# geneInfo

ensembl_gene_id: A0ZWU1
symbol: eaf1
gene_biotype: protein_coding
description:
  Ell1-associated factor 1; Activates transcription elongation by RNA polymerase II and pyrophosphorolysis as a complex with ell1. Acts as a transcriptional transactivator of ell1 elongation activities.


ensembl_gene_id: A6X972
symbol: gon7
gene_biotype: protein_coding
description:
  EKC/KEOPS complex subunit gon7; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Gon7 likely plays a supporting role to the catalytic subunit pgp2 in the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptiona [...]


ensembl_gene_id: A6X980
symbol: sfc7
gene_biotype: protein_coding
description:
  Transcription factor tau subunit sfc7; TFIIIC mediates tRNA and 5S RNA gene activation by binding to intragenic promoter elements. Upstream of the transcription start site, TFIIIC assembles the initiation complex TFIIIB-TFIIIC-tDNA, which is sufficient for RNA polymerase III recruitment and function. Part of the tauA domain of TFIIIC that binds boxA DNA promoter sites of tRNA and similar genes (By similarity).


ensembl_gene_id: A9ZLL8
symbol: lsd90
gene_biotype: protein_coding
description:
  Protein lsd90; May be involved in the metabolism of very long-chain fatty acid-containing phospholipids (VLCFA-PL).


ensembl_gene_id: B5BP46
symbol: SPBC460.02c
gene_biotype: protein_coding
description:
  Putative glutathione S-transferase C460.02c; Involved in the oxidative stress response and detoxification.


ensembl_gene_id: B5BP48
symbol: SPBC460.04c
gene_biotype: protein_coding
description:
  Putative alpha-ketoglutarate-dependent sulfonate dioxygenase; Acts as an alpha-ketoglutarate-dependent dioxygenase active on sulfonates.


ensembl_gene_id: B8Y7Y5
symbol: iec5
gene_biotype: protein_coding
description:
  INO80 complex subunit 5; Component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.


ensembl_gene_id: C6Y4A3
symbol: atp19
gene_biotype: protein_coding
description:
  ATP synthase subunit K, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the centr [...]


ensembl_gene_id: C6Y4A7
symbol: emc5
gene_biotype: protein_coding
description:
  ER membrane protein complex subunit 5; The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER).


ensembl_gene_id: C6Y4B3
symbol: pga1
gene_biotype: protein_coding
description:
  GPI mannosyltransferase 2 subunit C167.09; Essential component of the GPI mannosyltransferase 2 complex. Responsible for the transfer of the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly (By similarity).


ensembl_gene_id: C6Y4B6
symbol: nce101
gene_biotype: protein_coding
description:
  Non-classical export protein 1; Involved in a novel pathway of export of proteins that lack a cleavable signal sequence. May be part of the export machinery or may also be a substrate for non-classical export (By similarity). Belongs to the NCE101 family.


ensembl_gene_id: C6Y4C0
symbol: SPAC222.18
gene_biotype: protein_coding
description:
  Putative splicing factor C222.18; Has a role in pre-mRNA splicing where it is involved in spliceosome assembly; Belongs to the splicing factor SR family.


ensembl_gene_id: C6Y4C1
symbol: pet117
gene_biotype: protein_coding
description:
  Protein pet117, mitochondrial; Involved in the assembly of cytochrome c oxidase. Belongs to the PET117 family.


ensembl_gene_id: C6Y4C2
symbol: spo2
gene_biotype: protein_coding
description:
  Sporulation-specific protein 2; Involved in sporulation. Plays a significant role in modification of the spindle pole body prior to spore formation and is required for initiating forespore membrane formation. Assists in the localization of spo13 to the outer surface of the SPB.


ensembl_gene_id: C6Y4C4
symbol: sdh8
gene_biotype: protein_coding
description:
  Succinate dehydrogenase assembly factor 4, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Binds to the flavoprotein subunit sdh1 in its FAD-bound form, blocking the generation of excess reactive oxigen species (ROS) and facilitating its assembly with the iron [...]


ensembl_gene_id: C6Y4C8
symbol: vma21
gene_biotype: protein_coding
description:
  Vacuolar ATPase assembly integral membrane protein vma21; Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum; Belongs to the VMA21 family.


ensembl_gene_id: C6Y4C9
symbol: spo13
gene_biotype: protein_coding
description:
  Sporulation-specific protein 13; Involved in sporulation. Plays a significant role in modification of the spindle pole body prior to spore formation and is required for initiating forespore membrane formation.


ensembl_gene_id: C6Y4D0
symbol: dpb3
gene_biotype: protein_coding
description:
  DNA polymerase epsilon subunit C; As accessory component of the DNA polymerase epsilon (DNA polymerase II) participates in chromosomal DNA replication. It is required during synthesis of the leading and lagging DNA strands at the replication fork and binds at/or near replication origins and moves along DNA with the replication fork. It has 3'-5' proofreading exonuclease activity that correct errors arising during DNA replication. It is also involved in DNA synthesis during DNA repair (By similarity). The dpb3-dpb4 dimer associates with histone deacetylases, chromatin remodelers, and hi [...]


ensembl_gene_id: C6Y4D3
symbol: ecl1
gene_biotype: protein_coding
description:
  Extender of the chronological lifespan protein 1; Involved in chronological cell aging. Extends cell viability after entry into the stationary phase probably through affecting the Pka1-dependent pathway negatively.


ensembl_gene_id: G2TRJ9
symbol: coa3
gene_biotype: protein_coding
description:
  Cytochrome c oxidase assembly factor 3, mitochondrial; Required for assembly of cytochrome c oxidase (complex IV). Belongs to the COA3 family.


ensembl_gene_id: G2TRL2
symbol: wip1
gene_biotype: protein_coding
description:
  Inner kinetochore subunit wip1; Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly. Belongs to the CENP-W/WIP1 family.


ensembl_gene_id: G2TRL7
symbol: spd2
gene_biotype: protein_coding
description:
  S-phase delaying protein 2; Regulates the ribonucleotide reductase activity. Belongs to the DIF1/spd1 family.


ensembl_gene_id: G2TRL9
symbol: ppt2
gene_biotype: protein_coding
description:
  Putative holo-[acyl-carrier-protein] synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.


ensembl_gene_id: G2TRM0
symbol: fmc1
gene_biotype: protein_coding
description:
  ATP synthase assembly factor fmc1, mitochondrial; Needed for the assembly of the mitochondrial F1-F0 complex at high temperature; Belongs to the FMC1 family.


ensembl_gene_id: G2TRM8
symbol: coa2
gene_biotype: protein_coding
description:
  Cytochrome c oxidase assembly factor 2; Required for efficient assembly of cytochrome c oxidase in the mitochondrial inner membrane.


ensembl_gene_id: G2TRN6
symbol: SPAC750.01
gene_biotype: protein_coding
description:
  Putative aryl-alcohol dehydrogenase C750.01; Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.


ensembl_gene_id: G2TRP0
symbol: mim2
gene_biotype: protein_coding
description:
  Mitochondrial import protein 2; Component of the MIM complex required for outer membrane protein import (By similarity). Involved in import of the subset of proteins with multiple alpha-helical transmembrane segments (By similarity).


ensembl_gene_id: G2TRP5
symbol: cox7
gene_biotype: protein_coding
description:
  Cytochrome c oxidase subunit 7; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...]


ensembl_gene_id: G2TRP6
symbol: coa6
gene_biotype: protein_coding
description:
  Cytochrome c oxidase subunit 6B-like protein new16; Involved in cytochrome c oxidase complex assembly and is required for efficient formation of respiratory supercomplexes comprised of complexes III and IV; Belongs to the cytochrome c oxidase subunit 6B family.


ensembl_gene_id: G2TRP7
symbol: tom5
gene_biotype: protein_coding
description:
  Mitochondrial import receptor subunit tom5; Component of the TOM (translocase of outer membrane) receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins.


ensembl_gene_id: G2TRP8
symbol: mzm1
gene_biotype: protein_coding
description:
  Mitochondrial zinc maintenance protein 1, mitochondrial; Assembly factor required for Rieske Fe-S protein RIP1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane. Modulates the mitochondrial matrix zinc pool (By similarity).


ensembl_gene_id: G2TRP9
symbol: cox20
gene_biotype: protein_coding
description:
  Cytochrome c oxidase assembly protein cox20, mitochondrial; Involved in the assembly of the cytochrome oxidase complex. Required for the maturation and subsequent assembly of the mitochondrially encoded cox2, the precursor of subunit 2 of cytochrome oxidase (By similarity); Belongs to the COX20 family.


ensembl_gene_id: G2TRR4
symbol: spc1
gene_biotype: protein_coding
description:
  Microsomal signal peptidase subunit 1; Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Signal peptide cleavage occurs during the translocation (cotranslationally or post- translationally) through the translocon pore into the endoplasmic reticulum (By similarity).


ensembl_gene_id: G2TRT0
symbol: ric8
gene_biotype: protein_coding
description:
  Synembryn-like protein C3E7.04c; Probable guanine nucleotide exchange factor (GEF). Belongs to the synembryn family.


ensembl_gene_id: G2TRT1
symbol: SPBC1348.12
gene_biotype: protein_coding
description:
  Probable transcriptional repressor C1348.12; Probable transcriptional repressor of multidrug resistance genes.


ensembl_gene_id: G2TRT3
symbol: tam14
gene_biotype: protein_coding
description:
  Protein tam14; May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation (By similarity).


ensembl_gene_id: G2TRT6
symbol: SPCC417.16
gene_biotype: protein_coding
description:
  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 homolog; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).


ensembl_gene_id: G2TRU0
symbol: ost5
gene_biotype: protein_coding
description:
  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit ost5; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the [...]


ensembl_gene_id: G2TRU5
symbol: cmc2
gene_biotype: protein_coding
description:
  COX assembly mitochondrial protein 2; Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration.


ensembl_gene_id: O00087
symbol: dld1
gene_biotype: protein_coding
description:
  Dihydrolipoyl dehydrogenase, mitochondrial; Lipoamide dehydrogenase is a component of the alpha-ketoacid dehydrogenase complexes (By similarity). Malfunction of this protein blocks the progression of cell cycle from G1 to S phase; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.


ensembl_gene_id: O00091
symbol: zwf1
gene_biotype: protein_coding
description:
  Glucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis (By similarity).


ensembl_gene_id: O00102
symbol: ubc7
gene_biotype: protein_coding
description:
  Ubiquitin-conjugating enzyme E2-18 kDa; Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in degradation of misfolded or regulated proteins localized in the endoplasmic reticulum (ER) lumen or membrane via the ubiquitin-proteasome system. Cognate E2 conjugating enzyme for the doa10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of membrane proteins with misfolded cytoplasmic domains, and of the hrd1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradatio [...]


ensembl_gene_id: O00103
symbol: ubc11
gene_biotype: protein_coding
description:
  Ubiquitin-conjugating enzyme E2-20 kDa; Catalyzes the covalent attachment of ubiquitin to other proteins.


ensembl_gene_id: O13282
symbol: taf5
gene_biotype: protein_coding
description:
  Transcription initiation factor TFIID subunit 5; TAFs are components of the transcription factor IID (TFIID) complex that are essential for mediating regulation of RNA polymerase transcription. Regulates the genes involved in ubiquitin-dependent proteolysis during the progression of M-phase of mitosis.


ensembl_gene_id: O13286
symbol: srw1
gene_biotype: protein_coding
description:
  WD repeat-containing protein srw1; Has a role in cell differentiation and cell cycling by negatively regulating cig2 and cdc12-associated cdc2. Down-regulates the level of cdc13, particularly in a nitrogen deprived environment. Regulator of cell cycle G1 phase progression. Prevents onset of mitosis during the pre-Start G1 period. Required for degradation of cdc13 mitotic cyclin B during G1 arrest but not during mitotic exit.


ensembl_gene_id: O13290
symbol: dhc1
gene_biotype: protein_coding
description:
  Dynein heavy chain, cytoplasmic; Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required for nuclear movement during meiotic prophase.


ensembl_gene_id: O13298
symbol: hos2
gene_biotype: protein_coding
description:
  Histone deacetylase phd1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Is not essential.


ensembl_gene_id: O13310
symbol: orb6
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase orb6; Interacts with pak1/shk1 and coordinates cell morphogenesis with the cell cycle. It is essential for maintenance of cell polarity and is involved in mitotic control.


ensembl_gene_id: O13326
symbol: met17
gene_biotype: protein_coding
description:
  Homocysteine synthase; Catalyzes the conversion of O-acetyl-L-homoserine (OAH) into homocysteine in the methionine biosynthesis pathway. Can also use O-succinyl-L-homoserine and L-homoserine as substrates. Has also cysteine synthase (O- acetylserine sulfhydrylase) activity in vitro, but in S.pombe, it seems only to be involved in the alternative pathway of methionine biosynthesis under cysteine deficiency conditions. Belongs to the trans-sulfuration enzymes family.


ensembl_gene_id: O13339
symbol: trt1
gene_biotype: protein_coding
description:
  Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.


ensembl_gene_id: O13351
symbol: pmt3
gene_biotype: protein_coding
description:
  Ubiquitin-like protein pmt3/smt3; Required for chromosome segregation where it may be involved in microtubule assembly. Loss of smt3 leads to an increase in telomere length; Belongs to the ubiquitin family. SUMO subfamily.


ensembl_gene_id: O13370
symbol: sum3
gene_biotype: protein_coding
description:
  ATP-dependent RNA helicase ded1; ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity). Inactivation of ded1 blocks mitotic cell cycle progression at G1 and G2/M. Induces sexual development and ascus formation.


ensembl_gene_id: O13453
symbol: pmp1
gene_biotype: protein_coding
description:
  Tyrosine-protein phosphatase pmp1; Dual specificity phosphatase that dephosphorylates MAP kinase pmk1 on a Tyr. Has a role in chloride ion homeostasis by inactivating this pmk1 MAP kinase pathway; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.


ensembl_gene_id: O13600
symbol: sws1
gene_biotype: protein_coding
description:
  Zinc finger SWIM domain-containing protein sws1; Involved in early stages of the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents.


ensembl_gene_id: O13601
symbol: rsp1
gene_biotype: protein_coding
description:
  DnaJ-related protein rsp1; Has a role in the proper organization of the interphase microtubule cytoskeleton. Required for equatorial microtubule organizing center (eMTOC) disassembly into satellites, contributing to the dynamic redistribution of MTOC components for organization of interphase microtubules.


ensembl_gene_id: O13602
symbol: mrps28
gene_biotype: protein_coding
description:
  Probable 37S ribosomal protein S28, mitochondrial; Essential component of the small mitochondrial ribosomal subunit; Belongs to the universal ribosomal protein uS15 family.


ensembl_gene_id: O13606
symbol: mei4
gene_biotype: protein_coding
description:
  Meiosis-specific transcription factor mei4; Functions as a meiosis-specific transcription factor. Binds to the 5'-GTAAAYA-3' consensus sequence of the promoter of the spo6 gene.


ensembl_gene_id: O13610
symbol: utp24
gene_biotype: protein_coding
description:
  rRNA-processing protein fcf1; Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly. Required for the early cleavage steps of 35S rRNA at the A(0), A(1), and A(2) sites (By similarity). Belongs to the UTP23/FCF1 family. FCF1 subfamily.


ensembl_gene_id: O13612
symbol: nep2
gene_biotype: protein_coding
description:
  NEDD8-specific protease 2; Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as the pcu1, pcu2 and pcu4 cullins and other proteins (By similarity). Has a role in meiosis; Belongs to the peptidase C48 family.


ensembl_gene_id: O13615
symbol: prp5
gene_biotype: protein_coding
description:
  Pre-mRNA-splicing factor prp5; Required for both cell cycle progression at G2/M and pre-mRNA splicing. Interacts genetically with the PRP4 kinase. Belongs to the WD repeat PRL1/PRL2 family.


ensembl_gene_id: O13620
symbol: mrd1
gene_biotype: protein_coding
description:
  Multiple RNA-binding domain-containing protein 1; Involved in pre-rRNA processing; Belongs to the RRM MRD1 family.


ensembl_gene_id: O13622
symbol: mss116
gene_biotype: protein_coding
description:
  ATP-dependent RNA helicase mss116, mitochondrial; ATP-dependent RNA helicase required for mitochondrial splicing of group I and II introns. Also required for efficient mitochondrial translation (By similarity); Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.


ensembl_gene_id: O13629
symbol: aim22
gene_biotype: protein_coding
description:
  Putative lipoate-protein ligase A; Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes.


ensembl_gene_id: O13632
symbol: SPBC17A3.06
gene_biotype: protein_coding
description:
  Tyrosine-protein phosphatase yvh1; May be directly involved in signal transduction and/or cell cycle regulation. It is necessary for maintaining growth rate or spore germination. Could show both activity toward tyrosine-protein phosphate as well as with serine-protein phosphate (By similarity).


ensembl_gene_id: O13636
symbol: tim50
gene_biotype: protein_coding
description:
  Mitochondrial import inner membrane translocase subunit tim50; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to direct preproteins in transit and direct them to the channel protein TIM23, and possibly facilitates transfer of the translocating proteins from the TOM complex to the TIM23 complex (By similarity).


ensembl_gene_id: O13637
symbol: sec31
gene_biotype: protein_coding
description:
  Protein transport protein sec31; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity).


ensembl_gene_id: O13639
symbol: SPBC8D2.18c
gene_biotype: protein_coding
description:
  Adenosylhomocysteinase; Adenosylhomocysteine is a competitive inhibitor of S- adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.


ensembl_gene_id: O13642
symbol: lip5
gene_biotype: protein_coding
description:
  Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives; Belongs to the radical SAM superfamily. Lipoyl synthase family.


ensembl_gene_id: O13644
symbol: sed5
gene_biotype: protein_coding
description:
  Integral membrane protein sed5; Required for vesicular transport between the endoplasmic reticulum and the Golgi complex. Acts as a target organelle soluble NSF attachment protein receptor (t-SNARE) (By similarity); Belongs to the syntaxin family.


ensembl_gene_id: O13648
symbol: rmt3
gene_biotype: protein_coding
description:
  Ribosomal protein arginine N-methyltransferase rmt3; Methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in ribosomal protein rps2. Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.


ensembl_gene_id: O13652
symbol: sfi1
gene_biotype: protein_coding
description:
  Protein sfi1; Component of the spindle pole body (SPB) half-bridge involved in the initial steps of SPB duplication; Belongs to the SFI1 family.


ensembl_gene_id: O13656
symbol: tom40
gene_biotype: protein_coding
description:
  Probable mitochondrial import receptor subunit tom40; Channel-forming protein essential for import of protein precursors into mitochondria.


ensembl_gene_id: O13663
symbol: gpi13
gene_biotype: protein_coding
description:
  GPI ethanolamine phosphate transferase 3; Involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI third mannose which links the GPI-anchor to the C-terminus of the proteins by an amide bond. Involved in cell wall biosynthesis (By similarity); Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.


ensembl_gene_id: O13665
symbol: far11
gene_biotype: protein_coding
description:
  Factor arrest protein 11; Participates in the control of the reentry into the cell cycle following pheromone treatment; Belongs to the FAR11 family.


ensembl_gene_id: O13666
symbol: erg32
gene_biotype: protein_coding
description:
  Delta(7)-sterol 5(6)-desaturase erg32; Catalyzes the introduction of a C-5 double bond in the B ring of ergosterol. Involved in the biosynthesis or ergosterol which is important for plasma membrane structure and function and for localization of plasma membrane proteins. Belongs to the sterol desaturase family.


ensembl_gene_id: O13670
symbol: ips1
gene_biotype: protein_coding
description:
  Protein MTO1 homolog, mitochondrial; Involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs. Belongs to the MnmG family.


ensembl_gene_id: O13671
symbol: kap109
gene_biotype: protein_coding
description:
  Importin-alpha re-exporter; Export receptor for importin alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates have been released into the nucleoplasm (By similarity).


ensembl_gene_id: O13681
symbol: ima1
gene_biotype: protein_coding
description:
  Integral inner nuclear membrane protein ima1; Inner nuclear membrane protein that specifically binds to heterochromatic regions and promotes the tethering of centromeric DNA to the SUN-KASH complex. Couples centromeres to the nuclear envelope, thus contributing to their association with the microtubule organizing center attachment site and to the positioning of the nucleus at the cell center by microtubules.


ensembl_gene_id: O13682
symbol: swr1
gene_biotype: protein_coding
description:
  Helicase swr1; Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling; Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.


ensembl_gene_id: O13684
symbol: csm1
gene_biotype: protein_coding
description:
  Monopolin complex subunit pcs1; The monopolin-like pcs1/mde4 complex is essential for accurate chromosome segregation during mitosis and meiosis II. May clamp together microtubule binding sites on the same kinetochore, preventing merotelic attachment of microtubules. In contrast to its S.cerevisiae ortholog CSM1, is not required ofr mono-orientation during meiosis I.


ensembl_gene_id: O13685
symbol: ubc13
gene_biotype: protein_coding
description:
  Ubiquitin-conjugating enzyme E2 13; Has a role in the DNA error-free postreplication repair (PRR) pathway. The ubc13/spm2 heterodimer catalyzes the synthesis of non- canonical poly-ubiquitin chains that are linked through 'Lys-63'. Belongs to the ubiquitin-conjugating enzyme family.


ensembl_gene_id: O13686
symbol: sea3
gene_biotype: protein_coding
description:
  Uncharacterized RWD, RING finger and WD repeat-containing protein C11E3.05; May be involved in telomere capping.


ensembl_gene_id: O13687
symbol: vma4
gene_biotype: protein_coding
description:
  V-type proton ATPase subunit E; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.


ensembl_gene_id: O13688
symbol: nse6
gene_biotype: protein_coding
description:
  Non-structural maintenance of chromosome element 6; Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks. May prevent formation of excessive Holliday junctions or assist in their resolution.


ensembl_gene_id: O13691
symbol: SPAC11E3.12
gene_biotype: protein_coding
description:
  NADH-ubiquinone oxidoreductase 24 kDa subunit homolog C11E3.12, mitochondrial; Belongs to the complex I 24 kDa subunit family.


ensembl_gene_id: O13692
symbol: gas5
gene_biotype: protein_coding
description:
  1,3-beta-glucanosyltransferase gas5; Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.


ensembl_gene_id: O13696
symbol: idh1
gene_biotype: protein_coding
description:
  Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial; Performs an essential role in the oxidative function of the citric acid cycle. Also binds RNA; specifically to the 5'-untranslated leaders of mitochondrial mRNAs.


ensembl_gene_id: O13698
symbol: mct1
gene_biotype: protein_coding
description:
  Malonyl CoA-acyl carrier protein transacylase, mitochondrial; Involved in biosynthesis of fatty acids in mitochondria. Belongs to the FabD family.


ensembl_gene_id: O13701
symbol: taf7
gene_biotype: protein_coding
description:
  Transcription initiation factor TFIID subunit 7; TAFs are components of the transcription factor IID (TFIID) complex that are essential for mediating regulation of RNA polymerase transcription. Also involved in the transport of mRNA from the nucleus to the cytoplasm.


ensembl_gene_id: O13702
symbol: gld1
gene_biotype: protein_coding
description:
  Glycerol dehydrogenase 1; Glycerol dehydrogenase involved in the assimilation of glycerol; Belongs to the iron-containing alcohol dehydrogenase family.


ensembl_gene_id: O13703
symbol: vta1
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein vts1; Has a role in the formation of the multivesicular body (MVB). Required for the sorting of lipids to form intralumenal vesicles and for fluid-phase transport to the vacuole. Required for sorting several plasma membrane proteins into the MVB (By similarity).


ensembl_gene_id: O13705
symbol: sec10
gene_biotype: protein_coding
description:
  Exocyst complex component sec10; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane; Belongs to the SEC10 family.


ensembl_gene_id: O13710
symbol: smc5
gene_biotype: protein_coding
description:
  Structural maintenance of chromosomes protein 5; Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks. Plays a critical role in meiosis.


ensembl_gene_id: O13713
symbol: nab2
gene_biotype: protein_coding
description:
  Nuclear polyadenylated RNA-binding protein nab2; Binds to polyadenylated RNA and single-stranded DNA. It may be involved not only in RNA processing but also in transcription regulation. Believed to associate directly with nascent RNA polymerase II transcripts and remain associated during subsequent nuclear RNA processing reactions (By similarity); Belongs to the NAB2 family.


ensembl_gene_id: O13716
symbol: agn1
gene_biotype: protein_coding
description:
  Glucan endo-1,3-alpha-glucosidase agn1; Has a role in cell separation where it is required for the degradation of the cell wall material surrounding the septum (the septum edging) which must be hydrolyzed before full separation of the daughter cells can occur. Hydrolyzes 1,3-alpha-glucan predominantly into pentasaccharides.


ensembl_gene_id: O13718
symbol: vtc2
gene_biotype: protein_coding
description:
  Vacuolar transporter chaperone 2; Component of the vacuolar transporter chaperone (VTC) complex, which plays a role in vacuolar membrane fusion.


ensembl_gene_id: O13719
symbol: laf1
gene_biotype: protein_coding
description:
  SWIRM domain-containing protein laf1; Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.


ensembl_gene_id: O13722
symbol: taf12
gene_biotype: protein_coding
description:
  Transcription initiation factor TFIID subunit 12; Functions as a component of the DNA-binding general transcription factor complex TFIID and the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and SLIK. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin mod [...]


ensembl_gene_id: O13725
symbol: mug182
gene_biotype: protein_coding
description:
  NAD(P)H-hydrate epimerase; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX (By similarity). May have a role in meiosis.


ensembl_gene_id: O13728
symbol: ain1
gene_biotype: protein_coding
description:
  Alpha-actinin-like protein 1; Binds to actin and is involved in actin-ring formation and organization. Plays a role in cytokinesis and is involved in septation. Belongs to the alpha-actinin family.


ensembl_gene_id: O13729
symbol: pun1
gene_biotype: protein_coding
description:
  SUR7 family protein pun1; Contributes to the wild-type cellular response to nitrogen stress through signaling pathways that regulate the expression of genes involved in amino acid biosynthesis. Required for wild-type filamentous growth, cell growth, and cell-cell adhesion (By similarity). Belongs to the SUR7 family.


ensembl_gene_id: O13734
symbol: sgo2
gene_biotype: protein_coding
description:
  Shugoshin-2; Involved in chromosome cohesion during mitosis and meiosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. Required for faithful mitotic chromosome segregation and proper kinetochore orientation during meiosis I. In contrast to sgo1, it is dispensable for centromeric protection of rec8 during meiosis I as well as protection of rad21 during mitosis. Required to sense the lack of tension at centromeres during mitosis.


ensembl_gene_id: O13735
symbol: bud6
gene_biotype: protein_coding
description:
  Actin-interacting protein 3 homolog; Involved in the organization and/or function of the actin cytoskeleton; To yeast BUD6.


ensembl_gene_id: O13736
symbol: shd1
gene_biotype: protein_coding
description:
  Actin cytoskeleton-regulatory complex protein sla1; Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).


ensembl_gene_id: O13738
symbol: gna1
gene_biotype: protein_coding
description:
  Glucosamine 6-phosphate N-acetyltransferase; Belongs to the acetyltransferase family. GNA1 subfamily.


ensembl_gene_id: O13742
symbol: vph1
gene_biotype: protein_coding
description:
  V-type proton ATPase subunit a; Subunit of the integral membrane V0 complex of vacuolar ATPase essential for assembly and catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells (By similarity).


ensembl_gene_id: O13745
symbol: tfb1
gene_biotype: protein_coding
description:
  General transcription and DNA repair factor IIH subunit tfb1; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has be [...]


ensembl_gene_id: O13747
symbol: SPAC16E8.13
gene_biotype: protein_coding
description:
  RING finger protein ETP1 homolog; May act as a cytoplasmic retention protein with a role in regulating nuclear transport.


ensembl_gene_id: O13748
symbol: tae1
gene_biotype: protein_coding
description:
  Alpha N-terminal protein methyltransferase 1; Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif (By similarity).


ensembl_gene_id: O13749
symbol: sua7
gene_biotype: protein_coding
description:
  Transcription initiation factor IIB; General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II.


ensembl_gene_id: O13750
symbol: SPAC16E8.17c
gene_biotype: protein_coding
description:
  Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.


ensembl_gene_id: O13753
symbol: vma6
gene_biotype: protein_coding
description:
  V-type proton ATPase subunit d; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. The active enzyme consists of a catalytic V1 domain attached to an integral membrane V0 proton pore complex. This subunit is a non-integral membrane component of the membrane pore domain and is required for proper assembly of the V0 sector. Might be involved in the regulated assembly of V1 subunits onto the membrane sector or alternatively may prevent the passage of protons through V0 pores; Belongs to the V-ATPase V0D/AC39 subunit family.


ensembl_gene_id: O13754
symbol: cns1
gene_biotype: protein_coding
description:
  Hsp70/Hsp90 co-chaperone cns1; Co-chaperone that binds to the molecular chaperones Hsp90 and Hsp70. Stimulates Hsp70 ATPase activity, but not Hsp90 ATPase activity. Involved in only a subset of Hsp90 functions (By similarity).


ensembl_gene_id: O13755
symbol: osm1
gene_biotype: protein_coding
description:
  Fumarate reductase; Irreversibly catalyzes the reduction of fumarate to succinate; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.


ensembl_gene_id: O13756
symbol: vps8
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 8; Involved in the retention of proteins to the late-Golgi. Plays an integral role in the complex vacuolar protein sorting process (By similarity); Belongs to the VPS8 family.


ensembl_gene_id: O13759
symbol: csx1
gene_biotype: protein_coding
description:
  RNA-binding post-transcriptional regulator csx1; Regulates global gene expression after oxidative stress. Interacts and stabilizes atf1 and pcr1 mRNAs after oxidative stress, thus controlling their turnover.


ensembl_gene_id: O13764
symbol: pex6
gene_biotype: protein_coding
description:
  Peroxisomal ATPase pex6; Component of the peroxisomal protein import machinery. Together with pex1, mediates the ATP-dependent relocation and recycling of the peroxisomal targeting signal-1 (PTS1) import receptor PEX5 from the peroxisomal membrane to the cytosol, where it is then available for another round of protein import into the organelle (By similarity). Belongs to the AAA ATPase family.


ensembl_gene_id: O13765
symbol: dbr1
gene_biotype: protein_coding
description:
  Lariat debranching enzyme; Cleaves the 2'-5' phosphodiester linkage at the branch point of lariat intron pre-mRNAs after splicing and converts them into linear molecules that are subsequently degraded. It thereby facilitates ribonucleotide turnover (By similarity); Belongs to the lariat debranching enzyme family.


ensembl_gene_id: O13768
symbol: ptr8
gene_biotype: protein_coding
description:
  General transcription and DNA repair factor IIH helicase subunit XPB; ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of XPB/ptr8, but not its helicase activity, is required f [...]


ensembl_gene_id: O13772
symbol: hua1
gene_biotype: protein_coding
description:
  Proline/serine-rich protein C17A5.10; May be involved in assembly and disassembly of the actin cytoskeleton.


ensembl_gene_id: O13774
symbol: fol2
gene_biotype: protein_coding
description:
  GTP cyclohydrolase 1; GTP cyclohydrolase 1 is the first enzyme in the biosynthetic pathway leading to folic acid.


ensembl_gene_id: O13775
symbol: gus1
gene_biotype: protein_coding
description:
  Probable glutamate--tRNA ligase, cytoplasmic; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.


ensembl_gene_id: O13776
symbol: ftp105
gene_biotype: protein_coding
description:
  Ubp5-interacting protein ftp105; Required for the localization of ubp5 to the Golgi apparatus. Involved in detoxification of cadmium ion.


ensembl_gene_id: O13779
symbol: mnr2
gene_biotype: protein_coding
description:
  Putative metal ion transporter C17A12.14; Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.


ensembl_gene_id: O13782
symbol: cpp1
gene_biotype: protein_coding
description:
  Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.


ensembl_gene_id: O13783
symbol: bro1
gene_biotype: protein_coding
description:
  Vacuolar protein-sorting protein bro1; Involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles; Belongs to the BRO1 family.


ensembl_gene_id: O13785
symbol: use1
gene_biotype: protein_coding
description:
  Protein transport protein use1; SNARE required for targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.


ensembl_gene_id: O13786
symbol: pep7
gene_biotype: protein_coding
description:
  Vacuolar segregation protein pep7; Required for vacuole segregation and vacuole protein sorting. Possibly part of a complex which tethers the vacuole membrane to microtubules, either directly or via kinesin or dynein-like motor proteins. Probably functions in several interorganelle traffic pathways (By similarity).


ensembl_gene_id: O13787
symbol: sec62
gene_biotype: protein_coding
description:
  Translocation protein sec62; Acts as component of the Sec62/63 complex which is involved in SRP-independent post-translational translocation across the endoplasmic reticulum (ER) and functions together with the Sec61 complex and bip1 in a channel-forming translocon complex. In an initial step, the signal sequence seems to bind simultaneously to sec61 and sec62. sec62 and sec63 are required for interactions between sec61 and translocating polypeptides. sec62 may affect sec61-polypeptide interactions by increasing the affinity of targeting pathways for sec61 and/or by modifying sec61 to  [...]


ensembl_gene_id: O13788
symbol: ssr1
gene_biotype: protein_coding
description:
  SWI/SNF and RSC complexes subunit ssr1; Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. Controls particularly membrane and organelle development genes. Part of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing bindin [...]


ensembl_gene_id: O13789
symbol: SPAC17G6.11c
gene_biotype: protein_coding
description:
  Uncharacterized beta-glucan synthesis-associated protein C17G6.11c; Required for synthesis of the major beta-glucans of the yeast cell wall; Belongs to the SKN1/KRE6 family.


ensembl_gene_id: O13790
symbol: cul1
gene_biotype: protein_coding
description:
  Cullin-1; Core component of multiple cullin-RING-based SCF (SKP1-CUL1- F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(pop1-pop2) is required for the maintenance of ploidy and directs ubiquitination of cig2; Belongs to the cullin family.


ensembl_gene_id: O13792
symbol: uap56
gene_biotype: protein_coding
description:
  ATP-dependent RNA helicase uap56; ATP-binding RNA helicase involved in transcription elongation and required for the export of mRNA out of the nucleus. SUB2 plays also a role in pre-mRNA splicing and spliceosome assembly. May be involved in rDNA and telomeric silencing, and maintenance of genome integrity. Links the mRNA adapter mlo3 to rae1 for targeting mRNA-protein complex to the proteins of the nucleoporin complex (NPC).


ensembl_gene_id: O13793
symbol: fsf1
gene_biotype: protein_coding
description:
  Sideroflexin fsf1; Mitochondrial amino-acid transporter that mediates transport of serine into mitochondria; Belongs to the sideroflexin family.


ensembl_gene_id: O13794
symbol: ysh1
gene_biotype: protein_coding
description:
  Endoribonuclease ysh1; Component of the cleavage factor I (CF I) involved in pre- mRNA 3'-end processing; Belongs to the metallo-beta-lactamase superfamily. RNA- metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.


ensembl_gene_id: O13796
symbol: rqc1
gene_biotype: protein_coding
description:
  Ribosome quality control complex subunit 1; Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Rqc1 is essential for the recruitment of cdc48 to ribosomal subunits.


ensembl_gene_id: O13797
symbol: sgt2
gene_biotype: protein_coding
description:
  Small glutamine-rich tetratricopeptide repeat-containing protein 2; Co-chaperone that binds to the molecular chaperone Hsp70 and regulates Hsp70 ATPase activity; Belongs to the SGT family.


ensembl_gene_id: O13800
symbol: rdl1
gene_biotype: protein_coding
description:
  DNA repair protein rdl1; Involved in homologous recombination where it functions at an early stage of recombination in a pre-recombinogenic complex with rlp1 and sws1. Also has a role at a later stage of recombination in association with the rhp55-rhp57 complex.


ensembl_gene_id: O13807
symbol: ddb1
gene_biotype: protein_coding
description:
  DNA damage-binding protein 1; Component of an E3 ubiquitin-protein ligase that includes cul4 (By similarity). Required for ubiquitination and the subsequent degradation of the DNA replication licensing factor cdt1 and of the ribonucleotide reductase inhibitor spd1. Also required for transcription-coupled nucleotide excision repair.


ensembl_gene_id: O13808
symbol: gmf1
gene_biotype: protein_coding
description:
  Actin-depolymerizing factor gmf1; Actin depolymerizing factor involved in the control of the disassembly of actin patches. Binds and suppresses the arp2/3 complex functions such as the promotion of actin polymerisation and branching filaments.


ensembl_gene_id: O13809
symbol: cyc2
gene_biotype: protein_coding
description:
  Uncharacterized FAD-binding protein C17H9.12c; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.


ensembl_gene_id: O13810
symbol: pro2
gene_biotype: protein_coding
description:
  Probable glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5-oxoproline.


ensembl_gene_id: O13811
symbol: pdi2
gene_biotype: protein_coding
description:
  Protein disulfide-isomerase C17H9.14c; Participates in the folding of proteins containing disulfide bonds, may be involved in glycosylation, prolyl hydroxylation and triglyceride transfer; Belongs to the protein disulfide isomerase family.


ensembl_gene_id: O13813
symbol: tom22
gene_biotype: protein_coding
description:
  Mitochondrial import receptor subunit tom22; Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with tom20 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the translocation pore. Docks tom20 and tom70 for interaction with the general tom40 import pore (GIP) complex. May regulate the TOM machinery organization, stability and channel gating (By similarity).


ensembl_gene_id: O13814
symbol: mdm10
gene_biotype: protein_coding
description:
  Mitochondrial distribution and morphology protein 10; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. mdm10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex). Functions in the tom40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of tom40 with the recepto [...]


ensembl_gene_id: O13816
symbol: psc3
gene_biotype: protein_coding
description:
  Cohesin subunit psc3; Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the rad21 subunit of the cohesin complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Belongs to the SCC3 family.


ensembl_gene_id: O13819
symbol: ymr1
gene_biotype: protein_coding
description:
  Phosphoinositide 3-phosphatase; Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P). Involved in the control of PI3P-dependent signaling and in the maintenance of endosomal system integrity (By similarity).


ensembl_gene_id: O13820
symbol: erg5
gene_biotype: protein_coding
description:
  Cytochrome P450 61; Required to form the C-22(23) double bond in the sterol side chain; Belongs to the cytochrome P450 family.


ensembl_gene_id: O13821
symbol: sst4
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 27; Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.


ensembl_gene_id: O13823
symbol: imp4
gene_biotype: protein_coding
description:
  U3 small nucleolar ribonucleoprotein protein imp4; Component of the U3 small nucleolar ribonucleoprotein. Required for the early cleavages at sites A0, A1 and A2 during 18S ribosomal pre-RNA processing (By similarity).


ensembl_gene_id: O13824
symbol: upf2
gene_biotype: protein_coding
description:
  Nonsense-mediated mRNA decay protein 2; Involved in nonsense-mediated decay of mRNAs containing premature stop codons. It interacts, via its C-terminus, with NAM7/UPF1. Could be involved in determining the efficiency of translational termination or reinitiation or factors involved in the initial assembly of an initiation- and termination-competent mRNP.


ensembl_gene_id: O13825
symbol: yos1
gene_biotype: protein_coding
description:
  Protein transport protein yos1; Required for protein transport between endoplasmic reticulum and Golgi apparatus.


ensembl_gene_id: O13826
symbol: rfp1
gene_biotype: protein_coding
description:
  E3 ubiquitin-protein ligase complex slx8-rfp subunit rfp1; Mediates ubiquitination and subsequent desumoylation/degradation of sumoylated proteins and proteins containing SUMO-like domains. Involved in maintaining genome stability where it acts in the cellular response to DNA damage. Has a role in meiosis.


ensembl_gene_id: O13828
symbol: dcp2
gene_biotype: protein_coding
description:
  mRNA decapping complex subunit 2; Catalytic component of the decapping complex necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense- mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Decapping is the major pathway of mRNA degradation in yeast. It occurs through deadenylation, decapping and subsequent 5' to 3' exonucleolytic decay of the transcript body.


ensembl_gene_id: O13829
symbol: usp101
gene_biotype: protein_coding
description:
  U1 small nuclear ribonucleoprotein 70 kDa homolog; Involved in nuclear mRNA splicing (By similarity). Essential for growth.


ensembl_gene_id: O13830
symbol: pth2
gene_biotype: protein_coding
description:
  Probable peptidyl-tRNA hydrolase 2; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis; Belongs to the PTH2 family.


ensembl_gene_id: O13833
symbol: cid1
gene_biotype: protein_coding
description:
  Terminal uridylyltransferase cid1; Cytoplasmic uridylyltransferase that mediates the terminal uridylation of mRNAs with short poly(A) tails such as such as act1, hcn1 and urg1 mRNAs, hence facilitating global mRNA decay. Uridylates the 3' ends of actin mRNAs upon S-phase arrest. Has also a weak poly(A) polymerase (PAP) activity. Residue His-336 is responsible for the specificity for UTP. Involved in cell cycle arrest where in association with crb2/rhp9 and chk1 it inhibits unscheduled mitosis.


ensembl_gene_id: O13834
symbol: ptr1
gene_biotype: protein_coding
description:
  E3 ubiquitin-protein ligase ptr1; Probable ubiquitin ligase protein involved in mRNA export. E3 ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. Probably participates in mRNA export from the nucleus by regulating the transport of hnRNP proteins such as rae1; Belongs to the UPL family. TOM1/PTR1 subfamily.


ensembl_gene_id: O13835
symbol: imp3
gene_biotype: protein_coding
description:
  U3 small nucleolar ribonucleoprotein protein imp3; Component of the U3 small nucleolar ribonucleoprotein. Required for the early cleavages at sites A0, A1 and A2 during 18S ribosomal pre-RNA processing (By similarity).


ensembl_gene_id: O13836
symbol: din1
gene_biotype: protein_coding
description:
  Decapping nuclease din1; Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping and pyrophosphohydrolase activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA (By similarity). Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5' end triphosphate to release pyrophosphates. Stimulates exoribonuclease activity of rat1, allowing it to degrade RNAs with stable secondary structure more [...]


ensembl_gene_id: O13837
symbol: uga1
gene_biotype: protein_coding
description:
  4-aminobutyrate aminotransferase; Required for the degradation of gamma-aminobutyric acid (GABA), which is important for utilization of GABA as nitrogen source. Deaminates GABA to succinate-semialdehyde, which in turn is converted to succinate by the succinate semialdehyde dehydrogenase. Cannot transaminate beta-alanine (BAL).


ensembl_gene_id: O13838
symbol: nup40
gene_biotype: protein_coding
description:
  Nucleoporin nup40; Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm).


ensembl_gene_id: O13839
symbol: fin1
gene_biotype: protein_coding
description:
  G2-specific protein kinase fin1; Promotes chromosome condensation and nuclear envelope dynamics during mitosis. Activity appears at metaphase-anaphase transition; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. NIMA subfamily.


ensembl_gene_id: O13842
symbol: cda1
gene_biotype: protein_coding
description:
  Chitin deacetylase 1; Hydrolyzes the N-acetamido groups of N-acetyl-D-glucosamine residues in chitin. Required for proper spore formation. Belongs to the polysaccharide deacetylase family.


ensembl_gene_id: O13843
symbol: dal1
gene_biotype: protein_coding
description:
  Ureidoglycolate lyase; Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as secondary nitrogen source when primary sources are limiting (By similarity).


ensembl_gene_id: O13846
symbol: scs7
gene_biotype: protein_coding
description:
  Ceramide very long chain fatty acid hydroxylase scs7; Ceramide hydroxylase involved in the hydroxylation of sphingolipid-associated very long chain fatty acids. Postulated to hydroxylate the very long chain fatty acid of dihydroceramides and phytoceramides at C-2; Belongs to the sterol desaturase family. SCS7 subfamily.


ensembl_gene_id: O13849
symbol: cpy1
gene_biotype: protein_coding
description:
  Carboxypeptidase Y; Involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate; Belongs to the peptidase S10 family.


ensembl_gene_id: O13850
symbol: coq9
gene_biotype: protein_coding
description:
  Ubiquinone biosynthesis protein coq9, mitochondrial; Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.


ensembl_gene_id: O13851
symbol: dlp1
gene_biotype: protein_coding
description:
  Decaprenyl-diphosphate synthase subunit 2; Supplies decaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinones ubiquinone-10.


ensembl_gene_id: O13852
symbol: poz1
gene_biotype: protein_coding
description:
  Protection of telomeres protein poz1; Telomeric DNA-binding protein that negatively regulates telomerase and telomere length.


ensembl_gene_id: O13853
symbol: its3
gene_biotype: protein_coding
description:
  Phosphatidylinositol 4-phosphate 5-kinase its3; Involved, together with the calcineurin ppb1, in cytokinesis.


ensembl_gene_id: O13857
symbol: plb3
gene_biotype: protein_coding
description:
  Putative lysophospholipase SPAC1A6.03c; Catalyzes the release of fatty acids from lysophospholipids. Belongs to the lysophospholipase family.


ensembl_gene_id: O13858
symbol: sle1
gene_biotype: protein_coding
description:
  Eisosome protein sle1; Important for the biogenesis of filamentous eisosomes, large cytoplasmic protein assemblies that localize to specialized domains on the plasma membrane to cluster specific proteins at sites of membrane invaginations.


ensembl_gene_id: O13861
symbol: tcd1
gene_biotype: protein_coding
description:
  tRNA threonylcarbamoyladenosine dehydratase; Catalyzes the ATP-dependent dehydration of threonylcarbamoyladenosine at position 37 (t(6)A37) to form cyclic t(6)A37 (ct(6)A37) in tRNAs that read codons beginning with adenine. Belongs to the HesA/MoeB/ThiF family.


ensembl_gene_id: O13862
symbol: deb1
gene_biotype: protein_coding
description:
  Transcriptional activator protein rdp1; Acts as a DNA damage-response activator of rhp51. Binds to part of the DNA damage-responsive element (DRE), (5'-NG[GT]T[GA]-3').


ensembl_gene_id: O13864
symbol: kap95
gene_biotype: protein_coding
description:
  Importin subunit beta-1; Importin beta subunit that functions in nuclear protein import through association with the importin alpha subunit, which binds to the clasical nuclear localization signal (cNLS) in cargo substrates. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by importin beta through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, GTP-Ran binds to importin beta and the three components separate, lea [...]


ensembl_gene_id: O13865
symbol: pan3
gene_biotype: protein_coding
description:
  PAB-dependent poly(A)-specific ribonuclease subunit pan3-like; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex; Belongs to the protein kinase superfamily. PAN3 family.


ensembl_gene_id: O13867
symbol: SPAC1B3.01c
gene_biotype: protein_coding
description:
  Uracil phosphoribosyltransferase 1; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate.


ensembl_gene_id: O13868
symbol: SPAC1B3.02c
gene_biotype: protein_coding
description:
  Transcription elongation factor 1 homolog; Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions. Belongs to the ELOF1 family.


ensembl_gene_id: O13869
symbol: guf1
gene_biotype: protein_coding
description:
  Translation factor guf1, mitochondrial; Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.


ensembl_gene_id: O13870
symbol: not3
gene_biotype: protein_coding
description:
  General negative regulator of transcription subunit 3; Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery (By similarity). Belongs to the CNOT2/3/5 family.


ensembl_gene_id: O13872
symbol: vps28
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex, a regulator of vesicular trafficking process.


ensembl_gene_id: O13877
symbol: rpb10
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerases I, II, and III subunit RPABC5; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RBP10 is part of the cor [...]


ensembl_gene_id: O13878
symbol: nan1
gene_biotype: protein_coding
description:
  U3 small nucleolar RNA-associated protein 17; Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I together with a subset of U3 proteins required for transcription (t- UTPs) (By similarity).


ensembl_gene_id: O13880
symbol: vht1
gene_biotype: protein_coding
description:
  Vitamin H transporter 1; Involved in uptake of biotin and desthiobiotin with the concomitant entry of protons; Belongs to the major facilitator superfamily. Allantoate permease family.


ensembl_gene_id: O13881
symbol: clr2
gene_biotype: protein_coding
description:
  Cryptic loci regulator 2; Required for deacetylation in the mating-type region and the centromere. Acts upstream of the histone deacetylases to promote transcriptional silencing. Required for proper positioning of nucleosomes at heterochromatic loci and for transcriptional gene silencing (TGS) function of the Snf2/Hdac-containing repressor complex (SHREC).


ensembl_gene_id: O13882
symbol: mrps18
gene_biotype: protein_coding
description:
  Putative 37S ribosomal protein S18, mitochondrial; Belongs to the universal ribosomal protein uS11 family.


ensembl_gene_id: O13883
symbol: gab1
gene_biotype: protein_coding
description:
  GPI transamidase component GAB1 homolog; Component of the GPI transamidase complex. May be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI (By similarity); Belongs to the PIGU family.


ensembl_gene_id: O13889
symbol: hri1
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 2-alpha kinase 1; Mediates down-regulation of protein synthesis in response to stress conditions by the phosphorylation of the alpha subunit of eIF-2 (tif211) on 'Ser-52'. Protein synthesis is inhibited at the level of initiation. Activity is inhibited in the presence of heme.


ensembl_gene_id: O13890
symbol: fmp40
gene_biotype: protein_coding
description:
  Protein adenylyltransferase SelO, mitochondrial; Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Tyr residues of target mitochondrial proteins (AMPylation). Involved in redox homeostasis by regulating the cellular response to oxidative stress. Regulates protein S-glutathionylation levels possibly by AMPylation of deglutathionylation enzymes such as glutaredoxins.


ensembl_gene_id: O13895
symbol: csn4
gene_biotype: protein_coding
description:
  COP9 signalosome complex subunit 4; Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin- protein ligase complexes.


ensembl_gene_id: O13896
symbol: rpc11
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerase III subunit RPC10; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.


ensembl_gene_id: O13898
symbol: ogm1
gene_biotype: protein_coding
description:
  Dolichyl-phosphate-mannose--protein mannosyltransferase 1; Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. Required for normal cell growth and septum formation. Shown to actively O-mannosylate wsc1.


ensembl_gene_id: O13900
symbol: sap114
gene_biotype: protein_coding
description:
  Pre-mRNA-splicing factor sap114; Involved in pre-mRNA splicing. May be involved in endoplasmic reticulum-associated protein degradation (ERAD) and required for growth at low and high temperatures (By similarity).


ensembl_gene_id: O13902
symbol: dak1
gene_biotype: protein_coding
description:
  Dihydroxyacetone kinase 1; Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde; Belongs to the dihydroxyacetone kinase (DAK) family.


ensembl_gene_id: O13903
symbol: rrp40
gene_biotype: protein_coding
description:
  Exosome complex component rrp40; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplas [...]


ensembl_gene_id: O13907
symbol: acl2
gene_biotype: protein_coding
description:
  Probable ATP-citrate synthase subunit 2; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA. Has a central role in de novo lipid synthesis (By similarity); In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.


ensembl_gene_id: O13910
symbol: mpp10
gene_biotype: protein_coding
description:
  U3 small nucleolar ribonucleoprotein protein mpp10; Component of the U3 small nucleolar ribonucleoprotein. Required for the early cleavages at sites A0, A1 and A2 during 18S ribosomal pre-RNA processing (By similarity).


ensembl_gene_id: O13911
symbol: pnk1
gene_biotype: protein_coding
description:
  Bifunctional polynucleotide phosphatase/kinase; Catalyzes the phosphorylation of DNA at 5'-hydroxyl termini and can dephosphorylate its 3'-phosphate termini. Has a role in the repair of breaks in single-stranded DNA; In the N-terminal section; belongs to the DNA 3' phosphatase family.


ensembl_gene_id: O13914
symbol: ala1
gene_biotype: protein_coding
description:
  Alanine--tRNA ligase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family.


ensembl_gene_id: O13915
symbol: mpn1
gene_biotype: protein_coding
description:
  U6 snRNA phosphodiesterase; Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA; Belongs to the 2H phosphoesterase superfamily. USB1 family.


ensembl_gene_id: O13916
symbol: hcn1
gene_biotype: protein_coding
description:
  Anaphase-promoting complex subunit hcn1; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. Has a role in assembling cut9 in the 20S APC/cyclosome.


ensembl_gene_id: O13917
symbol: hpt1
gene_biotype: protein_coding
description:
  Hypoxanthine-guanine phosphoribosyltransferase; Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5- phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity); Belongs to the purine/pyrimidine phosphoribosyltransferase family.


ensembl_gene_id: O13918
symbol: zhf1
gene_biotype: protein_coding
description:
  Zinc homeostasis factor 1; Involved in zinc homeostasis, where it plays a role in its accumulation in the endoplasmic reticulum/nucleus. Also has a role in the sequestration of cadmium into the endoplasmic reticulum. Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.


ensembl_gene_id: O13919
symbol: pst2
gene_biotype: protein_coding
description:
  Paired amphipathic helix protein pst2; Has a role in chromatin assembly and chromosome segregation. Involved in the deacetylation of histones.


ensembl_gene_id: O13920
symbol: mdm28
gene_biotype: protein_coding
description:
  LETM1 domain-containing protein mdm28, mitochondrial; Involved in mitochondrial potassium homeostasis through the mitochondrial K(+)/H(+) exchange regulation.


ensembl_gene_id: O13921
symbol: msh1
gene_biotype: protein_coding
description:
  MutS protein homolog 1; Involved in mitochondrial DNA repair; Belongs to the DNA mismatch repair MutS family.


ensembl_gene_id: O13924
symbol: hrk1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase haspin homolog hrk1; Serine/threonine haspin-like protein kinase involved in cell cycle regulation. Acts in chromosomal passenger complex (CPC) targeting to centromeres by phosphorylating histone H3 at 'Thr3' (H3T3ph).


ensembl_gene_id: O13928
symbol: rho3
gene_biotype: protein_coding
description:
  GTP-binding protein rho3; Involved in controlling cell shape and septation. Regulates cell separation by modulating the function of the exocyst complex. Involved in post-Golgi vesicle transport.


ensembl_gene_id: O13930
symbol: sec2
gene_biotype: protein_coding
description:
  Rab guanine nucleotide exchange factor sec2; Guanyl-nucleotide exchange factor for ypt2. Catalyzing the dissociation of GDP from ypt2 and promotes the binding of GTP (By similarity).


ensembl_gene_id: O13931
symbol: atp18
gene_biotype: protein_coding
description:
  ATP synthase subunit J, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the centr [...]


ensembl_gene_id: O13932
symbol: bet1
gene_biotype: protein_coding
description:
  Protein transport protein bet1; SNARE required for targeting and fusion of ER-derived transport vesicles with the Golgi complex.


ensembl_gene_id: O13933
symbol: alg1
gene_biotype: protein_coding
description:
  Chitobiosyldiphosphodolichol beta-mannosyltransferase; Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER (By similarity); Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 33 subfamily.


ensembl_gene_id: O13934
symbol: atg15
gene_biotype: protein_coding
description:
  Putative lipase atg15; Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by atg15 is critical to life span extension (By similarity).


ensembl_gene_id: O13935
symbol: trm402
gene_biotype: protein_coding
description:
  Multisite-specific tRNA:(cytosine-C(5))-methyltransferase trm4b; tRNA cytosine C(5)-methyltransferase that methylates cytosine to 5-methylcytosine (m5C) in tRNAs at position 49 and 50. Trm4a and trm4b methylate different sets of tRNAs. Also methylates cytosine to m5C at positions (60, 61 and 62) in tRNA(Asp) ; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. TRM4 subfamily.


ensembl_gene_id: O13936
symbol: spt5
gene_biotype: protein_coding
description:
  Transcription elongation factor spt5; The spt4-spt5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (By similarity).


ensembl_gene_id: O13939
symbol: apl6
gene_biotype: protein_coding
description:
  AP-3 complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Beta adaptin is a subunit of the plasma membrane adaptor (By similarity).


ensembl_gene_id: O13941
symbol: SPAC23H3.11c
gene_biotype: protein_coding
description:
  Uncharacterized beta-glucan synthesis-associated protein C23H3.11c; Required for synthesis of the major beta-glucans of the yeast cell wall; Belongs to the SKN1/KRE6 family.


ensembl_gene_id: O13943
symbol: avl9
gene_biotype: protein_coding
description:
  Late secretory pathway protein avl9; Functions in the late secretory pathway. Required for the generation of secretory vesicles as well as for actin polarization and polarized growth (By similarity); Belongs to the AVL9 family.


ensembl_gene_id: O13946
symbol: erv25
gene_biotype: protein_coding
description:
  Endoplasmic reticulum vesicle protein 25; Constituent of COPII-coated endoplasmic reticulum-derived transport vesicles. Required for efficient transport of a subset of secretory proteins to the Golgi. Facilitates retrograde transport from the Golgi to the endoplasmic reticulum (By similarity); Belongs to the EMP24/GP25L family.


ensembl_gene_id: O13947
symbol: slm3
gene_biotype: protein_coding
description:
  Mitochondrial tRNA-specific 2-thiouridylase 1; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base. Belongs to the MnmA/TRMU family.


ensembl_gene_id: O13950
symbol: srp102
gene_biotype: protein_coding
description:
  Signal recognition particle receptor subunit beta; Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system. Has GTPase activity. May mediate the membrane association of SRPR (By similarity).


ensembl_gene_id: O13952
symbol: cnl2
gene_biotype: protein_coding
description:
  Inner kinetochore subunit cnl2; Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.


ensembl_gene_id: O13953
symbol: alp13
gene_biotype: protein_coding
description:
  Chromatin modification-related protein eaf3; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). Also involved in deacetylation of histones, chromatin assembly and chromosome segregation. May act as a transcriptional oscillator, directing histone deacetylases to specific chromosomal domains; Belongs to the MRG family.


ensembl_gene_id: O13955
symbol: vam6
gene_biotype: protein_coding
description:
  Vacuolar morphogenesis protein 6; Required for vacuolar assembly. Acts as component of the HOPS complex that acts during the docking stage of vacuole fusion. HOPS is required for vacuolar SNARE complex assembly. It remains bound to SNARE complexes after vacuole fusion (By similarity).


ensembl_gene_id: O13956
symbol: tsr1
gene_biotype: protein_coding
description:
  Ribosome biogenesis protein tsr1; Required for 40S ribosomal subunit synthesis. Required for normal export of the pre-40S particles from the nucleus to the cytoplasm (By similarity); Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. TSR1 subfamily.


ensembl_gene_id: O13958
symbol: srb10
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase srb10; Catalytic component of the Cdk8 module/Srb8-11 module which is a regulatory module of the Mediator complex that regulates basal RNA polymerase II transcription. The Cdk8 module may sterically hinder the interaction between Mediator and RNA polymerase II leading to transcriptional repression of a subset of genes regulated by Mediator. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.


ensembl_gene_id: O13959
symbol: rbx1
gene_biotype: protein_coding
description:
  RING-box protein pip1; Component of E3 ubiquitin ligase SCF complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recruit the E2 ubiquitination enzyme, like UBC3/CDC34, to the complex and brings it into close proximity to the substrate. Component of the rik1-associated E3 ubiquitin ligase complex that shows ubiquitin ligase activity and is required for histone H3K9 methylation. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting swi6/HP1 to methylated histones which leads to transcriptional s [...]


ensembl_gene_id: O13960
symbol: ecm33
gene_biotype: protein_coding
description:
  Cell wall protein ecm33; Involved in the negative feedback regulation of pmk1 cell integrity signaling and is linked to cellular calcium signaling.


ensembl_gene_id: O13961
symbol: cut11
gene_biotype: protein_coding
description:
  Nuclear envelope protein ndc1; Component of the nuclear pore complex (NPC) and the spindle pole body (SPB), which plays a key role in de novo assembly and insertion of both structures in the nuclear envelope. Involved in the formation of the bipolar mitotic spindle. Anchors the spindle pole body in the nuclear envelope; Belongs to the NDC1 family.


ensembl_gene_id: O13962
symbol: cyt2
gene_biotype: protein_coding
description:
  Putative cytochrome c1 heme lyase; Involved in the final maturation of cytochrome c1, it links covalently the heme group to the apoprotein.


ensembl_gene_id: O13966
symbol: aco1
gene_biotype: protein_coding
description:
  Aconitate hydratase, mitochondrial; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate, a step in the citric acid cycle; Belongs to the aconitase/IPM isomerase family.


ensembl_gene_id: O13967
symbol: bgs2
gene_biotype: protein_coding
description:
  1,3-beta-glucan synthase component bgs2; Has a role in ascospore development where it is required for the assembly of a functional spore wall; Belongs to the glycosyltransferase 48 family.


ensembl_gene_id: O13969
symbol: SPAC24C9.09
gene_biotype: protein_coding
description:
  Probable threonine--tRNA ligase, mitochondrial; Belongs to the class-II aminoacyl-tRNA synthetase family.


ensembl_gene_id: O13971
symbol: sgd1
gene_biotype: protein_coding
description:
  Suppressor of glycerol defect protein 1; Involved in osmoregulatory glycerol response; Belongs to the CWC22 family.


ensembl_gene_id: O13972
symbol: shm1
gene_biotype: protein_coding
description:
  Probable serine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine; Belongs to the SHMT family.


ensembl_gene_id: O13973
symbol: mrp10
gene_biotype: protein_coding
description:
  37S ribosomal protein mrp10, mitochondrial; Involved in mitochondrial genome encoded proteins translation.


ensembl_gene_id: O13974
symbol: otu1
gene_biotype: protein_coding
description:
  Putative ubiquitin thioesterase otu1; Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation (By similarity). Has a role in meiosis.


ensembl_gene_id: O13978
symbol: atg101
gene_biotype: protein_coding
description:
  Meiotically up-regulated gene 66 protein; Autophagy factor required for autophagosome formation (By similarity). Has a role in meiosis and sporulation; Belongs to the ATG101 family.


ensembl_gene_id: O13979
symbol: mug105
gene_biotype: protein_coding
description:
  Ubiquitin carboxyl-terminal hydrolase mug105; Deubiquitinase with endodeubiquitinase activity that preferentially cleaves 'Lys-48'-linked polyubiquitin chains. Shows only weak activity against 'Lys-63' and 'Lys-11'-linked chains. Has a role in meiosis ; Belongs to the peptidase C78 family. ZUFSP subfamily.


ensembl_gene_id: O13981
symbol: emc1
gene_biotype: protein_coding
description:
  ER membrane protein complex subunit 1; The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER).


ensembl_gene_id: O13983
symbol: hrq1
gene_biotype: protein_coding
description:
  ATP-dependent helicase hrq1; Helicase with 3'-5' helicase activity involved in genome stability. Functions in the nucleotide excision repair (NER) pathway and plays a critical role in DNA interstrand cross-link repair. Unwinds relatively long duplex DNA up to 120-bp and requires a long 3'-tail of at least 70 nucleotides for efficient unwinding of duplex DNA (By similarity). Shows both processive helicase and DNA strand annealing activities (By similarity). Affects telomere length by a non-catalytic mechanism, probably through inhibiting telomerase by competing with it for ssDNA binding [...]


ensembl_gene_id: O13984
symbol: mgs1
gene_biotype: protein_coding
description:
  ATPase WRNIP1 homolog C26H5.02c; Functions as a modulator for initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. Has an intrinsic ATPase activity that functions as a sensor of DNA damage or of arrested replication forks and regulates the extent of DNA synthesis (By similarity); Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.


ensembl_gene_id: O13988
symbol: pot1
gene_biotype: protein_coding
description:
  Protection of telomeres protein 1; Single-stranded telomeric DNA-binding protein that is required to protect the 3'-end telomeric overhang. It binds the consensus sequence 5'-GGTTAC-3'. Regulates telomerase and telomere length.


ensembl_gene_id: O13990
symbol: bgl2
gene_biotype: protein_coding
description:
  Glucan 1,3-beta-glucosidase; Glucanases possibly play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation and also function biosynthetically as a transglycosylase.


ensembl_gene_id: O13993
symbol: rpo41
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerase, mitochondrial; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Combines in the mitochondrion with mitochondrial transcription factor mtf1 as a holoenzyme to recognize and initiate transcription at the core mitochondrial promoters.


ensembl_gene_id: O13994
symbol: kei1
gene_biotype: protein_coding
description:
  Inositol phosphorylceramide synthase regulatory subunit kei1; Regulatory component of the inositol phosphorylceramide (ICP) synthase which catalyzes the addition of a phosphorylinositol group onto ceramide to form inositol phosphorylceramide, an essential step in sphingolipid biosynthesis. Helps the medial Golgi localization of IPC synthase in a COPI vesicle-dependent manner (By similarity).


ensembl_gene_id: O13995
symbol: dap1
gene_biotype: protein_coding
description:
  Cytochrome P450 regulator dap1; Required for sterol biosynthesis. Functions as a positive regulator of cytochrome P450 enzymes erg5 and erg11. Function requires bound heme; Belongs to the cytochrome b5 family. MAPR subfamily.


ensembl_gene_id: O13997
symbol: yih1
gene_biotype: protein_coding
description:
  Protein IMPACT homolog; Translational regulator that ensures constant high levels of translation under amino acid starvation. Plays a role as a negative regulator of the gcn2 kinase activity; impairs gcn1-mediated gcn2 activation, and hence gcn2-mediated eIF-2-alpha phosphorylation in amino acid-starved cells and subsequent down-regulation of protein synthesis. In normal conditions, it resides in a actin complex and has no activity.


ensembl_gene_id: O13998
symbol: SPAC27E2.03c
gene_biotype: protein_coding
description:
  Obg-like ATPase 1; Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP (By similarity). Negatively regulates the G2/M transition in the cell cycle; Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.


ensembl_gene_id: O14000
symbol: msm1
gene_biotype: protein_coding
description:
  Probable methionine--tRNA ligase, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family.


ensembl_gene_id: O14001
symbol: pvg2
gene_biotype: protein_coding
description:
  Pyruvylated Gal-beta-1,3-epitope synthesis protein 2; Involved in cell wall biogenesis. Has a role in the addition of Gal-beta1,3 moeities to galactomannans and their subsequent pyruvylation. Has a role in meiosis.


ensembl_gene_id: O14002
symbol: mak2
gene_biotype: protein_coding
description:
  Peroxide stress-activated histidine kinase mak2; Involved in the control of the SAPK-dependent transcriptional response to peroxide stress. Regulates sty1 activity.


ensembl_gene_id: O14003
symbol: rfc3
gene_biotype: protein_coding
description:
  Replication factor C subunit 3; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. Subunit 3 binds ATP. Also involved in replication and DNA damage checkpoint controls, probably functioning as a checkpoint sensor.


ensembl_gene_id: O14007
symbol: cbf5
gene_biotype: protein_coding
description:
  H/ACA ribonucleoprotein complex subunit cbf5; Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs and play a central role in ribosomal RNA processing. The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs. Catalyzes pseudouridylation at position 93 in U2 snRNA. Also catalyzes pseudouridy [...]


ensembl_gene_id: O14010
symbol: srb6
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 22; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.


ensembl_gene_id: O14011
symbol: prp19
gene_biotype: protein_coding
description:
  Pre-mRNA-processing factor 19; Probable ubiquitin-protein ligase involved in pre-mRNA splicing where it associates with cdc5 and the other cwf proteins as part of the spliceosome. May also function in DNA repair. Belongs to the WD repeat PRP19 family.


ensembl_gene_id: O14012
symbol: rrp17
gene_biotype: protein_coding
description:
  Ribosomal RNA-processing protein 17; Involved in ribosomal RNA processing; Belongs to the RRP17 family.


ensembl_gene_id: O14013
symbol: rrn5
gene_biotype: protein_coding
description:
  RNA polymerase I-specific transcription initiation factor rrn5; Component of the UAF (upstream activation factor) complex which interacts with the upstream element of the RNA polymerase I promoter and forms a stable preinitiation complex. UAF seems to stimulate basal transcription to a fully activated level.


ensembl_gene_id: O14016
symbol: ure6
gene_biotype: protein_coding
description:
  Uncharacterized urease accessory protein UreF-like; Probably facilitates nickel incorporation; Belongs to the UreF family.


ensembl_gene_id: O14018
symbol: srs1
gene_biotype: protein_coding
description:
  Serine--tRNA ligase, cytoplasmic; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec) (By similarity).


ensembl_gene_id: O14019
symbol: hal4
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase hal4; Promotes K(+) uptake, by the potassium transporter trk1-trk2, which leads to the subsequent cellular resistance to toxic cations such as Na(+), Li(+) and Ca(2+).


ensembl_gene_id: O14021
symbol: prw1
gene_biotype: protein_coding
description:
  RbAp48-related WD40 repeat-containing protein prw1; Has a role in chromatin assembly and chromosome segregation. Involved in the deacetylation of histones. Belongs to the WD repeat HIR1 family.


ensembl_gene_id: O14022
symbol: cta5
gene_biotype: protein_coding
description:
  Cation-transporting ATPase 5; Plays a role in regulating calcium and manganese homeostasis responsible for cell cycle progression.


ensembl_gene_id: O14023
symbol: elp3
gene_biotype: protein_coding
description:
  Elongator complex protein 3; Catalytic subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation (By similarity). The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5- methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). Elp3 acts as a tRNA uridine(34) acetyltransferase, which mediates formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity).


ensembl_gene_id: O14026
symbol: set2
gene_biotype: protein_coding
description:
  Histone-lysine N-methyltransferase, H3 lysine-36 specific; Histone methyltransferase that trimethylates histone H3 'Lys- 36' forming H3K36me3 (By similarity). Involved in transcription elongation as well as in transcription repression. Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.


ensembl_gene_id: O14027
symbol: snz1
gene_biotype: protein_coding
description:
  Probable pyridoxal 5'-phosphate synthase subunit PDX1; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by PDX2. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme- catalyzed isomerization of RBP and G3P, respectively. Also plays an indirect role in resistance to singlet oxygen-generating photosensitizers.


ensembl_gene_id: O14028
symbol: mtq1
gene_biotype: protein_coding
description:
  Probable MRF1 mitochondrial N(5)-glutamine methyltransferase mtq1; Methylates MRF1 on 'Gln-270' using S-adenosyl L-methionine as methyl donor.


ensembl_gene_id: O14029
symbol: sec16
gene_biotype: protein_coding
description:
  COPII coat assembly protein sec16; Involved in the initiation of assembly of the COPII coat required for the formation of transport vesicles from the endoplasmic reticulum (ER) and the selection of cargo molecules. Also involved in autophagy (By similarity).


ensembl_gene_id: O14031
symbol: pgt1
gene_biotype: protein_coding
description:
  Glutathione transporter 1; High-affinity glutathione transporter which plays a role in scavenging glutathione from the extracellular environment for the maintenance of sulfur homeostasis; Belongs to the oligopeptide OPT transporter family.


ensembl_gene_id: O14036
symbol: smd2
gene_biotype: protein_coding
description:
  Small nuclear ribonucleoprotein Sm D2; Involved in pre-mRNA splicing. Binds snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site (By similarity).


ensembl_gene_id: O14039
symbol: rcm1
gene_biotype: protein_coding
description:
  25S rRNA (cytosine-C(5))-methyltransferase rcm1; S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of a cytosine in 25S rRNA. Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.


ensembl_gene_id: O14040
symbol: dis32
gene_biotype: protein_coding
description:
  DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'.


ensembl_gene_id: O14044
symbol: pno1
gene_biotype: protein_coding
description:
  Pre-rRNA-processing protein pno1; Required for small ribosomal subunit (SSU) synthesis. Has a role in the processing of early nucleolar and late cytoplasmic pre-RNA species.


ensembl_gene_id: O14045
symbol: tpt1
gene_biotype: protein_coding
description:
  Putative tRNA 2'-phosphotransferase; Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP- ribose 1''-2'' cyclic phosphate; Belongs to the KptA/TPT1 family.


ensembl_gene_id: O14046
symbol: vma16
gene_biotype: protein_coding
description:
  Probable V-type proton ATPase 20 kDa proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells (By similarity).


ensembl_gene_id: O14048
symbol: ubx2
gene_biotype: protein_coding
description:
  UBX domain-containing protein 2; Involved in CDC48-dependent protein degradation through the ubiquitin/proteasome pathway.


ensembl_gene_id: O14050
symbol: msy2
gene_biotype: protein_coding
description:
  Mechanosensitive ion channel protein Msy2; Regulates intracellular calcium levels and cell volume for survival in response to hypo-osmotic shock. Involved in maintaining vacuole integrity and protecting the nuclear envelope upon hypo-osmotic shock.


ensembl_gene_id: O14053
symbol: utp21
gene_biotype: protein_coding
description:
  U3 small nucleolar RNA-associated protein 21 homolog; Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.


ensembl_gene_id: O14055
symbol: yrs1
gene_biotype: protein_coding
description:
  Tyrosine--tRNA ligase, cytoplasmic; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).


ensembl_gene_id: O14056
symbol: cox19
gene_biotype: protein_coding
description:
  Cytochrome c oxidase assembly protein cox19, mitochondrial; Required for the assembly of mitochondrial cytochrome c oxidase; Belongs to the COX19 family.


ensembl_gene_id: O14057
symbol: gud1
gene_biotype: protein_coding
description:
  Probable guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.


ensembl_gene_id: O14063
symbol: cut15
gene_biotype: protein_coding
description:
  Importin subunit alpha-1; Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Promotes docking of import substrates to the nuclear envelope. Seems to act as a cytosolic receptor for both simple and bipartite NLS motifs. Has an essential role in mitotic chromosome condensation. Involved in nuclear protein import. Required for efficient nuclear import of both an SV40 nuclear localization signal-containing reporter protein and the pap1 component of the stress response MAP kinase pathway. Required for proper mitotic progression.


ensembl_gene_id: O14064
symbol: bir1
gene_biotype: protein_coding
description:
  Protein bir1; Seems to act in the pleiotropic control of cell division. Has a role in chromosome segregation by recruiting condensin and ark1 kinase to appropriate sites as the cell progresses through mitosis. Ark1 activity depends upon bir1 function and phosphorylation. Ark1 with bir1 function is required for full-scale association with kinetochores and formation of a complex with mad3.


ensembl_gene_id: O14066
symbol: irs4
gene_biotype: protein_coding
description:
  Increased rDNA silencing protein 4 homolog; Positive regulator of phosphatidylinositol 4,5-bisphosphate turnover and negatively regulates signaling through the cell integrity pathway. Involved in rDNA silencing (By similarity).


ensembl_gene_id: O14072
symbol: cta4
gene_biotype: protein_coding
description:
  Manganese-transporting ATPase 4; Mediates manganese transport into the endoplasmic reticulum. The ATPase activity is required for cellular manganese homeostasis (By similarity). Involved in controlling nuclear calcium ion levels. Required for cytokinesis and stabilizing microtubules.


ensembl_gene_id: O14075
symbol: gor1
gene_biotype: protein_coding
description:
  Putative 2-hydroxyacid dehydrogenase UNK4.10; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.


ensembl_gene_id: O14078
symbol: SPACUNK4.13c
gene_biotype: protein_coding
description:
  Obg-like ATPase homolog; Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP (By similarity).


ensembl_gene_id: O14079
symbol: mdb1
gene_biotype: protein_coding
description:
  DNA damage response protein Mdb1; Involved in DNA damage response (DDR) mediated through its interaction with phosphorylated H2A proteins hta1 and hta2 which mark the discrete foci of DNA damage.


ensembl_gene_id: O14084
symbol: imt1
gene_biotype: protein_coding
description:
  Inositol phosphoceramide mannosyltransferase 1; With imt2 and imt3, is required for the synthesis of mannosyl phosphorylinositol ceramide (MIPC). Catalyzes the addition of mannosyl to phosphorylinositol ceramide (IPC). MIPC is essential for cell morphology, cell-surface distribution of ergosterol, localization for plasma-membrane transporters, and lipid-raft-mediated endocytosis of plasma membrane proteins to the vacuole; Belongs to the glycosyltransferase 32 family.


ensembl_gene_id: O14085
symbol: sec67
gene_biotype: protein_coding
description:
  Translocation protein sec72; Acts as non-essential component of the Sec62/63 complex which is involved in SRP-independent post-translational translocation across the endoplasmic reticulum (ER) and functions together with the Sec61 complex and bip1 in a channel-forming translocon complex. A cycle of assembly and disassembly of Sec62/63 complex from sec61 may govern the activity of the translocon. sec72 may be involved in signal peptide recognition for a defined subset of leader peptides, or may increase the efficiency of unusual or 'difficult' secretory precursors to the translocation p [...]


ensembl_gene_id: O14086
symbol: rpa49
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerase I subunit rpa49; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors.


ensembl_gene_id: O14087
symbol: rim1
gene_biotype: protein_coding
description:
  Single-stranded DNA-binding protein rim1, mitochondrial; This protein binds preferentially and cooperatively to ss- DNA. Involved in mitochondrial DNA replication (By similarity).


ensembl_gene_id: O14089
symbol: kap104
gene_biotype: protein_coding
description:
  Importin subunit beta-2; Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for arginine/glycine-rich nuclear localization signals (rg-NLS) and PY-NLS in cargo substrates. Its predominant cargo substrate seems to be mRNA-binding proteins. Mediates docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to repeat-containing nucleoporins. The complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, GTP-Ran binding leads to release of  [...]


ensembl_gene_id: O14091
symbol: sut1
gene_biotype: protein_coding
description:
  General alpha-glucoside permease; Responsible for the transport of maltose and sucrose into the cell, with the concomitant uptake of protons (symport system). Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2.4) family.


ensembl_gene_id: O14092
symbol: hem1
gene_biotype: protein_coding
description:
  5-aminolevulinate synthase, mitochondrial; Catalyzes the synthesis of 5-aminolevulinate (ALA) from succinyl-CoA and glycine, the first and rate-limiting step in heme biosynthesis.


ensembl_gene_id: O14093
symbol: vps54
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 54; Involved in retrograde transport from early and late endosomes to late Golgi by linking the vesicle through the t-SNARE TGL1 to the Golgi, leading to the membrane fusion between late Golgi and endosomal vesicles. Seems also to be involved in protein transport from Golgi to the plasma membrane and is required for the integrity of the actin cytoskeleton (By similarity).


ensembl_gene_id: O14095
symbol: plp1
gene_biotype: protein_coding
description:
  Thioredoxin domain-containing protein plp1; Inhibits early G-protein signaling events following pheromone stimulation. May help create heterodimerizable beta-tubulin by facilitating the efficient transfer of nascent beta-tubulin polypeptides to the folding apparatus (By similarity); Belongs to the phosducin family.


ensembl_gene_id: O14096
symbol: qtr2
gene_biotype: protein_coding
description:
  Queuine tRNA-ribosyltransferase accessory subunit 2; Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine); Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.


ensembl_gene_id: O14098
symbol: lsk1
gene_biotype: protein_coding
description:
  CTD kinase subunit alpha; Catalytic subunit of the CTDK-I complex, which hyperphosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit. Involved in RNA polymerase II transcriptional elongation and pre-mRNA 3'-end processing (By similarity). Together with ctk2/lsc1, required for the regulation of cytokinesis by phosphorylating 'Ser-2' residues found in the heptad repeats of the CTD. Required for nuclear localization of ctk2/lsc1. Positively regulates the septation initiation network (SIN) and promotes successful completion of cytokinesis in [...]


ensembl_gene_id: O14100
symbol: zds1
gene_biotype: protein_coding
description:
  Protein zds1; Has a role in establishing cell polarity. Also required for maintenance of cell wall integrity, sexual differentiation, calcium tolerance and cell morphology. Involved in Ras-MAPK signaling pathway at cell cortex. Has a role in meiosis.


ensembl_gene_id: O14103
symbol: rot1
gene_biotype: protein_coding
description:
  Protein rot1; Required for normal levels of the cell wall 1,6-beta-glucan. Involved in a protein folding machinery chaperoning proteins acting in various physiological processes including cell wall synthesis and lysis of autophagic bodies (By similarity); Belongs to the ROT1 family.


ensembl_gene_id: O14105
symbol: rpe1
gene_biotype: protein_coding
description:
  Ribulose-phosphate 3-epimerase; Catalyzes the reversible epimerization of D-ribulose 5- phosphate to D-xylulose 5-phosphate; Belongs to the ribulose-phosphate 3-epimerase family.


ensembl_gene_id: O14107
symbol: dni1
gene_biotype: protein_coding
description:
  Cell fusion protein dni1; Cell membrane protein which plays a relevant role in coordinating membrane organization and cell wall remodeling during mating; Belongs to the SUR7 family.


ensembl_gene_id: O14109
symbol: maf1
gene_biotype: protein_coding
description:
  Repressor of RNA polymerase III transcription maf1; Mediator of diverse signals that repress RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA.


ensembl_gene_id: O14110
symbol: gcv1
gene_biotype: protein_coding
description:
  Probable aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.


ensembl_gene_id: O14111
symbol: psd3
gene_biotype: protein_coding
description:
  Phosphatidylserine decarboxylase 3 alpha chain; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine (By similarity). Together with psd1 and psd2, responsible for the majority of phosphatidylethanolamine synthesis. Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type II sub-subfamily.


ensembl_gene_id: O14113
symbol: sde2
gene_biotype: protein_coding
description:
  Telomere maintenance protein SDE2; Plays a role in the regulation of telomeric and centromeric silencing. Contributes to the prevention of abnormal telomere elongation. Required for chromosome segregation to daughter cells in mitosis and meiosis. May participate in the recruitment of the histone deacetylase silencing complex SHREC, which prevents transcription at telomeres; Belongs to the SDE2 family.


ensembl_gene_id: O14115
symbol: ptl2
gene_biotype: protein_coding
description:
  Patatin-like phospholipase domain-containing protein SPAC1786.01c; Probable lipid hydrolase; Belongs to the PLPL family.


ensembl_gene_id: O14118
symbol: efm3
gene_biotype: protein_coding
description:
  Protein-lysine N-methyltransferase efm3; S-adenosyl-L-methionine-dependent protein-lysine N- methyltransferase that methylates elongation factor 2. Belongs to the class I-like SAM-binding methyltransferase superfamily. EEF2KMT family.


ensembl_gene_id: O14119
symbol: sei1
gene_biotype: protein_coding
description:
  Seipin homolog; Involved in lipid metabolism and lipid droplet (LD) morphology, number, and size. Facilitates initiation of LD formation, and ensures that vectorial budding of LDs from the ER is directed towards the cytoplasm; Belongs to the seipin family.


ensembl_gene_id: O14122
symbol: cul4
gene_biotype: protein_coding
description:
  Cullin-4; Required, indirectly, for activation of ribonucleotide reductase through the degradation of the protein spd1, thereby supplying deoxyribonucleotides for DNA replication and repair. Also has a role as a scaffold for assembling ubiquitin ligases. Component of the rik1-associated E3 ubiquitin ligase complex that shows ubiquitin ligase activity and is required for histone H3K9 methylation. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting swi6/HP1 to methylated histones which leads to transcriptional silencing within centromeric heterochroma [...]


ensembl_gene_id: O14123
symbol: sod22
gene_biotype: protein_coding
description:
  Probable Na(+)/H(+) antiporter C3A11.09; Sodium export from cell, takes up external protons in exchange for internal sodium ions; Belongs to the fungal Na(+)/H(+) exchanger family.


ensembl_gene_id: O14126
symbol: rpt5
gene_biotype: protein_coding
description:
  26S proteasome regulatory subunit 6A; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).


ensembl_gene_id: O14128
symbol: pil2
gene_biotype: protein_coding
description:
  Probable sphingolipid long chain base-responsive protein pil2; Negative regulator of cell wall integrity (CWI) in unstressed cells, probably by inhibiting protein kinase ksg1/ppk21 activity and regulating their downstream CWI pathways pck2-MAP kinase pathway and protein kinase gad8 pathway. Activity may be regulated by the transient increase of sphingolipid long chain bases (LCBs) during heat stress (By similarity).


ensembl_gene_id: O14129
symbol: rad55
gene_biotype: protein_coding
description:
  DNA repair protein rhp55; Required for radiation resistance and meiotic viability and acts in recombination and recombinational DNA repair pathways.


ensembl_gene_id: O14133
symbol: ate1
gene_biotype: protein_coding
description:
  Arginyl-tRNA--protein transferase 1; Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Does not arginylate cysteine residues (By similarity).


ensembl_gene_id: O14134
symbol: elf1
gene_biotype: protein_coding
description:
  mRNA export factor elf1; Has a direct role in the mRNA export process. Appears to act within the rae1 mediated mRNA export pathway. Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.


ensembl_gene_id: O14136
symbol: pex13
gene_biotype: protein_coding
description:
  Peroxisomal membrane protein pex13; Component of the peroxisomal translocation machinery with pex14 and pex17; Belongs to the peroxin-13 family.


ensembl_gene_id: O14137
symbol: SPAC3C7.13c
gene_biotype: protein_coding
description:
  Probable glucose-6-phosphate 1-dehydrogenase C7.13c; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis (By similarity); Belongs to the glucose-6-phosphate dehydrogenase family.


ensembl_gene_id: O14138
symbol: SPAC25A8.03c
gene_biotype: protein_coding
description:
  Protein arginine methyltransferase NDUFAF7 homolog, mitochondrial; Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).


ensembl_gene_id: O14139
symbol: hrp3
gene_biotype: protein_coding
description:
  Chromodomain helicase hrp3; Involved in heterochromatin silencing. Required for transcriptional repression at the silence loci of mat3, where it has a direct role as a chromatin remodeling factor.


ensembl_gene_id: O14140
symbol: rpn15
gene_biotype: protein_coding
description:
  26S proteasome complex subunit rpn15; Versatile protein that might stabilize multiple protein complexes involved in diverse pathways. Subunit of the 26S proteasome which plays a role in ubiquitin-dependent proteolysis. Acts as a ubiquitin receptor of the 26S proteasome, by interacting with ubiquitin chains linked by 'Lys-63' and 'Lys-48'. Involved in nuclear export of specific sets of mRNAs. Links the mRNA adapter mlo3 to rae1 for targeting mRNA-protein complex to the proteins of the nucleoporin complex (NPC). Involved in recombinational repair of DNA. Plays a critical role in linking  [...]


ensembl_gene_id: O14141
symbol: SPAC3G6.03c
gene_biotype: protein_coding
description:
  dTTP/UTP pyrophosphatase; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.


ensembl_gene_id: O14144
symbol: erv1
gene_biotype: protein_coding
description:
  Mitochondrial FAD-linked sulfhydryl oxidase erv1; FAD-dependent sulfhydryl oxidase that catalyzes disulfide bond formation. Required for the import and folding of small cysteine- containing proteins in the mitochondrial intermembrane space (IMS) (By similarity).


ensembl_gene_id: O14145
symbol: tps2
gene_biotype: protein_coding
description:
  Trehalose-phosphatase; Phosphatase catalytic subunit of the trehalose synthase complex that catalyzes the production of trehalose from glucose-6- phosphate and UDP-glucose in a two step process; In the N-terminal section; belongs to the glycosyltransferase 20 family.


ensembl_gene_id: O14146
symbol: vps51
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 51; Involved in retrograde transport from early and late endosomes to late Golgi, leading to the membrane fusion between late Golgi and endosomal vesicles.


ensembl_gene_id: O14147
symbol: chl1
gene_biotype: protein_coding
description:
  ATP-dependent DNA helicase chl1; ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G(2)/M (By similarity). May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres (By similarity). Has a specific role in chromosome segregation during meiosis II (By similarity).


ensembl_gene_id: O14148
symbol: ino80
gene_biotype: protein_coding
description:
  Chromatin-remodeling ATPase INO80; ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.


ensembl_gene_id: O14157
symbol: myp2
gene_biotype: protein_coding
description:
  Myosin type-2 heavy chain 2; Stabilizes the F-actin cables forming the F-actin ring that surrounds the nucleus during interphase. May work in conjunction with myo2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.


ensembl_gene_id: O14159
symbol: lcb4
gene_biotype: protein_coding
description:
  Sphingoid long chain base kinase 4; Catalyzes the phosphorylation of the sphingoid long chain bases dihydrosphingosine (DHS) and phytosphingosine (PHS) to form dihydrosphingosine 1-phosphate (DHS-1P) and phytosphingosine 1- phosphate (PHS-1P) respectively (By similarity). Involved in the biosynthesis of sphingolipids and ceramides (By similarity). Involved in heat-induced transient cell cycle arrest (By similarity). Accumulation of phosphorylated sphingoid long chain bases (LCBPs) stimulates calcium influx and activates calcineurin signaling. Involved in heat-stress resistance (By simi [...]


ensembl_gene_id: O14161
symbol: cwf21
gene_biotype: protein_coding
description:
  Pre-mRNA-splicing factor cwf21; Involved in pre-mRNA splicing. May function at or prior to the first catalytic step of splicing at the catalytic center of the spliceosome. May do so by stabilizing the catalytic center or the position of the RNA substrate (By similarity).


ensembl_gene_id: O14164
symbol: tif303
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 3 subunit C; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.


ensembl_gene_id: O14165
symbol: pud1
gene_biotype: protein_coding
description:
  Uncharacterized protein C4C5.01; Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.


ensembl_gene_id: O14169
symbol: pgc1
gene_biotype: protein_coding
description:
  Phosphatidylglycerol phospholipase C; Phosphatidylglycerol phospholipase required for the removal of excess phosphatidylglycerol (PG) via a phospholipase C-type degradation mechanism; Belongs to the glycerophosphoryl diester phosphodiesterase family.


ensembl_gene_id: O14170
symbol: pop2
gene_biotype: protein_coding
description:
  WD repeat-containing protein pop2; Involved in maintenance of ploidy through proteasome dependent degradation of CDK inhibitor rum1 and S-phase initiator cdc18. Functions as a recognition factor for rum1 and cdc18, which are subsequently ubiquitinated and targeted to the 26S proteasome for degradation. Together with pop1, required for cig2 instability during G2 and M phase and cig2 degradation in exponentially growing cells.


ensembl_gene_id: O14171
symbol: rer2
gene_biotype: protein_coding
description:
  Dehydrodolichyl diphosphate synthase complex subunit SPAC4D7.04c; With nus1, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Adds multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER).


ensembl_gene_id: O14172
symbol: met8
gene_biotype: protein_coding
description:
  Siroheme biosynthesis protein met8; Catalyzes the conversion of precorrin-2 into siroheme. This reaction consist of the NAD-dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity); Belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. MET8 subfamily.


ensembl_gene_id: O14174
symbol: spt20
gene_biotype: protein_coding
description:
  SAGA complex subunit spt20; Functions as component of the transcription regulatory histone acetylation (HAT) complex SAGA. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DN [...]


ensembl_gene_id: O14175
symbol: dsc4
gene_biotype: protein_coding
description:
  DSC E3 ubiquitin ligase complex subunit 4; Component of the DSC E3 ubiquitin ligase complex which is required for the sre1 transcriptional activator proteolytic cleavage to release the soluble transcription factor from the membrane in low oxygen or sterol conditions. The complex plays also an important role in the multivesicular body (MVB) pathway and functions in a post- endoplasmic reticulum pathway for protein degradation.


ensembl_gene_id: O14176
symbol: usp104
gene_biotype: protein_coding
description:
  Pre-mRNA-processing protein prp40; Required for pre-spliceosome formation, which is the first step of pre-mRNA splicing. This protein is associated with snRNP U1 (By similarity).


ensembl_gene_id: O14177
symbol: did4
gene_biotype: protein_coding
description:
  ESCRT-III complex subunit did4; Required for the sorting and concentration of proteins resulting in the entry of these proteins into the invaginating vesicles of the multivesicular body (MVB). Acts a component of the ESCRT-III complex, which appears to be critical for late steps in MVB sorting, such as membrane invagination and final cargo sorting and recruitment of late-acting components of the sorting machinery. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complex assemblies (By similarity); Belongs to the SNF7 family.


ensembl_gene_id: O14178
symbol: mrpl40
gene_biotype: protein_coding
description:
  54S ribosomal protein L40, mitochondrial; Involved in mitochondrial genome encoded proteins translation.


ensembl_gene_id: O14179
symbol: sdo1
gene_biotype: protein_coding
description:
  Ribosome maturation protein sdo1; Involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with the EF-2-like GTPase ria1, may trigger the GTP-dependent release of tif6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating tif6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export.


ensembl_gene_id: O14181
symbol: mrpl28
gene_biotype: protein_coding
description:
  54S ribosomal protein L28, mitochondrial; Involved in mitochondrial genome encoded proteins translation.


ensembl_gene_id: O14185
symbol: stg1
gene_biotype: protein_coding
description:
  Transgelin; Has actin-binding and actin-bundling activity and is a component of the actin patch. Stabilizes actin filaments against disassembly. Cross-links F-actin and is required for the formation of the contractile F-actin ring.


ensembl_gene_id: O14187
symbol: spp42
gene_biotype: protein_coding
description:
  Pre-mRNA-splicing factor spp42; Involved in pre-mRNA splicing. May be involved in endoplasmic reticulum-associated protein degradation (ERAD) and required for growth at low and high temperatures (By similarity). Required for pre- spliceosome formation, which is the first step of pre-mRNA splicing. This protein is associated with snRNP U5. Has a role in branch site-3' splice site selection. Associates with the branch site-3' splice 3'- exon region.


ensembl_gene_id: O14188
symbol: rng2
gene_biotype: protein_coding
description:
  Ras GTPase-activating-like protein rng2; Required for cytokinesis. Component of the contractile F- actin ring; required for its construction following assembly of F-actin at the division site.


ensembl_gene_id: O14189
symbol: SPAC10F6.17c
gene_biotype: protein_coding
description:
  Protein phosphatase 2C homolog C10F6.17c; Involved in regulation of pyruvate dehydrogenase activity.


ensembl_gene_id: O14190
symbol: alg13
gene_biotype: protein_coding
description:
  UDP-N-acetylglucosamine transferase subunit alg13; Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway (By similarity). Belongs to the glycosyltransferase 28 family.


ensembl_gene_id: O14192
symbol: SPAC56E4.03
gene_biotype: protein_coding
description:
  Aromatic amino acid aminotransferase C56E4.03; Has aromatic amino acid transaminase activity. Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.


ensembl_gene_id: O14193
symbol: snd2
gene_biotype: protein_coding
description:
  SRP-independent targeting protein 2 homolog; May function in a SRP (signal recognition particle) and GET (guided entry of tail-anchored proteins) independent pathway for targeting a broad range of substrate proteins to the endoplasmic reticulum (By similarity). Has a role in meiosis. Belongs to the TMEM208 family.


ensembl_gene_id: O14194
symbol: ggt2
gene_biotype: protein_coding
description:
  Glutathione hydrolase 2 heavy chain; Catalyzes the transfer of the gamma-glutamyl moiety of glutathione (GSH) and other gamma-glutamyl compounds to amino acids and peptides. Major GSH-degrading enzyme, catalyzing the hydrolytic release of L-glutamate from GSH. Plays a role in the turnover of the vacuolar GSH, serving as an alternative nitrogen source during nitrogen starvation (By similarity).


ensembl_gene_id: O14198
symbol: med18
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 18; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.


ensembl_gene_id: O14199
symbol: alg14
gene_biotype: protein_coding
description:
  UDP-N-acetylglucosamine transferase subunit alg14; Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway. Anchors the catalytic subunit alg13 to the ER (By similarity).


ensembl_gene_id: O14200
symbol: pxa1
gene_biotype: protein_coding
description:
  PXA domain protein 1; Required for required for normal vacuolar morphology and for vacuolar protein transport. Also required for endosome-to-Golgi protein transport.


ensembl_gene_id: O14201
symbol: mug86
gene_biotype: protein_coding
description:
  Meiotically up-regulated gene 86 protein; Has a role in meiosis; Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.


ensembl_gene_id: O14205
symbol: gpp74
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 74; Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Mediates the cis and medial Golgi localization of mannosyltransf [...]


ensembl_gene_id: O14207
symbol: mus7
gene_biotype: protein_coding
description:
  Protein mms22; Involved in protection against replication-dependent DNA damage. May act by restoring active replication forks, repairing unusual DNA structures, and/or preventing aberrant DNA rearrangement at arrested replication forks; Belongs to the MMS22 family.


ensembl_gene_id: O14209
symbol: SPAC6B12.04c
gene_biotype: protein_coding
description:
  Uncharacterized aminotransferase C6B12.04c; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.


ensembl_gene_id: O14210
symbol: ies2
gene_biotype: protein_coding
description:
  INO80 complex subunit 2; Component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.


ensembl_gene_id: O14211
symbol: rrg9
gene_biotype: protein_coding
description:
  Required for respiratory growth protein 9, mitochondrial; Required for respiratory activity and maintenance and expression of the mitochondrial genome; Belongs to the RRG9 family.


ensembl_gene_id: O14214
symbol: trm10
gene_biotype: protein_coding
description:
  tRNA (guanine(9)-N1)-methyltransferase; S-adenosyl-L-methionine-dependent guanine N(1)- methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in cytoplasmic tRNA.


ensembl_gene_id: O14215
symbol: spp1
gene_biotype: protein_coding
description:
  DNA primase small subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase small subunit family.


ensembl_gene_id: O14216
symbol: drc1
gene_biotype: protein_coding
description:
  DNA replication regulator sld2; Has a role in the initiation of DNA replication. Required at S-phase checkpoint; Belongs to the SLD2 family.


ensembl_gene_id: O14217
symbol: tom70
gene_biotype: protein_coding
description:
  Probable mitochondrial import receptor subunit tom70; Receptor that accelerates the import of all mitochondrial precursor proteins.


ensembl_gene_id: O14218
symbol: SPAC6B12.13
gene_biotype: protein_coding
description:
  Type 1 phosphatases regulator ypi1; Regulator of type 1 phosphatases which maintains protein phosphatase activity under strict control; Belongs to the YPI1 family.


ensembl_gene_id: O14222
symbol: fsv1
gene_biotype: protein_coding
description:
  Syntaxin-like protein fsv1; Involved in vesicle-mediated protein transport between the Golgi and the vacuole.


ensembl_gene_id: O14223
symbol: tvp15
gene_biotype: protein_coding
description:
  Golgi apparatus membrane protein tvp15; Golgi membrane protein involved in vesicular trafficking. Belongs to the TVP15 family.


ensembl_gene_id: O14224
symbol: rdi1
gene_biotype: protein_coding
description:
  Rho GDP-dissociation inhibitor; Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.


ensembl_gene_id: O14225
symbol: tom20
gene_biotype: protein_coding
description:
  Mitochondrial import receptor subunit tom20; Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with tom22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the translocation pore (By similarity).


ensembl_gene_id: O14226
symbol: exo84
gene_biotype: protein_coding
description:
  Exocyst complex component exo84; Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Plays a role in both the assembly of the exocyst and the polarization of this complex to specific sites of the plasma membrane for exocytosis. Also involved in assembly of the spliceosome (By similarity).


ensembl_gene_id: O14227
symbol: rdp1
gene_biotype: protein_coding
description:
  RNA-dependent RNA polymerase 1; Has a role in the RNA interference (RNAi) pathway which is important for heterochromatin formation, accurate chromosome segregation, centromere cohesion and telomere function during mitosis and meiosis. Required for both post-transcriptional and transcriptional gene silencing. Required for silencing at the centromeres and for initiation of transcriptionally silent heterochromatin at the mating type locus. Promotes histone H3 'Lys-10' methylation necessary for centromere function. Required for recruitment of swi6 and cohesin to an ectopic dg repeat. A mem [...]


ensembl_gene_id: O14228
symbol: ade3
gene_biotype: protein_coding
description:
  Probable phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate (By similarity); In the N-terminal section; belongs to the FGAMS family.


ensembl_gene_id: O14229
symbol: sfc1
gene_biotype: protein_coding
description:
  Transcription factor tau subunit sfc1; TFIIIC mediates tRNA and 5S RNA gene activation by binding to intragenic promoter elements. Upstream of the transcription start site, TFIIIC assembles the initiation complex TFIIIB-TFIIIC-tDNA, which is sufficient for RNA polymerase III recruitment and function. Part of the tauA domain of TFIIIC that binds boxA DNA promoter sites of tRNA and similar genes. Participates in the interconnection of tauA with tauB via its contacts with sfc3 and sfc6. Serves as a scaffold critical for tauA-DNA spatial configuration and tauB-DNA stability. Localizes to c [...]


ensembl_gene_id: O14230
symbol: fps1
gene_biotype: protein_coding
description:
  Farnesyl pyrophosphate synthase; Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate; Belongs to the FPP/GGPP synthase family.


ensembl_gene_id: O14232
symbol: mtr4
gene_biotype: protein_coding
description:
  ATP-dependent RNA helicase mtr4; Component of the TRAMP complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism limiting inappropriate expression of genetic information. Polyadenylation is required for the degradative activity of the exosome on several of its nuclear RNA substrates (By similarity). Required for heterochromatic gene silencing at centromeric repeats by either exosome- or RNAi-mediated degradation of heterochromatic transcripts.


ensembl_gene_id: O14233
symbol: rna14
gene_biotype: protein_coding
description:
  mRNA 3'-end-processing protein rna14; Component of the cleavage factor IA (CFIA) complex, which is involved in the endonucleolytic cleavage during polyadenylation- dependent pre-mRNA 3'-end formation.


ensembl_gene_id: O14234
symbol: cch1
gene_biotype: protein_coding
description:
  Calcium-channel protein cch1; Voltage-gated, high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones. Functions together with yam8 to ensure that adequate levels of Ca(2+) are supplied to pmr1 to sustain secretion and growth. Required for growth in low-calcium environments (By similarity).


ensembl_gene_id: O14236
symbol: nog2
gene_biotype: protein_coding
description:
  Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.


ensembl_gene_id: O14238
symbol: ost2
gene_biotype: protein_coding
description:
  Probable dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit ost2; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation a [...]


ensembl_gene_id: O14239
symbol: rax2
gene_biotype: protein_coding
description:
  Polarized growth protein rax2; Controls cell polarity, through the G1 phase of mitosis, via regulation of for3 localization. Required for actin cable formation where it directs the spatial distribution of the actin cables.


ensembl_gene_id: O14240
symbol: eaf6
gene_biotype: protein_coding
description:
  Chromatin modification-related protein eaf6; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity). Component of the mst2 complex which is a highly specific H3 lysine 14 (H3K14) acetyltransferase that functions together with gcn5 to regulate global levels of H3K14 acetylation (H3K14ac), critical for DNA damage checkpoint activation.


ensembl_gene_id: O14241
symbol: arc2
gene_biotype: protein_coding
description:
  Actin-related protein 2/3 complex subunit 2; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament (By similarity).


ensembl_gene_id: O14242
symbol: SPAC6F6.11c
gene_biotype: protein_coding
description:
  Putative pyridoxal kinase C6F6.11c; Required for synthesis of pyridoxal-5-phosphate from vitamin B6; Belongs to the pyridoxine kinase family.


ensembl_gene_id: O14243
symbol: atg24
gene_biotype: protein_coding
description:
  Sorting nexin-4; Sorting nexin, involved in the separation or division of vacuoles throughout the entire life cycle of the cells. Involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans- Golgi network, for cytoplasm to vacuole transport (Cvt), mitophagy, and pexophagy (By similarity).


ensembl_gene_id: O14246
symbol: tpz1
gene_biotype: protein_coding
description:
  Protection of telomeres protein tpz1; Telomeric DNA-binding protein that is required to protect the 3'-end telomeric overhang and involved in telomere length regulation. recruits poz1 and ccq1 to telomeres, regulating telomere length negatively and positivels respectively.


ensembl_gene_id: O14248
symbol: tea3
gene_biotype: protein_coding
description:
  Tip elongation aberrant protein 3; Acts as a cell end marker required for efficient new end take-off (NETO), whereby growth is activated at the cell end to generate bipolarity in extending cells. Also required for proper placement of the septum.


ensembl_gene_id: O14249
symbol: cld1
gene_biotype: protein_coding
description:
  Probable cardiolipin-specific deacylase, mitochondrial; Mitochondrial cardiolipin-specific phospholipase which deacylates de novo synthesized cardiolipin. Part of the remodeling process of cardiolipin, which involves deacylation-reacylation of premature cardiolipin (By similarity).


ensembl_gene_id: O14250
symbol: pre5
gene_biotype: protein_coding
description:
  Probable proteasome subunit alpha type-6; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity); Belongs to the peptidase T1A family.


ensembl_gene_id: O14251
symbol: trs120
gene_biotype: protein_coding
description:
  Transport protein particle subunit trs120; Component of the TRAPP II complex. TRAPP II seems to play a role in intra-Golgi transport (By similarity).


ensembl_gene_id: O14252
symbol: tda3
gene_biotype: protein_coding
description:
  Putative oxidoreductase C6G10.06; Putative oxidoreductase that negatively regulates the retrieval of cargo from late endosomes to the Golgi.


ensembl_gene_id: O14253
symbol: cbc1
gene_biotype: protein_coding
description:
  Nuclear cap-binding protein subunit 1; Component of the CBC complex, which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in maturation, export and degradation of nuclear mRNAs.


ensembl_gene_id: O14255
symbol: gls1
gene_biotype: protein_coding
description:
  Probable mannosyl-oligosaccharide glucosidase; Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor highly specifically.


ensembl_gene_id: O14258
symbol: ace2
gene_biotype: protein_coding
description:
  Metallothionein expression activator; Regulates the transcription of genes required for cell separation.


ensembl_gene_id: O14259
symbol: sfp47
gene_biotype: protein_coding
description:
  Ubp4-interactor sfp47; Required for the regulation of activity and recruitment of ubp4 to endosomes.


ensembl_gene_id: O14261
symbol: atg11
gene_biotype: protein_coding
description:
  Taz1-interacting factor 1; Involved in cytoplasm to vacuole transport (Cvt), pexophagy, mitophagy and nucleophagy. Recruits mitochondria for their selective degradation via autophagy (mitophagy) during starvation. Works as scaffold proteins that recruit ATG proteins to the preautophagosome (PAS), the site of vesicle/autophagosome formation. Required for atg9 anterograde transport from the mitochondria to the PAS (By similarity). Required for nitrogen starvation-induced sexual development and for entering the dormant G0 state (By similarity); Belongs to the ATG11 family.


ensembl_gene_id: O14265
symbol: vma13
gene_biotype: protein_coding
description:
  V-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (By similarity).


ensembl_gene_id: O14266
symbol: sec39
gene_biotype: protein_coding
description:
  Protein transport protein sec39; Required for protein transport between the Golgi and the endoplasmic reticulum. May contribute to tethering of coatomer-coated retrograde transport vesicles to the ER membrane through interaction with and stabilization of the SNARE complex (By similarity).


ensembl_gene_id: O14270
symbol: fhl1
gene_biotype: protein_coding
description:
  Fork head transcription factor 1; Acts as a transcriptional activator with a role in the regulation of mitosis. Required for the correct timing, positioning and contraction of the division septum.


ensembl_gene_id: O14274
symbol: dtd1
gene_biotype: protein_coding
description:
  D-aminoacyl-tRNA deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family.


ensembl_gene_id: O14275
symbol: ppr4
gene_biotype: protein_coding
description:
  Pentatricopeptide repeat-containing protein 4, mitochondrial; Mitochondrial RNA-binding protein that specifically activates the translation of the cox1 mRNA.


ensembl_gene_id: O14276
symbol: fyv7
gene_biotype: protein_coding
description:
  rRNA-processing protein fyv7; Involved in the processing of the 20S pre-rRNA. Belongs to the FYV7 family.


ensembl_gene_id: O14279
symbol: rrp14
gene_biotype: protein_coding
description:
  Ribosomal RNA-processing protein 14-N; Involved in ribosome biogenesis and cell polarity. Required for the synthesis of both 40S and 60S ribosomal subunits and may also play some direct role in correct positioning of the mitotic spindle during mitosis (By similarity); Belongs to the SURF6 family.


ensembl_gene_id: O14283
symbol: prr1
gene_biotype: protein_coding
description:
  Transcription factor prr1; Involved in oxidative stress. Transcription factor that acts upon trr1 and ctt1; In the N-terminal section; belongs to the HSF family.


ensembl_gene_id: O14284
symbol: oxr1
gene_biotype: protein_coding
description:
  Oxidation resistance protein 1; May be involved in protection from oxidative damage (By similarity). Has a role in meiosis; Belongs to the OXR1 family.


ensembl_gene_id: O14285
symbol: spc34
gene_biotype: protein_coding
description:
  DASH complex subunit spc34; Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore.


ensembl_gene_id: O14286
symbol: atm1
gene_biotype: protein_coding
description:
  Iron-sulfur clusters transporter atm1, mitochondrial; Performs an essential function in the generation of cytoplasmic iron-sulfur proteins by mediating the ATP-dependent export of Fe/S cluster precursors synthesized by NFS1 and other mitochondrial proteins. Hydrolyzes ATP. Binds glutathione and may function by transporting a glutathione-conjugated iron-sulfur compound. Also has an indirect role in vacuolar function where it is required for fluid-phase endocytosis.


ensembl_gene_id: O14289
symbol: leu2
gene_biotype: protein_coding
description:
  3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate; Belongs to the aconitase/IPM isomerase family.


ensembl_gene_id: O14293
symbol: atd1
gene_biotype: protein_coding
description:
  Putative aldehyde dehydrogenase-like protein C9E9.09c; Belongs to the aldehyde dehydrogenase family.


ensembl_gene_id: O14295
symbol: plr1
gene_biotype: protein_coding
description:
  Pyridoxal reductase; Catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+).


ensembl_gene_id: O14296
symbol: vps24
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 24; Class E VPS protein implicated in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles. The lumenal sequestrated membrane proteins will be targeted into the vacuole after fusion of the endosome with the vacuole.


ensembl_gene_id: O14299
symbol: wis4
gene_biotype: protein_coding
description:
  MAP kinase kinase kinase wis4; Involved in a signal transduction pathway that is activated in under conditions of heat shock, oxidative stress or limited nutrition. Unlike win1, it is not activated by changes in the osmolarity of the extracellular environment. Activates the wis1 MAP kinase kinase by phosphorylation.


ensembl_gene_id: O14300
symbol: oxa101
gene_biotype: protein_coding
description:
  Mitochondrial inner membrane protein oxa1-1; Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome c oxidase. Not essential for viability, while oxa102 is essential. When both genes are deleted the cell is non- viable, suggesting that oxa101 act as a back-up for oxa102. Belongs to the OXA1/ALB3/YidC family.


ensembl_gene_id: O14305
symbol: sid1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase sid1; Has a role in the septation initiation network (SIN) required for cytokinesis.


ensembl_gene_id: O14307
symbol: cpd1
gene_biotype: protein_coding
description:
  tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit trm61; Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.


ensembl_gene_id: O14308
symbol: swc4
gene_biotype: protein_coding
description:
  SWR1-complex protein 4; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity).


ensembl_gene_id: O14311
symbol: spt3
gene_biotype: protein_coding
description:
  SAGA complex subunit spt3; Functions as component of the transcription regulatory histone acetylation (HAT) complex SAGA. SAGA is involved in RNA polymerase II-dependent transcriptional regulation. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (spt3, spt8 and spt20) and promoter selectivity, interaction with transcription activators (gcn5, ada2, ada3 and tra1), and chromatin modification through histone acetylation (gcn5) and deubiquit [...]


ensembl_gene_id: O14313
symbol: pmp20
gene_biotype: protein_coding
description:
  Peroxisomal membrane associated protein 20; May act as a chaperone rather than a peroxidase. Has no thioredoxin-dependent peroxidase activity. Shows weak chaperone activity; Belongs to the peroxiredoxin family. Prx5 subfamily.


ensembl_gene_id: O14317
symbol: rpp203
gene_biotype: protein_coding
description:
  60S acidic ribosomal protein P2-C; Plays an important role in the elongation step of protein synthesis; Belongs to the eukaryotic ribosomal protein P1/P2 family.


ensembl_gene_id: O14318
symbol: php4
gene_biotype: protein_coding
description:
  CCAAT-binding factor complex subunit php4; Component of the transcription regulatory CCAAT-binding complex. Required for the reprogramming of the cell for iron use. Downregulates pcl1, sdh4, and isa1 underlow-iron conditions.


ensembl_gene_id: O14320
symbol: coa1
gene_biotype: protein_coding
description:
  Cytochrome c oxidase assembly factor 1; Required for efficient assembly of cytochrome c oxidase in the mitochondrial inner membrane. Involved in a step coupling MSS51- dependent cotranslational insertion of COX1 to the addition of its heme A and copper B cofactors (By similarity); Belongs to the COA1 family.


ensembl_gene_id: O14321
symbol: erg6
gene_biotype: protein_coding
description:
  Sterol 24-C-methyltransferase erg6; Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of lanosterol to form eburicol (Probable). Involved in the biosynthesis or ergosterol which is important for plasma membrane structure and function and for localization of plasma membrane proteins.


ensembl_gene_id: O14326
symbol: pub3
gene_biotype: protein_coding
description:
  E3 ubiquitin-protein ligase pub3; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.


ensembl_gene_id: O14329
symbol: zrg17
gene_biotype: protein_coding
description:
  Probable zinc transporter zrg17; Probable transporter involved in the regulation of zinc homeostasis; Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.


ensembl_gene_id: O14332
symbol: rem1
gene_biotype: protein_coding
description:
  Meiosis-specific cyclin rem1; Required for pre-meiotic DNA synthesis and S phase progression. Regulates levels of meiotic intragenic recombination.


ensembl_gene_id: O14333
symbol: psd1
gene_biotype: protein_coding
description:
  Phosphatidylserine decarboxylase proenzyme 1, mitochondrial; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine (By similarity). Together with psd2 and psd3, responsible for the majority of phosphatidylethanolamine synthesis. Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.


ensembl_gene_id: O14334
symbol: pfd1
gene_biotype: protein_coding
description:
  Probable prefoldin subunit 1; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity); Belongs to the prefoldin subunit beta family.


ensembl_gene_id: O14335
symbol: scr1
gene_biotype: protein_coding
description:
  DNA-binding protein scr1; Involved in carbon catabolite repression. Represses the transcription of various genes including the inv1 gene. Belongs to the creA/MIG C2H2-type zinc-finger protein family.


ensembl_gene_id: O14341
symbol: mrpl35
gene_biotype: protein_coding
description:
  54S ribosomal protein L35, mitochondrial; Belongs to the phosphatidylethanolamine-binding protein family. Mitochondrion-specific ribosomal protein mL38 subfamily.


ensembl_gene_id: O14343
symbol: klp5
gene_biotype: protein_coding
description:
  Kinesin-like protein 5; Has a role in establishing metaphase during mitosis. Required for chromosome segregation where it generates tension during kinetochore capturing; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily.


ensembl_gene_id: O14344
symbol: gua1
gene_biotype: protein_coding
description:
  Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.


ensembl_gene_id: O14345
symbol: pfa3
gene_biotype: protein_coding
description:
  Palmitoyltransferase pfa3; Palmitoyltransferase specific for VAC8. Palmitoylates VAC8 at one or more of its N-terminal cysteine residues, which is required for its proper membrane localization (By similarity).


ensembl_gene_id: O14346
symbol: phs1
gene_biotype: protein_coding
description:
  Probable very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as pr [...]


ensembl_gene_id: O14349
symbol: isn1
gene_biotype: protein_coding
description:
  IMP-specific 5'-nucleotidase 1; IMP-specific 5'-nucleotidase involved in IMP (inositol monophosphate) degradation; Belongs to the ISN1 family.


ensembl_gene_id: O14350
symbol: swi3
gene_biotype: protein_coding
description:
  Swi1-interacting protein swi3; Forms a fork protection complex (FPC) with swi1. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. It is required for programmed fork-pausing which is necessary for mating-type switching. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors. It is involved in termination at the mat1-proximal polar- terminator of replication (RTS1) and also required for activation of the Rad53-like checkpoint kinase cds1; Belongs to the CSM3 family.


ensembl_gene_id: O14351
symbol: SPBC30D10.05c
gene_biotype: protein_coding
description:
  Uncharacterized oxidoreductase C30D10.05c; Belongs to the short-chain dehydrogenases/reductases (SDR) family.


ensembl_gene_id: O14352
symbol: lsm4
gene_biotype: protein_coding
description:
  Probable U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA.


ensembl_gene_id: O14353
symbol: bpl1
gene_biotype: protein_coding
description:
  Biotin--[propionyl-CoA-carboxylase [ATP-hydrolyzing]] ligase; Post-translational modification of specific protein by attachment of biotin. Acts on various carboxylases such as acetyl-CoA- carboxylase, pyruvate carboxylase, propionyl CoA carboxylase, and 3- methylcrotonyl CoA carboxylase (By similarity).


ensembl_gene_id: O14354
symbol: mgm101
gene_biotype: protein_coding
description:
  Mitochondrial genome maintenance protein mgm101; Performs an essential function in the repair of oxidatively damaged mtDNA that is required for the maintenance of the mitochondrial genome. Binds to DNA (By similarity); Belongs to the MGM101 family.


ensembl_gene_id: O14356
symbol: tor1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase tor1; Phosphatidylinositol 3-kinase homolog, component of TORC2, which regulates multiple cellular processes to control cell growth in response to environmental signals. TORC2 is required for cell survival under various stress conditions. TORC2 positively controls G1 cell- cycle arrest, sexual development and amino acid uptake. Positively regulates amino acid uptake through the control of expression of amino acid permeases. Responsible for the phosphorylation of AGC kinase gad8 at 'Ser-527' and 'Ser-546', activating gad8 kinase activity and promoting sex [...]


ensembl_gene_id: O14357
symbol: gpi1
gene_biotype: protein_coding
description:
  N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein gpi1; Necessary for the synthesis of N-acetylglucosaminyl- phosphatidylinositol, the very early intermediate in GPI-anchor biosynthesis.


ensembl_gene_id: O14358
symbol: rsm27
gene_biotype: protein_coding
description:
  37S ribosomal protein S27, mitochondrial; Involved in mitochondrial genome encoded proteins translation.


ensembl_gene_id: O14360
symbol: naf1
gene_biotype: protein_coding
description:
  H/ACA ribonucleoprotein complex non-core subunit NAF1; RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by GAR1 to yield mature H/ACA snoRNPs complex (By similarity).


ensembl_gene_id: O14361
symbol: pha2
gene_biotype: protein_coding
description:
  Putative prephenate dehydratase; Putative prephenate dehydratase required for the syntheis of L-phenylalanine; Belongs to the PHA2 family.


ensembl_gene_id: O14362
symbol: smi1
gene_biotype: protein_coding
description:
  Cell wall biosynthesis/cell cycle regulator smi1; Protein involved in the regulation of cell wall assembly and 1,3-beta-glucan synthesis, possibly through the transcriptional regulation of cell wall glucan and chitin synthesis (By similarity). Involved in cellular response to nitrogen starvation and required for quiescence-maintenance by regulating negatively G0 to G1 transition. Belongs to the KNR4/SMI1 family.


ensembl_gene_id: O14370
symbol: eca39
gene_biotype: protein_coding
description:
  Branched-chain-amino-acid aminotransferase, mitochondrial; Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.


ensembl_gene_id: O14400
symbol: gut2
gene_biotype: protein_coding
description:
  Glycerol-3-phosphate dehydrogenase, mitochondrial; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.


ensembl_gene_id: O14417
symbol: mad2
gene_biotype: protein_coding
description:
  Mitotic spindle checkpoint component mad2; Feedback control that prevents cells with incompletely assembled spindles from leaving mitosis. It interacts with the anaphase promoting complex/cyclosome (APC/C) thereby inhibiting APC/C-dependent proteolysis, a step required for exit from mitosis. Belongs to the MAD2 family.


ensembl_gene_id: O14423
symbol: cbh1
gene_biotype: protein_coding
description:
  CENP-B homolog protein 1; Binds to centromeric K-type repeat DNA and ARS3002 DNA. The CBH-binding consensus sequence is Py-Pu-A-T-A-T-Py-Pu-T-A.


ensembl_gene_id: O14443
symbol: fet5
gene_biotype: protein_coding
description:
  GPN-loop GTPase 3; Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.


ensembl_gene_id: O14450
symbol: pfd6
gene_biotype: protein_coding
description:
  Probable prefoldin subunit 6; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity); Belongs to the prefoldin subunit beta family.


ensembl_gene_id: O14459
symbol: rpb7
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerase II subunit rpb7; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB7 is part of a subcomplex with RPB4 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems  [...]


ensembl_gene_id: O14460
symbol: eft201
gene_biotype: protein_coding
description:
  Elongation factor 2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity); Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF [...]


ensembl_gene_id: O14463
symbol: trx1
gene_biotype: protein_coding
description:
  Thioredoxin-1; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.


ensembl_gene_id: O14466
symbol: dpm1
gene_biotype: protein_coding
description:
  Dolichol-phosphate mannosyltransferase; Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; Belongs to the glycosyltransferase 2 family.


ensembl_gene_id: O14470
symbol: ssr2
gene_biotype: protein_coding
description:
  SWI/SNF and RSC complexes subunit ssr2; Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. Controls particularly membrane and organelle development genes. Part of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing bindin [...]


ensembl_gene_id: O36014
symbol: ape4
gene_biotype: protein_coding
description:
  Aspartyl aminopeptidase 1; Aspartyl aminopeptidase that is able to remove aspartyl residue at N-terminus of angiotensin I. Acts also as a chaperone and efficiently suppressed the thermal aggregation of citrate synthase.


ensembl_gene_id: O36015
symbol: trm7
gene_biotype: protein_coding
description:
  Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.


ensembl_gene_id: O36016
symbol: ypa1
gene_biotype: protein_coding
description:
  Serine/threonine-protein phosphatase 2A activator 1; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A- phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex (By similarity).


ensembl_gene_id: O36017
symbol: lip2
gene_biotype: protein_coding
description:
  Probable octanoyltransferase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity); Belongs to the LipB family.


ensembl_gene_id: O36019
symbol: atg13
gene_biotype: protein_coding
description:
  Autophagy protein 13; Activates the atg1 kinase in a nutritional condition dependent manner through the TOR pathway, leading to autophagy. Also involved in cytoplasm to vacuole transport (Cvt) and more specifically in Cvt vesicle formation. Seems to play a role in the switching machinery regulating the conversion between the Cvt pathway and autophagy. Autophagy functions to supply nitrogen and is activated when cells cannot access exogenous nitrogen, thus ensuring that they can adapt and subsequently propagate. Finally, atg13 is also required for glycogen storage during stationary phas [...]


ensembl_gene_id: O36022
symbol: mnn9
gene_biotype: protein_coding
description:
  Mannan polymerase complex subunit mnn9; Required for the addition of the long alpha 1,6-mannose backbone of N-linked glycans on cell wall and periplasmic proteins.


ensembl_gene_id: O36023
symbol: spn1
gene_biotype: protein_coding
description:
  Septin homolog spn1; Plays a role in the cell cycle. Involved in a late stage of septum formation leading to the separation of the daughter cells.


ensembl_gene_id: O36024
symbol: fta1
gene_biotype: protein_coding
description:
  Inner kinetochore subunit fta1; Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.


ensembl_gene_id: O36025
symbol: mpd2
gene_biotype: protein_coding
description:
  GYF domain-containing protein mpd2; Has a role in mRNA export from the nucleus. Belongs to the SMY2/mpd2 family.


ensembl_gene_id: O36027
symbol: wsp1
gene_biotype: protein_coding
description:
  Wiskott-Aldrich syndrome protein homolog 1; Has a role in regulating actin assembly, so regulating polarized growth.


ensembl_gene_id: O36028
symbol: SPAC4F10.16c
gene_biotype: protein_coding
description:
  Putative phospholipid-transporting ATPase C4F10.16c; Catalyzes the hydrolysis of ATP coupled with the transport of phospholipids.


ensembl_gene_id: O36032
symbol: grx1
gene_biotype: protein_coding
description:
  Glutaredoxin-1; The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing some disulfides in a coupled system with glutathione reductase. Thioltransferase catalyzes cellular thiol-disulfide transhydrogenation reactions. It transfers reducing equivalents to cytosolic protein and nonprotein disulfides (By similarity).


ensembl_gene_id: O42634
symbol: dmc1
gene_biotype: protein_coding
description:
  Meiotic recombination protein dmc1; Required for meiotic recombination and cell cycle progression. Binds to single and double-stranded DNA, in the presence of magnesium, and exhibits DNA-dependent ATPase activity. Promotes DNA strand annealing and strand exchange via DNA recombinase activity and forms helical and stacked ring nucleoprotein filaments. Belongs to the RecA family. DMC1 subfamily.


ensembl_gene_id: O42643
symbol: prp22
gene_biotype: protein_coding
description:
  Pre-mRNA-splicing factor ATP-dependent RNA helicase prp22; Acts late in the splicing of pre-mRNA. Required for the splicing of introns with a branch nucleotide to 3'-splice site distance greater or equal to 15. Mediates the release of the spliced mRNA from spliceosomes; Belongs to the DEAD box helicase family. DEAH subfamily. DDX8/PRP22 sub-subfamily.


ensembl_gene_id: O42644
symbol: cts1
gene_biotype: protein_coding
description:
  CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.


ensembl_gene_id: O42646
symbol: ubc6
gene_biotype: protein_coding
description:
  Ubiquitin-conjugating enzyme E2 6; Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in degradation of misfolded or regulated proteins localized in the endoplasmic reticulum (ER) lumen or membrane via the ubiquitin-proteasome system. Cognate E2 conjugating enzyme for the doa10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of membrane proteins with misfolded cytoplasmic domains.


ensembl_gene_id: O42649
symbol: psm3
gene_biotype: protein_coding
description:
  Structural maintenance of chromosomes protein 3; Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate; Belongs to the SMC family. SMC3 subfamily.


ensembl_gene_id: O42650
symbol: rio1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase rio1; Required for the final endonucleolytic cleavage at site D converting 20S pre-rRNA into the mature 18S rRNA. Required for the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Despite the protein kinase domain is proposed to act predominantly as an ATPase (By similarity).


ensembl_gene_id: O42651
symbol: atg17
gene_biotype: protein_coding
description:
  Autophagy-related protein 17; Autophagy-specific protein that functions in response to autophagy-inducing signals as a scaffold to recruit other ATG proteins to organize preautophagosomal structure (PAS) formation. Modulates the timing and magnitude of the autophagy response, such as the size of the sequestering vesicles. Plays particularly a role in pexophagy and nucleophagy (By similarity).


ensembl_gene_id: O42652
symbol: caa1
gene_biotype: protein_coding
description:
  Aspartate aminotransferase, cytoplasmic; Plays a key role in amino acid metabolism; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.


ensembl_gene_id: O42653
symbol: SPAC10F6.14c
gene_biotype: protein_coding
description:
  ABC1 family protein C10F6.14c; Belongs to the protein kinase superfamily. ADCK protein kinase family.


ensembl_gene_id: O42656
symbol: ric1
gene_biotype: protein_coding
description:
  Guanine nucleotide exchange factor subunit ric1; Probable component of a guanine nucleotide exchange factor (GEF) that may be required for efficient fusion of endosome-derived vesicles with the Golgi.


ensembl_gene_id: O42659
symbol: apc14
gene_biotype: protein_coding
description:
  Anaphase-promoting complex subunit 14; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. Appears to have some sort of role in spore wall formation.


ensembl_gene_id: O42661
symbol: smd1
gene_biotype: protein_coding
description:
  Small nuclear ribonucleoprotein Sm D1; Involved in pre-mRNA splicing. Binds snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site (By similarity).


ensembl_gene_id: O42662
symbol: mtl16
gene_biotype: protein_coding
description:
  U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase; RNA N6-methyltransferase that mediates N6-methylation of adenine of U6 small nuclear RNA (U6 snRNA).


ensembl_gene_id: O42666
symbol: but1
gene_biotype: protein_coding
description:
  Uba3-binding protein but1; Acts as a negative regulator of the NEDD8 pathway. Has a role in meiosis.


ensembl_gene_id: O42667
symbol: ssm4
gene_biotype: protein_coding
description:
  Microtubule-associated protein ssm4; Binds to nuclear microtubules with the effect of either modifying their structure or function. This then promotes meiotic nuclear division.


ensembl_gene_id: O42700
symbol: tal1
gene_biotype: protein_coding
description:
  Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 1 subfamily.


ensembl_gene_id: O42709
symbol: cdc23
gene_biotype: protein_coding
description:
  DNA replication licensing factor mcm10; Required for DNA synthesis. Required for entry into or completion of S phase. Involved in DNA replication and seems to participate in the activation of the pre-replication complex (pre-RC) and in transcription elongation. May play a role as key coordinator in assembling the replication fork. Proposed to function at replication origins following the binding of the mcm2-7 complex prior to the recruitment of sna41. Probably is required to stimulate phosphorylation of the mcm2-7 complex by the dfp1-hsk1 kinase complex. May recruit the DNA polymerase  [...]


ensembl_gene_id: O42832
symbol: spb1
gene_biotype: protein_coding
description:
  AdoMet-dependent rRNA methyltransferase spb1; Required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.


ensembl_gene_id: O42839
symbol: cut20
gene_biotype: protein_coding
description:
  Anaphase-promoting complex subunit 4; Component of the anaphase-promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. Has a role in promoting metaphase to anaphase transition via the ubiquitination of specific mitotic substrates.


ensembl_gene_id: O42842
symbol: apt1
gene_biotype: protein_coding
description:
  Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family.


ensembl_gene_id: O42844
symbol: cmk2
gene_biotype: protein_coding
description:
  Calcium/calmodulin-dependent protein kinase type II; Has a role in the regulation of G2/M transition during mitosis; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.


ensembl_gene_id: O42852
symbol: sec20
gene_biotype: protein_coding
description:
  Protein transport protein sec20; SNARE required for targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.


ensembl_gene_id: O42853
symbol: rtr1
gene_biotype: protein_coding
description:
  Putative RNA polymerase II subunit B1 CTD phosphatase rtr1; Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation. Belongs to the RPAP2 family.


ensembl_gene_id: O42857
symbol: npr2
gene_biotype: protein_coding
description:
  Nitrogen permease regulator 2 homolog; Mediates inactivation of the TORC1 complex in response to amino acid starvation. Post-transcriptional regulator of nitrogen permeases (By similarity); Belongs to the NPR2 family.


ensembl_gene_id: O42860
symbol: bub3
gene_biotype: protein_coding
description:
  Mitotic checkpoint protein bub3; Involved in cell cycle checkpoint enforcement. Involved in recruitment of checkpoint proteins bub1 and mad3 to the kinetochores, ensuring correct spindle checkpoint function. Belongs to the WD repeat BUB3 family.


ensembl_gene_id: O42861
symbol: fft3
gene_biotype: protein_coding
description:
  ATP-dependent helicase fft3; DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for heterochromatin organization. Required for maintaining a heterochromatin chromatin structure at centromeres and subtelomeres by protecting these regions from euchromatin assembly. Enhances the nucleotide exchange activity of the pim1 guanine nucleotide exchange factor and abolishes histone-H3- mediated RanGAP inhibition. Involved in the construction of the centromeres.


ensembl_gene_id: O42862
symbol: atg14
gene_biotype: protein_coding
description:
  Autophagy-related protein 14; Required for cytoplasm to vacuole transport (Cvt) and autophagy as a part of the autophagy-specific vps34 PI3-kinase complex I. This complex is essential to recruit the atg8-phosphatidylinositol conjugate and the atg12-atg5 conjugate to the preautophagosomal structure. Atg14 mediates the specific binding of the vps34 PI3-kinase complex I to the preautophagosomal structure (PAS) (By similarity).


ensembl_gene_id: O42866
symbol: oar2
gene_biotype: protein_coding
description:
  3-oxoacyl-[acyl-carrier-protein] reductase; Involved in biosynthesis of fatty acids in mitochondria. Belongs to the short-chain dehydrogenases/reductases (SDR) family.


ensembl_gene_id: O42868
symbol: ssu72
gene_biotype: protein_coding
description:
  RNA polymerase II subunit A C-terminal domain phosphatase ssu72; Processively dephosphorylates Ser-5 of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (rpb1); Belongs to the SSU72 phosphatase family.


ensembl_gene_id: O42871
symbol: png1
gene_biotype: protein_coding
description:
  Chromatin modification-related protein png1; Component of a histone deacetylase complex responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Has a role in silencing of mating type genes.


ensembl_gene_id: O42872
symbol: rrp41
gene_biotype: protein_coding
description:
  Exosome complex component ski6; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm [...]


ensembl_gene_id: O42874
symbol: peg1
gene_biotype: protein_coding
description:
  Protein peg1; Microtubule binding protein that regulates the stability of dynamic microtubules. Required for mitotic spindle formation. Belongs to the CLASP family.


ensembl_gene_id: O42877
symbol: fcf2
gene_biotype: protein_coding
description:
  rRNA-processing protein fcf2; Involved in pre-rRNA processing and 40S ribosomal subunit assembly. Required for the early cleavage steps of 35S rRNA at the A(0), A(1), and A(2) sites (By similarity); Belongs to the FCF2 family.


ensembl_gene_id: O42881
symbol: SPAC8E11.04c
gene_biotype: protein_coding
description:
  Acyl-protein thioesterase 1; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins with a strong preference for palmitoylated G-alpha proteins over other acyl substrates.


ensembl_gene_id: O42885
symbol: pho84
gene_biotype: protein_coding
description:
  Putative inorganic phosphate transporter C8E4.01c; High-affinity transporter for external inorganic phosphate. Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.


ensembl_gene_id: O42890
symbol: cao2
gene_biotype: protein_coding
description:
  Copper amine oxidase-like protein cao2; Copper amine oxidase-like protein that does not show any copper amine oxidase activity. May be the appropriate amine substrate for cao2 has not been identified yet; Belongs to the copper/topaquinone oxidase family.


ensembl_gene_id: O42894
symbol: rrp46
gene_biotype: protein_coding
description:
  Exosome complex component rrp46; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplas [...]


ensembl_gene_id: O42897
symbol: rpn3
gene_biotype: protein_coding
description:
  Probable 26S proteasome regulatory subunit rpn3; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.


ensembl_gene_id: O42899
symbol: sco1
gene_biotype: protein_coding
description:
  Protein sco1; Acts as a copper chaperone, transporting copper to the Cu(A) site on the cytochrome c oxidase subunit II (COX2); Belongs to the SCO1/2 family.


ensembl_gene_id: O42900
symbol: vps15
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase ppk19; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.


ensembl_gene_id: O42904
symbol: prp31
gene_biotype: protein_coding
description:
  Pre-mRNA-processing factor 31; Required for spliceosome assembly where it is needed to link the U4/U6XU5 tri-snRNP to the prespliceosome complexes. Belongs to the PRP31 family.


ensembl_gene_id: O42905
symbol: rti1
gene_biotype: protein_coding
description:
  DNA repair and recombination protein rti1; Active in the repair of DNA damage and in mating-type switching. Probably involved in the repair of DNA double-strands breaks. Has a role in promoting S phase completion.


ensembl_gene_id: O42906
symbol: npa3
gene_biotype: protein_coding
description:
  GPN-loop GTPase 1; Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.


ensembl_gene_id: O42908
symbol: cym1
gene_biotype: protein_coding
description:
  Mitochondrial presequence protease; ATP-independent protease that degrades mitochondrial transit peptides after their cleavage. Also degrades other unstructured peptides (By similarity); Belongs to the peptidase M16 family. PreP subfamily.


ensembl_gene_id: O42910
symbol: ppr7
gene_biotype: protein_coding
description:
  Pentatricopeptide repeat-containing protein 7, mitochondrial; Mitochondrial RNA-binding protein required for the stability of the atp6 mRNA.


ensembl_gene_id: O42913
symbol: nrm1
gene_biotype: protein_coding
description:
  Transcription factor nrm1; Negative regulatory component of the MBF complex involved in cell-cycle-dependent transcription; Belongs to the WHI5/NRM1 family.


ensembl_gene_id: O42915
symbol: ufd1
gene_biotype: protein_coding
description:
  Ubiquitin fusion degradation protein 1; Functions at a post-ubiquitation step in the ubiquitin fusion degradation (UFD) pathway. It is required for vegetative growth (By similarity).


ensembl_gene_id: O42916
symbol: ale1
gene_biotype: protein_coding
description:
  Lysophospholipid acyltransferase; Membrane-bound O-acyltransferase that mediates the incorporation of unsaturated acyl chains into the sn-2 position of phospholipids.


ensembl_gene_id: O42917
symbol: eso1
gene_biotype: protein_coding
description:
  N-acetyltransferase eso1; Probable acetyltransferase required for the establishment of sister chromatid cohesion and couple the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. The relevance of acetyltransferase function remains unclear (By similarity). In the N-terminal section; belongs to the DNA polymerase type-Y family.


ensembl_gene_id: O42921
symbol: coa5
gene_biotype: protein_coding
description:
  Mitochondrial protein pet191 homolog; Involved in the assembly of cytochrome c oxidase. Belongs to the PET191 family.


ensembl_gene_id: O42923
symbol: cip1
gene_biotype: protein_coding
description:
  RNA-binding post-transcriptional regulator cip1; Regulates global gene expression after oxidative stress. Interacts and stabilizes mRNAs and may regulate their transition between different cytoplasmic components after oxidative stress.


ensembl_gene_id: O42924
symbol: eaf7
gene_biotype: protein_coding
description:
  Probable chromatin modification-related protein eaf7; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity).


ensembl_gene_id: O42926
symbol: vps1302
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 13b; May be involved in recycling of membrane proteins between an endocytic compartment and the TGN; Belongs to the VPS13 family.


ensembl_gene_id: O42930
symbol: vps10
gene_biotype: protein_coding
description:
  Vacuolar protein sorting/targeting protein 10; Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes multiple rounds of sorting by cycling between the late Golgi and a prevacuolar endosome-like compartment; Belongs to the VPS10-related sortilin family.


ensembl_gene_id: O42931
symbol: rpt1
gene_biotype: protein_coding
description:
  26S proteasome regulatory subunit 7 homolog; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).


ensembl_gene_id: O42932
symbol: qcr6
gene_biotype: protein_coding
description:
  Cytochrome b-c1 complex subunit 6; Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inn [...]


ensembl_gene_id: O42933
symbol: ogm4
gene_biotype: protein_coding
description:
  Dolichyl-phosphate-mannose--protein mannosyltransferase 4; Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. Required for normal cell wall and septum formation.


ensembl_gene_id: O42934
symbol: chp2
gene_biotype: protein_coding
description:
  Chromo domain-containing protein 2; Component of the kinetochore which plays a role in stabilizing microtubules and so allowing accurate chromosome segregation.


ensembl_gene_id: O42936
symbol: las1
gene_biotype: protein_coding
description:
  Pre-rRNA-processing protein las1; Required for both pre-rRNA processing and heterochromatic gene silencing.


ensembl_gene_id: O42937
symbol: sec27
gene_biotype: protein_coding
description:
  Probable coatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity).


ensembl_gene_id: O42938
symbol: pfk1
gene_biotype: protein_coding
description:
  ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. May also have a role in cell cycle regulation.


ensembl_gene_id: O42939
symbol: uba2
gene_biotype: protein_coding
description:
  Ubiquitin-activating enzyme E1-like; The dimeric enzyme acts as a SUMO/pmt3 E1 ligase. It mediates ATP-dependent activation of pmt3 and formation of a thioester with a conserved cysteine residue on aos1 (By similarity).


ensembl_gene_id: O42940
symbol: snd301
gene_biotype: protein_coding
description:
  SRP-independent targeting protein 3 homolog; May function in a SRP (signal recognition particle) and GET (guided entry of tail-anchored proteins) independent pathway for targeting a broad range of substrate proteins to the endoplasmic reticulum. Involved in inorganic phosphate uptake. Also involved in telomere length regulation and maintenance (By similarity). Belongs to the PHO88 family.


ensembl_gene_id: O42941
symbol: cyp7
gene_biotype: protein_coding
description:
  Peptidylprolyl isomerase cyp7; PPIases accelerate the folding of proteins. Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in pre-mRNA splicing; Belongs to the cyclophilin-type PPIase family. CWC27 subfamily.


ensembl_gene_id: O42944
symbol: omh2
gene_biotype: protein_coding
description:
  O-glycoside alpha-1,2-mannosyltransferase homolog 2; Probable mannosyltransferase involved in O-glycosylation of cell wall and secreted proteins; Belongs to the glycosyltransferase 15 family.


ensembl_gene_id: O42945
symbol: prp43
gene_biotype: protein_coding
description:
  Probable pre-mRNA-splicing factor ATP-dependent RNA helicase prp43; Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA.


ensembl_gene_id: O42951
symbol: abz2
gene_biotype: protein_coding
description:
  Putative aminodeoxychorismate lyase; Converts 4-amino-4-deoxychorismate into 4-aminobenzoate (PABA) and pyruvate.


ensembl_gene_id: O42954
symbol: mbx1
gene_biotype: protein_coding
description:
  MADS-box transcription factor 1; Acts as a transcriptional activator with a role in the regulation of mitosis. Regulates septation and the periodic transcription of cdc15.


ensembl_gene_id: O42955
symbol: ppr3
gene_biotype: protein_coding
description:
  Pentatricopeptide repeat-containing protein 3, mitochondrial; RNA-binding protein involved in the specific removal of group I introns in mitochondrial encoded transcripts. Maintains the stability of the small subunit mitochondrial 15S rRNA and thus the expression of the mitochondrial genome.


ensembl_gene_id: O42957
symbol: ulp1
gene_biotype: protein_coding
description:
  Ubiquitin-like-specific protease 1; A cysteine protease that proteolytically removes the C- terminus of pmt3.


ensembl_gene_id: O42958
symbol: pdc2
gene_biotype: protein_coding
description:
  DNA topoisomerase 2-associated protein pat1; Activator of decapping that functions as a general and active mechanism of translational repression and required for P-body formation. Stabilizes the 3' terminus of mRNAs and modulates the rates of mRNA-decapping that occur following deadenylation. Might be required for promoting the formation or the stabilization of the preinitiation translation complexes. Necessary for accurate chromosome transmission during cell division (By similarity); Belongs to the PAT1 family.


ensembl_gene_id: O42962
symbol: cog5
gene_biotype: protein_coding
description:
  Conserved oligomeric Golgi complex subunit 5; Acts as essential component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra- Golgi vesicles and possibly a number of other membrane trafficking events (By similarity).


ensembl_gene_id: O42963
symbol: nup44
gene_biotype: protein_coding
description:
  Nucleoporin nup44; Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope.


ensembl_gene_id: O42964
symbol: iws1
gene_biotype: protein_coding
description:
  Transcription factor iws1; Transcription factor involved in RNA polymerase II transcription regulation. May function in both SPT15/TBP post- recruitment and recruitment steps of transcription (By similarity). Belongs to the IWS1 family.


ensembl_gene_id: O42971
symbol: apc10
gene_biotype: protein_coding
description:
  Anaphase-promoting complex subunit 10; Component of the anaphase-promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. Acts as a positive regulator of the anaphase promoting complex (APC)-cyclosome. Involved in G1 cell cycle arrest in response to n [...]


ensembl_gene_id: O42977
symbol: rtp1
gene_biotype: protein_coding
description:
  RNA polymerase II assembly factor rtp1; Required for the cytoplasmic assembly and the nuclear import of RNA polymerase II.


ensembl_gene_id: O42978
symbol: lsm5
gene_biotype: protein_coding
description:
  U6 snRNA-associated Sm-like protein LSm5; Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner. LSm5 is required for processing of pre-tRNAs, pre-rRNAs and U3 snoRNA (By similarity).


ensembl_gene_id: O42979
symbol: psl1
gene_biotype: protein_coding
description:
  PHO85 cyclin-like protein psl1; Cyclin partner of the cyclin-dependent kinase (CDK) pef1 (PHO85 homolog).


ensembl_gene_id: O42980
symbol: nep1
gene_biotype: protein_coding
description:
  NEDD8-specific protease 1; Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as the pcu1, pcu2 and pcu4 cullins and other proteins.


ensembl_gene_id: O42993
symbol: fkh1
gene_biotype: protein_coding
description:
  Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Has an important role in sexual development and serves as the target for rapamycin action; Belongs to the FKBP-type PPIase family. FKBP1 subfamily.


ensembl_gene_id: O42995
symbol: mis19
gene_biotype: protein_coding
description:
  CENP-A recruiting complex protein mis19; Component of the CENP-A recruiting complex that ensures the integrity of mitotic spindles through maintenance of kinetochore factors mis6/CENP-I and cnp1/CENP-A. Links mis16 and mis18 to recruit CENP-A through interacting with non-sense-mediated mRNA decay (NMD) factors and the SWI/SNF complex. Links also mis18 with the CCAN/mis6/ctf19 complex to promote CENP-A assembly.


ensembl_gene_id: O42998
symbol: sip1
gene_biotype: protein_coding
description:
  Pof6 interactor protein 1; Required for endocytosis. Also involved in cytokinesis and cell division.


ensembl_gene_id: O43000
symbol: liz1
gene_biotype: protein_coding
description:
  Pantothenate transporter liz1; Transports pantothenate into the cell. Belongs to the major facilitator superfamily. Allantoate permease family.


ensembl_gene_id: O43001
symbol: syj1
gene_biotype: protein_coding
description:
  Inositol-1,4,5-trisphosphate 5-phosphatase 1; Controls the cellular levels and subcellular distribution of phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5- bisphosphate. Involved in distinct membrane trafficking and signal transduction pathways. Highly active against a range of soluble and lipid inositol phosphates. Active in dephosphorylating the 5-position of Ins(1,4,5)P3 and Ins(1,3,4,5)P4 and to a lesser extent Ins(1,4,5,6)P4. The enzyme is also active against PI(4,5)P2 presented in sonicated vesicles and Triton mixed micelles, and somewhat less active against PI(3,5) [...]


ensembl_gene_id: O43002
symbol: sbh1
gene_biotype: protein_coding
description:
  Protein transport protein sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum.


ensembl_gene_id: O43003
symbol: mmf1
gene_biotype: protein_coding
description:
  Protein mmf1, mitochondrial; Plays a role in the maintenance of mitochondrial DNA. Belongs to the RutC family.


ensembl_gene_id: O43005
symbol: apl1
gene_biotype: protein_coding
description:
  AP-2 complex subunit beta; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Beta adaptin is a subunit of the plasma membrane adaptor (By similarity).


ensembl_gene_id: O43007
symbol: ade9
gene_biotype: protein_coding
description:
  C-1-tetrahydrofolate synthase, mitochondrial; In the C-terminal section; belongs to the formate-- tetrahydrofolate ligase family.


ensembl_gene_id: O43008
symbol: crs1
gene_biotype: protein_coding
description:
  Meiosis-specific cyclin crs1; Has a role in meiotic chromosome segregation. Belongs to the cyclin family. Cyclin AB subfamily.


ensembl_gene_id: O43010
symbol: myr1
gene_biotype: protein_coding
description:
  Glycylpeptide N-tetradecanoyltransferase; Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins; Belongs to the NMT family.


ensembl_gene_id: O43011
symbol: hrs1
gene_biotype: protein_coding
description:
  Histidine--tRNA ligase, mitochondrial; Catalyzes the aminoacylation of histidyl-tRNA in both the cytoplasm and the mitochondrion.


ensembl_gene_id: O43012
symbol: dcd1
gene_biotype: protein_coding
description:
  Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase. Belongs to the cytidine and deoxycytidylate deaminase family.


ensembl_gene_id: O43014
symbol: mpi1
gene_biotype: protein_coding
description:
  Mannose-6-phosphate isomerase; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions.


ensembl_gene_id: O43015
symbol: psu2
gene_biotype: protein_coding
description:
  Probable secreted beta-glucosidase C2G2.17c; Cell surface beta-glucosidase involved in cell wall biogenesis; Belongs to the SUN family.


ensembl_gene_id: O43022
symbol: rsn1
gene_biotype: protein_coding
description:
  Uncharacterized protein C354.08c; Acts as an osmosensitive calcium-permeable cation channel. Belongs to the CSC1 (TC 1.A.17) family.


ensembl_gene_id: O43026
symbol: gpd3
gene_biotype: protein_coding
description:
  Glyceraldehyde-3-phosphate dehydrogenase 2; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.


ensembl_gene_id: O43028
symbol: vac8
gene_biotype: protein_coding
description:
  Vacuolar protein 8; Functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole; Belongs to the beta-catenin family.


ensembl_gene_id: O43029
symbol: fap1
gene_biotype: protein_coding
description:
  L-pipecolate oxidase; Oxidizes L-pipecolate and L-proline (6,7% of the activity for L-pipecolate); Belongs to the MSOX/MTOX family.


ensembl_gene_id: O43030
symbol: fes1
gene_biotype: protein_coding
description:
  Hsp70 nucleotide exchange factor fes1; Functions as a nucleotide exchange factor (NEF) for Hsp70 chaperones which accelerates the release of ADP. Required for fully efficient Hsp70-mediated folding of proteins (By similarity). Belongs to the FES1 family.


ensembl_gene_id: O43031
symbol: cwf28
gene_biotype: protein_coding
description:
  Pre-mRNA-splicing factor cwf28; Involved in spliceosome maturation and the first step of pre- mRNA splicing.


ensembl_gene_id: O43032
symbol: srp101
gene_biotype: protein_coding
description:
  Signal recognition particle receptor subunit alpha homolog; Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system. GTP hydrolysis may enhance the fidelity of and provide unidirectionality to the targeting reaction (By similarity).


ensembl_gene_id: O43033
symbol: oms1
gene_biotype: protein_coding
description:
  Uncharacterized methyltransferase C3B9.04, mitochondrial; Probable methyltransferase; Belongs to the methyltransferase superfamily. METL family.


ensembl_gene_id: O43035
symbol: atg3
gene_biotype: protein_coding
description:
  Autophagy-related protein 3; E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt) and autophagy. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C- terminal Gly of atg8. The atg12-atg5 conjugate plays a role of an E3 and promotes the transfer of [...]


ensembl_gene_id: O43036
symbol: rpa43
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerase I subunit rpa43; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. May be involved in recruitment of Pol I to rDNA promoters; Belongs to the eukaryotic RPA43 RNA polymerase subunit family.


ensembl_gene_id: O43038
symbol: vps36
gene_biotype: protein_coding
description:
  Vacuolar protein-sorting-associated protein 36; Component of the ESCRT-II complex, which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin plays a central role in endosomal sorting of ubiquitinated cargo proteins by the ESCRT complexes (By similarity). Required for vacuolar sorting of carboxypeptidase S (CPS); Be [...]


ensembl_gene_id: O43040
symbol: ctf1
gene_biotype: protein_coding
description:
  Cleavage and termination factor 1; Component of the cleavage factor I (CF I) involved in pre- mRNA 3'-end processing.


ensembl_gene_id: O43041
symbol: trs23
gene_biotype: protein_coding
description:
  Transport protein particle subunit trs23; TRAPP plays a key role in the late stages of endoplasmic reticulum to Golgi traffic.


ensembl_gene_id: O43042
symbol: mrpl3
gene_biotype: protein_coding
description:
  54S ribosomal protein L3, mitochondrial; Belongs to the ribonuclease III family. Mitochondrion- specific ribosomal protein mL44 subfamily.


ensembl_gene_id: O43043
symbol: scp1
gene_biotype: protein_coding
description:
  Sterol regulatory element-binding protein cleavage-activating protein; Escort protein required for sre1 processing at low sterol as well as oxygen levels. May regulate export of the scp1/sre1 complex from the ER at low sterol or oxygen levels. 4-methyl sterols bound to scp1 may mask an ER-export signal in scp1 leading to retention of the complex in the ER. Release of 4-methyl sterols may trigger a conformational change in the SSC domain of scp1 unmasking the ER export signal leading to recruitment into COPII-coated vesicles, transport to the Golgi complex, proteolytic cleavage of sre1  [...]


ensembl_gene_id: O43044
symbol: nup120
gene_biotype: protein_coding
description:
  Nucleoporin nup120; Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope.


ensembl_gene_id: O43045
symbol: isa2
gene_biotype: protein_coding
description:
  Iron-sulfur assembly protein 2; Involved in the assembly of mitochondrial and cytoplasmic iron-sulfur proteins. Probably involved in the binding of an intermediate of Fe/S cluster assembly (By similarity); Belongs to the HesB/IscA family.


ensembl_gene_id: O43046
symbol: vma7
gene_biotype: protein_coding
description:
  V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells (By similarity).


ensembl_gene_id: O43047
symbol: mge1
gene_biotype: protein_coding
description:
  GrpE protein homolog, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of ssc1 to substrate proteins (By similarity).


ensembl_gene_id: O43048
symbol: SPBC215.01
gene_biotype: protein_coding
description:
  TBC domain-containing protein C215.01; May act as a GTPase-activating protein for Rab family protein(s).


ensembl_gene_id: O43049
symbol: SPBC3F6.01c
gene_biotype: protein_coding
description:
  Serine/threonine-protein phosphatase T; Protein phosphatase that specifically binds to and dephosphorylates the molecular chaperone Hsp90. Dephosphorylation positively regulates the Hsp90 chaperone machinery (By similarity). Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.


ensembl_gene_id: O43051
symbol: nop14
gene_biotype: protein_coding
description:
  Probable nucleolar complex protein 14; Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity).


ensembl_gene_id: O43052
symbol: rga1
gene_biotype: protein_coding
description:
  Rho-type GTPase-activating protein 1; GTPase-activating protein for Rho1. Involved in the F-actin patch localization, cell morphogenesis, regulation of septation, and cell wall synthesis.


ensembl_gene_id: O43053
symbol: alg6
gene_biotype: protein_coding
description:
  Probable dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase; Adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol (By similarity); Belongs to the ALG6/ALG8 glucosyltransferase family.


ensembl_gene_id: O43057
symbol: dss4
gene_biotype: protein_coding
description:
  Guanine nucleotide exchange factor MSS4 homolog; Guanine-nucleotide-releasing protein that acts on members of the sec4/ypt1/rab subfamily.


ensembl_gene_id: O43058
symbol: sep1
gene_biotype: protein_coding
description:
  Forkhead protein sep1; Required for promoter sequence element PCB-driven, M-phase- specific transcription. Acts as a transcriptional activator with a role in the regulation of mitosis. Regulates septation and the periodic transcription of cdc15.


ensembl_gene_id: O43059
symbol: syp1
gene_biotype: protein_coding
description:
  Cytoskeletal protein syp1; Multi-functional protein that contributes to the endocytic process, but also to events that occur at the neck during cytokinesis. Plays a role as an endocytic adapters with membrane-tubulation activity that associates with transmembrane cargo proteins and initiates the formation of endocytic sites. Contributes to the stabilization of the nascent clathrin-coated pit. Plays also a role in late endocytosis by mediating vesiculation. Involved in the regulation of cell cycle- dependent dynamics of the septin cytoskeleton by promoting septin turnover in different c [...]


ensembl_gene_id: O43060
symbol: tif306
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 3 subunit F; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.


ensembl_gene_id: O43063
symbol: pre3
gene_biotype: protein_coding
description:
  Probable proteasome subunit beta type-1; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity); Belongs to the peptidase T1B family.


ensembl_gene_id: O43065
symbol: mot1
gene_biotype: protein_coding
description:
  Probable helicase mot1; Regulates transcription in association with TATA binding protein (TBP). Removes TBP from the TATA box via its ATPase activity (By similarity).


ensembl_gene_id: O43068
symbol: mde4
gene_biotype: protein_coding
description:
  Monopolin complex subunit mde4; The monopolin-like pcs1/mde4 complex is essential for accurate chromosome segregation during mitosis and meiosis II. May clamp together microtubule binding sites on the same kinetochore, preventing merotelic attachment of microtubules.


ensembl_gene_id: O43069
symbol: atg7
gene_biotype: protein_coding
description:
  Ubiquitin-like modifier-activating enzyme atg7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates atg12 for its conjugation with atg5 and atg8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the atg8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy wh [...]


ensembl_gene_id: O43070
symbol: nbs1
gene_biotype: protein_coding
description:
  DNA repair and telomere maintenance protein nbs1; Required for DNA damage repair and S-phase DNA damage checkpoint. Involved in telomere length maintenance and maintenance of chromatin structure.


ensembl_gene_id: O43071
symbol: prp17
gene_biotype: protein_coding
description:
  Pre-mRNA-processing factor 17; Functions in the second step of pre-mRNA splicing. Involved in splicing intron which are longer than 200 nucleotides.


ensembl_gene_id: O43076
symbol: shq1
gene_biotype: protein_coding
description:
  Protein shq1; Involved in the early biogenesis steps of box H/ACA snoRNP assembly; Belongs to the SHQ1 family.


ensembl_gene_id: O43079
symbol: apl2
gene_biotype: protein_coding
description:
  AP-1 complex subunit beta-1; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. The AP-1 complex interacts directly with clathrin (By similarity).


ensembl_gene_id: O43082
symbol: rrp1402
gene_biotype: protein_coding
description:
  Ribosomal RNA-processing protein 14-C; Involved in ribosome biogenesis and cell polarity. Required for the synthesis of both 40S and 60S ribosomal subunits and may also play some direct role in correct positioning of the mitotic spindle during mitosis (By similarity).


ensembl_gene_id: O43083
symbol: hip4
gene_biotype: protein_coding
description:
  Histone promoter control protein 2; Component of the HIR complex, which functions as a histone chaperone that cooperates with cia1/asf1 to promote replication- independent chromatin assembly.


ensembl_gene_id: O43084
symbol: hsp3103
gene_biotype: protein_coding
description:
  Probable glutathione-independent glyoxalase hsp3103; Catalyzes the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step. May play a role in detoxifying endogenously produced glyoxals. Involved in protection against reactive oxygen species (ROS); Belongs to the peptidase C56 family. HSP31-like subfamily.


ensembl_gene_id: O43085
symbol: dsc1
gene_biotype: protein_coding
description:
  DSC E3 ubiquitin ligase complex subunit 1; Catalytic component of the DSC E3 ubiquitin ligase complex which is required for the sre1 transcriptional activator proteolytic cleavage to release the soluble transcription factor from the membrane in low oxygen or sterol conditions. The complex plays also an important role in the multivesicular body (MVB) pathway and functions in a post- endoplasmic reticulum pathway for protein degradation.


ensembl_gene_id: O43086
symbol: elg1
gene_biotype: protein_coding
description:
  Telomere length regulation protein elg1; Involved in the negative control of telomere length and in telomeric silencing through a replication-mediated pathway. May have a role in Okazaki fragment maturation. Required for S-phase progression. An RFC-like complex (elg1-RFC) is formed where elg1 replaces rfc1 in the RFC complex. This complex appears to have a role in DNA replication, replication fork re-start, recombination and repair.


ensembl_gene_id: O43088
symbol: rba50
gene_biotype: protein_coding
description:
  RNA polymerase II-associated protein rba50; Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding proteins, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation.


ensembl_gene_id: O43089
symbol: cbp6
gene_biotype: protein_coding
description:
  Cytochrome B pre-mRNA-processing protein 6; Involved in processing of the 5' terminus and the intervening sequences of cytochrome b pre-mRNA.


ensembl_gene_id: O43091
symbol: dps1
gene_biotype: protein_coding
description:
  Decaprenyl-diphosphate synthase subunit 1; Supplies decaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinones ubiquinone-10; Belongs to the FPP/GGPP synthase family.


ensembl_gene_id: O43092
symbol: oxa102
gene_biotype: protein_coding
description:
  Mitochondrial inner membrane protein oxa1-2; Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome c oxidase. It is essential for viability while oxa101 is not. When both are deleted the cell is non-viable, suggesting that oxa101 act as a back-up for oxa102; Belongs to the OXA1/ALB3/YidC family.


ensembl_gene_id: O43114
symbol: orc5
gene_biotype: protein_coding
description:
  Origin recognition complex subunit 5; Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. ORC binds to multiple sites within the ars1 origin of DNA replication in an ATP-independent manner.


ensembl_gene_id: O43120
symbol: uap2
gene_biotype: protein_coding
description:
  Splicing factor U2AF-associated protein 2; Has a role in pre-mRNA splicing. Belongs to the HTATSF1 family.


ensembl_gene_id: O59666
symbol: ccc2
gene_biotype: protein_coding
description:
  Copper-transporting ATPase ccc2; Probably involved in copper transport and in the regulation of cellular copper level. Retrieves copper from the metallochaperone atx1 and incorporates it into trans-Golgi vesicles (By similarity).


ensembl_gene_id: O59669
symbol: vps71
gene_biotype: protein_coding
description:
  SWR1 complex subunit vps71; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant H2A.Z leading to transcriptional regulation of selected genes by chromatin remodeling.


ensembl_gene_id: O59673
symbol: atp14
gene_biotype: protein_coding
description:
  ATP synthase subunit H, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the centr [...]


ensembl_gene_id: O59676
symbol: pdp1
gene_biotype: protein_coding
description:
  PWWP domain-containing protein 1; Necessary for DNA damage checkpoint activation. Required for the association of set9 with chromatin and subsequent methylation of H4K20. Associates with H4K20me1 to increase the concentration of set9 on chromatin to perform H4K20me3. H4K20me3 is mainly enriched at heterochromatin and is required for proper heterochromatin assembly.


ensembl_gene_id: O59679
symbol: gef3
gene_biotype: protein_coding
description:
  Rho guanine nucleotide exchange factor gef3; Has a role in the control of cell polarity and cytokinesis. Involved in bipolar growth and septum formation.


ensembl_gene_id: O59680
symbol: cyt1
gene_biotype: protein_coding
description:
  Cytochrome c1, heme protein, mitochondrial; Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient ove [...]


ensembl_gene_id: O59682
symbol: lcb1
gene_biotype: protein_coding
description:
  Serine palmitoyltransferase 1; Component of serine palmitoyltransferase (SPT), which catalyzes the committed step in the synthesis of sphingolipids, the condensation of serine with palmitoyl CoA to form the long chain base 3-ketosphinganine; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.


ensembl_gene_id: O59683
symbol: mti2
gene_biotype: protein_coding
description:
  Translation initiation factor IF-2, mitochondrial; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity); Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.


ensembl_gene_id: O59701
symbol: cys11
gene_biotype: protein_coding
description:
  Cysteine synthase 1; Catalyzes the conversion of O-succinyl-L-serine into cysteine, the last step in the cysteine biosynthesis pathway. Can also use O-acetyl-L-serine ; Belongs to the cysteine synthase/cystathionine beta- synthase family.


ensembl_gene_id: O59702
symbol: clr6
gene_biotype: protein_coding
description:
  Histone deacetylase clr6; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Has a role in chromatin assembly and chromosome segregation.


ensembl_gene_id: O59703
symbol: spo9
gene_biotype: protein_coding
description:
  Geranylgeranyl pyrophosphate synthase; Catalyzes the trans-addition of the 3 molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate. Required for the membrane attachment of ypt7 and rhb1. May be involved in vesicle trafficking and protein sorting. Required for forespore membrane formation. Belongs to the FPP/GGPP synthase family.


ensembl_gene_id: O59704
symbol: elp1
gene_biotype: protein_coding
description:
  Elongator complex protein 1; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation (By similarity). The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5- carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs ; Belongs to the ELP1/IKA1 family.


ensembl_gene_id: O59706
symbol: sap61
gene_biotype: protein_coding
description:
  Pre-mRNA-splicing factor sap61; Involved in mRNA splicing where it associates with cdc5 and the other cwf proteins as part of the spliceosome.


ensembl_gene_id: O59707
symbol: ups2
gene_biotype: protein_coding
description:
  UPS-like protein C36.10; Required for mitochondrial morphology. May control phospholipid metabolism in the mitochondrial intermembrane space (By similarity); Belongs to the slowmo family.


ensembl_gene_id: O59709
symbol: git7
gene_biotype: protein_coding
description:
  Glucose-insensitive transcription protein 7; Involved in cyclic AMP (cAMP) pathway, possibly by participating in the assembly or the conformational activation of specific multiprotein complexes.


ensembl_gene_id: O59710
symbol: arh1
gene_biotype: protein_coding
description:
  Probable NADPH:adrenodoxin oxidoreductase, mitochondrial; Serves as the first electron transfer protein in all the mitochondrial P450 systems.


ensembl_gene_id: O59711
symbol: lys9
gene_biotype: protein_coding
description:
  Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]; Belongs to the saccharopine dehydrogenase family.


ensembl_gene_id: O59713
symbol: dph1
gene_biotype: protein_coding
description:
  2-(3-amino-3-carboxypropyl)histidine synthase subunit 1; Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2. Belongs to the DPH1/DPH2 family. DPH1 subfamily.


ensembl_gene_id: O59715
symbol: dsd1
gene_biotype: protein_coding
description:
  Sphingolipid delta(4)-desaturase; Delta(4)-fatty-acid desaturase which introduces a double bond at the 4-position in the long-chain base (LCB) of ceramides. Required for sphingosine biosynthesis.


ensembl_gene_id: O59718
symbol: nem1
gene_biotype: protein_coding
description:
  Nuclear envelope morphology protein 1; Catalytic component of the nem1-spo7 complex which acts as a phosphatase and may be required for proper nuclear membrane morphology.


ensembl_gene_id: O59721
symbol: pus4
gene_biotype: protein_coding
description:
  tRNA pseudouridine synthase 4; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs. Also catalyzes pseudouridylation of mRNAs with the consensus sequence 5'-GGUUCRA-3'. Belongs to the pseudouridine synthase TruB family.


ensembl_gene_id: O59722
symbol: fab1
gene_biotype: protein_coding
description:
  1-phosphatidylinositol 3-phosphate 5-kinase fab1; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (By similarity). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. The product of the reaction it catalyzes functions as an important regulator of vacuole homeostasis perhaps by controlling membrane flux to and/or from the vacuole (By s [...]


ensembl_gene_id: O59725
symbol: mic60
gene_biotype: protein_coding
description:
  MICOS complex subunit mic60; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway (By similarity).


ensembl_gene_id: O59726
symbol: fnx2
gene_biotype: protein_coding
description:
  Vacuolar membrane amino acid uptake transporter fnx2; MFS-type transporter involved in vacuolar amino acid uptake. Belongs to the major facilitator superfamily.


ensembl_gene_id: O59730
symbol: fma1
gene_biotype: protein_coding
description:
  Methionine aminopeptidase 1; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val).


ensembl_gene_id: O59734
symbol: smf1
gene_biotype: protein_coding
description:
  Small nuclear ribonucleoprotein F; Involved in pre-mRNA splicing. Binds snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site (By similarity).


ensembl_gene_id: O59735
symbol: lac1
gene_biotype: protein_coding
description:
  Sphingosine N-acyltransferase lac1; Component of the ceramide synthase complex required for C26- CoA-dependent ceramide synthesis. Facilitates ER-to-Golgi transport of GPI-anchored proteins (By similarity). Has a role in meiosis.


ensembl_gene_id: O59736
symbol: leu3
gene_biotype: protein_coding
description:
  2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate).


ensembl_gene_id: O59737
symbol: gyp1
gene_biotype: protein_coding
description:
  GTPase-activating protein gyp1; Stimulates specifically the GTPase activity of ypt1. Functions on the Golgi as a negative regulator of ypt1 (By similarity).


ensembl_gene_id: O59739
symbol: bag102
gene_biotype: protein_coding
description:
  BAG family molecular chaperone regulator 1B; Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release.


ensembl_gene_id: O59740
symbol: mod5
gene_biotype: protein_coding
description:
  Cell polarity protein mod5; With tea1, acts in a positive-feedback loop in the microtubule-mediated regulation of cell polarity. Involved in the anchoring of tea1 at the cortex as well as the correct localization of tea3.


ensembl_gene_id: O59742
symbol: clu1
gene_biotype: protein_coding
description:
  Clustered mitochondria protein homolog; mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.


ensembl_gene_id: O59747
symbol: pdf1
gene_biotype: protein_coding
description:
  Palmitoyl-protein thioesterase-dolichyl pyrophosphate phosphatase fusion 1; Essential protein. Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during vacuolar degradation. Required for efficient N- glycosylation. Necessary for maintaining optimal levels of dolichol- linked oligosaccharides; In the N-terminal section; belongs to the palmitoyl-protein thioesterase family.


ensembl_gene_id: O59748
symbol: lsc1
gene_biotype: protein_coding
description:
  CTD kinase subunit beta; Cyclin subunit of the CTDK-I complex, which hyperphosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit. As part of the CTDK-I complex, involved in RNA polymerase II transcriptional elongation and pre-mRNA 3'-end processing. Together with ctk3, required for ctk1/lsk1 CTD kinase activation (By similarity). Together with ctk1/lsk1, required for the regulation of cytokinesis by phosphorylating 'Ser-2' residues found in the heptad repeats of the CTD.


ensembl_gene_id: O59751
symbol: klp6
gene_biotype: protein_coding
description:
  Kinesin-like protein 6; Has a role in establishing metaphase during mitosis. Required for chromosome segregation where it generates tension during kinetochore capturing; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily.


ensembl_gene_id: O59753
symbol: rhp14
gene_biotype: protein_coding
description:
  DNA repair protein rad14; Involved in nucleotide excision repair (NER). Functional in repair of ultraviolet radiation induced damages and in mitotic mutation avoidance. Binds damaged DNA. Binds specifically to base-base mismatches or small insertion/deletion loops with unpaired nucleotides. Maintains GT repeat stability. Functions as a part of the short-patch excision repair system.


ensembl_gene_id: O59755
symbol: cut12
gene_biotype: protein_coding
description:
  Spindle pole body-associated protein cut12; Required for bipolar spindle formation. May act as a regulator of the p34cdc2/cyclin B kinase. Required for full activation of the plo1 kinase. However, in cut12.1 cells at restrictive temperature the H1 kinase does rise concomitant with entry into mitosis, indicating that cut12 is not required for activation of p34cdc2/cyclin B. The cut12.s11 allele may promote cdc2-independent phosphorylation of SPB proteins thereby overcoming the requirement for cdc25 in cell cycle progression.


ensembl_gene_id: O59757
symbol: spc7
gene_biotype: protein_coding
description:
  Kinetochore protein spc7; Acts as a component of the NMS (Ndc80-MIND-Spc7) super complex which has a role in kinetochore function during late meiotic prophase and throughout the mitotic cell cycle.


ensembl_gene_id: O59761
symbol: tyw1
gene_biotype: protein_coding
description:
  S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase; Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis (By similarity); Belongs to the TYW1 family.


ensembl_gene_id: O59762
symbol: gnr1
gene_biotype: protein_coding
description:
  Guanine nucleotide-binding protein negative regulator 1; Negatively regulates the pheromone-response pathway. Acts as a structural mimic of the G protein beta subunit thereby interacting with gpa1 which then inhibits gpa1 signaling.


ensembl_gene_id: O59763
symbol: oca2
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase oca2; Overexpression causes cell cycle arrest. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.


ensembl_gene_id: O59767
symbol: mad3
gene_biotype: protein_coding
description:
  Mitotic spindle checkpoint component mad3; Has a role in transducing the anaphase inhibitory signal to the anaphase promoting complex (APC). Forms part of the mad2 feedback control.


ensembl_gene_id: O59768
symbol: vcx1
gene_biotype: protein_coding
description:
  Vacuolar calcium ion transporter; Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole (By similarity); Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.


ensembl_gene_id: O59770
symbol: pre10
gene_biotype: protein_coding
description:
  Probable proteasome subunit alpha type-7; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity); Belongs to the peptidase T1A family.


ensembl_gene_id: O59771
symbol: ura6
gene_biotype: protein_coding
description:
  Uridylate kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and dUMP as phosphate acceptors, but can also use CMP, dCMP and AMP. Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.


ensembl_gene_id: O59772
symbol: sws2
gene_biotype: protein_coding
description:
  37S ribosomal protein subunit sws2, mitochondrial; Belongs to the universal ribosomal protein uS13 family.


ensembl_gene_id: O59773
symbol: vid21
gene_biotype: protein_coding
description:
  Chromatin modification-related protein vid21; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity).


ensembl_gene_id: O59781
symbol: gem1
gene_biotype: protein_coding
description:
  Mitochondrial Rho GTPase 1; Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution.


ensembl_gene_id: O59782
symbol: SPCC320.05
gene_biotype: protein_coding
description:
  Probable sulfate permease C320.05; Possible sulfate transporter; Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.


ensembl_gene_id: O59786
symbol: hem15
gene_biotype: protein_coding
description:
  Ferrochelatase, mitochondrial; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.


ensembl_gene_id: O59787
symbol: srp72
gene_biotype: protein_coding
description:
  Signal recognition particle subunit srp72; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. Binds the 7S RNA only in presence of srp68. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function (By similarity).


ensembl_gene_id: O59790
symbol: ark1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase ark1; Required for the spindle checkpoint attachment response during spindle formation, kinetochore microtubule interactions and chromosome segregation during anaphase. Ark1 activity depends upon cut17 function and phosphorylation. Ark1 with bir1 is required for full-scale association with kinetochores and formation of a complex with mad3. Ark1 is also required for phosphorylation of histone H3 that accompanies chromosome condensation and condensin recruitment to mitotic chromatin. Ark1 with pic1 is required for the execution of cytokinesis.


ensembl_gene_id: O59791
symbol: sry1
gene_biotype: protein_coding
description:
  Serine racemase; Catalyzes the synthesis of D-serine from L-serine. Has dehydratase activity towards both L-serine and D-serine.


ensembl_gene_id: O59792
symbol: cif1
gene_biotype: protein_coding
description:
  Calnexin-independence factor 1; Induces a stably inheritable state of calnexin independence called the Cin state when overexpressed.


ensembl_gene_id: O59793
symbol: bis1
gene_biotype: protein_coding
description:
  Stress response protein bis1; Has a role in maintaining cell viability during stationary phase induced by stress response. May be involved in pre-mRNA splicing; Belongs to the ESS2 family.


ensembl_gene_id: O59796
symbol: vps3
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 3; Required for sorting and processing of soluble vacuolar proteins; Belongs to the VPS3 family.


ensembl_gene_id: O59797
symbol: nap1
gene_biotype: protein_coding
description:
  Putative nucleosome assembly protein C364.06; Belongs to the nucleosome assembly protein (NAP) family.


ensembl_gene_id: O59800
symbol: cwf5
gene_biotype: protein_coding
description:
  Pre-mRNA-splicing factor cwf5; Facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome. Binds to RNA (By similarity). Involved in pre-mRNA splicing; Belongs to the RRM SLT11 family.


ensembl_gene_id: O59801
symbol: ski2
gene_biotype: protein_coding
description:
  Putative ATP-dependent RNA helicase C550.03c; RNA helicase component of the SKI complex involved in 3'-mRNA degradation pathway.


ensembl_gene_id: O59802
symbol: gpi2
gene_biotype: protein_coding
description:
  Phosphatidylinositol N-acetylglucosaminyltransferase GPI2 subunit; Part of the complex catalyzing the transfer of N- acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis; Belongs to the PIGC family.


ensembl_gene_id: O59804
symbol: hsp10
gene_biotype: protein_coding
description:
  10 kDa heat shock protein, mitochondrial; Eukaryotic CPN10 homolog which is essential for mitochondrial protein biogenesis, together with CPN60. Binds to CPN60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity).


ensembl_gene_id: O59811
symbol: rei1
gene_biotype: protein_coding
description:
  Cytoplasmic 60S subunit biogenesis factor SPCC550.15c; Pre-60S-associated factor involved in the cytoplasmic maturation of the 60S subunit. Involved in the dissociation and recycling of other late pre-60S factors before newly synthesized large ribosomal subunits enter translation (By similarity).


ensembl_gene_id: O59812
symbol: gcd1
gene_biotype: protein_coding
description:
  Probable glucose-6-phosphate 1-dehydrogenase C794.01c; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis (By similarity); Belongs to the glucose-6-phosphate dehydrogenase family.


ensembl_gene_id: O59816
symbol: lat1
gene_biotype: protein_coding
description:
  Pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).


ensembl_gene_id: O59819
symbol: ugp1
gene_biotype: protein_coding
description:
  Probable UTP--glucose-1-phosphate uridylyltransferase; Plays a central role as a glucosyl donor in cellular metabolic pathways.


ensembl_gene_id: O59821
symbol: csl4
gene_biotype: protein_coding
description:
  Exosome complex component csl4; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm [...]


ensembl_gene_id: O59823
symbol: vma8
gene_biotype: protein_coding
description:
  V-type proton ATPase subunit D; Subunit of the peripheral V1 complex of vacuolar ATPase. V- ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system; Belongs to the V-ATPase D subunit family.


ensembl_gene_id: O59824
symbol: yme1
gene_biotype: protein_coding
description:
  ATP-dependent zinc metalloprotease YME1 homolog; Putative ATP-dependent protease; In the C-terminal section; belongs to the peptidase M41 family.


ensembl_gene_id: O59825
symbol: thp1
gene_biotype: protein_coding
description:
  G/U mismatch-specific uracil DNA glycosylase; Removes uracil from G/U mispairs in ssDNA. Also corrects G/G mispairs. Does not catalyze the removal of thymine from G/T mispairs.


ensembl_gene_id: O59826
symbol: osr2
gene_biotype: protein_coding
description:
  Putative voltage-gated potassium channel subunit beta; Probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.


ensembl_gene_id: O59832
symbol: dpe2
gene_biotype: protein_coding
description:
  Uncharacterized dipeptidase C965.12; Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.


ensembl_gene_id: O59834
symbol: SPCC965.14c
gene_biotype: protein_coding
description:
  Probable cytosine deaminase; Converts cytosine to uracil or 5-methylcytosine to thymine by deaminating carbon number 4; Belongs to the cytidine and deoxycytidylate deaminase family.


ensembl_gene_id: O59835
symbol: cdm1
gene_biotype: protein_coding
description:
  DNA polymerase delta subunit 4; Appears to have a role in the stabilization of the DNA polymerase delta complex.


ensembl_gene_id: O59836
symbol: dfp1
gene_biotype: protein_coding
description:
  Hsk1-interacting molecule 1; Activates hsk1 kinase and is essential for G1/S transition. Has a role in S-phase checkpoint control induced by replication fork blocks after nucleotide deprivation and DNA damage.


ensembl_gene_id: O59858
symbol: gpx1
gene_biotype: protein_coding
description:
  Glutathione peroxidase-like peroxiredoxin gpx1; Glutathione peroxidase-like protein that protects cells during oxidative stress. Has peroxidase activity reducing hydrogen peroxide, alkyl and phospholipid hydroperoxides using preferentially thioredoxin as a reducing power. May act as a scavenger of H(2)O(2). Belongs to the glutathione peroxidase family.


ensembl_gene_id: O59866
symbol: wbp1
gene_biotype: protein_coding
description:
  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit wbp1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the [...]


ensembl_gene_id: O59868
symbol: pmr1
gene_biotype: protein_coding
description:
  Calcium-transporting ATPase 1; Transports calcium and manganese ions into the cell. Regulates cell morphogenesis through control of manganese and calcium homeostasis.


ensembl_gene_id: O59945
symbol: fim1
gene_biotype: protein_coding
description:
  Fimbrin; Binds to actin, and functionally associates with actin structures involved in the development and maintenance of cell polarity. Plays a role in cytokinesis. Plays important roles in mating and in spore formation.


ensembl_gene_id: O60016
symbol: clr4
gene_biotype: protein_coding
description:
  Histone-lysine N-methyltransferase, H3 lysine-9 specific; Histone methyltransferase. Catalytic component of the rik1- associated E3 ubiquitin ligase complex that shows ubiquitin ligase activity and is required for histone H3K9 methylation. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting swi6/HP1 to methylated histones which leads to transcriptional silencing within centromeric heterochromatin, telomeric regions and at the silent mating-type loci. Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransfer [...]


ensembl_gene_id: O60052
symbol: cwp1
gene_biotype: protein_coding
description:
  Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha; Catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. The alpha subunit is thought to participate in a stable complex with the substrate. The beta subunit binds the peptide substrate.


ensembl_gene_id: O60055
symbol: utp20
gene_biotype: protein_coding
description:
  U3 small nucleolar RNA-associated protein 20; Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.


ensembl_gene_id: O60058
symbol: SPBC56F2.07c
gene_biotype: protein_coding
description:
  ATPase family gene 2 protein; ATP-dependent chaperone which uses the energy provided by ATP hydrolysis to generate mechanical force to disassemble protein complexes. Plays an essential role in the cytoplasmic maturation steps of pre-60S ribosomal particles by promoting the release of shuttling protein rlp24 from the pre-ribosomal particles. This step facilitates the subsequent release of other shuttling proteins such as nog1 and allows the transition of the pre-ribosomal particles to later maturation forms that bind SPCC550.15c/REI1.


ensembl_gene_id: O60064
symbol: mpg2
gene_biotype: protein_coding
description:
  Probable mannose-1-phosphate guanyltransferase; Involved in cell wall synthesis where it is required for glycosylation; Belongs to the transferase hexapeptide repeat family.


ensembl_gene_id: O60065
symbol: pex14
gene_biotype: protein_coding
description:
  Peroxisomal membrane protein pex14; Component of the peroxisomal translocation machinery with pex13 and pex17; Belongs to the peroxin-14 family.


ensembl_gene_id: O60066
symbol: abh1
gene_biotype: protein_coding
description:
  Alpha-ketoglutarate-dependent dioxygenase abh1; Putative dioxygenase that may repair alkylated DNA or RNA by oxidative demethylation. Requires molecular oxygen, alpha-ketoglutarate and iron (By similarity); Belongs to the alkB family.


ensembl_gene_id: O60068
symbol: isd11
gene_biotype: protein_coding
description:
  Protein isd11; Required for mitochondrial iron-sulfur (Fe-S) protein biosynthesis; Belongs to the complex I LYR family.


ensembl_gene_id: O60069
symbol: swf1
gene_biotype: protein_coding
description:
  Palmitoyltransferase swf1; Palmitoyltransferase that targets several endosomal SNAREs. Palmitoylates the SNAREs at cysteine residues close to the cytoplasmic end of their transmembrane domain. May have a role in the cellular quality control of transmembrane domain-containing proteins (By similarity); Belongs to the DHHC palmitoyltransferase family. SWF1 subfamily.


ensembl_gene_id: O60074
symbol: did2
gene_biotype: protein_coding
description:
  Vacuolar protein-sorting-associated protein 46; Class E VPS protein implicated in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles. The lumenal sequestrated membrane proteins will be targeted into the vacuole after fusion of the endosome with the vacuole (By similarity).


ensembl_gene_id: O60076
symbol: taf13
gene_biotype: protein_coding
description:
  Transcription initiation factor TFIID subunit 13; Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of tr [...]


ensembl_gene_id: O60080
symbol: dbp9
gene_biotype: protein_coding
description:
  ATP-dependent RNA helicase dbp9; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs; Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily.


ensembl_gene_id: O60081
symbol: trm732
gene_biotype: protein_coding
description:
  Uncharacterized protein C1494.07; May be involved in the methylation of the 2'-O-ribose of nucleotides at position 32 of the tRNA anticodon loop of tRNA(Phe) and tRNA(Leu(UAA)) by SPAC4F10.03c.


ensembl_gene_id: O60084
symbol: tim44
gene_biotype: protein_coding
description:
  Mitochondrial import inner membrane translocase subunit tim44; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Recruits mitochondrial HSP70 and its co-chaperone (mge1) to drive protein translocation into the matrix using ATP as an energy source.


ensembl_gene_id: O60085
symbol: fma2
gene_biotype: protein_coding
description:
  Methionine aminopeptidase 2; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val); Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.


ensembl_gene_id: O60086
symbol: ilv6
gene_biotype: protein_coding
description:
  Probable acetolactate synthase small subunit; Stimulates activity of the acetolactate synthase catalytic subunit ilv1.


ensembl_gene_id: O60094
symbol: pol5
gene_biotype: protein_coding
description:
  rDNA transcriptional regulator pol5; Plays an important role in the regulation of rRNA transcription. Binds to rDNA promoter fragments. Belongs to the MYBBP1A family.


ensembl_gene_id: O60096
symbol: bot1
gene_biotype: protein_coding
description:
  37S ribosomal protein S35, mitochondrial; Required for mitochondrial protein synthesis. Has a role in mitochondrial integrity and cell respiration.


ensembl_gene_id: O60097
symbol: spt8
gene_biotype: protein_coding
description:
  Transcription factor spt8; Functions as a component of the transcription regulatory histone acetylation (HAT) complex SAGA. SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. At the promoters, SAGA is required for recruitment of the basal transcription machinery (By similarity).


ensembl_gene_id: O60100
symbol: kap123
gene_biotype: protein_coding
description:
  Probable importin subunit beta-4; Required for nuclear protein import, its predominant substrate seems to be ribosomal proteins. Binds to nucleoporins and the GTP-bound form of gsp1 (Ran) (By similarity); Belongs to the importin beta family.


ensembl_gene_id: O60102
symbol: rli1
gene_biotype: protein_coding
description:
  Translation initiation factor rli1; Component of the multifactor complex (MFC) involved in translation initiation. Required for the binding of MFC to the 40S ribosome. Required for the processing and nuclear export of the 60S and 40S ribosomal subunits (By similarity).


ensembl_gene_id: O60103
symbol: doa10
gene_biotype: protein_coding
description:
  ERAD-associated E3 ubiquitin-protein ligase doa10; E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated E2 ligases, and transfers it to substrates promoting their degradation. Mediates the degradation of a broad range of substrates, including endoplasmic reticulum membrane proteins (ERQC), soluble nuclear proteins and soluble cytoplasmic proteins (CytoQC). Component of the doa10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of membrane proteins with misfolded cytoplasmic domains. Als [...]


ensembl_gene_id: O60104
symbol: med7
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 7; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).


ensembl_gene_id: O60107
symbol: snx41
gene_biotype: protein_coding
description:
  Sorting nexin-41; May be required for cytoplasm to vacuole transport (Cvt) and pexophagy (By similarity). Has a role in meiosis.


ensembl_gene_id: O60108
symbol: cbh2
gene_biotype: protein_coding
description:
  CENP-B homolog protein 2; Binds to the central core and core-associated repeat regions of centromeric heterochromatin.


ensembl_gene_id: O60111
symbol: SPBC15C4.02
gene_biotype: protein_coding
description:
  ABC1 family protein MCP2 homolog; Involved in mitochondrial lipid homeostasis. Belongs to the protein kinase superfamily. ADCK protein kinase family.


ensembl_gene_id: O60116
symbol: rbk1
gene_biotype: protein_coding
description:
  Ribokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.


ensembl_gene_id: O60119
symbol: scs2
gene_biotype: protein_coding
description:
  Vesicle-associated membrane protein-associated protein C16G5.05c; Targets proteins containing a FFAT motif to endoplasmic reticulum membranes.


ensembl_gene_id: O60122
symbol: trp4
gene_biotype: protein_coding
description:
  Anthranilate phosphoribosyltransferase; Belongs to the anthranilate phosphoribosyltransferase family.


ensembl_gene_id: O60123
symbol: kex1
gene_biotype: protein_coding
description:
  Pheromone-processing carboxypeptidase kex1; Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).


ensembl_gene_id: O60124
symbol: rrp42
gene_biotype: protein_coding
description:
  Exosome complex component rrp42; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplas [...]


ensembl_gene_id: O60125
symbol: bag101
gene_biotype: protein_coding
description:
  BAG family molecular chaperone regulator 1A; Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release.


ensembl_gene_id: O60126
symbol: top3
gene_biotype: protein_coding
description:
  DNA topoisomerase 3; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)- enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils. Fina [...]


ensembl_gene_id: O60127
symbol: ptf2
gene_biotype: protein_coding
description:
  Pdp3-interacting factor 2; Component of the mst2 complex which is a highly specific H3 lysine 14 (H3K14) acetyltransferase that functions together with gcn5 to regulate global levels of H3K14 acetylation (H3K14ac), critical for DNA damage checkpoint activation.


ensembl_gene_id: O60129
symbol: fkh2
gene_biotype: protein_coding
description:
  Fork head protein homolog 2; Required for promoter sequence element PCB-driven, M-phase- specific transcription. Acts as a transcriptional activator with a role in the regulation of mitosis. Binds, cooperatively with mcm1, the CLB cluster regulatory elements throughout the cell cycle. Regulates the periodic transcription of cdc15 and spo12. Required for the correct timing, positioning and contraction of the division septum.


ensembl_gene_id: O60132
symbol: tea4
gene_biotype: protein_coding
description:
  Tip elongation aberrant protein Tea4; Cell polarity factor essential for the bipolar localization and function of structures containing the cell-end marker tea1 during the normal cell cycle. Regulates cell polarity in complex with tea1 and together with the stress signaling MAPK cascade, contributes to cell polarity maintenance under stress conditions. Required for the localization of for3 at the cell tip specifically during initiation of bipolar growth. During the new end take off (NETO), formation of a protein complex that includes tea1, tea4 and for3 is necessary and sufficient for  [...]


ensembl_gene_id: O60135
symbol: lcf1
gene_biotype: protein_coding
description:
  Long-chain-fatty-acid--CoA ligase 1; Esterification, concomitant with transport, of exogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids. It may supplement intracellular myristoyl-CoA pools from exogenous myristate. Preferentially acts on C12:0-C16:0 fatty acids with myristic and pentadecanic acid (C15:0) having the highest activities (By similarity). Appears to play a role in the maintenance of cell viability during stationary phase.


ensembl_gene_id: O60139
symbol: ubp4
gene_biotype: protein_coding
description:
  Probable ubiquitin carboxyl-terminal hydrolase 4; Has an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Acts late in the proteolytic pathway in conjunction with the 26S proteasome. Plays a role in avoiding DNA overreplication (By similarity); Belongs to the peptidase C19 family.


ensembl_gene_id: O60142
symbol: ppr2
gene_biotype: protein_coding
description:
  Pentatricopeptide repeat-containing protein 2, mitochondrial; Mitochondrial RNA-binding protein that acts as a general translation factor.


ensembl_gene_id: O60149
symbol: vps38
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 38; Involved in endosome-to-Golgi retrograde transport as part of the vps34 PI3-kinase complex II. Mediates the interaction between atg6 and the pik3-ppk19 core complex, leading to the recruitment of atg6 to the membrane (By similarity).


ensembl_gene_id: O60152
symbol: ubr1
gene_biotype: protein_coding
description:
  E3 ubiquitin-protein ligase ubr1; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Belongs to the UBR1 family.


ensembl_gene_id: O60156
symbol: sen34
gene_biotype: protein_coding
description:
  Probable tRNA-splicing endonuclease subunit sen34; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant  [...]


ensembl_gene_id: O60157
symbol: ppm2
gene_biotype: protein_coding
description:
  tRNA wybutosine-synthesizing protein 4; Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. May methylate the carboxyl group of leucine residues to form alpha-leucine ester residues (By similarity); Belongs to the methyltransferase superfamily. LCMT family.


ensembl_gene_id: O60158
symbol: bqt4
gene_biotype: protein_coding
description:
  Bouquet formation protein 4; Connects telomeres to the nuclear envelop (NE) during both vegetative growth and meiosis. This connection ensures clustering of telomeres to the spindle pole body (SPB) when cells enter meiotic prophase.


ensembl_gene_id: O60159
symbol: SPBC19C7.11
gene_biotype: protein_coding
description:
  Putative anion/proton exchange transporter C19C7.11; Anion/proton exchange transporter involved in iron and copper cation homeostasis.


ensembl_gene_id: O60160
symbol: omh1
gene_biotype: protein_coding
description:
  O-glycoside alpha-1,2-mannosyltransferase omh1; Mannosyltransferase involved in O-glycosylation of cell wall and secreted proteins. Plays a major role in extending alpha-1,2-linked mannose in the O-glycan pathway; Belongs to the glycosyltransferase 15 family.


ensembl_gene_id: O60161
symbol: utp4
gene_biotype: protein_coding
description:
  U3 small nucleolar RNA-associated protein 4; Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I together with a subset of U3 proteins required for transcription (t- UTPs) (By similarity).


ensembl_gene_id: O60164
symbol: ppp1
gene_biotype: protein_coding
description:
  Pescadillo homolog; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.


ensembl_gene_id: O60165
symbol: spn7
gene_biotype: protein_coding
description:
  Septin homolog spn7; Septin-like protein involved in the correct orientation of forespore membrane extension during sporulation. Binds phosphatidylinositol 4-phosphate.


ensembl_gene_id: O60166
symbol: nud3
gene_biotype: protein_coding
description:
  Nuclear movement protein nudc; Required for nuclear movement. May interact between microtubules and nuclei and/or may be involved in the generation of force used to move nuclei during interphase (By similarity). Belongs to the nudC family.


ensembl_gene_id: O60171
symbol: taf10
gene_biotype: protein_coding
description:
  Transcription initiation factor TFIID subunit 10; Functions as a component of the DNA-binding general transcription factor complex TFIID and the transcription regulatory histone acetylation (HAT) complexes SAGA and SLIK. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modificati [...]


ensembl_gene_id: O60172
symbol: SPBC21H7.03c
gene_biotype: protein_coding
description:
  Thiamine-repressible acid phosphatase SPBC21H7.03c; May dephosphorylate thiamine phosphates. Belongs to the histidine acid phosphatase family.


ensembl_gene_id: O60173
symbol: dbp7
gene_biotype: protein_coding
description:
  ATP-dependent RNA helicase dbp7; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.


ensembl_gene_id: O60174
symbol: sfc6
gene_biotype: protein_coding
description:
  Transcription factor tau subunit sfc6; TFIIIC mediates tRNA and 5S RNA gene activation by binding to intragenic promoter elements. Upstream of the transcription start site, TFIIIC assembles the initiation complex TFIIIB-TFIIIC-tDNA, which is sufficient for RNA polymerase III recruitment and function. Part of the tauB domain of TFIIIC that binds boxB DNA promoter sites of tRNA and similar genes. Cooperates with sfc3 in DNA binding. Localizes to chromatin insulator sequence without recruiting RNA polymerase III and plays a role in nuclear organization.


ensembl_gene_id: O60178
symbol: nta1
gene_biotype: protein_coding
description:
  Protein N-terminal amidase; Deamidates N-terminal Asn and Gln. Component of a targeting complex in the N-end rule pathway (By similarity); Belongs to the carbon-nitrogen hydrolase superfamily.


ensembl_gene_id: O60179
symbol: utp10
gene_biotype: protein_coding
description:
  U3 small nucleolar RNA-associated protein 10; Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I together with a subset of U3 proteins required for transcription (t- UTPs). Involved in ribosome biosynthesis (By similarity).


ensembl_gene_id: O60180
symbol: arx1
gene_biotype: protein_coding
description:
  Probable metalloprotease arx1; Probable metalloprotease involved in proper assembly of pre- ribosomal particles during the biogenesis of the 60S ribosomal subunit. Accompanies the pre-60S particles to the cytoplasm (By similarity).


ensembl_gene_id: O60181
symbol: rib3
gene_biotype: protein_coding
description:
  3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family.


ensembl_gene_id: O60182
symbol: rfc1
gene_biotype: protein_coding
description:
  Replication factor C subunit 1; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. Subunit 1 is essential for cell cycle progression. It may associate with components of the DNA replication machinery and serve to enhance the efficiency of DNA replication.


ensembl_gene_id: O60184
symbol: ssn6
gene_biotype: protein_coding
description:
  General transcriptional corepressor ssn6; Acts as component of the ssn6-tup corepressor complexes, which are involved in the repression of many genes in a wide variety of physiological processes. May also be involved in the derepression of at least some target genes. The complex is recruited to target genes by interaction with DNA-bound transcriptional repressors. The complex recruits histone deacetylases to produce a repressive chromatin structure, interacts with hypoacetylated N-terminal tails of histones H3 and H4 that have been programmed for repression by the action of histone dea [...]


ensembl_gene_id: O60185
symbol: mri1
gene_biotype: protein_coding
description:
  Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.


ensembl_gene_id: O60186
symbol: rsm10
gene_biotype: protein_coding
description:
  37S ribosomal protein S10, mitochondrial; Involved in mitochondrial genome encoded proteins translation. Involved in the binding of tRNA to the ribosomes (By similarity).


ensembl_gene_id: O60187
symbol: sid4
gene_biotype: protein_coding
description:
  Septation initiation protein sid4; Required for activation of the spg1 GTPase signaling cascade which leads to the initiation of septation and the subsequent termination of mitosis. May act as a scaffold at the spindle pole body to which other components of the spg1 signaling cascade attach.


ensembl_gene_id: O60188
symbol: utp6
gene_biotype: protein_coding
description:
  U3 small nucleolar RNA-associated protein 6; Component of the SSU processome, a pre-ribosomal particle required for the maturation of the 18S rRNA from the 35S pre-rRNA precursor.


ensembl_gene_id: O60198
symbol: sam1
gene_biotype: protein_coding
description:
  S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.


ensembl_gene_id: O74113
symbol: cdc45
gene_biotype: protein_coding
description:
  Cell division control protein 45 homolog; Required for initiation of chromosomal DNA replication. May have a role in regulating the MCM proteins nda1 and nda4. Belongs to the CDC45 family.


ensembl_gene_id: O74135
symbol: cki3
gene_biotype: protein_coding
description:
  Casein kinase I homolog 3; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates.


ensembl_gene_id: O74173
symbol: tef5
gene_biotype: protein_coding
description:
  Elongation factor 1-beta; EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP; Belongs to the EF-1-beta/EF-1-delta family.


ensembl_gene_id: O74174
symbol: vma10
gene_biotype: protein_coding
description:
  V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.


ensembl_gene_id: O74184
symbol: pop3
gene_biotype: protein_coding
description:
  Target of rapamycin complex subunit wat1; component of both TORC1 and TORC2, which regulate multiple cellular processes to control cell growth in response to environmental signals. Nutrient limitation and environmental stress signals cause inactivation of TORC1. Active TORC1 positively controls cell growth and ribosome biogenesis by regulating ribosomal protein gene expression. TORC1 negatively controls G1 cell-cycle arrest, sexual development and amino acid uptake. Represses mating, meiosis and sporulation efficiency by interfering with the functions of the transcription factor ste11  [...]


ensembl_gene_id: O74191
symbol: ani1
gene_biotype: protein_coding
description:
  FK506-binding protein 39 kDa; PPIase that acts as a histone chaperone. Histone proline isomerase that increases the rate of cis-trans isomerization at prolines on the histone H3 N-terminal tail. Proline isomerization influences H3 methylation thereby regulating gene expression (By similarity).


ensembl_gene_id: O74215
symbol: dak2
gene_biotype: protein_coding
description:
  Dihydroxyacetone kinase 2; Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde.


ensembl_gene_id: O74304
symbol: win1
gene_biotype: protein_coding
description:
  MAP kinase kinase kinase win1; Involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Activates the wis1 MAP kinase kinase by phosphorylation.


ensembl_gene_id: O74306
symbol: rpl502
gene_biotype: protein_coding
description:
  60S ribosomal protein L5-B; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome throug [...]


ensembl_gene_id: O74309
symbol: slm9
gene_biotype: protein_coding
description:
  Histone transcription regulator slm9; Probably required for replication-independent chromatin assembly (By similarity). Required for transcriptional silencing in the outer repeat (otr) centromeric repeats and the Tf2 long terminal repeat retrotransposons. May play an indirect role in the regulation of cdc2 and/or wee1 at the G2/M stage of mitosis. Belongs to the WD repeat HIR1 family.


ensembl_gene_id: O74310
symbol: zng1
gene_biotype: protein_coding
description:
  COBW domain-containing protein C15D4.05; Belongs to the SIMIBI class G3E GTPase family. CobW subfamily.


ensembl_gene_id: O74312
symbol: atg9
gene_biotype: protein_coding
description:
  Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Required for mitophagy. Cycles between the PAS and the cytoplasmic vesicle pool and may participate in supplying membrane for the growing autophagosome. Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. Different machinerie [...]


ensembl_gene_id: O74314
symbol: met3
gene_biotype: protein_coding
description:
  Probable cystathionine gamma-synthase; Catalyzes the formation of L-cystathionine from O-succinyl-L- homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction. In the absence of thiol, catalyzes gamma-elimination to form 2- oxobutanoate, succinate and ammonia (By similarity).


ensembl_gene_id: O74315
symbol: amo1
gene_biotype: protein_coding
description:
  Nucleoporin-like protein amo1; Involved in the cell polarity process where it is required for the correct termination of microtubule growth at the cell ends during interphase.


ensembl_gene_id: O74319
symbol: taf51
gene_biotype: protein_coding
description:
  Transcription initiation factor TFIID subunit taf73; TAFs are components of the transcription factor IID (TFIID) complex that are essential for mediating regulation of RNA polymerase transcription. Regulates the genes involved in ubiquitin-dependent proteolysis during the progression of M-phase of mitosis.


ensembl_gene_id: O74323
symbol: sec11
gene_biotype: protein_coding
description:
  Signal peptidase complex catalytic subunit sec11; Catalytic component of the signal peptidase complex (SPC), which catalyzes the cleavage of N-terminal signal sequences of proteins targeted to the endoplasmic reticulum. Signal peptide cleavage occurs during the translocation (cotranslationally or post-translationally) through the translocon pore into the endoplasmic reticulum (By similarity).


ensembl_gene_id: O74327
symbol: avt5
gene_biotype: protein_coding
description:
  Vacuolar amino acid transporter 5; Vacuolar amino acid transporter involved in the vacuolar uptake of histidine, glutamate, tyrosine, arginine, lysine, and serine. Required for sporulation; Belongs to the amino acid/polyamine transporter 2 family.


ensembl_gene_id: O74331
symbol: rlp1
gene_biotype: protein_coding
description:
  DNA repair protein rlp1; Required for normal levels of meiotic recombination. Acts in the recombinational pathway of double-strand break (DSB) repair together with rhp51, rhp55 and rad22. Required for the full extent of DNA recombination and cell survival under condition of a replication fork collapse; Belongs to the RecA family. RAD51 subfamily.


ensembl_gene_id: O74333
symbol: fhn1
gene_biotype: protein_coding
description:
  Non-classical export protein 2 homolog; Involved in membrane organization and might act as a sensor of sphingolipids that regulates plasma membrane function. Involved in a novel pathway of export of proteins that lack a cleavable signal sequence; Belongs to the NCE102 family.


ensembl_gene_id: O74335
symbol: rga5
gene_biotype: protein_coding
description:
  Rho-GTPase-activating protein 5; GTPase-activating protein for Rho1. Has a role in the negative regulation of (1-3)beta-D-glucan synthase activity and cell integrity.


ensembl_gene_id: O74338
symbol: blt1
gene_biotype: protein_coding
description:
  Mitosis inducer protein blt1; At the onset of mitosis, forms a medial ring structure before the arrangement of the medial actin ring. Essential for the central positioning of the division septum before the cell divides.


ensembl_gene_id: O74339
symbol: tam41
gene_biotype: protein_coding
description:
  Phosphatidate cytidylyltransferase, mitochondrial; Catalyzes the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA) in the mitochondrial inner membrane. Required for the biosynthesis of the dimeric phospholipid cardiolipin, which stabilizes supercomplexes of the mitochondrial respiratory chain in the mitochondrial inner membrane.


ensembl_gene_id: O74341
symbol: cct3
gene_biotype: protein_coding
description:
  T-complex protein 1 subunit gamma; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity).


ensembl_gene_id: O74343
symbol: pus7
gene_biotype: protein_coding
description:
  Multisubstrate pseudouridine synthase 7; Catalyzes pseudouridylation at position 35 in U2 snRNA stem- loop II region which induces particular conformation of the mRNA-U2 snRNA duplex and places the nucleophile in an accessible position for the first step of splicing. Also catalyzes pseudouridylation at position 56 in U2 snRNA. Catalyzes also pseudouridylation at position 50 in 5S rRNA, position 13 in cytoplasmic tRNAs, and position 35 in pre-tRNA(Tyr). Pseudouridine residues in tRNAs may stabilize the local RNA conformation, favor interactions with protein partners and play an importan [...]


ensembl_gene_id: O74346
symbol: map4
gene_biotype: protein_coding
description:
  P cell-type agglutination protein map4; P cell-type specific protein which involved in agglutination during conjugation.


ensembl_gene_id: O74347
symbol: cmc1
gene_biotype: protein_coding
description:
  COX assembly mitochondrial protein 1; Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration.


ensembl_gene_id: O74349
symbol: rkr1
gene_biotype: protein_coding
description:
  E3 ubiquitin-protein ligase listerin; E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Ubiquitination leads to cdc48 recruitment for extraction and degradation of the incomplete translation product.


ensembl_gene_id: O74350
symbol: bdc1
gene_biotype: protein_coding
description:
  Bromodomain-containing protein 1; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.


ensembl_gene_id: O74351
symbol: nfs1
gene_biotype: protein_coding
description:
  Probable cysteine desulfurase, mitochondrial; Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron-sulfur (Fe- S) clusters. Plays a role in both tRNA-processing and mitochondrial metabolism. Involved in the 2-thio-modification of both 5- carboxymethylaminomethyl-2-thiouridine in mitochondrial tRNAs and 5- methoxycarbonylmethyl-2-thiouridine (mcm5s2U) in cytoplasmic tRNAs. Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.


ensembl_gene_id: O74354
symbol: dnt1
gene_biotype: protein_coding
description:
  Nucleolar protein dnt1; Negatively regulates the septation initiation network (SIN) pathway, independently of the cdc14 phosphatase clp1. May also have a role in silencing rDNA transcription. Required for maintaining the exclusive nucleolus localization of nuc1.


ensembl_gene_id: O74358
symbol: apc13
gene_biotype: protein_coding
description:
  Anaphase-promoting complex subunit 13; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome.


ensembl_gene_id: O74362
symbol: esf2
gene_biotype: protein_coding
description:
  Pre-rRNA-processing protein esf2; Involved in the small subunit (SSU) processome assembly and function, and in the 18S rRNA synthesis. Required for the early cleavages at sites A0, A1 and A2 (By similarity); Belongs to the ESF2/ABP1 family.


ensembl_gene_id: O74364
symbol: ldb1
gene_biotype: protein_coding
description:
  Adhesion defective protein 1; Probable transcriptional regulator involved in cell adhesion. Belongs to the adn1/SEU family.


ensembl_gene_id: O74365
symbol: sol1
gene_biotype: protein_coding
description:
  SWI/SNF chromatin-remodeling complex subunit sol1; Component of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors.


ensembl_gene_id: O74366
symbol: tfb4
gene_biotype: protein_coding
description:
  General transcription and DNA repair factor IIH subunit tfb4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has be [...]


ensembl_gene_id: O74368
symbol: mmm1
gene_biotype: protein_coding
description:
  Maintenance of mitochondrial morphology protein 1; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. The mdm12-mmm1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta- barrel proteins, and acts in a late step after the SAM complex. The mdm10-mdm12-mmm1 su [...]


ensembl_gene_id: O74369
symbol: css1
gene_biotype: protein_coding
description:
  Inositol phosphosphingolipids phospholipase C; Inositol phosphosphingolipids phospholipase essential for the coordination of cell wall formation. Responsible for the hydrolysis of the phosphosphingolipids (IPS), inositol phosphorylceramide (IPC), mannosylinositol phosphorylceramide (MIPC), and mannosyldiinositol phosphorylceramide (M(IP)2C); Belongs to the neutral sphingomyelinase family.


ensembl_gene_id: O74370
symbol: cwf12
gene_biotype: protein_coding
description:
  Pre-mRNA-splicing factor cwf12; Involved in mRNA splicing and cell cycle control; Belongs to the ISY1 family.


ensembl_gene_id: O74372
symbol: duo1
gene_biotype: protein_coding
description:
  DASH complex subunit duo1; Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity).


ensembl_gene_id: O74374
symbol: pgm1
gene_biotype: protein_coding
description:
  Phosphoglucomutase; Catalyzes the reversible interconversion of glucose 1- phosphate and glucose 6-phosphate. Key enzyme in hexose metabolism. The reverse reaction is an essential step for biosynthesis because glucose 1-phosphate is the starting point for the synthesis of UDP-glucose, which acts as a precursor for the synthesis of oligosaccharides and trehalose; Belongs to the phosphohexose mutase family.


ensembl_gene_id: O74375
symbol: SPBC32F12.12c
gene_biotype: protein_coding
description:
  Golgi apparatus membrane protein tvp18; Golgi membrane protein involved in vesicular trafficking. Belongs to the TVP18 family.


ensembl_gene_id: O74377
symbol: sul1
gene_biotype: protein_coding
description:
  Probable sulfate permease C3H7.02; High affinity uptake of sulfate into the cell; Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.


ensembl_gene_id: O74378
symbol: kgd1
gene_biotype: protein_coding
description:
  2-oxoglutarate dehydrogenase, mitochondrial; The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).


ensembl_gene_id: O74384
symbol: erf2
gene_biotype: protein_coding
description:
  Palmitoyltransferase erf2; The erf2-erf4 complex is a palmitoyltransferase specific for Ras proteins (By similarity). Has a role in sporulation; Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.


ensembl_gene_id: O74385
symbol: elp6
gene_biotype: protein_coding
description:
  Elongator complex protein 6 homolog; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation (By similarity). The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5- carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs ; Belongs to the ELP6 family.


ensembl_gene_id: O74386
symbol: trm141
gene_biotype: protein_coding
description:
  Uncharacterized methyltransferase C3H7.11; Probable methyltransferase; Belongs to the methyltransferase superfamily. METL family.


ensembl_gene_id: O74387
symbol: rav2
gene_biotype: protein_coding
description:
  Regulator of V-ATPase in vacuolar membrane protein 2; Component of the RAVE complex which is required for stable assembly of the vacuolar ATPase complex V-ATPase.


ensembl_gene_id: O74391
symbol: rpl2502
gene_biotype: protein_coding
description:
  60S ribosomal protein L25-B; This protein binds to a specific region on the 26S rRNA. Belongs to the universal ribosomal protein uL23 family.


ensembl_gene_id: O74393
symbol: mak5
gene_biotype: protein_coding
description:
  ATP-dependent RNA helicase mak5; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs; Belongs to the DEAD box helicase family. DDX24/MAK5 subfamily.


ensembl_gene_id: O74395
symbol: str1
gene_biotype: protein_coding
description:
  Siderophore iron transporter 1; Involved in the transport of siderophore iron and so has a role in iron homeostasis; Belongs to the major facilitator superfamily.


ensembl_gene_id: O74396
symbol: vps901
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 9a; Required for vacuolar protein sorting; may be required for the consumption of transport vesicles containing vacuolar protein precursors.


ensembl_gene_id: O74399
symbol: erb1
gene_biotype: protein_coding
description:
  Ribosome biogenesis protein erb1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.


ensembl_gene_id: O74401
symbol: ero11
gene_biotype: protein_coding
description:
  ERO1-like protein 1; Essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. Acts by oxidizing directly pdi1 isomerase through a direct disulfide exchange. Does not act as a direct oxidant of folding substrate, but relies on pdi1 to transfer oxidizing equivalent. Does not oxidize all pdi related proteins, suggesting that it can discriminate between pdi1 and related proteins. Its reoxidation probably involves electron transfer to molecular oxygen via FAD. Acts independently of glutathione. May be responsible for a significant proportion o [...]


ensembl_gene_id: O74402
symbol: hsp78
gene_biotype: protein_coding
description:
  Heat shock protein 78, mitochondrial; Required, in concert with mitochondrial Hsp70, for the dissociation, resolubilization and refolding of aggregates of damaged proteins in the mitochondrial matrix after heat stress. May extract proteins from aggregates by unfolding and threading them in an ATP- dependent process through the axial channel of the protein hexamer, after which they can be refolded by the Hsp70 chaperone system. Required for resumption of mitochondrial respiratory function, DNA synthesis and morphology after heat stress (By similarity). Belongs to the ClpA/ClpB family.


ensembl_gene_id: O74405
symbol: set11
gene_biotype: protein_coding
description:
  Ribosomal lysine N-methyltransferase set11; S-adenosyl-L-methionine-dependent protein-lysine N- methyltransferase that trimethylates 60S ribosomal protein L12 (rpl1201 and rpl1202) at 'Lys-4' and may dimethylate L12 also at 'Lys-40' and 'Lys-41'. Overexpression causes a severe growth defect. Has a role in meiosis; Belongs to the class V-like SAM-binding methyltransferase superfamily. RKM2 family.


ensembl_gene_id: O74409
symbol: uro1
gene_biotype: protein_coding
description:
  Uricase; Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin. Belongs to the uricase family.


ensembl_gene_id: O74411
symbol: meu10
gene_biotype: protein_coding
description:
  Meiotic expression up-regulated protein 10; Required for the formation of the mature spore wall, where it is needed to ensure correct localization of 1,3-beta-glucan.


ensembl_gene_id: O74412
symbol: cbf12
gene_biotype: protein_coding
description:
  Transcription factor cbf12; Transcription factor which function may be to trigger the increase of adhesion at stationary phase, possibly by counteracting or replacing cbf11 at the respective promoters. May also play a cbf11- antagonistic role in the regulation of a number of other important processes such as extracellular material production, colony morphogenesis, ploidy maintenance, or meiosis.


ensembl_gene_id: O74416
symbol: ump1
gene_biotype: protein_coding
description:
  Probable proteasome maturation factor ump1; Short-lived chaperone present in the precursor form of the 20S proteasome and absent in the mature complex. Required for the correct assembly and enzymatic activation of the proteasome (By similarity); Belongs to the POMP/UMP1 family.


ensembl_gene_id: O74421
symbol: coq3
gene_biotype: protein_coding
description:
  Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.


ensembl_gene_id: O74423
symbol: ent1
gene_biotype: protein_coding
description:
  Epsin-1; Binds to membranes enriched in phosphatidylinositol 3,5- bisphosphate (PtdIns(3,5)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Required for endocytosis and localization of actin. Belongs to the epsin family.


ensembl_gene_id: O74424
symbol: nup211
gene_biotype: protein_coding
description:
  Nucleoporin nup211; Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope.


ensembl_gene_id: O74426
symbol: ppk33
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase ppk33; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.


ensembl_gene_id: O74427
symbol: urk1
gene_biotype: protein_coding
description:
  Uridine kinase; Catalyzes the conversion of uridine into UMP and cytidine into CMP in the pyrimidine salvage pathway.


ensembl_gene_id: O74428
symbol: tco89
gene_biotype: protein_coding
description:
  Target of rapamycin complex 1 subunit tco89; Component of TORC1, which regulates multiple cellular processes to control cell growth in response to environmental signals. Tor2 is essential for growth. Nutrient limitation and environmental stress signals cause inactivation of TORC1. Active TORC1 positively controls cell growth and ribosome biogenesis by regulating ribosomal protein gene expression. TORC1 negatively controls G1 cell-cycle arrest, sexual development and amino acid uptake. Represses mating, meiosis and sporulation efficiency by interfering with the functions of the transcri [...]


ensembl_gene_id: O74429
symbol: asp1
gene_biotype: protein_coding
description:
  Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis- diphosphoinositol tetrakisphosphate, (PP)2-InsP4. Phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP- InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2-InsP4 (B [...]


ensembl_gene_id: O74431
symbol: SPCC1672.11c
gene_biotype: protein_coding
description:
  Probable cation-transporting ATPase C1672.11c; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.


ensembl_gene_id: O74432
symbol: get4
gene_biotype: protein_coding
description:
  Golgi to ER traffic protein 4; May play a role in insertion of tail-anchored proteins into the endoplasmic reticulum membrane; Belongs to the GET4 family.


ensembl_gene_id: O74433
symbol: qcr9
gene_biotype: protein_coding
description:
  Cytochrome b-c1 complex subunit 9; Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inn [...]


ensembl_gene_id: O74435
symbol: cdc31
gene_biotype: protein_coding
description:
  Cell division control protein 31; Required for the proper coordination between exit from mitosis and the initiation of septation. Has a role in bipolar spindle formation during spindle pole body (SPB) duplication. Required for the localization of sad1 to the SPB.


ensembl_gene_id: O74436
symbol: srp68
gene_biotype: protein_coding
description:
  Signal recognition particle subunit srp68; Signal-recognition-particle (SRP) assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum (ER) membrane. SRP is required for the cotranslational protein translocation for ER import and preferentially recognizes strongly hydrophobic signal sequences. It is involved in targeting the nascent chain-ribosome (RNC) complex to the ER and is proposed to participate in the arrest of nascent chain elongation during membrane targeting. Srp68 binds the 7S RNA (By similarity).


ensembl_gene_id: O74440
symbol: rpn8
gene_biotype: protein_coding
description:
  26S proteasome regulatory subunit rpn8; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.


ensembl_gene_id: O74441
symbol: ctl1
gene_biotype: protein_coding
description:
  Choline transporter-like protein ctl1; Required for the normal organization of the preautophagosomal structure (PAS) and for the correct subcellular location of atg9. Belongs to the CTL (choline transporter-like) family.


ensembl_gene_id: O74443
symbol: laf2
gene_biotype: protein_coding
description:
  SWIRM domain-containing protein laf2; Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.


ensembl_gene_id: O74444
symbol: mug122
gene_biotype: protein_coding
description:
  Meiotically up-regulated gene 122 protein; Has a role in meiosis; Belongs to the sorting nexin family.


ensembl_gene_id: O74445
symbol: rpt4
gene_biotype: protein_coding
description:
  Probable 26S proteasome subunit rpt4; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).


ensembl_gene_id: O74446
symbol: sif2
gene_biotype: protein_coding
description:
  Sad1-interacting factor 2; Required for sporulation where it is believed to have a role in meiotic nuclear division.


ensembl_gene_id: O74448
symbol: pin1
gene_biotype: protein_coding
description:
  Peptidyl-prolyl cis-trans isomerase pin1; Has a role in the G1/S stage transition of mitosis where it is involved in the dephosphorylation of cdc25 and wee1.


ensembl_gene_id: O74450
symbol: pop23
gene_biotype: protein_coding
description:
  Ribonucleases P/MRP protein subunit pop3; Required for processing of 5.8S rRNA (short form) at site A3 and for 5'- and 3'-processing of pre-tRNA.


ensembl_gene_id: O74451
symbol: pus3
gene_biotype: protein_coding
description:
  Putative tRNA pseudouridine synthase C16C4.06c; Belongs to the tRNA pseudouridine synthase TruA family.


ensembl_gene_id: O74453
symbol: skb15
gene_biotype: protein_coding
description:
  Shk1 kinase-binding protein 15; Negatively regulates pak1/shk1 kinase activity leading to proper execution of cytoskeletal remodeling and cytokinetic functions.


ensembl_gene_id: O74454
symbol: sts5
gene_biotype: protein_coding
description:
  Protein sts5; Required for the maintenance of cell shape during interphase. Required for localization of cortical actin to the growing tips before mitosis.


ensembl_gene_id: O74457
symbol: naa20
gene_biotype: protein_coding
description:
  N-terminal acetyltransferase B complex catalytic subunit naa20; Catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn, Met-Gln or Met-Met.


ensembl_gene_id: O74458
symbol: sfc4
gene_biotype: protein_coding
description:
  Transcription factor tau subunit sfc4; TFIIIC mediates tRNA and 5S RNA gene activation by binding to intragenic promoter elements. Upstream of the transcription start site, TFIIIC assembles the initiation complex TFIIIB-TFIIIC-tDNA, which is sufficient for RNA polymerase III recruitment and function. Part of the tauA domain of TFIIIC that binds boxA DNA promoter sites of tRNA and similar genes. Sfc4 is the TFIIIB assembling subunit of TFIIIC.


ensembl_gene_id: O74462
symbol: taf6
gene_biotype: protein_coding
description:
  Transcription initiation factor TFIID subunit 6; TAFs are components of the transcription factor IID (TFIID) complex that are essential for mediating regulation of RNA polymerase transcription; Belongs to the TAF6 family.


ensembl_gene_id: O74465
symbol: hrr1
gene_biotype: protein_coding
description:
  Helicase required for RNAi-mediated heterochromatin assembly 1; Has a role in the RNA interference (RNAi) pathway which is important for heterochromatin formation and accurate chromosome segregation. A member of the RNA-directed RNA polymerase complex (RDRC) which is involved in the generation of small interfering RNAs (siRNAs) and mediate their association with the RNA-induced transcriptional silencing (RITS) complex. RITS acts as a priming complex for dsRNA synthesis at the site of non-coding centromeric RNA.


ensembl_gene_id: O74467
symbol: set5
gene_biotype: protein_coding
description:
  SET domain-containing protein 5; Belongs to the class V-like SAM-binding methyltransferase superfamily.


ensembl_gene_id: O74468
symbol: met1
gene_biotype: protein_coding
description:
  Probable uroporphyrinogen-III C-methyltransferase; Siroheme synthase involved in methionine biosynthesis. Belongs to the precorrin methyltransferase family.


ensembl_gene_id: O74469
symbol: cti1
gene_biotype: protein_coding
description:
  Exosome complex protein C1739.07; Required for exosome-dependent processing of pre-rRNA and small nucleolar RNA (snRNA) precursors. Involved in processing of 35S pre-rRNA at the A0, A1 and A2 sites (By similarity); Belongs to the C1D family.


ensembl_gene_id: O74471
symbol: cox13
gene_biotype: protein_coding
description:
  Cytochrome c oxidase subunit 13, mitochondrial; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane [...]


ensembl_gene_id: O74473
symbol: cdc11
gene_biotype: protein_coding
description:
  Septation initiation network scaffold protein cdc11; Essential for the onset of septum formation. Involved in the organization of astral microtubules during mitosis. Acts as a bridge between sid4 and the other SIN proteins mediating their association with the spindle pole body (SPB). The sid4-cdc11 complex organizes a signaling hub on the SPB which coordinates cell and nuclear division.


ensembl_gene_id: O74476
symbol: sal3
gene_biotype: protein_coding
description:
  Importin subunit beta-3; Involved in the nuclear import of cdc25 and mcs1. Belongs to the importin beta family. Importin beta-3 subfamily.


ensembl_gene_id: O74478
symbol: pgm2
gene_biotype: protein_coding
description:
  Probable phosphoribomutase; Converts ribose 1-phosphate to ribose 5-phosphate. Involved in ribose salvage via the pentose phosphate pathway. Belongs to the phosphohexose mutase family.


ensembl_gene_id: O74479
symbol: atp5
gene_biotype: protein_coding
description:
  ATP synthase subunit 5, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the centr [...]


ensembl_gene_id: O74483
symbol: lsm8
gene_biotype: protein_coding
description:
  U6 snRNA-associated Sm-like protein LSm8; Probable component of the spliceosome; Belongs to the snRNP Sm proteins family.


ensembl_gene_id: O74484
symbol: mpg1
gene_biotype: protein_coding
description:
  Mannose-1-phosphate guanyltransferase; Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell-size checkpoint. Required for the correct assembly of the septum. Belongs to the transferase hexapeptide repeat family.


ensembl_gene_id: O74489
symbol: zta1
gene_biotype: protein_coding
description:
  Probable quinone oxidoreductase; Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.


ensembl_gene_id: O74490
symbol: ist1
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein ist1; Involved in a late step in sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles. The lumenal sequestrated membrane proteins are targeted into the vacuole after fusion of the endosome with the vacuole (By similarity). Belongs to the IST1 family.


ensembl_gene_id: O74492
symbol: SPCC285.04
gene_biotype: protein_coding
description:
  Probable 5-hydroxyisourate hydrolase; Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo- 4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.


ensembl_gene_id: O74493
symbol: SPCC285.05
gene_biotype: protein_coding
description:
  Probable purine nucleoside permease C285.05; Probable nucleoside permease that transports adenosine and guanosine; Belongs to the NUP family.


ensembl_gene_id: O74496
symbol: ret2
gene_biotype: protein_coding
description:
  Coatomer subunit delta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity).


ensembl_gene_id: O74498
symbol: dsc5
gene_biotype: protein_coding
description:
  UBX domain-containing protein 10; Involved in protein degradation through the ubiquitin/proteasome pathway.


ensembl_gene_id: O74499
symbol: lsm7
gene_biotype: protein_coding
description:
  U6 snRNA-associated Sm-like protein LSm7; Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner. Probable component of the spliceosome; Belongs to the snRNP Sm proteins family.


ensembl_gene_id: O74500
symbol: nup60
gene_biotype: protein_coding
description:
  Nucleoporin nup60; Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (By similarity).


ensembl_gene_id: O74502
symbol: msh6
gene_biotype: protein_coding
description:
  DNA mismatch repair protein msh6; Involved in post-replicative DNA-mismatch repair. Has a role towards base-base mispairs and insertion-deletion loops.


ensembl_gene_id: O74503
symbol: spp27
gene_biotype: protein_coding
description:
  Upstream activation factor subunit spp27; Component of the UAF (upstream activation factor) complex which interacts with the upstream element of the RNA polymerase I promoter and forms a stable preinitiation complex. UAF seems to stimulate basal transcription to a fully activated level.


ensembl_gene_id: O74509
symbol: vsl1
gene_biotype: protein_coding
description:
  Vacuolar morphogenesis protein 7 homolog; Essential for proper morphogenesis of the vacuole. May exist as structural reinforcement on the surface of the vacuolar membrane and be required for maintenance against rupture by osmotic pressure (By similarity).


ensembl_gene_id: O74510
symbol: bqt3
gene_biotype: protein_coding
description:
  Bouquet formation protein 3; Connects telomeres to the nuclear envelop (NE) during both vegetative growth and meiosis. This connection ensures clustering of telomeres to the spindle pole body (SPB) when cells enter meiotic prophase.


ensembl_gene_id: O74511
symbol: ekc1
gene_biotype: protein_coding
description:
  Extragenic suppressor of kinetochore protein 1; Has a role in chromosome segregation. May provide a dynamic connection between kinetochore microtubules and kinetochore chromatin. Belongs to the SAPS family.


ensembl_gene_id: O74515
symbol: cia1
gene_biotype: protein_coding
description:
  Histone chaperone cia1; Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly.


ensembl_gene_id: O74516
symbol: trm44
gene_biotype: protein_coding
description:
  tRNA (uracil-O(2)-)-methyltransferase; Probable adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.


ensembl_gene_id: O74518
symbol: cid12
gene_biotype: protein_coding
description:
  Poly(A) RNA polymerase cid12; Has a role in the RNA interference (RNAi) pathway which is important for heterochromatin formation and accurate chromosome segregation. A member of the RNA-directed RNA polymerase complex (RDRC) which is involved in the generation of small interfering RNAs (siRNAs) and mediate their association with the RNA-induced transcriptional silencing (RITS) complex. RITS acts as a priming complex for dsRNA synthesis at the site of non-coding centromeric RNA.


ensembl_gene_id: O74522
symbol: adn3
gene_biotype: protein_coding
description:
  Adhesion defective protein 3; Probable transcriptional regulator involved in cell adhesion. Belongs to the FLO8 family.


ensembl_gene_id: O74523
symbol: inh1
gene_biotype: protein_coding
description:
  Putative ATPase inhibitor, mitochondrial; Forms a one-to-one complex with ATPase to inhibit the enzyme activity completely.


ensembl_gene_id: O74524
symbol: put1
gene_biotype: protein_coding
description:
  Probable proline dehydrogenase, mitochondrial; Converts proline to delta-1-pyrroline-5-carboxylate. Belongs to the proline oxidase family.


ensembl_gene_id: O74529
symbol: SPCC70.08c
gene_biotype: protein_coding
description:
  Uncharacterized methyltransferase C70.08c; Probable methyltransferase; Belongs to the methyltransferase superfamily.


ensembl_gene_id: O74533
symbol: qcr7
gene_biotype: protein_coding
description:
  Cytochrome b-c1 complex subunit 7; Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inn [...]


ensembl_gene_id: O74535
symbol: ppn1
gene_biotype: protein_coding
description:
  Cleavage and polyadenylation factor complex subunit C74.02c; RNA-binding component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation- dependent pre-mRNA 3'-end formation. Involved in poly(A) site recognition. May be involved in coupling transcription termination and mRNA 3'-end formation.


ensembl_gene_id: O74536
symbol: ssp2
gene_biotype: protein_coding
description:
  SNF1-like protein kinase ssp2; Serine/threonine protein kinase essential for release from glucose repression via the phosphorylation of scr1 upon glucose deprivation. Catalytic subunit of the AMP-activated protein kinase complex also known as the SNF1 kinase complex (Snf1c), a central regulator of cellular energy homeostasis, which, in response to a fall in intracellular ATP levels, activates energy-producing pathways and inhibits energy-consuming processes. The complex phosphorylates histone H3 to form H3S10ph, which promotes H3K14ac formation, leading to transcriptional activation th [...]


ensembl_gene_id: O74539
symbol: mak3
gene_biotype: protein_coding
description:
  Peroxide stress-activated histidine kinase mak3; Involved in the control of the SAPK-dependent transcriptional response to peroxide stress. Regulates sty1 activity.


ensembl_gene_id: O74542
symbol: SPCC777.03c
gene_biotype: protein_coding
description:
  Uncharacterized aminotransferase C777.03c; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.


ensembl_gene_id: O74544
symbol: gtr2
gene_biotype: protein_coding
description:
  GTP-binding protein gtr2; GTPase. Component of the GSE complex, a GTPase complex required for intracellular sorting of GAP1 out of the endosome (By similarity).


ensembl_gene_id: O74546
symbol: omh3
gene_biotype: protein_coding
description:
  O-glycoside alpha-1,2-mannosyltransferase homolog 3; Probable mannosyltransferase involved in O-glycosylation of cell wall and secreted proteins; Belongs to the glycosyltransferase 15 family.


ensembl_gene_id: O74547
symbol: bit61
gene_biotype: protein_coding
description:
  Target of rapamycin complex 2 subunit bit61; Component of TORC2, which regulates multiple cellular processes to control cell growth in response to environmental signals. TORC2 is required for cell survival under various stress conditions. TORC2 positively controls G1 cell-cycle arrest, sexual development and amino acid uptake. Positively regulates amino acid uptake through the control of expression of amino acid permeases. Belongs to the BIT61 family.


ensembl_gene_id: O74548
symbol: arg1
gene_biotype: protein_coding
description:
  Probable acetylornithine aminotransferase, mitochondrial; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.


ensembl_gene_id: O74549
symbol: ubc12
gene_biotype: protein_coding
description:
  NEDD8-conjugating enzyme ubc12; Accepts the ubiquitin-like protein NEDD8/RUB1 from the UBA3- ULA1 E1 complex and catalyzes its covalent attachment to other proteins; Belongs to the ubiquitin-conjugating enzyme family. UBC12 subfamily.


ensembl_gene_id: O74552
symbol: vps35
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. Required for the endosome-to-Golgi retrieval of the vacuolar protein sorting receptor vps10. Required to form proper forespore membranes. Belongs to the VPS35 family.


ensembl_gene_id: O74553
symbol: dus4
gene_biotype: protein_coding
description:
  tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]; Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.


ensembl_gene_id: O74555
symbol: bpb1
gene_biotype: protein_coding
description:
  Branchpoint-bridging protein; Necessary for the splicing of pre-mRNA. The BPB1(SF1)-u2af59- u2af23 complex has a role in the recognition of the branch site (5'- UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.


ensembl_gene_id: O74557
symbol: cbr1
gene_biotype: protein_coding
description:
  NADH-cytochrome b5 reductase 1; Electron donor reductase for cytochrome b5. The cytochrome b5/NADH cytochrome b5 reductase electron transfer system supports the catalytic activity of several sterol biosynthetic enzymes (By similarity).


ensembl_gene_id: O74558
symbol: mob2
gene_biotype: protein_coding
description:
  Maintenance of ploidy protein mob2; Required for coordinating polarized cell growth during interphase with the onset of mitosis; Belongs to the MOB1/phocein family.


ensembl_gene_id: O74560
symbol: raf2
gene_biotype: protein_coding
description:
  Rik1-associated factor 2; Component of the rik1-associated E3 ubiquitin ligase complex that shows ubiquitin ligase activity and is required for histone H3K9 methylation. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting swi6/HP1 to methylated histones which leads to transcriptional silencing within centromeric heterochromatin, telomeric regions and at the silent mating-type loci. Has a role in both mitotic and meiotic chromosome segregation.


ensembl_gene_id: O74562
symbol: sec8
gene_biotype: protein_coding
description:
  Exocyst complex component sec8; Component of the exocyst complex involved in the delivery of secretory vesicles to the plasma membrane. Also required for polarized cell growth and division septum assembly. The exocyst complex plays an important role in the targeting of rho3, as well as the two main hydrolases required for cell separation, eng1 and agn1, to the cell wall surrounding the septum before cell separation begins.


ensembl_gene_id: O74563
symbol: brl2
gene_biotype: protein_coding
description:
  E3 ubiquitin-protein ligase brl2; E3 ubiquitin-protein ligase which belongs to the histone H2B ubiquitin ligase complex (HULC) which mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation.


ensembl_gene_id: O74627
symbol: pch1
gene_biotype: protein_coding
description:
  Cyclin pch1; Essential for progression through the whole cell cycle. Belongs to the cyclin family. Cyclin C subfamily.


ensembl_gene_id: O74630
symbol: tel1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Undirectly involved in the phosphorylation of rad32 which is necessary for its telomere function. Required for the control of telomere length [...]


ensembl_gene_id: O74635
symbol: rpb9
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerase II subunit RPB9; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB9 is part of the upper jaw surrounding the central large cleft and thought to grab the incoming DNA template (By similarity). Involved in the regulation o [...]


ensembl_gene_id: O74690
symbol: snu13
gene_biotype: protein_coding
description:
  13 kDa ribonucleoprotein-associated protein; Common component of the spliceosome and rRNA processing machinery. In association with the spliceosomal U4/U6.U5 tri-snRNP particle, required for splicing of pre-mRNA. In association with box C/D snoRNPs, required for processing of pre-ribosomal RNA (rRNA) and site-specific 2'-O-methylation of substrate RNAs. Essential for the accumulation and stability of U4 snRNA, U6 snRNA, and box C/D snoRNAs (By similarity).


ensembl_gene_id: O74718
symbol: sup35
gene_biotype: protein_coding
description:
  Eukaryotic peptide chain release factor GTP-binding subunit; Involved in translation termination. Stimulates the activity of ERF1. Binds guanine nucleotides; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. ERF3 subfamily.


ensembl_gene_id: O74729
symbol: cyp3
gene_biotype: protein_coding
description:
  Peptidyl-prolyl cis-trans isomerase cyp3; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).


ensembl_gene_id: O74731
symbol: dus2
gene_biotype: protein_coding
description:
  tRNA-dihydrouridine(20) synthase [NAD(P)+]; Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.


ensembl_gene_id: O74733
symbol: cft1
gene_biotype: protein_coding
description:
  Protein cft1; RNA-binding component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation- dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. Involved in poly(A) site recognition. May be involved in coupling transcription termination and mRNA 3'-end formation (By similarity); Belongs to the CFT1 family.


ensembl_gene_id: O74734
symbol: rrf1
gene_biotype: protein_coding
description:
  Putative ribosomal recycling factor, mitochondrial; Necessary for protein synthesis in mitochondria. Functions as a ribosome recycling factor in mitochondria; Belongs to the RRF family.


ensembl_gene_id: O74735
symbol: atx1
gene_biotype: protein_coding
description:
  Metal homeostasis factor atx1; Shuttles copper to the transport ATPase ccc2. Protects against oxygen toxicity (By similarity); Belongs to the ATX1 family.


ensembl_gene_id: O74736
symbol: png2
gene_biotype: protein_coding
description:
  Chromatin modification-related protein png2; Component of the clr6 histone deacetylase complex I' responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Has a role in silencing of mating type genes.


ensembl_gene_id: O74738
symbol: set10
gene_biotype: protein_coding
description:
  Ribosomal lysine N-methyltransferase set10; S-adenosyl-L-methionine-dependent protein-lysine N- methyltransferase that methylates ribosomal protein L23 (rpl23a and rpl23b); Belongs to the class V-like SAM-binding methyltransferase superfamily. RKM1 family.


ensembl_gene_id: O74739
symbol: ngl1
gene_biotype: protein_coding
description:
  Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase; Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins [...]


ensembl_gene_id: O74740
symbol: cft2
gene_biotype: protein_coding
description:
  Cleavage factor two protein 2; RNA-binding component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation- dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. May be involved in poly(A)-site recognition. May be involved in the association of the CPF, CPFIA and RNA polymerase II complexes (By similarity).


ensembl_gene_id: O74741
symbol: SPBC1709.16c
gene_biotype: protein_coding
description:
  4,5-DOPA dioxygenase extradiol-like protein; May be involved in the metabolism of aromatic compounds.


ensembl_gene_id: O74742
symbol: met7
gene_biotype: protein_coding
description:
  Probable folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.


ensembl_gene_id: O74743
symbol: tif452
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 4E-2; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures; Belongs to the eukaryotic initiation factor 4E family.


ensembl_gene_id: O74745
symbol: anp1
gene_biotype: protein_coding
description:
  Mannan polymerase II complex anp1 subunit; The M-Pol II complex possesses alpha-1,6-mannosyltransferase activity and is probably involved in the elongation of the mannan backbone of N-linked glycans on cell wall and periplasmic proteins.


ensembl_gene_id: O74747
symbol: rhp18
gene_biotype: protein_coding
description:
  Postreplication repair E3 ubiquitin-protein ligase rad18; E3 RING-finger protein, member of the UBC2/RAD6 epistasis group. Associates to the E2 ubiquitin conjugating enzyme ubc2/rad6 to form the ubc2-rad18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA (By similarity).


ensembl_gene_id: O74748
symbol: trs8502
gene_biotype: protein_coding
description:
  Transport protein particle subunit trs85-2; Component of the TRAPP I and TRAPP II complexes. TRAPP I plays a key role in the late stages of endoplasmic reticulum to Golgi traffic. TRAPP II seems to play a role in intra-Golgi transport. Has a role late in meiosis following DNA replication (By similarity).


ensembl_gene_id: O74749
symbol: hse1
gene_biotype: protein_coding
description:
  Class E vacuolar protein-sorting machinery protein hse1; Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB).


ensembl_gene_id: O74750
symbol: yea4
gene_biotype: protein_coding
description:
  UDP-N-acetylglucosamine transporter yea4; Sugar transporter that specifically mediates the transport of UDP-N-acetylglucosamine (UDP-GlcNAc) and is required for cell wall chitin synthesis; Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.


ensembl_gene_id: O74752
symbol: mas5
gene_biotype: protein_coding
description:
  Mitochondrial protein import protein mas5; Probably involved in mitochondrial protein import (By similarity). Plays a role in microtubule cytoskeleton organization.


ensembl_gene_id: O74754
symbol: atp3
gene_biotype: protein_coding
description:
  ATP synthase subunit gamma, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the  [...]


ensembl_gene_id: O74756
symbol: chs2
gene_biotype: protein_coding
description:
  Chitin synthase-like protein 2; Plays a role in septum formation. Has no chitin synthase activity; Belongs to the chitin synthase family.


ensembl_gene_id: O74757
symbol: hrd1
gene_biotype: protein_coding
description:
  ERAD-associated E3 ubiquitin-protein ligase hrd1; E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated E2 ligases, and transfers it to substrates promoting their degradation. Mediates the degradation of endoplasmic reticulum proteins (ERQC), also called ER- associated degradation (ERAD). Component of the hrd1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER-membrane proteins with misfolde [...]


ensembl_gene_id: O74759
symbol: nto1
gene_biotype: protein_coding
description:
  Mst2 complex subunit nto1; Component of the mst2 complex which is a highly specific H3 lysine 14 (H3K14) acetyltransferase that functions together with gcn5 to regulate global levels of H3K14 acetylation (H3K14ac), critical for DNA damage checkpoint activation.


ensembl_gene_id: O74760
symbol: tif301
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 3 subunit A; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.


ensembl_gene_id: O74761
symbol: spp2
gene_biotype: protein_coding
description:
  DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.


ensembl_gene_id: O74762
symbol: rpn2
gene_biotype: protein_coding
description:
  26S proteasome regulatory subunit rpn2; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.


ensembl_gene_id: O74764
symbol: spb4
gene_biotype: protein_coding
description:
  ATP-dependent rRNA helicase spb4; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.


ensembl_gene_id: O74765
symbol: SPBC24C6.03
gene_biotype: protein_coding
description:
  Probable proline--tRNA ligase, mitochondrial; Belongs to the class-II aminoacyl-tRNA synthetase family.


ensembl_gene_id: O74766
symbol: put2
gene_biotype: protein_coding
description:
  Probable delta-1-pyrroline-5-carboxylate dehydrogenase; Belongs to the aldehyde dehydrogenase family.


ensembl_gene_id: O74767
symbol: sec28
gene_biotype: protein_coding
description:
  Probable coatomer subunit epsilon; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity).


ensembl_gene_id: O74771
symbol: dip1
gene_biotype: protein_coding
description:
  Protein dip1; May be involved in protein-linked oligosaccharide phosphorylation; Belongs to the LDB17 family.


ensembl_gene_id: O74772
symbol: cwf14
gene_biotype: protein_coding
description:
  Pre-mRNA-splicing factor cwf14; Involved in mRNA splicing where it associates with cdc5 and the other cwf proteins as part of the spliceosome.


ensembl_gene_id: O74773
symbol: msh2
gene_biotype: protein_coding
description:
  DNA mismatch repair protein msh2; Involved in post-replicative DNA-mismatch repair. Binds to mismatch-containing DNA. Required for correct termination of copy synthesis during mating-type switching. Also required for proper chromosome organization during meiosis.


ensembl_gene_id: O74774
symbol: hbs1
gene_biotype: protein_coding
description:
  Elongation factor 1 alpha-like protein; Involved in protein translation. Together with dom34, may function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs (By similarity).


ensembl_gene_id: O74776
symbol: mtg1
gene_biotype: protein_coding
description:
  Mitochondrial GTPase 1; Mitochondrial GTPase involved in assembly of the large ribosomal subunit (By similarity). Plays a role in expression of the mitochondrial translational machinery (By similarity). Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.


ensembl_gene_id: O74777
symbol: mis3
gene_biotype: protein_coding
description:
  KRR1 small subunit processome component homolog; Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.


ensembl_gene_id: O74778
symbol: btb2
gene_biotype: protein_coding
description:
  BTB/POZ domain-containing protein 2; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.


ensembl_gene_id: O74779
symbol: mmb1
gene_biotype: protein_coding
description:
  Microtubule-associated protein mug164; Involved in the cell polarity process and in regulation of microtubule growth. Has a role in meiosis.


ensembl_gene_id: O74781
symbol: mrs1
gene_biotype: protein_coding
description:
  Probable arginine--tRNA ligase, cytoplasmic; Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis.


ensembl_gene_id: O74783
symbol: pof2
gene_biotype: protein_coding
description:
  SCF E3 ubiquitin ligase complex F-box protein pof2; Involved in substrate recognition in ubiquitin-dependent degradation.


ensembl_gene_id: O74786
symbol: sec9
gene_biotype: protein_coding
description:
  Protein transport protein sec9; Has a role in cell separation, a final step of cytokinesis and in the assembly of the forespore membrane. May have a role in the transport of secretory proteins to these growing sites.


ensembl_gene_id: O74787
symbol: cho2
gene_biotype: protein_coding
description:
  Phosphatidylethanolamine N-methyltransferase; Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME); Belongs to the class VI-like SAM-binding methyltransferase superfamily. CHO2 family.


ensembl_gene_id: O74789
symbol: pph3
gene_biotype: protein_coding
description:
  Putative serine/threonine-protein phosphatase C26H8.05c; Belongs to the PPP phosphatase family. PP-1 subfamily.


ensembl_gene_id: O74790
symbol: grx4
gene_biotype: protein_coding
description:
  Monothiol glutaredoxin-4; Monothiol glutaredoxin involved in the biogenesis of iron- sulfur clusters (By similarity). Binds one iron-sulfur cluster per dimer. The iron-sulfur cluster is bound between subunits, and is complexed by a bound glutathione and a cysteine residue from each subunit (By similarity).


ensembl_gene_id: O74791
symbol: grn1
gene_biotype: protein_coding
description:
  GTPase grn1; Required for optimal growth. Required for normal processing of ribosomal pre-rRNA. Required for nuclear export of ribosomal protein rpl2501; Belongs to the TRAFAC class YlqF/YawG GTPase family.


ensembl_gene_id: O74792
symbol: snf59
gene_biotype: protein_coding
description:
  SWI/SNF global transcription activator complex subunit snf59; Component of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, which is required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors.


ensembl_gene_id: O74794
symbol: cyc3
gene_biotype: protein_coding
description:
  Putative cytochrome c heme lyase; Links covalently the heme group to the apoprotein of cytochrome c.


ensembl_gene_id: O74796
symbol: orc6
gene_biotype: protein_coding
description:
  Origin recognition complex subunit 6; Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. ORC binds to multiple sites within the ars1 origin of DNA replication in an ATP-independent manner.


ensembl_gene_id: O74798
symbol: aly2
gene_biotype: protein_coding
description:
  Putative arrestin-related trafficking adapter C2D10.04; May regulate endocytosis in response to extracellular stimuli; Belongs to the ALY1 family.


ensembl_gene_id: O74800
symbol: mmp1
gene_biotype: protein_coding
description:
  Mitochondrial inner membrane protease subunit 1; Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space.


ensembl_gene_id: O74802
symbol: snr1
gene_biotype: protein_coding
description:
  3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has an indirect role in endocytic membrane trafficking. May have a function in protein biosynthesis in mitochondrial small ribosomal subunit (By similarity).


ensembl_gene_id: O74803
symbol: rhp23
gene_biotype: protein_coding
description:
  UV excision repair protein rhp23; Involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA.


ensembl_gene_id: O74804
symbol: est1
gene_biotype: protein_coding
description:
  Telomere elongation protein est1; Directly involved in telomere replication. Associates with telomerase and during its interaction with trt1, telomerase activity is promoted; Belongs to the EST1 family.


ensembl_gene_id: O74805
symbol: myo51
gene_biotype: protein_coding
description:
  Myosin-51; Involved in cytokinesis; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.


ensembl_gene_id: O74807
symbol: mhf1
gene_biotype: protein_coding
description:
  Inner kinetochore subunit mhf1; dsDNA-binding component of a FANCM-MHF complex involved in DNA damage repair and genome maintenance. FANCM-MHF promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork (Probable). FANCM-MHF promotes non-crossover recombination both in mitotic and meiotic cells. Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinet [...]


ensembl_gene_id: O74808
symbol: clr1
gene_biotype: protein_coding
description:
  Cryptic loci regulator protein 1; Regulates silencing of the mat2 and mat3 loci. Organizes the chromatin structure of the mating-type region where it also participates in establishing the 'cold spot' for recombination. Required for proper positioning of nucleosomes at heterochromatic loci and for transcriptional gene silencing (TGS) function of the Snf2/Hdac- containing repressor complex (SHREC).


ensembl_gene_id: O74810
symbol: ubc1
gene_biotype: protein_coding
description:
  Ubiquitin-conjugating enzyme E2 1; Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in degradation of misfolded or regulated proteins localized in the endoplasmic reticulum (ER) lumen or membrane via the ubiquitin-proteasome system. Cognate E2 conjugating enzyme for the HRD1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER- membrane proteins with misfolded transmembrane domains (ERAD-M).


ensembl_gene_id: O74820
symbol: erg28
gene_biotype: protein_coding
description:
  Ergosterol biosynthetic protein 28; May have a role in anchoring erg26 and erg27 to the endoplasmic reticulum. May also be responsible for facilitating their interaction (By similarity); Belongs to the ERG28 family.


ensembl_gene_id: O74821
symbol: dre2
gene_biotype: protein_coding
description:
  Fe-S cluster assembly protein dre2; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex cfd1-nbp35. Electrons are transferred to dre2 from NADPH via the FAD- and FMN-containing protein tah18. Tah18-dre2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by  [...]


ensembl_gene_id: O74824
symbol: gtr1
gene_biotype: protein_coding
description:
  GTP-binding protein gtr1; GTPase. Component of the GSE complex, a GTPase complex required for intracellular sorting of GAP1 out of the endosome (By similarity).


ensembl_gene_id: O74825
symbol: rpb4
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerase II subunit rpb4; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB4 is part of a subcomplex with RPB7 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems  [...]


ensembl_gene_id: O74826
symbol: coq7
gene_biotype: protein_coding
description:
  5-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides.


ensembl_gene_id: O74827
symbol: cho1
gene_biotype: protein_coding
description:
  Phosphatidyl-N-methylethanolamine N-methyltransferase; Catalyzes the second two steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylmonomethylethanolamine (PMME) to phosphatidyldimethylethanolamine (PDME) and of PDME to phosphatidylcholine (PC).


ensembl_gene_id: O74828
symbol: esf1
gene_biotype: protein_coding
description:
  Pre-rRNA-processing protein esf1; Involved in the 18S rRNA synthesis. Required for the early cleavages at sites A0, A1 and A2 (By similarity); Belongs to the ESF1 family.


ensembl_gene_id: O74830
symbol: SPCC1183.02
gene_biotype: protein_coding
description:
  Putative glutathione S-transferase C1183.02; Involved in the oxidative stress response and detoxification.


ensembl_gene_id: O74831
symbol: fxn1
gene_biotype: protein_coding
description:
  Frataxin homolog, mitochondrial; Promotes the biosynthesis of heme as well as the assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+). May be able to store large amounts of the metal in the form of a ferrihydrite mineral by oligomerization (By similarity); Belongs to the frataxin family.


ensembl_gene_id: O74832
symbol: pet127
gene_biotype: protein_coding
description:
  mRNA degradation protein pet127, mitochondrial; Required for the degradation of mRNA in mitochondria. Belongs to the PET127 family.


ensembl_gene_id: O74834
symbol: ung1
gene_biotype: protein_coding
description:
  Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.


ensembl_gene_id: O74835
symbol: rrp5
gene_biotype: protein_coding
description:
  rRNA biogenesis protein rrp5; Involved in the biogenesis of rRNA. Required for the formation of 18S and 5.8S rRNA (By similarity).


ensembl_gene_id: O74839
symbol: msy1
gene_biotype: protein_coding
description:
  Mechanosensitive ion channel protein Msy1; Regulates intracellular calcium levels and cell volume for survival in response to hypo-osmotic shock. Acts as a mechanosensitive calcium channel in response to membrane stretch. The conductance is about 0.25 nanosiemens. Involved in maintaining vacuole integrity and protecting the nuclear envelope upon hypo-osmotic shock.


ensembl_gene_id: O74842
symbol: fft2
gene_biotype: protein_coding
description:
  ATP-dependent helicase fft2; DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for heterochromatin organization.


ensembl_gene_id: O74844
symbol: fta7
gene_biotype: protein_coding
description:
  Inner kinetochore subunit fta7; Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore COMA complex, which connects centromere-associated proteins and the outer kinetochore. COMA interacts with other inner kinetochore proteins to form the inner kinetochore constitutive centromere- associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.


ensembl_gene_id: O74845
symbol: hif2
gene_biotype: protein_coding
description:
  Set3 complex subunit hif2; Component of the set3 histone deacetylase complex which is involved in chromatin remodeling and transcription regulation, such as repression of the sporulation gene program.


ensembl_gene_id: O74846
symbol: sec6
gene_biotype: protein_coding
description:
  Exocyst complex component sec6; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.


ensembl_gene_id: O74849
symbol: ght6
gene_biotype: protein_coding
description:
  High-affinity fructose transporter ght6; High-affinity fructose transporter; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.


ensembl_gene_id: O74850
symbol: dga1
gene_biotype: protein_coding
description:
  Diacylglycerol O-acyltransferase 1; Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Cells defective in triacylglycerol synthesis undergo apoptosis upon entry into the stationary phase. Generation of reactive oxygen species (ROS) is essential to lipoapoptosis. Also has monoacylglycerol acyltransferase (MGAT) activity, catalyzing the acyl- CoA-dependent esterification of monoacylglycerol to diacylglycerol (By similarity).


ensembl_gene_id: O74851
symbol: adg3
gene_biotype: protein_coding
description:
  Probable secreted beta-glucosidase adg3; Cell surface beta-glucosidase involved in cell wall biogenesis,; Belongs to the SUN family.


ensembl_gene_id: O74853
symbol: SPCC18.03
gene_biotype: protein_coding
description:
  FKBP12-associated protein 1 homolog; May play a role in transcription regulation; Belongs to the NFX1 family.


ensembl_gene_id: O74855
symbol: rsa4
gene_biotype: protein_coding
description:
  Ribosome assembly protein 4; Involved in ribosome biogenesis. Required for processing and efficient intra-nuclear transport of pre-60S ribosomal subunits. Interacts with the AAA-ATPase Midasin, which is essential for the ATP- dependent dissociation of a group of nonribosomal factors from the pre- 60S particle.


ensembl_gene_id: O74856
symbol: caf1
gene_biotype: protein_coding
description:
  Poly(A) ribonuclease pop2; Acts as the catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. In vivo and in vitro, caf1 has 3'-exoribonuclease activity with a preference for poly(A) RNAs.


ensembl_gene_id: O74857
symbol: rpc53
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerase III subunit rpc4; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Essential for tRNA synthesis. The RPC53/RPC4-RPC37/RPC5 subcomplex is required for terminator recognition and reinitiation (By similarity).


ensembl_gene_id: O74859
symbol: hnt3
gene_biotype: protein_coding
description:
  Aprataxin-like protein; DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'- phosphate termini that can be efficiently rejoined. Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, bu [...]


ensembl_gene_id: O74860
symbol: SPCC18.10
gene_biotype: protein_coding
description:
  Putative pyridoxal kinase C18.10; Required for synthesis of pyridoxal-5-phosphate from vitamin B6; Belongs to the pyridoxine kinase family.


ensembl_gene_id: O74861
symbol: sdc1
gene_biotype: protein_coding
description:
  Set1 complex component sdc1; The COMPASS (Set1C) complex specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently activates gene expression by regulating transcription elongation and plays a role in telomere length maintenance.


ensembl_gene_id: O74862
symbol: utp23
gene_biotype: protein_coding
description:
  rRNA-processing protein utp23; Involved in rRNA-processing and ribosome biogenesis. Belongs to the UTP23/FCF1 family. UTP23 subfamily.


ensembl_gene_id: O74863
symbol: trm82
gene_biotype: protein_coding
description:
  tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit trm82; Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit. Belongs to the WD repeat TRM82 family.


ensembl_gene_id: O74864
symbol: rpp0
gene_biotype: protein_coding
description:
  60S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10.


ensembl_gene_id: O74865
symbol: dph7
gene_biotype: protein_coding
description:
  Diphthine methyltransferase; Catalyzes the demethylation of diphthine methyl ester to form diphthine, an intermediate in diphthamide biosynthesis, a post- translational modification of histidine which occurs in translation elongation factor 2 (eft201 and eft202). Belongs to the DPH7 family.


ensembl_gene_id: O74866
symbol: fmn1
gene_biotype: protein_coding
description:
  Riboflavin kinase; Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) coenzyme.


ensembl_gene_id: O74869
symbol: nic1
gene_biotype: protein_coding
description:
  High-affinity nickel transport protein nic1; High-affinity nickel transporter responsible for nickel uptake. Required for urease biosynthesis. Belongs to the NiCoT transporter (TC 2.A.52) family.


ensembl_gene_id: O74870
symbol: mug73
gene_biotype: protein_coding
description:
  Meiotically up-regulated gene 73 protein; Has a role in meiosis; Belongs to the archaeal/bacterial/fungal opsin family.


ensembl_gene_id: O74873
symbol: sec231
gene_biotype: protein_coding
description:
  Protein transport protein sec23-1; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity).


ensembl_gene_id: O74874
symbol: ccr4
gene_biotype: protein_coding
description:
  Glucose-repressible alcohol dehydrogenase transcriptional effector; Acts as catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. Ccr4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single-stranded DNA. Discovered because of its role in the control of ADH2 gene expression. It is required for the expression of genes involved in non-fermentative growth (By similarity); Belongs to  [...]


ensembl_gene_id: O74878
symbol: alg11
gene_biotype: protein_coding
description:
  GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase; Required for N-linked oligosaccharide assembly. Has a role in the last step of the synthesis of the Man(5)GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum. Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.


ensembl_gene_id: O74879
symbol: enp2
gene_biotype: protein_coding
description:
  Ribosome biogenesis protein enp2 homolog; May be involved in rRNA-processing and ribosome biosynthesis.


ensembl_gene_id: O74880
symbol: pcm1
gene_biotype: protein_coding
description:
  mRNA cap guanine-N7 methyltransferase; Responsible for methylating the 5'-cap structure of mRNAs. Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.


ensembl_gene_id: O74881
symbol: btb1
gene_biotype: protein_coding
description:
  BTB/POZ domain-containing protein 1; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.


ensembl_gene_id: O74882
symbol: sdh3
gene_biotype: protein_coding
description:
  Succinate dehydrogenase cytochrome B subunit, mitochondrial; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).


ensembl_gene_id: O74883
symbol: rpc37
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerase III subunit rpc5; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. The RPC53/RPC4-RPC37/RPC5 subcomplex is required for terminator recognition and reinitiation (By similarity).


ensembl_gene_id: O74885
symbol: xan1
gene_biotype: protein_coding
description:
  Alpha-ketoglutarate-dependent xanthine dioxygenase xan1; Alpha-ketoglutarate-dependent xanthine dioxygenase is a non- heme mononuclear Fe(2+) enzyme that decarboxylates alpha-ketoglutarate to succinate and CO(2) while hydroxylating xanthine to generate uric acid. Allows xanthine utilization as a nitrogen source.


ensembl_gene_id: O74887
symbol: tpx1
gene_biotype: protein_coding
description:
  Peroxiredoxin tpx1; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Relays hydrogen peroxide as a signal to the transcription factor pap1 by inducing the formation of intramolecular disulfide bonds in pap1, which causes its nuclear accumulation and activation. Reduced by srx1 and this regulation acts as a molecular switch controlling the transcriptional  [...]


ensembl_gene_id: O74888
symbol: bxi1
gene_biotype: protein_coding
description:
  Bax inhibitor 1; Links the unfolded protein response and programmed cell death and mediates mitochondrial-dependent apoptosis. Induces cell death and disruption of the mitochondrial transmembrane potential (By similarity); Belongs to the BI1 family. LFG subfamily.


ensembl_gene_id: O74890
symbol: SPCC576.06c
gene_biotype: protein_coding
description:
  Tyrosine--tRNA ligase, mitochondrial; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr). Belongs to the class-I aminoacyl-tRNA synthetase family.


ensembl_gene_id: O74891
symbol: ret3
gene_biotype: protein_coding
description:
  Probable coatomer subunit zeta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity). The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its associatio [...]


ensembl_gene_id: O74894
symbol: rpt3
gene_biotype: protein_coding
description:
  26S proteasome regulatory subunit 6B homolog; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).


ensembl_gene_id: O74896
symbol: mhf2
gene_biotype: protein_coding
description:
  Inner kinetochore subunit mhf2; dsDNA-binding component of a FANCM-MHF complex involved in DNA damage repair and genome maintenance. FANCM-MHF promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork (Probable). FANCM-MHF promotes non-crossover recombination both in mitotic and meiotic cells. Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinet [...]


ensembl_gene_id: O74897
symbol: swc5
gene_biotype: protein_coding
description:
  SWR1-complex protein 5; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability (By similarity).


ensembl_gene_id: O74898
symbol: dph5
gene_biotype: protein_coding
description:
  Diphthine methyl ester synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.


ensembl_gene_id: O74906
symbol: bcd1
gene_biotype: protein_coding
description:
  Putative box C/D snoRNA protein SPCC613.07; Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis. Belongs to the BCD1 family.


ensembl_gene_id: O74907
symbol: SPCC613.08
gene_biotype: protein_coding
description:
  Protein bcp1; Involved in nuclear export, actin cytoskeleton organization and vesicular transport; Belongs to the BCP1 family.


ensembl_gene_id: O74908
symbol: sen54
gene_biotype: protein_coding
description:
  Probable tRNA-splicing endonuclease subunit sen54; Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of th [...]


ensembl_gene_id: O74910
symbol: raf1
gene_biotype: protein_coding
description:
  Rik1-associated factor 1; Component of the rik1-associated E3 ubiquitin ligase complex that shows ubiquitin ligase activity and is required for histone H3K9 methylation. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting swi6/HP1 to methylated histones which leads to transcriptional silencing within centromeric heterochromatin, telomeric regions and at the silent mating-type loci. Has a role in both mitotic and meiotic chromosome segregation.


ensembl_gene_id: O74914
symbol: hsp3101
gene_biotype: protein_coding
description:
  Glutathione-independent glyoxalase hsp3101; Catalyzes the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step. May play a role in detoxifying endogenously produced glyoxals. Involved in protection against reactive oxygen species (ROS) (By similarity). Belongs to the peptidase C56 family. HSP31-like subfamily.


ensembl_gene_id: O74918
symbol: rrp45
gene_biotype: protein_coding
description:
  Exosome complex component rrp45; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplas [...]


ensembl_gene_id: O74919
symbol: rnc1
gene_biotype: protein_coding
description:
  RNA-binding protein rnc1; Binds and stabilizes pmp1 mRNA and hence acts as a negative regulator of pmk1 signaling. Overexpression suppresses the Cl(-) sensitivity of calcineurin deletion.


ensembl_gene_id: O74927
symbol: met11
gene_biotype: protein_coding
description:
  Methylenetetrahydrofolate reductase 2; Major methylenetetrahydrofolate reductase required to generate the methyl groups necessary for methionine synthetase to convert homocysteine to methionine. Performs 15 to 20 percent of the total methylenetetrahydrofolate reductase activity of the cells.


ensembl_gene_id: O74940
symbol: qns1
gene_biotype: protein_coding
description:
  Putative glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family.


ensembl_gene_id: O74941
symbol: pex1
gene_biotype: protein_coding
description:
  Peroxisomal ATPase pex1; Component of the peroxisomal protein import machinery. Together with pex6, mediates the ATP-dependent relocation and recycling of the peroxisomal targeting signal-1 (PTS1) import receptor pex5 from the peroxisomal membrane to the cytosol, where it is then available for another round of protein import into the organelle (By similarity). Belongs to the AAA ATPase family.


ensembl_gene_id: O74942
symbol: cyp9
gene_biotype: protein_coding
description:
  Peptidyl-prolyl cis-trans isomerase 9; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).


ensembl_gene_id: O74944
symbol: kpa1
gene_biotype: protein_coding
description:
  DNA polymerase kappa; DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Has a role in meiosis.


ensembl_gene_id: O74945
symbol: ria1
gene_biotype: protein_coding
description:
  Ribosome assembly protein 1; GTPase involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with sdo1, may trigger the GTP-dependent release of tif6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating tif6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Inhibits GTPase activity of ribosome-bound EF-2 (By similarity); Belongs to the TRAFAC class translation factor GTPase superfamily. Classic transla [...]


ensembl_gene_id: O74946
symbol: spb70
gene_biotype: protein_coding
description:
  DNA polymerase alpha subunit B; May play an essential role at the early stage of chromosomal DNA replication by coupling the polymerase alpha/primase complex to the cellular replication machinery.


ensembl_gene_id: O74948
symbol: toa2
gene_biotype: protein_coding
description:
  Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with tbp mediates transcriptional activity (By similarity).


ensembl_gene_id: O74952
symbol: msf1
gene_biotype: protein_coding
description:
  Phenylalanine--tRNA ligase, mitochondrial; Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation.


ensembl_gene_id: O74954
symbol: cbf11
gene_biotype: protein_coding
description:
  Transcription factor cbf11; Transcription factor that behaves as a negative regulator of adhesion. Recognizes specifically the canonical CSL response element GTGA/GGAA. May also play a cbf12-antagonistic role in the regulation of a number of other important processes such as extracellular material production, colony morphogenesis, ploidy maintenance, or meiosis. Belongs to the Su(H) family.


ensembl_gene_id: O74956
symbol: mrps8
gene_biotype: protein_coding
description:
  37S ribosomal protein subunit S8, mitochondrial; Belongs to the universal ribosomal protein uS8 family.


ensembl_gene_id: O74957
symbol: ago1
gene_biotype: protein_coding
description:
  Protein argonaute; Required for G1 arrest and mating in response to nitrogen starvation. Ago1 regulation of cytokinesis and cell cycle checkpoints occurs downstream of dcr1. Required, indirectly, for regulated hyperphosphorylation of cdc2. Has a role in the RNA interference (RNAi) pathway which is important for heterochromatin formation, accurate chromosome segregation, centromere cohesion and telomere function during mitosis and meiosis. Required for silencing at the centromeres and for initiation of transcriptionally silent heterochromatin at the mating type locus. Promotes histone H [...]


ensembl_gene_id: O74958
symbol: mmi1
gene_biotype: protein_coding
description:
  YTH domain-containing protein mmi1; RNA-binding protein that recognizes and binds N6- methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs and some non-coding RNAs (By similarity). Required for elemination of certain meiosis-specific mRNAs in an early event following transcription. May bind to the cis-acting region (DSR) of the mRNA, activating the nuclear exosome which may lead to the degradation of the transcript from the 3' region.


ensembl_gene_id: O74959
symbol: SPCC736.13
gene_biotype: protein_coding
description:
  Uncharacterized oxidoreductase C736.13; Belongs to the short-chain dehydrogenases/reductases (SDR) family.


ensembl_gene_id: O74960
symbol: pil1
gene_biotype: protein_coding
description:
  Probable sphingolipid long chain base-responsive protein pil1; Negative regulator of cell wall integrity (CWI) in unstressed cells, probably by inhibiting protein kinase ksg1/ppk21 activity and regulating their downstream CWI pathways pck2-MAP kinase pathway and protein kinase gad8 pathway. Activity may be regulated by the transient increase of sphingolipid long chain bases (LCBs) during heat stress (By similarity).


ensembl_gene_id: O74962
symbol: ptk1
gene_biotype: protein_coding
description:
  Pantothenate kinase; Plays a role in the physiological regulation of the intracellular CoA concentration.


ensembl_gene_id: O74963
symbol: nca2
gene_biotype: protein_coding
description:
  Nuclear control of ATPase protein 2; Involved in the mitochondrial expression of subunits 6 and 8 of the F0-F1 ATP synthase; Belongs to the NCA2 family.


ensembl_gene_id: O74964
symbol: rsc1
gene_biotype: protein_coding
description:
  Chromatin structure-remodeling complex subunit rsc1; Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. Controls particularly membrane and organelle development genes.


ensembl_gene_id: O74965
symbol: eif21
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 2A; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl- tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner; Belongs to the WD repeat EIF2A family.


ensembl_gene_id: O74966
symbol: smg1
gene_biotype: protein_coding
description:
  Small nuclear ribonucleoprotein G; Involved in pre-mRNA splicing. Binds snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site (By similarity).


ensembl_gene_id: O74967
symbol: vps25
gene_biotype: protein_coding
description:
  Vacuolar protein-sorting-associated protein 25; Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex.


ensembl_gene_id: O74969
symbol: ght2
gene_biotype: protein_coding
description:
  High-affinity glucose transporter ght2; High-affinity glucose transporter; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.


ensembl_gene_id: O74970
symbol: usp105
gene_biotype: protein_coding
description:
  Pre-mRNA-processing factor 39; Function prior to stable branch point recognition by the U1 snRNP particle to facilitate or stabilize the U1 snRNP/5'-splice site interaction. Has a direct role in the assembly or function of a catalytically active spliceosome (By similarity); Belongs to the PRP39 family.


ensembl_gene_id: O74971
symbol: atg5
gene_biotype: protein_coding
description:
  Autophagy protein 5; Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy). Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production. Conjugation with atg12, through a ubiquitin-like conjugating system involving atg7 as an E1- like activating enzyme and atg10 as an E2- [...]


ensembl_gene_id: O74972
symbol: fyv4
gene_biotype: protein_coding
description:
  Protein fyv4, mitochondrial; Involved in telomere length regulation; Belongs to the mitochondrion-specific ribosomal protein mS41 family.


ensembl_gene_id: O74974
symbol: utp25
gene_biotype: protein_coding
description:
  U3 small nucleolar RNA-associated protein 25; DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.


ensembl_gene_id: O74977
symbol: vms1
gene_biotype: protein_coding
description:
  VMS1 homolog C1827.04; Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway. Component of an evolutionarily conserved system for ubiquitin-mediated mitochondria-associated protein degradation (MAD), which is necessary to maintain mitochondrial, cellular, and organismal viability (By similarity); Belongs to the ANKZF1/VMS1 family.


ensembl_gene_id: O74983
symbol: mms2
gene_biotype: protein_coding
description:
  Ubiquitin-conjugating enzyme spm2; Has a role in the DNA error-free postreplication repair (PRR) pathway. Lacks catalytic activity by itself. The ubc13/spm2 heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'; Belongs to the ubiquitin-conjugating enzyme family.


ensembl_gene_id: O74985
symbol: naa15
gene_biotype: protein_coding
description:
  N-terminal acetyltransferase A complex subunit nat1; Non-catalytic component of the NatA N-terminal acetyltransferase, which catalyzes acetylation of proteins beginning with Met-Ser, Met-Gly and Met-Ala. N-acetylation plays a role in normal eukaryotic translation and processing, protect against proteolytic degradation and protein turnover. nat1 anchors ard1 and nat5 to the ribosome and may present the N termini of nascent polypeptides for acetylation (By similarity).


ensembl_gene_id: O74986
symbol: ctp1
gene_biotype: protein_coding
description:
  DNA endonuclease ctp1; Endonuclease that cooperates with the MRN complex in processing meiotic and mitotic double-strand breaks by allowing the endonucleolytic removal of rec12 from the break sites and ensuring both resection and intrachromosomal association of the broken ends. Required for the formation of RPA-coated single strand DNA adjacent to the DSBs where it functions together with the MRN complex in 5'- 3' resection. Required for the repair of programmed meiotic DSBs. Involved also in an rhp51 recombinase-dependent recombinational repair pathway. Belongs to the COM1/SAE2/CtIP family.


ensembl_gene_id: O74988
symbol: cox5
gene_biotype: protein_coding
description:
  Cytochrome c oxidase polypeptide 5, mitochondrial; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembr [...]


ensembl_gene_id: O74990
symbol: cog4
gene_biotype: protein_coding
description:
  Conserved oligomeric Golgi complex subunit 4; Component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis- Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events (By similarity).


ensembl_gene_id: O74991
symbol: pof3
gene_biotype: protein_coding
description:
  F-box/TPR repeat protein pof3; Has a role in substrate recognition in the Skp1-Cullin- 1/Cdc53-F-box (SCF) ubiquitin ligase complex. Required for the maintenance of telomere length and transcriptional silencing at the telomere. Also required for chromosome segregation.


ensembl_gene_id: O74994
symbol: rng3
gene_biotype: protein_coding
description:
  Ring assembly protein 3; Essential for actinomyosin ring assembly during cytokinesis. Has a role, in conjunction with F-actin, in assembling myosin II- containing proteins, such as myo2, at the division site.


ensembl_gene_id: O74995
symbol: ssl1
gene_biotype: protein_coding
description:
  General transcription and DNA repair factor IIH subunit ssl1; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has be [...]


ensembl_gene_id: O74999
symbol: rhp7
gene_biotype: protein_coding
description:
  DNA repair protein rhp7; Involved in global genome repair (GGR) via nucleotide excision repair (NER), in conjunction with rhp16, after UV irradiation. Belongs to the RAD7 family.


ensembl_gene_id: O75001
symbol: mcm7
gene_biotype: protein_coding
description:
  DNA replication licensing factor mcm7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]


ensembl_gene_id: O75002
symbol: mog1
gene_biotype: protein_coding
description:
  Nuclear import protein mog1; Involved in the Ran-GTPase system for nuclear protein import and poly(A)+ mRNA export. Required for mitosis-to-interphase transition; Belongs to the MOG1 family.


ensembl_gene_id: O75004
symbol: cdc24
gene_biotype: protein_coding
description:
  Cell division control protein 24; Has a role in the progression of DNA replication and in the maintenance of genomic integrity. Acts during S phase, after initiation, where it is essential for completion.


ensembl_gene_id: O75006
symbol: sec15
gene_biotype: protein_coding
description:
  Exocyst complex component sec15; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane; Belongs to the SEC15 family.


ensembl_gene_id: O75011
symbol: nak1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase nak1; Has a role in the regulation of cell polarity, growth and division.


ensembl_gene_id: O94235
symbol: mph1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase mph1; Involved in the regulation of the onset of mitosis. Involved in a pathway that coordinates cell proliferation and differentiation. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.


ensembl_gene_id: O94236
symbol: moe1
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 3 subunit D; mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7- methylguanosine cap of a subset of mRNAs.


ensembl_gene_id: O94241
symbol: arp6
gene_biotype: protein_coding
description:
  Actin-like protein arp6; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability (By similarity).


ensembl_gene_id: O94242
symbol: dar2
gene_biotype: protein_coding
description:
  Aspartate--tRNA ligase, mitochondrial; Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.


ensembl_gene_id: O94244
symbol: mis16
gene_biotype: protein_coding
description:
  Histone acetyltransferase type B subunit 2; Regulatory subunit of the histone acetylase B (HAT-B) complex (By similarity). The complex acetylates 'Lys-12' of histone H4 which is required for telomeric silencing (By similarity). Component of the CENP-A recruiting complex that ensures the integrity of mitotic spindles through maintenance of kinetochore factors mis6/CENP-I and cnp1/CENP-A. Maintains the deacetylated state of histones specifically in the central core of the centromeres. Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.


ensembl_gene_id: O94247
symbol: SPCC737.07c
gene_biotype: protein_coding
description:
  DNA polymerase alpha-associated DNA helicase A; DNA polymerase alpha-associated DNA helicase which may be involved in DNA replication; Belongs to the DNA2/NAM7 helicase family.


ensembl_gene_id: O94248
symbol: mdn1
gene_biotype: protein_coding
description:
  Midasin; Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits. Functions at successive maturation steps to remove ribosomal factors at critical transition points, first driving the exit of early pre-60S particles from the nucleolus and then driving late pre-60S particles from the nucleus.


ensembl_gene_id: O94250
symbol: SPCC13B11.03c
gene_biotype: protein_coding
description:
  Probable hydroxyacylglutathione hydrolase C13B11.03c; Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl- glutathione to form glutathione and D-lactic acid.


ensembl_gene_id: O94251
symbol: pop7
gene_biotype: protein_coding
description:
  Ribonucleases P/MRP protein subunit POP7; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP, which cleaves pre-rRNA sequences (By similarity). Belongs to the histone-like Alba family.


ensembl_gene_id: O94255
symbol: nce103
gene_biotype: protein_coding
description:
  Carbonic anhydrase; Catalyzes the reversible hydration of CO(2) to H(2)CO(3). The main role may be to provide inorganic carbon for the bicarbonate- dependent carboxylation reactions catalyzed by pyruvate carboxylase, acetyl-CoA carboxylase and carbamoyl-phosphate synthetase (By similarity); Belongs to the beta-class carbonic anhydrase family.


ensembl_gene_id: O94257
symbol: ppm1
gene_biotype: protein_coding
description:
  Leucine carboxyl methyltransferase 1; Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha- leucine ester residues; Belongs to the methyltransferase superfamily. LCMT family.


ensembl_gene_id: O94258
symbol: los1
gene_biotype: protein_coding
description:
  Exportin-T; tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease (By similarity).


ensembl_gene_id: O94259
symbol: utp16
gene_biotype: protein_coding
description:
  Probable U3 small nucleolar RNA-associated protein 16; Involved in nucleolar processing of pre-18S ribosomal RNA.


ensembl_gene_id: O94261
symbol: fta3
gene_biotype: protein_coding
description:
  Inner kinetochore subunit fta3; Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly (By similarity). Fta2, fta3 and fta4 associate with the central core (cnt) and inner repeat (inr) region of the centromere.


ensembl_gene_id: O94262
symbol: vac7
gene_biotype: protein_coding
description:
  Vacuolar segregation protein 7; Component of the PI(3,5)P2 regulatory complex that regulates both the synthesis and turnover of phosphatidylinositol 3,5- bisphosphate (PtdIns(3,5)P2). Directly involved in vacuolar membrane scission. Required for normal vacuole acidification, inheritance and morphology (By similarity).


ensembl_gene_id: O94263
symbol: dpb2
gene_biotype: protein_coding
description:
  DNA polymerase epsilon subunit B; As accessory component of the DNA polymerase epsilon (DNA polymerase II) participates in chromosomal DNA replication. Belongs to the DNA polymerase epsilon subunit B family.


ensembl_gene_id: O94265
symbol: SPBP8B7.17c
gene_biotype: protein_coding
description:
  Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 1; Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. In the N-terminal section; belongs to the ThiD family.


ensembl_gene_id: O94266
symbol: SPBP8B7.18c
gene_biotype: protein_coding
description:
  Putative hydroxymethylpyrimidine/phosphomethylpyrimidine kinase 2; Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. In the N-terminal section; belongs to the ThiD family.


ensembl_gene_id: O94267
symbol: spt16
gene_biotype: protein_coding
description:
  FACT complex subunit spt16; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...]


ensembl_gene_id: O94268
symbol: nop2
gene_biotype: protein_coding
description:
  25S rRNA (cytosine-C(5))-methyltransferase nop2; S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of a cytosine in 25S rRNA. Required for 60S ribosomal subunit synthesis and processing (By similarity).


ensembl_gene_id: O94270
symbol: erd2
gene_biotype: protein_coding
description:
  ER lumen protein-retaining receptor; Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi (By similarity); Belongs to the ERD2 family.


ensembl_gene_id: O94272
symbol: atg8
gene_biotype: protein_coding
description:
  Autophagy-related protein 8; Ubiquitin-like modifier involved in autophagosomes formation. With atg4, mediates the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Participates also in membrane fusion events that take place in the early secretory pathway. Also involved [...]


ensembl_gene_id: O94273
symbol: cyp4
gene_biotype: protein_coding
description:
  Peptidyl-prolyl cis-trans isomerase B; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity); Belongs to the cyclophilin-type PPIase family. PPIase B subfamily.


ensembl_gene_id: O94275
symbol: mug30
gene_biotype: protein_coding
description:
  Probable E3 ubiquitin-protein ligase mug30; Probable E3 ubiquitin-protein ligase. Has a role in meiosis.


ensembl_gene_id: O94277
symbol: abz1
gene_biotype: protein_coding
description:
  Putative aminodeoxychorismate synthase; Catalyzes the biosynthesis of 4-amino-4-deoxychorismate (ADC) from chorismate and glutamine. Required for the synthesis of 4- aminobenzoate (PABA), an important component in tetrahydrofolate biosynthesis (By similarity); In the C-terminal section; belongs to the anthranilate synthase component I family.


ensembl_gene_id: O94278
symbol: thi5
gene_biotype: protein_coding
description:
  Thiamine repressible genes regulatory protein thi5; Transcription factor that activates the nmt1 promoter. Regulation of thiamine repressible genes. Negatively regulates conjugation during meiosis, by inducing negative regulators which delay conjugation. Involved in thi1 regulation.


ensembl_gene_id: O94279
symbol: SPBP8B7.31
gene_biotype: protein_coding
description:
  Putative magnesium-dependent phosphatase P8B7.31; Magnesium-dependent phosphatase which may act as a tyrosine phosphatase.


ensembl_gene_id: O94281
symbol: ckb2
gene_biotype: protein_coding
description:
  Probable casein kinase II subunit beta-2; Plays a complex role in regulating the basal catalytic activity of the alpha subunit.


ensembl_gene_id: O94282
symbol: ctu1
gene_biotype: protein_coding
description:
  Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated urm1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation; Belongs to the TtcA family. CTU1/NCS6/A [...]


ensembl_gene_id: O94283
symbol: erv41
gene_biotype: protein_coding
description:
  ER-derived vesicles protein 41; Constituent of COPII-coated endoplasmic reticulum-derived transport vesicles. Required for efficient transport of a subset of secretory proteins to the Golgi. Facilitates retrograde transport from the Golgi to the endoplasmic reticulum (By similarity); Belongs to the ERGIC family.


ensembl_gene_id: O94284
symbol: hmt2
gene_biotype: protein_coding
description:
  Sulfide:quinone oxidoreductase, mitochondrial; Catalyzes the oxidation of hydrogen sulfide, with the help of a quinone.


ensembl_gene_id: O94285
symbol: rpc25
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerase III subunit rpc8; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNA.


ensembl_gene_id: O94286
symbol: adi1
gene_biotype: protein_coding
description:
  1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).


ensembl_gene_id: O94287
symbol: SPBC887.02
gene_biotype: protein_coding
description:
  Uncharacterized chloride channel protein C887.02; Voltage-gated chloride channel; Belongs to the chloride channel (TC 2.A.49) family.


