# geneInfo

ensembl_gene_id: HALO0025
symbol: rpoZ
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.


ensembl_gene_id: HALO0026
symbol: HALO0026
gene_biotype: protein_coding
description:
  Guanosine-3',5'-bis(Diphosphate) 3'-pyrophosphohydrolase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.


ensembl_gene_id: HALO0030
symbol: recG
gene_biotype: protein_coding
description:
  ATP-dependent DNA helicase recG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily.


ensembl_gene_id: HALO0040
symbol: HALO0040
gene_biotype: protein_coding
description:
  Histone-like DNA-binding protein; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.


ensembl_gene_id: HALO0042
symbol: ubiC
gene_biotype: protein_coding
description:
  Probable chorismate--pyruvate lyase; Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway; Belongs to the UbiC family.


ensembl_gene_id: HALO0043
symbol: ubiA
gene_biotype: protein_coding
description:
  4-hydroxybenzoate octaprenyltransferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.


ensembl_gene_id: HALO0050
symbol: cysZ
gene_biotype: protein_coding
description:
  Putative uncharacterized protein family CysZ; High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway; Belongs to the CysZ family.


ensembl_gene_id: HALO0051
symbol: HALO0051
gene_biotype: protein_coding
description:
  Phosphate-specific transport system accessory protein PhoU; Plays a role in the regulation of phosphate uptake.


ensembl_gene_id: HALO0052
symbol: pstB
gene_biotype: protein_coding
description:
  Phosphate transport system permease protein 1; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.


ensembl_gene_id: HALO0057
symbol: HALO0057
gene_biotype: protein_coding
description:
  TRAP transporter substrate-binding protein; Part of the tripartite ATP-independent periplasmic (TRAP) transport system.


ensembl_gene_id: HALO0071
symbol: aroQ
gene_biotype: protein_coding
description:
  3-dehydroquinate dehydratase-Type II DHQase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family.


ensembl_gene_id: HALO0103
symbol: HALO0103
gene_biotype: protein_coding
description:
  Vanillin synthase / trans-feruloyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family.


ensembl_gene_id: HALO0129
symbol: HALO0129
gene_biotype: protein_coding
description:
  Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.


ensembl_gene_id: HALO0135
symbol: mscL
gene_biotype: protein_coding
description:
  Large-conductance mechanosensitive channel; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.


ensembl_gene_id: HALO0139
symbol: HALO0139
gene_biotype: protein_coding
description:
  Uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.


ensembl_gene_id: HALO0140
symbol: hemC
gene_biotype: protein_coding
description:
  Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.


ensembl_gene_id: HALO0144
symbol: lysA
gene_biotype: protein_coding
description:
  Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine.


ensembl_gene_id: HALO0145
symbol: dapF
gene_biotype: protein_coding
description:
  Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan.


ensembl_gene_id: HALO0147
symbol: xerC
gene_biotype: protein_coding
description:
  Tyrosine recombinase XerC; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.


ensembl_gene_id: HALO0149
symbol: engB
gene_biotype: protein_coding
description:
  Probable GTP-binding protein EngB; Necessary for normal cell division and for the maintenance of normal septation; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.


ensembl_gene_id: HALO0155
symbol: HALO0155
gene_biotype: protein_coding
description:
  Extracellular solute-binding protein, family 7, bacteria; Part of the tripartite ATP-independent periplasmic (TRAP) transport system.


ensembl_gene_id: HALO0159
symbol: dtd
gene_biotype: protein_coding
description:
  D-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family.


ensembl_gene_id: HALO0173
symbol: trmB
gene_biotype: protein_coding
description:
  tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.


ensembl_gene_id: HALO0174
symbol: thiG
gene_biotype: protein_coding
description:
  Thiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.


ensembl_gene_id: HALO0196
symbol: glcB
gene_biotype: protein_coding
description:
  Malate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily.


ensembl_gene_id: HALO0206
symbol: lnt
gene_biotype: protein_coding
description:
  Apolipoprotein N-acyltransferase; Catalyzes the phospholipid dependent N-acylation of the N- terminal cysteine of apolipoprotein, the last step in lipoprotein maturation; Belongs to the CN hydrolase family. Apolipoprotein N- acyltransferase subfamily.


ensembl_gene_id: HALO0207
symbol: lspA
gene_biotype: protein_coding
description:
  Lipoprotein signal peptidase; This protein specifically catalyzes the removal of signal peptides from prolipoproteins; Belongs to the peptidase A8 family.


ensembl_gene_id: HALO0238
symbol: phnC
gene_biotype: protein_coding
description:
  Phosphonates import ATP-binding protein PhnC 1; Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphonates importer (TC 3.A.1.9.1) family.


ensembl_gene_id: HALO0246
symbol: HALO0246
gene_biotype: protein_coding
description:
  Extracellular solute-binding protein, family 3; Belongs to the bacterial solute-binding protein 3 family.


ensembl_gene_id: HALO0247
symbol: speE
gene_biotype: protein_coding
description:
  Spermidine synthase-Putrescine aminopropyltransferase-SPDSY; Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.


ensembl_gene_id: HALO0248
symbol: hemE
gene_biotype: protein_coding
description:
  Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.


ensembl_gene_id: HALO0249
symbol: ribA
gene_biotype: protein_coding
description:
  GTP cyclohydrolase-2-GTP cyclohydrolase II; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family.


ensembl_gene_id: HALO0251
symbol: HALO0251
gene_biotype: protein_coding
description:
  Protein phosphatase CheZ-Chemotaxis protein CheZ; Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P).


ensembl_gene_id: HALO0254
symbol: dxs
gene_biotype: protein_coding
description:
  1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily.


ensembl_gene_id: HALO0256
symbol: xseB
gene_biotype: protein_coding
description:
  Exodeoxyribonuclease 7 small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family.


ensembl_gene_id: HALO0257
symbol: HALO0257
gene_biotype: protein_coding
description:
  D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.


ensembl_gene_id: HALO0266
symbol: HALO0266
gene_biotype: protein_coding
description:
  Flagellin; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.


ensembl_gene_id: HALO0279
symbol: HALO0279
gene_biotype: protein_coding
description:
  ABC transporter, urea, permease protein, UrtB; Belongs to the binding-protein-dependent transport system permease family.


ensembl_gene_id: HALO0280
symbol: HALO0280
gene_biotype: protein_coding
description:
  Inner-membrane translocator; Belongs to the binding-protein-dependent transport system permease family.


ensembl_gene_id: HALO0286
symbol: HALO0286
gene_biotype: protein_coding
description:
  ABC transporter, metal-binding lipoprotein; Belongs to the bacterial solute-binding protein 9 family.


ensembl_gene_id: HALO0288
symbol: ureD
gene_biotype: protein_coding
description:
  Urease accessory protein UreD; Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.


ensembl_gene_id: HALO0292
symbol: ureE
gene_biotype: protein_coding
description:
  Urease accessory protein UreE; Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly. Belongs to the UreE family.


ensembl_gene_id: HALO0293
symbol: ureF
gene_biotype: protein_coding
description:
  Urease accessory protein UreF; Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.


ensembl_gene_id: HALO0294
symbol: ureG
gene_biotype: protein_coding
description:
  Urease accessory protein UreG; Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.


ensembl_gene_id: HALO0299
symbol: fdhD
gene_biotype: protein_coding
description:
  Protein FdhD homolog; Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Belongs to the FdhD family.


ensembl_gene_id: HALO0313
symbol: dsbD
gene_biotype: protein_coding
description:
  Thiol:disulfide interchange protein DsbD-Protein-disulfide reductase; Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps. Belongs to the thioredoxin family. DsbD subfamily.


ensembl_gene_id: HALO0315
symbol: HALO0315
gene_biotype: protein_coding
description:
  Thiol:disulfide interchange protein DsbG; Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process; Belongs to the thioredoxin family. DsbC subfamily.


ensembl_gene_id: HALO0338
symbol: HALO0338
gene_biotype: protein_coding
description:
  Tetrathionate reductase subunit A; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.


ensembl_gene_id: HALO0370
symbol: HALO0370
gene_biotype: protein_coding
description:
  ABC transporter, permease; Belongs to the binding-protein-dependent transport system permease family.


ensembl_gene_id: HALO0396
symbol: HALO0396
gene_biotype: protein_coding
description:
  Putative uncharacterized protein family UPF0271, LamB/YcsF; Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.


ensembl_gene_id: HALO0397
symbol: HALO0397
gene_biotype: protein_coding
description:
  Putative uncharacterized protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.


ensembl_gene_id: HALO0502
symbol: HALO0502
gene_biotype: protein_coding
description:
  Formate dehydrogenase, alpha subunit; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.


ensembl_gene_id: HALO0507
symbol: glyA
gene_biotype: protein_coding
description:
  Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.


ensembl_gene_id: HALO0512
symbol: purU
gene_biotype: protein_coding
description:
  Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).


ensembl_gene_id: HALO0524
symbol: znuC
gene_biotype: protein_coding
description:
  Zinc import ATP-binding protein ZnuC; Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Zinc importer (TC 3.A.1.15.5) family.


ensembl_gene_id: HALO0529
symbol: HALO0529
gene_biotype: protein_coding
description:
  Transcriptional regulator, LysR family protein; Belongs to the LysR transcriptional regulatory family.


ensembl_gene_id: HALO0530
symbol: HALO0530
gene_biotype: protein_coding
description:
  NAD(P) transhydrogenase subunit alpha; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the AlaDH/PNT family.


ensembl_gene_id: HALO0531
symbol: HALO0531
gene_biotype: protein_coding
description:
  NAD(P) transhydrogenase subunit beta; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family.


ensembl_gene_id: HALO0534
symbol: katG
gene_biotype: protein_coding
description:
  Catalase-peroxidase-Peroxidase/catalase; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity; Belongs to the peroxidase family. Peroxidase/catalase subfamily.


ensembl_gene_id: HALO0541
symbol: maiA
gene_biotype: protein_coding
description:
  Asp/Glu/hydantoin racemase; Catalyzes cis-trans isomerization of the C2-C3 double bond in maleate to yield fumarate.


ensembl_gene_id: HALO0551
symbol: pxpA
gene_biotype: protein_coding
description:
  UPF0271 protein HALTITAN_0179; Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.


ensembl_gene_id: HALO0561
symbol: HALO0561
gene_biotype: protein_coding
description:
  Ferric transporter subunit ATP-binding component of ABC transporter CP4-6 prophage; Belongs to the ABC transporter superfamily.


ensembl_gene_id: HALO0563
symbol: phnW
gene_biotype: protein_coding
description:
  2-aminoethylphosphonate--pyruvate transaminase; Involved in phosphonate degradation; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. PhnW subfamily.


ensembl_gene_id: HALO0564
symbol: phnX
gene_biotype: protein_coding
description:
  Phosphonoacetaldehyde hydrolase; Involved in phosphonate degradation; Belongs to the HAD-like hydrolase superfamily. PhnX family.


ensembl_gene_id: HALO0583
symbol: HALO0583
gene_biotype: protein_coding
description:
  3-oxoacyl-[acyl-carrier-protein] synthase 2; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.


ensembl_gene_id: HALO0586
symbol: HALO0586
gene_biotype: protein_coding
description:
  Cation/multidrug efflux system, membrane-fusion protein AcrA; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.


ensembl_gene_id: HALO0593
symbol: acdS
gene_biotype: protein_coding
description:
  1-aminocyclopropane-1-carboxylate deaminase; Catalyzes a cyclopropane ring-opening reaction, the irreversible conversion of 1-aminocyclopropane-1-carboxylate (ACC) to ammonia and alpha-ketobutyrate. Allows growth on ACC as a nitrogen source; Belongs to the ACC deaminase/D-cysteine desulfhydrase family.


ensembl_gene_id: HALO0607
symbol: HALO0607
gene_biotype: protein_coding
description:
  Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.


ensembl_gene_id: HALO0643
symbol: HALO0643
gene_biotype: protein_coding
description:
  Taurine--pyruvate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.


ensembl_gene_id: HALO0654
symbol: HALO0654
gene_biotype: protein_coding
description:
  Cation transport regulator-like protein 2; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.


ensembl_gene_id: HALO0657
symbol: HALO0657
gene_biotype: protein_coding
description:
  Cell division protein ZipA; Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins. Belongs to the ZipA family.


ensembl_gene_id: HALO0671
symbol: HALO0671
gene_biotype: protein_coding
description:
  4-aminobutyrate aminotransferase, bacterial; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.


ensembl_gene_id: HALO0678
symbol: menA
gene_biotype: protein_coding
description:
  1,4-dihydroxy-2-naphthoate octaprenyltransferase; Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK); Belongs to the MenA family. Type 1 subfamily.


ensembl_gene_id: HALO0679
symbol: menF
gene_biotype: protein_coding
description:
  Menaquinone-specific isochorismate synthase; Catalyzes the conversion of chorismate to isochorismate.


ensembl_gene_id: HALO0680
symbol: menD
gene_biotype: protein_coding
description:
  2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). Belongs to the TPP enzyme family. MenD subfamily.


ensembl_gene_id: HALO0681
symbol: menH
gene_biotype: protein_coding
description:
  Putative thioesterase, menaquinone synthesis; Catalyzes a proton abstraction reaction that results in 2,5- elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6- hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC).


ensembl_gene_id: HALO0684
symbol: HALO0684
gene_biotype: protein_coding
description:
  Fumarate reductase iron-sulfur subunit; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.


ensembl_gene_id: HALO0687
symbol: menB
gene_biotype: protein_coding
description:
  Dihydroxynaphthoic acid synthetase; Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA).


ensembl_gene_id: HALO0688
symbol: menC
gene_biotype: protein_coding
description:
  O-succinylbenzoate synthase; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB).


ensembl_gene_id: HALO0724
symbol: HALO0724
gene_biotype: protein_coding
description:
  Putative ABC transporter permease protein; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.


ensembl_gene_id: HALO0741
symbol: HALO0741
gene_biotype: protein_coding
description:
  Acriflavin resistance protein; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.


ensembl_gene_id: HALO0753
symbol: HALO0753
gene_biotype: protein_coding
description:
  Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate; Belongs to the radical SAM superfamily. MoaA family.


ensembl_gene_id: HALO0754
symbol: HALO0754
gene_biotype: protein_coding
description:
  Molybdopterin molybdochelatase; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family.


ensembl_gene_id: HALO0755
symbol: mobA
gene_biotype: protein_coding
description:
  Molybdenum cofactor guanylyltransferase; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor; Belongs to the MobA family.


ensembl_gene_id: HALO0756
symbol: fdhD-2
gene_biotype: protein_coding
description:
  Formate dehydrogenase, subunit FdhD; Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Belongs to the FdhD family.


ensembl_gene_id: HALO0762
symbol: HALO0762
gene_biotype: protein_coding
description:
  Molybdopterin oxidoreductase; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.


ensembl_gene_id: HALO0766
symbol: HALO0766
gene_biotype: protein_coding
description:
  Molybdenum cofactor biosynthesis protein B; May be involved in the biosynthesis of molybdopterin. Belongs to the MoaB/Mog family.


ensembl_gene_id: HALO0767
symbol: HALO0767
gene_biotype: protein_coding
description:
  Molybdopterin molybdenumtransferase; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family.


ensembl_gene_id: HALO0774
symbol: cheB
gene_biotype: protein_coding
description:
  Chemotaxis response regulator protein-glutamate methylesterase; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family.


ensembl_gene_id: HALO0803
symbol: mtnK
gene_biotype: protein_coding
description:
  Methylthioribose kinase; Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate.


ensembl_gene_id: HALO0804
symbol: mtnD
gene_biotype: protein_coding
description:
  Acireductone dioxygenase; Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.


ensembl_gene_id: HALO0805
symbol: mtnC
gene_biotype: protein_coding
description:
  Enolase-phosphatase E1-2,3-diketo-5-methylthio-1-phosphopentane phosphatase; Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.


ensembl_gene_id: HALO0806
symbol: mtnB
gene_biotype: protein_coding
description:
  Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Belongs to the aldolase class II family. MtnB subfamily.


ensembl_gene_id: HALO0807
symbol: mtnA
gene_biotype: protein_coding
description:
  Methylthioribose-1-phosphate isomerase-S-methyl-5-thioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).


ensembl_gene_id: HALO0814
symbol: HALO0814
gene_biotype: protein_coding
description:
  Putative sugar transporter subunit: ATP-binding component of ABC superfamily transporter; Belongs to the ABC transporter superfamily.


ensembl_gene_id: HALO0857
symbol: araG
gene_biotype: protein_coding
description:
  Arabinose import ATP-binding protein AraG; Part of the ABC transporter complex AraFGH involved in arabinose import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Arabinose importer (TC 3.A.1.2.2) family.


ensembl_gene_id: HALO0875
symbol: HALO0875
gene_biotype: protein_coding
description:
  General substrate transporter; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.


ensembl_gene_id: HALO0891
symbol: HALO0891
gene_biotype: protein_coding
description:
  Flagellar hook-associated protein 2; Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.


ensembl_gene_id: HALO0904
symbol: HALO0904
gene_biotype: protein_coding
description:
  Flagellin-Phase 1-C flagellin; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.


ensembl_gene_id: HALO0910
symbol: murJ
gene_biotype: protein_coding
description:
  Virulence factor; Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.


ensembl_gene_id: HALO0912
symbol: ileS
gene_biotype: protein_coding
description:
  Isoleucine--tRNA ligase-Isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.


ensembl_gene_id: HALO0915
symbol: ispH
gene_biotype: protein_coding
description:
  4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family.


ensembl_gene_id: HALO0920
symbol: trpS
gene_biotype: protein_coding
description:
  Tryptophan--tRNA ligase-Tryptophanyl-tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family.


ensembl_gene_id: HALO0953
symbol: nadE
gene_biotype: protein_coding
description:
  Glutamine-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.


ensembl_gene_id: HALO0956
symbol: bamD
gene_biotype: protein_coding
description:
  Outer membrane protein assembly factor BamD; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.


ensembl_gene_id: HALO0957
symbol: HALO0957
gene_biotype: protein_coding
description:
  Pseudouridine synthase; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family.


ensembl_gene_id: HALO0958
symbol: HALO0958
gene_biotype: protein_coding
description:
  Multi-copper polyphenol oxidoreductase, laccase; Belongs to the multicopper oxidase YfiH/RL5 family.


ensembl_gene_id: HALO0959
symbol: clpB
gene_biotype: protein_coding
description:
  Chaperonin ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family.


ensembl_gene_id: HALO0962
symbol: HALO0962
gene_biotype: protein_coding
description:
  CDP-diacylglycerol--serineO- phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.


ensembl_gene_id: HALO0963
symbol: hisC
gene_biotype: protein_coding
description:
  Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.


ensembl_gene_id: HALO0965
symbol: radA
gene_biotype: protein_coding
description:
  Repair protein radA homolog; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.


ensembl_gene_id: HALO0967
symbol: selU
gene_biotype: protein_coding
description:
  tRNA 2-selenouridine synthase; Involved in the post-transcriptional modification of the uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Catalyzes the conversion of 2-thiouridine (S2U-RNA) to 2- selenouridine (Se2U-RNA). Acts in a two-step process involving geranylation of 2-thiouridine (S2U) to S-geranyl-2-thiouridine (geS2U) and subsequent selenation of the latter derivative to 2-selenouridine (Se2U) in the tRNA chain.


ensembl_gene_id: HALO0971
symbol: hisF
gene_biotype: protein_coding
description:
  Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.


ensembl_gene_id: HALO0972
symbol: hisA
gene_biotype: protein_coding
description:
  1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase.


ensembl_gene_id: HALO0973
symbol: hisH
gene_biotype: protein_coding
description:
  Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.


ensembl_gene_id: HALO0978
symbol: HALO0978
gene_biotype: protein_coding
description:
  Probable Fe(2+)-trafficking protein; Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes.


ensembl_gene_id: HALO0984
symbol: polA
gene_biotype: protein_coding
description:
  DNA polymerase 1; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.


ensembl_gene_id: HALO0995
symbol: HALO0995
gene_biotype: protein_coding
description:
  Putative uncharacterized protein; Part of the tripartite ATP-independent periplasmic (TRAP) transport system.


ensembl_gene_id: HALO0996
symbol: tmcA
gene_biotype: protein_coding
description:
  tRNA(Met) cytidine acetyltransferase TmcA; Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).


ensembl_gene_id: HALO1014
symbol: coaD
gene_biotype: protein_coding
description:
  Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family.


ensembl_gene_id: HALO1015
symbol: HALO1015
gene_biotype: protein_coding
description:
  Beta-ketoacyl synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.


ensembl_gene_id: HALO1019
symbol: HALO1019
gene_biotype: protein_coding
description:
  Diacylglycerol kinase; Recycling of diacylglycerol produced during the turnover of membrane phospholipid.


ensembl_gene_id: HALO1020
symbol: glnE
gene_biotype: protein_coding
description:
  Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...]


ensembl_gene_id: HALO1034
symbol: metE
gene_biotype: protein_coding
description:
  5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.


ensembl_gene_id: HALO1035
symbol: ppk
gene_biotype: protein_coding
description:
  Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family.


ensembl_gene_id: HALO1037
symbol: HALO1037
gene_biotype: protein_coding
description:
  Enhancing lycopene biosynthesis protein 2; Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate; Belongs to the peptidase C56 family.


ensembl_gene_id: HALO1038
symbol: tatC
gene_biotype: protein_coding
description:
  Sec-independent protein translocase protein TatC; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.


ensembl_gene_id: HALO1039
symbol: tatB
gene_biotype: protein_coding
description:
  Sec-independent protein translocase protein TatB; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.


ensembl_gene_id: HALO1040
symbol: tatA
gene_biotype: protein_coding
description:
  Sec-independent protein translocase protein TatA; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.


ensembl_gene_id: HALO1042
symbol: ubiB
gene_biotype: protein_coding
description:
  Putative ubiquinone biosynthesis protein UbiB; Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis.


ensembl_gene_id: HALO1044
symbol: ubiE
gene_biotype: protein_coding
description:
  Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2).


ensembl_gene_id: HALO1046
symbol: hslU
gene_biotype: protein_coding
description:
  ATP-dependent protease ATPase subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.


ensembl_gene_id: HALO1047
symbol: hslV
gene_biotype: protein_coding
description:
  ATP-dependent protease subunit HslV; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.


ensembl_gene_id: HALO1050
symbol: priA
gene_biotype: protein_coding
description:
  Primosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily.


ensembl_gene_id: HALO1054
symbol: tadA
gene_biotype: protein_coding
description:
  tRNA-specific adenosine deaminase; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family.


ensembl_gene_id: HALO1056
symbol: mltF
gene_biotype: protein_coding
description:
  Membrane-bound lytic murein transglycosylase F; Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella.


ensembl_gene_id: HALO1057
symbol: purL
gene_biotype: protein_coding
description:
  Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.


ensembl_gene_id: HALO1062
symbol: HALO1062
gene_biotype: protein_coding
description:
  Prokaryotic chromosome segregation/condensation protein ScpA; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves.


ensembl_gene_id: HALO1063
symbol: HALO1063
gene_biotype: protein_coding
description:
  Chromosome segregation/condensation protein ScpB, prokaryote; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves.


ensembl_gene_id: HALO1065
symbol: HALO1065
gene_biotype: protein_coding
description:
  Quinolinate synthetase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.


ensembl_gene_id: HALO1066
symbol: HALO1066
gene_biotype: protein_coding
description:
  Putative peptidase; Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state.


ensembl_gene_id: HALO1070
symbol: dapA
gene_biotype: protein_coding
description:
  4-hydroxy-tetrahydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).


ensembl_gene_id: HALO1077
symbol: HALO1077
gene_biotype: protein_coding
description:
  Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).


ensembl_gene_id: HALO1078
symbol: HALO1078
gene_biotype: protein_coding
description:
  Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).


ensembl_gene_id: HALO1079
symbol: adk
gene_biotype: protein_coding
description:
  Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.


ensembl_gene_id: HALO1081
symbol: rsmJ
gene_biotype: protein_coding
description:
  Ribosomal RNA small subunit methyltransferase J; Specifically methylates the guanosine in position 1516 of 16S rRNA.


ensembl_gene_id: HALO1085
symbol: acsA
gene_biotype: protein_coding
description:
  Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.


ensembl_gene_id: HALO1093
symbol: ttcA
gene_biotype: protein_coding
description:
  tRNA 2-thiocytidine biosynthesis protein TtcA; Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.


ensembl_gene_id: HALO1095
symbol: HALO1095
gene_biotype: protein_coding
description:
  Oxygen-independent coproporphyrinogen-III oxidase; Belongs to the anaerobic coproporphyrinogen-III oxidase family.


ensembl_gene_id: HALO1101
symbol: HALO1101
gene_biotype: protein_coding
description:
  Cbb3-type cytochrome c oxidase subunit; C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex.


ensembl_gene_id: HALO1121
symbol: HALO1121
gene_biotype: protein_coding
description:
  L-lactate transport; Transports L-lactate across the membrane. Can also transport D-lactate and glycolate; Belongs to the lactate permease family.


ensembl_gene_id: HALO1127
symbol: HALO1127
gene_biotype: protein_coding
description:
  5-hydroxyisourate hydrolase 2; Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.


ensembl_gene_id: HALO1131
symbol: ilvC
gene_biotype: protein_coding
description:
  Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.


ensembl_gene_id: HALO1157
symbol: HALO1157
gene_biotype: protein_coding
description:
  Molybdenum transport system permease protein modB; Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.


ensembl_gene_id: HALO1204
symbol: HALO1204
gene_biotype: protein_coding
description:
  Putative H+-transporting two-sector ATPase, gamma subunit (AcrC-family protein); Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.


ensembl_gene_id: HALO1208
symbol: HALO1208
gene_biotype: protein_coding
description:
  Putative uncharacterized protein; Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.


ensembl_gene_id: HALO1233
symbol: HALO1233
gene_biotype: protein_coding
description:
  Putative uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.


ensembl_gene_id: HALO1236
symbol: luxS
gene_biotype: protein_coding
description:
  Autoinducer-2 production protein LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family.


ensembl_gene_id: HALO1251
symbol: crcB
gene_biotype: protein_coding
description:
  Putative fluoride ion transporter CrcB; Important for reducing fluoride concentration in the cell, thus reducing its toxicity; Belongs to the CrcB (TC 9.B.71) family.


ensembl_gene_id: HALO1255
symbol: leuA
gene_biotype: protein_coding
description:
  2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.


ensembl_gene_id: HALO1263
symbol: ftsB
gene_biotype: protein_coding
description:
  Cell division protein FtsB; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.


ensembl_gene_id: HALO1264
symbol: ispD
gene_biotype: protein_coding
description:
  2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).


ensembl_gene_id: HALO1265
symbol: ispF
gene_biotype: protein_coding
description:
  2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).


ensembl_gene_id: HALO1266
symbol: truD
gene_biotype: protein_coding
description:
  tRNA pseudouridine synthase D; Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs; Belongs to the pseudouridine synthase TruD family.


ensembl_gene_id: HALO1267
symbol: surE
gene_biotype: protein_coding
description:
  5'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.


ensembl_gene_id: HALO1268
symbol: pcm
gene_biotype: protein_coding
description:
  Protein-L-isoaspartate O-methyltransferase; Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.


ensembl_gene_id: HALO1271
symbol: rpoS
gene_biotype: protein_coding
description:
  RNA polymerase sigma factor RpoS; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response.


ensembl_gene_id: HALO1272
symbol: HALO1272
gene_biotype: protein_coding
description:
  Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family.


ensembl_gene_id: HALO1274
symbol: speD
gene_biotype: protein_coding
description:
  S-adenosylmethionine decarboxylase proenzyme; Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine; Belongs to the prokaryotic AdoMetDC family. Type 2 subfamily.


ensembl_gene_id: HALO1279
symbol: lptD
gene_biotype: protein_coding
description:
  Organic solvent tolerance protein; Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.


ensembl_gene_id: HALO1281
symbol: pdxA
gene_biotype: protein_coding
description:
  4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).


ensembl_gene_id: HALO1282
symbol: rsmA
gene_biotype: protein_coding
description:
  Ribosomal RNA small subunit methyltransferase A; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.


ensembl_gene_id: HALO1286
symbol: apaH
gene_biotype: protein_coding
description:
  Bis(5'-nucleosyl)-tetraphosphatase, symmetrical; Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP; Belongs to the Ap4A hydrolase family.


ensembl_gene_id: HALO1287
symbol: HALO1287
gene_biotype: protein_coding
description:
  Putative uncharacterized protein; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.


ensembl_gene_id: HALO1289
symbol: HALO1289
gene_biotype: protein_coding
description:
  Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin.


ensembl_gene_id: HALO1290
symbol: plsY
gene_biotype: protein_coding
description:
  Glycerol-3-phosphate acyltransferase; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.


ensembl_gene_id: HALO1291
symbol: tsaD
gene_biotype: protein_coding
description:
  tRNA N6-adenosine threonylcarbamoyltransferase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family.


ensembl_gene_id: HALO1293
symbol: dnaG
gene_biotype: protein_coding
description:
  DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.


ensembl_gene_id: HALO1294
symbol: rpoD
gene_biotype: protein_coding
description:
  RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.


ensembl_gene_id: HALO1300
symbol: HALO1300
gene_biotype: protein_coding
description:
  S-(Hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.


ensembl_gene_id: HALO1302
symbol: mtgA
gene_biotype: protein_coding
description:
  Monofunctional biosynthetic peptidoglycan transglycosylase; Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors; Belongs to the glycosyltransferase 51 family.


ensembl_gene_id: HALO1317
symbol: HALO1317
gene_biotype: protein_coding
description:
  Iron-regulated virulence regulatory protein irgB; Belongs to the LysR transcriptional regulatory family.


ensembl_gene_id: HALO1321
symbol: HALO1321
gene_biotype: protein_coding
description:
  Iron-dicitrate transporter subunit membrane component of ABC superfamily KpLE2 phage-like element; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.


ensembl_gene_id: HALO1348
symbol: HALO1348
gene_biotype: protein_coding
description:
  Iron-dicitrate transporter subunit ATP-binding component of ABC superfamily KpLE2 phage-like element.


ensembl_gene_id: HALO1357
symbol: sstT
gene_biotype: protein_coding
description:
  Serine/threonine transporter SstT-Na(+)/serine-threonine symporter; Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system). Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.


ensembl_gene_id: HALO1360
symbol: HALO1360
gene_biotype: protein_coding
description:
  Phosphatidylglycerophosphate synthase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.


ensembl_gene_id: HALO1362
symbol: sbcD
gene_biotype: protein_coding
description:
  Nuclease sbcCD subunit D; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family.


ensembl_gene_id: HALO1365
symbol: HALO1365
gene_biotype: protein_coding
description:
  Phosphatidylglycerophosphatase A; Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG).


ensembl_gene_id: HALO1367
symbol: msrA
gene_biotype: protein_coding
description:
  Peptide methionine sulfoxide reductase MsrA-Peptide-methionine (S)-S-oxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.


ensembl_gene_id: HALO1380
symbol: HALO1380
gene_biotype: protein_coding
description:
  Winged helix-turn-helix transcription repressor, DNA-binding; Belongs to the LysR transcriptional regulatory family.


ensembl_gene_id: HALO1384
symbol: HALO1384
gene_biotype: protein_coding
description:
  Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase YbaK; Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily.


ensembl_gene_id: HALO1387
symbol: HALO1387
gene_biotype: protein_coding
description:
  Transketolase 1; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.


ensembl_gene_id: HALO1388
symbol: HALO1388
gene_biotype: protein_coding
description:
  Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 1 subfamily.


ensembl_gene_id: HALO1395
symbol: HALO1395
gene_biotype: protein_coding
description:
  Ribose transport system permease protein RbsC; Belongs to the binding-protein-dependent transport system permease family.


ensembl_gene_id: HALO1398
symbol: ribH
gene_biotype: protein_coding
description:
  6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family.


ensembl_gene_id: HALO1419
symbol: HALO1419
gene_biotype: protein_coding
description:
  Restriction system protein; Predicted endonuclease distantly related to archaeal Holliday junction resolvase and Mrr-like restriction enzymes.


ensembl_gene_id: HALO1431
symbol: fabV
gene_biotype: protein_coding
description:
  Putative reductase HALTITAN_2691; Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon- carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP); Belongs to the TER reductase family.


ensembl_gene_id: HALO1437
symbol: argD
gene_biotype: protein_coding
description:
  Acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.


ensembl_gene_id: HALO1440
symbol: astD
gene_biotype: protein_coding
description:
  N-succinylglutamate 5-semialdehyde dehydrogenase; Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate.


ensembl_gene_id: HALO1441
symbol: astB
gene_biotype: protein_coding
description:
  N-succinylarginine dihydrolase; Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)- succinylornithine, ammonia and CO(2).


ensembl_gene_id: HALO1497
symbol: HALO1497
gene_biotype: protein_coding
description:
  Putative uncharacterized protein; Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity. Belongs to the AhpD family.


ensembl_gene_id: HALO1500
symbol: corA
gene_biotype: protein_coding
description:
  Putative metal ion transporter yfjQ; Mediates influx of magnesium ions. Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.


ensembl_gene_id: HALO1522
symbol: ybeY
gene_biotype: protein_coding
description:
  Endoribonuclease YbeY; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.


ensembl_gene_id: HALO1524
symbol: miaB
gene_biotype: protein_coding
description:
  (Dimethylallyl)adenosine tRNA methylthiotransferase MiaB; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.


ensembl_gene_id: HALO1528
symbol: ychF
gene_biotype: protein_coding
description:
  GTP-dependent nucleic acid-binding protein engD; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.


ensembl_gene_id: HALO1529
symbol: pth
gene_biotype: protein_coding
description:
  Peptidyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family.


ensembl_gene_id: HALO1530
symbol: rplY
gene_biotype: protein_coding
description:
  50S ribosomal protein L25; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.


ensembl_gene_id: HALO1531
symbol: prs
gene_biotype: protein_coding
description:
  Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.


ensembl_gene_id: HALO1532
symbol: ispE
gene_biotype: protein_coding
description:
  4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.


ensembl_gene_id: HALO1533
symbol: lolB
gene_biotype: protein_coding
description:
  Outer-membrane lipoprotein LolB; Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein.


ensembl_gene_id: HALO1535
symbol: hemA
gene_biotype: protein_coding
description:
  Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).


ensembl_gene_id: HALO1536
symbol: prfA
gene_biotype: protein_coding
description:
  Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.


ensembl_gene_id: HALO1537
symbol: prmC
gene_biotype: protein_coding
description:
  Release factor glutamine methyltransferase; Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif; Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.


ensembl_gene_id: HALO1564
symbol: trpB
gene_biotype: protein_coding
description:
  Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.


ensembl_gene_id: HALO1565
symbol: trpA
gene_biotype: protein_coding
description:
  Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.


ensembl_gene_id: HALO1580
symbol: potA
gene_biotype: protein_coding
description:
  ABC transporter ATP-binding protein; Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.


ensembl_gene_id: HALO1612
symbol: tpiA
gene_biotype: protein_coding
description:
  Triosephosphate isomerase-Triose-phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family.


ensembl_gene_id: HALO1613
symbol: HALO1613
gene_biotype: protein_coding
description:
  Putative D-3-phosphoglycerate dehydrogenase (PGDH); Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.


ensembl_gene_id: HALO1653
symbol: HALO1653
gene_biotype: protein_coding
description:
  Short chain dehydrogenase/reductase family protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.


ensembl_gene_id: HALO1661
symbol: recD
gene_biotype: protein_coding
description:
  Exodeoxyribonuclease V, subunit alpha; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and r [...]


ensembl_gene_id: HALO1662
symbol: recB
gene_biotype: protein_coding
description:
  Exodeoxyribonuclease V beta chain; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repai [...]


ensembl_gene_id: HALO1665
symbol: pncB
gene_biotype: protein_coding
description:
  Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family.


ensembl_gene_id: HALO1666
symbol: recC
gene_biotype: protein_coding
description:
  Exodeoxyribonuclease V, subunit gamma; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and r [...]


ensembl_gene_id: HALO1671
symbol: purE
gene_biotype: protein_coding
description:
  Phosphoribosylaminoimidazole carboxylase, core; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).


ensembl_gene_id: HALO1672
symbol: purK
gene_biotype: protein_coding
description:
  Phosphoribosylaminoimidazole carboxylase ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).


ensembl_gene_id: HALO1679
symbol: astE
gene_biotype: protein_coding
description:
  Succinylglutamate desuccinylase; Transforms N(2)-succinylglutamate into succinate and glutamate; Belongs to the AspA/AstE family. Succinylglutamate desuccinylase subfamily.


ensembl_gene_id: HALO1684
symbol: HALO1684
gene_biotype: protein_coding
description:
  Putative DNA-binding transcriptional regulator; Belongs to the LysR transcriptional regulatory family.


ensembl_gene_id: HALO1685
symbol: HALO1685
gene_biotype: protein_coding
description:
  Outer membrane lipoprotein blc; Involved in the storage or transport of lipids necessary for membrane maintenance under stressful conditions. Displays a binding preference for lysophospholipids.


ensembl_gene_id: HALO1693
symbol: azoR
gene_biotype: protein_coding
description:
  FMN-dependent NADH-azoreductase; Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity; Belongs to the azoreductase type 1 family.


ensembl_gene_id: HALO1698
symbol: HALO1698
gene_biotype: protein_coding
description:
  Low specificity L-threonine aldolase; Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde.


ensembl_gene_id: HALO1702
symbol: HALO1702
gene_biotype: protein_coding
description:
  High-potential iron-sulfur protein; Specific class of high-redox-potential 4Fe-4S ferredoxins. Functions in anaerobic electron transport in most purple and in some other photosynthetic bacteria and in at least one genus (Paracoccus) of halophilic, denitrifying bacteria; Belongs to the high-potential iron-sulfur protein (HiPIP) family.


ensembl_gene_id: HALO1709
symbol: rnr
gene_biotype: protein_coding
description:
  Ribonuclease R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.


ensembl_gene_id: HALO1710
symbol: rlmB
gene_biotype: protein_coding
description:
  RNA methyltransferase TrmH, group 3; Specifically methylates the ribose of guanosine 2251 in 23S rRNA.


ensembl_gene_id: HALO1712
symbol: rpsR
gene_biotype: protein_coding
description:
  30S ribosomal protein S18; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family.


ensembl_gene_id: HALO1715
symbol: HALO1715
gene_biotype: protein_coding
description:
  Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily.


ensembl_gene_id: HALO1720
symbol: hemH
gene_biotype: protein_coding
description:
  Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.


ensembl_gene_id: HALO1732
symbol: HALO1732
gene_biotype: protein_coding
description:
  Ribosomal RNA small subunit methyltransferase E; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.


ensembl_gene_id: HALO1738
symbol: coq7
gene_biotype: protein_coding
description:
  2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Catalyzes the hydroxylation of 2-nonaprenyl-3-methyl-6- methoxy-1,4-benzoquinol during ubiquinone biosynthesis.


ensembl_gene_id: HALO1767
symbol: uppP
gene_biotype: protein_coding
description:
  Bacitracin resistance protein; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family.


ensembl_gene_id: HALO1768
symbol: HALO1768
gene_biotype: protein_coding
description:
  Thiamine biosynthesis lipoprotein; Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein. Belongs to the ApbE family.


ensembl_gene_id: HALO1769
symbol: corA-2
gene_biotype: protein_coding
description:
  Magnesium and cobalt transport protein CorA; Mediates influx of magnesium ions. Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.


ensembl_gene_id: HALO1798
symbol: prmB
gene_biotype: protein_coding
description:
  50S ribosomal protein L3 glutamine methyltransferase; Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue; Belongs to the protein N5-glutamine methyltransferase family. PrmB subfamily.


ensembl_gene_id: HALO1799
symbol: aroC
gene_biotype: protein_coding
description:
  Chorismate synthase-5-enolpyruvylshikimate-3-phosphate phospholyase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.


ensembl_gene_id: HALO1804
symbol: HALO1804
gene_biotype: protein_coding
description:
  Alkyl hydroperoxide reductase subunit C; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.


ensembl_gene_id: HALO1805
symbol: HALO1805
gene_biotype: protein_coding
description:
  Bacterial periplasmic spermidine/putrescine-binding protein; Required for the activity of the bacterial periplasmic transport system of putrescine; Belongs to the bacterial solute-binding protein PotD/PotF family.


ensembl_gene_id: HALO1806
symbol: potA-2
gene_biotype: protein_coding
description:
  Spermidine/putrescine import ATP-binding protein PotA; Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.


ensembl_gene_id: HALO1811
symbol: HALO1811
gene_biotype: protein_coding
description:
  Putative uncharacterized protein; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.


ensembl_gene_id: HALO1817
symbol: HALO1817
gene_biotype: protein_coding
description:
  Phospholipase A1; Hydrolysis of phosphatidylcholine with phospholipase A2 (EC 3.1.1.4) and phospholipase A1 (EC 3.1.1.32) activities. Belongs to the phospholipase A1 family.


ensembl_gene_id: HALO1824
symbol: tpm
gene_biotype: protein_coding
description:
  Thiopurine methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.


ensembl_gene_id: HALO1827
symbol: cysA
gene_biotype: protein_coding
description:
  ABC transporter ATP-binding protein; Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system.


ensembl_gene_id: HALO1829
symbol: HALO1829
gene_biotype: protein_coding
description:
  Sulfate ABC transporter, permease protein CysT; Part of the ABC transporter complex (TC 3.A.1.6.1) involved in sulfate/thiosulfate import; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.


ensembl_gene_id: HALO1833
symbol: HALO1833
gene_biotype: protein_coding
description:
  Phosphoglycolate phosphatase; Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.


ensembl_gene_id: HALO1834
symbol: HALO1834
gene_biotype: protein_coding
description:
  Periplasmic chelated iron-binding protein yfeA; Belongs to the bacterial solute-binding protein 9 family.


ensembl_gene_id: HALO1836
symbol: trpD
gene_biotype: protein_coding
description:
  Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA).


ensembl_gene_id: HALO1842
symbol: HALO1842
gene_biotype: protein_coding
description:
  Sodium:dicarboxylate symporter; Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.


ensembl_gene_id: HALO1845
symbol: serS
gene_biotype: protein_coding
description:
  Serine--tRNA ligase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec).


ensembl_gene_id: HALO1853
symbol: prpB
gene_biotype: protein_coding
description:
  Methylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.


ensembl_gene_id: HALO1859
symbol: pyrF
gene_biotype: protein_coding
description:
  Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily.


ensembl_gene_id: HALO1860
symbol: lapB
gene_biotype: protein_coding
description:
  Putative uncharacterized protein; Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane; Belongs to the LapB family.


ensembl_gene_id: HALO1862
symbol: ihfB
gene_biotype: protein_coding
description:
  Integration host factor subunit beta; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family.


ensembl_gene_id: HALO1866
symbol: HALO1866
gene_biotype: protein_coding
description:
  CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltrans; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.


ensembl_gene_id: HALO1867
symbol: uvrC
gene_biotype: protein_coding
description:
  UvrABC system protein C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.


ensembl_gene_id: HALO1869
symbol: HALO1869
gene_biotype: protein_coding
description:
  Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.


ensembl_gene_id: HALO1872
symbol: dnaX
gene_biotype: protein_coding
description:
  DNA polymerase III, subunit gamma/ tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.


ensembl_gene_id: HALO1873
symbol: HALO1873
gene_biotype: protein_coding
description:
  Nucleoid-associated protein ybaB; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.


ensembl_gene_id: HALO1874
symbol: recR
gene_biotype: protein_coding
description:
  Recombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.


ensembl_gene_id: HALO1875
symbol: rnd
gene_biotype: protein_coding
description:
  Ribonuclease D; Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides; Belongs to the RNase D family.


ensembl_gene_id: HALO1892
symbol: HALO1892
gene_biotype: protein_coding
description:
  Phosphate ABC transporter, permease protein PstC; Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.


ensembl_gene_id: HALO1895
symbol: HALO1895
gene_biotype: protein_coding
description:
  Glyceraldehyde-3-phosphate dehydrogenase 3; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.


ensembl_gene_id: HALO1907
symbol: HALO1907
gene_biotype: protein_coding
description:
  Putative arsenate reductase ArsC2; Belongs to the low molecular weight phosphotyrosine protein phosphatase family.


ensembl_gene_id: HALO1913
symbol: HALO1913
gene_biotype: protein_coding
description:
  3-hydroxyacyl-CoA dehydrogenase type-2; Belongs to the short-chain dehydrogenases/reductases (SDR) family.


ensembl_gene_id: HALO1915
symbol: rlmM
gene_biotype: protein_coding
description:
  Ribosomal RNA large subunit methyltransferase RlmM; Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily.


ensembl_gene_id: HALO1935
symbol: HALO1935
gene_biotype: protein_coding
description:
  Fatty oxidation complex, alpha subunit FadB; Involved in the aerobic and anaerobic degradation of long- chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate. In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.


ensembl_gene_id: HALO1936
symbol: fadA
gene_biotype: protein_coding
description:
  3-ketoacyl-CoA thiolase; Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.


ensembl_gene_id: HALO1947
symbol: HALO1947
gene_biotype: protein_coding
description:
  Cysteine sulfinate desulfinase; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.


ensembl_gene_id: HALO1962
symbol: HALO1962
gene_biotype: protein_coding
description:
  Bifunctional protein PutA; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family.


ensembl_gene_id: HALO1963
symbol: HALO1963
gene_biotype: protein_coding
description:
  Sodium/proline symporter; Catalyzes the sodium-dependent uptake of extracellular L- proline; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.


ensembl_gene_id: HALO1969
symbol: nadK
gene_biotype: protein_coding
description:
  Probable inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.


ensembl_gene_id: HALO1991
symbol: HALO1991
gene_biotype: protein_coding
description:
  Glyceraldehyde/Erythrose phosphate dehydrogenase family; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.


ensembl_gene_id: HALO1999
symbol: malT
gene_biotype: protein_coding
description:
  Transcriptional regulator MalT; Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto- oligosaccharides. Specifically binds to the promoter region of its target genes, recognizing a short DNA motif called the MalT box.


ensembl_gene_id: HALO2006
symbol: kdpA
gene_biotype: protein_coding
description:
  Potassium-transporting ATPase A chain-ATP phosphohydrolase; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane.


ensembl_gene_id: HALO2007
symbol: kdpB
gene_biotype: protein_coding
description:
  Potassium-transporting ATPase B chain-ATP phosphohydrolase; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.


ensembl_gene_id: HALO2008
symbol: kdpC
gene_biotype: protein_coding
description:
  Potassium-transporting ATPase C chain-ATP phosphohydrolase; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.


ensembl_gene_id: HALO2014
symbol: HALO2014
gene_biotype: protein_coding
description:
  Maltose-binding periplasmic protein; Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Binds maltose and higher maltodextrins. Belongs to the bacterial solute-binding protein 1 family.


ensembl_gene_id: HALO2018
symbol: zwf
gene_biotype: protein_coding
description:
  Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone.


ensembl_gene_id: HALO2030
symbol: edd
gene_biotype: protein_coding
description:
  Phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family.


ensembl_gene_id: HALO2031
symbol: cobT
gene_biotype: protein_coding
description:
  Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).


ensembl_gene_id: HALO2032
symbol: cobD
gene_biotype: protein_coding
description:
  Cobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.


ensembl_gene_id: HALO2034
symbol: HALO2034
gene_biotype: protein_coding
description:
  Cobinamide kinase/cobinamide phosphate guanyltransferase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.


ensembl_gene_id: HALO2035
symbol: cobS
gene_biotype: protein_coding
description:
  Cobalamin synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family.


ensembl_gene_id: HALO2041
symbol: HALO2041
gene_biotype: protein_coding
description:
  Putative uncharacterized protein; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.


ensembl_gene_id: HALO2049
symbol: HALO2049
gene_biotype: protein_coding
description:
  Cob(I)yrinic acid a,c-diamide adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids.


ensembl_gene_id: HALO2055
symbol: HALO2055
gene_biotype: protein_coding
description:
  Cobalamin (Vitamin B12) biosynthesis CobI/CbiL, precorrin-2; Belongs to the precorrin methyltransferase family.


ensembl_gene_id: HALO2065
symbol: rho
gene_biotype: protein_coding
description:
  Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template.


ensembl_gene_id: HALO2077
symbol: HALO2077
gene_biotype: protein_coding
description:
  Carboxymuconolactone decarboxylase; Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity. Belongs to the AhpD family.


ensembl_gene_id: HALO2092
symbol: cpdA
gene_biotype: protein_coding
description:
  3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.


ensembl_gene_id: HALO2098
symbol: cobQ
gene_biotype: protein_coding
description:
  Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily.


ensembl_gene_id: HALO2113
symbol: pepQ
gene_biotype: protein_coding
description:
  Xaa-Pro dipeptidase-Imidodipeptidase-Proline dipeptidase; Splits dipeptides with a prolyl residue in the C-terminal position.


ensembl_gene_id: HALO2115
symbol: HALO2115
gene_biotype: protein_coding
description:
  Putative oligopeptide transport ATP-binding protein ykfD; Belongs to the ABC transporter superfamily.


ensembl_gene_id: HALO2122
symbol: mpl
gene_biotype: protein_coding
description:
  UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl- meso-diaminopimelate by linking it to UDP-N-acetylmuramate. Belongs to the MurCDEF family. Mpl subfamily.


ensembl_gene_id: HALO2123
symbol: ubiX
gene_biotype: protein_coding
description:
  Putative aromatic acid decarboxylase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family.


ensembl_gene_id: HALO2128
symbol: proA
gene_biotype: protein_coding
description:
  Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family.


ensembl_gene_id: HALO2129
symbol: nadD
gene_biotype: protein_coding
description:
  Putative nicotinate mononucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).


ensembl_gene_id: HALO2130
symbol: rsfS
gene_biotype: protein_coding
description:
  Ribosomal silencing factor RsfS; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.


ensembl_gene_id: HALO2131
symbol: rlmH
gene_biotype: protein_coding
description:
  Ribosomal RNA large subunit methyltransferase RlmH; Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA; Belongs to the RNA methyltransferase RlmH family.


ensembl_gene_id: HALO2132
symbol: mrdA
gene_biotype: protein_coding
description:
  Penicillin-binding protein 2; Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily.


ensembl_gene_id: HALO2133
symbol: mrdB
gene_biotype: protein_coding
description:
  Rod shape-determining protein RodA; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily.


ensembl_gene_id: HALO2135
symbol: rlpA
gene_biotype: protein_coding
description:
  RlpA-like lipoprotein; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.


ensembl_gene_id: HALO2138
symbol: lipB
gene_biotype: protein_coding
description:
  Lipoate-protein ligase B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.


ensembl_gene_id: HALO2139
symbol: lipA
gene_biotype: protein_coding
description:
  Lipoyl synthase-Sulfur insertion protein LipA; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.


ensembl_gene_id: HALO2142
symbol: topA
gene_biotype: protein_coding
description:
  DNA topoisomerase 1; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]


ensembl_gene_id: HALO2148
symbol: mfd
gene_biotype: protein_coding
description:
  Transcription-repair-coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily.


ensembl_gene_id: HALO2149
symbol: HALO2149
gene_biotype: protein_coding
description:
  Glyceraldehyde-3-phosphate dehydrogenase, type I; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.


ensembl_gene_id: HALO2150
symbol: nqrA
gene_biotype: protein_coding
description:
  Na(+)-translocating NADH-quinone reductase subunit A; NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.


ensembl_gene_id: HALO2151
symbol: nqrB
gene_biotype: protein_coding
description:
  Na(+)-translocating NADH-quinone reductase subunit B; NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.


ensembl_gene_id: HALO2152
symbol: nqrC
gene_biotype: protein_coding
description:
  Na(+)-translocating NADH-quinone reductase subunit C; NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.


ensembl_gene_id: HALO2153
symbol: nqrD
gene_biotype: protein_coding
description:
  Na(+)-translocating NADH-quinone reductase subunit D; NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol; Belongs to the NqrDE/RnfAE family.


ensembl_gene_id: HALO2154
symbol: nqrE
gene_biotype: protein_coding
description:
  Na(+)-translocating NADH-quinone reductase subunit E; NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol; Belongs to the NqrDE/RnfAE family.


ensembl_gene_id: HALO2155
symbol: nqrF
gene_biotype: protein_coding
description:
  Na(+)-translocating NADH-quinone reductase subunit F; NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway.


ensembl_gene_id: HALO2157
symbol: sthA
gene_biotype: protein_coding
description:
  Soluble pyridine nucleotide transhydrogenase; Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.


ensembl_gene_id: HALO2164
symbol: leuS
gene_biotype: protein_coding
description:
  Leucine--tRNA ligase-Leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.


ensembl_gene_id: HALO2182
symbol: rlmF
gene_biotype: protein_coding
description:
  Ribosomal RNA large subunit methyltransferase F; Specifically methylates the adenine in position 1618 of 23S rRNA.


ensembl_gene_id: HALO2195
symbol: leuC
gene_biotype: protein_coding
description:
  3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.


ensembl_gene_id: HALO2196
symbol: leuD
gene_biotype: protein_coding
description:
  3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.


ensembl_gene_id: HALO2197
symbol: leuB
gene_biotype: protein_coding
description:
  3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.


ensembl_gene_id: HALO2198
symbol: asd
gene_biotype: protein_coding
description:
  Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family.


ensembl_gene_id: HALO2200
symbol: truA
gene_biotype: protein_coding
description:
  tRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.


ensembl_gene_id: HALO2204
symbol: accD
gene_biotype: protein_coding
description:
  Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family.


ensembl_gene_id: HALO2208
symbol: purF
gene_biotype: protein_coding
description:
  Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.


ensembl_gene_id: HALO2209
symbol: metZ
gene_biotype: protein_coding
description:
  O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide.


ensembl_gene_id: HALO2220
symbol: HALO2220
gene_biotype: protein_coding
description:
  ATPase-like, ParA/MinD; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family.


ensembl_gene_id: HALO2222
symbol: purN
gene_biotype: protein_coding
description:
  Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.


ensembl_gene_id: HALO2227
symbol: fumC
gene_biotype: protein_coding
description:
  Fumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.


ensembl_gene_id: HALO2232
symbol: metN
gene_biotype: protein_coding
description:
  Methionine import ATP-binding protein MetN; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system.


ensembl_gene_id: HALO2235
symbol: apt
gene_biotype: protein_coding
description:
  Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.


ensembl_gene_id: HALO2236
symbol: gpt
gene_biotype: protein_coding
description:
  Xanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily.


ensembl_gene_id: HALO2237
symbol: ung
gene_biotype: protein_coding
description:
  Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.


ensembl_gene_id: HALO2238
symbol: upp
gene_biotype: protein_coding
description:
  Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate.


ensembl_gene_id: HALO2241
symbol: moaC
gene_biotype: protein_coding
description:
  Molybdenum cofactor biosynthesis protein C; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family.


ensembl_gene_id: HALO2246
symbol: lexA
gene_biotype: protein_coding
description:
  LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.


ensembl_gene_id: HALO2249
symbol: nagZ
gene_biotype: protein_coding
description:
  Beta-hexosaminidase; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.


ensembl_gene_id: HALO2251
symbol: HALO2251
gene_biotype: protein_coding
description:
  Putative phosphoenolpyruvate synthase regulatory protein; Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation.


ensembl_gene_id: HALO2252
symbol: HALO2252
gene_biotype: protein_coding
description:
  Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family.


ensembl_gene_id: HALO2255
symbol: HALO2255
gene_biotype: protein_coding
description:
  Regulator of ribonuclease activity A; Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions.


ensembl_gene_id: HALO2261
symbol: queE
gene_biotype: protein_coding
description:
  7-carboxy-7-deazaguanine synthase; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.


ensembl_gene_id: HALO2262
symbol: queC
gene_biotype: protein_coding
description:
  7-cyano-7-deazaguanine synthase; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family.


ensembl_gene_id: HALO2269
symbol: rhlE
gene_biotype: protein_coding
description:
  ATP-dependent RNA helicase rhlE; DEAD-box RNA helicase involved in ribosome assembly. Has RNA- dependent ATPase activity and unwinds double-stranded RNA.


ensembl_gene_id: HALO2279
symbol: HALO2279
gene_biotype: protein_coding
description:
  Adenine deaminase; Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism.


ensembl_gene_id: HALO2280
symbol: HALO2280
gene_biotype: protein_coding
description:
  Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.


ensembl_gene_id: HALO2288
symbol: HALO2288
gene_biotype: protein_coding
description:
  Cytochrome c oxidase subunit 2; Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).


ensembl_gene_id: HALO2289
symbol: HALO2289
gene_biotype: protein_coding
description:
  Cytochrome c oxidase, subunit I bacterial type; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.


ensembl_gene_id: HALO2296
symbol: cyoE
gene_biotype: protein_coding
description:
  Protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.


ensembl_gene_id: HALO2300
symbol: thrS
gene_biotype: protein_coding
description:
  Threonine--tRNA ligase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).


ensembl_gene_id: HALO2301
symbol: infC
gene_biotype: protein_coding
description:
  Translation initiation factor IF-3; IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.


ensembl_gene_id: HALO2303
symbol: rplT
gene_biotype: protein_coding
description:
  50S ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.


ensembl_gene_id: HALO2304
symbol: pheS
gene_biotype: protein_coding
description:
  Phenylalanine--tRNA ligase alpha subunit; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.


ensembl_gene_id: HALO2305
symbol: pheT
gene_biotype: protein_coding
description:
  Phenylalanine--tRNA ligase beta subunit; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.


ensembl_gene_id: HALO2306
symbol: ihfA
gene_biotype: protein_coding
description:
  Integration host factor subunit alpha; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family.


ensembl_gene_id: HALO2310
symbol: tig
gene_biotype: protein_coding
description:
  Trigger factor-PPIase; Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belongs to the FKBP-type PPIase family. Tig subfamily.


ensembl_gene_id: HALO2311
symbol: clpP
gene_biotype: protein_coding
description:
  ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.


ensembl_gene_id: HALO2312
symbol: clpX
gene_biotype: protein_coding
description:
  ATP-dependent Clp protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.


ensembl_gene_id: HALO2313
symbol: lon
gene_biotype: protein_coding
description:
  Lon protease-ATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.


ensembl_gene_id: HALO2314
symbol: HALO2314
gene_biotype: protein_coding
description:
  DNA-binding protein HU-beta; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.


ensembl_gene_id: HALO2316
symbol: lpxH
gene_biotype: protein_coding
description:
  UDP-2,3-diacylglucosamine hydrolase; Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.


ensembl_gene_id: HALO2317
symbol: HALO2317
gene_biotype: protein_coding
description:
  Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.


ensembl_gene_id: HALO2324
symbol: HALO2324
gene_biotype: protein_coding
description:
  2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).


ensembl_gene_id: HALO2345
symbol: HALO2345
gene_biotype: protein_coding
description:
  3-hydroxyacyl-CoA dehydrogenase NAD-binding protein; Belongs to the enoyl-CoA hydratase/isomerase family.


ensembl_gene_id: HALO2354
symbol: HALO2354
gene_biotype: protein_coding
description:
  Putative fused oligopeptide transporter subunits of ABC superfamily: ATP-binding components; Belongs to the ABC transporter superfamily.


ensembl_gene_id: HALO2359
symbol: gloB
gene_biotype: protein_coding
description:
  Hydroxyacylglutathione hydrolase-Glyoxalase II; Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl- glutathione to form glutathione and D-lactic acid.


ensembl_gene_id: HALO2362
symbol: dnaQ
gene_biotype: protein_coding
description:
  DNA polymerase III subunit epsilon; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease.


ensembl_gene_id: HALO2368
symbol: HALO2368
gene_biotype: protein_coding
description:
  Putative uncharacterized protein; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.


ensembl_gene_id: HALO2436
symbol: HALO2436
gene_biotype: protein_coding
description:
  ABC ribose transporter permease component; Belongs to the binding-protein-dependent transport system permease family.


ensembl_gene_id: HALO2438
symbol: rbsA
gene_biotype: protein_coding
description:
  Sugar ABC transporter ATP-binding protein; Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Ribose importer (TC 3.A.1.2.1) family.


ensembl_gene_id: HALO2470
symbol: pdxH
gene_biotype: protein_coding
description:
  Pyridoxine/pyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).


ensembl_gene_id: HALO2479
symbol: HALO2479
gene_biotype: protein_coding
description:
  Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.


ensembl_gene_id: HALO2480
symbol: nfuA
gene_biotype: protein_coding
description:
  Fe/S biogenesis protein NfuA; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins.


ensembl_gene_id: HALO2484
symbol: hisI
gene_biotype: protein_coding
description:
  Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.


ensembl_gene_id: HALO2490
symbol: ectC
gene_biotype: protein_coding
description:
  Ectoine synthase; Catalyzes the circularization of gamma-N-acetyl-alpha,gamma- diaminobutyric acid (ADABA) to ectoine (1,4,5,6-tetrahydro-2-methyl-4- pyrimidine carboxylic acid), which is an excellent osmoprotectant.


ensembl_gene_id: HALO2491
symbol: HALO2491
gene_biotype: protein_coding
description:
  Diaminobutyrate--2-oxoglutarate transaminase; Catalyzes reversively the conversion of L-aspartate beta- semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.


ensembl_gene_id: HALO2492
symbol: ectA
gene_biotype: protein_coding
description:
  L-2,4-diaminobutyric acid acetyltransferase; Catalyzes the acetylation of L-2,4-diaminobutyrate (DABA) to gamma-N-acetyl-alpha,gamma-diaminobutyric acid (ADABA) with acetyl coenzyme A.


ensembl_gene_id: HALO2494
symbol: HALO2494
gene_biotype: protein_coding
description:
  Carbonic anhydrase 2; Reversible hydration of carbon dioxide. Belongs to the beta-class carbonic anhydrase family.


ensembl_gene_id: HALO2496
symbol: msrA-2
gene_biotype: protein_coding
description:
  Peptide methionine sulfoxide reductase MsrA; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.


ensembl_gene_id: HALO2503
symbol: ubiG
gene_biotype: protein_coding
description:
  Ubiquinone biosynthesis O-methyltransferase; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the methyltransferase superfamily. UbiG/COQ3 family.


ensembl_gene_id: HALO2506
symbol: cpoB
gene_biotype: protein_coding
description:
  Tol-Pal system, YbgF; Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division; Belongs to the CpoB family.


ensembl_gene_id: HALO2507
symbol: pal
gene_biotype: protein_coding
description:
  Peptidoglycan-associated lipoprotein; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.


ensembl_gene_id: HALO2508
symbol: tolB
gene_biotype: protein_coding
description:
  Protein TolB; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.


ensembl_gene_id: HALO2510
symbol: tolR
gene_biotype: protein_coding
description:
  Protein tolR; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.


ensembl_gene_id: HALO2511
symbol: tolQ
gene_biotype: protein_coding
description:
  Tol-Pal system, TolQ; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.


ensembl_gene_id: HALO2513
symbol: ruvB
gene_biotype: protein_coding
description:
  Holliday junction ATP-dependent DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.


ensembl_gene_id: HALO2514
symbol: ruvA
gene_biotype: protein_coding
description:
  Holliday junction ATP-dependent DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.


ensembl_gene_id: HALO2515
symbol: ruvC
gene_biotype: protein_coding
description:
  Holliday junction ATP-dependent DNA helicase RuvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.


ensembl_gene_id: HALO2516
symbol: aspS
gene_biotype: protein_coding
description:
  Aspartate--tRNA ligase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.


ensembl_gene_id: HALO2518
symbol: HALO2518
gene_biotype: protein_coding
description:
  Putative 2-hydroxyacid dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.


ensembl_gene_id: HALO2523
symbol: HALO2523
gene_biotype: protein_coding
description:
  Phospholipase D/Transphosphatidylase; Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol; Belongs to the phospholipase D family. Cardiolipin synthase subfamily.


ensembl_gene_id: HALO2524
symbol: HALO2524
gene_biotype: protein_coding
description:
  Fumarate hydratase, class I; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.


ensembl_gene_id: HALO2526
symbol: uvrB
gene_biotype: protein_coding
description:
  UvrABC system protein B-Excinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the U [...]


ensembl_gene_id: HALO2531
symbol: prfC
gene_biotype: protein_coding
description:
  Peptide chain release factor 3; Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.


ensembl_gene_id: HALO2535
symbol: folD
gene_biotype: protein_coding
description:
  Bifunctional protein FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.


ensembl_gene_id: HALO2536
symbol: mtnN
gene_biotype: protein_coding
description:
  5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.


ensembl_gene_id: HALO2553
symbol: gcvH
gene_biotype: protein_coding
description:
  Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.


ensembl_gene_id: HALO2554
symbol: gcvP
gene_biotype: protein_coding
description:
  Glycine dehydrogenase [decarboxylating]; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.


ensembl_gene_id: HALO2563
symbol: moaA
gene_biotype: protein_coding
description:
  Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate.


ensembl_gene_id: HALO2571
symbol: HALO2571
gene_biotype: protein_coding
description:
  Respiratory nitrate reductase 1 alpha chain NarG; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.


ensembl_gene_id: HALO2580
symbol: HALO2580
gene_biotype: protein_coding
description:
  Nitrate/nitrite response regulator protein NarL,response regulator in two-component regulatory system.


ensembl_gene_id: HALO2589
symbol: HALO2589
gene_biotype: protein_coding
description:
  Type 4 prepilin-like proteins leader peptide-processing enzyme; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue.


ensembl_gene_id: HALO2590
symbol: coaE
gene_biotype: protein_coding
description:
  Dephospho-CoA kinase-Dephosphocoenzyme A kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family.


ensembl_gene_id: HALO2591
symbol: yacG
gene_biotype: protein_coding
description:
  DNA gyrase inhibitor YacG; Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C- terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.


ensembl_gene_id: HALO2596
symbol: HALO2596
gene_biotype: protein_coding
description:
  30S ribosomal protein S1; Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence.


ensembl_gene_id: HALO2598
symbol: aroA
gene_biotype: protein_coding
description:
  3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.


ensembl_gene_id: HALO2600
symbol: serC
gene_biotype: protein_coding
description:
  Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.


ensembl_gene_id: HALO2601
symbol: gyrA
gene_biotype: protein_coding
description:
  DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.


ensembl_gene_id: HALO2603
symbol: HALO2603
gene_biotype: protein_coding
description:
  Recombination-associated protein rdgC; May be involved in recombination. Belongs to the RdgC family.


ensembl_gene_id: HALO2606
symbol: metG
gene_biotype: protein_coding
description:
  Methionine--tRNA ligase-Methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.


ensembl_gene_id: HALO2607
symbol: rnfA
gene_biotype: protein_coding
description:
  Electron transport complex, RnfA; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.


ensembl_gene_id: HALO2608
symbol: rnfB
gene_biotype: protein_coding
description:
  Putative iron-sulfur protein; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.


ensembl_gene_id: HALO2609
symbol: rnfC
gene_biotype: protein_coding
description:
  Electron transport complex protein rnfC; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.


ensembl_gene_id: HALO2610
symbol: rnfD
gene_biotype: protein_coding
description:
  Electron transport complex, RnfD; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the NqrB/RnfD family.


ensembl_gene_id: HALO2611
symbol: rnfG
gene_biotype: protein_coding
description:
  Electron transport complex protein rnfG; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the RnfG family.


ensembl_gene_id: HALO2612
symbol: rnfE
gene_biotype: protein_coding
description:
  Electron transport complex, RnfE; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.


ensembl_gene_id: HALO2613
symbol: nth
gene_biotype: protein_coding
description:
  Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.


ensembl_gene_id: HALO2624
symbol: rnt
gene_biotype: protein_coding
description:
  Ribonuclease T-Exoribonuclease T; Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis.


ensembl_gene_id: HALO2625
symbol: pfp
gene_biotype: protein_coding
description:
  Phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.


ensembl_gene_id: HALO2627
symbol: ppa
gene_biotype: protein_coding
description:
  Inorganic pyrophosphatase; Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.


ensembl_gene_id: HALO2628
symbol: dsbD-2
gene_biotype: protein_coding
description:
  Thiol:disulfide interchange protein DsbD; Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps. Belongs to the thioredoxin family. DsbD subfamily.


ensembl_gene_id: HALO2629
symbol: HALO2629
gene_biotype: protein_coding
description:
  Biotin carboxyl carrier protein of acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.


ensembl_gene_id: HALO2630
symbol: HALO2630
gene_biotype: protein_coding
description:
  Biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.


ensembl_gene_id: HALO2631
symbol: prmA
gene_biotype: protein_coding
description:
  Ribosomal protein L11 methyltransferase; Methylates ribosomal protein L11; Belongs to the methyltransferase superfamily. PrmA family.


ensembl_gene_id: HALO2632
symbol: dusB
gene_biotype: protein_coding
description:
  tRNA-dihydrouridine synthase; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the Dus family. DusB subfamily.


ensembl_gene_id: HALO2633
symbol: HALO2633
gene_biotype: protein_coding
description:
  DNA-binding protein fi; Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters; Belongs to the transcriptional regulatory Fis family.


ensembl_gene_id: HALO2638
symbol: srkA
gene_biotype: protein_coding
description:
  Aminoglycoside phosphotransferase; A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response.


ensembl_gene_id: HALO2645
symbol: groS
gene_biotype: protein_coding
description:
  10 kDa chaperonin; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.


ensembl_gene_id: HALO2646
symbol: groL
gene_biotype: protein_coding
description:
  60 kDa chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.


ensembl_gene_id: HALO2649
symbol: trmJ
gene_biotype: protein_coding
description:
  tRNA (Cytidine/uridine-2'-O-)-methyltransferase TrmJ; Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA.


ensembl_gene_id: HALO2654
symbol: HALO2654
gene_biotype: protein_coding
description:
  Putative potassium efflux transporter; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family.


ensembl_gene_id: HALO2675
symbol: HALO2675
gene_biotype: protein_coding
description:
  Phosphotyrosine protein phosphatase I superfamily; Belongs to the low molecular weight phosphotyrosine protein phosphatase family.


ensembl_gene_id: HALO2696
symbol: atpD
gene_biotype: protein_coding
description:
  ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.


ensembl_gene_id: HALO2697
symbol: atpC
gene_biotype: protein_coding
description:
  ATP synthase epsilon chain; Produces ATP from ADP in the presence of a proton gradient across the membrane.


ensembl_gene_id: HALO2700
symbol: atpB
gene_biotype: protein_coding
description:
  ATP synthase subunit A; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. Belongs to the ATPase A chain family.


ensembl_gene_id: HALO2701
symbol: atpE
gene_biotype: protein_coding
description:
  H+-transporting two-sector ATPase, C subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.


ensembl_gene_id: HALO2702
symbol: atpF
gene_biotype: protein_coding
description:
  ATP synthase subunit B; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family.


ensembl_gene_id: HALO2703
symbol: atpA
gene_biotype: protein_coding
description:
  ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.


ensembl_gene_id: HALO2719
symbol: ackA
gene_biotype: protein_coding
description:
  Acetate kinase-Acetokinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family.


ensembl_gene_id: HALO2728
symbol: betB
gene_biotype: protein_coding
description:
  NAD/NADP-dependent betaine aldehyde dehydrogenase; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid.


ensembl_gene_id: HALO2729
symbol: betA
gene_biotype: protein_coding
description:
  Oxygen-dependent choline dehydrogenase; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.


ensembl_gene_id: HALO2731
symbol: HALO2731
gene_biotype: protein_coding
description:
  Sn-glycerol-3-phosphate import ATP-binding protein UgpC 1; Belongs to the ABC transporter superfamily.


ensembl_gene_id: HALO2732
symbol: HALO2732
gene_biotype: protein_coding
description:
  Sn-glycerol-3-phosphate import ATP-binding protein UgpC; Belongs to the ABC transporter superfamily.


ensembl_gene_id: HALO2739
symbol: glpK
gene_biotype: protein_coding
description:
  Glycerol kinase-ATP:glycerol 3-phosphotransferase-Glycerokinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family.


ensembl_gene_id: HALO2747
symbol: nfo
gene_biotype: protein_coding
description:
  Endodeoxyribonuclease IV; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin.


ensembl_gene_id: HALO2750
symbol: proS
gene_biotype: protein_coding
description:
  Proline--tRNA ligase-Prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' edi [...]


ensembl_gene_id: HALO2783
symbol: kynA
gene_biotype: protein_coding
description:
  Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.


ensembl_gene_id: HALO2784
symbol: kynU
gene_biotype: protein_coding
description:
  Kynureninase-L-kynurenine hydrolase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively.


ensembl_gene_id: HALO2790
symbol: map
gene_biotype: protein_coding
description:
  Methionine aminopeptidase-Peptidase M; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.


ensembl_gene_id: HALO2817
symbol: HALO2817
gene_biotype: protein_coding
description:
  2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.


ensembl_gene_id: HALO2822
symbol: HALO2822
gene_biotype: protein_coding
description:
  Branched-chain amino acid ABC transporter permease; Belongs to the binding-protein-dependent transport system permease family.


ensembl_gene_id: HALO2836
symbol: HALO2836
gene_biotype: protein_coding
description:
  K+/H+ exchanger; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family.


ensembl_gene_id: HALO2842
symbol: ppc
gene_biotype: protein_coding
description:
  Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family.


ensembl_gene_id: HALO2844
symbol: HALO2844
gene_biotype: protein_coding
description:
  GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.


ensembl_gene_id: HALO2845
symbol: rlmD
gene_biotype: protein_coding
description:
  23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD; Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily.


ensembl_gene_id: HALO2848
symbol: acpS
gene_biotype: protein_coding
description:
  Holo-[acyl-carrier-protein] synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family.


ensembl_gene_id: HALO2849
symbol: pdxJ
gene_biotype: protein_coding
description:
  Pyridoxine 5'-phosphate synthase; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.


ensembl_gene_id: HALO2851
symbol: era
gene_biotype: protein_coding
description:
  GTPase Era; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.


ensembl_gene_id: HALO2852
symbol: rnc
gene_biotype: protein_coding
description:
  Ribonuclease III; Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.


ensembl_gene_id: HALO2854
symbol: lepA
gene_biotype: protein_coding
description:
  Elongation factor 4; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner.


ensembl_gene_id: HALO2860
symbol: HALO2860
gene_biotype: protein_coding
description:
  Phospho-2-dehydro-3-deoxyheptonate aldolase, Tyr-sensitive; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP).


ensembl_gene_id: HALO2862
symbol: rhlB
gene_biotype: protein_coding
description:
  ATP-dependent RNA helicase RhlB; DEAD-box RNA helicase involved in RNA degradation. Has RNA- dependent ATPase activity and unwinds double-stranded RNA. Belongs to the DEAD box helicase family. RhlB subfamily.


ensembl_gene_id: HALO2866
symbol: HALO2866
gene_biotype: protein_coding
description:
  Putative uncharacterized protein; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Belongs to the TonB family.


ensembl_gene_id: HALO2872
symbol: HALO2872
gene_biotype: protein_coding
description:
  Ribonucleoside-diphosphate reductase subunit beta; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family.


ensembl_gene_id: HALO2873
symbol: HALO2873
gene_biotype: protein_coding
description:
  Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.


ensembl_gene_id: HALO2876
symbol: HALO2876
gene_biotype: protein_coding
description:
  Superoxide dismutase (Mn); Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.


ensembl_gene_id: HALO2879
symbol: HALO2879
gene_biotype: protein_coding
description:
  Electron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone.


ensembl_gene_id: HALO2888
symbol: tmk
gene_biotype: protein_coding
description:
  Thymidylate kinase-dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.


ensembl_gene_id: HALO2889
symbol: mltG
gene_biotype: protein_coding
description:
  UPF0755 protein; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.


ensembl_gene_id: HALO2893
symbol: HALO2893
gene_biotype: protein_coding
description:
  3-oxoacyl-(Acyl-carrier-protein) reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family.


ensembl_gene_id: HALO2895
symbol: plsX
gene_biotype: protein_coding
description:
  Phosphate acyltransferase; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.


ensembl_gene_id: HALO2898
symbol: HALO2898
gene_biotype: protein_coding
description:
  Maf-like protein HALA3H3_950023; Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.


ensembl_gene_id: HALO2902
symbol: rne
gene_biotype: protein_coding
description:
  Ribonuclease E; Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs. Belongs to the RNase E/G family. RNase E subfamily.


ensembl_gene_id: HALO2905
symbol: kdsB
gene_biotype: protein_coding
description:
  3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.


ensembl_gene_id: HALO2907
symbol: lpxK
gene_biotype: protein_coding
description:
  Tetraacyldisaccharide 4'-kinase-Lipid A 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).


ensembl_gene_id: HALO2908
symbol: msbA
gene_biotype: protein_coding
description:
  Lipid A export ATP-binding/permease protein MsbA; Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.


ensembl_gene_id: HALO2911
symbol: lolD
gene_biotype: protein_coding
description:
  Lipoprotein-releasing system ATP-binding protein LolD; Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner. Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family.


ensembl_gene_id: HALO2916
symbol: argJ
gene_biotype: protein_coding
description:
  Arginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family.


ensembl_gene_id: HALO2917
symbol: secA
gene_biotype: protein_coding
description:
  Protein translocase subunit SecA; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. Belongs to the SecA family.


ensembl_gene_id: HALO2919
symbol: lpxC
gene_biotype: protein_coding
description:
  UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family.


ensembl_gene_id: HALO2920
symbol: ftsZ
gene_biotype: protein_coding
description:
  Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.


ensembl_gene_id: HALO2921
symbol: ftsA
gene_biotype: protein_coding
description:
  Cell division protein FtsA; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family.


ensembl_gene_id: HALO2922
symbol: ftsQ
gene_biotype: protein_coding
description:
  Cell division protein FtsQ; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly.


ensembl_gene_id: HALO2923
symbol: ddl
gene_biotype: protein_coding
description:
  D-alanine--D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family.


ensembl_gene_id: HALO2925
symbol: murG
gene_biotype: protein_coding
description:
  Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily.


ensembl_gene_id: HALO2926
symbol: ftsW
gene_biotype: protein_coding
description:
  Cell division protein FtsW; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily.


ensembl_gene_id: HALO2927
symbol: murD
gene_biotype: protein_coding
description:
  UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family.


ensembl_gene_id: HALO2928
symbol: mraY
gene_biotype: protein_coding
description:
  Phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily.


ensembl_gene_id: HALO2929
symbol: murF
gene_biotype: protein_coding
description:
  UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily.


ensembl_gene_id: HALO2930
symbol: murE
gene_biotype: protein_coding
description:
  UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily.


ensembl_gene_id: HALO2931
symbol: ftsI
gene_biotype: protein_coding
description:
  Peptidoglycan synthase FtsI; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum; Belongs to the transpeptidase family. FtsI subfamily.


ensembl_gene_id: HALO2932
symbol: ftsL
gene_biotype: protein_coding
description:
  Cell division protein FtsL; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.


ensembl_gene_id: HALO2933
symbol: rsmH
gene_biotype: protein_coding
description:
  Ribosomal RNA small subunit methyltransferase RsmH; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.


ensembl_gene_id: HALO2934
symbol: rsmI
gene_biotype: protein_coding
description:
  Ribosomal RNA small subunit methyltransferase RsmI; Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.


ensembl_gene_id: HALO2937
symbol: gmhA
gene_biotype: protein_coding
description:
  Phosphoheptose isomerase; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.


ensembl_gene_id: HALO2942
symbol: HALO2942
gene_biotype: protein_coding
description:
  Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.


ensembl_gene_id: HALO2943
symbol: HALO2943
gene_biotype: protein_coding
description:
  Ubiquinol-cytochrome c reductase iron-sulfur subunit; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.


ensembl_gene_id: HALO2945
symbol: rplM
gene_biotype: protein_coding
description:
  50S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.


ensembl_gene_id: HALO2950
symbol: hisD
gene_biotype: protein_coding
description:
  Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.


ensembl_gene_id: HALO2951
symbol: hisG
gene_biotype: protein_coding
description:
  ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily.


ensembl_gene_id: HALO2952
symbol: murA
gene_biotype: protein_coding
description:
  UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily.


ensembl_gene_id: HALO2960
symbol: HALO2960
gene_biotype: protein_coding
description:
  3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8- phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate; Belongs to the KdsC family.


ensembl_gene_id: HALO2962
symbol: lptA
gene_biotype: protein_coding
description:
  Lipopolysccharide assembly, LptA; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm.


ensembl_gene_id: HALO2964
symbol: HALO2964
gene_biotype: protein_coding
description:
  RNA polymerase sigma-54 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.


ensembl_gene_id: HALO2974
symbol: HALO2974
gene_biotype: protein_coding
description:
  Maf-like protein yhdE; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.


ensembl_gene_id: HALO2975
symbol: HALO2975
gene_biotype: protein_coding
description:
  Rod shape-determining protein mreD; Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins. Belongs to the MreD family.


ensembl_gene_id: HALO2976
symbol: HALO2976
gene_biotype: protein_coding
description:
  Cell shape-determining protein MreC-Cell shape protein MreC; Involved in formation and maintenance of cell shape.


ensembl_gene_id: HALO2978
symbol: gatC
gene_biotype: protein_coding
description:
  Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatC family.


ensembl_gene_id: HALO2979
symbol: gatA
gene_biotype: protein_coding
description:
  Glutamyl-tRNA(Gln) amidotransferase subunit A; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln).


ensembl_gene_id: HALO2980
symbol: gatB
gene_biotype: protein_coding
description:
  Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily.


ensembl_gene_id: HALO2982
symbol: gpsA
gene_biotype: protein_coding
description:
  Glycerol-3-phosphate dehydrogenase [NAD(P)+]; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.


ensembl_gene_id: HALO2989
symbol: HALO2989
gene_biotype: protein_coding
description:
  Diacylglycerol/lipid kinase; Probably phosphorylates lipids; the in vivo substrate is unknown; Belongs to the diacylglycerol/lipid kinase family. YegS lipid kinase subfamily.


ensembl_gene_id: HALO2993
symbol: purA
gene_biotype: protein_coding
description:
  Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.


ensembl_gene_id: HALO2994
symbol: hisZ
gene_biotype: protein_coding
description:
  ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.


ensembl_gene_id: HALO2997
symbol: hflX
gene_biotype: protein_coding
description:
  GTP-binding protein HflX; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.


ensembl_gene_id: HALO2998
symbol: hfq
gene_biotype: protein_coding
description:
  RNA-binding protein Hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family.


ensembl_gene_id: HALO2999
symbol: miaA
gene_biotype: protein_coding
description:
  tRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family.


ensembl_gene_id: HALO3000
symbol: mutL
gene_biotype: protein_coding
description:
  DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.


ensembl_gene_id: HALO3003
symbol: nnrE
gene_biotype: protein_coding
description:
  Putative carbohydrate kinase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.  Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of  [...]


ensembl_gene_id: HALO3004
symbol: queG
gene_biotype: protein_coding
description:
  Epoxyqueuosine reductase; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr); Belongs to the QueG family.


ensembl_gene_id: HALO3005
symbol: orn
gene_biotype: protein_coding
description:
  Oligoribonuclease; 3'-to-5' exoribonuclease specific for small oligoribonucleotides; Belongs to the oligoribonuclease family.


ensembl_gene_id: HALO3006
symbol: rsgA
gene_biotype: protein_coding
description:
  Putative ribosome biogenesis GTPase RsgA; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.


ensembl_gene_id: HALO3008
symbol: psd
gene_biotype: protein_coding
description:
  Phosphatidylserine decarboxylase proenzyme; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).


ensembl_gene_id: HALO3013
symbol: efp
gene_biotype: protein_coding
description:
  Elongation factor P; Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation; Belongs to the elongation factor P family.


ensembl_gene_id: HALO3038
symbol: parC
gene_biotype: protein_coding
description:
  DNA topoisomerase IV, subunit A, Gram-negative; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily.


ensembl_gene_id: HALO3040
symbol: parE
gene_biotype: protein_coding
description:
  DNA topoisomerase 4 subunit B; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 1 subfamily.


ensembl_gene_id: HALO3042
symbol: HALO3042
gene_biotype: protein_coding
description:
  tRNA (cmo5U34)-methyltransferase; Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM).


ensembl_gene_id: HALO3043
symbol: cmoB
gene_biotype: protein_coding
description:
  Putative uncharacterized protein; Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L- methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5- carboxymethoxyuridine (cmo5U) at position 34 in tRNAs.


ensembl_gene_id: HALO3056
symbol: cysN
gene_biotype: protein_coding
description:
  Sulfate adenylyltransferase subunit 1; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily.


ensembl_gene_id: HALO3062
symbol: greB
gene_biotype: protein_coding
description:
  Transcription elongation factor GreB; Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length.


ensembl_gene_id: HALO3065
symbol: cmoM
gene_biotype: protein_coding
description:
  Protein smtA; Catalyzes the methylation of 5-carboxymethoxyuridine (cmo5U) to form 5-methoxycarbonylmethoxyuridine (mcmo5U) at position 34 in tRNAs; Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoM family.


ensembl_gene_id: HALO3070
symbol: HALO3070
gene_biotype: protein_coding
description:
  2-oxo-carboxylic acid reductase (Glyoxalate reductase) (2-ketoaldonate reductase); Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.


ensembl_gene_id: HALO3093
symbol: hutU
gene_biotype: protein_coding
description:
  Imidazolonepropionate hydrolase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate.


ensembl_gene_id: HALO3116
symbol: hisC-2
gene_biotype: protein_coding
description:
  Imidazole acetol-phosphate transaminase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.


ensembl_gene_id: HALO3119
symbol: lcdH
gene_biotype: protein_coding
description:
  L-carnitine dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-carnitine to 3- dehydrocarnitine.


ensembl_gene_id: HALO3177
symbol: rfaH
gene_biotype: protein_coding
description:
  Transcription antitermination protein nusG; Enhances distal genes transcription elongation in a specialized subset of operons that encode extracytoplasmic components. Belongs to the RfaH family.


ensembl_gene_id: HALO3185
symbol: cysQ
gene_biotype: protein_coding
description:
  3'(2'),5'-bisphosphate nucleotidase; Converts adenosine-3',5'-bisphosphate (PAP) to AMP. Belongs to the inositol monophosphatase superfamily. CysQ family.


ensembl_gene_id: HALO3204
symbol: HALO3204
gene_biotype: protein_coding
description:
  dTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.


ensembl_gene_id: HALO3205
symbol: HALO3205
gene_biotype: protein_coding
description:
  Glucose-1-phosphate thymidylyltransferase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family.


ensembl_gene_id: HALO3206
symbol: HALO3206
gene_biotype: protein_coding
description:
  dTDP-4-dehydrorhamnose reductase subunit,NAD(P)-binding, of dTDP-L-rhamnose synthase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose; Belongs to the dTDP-4-dehydrorhamnose reductase family.


ensembl_gene_id: HALO3208
symbol: HALO3208
gene_biotype: protein_coding
description:
  dTDP-glucose 4,6-dehydratase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.


ensembl_gene_id: HALO3220
symbol: HALO3220
gene_biotype: protein_coding
description:
  Protein proQ-like protein; RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities; Belongs to the ProQ family.


ensembl_gene_id: HALO3221
symbol: HALO3221
gene_biotype: protein_coding
description:
  Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.


ensembl_gene_id: HALO3222
symbol: thyA
gene_biotype: protein_coding
description:
  Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.


ensembl_gene_id: HALO3224
symbol: lgt
gene_biotype: protein_coding
description:
  Prolipoprotein diacylglyceryl transferase; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family.


ensembl_gene_id: HALO3228
symbol: rppH
gene_biotype: protein_coding
description:
  RNA pyrophosphohydrolase; Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily.


ensembl_gene_id: HALO3233
symbol: mdh
gene_biotype: protein_coding
description:
  Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family.


ensembl_gene_id: HALO3234
symbol: HALO3234
gene_biotype: protein_coding
description:
  Efflux transporter RND family, MFP subunit; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.


ensembl_gene_id: HALO3235
symbol: HALO3235
gene_biotype: protein_coding
description:
  Nodulation protein nolG; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.


ensembl_gene_id: HALO3251
symbol: dsbB
gene_biotype: protein_coding
description:
  Disulfide bond formation protein B-Disulfide oxidoreductase; Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein; Belongs to the DsbB family.


ensembl_gene_id: HALO3252
symbol: gshA
gene_biotype: protein_coding
description:
  Glutamate--cysteine ligase; Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily.


ensembl_gene_id: HALO3258
symbol: pckA
gene_biotype: protein_coding
description:
  Phosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.


ensembl_gene_id: HALO3259
symbol: hslO
gene_biotype: protein_coding
description:
  33 kDa chaperonin; Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.


ensembl_gene_id: HALO3270
symbol: thiL
gene_biotype: protein_coding
description:
  Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family.


ensembl_gene_id: HALO3271
symbol: nusB
gene_biotype: protein_coding
description:
  N utilization substance protein B homolog; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.


ensembl_gene_id: HALO3273
symbol: ribB
gene_biotype: protein_coding
description:
  3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family.


ensembl_gene_id: HALO3274
symbol: HALO3274
gene_biotype: protein_coding
description:
  Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.


ensembl_gene_id: HALO3275
symbol: nrdR
gene_biotype: protein_coding
description:
  Transcriptional repressor NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family.


ensembl_gene_id: HALO3314
symbol: queF
gene_biotype: protein_coding
description:
  NADPH-dependent 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).


ensembl_gene_id: HALO3319
symbol: HALO3319
gene_biotype: protein_coding
description:
  Extracellular solute-binding protein; Part of the tripartite ATP-independent periplasmic (TRAP) transport system.


ensembl_gene_id: HALO3324
symbol: HALO3324
gene_biotype: protein_coding
description:
  Ribosome biogenesis GTPase A; Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity; Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.


ensembl_gene_id: HALO3327
symbol: pdxB
gene_biotype: protein_coding
description:
  Erythronate-4-phosphate dehydrogenase; Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate.


ensembl_gene_id: HALO3330
symbol: rlmL
gene_biotype: protein_coding
description:
  Ribosomal RNA large subunit methyltransferase K/L; Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA. Belongs to the methyltransferase superfamily. RlmKL family.


ensembl_gene_id: HALO3331
symbol: rmf
gene_biotype: protein_coding
description:
  Ribosome modulation factor; During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes); Belongs to the ribosome modulation factor family.


ensembl_gene_id: HALO3332
symbol: pyrD
gene_biotype: protein_coding
description:
  Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.


ensembl_gene_id: HALO3334
symbol: trmA
gene_biotype: protein_coding
description:
  tRNA/tmRNA (uracil-C(5))-methyltransferase; Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA).


ensembl_gene_id: HALO3338
symbol: lolA
gene_biotype: protein_coding
description:
  Outer-membrane lipoprotein carrier protein; Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).


ensembl_gene_id: HALO3340
symbol: aat
gene_biotype: protein_coding
description:
  Leucyl/phenylalanyl-tRNA--protein transferase; Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl- tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.


ensembl_gene_id: HALO3341
symbol: bpt
gene_biotype: protein_coding
description:
  Putative arginyl-tRNA--protein transferase; Functions in the N-end rule pathway of protein degradation where it conjugates Leu from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate. Belongs to the R-transferase family. Bpt subfamily.


ensembl_gene_id: HALO3342
symbol: infA
gene_biotype: protein_coding
description:
  Translation initiation factor IF-1; One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.


ensembl_gene_id: HALO3344
symbol: clpS
gene_biotype: protein_coding
description:
  ATP-dependent Clp protease adapter protein ClpS; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family.


ensembl_gene_id: HALO3347
symbol: nudJ
gene_biotype: protein_coding
description:
  Bifunctional thiamin pyrimidine pyrophosphate hydrolase and thiamin pyrophosphate hydrolase; Belongs to the Nudix hydrolase family. NudJ subfamily.


ensembl_gene_id: HALO3348
symbol: mnmA
gene_biotype: protein_coding
description:
  tRNA-specific 2-thiouridylase MnmA; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.


ensembl_gene_id: HALO3357
symbol: HALO3357
gene_biotype: protein_coding
description:
  Putative nickel-responsive regulator; Transcriptional regulator; Belongs to the transcriptional regulatory CopG/NikR family.


ensembl_gene_id: HALO3367
symbol: HALO3367
gene_biotype: protein_coding
description:
  Glycoside hydrolase-type carbohydrate-binding, subgroup; Belongs to the glucose-6-phosphate 1-epimerase family.


ensembl_gene_id: HALO3384
symbol: rnb
gene_biotype: protein_coding
description:
  Exoribonuclease 2; Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction.


ensembl_gene_id: HALO3385
symbol: HALO3385
gene_biotype: protein_coding
description:
  dTDP-4-deoxyrhamnose-3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.


ensembl_gene_id: HALO3394
symbol: sucD
gene_biotype: protein_coding
description:
  Succinyl-CoA ligase [ADP-forming] subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.


ensembl_gene_id: HALO3395
symbol: sucC
gene_biotype: protein_coding
description:
  Succinyl-CoA ligase [ADP-forming] subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.


ensembl_gene_id: HALO3397
symbol: HALO3397
gene_biotype: protein_coding
description:
  Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2).


ensembl_gene_id: HALO3400
symbol: HALO3400
gene_biotype: protein_coding
description:
  Succinate dehydrogenase/fumarate reductase, flavoprotein sub; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.


ensembl_gene_id: HALO3401
symbol: HALO3401
gene_biotype: protein_coding
description:
  Succinate dehydrogenase hydrophobic membrane anchor subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH).


ensembl_gene_id: HALO3404
symbol: gltX
gene_biotype: protein_coding
description:
  Glutamate--tRNA ligase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.


ensembl_gene_id: HALO3417
symbol: dusA
gene_biotype: protein_coding
description:
  tRNA-dihydrouridine synthase; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs; Belongs to the Dus family. DusA subfamily.


ensembl_gene_id: HALO3428
symbol: cynS
gene_biotype: protein_coding
description:
  Cyanate hydratase; Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide; Belongs to the cyanase family.


ensembl_gene_id: HALO3430
symbol: tal
gene_biotype: protein_coding
description:
  Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.


ensembl_gene_id: HALO3478
symbol: HALO3478
gene_biotype: protein_coding
description:
  Glucans biosynthesis protein G; Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs).


ensembl_gene_id: HALO3481
symbol: ribA-2
gene_biotype: protein_coding
description:
  GTP cyclohydrolase-2; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family.


ensembl_gene_id: HALO3487
symbol: HALO3487
gene_biotype: protein_coding
description:
  Putative uncharacterized protein; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.


ensembl_gene_id: HALO3496
symbol: HALO3496
gene_biotype: protein_coding
description:
  Efflux pump periplasmic linker BepF; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.


ensembl_gene_id: HALO3498
symbol: mntP
gene_biotype: protein_coding
description:
  Putative manganese efflux pump MntP; Probably functions as a manganese efflux pump. Belongs to the MntP (TC 9.B.29) family.


ensembl_gene_id: HALO3505
symbol: HALO3505
gene_biotype: protein_coding
description:
  Putative urea active transporter 1; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.


ensembl_gene_id: HALO3509
symbol: HALO3509
gene_biotype: protein_coding
description:
  Streptomycin 3''-adenylyltransferase; Mediates bacterial resistance to the antibiotics streptomycin and spectomycin.


ensembl_gene_id: HALO3520
symbol: HALO3520
gene_biotype: protein_coding
description:
  Putative uncharacterized protein; Belongs to the low molecular weight phosphotyrosine protein phosphatase family.


ensembl_gene_id: HALO3550
symbol: HALO3550
gene_biotype: protein_coding
description:
  Putative uncharacterized protein; Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway; Belongs to the TenA family.


ensembl_gene_id: HALO3551
symbol: thiC
gene_biotype: protein_coding
description:
  Phosphomethylpyrimidine synthase ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.


ensembl_gene_id: HALO3560
symbol: HALO3560
gene_biotype: protein_coding
description:
  TRAP transporter, DctP family, hypothetical; Part of the tripartite ATP-independent periplasmic (TRAP) transport system.


ensembl_gene_id: HALO3563
symbol: ackA-2
gene_biotype: protein_coding
description:
  Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family.


ensembl_gene_id: HALO3564
symbol: HALO3564
gene_biotype: protein_coding
description:
  Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family.


ensembl_gene_id: HALO3572
symbol: HALO3572
gene_biotype: protein_coding
description:
  Nucleoside transporter CNT; Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.


ensembl_gene_id: HALO3573
symbol: HALO3573
gene_biotype: protein_coding
description:
  Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate.


ensembl_gene_id: HALO3574
symbol: deoA
gene_biotype: protein_coding
description:
  Thymidine phosphorylase; The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.


ensembl_gene_id: HALO3575
symbol: deoB
gene_biotype: protein_coding
description:
  Phosphopentomutase-Phosphodeoxyribomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family.


ensembl_gene_id: HALO3577
symbol: HALO3577
gene_biotype: protein_coding
description:
  Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.


ensembl_gene_id: HALO3589
symbol: tpx
gene_biotype: protein_coding
description:
  Probable thiol peroxidase; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Tpx subfamily.


ensembl_gene_id: HALO3591
symbol: nfi
gene_biotype: protein_coding
description:
  Endonuclease V; DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.


ensembl_gene_id: HALO3630
symbol: HALO3630
gene_biotype: protein_coding
description:
  Nitrate reductase, subunit alpha; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily.


ensembl_gene_id: HALO3632
symbol: HALO3632
gene_biotype: protein_coding
description:
  Nitrite reductase (NAD(P)H) large subunit, NirB; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.


ensembl_gene_id: HALO3655
symbol: HALO3655
gene_biotype: protein_coding
description:
  Multidrug/microcin transport system ATP-binding/permease protein; Fused multidrug transport subunits of ABC superfamily transporter: permease component/ATP-binding component.


ensembl_gene_id: HALO3656
symbol: HALO3656
gene_biotype: protein_coding
description:
  Iron(3+)-hydroxamate import system permease protein FhuB; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.


ensembl_gene_id: HALO3690
symbol: rlpA-2
gene_biotype: protein_coding
description:
  RlpA-like protein; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.


ensembl_gene_id: HALO3712
symbol: msrP
gene_biotype: protein_coding
description:
  Sulfoxide reductase catalytic subunit YedY; Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to re [...]


ensembl_gene_id: HALO3713
symbol: msrQ
gene_biotype: protein_coding
description:
  Sulfoxide reductase heme-binding subunit YedZ; Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalyti [...]


ensembl_gene_id: HALO3726
symbol: HALO3726
gene_biotype: protein_coding
description:
  P-hydroxybenzoic acid efflux system component; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.


ensembl_gene_id: HALO3729
symbol: HALO3729
gene_biotype: protein_coding
description:
  Short-chain dehydrogenase/reductase SDR; Belongs to the short-chain dehydrogenases/reductases (SDR) family.


ensembl_gene_id: HALO3734
symbol: HALO3734
gene_biotype: protein_coding
description:
  Uncharacterized oxidoreductase DltE; Belongs to the short-chain dehydrogenases/reductases (SDR) family.


ensembl_gene_id: HALO3797
symbol: guaB
gene_biotype: protein_coding
description:
  Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.


ensembl_gene_id: HALO3799
symbol: xseA
gene_biotype: protein_coding
description:
  Exodeoxyribonuclease 7 large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family.


ensembl_gene_id: HALO3812
symbol: mnmC
gene_biotype: protein_coding
description:
  tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC; Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34; In the C-terminal section; belongs to the DAO family.


ensembl_gene_id: HALO3814
symbol: ligA
gene_biotype: protein_coding
description:
  DNA ligase-Polydeoxyribonucleotide synthase [NAD(+)]; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.


ensembl_gene_id: HALO3815
symbol: zipA
gene_biotype: protein_coding
description:
  Cell division protein ZipA; Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins.


ensembl_gene_id: HALO3816
symbol: smc
gene_biotype: protein_coding
description:
  Chromosome partition protein Smc; Required for chromosome condensation and partitioning. Belongs to the SMC family.


ensembl_gene_id: HALO3821
symbol: ccmE
gene_biotype: protein_coding
description:
  Cytochrome c-type biogenesis protein CcmE; Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH. Belongs to the CcmE/CycJ family.


ensembl_gene_id: HALO3822
symbol: HALO3822
gene_biotype: protein_coding
description:
  Heme exporter protein D; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmD/CycX/HelD family.


ensembl_gene_id: HALO3823
symbol: ccmC
gene_biotype: protein_coding
description:
  Heme exporter protein C; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmC/CycZ/HelC family.


ensembl_gene_id: HALO3824
symbol: HALO3824
gene_biotype: protein_coding
description:
  Cytochrome c-type biogenesis protein CcmB; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmB/CycW/HelB family.


ensembl_gene_id: HALO3825
symbol: ccmA
gene_biotype: protein_coding
description:
  ABC transporter, heme export, CcmA; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family.


ensembl_gene_id: HALO3828
symbol: HALO3828
gene_biotype: protein_coding
description:
  Putative oxaloacetate decarboxylase beta chain; Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation; Belongs to the GcdB/MmdB/OadB family.


ensembl_gene_id: HALO3830
symbol: oadG
gene_biotype: protein_coding
description:
  Probable oxaloacetate decarboxylase gamma chain; Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation.


ensembl_gene_id: HALO3831
symbol: dusC
gene_biotype: protein_coding
description:
  tRNA-dihydrouridine synthase; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U16 in tRNAs. Belongs to the Dus family. DusC subfamily.


ensembl_gene_id: HALO3832
symbol: csrA
gene_biotype: protein_coding
description:
  Carbon storage regulator homolog; A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s).


ensembl_gene_id: HALO3834
symbol: alaS
gene_biotype: protein_coding
description:
  Alanine--tRNA ligase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.


ensembl_gene_id: HALO3836
symbol: recA
gene_biotype: protein_coding
description:
  Recombinase RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.


ensembl_gene_id: HALO3838
symbol: mutS
gene_biotype: protein_coding
description:
  DNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.


ensembl_gene_id: HALO3839
symbol: HALO3839
gene_biotype: protein_coding
description:
  Ferredoxin 1; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.


ensembl_gene_id: HALO3840
symbol: eno
gene_biotype: protein_coding
description:
  Enolase-2-phospho-D-glycerate hydro-lyase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.


ensembl_gene_id: HALO3842
symbol: pyrG
gene_biotype: protein_coding
description:
  CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.


ensembl_gene_id: HALO3845
symbol: aroB
gene_biotype: protein_coding
description:
  3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).


ensembl_gene_id: HALO3846
symbol: aroK
gene_biotype: protein_coding
description:
  Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family.


ensembl_gene_id: HALO3864
symbol: dinB
gene_biotype: protein_coding
description:
  DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.


ensembl_gene_id: HALO3865
symbol: selO
gene_biotype: protein_coding
description:
  Putative uncharacterized protein; Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation). Belongs to the SELO family.


ensembl_gene_id: HALO3884
symbol: rnz
gene_biotype: protein_coding
description:
  Ribonuclease Z; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA; Belongs to the RNase Z family.


ensembl_gene_id: HALO3905
symbol: ilvE
gene_biotype: protein_coding
description:
  Branched-chain amino acid aminotransferase I; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.


ensembl_gene_id: HALO3924
symbol: HALO3924
gene_biotype: protein_coding
description:
  Putative uncharacterized protein; Involved in peptidolytic degradation of cyclic heptapeptide hepatotoxin microcystin (MC); Belongs to the peptidase M81 family.


ensembl_gene_id: HALO3926
symbol: queA
gene_biotype: protein_coding
description:
  S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).


ensembl_gene_id: HALO3927
symbol: tgt
gene_biotype: protein_coding
description:
  Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form t [...]


ensembl_gene_id: HALO3928
symbol: yajC
gene_biotype: protein_coding
description:
  Preprotein translocase subunit YajC; The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions.


ensembl_gene_id: HALO3929
symbol: secD
gene_biotype: protein_coding
description:
  Protein translocase subunit SecD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.


ensembl_gene_id: HALO3930
symbol: secF
gene_biotype: protein_coding
description:
  Protein-export membrane protein SecF; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.


ensembl_gene_id: HALO3937
symbol: ndk
gene_biotype: protein_coding
description:
  Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.


ensembl_gene_id: HALO3938
symbol: rlmN
gene_biotype: protein_coding
description:
  Dual-specificity RNA methyltransferase RlmN; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity; Belongs to the radical SAM superfamily. RlmN family.


ensembl_gene_id: HALO3941
symbol: ispG
gene_biotype: protein_coding
description:
  4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family.


ensembl_gene_id: HALO3944
symbol: bamB
gene_biotype: protein_coding
description:
  Outer membrane protein assembly factor BamB; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.


ensembl_gene_id: HALO3945
symbol: der
gene_biotype: protein_coding
description:
  GTPase Der-GTP-binding protein EngA; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.


ensembl_gene_id: HALO3949
symbol: aroE
gene_biotype: protein_coding
description:
  Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).


ensembl_gene_id: HALO3950
symbol: hemF
gene_biotype: protein_coding
description:
  Coproporphyrinogen-III oxidase, aerobic; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX.


ensembl_gene_id: HALO3951
symbol: tsaC
gene_biotype: protein_coding
description:
  Threonylcarbamoyl-AMP synthase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate.


ensembl_gene_id: HALO3954
symbol: def
gene_biotype: protein_coding
description:
  Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.


ensembl_gene_id: HALO3955
symbol: fmt
gene_biotype: protein_coding
description:
  Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family.


ensembl_gene_id: HALO3956
symbol: HALO3956
gene_biotype: protein_coding
description:
  Ribosomal RNA small subunit methyltransferase B; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.


ensembl_gene_id: HALO3964
symbol: bioB
gene_biotype: protein_coding
description:
  Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family.


ensembl_gene_id: HALO3965
symbol: bioF
gene_biotype: protein_coding
description:
  8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.


ensembl_gene_id: HALO3967
symbol: bioC
gene_biotype: protein_coding
description:
  Malonyl-[acyl-carrier protein] O-methyltransferase; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway.


ensembl_gene_id: HALO3968
symbol: bioD
gene_biotype: protein_coding
description:
  ATP-dependent dethiobiotin synthetase BioD; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring.


ensembl_gene_id: HALO3971
symbol: aceK
gene_biotype: protein_coding
description:
  Isocitrate dehydrogenase kinase/phosphatase; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.


ensembl_gene_id: HALO3977
symbol: opgH
gene_biotype: protein_coding
description:
  Glucans biosynthesis glucosyltransferase H; Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs).


ensembl_gene_id: HALO4006
symbol: HALO4006
gene_biotype: protein_coding
description:
  Antimicrobial peptide transporter subunit ATP-binding component of ABC superfamily transporter; Belongs to the ABC transporter superfamily.


ensembl_gene_id: HALO4010
symbol: HALO4010
gene_biotype: protein_coding
description:
  Superoxide dismutase (Cu-Zn) 1; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family.


ensembl_gene_id: HALO4013
symbol: HALO4013
gene_biotype: protein_coding
description:
  Bacterioferritin; Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex; Belongs to the bacterioferritin family.


ensembl_gene_id: HALO4018
symbol: pepA
gene_biotype: protein_coding
description:
  Probable cytosol aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides.


ensembl_gene_id: HALO4023
symbol: valS
gene_biotype: protein_coding
description:
  Valine--tRNA ligase-Valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.


ensembl_gene_id: HALO4029
symbol: HALO4029
gene_biotype: protein_coding
description:
  Putative sulfate/thiosulfate transporter subunit: ATP-binding component of ABC superfamily transporter.


ensembl_gene_id: HALO4041
symbol: HALO4041
gene_biotype: protein_coding
description:
  Phospho-2-dehydro-3-deoxyheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP).


ensembl_gene_id: HALO4045
symbol: ubiD
gene_biotype: protein_coding
description:
  3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis.


ensembl_gene_id: HALO4046
symbol: rho-2
gene_biotype: protein_coding
description:
  Transcription termination factor Rho-ATP-dependent helicase Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template.


ensembl_gene_id: HALO4048
symbol: tilS
gene_biotype: protein_coding
description:
  tRNA(Ile)-lysidine synthase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family.


ensembl_gene_id: HALO4049
symbol: accA
gene_biotype: protein_coding
description:
  Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.


ensembl_gene_id: HALO4052
symbol: lpxB
gene_biotype: protein_coding
description:
  Lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.


ensembl_gene_id: HALO4053
symbol: lpxA
gene_biotype: protein_coding
description:
  Acyl---UDP-N-acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.


ensembl_gene_id: HALO4054
symbol: fabZ
gene_biotype: protein_coding
description:
  3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.


ensembl_gene_id: HALO4055
symbol: lpxD
gene_biotype: protein_coding
description:
  UDP-3-O-acylglucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily.


ensembl_gene_id: HALO4057
symbol: bamA
gene_biotype: protein_coding
description:
  Outer membrane protein assembly factor BamA; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.


ensembl_gene_id: HALO4059
symbol: dxr
gene_biotype: protein_coding
description:
  1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family.


ensembl_gene_id: HALO4061
symbol: uppS
gene_biotype: protein_coding
description:
  Ditrans,polycis-undecaprenyl-diphosphate synthase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di- trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide.


ensembl_gene_id: HALO4062
symbol: frr
gene_biotype: protein_coding
description:
  Ribosome-releasing factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family.


ensembl_gene_id: HALO4064
symbol: tsf
gene_biotype: protein_coding
description:
  Elongation factor Ts; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family.


ensembl_gene_id: HALO4068
symbol: glnD
gene_biotype: protein_coding
description:
  [Protein-PII] uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism.


ensembl_gene_id: HALO4071
symbol: dapD
gene_biotype: protein_coding
description:
  2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA.


ensembl_gene_id: HALO4072
symbol: dapE
gene_biotype: protein_coding
description:
  Succinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily.


ensembl_gene_id: HALO4079
symbol: mutM
gene_biotype: protein_coding
description:
  Formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.


ensembl_gene_id: HALO4083
symbol: HALO4083
gene_biotype: protein_coding
description:
  Coenzyme A biosynthesis bifunctional protein CoaBC; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family.


ensembl_gene_id: HALO4084
symbol: dut
gene_biotype: protein_coding
description:
  Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family.


ensembl_gene_id: HALO4086
symbol: argB
gene_biotype: protein_coding
description:
  Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily.


ensembl_gene_id: HALO4087
symbol: slmA
gene_biotype: protein_coding
description:
  Nucleoid occlusion factor SlmA; Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions.


ensembl_gene_id: HALO4088
symbol: rpoH
gene_biotype: protein_coding
description:
  RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes.


ensembl_gene_id: HALO4089
symbol: HALO4089
gene_biotype: protein_coding
description:
  Cell division protein FtsX; Part of the ABC transporter FtsEX involved in cellular division; Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.


ensembl_gene_id: HALO4090
symbol: ftsE
gene_biotype: protein_coding
description:
  ABC transporter ATP-binding protein; Part of the ABC transporter FtsEX involved in cellular division.


ensembl_gene_id: HALO4091
symbol: ftsY
gene_biotype: protein_coding
description:
  Signal recognition particle receptor FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.


ensembl_gene_id: HALO4092
symbol: HALO4092
gene_biotype: protein_coding
description:
  Ribosomal RNA small subunit methyltransferase D; Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle; Belongs to the methyltransferase superfamily. RsmD family.


ensembl_gene_id: HALO4100
symbol: prfB
gene_biotype: protein_coding
description:
  Peptide chain release factor 2; Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.


ensembl_gene_id: HALO4114
symbol: HALO4114
gene_biotype: protein_coding
description:
  Thiol:disulfide interchange protein DsbC; Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process; Belongs to the thioredoxin family. DsbC subfamily.


ensembl_gene_id: HALO4115
symbol: xerD
gene_biotype: protein_coding
description:
  Tyrosine recombinase XerD; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.


ensembl_gene_id: HALO4116
symbol: rplS
gene_biotype: protein_coding
description:
  50S ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.


ensembl_gene_id: HALO4117
symbol: trmD
gene_biotype: protein_coding
description:
  tRNA (guanine-N(1)-)-methyltransferase; Specifically methylates guanosine-37 in various tRNAs. Belongs to the RNA methyltransferase TrmD family.


ensembl_gene_id: HALO4118
symbol: rimM
gene_biotype: protein_coding
description:
  Ribosome maturation factor RimM; An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes; Belongs to the RimM family.


ensembl_gene_id: HALO4120
symbol: ffh
gene_biotype: protein_coding
description:
  Signal recognition particle protein-Fifty-four homolog; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the  [...]


ensembl_gene_id: HALO4128
symbol: minE
gene_biotype: protein_coding
description:
  Cell division topological specificity factor; Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.


ensembl_gene_id: HALO4130
symbol: minC
gene_biotype: protein_coding
description:
  Probable septum site-determining protein MinC; Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization; Belongs to the MinC family.


ensembl_gene_id: HALO4148
symbol: lldD
gene_biotype: protein_coding
description:
  L-lactate dehydrogenase [cytochrome]; Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain; Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.


ensembl_gene_id: HALO4161
symbol: ligB
gene_biotype: protein_coding
description:
  DNA ligase B; Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. Belongs to the NAD-dependent DNA ligase family. LigB subfamily.


ensembl_gene_id: HALO4162
symbol: metK
gene_biotype: protein_coding
description:
  S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.


ensembl_gene_id: HALO4166
symbol: HALO4166
gene_biotype: protein_coding
description:
  D-erythrose 4-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.


ensembl_gene_id: HALO4168
symbol: HALO4168
gene_biotype: protein_coding
description:
  Fructose-bisphosphate aldolase, class II, Calvin cycle subty; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.


ensembl_gene_id: HALO4175
symbol: tyrS
gene_biotype: protein_coding
description:
  Tyrosine--tRNA ligase-Tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.


ensembl_gene_id: HALO4176
symbol: anmK
gene_biotype: protein_coding
description:
  Anhydro-N-acetylmuramic acid kinase-AnhMurNAc kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family.


ensembl_gene_id: HALO4178
symbol: HALO4178
gene_biotype: protein_coding
description:
  UPF0001 protein PM; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.


ensembl_gene_id: HALO4179
symbol: proC
gene_biotype: protein_coding
description:
  Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.


ensembl_gene_id: HALO4181
symbol: metXS
gene_biotype: protein_coding
description:
  Homoserine O-acetyltransferase-Homoserine O-trans-acetylase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.


ensembl_gene_id: HALO4186
symbol: dksA
gene_biotype: protein_coding
description:
  RNA polymerase-binding transcription factor DksA; Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression.


ensembl_gene_id: HALO4187
symbol: gluQ
gene_biotype: protein_coding
description:
  Glutamyl-Q tRNA(Asp) synthetase; Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2- cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon; Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily.


ensembl_gene_id: HALO4191
symbol: pcnB
gene_biotype: protein_coding
description:
  Poly(A) polymerase, PcnB; Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control. Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.


ensembl_gene_id: HALO4193
symbol: panB
gene_biotype: protein_coding
description:
  3-methyl-2-oxobutanoate hydroxymethyltransferase-Ketopantoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family.


ensembl_gene_id: HALO4194
symbol: panC
gene_biotype: protein_coding
description:
  Pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family.


ensembl_gene_id: HALO4195
symbol: panD
gene_biotype: protein_coding
description:
  Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.


ensembl_gene_id: HALO4198
symbol: pnp
gene_biotype: protein_coding
description:
  Polyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction.


ensembl_gene_id: HALO4199
symbol: rpsO
gene_biotype: protein_coding
description:
  30S ribosomal protein S15; Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.


ensembl_gene_id: HALO4200
symbol: truB
gene_biotype: protein_coding
description:
  tRNA pseudouridine synthase B; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.


ensembl_gene_id: HALO4201
symbol: rbfA
gene_biotype: protein_coding
description:
  Ribosome-binding factor A; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.


ensembl_gene_id: HALO4202
symbol: infB
gene_biotype: protein_coding
description:
  Translation initiation factor IF-2; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.


ensembl_gene_id: HALO4203
symbol: nusA
gene_biotype: protein_coding
description:
  Transcription termination factor NusA; Participates in both transcription termination and antitermination.


ensembl_gene_id: HALO4204
symbol: rimP
gene_biotype: protein_coding
description:
  Ribosome maturation factor RimP; Required for maturation of 30S ribosomal subunits. Belongs to the RimP family.


ensembl_gene_id: HALO4205
symbol: HALO4205
gene_biotype: protein_coding
description:
  Protein-export membrane protein SecG; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family.


ensembl_gene_id: HALO4206
symbol: tpiA-2
gene_biotype: protein_coding
description:
  Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family.


ensembl_gene_id: HALO4207
symbol: glmM
gene_biotype: protein_coding
description:
  Phosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family.


ensembl_gene_id: HALO4208
symbol: HALO4208
gene_biotype: protein_coding
description:
  Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives.


ensembl_gene_id: HALO4209
symbol: ftsH
gene_biotype: protein_coding
description:
  ATP-dependent zinc metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family.  In the central section; belongs to the AAA ATPase family.


ensembl_gene_id: HALO4210
symbol: rlmE
gene_biotype: protein_coding
description:
  Ribosomal RNA large subunit methyltransferase E; Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.


ensembl_gene_id: HALO4212
symbol: greA
gene_biotype: protein_coding
description:
  Transcription elongation factor GreA; Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.


ensembl_gene_id: HALO4215
symbol: dapB
gene_biotype: protein_coding
description:
  4-hydroxy-tetrahydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family.


ensembl_gene_id: HALO4218
symbol: HALO4218
gene_biotype: protein_coding
description:
  Transport system permease; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.


ensembl_gene_id: HALO4221
symbol: dnaJ
gene_biotype: protein_coding
description:
  Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]


ensembl_gene_id: HALO4223
symbol: grpE
gene_biotype: protein_coding
description:
  Protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]


ensembl_gene_id: HALO4226
symbol: bamE
gene_biotype: protein_coding
description:
  Outer membrane protein assembly factor BamE; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.


ensembl_gene_id: HALO4229
symbol: smpB
gene_biotype: protein_coding
description:
  SsrA-binding protein; Required for rescue of stalled ribosomes mediated by trans- translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to [...]


ensembl_gene_id: HALO4262
symbol: phnC-2
gene_biotype: protein_coding
description:
  ABC transporter, phosphonate import, PhnC; Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphonates importer (TC 3.A.1.9.1) family.


ensembl_gene_id: HALO4271
symbol: proB
gene_biotype: protein_coding
description:
  Glutamate 5-kinase-Gamma-glutamyl kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.


ensembl_gene_id: HALO4272
symbol: obg
gene_biotype: protein_coding
description:
  GTPase obg-GTP-binding protein obg; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.


ensembl_gene_id: HALO4274
symbol: rplU
gene_biotype: protein_coding
description:
  50S ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family.


ensembl_gene_id: HALO4280
symbol: HALO4280
gene_biotype: protein_coding
description:
  K03566 LysR family transcriptional regulator,glycine cleavage system transcriptional activator; Belongs to the LysR transcriptional regulatory family.


ensembl_gene_id: HALO4287
symbol: HALO4287
gene_biotype: protein_coding
description:
  Fanconi-associated nuclease 1-like protein; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family.


ensembl_gene_id: HALO4292
symbol: HALO4292
gene_biotype: protein_coding
description:
  Putative peptide transport fused subunits of ABC superfamily: ATP-binding components; Belongs to the ABC transporter superfamily.


ensembl_gene_id: HALO4301
symbol: ugpE
gene_biotype: protein_coding
description:
  Sn-glycerol-3-phosphate transport system permease protein UgpE; Part of the binding-protein-dependent transport system for sn-glycerol-3-phosphate; probably responsible for the translocation of the substrate across the membrane.


ensembl_gene_id: HALO4302
symbol: ugpC
gene_biotype: protein_coding
description:
  Putative sugar transporter subunit: ATP-binding component of ABC superfamily transporter; Part of the ABC transporter complex UgpABCE involved in sn- glycerol-3-phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. sn-glycerol-3- phosphate importer (TC 3.A.1.1.3) family.


ensembl_gene_id: HALO4311
symbol: phnC-3
gene_biotype: protein_coding
description:
  Phosphate-import ATP-binding protein PhnC; Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphonates importer (TC 3.A.1.9.1) family.


ensembl_gene_id: HALO4321
symbol: ntrC
gene_biotype: protein_coding
description:
  Nitrogen regulation protein NR(I); Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes.


ensembl_gene_id: HALO4330
symbol: cas1
gene_biotype: protein_coding
description:
  CRISPR-associated endonuclease Cas1; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.


ensembl_gene_id: HALO4348
symbol: thiM
gene_biotype: protein_coding
description:
  Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family.


ensembl_gene_id: HALO4349
symbol: thiE
gene_biotype: protein_coding
description:
  Thiamine-phosphate synthase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.


ensembl_gene_id: HALO4356
symbol: rpoA
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.


ensembl_gene_id: HALO4357
symbol: rpsD
gene_biotype: protein_coding
description:
  30S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.


ensembl_gene_id: HALO4358
symbol: rpsK
gene_biotype: protein_coding
description:
  30S ribosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family.


ensembl_gene_id: HALO4359
symbol: rpsM
gene_biotype: protein_coding
description:
  30S ribosomal protein S13; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Belongs to the universal ribosomal protein uS13 family.


ensembl_gene_id: HALO4360
symbol: secY
gene_biotype: protein_coding
description:
  Protein translocase subunit SecY; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.


ensembl_gene_id: HALO4361
symbol: rplO
gene_biotype: protein_coding
description:
  50S ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family.


ensembl_gene_id: HALO4363
symbol: rpsE
gene_biotype: protein_coding
description:
  30S ribosomal protein S5; Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body. Belongs to the universal ribosomal protein uS5 family.


ensembl_gene_id: HALO4364
symbol: rplR
gene_biotype: protein_coding
description:
  50S ribosomal protein L18; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.


ensembl_gene_id: HALO4365
symbol: rplF
gene_biotype: protein_coding
description:
  50S ribosomal protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family.


ensembl_gene_id: HALO4366
symbol: rpsH
gene_biotype: protein_coding
description:
  30S ribosomal protein S8; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family.


ensembl_gene_id: HALO4367
symbol: rpsN
gene_biotype: protein_coding
description:
  30S ribosomal protein S14; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site; Belongs to the universal ribosomal protein uS14 family.


ensembl_gene_id: HALO4368
symbol: rplE
gene_biotype: protein_coding
description:
  50S ribosomal protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.


ensembl_gene_id: HALO4369
symbol: rplX
gene_biotype: protein_coding
description:
  50S ribosomal protein L24; One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.


ensembl_gene_id: HALO4370
symbol: rplN
gene_biotype: protein_coding
description:
  50S ribosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family.


ensembl_gene_id: HALO4371
symbol: rpsQ
gene_biotype: protein_coding
description:
  30S ribosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.


ensembl_gene_id: HALO4373
symbol: rplP
gene_biotype: protein_coding
description:
  50S ribosomal protein L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family.


ensembl_gene_id: HALO4374
symbol: rpsC
gene_biotype: protein_coding
description:
  30S ribosomal protein S3; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family.


ensembl_gene_id: HALO4375
symbol: rplV
gene_biotype: protein_coding
description:
  50S ribosomal protein L22; The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.


ensembl_gene_id: HALO4376
symbol: rpsS
gene_biotype: protein_coding
description:
  30S ribosomal protein S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.


ensembl_gene_id: HALO4377
symbol: rplB
gene_biotype: protein_coding
description:
  50S ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family.


ensembl_gene_id: HALO4378
symbol: rplW
gene_biotype: protein_coding
description:
  50S ribosomal protein L23; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family.


ensembl_gene_id: HALO4380
symbol: rplC
gene_biotype: protein_coding
description:
  50S ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.


ensembl_gene_id: HALO4381
symbol: rpsJ
gene_biotype: protein_coding
description:
  30S ribosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family.


ensembl_gene_id: HALO4382
symbol: tuf
gene_biotype: protein_coding
description:
  Elongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis.


ensembl_gene_id: HALO4383
symbol: fusA
gene_biotype: protein_coding
description:
  Elongation factor G; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.


ensembl_gene_id: HALO4384
symbol: rpsG
gene_biotype: protein_coding
description:
  30S ribosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family.


ensembl_gene_id: HALO4385
symbol: rpsL
gene_biotype: protein_coding
description:
  30S ribosomal protein S12; Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.


ensembl_gene_id: HALO4386
symbol: rpoC
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.


ensembl_gene_id: HALO4388
symbol: rplL
gene_biotype: protein_coding
description:
  50S ribosomal protein L7/L12; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family.


ensembl_gene_id: HALO4389
symbol: rplJ
gene_biotype: protein_coding
description:
  50S ribosomal protein L10; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family.


ensembl_gene_id: HALO4390
symbol: rplA
gene_biotype: protein_coding
description:
  50S ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.


ensembl_gene_id: HALO4391
symbol: rplK
gene_biotype: protein_coding
description:
  50S ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.


ensembl_gene_id: HALO4392
symbol: nusG
gene_biotype: protein_coding
description:
  Transcription termination/antitermination protein nusG; Participates in transcription elongation, termination and antitermination.


ensembl_gene_id: HALO4393
symbol: secE
gene_biotype: protein_coding
description:
  Protein translocase subunit SecE; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation; Belongs to the SecE/SEC61-gamma family.


ensembl_gene_id: HALO4394
symbol: coaX
gene_biotype: protein_coding
description:
  Type III pantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.


ensembl_gene_id: HALO4395
symbol: birA
gene_biotype: protein_coding
description:
  Biotin--acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon.


ensembl_gene_id: HALO4400
symbol: HALO4400
gene_biotype: protein_coding
description:
  ABC transporter permease; Belongs to the binding-protein-dependent transport system permease family.


ensembl_gene_id: HALO4401
symbol: HALO4401
gene_biotype: protein_coding
description:
  High-affinity branched-chain amino acid transport system permease protein BraE; Belongs to the binding-protein-dependent transport system permease family.


ensembl_gene_id: HALO4406
symbol: rapA
gene_biotype: protein_coding
description:
  RNA polymerase-associated protein RapA; Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair; Belongs to the SNF2/RAD54 helicase family. RapA subfamily.


ensembl_gene_id: HALO4418
symbol: fabA
gene_biotype: protein_coding
description:
  3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase; Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E- (2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length.


ensembl_gene_id: HALO4423
symbol: HALO4423
gene_biotype: protein_coding
description:
  Single-stranded DNA-binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.


ensembl_gene_id: HALO4425
symbol: uvrA
gene_biotype: protein_coding
description:
  UvrABC system protein A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.


ensembl_gene_id: HALO4428
symbol: HALO4428
gene_biotype: protein_coding
description:
  Ribonucleoside-diphosphate reductase; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.


ensembl_gene_id: HALO4433
symbol: fliA
gene_biotype: protein_coding
description:
  RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes; Belongs to the sigma-70 factor family. FliA subfamily.


ensembl_gene_id: HALO4437
symbol: flhA
gene_biotype: protein_coding
description:
  Putative flagellar export pore protein; Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin; Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.


ensembl_gene_id: HALO4438
symbol: flhB
gene_biotype: protein_coding
description:
  Flagellar export pore protein; Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin; Belongs to the type III secretion exporter family.


ensembl_gene_id: HALO4439
symbol: HALO4439
gene_biotype: protein_coding
description:
  Protein phosphatase CheZ; Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P).


ensembl_gene_id: HALO4443
symbol: HALO4443
gene_biotype: protein_coding
description:
  Chemotaxis protein methyltransferase; Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP.


ensembl_gene_id: HALO4450
symbol: flhC
gene_biotype: protein_coding
description:
  Flagellar transcriptional regulator FlhC; Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non- flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways; Belongs to the FlhC family.


ensembl_gene_id: HALO4451
symbol: flhD
gene_biotype: protein_coding
description:
  Flagellar transcriptional regulator FlhD; Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non- flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways; Belongs to the FlhD family.


ensembl_gene_id: HALO4459
symbol: HALO4459
gene_biotype: protein_coding
description:
  Flagellar M-ring protein; The M ring may be actively involved in energy transduction. Belongs to the FliF family.


ensembl_gene_id: HALO4460
symbol: HALO4460
gene_biotype: protein_coding
description:
  Flagellar motor switch protein FliG; FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.


ensembl_gene_id: HALO4465
symbol: HALO4465
gene_biotype: protein_coding
description:
  Flagellar protein FliL; Controls the rotational direction of flagella during chemotaxis; Belongs to the FliL family.


ensembl_gene_id: HALO4466
symbol: HALO4466
gene_biotype: protein_coding
description:
  Flagellar motor switch protein FliM; FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.


ensembl_gene_id: HALO4467
symbol: HALO4467
gene_biotype: protein_coding
description:
  Flagellar motor switch protein FliN; FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation. Belongs to the FliN/MopA/SpaO family.


ensembl_gene_id: HALO4469
symbol: fliP
gene_biotype: protein_coding
description:
  Flagellar biosynthesis protein FliP; Plays a role in the flagellum-specific transport system. Belongs to the FliP/MopC/SpaP family.


ensembl_gene_id: HALO4470
symbol: fliQ
gene_biotype: protein_coding
description:
  Flagellar biosynthetic protein FliQ; Role in flagellar biosynthesis. Belongs to the FliQ/MopD/SpaQ family.


ensembl_gene_id: HALO4471
symbol: HALO4471
gene_biotype: protein_coding
description:
  Flagellar biosynthetic protein fliR; Role in flagellar biosynthesis. Belongs to the FliR/MopE/SpaR family.


ensembl_gene_id: HALO4475
symbol: flgI
gene_biotype: protein_coding
description:
  Flagellar P-ring protein; Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


ensembl_gene_id: HALO4476
symbol: flgH
gene_biotype: protein_coding
description:
  Flagellar L-ring protein; Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


ensembl_gene_id: HALO4480
symbol: HALO4480
gene_biotype: protein_coding
description:
  Basal-body rod modification protein flgD; Required for flagellar hook formation. May act as a scaffolding protein.


ensembl_gene_id: HALO4482
symbol: HALO4482
gene_biotype: protein_coding
description:
  Flagellar basal body rod protein FlgB; Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.


ensembl_gene_id: HALO4483
symbol: HALO4483
gene_biotype: protein_coding
description:
  Flagella basal body P-ring formation protein flgA; Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P- ring assembly; Belongs to the FlgA family.


ensembl_gene_id: HALO4487
symbol: HALO4487
gene_biotype: protein_coding
description:
  Aspartate carbamoyltransferase, eukaryotic; Belongs to the aspartate/ornithine carbamoyltransferase superfamily.


ensembl_gene_id: HALO4488
symbol: HALO4488
gene_biotype: protein_coding
description:
  Holliday junction resolvase; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF HJR family.


ensembl_gene_id: HALO4492
symbol: HALO4492
gene_biotype: protein_coding
description:
  SSS family solute/sodium (Na+) symporter; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.


ensembl_gene_id: HALO4495
symbol: secB
gene_biotype: protein_coding
description:
  Protein-export protein SecB; One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA.


ensembl_gene_id: HALO4497
symbol: gpmI
gene_biotype: protein_coding
description:
  2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate.


ensembl_gene_id: HALO4504
symbol: HALO4504
gene_biotype: protein_coding
description:
  Cell division protein ZapA; Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division.


ensembl_gene_id: HALO4506
symbol: ilvA
gene_biotype: protein_coding
description:
  Threonine dehydratase biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.


ensembl_gene_id: HALO4507
symbol: rpiA
gene_biotype: protein_coding
description:
  Ribose-5-phosphate isomerase A; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.


ensembl_gene_id: HALO4508
symbol: HALO4508
gene_biotype: protein_coding
description:
  3-deoxy-D-manno-octulosonic-acid transferase; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family.


ensembl_gene_id: HALO4509
symbol: hldE
gene_biotype: protein_coding
description:
  Bifunctional protein HldE; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. In the N-terminal section; belongs to the carbohydrate kinase PfkB family.


ensembl_gene_id: HALO4511
symbol: kdkA
gene_biotype: protein_coding
description:
  3-deoxy-D-manno-octulosonic acid kinase; Catalyzes the ATP-dependent phosphorylation of the 3-deoxy-D- manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position; Belongs to the protein kinase superfamily. KdkA/RfaP family.


ensembl_gene_id: HALO4520
symbol: hldD
gene_biotype: protein_coding
description:
  ADP-L-glycero-D-manno-heptose-6-epimerase; Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily.


ensembl_gene_id: HALO4524
symbol: gyrB
gene_biotype: protein_coding
description:
  DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.


ensembl_gene_id: HALO4525
symbol: recF
gene_biotype: protein_coding
description:
  DNA replication and repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.


ensembl_gene_id: HALO4526
symbol: HALO4526
gene_biotype: protein_coding
description:
  DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of  [...]


ensembl_gene_id: HALO4527
symbol: dnaA
gene_biotype: protein_coding
description:
  Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family.


ensembl_gene_id: HALO4529
symbol: rnpA
gene_biotype: protein_coding
description:
  Ribonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.


ensembl_gene_id: HALO4530
symbol: yidC
gene_biotype: protein_coding
description:
  Membrane protein insertase YidC; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.


ensembl_gene_id: HALO4531
symbol: mnmE
gene_biotype: protein_coding
description:
  tRNA modification GTPase MnmE; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.


ensembl_gene_id: HALO4534
symbol: HALO4534
gene_biotype: protein_coding
description:
  Putative oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family.


ensembl_gene_id: HALO4535
symbol: HALO4535
gene_biotype: protein_coding
description:
  Non-canonical purine NTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.


ensembl_gene_id: HALO4547
symbol: argC
gene_biotype: protein_coding
description:
  N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.


ensembl_gene_id: HALO4549
symbol: erpA
gene_biotype: protein_coding
description:
  Iron-sulfur cluster insertion protein ErpA; Required for insertion of 4Fe-4S clusters for at least IspG.


ensembl_gene_id: HALO4553
symbol: mnmG
gene_biotype: protein_coding
description:
  tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG; NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34; Belongs to the MnmG family.


ensembl_gene_id: HALO4554
symbol: rsmG
gene_biotype: protein_coding
description:
  Ribosomal RNA small subunit methyltransferase G; Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.


ensembl_gene_id: HALO4559
symbol: atpE-2
gene_biotype: protein_coding
description:
  ATP synthase subunit c; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.


ensembl_gene_id: HALO4561
symbol: atpH
gene_biotype: protein_coding
description:
  ATP synthase subunit delta; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.


ensembl_gene_id: HALO4563
symbol: atpG
gene_biotype: protein_coding
description:
  ATP synthase subunit gamma; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.


ensembl_gene_id: HALO4565
symbol: atpC-2
gene_biotype: protein_coding
description:
  ATP synthase epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane.


ensembl_gene_id: HALO4567
symbol: HALO4567
gene_biotype: protein_coding
description:
  Cation diffusion facilitator family transporter; Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family.


ensembl_gene_id: HALO4568
symbol: uppP-2
gene_biotype: protein_coding
description:
  Undecaprenyl-diphosphatase; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family.


ensembl_gene_id: HALO4570
symbol: glmU
gene_biotype: protein_coding
description:
  Bifunctional protein GlmU; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain.


ensembl_gene_id: HALO4571
symbol: glmS
gene_biotype: protein_coding
description:
  Glutamine--fructose-6-phosphate aminotransferase [isomerizing]; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.


ensembl_gene_id: HALO4578
symbol: rep
gene_biotype: protein_coding
description:
  DNA helicase, ATP-dependent, RepA type; Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replication; it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction.


ensembl_gene_id: HALO4579
symbol: trmL
gene_biotype: protein_coding
description:
  tRNA (cytidine(34)-2'-O)-methyltransferase; Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide.


ensembl_gene_id: HALO4580
symbol: pyrE
gene_biotype: protein_coding
description:
  Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).


ensembl_gene_id: HALO4582
symbol: rph
gene_biotype: protein_coding
description:
  Ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.


ensembl_gene_id: HALO4585
symbol: HALO4585
gene_biotype: protein_coding
description:
  Monosaccharide-transporting ATPase; Belongs to the binding-protein-dependent transport system permease family.


