# geneInfo

ensembl_gene_id: A0A1D8PC97
symbol: TUB2
gene_biotype: protein_coding
description:
  Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.


ensembl_gene_id: A0A1D8PCA4
symbol: RPO41
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the phage and mitochondrial RNA polymerase family.


ensembl_gene_id: A0A1D8PCC8
symbol: RRS1
gene_biotype: protein_coding
description:
  Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family.


ensembl_gene_id: A0A1D8PCG3
symbol: TRM2
gene_biotype: protein_coding
description:
  Trm2p; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.


ensembl_gene_id: A0A1D8PCG7
symbol: RPS21B
gene_biotype: protein_coding
description:
  40S ribosomal protein S21; Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Has a physiological role leading to 18S rRNA stability.


ensembl_gene_id: A0A1D8PCJ9
symbol: ARP8
gene_biotype: protein_coding
description:
  Actin-related protein 8; Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin remodeling complex. Belongs to the actin family.


ensembl_gene_id: A0A1D8PCL1
symbol: HGT1
gene_biotype: protein_coding
description:
  High-affinity glucose transporter 1; High-affinity glucose transporter. Acts as a multifunctional complement-evasion molecule that causes down-regulation of complement activation by acquisition of human complement factors FH and C4BP. Functions also as a human immunodeficiency virus (HIV) receptor via binding the viral gp160 protein. Modulates hyphae formation.


ensembl_gene_id: A0A1D8PCM2
symbol: GAL7
gene_biotype: protein_coding
description:
  Galactose-1-phosphate uridylyltransferase; Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.


ensembl_gene_id: A0A1D8PCQ3
symbol: CaO19.2930
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 2A; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl- tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.


ensembl_gene_id: A0A1D8PCQ7
symbol: CaO19.3667
gene_biotype: protein_coding
description:
  Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.


ensembl_gene_id: A0A1D8PCY1
symbol: ORC1
gene_biotype: protein_coding
description:
  Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.


ensembl_gene_id: A0A1D8PCY5
symbol: CDC12
gene_biotype: protein_coding
description:
  Septin; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.


ensembl_gene_id: A0A1D8PDC4
symbol: ATP1
gene_biotype: protein_coding
description:
  ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane.


ensembl_gene_id: A0A1D8PDC9
symbol: VPS16
gene_biotype: protein_coding
description:
  Probable vacuolar protein sorting-associated protein 16 homolog; Essential for vacuolar protein sorting. Required for vacuole biogenesis, stability and to maintain vacuole morphology.


ensembl_gene_id: A0A1D8PDD2
symbol: CaO19.783
gene_biotype: protein_coding
description:
  Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.


ensembl_gene_id: A0A1D8PDE3
symbol: SEC21
gene_biotype: protein_coding
description:
  Coatomer subunit gamma; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.


ensembl_gene_id: A0A1D8PDE8
symbol: YBN5
gene_biotype: protein_coding
description:
  Obg-like ATPase 1; Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.


ensembl_gene_id: A0A1D8PDK6
symbol: RIB4
gene_biotype: protein_coding
description:
  6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.


ensembl_gene_id: A0A1D8PDN3
symbol: TRP99
gene_biotype: protein_coding
description:
  Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily.


ensembl_gene_id: A0A1D8PE30
symbol: CaO19.2794
gene_biotype: protein_coding
description:
  Pyridoxal phosphate homeostasis protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'- phosphate (PLP), the active form of vitamin B6; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.


ensembl_gene_id: A0A1D8PE45
symbol: CaO19.5054
gene_biotype: protein_coding
description:
  Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family.


ensembl_gene_id: A0A1D8PE62
symbol: CaO19.2796
gene_biotype: protein_coding
description:
  DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.


ensembl_gene_id: A0A1D8PE70
symbol: CaO19.2786
gene_biotype: protein_coding
description:
  AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.


ensembl_gene_id: A0A1D8PE92
symbol: NTG1
gene_biotype: protein_coding
description:
  Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.


ensembl_gene_id: A0A1D8PE97
symbol: GCV2
gene_biotype: protein_coding
description:
  Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine.


ensembl_gene_id: A0A1D8PEA0
symbol: TERT
gene_biotype: protein_coding
description:
  Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.


ensembl_gene_id: A0A1D8PEA2
symbol: DPM1
gene_biotype: protein_coding
description:
  Dolichol-phosphate mannosyltransferase subunit 1; Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.


ensembl_gene_id: A0A1D8PEE2
symbol: CaO19.4727
gene_biotype: protein_coding
description:
  Succinate dehydrogenase assembly factor 2, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer.


ensembl_gene_id: A0A1D8PEF0
symbol: HEM14
gene_biotype: protein_coding
description:
  Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.


ensembl_gene_id: A0A1D8PEG2
symbol: ZWF1
gene_biotype: protein_coding
description:
  Glucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.


ensembl_gene_id: A0A1D8PEI6
symbol: ARG5,6
gene_biotype: protein_coding
description:
  Bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase; In the N-terminal section; belongs to the acetylglutamate kinase family.


ensembl_gene_id: A0A1D8PEK6
symbol: CaO19.4801
gene_biotype: protein_coding
description:
  tRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37; Belongs to the IPP transferase family.


ensembl_gene_id: A0A1D8PEL1
symbol: ERG12
gene_biotype: protein_coding
description:
  Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.


ensembl_gene_id: A0A1D8PEQ9
symbol: VPS41
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 41; Required for vacuolar assembly and vacuolar traffic. Belongs to the VPS41 family.


ensembl_gene_id: A0A1D8PEX3
symbol: RPA190
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.


ensembl_gene_id: A0A1D8PEY1
symbol: SFT2
gene_biotype: protein_coding
description:
  Protein transport protein SFT2; Nonessential protein required for the fusion of transport vesicles derived from the endocytic pathway with the Golgi complex. Belongs to the SFT2 family.


ensembl_gene_id: A0A1D8PF22
symbol: WBP1
gene_biotype: protein_coding
description:
  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the [...]


ensembl_gene_id: A0A1D8PF32
symbol: CHO1
gene_biotype: protein_coding
description:
  CDP-diacylglycerol--serine O-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.


ensembl_gene_id: A0A1D8PF56
symbol: GAR1
gene_biotype: protein_coding
description:
  H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine (psi) residues may serve to stabilize the conformation of rRNAs.


ensembl_gene_id: A0A1D8PF68
symbol: SAM2
gene_biotype: protein_coding
description:
  S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP.


ensembl_gene_id: A0A1D8PF88
symbol: CaO19.1140
gene_biotype: protein_coding
description:
  MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.


ensembl_gene_id: A0A1D8PFH5
symbol: PEP1
gene_biotype: protein_coding
description:
  Sortilin; Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A.


ensembl_gene_id: A0A1D8PFI3
symbol: RBK1
gene_biotype: protein_coding
description:
  Ribokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.


ensembl_gene_id: A0A1D8PFL7
symbol: RPN1
gene_biotype: protein_coding
description:
  26S proteasome regulatory subunit RPN1; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.


ensembl_gene_id: A0A1D8PFP3
symbol: KEM1
gene_biotype: protein_coding
description:
  5'-3' exoribonuclease 1; Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins.


ensembl_gene_id: A0A1D8PFS4
symbol: GND1
gene_biotype: protein_coding
description:
  6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.


ensembl_gene_id: A0A1D8PFU6
symbol: APL1
gene_biotype: protein_coding
description:
  AP complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.


ensembl_gene_id: A0A1D8PFV8
symbol: CaO19.7214
gene_biotype: protein_coding
description:
  17-beta-hydroxysteroid dehydrogenase-like protein; Belongs to the glycosyl hydrolase 5 (cellulase A) family.


ensembl_gene_id: A0A1D8PFZ9
symbol: MPP10
gene_biotype: protein_coding
description:
  U3 small nucleolar ribonucleoprotein protein MPP10; Involved in nucleolar processing of pre-18S ribosomal RNA. Belongs to the MPP10 family.


ensembl_gene_id: A0A1D8PG79
symbol: CaO19.2042
gene_biotype: protein_coding
description:
  TrmE-type G domain-containing protein; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.


ensembl_gene_id: A0A1D8PGC3
symbol: CaO19.1457
gene_biotype: protein_coding
description:
  General transcription and DNA repair factor IIH; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II; Belongs to the GTF2H2 family.


ensembl_gene_id: A0A1D8PGE0
symbol: A0A1D8PGE0
gene_biotype: protein_coding
description:
  Dynein light chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.


ensembl_gene_id: A0A1D8PGL4
symbol: CaO19.1573
gene_biotype: protein_coding
description:
  Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.


ensembl_gene_id: A0A1D8PGR1
symbol: TSR3
gene_biotype: protein_coding
description:
  Ribosome biogenesis protein TSR3; Ribosome biogenesis protein required for processing 35S pre- rRNA at site D; Belongs to the TSR3 family.


ensembl_gene_id: A0A1D8PH13
symbol: GCD7
gene_biotype: protein_coding
description:
  Translation initiation factor eIF2B subunit beta; Belongs to the eIF-2B alpha/beta/delta subunits family.


ensembl_gene_id: A0A1D8PH17
symbol: VMA7
gene_biotype: protein_coding
description:
  V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.


ensembl_gene_id: A0A1D8PH42
symbol: BAT21
gene_biotype: protein_coding
description:
  Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.


ensembl_gene_id: A0A1D8PH55
symbol: UGA1
gene_biotype: protein_coding
description:
  4-aminobutyrate transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.


ensembl_gene_id: A0A1D8PH56
symbol: CaO19.4516
gene_biotype: protein_coding
description:
  Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.


ensembl_gene_id: A0A1D8PH78
symbol: ERG20
gene_biotype: protein_coding
description:
  Bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase; Belongs to the FPP/GGPP synthase family.


ensembl_gene_id: A0A1D8PH98
symbol: ITR1
gene_biotype: protein_coding
description:
  Myo-inositol transporter; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.


ensembl_gene_id: A0A1D8PHH0
symbol: EFM4
gene_biotype: protein_coding
description:
  Protein-lysine N-methyltransferase EFM4; S-adenosyl-L-methionine-dependent protein-lysine N- methyltransferase that mono- and dimethylates elongation factor 1-alpha at 'Lys-316'. May play a role in intracellular transport. Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.


ensembl_gene_id: A0A1D8PHH7
symbol: IDP1
gene_biotype: protein_coding
description:
  Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family.


ensembl_gene_id: A0A1D8PHI5
symbol: COX9
gene_biotype: protein_coding
description:
  Cytochrome c oxidase subunit 7A; This small integral protein plays a role in holoenzyme assembly or stability.


ensembl_gene_id: A0A1D8PHI7
symbol: CaO19.6886
gene_biotype: protein_coding
description:
  Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family.


ensembl_gene_id: A0A1D8PHT9
symbol: OLE2
gene_biotype: protein_coding
description:
  Acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.


ensembl_gene_id: A0A1D8PHV8
symbol: RPA12
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.


ensembl_gene_id: A0A1D8PI00
symbol: GDH2
gene_biotype: protein_coding
description:
  NAD-specific glutamate dehydrogenase; NAD(+)-dependent glutamate dehydrogenase which degrades glutamate to ammonia and alpha-ketoglutarate. Belongs to the Glu/Leu/Phe/Val dehydrogenases family.


ensembl_gene_id: A0A1D8PI01
symbol: YCS4
gene_biotype: protein_coding
description:
  Condensin complex subunit 1; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.


ensembl_gene_id: A0A1D8PI21
symbol: MAF1
gene_biotype: protein_coding
description:
  Repressor of RNA polymerase III transcription MAF1; Mediator of diverse signals that repress RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA. Belongs to the MAF1 family.


ensembl_gene_id: A0A1D8PI52
symbol: RRP8
gene_biotype: protein_coding
description:
  Ribosomal RNA-processing protein 8; S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of adenine in helix 25.1 in 25S rRNA. Required both for ribosomal 40S and 60S subunits biogenesis. Required for efficient pre-rRNA cleavage at site A2. Belongs to the methyltransferase superfamily. RRP8 family.


ensembl_gene_id: A0A1D8PI78
symbol: TIM22
gene_biotype: protein_coding
description:
  Mitochondrial import inner membrane translocase subunit TIM22; Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity).


ensembl_gene_id: A0A1D8PIE7
symbol: CDC47
gene_biotype: protein_coding
description:
  DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]


ensembl_gene_id: A0A1D8PIG8
symbol: VMA21
gene_biotype: protein_coding
description:
  Vacuolar ATPase assembly integral membrane protein VMA21; Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum; Belongs to the VMA21 family.


ensembl_gene_id: A0A1D8PIH0
symbol: KAR3
gene_biotype: protein_coding
description:
  Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.


ensembl_gene_id: A0A1D8PIL8
symbol: CaO19.1774
gene_biotype: protein_coding
description:
  Formate dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.


ensembl_gene_id: A0A1D8PIN6
symbol: CaO19.1761
gene_biotype: protein_coding
description:
  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST2; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the [...]


ensembl_gene_id: A0A1D8PJ01
symbol: PMA1
gene_biotype: protein_coding
description:
  Plasma membrane ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.


ensembl_gene_id: A0A1D8PJB0
symbol: CaO19.1672
gene_biotype: protein_coding
description:
  Coatomer subunit alpha; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.


ensembl_gene_id: A0A1D8PJC6
symbol: CaO19.1638
gene_biotype: protein_coding
description:
  Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily.


ensembl_gene_id: A0A1D8PJH2
symbol: CaO19.252
gene_biotype: protein_coding
description:
  Mitochondrial pyruvate carrier; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.


ensembl_gene_id: A0A1D8PJJ8
symbol: APL5
gene_biotype: protein_coding
description:
  AP-3 complex subunit delta; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane.


ensembl_gene_id: A0A1D8PJJ9
symbol: YSY6
gene_biotype: protein_coding
description:
  Stress-associated endoplasmic reticulum protein; May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation. Belongs to the RAMP4 family.


ensembl_gene_id: A0A1D8PJL8
symbol: PNP1
gene_biotype: protein_coding
description:
  Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.


ensembl_gene_id: A0A1D8PJM0
symbol: DDC1
gene_biotype: protein_coding
description:
  DNA repair protein rad9; Acts in DNA repair and mutagenesis. Involved in promoting resistance to ionizing radiation and UV light, as well as regulating cell cycle progression after irradiation.


ensembl_gene_id: A0A1D8PJX3
symbol: RIP1
gene_biotype: protein_coding
description:
  Cytochrome b-c1 complex subunit Rieske, mitochondrial; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.


ensembl_gene_id: A0A1D8PJZ1
symbol: RAD53
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase RAD53; Controls S-phase checkpoint as well as G1 and G2 DNA damage checkpoints. Phosphorylates proteins on serine, threonine, and tyrosine. Prevents entry into anaphase and mitotic exit after DNA damage via regulation of the Polo kinase CDC5.


ensembl_gene_id: A0A1D8PK00
symbol: CUP5
gene_biotype: protein_coding
description:
  V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.


ensembl_gene_id: A0A1D8PK48
symbol: CaO19.5985
gene_biotype: protein_coding
description:
  Prefoldin subunit 3; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins; Belongs to the prefoldin subunit alpha family.


ensembl_gene_id: A0A1D8PK87
symbol: OST1
gene_biotype: protein_coding
description:
  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...]


ensembl_gene_id: A0A1D8PK89
symbol: GAP2
gene_biotype: protein_coding
description:
  General amino-acid permease GAP2; Amino-acid permease with broad substrate specificity. GAP2 is the only amino-acid permease with very broad substrate specificity, none of the other GAP permeases is able to transport such a variety of amino acids. GAP2 is also able to transport thialysine, and thus probably also lysine. Functions as a sensor via detection of some amino acids including methionine, leading to a rapid activation of trehalase, a downstream target of PKA ; Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.


ensembl_gene_id: A0A1D8PKA6
symbol: CaO19.6990
gene_biotype: protein_coding
description:
  Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.


ensembl_gene_id: A0A1D8PKC5
symbol: TRM12
gene_biotype: protein_coding
description:
  tRNA wybutosine-synthesizing protein 2; S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S- adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86.


ensembl_gene_id: A0A1D8PKC9
symbol: DNM1
gene_biotype: protein_coding
description:
  Dynamin-related GTPase; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.


ensembl_gene_id: A0A1D8PKD3
symbol: NOG1
gene_biotype: protein_coding
description:
  Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.


ensembl_gene_id: A0A1D8PKD5
symbol: ELP3
gene_biotype: protein_coding
description:
  Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation.


ensembl_gene_id: A0A1D8PKF2
symbol: CaO19.7420
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 6; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery.


ensembl_gene_id: A0A1D8PKH5
symbol: UNG1
gene_biotype: protein_coding
description:
  Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.


ensembl_gene_id: A0A1D8PKM5
symbol: OPI3
gene_biotype: protein_coding
description:
  Phosphatidyl-N-methylethanolamine N-methyltransferase; Catalyzes the second two steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylmonomethylethanolamine (PMME) to phosphatidyldimethylethanolamine (PDME) and of PDME to phosphatidylcholine (PC).


ensembl_gene_id: A0A1D8PKX2
symbol: CaO19.366
gene_biotype: protein_coding
description:
  DNA damage checkpoint control protein RAD17; Component of the checkpoint clamp complex involved in the surveillance mechanism that allows the DNA repair pathways to act to restore the integrity of the DNA prior to DNA synthesis or separation of the replicated chromosomes; Belongs to the rad1 family.


ensembl_gene_id: A0A1D8PKX3
symbol: VMA6
gene_biotype: protein_coding
description:
  V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. The active enzyme consists of a catalytic V1 domain attached to an integral membrane V0 proton pore complex. This subunit is a non-integral membrane component of the membrane pore domain and is required for proper assembly of the V0 sector. Might be involved in the regulated assembly of V1 subunits onto the membrane sector or alternatively may prevent the passage of protons through V0 pores; Belongs to the V-ATPase V0D/AC39 subunit family.


ensembl_gene_id: A0A1D8PKY4
symbol: PHR3
gene_biotype: protein_coding
description:
  1,3-beta-glucanosyltransferase; Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall; Belongs to the glycosyl hydrolase 72 family.


ensembl_gene_id: A0A1D8PKZ9
symbol: ATP2
gene_biotype: protein_coding
description:
  ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane.


ensembl_gene_id: A0A1D8PL00
symbol: CaO19.372
gene_biotype: protein_coding
description:
  Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.


ensembl_gene_id: A0A1D8PL01
symbol: STE24
gene_biotype: protein_coding
description:
  CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family.


ensembl_gene_id: A0A1D8PL26
symbol: CaO19.5678
gene_biotype: protein_coding
description:
  Diphthamide biosynthesis protein 2-2; Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.


ensembl_gene_id: A0A1D8PL51
symbol: CaO19.4161
gene_biotype: protein_coding
description:
  Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.


ensembl_gene_id: A0A1D8PL61
symbol: MDN1
gene_biotype: protein_coding
description:
  Midasin; Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits; Belongs to the midasin family.


ensembl_gene_id: A0A1D8PL67
symbol: QRI7
gene_biotype: protein_coding
description:
  tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.


ensembl_gene_id: A0A1D8PLF1
symbol: DPM3
gene_biotype: protein_coding
description:
  Dolichol-phosphate mannosyltransferase subunit 3; Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER. Belongs to the DPM3 family.


ensembl_gene_id: A0A1D8PLJ3
symbol: SOD1
gene_biotype: protein_coding
description:
  Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family.


ensembl_gene_id: A0A1D8PLN4
symbol: MED20
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 20; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.


ensembl_gene_id: A0A1D8PLP8
symbol: UBR1
gene_biotype: protein_coding
description:
  E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.


ensembl_gene_id: A0A1D8PLR7
symbol: NCP1
gene_biotype: protein_coding
description:
  NADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis. In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.


ensembl_gene_id: A0A1D8PLW3
symbol: CaO19.1306
gene_biotype: protein_coding
description:
  Fe2OG dioxygenase domain-containing protein; Belongs to the iron/ascorbate-dependent oxidoreductase family.


ensembl_gene_id: A0A1D8PLY3
symbol: RAM1
gene_biotype: protein_coding
description:
  Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.


ensembl_gene_id: A0A1D8PLY4
symbol: PYC2
gene_biotype: protein_coding
description:
  Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.


ensembl_gene_id: A0A1D8PM29
symbol: SEC15
gene_biotype: protein_coding
description:
  Exocyst complex component SEC15; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.


ensembl_gene_id: A0A1D8PM81
symbol: A0A1D8PM81
gene_biotype: protein_coding
description:
  MICOS complex subunit MIC10; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.


ensembl_gene_id: A0A1D8PM83
symbol: ARG8
gene_biotype: protein_coding
description:
  Acetylornithine transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.


ensembl_gene_id: A0A1D8PM97
symbol: RAD59
gene_biotype: protein_coding
description:
  DNA repair protein RAD59; Involved in the repair of double-strand breaks in DNA during vegetative growth via recombination and single-strand annealing. Anneals complementary single-stranded DNA.


ensembl_gene_id: A0A1D8PMC8
symbol: BRN1
gene_biotype: protein_coding
description:
  Condensin complex subunit 2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.


ensembl_gene_id: A0A1D8PMD4
symbol: TUB4
gene_biotype: protein_coding
description:
  Tubulin gamma chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome.


ensembl_gene_id: A0A1D8PME6
symbol: CGT1
gene_biotype: protein_coding
description:
  mRNA-capping enzyme subunit alpha; Second step of mRNA capping. Transfer of the GMP moiety of GTP to the 5'-end of RNA via an enzyme-GMP covalent reaction intermediate; Belongs to the eukaryotic GTase family.


ensembl_gene_id: A0A1D8PMH5
symbol: VPS13
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein; May be involved in recycling of membrane proteins between an endocytic compartment and the TGN; Belongs to the VPS13 family.


ensembl_gene_id: A0A1D8PML0
symbol: PRI2
gene_biotype: protein_coding
description:
  DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family.


ensembl_gene_id: A0A1D8PMM1
symbol: TOP2
gene_biotype: protein_coding
description:
  DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.


ensembl_gene_id: A0A1D8PMP1
symbol: GUT2
gene_biotype: protein_coding
description:
  Glycerol-3-phosphate dehydrogenase; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.


ensembl_gene_id: A0A1D8PMP9
symbol: CaO19.3124
gene_biotype: protein_coding
description:
  Methionine aminopeptidase; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val).


ensembl_gene_id: A0A1D8PMQ1
symbol: A0A1D8PMQ1
gene_biotype: protein_coding
description:
  Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.


ensembl_gene_id: A0A1D8PMT6
symbol: CaO19.5689
gene_biotype: protein_coding
description:
  Coatomer subunit epsilon; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Belongs to the COPE family.


ensembl_gene_id: A0A1D8PMU0
symbol: CaO19.5694
gene_biotype: protein_coding
description:
  Genetic interactor of prohibitin 5, mitochondrial; Essential for respiratory growth and required for maintenance of mtDNA. Required for cell survival in the absence of prohibitins. Belongs to the GEP5 family.


ensembl_gene_id: A0A1D8PMU5
symbol: CaO19.5684
gene_biotype: protein_coding
description:
  Mitochondrial 54S ribosomal protein YmL38/YmL34; Belongs to the universal ribosomal protein uL14 family.


ensembl_gene_id: A0A1D8PMU9
symbol: AFL1
gene_biotype: protein_coding
description:
  Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates  [...]


ensembl_gene_id: A0A1D8PMZ3
symbol: RMT2
gene_biotype: protein_coding
description:
  Arginine N-methyltransferase 2; S-adenosyl-L-methionine-dependent protein-arginine N- methyltransferase that methylates the delta-nitrogen atom of arginine residues to form N5-methylarginine (type IV) in target proteins. Monomethylates ribosomal protein L12.


ensembl_gene_id: A0A1D8PN03
symbol: FOL1
gene_biotype: protein_coding
description:
  Folic acid synthesis protein fol1; Catalyzes three sequential steps of tetrahydrofolate biosynthesis; In the C-terminal section; belongs to the DHPS family.  In the central section; belongs to the HPPK family.


ensembl_gene_id: A0A1D8PN12
symbol: GIT2
gene_biotype: protein_coding
description:
  Glycerophosphodiester transporter GIT2; Probable glycerophosphodiester transporter. Does not possess detectable glycerophosphoinositol (GroPIns) transport activity. Might be involved in the uptake of glycerophosphocholine (GroPCho). The expanded ability to utilize GroPIns and GroPCho results from the organism's pathogenic nature and its need to occupy a variety of environments within its host organism. This possibility is buttressed by the fact that GroPIns and GroPCho are present and abundant in human fluids ; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1 [...]


ensembl_gene_id: A0A1D8PN14
symbol: GIT4
gene_biotype: protein_coding
description:
  Glycerophosphocholine permease GIT4; Glycerophosphodiester transporter that mediates uptake of glycerophosphocholine (GroPCho) with GIT3. Does not possess detectable glycerophosphoinositol (GroPIns) transport activity. The expanded ability to utilize GroPIns and GroPCho results from the organism's pathogenic nature and its need to occupy a variety of environments within its host organism. This possibility is buttressed by the fact that GroPIns and GroPCho are present and abundant in human fluids.


ensembl_gene_id: A0A1D8PN45
symbol: VPS1
gene_biotype: protein_coding
description:
  Dynamin-like GTPase; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.


ensembl_gene_id: A0A1D8PN46
symbol: COQ7
gene_biotype: protein_coding
description:
  5-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides.


ensembl_gene_id: A0A1D8PN68
symbol: CaO19.4153
gene_biotype: protein_coding
description:
  NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-ULA1 E1 enzyme.


ensembl_gene_id: A0A1D8PNA7
symbol: CaO19.3169
gene_biotype: protein_coding
description:
  GPN-loop GTPase 2; Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family.


ensembl_gene_id: A0A1D8PNB3
symbol: CaO19.3175
gene_biotype: protein_coding
description:
  Electron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone.


ensembl_gene_id: A0A1D8PNC0
symbol: ORC4
gene_biotype: protein_coding
description:
  Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family.


ensembl_gene_id: A0A1D8PND9
symbol: RET2
gene_biotype: protein_coding
description:
  Coatomer subunit delta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.


ensembl_gene_id: A0A1D8PNE8
symbol: CaO19.3167
gene_biotype: protein_coding
description:
  Protoheme IX farnesyltransferase, mitochondrial; Converts protoheme IX and farnesyl diphosphate to heme O. Belongs to the ubiA prenyltransferase family.


ensembl_gene_id: A0A1D8PNE9
symbol: CaO19.4247
gene_biotype: protein_coding
description:
  Derlin; May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins; Belongs to the derlin family.


ensembl_gene_id: A0A1D8PNG4
symbol: SPR28
gene_biotype: protein_coding
description:
  Spr28p; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.


ensembl_gene_id: A0A1D8PNI6
symbol: CKB2
gene_biotype: protein_coding
description:
  Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family.


ensembl_gene_id: A0A1D8PNJ9
symbol: LSM8
gene_biotype: protein_coding
description:
  U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.


ensembl_gene_id: A0A1D8PNM2
symbol: CaO19.4346
gene_biotype: protein_coding
description:
  Protein transport protein sec16; Involved in the initiation of assembly of the COPII coat required for the formation of transport vesicles from the endoplasmic reticulum (ER) and the selection of cargo molecules. Also involved in autophagy; Belongs to the SEC16 family.


ensembl_gene_id: A0A1D8PNN9
symbol: RMS1
gene_biotype: protein_coding
description:
  Ribosomal lysine N-methyltransferase 4; S-adenosyl-L-methionine-dependent protein-lysine N- methyltransferase that monomethylates 60S ribosomal protein L42. Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily.


ensembl_gene_id: A0A1D8PNP0
symbol: A0A1D8PNP0
gene_biotype: protein_coding
description:
  37S ribosomal protein mrp10, mitochondrial; Involved in mitochondrial genome encoded proteins translation.


ensembl_gene_id: A0A1D8PNP3
symbol: GAP6
gene_biotype: protein_coding
description:
  Amino-acid permease GAP6; Amino-acid permease with rather broad substrate specificity. Transports many amino acids including proline, methionine, leucine, valine, isoleucine, phenylalanine, tryptophan, threonine and tyrosine, but not basic ones (arginine) and citrulline. Functions as a sensor via detection of some amino acids including methionine, leading to a rapid activation of trehalase, a downstream target of PKA.


ensembl_gene_id: A0A1D8PNZ7
symbol: GDE1
gene_biotype: protein_coding
description:
  Glycerophosphocholine phosphodiesterase GDE1; Glycerophosphocholine glycerophosphodiesterase responsible for the hydrolysis of intracellular glycerophosphocholine into glycerol-phosphate and choline. The choline is used for phosphatidyl-choline synthesis. Required for utilization of glycerophosphocholine as phosphate source. C.albicans can utilize GroPCho through transport and intracellular hydrolysis or through extracellular hydrolysis.


ensembl_gene_id: A0A1D8PPB0
symbol: STV1
gene_biotype: protein_coding
description:
  V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.


ensembl_gene_id: A0A1D8PPC1
symbol: DPM2
gene_biotype: protein_coding
description:
  Dolichol phosphate-mannose biosynthesis regulatory protein; Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization. Belongs to the DPM2 family.


ensembl_gene_id: A0A1D8PPC8
symbol: A0A1D8PPC8
gene_biotype: protein_coding
description:
  Small nuclear ribonucleoprotein E; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family.


ensembl_gene_id: A0A1D8PPI2
symbol: TOP1
gene_biotype: protein_coding
description:
  DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]


ensembl_gene_id: A0A1D8PPI5
symbol: CAN1
gene_biotype: protein_coding
description:
  Lysine/arginine permease CAN1; High-affinity permease for basic amino acids arginine, lysine and histidine.


ensembl_gene_id: A0A1D8PPI7
symbol: CaO19.119
gene_biotype: protein_coding
description:
  Protein-S-isoprenylcysteine O-methyltransferase; Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.


ensembl_gene_id: A0A1D8PPP5
symbol: MED19
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 19; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.


ensembl_gene_id: A0A1D8PPV5
symbol: SEC27
gene_biotype: protein_coding
description:
  Coatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.


ensembl_gene_id: A0A1D8PPW6
symbol: NIP7
gene_biotype: protein_coding
description:
  60S ribosome subunit biogenesis protein NIP7; Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly; Belongs to the NIP7 family.


ensembl_gene_id: A0A1D8PPW9
symbol: GCV1
gene_biotype: protein_coding
description:
  Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.


ensembl_gene_id: A0A1D8PPX2
symbol: CaO19.5516
gene_biotype: protein_coding
description:
  Signal recognition particle subunit SRP72; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane; Belongs to the SRP72 family.


ensembl_gene_id: A0A1D8PQ44
symbol: CaO19.5608
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerase III subunit RPC6; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs; Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.


ensembl_gene_id: A0A1D8PQ75
symbol: FDC1
gene_biotype: protein_coding
description:
  Ferulic acid decarboxylase 1; Catalyzes the reversible decarboxylation of aromatic carboxylic acids like ferulic acid, p-coumaric acid or cinnamic acid, producing the corresponding vinyl derivatives 4-vinylphenol, 4- vinylguaiacol, and styrene, respectively, which play the role of aroma metabolites; Belongs to the UbiD family. UbiD-like/FDC subfamily.


ensembl_gene_id: A0A1D8PQ82
symbol: NOG2
gene_biotype: protein_coding
description:
  Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.


ensembl_gene_id: A0A1D8PQ84
symbol: PAD1
gene_biotype: protein_coding
description:
  Flavin prenyltransferase PAD1, mitochondrial; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for the ferulic acid decarboxylase FDC1. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family.


ensembl_gene_id: A0A1D8PQ86
symbol: ALS9
gene_biotype: protein_coding
description:
  Agglutinin-like protein 9; Cell surface adhesion protein which mediates both yeast-to- host tissue adherence and yeast aggregation. Plays an important role in the pathogenesis of C.albicans infections. Allele ALS9-2 contributes to endothelial cell adhesion, whereas ALS9-1 does not.


ensembl_gene_id: A0A1D8PQ95
symbol: SNQ2
gene_biotype: protein_coding
description:
  ATP-binding cassette transporter; Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.


ensembl_gene_id: A0A1D8PQB9
symbol: ALS4
gene_biotype: protein_coding
description:
  Agglutinin-like protein 4; Cell surface adhesion protein which mediates both yeast-to- host tissue adherence and yeast aggregation. Plays an important role in the pathogenesis of C.albicans infections.


ensembl_gene_id: A0A1D8PQC5
symbol: SEC5
gene_biotype: protein_coding
description:
  Exocyst complex component SEC5; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family.


ensembl_gene_id: A0A1D8PQD5
symbol: A0A1D8PQD5
gene_biotype: protein_coding
description:
  Cytochrome c oxidase subunit; This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.


ensembl_gene_id: A0A1D8PQE0
symbol: CaO19.1092
gene_biotype: protein_coding
description:
  Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase; Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-Dol.


ensembl_gene_id: A0A1D8PQG0
symbol: NAG3
gene_biotype: protein_coding
description:
  Major facilitator superfamily multidrug transporter NAG3; MFS transporter involved in N-acetylglucosamine (GlcNAc) uptake. Confers resistance to cycloheximide, 4- nitroquinoline-N-oxide, and 1,10-phenanthroline, and contributes to virulence. Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.


ensembl_gene_id: A0A1D8PQG3
symbol: DAC1
gene_biotype: protein_coding
description:
  N-acetylglucosamine-6-phosphate deacetylase; Belongs to the metallo-dependent hydrolases superfamily. NagA family.


ensembl_gene_id: A0A1D8PQH5
symbol: SOD3
gene_biotype: protein_coding
description:
  Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.


ensembl_gene_id: A0A1D8PQH7
symbol: ADK2
gene_biotype: protein_coding
description:
  GTP:AMP phosphotransferase, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.


ensembl_gene_id: A0A1D8PQK5
symbol: LEU2
gene_biotype: protein_coding
description:
  3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.


ensembl_gene_id: A0A1D8PQK6
symbol: PMR1
gene_biotype: protein_coding
description:
  Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.


ensembl_gene_id: A0A1D8PQL3
symbol: THG1
gene_biotype: protein_coding
description:
  tRNA(His) guanylyltransferase; Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage.


ensembl_gene_id: A0A1D8PQL4
symbol: CaO19.7088
gene_biotype: protein_coding
description:
  Threonylcarbamoyl-AMP synthase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.


ensembl_gene_id: A0A1D8PQL5
symbol: PEL1
gene_biotype: protein_coding
description:
  CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin; Belongs to the CDP-alcohol phosphatidyltransferase class-II family.


ensembl_gene_id: A0A1D8PQM4
symbol: RPA135
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.


ensembl_gene_id: A0A1D8PQQ3
symbol: GPH1
gene_biotype: protein_coding
description:
  Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.


ensembl_gene_id: A0A1D8PQR0
symbol: PHM5
gene_biotype: protein_coding
description:
  Endopolyphosphatase; Catalyzes the hydrolysis of inorganic polyphosphate (polyP) chains of many hundreds of phosphate residues into shorter lengths.


ensembl_gene_id: A0A1D8PQS0
symbol: RPP0
gene_biotype: protein_coding
description:
  60S acidic ribosomal protein P0; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome t [...]


ensembl_gene_id: A0A1D8PQT2
symbol: MRE11
gene_biotype: protein_coding
description:
  Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.


ensembl_gene_id: A0A1D8PQT4
symbol: GCN3
gene_biotype: protein_coding
description:
  Translation initiation factor eIF2B subunit alpha; Belongs to the eIF-2B alpha/beta/delta subunits family.


ensembl_gene_id: A0A1D8PR28
symbol: CaO19.6502
gene_biotype: protein_coding
description:
  Short-chain dehydrogenase/reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family.


ensembl_gene_id: A0A1D8PR41
symbol: CaO19.6462
gene_biotype: protein_coding
description:
  ER membrane protein complex subunit 3; The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER). Belongs to the EMC3 family.


ensembl_gene_id: A0A1D8PR50
symbol: LSM4
gene_biotype: protein_coding
description:
  U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA.


ensembl_gene_id: A0A1D8PR52
symbol: CaO19.6463
gene_biotype: protein_coding
description:
  GPN-loop GTPase; Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.


ensembl_gene_id: A0A1D8PRB8
symbol: A0A1D8PRB8
gene_biotype: protein_coding
description:
  COX assembly mitochondrial protein; Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration; Belongs to the CMC family.


ensembl_gene_id: A0A1D8PRE9
symbol: HIS7
gene_biotype: protein_coding
description:
  Imidazole glycerol phosphate synthase hisHF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain. Belongs to the HisA/HisF family.


ensembl_gene_id: A0A1D8PRF4
symbol: CaO19.7197
gene_biotype: protein_coding
description:
  Nucleolar complex-associated protein 3; Required for synthesis of 60S ribosomal subunits and the transport of pre-ribosomes from the nucleoplasm to the cytoplasm. Belongs to the CBF/MAK21 family.


ensembl_gene_id: A0A1D8PRG8
symbol: CaO19.7202
gene_biotype: protein_coding
description:
  Protein RER1; Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.


ensembl_gene_id: A0A1D8PRH8
symbol: MED9
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 9; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.


ensembl_gene_id: A0A1D8PRI0
symbol: NPT1
gene_biotype: protein_coding
description:
  Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family.


ensembl_gene_id: A0A1D8PRM6
symbol: RRM3
gene_biotype: protein_coding
description:
  ATP-dependent DNA helicase RRM3; 5' to 3' DNA replicative helicase recruited to paused replisomes to promote fork progression throughout nonhistone protein- DNA complexes, naturally occurring impediments that are encountered in each S phase where replication forks pauses. Required for timely replication of the telomere and subtelomeric DNA and for wild-type levels of telomeric silencing. Involved in DNA repair during stalled replication fork, regulation of fragile sites expression and essential for genome stability. Plays also a role in mtDNA replication. Has G- quadruplex (G4) unwindi [...]


ensembl_gene_id: A0A1D8PRN2
symbol: CaO19.7499
gene_biotype: protein_coding
description:
  Nicotinamide-nucleotide adenylyltransferase; Belongs to the eukaryotic NMN adenylyltransferase family.


ensembl_gene_id: A0A1D8PRP8
symbol: LEU1
gene_biotype: protein_coding
description:
  3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.


ensembl_gene_id: A0A1D8PRU4
symbol: ARC19
gene_biotype: protein_coding
description:
  Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family.


ensembl_gene_id: A0A1D8PRY9
symbol: A0A1D8PRY9
gene_biotype: protein_coding
description:
  Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum.


ensembl_gene_id: A0A1D8PS08
symbol: CaO19.2552
gene_biotype: protein_coding
description:
  Cation_ATPase_C domain-containing protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.


ensembl_gene_id: A0A1D8PS98
symbol: RPC31
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerase III subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.


ensembl_gene_id: A0A1D8PSD0
symbol: DOM34
gene_biotype: protein_coding
description:
  Protein DOM34 homolog; May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs.


ensembl_gene_id: A0A1D8PSJ0
symbol: CaO19.4365
gene_biotype: protein_coding
description:
  Uncharacterized protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.


ensembl_gene_id: A0A1D8PSN8
symbol: CaO19.501
gene_biotype: protein_coding
description:
  rRNA (Cytosine-C5-)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.


ensembl_gene_id: A0A1D8PSP7
symbol: SNP3
gene_biotype: protein_coding
description:
  U6 snRNA-associated Sm-like protein LSm2; Binds specifically to the 3'-terminal U-tract of U6 snRNA.


ensembl_gene_id: A0A1D8PSR2
symbol: CaO19.518
gene_biotype: protein_coding
description:
  tRNA (Cytosine-5-)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.


ensembl_gene_id: A0A1D8PSV9
symbol: MED5
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 5; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.


ensembl_gene_id: A0A1D8PSX0
symbol: VMA13
gene_biotype: protein_coding
description:
  V-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system.


ensembl_gene_id: A0A1D8PT08
symbol: RNR3
gene_biotype: protein_coding
description:
  Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.


ensembl_gene_id: A0A1D8PT38
symbol: CEK2
gene_biotype: protein_coding
description:
  Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.


ensembl_gene_id: A0A1D8PT60
symbol: ARC40
gene_biotype: protein_coding
description:
  Actin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks; Belongs to the WD repeat ARPC1 family.


ensembl_gene_id: A0A1D8PTB5
symbol: LSC2
gene_biotype: protein_coding
description:
  Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.


ensembl_gene_id: A0A1D8PTD0
symbol: POL2
gene_biotype: protein_coding
description:
  DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.


ensembl_gene_id: A0A1D8PTF3
symbol: CaO19.6152
gene_biotype: protein_coding
description:
  Protein arginine methyltransferase NDUFAF7; Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).


ensembl_gene_id: A0A1D8PTG5
symbol: SMX4
gene_biotype: protein_coding
description:
  U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA.


ensembl_gene_id: A0A1D8PTV1
symbol: LSM1
gene_biotype: protein_coding
description:
  U6 snRNA-associated Sm-like protein LSm1; Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation.


ensembl_gene_id: A0A1D8PTV4
symbol: TUB1
gene_biotype: protein_coding
description:
  Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.


ensembl_gene_id: A0A1D8PTW6
symbol: ERG13
gene_biotype: protein_coding
description:
  3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.


ensembl_gene_id: A0A1D8PTX1
symbol: ARP2
gene_biotype: protein_coding
description:
  Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.


ensembl_gene_id: A0A1D8PTX6
symbol: CaO19.7307
gene_biotype: protein_coding
description:
  NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.


ensembl_gene_id: A0A1D8PU08
symbol: CaO19.6602
gene_biotype: protein_coding
description:
  Ubiquinone biosynthesis protein; Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.


ensembl_gene_id: A0A1D8PU24
symbol: BET2
gene_biotype: protein_coding
description:
  Geranylgeranyl transferase type-2 subunit beta; Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C- terminal sequence -XXCC, -XCXC and -CCXX.


ensembl_gene_id: A0A1D8PU61
symbol: FDH3
gene_biotype: protein_coding
description:
  S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.


ensembl_gene_id: A0A1D8PU83
symbol: COQ2
gene_biotype: protein_coding
description:
  4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.


ensembl_gene_id: A0A1D8PU84
symbol: CaO19.7615
gene_biotype: protein_coding
description:
  Trafficking protein particle complex subunit; Plays a key role in the late stages of endoplasmic reticulum to Golgi traffic.


ensembl_gene_id: A0A1D8PU96
symbol: SLD5
gene_biotype: protein_coding
description:
  DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family.


ensembl_gene_id: A0A1D8PUC1
symbol: CaO19.7673
gene_biotype: protein_coding
description:
  Small nuclear ribonucleoprotein Sm D1; Involved in pre-mRNA splicing. Binds snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site; Belongs to the snRNP core protein family.


ensembl_gene_id: G1UB37
symbol: FLU1
gene_biotype: protein_coding
description:
  Major facilitator superfamily multidrug transporter FLU1; Major facilitator superfamily transporter that mediates resistance to structurally and functionally unrelated compounds including cycloheximide but also azoles such as fuconazole, ketoconazole and itraconazole. Mediates also efflux of histatin 5, a salivary human antimicrobial peptide, and is responsible for reduction of its toxicity in C.albicans. Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.


ensembl_gene_id: G1UB61
symbol: CDC11
gene_biotype: protein_coding
description:
  Septin CDC11; Septins are GTPases involved in cytokinesis that assemble early in the cell cycle as a patch at the incipient bud site and form a ring before bud emergence, which transforms into an hour-glass shaped collar of cortical filaments that spans both sides of the mother-bud neck. This collar persists until just before cytokinesis, when it splits into two rings that occupy opposite sides of the neck. The septins at the bud neck serve as a structural scaffold that recruits different components involved in diverse processes at specific stages during the cell cycle. Many proteins b [...]


ensembl_gene_id: G1UB62
symbol: CaO19.5157
gene_biotype: protein_coding
description:
  Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors  [...]


ensembl_gene_id: G1UB63
symbol: CSA1
gene_biotype: protein_coding
description:
  Cell wall protein 1; Heme-binding protein involved in heme-iron utilization. The ability to acquire iron from host tissues is a major virulence factor of pathogenic microorganisms. Required for biofilm formation.


ensembl_gene_id: G1UB67
symbol: DEF1
gene_biotype: protein_coding
description:
  Transcriptional regulator DEF1; Transcriptional regulator involved in extension of germ tubes into elongated hyphae and maintenance of filamentous growth. Regulates expression of UME6. Acts in a pathway that regulates maintenance of hyphal growth by repressing hyphal-to-yeast transition and allows dissemination within host epithelial tissues. Dispensable for invasion into both host oral epithelial cells and enterocytes, but required for epithelial damage.


ensembl_gene_id: G1UBC2
symbol: EAP1
gene_biotype: protein_coding
description:
  Cell wall adhesin EAP1; Cell wall protein which mediates cell-cell and cell-substrate adhesion. Required for biofilm formation and plays a role in virulence. Belongs to the PGA18 family.


ensembl_gene_id: O13289
symbol: CAT1
gene_biotype: protein_coding
description:
  Peroxisomal catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Required for hyphal growth.


ensembl_gene_id: O13318
symbol: PHR2
gene_biotype: protein_coding
description:
  pH-responsive protein 2; Required for apical cell growth and plays an essential role in morphogenesis. May be integral to the pathogenic ability of the organism (By similarity).


ensembl_gene_id: O13332
symbol: AUR1
gene_biotype: protein_coding
description:
  Inositol phosphorylceramide synthase; Catalyzes the addition of a phosphorylinositol group onto ceramide to form inositol phosphorylceramide, an essential step in sphingolipid biosynthesis; Belongs to the AUR1 family.


ensembl_gene_id: O13426
symbol: SHM2
gene_biotype: protein_coding
description:
  Serine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine; Belongs to the SHMT family.


ensembl_gene_id: O42817
symbol: RPS0
gene_biotype: protein_coding
description:
  40S ribosomal protein S0; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits; Belongs to the universal ribosomal protein uS2 family.


ensembl_gene_id: O43101
symbol: CBF5
gene_biotype: protein_coding
description:
  H/ACA ribonucleoprotein complex subunit CBF5; Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs and play a central role in ribosomal RNA processing. The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs. Catalyzes pseudouridylation at position 93 in U2 snRNA. Also catalyzes pseudouridy [...]


ensembl_gene_id: O43133
symbol: TBP1
gene_biotype: protein_coding
description:
  TATA-box-binding protein; General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II.


ensembl_gene_id: O59923
symbol: SIR2
gene_biotype: protein_coding
description:
  NAD-dependent histone deacetylase SIR2; NAD-dependent deacetylase. Heterochromatin component that silences transcription at silent mating loci, telomeres and the ribosomal DNA, and that also suppresses recombination in the rDNA and extends replicative life span. It acts as a NAD-dependent histone deacetylase, which deacetylates 'Lys-9' and 'Lys-14' of Histone H3 and 'Lys-16' of Histone H4. Functions in the distribution of oxidatively damaged proteins during cell division. Mediates phenotypic switching.


ensembl_gene_id: O59933
symbol: ERG25
gene_biotype: protein_coding
description:
  Methylsterol monooxygenase; Catalyzes the first step in the removal of the two C-4 methyl groups of 4,4-dimethylzymosterol; Belongs to the sterol desaturase family.


ensembl_gene_id: O74161
symbol: CHS5
gene_biotype: protein_coding
description:
  Chitin biosynthesis protein CHS5; Involved in chitin synthesis and also required for mating. Belongs to the CHS5 family.


ensembl_gene_id: O74189
symbol: PMT1
gene_biotype: protein_coding
description:
  Dolichyl-phosphate-mannose--protein mannosyltransferase 1; Protein mannosyltransferase (PMT) involved in hyphal growth and drug sensitivity. Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. PMT1, PMT2 and PMT4 account for most of the protein-O-glycosylation activity, while PMT5 and PMT6 may specifically modulate a much narrower spectrum of target proteins. Accounts for the O-glycosylation of the cell wall proteins KRE9, PIR2, RHD3, and ALS1, as well as the SEC20 t-SNARE component. O-glycosylation of SEC20 is essential for its stability. Required for filamentatio [...]


ensembl_gene_id: O74198
symbol: ERG6
gene_biotype: protein_coding
description:
  Sterol 24-C-methyltransferase; Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol.


ensembl_gene_id: O74201
symbol: UBC2
gene_biotype: protein_coding
description:
  Ubiquitin-conjugating enzyme E2 2; Catalyzes the covalent attachment of ubiquitin to other proteins. Plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. Also involved in postreplication repair of UV-damaged DNA, in N-end rule-dependent protein degradation and in sporulation.


ensembl_gene_id: O74261
symbol: HSP60
gene_biotype: protein_coding
description:
  Heat shock protein 60, mitochondrial; May participate in assembly and/or disassembly of proteins imported into the mitochondrion. HSP60 are ATPases and have affinity for unfolded proteins (By similarity); Belongs to the chaperonin (HSP60) family.


ensembl_gene_id: O74711
symbol: PEX5
gene_biotype: protein_coding
description:
  Peroxisomal targeting signal receptor; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import.


ensembl_gene_id: O93803
symbol: CET1
gene_biotype: protein_coding
description:
  mRNA-capping enzyme subunit beta; First step of mRNA capping. Converts the 5'-triphosphate end of a nascent mRNA chain into a diphosphate end.


ensembl_gene_id: O93827
symbol: MPG1
gene_biotype: protein_coding
description:
  Mannose-1-phosphate guanyltransferase; Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell-size checkpoint (By similarity); Belongs to the transferase hexapeptide repeat family.


ensembl_gene_id: O94030
symbol: MIA40
gene_biotype: protein_coding
description:
  Mitochondrial intermembrane space import and assembly protein 40; Required for the import and folding of small cysteine- containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Forms a redox cycle with ERV1 that involves a disulfide relay system. Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond  [...]


ensembl_gene_id: O94048
symbol: HEM3
gene_biotype: protein_coding
description:
  Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.


ensembl_gene_id: O94069
symbol: HEM1
gene_biotype: protein_coding
description:
  5-aminolevulinate synthase, mitochondrial; Catalyzes the synthesis of 5-aminolevulinate (ALA) from succinyl-CoA and glycine, the first and rate-limiting step in heme biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.


ensembl_gene_id: O94083
symbol: ANB1
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 5A; mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis (By similarity).


ensembl_gene_id: P0C075
symbol: ATG8
gene_biotype: protein_coding
description:
  Autophagy-related protein 8; Ubiquitin-like modifier involved in autophagosomes formation. With ATG4, mediates the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Participates also in membrane fusion events that take place in the early secretory pathway. Also involved [...]


ensembl_gene_id: P0C0X3
symbol: TFB5
gene_biotype: protein_coding
description:
  General transcription and DNA repair factor IIH subunit TFB5; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has be [...]


ensembl_gene_id: P0C8K9
symbol: COX1
gene_biotype: protein_coding
description:
  Cytochrome c oxidase subunit 1; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...]


ensembl_gene_id: P0C8L0
symbol: COB
gene_biotype: protein_coding
description:
  Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.


ensembl_gene_id: P0CB54
symbol: GET3
gene_biotype: protein_coding
description:
  ATPase GET3; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. S [...]


ensembl_gene_id: P0CB63
symbol: GET2
gene_biotype: protein_coding
description:
  Golgi to ER traffic protein 2; Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP- dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER.


ensembl_gene_id: P0CH67
symbol: LAB5
gene_biotype: protein_coding
description:
  Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.


ensembl_gene_id: P0CH96
symbol: ADE12
gene_biotype: protein_coding
description:
  Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity). Belongs to the adenylosuccinate synthetase family.


ensembl_gene_id: P0CT51
symbol: BLP1
gene_biotype: protein_coding
description:
  Blood-induced peptide 1; Plays an important role in survival in host blood through increasing tolerance to stresses such as heat, salt, or cycloheximide, which is essential for virulence.


ensembl_gene_id: P0CU34
symbol: TSA1B
gene_biotype: protein_coding
description:
  Peroxiredoxin TSA1-B; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Also involved in the correct composition of the hyphal cell wall.


ensembl_gene_id: P0CU36
symbol: CaO19.7398
gene_biotype: protein_coding
description:
  Ribosome biogenesis protein C3_06160C_A; Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles (By similarity).


ensembl_gene_id: P0CU37
symbol: CaO19.6676
gene_biotype: protein_coding
description:
  Diphthine methyl ester synthase 2; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.


ensembl_gene_id: P0CU38
symbol: ALS2
gene_biotype: protein_coding
description:
  Agglutinin-like protein 2; Cell surface adhesion protein which mediates both yeast-to- host tissue adherence and yeast aggregation. Plays an important role in the pathogenesis of C.albicans infections. Belongs to the ALS family.


ensembl_gene_id: P0CY19
symbol: DUT1
gene_biotype: protein_coding
description:
  Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.


ensembl_gene_id: P0CY20
symbol: HAL21
gene_biotype: protein_coding
description:
  3'(2'),5'-bisphosphate nucleotidase 1; Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. Regulates the flux of sulfur in the sulfur- activation pathway by converting PAPS to APS. Involved in salt tolerance (By similarity).


ensembl_gene_id: P0CY22
symbol: KRE1
gene_biotype: protein_coding
description:
  Protein KRE1; Involved in cell wall 1,6-beta-glucan assembly possibly by the addition of linear side chains of 1,6-linked Glc units to a highly branched 1,6- and 1,3-linked glucan backbone; Belongs to the KRE1 family.


ensembl_gene_id: P0CY24
symbol: CST20
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase CST20; MAP4K component of the MAPK pathway required for the mating pheromone response, and the regulation of cell polarity and cell cycle. Phosphorylates histone H2B to form H2BS10ph (By similarity). Required for hyphal formation and virulence; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.


ensembl_gene_id: P0CY27
symbol: SAP1
gene_biotype: protein_coding
description:
  Candidapepsin-1; Secreted aspartic peptidases (SAPs) are a group of ten acidic hydrolases considered as key virulence factors. These enzymes supply the fungus with nutrient amino acids as well as are able to degrade the selected host's proteins involved in the immune defense. Induces host inflammatory cytokine production in a proteolytic activity-independent way. Plays a role in tissue damage during superficial infection. Moreover, acts toward human hemoglobin though limited proteolysis to generate a variety of antimicrobial hemocidins, enabling to compete with the other microorganisms [...]


ensembl_gene_id: P0CY29
symbol: SAP3
gene_biotype: protein_coding
description:
  Candidapepsin-3; Secreted aspartic peptidases (SAPs) are a group of ten acidic hydrolases considered as key virulence factors. These enzymes supply the fungus with nutrient amino acids as well as are able to degrade the selected host's proteins involved in the immune defense. Induces host inflammatory cytokine production in a proteolytic activity-independent way. Plays a role in tissue damage during superficial infection. Moreover, acts toward human hemoglobin though limited proteolysis to generate a variety of antimicrobial hemocidins, enabling to compete with the other microorganisms [...]


ensembl_gene_id: P0CY31
symbol: SEC4
gene_biotype: protein_coding
description:
  Ras-related protein SEC4; Involved in exocytosis. Maybe by regulating the binding and fusion of secretory vesicles with the cell surface. The GTP-bound form of SEC4 may interact with an effector, thereby stimulating its activity and leading to exocytotic fusion. SEC4 may be an upstream activator of the 19.5S SEC8/SEC15 particle. SEC4 probably interacts directly with SEC8; it could serve as the attachment site for the SEC8/SEC15 particle (By similarity); Belongs to the small GTPase superfamily. Rab family.


ensembl_gene_id: P0CY33
symbol: CDC42
gene_biotype: protein_coding
description:
  Cell division control protein 42 homolog; Involved in hyphal formation, virulence, morphogenesis; Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.


ensembl_gene_id: P0CY34
symbol: TUP1
gene_biotype: protein_coding
description:
  Transcriptional repressor TUP1; Represses transcription by RNA polymerase II. Represses genes responsible for initiating filamentous growth such as HWP1, RBT1, RBT2, RBT4, RBT5, RBT7 and WAP1; and this repression is lifted under inducing environmental conditions. Represses also genes which participate in pathogenesis. Crucial component of the response to farnesol. Plays an important role in the regulation of white-opaque switching.


ensembl_gene_id: P0CY35
symbol: TEF1
gene_biotype: protein_coding
description:
  Elongation factor 1-alpha 1; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.


ensembl_gene_id: P0DJ06
symbol: SAP2
gene_biotype: protein_coding
description:
  Candidapepsin-2; Secreted aspartic peptidases (SAPs) are a group of ten acidic hydrolases considered as key virulence factors. These enzymes supply the fungus with nutrient amino acids as well as are able to degrade the selected host's proteins involved in the immune defense. Induces host inflammatory cytokine production in a proteolytic activity-independent way. Plays a role in tissue damage during superficial infection. Moreover, acts toward human hemoglobin though limited proteolysis to generate a variety of antimicrobial hemocidins, enabling to compete with the other microorganisms [...]


ensembl_gene_id: P10613
symbol: ERG11
gene_biotype: protein_coding
description:
  Lanosterol 14-alpha demethylase; Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'- dimethyl cholesta-8,14,24-triene-3-beta-ol.


ensembl_gene_id: P22011
symbol: CYP1
gene_biotype: protein_coding
description:
  Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.


ensembl_gene_id: P22274
symbol: ARF1
gene_biotype: protein_coding
description:
  ADP-ribosylation factor; GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus; Belongs to the small GTPase superfamily. Arf family.


ensembl_gene_id: P25997
symbol: CEF3
gene_biotype: protein_coding
description:
  Elongation factor 3; The main role of EF-3 may be to transduce nucleoside triphosphate energy into mechanical energy for translocation during translation. EF-3 stimulates EF-1-alpha-dependent binding of aminoacyl- tRNA to the ribosome.


ensembl_gene_id: P28870
symbol: RBP1
gene_biotype: protein_coding
description:
  FK506-binding protein 1; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.


ensembl_gene_id: P29717
symbol: XOG1
gene_biotype: protein_coding
description:
  Glucan 1,3-beta-glucosidase; Major glucan 1,3-beta-glucosidase required for cell wall integrity. Beta-glucanases participate in the metabolism of beta- glucan, the main structural component of the cell wall. Can also function biosynthetically as a transglycosylase. Functions to deliver glucan from the cell to the extracellular matrix. Does not appear to impact cell wall glucan content of biofilm cells, nor is it necessary for filamentation or biofilm formation. Involved in cell-substrate and cell-cell adhesion. Adhesion to host-cell surfaces is the first critical step during mucosal in [...]


ensembl_gene_id: P30418
symbol: NMT1
gene_biotype: protein_coding
description:
  Glycylpeptide N-tetradecanoyltransferase; Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins. Substrate specificity requires an N-terminal glycine in the nascent polypeptide substrates. Ser is present at position 5 in almost all known N-myristoyl proteins and Lys is commonly encountered at postion 6. Basic residues are preferred at positions 7 and 8; Belongs to the NMT family.


ensembl_gene_id: P31353
symbol: PMM1
gene_biotype: protein_coding
description:
  Phosphomannomutase; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions.


ensembl_gene_id: P33181
symbol: SUC1
gene_biotype: protein_coding
description:
  Probable sucrose utilization protein SUC1; Affects sucrose utilization and alpha-glucosidase activity. Probable transcriptional activator; Belongs to the MAL13 family.


ensembl_gene_id: P34948
symbol: PMI1
gene_biotype: protein_coding
description:
  Mannose-6-phosphate isomerase; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions; Belongs to the mannose-6-phosphate isomerase type 1 family.


ensembl_gene_id: P39827
symbol: CDC10
gene_biotype: protein_coding
description:
  Cell division control protein 10; Plays a role in the cell cycle. Involved in the formation of the ring of filaments in the neck region at the mother-bud junction during mitosis.


ensembl_gene_id: P40953
symbol: CHT2
gene_biotype: protein_coding
description:
  Chitinase 2; Chitinase involved in the remodeling of chitin in the fungal cell wall. Plays a role in cell separation.


ensembl_gene_id: P40954
symbol: CHT3
gene_biotype: protein_coding
description:
  Chitinase 3; Chitinase involved in the remodeling of chitin in the fungal cell wall. Plays a role in cell separation.


ensembl_gene_id: P41797
symbol: SSA1
gene_biotype: protein_coding
description:
  Heat shock protein SSA1; May play a role in the transport of polypeptides both across the mitochondrial membranes and into the endoplasmic reticulum.


ensembl_gene_id: P43063
symbol: CDC28
gene_biotype: protein_coding
description:
  Cyclin-dependent kinase 1; Cyclin-dependent kinase essential for the completion of the start, the controlling event, in the cell cycle. Plays a role in the expression of morphology-related transcription factors, and especially hyphae-specific genes. Binds distinct cyclin subunits as cells progress through the division cycle or flamentous growth. The CDC28-CLB2 complex regulates cytokinesis partly by phosphorylating the actomyosin ring component IQG1. The CDC28-CLN3 complex phosphorylates SLA1 which regulates cortical actin patch dynamics. The CDC28-CCN1 complex phosphorylates CDC11 and [...]


ensembl_gene_id: P43065
symbol: LYS1
gene_biotype: protein_coding
description:
  Saccharopine dehydrogenase [NAD(+), L-lysine-forming]; Catalyzes the NAD(+)-dependent cleavage of saccharopine to L- lysine and 2-oxoglutarate, the final step in the alpha-aminoadipate (AAA) pathway for lysin biosynthesis; Belongs to the AlaDH/PNT family.


ensembl_gene_id: P43069
symbol: CDC25
gene_biotype: protein_coding
description:
  Cell division control protein 25; Promotes the exchange of Ras-bound GDP by GTP. This protein positively controls the level of cellular cAMP at start, the stage at which the yeast cell division cycle is triggered.


ensembl_gene_id: P43072
symbol: TDS4
gene_biotype: protein_coding
description:
  Transcription factor IIIB 70 kDa subunit; General activator of RNA polymerase III transcription. Interacts with TBP. Binds to Pol III subunit C34 and to the TAU135 component of TFIIIC.


ensembl_gene_id: P43075
symbol: LIG1
gene_biotype: protein_coding
description:
  tRNA ligase; One of the two proteins required for the splicing of precursor tRNA molecules containing introns. The ligation activity requires three enzymatic activities: phosphorylation of the 5' terminus of the 3' half-tRNA in the presence of ATP, opening of the 2'3'-cyclic phosphodiester bond of the 5' half-tRNA leaving a 2'-phosphomonoester and ligation of the two tRNA halves in an ATP-dependent reaction.


ensembl_gene_id: P43076
symbol: PHR1
gene_biotype: protein_coding
description:
  pH-responsive protein 1; Required for apical cell growth and plays an essential role in morphogenesis. May be integral to the pathogenic ability of the organism.


ensembl_gene_id: P43079
symbol: CPH1
gene_biotype: protein_coding
description:
  Transcription factor CPH1; Transcription factor involved in the formation of pseudohyphae and hyphae. It is likely to play a role in the developmental switch between yeast and mycelial forms. May be involved in a signal transduction system, strengthening the possibility of a sexual phase up to now undetected, and similar to that of the yeast mating pathway.


ensembl_gene_id: P43094
symbol: SAP5
gene_biotype: protein_coding
description:
  Candidapepsin-5; Secreted aspartic peptidases (SAPs) are a group of ten acidic hydrolases considered as key virulence factors. These enzymes supply the fungus with nutrient amino acids as well as are able to degrade the selected host's proteins involved in the immune defense. During infection, plays an important role in penetration into deeper tissues and interaction with host defense. Moreover, acts toward human hemoglobin though limited proteolysis to generate a variety of antimicrobial hemocidins, enabling to compete with the other microorganisms of the same physiological niche usin [...]


ensembl_gene_id: P46250
symbol: SEC14
gene_biotype: protein_coding
description:
  SEC14 cytosolic factor; Required for transport of secretory proteins from the Golgi complex. Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes in vitro (By similarity).


ensembl_gene_id: P46586
symbol: HIS1
gene_biotype: protein_coding
description:
  ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of the enzymatic activity (By similarity).


ensembl_gene_id: P46587
symbol: SSA2
gene_biotype: protein_coding
description:
  Heat shock protein SSA2; May play a role in the transport of polypeptides both across the mitochondrial membranes and into the endoplasmic reticulum.


ensembl_gene_id: P46592
symbol: MNT2
gene_biotype: protein_coding
description:
  Glycolipid 2-alpha-mannosyltransferase 2; Involved in O-glycosylation of cell wall and secreted proteins. Transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D- mannose linkage. Mainly responsible for the addition of the third mannose residue in an O-linked mannose pentamer. Can also substitute for MNT1 by adding the second mannose residue. Important for adherence to host surfaces and for virulence; Belongs to the glycosyltransferase 15 family.


ensembl_gene_id: P46593
symbol: HWP1
gene_biotype: protein_coding
description:
  Hyphal wall protein 1; Major hyphal cell wall protein which plays a role of adhesin and is required for mating, normal hyphal development, cell-to-cell adhesive functions necessary for biofilm integrity, attachment to host, and virulence. Promotes interactions with host and bacterial molecules, thus leading to effective colonization within polymicrobial communities. Plays a crucial role in gastrointestinal colonization, in mucosal symptomatic and asymptomatic infections, in vaginitis, as well as in lethal oroesophageal candidiasis, caused by the combined action of fungal virulence fact [...]


ensembl_gene_id: P46598
symbol: HSP90
gene_biotype: protein_coding
description:
  Heat shock protein 90 homolog; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (By similarity); Belongs to the heat shock protein 90 family.


ensembl_gene_id: P48989
symbol: HTB1
gene_biotype: protein_coding
description:
  Histone H2B.1; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.


ensembl_gene_id: P48990
symbol: TIM54
gene_biotype: protein_coding
description:
  Mitochondrial import inner membrane translocase subunit TIM54; Essential component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin- pore translocase that uses the membrane potential as external driving force (By similarity).


ensembl_gene_id: P52496
symbol: LIG4
gene_biotype: protein_coding
description:
  DNA ligase 4; Involved in ds DNA break (DSB) repair. Has a role in non- homologous integration (NHI) pathways where it is required in the final step of non-homologous end-joining (NHEJ). Not required for the repair of DSBs induced by ionizing radiation or UV light. Has an important role in morphogenesis, positively affecting the capacity to form hyphae.


ensembl_gene_id: P53697
symbol: MNN9
gene_biotype: protein_coding
description:
  Mannan polymerase complex subunit MNN9; Required for the addition of the long alpha 1,6-mannose backbone of N-linked glycans on cell wall and periplasmic proteins.


ensembl_gene_id: P53698
symbol: CYC1
gene_biotype: protein_coding
description:
  Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.


ensembl_gene_id: P53704
symbol: GFA1
gene_biotype: protein_coding
description:
  Glutamine--fructose-6-phosphate aminotransferase [isomerizing]; Involved in amino sugar synthesis (formation of chitin, supplies the amino sugars of asparagine-linked oligosaccharides of glycoproteins).


ensembl_gene_id: P53705
symbol: BUD4
gene_biotype: protein_coding
description:
  Bud site selection protein BUD4; Required for establishment of the axial budding pattern in yeast cells. May be involved in the selection of future sites of septation in hyphal cells. Contributes to morphogenesis and is important for induction of hyphal growth. Also plays a role in epithelial adherence, and is involved in intestinal colonization and systemic infection. The role in adhesion is probably minor compared with its role in morphogenesis. Belongs to the BUD4 family.


ensembl_gene_id: P78595
symbol: CDR2
gene_biotype: protein_coding
description:
  Multidrug resistance protein CDR2; Multidrug efflux transporter. Confers resistance to azole antifungal agents, to other antifungals (terbinafine, amorolfine) and to a variety of metabolic inhibitors; Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.


ensembl_gene_id: P78599
symbol: SPE1
gene_biotype: protein_coding
description:
  Ornithine decarboxylase; Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.


ensembl_gene_id: P79023
symbol: ARO4
gene_biotype: protein_coding
description:
  Phospho-2-dehydro-3-deoxyheptonate aldolase, tyrosine-inhibited; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP); Belongs to the class-I DAHP synthase family.


ensembl_gene_id: P82610
symbol: MET6
gene_biotype: protein_coding
description:
  5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.


ensembl_gene_id: P82611
symbol: ACO1
gene_biotype: protein_coding
description:
  Aconitate hydratase, mitochondrial; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate, a step in the citric acid cycle; Belongs to the aconitase/IPM isomerase family.


ensembl_gene_id: P82612
symbol: GPM1
gene_biotype: protein_coding
description:
  Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily.


ensembl_gene_id: P83773
symbol: ACH1
gene_biotype: protein_coding
description:
  Acetyl-CoA hydrolase; Presumably involved in regulating the intracellular acetyl- CoA pool for fatty acid and cholesterol synthesis and fatty acid oxidation; Belongs to the acetyl-CoA hydrolase/transferase family.


ensembl_gene_id: P83774
symbol: ASC1
gene_biotype: protein_coding
description:
  Guanine nucleotide-binding protein subunit beta-like protein; Located at the head of the 40S ribosomal subunit in the vicinity of the mRNA exit channel, it serves as a scaffold protein that can recruit other proteins to the ribosome. Involved in the negative regulation of translation of a specific subset of proteins (By similarity). Plays a role in morphogenesis and pathogenesis.


ensembl_gene_id: P83775
symbol: GRP2
gene_biotype: protein_coding
description:
  Putative NADPH-dependent methylglyoxal reductase GRP2; Catalyzes the irreversible reduction of the cytotoxic compound methylglyoxal (MG, 2-oxopropanal) to (S)-lactaldehyde. MG is synthesized via a bypath of glycolysis from dihydroxyacetone phosphate and is believed to play a role in cell cycle regulation and stress adaptation; Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.


ensembl_gene_id: P83776
symbol: HXK2
gene_biotype: protein_coding
description:
  Hexokinase-2; Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D- fructose 6-phosphate, respectively). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6- phosphate.


ensembl_gene_id: P83781
symbol: POR1
gene_biotype: protein_coding
description:
  Mitochondrial outer membrane protein porin; Forms a channel through the cell membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective (By similarity); Belongs to the eukaryotic mitochondrial porin family.


ensembl_gene_id: P83782
symbol: QCR2
gene_biotype: protein_coding
description:
  Cytochrome b-c1 complex subunit 2, mitochondrial; Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradie [...]


ensembl_gene_id: P83783
symbol: SAH1
gene_biotype: protein_coding
description:
  Adenosylhomocysteinase; Adenosylhomocysteine is a competitive inhibitor of S- adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.


ensembl_gene_id: P83784
symbol: SSC1
gene_biotype: protein_coding
description:
  Heat shock protein SSC1, mitochondrial; Required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Constitutes the ATP-driven core of the motor and binds the precursor preprotein (By similarity).


ensembl_gene_id: P86029
symbol: HQD2
gene_biotype: protein_coding
description:
  Catechol 1,2-dioxygenase; Can cleave 4-methylcatechol at lower rates than catechol, but has no activity with 3-methylcatechol, 4-chlorocatechol, 4- carboxycatechol or hydroxyquinol.


ensembl_gene_id: P87020
symbol: PRA1
gene_biotype: protein_coding
description:
  pH-regulated antigen PRA1; Cell surface protein involved in the host-parasite interaction during candidal infection. With MP65, represents a major component of the biofilm matrix. Sequesters zinc from host tissue and mediates leukocyte adhesion and migration. As a surface protein, binds the two human complement regulators CFH and CFHR1, as well as plasminogen PLG, mediates complement evasion and extra-cellular matrix interaction and/or degradation. As a released protein, enhances complement control in direct vicinity of the yeast and thus generates an additional protective layer which  [...]


ensembl_gene_id: P87163
symbol: GCD6
gene_biotype: protein_coding
description:
  Translation initiation factor eIF-2B subunit epsilon; Subunit of the guanine nucleotide exchange factor for eIF-2. Belongs to the eIF-2B gamma/epsilon subunits family.


ensembl_gene_id: P87185
symbol: NFS1
gene_biotype: protein_coding
description:
  Cysteine desulfurase, mitochondrial; Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron-sulfur (Fe- S) clusters. Plays a role in both tRNA-processing and mitochondrial metabolism. Involved in the 2-thio-modification of both 5- carboxymethylaminomethyl-2-thiouridine in mitochondrial tRNAs and 5- methoxycarbonylmethyl-2-thiouridine (mcm5s2U) in cytoplasmic tRNAs.


ensembl_gene_id: P87206
symbol: TIF1
gene_biotype: protein_coding
description:
  ATP-dependent RNA helicase eIF4A; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity).


ensembl_gene_id: P87207
symbol: MNT3
gene_biotype: protein_coding
description:
  Probable mannosyltransferase MNT3; Transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D- mannose linkage; Belongs to the glycosyltransferase 15 family.


ensembl_gene_id: P87219
symbol: SOU1
gene_biotype: protein_coding
description:
  Sorbose reductase SOU1; Catalyzes the NADP dependent reduction of L-sorbose to D- glucitol. Can also convert fructose to mannitol, but less efficiently.


ensembl_gene_id: P87220
symbol: VMA8
gene_biotype: protein_coding
description:
  V-type proton ATPase subunit D; Subunit of the peripheral V1 complex of vacuolar ATPase. V- ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (By similarity); Belongs to the V-ATPase D subunit family.


ensembl_gene_id: Q00310
symbol: MNT1
gene_biotype: protein_coding
description:
  Glycolipid 2-alpha-mannosyltransferase 1; Involved in O-glycosylation of cell wall and secreted proteins. Transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D- mannose linkage. Mainly responsible for the addition of the second mannose residue in an O-linked mannose pentamer. Can also substitute for MNT2 by adding the third mannose residue. Important for adherence to host surfaces and for virulence.


ensembl_gene_id: Q04782
symbol: ERG7
gene_biotype: protein_coding
description:
  Lanosterol synthase; Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus.


ensembl_gene_id: Q07730
symbol: ECE1
gene_biotype: protein_coding
description:
  Extent of cell elongation protein 1; Secreted protein involved in biofilm formation. Further cleaved by KEX2 in 8 similar peptides (ECE1- I to ECE1-VIII).


ensembl_gene_id: Q3MNT0
symbol: SPT6
gene_biotype: protein_coding
description:
  Transcription elongation factor SPT6; Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression (By similarity); Belongs to the SPT6 family.


ensembl_gene_id: Q59JU3
symbol: IPI1
gene_biotype: protein_coding
description:
  Pre-rRNA-processing protein IPI1-1; Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.


ensembl_gene_id: Q59K07
symbol: EAF3
gene_biotype: protein_coding
description:
  Chromatin modification-related protein EAF3; Involved in deacetylation of histones, chromatin assembly and chromosome segregation. May act as a transcriptional oscillator, directing histone deacetylases to specific chromosomal domains. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity).


ensembl_gene_id: Q59K86
symbol: BNA1
gene_biotype: protein_coding
description:
  3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.


ensembl_gene_id: Q59KC4
symbol: CaO19.1804
gene_biotype: protein_coding
description:
  Mitochondrial glycine transporter; Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix; Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.


ensembl_gene_id: Q59KF3
symbol: SPB1
gene_biotype: protein_coding
description:
  AdoMet-dependent rRNA methyltransferase SPB1; Required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.


ensembl_gene_id: Q59KG2
symbol: RGI1
gene_biotype: protein_coding
description:
  Respiratory growth induced protein 1; Involved in the control of energetic metabolism and significantly contribute to cell fitness, especially under respiratory growth conditions.


ensembl_gene_id: Q59KI0
symbol: UGP1
gene_biotype: protein_coding
description:
  UTP--glucose-1-phosphate uridylyltransferase; Plays a central role as a glucosyl donor in cellular metabolic pathways; Belongs to the UDPGP type 1 family.


ensembl_gene_id: Q59KI4
symbol: INO80
gene_biotype: protein_coding
description:
  Chromatin-remodeling ATPase INO80; ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.


ensembl_gene_id: Q59KJ7
symbol: MNN21
gene_biotype: protein_coding
description:
  Alpha-1,2-mannosyltransferase MNN21; Alpha-1,2-mannosyltransferase required for cell wall integrity. Responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides. Addition of alpha-1,2-mannose is required for stabilization of the alpha-1,6-mannose backbone and hence regulates mannan fibril length; and is important for both immune recognition and virulence.


ensembl_gene_id: Q59KL6
symbol: PZF1
gene_biotype: protein_coding
description:
  Transcription factor IIIA; Transcription factor required for transcription of 5S rRNA by RNA polymerase III.


ensembl_gene_id: Q59KM8
symbol: DBF2
gene_biotype: protein_coding
description:
  Cell cycle protein kinase DBF2; Ser/Thr-protein kinase involved in the mitotic exit network (MEN) and required after the metaphase to anaphase cell cycle transition. Required for proper nuclear segregation, mitotic spindle organization, actomyosin ring contraction, primary septum assembly, and normal hyphal morphogenesis.


ensembl_gene_id: Q59KN8
symbol: IPK1
gene_biotype: protein_coding
description:
  Inositol-pentakisphosphate 2-kinase; Has kinase activity and phosphorylates inositol-1,3,4,5,6- pentakisphosphate (Ins(1,3,4,5,6)P5) to produce 1,2,3,4,5,6- hexakisphosphate (InsP6), also known as phytate; Belongs to the IPK1 type 1 family.


ensembl_gene_id: Q59KY8
symbol: SIT4
gene_biotype: protein_coding
description:
  Serine/threonine-protein phosphatase SIT4; Serine/threonine protein phosphatase which is involved in the dephosphorylation of the large subunit of RNA polymerase II. Is required in late G1 for normal G1 cyclin expression, bud initiation and expression of certain genes that are periodically expressed during late G1 (By similarity). Plays a role during hyphal growth through the regulation of cell wall biogenesis, osmosensing and protein translation. Involved in virulence in a mouse systemic infection model.


ensembl_gene_id: Q59KZ1
symbol: APE2
gene_biotype: protein_coding
description:
  Aminopeptidase 2; Metalloprotease that specifically hydrolyzes peptides with N- terminal alanine, arginine and leucine residues.


ensembl_gene_id: Q59KZ3
symbol: URA6
gene_biotype: protein_coding
description:
  Uridylate kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and dUMP as phosphate acceptors, but can also use CMP, dCMP and AMP. Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.


ensembl_gene_id: Q59L12
symbol: ALS3
gene_biotype: protein_coding
description:
  Agglutinin-like protein 3; Cell surface adhesion protein which mediates both yeast-to- host tissue adherence and yeast aggregation. Plays an important role in the biofilm formation and pathogenesis of C.albicans infections. Necessary for C.albicans to bind to N-cadherin on endothelial cells and E-cadherin on oral epithelial cells and subsequent endocytosis by these cells. During disseminated infection, mediates initial trafficking to the brain and renal cortex and contributes to fungal persistence in the kidneys. Belongs to the ALS family.


ensembl_gene_id: Q59L13
symbol: TIF6
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export; Belongs to the eIF-6 family.


ensembl_gene_id: Q59L86
symbol: PGA25
gene_biotype: protein_coding
description:
  Probable GPI-anchored adhesin-like protein PGA25; Probable GPI-anchored cell wall protein involved in cell wall organization, hyphal growth, as well as in host-fungal interaction and virulence; Belongs to the HYR1/IFF family.


ensembl_gene_id: Q59L89
symbol: SDH7
gene_biotype: protein_coding
description:
  Succinate dehydrogenase assembly factor 3, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.


ensembl_gene_id: Q59L96
symbol: PGA48
gene_biotype: protein_coding
description:
  Cell wall protein PGA48; Cell wall protein that plays a role in adaptation and resistance to cell wall stress; Belongs to the SED1 family.


ensembl_gene_id: Q59LC9
symbol: YAF9
gene_biotype: protein_coding
description:
  Protein AF-9 homolog; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4 and H2A. The NuA4 complex is also involved in DNA repair. Yaf9 may also be required for viability in conditions in which the structural integrity of the spindle is compromised (By similarity).


ensembl_gene_id: Q59LF2
symbol: ALG2
gene_biotype: protein_coding
description:
  Alpha-1,3/1,6-mannosyltransferase ALG2; Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.


ensembl_gene_id: Q59LF3
symbol: RVS167
gene_biotype: protein_coding
description:
  Regulator of cytoskeleton and endocytosis RVS167; Component of a cytoskeletal structure that is required for the formation of endocytic vesicles at the plasma membrane level. Plays an important role in virulence.


ensembl_gene_id: Q59LF9
symbol: MAP2
gene_biotype: protein_coding
description:
  Methionine aminopeptidase 2; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val); Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.


ensembl_gene_id: Q59LI2
symbol: TIM17
gene_biotype: protein_coding
description:
  Mitochondrial import inner membrane translocase subunit TIM17; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.


ensembl_gene_id: Q59LL4
symbol: MDM10
gene_biotype: protein_coding
description:
  Mitochondrial distribution and morphology protein 10; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. MDM10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex). Functions in the TOM40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of TOM40 with the recepto [...]


ensembl_gene_id: Q59LL5
symbol: HIS3
gene_biotype: protein_coding
description:
  Imidazoleglycerol-phosphate dehydratase; Belongs to the imidazoleglycerol-phosphate dehydratase family.


ensembl_gene_id: Q59LN9
symbol: CSE4
gene_biotype: protein_coding
description:
  Histone H3-like centromeric protein CSE4; Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division (By similarity).


ensembl_gene_id: Q59LQ4
symbol: CKS1
gene_biotype: protein_coding
description:
  Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.


ensembl_gene_id: Q59LR2
symbol: MEC1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase MEC1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Recruited to DNA lesions in order to initiate the DNA repair by homologous recombination. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, also involved in the regulation of DNA damage response mechanism. Required for cell growth and meiotic recombina [...]


ensembl_gene_id: Q59LU0
symbol: DBP2
gene_biotype: protein_coding
description:
  ATP-dependent RNA helicase DBP2; ATP-dependent RNA helicase involved nonsense-mediated mRNA decay and ribosome biogenesis through rRNA processing.


ensembl_gene_id: Q59LV5
symbol: CHO2
gene_biotype: protein_coding
description:
  Phosphatidylethanolamine N-methyltransferase; Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME); Belongs to the class VI-like SAM-binding methyltransferase superfamily. CHO2 family.


ensembl_gene_id: Q59LV8
symbol: ASG1
gene_biotype: protein_coding
description:
  Activator of stress genes protein 1; Transcription factor necessary to sustain growth on non- fermentative carbon sources such as sodium acetate, acetic acid, or ethanol. Plays a role in hyphal formation.


ensembl_gene_id: Q59LX5
symbol: TRY2
gene_biotype: protein_coding
description:
  Transcriptional regulator of yeast form adherence 2; Transcription factor required for yeast cell adherence to silicone substrate.


ensembl_gene_id: Q59LX9
symbol: BTN1
gene_biotype: protein_coding
description:
  Protein BTN1; Involved in vacuolar transport and vacuole pH homeostasis. Also required for cytokinesis (By similarity); Belongs to the battenin family.


ensembl_gene_id: Q59LY1
symbol: BRG1
gene_biotype: protein_coding
description:
  Biofilm regulator 1; Transcription factor required for hyphal growth, biofilm formation, and virulence. Promotes formation of both conventional and pheromone-stimulated biofilms. Binds and recruits HDA1 to promoters of hypha-specific genes in a rapamycin-dependent manner. Involved in the switch between two heritable states, the white and opaque states. These two cell types differ in many characteristics, including cell structure, mating competence, and virulence. Each state is heritable for many generations, and switching between states occurs stochastically at low frequency.


ensembl_gene_id: Q59M00
symbol: EPT1
gene_biotype: protein_coding
description:
  Bifunctional diacylglycerol cholinephosphotransferase/ethanolaminephosphotransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.


ensembl_gene_id: Q59M53
symbol: CaO19.5846
gene_biotype: protein_coding
description:
  RNA polymerase II transcription factor B subunit 2; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family.


ensembl_gene_id: Q59M69
symbol: CaO19.3508
gene_biotype: protein_coding
description:
  ATP-dependent (S)-NAD(P)H-hydrate dehydratase; Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.


ensembl_gene_id: Q59M70
symbol: MCR1
gene_biotype: protein_coding
description:
  NADH-cytochrome b5 reductase 2; May mediate the reduction of outer membrane cytochrome b5. Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.


ensembl_gene_id: Q59MA3
symbol: PSF2
gene_biotype: protein_coding
description:
  DNA replication complex GINS protein PSF2; The GINS complex plays an essential role in the initiation of DNA replication. Has a role in chromosome segregation (By similarity).


ensembl_gene_id: Q59MA6
symbol: RHD1
gene_biotype: protein_coding
description:
  Beta-mannosyltransferase 2; Beta-mannosyltransferase involved in cell wall biosynthesis. Required for the addition of beta-mannose to the acid-labile fraction of cell wall phosphopeptidomannan; Belongs to the BMT family.


ensembl_gene_id: Q59MA9
symbol: CLU1
gene_biotype: protein_coding
description:
  Clustered mitochondria protein homolog; mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.


ensembl_gene_id: Q59MB6
symbol: ARG2
gene_biotype: protein_coding
description:
  Amino-acid acetyltransferase, mitochondrial; N-acetylglutamate synthase involved in arginine biosynthesis.


ensembl_gene_id: Q59MC8
symbol: MDM34
gene_biotype: protein_coding
description:
  Mitochondrial distribution and morphology protein 34; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10.


ensembl_gene_id: Q59MD0
symbol: PGA50
gene_biotype: protein_coding
description:
  Probable cell wall protein PGA50; Probable GPI-anchored cell wall protein that may be involved in cell wall organization, hyphal growth, as well as in virulence.


ensembl_gene_id: Q59MD2
symbol: UME6
gene_biotype: protein_coding
description:
  Transcriptional regulatory protein UME6; Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). UME6 controls the level and duration of gene expression in the filamentous growth program such as HGC1; and is specifically important for hyphal elongation and germ tube formation. Promo [...]


ensembl_gene_id: Q59MF9
symbol: COG6
gene_biotype: protein_coding
description:
  Conserved oligomeric Golgi complex subunit 6; Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events (By similarity); Belongs to the COG6 family.


ensembl_gene_id: Q59MG1
symbol: DPH1
gene_biotype: protein_coding
description:
  2-(3-amino-3-carboxypropyl)histidine synthase subunit 1; Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2. Belongs to the DPH1/DPH2 family. DPH1 subfamily.


ensembl_gene_id: Q59MI8
symbol: TIM8
gene_biotype: protein_coding
description:
  Mitochondrial import inner membrane translocase subunit TIM8; Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIM8- TIM13 complex is non essential and only mediates  [...]


ensembl_gene_id: Q59MJ1
symbol: MRR2
gene_biotype: protein_coding
description:
  Multidrug resistance regulator 2; Transcription factor that controls the expression of CDR1, the major multidrug efflux pump. Required for yeast cell adherence to silicone substrate and plays a role in virulence.


ensembl_gene_id: Q59MN0
symbol: VAC8
gene_biotype: protein_coding
description:
  Vacuolar protein 8; Functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole. Vacuole inheritance has a role in the regulation of hyphal cell division; Belongs to the beta-catenin family.


ensembl_gene_id: Q59MP1
symbol: NBP35
gene_biotype: protein_coding
description:
  Cytosolic Fe-S cluster assembly factor NBP35; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Required for biogenesis and export of both ribosomal subunits, which may reflect a role in assembly of the Fe/S clusters in RLI1, a protein which performs rRNA processing and ribosome export; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NB [...]


ensembl_gene_id: Q59MQ0
symbol: MYO5
gene_biotype: protein_coding
description:
  Myosin-5; Type-I myosin implicated in the organization of the actin cytoskeleton. Required for proper actin cytoskeleton polarization and for the internalization step in endocytosis. At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly. Functions as actin nucleation-promoting factor (NPF) for the Arp2/3 complex (By similarity). Plays a role in chitin deposition in the cell wall, in determination of the budding pattern, and is required for hyphae formation.


ensembl_gene_id: Q59MU1
symbol: UTP25
gene_biotype: protein_coding
description:
  U3 small nucleolar RNA-associated protein 25; DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.


ensembl_gene_id: Q59MV1
symbol: ASF1
gene_biotype: protein_coding
description:
  Histone chaperone ASF1; Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly.


ensembl_gene_id: Q59MV9
symbol: YHB1
gene_biotype: protein_coding
description:
  Flavohemoprotein; Nitric oxide dioxygenase involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the fungus from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress. Plays a role in virulence since nitric oxide is generated by macrophages of the host immune system. Belongs to the globin family.


ensembl_gene_id: Q59MW2
symbol: DBP6
gene_biotype: protein_coding
description:
  ATP-dependent RNA helicase DBP6; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.


ensembl_gene_id: Q59MZ8
symbol: RPB8
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.


ensembl_gene_id: Q59MZ9
symbol: MNT4
gene_biotype: protein_coding
description:
  Putative alpha-1,3-mannosyltransferase MNT4; Responsible for addition of the terminal mannose residues to the outer chain of core N-linked polysaccharides and to O-linked mannotriose. Implicated in late Golgi modifications (By similarity). Belongs to the MNN1/MNT family.


ensembl_gene_id: Q59N20
symbol: MSS11
gene_biotype: protein_coding
description:
  Transcription activator MSS11; Transcription factor that regulates pseudohyphal differentiation, invasive growth, floculation, adhesion and starch metabolism in response to nutrient availability.


ensembl_gene_id: Q59N29
symbol: SPB4
gene_biotype: protein_coding
description:
  ATP-dependent rRNA helicase SPB4; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.


ensembl_gene_id: Q59N31
symbol: VPS22
gene_biotype: protein_coding
description:
  Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family.


ensembl_gene_id: Q59N74
symbol: RCF1
gene_biotype: protein_coding
description:
  Respiratory supercomplex factor 1, mitochondrial; Cytochrome c oxidase subunit which plays a role in assembly of respiratory supercomplexes.


ensembl_gene_id: Q59N80
symbol: HAM1
gene_biotype: protein_coding
description:
  Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.


ensembl_gene_id: Q59NB8
symbol: LKH1
gene_biotype: protein_coding
description:
  Leucine aminopeptidase 2; Aminopeptidase that preferentially cleaves di- and tripeptides. Also has low epoxide hydrolase activity (in vitro). Can hydrolyze the epoxide leukotriene LTA(4) but it forms preferentially 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid rather than the cytokine leukotriene B(4) as the product compared to the homologous mammalian enzyme (in vitro).


ensembl_gene_id: Q59NG5
symbol: MUS81
gene_biotype: protein_coding
description:
  Crossover junction endonuclease MUS81; Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single- end invasion (SEI) (By similarity); Belongs to the XPF family.


ensembl_gene_id: Q59NG8
symbol: NHX1
gene_biotype: protein_coding
description:
  Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.


ensembl_gene_id: Q59NH8
symbol: CDC14
gene_biotype: protein_coding
description:
  Tyrosine-protein phosphatase CDC14; Protein phosphatase which antagonizes mitotic cyclin- dependent kinase CDC28, the inactivation of which is essential for exit from mitosis. To access its substrates, is released from nucleolar sequestration during mitosis. Plays an essential in coordinating the nuclear division cycle with cytokinesis through the cytokinesis checkpoint. Involved in chromosome segregation, where it is required for meiosis I spindle dissambly as well as for establishing two consecutive chromosome segregation phases (By similarity). Plays a role in the expression of hydr [...]


ensembl_gene_id: Q59NN8
symbol: FES1
gene_biotype: protein_coding
description:
  Hsp70 nucleotide exchange factor FES1; Functions as a nucleotide exchange factor (NEF) for Hsp70 chaperones which accelerates the release of ADP. Required for fully efficient Hsp70-mediated folding of proteins (By similarity). Belongs to the FES1 family.


ensembl_gene_id: Q59NP1
symbol: CTR1
gene_biotype: protein_coding
description:
  Copper transport protein CTR1; Required for high affinity copper (probably reduced Cu I) transport into the cell.


ensembl_gene_id: Q59NP5
symbol: SUN41
gene_biotype: protein_coding
description:
  Secreted beta-glucosidase SUN41; Cell surface beta-glucosidase involved in cytokinesis, cell wall biogenesis, adhesion to host tissue, and biofilm formation; thus playing an important role in the host-pathogen interaction. Has hydrolytic activity on linear (1->3)-beta-D-glucans such as laminaribiose and other laminarioligosaccharides. Belongs to the SUN family.


ensembl_gene_id: Q59NQ5
symbol: GLR1
gene_biotype: protein_coding
description:
  Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.


ensembl_gene_id: Q59NQ9
symbol: FYV7
gene_biotype: protein_coding
description:
  rRNA-processing protein FYV7; Involved in the processing of the 20S pre-rRNA. Belongs to the FYV7 family.


ensembl_gene_id: Q59NW5
symbol: YBL053
gene_biotype: protein_coding
description:
  Topoisomerase 1-associated factor 1; Forms a fork protection complex (FPC) with CSM3 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors (By similarity).


ensembl_gene_id: Q59NX5
symbol: FGR27
gene_biotype: protein_coding
description:
  Filamentous growth regulator 27; Transcription factor involved in yeast cell adherence to silicone substrate, filamentous growth, and biofilm formation.


ensembl_gene_id: Q59NX9
symbol: DPH5
gene_biotype: protein_coding
description:
  Diphthine methyl ester synthase 1; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.


ensembl_gene_id: Q59NY7
symbol: CUE1
gene_biotype: protein_coding
description:
  Coupling of ubiquitin conjugation to ER degradation protein 1; Component of the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Recruits the soluble ubiquitin-conjugating enzyme UBC7 to the cytoplasmic face of the endoplasmic reticulum membrane where it functions in degradation of misfolded or regulated proteins localized in the endoplasmic reticulum (ER) lumen or membrane via the ubiquitin-proteasome system. Targets the E2 conjugating enzyme UBC7 to the DOA10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of mem [...]


ensembl_gene_id: Q59P03
symbol: CBR1
gene_biotype: protein_coding
description:
  NADH-cytochrome b5 reductase 1; Electron donor reductase for cytochrome b5. The cytochrome b5/NADH cytochrome b5 reductase electron transfer system supports the catalytic activity of several sterol biosynthetic enzymes (By similarity).


ensembl_gene_id: Q59P11
symbol: HSV2
gene_biotype: protein_coding
description:
  SVP1-like protein 2; Involved in mitochondrial or peroxisomal functions and amino acid signaling pathways.


ensembl_gene_id: Q59P39
symbol: EFH1
gene_biotype: protein_coding
description:
  Transcriptional regulator EFH1; Transcription factor that regulates filamentous growth through repression of EFG1. Regulates the level of colonizing fungi, favoring commensalism as opposed to candidiasis.


ensembl_gene_id: Q59P43
symbol: GSP1
gene_biotype: protein_coding
description:
  GTP-binding nuclear protein; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family.


ensembl_gene_id: Q59P44
symbol: YHC1
gene_biotype: protein_coding
description:
  U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.


ensembl_gene_id: Q59P50
symbol: YSH1
gene_biotype: protein_coding
description:
  Endoribonuclease YSH1; Component of the cleavage factor I (CF I) involved in pre- mRNA 3'-end processing; Belongs to the metallo-beta-lactamase superfamily. RNA- metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.


ensembl_gene_id: Q59P53
symbol: GUF1
gene_biotype: protein_coding
description:
  Translation factor GUF1, mitochondrial; Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.


ensembl_gene_id: Q59P87
symbol: SOH1
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 31; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).


ensembl_gene_id: Q59P96
symbol: IRC6
gene_biotype: protein_coding
description:
  Increased recombination centers protein 6; Involved in gross chromosomal rearrangements (GCRs) and telomere healing.


ensembl_gene_id: Q59PD6
symbol: MAD1
gene_biotype: protein_coding
description:
  Spindle assembly checkpoint component MAD1; Central component of the spindle assembly checkpoint which is a feedback control that prevents cells with incompletely assembled spindles from leaving mitosis.


ensembl_gene_id: Q59PE4
symbol: RVS162
gene_biotype: protein_coding
description:
  RVS161-like protein RVS162; Component of a cytoskeletal structure that is required for membrane curvature.


ensembl_gene_id: Q59PE7
symbol: BCP1
gene_biotype: protein_coding
description:
  Protein BCP1; Involved in nuclear export, actin cytoskeleton organization and vesicular transport; Belongs to the BCP1 family.


ensembl_gene_id: Q59PF9
symbol: HWP2
gene_biotype: protein_coding
description:
  Hyphal wall protein 2; GPI-anchored cell wall protein required for mating efficiency, biofilm formation, adhesion, filamentous growth, and oxidative stress tolerance. Involved in normal disseminated infection in a mouse systemic candidiasis model.


ensembl_gene_id: Q59PG6
symbol: JAB1
gene_biotype: protein_coding
description:
  COP9 signalosome complex subunit 5; Catalytic Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes; Belongs to the peptidase M67A family. CSN5 subfamily.


ensembl_gene_id: Q59PL9
symbol: RPG1A
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 3 subunit A; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.


ensembl_gene_id: Q59PP0
symbol: HSM3
gene_biotype: protein_coding
description:
  DNA mismatch repair protein HSM3; Involved in DNA mismatch repair in slow-growing cells. Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the 19S regulatory complex (RC) (By similarity); Belongs to the proteasome subunit S5B/HSM3 family.


ensembl_gene_id: Q59PP6
symbol: SIN4
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 16; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).


ensembl_gene_id: Q59PR3
symbol: DBP8
gene_biotype: protein_coding
description:
  ATP-dependent RNA helicase DBP8; ATP-binding RNA helicase involved in 40S ribosomal subunit biogenesis and is required for the normal formation of 18S rRNAs through pre-rRNA processing at A0, A1 and A2 sites. Required for vegetative growth (By similarity); Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily.


ensembl_gene_id: Q59PR7
symbol: SDA1
gene_biotype: protein_coding
description:
  Protein SDA1; Required for 60S pre-ribosomal subunits export to the cytoplasm; Belongs to the SDA1 family.


ensembl_gene_id: Q59PR9
symbol: HMO1
gene_biotype: protein_coding
description:
  Transcriptional regulator HMO1; Transcription factor that binds upstream of hexose and ergosterol metabolism, as well as cell cycle genes. Activates pseudohyphal growth.


ensembl_gene_id: Q59PT0
symbol: VMA2
gene_biotype: protein_coding
description:
  V-type proton ATPase subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. It is an electrogenic proton pump that generates a proton motive force, inside positive and acidic, in the vacuolar membrane vesicles (By similarity). Plays an important role in resistance to several stresses, as well as in autophagy and virulence; Belongs to the ATPase alpha/beta chains family.


ensembl_gene_id: Q59PT4
symbol: LCL2
gene_biotype: protein_coding
description:
  Long chronological lifespan protein 2; Probable component of the endoplasmic reticulum-associated degradation (ERAD) pathway.


ensembl_gene_id: Q59PT6
symbol: SPC25
gene_biotype: protein_coding
description:
  Probable kinetochore protein SPC25; Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.


ensembl_gene_id: Q59PU1
symbol: CaO19.6623
gene_biotype: protein_coding
description:
  Transcription elongation factor 1 homolog; Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions. Belongs to the ELOF1 family.


ensembl_gene_id: Q59PU4
symbol: GPI8
gene_biotype: protein_coding
description:
  GPI-anchor transamidase; Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein. Belongs to the peptidase C13 family.


ensembl_gene_id: Q59PV8
symbol: ATP7
gene_biotype: protein_coding
description:
  ATP synthase subunit d, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the cent [...]


ensembl_gene_id: Q59PW0
symbol: PIR32
gene_biotype: protein_coding
description:
  Probable cell wall mannoprotein PIR32; Probable structural component of the cell wall involved in cell wall integrity and virulence.


ensembl_gene_id: Q59PZ3
symbol: APG7
gene_biotype: protein_coding
description:
  Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy wh [...]


ensembl_gene_id: Q59PZ4
symbol: NMD3
gene_biotype: protein_coding
description:
  60S ribosomal export protein NMD3; Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit; Belongs to the NMD3 family.


ensembl_gene_id: Q59PZ6
symbol: SOL3
gene_biotype: protein_coding
description:
  6-phosphogluconolactonase-like protein; Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.


ensembl_gene_id: Q59PZ7
symbol: CPD1
gene_biotype: protein_coding
description:
  2',3'-cyclic-nucleotide 3'-phosphodiesterase; Involved in the metabolism of ADP-ribose 1',2'-cyclic phosphate which is produced as a consequence of tRNA splicing.


ensembl_gene_id: Q59Q30
symbol: GIT1
gene_biotype: protein_coding
description:
  Glycerophosphoinositol permease 1; Glycerophosphodiester transporter that mediates uptake of glycerophosphoinositol (GroPIns) as a source of inositol and phosphate. Does not possess detectable glycerophosphocholine (GroPCho) transport activity. Although no glycerophosphoinositol transport activity occurs in the absence of GIT1, C.albicans is still able to use glycerophosphoinositol as a phosphate source at pH 7.5, albeit slowly. Thus, a second, GIT1-independent, mechanism must exist for utilizing glycerophosphoinositol as a phosphate source at physiological pH. The expanded ability to  [...]


ensembl_gene_id: Q59Q36
symbol: TPC1
gene_biotype: protein_coding
description:
  Mitochondrial thiamine pyrophosphate carrier 1; Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria; Belongs to the mitochondrial carrier (TC 2.A.29) family.


ensembl_gene_id: Q59Q38
symbol: PNG1
gene_biotype: protein_coding
description:
  Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase; Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins [...]


ensembl_gene_id: Q59Q39
symbol: TRM10
gene_biotype: protein_coding
description:
  tRNA (guanine(9)-N1)-methyltransferase; S-adenosyl-L-methionine-dependent guanine N(1)- methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in cytoplasmic tRNA; Belongs to the class IV-like SAM-binding methyltransferase superfamily. TRM10 family.


ensembl_gene_id: Q59Q43
symbol: SYM1
gene_biotype: protein_coding
description:
  Protein SYM1; May be involved in cellular response to stress. Required to maintain mitochondrial DNA (mtDNA) integrity and stability (By similarity); Belongs to the peroxisomal membrane protein PXMP2/4 family.


ensembl_gene_id: Q59Q44
symbol: RTS1
gene_biotype: protein_coding
description:
  Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.


ensembl_gene_id: Q59Q46
symbol: IMH3
gene_biotype: protein_coding
description:
  Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.


ensembl_gene_id: Q59Q77
symbol: CaO19.4412
gene_biotype: protein_coding
description:
  DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family.


ensembl_gene_id: Q59Q79
symbol: ALG1
gene_biotype: protein_coding
description:
  Chitobiosyldiphosphodolichol beta-mannosyltransferase; Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER (By similarity); Belongs to the glycosyltransferase group 1 family.


ensembl_gene_id: Q59QB4
symbol: VCX1
gene_biotype: protein_coding
description:
  Vacuolar calcium ion transporter; Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.


ensembl_gene_id: Q59QC2
symbol: EAF6
gene_biotype: protein_coding
description:
  Chromatin modification-related protein EAF6; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity).


ensembl_gene_id: Q59QC4
symbol: BNA5
gene_biotype: protein_coding
description:
  Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.


ensembl_gene_id: Q59QC5
symbol: APS3
gene_biotype: protein_coding
description:
  Clathrin-associated protein AP-3 complex component APS3; Part of the AP-3 complex, an adapter-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane (By similarity). Involved in vacuolar trafficking and contributes to hyphal growth and pathogenesis.


ensembl_gene_id: Q59QC6
symbol: CBP4
gene_biotype: protein_coding
description:
  Assembly factor CBP4; Essential for the assembly of ubiquinol-cytochrome c reductase. It has a direct effect on the correct occurrence of the Rieske protein, core 4, core 5 and apocytochrome b (By similarity). Belongs to the CBP4 family.


ensembl_gene_id: Q59QC7
symbol: UPC2
gene_biotype: protein_coding
description:
  Sterol uptake control protein 2; Transcription factor involved in the regulation of ergosterol biosynthetic genes such as ERG2 and ERG11 through direct binding to sterol response elements (SREs) in the promoters. Binds also to its own promoter on 2 cis-acting elements to promote autoregulation. Regulates sterol uptake across the plasma membrane. Acts as a major regulator of ascorbic acid-induced response. Plays a role in the triggering of pyroptosis, an inflammasome-mediated programmed cell death pathway in macrophages, allowing macrophages escaping.


ensembl_gene_id: Q59QD6
symbol: TEF2
gene_biotype: protein_coding
description:
  Elongation factor 1-alpha 2; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.


ensembl_gene_id: Q59QH0
symbol: NOP9
gene_biotype: protein_coding
description:
  Nucleolar protein 9; RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit (By similarity); Belongs to the NOP9 family.


ensembl_gene_id: Q59QH6
symbol: SPC19
gene_biotype: protein_coding
description:
  DASH complex subunit SPC19; Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity).


ensembl_gene_id: Q59QL0
symbol: ERF2
gene_biotype: protein_coding
description:
  Palmitoyltransferase ERF2; The ERF2-ERF4 complex is a palmitoyltransferase specific for Ras proteins; Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.


ensembl_gene_id: Q59QN7
symbol: SDH2
gene_biotype: protein_coding
description:
  Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).


ensembl_gene_id: Q59QT6
symbol: CaO19.2637
gene_biotype: protein_coding
description:
  Post-GPI attachment to proteins factor 3; Involved in the lipid remodeling steps of GPI-anchor maturation; Belongs to the PGAP3 family.


ensembl_gene_id: Q59QW5
symbol: FLO8
gene_biotype: protein_coding
description:
  Transcriptional regulator of filamentous growth FLO8; Transcription factor which mediates CO(2) sensing. Required for CO(2)-induced white-to-opaque switching, as well as for filamentous growth and virulence. Required for both normoxic and hypoxic biofilm formation. Hypoxic biofilm formation is a major cause of perseverance and antifungal resistance during infections.


ensembl_gene_id: Q59R09
symbol: ATM1
gene_biotype: protein_coding
description:
  Iron-sulfur clusters transporter ATM1, mitochondrial; Performs an essential function in the generation of cytoplasmic iron-sulfur proteins by mediating the ATP-dependent export of Fe/S cluster precursors synthesized by NFS1 and other mitochondrial proteins. Hydrolyzes ATP. Binds glutathione and may function by transporting a glutathione-conjugated iron-sulfur compound (By similarity).


ensembl_gene_id: Q59R24
symbol: TIM9
gene_biotype: protein_coding
description:
  Mitochondrial import inner membrane translocase subunit TIM9; Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta- barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity); Belongs to the small Tim family.


ensembl_gene_id: Q59R28
symbol: MNN26
gene_biotype: protein_coding
description:
  Alpha-1,2-mannosyltransferase MNN26; Alpha-1,2-mannosyltransferase required for cell wall integrity. Responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides. Addition of alpha-1,2-mannose is required for stabilization of the alpha-1,6-mannose backbone and hence regulates mannan fibril length; and is important for both immune recognition and virulence; Belongs to the MNN1/MNT family.


ensembl_gene_id: Q59R32
symbol: CaO19.6688
gene_biotype: protein_coding
description:
  Virulence factor CaO19.6688; Virulence factor involved in pathogen-host interaction. Modulates host proinflammatory cytokine interleukin-1 beta (IL1B) expression.


ensembl_gene_id: Q59RA0
symbol: RIX1
gene_biotype: protein_coding
description:
  Pre-rRNA-processing protein RIX1; Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA and the nucleoplasmic transit of the pre- 60S ribosomal subunits. Regulates pre-60S association of the critical remodeling factor MDN1.


ensembl_gene_id: Q59RG0
symbol: NAG4
gene_biotype: protein_coding
description:
  Major facilitator superfamily multidrug transporter NAG4; MFS transporter involved in N-acetylglucosamine (GlcNAc) uptake. Confers resistance to cycloheximide, 4- nitroquinoline-N-oxide, and 1,10-phenanthroline, and contributes to virulence. Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.


ensembl_gene_id: Q59RH5
symbol: HAT2
gene_biotype: protein_coding
description:
  Histone acetyltransferase type B subunit 2; Regulatory subunit of the histone acetylase B (HAT-B) complex. The complex acetylates 'Lys-14' of histone H4 which is required for telomeric silencing.


ensembl_gene_id: Q59RK9
symbol: OCT1
gene_biotype: protein_coding
description:
  Mitochondrial intermediate peptidase; Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity).


ensembl_gene_id: Q59RL7
symbol: CPH2
gene_biotype: protein_coding
description:
  Transcription factor CPH2; Transcription factor that positively controls filamentous growth, virulence, and invasiveness. Binds directly to the two SRE-1- like elements upstream of TEC1 and thus regulates positively expression of this important hyphal growth regulator. Functions independently of known signaling cascades involving EFG1. Regulates also gene expression during intestinal colonization but is not involved in host cell adhesion.


ensembl_gene_id: Q59RN2
symbol: ARC15
gene_biotype: protein_coding
description:
  Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.


ensembl_gene_id: Q59RN6
symbol: CHZ1
gene_biotype: protein_coding
description:
  Histone H2A.Z-specific chaperone CHZ1; Forms a chaperone-bound H2A.Z-H2B complex that acts as a source for SWR1 complex-dependent H2A to H2A.Z histone replacement in chromatin.


ensembl_gene_id: Q59RP1
symbol: CaO19.6142
gene_biotype: protein_coding
description:
  Meiotic nuclear division protein 1; Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. Belongs to the MND1 family.


ensembl_gene_id: Q59RQ0
symbol: PIF1
gene_biotype: protein_coding
description:
  ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...]


ensembl_gene_id: Q59RQ1
symbol: CaO19.6132
gene_biotype: protein_coding
description:
  MICOS complex subunit MIC12; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.


ensembl_gene_id: Q59RQ2
symbol: KSR1
gene_biotype: protein_coding
description:
  3-ketodihydrosphingosine reductase TSC10; Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS); Belongs to the short-chain dehydrogenases/reductases (SDR) family.


ensembl_gene_id: Q59RR0
symbol: ACE2
gene_biotype: protein_coding
description:
  Cell wall transcription factor ACE2; Transcription factor involved in the RAM (regulation of ACE2 transcription factor and polarized morphogenesis) signaling network that regulates polarized morphogenesis. Regulates expression of genes involved in cell separation such as CHT3, DSE1, and SCW11; or other cell wall genes such as ASH1, DSE4, PIR1, PRY2, and RME1. Required for regulation of morphogenesis, cell separation, adherence, biofilm formation, invasion, as well as virulence in a mouse model of infection.


ensembl_gene_id: Q59RR3
symbol: MNL1
gene_biotype: protein_coding
description:
  Transcriptional regulator MNL1; Transcription factor that activates stress response genes via SLE (STRE-like) elements. Required for adaptation to weak acid stress such as acetic acid stress, but seems not involved in the response to heat, osmotic, ethanol, nutrient, oxidative, or heavy-metal stress. Activates a subset of the genes that are repressed by NRG1.


ensembl_gene_id: Q59RW5
symbol: HXK1
gene_biotype: protein_coding
description:
  N-acetylglucosamine kinase 1; Component of the N-acetylglucosamine catabolic cascade that phosphorylates N-acetylglucosamine (GlcNAc), and allows the unique ability to utilise GlcNAc as carbon source. Converts GlcNAc to GlcNAc- 6-P. Also able to phosphorylate glucose, glucosamine (GlcN), and mannose. Galactose, fructose, N-acetylmannosamine (ManNAc), mannosamine (ManN), galactosamine (GalN), and N-acetylgalactosamine (GalNAc) are not phosphorylated by HXK1. GlcNAc metabolism is closely associated with virulence and morphogenesis, and is involved in the cell wall synthesis. Acts both as [...]


ensembl_gene_id: Q59S06
symbol: NOP58
gene_biotype: protein_coding
description:
  Nucleolar protein 58; Required for pre-18S rRNA processing. May bind microtubules (By similarity); Belongs to the NOP5/NOP56 family.


ensembl_gene_id: Q59S27
symbol: RTT106
gene_biotype: protein_coding
description:
  Histone chaperone RTT106; Histones H3 and H4 chaperone involved in the nucleosome formation and heterochromatin silencing. Required for the deposition of H3K56ac-carrying H3-H4 complex onto newly-replicated DNA. Plays a role in the transcriptional regulation of the cell-cycle dependent histone genes by creating a repressive structure at the core histone gene promoter (By similarity).


ensembl_gene_id: Q59S42
symbol: PSF1
gene_biotype: protein_coding
description:
  DNA replication complex GINS protein PSF1; The GINS complex plays an essential role in the initiation of DNA replication.


ensembl_gene_id: Q59S43
symbol: MED11
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 11; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).


ensembl_gene_id: Q59S45
symbol: CaO19.6907
gene_biotype: protein_coding
description:
  DNA damage-binding protein CMR1; DNA-binding protein that binds to both single- and double- stranded DNA. Binds preferentially to UV-damaged DNA. May be involved in DNA-metabolic processes.


ensembl_gene_id: Q59S50
symbol: DBP7
gene_biotype: protein_coding
description:
  ATP-dependent RNA helicase DBP7; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.


ensembl_gene_id: Q59S52
symbol: MDM12
gene_biotype: protein_coding
description:
  Mitochondrial distribution and morphology protein 12; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM12 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pat [...]


ensembl_gene_id: Q59S59
symbol: MRH4
gene_biotype: protein_coding
description:
  ATP-dependent RNA helicase MRH4, mitochondrial; ATP-binding RNA helicase involved in mitochondrial RNA metabolism. Required for maintenance of mitochondrial DNA (By similarity); Belongs to the DEAD box helicase family. MRH4 subfamily.


ensembl_gene_id: Q59S63
symbol: PUS1
gene_biotype: protein_coding
description:
  tRNA pseudouridine synthase 1; Formation of pseudouridine at positions 27 and 28 in the anticodon stem and loop of transfer RNAs; at positions 34 and 36 of intron-containing precursor tRNA(Ile) and at position 35 in the intron- containing tRNA(Tyr). Catalyzes pseudouridylation at position 44 in U2 snRNA. Also catalyzes pseudouridylation of mRNAs. Belongs to the tRNA pseudouridine synthase TruA family.


ensembl_gene_id: Q59S66
symbol: IPL1
gene_biotype: protein_coding
description:
  Spindle assembly checkpoint kinase; Required for high-fidelity chromosome segregation during the later part of each cell cycle. Acts in opposition to the phosphatase PP1. Has a role in attaching the kinetochores to the microtubules and ensuring that sister kinetochores connect to opposite poles. The promotion of bi-orientation is achieved by selectively detaching kinetochore-microtubule attachments that are not under tension. Phosphorylates histone H3 to form H3S10ph during mitosis and meiosis (By similarity); Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Au [...]


ensembl_gene_id: Q59S72
symbol: ALG11
gene_biotype: protein_coding
description:
  GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase; Required for N-linked oligosaccharide assembly. Has a role in the last step of the synthesis of the Man(5)GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum (By similarity); Belongs to the glycosyltransferase group 1 family.


ensembl_gene_id: Q59S78
symbol: SAR1
gene_biotype: protein_coding
description:
  Small COPII coat GTPase SAR1; Small GTPase component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. SAR1 controls the coat assembly in a stepwise manner. Activated SAR1-GTP binds to membranes first and recruits the SEC23/24 complex. These SEC23/24-SAR1 prebudding intermediates are then collected by the SEC13/31 complex as subunits polymerize to form coated trans [...]


ensembl_gene_id: Q59S85
symbol: LPE10
gene_biotype: protein_coding
description:
  Mitochondrial inner membrane magnesium transporter LPE10; Mitochondrial inner membrane magnesium transporter required for mitochondrial magnesium homeostasis. Modulates the conductance of the MRS2 channel. Involved in the splicing of mRNA group II introns in mitochondria by affecting mitochondrial magnesium concentrations, which are critical for group II intron splicing.


ensembl_gene_id: Q59SD1
symbol: VPS28
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 28; Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.


ensembl_gene_id: Q59SF7
symbol: PIR1
gene_biotype: protein_coding
description:
  Cell wall mannoprotein PIR1; Component of the outer cell wall layer required for stability of the cell wall and specifically for cell wall rigidity.


ensembl_gene_id: Q59SG9
symbol: PGA55
gene_biotype: protein_coding
description:
  Probable GPI-anchored adhesin-like protein PGA55; Predicted GPI-ancored adhesin-like protein which may be involved in filamentous growth and chlamydospore formation.


ensembl_gene_id: Q59SI2
symbol: PAM18
gene_biotype: protein_coding
description:
  Mitochondrial import inner membrane translocase subunit TIM14; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, it is required to stimulate activity of mtHSP70 (SSC1) (By similarity); Belongs to the TIM14 family.


ensembl_gene_id: Q59SI5
symbol: MMM1
gene_biotype: protein_coding
description:
  Maintenance of mitochondrial morphology protein 1; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta- barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 su [...]


ensembl_gene_id: Q59SJ9
symbol: DPH2
gene_biotype: protein_coding
description:
  Diphthamide biosynthesis protein 2-1; Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.


ensembl_gene_id: Q59SN0
symbol: RRP36
gene_biotype: protein_coding
description:
  rRNA biogenesis protein RRP36; Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway (By similarity).


ensembl_gene_id: Q59SN6
symbol: CRZ2
gene_biotype: protein_coding
description:
  Transcriptional regulator CRZ2; Transcription factor that regulates pH-induced filamentation with RIM101. Required for yeast cell adherence to silicone substrate and biofilm formation.


ensembl_gene_id: Q59SR4
symbol: HBR3
gene_biotype: protein_coding
description:
  20S-pre-rRNA D-site endonuclease NOB1; Required for the synthesis of 40S ribosome subunits. Has a role in processing 20S pre-rRNA into the mature 18S rRNA, where it is required for cleavage at the 3' end of the mature 18S rRNA (D-site). Accompanies the 20S pre-rRNA from the nucleus to the cytoplasm. Belongs to the NOB1 family.


ensembl_gene_id: Q59SR6
symbol: IRS4
gene_biotype: protein_coding
description:
  Increased rDNA silencing protein 4; Positive regulator of phosphatidylinositol 4,5-bisphosphate turnover and negatively regulates signaling through the cell integrity pathway. Involved in rDNA silencing (By similarity).


ensembl_gene_id: Q59ST1
symbol: MEU1
gene_biotype: protein_coding
description:
  S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.


ensembl_gene_id: Q59ST6
symbol: RRD2
gene_biotype: protein_coding
description:
  Serine/threonine-protein phosphatase 2A activator 2; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A- phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex (By similarity).


ensembl_gene_id: Q59ST8
symbol: CLP1
gene_biotype: protein_coding
description:
  mRNA cleavage and polyadenylation factor CLP1; Required for endonucleolytic cleavage during polyadenylation- dependent pre-mRNA 3'-end formation.


ensembl_gene_id: Q59SU1
symbol: SAP9
gene_biotype: protein_coding
description:
  Candidapepsin-9; Secreted aspartic peptidases (SAPs) are a group of ten acidic hydrolases considered as key virulence factors. These enzymes supply the fungus with nutrient amino acids as well as are able to degrade the selected host's proteins involved in the immune defense. Involved in triggering host polymorphonuclear neutrophils chemotaxis toward germ tubes. Moreover, acts toward human hemoglobin though limited proteolysis to generate a variety of antimicrobial hemocidins, enabling to compete with the other microorganisms of the same physiological niche using the microbicidal pepti [...]


ensembl_gene_id: Q59SU5
symbol: HTA1
gene_biotype: protein_coding
description:
  Histone H2A.1; Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.


ensembl_gene_id: Q59T36
symbol: YTH1
gene_biotype: protein_coding
description:
  mRNA 3'-end-processing protein YTH1; Component of the cleavage factor I (CF I) involved in pre- mRNA 3'-end processing; Belongs to the CPSF4/YTH1 family.


ensembl_gene_id: Q59T38
symbol: CaO19.6879
gene_biotype: protein_coding
description:
  tRNA-splicing endonuclease subunit Sen34; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structura [...]


ensembl_gene_id: Q59TB2
symbol: SUV3
gene_biotype: protein_coding
description:
  ATP-dependent RNA helicase SUV3, mitochondrial; Required for intron-independent turnover and processing of mitochondrial RNA. It is a key control element in nuclear-mitochondrial interactions (By similarity). Required for embedded hyphal growth, for wild-type respiratory growth, and biofilm development. Required for chlamydospore formation, distinctive morphological feature of the fungal pathogen C.albicans that can be induced to form in oxygen- limited environments and has been reported in clinical specimens. Plays am important role in virulence.


ensembl_gene_id: Q59TD3
symbol: MED8
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 8; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).


ensembl_gene_id: Q59TD5
symbol: NDH51
gene_biotype: protein_coding
description:
  NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain.


ensembl_gene_id: Q59TN1
symbol: TRM5
gene_biotype: protein_coding
description:
  tRNA (guanine(37)-N1)-methyltransferase; Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding; Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.


ensembl_gene_id: Q59TN9
symbol: ATG20
gene_biotype: protein_coding
description:
  Autophagy-related protein 20; Required for cytoplasm to vacuole transport (Cvt), pexophagy and mitophagy. Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. Functions in protein retrieval from the endocytic pathway (By similarity).


ensembl_gene_id: Q59TP1
symbol: RBT1
gene_biotype: protein_coding
description:
  Cell wall protein RTB1; GPI-anchored cell wall protein required for mating efficiency, biofilm formation, and virulence. Involved in normal disseminated infection, but not in intestinal colonization.


ensembl_gene_id: Q59TU0
symbol: EGD1
gene_biotype: protein_coding
description:
  Nascent polypeptide-associated complex subunit beta; Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting. The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the [...]


ensembl_gene_id: Q59U10
symbol: BCR1
gene_biotype: protein_coding
description:
  Biofilm and cell wall regulator 1; Transcription factor which acts as a master regulator of biofilm formation. Biofilms play an important role in pathogenesis and produce many infections such as oropharyngeal candidiasis or vulvovaginal candidiasis. Controls the expression of genes that govern cell-surface properties such as ALS1, ALS3, HWP1 AND HYR1. Down-stream component of the hyphal regulatory network that couples expression of cell-surface genes to hyphal differentiation.


ensembl_gene_id: Q59U11
symbol: GRC3
gene_biotype: protein_coding
description:
  Polynucleotide 5'-hydroxyl-kinase GRC3; Polynucleotide 5'-kinase involved in rRNA processing. Belongs to the Clp1 family. NOL9/GRC3 subfamily.


ensembl_gene_id: Q59U67
symbol: TAF4
gene_biotype: protein_coding
description:
  Transcription initiation factor TFIID subunit 4; Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of tra [...]


ensembl_gene_id: Q59U73
symbol: MED4
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 4; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).


ensembl_gene_id: Q59U81
symbol: SWR1
gene_biotype: protein_coding
description:
  Helicase SWR1; Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling; Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.


ensembl_gene_id: Q59U85
symbol: VMA10
gene_biotype: protein_coding
description:
  V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.


ensembl_gene_id: Q59UG3
symbol: ATG4
gene_biotype: protein_coding
description:
  Cysteine protease ATG4; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Cleaves the C-terminal amino acid of ATG8 to reveal a C-terminal glycine. ATG8 ubiquitin-like activity requires the exposure of the glycine at the C- terminus for its conjugation to phospha [...]


ensembl_gene_id: Q59UH5
symbol: SLD2
gene_biotype: protein_coding
description:
  DNA replication regulator SLD2; Has a role in the initiation of DNA replication. Required at S-phase checkpoint (By similarity); Belongs to the SLD2 family.


ensembl_gene_id: Q59UH7
symbol: ATP25
gene_biotype: protein_coding
description:
  ATPase synthesis protein 25, mitochondrial; Probable mitochondrial mRNA stabilization factor. Belongs to the ATP25 family.


ensembl_gene_id: Q59UH8
symbol: CaO19.2386
gene_biotype: protein_coding
description:
  U3 small nucleolar RNA-associated protein 11; Involved in nucleolar processing of pre-18S ribosomal RNA.


ensembl_gene_id: Q59UP6
symbol: PGA10
gene_biotype: protein_coding
description:
  GPI-anchored protein 10; Heme-binding protein involved in heme-iron utilization. The ability to acquire iron from host tissues is a major virulence factor of pathogenic microorganisms. Involved in biofilm formation. Belongs to the RBT5 family.


ensembl_gene_id: Q59UQ7
symbol: RCH1
gene_biotype: protein_coding
description:
  Solute carrier RCH1; Solute carrier protein that negatively regulates the cytosolic homeostasis in response to high levels of extracellular calcium.


ensembl_gene_id: Q59UT4
symbol: RBT5
gene_biotype: protein_coding
description:
  Repressed by TUP1 protein 5; GPI-linked hyphal surface heme-binding protein involved in heme-iron utilization. Heme transfer can occur bi-directionally between PGA7 and RBT5, supporting a model in which they cooperate in a heme- acquisition system. The ability to acquire iron from host tissues is a major virulence factor of pathogenic microorganisms. Required for biofilm formation.


ensembl_gene_id: Q59UT5
symbol: PGA7
gene_biotype: protein_coding
description:
  Predicted GPI-anchored protein 7; GPI-linked hyphal surface heme-binding protein involved in heme-iron utilization. Heme transfer can occur bi-directionally between PGA7 and RBT5, supporting a model in which they cooperate in a heme- acquisition system. The ability to acquire iron from host tissues is a major virulence factor of pathogenic microorganisms. Required for biofilm formation.


ensembl_gene_id: Q59UY7
symbol: SEF1
gene_biotype: protein_coding
description:
  Transcriptional regulatory protein SEF1; Transcription factor which plays an essential role in virulence by activating the transcription of iron uptake genes such as FRE7 in iron-poor environments such as the host bloodstream and internal organs. Promotes commensalism in a mouse model of gastrointestinal infection.


ensembl_gene_id: Q59UY8
symbol: RAD51
gene_biotype: protein_coding
description:
  DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.


ensembl_gene_id: Q59V01
symbol: PGA23
gene_biotype: protein_coding
description:
  Predicted GPI-anchored protein 23; Probable cell surface protein involved in the process of adhesion and early events of invasion.


ensembl_gene_id: Q59V02
symbol: PGA22
gene_biotype: protein_coding
description:
  Probable GPI-anchored adhesin-like protein PGA22; Putative adhesin which may be involved in cell adhesion and virulence.


ensembl_gene_id: Q59V88
symbol: RFX1
gene_biotype: protein_coding
description:
  Transcriptional regulator RFX1; Transcription factor involved in DNA damage responses, morphogenesis, and virulence.


ensembl_gene_id: Q59V93
symbol: CaO19.3859
gene_biotype: protein_coding
description:
  Very-long-chain 3-oxoacyl-CoA reductase; Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3- ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids. Belongs to the short-chain dehydrogenases/reductases (SDR) family.


ensembl_gene_id: Q59VC6
symbol: DAD3
gene_biotype: protein_coding
description:
  DASH complex subunit DAD2; Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity).


ensembl_gene_id: Q59VF4
symbol: HAT1
gene_biotype: protein_coding
description:
  Histone acetyltransferase type B catalytic subunit; Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-14' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair; Belongs to the HAT1 family.


ensembl_gene_id: Q59VH7
symbol: SAP7
gene_biotype: protein_coding
description:
  Candidapepsin-7; Secreted aspartic peptidases (SAPs) are a group of ten acidic hydrolases considered as key virulence factors. These enzymes supply the fungus with nutrient amino acids as well as are able to degrade the selected host's proteins involved in the immune defense.


ensembl_gene_id: Q59VL7
symbol: MNN15
gene_biotype: protein_coding
description:
  Putative alpha-1,3-mannosyltransferase MNN15; Responsible for addition of the terminal mannose residues to the outer chain of core N-linked polysaccharides and to O-linked mannotriose. Implicated in late Golgi modifications (By similarity). Belongs to the MNN1/MNT family.


ensembl_gene_id: Q59VM4
symbol: RPN4
gene_biotype: protein_coding
description:
  Transcriptional regulator RPN4; Transcriptional activator of a number of genes encoding proteasomal subunits. Binds to the DNA sequence 5'-GAAGGCAAAA-3', enriched in regions upstream of proteasome genes.


ensembl_gene_id: Q59VM7
symbol: GIG1
gene_biotype: protein_coding
description:
  N-acetylglucosamine-induced protein 1; N-acetylglucosamine-induced protein which plays a role in the N-acetylglucosamine metabolic pathway.


ensembl_gene_id: Q59VN0
symbol: GPI18
gene_biotype: protein_coding
description:
  GPI mannosyltransferase 2; Mannosyltransferase involved in glycosylphosphatidylinositol- anchor biosynthesis. Transfers the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly (By similarity).


ensembl_gene_id: Q59VN2
symbol: HHT21
gene_biotype: protein_coding
description:
  Histone H3.1/H3.2; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).


ensembl_gene_id: Q59VN4
symbol: HHF1
gene_biotype: protein_coding
description:
  Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.


ensembl_gene_id: Q59VP0
symbol: BST1
gene_biotype: protein_coding
description:
  GPI inositol-deacylase; Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.


ensembl_gene_id: Q59VP1
symbol: HTB2
gene_biotype: protein_coding
description:
  Histone H2B.2; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.


ensembl_gene_id: Q59VP2
symbol: HTA2
gene_biotype: protein_coding
description:
  Histone H2A.2; Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.


ensembl_gene_id: Q59VP7
symbol: ERB1
gene_biotype: protein_coding
description:
  Ribosome biogenesis protein ERB1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.


ensembl_gene_id: Q59VQ3
symbol: MAD2
gene_biotype: protein_coding
description:
  Spindle assembly checkpoint component MAD2; Central component of the spindle assembly checkpoint which is a feedback control that prevents cells with incompletely assembled spindles from leaving mitosis. Plays a key role in virulence, probably through cell cycle checkpoint functions, especially those monitoring the integrity of DNA and chromosome segregation, which might be required for the pathogen to repair damage caused by host defense. Belongs to the MAD2 family.


ensembl_gene_id: Q59VQ8
symbol: WAR1
gene_biotype: protein_coding
description:
  Transcriptional regulator WAR1; Transcription factor required for yeast cell adherence to silicone substrate. Plays a role in resistance to weak organic acids such as acetate and sorbate. Binds in vitro to a nitric oxide- responsive element (NORE) but seems not to be involved in response to nitrosative stress.


ensembl_gene_id: Q59VR1
symbol: SKO1
gene_biotype: protein_coding
description:
  Transcriptional regulator SKO1; Transcription repressor involved in cell wall damage response. Regulates 79 caspofungin-responsive genes, including several cell wall biogenesis genes such as CRH11, MNN2, and SKN1. Controls also the expression of pathogenesis and hyphal related genes and represses the yeast-to-hypha transition. Mediates the response to oxidative stress.


ensembl_gene_id: Q59VR3
symbol: FPR3
gene_biotype: protein_coding
description:
  FK506-binding protein 3; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity); Belongs to the FKBP-type PPIase family. FKBP3/4 subfamily.


ensembl_gene_id: Q59VW6
symbol: PGA5
gene_biotype: protein_coding
description:
  1,3-beta-glucanosyltransferase PGA5; Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. Involved in spore wall assembly (By similarity).


ensembl_gene_id: Q59VW7
symbol: TIM21
gene_biotype: protein_coding
description:
  Mitochondrial import inner membrane translocase subunit TIM21; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to keep the TOM and the TIM23 complexes in close contact. At some point, it is released from the TOM23 complex to allow protein translocation into the mitochondrial matrix (By similarity).


ensembl_gene_id: Q59VX8
symbol: SEP7
gene_biotype: protein_coding
description:
  Septation protein 7; Septins are GTPases involved in cytokinesis that assemble early in the cell cycle as a patch at the incipient bud site and form a ring before bud emergence, which transforms into an hour-glass shaped collar of cortical filaments that spans both sides of the mother-bud neck. This collar persists until just before cytokinesis, when it splits into two rings that occupy opposite sides of the neck. The septins at the bud neck serve as a structural scaffold that recruits different components involved in diverse processes at specific stages during the cell cycle. Many pro [...]


ensembl_gene_id: Q59VX9
symbol: CaO19.3679
gene_biotype: protein_coding
description:
  NAD(P)H-hydrate epimerase; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.


ensembl_gene_id: Q59VY1
symbol: ATG5
gene_biotype: protein_coding
description:
  Autophagy protein 5; Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy). Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1- like activating enzyme and ATG10 as an E2- [...]


ensembl_gene_id: Q59W04
symbol: GON7
gene_biotype: protein_coding
description:
  EKC/KEOPS complex subunit GON7; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. GON7 likely plays a supporting role to the catalytic subunit KAE1 in the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptiona [...]


ensembl_gene_id: Q59W44
symbol: TIM50
gene_biotype: protein_coding
description:
  Mitochondrial import inner membrane translocase subunit TIM50; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to direct preproteins in transit and direct them to the channel protein TIM23, and possibly facilitates transfer of the translocating proteins from the TOM complex to the TIM23 complex (By similarity).


ensembl_gene_id: Q59W50
symbol: CWC2
gene_biotype: protein_coding
description:
  Pre-mRNA-splicing factor CWC2; Involved in the first step of pre-mRNA splicing. Required for cell growth and cell cycle control. Plays a role in the levels of the U1, U4, U5 and U6 snRNAs and the maintenance of the U4/U6 snRNA complex. May provide the link between the 'nineteen complex' NTC spliceosome protein complex and the spliceosome through the U6 snRNA. Associates predominantly with U6 snRNAs in assembled active spliceosomes. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic [...]


ensembl_gene_id: Q59W52
symbol: PRP28
gene_biotype: protein_coding
description:
  Pre-mRNA-splicing ATP-dependent RNA helicase PRP28; ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity).


ensembl_gene_id: Q59W55
symbol: PRM1
gene_biotype: protein_coding
description:
  Plasma membrane fusion protein PRM1; Involved in cell fusion during mating by stabilizing the plasma membrane fusion event.


ensembl_gene_id: Q59W62
symbol: GIN4
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase GIN4; Serine/threonine-protein kinase which regulates the localization and the function of the septins during mitosis. Involved in the formation of the septin ring but not the basal septin band. Phosphorylates septins CDC11 and SEP7. Required for the transition from pseudohyphae to hyphae. Acts upstream of IRS4 and INP51 in regulating cell wall integrity responses. Involved in propolis-induced cell death.


ensembl_gene_id: Q59W63
symbol: KRR1
gene_biotype: protein_coding
description:
  KRR1 small subunit processome component; Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.


ensembl_gene_id: Q59WB3
symbol: GAP4
gene_biotype: protein_coding
description:
  S-adenosylmethionine permease GAP4; Amino-acid permease involved in S-adenosylmethionine (SAM) transport and required for SAM-induced morphogenesis. GAP4 is also able to transport arginine and thialysine, and thus probably also lysine.


ensembl_gene_id: Q59WB9
symbol: ZCF23
gene_biotype: protein_coding
description:
  Glucose starvation modulator protein 1; Transcription factor which regulates nonfermentable carbon utilization; Belongs to the ERT1/acuK family.


ensembl_gene_id: Q59WC6
symbol: YPD1
gene_biotype: protein_coding
description:
  Phosphorelay intermediate protein YPD1; Phosphorelay intermediate protein that is part of the bifurcated SLN1-YPD1-SKN7/SSK1 two-component regulatory system, which controls activity of the HOG1 pathway and gene expression in response to oxidative stress and probably to changes in the osmolarity of the extracellular environment. Catalyzes the phosphoryl group transfer from the membrane-bound histidine kinase SLN1 to two distinct response regulators SSK1 and SKN7.


ensembl_gene_id: Q59WD3
symbol: GPX3
gene_biotype: protein_coding
description:
  Glutathione peroxidase-like peroxiredoxin GPX3; Involved in oxidative stress response and redox homeostasis. Functions as a sensor and transducer of hydroperoxide stress. In response to hydroperoxide stress it oxidizes (activates) the transcription activator CAP1, which is involved in transcription activation of genes of the oxidative stress response pathway. May also play a direct role in hydroperoxide scavenging. The enzyme is not required for the glutaredoxin-mediated antioxidant function. In the presence of peroxides, GPX3 is directly oxidized at Cys-43 to form a cysteine sulfenic  [...]


ensembl_gene_id: Q59WD5
symbol: STU1
gene_biotype: protein_coding
description:
  Protein STU1; Microtubule binding protein that promotes the stabilization of dynamic microtubules. Required for mitotic spindle formation (By similarity).


ensembl_gene_id: Q59WF4
symbol: MNN2
gene_biotype: protein_coding
description:
  Alpha-1,2-mannosyltransferase MNN2; Alpha-1,2-mannosyltransferase required for cell wall integrity. Responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides. Addition of alpha-1,2-mannose is required for stabilization of the alpha-1,6-mannose backbone and hence regulates mannan fibril length; and is important for both immune recognition and virulence. Promotes iron uptake and usage along the endocytosis pathway under iron-limiting conditions; Belongs to the MNN1/MNT family.


ensembl_gene_id: Q59WG5
symbol: CaO19.2336
gene_biotype: protein_coding
description:
  Probable pathogenesis-related protein CaO19.2336; Secreted protein that acts as a virulence factor during infections.


ensembl_gene_id: Q59WG7
symbol: BIG1
gene_biotype: protein_coding
description:
  Protein BIG1; Required for normal beta-1,6-glucan synthesis, for hyphal morphogenesis, adhesion and virulence; Belongs to the BIG1 family.


ensembl_gene_id: Q59WH0
symbol: ADA2
gene_biotype: protein_coding
description:
  Transcriptional adapter 2; Functions as component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and ADA. SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). SALSA, an altered form of SAGA, may be involved in positive transcriptional regulati [...]


ensembl_gene_id: Q59WH7
symbol: UBA4
gene_biotype: protein_coding
description:
  Adenylyltransferase and sulfurtransferase UBA4; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Acts by mediating the C-terminal thiocarboxylation of sulfur carrier URM1. Its N-terminus first activates URM1 as acyl-adenylate (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 to form thiocarboxylation (-COSH) of its C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1. Subseque [...]


ensembl_gene_id: Q59WI0
symbol: CaO19.2320
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase RIO1; Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.


ensembl_gene_id: Q59WI7
symbol: CGR1-2
gene_biotype: protein_coding
description:
  rRNA-processing protein CGR1; Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit; Belongs to the CGR1 family.


ensembl_gene_id: Q59WJ4
symbol: PFS2
gene_biotype: protein_coding
description:
  Polyadenylation factor subunit 2; Required for 3'-end cleavage and polyadenylation of pre- mRNAs. Also involved in chromosome segregation where it has a role in chromosome attachment to the mitotic spindle (By similarity).


ensembl_gene_id: Q59WJ5
symbol: ADI1
gene_biotype: protein_coding
description:
  1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).


ensembl_gene_id: Q59WK2
symbol: URM1
gene_biotype: protein_coding
description:
  Ubiquitin-related modifier 1; Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target pr [...]


ensembl_gene_id: Q59WT0
symbol: ARC18
gene_biotype: protein_coding
description:
  Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.


ensembl_gene_id: Q59WU8
symbol: KAR5
gene_biotype: protein_coding
description:
  Nuclear fusion protein KAR5; Required for nuclear membrane fusion during karyogamy. Belongs to the KAR5 family.


ensembl_gene_id: Q59WV0
symbol: RIM9
gene_biotype: protein_coding
description:
  pH-response regulator protein palI/RIM9; Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH; Belongs to the palI/RIM9 family.


ensembl_gene_id: Q59X11
symbol: SPO72
gene_biotype: protein_coding
description:
  Autophagy-related protein 2; Required for cytoplasm to vacuole transport (Cvt) vesicles and autophagosomes completion and peroxisome degradation. Belongs to the ATG2 family.


ensembl_gene_id: Q59X23
symbol: PMT4
gene_biotype: protein_coding
description:
  Dolichyl-phosphate-mannose--protein mannosyltransferase 4; Protein mannosyltransferase (PMT) involved in hyphal growth and drug sensitivity. Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. PMT1, PMT2 and PMT4 account for most of the protein-O-glycosylation activity, while PMT5 and PMT6 may specifically modulate a much narrower spectrum of target proteins. Accounts for the O-glycosylation of AXL2, responsible for bud site selection, as well as of the SEC20 t-SNARE component. O-glycosylation of SEC20 is essential for its stability. Required for biofilm formation. [...]


ensembl_gene_id: Q59X26
symbol: CSM3
gene_biotype: protein_coding
description:
  Chromosome segregation in meiosis protein 3; Forms a fork protection complex (FPC) with TOF1 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors (By similarity).


ensembl_gene_id: Q59X38
symbol: NOP7
gene_biotype: protein_coding
description:
  Pescadillo homolog; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome (By similarity). Required for the transition from hyphal to yeast growth; Belongs to the pescadillo family.


ensembl_gene_id: Q59X39
symbol: GTF1
gene_biotype: protein_coding
description:
  Glutamyl-tRNA(Gln) amidotransferase subunit F, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Required for proper protein synthesis within the mitochondrion; Belongs to the GatF family.


ensembl_gene_id: Q59X40
symbol: SRB5
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 18; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).


ensembl_gene_id: Q59X49
symbol: DDR48
gene_biotype: protein_coding
description:
  Stress protein DDR48; Cell surface protein involved in the ability to sense and respond to changes in the host environment. Required for stress response and confers partial antifungal drug resistance. Contributes to the DNA damage response. Required for the flocculation response stimulated by 3-aminotriazole-induced amino acid starvation. Belongs to the DDR48 family.


ensembl_gene_id: Q59X67
symbol: EFG1
gene_biotype: protein_coding
description:
  Enhanced filamentous growth protein 1; Transcriptional regulator of the switch between 2 heritable states, the white and opaque states. These 2 cell types differ in many characteristics, including cell structure, mating competence, and virulence. Each state is heritable for many generations, and switching between states occurs stochastically, at low frequency. Antagonizes the action of WOR1, WOR2 and CZF1, and promotes the white state. In white cells, EFG1 represses WOR1 indirectly through WOR2 to maintain white cell identity. Binds target gene promoters at the EFG1 recognition sequenc [...]


ensembl_gene_id: Q59X94
symbol: CCP2
gene_biotype: protein_coding
description:
  Putative heme-binding peroxidase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the peroxidase family. Cytochrome c peroxidase subfamily.


ensembl_gene_id: Q59XA7
symbol: HYR3
gene_biotype: protein_coding
description:
  Hyphally regulated cell wall protein 3; GPI-anchored cell wall protein involved in cell wall organization, hyphal growth, as well as in host-fungal interaction and virulence; Belongs to the HYR1/IFF family.


ensembl_gene_id: Q59XB0
symbol: IFF8
gene_biotype: protein_coding
description:
  Cell wall protein IFF7; GPI-anchored cell wall protein involved in cell wall organization, hyphal growth, as well as in host-fungal interaction and virulence; Belongs to the HYR1/IFF family.


ensembl_gene_id: Q59XL0
symbol: IFF6
gene_biotype: protein_coding
description:
  Cell wall protein IFF6; GPI-anchored cell wall protein involved in cell wall organization, hyphal growth, as well as in host-fungal interaction and virulence; Belongs to the HYR1/IFF family.


ensembl_gene_id: Q59XM0
symbol: QDR3
gene_biotype: protein_coding
description:
  MFS antiporter QDR3; MFS antiporter that does not display functional linkage as drug transporter and performs functions that significantly affect biofilm development and virulence. No substrate for transport has been identified yet, but plays an important role in the growth in the host. Belongs to the major facilitator superfamily. CAR1 family.


ensembl_gene_id: Q59XM1
symbol: EXO84
gene_biotype: protein_coding
description:
  Exocyst complex component EXO84; Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Plays a role in both the assembly of the exocyst and the polarization of this complex to specific sites of the plasma membrane for exocytosis. Also involved in assembly of the spliceosome (By similarity).


ensembl_gene_id: Q59XP0
symbol: SEC9
gene_biotype: protein_coding
description:
  Protein transport protein SEC9; Late secretory t-SNARE protein required for secretion and proper cytokinesis. Plays an important role in the secretion of virulence-associated extracellular enzymes and vesicle-mediated polarized hyphal growth.


ensembl_gene_id: Q59XQ1
symbol: HAL22
gene_biotype: protein_coding
description:
  3'(2'),5'-bisphosphate nucleotidase 2; Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. Regulates the flux of sulfur in the sulfur- activation pathway by converting PAPS to APS. Involved in salt tolerance (By similarity).


ensembl_gene_id: Q59XU5
symbol: RAS1
gene_biotype: protein_coding
description:
  Ras-like protein 1; Required for the regulation of both a MAP kinase signaling pathway and a cAMP signaling pathway. The activation of these pathways contributes to the pathogenicity of the cells through the induction of the morphological transition from the yeast to the polarized filamentous form (By similarity).


ensembl_gene_id: Q59XV0
symbol: SET2
gene_biotype: protein_coding
description:
  Histone-lysine N-methyltransferase, H3 lysine-36 specific; Histone methyltransferase that trimethylates histone H3 'Lys- 36' forming H3K36me3. Involved in transcription elongation as well as in transcription repression; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.


ensembl_gene_id: Q59XW9
symbol: IRC22-2
gene_biotype: protein_coding
description:
  Increased recombination centers protein 22-2; Is probably involved in a pathway contributing to genomic integrity; Belongs to the IRC22 family.


ensembl_gene_id: Q59XX2
symbol: MP65
gene_biotype: protein_coding
description:
  Cell surface mannoprotein MP65; Surface mannoprotein required for hyphal morphogenesis, surface adherence, and pathogenicity. Contributes in a high proportion to the carbohydrate component of the matrix due to high levels of glycosylation and may play important roles during biofilm development and maintenance. Acts as a major antigen target of host cell-mediated immune response. Induces extensive T-cell proliferation of human peripheral blood mononuclear cells. Facilitates host dendritic cells maturation and promotes cytokine production through its glycosylated portion while its protei [...]


ensembl_gene_id: Q59XY9
symbol: OCA1
gene_biotype: protein_coding
description:
  Putative tyrosine-protein phosphatase OCA1; Putative tyrosine-protein phosphatase required for protection against superoxide stress.


ensembl_gene_id: Q59Y20
symbol: DSE1
gene_biotype: protein_coding
description:
  Protein DSE1; Involved in cell wall metabolism and required for the separation of the mother and daughter cells.


ensembl_gene_id: Q59Y31
symbol: YWP1
gene_biotype: protein_coding
description:
  Yeast-form wall Protein 1; Cell wall protein which plays an anti-adhesive role and promotes dispersal of yeast forms, which allows the organism to seek new sites for colonization.


ensembl_gene_id: Q59Y41
symbol: MSH3
gene_biotype: protein_coding
description:
  DNA mismatch repair protein MSH3; Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate- binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch bindi [...]


ensembl_gene_id: Q59Y46
symbol: MFG1
gene_biotype: protein_coding
description:
  Morphogenetic regulator of filamentous growth protein 1; Transcriptional regulator with a general role in all morphogenetically distinct forms of filamentous growth, namely invasive growth and biofilm formation. May control FLO11 gene expression as part of a promoter-bound complex with FLO8 and MSS1. Important for virulence; Belongs to the MFG1 family.


ensembl_gene_id: Q59YD9
symbol: CFD1
gene_biotype: protein_coding
description:
  Cytosolic Fe-S cluster assembly factor CFD1; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Required for biogenesis and export of both ribosomal subunits, which may reflect a role in assembly of the Fe/S clusters in RLI1, a protein which performs rRNA processing and ribosome export; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD [...]


ensembl_gene_id: Q59YF0
symbol: SSO2
gene_biotype: protein_coding
description:
  Protein transport protein SSO2; Late secretory t-SNARE protein required for secretion and proper cytokinesis. Plays an important role in the secretion of virulence-associated extracellular enzymes and vesicle-mediated polarized hyphal growth.


ensembl_gene_id: Q59YF4
symbol: IRC22-1
gene_biotype: protein_coding
description:
  Increased recombination centers protein 22-1; Is probably involved in a pathway contributing to genomic integrity; Belongs to the IRC22 family.


ensembl_gene_id: Q59YG5
symbol: TIM23
gene_biotype: protein_coding
description:
  Mitochondrial import inner membrane translocase subunit TIM23; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.


ensembl_gene_id: Q59YH3
symbol: CCN1
gene_biotype: protein_coding
description:
  G1/S-specific cyclin CCN1; G1/S-specific cyclin essential for the control of the cell cycle at the G1/S (start) transition and for maintenance of filamentous growth. Through binding to CDC28 controls the phosphorylation of CDC11 and SEC2 upon induction of filamentous growth.


ensembl_gene_id: Q59YH4
symbol: CCT7
gene_biotype: protein_coding
description:
  T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.


ensembl_gene_id: Q59YK4
symbol: RIM21
gene_biotype: protein_coding
description:
  pH-response regulator protein palH/RIM21; Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH; Belongs to the palH/RIM21 family.


ensembl_gene_id: Q59YL9
symbol: ESF2
gene_biotype: protein_coding
description:
  Pre-rRNA-processing protein ESF2; Involved in the small subunit (SSU) processome assembly and function, and in the 18S rRNA synthesis. Required for the early cleavages at sites A0, A1 and A2 (By similarity); Belongs to the ESF2/ABP1 family.


ensembl_gene_id: Q59YS7
symbol: MNN14
gene_biotype: protein_coding
description:
  Putative alpha-1,3-mannosyltransferase MNN14; Responsible for addition of the terminal mannose residues to the outer chain of core N-linked polysaccharides and to O-linked mannotriose. Implicated in late Golgi modifications (By similarity). Involved in virulence.


ensembl_gene_id: Q59YT1
symbol: QDR2
gene_biotype: protein_coding
description:
  MFS antiporter QDR2; MFS antiporter that does not display functional linkage as drug transporter and performs functions that significantly affect biofilm development and virulence. No substrate for transport has been identified yet, but plays an important role in the growth in the host.


ensembl_gene_id: Q59YV0
symbol: CaO19.6973
gene_biotype: protein_coding
description:
  Lon protease homolog 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import.


ensembl_gene_id: Q59YV2
symbol: DIE2
gene_biotype: protein_coding
description:
  Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase; Adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol; Belongs to the ALG10 glucosyltransferase family.


ensembl_gene_id: Q59Z14
symbol: LIA1
gene_biotype: protein_coding
description:
  Deoxyhypusine hydroxylase; Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L- lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.


ensembl_gene_id: Q59Z17
symbol: DQD1
gene_biotype: protein_coding
description:
  Catabolic 3-dehydroquinase; Is involved in the catabolism of quinate. Allows the utilization of quinate as carbon source via the beta-ketoadipate pathway; Belongs to the type-II 3-dehydroquinase family.


ensembl_gene_id: Q59Z19
symbol: CaO19.2281
gene_biotype: protein_coding
description:
  Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.


ensembl_gene_id: Q59Z29
symbol: AFT2
gene_biotype: protein_coding
description:
  Iron-regulated transcriptional activator AFT2; Transcription factor involved in iron metabolism, oxidative stress, surface adhesion, hyphal development and virulence. Functions as a negative regulator of MRS4 expression through the CACCC AFT-type sequence in a gene dose-dependent fashion. Acts as a repressor in flocculation, plastic adhesion, and surface hydrophobicity.


ensembl_gene_id: Q59Z51
symbol: ATP23
gene_biotype: protein_coding
description:
  Mitochondrial inner membrane protease ATP23; Has a dual role in the assembly of mitochondrial ATPase. Acts as a protease that removes N-terminal residues of mitochondrial ATPase CF(0) subunit 6 at the intermembrane space side. Also involved in the correct assembly of the membrane-embedded ATPase CF(0) particle, probably mediating association of subunit 6 with the subunit 9 ring (By similarity); Belongs to the peptidase M76 family.


ensembl_gene_id: Q59ZB1
symbol: AAH1
gene_biotype: protein_coding
description:
  Adenine deaminase; Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.


ensembl_gene_id: Q59ZC8
symbol: FHL1
gene_biotype: protein_coding
description:
  Fork-head transcriptional regulator FHL1; In complex with IFH1, acts as a transcriptional regulator of rRNA and ribosomal protein genes. The FHL1-IFH1 complex is targeted to the ribosomal protein genes by the DNA-binding factor TBF1.


ensembl_gene_id: Q59ZE2
symbol: COQ5
gene_biotype: protein_coding
description:
  2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl- 6-methoxy-1,4-benzoquinol (DMQH2).


ensembl_gene_id: Q59ZH9
symbol: MAK5
gene_biotype: protein_coding
description:
  ATP-dependent RNA helicase MAK5; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs; Belongs to the DEAD box helicase family. DDX24/MAK5 subfamily.


ensembl_gene_id: Q59ZI0
symbol: BMT2
gene_biotype: protein_coding
description:
  25S rRNA adenine-N(1) methyltransferase; S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of an adenine present in helix 65 in 25S rRNA; Belongs to the BMT2 family.


ensembl_gene_id: Q59ZI3
symbol: GNT1
gene_biotype: protein_coding
description:
  Glucose N-acetyltransferase 1; N-acetylglucosaminyltransferase involved in the Golgi- specific modification of N-linked glycans; Belongs to the GNT1 family.


ensembl_gene_id: Q59ZU1
symbol: YPI2
gene_biotype: protein_coding
description:
  Type 1 phosphatases regulator YPI2; Regulator of type 1 phosphatases which maintains protein phosphatase activity under strict control; Belongs to the YPI1 family.


ensembl_gene_id: Q59ZV4
symbol: BNA7
gene_biotype: protein_coding
description:
  Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.


ensembl_gene_id: Q59ZV5
symbol: TIF35
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 3 subunit G; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA.


ensembl_gene_id: Q59ZW2
symbol: IML2
gene_biotype: protein_coding
description:
  Inclusion body clearance protein IML2; Inclusion body (IB) resident protein that interacts strongly with lipid droplet (LD) proteins. Involved in LD-mediated IB clearing after protein folding stress, probably by enabling access to the IBs of an LD-stored soluble sterol derivative that acts as chaperone in inclusion clearing.


ensembl_gene_id: Q59ZW4
symbol: YPI1
gene_biotype: protein_coding
description:
  Type 1 phosphatases regulator YPI1; Regulator of type 1 phosphatases which maintains protein phosphatase activity under strict control; Belongs to the YPI1 family.


ensembl_gene_id: Q59ZW9
symbol: PAM16
gene_biotype: protein_coding
description:
  Mitochondrial import inner membrane translocase subunit TIM16; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, it is required to regulate activity of mtHSP70 (SSC1) via its interaction with PAM18/TIM14. May act by positioning PAM18/TIM14 in juxtaposition to mtHSP70 at the translocon to maximize ATPase stimulation (By similarity); Belongs to the TIM16/PAM16 family.


ensembl_gene_id: Q59ZX3
symbol: RBE1
gene_biotype: protein_coding
description:
  Repressed by EFG1 protein 1; Cell wall protein involved in cell wall integrity and which plays a role in virulence.


ensembl_gene_id: Q59ZX6
symbol: UTP10
gene_biotype: protein_coding
description:
  U3 small nucleolar RNA-associated protein 10; Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in ribosome biosynthesis (By similarity).


ensembl_gene_id: Q59ZY9
symbol: NCS2
gene_biotype: protein_coding
description:
  Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.


ensembl_gene_id: Q59ZZ6
symbol: DEM1
gene_biotype: protein_coding
description:
  Exonuclease V, mitochondrial; Single strand DNA specific 5' exonuclease involved in mitochondrial DNA replication and recombination. Releases dinucleotides as main products of catalysis. Has the capacity to slide across 5'double-stranded DNA or 5'RNA sequences and resumes cutting two nucleotides downstream of the double-stranded-to-single-stranded junction or RNA-to-DNA junction, respectively (By similarity).


ensembl_gene_id: Q5A001
symbol: Q5A001_CANAL
gene_biotype: protein_coding
description:
  MFS domain-containing protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.


ensembl_gene_id: Q5A006
symbol: CaO19.4382
gene_biotype: protein_coding
description:
  Coatomer subunit zeta; The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.


ensembl_gene_id: Q5A013
symbol: EFM7
gene_biotype: protein_coding
description:
  Protein N-terminal and lysine N-methyltransferase EFM7; S-adenosyl-L-methionine-dependent protein methyltransferase that trimethylates the N-terminal glycine 'Gly-2' of elongation factor 1-alpha, before also catalyzing the mono- and dimethylation of 'Lys-3'. Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM7 family.


ensembl_gene_id: Q5A017
symbol: TAL1
gene_biotype: protein_coding
description:
  Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.


ensembl_gene_id: Q5A029
symbol: IFF3
gene_biotype: protein_coding
description:
  Cell wall protein IFF3; GPI-anchored cell wall protein involved in cell wall organization, hyphal growth, as well as in host-fungal interaction and virulence.


ensembl_gene_id: Q5A044
symbol: MIC60
gene_biotype: protein_coding
description:
  MICOS complex subunit MIC60; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway (By similarity).


ensembl_gene_id: Q5A061
symbol: PRP13
gene_biotype: protein_coding
description:
  Mitochondrial escape protein 2; Plays a role in maintaining the mitochondrial genome and in controlling the mtDNA escape. Involved in the regulation of mtDNA nucleotide structure and number. May have a dispensable role in early maturation of pre-rRNA (By similarity); Belongs to the YME2 family.


ensembl_gene_id: Q5A0A9
symbol: CLB4
gene_biotype: protein_coding
description:
  G2/mitotic-specific cyclin-4; 2/mitotic-specific cyclin essential for the control of the cell cycle at the G2/M (mitosis) transition. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis. Degradation is necessary for the cell to exit from mitosis. Plays a role in morphogenesis by negatively regulating polarized growth. Through binding to CDC28 regulates cytokinesis, partly by phosphorylation of the actomyosin ring component IQG1.


ensembl_gene_id: Q5A0E2
symbol: LOS1
gene_biotype: protein_coding
description:
  Exportin-T; tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease (By similarity); Belongs to the exportin family.


ensembl_gene_id: Q5A0E5
symbol: NRG1
gene_biotype: protein_coding
description:
  Transcriptional regulator NRG1; Transcriptional repressor that binds NRG1 response elements (NRE) of target promoters. Involved in regulation of chlamydospore formation, hyphal growth, virulence, and stress response. Plays a key role in regulating true hyphal growth, but does not regulate pseudohyphal growth in the same fashion. Directs transcriptional repression of a subset of filament-specific genes such as HWP1, HYR1, ALS8, HWP1, or ECE1; via the TUP1 pathway. Functions with UME6 in a negative feedback loop to control the level and duration of filament- specific gene expression in r [...]


ensembl_gene_id: Q5A0J9
symbol: ETT1
gene_biotype: protein_coding
description:
  Enhancer of translation termination 1; Required for correct translation termination and probably involved in regulation of hypoxic gene expression; Belongs to the ETT1 family.


ensembl_gene_id: Q5A0L7
symbol: SHE9
gene_biotype: protein_coding
description:
  Sensitive to high expression protein 9 homolog, mitochondrial; Required for the maintenance of the structure of the mitochondrial inner membrane. Involved in mitochondrial morphology. Causes growth arrest when highly overexpressed (By similarity).


ensembl_gene_id: Q5A0L9
symbol: SMP3
gene_biotype: protein_coding
description:
  GPI mannosyltransferase 4; Alpha-1,2-mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers a fourth mannose to trimannosyl-GPIs during GPI precursor assembly. The presence of a fourth mannose in GPI is essential in fungi (By similarity). Belongs to the glycosyltransferase 22 family. PIGZ subfamily.


ensembl_gene_id: Q5A0M4
symbol: EFT2
gene_biotype: protein_coding
description:
  Elongation factor 2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity).


ensembl_gene_id: Q5A0W6
symbol: CaO19.3130
gene_biotype: protein_coding
description:
  GPN-loop GTPase 3; Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family.


ensembl_gene_id: Q5A0W7
symbol: RVB1
gene_biotype: protein_coding
description:
  RuvB-like helicase 1; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity); Belongs to the RuvB family.


ensembl_gene_id: Q5A0W9
symbol: CZF1
gene_biotype: protein_coding
description:
  Zinc cluster transcription factor CZF1; Transcriptional regulator of the switch between 2 heritable states, the white and opaque states. These 2 cell types differ in many characteristics, including cell structure, mating competence, and virulence. Each state is heritable for many generations, and switching between states occurs stochastically, at low frequency. Contributes to formation of the opaque state, but is not necessary for heritability of the opaque state. Plays a role in cell adhesion and pseudohyphal growth. Involved in acquisition of drug resistance and acts as a repressor o [...]


ensembl_gene_id: Q5A0X8
symbol: CSA2
gene_biotype: protein_coding
description:
  Surface antigen protein 2; Secreted heme-binding protein involved in the utilization of iron from human hemoglobin during hyphal growth. May also play a role in non-hemoglobin iron utilization. The ability to acquire iron from host tissues is a major virulence factor of pathogenic microorganisms. Belongs to the RBT5 family.


ensembl_gene_id: Q5A0Y2
symbol: PUS5
gene_biotype: protein_coding
description:
  21S rRNA pseudouridine(2819) synthase; Pseudouridylate synthase responsible for the pseudouridine- 2819 formation in mitochondrial 21S rRNA. May modulate the efficiency or the fidelity of the mitochondrial translation machinery.


ensembl_gene_id: Q5A0Y8
symbol: MGT1
gene_biotype: protein_coding
description:
  Methylated-DNA--protein-cysteine methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.


ensembl_gene_id: Q5A0Z9
symbol: PDA1
gene_biotype: protein_coding
description:
  Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).


ensembl_gene_id: Q5A119
symbol: VID21
gene_biotype: protein_coding
description:
  Chromatin modification-related protein EAF1; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity).


ensembl_gene_id: Q5A1A0
symbol: MPH1
gene_biotype: protein_coding
description:
  ATP-dependent DNA helicase MPH1; ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork. Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily.


ensembl_gene_id: Q5A1B2
symbol: PGA42
gene_biotype: protein_coding
description:
  Probable cell wall protein PGA42; Probable GPI-anchored cell wall protein that may be involved in cell wall organization, hyphal growth, as well as in virulence. Belongs to the IHD1 family.


ensembl_gene_id: Q5A1B3
symbol: PGA41
gene_biotype: protein_coding
description:
  Probable cell wall protein PGA41; Probable GPI-anchored cell wall protein that may be involved in cell wall organization, hyphal growth, as well as in virulence. Belongs to the IHD1 family.


ensembl_gene_id: Q5A1D5
symbol: CDC68
gene_biotype: protein_coding
description:
  FACT complex subunit SPT16; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...]


ensembl_gene_id: Q5A1E0
symbol: IFF5
gene_biotype: protein_coding
description:
  Cell wall protein IFF5; GPI-anchored cell wall protein involved in cell wall organization, hyphal growth, as well as in host-fungal interaction and virulence; Belongs to the HYR1/IFF family.


ensembl_gene_id: Q5A1E1
symbol: PGA15
gene_biotype: protein_coding
description:
  Probable cell wall protein PGA15; Probable GPI-anchored cell wall protein that may be involved in cell wall organization, hyphal growth, as well as in virulence. Belongs to the IHD1 family.


ensembl_gene_id: Q5A1E3
symbol: CBF1
gene_biotype: protein_coding
description:
  Transcriptional regulator CBF1; Transcription factor that binds ribosomal protein gene promoters and rDNA locus with TBF1. Necessary for the expression of genes involved in assimilation of inorganic sulfate. Also required for the expression of respiratory genes and glycolytic genes. Does not bind to centromeres and is not necessary for efficient chromosome segregationas as does S.cerevisiae CBF1.


ensembl_gene_id: Q5A1E8
symbol: SDH12
gene_biotype: protein_coding
description:
  Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).


ensembl_gene_id: Q5A1L6
symbol: GIT3
gene_biotype: protein_coding
description:
  Major glycerophosphoinositol permease GIT3; Glycerophosphodiester transporter that mediates uptake of glycerophosphocholine (GroPCho) with GIT4. GIT3 acts as the major GroPCho permease. Does not possess detectable glycerophosphoinositol (GroPIns) transport activity. The expanded ability to utilize GroPIns and GroPCho results from the organism's pathogenic nature and its need to occupy a variety of environments within its host organism. This possibility is buttressed by the fact that GroPIns and GroPCho are present and abundant in human fluids.


ensembl_gene_id: Q5A1M0
symbol: CaO19.1975
gene_biotype: protein_coding
description:
  Spliceosomal protein DIB1; Essential role in pre-mRNA splicing. Also essential for entry into mitosis (G2/M progression) as well as for chromosome segregation during mitosis; Belongs to the DIM1 family.


ensembl_gene_id: Q5A1M3
symbol: SET5
gene_biotype: protein_coding
description:
  Potential protein lysine methyltransferase SET5; Putative protein lysine methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET5 subfamily.


ensembl_gene_id: Q5A1M4
symbol: TRY3
gene_biotype: protein_coding
description:
  Transcriptional regulator of yeast form adherence 3; Transcription factor required for yeast cell adherence to silicone substrate.


ensembl_gene_id: Q5A1N6
symbol: CLN3
gene_biotype: protein_coding
description:
  G1/S-specific cyclin CLN3; G1/S-specific cyclin essential for the control of the cell cycle at the G1/S (start) transition. CLN3 may be an upstream activator of the G1 cyclins which directly catalyze start. Required for budding and for cell cycle progression and morphogenesis in environment-induced hyphae. Degradation is mediated by GRR1. Through binding to CDC28, controls the phosphorylation of SLA1 which regulates cortical actin patch dynamics.


ensembl_gene_id: Q5A1Q0
symbol: CaO19.1946
gene_biotype: protein_coding
description:
  Glucose-6-phosphate 1-epimerase; Catalyzes the interconversion between the alpha and beta anomers from at least three hexose 6-phosphate sugars (Glc6P, Gal6P, and Man6P).


ensembl_gene_id: Q5A1Q5
symbol: NUF2
gene_biotype: protein_coding
description:
  Probable kinetochore protein NUF2; Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.


ensembl_gene_id: Q5A1U8
symbol: ERF4
gene_biotype: protein_coding
description:
  Ras modification protein ERF4; The ERF2-ERF4 complex is a palmitoyltransferase specific for Ras proteins. Palmitoylates RAS2, which is required for its proper plasma membrane localization (By similarity).


ensembl_gene_id: Q5A1V3
symbol: POA1
gene_biotype: protein_coding
description:
  ADP-ribose 1''-phosphate phosphatase; Highly specific phosphatase involved in the metabolism of ADP-ribose 1''-phosphate (Appr1p) which is produced as a consequence of tRNA splicing; Belongs to the POA1 family.


ensembl_gene_id: Q5A1W9
symbol: HST3
gene_biotype: protein_coding
description:
  NAD-dependent histone deacetylase HST3; NAD-dependent histone deacetylase, which could function in telomeric silencing, cell cycle progression and chromosome stability. Belongs to the sirtuin family. Class I subfamily.


ensembl_gene_id: Q5A1Z5
symbol: ATG13
gene_biotype: protein_coding
description:
  Autophagy-related protein 13; Activates the ATG1 kinase in a nutritional condition dependent manner through the TOR pathway, leading to autophagy. Also involved in cytoplasm to vacuole transport (Cvt) and more specifically in Cvt vesicle formation. Seems to play a role in the switching machinery regulating the conversion between the Cvt pathway and autophagy. Finally, ATG13 is also required for glycogen storage during stationary phase (By similarity).


ensembl_gene_id: Q5A201
symbol: GZF3
gene_biotype: protein_coding
description:
  Transcriptional regulator GZF3; Probable transcription factor involved in response to fluconazole, LiCl, and copper.


ensembl_gene_id: Q5A207
symbol: CaO19.2836
gene_biotype: protein_coding
description:
  Carbonic anhydrase; Reversible hydration of carbon dioxide. Belongs to the beta-class carbonic anhydrase family.


ensembl_gene_id: Q5A210
symbol: PGA34
gene_biotype: protein_coding
description:
  Predicted GPI-anchored protein 34; Predicted GPI-anchored protein which may have a role during host infection.


ensembl_gene_id: Q5A216
symbol: NDC80
gene_biotype: protein_coding
description:
  Probable kinetochore protein NDC80; Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.


ensembl_gene_id: Q5A218
symbol: DRE2
gene_biotype: protein_coding
description:
  Fe-S cluster assembly protein DRE2; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by  [...]


ensembl_gene_id: Q5A220
symbol: RFG1
gene_biotype: protein_coding
description:
  Repressor of filamentous growth 1; Transcription regulator that functions in both the positive and negative regulation of filamentous growth, depending upon the environmental conditions. Recruits the TUP1/SSN6 general repression complex to achieve repression. Regulates genes encoding cell wall components that are specifically expressed in the filamentous forms such as HWP1, RBT1, HYR1, ECE1, ALS1, RBT4 and RBT5.


ensembl_gene_id: Q5A222
symbol: CaO19.2821
gene_biotype: protein_coding
description:
  NADH-ubiquinone oxidoreductase; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.


ensembl_gene_id: Q5A246
symbol: RPC82
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerase III subunit RPC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs (By similarity).


ensembl_gene_id: Q5A287
symbol: SFL1
gene_biotype: protein_coding
description:
  Transcription factor SFL1; Transcription factor that plays a role of repressor of filamentous growth and flocculation. Antagonizes functions of SFL2 and FLO8. Plays a role in the hyphal repression induced by secreted factors like dodecanol by competitors such as Pseudomonas aeruginosa and Burkholderia cenocepacia.


ensembl_gene_id: Q5A2A2
symbol: MHR1
gene_biotype: protein_coding
description:
  Mitochondrial homologous recombination protein 1; Transcription factor involved in regulation of RNA polymerase II-dependent transcription. Also involved in regulation of mitochondrial DNA recombination, maintenance and repair, and generation of homoplasmic cells (By similarity); Belongs to the mitochondrion-specific ribosomal protein mL67 family.


ensembl_gene_id: Q5A2B9
symbol: SPT20
gene_biotype: protein_coding
description:
  Transcription factor SPT20; Component of the transcription regulatory histone acetylation (HAT) complex SAGA. SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. SAGA acetylates nucleosom [...]


ensembl_gene_id: Q5A2J7
symbol: YVC1
gene_biotype: protein_coding
description:
  Calcium channel YVC1; Vacuolar calcium channel involved in the release of calcium ions from the vacuole in response to hyperosmotic or alkaline stress. Required for activation of CAP1-related transcription of oxidative stress response (OSR) genes, but also for maintaining the stability of both the mitochondria and the vacuole in a potassium- and calcium- dependent manner. Contributes to pathogenicity. Plays a key role in hyphal polarized growth and re-orientation to host-signals through its contribution to the localization of the Spitzenkoerper to the hyphal tips; Belongs to the transi [...]


ensembl_gene_id: Q5A2K0
symbol: NST1
gene_biotype: protein_coding
description:
  Stress response protein NST1; May act as a negative regulator of salt tolerance. Belongs to the NST1 family.


ensembl_gene_id: Q5A2U9
symbol: VMA5
gene_biotype: protein_coding
description:
  V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.


ensembl_gene_id: Q5A2V2
symbol: RMD9
gene_biotype: protein_coding
description:
  Protein RMD9, mitochondrial; Involved in the processing or stability of mitochondrial mRNAs. Required for meiotic nuclear division (By similarity). Belongs to the RMD9 family.


ensembl_gene_id: Q5A2W2
symbol: DML1
gene_biotype: protein_coding
description:
  Protein DML1; Involved in the partitioning of the mitochondrial organelle and mitochondrial DNA (mtDNA) inheritance; Belongs to the misato family.


ensembl_gene_id: Q5A2Y7
symbol: NSA2
gene_biotype: protein_coding
description:
  Ribosome biogenesis protein NSA2; Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles (By similarity).


ensembl_gene_id: Q5A2Z1
symbol: MED6
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 6; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).


ensembl_gene_id: Q5A2Z7
symbol: ALS6
gene_biotype: protein_coding
description:
  Agglutinin-like protein 6; Cell surface adhesion protein which mediates both yeast-to- host tissue adherence and yeast aggregation. Plays an important role in the pathogenesis of C.albicans infections.


ensembl_gene_id: Q5A301
symbol: CYM1
gene_biotype: protein_coding
description:
  Mitochondrial presequence protease; ATP-independent protease that degrades mitochondrial transit peptides after their cleavage. Also degrades other unstructured peptides (By similarity); Belongs to the peptidase M16 family. PreP subfamily.


ensembl_gene_id: Q5A302
symbol: ERV25
gene_biotype: protein_coding
description:
  Endoplasmic reticulum vesicle protein 25; Constituent of COPII-coated endoplasmic reticulum-derived transport vesicles. Required for efficient transport of a subset of secretory proteins to the Golgi. Facilitates retrograde transport from the Golgi to the endoplasmic reticulum (By similarity); Belongs to the EMP24/GP25L family.


ensembl_gene_id: Q5A309
symbol: DOT1
gene_biotype: protein_coding
description:
  Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.


ensembl_gene_id: Q5A310
symbol: ISW2
gene_biotype: protein_coding
description:
  ISWI chromatin-remodeling complex ATPase ISW2; Catalytic component of the ISW2 complex, which acts in remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. The ISW2 complex is involved in coordinating transcriptional repression and in inheritance of telomeric silencing (By similarity). ISW2 is required for chlamydospore formation, distinctive morphological feature of the fungal pathogen C.albicans that can be induced to form in oxygen-limited environments and has been reported in clinical specimens; Belongs to the SNF2/RAD54 helicase fa [...]


ensembl_gene_id: Q5A312
symbol: ALS7
gene_biotype: protein_coding
description:
  Agglutinin-like protein 7; Cell surface adhesion protein which mediates both yeast-to- host tissue adherence and yeast aggregation. Plays an important role in the pathogenesis of C.albicans infections. Belongs to the ALS family.


ensembl_gene_id: Q5A319
symbol: NPR3
gene_biotype: protein_coding
description:
  Nitrogen permease regulator 3; Mediates inactivation of the TORC1 complex in response to amino acid starvation. Required for meiotic nuclear division (By similarity).


ensembl_gene_id: Q5A341
symbol: SSY5
gene_biotype: protein_coding
description:
  SPS-sensor serine protease component SSY5; Protease component of the SPS-sensor system, which regulates the expression of several amino acid-metabolizing enzymes and amino acid- and peptide-permeases in response to extracellular amino acid levels by controlling the activity of two transcription factors, STP1 and STP2. Catalyzes the activation of these transcription factors, which are synthesized as latent cytoplasmic precursors, by proteolytic removal of an N-terminal inhibitory domain containing cytoplasmic retention motifs. SSY5 binds as an inactive protease complex to STP1. In respo [...]


ensembl_gene_id: Q5A343
symbol: PGA13
gene_biotype: protein_coding
description:
  GPI-anchored protein 13; Cell wall protein which contributes to cell wall synthesis and is important for acquiring normal surface properties. Required for virulence in a mouse infection model.


ensembl_gene_id: Q5A357
symbol: CaO19.6406
gene_biotype: protein_coding
description:
  Putative mitochondrial 37S ribosomal protein SWS2; Belongs to the universal ribosomal protein uS13 family.


ensembl_gene_id: Q5A360
symbol: SIL1
gene_biotype: protein_coding
description:
  Nucleotide exchange factor SIL1; Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone KAR2 (By similarity).


ensembl_gene_id: Q5A368
symbol: NTE1
gene_biotype: protein_coding
description:
  Lysophospholipase NTE1; Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium (By similarity); Belongs to the NTE family.


ensembl_gene_id: Q5A387
symbol: PPM1
gene_biotype: protein_coding
description:
  Leucine carboxyl methyltransferase 1; Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha- leucine ester residues; Belongs to the methyltransferase superfamily. LCMT family.


ensembl_gene_id: Q5A3J1
symbol: MRPL51
gene_biotype: protein_coding
description:
  54S ribosomal protein L51, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mL43 family.


ensembl_gene_id: Q5A3K2
symbol: NUT2
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 10; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).


ensembl_gene_id: Q5A3K7
symbol: SER33
gene_biotype: protein_coding
description:
  D-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.


ensembl_gene_id: Q5A3L0
symbol: RPN2
gene_biotype: protein_coding
description:
  26S proteasome regulatory subunit RPN2; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.


ensembl_gene_id: Q5A3M6
symbol: MCD4
gene_biotype: protein_coding
description:
  GPI ethanolamine phosphate transferase 1; Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor (By similarity).


ensembl_gene_id: Q5A3P6
symbol: PKH2
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase PKH2; Serine/threonine-protein kinase which is part sphingolipid- mediated signaling pathway that is required for the internalization step of endocytosis by regulating eisosome assembly and organization, and modulating the organization of the plasma membrane. Phosphorylates and activates PKC1. Activates YPK1 and YPK2, 2 components of signaling cascade required for maintenance of cell wall integrity. Required for stress-induced P-body assembly and regulates global mRNA decay at the deadenylation step; Belongs to the protein kinase superfamily. AGC Ser/Thr [...]


ensembl_gene_id: Q5A3Q0
symbol: REX4
gene_biotype: protein_coding
description:
  RNA exonuclease 4; Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs (By similarity); Belongs to the REXO4 family.


ensembl_gene_id: Q5A3V6
symbol: RIB3
gene_biotype: protein_coding
description:
  3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family.


ensembl_gene_id: Q5A3Y5
symbol: THI13
gene_biotype: protein_coding
description:
  4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase; Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway. Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP). The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. Belongs to the NMT1/THI5 family.


ensembl_gene_id: Q5A3Z5
symbol: CDG1
gene_biotype: protein_coding
description:
  Cysteine dioxygenase CDG1; Cysteine dioxygenase involved in sulfite formation from cysteine. Plays an important role in filamentous growth and virulence.


ensembl_gene_id: Q5A3Z6
symbol: SSU1
gene_biotype: protein_coding
description:
  Sulfite efflux pump SSU1; Sulfite efflux pump required for the secretion of sulfite as a reducing agent (By similarity). Plays a role in resistance to neutrophils during infection. Involved in transition to filamentous growth, which is believed to be central to the virulence of this human pathogen. Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.


ensembl_gene_id: Q5A416
symbol: TRM61
gene_biotype: protein_coding
description:
  tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61; Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.


ensembl_gene_id: Q5A432
symbol: GAT1
gene_biotype: protein_coding
description:
  Transcriptional regulatory protein GAT1; Transcriptional regulator of nitrogen utilization required for nitrogen catabolite repression and utilization of isoleucine, tyrosine and tryptophan as nitrogen sources. Controls expression of the MEP2 ammonium permease, the DUR1,2 urea amidolyase, and the transcription factor STP1, which in turn mediates SAP2 expression, a long-known virulence attribute of C.albicans. Influences the filamentation process depending upon the nitrogen sources available. Required for virulence in a mouse systemic infection model.


ensembl_gene_id: Q5A435
symbol: CaO19.1273
gene_biotype: protein_coding
description:
  Prefoldin subunit 4; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins; Belongs to the prefoldin subunit beta family.


ensembl_gene_id: Q5A446
symbol: CFL1
gene_biotype: protein_coding
description:
  Ferric/cupric reductase transmembrane component 1; Ferric reductase responsible for reducing extracellular iron and copper prior to import. Catalyzes the reductive uptake of Fe(3+)- salts and Fe(3+) bound to catecholate or hydroxamate siderophores. Fe(3+) is reduced to Fe(2+), which then dissociates from the siderophore and can be imported by the high-affinity Fe(2+) transport complex in the plasma membrane. Also participates in Cu(2+) reduction and Cu(+) uptake (By similarity). Involved in maintenance of cell wall integrity (CWI), mitochondrial function, and interaction between the pa [...]


ensembl_gene_id: Q5A455
symbol: SEC23
gene_biotype: protein_coding
description:
  Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity).


ensembl_gene_id: Q5A477
symbol: VRG4
gene_biotype: protein_coding
description:
  GDP-mannose transporter; Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen. Involved in hyphal formation.


ensembl_gene_id: Q5A4E2
symbol: DED1
gene_biotype: protein_coding
description:
  ATP-dependent RNA helicase DED1; ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity). Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.


ensembl_gene_id: Q5A4E3
symbol: OCH1
gene_biotype: protein_coding
description:
  Initiation-specific alpha-1,6-mannosyltransferase; Mannosyltransferase involved in outer chain elongation of asparagine-linked oligosaccharides of the type Man(9)GlcNAc(2). Adds the first alpha-1,6-mannose to the Man(8)GlcNAc(2) and Man(9)GlcNAc(2), but not Man(5)GlcNAc(2), endoplasmic reticulum intermediates (By similarity). Represents the first enzymatic event required for synthesis of outer chain mannose linkages on yeast secretory proteins. N-glycan outer chain epitopes play a crucial role in the host-fungal interaction, virulence, and host immune response such as interleukin synth [...]


ensembl_gene_id: Q5A4F3
symbol: AHR1
gene_biotype: protein_coding
description:
  Adhesion and hyphal regulator 1; Transcription factor that binds the promoters of genes involved in biofilm formation, which include several key adhesion genes, and recruits MCM1 to these sites. Plays an important role in hyphal growth and virulence. Promotes conversion of opaque cells to white phase, but needs existence of EFG1, a key regulator required for maintenance of the white state.


ensembl_gene_id: Q5A4G2
symbol: MRR1
gene_biotype: protein_coding
description:
  Multidrug resistance regulator 1; Transcription factor that acts as the central regulator of the MDR1 efflux pump. Other target genes include those encoding oxidoreductases, whose up-regulation in fluconazole-resistant isolates may help to prevent cell damage resulting from the generation of toxic molecules in the presence of fluconazole and thereby contribute to drug resistance.


ensembl_gene_id: Q5A4G9
symbol: FYV10
gene_biotype: protein_coding
description:
  Protein FYV10; Involved in the proteasome-dependent degradation of fructose- 1,6-bisphosphatase; Belongs to the FYV10 family.


ensembl_gene_id: Q5A4H4
symbol: SGF11
gene_biotype: protein_coding
description:
  SAGA-associated factor 11; Functions as component of the transcription regulatory histone acetylation (HAT) complex SAGA. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA [...]


ensembl_gene_id: Q5A4H5
symbol: CRZ1
gene_biotype: protein_coding
description:
  Transcriptional regulator CRZ1; Transcription factor involved in the regulation of calcium ion homeostasis and required for the maintenance of membrane integrity. Binds to the calcineurin-dependent response element. Plays a role in azole tolerance.


ensembl_gene_id: Q5A4H9
symbol: SSN8
gene_biotype: protein_coding
description:
  RNA polymerase II holoenzyme cyclin-like subunit; Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II (By s [...]


ensembl_gene_id: Q5A4J4
symbol: PBN1
gene_biotype: protein_coding
description:
  Protein PBN1; Required for proper folding and/or the stability of a subset of proteins in the endoplasmic reticulum. Component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase GPI14 (By similarity).


ensembl_gene_id: Q5A4K7
symbol: TRY5
gene_biotype: protein_coding
description:
  Transcriptional regulator of yeast form adherence 5; Transcription factor required for yeast cell adherence to silicone substrate.


ensembl_gene_id: Q5A4M8
symbol: SUR7
gene_biotype: protein_coding
description:
  Protein SUR7; Involved in cell wall, plasma membrane, and cytoskeletal organization. Plays a role in endocytosis and hyphal morphogenesis. Required to restrict septin proteins to the bud neck and prevents intracellular growth of cell wall. Contributes to secretion, biofilm formation, and macrophage killing. Essential for resistance to stressful conditions and for invasive growth and virulence. Belongs to the SUR7 family.


ensembl_gene_id: Q5A4N0
symbol: ATG15
gene_biotype: protein_coding
description:
  Putative lipase ATG15; Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by ATG15 is critical to life span extension (By similarity); Belongs to the AB hydrolase superfamily. Lipase family.


ensembl_gene_id: Q5A4N5
symbol: RAD18
gene_biotype: protein_coding
description:
  Postreplication repair E3 ubiquitin-protein ligase RAD18; E3 RING-finger protein, member of the UBC2/RAD6 epistasis group. Associates to the E2 ubiquitin conjugating enzyme UBC2/RAD6 to form the UBC2-RAD18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA.


ensembl_gene_id: Q5A4P2
symbol: COQ3
gene_biotype: protein_coding
description:
  Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.


ensembl_gene_id: Q5A4P9
symbol: DBP9
gene_biotype: protein_coding
description:
  ATP-dependent RNA helicase DBP9; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs; Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily.


ensembl_gene_id: Q5A4Q1
symbol: ADK1
gene_biotype: protein_coding
description:
  Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.


ensembl_gene_id: Q5A4W7
symbol: FAS1
gene_biotype: protein_coding
description:
  3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The beta subunit contains domains for: [acyl-carrier-protein] acetyltransferase and malonyltransferase, S-acyl fatty acid synthase thioesterase, enoyl- [acyl-carrier-protein] reductase, and 3-hydroxypalmitoyl-[acyl-carrier- protein] dehydratase.


ensembl_gene_id: Q5A4W8
symbol: BDF1
gene_biotype: protein_coding
description:
  Bromodomain-containing factor 1; Transcription factor involved in the expression of a broad class of genes including snRNAs. Required for sporulation and DNA- damage repair. Prevents the spreading of SIR silencing at telomeres and protects histone H4, but not H3, from deacetylation (By similarity).


ensembl_gene_id: Q5A4X0
symbol: BRE1
gene_biotype: protein_coding
description:
  E3 ubiquitin-protein ligase BRE1; E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation; Belongs to the BRE1 family.


ensembl_gene_id: Q5A4X4
symbol: SLX1
gene_biotype: protein_coding
description:
  Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.


ensembl_gene_id: Q5A4X5
symbol: SKN7
gene_biotype: protein_coding
description:
  Transcription factor SKN7; Transcription factor that is part of a SLN1-YPD1-SKN7 two- component regulatory system, which controls gene expression in response to changes in the osmolarity of the extracellular environment. Under low osmotic conditions, phosphorylated and activated by the phosphorelay intermediate protein YPD1. Also activated in response to oxidative stress, independent on the two-component regulatory system. Regulates heat shock genes in response to oxidative stress and genes involved in cell wall integrity in response to osmotic changes.


ensembl_gene_id: Q5A4X8
symbol: PGA14
gene_biotype: protein_coding
description:
  Hydrophilin PGA14; Hydrophilin which is essential to overcome the simple stress of the desiccation-rehydration process; Belongs to the PGA14 family.


ensembl_gene_id: Q5A4Y0
symbol: DUS4
gene_biotype: protein_coding
description:
  tRNA-dihydrouridine synthase; Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs; Belongs to the dus family.


ensembl_gene_id: Q5A506
symbol: BUD2
gene_biotype: protein_coding
description:
  GTPase activating protein BUD2; GTPase activating protein (GAP) for RSR1 which is involved in the polarization of yeast and hyphal cells. Directs the site of new daughter cell growth in yeast and hyphal cells. Important for hyphae to maintain linear growth and necessary for hyphal responses to directional cues in the environment (tropisms). Required for correct localization of the septin rings and stabilization of the polarisome at hyphal tips. Involved in cell adhesion.


ensembl_gene_id: Q5A519
symbol: CGI121
gene_biotype: protein_coding
description:
  EKC/KEOPS complex subunit CGI121; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. CGI121 acts as an allosteric effector that regulates the t(6)A activity of the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transc [...]


ensembl_gene_id: Q5A599
symbol: NIK1
gene_biotype: protein_coding
description:
  Histidine protein kinase NIK1; Histidine kinase involved in a two-component signaling pathway that regulates cell wall mannan biosynthesis. Required for hyphal formation and virulence. Plays a role in fungicides sensitivity, probably through the positive regulation of the HOG1-signaling pathway. Presumed to mediate phosphotransfer to the HOG1 MAP kinase pathway during oxidative and perhaps osmotic stress.


ensembl_gene_id: Q5A5K7
symbol: PGA28
gene_biotype: protein_coding
description:
  Probable GPI-anchored adhesin-like protein PGA28; Putative adhesin which is involved in cell adhesion and virulence (By similarity). Plays a role in Candida-bacterial interactions and subsequent regulation of filamentation.


ensembl_gene_id: Q5A5M7
symbol: RBR3
gene_biotype: protein_coding
description:
  Cell wall protein RBR3; GPI-anchored cell wall protein involved in cell wall organization, hyphal growth, as well as in host-fungal interaction and virulence; Belongs to the HYR1/IFF family.


ensembl_gene_id: Q5A5N5
symbol: SLT11
gene_biotype: protein_coding
description:
  Pre-mRNA-splicing factor SLT11; Involved in pre-mRNA splicing. Facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome. Binds to RNA (By similarity).


ensembl_gene_id: Q5A5N6
symbol: ALG14
gene_biotype: protein_coding
description:
  UDP-N-acetylglucosamine transferase subunit ALG14; Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway. Anchors the catalytic subunit ALG13 to the ER (By similarity).


ensembl_gene_id: Q5A5P8
symbol: TIF11
gene_biotype: protein_coding
description:
  Tif11p; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.


ensembl_gene_id: Q5A5Q6
symbol: ASH1
gene_biotype: protein_coding
description:
  Transcriptional regulatory protein ASH1; Component of the RPD3C(L) histone deacetylase complex (HDAC). Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Controls filamentous growth and required for full virulence in a mouse model of disseminated candidiasis.


ensembl_gene_id: Q5A5S7
symbol: ATG27
gene_biotype: protein_coding
description:
  Autophagy-related protein 27; Effector of VPS34 phosphatidylinositol 3-phosphate kinase signaling. Regulates the cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a role in ATG protein retrieval from the pre- autophagosomal structure (PAS) and is especially required for autophagy-dependent cycling of ATG9 (By similarity); Belongs to the ATG27 family.


ensembl_gene_id: Q5A5U4
symbol: RHD3
gene_biotype: protein_coding
description:
  Cell wall protein RHD3; Component of the cell wall involved in virulence. Does not seem to have a major role in maintaining cell wall integrity but plays a role in the relationship between C.albicans and the host. Belongs to the SRP1/TIP1 family.


ensembl_gene_id: Q5A5U6
symbol: PGA30
gene_biotype: protein_coding
description:
  Cell wall protein PGA30; Component of the cell wall involved in virulence which plays a role in the relationship between C.albicans and the host. Belongs to the SRP1/TIP1 family.


ensembl_gene_id: Q5A5U9
symbol: PGA31
gene_biotype: protein_coding
description:
  Cell wall protein PGA31; Component of the cell wall involved in virulence which plays a role in the relationship between C.albicans and the host (By similarity). Involved in the regulation or assembly of chitin within the cell wall.


ensembl_gene_id: Q5A5V6
symbol: PDB1
gene_biotype: protein_coding
description:
  Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.


ensembl_gene_id: Q5A644
symbol: LYS4
gene_biotype: protein_coding
description:
  Homoaconitase, mitochondrial; Catalyzes the reversible hydration of cis-homoaconitate to (2R,3S)-homoisocitrate, a step in the alpha-aminoadipate pathway for lysine biosynthesis.


ensembl_gene_id: Q5A649
symbol: ATG1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase ATG1; Serine/threonine protein kinase involved in the cytoplasm to vacuole transport (Cvt) and found to be essential in autophagy, where it is required for the formation of autophagosomes. Involved in the clearance of protein aggregates which cannot be efficiently cleared by the proteasome. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing [...]


ensembl_gene_id: Q5A651
symbol: SAP10
gene_biotype: protein_coding
description:
  Candidapepsin-10; Secreted aspartic peptidases (SAPs) are a group of ten acidic hydrolases considered as key virulence factors. These enzymes supply the fungus with nutrient amino acids as well as are able to degrade the selected host's proteins involved in the immune defense. Required for cell surface integrity and cell separation during budding.


ensembl_gene_id: Q5A653
symbol: EFM5
gene_biotype: protein_coding
description:
  Protein-lysine N-methyltransferase EFM5; S-adenosyl-L-methionine-dependent protein-lysine N- methyltransferase that trimethylates elongation factor 1-alpha at 'Lys- 79'; Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.


ensembl_gene_id: Q5A660
symbol: PXR1
gene_biotype: protein_coding
description:
  Protein PXR1; Involved in rRNA-processing at A0, A1 and A2 sites and regulates negatively telomerase; Belongs to the PINX1 family.


ensembl_gene_id: Q5A668
symbol: SCS7
gene_biotype: protein_coding
description:
  Ceramide very long chain fatty acid hydroxylase; Ceramide hydroxylase involved in the hydroxylation of sphingolipid-associated very long chain fatty acids. Postulated to hydroxylate the very long chain fatty acid of dihydroceramides and phytoceramides at C-2; Belongs to the sterol desaturase family. SCS7 subfamily.


ensembl_gene_id: Q5A687
symbol: MNN22
gene_biotype: protein_coding
description:
  Alpha-1,2-mannosyltransferase MNN22; Alpha-1,2-mannosyltransferase required for cell wall integrity. Responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides. Addition of alpha-1,2-mannose is required for stabilization of the alpha-1,6-mannose backbone and hence regulates mannan fibril length; and is important for both immune recognition and virulence; Belongs to the MNN1/MNT family.


ensembl_gene_id: Q5A688
symbol: PMT6
gene_biotype: protein_coding
description:
  Dolichyl-phosphate-mannose--protein mannosyltransferase 6; Protein mannosyltransferase (PMT) involved in hyphal morphogenesis and drug sensitivity. Transfers mannose from Dol-P- mannose to Ser or Thr residues on proteins. PMT1, PMT2 and PMT4 account for most of the protein-O-glycosylation activity, while PMT5 and PMT6 may specifically modulate a much narrower spectrum of target proteins. Required for biofilm formation and virulence.


ensembl_gene_id: Q5A692
symbol: TRM8
gene_biotype: protein_coding
description:
  tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.


ensembl_gene_id: Q5A6A4
symbol: KAE1
gene_biotype: protein_coding
description:
  tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. Th [...]


ensembl_gene_id: Q5A6B6
symbol: PPG1
gene_biotype: protein_coding
description:
  Serine/threonine-protein phosphatase PP2A-like PPG1; Serine/threonine-protein phosphatase that plays an important role in controlling colony morphology, filament extension and agar invasion. Down-regulates expression of NRG1 and affects the expression of multiple filament-specific transcripts in response to serum and 37 degrees Celsius. Plays a crucial role in virulence in a mouse model of systemic candidiasis; Belongs to the PPP phosphatase family. PP-2A subfamily.


ensembl_gene_id: Q5A6K2
symbol: ATG22
gene_biotype: protein_coding
description:
  Autophagy-related protein 22; May be required for lysis of autophagic vesicles after delivery to the vacuole; Belongs to the ATG22 family.


ensembl_gene_id: Q5A6K8
symbol: RAD27
gene_biotype: protein_coding
description:
  Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as  [...]


ensembl_gene_id: Q5A6L5
symbol: LAP3
gene_biotype: protein_coding
description:
  Cysteine proteinase 1, mitochondrial; Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity.


ensembl_gene_id: Q5A6M2
symbol: RBR2
gene_biotype: protein_coding
description:
  Repressed By RIM101 protein 2; Probable cell wall protein which may have esterase activity, with a preference for esters of fatty acids from 4 to 16 carbon atoms. Belongs to the SRP1/TIP1 family.


ensembl_gene_id: Q5A6M9
symbol: NHP2
gene_biotype: protein_coding
description:
  Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family.


ensembl_gene_id: Q5A6N1
symbol: PIM1
gene_biotype: protein_coding
description:
  Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family.


ensembl_gene_id: Q5A6N8
symbol: RFT1
gene_biotype: protein_coding
description:
  Oligosaccharide translocation protein RFT1; May participate in the translocation of oligosaccharide from the cytoplasmic side to the lumenal side of the endoplasmic reticulum membrane; Belongs to the RFT1 family.


ensembl_gene_id: Q5A6P2
symbol: NAT10
gene_biotype: protein_coding
description:
  RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein TAN1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.


ensembl_gene_id: Q5A6P6
symbol: QDR
gene_biotype: protein_coding
description:
  MFS antiporter QDR1; MFS antiporter that does not display functional linkage as drug transporter and performs functions that significantly affect biofilm development and virulence. No substrate for transport has been identified yet, but plays an important role in the growth in the host. Belongs to the major facilitator superfamily. CAR1 family.


ensembl_gene_id: Q5A6Q4
symbol: TRM6
gene_biotype: protein_coding
description:
  tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6; Substrate-binding subunit of tRNA (adenine-N(1)-)- methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.


ensembl_gene_id: Q5A6Q7
symbol: EAF7
gene_biotype: protein_coding
description:
  Chromatin modification-related protein EAF7; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity).


ensembl_gene_id: Q5A6U1
symbol: IFF9
gene_biotype: protein_coding
description:
  Cell wall protein IFF9; GPI-anchored cell wall protein involved in cell wall organization, hyphal growth, as well as in host-fungal interaction and virulence; Belongs to the HYR1/IFF family.


ensembl_gene_id: Q5A723
symbol: MON1
gene_biotype: protein_coding
description:
  Vacuolar fusion protein MON1; Required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis; Belongs to the MON1/SAND family.


ensembl_gene_id: Q5A748
symbol: SNX3
gene_biotype: protein_coding
description:
  Sorting nexin-3; Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)) (By similarity).


ensembl_gene_id: Q5A750
symbol: TKL1
gene_biotype: protein_coding
description:
  Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.


ensembl_gene_id: Q5A761
symbol: CCR4
gene_biotype: protein_coding
description:
  Glucose-repressible alcohol dehydrogenase transcriptional effector; Acts as catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. Ccr4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single-stranded DNA. Discovered because of its role in the control of ADH2 gene expression. It is required for the expression of genes involved in non-fermentative growth (By similarity); Belongs to  [...]


ensembl_gene_id: Q5A762
symbol: MLT1
gene_biotype: protein_coding
description:
  Multiple drug resistance-associated protein-like transporter 1; Vacuolar multi-drug resistance ABC transporter that may be involved in the transport of bilirubin and glutathione conjugates (By similarity). Plays an important role in virulence.


ensembl_gene_id: Q5A786
symbol: PFY1
gene_biotype: protein_coding
description:
  Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.


ensembl_gene_id: Q5A7M2
symbol: TIM44
gene_biotype: protein_coding
description:
  Mitochondrial import inner membrane translocase subunit TIM44; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the Tim44 family.


ensembl_gene_id: Q5A7M3
symbol: BNA4
gene_biotype: protein_coding
description:
  Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.


ensembl_gene_id: Q5A7N3
symbol: MZM1
gene_biotype: protein_coding
description:
  Mitochondrial zinc maintenance protein 1, mitochondrial; Assembly factor required for Rieske Fe-S protein RIP1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane. Modulates the mitochondrial matrix zinc pool (By similarity).


ensembl_gene_id: Q5A7P3
symbol: EST3
gene_biotype: protein_coding
description:
  Telomere replication protein EST3; Component of the telomerase complex involved in telomere replication. Stimulates RNA/DNA heteroduplex unwinding which favors the telomere replication by the telomerase (By similarity).


ensembl_gene_id: Q5A7Q2
symbol: ESA1
gene_biotype: protein_coding
description:
  Histone acetyltransferase ESA1; Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, histone H2B to form H2BK16ac, and histone H2A to form H2AK4ac and H2AK7ac. Acetylation of histone H4 is essential for DNA double- strand break repair through homologous recombination. Involved in cell cycle progression. Recru [...]


ensembl_gene_id: Q5A7Q3
symbol: PRP46
gene_biotype: protein_coding
description:
  Pre-mRNA-splicing factor PRP46; Involved in pre-mRNA splicing and required for cell cycle progression at G2/M.


ensembl_gene_id: Q5A7Q6
symbol: PAC1
gene_biotype: protein_coding
description:
  Nuclear distribution protein PAC1; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. Plays a central role in positioning the mitotic spindle at the bud neck during cell division. Targets cytoplasmic dynein to microtubule plus ends, thereby promoting dynein- mediated microtubule sliding along the bud cortex and consequently the movement of the mitotic spindle to the bud neck.


ensembl_gene_id: Q5A7R7
symbol: IFF11
gene_biotype: protein_coding
description:
  Cell wall protein IFF11; GPI-anchored cell wall protein involved in cell wall organization, hyphal growth, as well as in host-fungal interaction and virulence; Belongs to the HYR1/IFF family.


ensembl_gene_id: Q5A7S7
symbol: FKH2
gene_biotype: protein_coding
description:
  Fork-head transcriptional regulator 2; Transcription factor required for the morphogenesis of true hyphal as well as yeast cells. Contributes to virulence.


ensembl_gene_id: Q5A845
symbol: CaO19.3283
gene_biotype: protein_coding
description:
  3-oxoacyl-[acyl-carrier-protein] reductase (NADPH); Belongs to the short-chain dehydrogenases/reductases (SDR) family.


ensembl_gene_id: Q5A846
symbol: BMT3
gene_biotype: protein_coding
description:
  Beta-mannosyltransferase 3; Beta-mannosyltransferase involved in cell wall biosynthesis. Required for addition of the second beta-mannose residue to acid-stable fraction of cell wall phosphopeptidomannan, and in elongation of beta- mannose chains on the phosphopeptidomannan acid-labile fraction. Belongs to the BMT family.


ensembl_gene_id: Q5A847
symbol: JHD1
gene_biotype: protein_coding
description:
  JmjC domain-containing histone demethylation protein 1; Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code.


ensembl_gene_id: Q5A849
symbol: HYR4
gene_biotype: protein_coding
description:
  Hyphally regulated cell wall protein 4; GPI-anchored cell wall protein involved in cell wall organization, hyphal growth, as well as in host-fungal interaction and virulence; Belongs to the HYR1/IFF family.


ensembl_gene_id: Q5A850
symbol: GSY1
gene_biotype: protein_coding
description:
  Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan.


ensembl_gene_id: Q5A860
symbol: TMA19
gene_biotype: protein_coding
description:
  Translationally-controlled tumor protein homolog; Involved in protein synthesis. Involved in microtubule stabilization (By similarity); Belongs to the TCTP family.


ensembl_gene_id: Q5A861
symbol: SWF1
gene_biotype: protein_coding
description:
  Palmitoyltransferase SWF1; Palmitoyltransferase that targets several endosomal SNAREs. Palmitoylates the SNAREs at cysteine residues close to the cytoplasmic end of their transmembrane domain. May have a role in the cellular quality control of transmembrane domain-containing proteins (By similarity); Belongs to the DHHC palmitoyltransferase family. SWF1 subfamily.


ensembl_gene_id: Q5A869
symbol: SEC11
gene_biotype: protein_coding
description:
  Signal peptidase complex catalytic subunit SEC11; Catalytic component of the signal peptidase complex (SPC), which catalyzes the cleavage of N-terminal signal sequences of proteins targeted to the endoplasmic reticulum. Signal peptide cleavage occurs during the translocation (cotranslationally or post-translationally) through the translocon pore into the endoplasmic reticulum (By similarity).


ensembl_gene_id: Q5A872
symbol: SLN1
gene_biotype: protein_coding
description:
  Histidine protein kinase SLN1; Histidine kinase involved in a two-component signaling pathway that regulates cell wall mannan biosynthesis. Part of the bifurcated SLN1-YPD1-SKN7/SSK1 two-component regulatory system, which controls activity of the HOG1 pathway and gene expression in response to oxidative stress and probably also to changes in the osmolarity of the extracellular environment. Plays a role in the regulation of alternative oxidase (AOX) gene family expression. Required for hyphal formation and virulence.


ensembl_gene_id: Q5A884
symbol: COX23
gene_biotype: protein_coding
description:
  Cytochrome c oxidase-assembly factor COX23, mitochondrial; Required for the assembly of cytochrome c oxidase. Belongs to the COX23 family.


ensembl_gene_id: Q5A885
symbol: SRP54
gene_biotype: protein_coding
description:
  Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). Belongs to the GTP-binding SRP family. SRP54 subfamily.


ensembl_gene_id: Q5A886
symbol: CaO19.3242
gene_biotype: protein_coding
description:
  Transcription initiation factor TFIID subunit 10; Functions as a component of the DNA-binding general transcription factor complex TFIID and the transcription regulatory histone acetylation (HAT) complexes SAGA and SLIK. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modificati [...]


ensembl_gene_id: Q5A893
symbol: CAP01
gene_biotype: protein_coding
description:
  F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).


ensembl_gene_id: Q5A895
symbol: HSE1
gene_biotype: protein_coding
description:
  Class E vacuolar protein-sorting machinery protein HSE1; Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB).


ensembl_gene_id: Q5A8A2
symbol: NPC2
gene_biotype: protein_coding
description:
  Phosphatidylglycerol/phosphatidylinositol transfer protein; Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol; Belongs to the NPC2 family.


ensembl_gene_id: Q5A8H7
symbol: SWC5
gene_biotype: protein_coding
description:
  SWR1-complex protein 5; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability (By similarity).


ensembl_gene_id: Q5A8I6
symbol: PGA61
gene_biotype: protein_coding
description:
  Probable cell wall protein PGA61; Probable GPI-anchored cell wall protein that may be involved in cell wall organization, hyphal growth, as well as in virulence.


ensembl_gene_id: Q5A8I8
symbol: IHD1
gene_biotype: protein_coding
description:
  Induced during hyphae development protein 1; GPI-anchored cell wall protein that may be involved in cell wall organization, hyphal growth, as well as in virulence. Belongs to the IHD1 family.


ensembl_gene_id: Q5A8J5
symbol: HGT10
gene_biotype: protein_coding
description:
  Glucose-inactivated glycerol proton symporter; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.


ensembl_gene_id: Q5A8K2
symbol: ALA1
gene_biotype: protein_coding
description:
  Alanine--tRNA ligase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.


ensembl_gene_id: Q5A8N2
symbol: SAP4
gene_biotype: protein_coding
description:
  Candidapepsin-4; Secreted aspartic peptidases (SAPs) are a group of ten acidic hydrolases considered as key virulence factors. These enzymes supply the fungus with nutrient amino acids as well as are able to degrade the selected host's proteins involved in the immune defense. Activates host systemic immunity. During infection, plays an important role in penetration into deeper tissues and interaction with host defense. Moreover, acts toward human hemoglobin though limited proteolysis to generate a variety of antimicrobial hemocidins, enabling to compete with the other microorganisms of [...]


ensembl_gene_id: Q5A8T4
symbol: ALS1
gene_biotype: protein_coding
description:
  Agglutinin-like protein 1; Major cell surface adhesion protein which mediates both yeast-to-host tissue adherence and yeast aggregation. Acts as a downstream effector of the EFG1 regulatory pathway. Required for rapamycin-induced aggregation of C.albicans. Binds glycans and mediates adherence to endothelial and epithelial cells, thereby playing an important role in the pathogenesis of C.albicans infections.


ensembl_gene_id: Q5A8T7
symbol: ALS5
gene_biotype: protein_coding
description:
  Agglutinin-like protein 5; Cell surface adhesion protein which mediates both yeast-to- host tissue adherence and yeast aggregation. Plays an important role in the pathogenesis of C.albicans infections. Forms amyloid structures, essential for cell-cell association and cell-substrate adhesion to polystyrene. Belongs to the ALS family.


ensembl_gene_id: Q5A8W9
symbol: CCM1
gene_biotype: protein_coding
description:
  Mitochondrial group I intron splicing factor CCM1; RNA-binding protein involved in the specific removal of group I introns in mitochondrial encoded transcripts. Maintains the stability of the small subunit mitochondrial 15S rRNA and thus the expression of the mitochondrial genome (By similarity); Belongs to the CCM1 family.


ensembl_gene_id: Q5A8X6
symbol: LSC1
gene_biotype: protein_coding
description:
  Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.


ensembl_gene_id: Q5A8X7
symbol: FYV4
gene_biotype: protein_coding
description:
  Protein FYV4, mitochondrial; Involved in telomere length regulation; Belongs to the mitochondrion-specific ribosomal protein mS41 family.


ensembl_gene_id: Q5A8X9
symbol: ISN1
gene_biotype: protein_coding
description:
  IMP-specific 5'-nucleotidase 1; IMP-specific 5'-nucleotidase involved in IMP (inositol monophosphate) degradation; Belongs to the ISN1 family.


ensembl_gene_id: Q5A8Z0
symbol: VPS17
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 17; Plays a role in vesicular protein sorting. Belongs to the VPS17 family.


ensembl_gene_id: Q5A917
symbol: SRB6
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 22; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).


ensembl_gene_id: Q5A931
symbol: PPM2
gene_biotype: protein_coding
description:
  tRNA wybutosine-synthesizing protein 4; Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. May methylate the carboxyl group of leucine residues to form alpha-leucine ester residues (By similarity); Belongs to the methyltransferase superfamily. LCMT family.


ensembl_gene_id: Q5A940
symbol: MBF1
gene_biotype: protein_coding
description:
  Multiprotein-bridging factor 1; Transcriptional coactivator that stimulates transcriptional activity by bridging regulatory proteins and TBP, thereby recruiting TBP to promoters occupied by DNA-binding regulators.


ensembl_gene_id: Q5A943
symbol: HMT1
gene_biotype: protein_coding
description:
  Protein-arginine omega-N methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.


ensembl_gene_id: Q5A950
symbol: ATG26
gene_biotype: protein_coding
description:
  Sterol 3-beta-glucosyltransferase; Probable sterol 3-beta-glucosyltransferase that is not involved in cytoplasm to vacuole transport (Cvt), pexophagy or nonselective autophagy (By similarity).


ensembl_gene_id: Q5A960
symbol: HDA1
gene_biotype: protein_coding
description:
  Histone deacetylase HDA1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates the YNG2 subunit of NuA4 histone acetyltransferase (HAT) module, leading to the reduction of YNG2 and NuA4 HAT at the promoters of hypha-specific genes. Plays a key role in the regulation o [...]


ensembl_gene_id: Q5A961
symbol: PRK1
gene_biotype: protein_coding
description:
  Actin-regulating kinase PRK1; Protein kinase involved in regulation of actin cytoskeleton organization and endocytosis. Phosphorylates the endocytic protein SLA1. The CDC28-CLN3 complex phosphorylation of SLA1 enhances its further phosphorylation by PRK1, weakening SLA1 association with PAN1, an activator of the actin-nucleating ARP2/3 complex. Plays a role in cell wall regulation and required for oxidative stress survival.


ensembl_gene_id: Q5A970
symbol: MRS2
gene_biotype: protein_coding
description:
  Mitochondrial inner membrane magnesium transporter MRS2; High-conductance magnesium-selective channel that mediates the influx of magnesium into the mitochondrial matrix. Essential for the splicing of mRNA group II introns in mitochondria by affecting mitochondrial magnesium concentrations, which are critical for group II intron splicing. It also suppresses a variety of mitochondrial intron mutations and its absence may disturb the assembly of mitochondrial membrane complexes.


ensembl_gene_id: Q5A975
symbol: CaO19.2591
gene_biotype: protein_coding
description:
  Adenosylmethionine-8-amino-7-oxononanoate transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.


ensembl_gene_id: Q5A985
symbol: HST2
gene_biotype: protein_coding
description:
  NAD-dependent protein deacetylase HST2; NAD-dependent histone deacetylase that is involved in nuclear silencing events. Derepresses subtelomeric silencing and increases repression in nucleolar (rDNA) silencing. Its function is negatively regulated by active nuclear export (By similarity); Belongs to the sirtuin family. Class I subfamily.


ensembl_gene_id: Q5A9E1
symbol: MGE1
gene_biotype: protein_coding
description:
  GrpE protein homolog; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the GrpE family.


ensembl_gene_id: Q5A9Z1
symbol: PET112
gene_biotype: protein_coding
description:
  Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).


ensembl_gene_id: Q5A9Z6
symbol: FAL1
gene_biotype: protein_coding
description:
  ATP-dependent RNA helicase FAL1; ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA (By similarity). Belongs to the DEAD box helicase family. DDX48/FAL1 subfamily.


ensembl_gene_id: Q5AA09
symbol: PGA26
gene_biotype: protein_coding
description:
  Predicted GPI-anchored protein 26; GPI-anchored protein involved in proper cell wall integrity. Does not seem to be directly involved in the synthesis of the cell wall. Required for normal virulence in a mouse model of disseminated candidiasis.


ensembl_gene_id: Q5AA40
symbol: CHS7
gene_biotype: protein_coding
description:
  Chitin synthase export chaperone; Chaperone required for the export of the chitin synthase CHS3 from the endoplasmic reticulum.


ensembl_gene_id: Q5AA47
symbol: ARC35
gene_biotype: protein_coding
description:
  Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.


ensembl_gene_id: Q5AA50
symbol: NPL4
gene_biotype: protein_coding
description:
  Nuclear protein localization protein 4; Involved in the import of nuclear-targeted proteins into the nucleus and the export of poly(A) RNA out of the nucleus. Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway (By similarity); Belongs to the NPL4 family.


ensembl_gene_id: Q5AAF4
symbol: BNR1
gene_biotype: protein_coding
description:
  Formin BNR1; May organize microtubules by mediating spindle positioning and movement in the budding process. Required for cytokinesis and the maintenance of polarized hyphal growth; Belongs to the formin homology family. BNI1 subfamily.


ensembl_gene_id: Q5AAG1
symbol: EPL1
gene_biotype: protein_coding
description:
  Enhancer of polycomb-like protein 1; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in gene silencing by neighboring heterochromatin, blockage of the silencing spreading along the chromosome, and required for cell cycle progression through G2/M (By similarity).


ensembl_gene_id: Q5AAG6
symbol: MKC1
gene_biotype: protein_coding
description:
  Mitogen-activated protein kinase MKC1; Serine/threonine protein kinase component of the cell integrity pathway, a signal transduction pathway that plays a role in yeast cell morphogenesis and cell growth. Participates in cell wall construction, azole resistance, and host interaction. Required for the signaling for invasive filamentous growth and biofilm formation, and plays a crucial role in virulence.


ensembl_gene_id: Q5AAH2
symbol: CHT1
gene_biotype: protein_coding
description:
  Chitinase 1; Chitinase involved in the remodeling of chitin in the fungal cell wall. Plays a role in cell separation.


ensembl_gene_id: Q5AAI8
symbol: NAP1
gene_biotype: protein_coding
description:
  Nucleosome assembly protein 1; Acidic protein, which assembles histones into an octamer (By similarity). Involved in the regulation of the localization and the function of the septins during mitosis.


ensembl_gene_id: Q5AAJ7
symbol: SWC4
gene_biotype: protein_coding
description:
  SWR1-complex protein 4; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity).


ensembl_gene_id: Q5AAJ8
symbol: RTT109
gene_biotype: protein_coding
description:
  Histone acetyltransferase RTT109; Required for acetylation of 'Lys-56' of histone H3 (H3K56ac) which occurs in S phase and disappears during G(2)/M phase of the cell cycle and is involved in transcription DNA repair process. Required for efficient pathogenesis in mice suggesting that efficient DNA repair is required for pathogenesis. Plays an important role in the regulation of white-opaque genotoxin induced-switching; Belongs to the RTT109 family.


ensembl_gene_id: Q5AAL9
symbol: IFF4
gene_biotype: protein_coding
description:
  Cell wall protein IFF4; GPI-anchored cell wall protein involved in cell wall organization, hyphal growth, as well as in host-fungal interaction and virulence. Plays a role in adherence to plastic and to host epithelial cells. Promotes the tissue fungal burden during murine vaginal candidiasis. Increases also susceptibility to neutrophil-mediated killing. Furthermore, contributes to the severity of hematogenously disseminated candidiasis in normal mice, but not in neutropenic mice.


ensembl_gene_id: Q5AAR0
symbol: IWS1
gene_biotype: protein_coding
description:
  Transcription factor IWS1; Transcription factor involved in RNA polymerase II transcription regulation. May function in both SPT15/TBP post- recruitment and recruitment steps of transcription (By similarity). Belongs to the IWS1 family.


ensembl_gene_id: Q5AAT0
symbol: RAI1
gene_biotype: protein_coding
description:
  Decapping nuclease RAI1; Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping and pyrophosphohydrolase activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA. Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5' end triphosphate to release pyrophosphates (By similarity). Belongs to the DXO/Dom3Z family.


ensembl_gene_id: Q5AAU3
symbol: PGA63
gene_biotype: protein_coding
description:
  Protein transport protein SEC31; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity).


ensembl_gene_id: Q5AAU5
symbol: ATC1
gene_biotype: protein_coding
description:
  Cell wall acid trehalase ATC1; Cell wall acid trehalase that catalyzes hydrolysis of the disaccharide trehalose and required for growth on trehalose as carbon source. Plays a role in dimorphic conversion and virulence.


ensembl_gene_id: Q5AAV3
symbol: MEF2
gene_biotype: protein_coding
description:
  Ribosome-releasing factor 2, mitochondrial; Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Not involved in the GTP-dependent ribosomal translocation step during translation elongation; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.


ensembl_gene_id: Q5AAW3
symbol: DHH1
gene_biotype: protein_coding
description:
  ATP-dependent RNA helicase DHH1; ATP-dependent RNA helicase involved in mRNA turnover, and more specifically in mRNA decapping. Is involved in G1/S DNA-damage checkpoint recovery, probably through the regulation of the translational status of a subset of mRNAs. May also have a role in translation and mRNA nuclear export (By similarity); Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.


ensembl_gene_id: Q5AB15
symbol: IPI3
gene_biotype: protein_coding
description:
  Pre-rRNA-processing protein IPI3; Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.


ensembl_gene_id: Q5AB48
symbol: RBT4
gene_biotype: protein_coding
description:
  Secreted protein RBT4; Secreted protein that acts as a virulence factor during infections such as in posttraumatic corneal infections. Acts as an important antigen in patients with systemic candidiasis and plays a role in the protection against phagocyte attack.


ensembl_gene_id: Q5AB49
symbol: CaO19.6200
gene_biotype: protein_coding
description:
  Probable pathogenesis-related protein CaO19.6200; Secreted protein that acts as a virulence factor during infections; Belongs to the CRISP family.


ensembl_gene_id: Q5AB93
symbol: PNS1
gene_biotype: protein_coding
description:
  Protein PNS1; Probably involved in transport through the plasma membrane. Belongs to the CTL (choline transporter-like) family.


ensembl_gene_id: Q5ABA6
symbol: ATG18
gene_biotype: protein_coding
description:
  Autophagy-related protein 18; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation- induced autophagy. Involved in correct ATG9 trafficking to the pre- autophagosomal structure. Might also be involved in premeiotic DNA replication (By similarity).


ensembl_gene_id: Q5ABB2
symbol: GLO1
gene_biotype: protein_coding
description:
  Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.


ensembl_gene_id: Q5ABB3
symbol: CaO19.6057
gene_biotype: protein_coding
description:
  3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate.


ensembl_gene_id: Q5ABC3
symbol: TUF1
gene_biotype: protein_coding
description:
  Elongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis.


ensembl_gene_id: Q5ABC5
symbol: PSD1
gene_biotype: protein_coding
description:
  Phosphatidylserine decarboxylase proenzyme 1, mitochondrial; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine (By similarity). Important for virulence.


ensembl_gene_id: Q5ABC6
symbol: MOB2
gene_biotype: protein_coding
description:
  CBK1 kinase activator protein MOB2; Functions as an activator subunit for the CBK1 protein kinase. Part of the regulation of ACE2 activity and cellular morphogenesis (RAM) signaling network. The RAM network is critically required for hyphal growth as well as normal vegetative growth, and for polarization of lipid rafts and the actin cytoskeleton. It play an essential role in biofilm formation. The RAM network plays also a role in serum- and antifungal azoles-induced activation of ergosterol biosynthesis genes, especially those involved in the late steps of ergosterol biosynthesis.


ensembl_gene_id: Q5ABD0
symbol: SNF7
gene_biotype: protein_coding
description:
  Vacuolar-sorting protein SNF7; Required for the sorting and concentration of proteins resulting in the entry of these proteins into the invaginating vesicles of the multivesicular body (MVB). Also required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH.


ensembl_gene_id: Q5ABD9
symbol: VPS27
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 27; Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.


ensembl_gene_id: Q5ABE2
symbol: HGC1
gene_biotype: protein_coding
description:
  Hypha-specific G1 cyclin-related protein 1; Hypha-specific G1 cyclin-related protein involved in regulation of morphogenesis and opaque cells filamentous growth, and required for both conventional and pheromone-stimulated biofilm formation. Required to maintain hyphal tip localization of actin and SPA2. Regulates the CDC28 kinase during hyphal growth. The CDC28-HGC1 complex phosphorylates and prevents RGA2 from localizing to hyphal tips, leading to localized CDC42 activation for hyphal extension. The CDC28-HGC1 complex also phosphorylates SEC2 and maintains CDC11 phosphorylation throug [...]


ensembl_gene_id: Q5ABE5
symbol: ALG13
gene_biotype: protein_coding
description:
  UDP-N-acetylglucosamine transferase subunit ALG13; Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway (By similarity). Belongs to the glycosyltransferase 28 family.


ensembl_gene_id: Q5ABG1
symbol: SET1
gene_biotype: protein_coding
description:
  Histone-lysine N-methyltransferase, H3 lysine-4 specific; Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance, transcription elongation regulation and pathogenesis of invasive candidiasis; Belongs to the class V-like SAM-binding methyltransferase superfamily.


ensembl_gene_id: Q5ABP8
symbol: ROT1
gene_biotype: protein_coding
description:
  Protein ROT1; Required for normal levels of the cell wall 1,6-beta-glucan. Involved in a protein folding machinery chaperoning proteins acting in various physiological processes including cell wall synthesis and lysis of autophagic bodies (By similarity); Belongs to the ROT1 family.


ensembl_gene_id: Q5ABQ7
symbol: ATG3
gene_biotype: protein_coding
description:
  Autophagy-related protein 3; E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt) and autophagy. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C- terminal Gly of ATG8. The ATG12-ATG5 conjugate plays a role of an E3 and promotes the transfer of [...]


ensembl_gene_id: Q5ABR2
symbol: GEM1
gene_biotype: protein_coding
description:
  Mitochondrial Rho GTPase 1; Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution.


ensembl_gene_id: Q5ABS1
symbol: QCR7
gene_biotype: protein_coding
description:
  Cytochrome b-c1 complex subunit 7; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain; Belongs to the UQCRB/QCR7 family.


ensembl_gene_id: Q5ABT8
symbol: BMT4
gene_biotype: protein_coding
description:
  Beta-mannosyltransferase 4; Beta-mannosyltransferase involved in cell wall biosynthesis. Required for the elongation of beta-mannose chains on the acid-labile fraction of cell wall phosphopeptidomannan. Belongs to the BMT family.


ensembl_gene_id: Q5ABU0
symbol: ARG3
gene_biotype: protein_coding
description:
  Ornithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily.


ensembl_gene_id: Q5ABU7
symbol: MDR1
gene_biotype: protein_coding
description:
  Multidrug resistance protein 1; Plasma membrane multidrug efflux pump that confers resistance to numerous chemicals including azoles such as fluconazole, voriconazole, and benztriazoles, as well as to benomyl, cycloheximide, methotrexate, 4-nitroquinoline-N-oxide, sulfometuron methyl, cerulenin, and brefeldin A. Belongs to the major facilitator superfamily. CAR1 family.


ensembl_gene_id: Q5ABU8
symbol: BMT6
gene_biotype: protein_coding
description:
  Beta-mannosyltransferase 6; Beta-mannosyltransferase involved in cell wall biosynthesis. Required for beta-1,2-mannose transfer on phospholipomannan. Required for proinflammatory response in macrophages through phospholipomannan- induced TNF-alpha production; Belongs to the BMT family.


ensembl_gene_id: Q5ABV6
symbol: SHE3
gene_biotype: protein_coding
description:
  SWI5-dependent HO expression protein 3; RNA-binding protein that binds specific mRNAs including the ASH1 mRNA, coding for a repressor of the HO endonuclease. Part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud and in the daughter cell. Required for the delivery of cortical endoplasmic reticulum into the emerging bud (By similarity); Belongs to the SHE3 family.


ensembl_gene_id: Q5ABX0
symbol: TEL1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase TEL1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability (By similarity).


ensembl_gene_id: Q5ABZ2
symbol: RBF1
gene_biotype: protein_coding
description:
  Transcription factor RBF1; Transcriptional activator that binds to the RPG box and to telomeres. Involved in the regulation of the transition between yeast and filamentous forms and plays a role in virulence. Induces expression of HWP1, a major hyphal cell protein and virulence factor. Belongs to the RBF1 family.


ensembl_gene_id: Q5AC00
symbol: MRT4
gene_biotype: protein_coding
description:
  Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.


ensembl_gene_id: Q5AC08
symbol: SAP6
gene_biotype: protein_coding
description:
  Candidapepsin-6; Secreted aspartic peptidases (SAPs) are a group of ten acidic hydrolases considered as key virulence factors. These enzymes supply the fungus with nutrient amino acids as well as are able to degrade the selected host's proteins involved in the immune defense. During infection, plays an important role in penetration into deeper tissues and interaction with host defense. Activates host systemic immunity and induces host inflammatory cytokine production in a proteolytic activity-independent way. Contributes to corneal pathogenicity. Moreover, acts toward human hemoglobin  [...]


ensembl_gene_id: Q5AC48
symbol: ARP4
gene_biotype: protein_coding
description:
  Actin-related protein 4; Chromatin interaction component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Is required for NuA4 complex integrity. Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the INO80 complex which remodels chromatin by shifting nucleosomes [...]


ensembl_gene_id: Q5ACH7
symbol: COX16
gene_biotype: protein_coding
description:
  Cytochrome c oxidase assembly protein COX16, mitochondrial; Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. May participate in merging the COX1 and COX2 assembly lines. Belongs to the COX16 family.


ensembl_gene_id: Q5ACI8
symbol: CPR6
gene_biotype: protein_coding
description:
  Peptidyl-prolyl cis-trans isomerase D; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).


ensembl_gene_id: Q5ACL4
symbol: RTC1
gene_biotype: protein_coding
description:
  Restriction of telomere capping protein 1; May be involved in a process influencing telomere capping. Belongs to the WD repeat RTC1 family.


ensembl_gene_id: Q5ACL7
symbol: PGA1
gene_biotype: protein_coding
description:
  Predicted GPI-anchored protein 1; Plays a role in cell wall stability and rigidity. Required for normal adhesion to host cells and for adherence during biofilm formation. Necessary for proper oxidative stress response.


ensembl_gene_id: Q5ACM4
symbol: PNO1
gene_biotype: protein_coding
description:
  Pre-rRNA-processing protein PNO1; Required for small ribosomal subunit (SSU) synthesis. Has a role in the processing of early nucleolar and late cytoplasmic pre-RNA species (By similarity).


ensembl_gene_id: Q5ACM9
symbol: HCR1
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 3 subunit J; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.


ensembl_gene_id: Q5ACR4
symbol: YOS9
gene_biotype: protein_coding
description:
  Protein OS-9 homolog; Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation (By similarity).


ensembl_gene_id: Q5ACU3
symbol: PMT5
gene_biotype: protein_coding
description:
  Dolichyl-phosphate-mannose--protein mannosyltransferase 5; Protein mannosyltransferase (PMT) involved in hyphal morphogenesis and drug sensitivity. Transfers mannose from Dol-P- mannose to Ser or Thr residues on proteins. PMT1, PMT2 and PMT4 account for most of the protein-O-glycosylation activity, while PMT5 and PMT6 may specifically modulate a much narrower spectrum of target proteins. Required for biofilm formation.


ensembl_gene_id: Q5ACU4
symbol: SRB7
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).


ensembl_gene_id: Q5ACU6
symbol: RRP3
gene_biotype: protein_coding
description:
  ATP-dependent rRNA helicase RRP3; ATP-dependent rRNA helicase required for pre-ribosomal RNA processing. Involved in the maturation of the 35S-pre-rRNA and to its cleavage to mature 18S rRNA.


ensembl_gene_id: Q5ACV3
symbol: CaO19.2114
gene_biotype: protein_coding
description:
  Uricase; Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin. Belongs to the uricase family.


ensembl_gene_id: Q5ACV9
symbol: SOD6
gene_biotype: protein_coding
description:
  Cell surface superoxide dismutase [Cu-Zn] 6; Superoxide dismutases serve to convert damaging superoxide radicals, a key form of ROS, to less damaging hydrogen peroxide that can be converted into water by catalase action. May be involved protection against extracellular stress.


ensembl_gene_id: Q5ACW6
symbol: GET1
gene_biotype: protein_coding
description:
  Golgi to ER traffic protein 1; Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET2, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP- dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER.


ensembl_gene_id: Q5ACW8
symbol: HIR1
gene_biotype: protein_coding
description:
  Protein HIR1; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family.


ensembl_gene_id: Q5ACX1
symbol: RAD5
gene_biotype: protein_coding
description:
  DNA repair protein RAD5; Probable helicase, member of the UBC2/RAD6 epistasis group. Functions with DNA repair protein RAD18 in error-free postreplication DNA repair. Involved in the maintenance of wild-type rates of instability of simple repetitive sequences such as poly(GT) repeats. Seems to be involved in maintaining a balance which acts in favor of error-prone non-homologous joining during DNA double-strand breaks repairs (By similarity).


ensembl_gene_id: Q5ACX4
symbol: RFA1
gene_biotype: protein_coding
description:
  Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.


ensembl_gene_id: Q5ACZ2
symbol: DFG5
gene_biotype: protein_coding
description:
  Mannan endo-1,6-alpha-mannosidase DFG5; Required for normal synthesis of the cell wall and alkaline pH-induced hypha formation.


ensembl_gene_id: Q5AD05
symbol: SOD4
gene_biotype: protein_coding
description:
  Cell surface superoxide dismutase [Cu-Zn] 4; Superoxide dismutases serve to convert damaging superoxide radicals, a key form of ROS, to less damaging hydrogen peroxide that can be converted into water by catalase action. Degrades host-derived reactive oxygen species to escape innate immune surveillance. Involved in the occurrence of miconazole-tolerant persisters in biofilms. Persisters are cells that survive high doses of an antimicrobial agent.


ensembl_gene_id: Q5AD07
symbol: SOD5
gene_biotype: protein_coding
description:
  Cell surface Cu-only superoxide dismutase 5; Superoxide dismutases serve to convert damaging superoxide radicals, a key form of ROS, to less damaging hydrogen peroxide that can be converted into water by catalase action. Degrades host-derived reactive oxygen species to escape innate immune surveillance. Involved in the occurrence of miconazole-tolerant persisters in biofilms. Persisters are cells that survive high doses of an antimicrobial agent. The unusual attributes of SOD5-like fungal proteins, including the absence of zinc and an open active site that readily captures extracellula [...]


ensembl_gene_id: Q5AD13
symbol: FGR15
gene_biotype: protein_coding
description:
  Filamentous growth regulator 15; Probable transcription factor involved in the regulation of filamentous growth.


ensembl_gene_id: Q5AD27
symbol: TAH18
gene_biotype: protein_coding
description:
  NADPH-dependent diflavin oxidoreductase 1; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe-S cluster of DRE2. Positively controls H(2)O(2)-induced cell death; In the N-terminal section; belongs to the flavodoxin family.


ensembl_gene_id: Q5AD34
symbol: PGA19
gene_biotype: protein_coding
description:
  Predicted GPI-anchored protein 19; Predicted GPI-anchored protein which may have a role during host infection.


ensembl_gene_id: Q5AD47
symbol: HGT6
gene_biotype: protein_coding
description:
  Hexose transporter; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.


ensembl_gene_id: Q5AD49
symbol: JJJ3
gene_biotype: protein_coding
description:
  Diphthamide biosynthesis protein 4; Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2 (By similarity). Belongs to the DPH4 family.


ensembl_gene_id: Q5AD56
symbol: NOT3
gene_biotype: protein_coding
description:
  General negative regulator of transcription subunit 3; Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery (By similarity). Required for yeast cell adherence to silicone substrate, but nor required [...]


ensembl_gene_id: Q5AD59
symbol: MRI1
gene_biotype: protein_coding
description:
  Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.


ensembl_gene_id: Q5AD67
symbol: CHL1
gene_biotype: protein_coding
description:
  ATP-dependent DNA helicase CHL1; ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G(2)/M (By similarity). May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres (By similarity). Has a specific role in chromosome segregation during meiosis II (By similarity).


ensembl_gene_id: Q5AD72
symbol: MNN24
gene_biotype: protein_coding
description:
  Alpha-1,2-mannosyltransferase MNN24; Alpha-1,2-mannosyltransferase required for cell wall integrity. Responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides. Addition of alpha-1,2-mannose is required for stabilization of the alpha-1,6-mannose backbone and hence regulates mannan fibril length; and is important for both immune recognition and virulence.


ensembl_gene_id: Q5AD77
symbol: SNX4
gene_biotype: protein_coding
description:
  Sorting nexin-4; Required for cytoplasm to vacuole transport (Cvt) and pexophagy. Involved in the fusion between the pexophagosome and the vacuole. Also involved in the separation or division of vacuoles throughout the entire life cycle of the cells (By similarity).


ensembl_gene_id: Q5AD78
symbol: DCW1
gene_biotype: protein_coding
description:
  Mannan endo-1,6-alpha-mannosidase DCW1; Probable mannosidase required for normal synthesis of the cell wall; Belongs to the glycosyl hydrolase 76 family.


ensembl_gene_id: Q5ADL0
symbol: PRP5
gene_biotype: protein_coding
description:
  Pre-mRNA-processing ATP-dependent RNA helicase PRP5; ATP-dependent RNA helicase involved spliceosome assembly and in nuclear splicing. Catalyzes an ATP-dependent conformational change of U2 snRNP. Bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA (By similarity); Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily.


ensembl_gene_id: Q5ADL8
symbol: TRY6
gene_biotype: protein_coding
description:
  Transcriptional regulator of yeast form adherence 6; Transcription factor required for yeast cell adherence to silicone substrate.


ensembl_gene_id: Q5ADL9
symbol: DCN1
gene_biotype: protein_coding
description:
  Defective in cullin neddylation protein 1; May contribute to neddylation of cullin components of SCF- type E3 ubiquitin ligase complexes. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity (By similarity).


ensembl_gene_id: Q5ADM9
symbol: PMT2
gene_biotype: protein_coding
description:
  Dolichyl-phosphate-mannose--protein mannosyltransferase 2; Protein mannosyltransferase (PMT) involved in hyphal growth and drug sensitivity. Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. PMT1, PMT2 and PMT4 account for most of the protein-O-glycosylation activity, while PMT5 and PMT6 may specifically modulate a much narrower spectrum of target proteins. Essential protein that plays an important role in virulence. Belongs to the glycosyltransferase 39 family.


ensembl_gene_id: Q5ADN7
symbol: CaO19.6804
gene_biotype: protein_coding
description:
  Signal recognition particle subunit SRP68; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane; Belongs to the SRP68 family.


ensembl_gene_id: Q5ADN8
symbol: HUT1
gene_biotype: protein_coding
description:
  UDP-galactose transporter homolog 1; May be involved in specific transport of UDP-Gal from the cytosol to the Golgi lumen. Involved in the maintenance of optimal conditions for the folding of secretory pathway proteins in the endoplasmic reticulum (By similarity); Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.


ensembl_gene_id: Q5ADN9
symbol: PFA3
gene_biotype: protein_coding
description:
  Palmitoyltransferase PFA3; Palmitoyltransferase specific for VAC8. Palmitoylates VAC8 at one or more of its N-terminal cysteine residues, which is required for its proper membrane localization (By similarity).


ensembl_gene_id: Q5ADP6
symbol: SUS1
gene_biotype: protein_coding
description:
  Transcription and mRNA export factor SUS1; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex required for deubiquitination of  [...]


ensembl_gene_id: Q5ADP9
symbol: RRD1
gene_biotype: protein_coding
description:
  Serine/threonine-protein phosphatase 2A activator 1; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A- phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex (By similarity).


ensembl_gene_id: Q5ADQ0
symbol: HHT3
gene_biotype: protein_coding
description:
  Histone H3.3; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).


ensembl_gene_id: Q5ADQ7
symbol: PGA32
gene_biotype: protein_coding
description:
  Probable GPI-anchored adhesin-like protein PGA32; Putative adhesin which is involved in cell adhesion and virulence.


ensembl_gene_id: Q5ADQ8
symbol: CaO19.6783
gene_biotype: protein_coding
description:
  Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.


ensembl_gene_id: Q5ADQ9
symbol: BMT1
gene_biotype: protein_coding
description:
  Beta-mannosyltransferase 1; Beta-mannosyltransferase involved in cell wall biosynthesis. Required for addition of the first beta-mannose residue to acid-stable fraction of cell wall phosphopeptidomannan. Plays a key role in reducing host inflammatory response.


ensembl_gene_id: Q5ADR6
symbol: GCD2
gene_biotype: protein_coding
description:
  Translation initiation factor eIF2B subunit delta; Belongs to the eIF-2B alpha/beta/delta subunits family.


ensembl_gene_id: Q5ADT1
symbol: MDS3
gene_biotype: protein_coding
description:
  Negative regulator of sporulation MDS3; Negatively regulates early sporulation-specific genes (By similarity). TOR signaling pathway component that contributes to morphogenesis as a regulator of this key morphogenetic pathway. Required for growth and hyphal formation at pH 9, for full virulence in a mouse model of systemic infection and for biofilm formation. Involved in chlamydospore formation, distinctive morphological feature of the fungal pathogen C.albicans that can be induced to form in oxygen- limited environments and has been reported in clinical specimens.


ensembl_gene_id: Q5ADT9
symbol: RSM10
gene_biotype: protein_coding
description:
  37S ribosomal protein S10, mitochondrial; Involved in mitochondrial genome encoded proteins translation. Involved in the binding of tRNA to the ribosomes (By similarity).


ensembl_gene_id: Q5ADU0
symbol: TRM7
gene_biotype: protein_coding
description:
  Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.


ensembl_gene_id: Q5ADU3
symbol: CaO19.6748
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 3 subunit H; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.


ensembl_gene_id: Q5ADU9
symbol: CaO19.6742
gene_biotype: protein_coding
description:
  RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.


ensembl_gene_id: Q5ADV5
symbol: GEP3
gene_biotype: protein_coding
description:
  Genetic interactor of prohibitins 3, mitochondrial; May be involved in the mitochondrial lipid metabolism. Belongs to the TRAFAC class YlqF/YawG GTPase family. GEP3 subfamily.


ensembl_gene_id: Q5ADW3
symbol: TIP120
gene_biotype: protein_coding
description:
  Cullin-associated NEDD8-dissociated protein 1; Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate- recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor (Probable); Belongs to the CAND family.


ensembl_gene_id: Q5ADX2
symbol: HIR3
gene_biotype: protein_coding
description:
  Histone transcription regulator 3 homolog; Has a role in a nucleosome assembly pathway that is required for the integrity of heterochromatin and proper chromosome segregation. Belongs to the HIR3 family.


ensembl_gene_id: Q5ADX5
symbol: ABD1
gene_biotype: protein_coding
description:
  mRNA cap guanine-N7 methyltransferase; Responsible for methylating the 5'-cap structure of mRNAs. Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.


ensembl_gene_id: Q5AEC6
symbol: BMT7
gene_biotype: protein_coding
description:
  Beta-mannosyltransferase 7; Beta-mannosyltransferase involved in cell wall biosynthesis through beta-1,2-mannosylation of cell wall phosphopeptidomannan.


ensembl_gene_id: Q5AED6
symbol: CLF1
gene_biotype: protein_coding
description:
  Pre-mRNA-splicing factor CLF1; Involved in pre-mRNA splicing and cell cycle progression. Required for the spliceosome assembly and initiation of the DNA replication (By similarity).


ensembl_gene_id: Q5AED9
symbol: BBP
gene_biotype: protein_coding
description:
  Branchpoint-bridging protein; Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns (By similarity). Belongs to the BBP/SF1 family.


ensembl_gene_id: Q5AEE1
symbol: HTZ1
gene_biotype: protein_coding
description:
  Histone H2A.Z; Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activa [...]


ensembl_gene_id: Q5AEF2
symbol: SEC13
gene_biotype: protein_coding
description:
  Protein transport protein SEC13; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. It also functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport facto [...]


ensembl_gene_id: Q5AEG7
symbol: PGA18
gene_biotype: protein_coding
description:
  Probable GPI-anchored adhesin-like protein PGA18; Cell wall protein which mediates cell-cell and cell-substrate adhesion. Required for biofilm formation and plays a role in virulence (By similarity); Belongs to the PGA18 family.


ensembl_gene_id: Q5AEI2
symbol: ATG10
gene_biotype: protein_coding
description:
  Ubiquitin-like-conjugating enzyme ATG10; E2-like enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy and nucleophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for proper localization of ATG8 to the preautophagosomal structure (PAS). Likely serves as an ATG5-recognition molecule (By similarity); Belongs to the ATG10 family.


ensembl_gene_id: Q5AEI3
symbol: CaO19.285
gene_biotype: protein_coding
description:
  mRNA stability protein; Plays an essential role in initiation of the G0 program by preventing the degradation of specific nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway.


ensembl_gene_id: Q5AEJ3
symbol: CaO19.275
gene_biotype: protein_coding
description:
  Ribonuclease P/MRP protein subunit POP5; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Belongs to the eukaryotic/archaeal RNase P protein component 2 family.


ensembl_gene_id: Q5AEK8
symbol: SLD1
gene_biotype: protein_coding
description:
  Delta 8-(E)-sphingolipid desaturase; Delta(8)-fatty-acid desaturase which introduces a double bond at the 8-position in the long-chain base (LCB) of ceramides. Required for the formation of the di-unsaturated sphingoid base (E,E)-sphinga- 4,8-dienine during glucosylceramide (GluCer) biosynthesis.


ensembl_gene_id: Q5AEL8
symbol: SLC1
gene_biotype: protein_coding
description:
  1-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.


ensembl_gene_id: Q5AEM5
symbol: OXR1
gene_biotype: protein_coding
description:
  Oxidation resistance protein 1; May be involved in protection from oxidative damage. Belongs to the OXR1 family.


ensembl_gene_id: Q5AEM6
symbol: SAP8
gene_biotype: protein_coding
description:
  Candidapepsin-8; Secreted aspartic peptidases (SAPs) are a group of ten acidic hydrolases considered as key virulence factors. These enzymes supply the fungus with nutrient amino acids as well as are able to degrade the selected host's proteins involved in the immune defense. Serves as a major regulator of MSB2-processing which activates CEK1 MAPK-signaling affecting biofilm formation and oropharyngeal candidiasis. Moreover, acts toward human hemoglobin though limited proteolysis to generate a variety of antimicrobial hemocidins, enabling to compete with the other microorganisms of the [...]


ensembl_gene_id: Q5AEM8
symbol: PAM17
gene_biotype: protein_coding
description:
  Presequence translocated-associated motor subunit PAM17, mitochondrial; Component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.


ensembl_gene_id: Q5AEN1
symbol: CCP1
gene_biotype: protein_coding
description:
  Cytochrome c peroxidase, mitochondrial; Destroys radicals which are normally produced within the cells and which are toxic to biological systems.


ensembl_gene_id: Q5AEN6
symbol: MED7
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 7; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).


ensembl_gene_id: Q5AF03
symbol: GLX3
gene_biotype: protein_coding
description:
  Glyoxalase 3; Catalyzes the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step. Selective for MG, does not use glyoxal as substrate. Plays a role in detoxifying endogenously produced MG, particularly when glycerol is the principal carbon source. Important for viability in stationary phase (By similarity).


ensembl_gene_id: Q5AF39
symbol: PGA59
gene_biotype: protein_coding
description:
  Cell wall protein PGA59; Cell wall protein necessary for cell wall integrity. Plays only a minor role in hyphal morphogenesis and is not critical to biofilm formation; Belongs to the HWP1 family.


ensembl_gene_id: Q5AF41
symbol: PGA62
gene_biotype: protein_coding
description:
  Cell wall protein PGA62; Cell wall protein necessary for cell wall integrity. plays only a minor role in hyphal morphogenesis and is not critical to biofilm formation; Belongs to the HWP1 family.


ensembl_gene_id: Q5AF54
symbol: TIM13
gene_biotype: protein_coding
description:
  Mitochondrial import inner membrane translocase subunit TIM13; Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIM8- TIM13 complex is non essential and only mediates [...]


ensembl_gene_id: Q5AF73
symbol: SEN2
gene_biotype: protein_coding
description:
  tRNA-splicing endonuclease subunit Sen2; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural [...]


ensembl_gene_id: Q5AF95
symbol: DBP4
gene_biotype: protein_coding
description:
  ATP-dependent RNA helicase DBP4; ATP-dependent RNA helicase required for ribosome biogenesis. Involved in the release of U14 snoRNA in pre-ribosomal complexes. Required for pre-rRNA cleavage at site A2 (By similarity).


ensembl_gene_id: Q5AFA2
symbol: CRH11
gene_biotype: protein_coding
description:
  Extracellular glycosidase CRH11; Extracellular glycosidase which plays an important role in fungal pathogenesis. Involved in cell wall assembly and regeneration, filamentation, and adherence to host cells.


ensembl_gene_id: Q5AFE4
symbol: RVS161
gene_biotype: protein_coding
description:
  Regulator of cytoskeleton and endocytosis RVS161; Component of a cytoskeletal structure that is required for the formation of endocytic vesicles at the plasma membrane level. Plays an important role in virulence.


ensembl_gene_id: Q5AFF7
symbol: FIS1
gene_biotype: protein_coding
description:
  Mitochondrial fission 1 protein; Has a role in mitochondrial fission. Has a role in outer membrane fission but not matrix separation (By similarity).


ensembl_gene_id: Q5AFG1
symbol: ALB1
gene_biotype: protein_coding
description:
  Ribosome biogenesis protein ALB1; Involved in proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit. Accompanies the pre-60S particles to the cytoplasm (By similarity).


ensembl_gene_id: Q5AFH3
symbol: FEX1
gene_biotype: protein_coding
description:
  Fluoride export protein 1; Fluoride channel required for the rapid expulsion of cytoplasmic fluoride.


ensembl_gene_id: Q5AFI4
symbol: DFI1
gene_biotype: protein_coding
description:
  Cell-surface associated glycoprotein DFI1; Cell-surface associated glycoprotein that acts as a plasma membrane receptor-type protein which senses the presence of matrix. Binds to calmodulin in response to environmental conditions and initiates a signaling cascade that activates CEK1, thus promoting invasive filamentation. Involved in the maintenance of the cell wall.


ensembl_gene_id: Q5AFK0
symbol: MAC1
gene_biotype: protein_coding
description:
  Metal-binding activator 1; Copper ion-sensing transcription factor which activates transcription of the CTR1 copper transporter under low-copper conditions. Promotes filamentous and invasive growth.


ensembl_gene_id: Q5AFK3
symbol: PSF3
gene_biotype: protein_coding
description:
  DNA replication complex GINS protein PSF3; The GINS complex plays an essential role in the initiation of DNA replication.


ensembl_gene_id: Q5AFN8
symbol: SSR1
gene_biotype: protein_coding
description:
  Covalently-linked cell wall protein 14; Beta-glucan associated cell wall protein involved in cell wall structure. May serve as cross-linking or coat-forming wall protein.


ensembl_gene_id: Q5AFP3
symbol: MCM1
gene_biotype: protein_coding
description:
  Transcription factor of morphogenesis MCM1; Transcription factor that is recruited by AHR1 to the promoters of genes involved in biofilm formation, which include several key adhesion genes. Plays an important role in cell adhesion, hyphal growth and virulence. Implicated in the regulation of opaque-phase- specific gene expression.


ensembl_gene_id: Q5AFP8
symbol: KEX1
gene_biotype: protein_coding
description:
  Pheromone-processing carboxypeptidase KEX1; Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).


ensembl_gene_id: Q5AFT2
symbol: GPI11
gene_biotype: protein_coding
description:
  Glycosylphosphatidylinositol anchor biosynthesis protein 11; Acts in the GPI biosynthetic pathway between GlcNAc-PI synthesis and GPI transfer to protein.


ensembl_gene_id: Q5AFT3
symbol: CFT1
gene_biotype: protein_coding
description:
  Protein CFT1; RNA-binding component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation- dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. Involved in poly(A) site recognition. May be involved in coupling transcription termination and mRNA 3'-end formation (By similarity); Belongs to the CFT1 family.


ensembl_gene_id: Q5AFV3
symbol: SLX4
gene_biotype: protein_coding
description:
  Structure-specific endonuclease subunit SLX4; Regulatory subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.


ensembl_gene_id: Q5AFX2
symbol: CDC123
gene_biotype: protein_coding
description:
  Cell division cycle protein 123; Regulates the cell cycle in a nutrient dependent manner. Belongs to the CDC123 family.


ensembl_gene_id: Q5AG31
symbol: MED14
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).


ensembl_gene_id: Q5AG40
symbol: VPS4
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 4; Pre-vacuolar protein sorting protein involved in the transport of biosynthetic membrane proteins from the prevacuolar/endosomal compartment to the vacuole. Required for multivesicular body (MVB) protein sorting. Catalyzes the ATP-dependent dissociation of class E VPS proteins from endosomal membranes, such as the disassembly of the ESCRT-III complex. Required for extracellular secretion of the secreted aspartyl proteases SAP2, SAP4, SAP5, and SAP6. Its regulation of the pre-vacuolar secretory pathway is critical for virulence.


ensembl_gene_id: Q5AG71
symbol: HSL1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase HSL1; Protein kinase involved in determination of morphology during the cell cycle of both yeast-form and hyphal cells via regulation of SWE1 and CDC28. Regulates pseudohypha formation, but is not required for septin ring organization or septum formation. Plays an essential role in virulence in a mouse model; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.


ensembl_gene_id: Q5AG73
symbol: MDE1
gene_biotype: protein_coding
description:
  Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).


ensembl_gene_id: Q5AG77
symbol: GAP1
gene_biotype: protein_coding
description:
  Amino-acid permease GAP1; Amino-acid permease that coordinates external nitrogen source response and morphogenesis. Is capable of transporting several structurally unrelated amino acids such as leucine and phenylalanine, though with a lower capacity than the GAP2 and GAP6 permeases. Has citrulline import activity. GAP1 is also able to transport thialysine, and thus probably also lysine. Functions as a sensor via detection of some amino acids including methionine, leading to a rapid activation of trehalase, a downstream target of PKA ; Belongs to the amino acid-polyamine-organocation (A [...]


ensembl_gene_id: Q5AG86
symbol: CIA1
gene_biotype: protein_coding
description:
  Probable cytosolic iron-sulfur protein assembly protein 1; Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.


ensembl_gene_id: Q5AG97
symbol: IFH1
gene_biotype: protein_coding
description:
  Transcriptional regulator IFH1; In complex with IFH1, acts as a transcriptional regulator of rRNA and ribosomal protein genes. The FHL1-IFH1 complex is targeted to the ribosomal protein genes by the DNA-binding factor TBF1.


ensembl_gene_id: Q5AGA0
symbol: MNN1
gene_biotype: protein_coding
description:
  Putative alpha-1,3-mannosyltransferase MNN1; Responsible for addition of the terminal mannose residues to the outer chain of core N-linked polysaccharides and to O-linked mannotriose. Implicated in late Golgi modifications (By similarity). Belongs to the MNN1/MNT family.


ensembl_gene_id: Q5AGA9
symbol: MNN13
gene_biotype: protein_coding
description:
  Putative alpha-1,3-mannosyltransferase MNN13; Responsible for addition of the terminal mannose residues to the outer chain of core N-linked polysaccharides and to O-linked mannotriose. Implicated in late Golgi modifications (By similarity). Belongs to the MNN1/MNT family.


ensembl_gene_id: Q5AGC1
symbol: FIP1
gene_biotype: protein_coding
description:
  Pre-mRNA polyadenylation factor FIP1; Pre-mRNA polyadenylation factor that directly interacts with poly(A) polymerase; Belongs to the FIP1 family.


ensembl_gene_id: Q5AGC4
symbol: ECM331
gene_biotype: protein_coding
description:
  Cell surface GPI-anchored protein ECM33; Cell surface protein required for proper cell wall integrity and for the correct assembly of the mannoprotein outer layer of the cell wall.


ensembl_gene_id: Q5AGC7
symbol: BUD32
gene_biotype: protein_coding
description:
  EKC/KEOPS complex subunit BUD32; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is r [...]


ensembl_gene_id: Q5AGD1
symbol: CaO19.4248
gene_biotype: protein_coding
description:
  Acyl-protein thioesterase 1; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins with a strong preference for palmitoylated G-alpha proteins over other acyl substrates.


ensembl_gene_id: Q5AGE5
symbol: CTR86
gene_biotype: protein_coding
description:
  Copper transport protein 86; Essential protein which may be involved in threonine biosynthesis; Belongs to the CTR86 family.


ensembl_gene_id: Q5AGM0
symbol: HIR2
gene_biotype: protein_coding
description:
  Protein HIR2; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family.


ensembl_gene_id: Q5AGV4
symbol: PRT1
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 3 subunit B; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.


ensembl_gene_id: Q5AGV7
symbol: PFA4
gene_biotype: protein_coding
description:
  Palmitoyltransferase PFA4; Mediates the reversible addition of palmitate to target proteins, thereby regulating their membrane association and biological function; Belongs to the DHHC palmitoyltransferase family. PFA4 subfamily.


ensembl_gene_id: Q5AGW8
symbol: NUP
gene_biotype: protein_coding
description:
  Purine nucleoside permease; Nucleoside permease that transports adenosine and guanosine. Does not show any transport activities towards cytidine, adenine, guanine, uridine, and uracil.


ensembl_gene_id: Q5AGX6
symbol: RNH35
gene_biotype: protein_coding
description:
  Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.


ensembl_gene_id: Q5AGX8
symbol: LAT1
gene_biotype: protein_coding
description:
  Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).


ensembl_gene_id: Q5AGY7
symbol: CaO19.6551
gene_biotype: protein_coding
description:
  Golgi SNAP receptor complex member 1; Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor.


ensembl_gene_id: Q5AGZ0
symbol: ISU1
gene_biotype: protein_coding
description:
  Iron-sulfur cluster assembly protein; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.


ensembl_gene_id: Q5AGZ8
symbol: PFK2
gene_biotype: protein_coding
description:
  ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.


ensembl_gene_id: Q5AGZ9
symbol: RVB2
gene_biotype: protein_coding
description:
  RuvB-like helicase 2; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity); Belongs to the RuvB family.


ensembl_gene_id: Q5AH02
symbol: IQG1
gene_biotype: protein_coding
description:
  Ras GTPase-activating-like protein IQG1; Required for the assembly and the contraction of the actomyosin ring at the bud neck during cytokinesis.


ensembl_gene_id: Q5AH09
symbol: CDC34
gene_biotype: protein_coding
description:
  SCF E2 ubiquitin-protein ligase catalytic subunit; Belongs to the ubiquitin-conjugating enzyme family.


ensembl_gene_id: Q5AH25
symbol: EXO70
gene_biotype: protein_coding
description:
  Exocyst complex protein EXO70; Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Also plays a role in the assembly of the exocyst (By similarity). Belongs to the EXO70 family.


ensembl_gene_id: Q5AH38
symbol: ECM42
gene_biotype: protein_coding
description:
  Arginine biosynthesis bifunctional protein ArgJ, mitochondrial; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate.


ensembl_gene_id: Q5AH60
symbol: TRM82
gene_biotype: protein_coding
description:
  tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit TRM82; Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit. Belongs to the WD repeat TRM82 family.


ensembl_gene_id: Q5AH72
symbol: CaO19.6461
gene_biotype: protein_coding
description:
  Cytochrome c oxidase assembly protein COX20, mitochondrial; Involved in the assembly of the cytochrome c oxidase complex. Belongs to the COX20 family.


ensembl_gene_id: Q5AH87
symbol: STP4
gene_biotype: protein_coding
description:
  Transcriptional regulator STP4; Probable transcription factor involved in response to cell wall damage.


ensembl_gene_id: Q5AHA0
symbol: CHK1
gene_biotype: protein_coding
description:
  Histidine protein kinase 1; Histidine kinase involved in a two-component signaling pathway that regulates cell wall mannan and glucan biosynthesis. Regulates quorum sensing as well as hyphal formation, biofilm formation, chlamidospore formation, and virulence. Plays a prominent role in phagocyte activation. Involved in the covering of the most potent proinflammatory cell wall molecules, the beta-glucans, underneath a dense mannan layer, so that the pathogen becomes partly invisible for immune cells such as phagocytes.


ensembl_gene_id: Q5AHA4
symbol: PGA17
gene_biotype: protein_coding
description:
  Predicted GPI-anchored protein 17; Predicted GPI-anchored protein which may have a role during host infection.


ensembl_gene_id: Q5AHA6
symbol: CaO19.891
gene_biotype: protein_coding
description:
  AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.


ensembl_gene_id: Q5AHB1
symbol: PAN1
gene_biotype: protein_coding
description:
  Actin cytoskeleton-regulatory complex protein PAN1; Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).


ensembl_gene_id: Q5AHB8
symbol: YNG2
gene_biotype: protein_coding
description:
  Chromatin modification-related protein YNG2; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in cell cycle progression and meiosis (By similarity); Belongs to the ING family.


ensembl_gene_id: Q5AHC2
symbol: MGR1
gene_biotype: protein_coding
description:
  Mitochondrial inner membrane i-AAA protease complex subunit MGR1; Component of the mitochondrial inner membrane i-AAA protease complex required for mitochondrial inner membrane protein turnover.


ensembl_gene_id: Q5AHD6
symbol: BMT8
gene_biotype: protein_coding
description:
  Beta-mannosyltransferase 8; Beta-mannosyltransferase involved in cell wall biosynthesis through beta-1,2-mannosylation of cell wall phosphopeptidomannan (By similarity). Plays a role in the ability to produce hyphae in the presence of three bacterial species.


ensembl_gene_id: Q5AHE8
symbol: PGA16
gene_biotype: protein_coding
description:
  Virulence factor PGA16; Cell surface GPI-anchored protein required for virulence. Mediates hyphal ramification which is important for the interaction with host cells.


ensembl_gene_id: Q5AHF9
symbol: GNA1
gene_biotype: protein_coding
description:
  Glucosamine 6-phosphate N-acetyltransferase; Belongs to the acetyltransferase family. GNA1 subfamily.


ensembl_gene_id: Q5AHG6
symbol: SCH9
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase SCH9; Protein kinase that is part of growth control pathway which is at least partially redundant with the cAMP pathway (By similarity). Plays a role in filamentous growth and virulence. Prevents hypha formation specifically under hypoxia at high CO(2) levels. Required for chlamydospore formation, distinctive morphological feature of the fungal pathogen C.albicans that can be induced to form in oxygen- limited environments and has been reported in clinical specimens.


ensembl_gene_id: Q5AHH0
symbol: MED1
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.


ensembl_gene_id: Q5AHH4
symbol: HSP21
gene_biotype: protein_coding
description:
  Small heat shock protein 21; Heat shock protein required for pathogenicity. Mediates thermotolerance and adaptation to oxidative stress and ethanol-induced stress. Required for invasive growth and filament formation under various filament inducing conditions. Plays a role in the capacity of damaging human-derived endothelial and oral epithelial cells during infection. Potentiates resistance to antifungal drugs, as well as resistance to killing by human neutrophils. Plays a major role in trehalose homeostasis in response to elevated temperatures. Regulates CEK1 activation by phosphoryla [...]


ensembl_gene_id: Q5AHJ5
symbol: TBF1
gene_biotype: protein_coding
description:
  Transcription factor TBF1; Essential transcriptional activator that binds the telomeric double-stranded TTAGGG repeat and negatively regulates telomere length. Involved in the regulation of gene expression. Bind both the promoters of ribosomal protein genes and the rDNA locus and activates transcription at these loci. Recruits FHL1 and IFH1 to promoters.


ensembl_gene_id: Q5AHK2
symbol: SSN3
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase SSN3; Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II (By similarity).


