidoreductase, nitroreductase family.


ensembl_gene_id: ANME2D_02720
symbol: KCZ70697.1
gene_biotype: protein_coding
description:
  Ni,Fe-hydrogenase III large subunit; PFAM: Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Respiratory-chain NADH dehydrogenase, 49 Kd subunit.


ensembl_gene_id: ANME2D_02725
symbol: KCZ70702.1
gene_biotype: protein_coding
description:
  Uncharacterized membrane protein; PFAM: von Willebrand factor type A domain; Protein of unknown function (DUF1355).


ensembl_gene_id: ANME2D_02735
symbol: C4
gene_biotype: protein_coding
description:
  acetyl-CoA synthetase; PFAM: CoA binding domain; Acetyltransferase (GNAT) family; ATP-grasp domain; Succinyl-CoA ligase like flavodoxin domain; TIGRFAM: acetyl coenzyme A synthetase (ADP forming), alpha domain.


ensembl_gene_id: ANME2D_02745
symbol: KCZ70721.1
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerase, subunit RPC10 (contains C4-type Zn-finger); PFAM: DNA directed RNA polymerase, 7 kDa subunit.


ensembl_gene_id: ANME2D_02747
symbol: rrp
gene_biotype: protein_coding
description:
  RNase PH-related exoribonuclease; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site.


ensembl_gene_id: ANME2D_02748
symbol: rrp41p
gene_biotype: protein_coding
description:
  Archaeal exosome-like complex exonuclease 1; Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails.


ensembl_gene_id: ANME2D_02749
symbol: rrp-2
gene_biotype: protein_coding
description:
  RNA-binding protein Rrp4 (containing S1 domain and KH domain); Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.


ensembl_gene_id: ANME2D_02750
symbol: KCZ70726.1
gene_biotype: protein_coding
description:
  rRNA metabolism protein, SBDS family; PFAM: Shwachman-Bodian-Diamond syndrome (SBDS) protein; SBDS protein C-terminal domain; TIGRFAM: rRNA metabolism protein, SBDS family.


ensembl_gene_id: ANME2D_02751
symbol: psmA
gene_biotype: protein_coding
description:
  Proteasome endopeptidase complex, archaeal, alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.


ensembl_gene_id: ANME2D_02752
symbol: rnp-3
gene_biotype: protein_coding
description:
  RNase P/RNase MRP subunit POP5; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends; Belongs to the eukaryotic/archaeal RNase P protein component 2 family.


ensembl_gene_id: ANME2D_02754
symbol: KCZ70730.1
gene_biotype: protein_coding
description:
  Thermosome subunit; PFAM: TCP-1/cpn60 chaperonin family; TIGRFAM: T-complex protein 1, eta subunit; thermosome, various subunits, archaeal.


ensembl_gene_id: ANME2D_02766
symbol: KCZ70741.1
gene_biotype: protein_coding
description:
  RNA ligase, Pab1020 family; PFAM: ATP dependent DNA ligase domain; TIGRFAM: RNA ligase, Pab1020 family.


ensembl_gene_id: ANME2D_02772
symbol: hemA
gene_biotype: protein_coding
description:
  glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).


ensembl_gene_id: ANME2D_02776
symbol: KCZ70751.1
gene_biotype: protein_coding
description:
  ABC-type antimicrobial peptide transport system, permease component; PFAM: MacB-like periplasmic core domain; FtsX-like permease family.


ensembl_gene_id: ANME2D_02785
symbol: KCZ70760.1
gene_biotype: protein_coding
description:
  PFAM: Peptidase family M20/M25/M40; Peptidase dimerisation domain; TIGRFAM: acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase.


ensembl_gene_id: ANME2D_02788
symbol: rpoM
gene_biotype: protein_coding
description:
  PFAM: Transcription factor S-II (TFIIS); TIGRFAM: transcription factor S, archaeal; Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.


ensembl_gene_id: ANME2D_02789
symbol: mch
gene_biotype: protein_coding
description:
  Methenyltetrahydromethanopterin cyclohydrolase; Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+); Belongs to the MCH family.


ensembl_gene_id: ANME2D_02814
symbol: KCZ70789.1
gene_biotype: protein_coding
description:
  Putative Fe-S oxidoreductase; PFAM: Iron-sulfur cluster-binding domain; Radical SAM superfamily; 4Fe-4S single cluster domain.


ensembl_gene_id: ANME2D_02820
symbol: KCZ70795.1
gene_biotype: protein_coding
description:
  RNA ligase partner, MJ_0950 family; RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. Belongs to the HARP family.


ensembl_gene_id: ANME2D_02840
symbol: KCZ70815.1
gene_biotype: protein_coding
description:
  Hypothetical protein; PFAM: Carboxypeptidase regulatory-like domain; Domain of unknown function (DUF4480).


ensembl_gene_id: ANME2D_02852
symbol: KCZ70827.1
gene_biotype: protein_coding
description:
  TIGR00299 family protein; PFAM: Protein of unknown function DUF111; TIGRFAM: TIGR00299 family protein; Belongs to the LarC family.


ensembl_gene_id: ANME2D_02869
symbol: queA
gene_biotype: protein_coding
description:
  PFAM: Queuosine biosynthesis protein; TIGRFAM: S-adenosylmethionine:tRNA ribosyltransferase-isomerase.


ensembl_gene_id: ANME2D_02870
symbol: tgt
gene_biotype: protein_coding
description:
  tRNA-guanine transglycosylase, queuosine-34-forming; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of  [...]


ensembl_gene_id: ANME2D_02875
symbol: KCZ70850.1
gene_biotype: protein_coding
description:
  PFAM: Binding-protein-dependent transport system inner membrane component; TIGRFAM: phosphonate ABC transporter, permease protein PhnE.


ensembl_gene_id: ANME2D_02882
symbol: KCZ70857.1
gene_biotype: protein_coding
description:
  PFAM: Predicted membrane protein (DUF2318); Iron permease FTR1 family; TIGRFAM: FTR1 family protein.


ensembl_gene_id: ANME2D_02889
symbol: KCZ70864.1
gene_biotype: protein_coding
description:
  WD40 repeat-containing protein; PFAM: WD domain, G-beta repeat; TIR domain; Ras family; Domain of unknown function (DUF4365).


ensembl_gene_id: ANME2D_02892
symbol: KCZ70867.1
gene_biotype: protein_coding
description:
  DNA/RNA helicase, superfamily II; PFAM: Helicase conserved C-terminal domain; Type III restriction enzyme, res subunit.


ensembl_gene_id: ANME2D_02895
symbol: KCZ70870.1
gene_biotype: protein_coding
description:
  PFAM: Nitrite and sulphite reductase 4Fe-4S domain; Nitrite/Sulfite reductase ferredoxin-like half domain.


ensembl_gene_id: ANME2D_02897
symbol: KCZ70872.1
gene_biotype: protein_coding
description:
  Putative hydrocarbon binding protein (contains V4R domain); PFAM: Helix-turn-helix domain; V4R domain.


ensembl_gene_id: ANME2D_02911
symbol: ahcY
gene_biotype: protein_coding
description:
  Adenosylhomocysteinase; Catalyzes the hydrolysis of S-inosyl-L-homocysteine (SIH) to L-homocysteine (Hcy) and inosine. Likely functions in a S-adenosyl-L- methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. Can also catalyze the reverse reaction in vitro, i.e. the synthesis of SIH from Hcy and inosine; Belongs to the adenosylhomocysteinase family.


ensembl_gene_id: ANME2D_02912
symbol: rfcS
gene_biotype: protein_coding
description:
  DNA polymerase III, gamma/tau subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcS subfamily.


ensembl_gene_id: ANME2D_02918
symbol: KCZ70892.1
gene_biotype: protein_coding
description:
  Putative phosphoesterase, ICC; PFAM: Calcineurin-like phosphoesterase superfamily domain; TIGRFAM: putative phosphoesterase, SbcD/Mre11-related.


ensembl_gene_id: ANME2D_02920
symbol: KCZ70894.1
gene_biotype: protein_coding
description:
  PFAM: Domain of unknown function (DUF1858); TIGRFAM: hybrid cluster protein-associated redox disulfide domain.


ensembl_gene_id: ANME2D_02921
symbol: tuf-2
gene_biotype: protein_coding
description:
  Translation elongation factor 1A (EF-1A/EF-Tu); This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.


ensembl_gene_id: ANME2D_02922
symbol: rps-12
gene_biotype: protein_coding
description:
  Ribosomal protein S10/S20; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family.


ensembl_gene_id: ANME2D_02931
symbol: guaAB
gene_biotype: protein_coding
description:
  GMP synthase, glutamine-hydrolyzing, C-terminal domain or B subunit; Catalyzes the synthesis of GMP from XMP.


ensembl_gene_id: ANME2D_02932
symbol: KCZ70906.1
gene_biotype: protein_coding
description:
  Trypsin-like serine protease with C-terminal PDZ domain; PFAM: Trypsin-like peptidase domain; PDZ domain.


ensembl_gene_id: ANME2D_02933
symbol: pdhD
gene_biotype: protein_coding
description:
  Dihydrolipoamide dehydrogenase; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; TIGRFAM: dihydrolipoamide dehydrogenase.


ensembl_gene_id: ANME2D_02934
symbol: KCZ70908.1
gene_biotype: protein_coding
description:
  PFAM: 2-oxoacid dehydrogenases acyltransferase (catalytic domain); e3 binding domain; Biotin-requiring enzyme; TIGRFAM: 2-oxoglutarate dehydrogenase complex dihydrolipoamide succinyltransferase (E2 component).


ensembl_gene_id: ANME2D_02935
symbol: pdhB
gene_biotype: protein_coding
description:
  Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase component beta subunit; PFAM: Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain.


ensembl_gene_id: ANME2D_02937
symbol: KCZ70911.1
gene_biotype: protein_coding
description:
  Cystathionine beta-lyase/cystathionine gamma-synthase; PFAM: Cys/Met metabolism PLP-dependent enzyme; TIGRFAM: methionine gamma-lyase; O-succinylhomoserine sulfhydrylase.


ensembl_gene_id: ANME2D_02938
symbol: KCZ70912.1
gene_biotype: protein_coding
description:
  Putative methanogenesis marker protein 8; PFAM: Uncharacterized protein conserved in archaea (DUF2099); TIGRFAM: putative methanogenesis marker protein 8.


ensembl_gene_id: ANME2D_02945
symbol: KCZ70919.1
gene_biotype: protein_coding
description:
  Cytotoxic translational repressor of toxin-antitoxin stability system; PFAM: Plasmid stabilisation system protein; TIGRFAM: addiction module toxin component, YafQ family; addiction module toxin, RelE/StbE family.


ensembl_gene_id: ANME2D_02948
symbol: KCZ70922.1
gene_biotype: protein_coding
description:
  Methylated DNA-protein cysteine methyltransferase; PFAM: 6-O-methylguanine DNA methyltransferase, DNA binding domain; TIGRFAM: O-6-methylguanine DNA methyltransferase.


ensembl_gene_id: ANME2D_02950
symbol: eif2g
gene_biotype: protein_coding
description:
  Translation initiation factor 2 subunit gamma (aeIF-2g); eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.


ensembl_gene_id: ANME2D_02952
symbol: rpoE
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerase subunit E; PFAM: S1 RNA binding domain; SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397; TIGRFAM: DNA-directed RNA polymerase (rpoE), archaeal and eukaryotic form.


ensembl_gene_id: ANME2D_02953
symbol: spt
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerase, subunit E'; Stimulates transcription elongation; Belongs to the archaeal Spt4 family.


ensembl_gene_id: ANME2D_02954
symbol: KCZ70927.1
gene_biotype: protein_coding
description:
  Hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).


ensembl_gene_id: ANME2D_02960
symbol: mat-2
gene_biotype: protein_coding
description:
  Archaeal S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP; Belongs to the AdoMet synthase 2 family.


ensembl_gene_id: ANME2D_02985
symbol: mutS-2
gene_biotype: protein_coding
description:
  DNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.


ensembl_gene_id: ANME2D_02990
symbol: metG
gene_biotype: protein_coding
description:
  Protein containing C-terminal region/beta chain of methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.


ensembl_gene_id: ANME2D_03016
symbol: ala
gene_biotype: protein_coding
description:
  Alanine dehydrogenase, Archaeoglobus fulgidus type; Catalyzes the NAD(+)-dependent oxidative deamination of L- alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate; Belongs to the ornithine cyclodeaminase/mu-crystallin family. Archaeal alanine dehydrogenase subfamily.


ensembl_gene_id: ANME2D_03022
symbol: nth-2
gene_biotype: protein_coding
description:
  Putative endoIII-related endonuclease; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.


ensembl_gene_id: ANME2D_03024
symbol: KCZ70995.1
gene_biotype: protein_coding
description:
  Putative methanogenesis marker protein 2; PFAM: AIR synthase related protein, N-terminal domain; AIR synthase related protein, C-terminal domain; TIGRFAM: putative methanogenesis marker protein 2.


ensembl_gene_id: ANME2D_03027
symbol: htpX-2
gene_biotype: protein_coding
description:
  Zn-dependent protease with chaperone function; PFAM: Peptidase family M48; Belongs to the peptidase M48B family.


ensembl_gene_id: ANME2D_03030
symbol: groL
gene_biotype: protein_coding
description:
  PFAM: TCP-1/cpn60 chaperonin family; TIGRFAM: chaperonin GroL; Belongs to the chaperonin (HSP60) family.


ensembl_gene_id: ANME2D_03040
symbol: KCZ71011.1
gene_biotype: protein_coding
description:
  Pyruvate-formate lyase-activating enzyme; PFAM: 2Fe-2S iron-sulfur cluster binding domain; Radical SAM superfamily; 4Fe-4S single cluster domain.


ensembl_gene_id: ANME2D_03047
symbol: KCZ71018.1
gene_biotype: protein_coding
description:
  PAPS reductase/FAD synthetase family protein; PFAM: Phosphoadenosine phosphosulfate reductase family.


ensembl_gene_id: ANME2D_03049
symbol: KCZ71020.1
gene_biotype: protein_coding
description:
  Sua5/YciO/YrdC/YwlC family protein; PFAM: Telomere recombination; TIGRFAM: tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family.


ensembl_gene_id: ANME2D_03052
symbol: KCZ71023.1
gene_biotype: protein_coding
description:
  ABC-type transport system involved in multi-copper enzyme maturation, permease component; PFAM: ABC-2 family transporter protein.


ensembl_gene_id: ANME2D_03062
symbol: KCZ71032.1
gene_biotype: protein_coding
description:
  Hypothetical protein; PFAM: Winged helix-turn-helix DNA-binding; Bacterial regulatory protein, arsR family.


ensembl_gene_id: ANME2D_03064
symbol: KCZ71034.1
gene_biotype: protein_coding
description:
  PAS domain S-box; PFAM: His Kinase A (phospho-acceptor) domain; PAS fold; TIGRFAM: PAS domain S-box.


ensembl_gene_id: ANME2D_03070
symbol: KCZ71040.1
gene_biotype: protein_coding
description:
  Rhodanese-related sulfurtransferase; PFAM: Metallo-beta-lactamase superfamily; Rhodanese-like domain.


ensembl_gene_id: ANME2D_03079
symbol: KCZ71049.1
gene_biotype: protein_coding
description:
  Lon-related putative ATP-dependent protease; PFAM: Magnesium chelatase, subunit ChlI; AAA domain; Lon protease (S16) C-terminal proteolytic domain; TIGRFAM: lon-related putative ATP-dependent protease; Belongs to the peptidase S16 family.


ensembl_gene_id: ANME2D_03080
symbol: KCZ71050.1
gene_biotype: protein_coding
description:
  Zn-dependent protease; PFAM: CBS domain; Peptidase family M50; Belongs to the peptidase M50B family.


ensembl_gene_id: ANME2D_03084
symbol: KCZ71054.1
gene_biotype: protein_coding
description:
  Putative transcriptional regulator with CopG/Arc/MetJ DNA-binding domain and metal-binding domain; Transcriptional regulator; Belongs to the transcriptional regulatory CopG/NikR family.


ensembl_gene_id: ANME2D_03085
symbol: KCZ71055.1
gene_biotype: protein_coding
description:
  PFAM: Proprotein convertase P-domain; Subtilase family; regulatory P domain of subtilisin-like proprotein convertases.


ensembl_gene_id: ANME2D_03098
symbol: fae-hps
gene_biotype: protein_coding
description:
  Formaldehyde-activating enzyme; Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin; In the N-terminal section; belongs to the formaldehyde- activating enzyme family.


ensembl_gene_id: ANME2D_03104
symbol: KCZ71074.1
gene_biotype: protein_coding
description:
  PFAM: Cysteine-rich secretory protein family; Cna protein B-type domain; uncharacterized protein with SCP/PR1 domains.


ensembl_gene_id: ANME2D_03105
symbol: acs
gene_biotype: protein_coding
description:
  acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.


ensembl_gene_id: ANME2D_03110
symbol: KCZ71080.1
gene_biotype: protein_coding
description:
  Respiratory nitrite reductase specific menaquinol--cytochrome-c reductase (NrfH) precursor; PFAM: NapC/NirT cytochrome c family, N-terminal region; TIGRFAM: cytochrome c nitrate reductase, small subunit.


ensembl_gene_id: ANME2D_03122
symbol: KCZ71235.1
gene_biotype: protein_coding
description:
  Hypothetical protein; PFAM: Domain of unknown function (DUF4277); coding region disrupted by sequencing gap.


ensembl_gene_id: ANME2D_03152
symbol: pyrF
gene_biotype: protein_coding
description:
  Orotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily.


ensembl_gene_id: ANME2D_03154
symbol: dys
gene_biotype: protein_coding
description:
  Deoxyhypusine synthase; Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.


ensembl_gene_id: ANME2D_03156
symbol: cbiX
gene_biotype: protein_coding
description:
  Hypothetical protein; Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni- sirohydrochlorin.


ensembl_gene_id: ANME2D_03157
symbol: cheD
gene_biotype: protein_coding
description:
  Chemotaxis protein; Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis; Belongs to the CheD family.


ensembl_gene_id: ANME2D_03158
symbol: KCZ71126.1
gene_biotype: protein_coding
description:
  Chemotaxis protein CheC, inhibitor of MCP methylation; PFAM: Chemotaxis phosphatase CheX; CheC-like family.


ensembl_gene_id: ANME2D_03159
symbol: KCZ71127.1
gene_biotype: protein_coding
description:
  Methylase of chemotaxis methyl-accepting protein; PFAM: CheR methyltransferase, SAM binding domain; CheR methyltransferase, all-alpha domain.


ensembl_gene_id: ANME2D_03160
symbol: KCZ71128.1
gene_biotype: protein_coding
description:
  Chemotaxis protein histidine kinase-like protein; PFAM: CheW-like domain; P2 response regulator binding domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Signal transducing histidine kinase, homodimeric domain; Hpt domain.


ensembl_gene_id: ANME2D_03162
symbol: cheY
gene_biotype: protein_coding
description:
  PFAM: Response regulator receiver domain; response regulator with CheY-like receiver, AAA-type ATPase, and DNA-binding domains.


ensembl_gene_id: ANME2D_03169
symbol: KCZ71137.1
gene_biotype: protein_coding
description:
  Archaeal flagellin-like protein; PFAM: Archaebacterial flagellin; TIGRFAM: archaeal flagellin N-terminal-like domain.


ensembl_gene_id: ANME2D_03180
symbol: KCZ71148.1
gene_biotype: protein_coding
description:
  Putative archaeal flagellar protein D/E; PFAM: Flagella accessory protein C (FlaC); Archaeal flagella protein.


ensembl_gene_id: ANME2D_03181
symbol: KCZ71149.1
gene_biotype: protein_coding
description:
  Chemotaxis protein CheC, inhibitor of MCP methylation; PFAM: Chemotaxis phosphatase CheX; HEAT repeats.


ensembl_gene_id: ANME2D_03184
symbol: radB
gene_biotype: protein_coding
description:
  DNA repair and recombination protein RadB; Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange.


ensembl_gene_id: ANME2D_03187
symbol: KCZ71155.1
gene_biotype: protein_coding
description:
  Putative membrane protein; PFAM: VanZ like family; S-layer protein; Protein of unknown function (DUF1616).


ensembl_gene_id: ANME2D_03194
symbol: KCZ71162.1
gene_biotype: protein_coding
description:
  Sep-tRNA:Cys-tRNA synthase; Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L- cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)); Belongs to the SepCysS family.


ensembl_gene_id: ANME2D_03197
symbol: sudA
gene_biotype: protein_coding
description:
  NADPH-dependent glutamate synthase, homotetrameric; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; TIGRFAM: glutamate synthase (NADPH), homotetrameric.


ensembl_gene_id: ANME2D_03208
symbol: asd
gene_biotype: protein_coding
description:
  Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family.


ensembl_gene_id: ANME2D_03211
symbol: KCZ71179.1
gene_biotype: protein_coding
description:
  PAS domain S-box; PFAM: Response regulator receiver domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; GAF domain; MEDS: MEthanogen/methylotroph, DcmR Sensory domain; His Kinase A (phospho-acceptor) domain; PAS domain; PAS fold; TIGRFAM: PAS domain S-box.


ensembl_gene_id: ANME2D_03212
symbol: purQ
gene_biotype: protein_coding
description:
  PFAM: CobB/CobQ-like glutamine amidotransferase domain; TIGRFAM: phosphoribosylformylglycinamidine synthase I.


ensembl_gene_id: ANME2D_03219
symbol: trpB-2
gene_biotype: protein_coding
description:
  Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.


ensembl_gene_id: ANME2D_03220
symbol: trpA
gene_biotype: protein_coding
description:
  Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.


ensembl_gene_id: ANME2D_03223
symbol: queD
gene_biotype: protein_coding
description:
  PFAM: 6-pyruvoyl tetrahydropterin synthase; TIGRFAM: 6-pyruvoyl tetrahydropterin synthase/QueD family protein.


ensembl_gene_id: ANME2D_03232
symbol: argC
gene_biotype: protein_coding
description:
  N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.


ensembl_gene_id: ANME2D_03234
symbol: argJ
gene_biotype: protein_coding
description:
  Glutamate N-acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family.


ensembl_gene_id: ANME2D_03243
symbol: KCZ71208.1
gene_biotype: protein_coding
description:
  Putative hydrocarbon binding protein (contains V4R domain); PFAM: Bacterial regulatory protein, arsR family; V4R domain.


ensembl_gene_id: ANME2D_03244
symbol: ftsY
gene_biotype: protein_coding
description:
  Signal recognition particle-docking protein FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).


ensembl_gene_id: ANME2D_03250
symbol: fen
gene_biotype: protein_coding
description:
  Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. A [...]


ensembl_gene_id: ANME2D_03254
symbol: dtdA
gene_biotype: protein_coding
description:
  Hypothetical protein; D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.


ensembl_gene_id: ANME2D_03256
symbol: queE
gene_biotype: protein_coding
description:
  Organic radical activating enzyme; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.


ensembl_gene_id: ANME2D_03260
symbol: pcm
gene_biotype: protein_coding
description:
  protein-L-isoaspartate and D-aspartate O-methyltransferase; Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.


ensembl_gene_id: ANME2D_03263
symbol: ppsA
gene_biotype: protein_coding
description:
  Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family.


ensembl_gene_id: ANME2D_03265
symbol: KCZ71230.1
gene_biotype: protein_coding
description:
  Parallel beta-helix repeat (two copies); PFAM: Periplasmic copper-binding protein (NosD); Regulator of chromosome condensation (RCC1) repeat; TIGRFAM: parallel beta-helix repeat (two copies); IMG reference gene:2515323402_SP.


ensembl_gene_id: ANME2D_03267
symbol: pncB
gene_biotype: protein_coding
description:
  PFAM: Nicotinate phosphoribosyltransferase (NAPRTase) family; TIGRFAM: putative nicotinate phosphoribosyltransferase.


ensembl_gene_id: ANME2D_03268
symbol: leuC
gene_biotype: protein_coding
description:
  Homoaconitate hydratase family protein/3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.


ensembl_gene_id: ANME2D_03282
symbol: folD
gene_biotype: protein_coding
description:
  5,10-methylene-tetrahydrofolate dehydrogenase/methenyl tetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.


ensembl_gene_id: ANME2D_03283
symbol: glyA
gene_biotype: protein_coding
description:
  Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.


ensembl_gene_id: ANME2D_03284
symbol: purN
gene_biotype: protein_coding
description:
  PFAM: Formyl transferase; TIGRFAM: phosphoribosylglycinamide formyltransferase, formyltetrahydrofolate-dependent.


ensembl_gene_id: ANME2D_03286
symbol: rbcL
gene_biotype: protein_coding
description:
  Ribulose bisphosphate carboxylase, type III; Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase. Belongs to the RuBisCO large chain family. Type III subfamily.


ensembl_gene_id: ANME2D_03288
symbol: tiaS
gene_biotype: protein_coding
description:
  Putative DNA-binding protein containing a Zn-ribbon domain; ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.


ensembl_gene_id: ANME2D_03301
symbol: KCZ70386.1
gene_biotype: protein_coding
description:
  Uncharacterized protein, gamma-carboxymuconolactone decarboxylase subunit like protein; PFAM: Carboxymuconolactone decarboxylase family.


ensembl_gene_id: ANME2D_03311
symbol: KCZ70396.1
gene_biotype: protein_coding
description:
  PFAM: NapC/NirT cytochrome c family, N-terminal region; TIGRFAM: cytochrome c nitrate reductase, small subunit.


ensembl_gene_id: ANME2D_03315
symbol: KCZ70400.1
gene_biotype: protein_coding
description:
  HIT family hydrolase, diadenosine tetraphosphate hydrolase; PFAM: Scavenger mRNA decapping enzyme C-term binding.


ensembl_gene_id: ANME2D_03321
symbol: hacA
gene_biotype: protein_coding
description:
  3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.


ensembl_gene_id: ANME2D_03322
symbol: eno
gene_biotype: protein_coding
description:
  Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.


ensembl_gene_id: ANME2D_03324
symbol: KCZ70409.1
gene_biotype: protein_coding
description:
  ABC-type transport system involved in cytochrome c biogenesis, permease component; PFAM: CcmB protein; TIGRFAM: heme exporter protein CcmB.


ensembl_gene_id: ANME2D_03325
symbol: ccmC
gene_biotype: protein_coding
description:
  ABC-type transport system involved in cytochrome c biogenesis, permease component; PFAM: Cytochrome C assembly protein.


ensembl_gene_id: ANME2D_03326
symbol: aroA-2
gene_biotype: protein_coding
description:
  3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.


ensembl_gene_id: ANME2D_03333
symbol: pfdB
gene_biotype: protein_coding
description:
  Prefoldin, beta subunit, archaeal; Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.


ensembl_gene_id: ANME2D_03335
symbol: leuA
gene_biotype: protein_coding
description:
  Isopropylmalate/citramalate/homocitrate synthase; PFAM: LeuA allosteric (dimerisation) domain; HMGL-like; TIGRFAM: isopropylmalate/citramalate/homocitrate synthases; Belongs to the alpha-IPM synthase/homocitrate synthase family.


ensembl_gene_id: ANME2D_03338
symbol: KCZ70423.1
gene_biotype: protein_coding
description:
  Archaeoflavoprotein, MJ0208 family; PFAM: 4Fe-4S binding domain; Flavoprotein; TIGRFAM: archaeoflavoprotein, MJ0208 family.


ensembl_gene_id: ANME2D_03342
symbol: srp-2
gene_biotype: protein_coding
description:
  Signal recognition particle GTPase; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily.


ensembl_gene_id: ANME2D_03358
symbol: KCZ70443.1
gene_biotype: protein_coding
description:
  PLP-dependent enzyme, glutamate decarboxylase; PFAM: Pyridoxal-dependent decarboxylase conserved domain.


ensembl_gene_id: ANME2D_03359
symbol: KCZ70444.1
gene_biotype: protein_coding
description:
  PFAM: Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Glu/Leu/Phe/Val dehydrogenase, dimerisation domain.


ensembl_gene_id: ANME2D_03360
symbol: KCZ70445.1
gene_biotype: protein_coding
description:
  PFAM: NIF3 (NGG1p interacting factor 3); TIGRFAM: dinuclear metal center protein, YbgI/SA1388 family.


ensembl_gene_id: ANME2D_03363
symbol: pdxS
gene_biotype: protein_coding
description:
  Pyridoxal phosphate synthase yaaD subunit; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family.


ensembl_gene_id: ANME2D_03369
symbol: KCZ70454.1
gene_biotype: protein_coding
description:
  PFAM: Ferrous iron transport protein B; Ferrous iron transport protein B C terminus; Nucleoside recognition; TIGRFAM: ferrous iron transporter FeoB; small GTP-binding protein domain.


ensembl_gene_id: ANME2D_03379
symbol: KCZ70464.1
gene_biotype: protein_coding
description:
  CoA-binding domain protein; PFAM: CoA binding domain; ATP-grasp domain; Succinyl-CoA ligase like flavodoxin domain; TIGRFAM: acetyl coenzyme A synthetase (ADP forming), alpha domain.


ensembl_gene_id: ANME2D_03381
symbol: KCZ70466.1
gene_biotype: protein_coding
description:
  P-type ATPase, translocating; PFAM: E1-E2 ATPase; Cation transporting ATPase, C-terminus; haloacid dehalogenase-like hydrolase; Cation transporter/ATPase, N-terminus; TIGRFAM: ATPase, P-type (transporting), HAD superfamily, subfamily IC.


ensembl_gene_id: ANME2D_03382
symbol: KCZ70467.1
gene_biotype: protein_coding
description:
  Kef-type K+ transport system, predicted NAD-binding component; PFAM: TrkA-N domain; TrkA-C domain; Sodium/hydrogen exchanger family; TIGRFAM: transporter, monovalent cation:proton antiporter-2 (CPA2) family.


ensembl_gene_id: ANME2D_03389
symbol: purL
gene_biotype: protein_coding
description:
  Phosphoribosylformylglycinamidine synthase subunit II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...]


ensembl_gene_id: ANME2D_03392
symbol: serS
gene_biotype: protein_coding
description:
  PFAM: tRNA synthetase class II core domain (G, H, P, S and T); TIGRFAM: seryl-tRNA synthetase, Methanococcus jannaschii family.


ensembl_gene_id: ANME2D_03394
symbol: KCZ70479.1
gene_biotype: protein_coding
description:
  PFAM: Aminotransferase class-III; TIGRFAM: 4-aminobutyrate aminotransferase, prokaryotic type; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.


ensembl_gene_id: ANME2D_03396
symbol: KCZ70481.1
gene_biotype: protein_coding
description:
  Theronine dehydrogenase-like Zn-dependent dehydrogenase; PFAM: Alcohol dehydrogenase GroES-like domain; Alcohol dehydrogenase GroES-associated; Zinc-binding dehydrogenase.


ensembl_gene_id: ANME2D_03397
symbol: aroC
gene_biotype: protein_coding
description:
  Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.


ensembl_gene_id: ANME2D_03398
symbol: sepS
gene_biotype: protein_coding
description:
  O-phosphoseryl-tRNA(Cys) synthetase; Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys).


ensembl_gene_id: ANME2D_03402
symbol: KCZ70487.1
gene_biotype: protein_coding
description:
  TIGR03663 family protein; PFAM: Dolichyl-phosphate-mannose-protein mannosyltransferase; TIGRFAM: TIGR03663 family protein.


ensembl_gene_id: ANME2D_03404
symbol: KCZ70489.1
gene_biotype: protein_coding
description:
  Molybdopterin biosynthesis enzyme; PFAM: Probable molybdopterin binding domain; MoeA N-terminal region (domain I and II); MoeA C-terminal region (domain IV); TIGRFAM: molybdenum cofactor synthesis domain.


ensembl_gene_id: ANME2D_03423
symbol: spt-2
gene_biotype: protein_coding
description:
  LSU ribosomal protein L24A; Stimulates transcription elongation; Belongs to the archaeal Spt5 family.


ensembl_gene_id: ANME2D_03424
symbol: rpl-9
gene_biotype: protein_coding
description:
  Ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors; Belongs to the universal ribosomal protein uL11 family.


ensembl_gene_id: ANME2D_03427
symbol: KCZ70311.1
gene_biotype: protein_coding
description:
  Geranylgeranyl reductase family protein; Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3- diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di- O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.


ensembl_gene_id: ANME2D_03429
symbol: comDE
gene_biotype: protein_coding
description:
  Sulfopyruvate decarboxylase subunit beta; PFAM: Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: sulfopyruvate decarboxylase, beta subunit; sulfopyruvate decarboxylase, alpha subunit; sulfopyruvate decarboxylase subunit beta; sulfopyruvate decarboxylase subunit alpha.


ensembl_gene_id: ANME2D_03436
symbol: KCZ70320.1
gene_biotype: protein_coding
description:
  2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase; PFAM: Fumarylacetoacetate (FAA) hydrolase family.


ensembl_gene_id: ANME2D_03442
symbol: iscS-2
gene_biotype: protein_coding
description:
  Cysteine desulfurase NifS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.


ensembl_gene_id: ANME2D_03443
symbol: iscU
gene_biotype: protein_coding
description:
  PFAM: NifU-like N terminal domain; TIGRFAM: FeS cluster assembly scaffold protein NifU, Clostridium type.


ensembl_gene_id: ANME2D_03447
symbol: thiC-3
gene_biotype: protein_coding
description:
  Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.


ensembl_gene_id: ANME2D_03450
symbol: KCZ70334.1
gene_biotype: protein_coding
description:
  Zinc metalloprotease (elastase); PFAM: Fungalysin/Thermolysin Propeptide Motif; Fungalysin metallopeptidase (M36); Peptidase propeptide and YPEB domain.


ensembl_gene_id: ANME2D_03455
symbol: KCZ70339.1
gene_biotype: protein_coding
description:
  Putative sugar kinase; Catalyzes the condensation of 4-aminobenzoate (pABA) with 5- phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta- ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).


ensembl_gene_id: ANME2D_03466
symbol: KCZ70350.1
gene_biotype: protein_coding
description:
  Nitrous oxide reductase; PFAM: Cytochrome C oxidase subunit II, periplasmic domain; IMG reference gene:2515324226_SP.


ensembl_gene_id: ANME2D_03470
symbol: KCZ70280.1
gene_biotype: protein_coding
description:
  Phosphate ABC transporter, permease protein PstC; Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.


ensembl_gene_id: ANME2D_03472
symbol: pstB-3
gene_biotype: protein_coding
description:
  Phosphate ABC transporter, ATP-binding protein; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.


ensembl_gene_id: ANME2D_03479
symbol: birA
gene_biotype: protein_coding
description:
  biotin-(acetyl-CoA carboxylase) ligase; PFAM: HTH domain; Biotin protein ligase C terminal domain; Biotin/lipoate A/B protein ligase family; TIGRFAM: BirA biotin operon repressor domain; birA, biotin-[acetyl-CoA-carboxylase] ligase region.


ensembl_gene_id: ANME2D_03480
symbol: accC
gene_biotype: protein_coding
description:
  acetyl-CoA carboxylase, biotin carboxylase subunit; PFAM: Carbamoyl-phosphate synthase L chain, ATP binding domain; Biotin carboxylase C-terminal domain; Carbamoyl-phosphate synthase L chain, N-terminal domain; TIGRFAM: acetyl-CoA carboxylase, biotin carboxylase subunit.


ensembl_gene_id: ANME2D_03481
symbol: pycB
gene_biotype: protein_coding
description:
  Pyruvate/oxaloacetate carboxyltransferase; PFAM: HMGL-like; Biotin-requiring enzyme; Conserved carboxylase domain; TIGRFAM: oxaloacetate decarboxylase alpha subunit.


