# geneInfo

ensembl_gene_id: O94288
symbol: noc3
gene_biotype: protein_coding
description:
  Nucleolar complex-associated protein 3; May be required for synthesis of 60S ribosomal subunits and the transport of pre-ribosomes from the nucleoplasm to the cytoplasm. Belongs to the CBF/MAK21 family.


ensembl_gene_id: O94289
symbol: lub1
gene_biotype: protein_coding
description:
  Ubiquitin homeostasis protein lub1; Acts as a negative regulator of vacuole-dependent ubiquitin degradation.


ensembl_gene_id: O94291
symbol: snx3
gene_biotype: protein_coding
description:
  Sorting nexin-3; Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)) (By similarity).


ensembl_gene_id: O94295
symbol: pus2
gene_biotype: protein_coding
description:
  tRNA pseudouridine synthase 2; Formation of pseudouridine at positions 27 and 28 in the anticodon stem and loop of transfer RNAs; at positions 34 and 36 of intron-containing precursor tRNA(Ile) and at position 35 in the intron- containing tRNA(Tyr); Belongs to the tRNA pseudouridine synthase TruA family.


ensembl_gene_id: O94296
symbol: SPBC887.12
gene_biotype: protein_coding
description:
  Probable phospholipid-transporting ATPase C887.12; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids.


ensembl_gene_id: O94297
symbol: cem1
gene_biotype: protein_coding
description:
  Putative 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial; May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function. Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.


ensembl_gene_id: O94298
symbol: sur2
gene_biotype: protein_coding
description:
  Sphingolipid C4-hydroxylase sur2; Required for hydroxylation of C-4 in the sphingoid moiety of ceramide. Involved in the response to syringomycin (By similarity).


ensembl_gene_id: O94301
symbol: hfi1
gene_biotype: protein_coding
description:
  Transcriptional coactivator hfi1; Functions as component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and SLIK. SAGA is involved in RNA polymerase II-dependent transcriptional regulation. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. SAGA acetylates nucleoso [...]


ensembl_gene_id: O94302
symbol: rft1
gene_biotype: protein_coding
description:
  Oligosaccharide translocation protein rft1; May participate in the translocation of oligosaccharide from the cytoplasmic side to the lumenal side of the endoplasmic reticulum membrane; Belongs to the RFT1 family.


ensembl_gene_id: O94303
symbol: his4
gene_biotype: protein_coding
description:
  Imidazole glycerol phosphate synthase hisHF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain. In the C-terminal section; belongs to the HisA/HisF family.


ensembl_gene_id: O94305
symbol: mgl1
gene_biotype: protein_coding
description:
  Putative monoglyceride lipase; Converts monoacylglycerides (MAG) to free fatty acids and glycerol. Required for efficient degradation of MAG, short-lived intermediates of glycerolipid metabolism which may also function as lipid signaling molecules; Belongs to the AB hydrolase superfamily. Monoacylglycerol lipase family.


ensembl_gene_id: O94307
symbol: pfd5
gene_biotype: protein_coding
description:
  Probable prefoldin subunit 5; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity). Required for normal cytoskeletal function and when bound to byr1, is involved in the regulation of sexual differentiation; Belongs to the prefoldin subunit alpha family.


ensembl_gene_id: O94308
symbol: csn1
gene_biotype: protein_coding
description:
  COP9 signalosome complex subunit 1; Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin- protein ligase complexes (By similarity). Required, indirectly, for activation of ribonucleotide reductase through the degradation of the protein spd1, thereby supplying deoxyribonucleotides for DNA replication and repair; Belongs to the CSN1 family.


ensembl_gene_id: O94316
symbol: cwf10
gene_biotype: protein_coding
description:
  Pre-mRNA-splicing factor cwf10; Component of the U5 snRNP complex required for pre-mRNA splicing. Binds GTP; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.


ensembl_gene_id: O94318
symbol: vps20
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 20; Class E VPS protein implicated in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles. The lumenal sequestrated membrane proteins will be targeted into the vacuole after fusion of the endosome with the vacuole.


ensembl_gene_id: O94319
symbol: sec13
gene_biotype: protein_coding
description:
  Protein transport protein sec13; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. It also functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport facto [...]


ensembl_gene_id: O94320
symbol: maa1
gene_biotype: protein_coding
description:
  Aspartate aminotransferase, mitochondrial; Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol (By similarity). Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.


ensembl_gene_id: O94321
symbol: mpr1
gene_biotype: protein_coding
description:
  Multistep phosphorelay regulator 1; Binds to the msc4 response regulator which is part of a multistep phosphorelay system that transmits oxidative stress signals to the spc1 MAPK cascade.


ensembl_gene_id: O94324
symbol: ppk31
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase ppk31; Has a role in meiosis; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.


ensembl_gene_id: O94325
symbol: pex5
gene_biotype: protein_coding
description:
  Peroxisomal targeting signal receptor; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import.


ensembl_gene_id: O94327
symbol: tps0
gene_biotype: protein_coding
description:
  Translocator protein homolog; May play a role in the transport of porphyrins and heme. Belongs to the TspO/BZRP family.


ensembl_gene_id: O94329
symbol: psf2
gene_biotype: protein_coding
description:
  DNA replication complex GINS protein psf2; The GINS complex plays an essential role in the initiation of DNA replication. Has a role in chromosome segregation and is required for bir1 localization.


ensembl_gene_id: O94330
symbol: arg6
gene_biotype: protein_coding
description:
  Amino-acid acetyltransferase, mitochondrial; N-acetylglutamate synthase involved in arginine biosynthesis. Belongs to the acetyltransferase family.


ensembl_gene_id: O94331
symbol: ura5
gene_biotype: protein_coding
description:
  Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP); Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.


ensembl_gene_id: O94332
symbol: rrn11
gene_biotype: protein_coding
description:
  RNA polymerase I-specific transcription initiation factor rrn11; Subunit of a multiprotein complex essential for the initiation of rDNA transcription by RNA polymerase I. Binding to the DNA template is dependent on the initial binding of other factors.


ensembl_gene_id: O94335
symbol: stt3
gene_biotype: protein_coding
description:
  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit stt3; Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation  [...]


ensembl_gene_id: O94337
symbol: dys1
gene_biotype: protein_coding
description:
  Probable deoxyhypusine synthase; Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.


ensembl_gene_id: O94346
symbol: aga1
gene_biotype: protein_coding
description:
  Arginine biosynthesis bifunctional protein ArgJ, mitochondrial; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate.


ensembl_gene_id: O94347
symbol: nnr2
gene_biotype: protein_coding
description:
  ATP-dependent (S)-NAD(P)H-hydrate dehydratase; Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.


ensembl_gene_id: O94348
symbol: SPCC61.04c
gene_biotype: protein_coding
description:
  Protein transport protein yip1; Required for fusion of ER-derived vesicles with the Golgi during ER-to-Golgi protein transport, probably by mediating correct membrane localization of ypt1.


ensembl_gene_id: O94353
symbol: apq12
gene_biotype: protein_coding
description:
  Nuclear membrane organization protein apq12; Involved in the regulation of lipid homeostasis in the endoplasmic reticulum, thereby impacting nuclear pore complex biogenesis and localization, and nucleocytoplasmic mRNA transport. Belongs to the APQ12 family.


ensembl_gene_id: O94355
symbol: rxt2
gene_biotype: protein_coding
description:
  Transcriptional regulatory protein rxt2; Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity); Belongs to the RXT2 family.


ensembl_gene_id: O94360
symbol: mob1
gene_biotype: protein_coding
description:
  Maintenance of ploidy protein mob1; Has a role in promoting the onset of septum formation during the latter stages of mitosis; Belongs to the MOB1/phocein family.


ensembl_gene_id: O94363
symbol: rhb1
gene_biotype: protein_coding
description:
  GTP-binding protein rhb1; Regulates entry into stationary phase when extracellular nitrogen levels are adequate for growth; Belongs to the small GTPase superfamily. Rheb family.


ensembl_gene_id: O94364
symbol: wpl1
gene_biotype: protein_coding
description:
  Wings apart-like protein homolog 1; Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Belongs to the WAPL family.


ensembl_gene_id: O94365
symbol: utp15
gene_biotype: protein_coding
description:
  U3 small nucleolar RNA-associated protein 15; Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I together with a subset of U3 proteins required for transcription (t- UTPs) (By similarity).


ensembl_gene_id: O94368
symbol: ppr1
gene_biotype: protein_coding
description:
  Pentatricopeptide repeat-containing protein 1, mitochondrial; Mitochondrial RNA-binding protein required for the stability of the cox2 and cox3 mRNAs.


ensembl_gene_id: O94373
symbol: atp4
gene_biotype: protein_coding
description:
  ATP synthase subunit 4, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the cent [...]


ensembl_gene_id: O94374
symbol: imp1
gene_biotype: protein_coding
description:
  Importin subunit alpha-2; Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope. Involved in nuclear protein import. Required for efficient nuclera import of both an SV [...]


ensembl_gene_id: O94375
symbol: rex4
gene_biotype: protein_coding
description:
  RNA exonuclease 4; Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs (By similarity); Belongs to the REXO4 family.


ensembl_gene_id: O94376
symbol: srb7
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.


ensembl_gene_id: O94377
symbol: atp17
gene_biotype: protein_coding
description:
  ATP synthase subunit f, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the centr [...]


ensembl_gene_id: O94379
symbol: mrpl32
gene_biotype: protein_coding
description:
  Probable 54S ribosomal protein L32, mitochondrial; Component of the large subunit of mitochondrial ribosome. Belongs to the bacterial ribosomal protein bL32 family.


ensembl_gene_id: O94380
symbol: gpi16
gene_biotype: protein_coding
description:
  GPI transamidase component PIG-T homolog; Component of the GPI transamidase complex. Involved in transfer of GPI to proteins (By similarity).


ensembl_gene_id: O94383
symbol: psm1
gene_biotype: protein_coding
description:
  Structural maintenance of chromosomes protein 1; Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.


ensembl_gene_id: O94385
symbol: pom152
gene_biotype: protein_coding
description:
  Nucleoporin pom152; Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors (By similarity).


ensembl_gene_id: O94390
symbol: atp7
gene_biotype: protein_coding
description:
  ATP synthase subunit d, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the cent [...]


ensembl_gene_id: O94391
symbol: cyb502
gene_biotype: protein_coding
description:
  Probable cytochrome b5 1; Membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases; Belongs to the cytochrome b5 family.


ensembl_gene_id: O94393
symbol: nas2
gene_biotype: protein_coding
description:
  Probable 26S proteasome regulatory subunit p27; Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the 19S regulatory complex (RC).


ensembl_gene_id: O94395
symbol: pku70
gene_biotype: protein_coding
description:
  ATP-dependent DNA helicase II subunit 1; Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. ku70, of the ku70/ku80 heterodimer, binds to the stem loop of tlc1, the RNA component of telomerase. R [...]


ensembl_gene_id: O94396
symbol: pus1
gene_biotype: protein_coding
description:
  tRNA pseudouridine synthase 1; Formation of pseudouridine at positions 27 and 28 in the anticodon stem and loop of transfer RNAs; at positions 34 and 36 of intron-containing precursor tRNA(Ile) and at position 35 in the intron- containing tRNA(Tyr). Catalyzes pseudouridylation at position 44 in U2 snRNA (By similarity). Also catalyzes pseudouridylation of mRNAs (By similarity). Belongs to the tRNA pseudouridine synthase TruA family.


ensembl_gene_id: O94397
symbol: sgf73
gene_biotype: protein_coding
description:
  SAGA-associated factor 73; Functions as component of the transcription regulatory histone acetylation (HAT) complex SAGA. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA [...]


ensembl_gene_id: O94398
symbol: mrpl17
gene_biotype: protein_coding
description:
  54S ribosomal protein L17, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mL46 family.


ensembl_gene_id: O94399
symbol: twf1
gene_biotype: protein_coding
description:
  Twinfilin; Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G- actin. Prevents actin filament assembly by forming a 1:1 complex with actin monomers, and inhibits the nucleotide exchange reaction of actin monomers (By similarity).


ensembl_gene_id: O94402
symbol: zip2
gene_biotype: protein_coding
description:
  Probable zinc transporter zip2; Probable zinc transporter that may mediate zinc remobilization from the endoplasmic reticulum under zinc limitation. Belongs to the ZIP transporter (TC 2.A.5) family.


ensembl_gene_id: O94406
symbol: prp18
gene_biotype: protein_coding
description:
  Pre-mRNA-splicing factor 18; Participates in the second step of pre-mRNA splicing. Belongs to the PRP18 family.


ensembl_gene_id: O94407
symbol: sec65
gene_biotype: protein_coding
description:
  Signal recognition particle sec65 subunit; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. It must be involved intimately in the translocation of a wide variety of protein substrates (By similarity); Belongs to the SRP19 family.


ensembl_gene_id: O94408
symbol: lsm2
gene_biotype: protein_coding
description:
  U6 snRNA-associated Sm-like protein LSm2; Binds specifically to the 3'-terminal U-tract of U6 snRNA.


ensembl_gene_id: O94411
symbol: fzr3
gene_biotype: protein_coding
description:
  Meiotic fizzy-related protein 2; Has a role in meiosis; Belongs to the WD repeat CDC20/Fizzy family.


ensembl_gene_id: O94412
symbol: bet4
gene_biotype: protein_coding
description:
  Geranylgeranyl transferase type-2 subunit alpha; Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to proteins having the C-terminal-XCC or -XCXC, where both cysteines may become modified.


ensembl_gene_id: O94413
symbol: SPCC1620.06c
gene_biotype: protein_coding
description:
  Ribose-phosphate pyrophosphokinase 2; 5-phosphoribose 1-diphosphate synthase involved in nucleotide, histidine, and tryptophan biosynthesis. Active in heteromultimeric complexes with other 5-phosphoribose 1-diphosphate synthases (By similarity); Belongs to the ribose-phosphate pyrophosphokinase family.


ensembl_gene_id: O94414
symbol: lnp1
gene_biotype: protein_coding
description:
  Endoplasmic reticulum junction formation protein lunapark; Plays a role in tubular endoplasmic reticulum network formation and maintenance; Belongs to the lunapark family.


ensembl_gene_id: O94415
symbol: lsc2
gene_biotype: protein_coding
description:
  Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.


ensembl_gene_id: O94416
symbol: tfg1
gene_biotype: protein_coding
description:
  Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation (By similarity).


ensembl_gene_id: O94418
symbol: nup97
gene_biotype: protein_coding
description:
  Meiotically up-regulated gene 87 protein; Has a role in meiosis; Belongs to the nucleoporin interacting component (NIC) family.


ensembl_gene_id: O94421
symbol: snf22
gene_biotype: protein_coding
description:
  SWI/SNF chromatin-remodeling complex subunit snf22; Helicase. Component of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors.


ensembl_gene_id: O94423
symbol: mfr1
gene_biotype: protein_coding
description:
  Meiotic fizzy-related protein 1; Meiosis-specific activator of the anaphase promoting complex/cyclosome (APC/C). Involved in cdc13 degradation.


ensembl_gene_id: O94424
symbol: tfg2
gene_biotype: protein_coding
description:
  Transcription initiation factor IIF subunit beta; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation (By similarity).


ensembl_gene_id: O94429
symbol: mef2
gene_biotype: protein_coding
description:
  Ribosome-releasing factor 2, mitochondrial; Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Not involved in the GTP-dependent ribosomal translocation step during translation elongation; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.


ensembl_gene_id: O94431
symbol: egt2
gene_biotype: protein_coding
description:
  Hercynylcysteine sulfoxide lyase; Catalyzes the conversion of hercynylcysteine sulfoxide to ergothioneine by cleaving the cysteine residue at the sulfur atom, the last step in the biosynthesis pathway of ergothioneine. Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. EgtE subfamily.


ensembl_gene_id: O94436
symbol: tfg3
gene_biotype: protein_coding
description:
  Transcription initiation factor TFIID subunit 14; Functions as a component of the DNA-binding general transcription factor complex TFIID, and the RNA polymerase II associated general transcription factor complex TFIIF. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, facilitation of DNA op [...]


ensembl_gene_id: O94442
symbol: nbp35
gene_biotype: protein_coding
description:
  Cytosolic Fe-S cluster assembly factor nbp35; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The nbp35-cfd1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.


ensembl_gene_id: O94444
symbol: rpn10
gene_biotype: protein_coding
description:
  26S proteasome regulatory subunit rpn10; Protects ubiquitin chains against dissambly by deubiquitinating enzymes thereby promoting protein degradation.


ensembl_gene_id: O94445
symbol: rpm2
gene_biotype: protein_coding
description:
  ATP-dependent RNA helicase suv3, mitochondrial; Required for intron-independent turnover and processing of mitochondrial RNA. It is a key control element in nuclear-mitochondrial interactions (By similarity).


ensembl_gene_id: O94446
symbol: mst1
gene_biotype: protein_coding
description:
  Histone acetyltransferase mst1; Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac. Acetylation of histone H4 is essential for DNA double-strand break repair through homologous recombination. Involved in cell cycle progression. Recruitment to promoters depends on  [...]


ensembl_gene_id: O94447
symbol: slm1
gene_biotype: protein_coding
description:
  Cytoskeletal signaling protein slm1; Effector of the TORC2- and calcineurin-signaling pathways. Mediates actin polarization via inhibition of calcineurin-dependent transcription (By similarity).


ensembl_gene_id: O94448
symbol: rce1
gene_biotype: protein_coding
description:
  Probable CAAX prenyl protease 2; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase U48 family.


ensembl_gene_id: O94449
symbol: rfc4
gene_biotype: protein_coding
description:
  Replication factor C subunit 4; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1.


ensembl_gene_id: O94451
symbol: pli1
gene_biotype: protein_coding
description:
  E3 SUMO-protein ligase pli1; Acts as an E3 ligase mediating SUMO/Smt3 attachment to other proteins. Involved in the maintenance of the centromere and in telomere length. Regulates recombination, via extension sumoylation, particularly within the heterochromatin repeats. Belongs to the PIAS family.


ensembl_gene_id: O94453
symbol: coq4
gene_biotype: protein_coding
description:
  Ubiquinone biosynthesis protein coq4, mitochondrial; Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides.


ensembl_gene_id: O94454
symbol: csn5
gene_biotype: protein_coding
description:
  COP9 signalosome complex subunit 5; Catalytic Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes; Belongs to the peptidase M67A family. CSN5 subfamily.


ensembl_gene_id: O94457
symbol: erg31
gene_biotype: protein_coding
description:
  Delta(7)-sterol 5(6)-desaturase erg31; Catalyzes the introduction of a C-5 double bond in the B ring of ergosterol. Involved in the biosynthesis or ergosterol which is important for plasma membrane structure and function and for localization of plasma membrane proteins. Belongs to the sterol desaturase family.


ensembl_gene_id: O94459
symbol: ssl3
gene_biotype: protein_coding
description:
  MAU2 chromatid cohesion factor homolog; Involved in sister chromatid cohesion. Forms a complex with mis4, which is required for the association of the cohesin complex with chromosomes.


ensembl_gene_id: O94460
symbol: qtr1
gene_biotype: protein_coding
description:
  Queuine tRNA-ribosyltransferase catalytic subunit; Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming [...]


ensembl_gene_id: O94462
symbol: puf3
gene_biotype: protein_coding
description:
  mRNA-binding protein puf3; RNA-binding protein involved in post-transcriptional regulation. Predominantly binds to mRNAs encoding mitochondrial proteins and localizes them to the vicinity of mitochondria for translation. Regulates mitochondrial biogenesis, motility and morphology (By similarity); Belongs to the PUF3 family.


ensembl_gene_id: O94465
symbol: cms1
gene_biotype: protein_coding
description:
  Protein cms1; May play a role in the regulation of DNA replication and cell cycle control; Belongs to the CMS1 family.


ensembl_gene_id: O94468
symbol: mag2
gene_biotype: protein_coding
description:
  Probable DNA-3-methyladenine glycosylase 2; Involved in base excision repair of methyl methanesulfonate- damaged DNA by hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine or 7-methyladenine from the damaged DNA polymer formed by alkylation lesions.


ensembl_gene_id: O94469
symbol: SPBC23G7.13c
gene_biotype: protein_coding
description:
  Probable urea active transporter 1; Involved in active transport of urea; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.


ensembl_gene_id: O94472
symbol: pbn1
gene_biotype: protein_coding
description:
  Protein pbn1; Required for proper folding and/or the stability of a subset of proteins in the endoplasmic reticulum. Component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase gpi14 (By similarity).


ensembl_gene_id: O94476
symbol: tif6
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export; Belongs to the eIF-6 family.


ensembl_gene_id: O94477
symbol: myo52
gene_biotype: protein_coding
description:
  Myosin-52; Involved in cell wall deposition where it has a role in the localization of mok1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.


ensembl_gene_id: O94480
symbol: bmt5
gene_biotype: protein_coding
description:
  25S rRNA (uridine-N(3))-methyltransferase; S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(3) position of a uridine in 25S rRNA.


ensembl_gene_id: O94483
symbol: dad5
gene_biotype: protein_coding
description:
  High osmolarity sensitivity protein 3; May play a role in the progression of mitosis in an environment of high osmotic stress.


ensembl_gene_id: O94487
symbol: mug27
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase ppk35; Has a role in meiosis; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.


ensembl_gene_id: O94488
symbol: mto1
gene_biotype: protein_coding
description:
  Microtubule organizer protein 1; Required for cytoplasmic astral microtubule growth during mitosis. Involved in localizing components of the gamma-tubulin complex to the non-spindle pole body (non-SPB) microtubule organizing centers (MTOCs). Required for new microtubule nucleation from non-SPB sites during interphase.


ensembl_gene_id: O94489
symbol: tef3
gene_biotype: protein_coding
description:
  Elongation factor 3; The main role of EF-3 may be to transduce nucleoside triphosphate energy into mechanical energy for translocation during translation. EF-3 stimulates EF-1-alpha-dependent binding of aminoacyl- tRNA to the ribosome.


ensembl_gene_id: O94492
symbol: SPCC417.11c
gene_biotype: protein_coding
description:
  Uncharacterized aminotransferase C417.11c; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.


ensembl_gene_id: O94494
symbol: sim4
gene_biotype: protein_coding
description:
  Inner kinetochore subunit sim4; Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly. Belongs to the CENP-K/MCM22 family.


ensembl_gene_id: O94495
symbol: elp5
gene_biotype: protein_coding
description:
  Elongator complex protein 5; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation (By similarity). The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5- carbamoylmethyl uridine) (By similarity). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs ; Belongs to the ELP5 family.


ensembl_gene_id: O94501
symbol: cct1
gene_biotype: protein_coding
description:
  T-complex protein 1 subunit alpha; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity).


ensembl_gene_id: O94503
symbol: srb11
gene_biotype: protein_coding
description:
  RNA polymerase II holoenzyme cyclin-like subunit; Component of the Cdk8 module/Srb8-11 module which is a regulatory module of the Mediator complex that regulates basal RNA polymerase II transcription. The Cdk8 module may sterically hinder the interaction between Mediator and RNA polymerase II leading to transcriptional repression of a subset of genes regulated by Mediator.


ensembl_gene_id: O94504
symbol: trx2
gene_biotype: protein_coding
description:
  Thioredoxin-2, mitochondrial; Disulfide reductase which serves multiple functions in mitochondria, protecting mitochondrial components against thiol- oxidative damage as a thiol-disulfide oxidoreductase, and supporting urea cycle and respiration in mitochondria in a manner independent of active site thiols.


ensembl_gene_id: O94505
symbol: tol1
gene_biotype: protein_coding
description:
  3'(2'),5'-bisphosphate nucleotidase; Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. Regulates the flux of sulfur in the sulfur- activation pathway by converting PAPS to APS. Belongs to the inositol monophosphatase superfamily.


ensembl_gene_id: O94508
symbol: cwf11
gene_biotype: protein_coding
description:
  Pre-mRNA-splicing factor cwf11; Involved in mRNA splicing where it associates with cdc5 and the other cwf proteins as part of the spliceosome; Belongs to the CWF11 family.


ensembl_gene_id: O94509
symbol: gta1
gene_biotype: protein_coding
description:
  Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Belongs to the amidase family. GatA subfamily.


ensembl_gene_id: O94513
symbol: int6
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation (Potential). Required for maintaining the basal level of atf1 and for transcriptional activation of core environmental stress response genes (CESR genes) i [...]


ensembl_gene_id: O94515
symbol: cct6
gene_biotype: protein_coding
description:
  T-complex protein 1 subunit zeta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity).


ensembl_gene_id: O94516
symbol: pex16
gene_biotype: protein_coding
description:
  Peroxisomal membrane protein PEX16; Involved in the biogenesis of peroxisomes; Belongs to the peroxin-16 family.


ensembl_gene_id: O94517
symbol: scl1
gene_biotype: protein_coding
description:
  Probable proteasome subunit alpha type-1; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity); Belongs to the peptidase T1A family.


ensembl_gene_id: O94518
symbol: dic1
gene_biotype: protein_coding
description:
  Dynein intermediate chain 1; Has a role in meiotic nuclear divsion where it promotes the movement of 'horsetails'; Belongs to the dynein intermediate chain family.


ensembl_gene_id: O94521
symbol: akr7
gene_biotype: protein_coding
description:
  Probable pyridoxal reductase 2; Catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+).


ensembl_gene_id: O94522
symbol: rsc7
gene_biotype: protein_coding
description:
  Chromatin structure-remodeling complex subunit rsc7; Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. Controls particularly membrane and organelle development genes.


ensembl_gene_id: O94523
symbol: ole1
gene_biotype: protein_coding
description:
  Probable acyl-CoA desaturase; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA. Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides.


ensembl_gene_id: O94524
symbol: gst4
gene_biotype: protein_coding
description:
  Glutathione S-transferase omega-like 2; Active as '1-Cys' thiol transferase against beta-hydroxyethyl disulfide (HED), as dehydroascorbate reductase and as dimethylarsinic acid reductase, while not active against the standard GST substrate 1- chloro-2,4-dinitrobenzene (CDNB). May be involved in cell wall organization and biogenesis (By similarity); Belongs to the GST superfamily. Omega family.


ensembl_gene_id: O94526
symbol: ptn1
gene_biotype: protein_coding
description:
  Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase ptn1; Acts as a phosphoinositide 3-phosphatase and regulates PtdIns(3,4,5)P3 levels.


ensembl_gene_id: O94527
symbol: iqw1
gene_biotype: protein_coding
description:
  WD repeat protein iqw1; Ligand-dependent coactivator of nuclear receptors that may function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.


ensembl_gene_id: O94529
symbol: pob3
gene_biotype: protein_coding
description:
  FACT complex subunit pob3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...]


ensembl_gene_id: O94530
symbol: sua5
gene_biotype: protein_coding
description:
  Threonylcarbamoyl-AMP synthase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Likely catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. Required for normal translation, by ensuring translation fidelity at the level of codon recognition, appropriate translation initiation selection and maintenance of reading frame. Also involved in telomere replication. Binds to single-st [...]


ensembl_gene_id: O94531
symbol: ufe1
gene_biotype: protein_coding
description:
  Syntaxin ufe1; Syntaxin required for targeting and fusion of Golgi-derived retrograde transport vesicles with the ER; Belongs to the syntaxin family.


ensembl_gene_id: O94532
symbol: for3
gene_biotype: protein_coding
description:
  Formin-3; Involved in controlling polarized cell growth. Required for interphase actin cable formation and microtubule organization. Belongs to the formin homology family.


ensembl_gene_id: O94533
symbol: elp2
gene_biotype: protein_coding
description:
  Elongator complex protein 2; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation (By similarity). The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5- carbamoylmethyl uridine) (By similarity). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs ; Belongs to the WD repeat [...]


ensembl_gene_id: O94534
symbol: alp14
gene_biotype: protein_coding
description:
  Spindle pole body component alp14; Required for bipolar spindle formation and proper chromosome segregation. Has a role in connecting the kinetochores and the plus end of pole to chromosome microtubules. Also required for the activation of the spindle checkpoint pathway; Belongs to the TOG/XMAP215 family.


ensembl_gene_id: O94538
symbol: snu66
gene_biotype: protein_coding
description:
  U4/U6.U5 tri-snRNP-associated protein snu66; Required for efficient splicing of pre-mRNA. Belongs to the SNU66/SART1 family.


ensembl_gene_id: O94539
symbol: pam17
gene_biotype: protein_coding
description:
  Presequence translocated-associated motor subunit pam17, mitochondrial; Component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.


ensembl_gene_id: O94544
symbol: lap2
gene_biotype: protein_coding
description:
  Leucine aminopeptidase 2; Aminopeptidase that preferentially cleaves di- and tripeptides. Also has low epoxide hydrolase activity (in vitro). Can hydrolyze the epoxide leukotriene LTA(4) but it forms preferentially 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid rather than the cytokine leukotriene B(4) as the product compared to the homologous mammalian enzyme (in vitro).


ensembl_gene_id: O94545
symbol: kap113
gene_biotype: protein_coding
description:
  Importin beta-like protein kap113; Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope. Involved in the export of mRNA from the nucleus to the cytoplasm. May play a r [...]


ensembl_gene_id: O94547
symbol: srk1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase srk1; Has a role in the regulation of meiosis via the sty1 stress- activated MAPK pathway. Inhibits nitrogen-limitation induced arrest at G1; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.


ensembl_gene_id: O94548
symbol: SPCC1322.09
gene_biotype: protein_coding
description:
  Maintenance of telomere capping protein 1; Involved in telomere capping; Belongs to the MTC1 family.


ensembl_gene_id: O94550
symbol: phb2
gene_biotype: protein_coding
description:
  Prohibitin-2; Prohibitin probably acts as a holdase/unfoldase for the stabilization of newly synthesized mitochondrial proteins.


ensembl_gene_id: O94552
symbol: fum1
gene_biotype: protein_coding
description:
  Fumarate hydratase, mitochondrial; Catalyzes the reversible stereospecific interconversion of fumarate to L-malate. In mitochondrion, catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH. In cytoplasm and nucleus, involved in DNA repair in response to DNA damage: following DNA double-strand breaks (DSBs), translocates from the cytosol to the nucleus and promotes DNA repair by catalyzing the dehydration of L-malate to fumarate. Belongs to the class-II fumarase/aspartase famil [...]


ensembl_gene_id: O94553
symbol: rpc34
gene_biotype: protein_coding
description:
  Probable DNA-directed RNA polymerase III subunit rpc6; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.


ensembl_gene_id: O94556
symbol: cut23
gene_biotype: protein_coding
description:
  Anaphase-promoting complex subunit 8; Component of the anaphase-promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. Has a role in promoting metaphase to anaphase transition via the ubiquitination of specific mitotic substrates.


ensembl_gene_id: O94561
symbol: bcp1
gene_biotype: protein_coding
description:
  Peroxiredoxin bcp1; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events (By similarity). Acts as a scavenger of H(2)O(2).


ensembl_gene_id: O94563
symbol: SPBC1773.04
gene_biotype: protein_coding
description:
  Putative uncharacterized oxidoreductase C1773.04; Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.


ensembl_gene_id: O94565
symbol: omh4
gene_biotype: protein_coding
description:
  O-glycoside alpha-1,2-mannosyltransferase homolog 4; Probable mannosyltransferase involved in O-glycosylation of cell wall and secreted proteins. Transfers an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha- (1->2)-D-mannosyl-D-mannose linkage; Belongs to the glycosyltransferase 15 family.


ensembl_gene_id: O94567
symbol: nrs1
gene_biotype: protein_coding
description:
  Probable asparagine--tRNA ligase, cytoplasmic; Cytosolic asparaginyl-tRNA synthetase which catalyzes the specific attachment of asparagine to its cognate tRNA.


ensembl_gene_id: O94570
symbol: SPBC1773.13
gene_biotype: protein_coding
description:
  Aromatic amino acid aminotransferase C1773.13; Has aromatic amino acid transaminase activity. Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.


ensembl_gene_id: O94574
symbol: gor2
gene_biotype: protein_coding
description:
  Putative 2-hydroxyacid dehydrogenase C1773.17c; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.


ensembl_gene_id: O94577
symbol: SPCC1442.04c
gene_biotype: protein_coding
description:
  Reduced meiotic recombination protein C1442.04c; Required for normal levels of gene conversion events during meiosis; Belongs to the RMR1 family.


ensembl_gene_id: O94579
symbol: pre8
gene_biotype: protein_coding
description:
  Probable proteasome subunit alpha type-2; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity); Belongs to the peptidase T1A family.


ensembl_gene_id: O94581
symbol: cox12
gene_biotype: protein_coding
description:
  Cytochrome c oxidase subunit 12, mitochondrial; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane [...]


ensembl_gene_id: O94584
symbol: pps1
gene_biotype: protein_coding
description:
  CDP-diacylglycerol--serine O-phosphatidyltransferase; Phosphatidylserine synthase involved in the regulation of processes such as cell morphology, cytokinesis, actin cytoskeleton, and cell wall remodeling and integrity. Also plays a role in the physiological adaptations required for stationary-phase survival. Belongs to the CDP-alcohol phosphatidyltransferase class-I family.


ensembl_gene_id: O94585
symbol: sqs2
gene_biotype: protein_coding
description:
  Meiotically up-regulated protein C1442.13c; Has a role in meiosis and sporulation. Required for meiotic chromosome segregation.


ensembl_gene_id: O94586
symbol: hnt1
gene_biotype: protein_coding
description:
  Hit family protein 1; Hydrolyzes adenosine 5'-monophosphoramidate substrates such as AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester and AMP-NH2.


ensembl_gene_id: O94587
symbol: cox18
gene_biotype: protein_coding
description:
  Cytochrome c oxidase assembly protein cox18, mitochondrial; Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome c oxidase. Plays a central role in the translocation and export of the C-terminal part of the cox2 protein into the mitochondrial intermembrane space. Belongs to the OXA1/ALB3/YidC family.


ensembl_gene_id: O94590
symbol: sec1
gene_biotype: protein_coding
description:
  Protein transport protein sec1; Involved in the final stage of protein secretion. Belongs to the STXBP/unc-18/SEC1 family.


ensembl_gene_id: O94598
symbol: sec5
gene_biotype: protein_coding
description:
  Exocyst complex component sec5; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.


ensembl_gene_id: O94600
symbol: tti1
gene_biotype: protein_coding
description:
  TEL2-interacting protein 1; Component of the TORC1 and TORC2 complexes required for the regulation of the cellular respons to changes in available nutrients.


ensembl_gene_id: O94603
symbol: epe1
gene_biotype: protein_coding
description:
  Putative JmjC domain-containing histone demethylation protein 1; May be a histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code (By similarity). Represses transcriptional silencing by negatively affecting heterochromatin stability.


ensembl_gene_id: O94607
symbol: str2
gene_biotype: protein_coding
description:
  Siderophore iron transporter 2; Involved in the transport of siderophore iron and so has a role in iron homeostasis; Belongs to the major facilitator superfamily.


ensembl_gene_id: O94609
symbol: ptr3
gene_biotype: protein_coding
description:
  Ubiquitin-activating enzyme E1 1; Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP.


ensembl_gene_id: O94613
symbol: tah18
gene_biotype: protein_coding
description:
  NADPH-dependent diflavin oxidoreductase 1; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe-S cluster of dre2. Positively controls H(2)O(2)-induced cell death; In the N-terminal section; belongs to the flavodoxin family.


ensembl_gene_id: O94614
symbol: chr4
gene_biotype: protein_coding
description:
  Chitin synthase regulatory factor 4; Involved in septum formation. Required for the proper localization of chs2 at the septum.


ensembl_gene_id: O94615
symbol: ppr8
gene_biotype: protein_coding
description:
  Pentatricopeptide repeat-containing protein 8, mitochondrial; Mitochondrial RNA-binding protein involved in mitochondrial translation. The cox1 mRNA is one target but it is not clear if ppr8 has a single or multiple targets.


ensembl_gene_id: O94616
symbol: rpc40
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerases I and III subunit RPAC1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. RPAC1 is part of the Pol core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity).


ensembl_gene_id: O94618
symbol: tim21
gene_biotype: protein_coding
description:
  Mitochondrial import inner membrane translocase subunit tim21; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to keep the TOM and the TIM23 complexes in close contact. At some point, it is released from the TOM23 complex to allow protein translocation into the mitochondrial matrix (By similarity).


ensembl_gene_id: O94619
symbol: adn2
gene_biotype: protein_coding
description:
  Adhesion defective protein 2; Probable transcriptional regulator involved in cell adhesion. Belongs to the FLO8 family.


ensembl_gene_id: O94620
symbol: spf38
gene_biotype: protein_coding
description:
  Pre-mRNA-splicing factor cwf17; Involved in mRNA splicing where it associates with cdc5 and the other cwf proteins as part of the spliceosome.


ensembl_gene_id: O94623
symbol: rev1
gene_biotype: protein_coding
description:
  DNA repair protein rev1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents. Involved in mitochondrial DNA mutagenesis (By similarity).


ensembl_gene_id: O94624
symbol: tim54
gene_biotype: protein_coding
description:
  Mitochondrial import inner membrane translocase subunit tim54; Essential component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin- pore translocase that uses the membrane potential as external driving force (By similarity).


ensembl_gene_id: O94626
symbol: rex2
gene_biotype: protein_coding
description:
  Probable oligoribonuclease; 3'-to-5' exoribonuclease specific for small oligoribonucleotides; Belongs to the oligoribonuclease family.


ensembl_gene_id: O94627
symbol: rnh202
gene_biotype: protein_coding
description:
  Ribonuclease H2 subunit B; Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes (By similarity).


ensembl_gene_id: O94628
symbol: SPBC1347.09
gene_biotype: protein_coding
description:
  Uncharacterized methyltransferase C1347.09; Probable methyltransferase; Belongs to the methyltransferase superfamily.


ensembl_gene_id: O94629
symbol: sro1
gene_biotype: protein_coding
description:
  Stress-responsive protein 1; Stress-responsive protein that may play a role in regulation of cell cycle.


ensembl_gene_id: O94630
symbol: arp1
gene_biotype: protein_coding
description:
  Centractin; Core component of the dynactin complex which assists cytoplasmic dynein by increasing its processivity and by regulation of its cargo binding. The dynactin complex is required for the spindle translocation late in anaphase and is involved in a cell wall synthesis checkpoint. Arp1 forms the backbone filament of the dynactin rod structure and serves as the scaffold for the remaining subunits. Required for proper orientation of the mitotic spindle (By similarity).


ensembl_gene_id: O94631
symbol: mrm1
gene_biotype: protein_coding
description:
  rRNA methyltransferase 1, mitochondrial; S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of the 2'-O- methylguanosine corresponding to position 2270 in S.cerevisiae 21S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA.


ensembl_gene_id: O94632
symbol: egt1
gene_biotype: protein_coding
description:
  L-histidine N(alpha)-methyltransferase; Catalyzes the SAM-dependent triple methylation of the alpha- amino group of histidine to form hercynine and subsequent conjugation with cysteine and oxygen to form hercynylcysteine sulfoxide, the first two steps in the biosynthesis pathway of ergothioneine. May play a role in meiosis. In the C-terminal section; belongs to the EgtB family.


ensembl_gene_id: O94633
symbol: dpm3
gene_biotype: protein_coding
description:
  Dolichol-phosphate mannosyltransferase subunit 3; Stabilizer subunit of the dolichol-phosphate-mannose synthase complex.


ensembl_gene_id: O94636
symbol: trm11
gene_biotype: protein_coding
description:
  tRNA (guanine(10)-N2)-methyltransferase; Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM11 methyltransferase family.


ensembl_gene_id: O94637
symbol: kae1
gene_biotype: protein_coding
description:
  tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Pgp2 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. Th [...]


ensembl_gene_id: O94639
symbol: zrt1
gene_biotype: protein_coding
description:
  Zinc-regulated transporter 1; High-affinity zinc transport protein. Regulates intracellular zinc levels; Belongs to the ZIP transporter (TC 2.A.5) family.


ensembl_gene_id: O94640
symbol: sir2
gene_biotype: protein_coding
description:
  NAD-dependent histone deacetylase sir2; Involved in silencing within the mating-type region, at the telomeres, and according to also within centromeric DNA regions. Required for the localization of swi6 to the telomeres, silent mating type region, and according to to the centromeric DNA regions. According to not required for the localization of swi6 to centromeric foci. Deacetylates histone H3 on 'Lys-9' and 'Lys-16' of histone H4. This has a direct role in heterochromatin assembly; Belongs to the sirtuin family. Class I subfamily.


ensembl_gene_id: O94641
symbol: hsp104
gene_biotype: protein_coding
description:
  Heat shock protein 104; Required, in concert with Hsp40 and Hsp70 and small Hsps, for the dissociation, resolubilization and refolding of aggregates of damaged proteins after heat or other environmental stresses. Extracts proteins from aggregates by unfolding and threading them in an ATP- dependent process through the axial channel of the protein hexamer, after which they can be refolded by components of the Hsp70/Hsp40 chaperone system (By similarity).


ensembl_gene_id: O94642
symbol: tad2
gene_biotype: protein_coding
description:
  tRNA-specific adenosine deaminase subunit tad2; Deaminates adenosine-34 to inosine in many tRNAs. Belongs to the cytidine and deoxycytidylate deaminase family. ADAT2 subfamily.


ensembl_gene_id: O94643
symbol: mis17
gene_biotype: protein_coding
description:
  Inner kinetochore subunit mis17; Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore COMA complex, which connects centromere-associated proteins and the outer kinetochore. COMA interacts with other inner kinetochore proteins to form the inner kinetochore constitutive centromere- associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.


ensembl_gene_id: O94644
symbol: rtc5
gene_biotype: protein_coding
description:
  Restriction of telomere capping protein 5; May be involved in a process influencing telomere capping. Belongs to the RTC5 family.


ensembl_gene_id: O94646
symbol: med8
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 8; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.


ensembl_gene_id: O94647
symbol: ppk24
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase ppk24, mitochondrial; Has a role late in meiosis; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.


ensembl_gene_id: O94649
symbol: atg2
gene_biotype: protein_coding
description:
  Autophagy-related protein 2; Required for cytoplasm to vacuole transport (Cvt) vesicles and autophagosomes completion and peroxisome degradation (By similarity). Appears to have a role in sporulation.


ensembl_gene_id: O94650
symbol: hub1
gene_biotype: protein_coding
description:
  Ubiquitin-like modifier hub1; Forms a conjugate with snu66 and facilitates its localization to the nucleus. Involved in morphogenesis. Required for efficient splicing of pre-mRNA.


ensembl_gene_id: O94651
symbol: pep12
gene_biotype: protein_coding
description:
  Syntaxin pep12; Has a role in vesicle-mediated transport but not with protein transport from Golgi to vesicle; Belongs to the syntaxin family.


ensembl_gene_id: O94652
symbol: gle1
gene_biotype: protein_coding
description:
  Nucleoporin gle1; Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. It is specifically involved in a terminal step of poly(A)+ mRNA transport through the NPC (By similarity).


ensembl_gene_id: O94653
symbol: bms1
gene_biotype: protein_coding
description:
  Ribosome biogenesis protein bms1; May act as a molecular switch during maturation of the 40S ribosomal subunit in the nucleolus; Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. BMS1 subfamily.


ensembl_gene_id: O94655
symbol: ypt7
gene_biotype: protein_coding
description:
  GTP-binding protein ypt7; Needed for homotypic vacuole fusion, the last step in the vacuole inheritance process; Belongs to the small GTPase superfamily. Rab family.


ensembl_gene_id: O94656
symbol: atg16
gene_biotype: protein_coding
description:
  Autophagy protein 16; Stabilizes the atg5-atg12 conjugate and mediates the formation of the 350 kDa complex, which is necessary for autophagy. The atg5-atg12/atg16 complex is required for efficient promotion of atg8- conjugation to phosphatidylethanolamine and atg8 localization to the preautophagosomal structure (PAS). Involved in endoplasmic reticulum- specific autophagic process and is essential for the survival of cells subjected to severe ER stress. Required for meiotic chromosome segregation.


ensembl_gene_id: O94659
symbol: nog1
gene_biotype: protein_coding
description:
  Probable nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.


ensembl_gene_id: O94661
symbol: gyp10
gene_biotype: protein_coding
description:
  GTPase-activating protein gyp10; Has a role in vesicular trafficking and septation during cytokinesis.


ensembl_gene_id: O94663
symbol: dot2
gene_biotype: protein_coding
description:
  Vacuolar-sorting protein dot2; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Negatively regulates meiotic spindle pole body maturation via indirect regulation of the pcp1 gene. Required for efficient entry into pre-meiotic S phase.


ensembl_gene_id: O94666
symbol: rpc1
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerase III subunit rpc1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single- stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to pro [...]


ensembl_gene_id: O94667
symbol: prf1
gene_biotype: protein_coding
description:
  RNA polymerase-associated protein C651.09c; The PAF1 complex is a multifunctional complex. Involved in transcription initiation via genetic interactions with TATA-binding proteins. Involved in elongation. Also has a role in transcription- coupled histone modification. Important for TATA site selection by TBP. Directly or indirectly regulates the DNA-binding properties of the TATA box-binding protein, and the relative activities of different TATA elements (By similarity).


ensembl_gene_id: O94668
symbol: nse5
gene_biotype: protein_coding
description:
  Non-structural maintenance of chromosome element 5; Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks. May prevent formation of excessive Holliday junctions or assist in their resolution.


ensembl_gene_id: O94669
symbol: apm3
gene_biotype: protein_coding
description:
  AP-3 complex subunit mu; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to the vacuole (By similarity); Belongs to the adaptor complexes medium subunit family.


ensembl_gene_id: O94672
symbol: sec2302
gene_biotype: protein_coding
description:
  Protein transport protein sec23-2; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity).


ensembl_gene_id: O94673
symbol: gpc1
gene_biotype: protein_coding
description:
  Glycerophosphocholine acyltransferase 1; Glycerophosphocholine acyltransferase (GPCAT) that utilizes acyl-CoA to acylate glycero-3-phosphocholine (GPC), forming lysophosphatidylcholine (LPC) (By similarity). Shows broad acyl specificities with a preference for 16:0-CoA, polyunsaturated acyl-CoA, and the hydroxylated ricinoleoyl-CoA (By similarity). Catalyzes also the acylation of glycero-3-phosphoethanolamine (GPE) with acyl-CoA (By similarity). In addition to acyl-CoA, GPCAT efficiently utilizes LPC and lysophosphatidylethanolamine (LPE) as acyl donors in the acylation of GPC (By simi [...]


ensembl_gene_id: O94676
symbol: utp22
gene_biotype: protein_coding
description:
  U3 small nucleolar RNA-associated protein 22; Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.


ensembl_gene_id: O94677
symbol: cog6
gene_biotype: protein_coding
description:
  Conserved oligomeric Golgi complex subunit 6; Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events (By similarity); Belongs to the COG6 family.


ensembl_gene_id: O94679
symbol: cnd1
gene_biotype: protein_coding
description:
  Condensin complex subunit 1; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. The condensin complex probably also plays a role during interphase.


ensembl_gene_id: O94680
symbol: plh1
gene_biotype: protein_coding
description:
  Phospholipid:diacylglycerol acyltransferase; Triacylglycerol formation by an acyl-CoA independent pathway. The enzyme specifically transfers acyl groups from the sn-2 position of a phospholipid to diacylglycerol, thus forming an sn-1- lysophospholipid. Plays a major role in triacylglycerol formation at log phase. Cells defective in triacylglycerol synthesis undergo apoptosis upon entry into the stationary phase. Generation of reactive oxygen species (ROS) is essential to lipoapoptosis. Belongs to the AB hydrolase superfamily. Lipase family.


ensembl_gene_id: O94681
symbol: kgd2
gene_biotype: protein_coding
description:
  2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase); The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).


ensembl_gene_id: O94682
symbol: mis20
gene_biotype: protein_coding
description:
  CENP-A recruiting complex protein mis20; Component of the CENP-A recruiting complex that ensures the integrity of mitotic spindles through maintenance of kinetochore factors mis6/CENP-I and cnp1/CENP-A. Seems dispensable for proper chromosome segregation.


ensembl_gene_id: O94683
symbol: rrp7
gene_biotype: protein_coding
description:
  Ribosomal RNA-processing protein 7; Plays an important role in the synthesis of 18S rRNA but is not required for the 5.8S and 25S pathway. Is necessary for the cleavage at site A2 (By similarity); Belongs to the RRP7 family.


ensembl_gene_id: O94684
symbol: pmh1
gene_biotype: protein_coding
description:
  RNA polymerase II transcription factor B subunit 3; Acts as component of the general transcription and DNA repair factor IIH (TFIIH or factor B), which is essential for both basal and activated transcription, and is involved in nucleotide excision repair (NER) of damaged DNA. TFIIH has CTD kinase activity and DNA-dependent ATPase activity, and is essential for polymerase II transcription (By similarity).


ensembl_gene_id: O94687
symbol: tas3
gene_biotype: protein_coding
description:
  RNA-induced transcriptional silencing complex protein tas3; Has a role in the RNA interference (RNAi) pathway which is important for heterochromatin formation and accurate chromosome segregation. A member of the RNA-induced transcriptional silencing (RITS) complex which is involved in the biosynthesis of dsRNA from primer siRNAs provided by the RNA-directed RNA polymerase (RDRC) complex.


ensembl_gene_id: O94688
symbol: apc15
gene_biotype: protein_coding
description:
  Anaphase-promoting complex subunit 15; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome.


ensembl_gene_id: O94689
symbol: SPBC83.05
gene_biotype: protein_coding
description:
  Mitochondrial escape protein 2; Plays a role in maintaining the mitochondrial genome and in controlling the mtDNA escape. Involved in the regulation of mtDNA nucleotide structure and number. May have a dispensable role in early maturation of pre-rRNA (By similarity); Belongs to the YME2 family.


ensembl_gene_id: O94690
symbol: rtc6
gene_biotype: protein_coding
description:
  54S ribosomal protein c83.06c, mitochondrial; Belongs to the bacterial ribosomal protein bL36 family.


ensembl_gene_id: O94692
symbol: rvb2
gene_biotype: protein_coding
description:
  RuvB-like helicase 2; DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity); Belongs to the RuvB family.


ensembl_gene_id: O94697
symbol: rfc5
gene_biotype: protein_coding
description:
  Replication factor C subunit 5; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1.


ensembl_gene_id: O94699
symbol: SPBC83.16c
gene_biotype: protein_coding
description:
  Inclusion body clearance protein IML2; Inclusion body (IB) resident protein that interacts strongly with lipid droplet (LD) proteins. Involved in LD-mediated IB clearing after protein folding stress, probably by enabling access to the IBs of an LD-stored soluble sterol derivative that acts as chaperone in inclusion clearing.


ensembl_gene_id: O94700
symbol: mbf1
gene_biotype: protein_coding
description:
  Multiprotein-bridging factor 1; Transcriptional coactivator that stimulates transcriptional activity by bridging regulatory proteins and TBP, thereby recruiting TBP to promoters occupied by DNA-binding regulators.


ensembl_gene_id: O94701
symbol: fic1
gene_biotype: protein_coding
description:
  Ingression protein fic1; Involved in the ingression of the plasma membrane during cytokinesis, leading to the separation of the daughter cells. Unlike its S.cerevisiae ortholog INN1, it does not play an essential role, probably because the actinomyosin ring is connected to the cell cortex by many more proteins.


ensembl_gene_id: O94702
symbol: erm1
gene_biotype: protein_coding
description:
  Putative endoplasmic reticulum metallopeptidase 1; Belongs to the peptidase M28 family. M28B subfamily.


ensembl_gene_id: O94703
symbol: rpa12
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerase I subunit RPA12; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Required for growth at higher temperatures. Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.


ensembl_gene_id: O94704
symbol: iec3
gene_biotype: protein_coding
description:
  INO80 complex subunit 3; Component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.


ensembl_gene_id: O94705
symbol: cox9
gene_biotype: protein_coding
description:
  Cytochrome c oxidase subunit 9, mitochondrial; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane  [...]


ensembl_gene_id: O94706
symbol: taf8
gene_biotype: protein_coding
description:
  Transcription initiation factor TFIID subunit 8; Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification, facilitation of DNA opening and initiation of transcription (By similarity).


ensembl_gene_id: O94707
symbol: rxt3
gene_biotype: protein_coding
description:
  Transcriptional regulatory protein rxt3; Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity).


ensembl_gene_id: O94709
symbol: pdx1
gene_biotype: protein_coding
description:
  Probable pyruvate dehydrogenase protein X component, mitochondrial; Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex (By similarity).


ensembl_gene_id: O94710
symbol: pgp1
gene_biotype: protein_coding
description:
  tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.


ensembl_gene_id: O94711
symbol: gyp2
gene_biotype: protein_coding
description:
  GTPase-activating protein gyp2; Stimulates specifically the GTPase activity of ypt2 and ryh1. Inactivates ryh1 during recycling between the endosome and the Golgi compartments (By similarity).


ensembl_gene_id: O94714
symbol: spt2
gene_biotype: protein_coding
description:
  Protein spt2; Histone chaperone that stabilizes pre-existing histone tetramers and regulates replication-independent histone exchange on chromatin. Required for normal chromatin refolding in the coding region of transcribed genes, and for the suppression of spurious transcription. Global regulatory protein that plays positive as well as negative regulatory roles in transcription. Belongs to the SPT2 family.


ensembl_gene_id: O94716
symbol: fta4
gene_biotype: protein_coding
description:
  Inner kinetochore subunit fta4; Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly. Fta2, fta3 and fta4 associate with the central core (cnt) and inner repeat (inr) region of the centromere.


ensembl_gene_id: O94717
symbol: ers1
gene_biotype: protein_coding
description:
  RNA-silencing factor ers1; Involved in RNAi-dependent heterochromatin formation and centromeric silencing. Required for the conversion of centromeric pre- small interfering RNA transcripts into small interfering RNAs, histone H3 'Lys9' methylation, and the recruitment of the RITS complex to centromeric sequences.


ensembl_gene_id: O94718
symbol: ipi1
gene_biotype: protein_coding
description:
  Pre-rRNA-processing protein ipi1; Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.


ensembl_gene_id: O94722
symbol: ctr4
gene_biotype: protein_coding
description:
  Copper transport protein ctr4; Required for high affinity copper (probably reduced Cu I) transport into the cell.


ensembl_gene_id: O94725
symbol: duf89
gene_biotype: protein_coding
description:
  Damage-control phosphatase SPCC1393.13; Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate (By similarity). Its preference for fructose-1- phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism (By similarity).


ensembl_gene_id: O94726
symbol: mnl1
gene_biotype: protein_coding
description:
  ER degradation-enhancing alpha-mannosidase-like protein 1; Alpha-mannosidase-like protein involved in endoplasmic reticulum-associated degradation (ERAD). Delivers misfolded glycoproteins to proteasomes. It lacks mannosidase activity. Belongs to the glycosyl hydrolase 47 family.


ensembl_gene_id: O94727
symbol: frp2
gene_biotype: protein_coding
description:
  Ferric/cupric reductase transmembrane component 2; Metalloreductase responsible for reducing extracellular iron and copper prior to import (By similarity). Catalyzes the reductive uptake of Fe(3+)-salts and Fe(3+) bound to catecholate or hydroxamate siderophores (By similarity). Fe(3+) is reduced to Fe(2+), which then dissociates from the siderophore and can be imported by the high- affinity Fe(2+) transport complex in the plasma membrane (By similarity). Also participates in Cu(2+) reduction and Cu(+) uptake (By similarity).


ensembl_gene_id: O94731
symbol: trs8501
gene_biotype: protein_coding
description:
  Transport protein particle subunit trs85-1; Component of the TRAPP I and TRAPP II complexes. TRAPP I plays a key role in the late stages of endoplasmic reticulum to Golgi traffic. TRAPP II seems to play a role in intra-Golgi transport. Has a role late in meiosis following DNA replication (By similarity).


ensembl_gene_id: O94740
symbol: cdc37
gene_biotype: protein_coding
description:
  Hsp90 co-chaperone Cdc37; Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity.


ensembl_gene_id: O94744
symbol: git3
gene_biotype: protein_coding
description:
  Glucose receptor protein git3; Activates gpa2 when triggered by glucose and then activates adenylate cyclase; Belongs to the G-protein coupled receptor GPR1/git3 family.


ensembl_gene_id: O94745
symbol: mas2
gene_biotype: protein_coding
description:
  Probable mitochondrial-processing peptidase subunit alpha; Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.


ensembl_gene_id: O94751
symbol: bub1
gene_biotype: protein_coding
description:
  Checkpoint serine/threonine-protein kinase bub1; Involved in cell cycle checkpoint enforcement. Acts to stabilize the spindle during mitosis. Required for the correct localization of bub3 and mad3 to the kinetochore. Appears to have a role in chromosome segregation. Catalyzes the phosphorylation of bub3.


ensembl_gene_id: O94752
symbol: edc3
gene_biotype: protein_coding
description:
  Enhancer of mRNA-decapping protein 3; Stimulates decapping of both stable and unstable mRNA during mRNA decay. Stimulates decapping presumably by preventing the DCP1-DCP2 decapping complex from adopting an inactive conformation. Belongs to the EDC3 family.


ensembl_gene_id: O94756
symbol: meu14
gene_biotype: protein_coding
description:
  Meiotic expression up-regulated protein 14; Has a role in nuclear division during meiosis II where it stabilizes the proper segregation of the spindle pole bodies. Also has a role in the formation and extension of the forespore membrane.


ensembl_gene_id: P00046
symbol: cyc1
gene_biotype: protein_coding
description:
  Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.


ensembl_gene_id: P01129
symbol: cdc10
gene_biotype: protein_coding
description:
  Start control protein cdc10; Major component of the cell cycle transcription factor complex MBF (MCB binding factor, also known as DSC1), that controls G1- S phase specific gene expression. Involved in the control of rRNA production, via interaction with pol5. May be involved in the transcriptional regulation of the cdc22 and cdt1 genes. In fission yeast, two genes, cdc10 and cdc2, are required for the cell cycle control called start, the point early in the G1 phase at which cells become committed to the mitotic cycle.


ensembl_gene_id: P04551
symbol: cdc2
gene_biotype: protein_coding
description:
  Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle. It is required for entry into S-phase and mitosis. When complexed with cig2, plays a role in G1-S phase transition. When activated and complexed with the cyclin cdc13, it leads to the onset of mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II. Involved in cell cycle arrest induced by defective RNA splicing. Required for phosphorylation of dis1 to ensure accurate chromosome segregation and for the DNA damage checkpoint.


ensembl_gene_id: P04688
symbol: nda2
gene_biotype: protein_coding
description:
  Tubulin alpha-1 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.


ensembl_gene_id: P04689
symbol: atb2
gene_biotype: protein_coding
description:
  Tubulin alpha-2 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.


ensembl_gene_id: P04909
symbol: hta1
gene_biotype: protein_coding
description:
  Histone H2A-alpha; Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.


ensembl_gene_id: P04910
symbol: hta2
gene_biotype: protein_coding
description:
  Histone H2A-beta; Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.


ensembl_gene_id: P04913
symbol: htb1
gene_biotype: protein_coding
description:
  Histone H2B-alpha; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.


ensembl_gene_id: P05219
symbol: nda3
gene_biotype: protein_coding
description:
  Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.


ensembl_gene_id: P05501
symbol: cob1
gene_biotype: protein_coding
description:
  Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.


ensembl_gene_id: P05764
symbol: rps21
gene_biotype: protein_coding
description:
  40S ribosomal protein S21; Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Has a physiological role leading to 18S rRNA stability. Belongs to the eukaryotic ribosomal protein eS21 family.


ensembl_gene_id: P05933
symbol: cam1
gene_biotype: protein_coding
description:
  Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.


ensembl_gene_id: P06652
symbol: cdc25
gene_biotype: protein_coding
description:
  M-phase inducer phosphatase; This protein functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It may directly dephosphorylate p34(cdc2) and activate the p34(cdc2) kinase activity.


ensembl_gene_id: P07334
symbol: cdr1
gene_biotype: protein_coding
description:
  Mitosis inducer protein kinase cdr1; This protein, a dose-dependent mitotic inducer, appears to function as a negative regulator of mitosis inhibitor wee1 by phosphorylating and inactivating it.


ensembl_gene_id: P07527
symbol: wee1
gene_biotype: protein_coding
description:
  Mitosis inhibitor protein kinase wee1; Protein kinase that acts both on serines and on tyrosines. It acts as a dosage-dependent negative regulator of entry into mitosis (G2 to M transition). Phosphorylates and inhibits cdc2. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.


ensembl_gene_id: P07657
symbol: cox1
gene_biotype: protein_coding
description:
  Cytochrome c oxidase subunit 1; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...]


ensembl_gene_id: P07799
symbol: top1
gene_biotype: protein_coding
description:
  DNA topoisomerase 1; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)- enzyme intermediate and the expulsion of a 5'-OH DNA strand. TThe free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus rem [...]


ensembl_gene_id: P08090
symbol: mei3
gene_biotype: protein_coding
description:
  21 kDa protein inducing meiosis and sporulation; This protein, expressed under control of the mating-type locus, induces meiosis and sporulation in fission yeast. It down regulates the ran1/pat1 gene product.


ensembl_gene_id: P08092
symbol: pat1
gene_biotype: protein_coding
description:
  Negative regulator of sexual conjugation and meiosis; This protein is a negative regulator of both sexual conjugation and meiosis. It phosphorylates mei2. It blocks the onset of meiosis until conjugation takes place.


ensembl_gene_id: P08094
symbol: rpp201
gene_biotype: protein_coding
description:
  60S acidic ribosomal protein P2-alpha; Plays an important role in the elongation step of protein synthesis; Belongs to the eukaryotic ribosomal protein P1/P2 family.


ensembl_gene_id: P08096
symbol: top2
gene_biotype: protein_coding
description:
  DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.


ensembl_gene_id: P08463
symbol: suc1
gene_biotype: protein_coding
description:
  Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinase (cdc2) and is essential for its biological function; Belongs to the CKS family.


ensembl_gene_id: P08647
symbol: ras1
gene_biotype: protein_coding
description:
  Ras-like protein 1; Participates in the process of sexual differentiation and the determination of cell shape. Essential for mating and for recognition of the mating pheromone, but not for vegetative growth. Does not regulate the intracellular cAMP level. Regulates two downstream pathways, namely the byr2/byr1/spk1 mitogen-activated protein kinase cascade and the cdc42 small G protein pathway. The former is relevant to mating and sporulation, whereas the latter is relevant to mating, cell growth and cell morphology.


ensembl_gene_id: P08965
symbol: mei2
gene_biotype: protein_coding
description:
  Meiosis protein mei2; Crucial for commitment to meiosis but it is not sufficient itself for the commitment. May be a splicing regulator.


ensembl_gene_id: P09322
symbol: hhf1
gene_biotype: protein_coding
description:
  Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.


ensembl_gene_id: P09627
symbol: pma1
gene_biotype: protein_coding
description:
  Plasma membrane ATPase 1; The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses.


ensembl_gene_id: P09988
symbol: hht1
gene_biotype: protein_coding
description:
  Histone H3.1/H3.2; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.


ensembl_gene_id: P0C016
symbol: ubi3
gene_biotype: protein_coding
description:
  Ubiquitin-40S ribosomal protein S27a; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be invo [...]


ensembl_gene_id: P0C8R3
symbol: ubi5
gene_biotype: protein_coding
description:
  Ubiquitin-40S ribosomal protein S27b; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be invo [...]


ensembl_gene_id: P0CAN8
symbol: nxt1
gene_biotype: protein_coding
description:
  NTF2-related export protein 1; Stimulator of protein export for NES-containing proteins (By similarity). Also plays a role in mRNA nuclear export.


ensembl_gene_id: P0CF96
symbol: mzt1
gene_biotype: protein_coding
description:
  Mitotic-spindle organizing protein 1; Required for gamma-tubulin complex recruitment to the microtubule organizing center (MTOC).


ensembl_gene_id: P0CG72
symbol: ubi4
gene_biotype: protein_coding
description:
  Polyubiquitin; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys [...]


ensembl_gene_id: P0CH06
symbol: ubi1
gene_biotype: protein_coding
description:
  Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...]


ensembl_gene_id: P0CT33
symbol: tlh1
gene_biotype: protein_coding
description:
  ATP-dependent DNA helicase tlh1; Exhibits ATP-dependent 3' to 5' DNA helicase activity and has a role in telomerase-independent telomere maintenance. Belongs to the helicase family. RecQ subfamily.


ensembl_gene_id: P0CT53
symbol: tef101
gene_biotype: protein_coding
description:
  Elongation factor 1-alpha-A; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.


ensembl_gene_id: P0CT54
symbol: tef102
gene_biotype: protein_coding
description:
  Elongation factor 1-alpha-B; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.


ensembl_gene_id: P0CT55
symbol: tef103
gene_biotype: protein_coding
description:
  Elongation factor 1-alpha-B/C; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.


ensembl_gene_id: P0CT66
symbol: rps1801
gene_biotype: protein_coding
description:
  40S ribosomal protein S18-A; Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA.


ensembl_gene_id: P0CT67
symbol: rps1802
gene_biotype: protein_coding
description:
  40S ribosomal protein S18-B; Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA.


ensembl_gene_id: P0CT77
symbol: rpl1101
gene_biotype: protein_coding
description:
  60S ribosomal protein L11-A; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome throu [...]


ensembl_gene_id: P0CT78
symbol: rpl1102
gene_biotype: protein_coding
description:
  60S ribosomal protein L11-B; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome throu [...]


ensembl_gene_id: P0CT83
symbol: rpl1201
gene_biotype: protein_coding
description:
  60S ribosomal protein L12-A; This protein binds directly to 26S ribosomal RNA. Belongs to the universal ribosomal protein uL11 family.


ensembl_gene_id: P0CT84
symbol: rpl1202
gene_biotype: protein_coding
description:
  60S ribosomal protein L12-B; This protein binds directly to 26S ribosomal RNA. Belongs to the universal ribosomal protein uL11 family.


ensembl_gene_id: P0CU02
symbol: plb4
gene_biotype: protein_coding
description:
  Putative lysophospholipase SPAC977.09c; Catalyzes the release of fatty acids from lysophospholipids.


ensembl_gene_id: P0CU03
symbol: SPBC1348.10c
gene_biotype: protein_coding
description:
  Putative lysophospholipase SPBC1348.10c; Catalyzes the release of fatty acids from lysophospholipids.


ensembl_gene_id: P0CU04
symbol: SPBC1348.08c
gene_biotype: protein_coding
description:
  Putative cell agglutination protein SPAC1348.08c; May be involved in agglutination during conjugation or other aspects of colony formation.


ensembl_gene_id: P0CU05
symbol: pfl6
gene_biotype: protein_coding
description:
  Putative cell agglutination protein pfl6; May be involved in agglutination during conjugation or other aspects of colony formation (By similarity). Induces flocculation when overexpressed ; Belongs to the mam3/map4 family.


ensembl_gene_id: P0CU17
symbol: rpn501
gene_biotype: protein_coding
description:
  26S proteasome regulatory subunit rpn501; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. Required for proper proteasome assembly.


ensembl_gene_id: P0CU18
symbol: rpn502
gene_biotype: protein_coding
description:
  26S proteasome regulatory subunit rpn502; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. Required for proper proteasome assembly.


ensembl_gene_id: P0CU19
symbol: fex1
gene_biotype: protein_coding
description:
  Fluoride export protein 1; Fluoride channel required for the rapid expulsion of cytoplasmic fluoride; Belongs to the fluoride exporter Fluc/FEX family.


ensembl_gene_id: P0CU20
symbol: fex2
gene_biotype: protein_coding
description:
  Fluoride export protein 2; Fluoride channel required for the rapid expulsion of cytoplasmic fluoride; Belongs to the fluoride exporter Fluc/FEX family.


ensembl_gene_id: P0CU26
symbol: ina17
gene_biotype: protein_coding
description:
  Inner membrane assembly complex subunit 17; Component of the INA complex (INAC) that promotes the biogenesis of mitochondrial F(1)F(0)-ATP synthase. INAC facilitates the assembly of the peripheral stalk and promotes the assembly of the catalytic F(1)-domain with the membrane-embedded F(0)-domain.


ensembl_gene_id: P0CY14
symbol: mat3-Mi
gene_biotype: protein_coding
description:
  Silenced mating-type M-specific polypeptide Mi; Mating type proteins are sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion. Silenced copy of mat-Mi at mat3-M.


ensembl_gene_id: P0CY15
symbol: mat1-Mi
gene_biotype: protein_coding
description:
  Mating-type M-specific polypeptide Mi; Mating type proteins are sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion. Required for meiosis, but plays no role in conjugation.


ensembl_gene_id: P0CY16
symbol: mat3-Mc
gene_biotype: protein_coding
description:
  Silenced mating-type M-specific polypeptide Mc; Mating type proteins are sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion. Silenced copy of mat-Mc at mat3-M.


ensembl_gene_id: P0CY17
symbol: mat1-Mc
gene_biotype: protein_coding
description:
  Mating-type M-specific polypeptide Mc; Mating type proteins are sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion. Positive regulator of MFM genes. The HMG box recognizes the DNA sequence 5'- AACAAAG-3'. Required for conjugation and efficient meiosis.


ensembl_gene_id: P10505
symbol: nuc2
gene_biotype: protein_coding
description:
  Anaphase-promoting complex subunit 3; Component of the anaphase-promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. Interacts with spindle apparatus, chromosomes, or nuclear envelope, and interconnect nuclear and cytoskeletal functions in mitosis [...]


ensembl_gene_id: P10506
symbol: byr1
gene_biotype: protein_coding
description:
  Protein kinase byr1; Serine/threonine protein kinase involved in conjugation and sporulation. It is thought that it is phosphorylated by the byr2 protein kinase and that it can phosphorylate the spk1 kinase. When bound to bob1, is involved in the regulation of sexual differentiation.


ensembl_gene_id: P10651
symbol: hht3
gene_biotype: protein_coding
description:
  Histone H3.3; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.


ensembl_gene_id: P10815
symbol: cdc13
gene_biotype: protein_coding
description:
  G2/mitotic-specific cyclin cdc13; Essential for the control of the cell cycle at the G2/M (mitosis) transition. Interacts with the cdc2 protein kinase to form MPF. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis. Involved in the reorganization of the cytoskeleton on transition from G2 to mitosis. Association with rum1 promotes its proteolysis during G1.


ensembl_gene_id: P10989
symbol: act1
gene_biotype: protein_coding
description:
  Actin; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.


ensembl_gene_id: P11620
symbol: ypt1
gene_biotype: protein_coding
description:
  GTP-binding protein ypt1; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Ypt1 regulates the trafficking of secretory vesicles from the endoplasmic reticulum (ER) to the Golgi. Plays a role in the initial events of the autophagic vacuole development which take  [...]


ensembl_gene_id: P12000
symbol: cdc17
gene_biotype: protein_coding
description:
  DNA ligase 1; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair; Belongs to the ATP-dependent DNA ligase family.


ensembl_gene_id: P13681
symbol: dis2
gene_biotype: protein_coding
description:
  Serine/threonine-protein phosphatase PP1-1; Essential role in cell cycle control. PP1 is perhaps required for exit from mitosis.


ensembl_gene_id: P14068
symbol: crm1
gene_biotype: protein_coding
description:
  Exportin-1; Receptor for the leucine-rich nuclear export signal (NES). Belongs to the exportin family.


ensembl_gene_id: P14575
symbol: cox3
gene_biotype: protein_coding
description:
  Cytochrome c oxidase subunit 3; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...]


ensembl_gene_id: P14605
symbol: cyr1
gene_biotype: protein_coding
description:
  Adenylate cyclase; Plays essential roles in regulation of cellular metabolism by catalyzing the synthesis of a second messenger, cAMP.


ensembl_gene_id: P15258
symbol: ral2
gene_biotype: protein_coding
description:
  Protein ral2; Essential for mating and for recognition of the mating pheromone, and for the determination of cell shape. Implicated in activation of the ras1 protein.


ensembl_gene_id: P15398
symbol: nuc1
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerase I subunit rpa1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation o [...]


ensembl_gene_id: P15567
symbol: ade6
gene_biotype: protein_coding
description:
  Phosphoribosylaminoimidazole carboxylase; In the C-terminal section; belongs to the AIR carboxylase family. Class I subfamily.


ensembl_gene_id: P17476
symbol: rpp101
gene_biotype: protein_coding
description:
  60S acidic ribosomal protein P1-alpha 1; Plays an important role in the elongation step of protein synthesis; Belongs to the eukaryotic ribosomal protein P1/P2 family.


ensembl_gene_id: P17477
symbol: rpp102
gene_biotype: protein_coding
description:
  60S acidic ribosomal protein P1-alpha 3; Plays an important role in the elongation step of protein synthesis; Belongs to the eukaryotic ribosomal protein P1/P2 family.


ensembl_gene_id: P17478
symbol: rpp202
gene_biotype: protein_coding
description:
  60S acidic ribosomal protein P2-beta; Plays an important role in the elongation step of protein synthesis; Belongs to the eukaryotic ribosomal protein P1/P2 family.


ensembl_gene_id: P17608
symbol: ryh1
gene_biotype: protein_coding
description:
  GTP-binding protein ryh1; Has a role in retrograde traffricking of proteins from the endosome to the Golgi. Involved in protein transport to the plasma membrane. Involved in the secretory pathway where it has a role in acid phosphatase secretion. Required also in normal glycosylation trafficking pathways; Belongs to the small GTPase superfamily. Rab family.


ensembl_gene_id: P17609
symbol: ypt2
gene_biotype: protein_coding
description:
  GTP-binding protein ypt2; Protein transport. Probably involved in vesicular traffic (By similarity).


ensembl_gene_id: P17610
symbol: ypt3
gene_biotype: protein_coding
description:
  GTP-binding protein ypt3; Has a role in retrograde traffricking of proteins from the endosome to the Golgi. Involved in the secretory pathway where it has a role in acid phosphatase secretion; Belongs to the small GTPase superfamily. Rab family.


ensembl_gene_id: P17871
symbol: tbp1
gene_biotype: protein_coding
description:
  TATA-box-binding protein; General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II.


ensembl_gene_id: P18253
symbol: ppi1
gene_biotype: protein_coding
description:
  Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.


ensembl_gene_id: P18296
symbol: cut1
gene_biotype: protein_coding
description:
  Separin; Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the rad21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by securin/cut2 protein. It is also required for pointed nuclear formation.


ensembl_gene_id: P18869
symbol: leu1
gene_biotype: protein_coding
description:
  3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate; Belongs to the isocitrate and isopropylmalate dehydrogenases family.


ensembl_gene_id: P20772
symbol: ade1
gene_biotype: protein_coding
description:
  Phosphoribosylformylglycinamidine cyclo-ligase; In the N-terminal section; belongs to the GARS family.


ensembl_gene_id: P21135
symbol: cut2
gene_biotype: protein_coding
description:
  Securin; Regulatory protein, which plays a central role in chromosome stability. Probably acts by blocking the action of key proteins. During the mitosis, it blocks separase/cut1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of cut1.


ensembl_gene_id: P21534
symbol: cox2
gene_biotype: protein_coding
description:
  Cytochrome c oxidase subunit 2; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...]


ensembl_gene_id: P21535
symbol: atp6
gene_biotype: protein_coding
description:
  ATP synthase subunit a; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subuni [...]


ensembl_gene_id: P21536
symbol: atp8
gene_biotype: protein_coding
description:
  ATP synthase protein 8; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subuni [...]


ensembl_gene_id: P21537
symbol: atp9
gene_biotype: protein_coding
description:
  ATP synthase subunit 9, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the centr [...]


ensembl_gene_id: P21547
symbol: var1
gene_biotype: protein_coding
description:
  Ribosomal protein var1, mitochondrial; Essential for mitochondrial protein synthesis and required for the maturation of small ribosomal subunits.


ensembl_gene_id: P21565
symbol: srp54
gene_biotype: protein_coding
description:
  Signal recognition particle 54 kDa protein homolog; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein); Belongs to the GTP-binding SRP family. SRP54 subfamily.


ensembl_gene_id: P21696
symbol: gpd1
gene_biotype: protein_coding
description:
  Glycerol-3-phosphate dehydrogenase [NAD(+)] 1; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.


ensembl_gene_id: P21911
symbol: sdh2
gene_biotype: protein_coding
description:
  Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).


ensembl_gene_id: P22068
symbol: atp2
gene_biotype: protein_coding
description:
  ATP synthase subunit beta, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the c [...]


ensembl_gene_id: P22189
symbol: cta3
gene_biotype: protein_coding
description:
  Calcium-transporting ATPase 3; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium.


ensembl_gene_id: P22192
symbol: pac1
gene_biotype: protein_coding
description:
  Double-strand-specific pac1 ribonuclease; Digests double-stranded RNA. Converts long double-stranded RNAs into short oligonucleotides, leaving 5'-phosphates on their cleavage products. Probably inhibits mating and meiosis by degrading a specific mRNA required for sexual development.


ensembl_gene_id: P22193
symbol: rad1
gene_biotype: protein_coding
description:
  DNA damage checkpoint control protein rad1; Recombinational reparation of DNA damages induced by UV and gamma radiation.


ensembl_gene_id: P22194
symbol: sds22
gene_biotype: protein_coding
description:
  Protein phosphatase 1 regulatory subunit SDS22; Essential for the mitotic metaphase/anaphase transition. Positively modulates protein phosphatase-1, possibly by forming a repeating helical rod that is capable of enhancing a PP1-dependent dephosphorylation activity.


ensembl_gene_id: P22987
symbol: kin1
gene_biotype: protein_coding
description:
  Protein kinase kin1; Has a role in establishing the characteristic rod cell shape. Important for cell polarity and is involved in directing growth to the cell ends; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.


ensembl_gene_id: P23566
symbol: rhp6
gene_biotype: protein_coding
description:
  Ubiquitin-conjugating enzyme E2 2; Catalyzes the covalent attachment of ubiquitin to other proteins. Component of the histone H2B ubiquitin ligase complex (HULC) which plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. Also involved in postreplication repair of UV-damaged DNA, in N-end rule-dependent protein degradation and in sporulation (By similarity). Required for obr1 ubiquitination, whi [...]


ensembl_gene_id: P23635
symbol: ppa1
gene_biotype: protein_coding
description:
  Minor serine/threonine-protein phosphatase PP2A-1 catalytic subunit; Essential role in cell cycle control. PP2A may be involved in controlling the entry into mitosis, possibly acting as an inhibitor; Belongs to the PPP phosphatase family. PP-2A subfamily.


ensembl_gene_id: P23636
symbol: ppa2
gene_biotype: protein_coding
description:
  Major serine/threonine-protein phosphatase PP2A-2 catalytic subunit; Essential role in cell cycle control. PP2A may be involved in controlling the entry into mitosis, possibly acting as an inhibitor.


ensembl_gene_id: P23880
symbol: sds21
gene_biotype: protein_coding
description:
  Serine/threonine-protein phosphatase PP1-2; Essential role in cell cycle control. PP1 is perhaps required for exit from mitosis; Belongs to the PPP phosphatase family. PP-1 subfamily.


ensembl_gene_id: P24339
symbol: cut7
gene_biotype: protein_coding
description:
  Kinesin-like protein cut7; Could be a spindle pole body motor. On transition from G2 to M phase of the cell cycle, the spindle pole body duplicates; the daughter pole bodies seed microtubules which interdigitate to form a short spindle that elongates to span the nucleus at metaphase. Mutations at cut7 block spindle formation.


ensembl_gene_id: P24487
symbol: atp1
gene_biotype: protein_coding
description:
  ATP synthase subunit alpha, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the  [...]


ensembl_gene_id: P24488
symbol: php2
gene_biotype: protein_coding
description:
  Transcriptional activator hap2; Global regulator of respiratory functions in yeast cells. It belongs to a complex that binds to the sequence CCAAT located upstream of genes involved in mitochondrial electron transport.


ensembl_gene_id: P24782
symbol: dbp2
gene_biotype: protein_coding
description:
  ATP-dependent RNA helicase dbp2; ATP-dependent RNA helicase involved nonsense-mediated mRNA decay and ribosome biogenesis through rRNA processing.


ensembl_gene_id: P25009
symbol: puc1
gene_biotype: protein_coding
description:
  Cyclin puc1; Function in exit from the mitotic cycle. Contributes to negative regulation of the timing of sexual development in fission yeast, and functions at the transition between cycling and non-cycling cells. Interacts with protein kinase A.


ensembl_gene_id: P25295
symbol: gtb1
gene_biotype: protein_coding
description:
  Tubulin gamma chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly.


ensembl_gene_id: P26306
symbol: rad9
gene_biotype: protein_coding
description:
  DNA repair protein rad9; Acts in DNA repair and mutagenesis. Involved in promoting resistance to ionizing radiation and UV light, as well as regulating cell cycle progression after irradiation. Repressor of entry into mitosis that is activated by chromosome breaks.


ensembl_gene_id: P26359
symbol: msh3
gene_biotype: protein_coding
description:
  DNA mismatch repair protein msh3; Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with msh2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. Msh3 provides substrate- binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch bindi [...]


ensembl_gene_id: P26659
symbol: rad15
gene_biotype: protein_coding
description:
  General transcription and DNA repair factor IIH helicase subunit XPD; ATP-dependent 5'-3' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATP-dependent helicase activity of XPD/rad15 is required for DNA opening. [...]


ensembl_gene_id: P27574
symbol: pyp1
gene_biotype: protein_coding
description:
  Tyrosine-protein phosphatase 1; Plays a role in inhibiting the onset of mitosis. Dephosphorylates sty1/spc1 and wis1/spc2/sty2.


ensembl_gene_id: P27584
symbol: gpa1
gene_biotype: protein_coding
description:
  Guanine nucleotide-binding protein alpha-1 subunit; Implicated in the mating and sporulation pathway. Probably coupled to mating-factor receptors. May act in concert with Ras1; Belongs to the G-alpha family. G(q) subfamily.


ensembl_gene_id: P28040
symbol: pol1
gene_biotype: protein_coding
description:
  DNA polymerase alpha catalytic subunit; Polymerase alpha in a complex with DNA primase is a replicative polymerase; Belongs to the DNA polymerase type-B family.


ensembl_gene_id: P28706
symbol: rad13
gene_biotype: protein_coding
description:
  DNA repair protein rad13; Single-stranded DNA endonuclease involved in excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents. Essential for the incision step of excision-repair (Probable).


ensembl_gene_id: P28745
symbol: pim1
gene_biotype: protein_coding
description:
  Protein pim1; Promotes the exchange of Ran(spi1)-bound GDP by GTP. Involved in the control of mitosis. Regulates a variety of nuclear events, including mitotic check-point, chromosome decondensation and mRNA processing/transport.


ensembl_gene_id: P28748
symbol: spi1
gene_biotype: protein_coding
description:
  GTP-binding nuclear protein spi1; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export.


ensembl_gene_id: P28758
symbol: sod1
gene_biotype: protein_coding
description:
  Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family.


ensembl_gene_id: P28829
symbol: byr2
gene_biotype: protein_coding
description:
  Protein kinase byr2; Serine/threonine protein kinase involved in conjugation and sporulation. It is thought that it phosphorylates the byr1 protein kinase which itself phosphorylate the spk1 kinase.


ensembl_gene_id: P28876
symbol: pma2
gene_biotype: protein_coding
description:
  Plasma membrane ATPase 2; The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.


ensembl_gene_id: P29458
symbol: mcm4
gene_biotype: protein_coding
description:
  DNA replication licensing factor mcm4; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]


ensembl_gene_id: P30290
symbol: mik1
gene_biotype: protein_coding
description:
  Mitosis inhibitor protein kinase mik1; Protein kinase that acts both on serines and on tyrosines. It acts as a negative regulator of entry into mitosis (G2 to M transition). Phosphorylates and inhibits cdc2.


ensembl_gene_id: P30316
symbol: cdc6
gene_biotype: protein_coding
description:
  DNA polymerase delta catalytic subunit; Catalytic component of DNA polymerase delta (DNA polymerase III) which participates in chromosomal DNA replication. Required during synthesis of the lagging DNA strands at the replication fork, binds at/or near replication origins and moves along DNA with the replication fork. Participates in leading strand synthesis during replication initiation and termination. Has 3'-5' proofreading exonuclease activity that corrects errors arising during DNA replication (By similarity). Belongs to the DNA polymerase type-B family.


ensembl_gene_id: P30655
symbol: pts1
gene_biotype: protein_coding
description:
  Probable proteasome subunit beta type-5; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity; Belongs to the peptidase T1B family.


ensembl_gene_id: P30666
symbol: mcm3
gene_biotype: protein_coding
description:
  DNA replication licensing factor mcm3; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]


ensembl_gene_id: P30776
symbol: rad21
gene_biotype: protein_coding
description:
  Cohesin subunit rad21; Cleavable component of the cohesin complex, involved in chromosome cohesion during cell cycle. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At metaphase-anaphase transition, this protein is cleaved by cut1 and dissociates from chromatin, allowing sister chromatids to segregate. Also involved in the DNA double-strand-break (DSB) repair system.


ensembl_gene_id: P30821
symbol: obr1
gene_biotype: protein_coding
description:
  P25 protein; Unknown. Target of pap1 transcription factor. Confers brefeldin A resistance in S.pombe; Belongs to the WrbA family.


ensembl_gene_id: P31209
symbol: pabp
gene_biotype: protein_coding
description:
  Polyadenylate-binding protein, cytoplasmic and nuclear; Binds the poly(A) tail of mRNA. Appears to be an important mediator of the multiple roles of the poly(A) tail in mRNA biogenesis, stability and translation. In the nucleus, involved in both mRNA cleavage and polyadenylation. Is also required for efficient mRNA export to the cytoplasm. Acts in concert with a poly(A)-specific nuclease (PAN) to affect poly(A) tail shortening, which may occur concomitantly with either nucleocytoplasmic mRNA transport or translational initiation. In the cytoplasm, stimulates translation initiation and  [...]


ensembl_gene_id: P31317
symbol: arg3
gene_biotype: protein_coding
description:
  Ornithine carbamoyltransferase, mitochondrial; Ornithine carbamoyltransferase involved in the synthesis of arginine from glutamate via ornithine and the urea cycle.


ensembl_gene_id: P31318
symbol: arg11
gene_biotype: protein_coding
description:
  N-acetyl-gamma-glutamyl-phosphate reductase; In the C-terminal section; belongs to the NAGSA dehydrogenase family.


ensembl_gene_id: P31397
symbol: map3
gene_biotype: protein_coding
description:
  Pheromone M-factor receptor; Receptor for the peptide pheromone M-factor, a mating factor of S.pombe. Pheromone signaling is essential for initiation of meiosis in S.pombe; M-factor signaling alone may be sufficient.


ensembl_gene_id: P31406
symbol: vma1
gene_biotype: protein_coding
description:
  V-type proton ATPase catalytic subunit A; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.


ensembl_gene_id: P31411
symbol: vma2
gene_biotype: protein_coding
description:
  V-type proton ATPase subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells; Belongs to the ATPase alpha/beta chains family.


ensembl_gene_id: P32235
symbol: gtp1
gene_biotype: protein_coding
description:
  GTP-binding protein 1; Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.


ensembl_gene_id: P32372
symbol: rad4
gene_biotype: protein_coding
description:
  S-M checkpoint control protein rad4; Essential component for DNA replication and also the checkpoint control system which couples S and M phases. May directly or indirectly interact with chromatin proteins to form the complex required for the initiation and/or progression of DNA synthesis. Interacts simultaneously with both 'Thr-187' phosphorylation sites in a crb2 dimer for establishing the DNA checkpoint.


ensembl_gene_id: P32390
symbol: arp3
gene_biotype: protein_coding
description:
  Actin-related protein 3; Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (By similarity). May be involved in cytokinesis.


ensembl_gene_id: P32434
symbol: cwg2
gene_biotype: protein_coding
description:
  Geranylgeranyl transferase type-1 subunit beta; Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to proteins having the C-terminal C-A-A-L where A is an aliphatic amino acid. In particular it modifies the GTP- binding component of the 1,3-beta-D-glucan synthase.


ensembl_gene_id: P32586
symbol: pyp2
gene_biotype: protein_coding
description:
  Tyrosine-protein phosphatase 2; Plays a role in inhibiting the onset of mitosis. Dephosphorylates sty1/spc1 and wis1/spc2/sty2.


ensembl_gene_id: P32747
symbol: ura3
gene_biotype: protein_coding
description:
  Dihydroorotate dehydrogenase (quinone), mitochondrial; In the de novo pyrimidine biosynthesis pathway, catalyzes the stereospecific oxidation of (S)-dihydroorotate to orotate with reduction of flavin and the transfer of electrons to ubiquinone, which is part of the repiratory chain. Does not use fumarate and NAD as electron acceptors; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.


ensembl_gene_id: P32825
symbol: sxa2
gene_biotype: protein_coding
description:
  Carboxypeptidase sxa2; Involved in degradation or processing of the mating pheromones. Its loss causes a persistent response to the pheromones. It may be required for stabilization of enzymes that are essential for zygote formation. May degrade the mating pheromone P-factor.


ensembl_gene_id: P32834
symbol: sxa1
gene_biotype: protein_coding
description:
  Aspartic proteinase sxa1; Involved in degradation or processing of the mating pheromones. Its loss may cause a persistent response to the pheromones. It may cleave the mating pheromone M-factor. May be involved in processing of zymogens that are required for zygote formation.


ensembl_gene_id: P33075
symbol: adk1
gene_biotype: protein_coding
description:
  Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.


ensembl_gene_id: P33277
symbol: gap1
gene_biotype: protein_coding
description:
  GTPase-activating protein; Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase activity of Ras1.


ensembl_gene_id: P33520
symbol: res1
gene_biotype: protein_coding
description:
  Cell division cycle-related protein res1/sct1; Acts as a positive regulator of the mitotic cell cycle and as a negative regulator of sexual differentiation. May be involved in the transcriptional regulation of the cdc22 and cdt1 genes. Is an integral component of the DSC1-like complex.


ensembl_gene_id: P33532
symbol: bsu1
gene_biotype: protein_coding
description:
  Vitamin B6 transporter bsu1; Thiamine-regulated, high affinity import carrier of pyridoxine, pyridoxal and pyridoxamine. Also imports, but does not export, amiloride and so confers sensitivity. Belongs to the major facilitator superfamily. CAR1 family.


ensembl_gene_id: P33886
symbol: wis1
gene_biotype: protein_coding
description:
  Protein kinase wis1; Dosage-dependent regulator of mitosis with serine/ threonine protein kinase activity. May play a role in the integration of nutritional sensing with the control over entry into mitosis. It may interact with cdc25, wee1 and win1. May activate sty1.


ensembl_gene_id: P34068
symbol: mfm1
gene_biotype: protein_coding
description:
  M-factor; M-factor is a mating pheromone produced by M-type mating cells. All three mfm genes contribute to the production of M-factor.


ensembl_gene_id: P34208
symbol: chk1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase chk1; Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. Binds to and phosphorylates CDC25. This leads to negative regulation of CDC25 and prevents mitotic entry.


ensembl_gene_id: P35551
symbol: fib1
gene_biotype: protein_coding
description:
  rRNA 2'-O-methyltransferase fibrillarin; S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ105me), a modification [...]


ensembl_gene_id: P36579
symbol: arf1
gene_biotype: protein_coding
description:
  ADP-ribosylation factor 1; GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus; Belongs to the small GTPase superfamily. Arf family.


ensembl_gene_id: P36580
symbol: fba1
gene_biotype: protein_coding
description:
  Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.


ensembl_gene_id: P36581
symbol: cnx1
gene_biotype: protein_coding
description:
  Calnexin homolog; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins; Belongs to the calreticulin family.


ensembl_gene_id: P36582
symbol: pck1
gene_biotype: protein_coding
description:
  Protein kinase C-like 1; Involved in the control of the cell shape. Target of the inhibitor staurosporine; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.


ensembl_gene_id: P36583
symbol: pck2
gene_biotype: protein_coding
description:
  Protein kinase C-like 2; Involved in the control of the cell shape. Target of the inhibitor staurosporine; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.


ensembl_gene_id: P36586
symbol: ypt5
gene_biotype: protein_coding
description:
  GTP-binding protein ypt5; Protein transport. Probably involved in vesicular traffic (By similarity); Belongs to the small GTPase superfamily. Rab family.


ensembl_gene_id: P36587
symbol: ccr1
gene_biotype: protein_coding
description:
  NADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis. In the N-terminal section; belongs to the flavodoxin family.


ensembl_gene_id: P36589
symbol: cdc14
gene_biotype: protein_coding
description:
  Cell division control protein 14; Has a role in the septation initiation network (SIN) required for cytokinesis.


ensembl_gene_id: P36591
symbol: dfr1
gene_biotype: protein_coding
description:
  Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).


ensembl_gene_id: P36592
symbol: rad52
gene_biotype: protein_coding
description:
  DNA repair and recombination protein rad22; Active in the repair of DNA damage and in mating-type switching. Probably involved in the repair of DNA double-strands breaks. Has a role in promoting S phase completion; Belongs to the RAD52 family.


ensembl_gene_id: P36594
symbol: rpb1
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerase II subunit rpb1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cl [...]


ensembl_gene_id: P36595
symbol: rpb6
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerases I, II, and III subunit RPABC2; DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RPB6 is part of the clamp  [...]


ensembl_gene_id: P36596
symbol: erg9
gene_biotype: protein_coding
description:
  Squalene synthase; Catalyzes the condensation of 2 two farnesyl pyrophosphate moieties to form squalene. It is the first committed enzyme of the sterol biosynthesis pathway. Required for the biosynthesis of ergosterol; Belongs to the phytoene/squalene synthase family.


ensembl_gene_id: P36597
symbol: nmt1
gene_biotype: protein_coding
description:
  4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase; Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway. Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP). The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme.


ensembl_gene_id: P36598
symbol: thi1
gene_biotype: protein_coding
description:
  Thiamine repressible genes regulatory protein thi1; Transcription factor that activates the nmt1 promoter. Regulation of thiamine repressible genes. Positively regulates conjugation during meiosis.


ensembl_gene_id: P36601
symbol: rad51
gene_biotype: protein_coding
description:
  DNA repair protein rhp51; Required both for recombination and for the repair of DNA damage caused by X-rays. Binds to single and double-stranded DNA, in the presence of magnesium, and exhibits DNA-dependent ATPase activity. Promotes DNA strand annealing and strand exchange via DNA recombinase activity and forms helical nucleoprotein filaments. Belongs to the RecA family. RAD51 subfamily.


ensembl_gene_id: P36602
symbol: cdc22
gene_biotype: protein_coding
description:
  Ribonucleoside-diphosphate reductase large chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.


ensembl_gene_id: P36603
symbol: suc22
gene_biotype: protein_coding
description:
  Ribonucleoside-diphosphate reductase small chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family.


ensembl_gene_id: P36604
symbol: bip1
gene_biotype: protein_coding
description:
  Endoplasmic reticulum chaperone BiP; Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. Is required for secretory polypeptide translocation. May physically associate with SEC63 protein in the endoplasmic reticulum and this interaction may be regulated by ATP hydrolysis.


ensembl_gene_id: P36606
symbol: nhe1
gene_biotype: protein_coding
description:
  Na(+)/H(+) antiporter; Sodium export from cell, takes up external protons in exchange for internal sodium ions. Involved in regulation of pH; Belongs to the fungal Na(+)/H(+) exchanger family.


ensembl_gene_id: P36607
symbol: rad8
gene_biotype: protein_coding
description:
  DNA repair protein rad8; Probable helicase, member of the UBC2/RAD6 epistasis group. Functions with DNA repair protein rad18 in error-free postreplication DNA repair. Involved in the maintenance of wild-type rates of instability of simple repetitive sequences such as poly(GT) repeats (By similarity). Plays a role in surviving topoisomerase-mediated DNA damage.


ensembl_gene_id: P36611
symbol: php3
gene_biotype: protein_coding
description:
  Transcriptional activator hap3; Belongs to a complex that binds to the sequence CCAAT located upstream of genes involved in mitochondrial electron transport.


ensembl_gene_id: P36612
symbol: rpt2
gene_biotype: protein_coding
description:
  26S proteasome regulatory subunit 4 homolog; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.


ensembl_gene_id: P36613
symbol: mcs2
gene_biotype: protein_coding
description:
  Cyclin mcs2; Essential for progression through the cell cycle. Posseses kinase activity that can be detected when myelin basic protein (MBP) is provided as an exogenous substrate; Belongs to the cyclin family. Cyclin C subfamily.


ensembl_gene_id: P36614
symbol: ppe1
gene_biotype: protein_coding
description:
  Serine/threonine-protein phosphatase ppe1; Has a role in chromosome segregation. May provide a dynamic connection between kinetochore microtubules and kinetochore chromatin. Negatively regulates mis12.


ensembl_gene_id: P36615
symbol: csk1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase csk1; Acts as a CAK-activating kinase that specifically activates crk1 of the crk1-mcs2 CAK complex.


ensembl_gene_id: P36616
symbol: dsk1
gene_biotype: protein_coding
description:
  Protein kinase dsk1; May play an important role in mitotic control by altering cellular location, degree of phosphorylation and kinase activity. Abundant expression accelerates the exit when cells are in M-phase and also delays the entry into mitosis when cells are in G2. Phosphorylates prp2 in vitro and so may have a role in co-ordinating pre-mRNA splicing with the progression of the cell division cycle.


ensembl_gene_id: P36617
symbol: rad16
gene_biotype: protein_coding
description:
  DNA repair protein rad16; Endonuclease that specifically degrades single-stranded DNA and which is involved in nucleotide excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents. Required for double strand break-induced interchromosomal gene conversion. Belongs to the XPF family.


ensembl_gene_id: P36618
symbol: cdc16
gene_biotype: protein_coding
description:
  Cell division control protein 16; Has a dual role in the cell cycle. In mitosis, it is involved in maintenance of cdc2 kinase activity. It is subsequently required for regulation of septum formation. Could be involved in maintenance of cdc2 kinase activity by preventing, directly or indirectly, the degradation of cyclin or the dephosphorylation of 'Thr-167' of cdc2.


ensembl_gene_id: P36619
symbol: pmd1
gene_biotype: protein_coding
description:
  Leptomycin B resistance protein pmd1; May be a transmembrane transporter of the mating factor, namely P-factor or M-factor. Confers resistance to leptomycin B and to several other antifungal drugs; Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.


ensembl_gene_id: P36621
symbol: cap1
gene_biotype: protein_coding
description:
  Adenylyl cyclase-associated protein; The N-terminal domain binds to adenylyl cyclase, thereby enabling adenylyl cyclase to be activated by upstream regulatory signals, such as Ras. The C-terminal domain is required for normal cellular morphology and growth control.


ensembl_gene_id: P36623
symbol: gpm1
gene_biotype: protein_coding
description:
  Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily.


ensembl_gene_id: P36624
symbol: tms1
gene_biotype: protein_coding
description:
  Sorbitol dehydrogenase; Polyol dehydrogenase that catalyzes the reversible NAD(+)- dependent oxidation of various sugar alcohols. Is active with D- sorbitol (D-glucitol) as substrate, leading to the C2-oxidized product D-fructose (By similarity). Suppresses growth arrest induced by a p53 tumor mutant in fission yeast.


ensembl_gene_id: P36625
symbol: rec7
gene_biotype: protein_coding
description:
  Meiotic recombination protein rec7; May be involved primarily in the early steps of meiotic recombination.


ensembl_gene_id: P36626
symbol: rec8
gene_biotype: protein_coding
description:
  Meiotic recombination protein rec8; Involved primarily in the early steps of meiotic recombination. Required to ensure reductional chromosome segregation. Belongs to the rad21 family.


ensembl_gene_id: P36627
symbol: byr3
gene_biotype: protein_coding
description:
  Cellular nucleic acid-binding protein homolog; Acts in the sexual differentiation pathway. Is required for efficient conjugation. Double-stranded DNA-binding protein.


ensembl_gene_id: P36629
symbol: prp2
gene_biotype: protein_coding
description:
  Splicing factor U2AF 59 kDa subunit; Necessary for the splicing of pre-mRNA. The SF1-U2AF59-U2AF23 complex has a role in the recognition of the branch site (5'-UACUAAC- 3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns; Belongs to the splicing factor SR family.


ensembl_gene_id: P36630
symbol: cig2
gene_biotype: protein_coding
description:
  G2/mitotic-specific cyclin cig2; Essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transition. Interacts with the cdc2 protein kinase to form MPF. Interaction with res2 promotes the phosphorylation of res1 and inhibits MBF-dependent gene transcription. Forms an autoregulating feedback-inhibition loop with MBF which is important for normal regulation of the cell cycle. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis. Negatively regulates conjugation via interacting with cell cycle 'start' genes. Degraded by skp1, pop1 and pop2 in [...]


ensembl_gene_id: P36631
symbol: ste11
gene_biotype: protein_coding
description:
  Transcription factor ste11; Key transcription factor for sexual development. Activates the transcription of the matp, matm, mei2, mfm, ste6 and rgs1 genes. Binds specifically to a DNA fragment carrying a 10-base motif 5'- TTCTTTGTTY-3'.


ensembl_gene_id: P36632
symbol: rad26
gene_biotype: protein_coding
description:
  DNA repair protein rad26; Involved in cell cycle arrest when DNA synthesis is inhibited by hydroxyurea, and in mitosis arrest after treatment with DNA-damaging agents. This protein is S phase-specific.


ensembl_gene_id: P37202
symbol: dis3
gene_biotype: protein_coding
description:
  Exosome complex exonuclease dis3; Catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm.  [...]


ensembl_gene_id: P37382
symbol: rpb3
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerase II subunit RPB3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB3 is part of the core element with the central large cleft and the clamp element that moves to open and close the cleft (By similarity).


ensembl_gene_id: P38937
symbol: cut8
gene_biotype: protein_coding
description:
  Tethering factor for nuclear proteasome cut8; Involved in ubiquitin-mediated protein degradation. Regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates. Targets proteasomes to the nucleus and facilitates the degradation of nuclear proteins like mitotic cyclin and cut2. Required for normal progression of anaphase.


ensembl_gene_id: P38938
symbol: cek1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase cek1; May facilitate the progression of anaphase through direct or indirect interaction with the cut8 protein.


ensembl_gene_id: P39750
symbol: rad2
gene_biotype: protein_coding
description:
  Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as  [...]


ensembl_gene_id: P39825
symbol: cdc3
gene_biotype: protein_coding
description:
  Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. In S.pombe, it is essential for cytokinesis.


ensembl_gene_id: P39964
symbol: cdc5
gene_biotype: protein_coding
description:
  Pre-mRNA-splicing factor cdc5; Involved in mRNA splicing and cell cycle control. Belongs to the CEF1 family.


ensembl_gene_id: P40231
symbol: cka1
gene_biotype: protein_coding
description:
  Casein kinase II subunit alpha; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Plays a role in the translation of cell polarity into polarized growth. The alpha and alpha' chains contain the catalytic site.


ensembl_gene_id: P40232
symbol: ckb1
gene_biotype: protein_coding
description:
  Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit.


ensembl_gene_id: P40233
symbol: cki1
gene_biotype: protein_coding
description:
  Casein kinase I homolog 1; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates.


ensembl_gene_id: P40234
symbol: cki2
gene_biotype: protein_coding
description:
  Casein kinase I homolog 2; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. May contribute to the regulation of morphology.


ensembl_gene_id: P40235
symbol: hhp1
gene_biotype: protein_coding
description:
  Casein kinase I homolog hhp1; Involved in DNA repair. Has a probable role in repairing alkylated DNA and may regulate the activity of protein(s) involved in double strand break repair caused by gamma rays; Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.


ensembl_gene_id: P40236
symbol: hhp2
gene_biotype: protein_coding
description:
  Casein kinase I homolog hhp2; Involved in DNA repair. May regulate the activity of protein(s) involved in double strand break repair caused by gamma rays; Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.


ensembl_gene_id: P40371
symbol: ptc1
gene_biotype: protein_coding
description:
  Protein phosphatase 2C homolog 1; It has a serine and threonine phosphatase activity. Has a specialized role in the heat shock response. May be responsible for the dephosphorylation of hsp90. Also has a role in maintaining osmotic stability.


ensembl_gene_id: P40373
symbol: his1
gene_biotype: protein_coding
description:
  ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity).


ensembl_gene_id: P40374
symbol: his5
gene_biotype: protein_coding
description:
  Imidazoleglycerol-phosphate dehydratase; Belongs to the imidazoleglycerol-phosphate dehydratase family.


ensembl_gene_id: P40377
symbol: mcm2
gene_biotype: protein_coding
description:
  DNA replication licensing factor mcm2; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]


ensembl_gene_id: P40379
symbol: rep1
gene_biotype: protein_coding
description:
  Transcriptional activator protein rec16; Transcriptional activator that controls the onset of premeiotic DNA synthesis by regulating res2 and some other factor(s) in a mei2 independent cascade.


ensembl_gene_id: P40380
symbol: rum1
gene_biotype: protein_coding
description:
  Cyclin-dependent kinase inhibitor rum1; Regulator of cell cycle G1 phase progression. Ensures the correct sequence of S phase and mitosis in the cell by acting as an inhibitor of the cdc2 mitotic kinase. Probably interacts with cdc2 to inhibit its action until the cell mass for Start is reached. Determines the length of the pre-Start G1 period and prevents mitosis from happening in early G1 cells. Required for maintaining pheromone-induced G1 arrest. Acts as an adapter protein since interaction with cdc13 promotes cyclin proteolysis during G1. Becomes a target for degradation at the G1 [...]


ensembl_gene_id: P40381
symbol: swi6
gene_biotype: protein_coding
description:
  Chromatin-associated protein swi6; Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Involved in the repression of the silent mating-type loci MAT2 and MAT3. May compact MAT2/3 into a heterochromatin-like conformation which represses the transcription of these silent cassettes.


ensembl_gene_id: P40382
symbol: cdt1
gene_biotype: protein_coding
description:
  Cell division cycle protein cdt1; DNA replication licensing factor, required for pre- replication complex assembly. Faithful duplication of the genetic material requires 'once per cell cycle' DNA replication initiation and elongation. Central to this control is the tightly regulated formation of prereplicative complexes (preRCs) at future origins of DNA replication. Required for the recruitment of the MCM helicase complex to the replication origins; Belongs to the Cdt1 family.


ensembl_gene_id: P40383
symbol: exo2
gene_biotype: protein_coding
description:
  5'-3' exoribonuclease 1; Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins. Involved in the degradation of several hypomodified mature tRNA species and participates in the 5'-processing or the degradation of the snoRNA pr [...]


ensembl_gene_id: P40384
symbol: rec12
gene_biotype: protein_coding
description:
  Meiotic recombination protein rec12; Required for formation of the double-strand breaks (DSBs) that initiate meiotic recombination. Required for crossover recombination and chiasmatic segregation of chromosomes during meiosis I. Also involved in the faithful equational segregation of chromosomes during meiosis II.


ensembl_gene_id: P40385
symbol: rec6
gene_biotype: protein_coding
description:
  Meiotic recombination protein rec6; Required for formation of the rec12-mediated double-strand breaks (DSBs) that initiate meiotic recombination. May be involved primarily in the early steps of meiotic recombination (Probable); Belongs to the TOP6B-like family.


ensembl_gene_id: P40386
symbol: thi4
gene_biotype: protein_coding
description:
  Probable thiamine biosynthetic bifunctional enzyme; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). In the C-terminal section; belongs to the Thz kinase family.


ensembl_gene_id: P40387
symbol: tps1
gene_biotype: protein_coding
description:
  Alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Appears to have a role in spore germination. In S.pombe it appears to have no role in the control of the initial steps of glycolysis.


ensembl_gene_id: P40388
symbol: uvi15
gene_biotype: protein_coding
description:
  UV-induced protein uvi15; Required for the maintenance of viability of cells in stationary phase and in starvation conditions.


ensembl_gene_id: P40389
symbol: efm2
gene_biotype: protein_coding
description:
  Protein-lysine N-methyltransferase rrg1; S-adenosyl-L-methionine-dependent protein-lysine N- methyltransferase that methylates elongation factor 2 and elongation factor 3A.


ensembl_gene_id: P40847
symbol: sap1
gene_biotype: protein_coding
description:
  Switch-activating protein 1; Binds to sequences required for mating-type switching. Makes a simultaneous contact with both the alpha and beta domains of the switch-activating site SAS1. Also binds to replication fork barrier 1 (RFB1) located within a 78 base pair sequence near the 3' end of the rRNA coding region. This leads to replication fork blockage. It binds the consensus sequence 5'-TA[AG]GCAGNTN[CT]AACG[AC]G-3'.


ensembl_gene_id: P40848
symbol: dhp1
gene_biotype: protein_coding
description:
  5'-3' exoribonuclease 2; Required for the processing of nuclear mRNA and rRNA precursors. May promote the termination of transcription by RNA polymerase II (By similarity). Essential for vegetative cell growth and chromosome segregation. Possesses 5'->3' exoribonuclease activity.


ensembl_gene_id: P40901
symbol: isp5
gene_biotype: protein_coding
description:
  Sexual differentiation process putative amino-acid permease isp5; Belongs to the amino acid-polyamine-organocation (APC) superfamily.


ensembl_gene_id: P40921
symbol: SPAC29A4.02c
gene_biotype: protein_coding
description:
  Elongation factor 1-gamma; Probably plays a role in anchoring the complex to other cellular components.


ensembl_gene_id: P40923
symbol: yox1
gene_biotype: protein_coding
description:
  MBF complex negative regulatory component yox1; Negative regulatory component of the MBF transcription factor complex involved in cell-cycle G1/S phase-specific gene expression and more particularly DNA replication checkpoint-dependent gene expression.


ensembl_gene_id: P40976
symbol: lys1
gene_biotype: protein_coding
description:
  L-2-aminoadipate reductase; Catalyzes the activation of alpha-aminoadipate by ATP- dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH. The activated alpha-aminoadipate is bound to the phosphopantheinyl group of the enzyme itself before it is reduced to (S)-2-amino-6-oxohexanoate.


ensembl_gene_id: P40977
symbol: plc1
gene_biotype: protein_coding
description:
  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.


ensembl_gene_id: P40984
symbol: hus5
gene_biotype: protein_coding
description:
  SUMO-conjugating enzyme ubc9; Catalyzes the covalent attachment of ubiquitin-like protein SUMO/Smt3 to other proteins. Required for efficient recovery from DNA damage or S-phase arrest and normal mitosis. This may be as part of a checkpoint independent recovery process; Belongs to the ubiquitin-conjugating enzyme family.


ensembl_gene_id: P40995
symbol: scd1
gene_biotype: protein_coding
description:
  Rho guanine nucleotide exchange factor scd1; Required for mating and morphogenesis. May contain a cryptic binding site for cdc42 that is enhanced by binding Ras. Interacts directly with scd2. Promotes the exchange of cdc42-bound GDP by GTP. Involved in septation and stimulates the elongation of conjugation tubes.


ensembl_gene_id: P40996
symbol: scd2
gene_biotype: protein_coding
description:
  Protein scd2/ral3; Required for mating and morphogenesis. Interacts directly with scd1 and with cdc42. May bridge and facilitate scd1 and cdc42 interactions.


ensembl_gene_id: P40997
symbol: ceg1
gene_biotype: protein_coding
description:
  mRNA-capping enzyme subunit alpha; Second step of mRNA capping. Transfer of the GMP moiety of GTP to the 5'-end of RNA via an enzyme-GMP covalent reaction intermediate (By similarity); Belongs to the eukaryotic GTase family.


ensembl_gene_id: P40998
symbol: thi2
gene_biotype: protein_coding
description:
  Thiamine thiazole synthase; Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5- (2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron- dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance.


ensembl_gene_id: P40999
symbol: pmt1
gene_biotype: protein_coding
description:
  tRNA (cytosine(38)-C(5))-methyltransferase; Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp). Can also methylate cytosine 38 in tRNA(Glu), albeit to a lower level, but not tRNA(Lys). Pmt1-dependent tRNA methylation is induced by nitrogen limitation and depends on the nutrient-sensing protein kinase sck2. Does not have DNA-methylation activity. Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.


ensembl_gene_id: P41000
symbol: cps3
gene_biotype: protein_coding
description:
  Protein cps3; Responsible for supersensitivity to the spindle poison, isopropyl N-3-chlorophenyl carbamate. Has a role in meiosis.


ensembl_gene_id: P41003
symbol: cut14
gene_biotype: protein_coding
description:
  Structural maintenance of chromosomes protein 2; Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.


ensembl_gene_id: P41004
symbol: cut3
gene_biotype: protein_coding
description:
  Structural maintenance of chromosomes protein 4; Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases; Belongs to the SMC family. SMC4 subfamily.


ensembl_gene_id: P41005
symbol: mes1
gene_biotype: protein_coding
description:
  Protein mes1; Specifically required for meiosis II (MII). Binds to slp1, an activator of the anapahase promoting complex/cyclcosome (APC/C), and counteracts its function in promoting proteolysis of cdc13. By suppressing the degradation of cdc13 at anaphase I this protein may help maintain a sufficient level of cdc2 kinase activity to complete MII.


ensembl_gene_id: P41389
symbol: mcm5
gene_biotype: protein_coding
description:
  DNA replication licensing factor mcm5; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]


ensembl_gene_id: P41391
symbol: rna1
gene_biotype: protein_coding
description:
  Ran GTPase-activating protein 1; GTPase activator for the nuclear Ras-related regulatory protein spi1 (Ran), converting it to the putatively inactive GDP-bound state.


ensembl_gene_id: P41410
symbol: rad54
gene_biotype: protein_coding
description:
  DNA repair protein rhp54; Involved in DNA repair. May have a role in the processing of replication structures during late replication that is different from its role in the repair of radiation damage; Belongs to the SNF2/RAD54 helicase family.


ensembl_gene_id: P41411
symbol: cdc18
gene_biotype: protein_coding
description:
  Cell division control protein 18; Part of the checkpoint control that prevents mitosis from occurring until S phase is completed. Plays a key role in coupling S phase to start and mitosis. Acts at the initiation of DNA replication and plays a major role in controlling the onset of S-phase. Together with orp1, involved in the maintenance of replication forks and activation of cds1-dependent S-phase checkpoint. Belongs to the CDC6/cdc18 family.


ensembl_gene_id: P41412
symbol: res2
gene_biotype: protein_coding
description:
  Cell division cycle-related protein res2/pct1; Required for the initiation of mitotic and premeiotic DNA synthesis. Has an additional role in meiotic division.


ensembl_gene_id: P41820
symbol: bfr1
gene_biotype: protein_coding
description:
  Brefeldin A resistance protein; Confers hyper-resistance to brefeldin A (BFA), an inhibitor of intracellular protein transport. Could serve as an efflux pump of various antibiotics; Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.


ensembl_gene_id: P41831
symbol: SPAC4A8.14
gene_biotype: protein_coding
description:
  Ribose-phosphate pyrophosphokinase 1; 5-phosphoribose 1-diphosphate synthase involved in nucleotide, histidine, and tryptophan biosynthesis. Active in heteromultimeric complexes with other 5-phosphoribose 1-diphosphate synthases (By similarity); Belongs to the ribose-phosphate pyrophosphokinase family.


ensembl_gene_id: P41836
symbol: rpt6
gene_biotype: protein_coding
description:
  26S proteasome regulatory subunit 8 homolog; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).


ensembl_gene_id: P41838
symbol: rae1
gene_biotype: protein_coding
description:
  Poly(A)+ RNA export protein; Required for mitotic cell growth as well as for spore germination. Functions in cell cycle progression through trafficking of proteins required for mitosis. Has a role in the mRNA export process.


ensembl_gene_id: P41878
symbol: rpn11
gene_biotype: protein_coding
description:
  26S proteasome regulatory subunit rpn11; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.


ensembl_gene_id: P41887
symbol: hsp90
gene_biotype: protein_coding
description:
  Heat shock protein 90 homolog; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (By similarity). Interacts with the wee1 protein kinase; which re [...]


ensembl_gene_id: P41888
symbol: tnr3
gene_biotype: protein_coding
description:
  Thiamine pyrophosphokinase; Involved in the regulation of thiamine metabolism, phosphate metabolism, mating and cell growth.


ensembl_gene_id: P41889
symbol: cut9
gene_biotype: protein_coding
description:
  Anaphase-promoting complex subunit cut9; Component of the anaphase-promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. May play a pivotal role in the control of anaphase.


ensembl_gene_id: P41891
symbol: gar2
gene_biotype: protein_coding
description:
  Protein gar2; Helps the assembly of pre-ribosomal particles containing 18S rRNA; Belongs to the RRM GAR family.


ensembl_gene_id: P41892
symbol: cdc7
gene_biotype: protein_coding
description:
  Cell division control protein 7; Protein kinase essential for cell division. Plays a key role in initiation of septum formation and cytokinesis.


ensembl_gene_id: P41893
symbol: stp1
gene_biotype: protein_coding
description:
  Low molecular weight phosphotyrosine protein phosphatase; May contribute to dephosphorylation of 'Tyr-15' of cdc2; Belongs to the low molecular weight phosphotyrosine protein phosphatase family.


ensembl_gene_id: P42656
symbol: rad24
gene_biotype: protein_coding
description:
  DNA damage checkpoint protein rad24; Required for the DNA damage checkpoint that ensures that DNA damage is repaired before mitosis is attempted. Acts as a negative regulator of meiosis by antagonizing the function of mei2. It inhibits the association of meiRNA (a non-coding RNA molecule required for the nuclear mei2 dot formation) to the phosphorylated but not to the unphosphorylated form of mei2 in vitro.


ensembl_gene_id: P42657
symbol: rad25
gene_biotype: protein_coding
description:
  DNA damage checkpoint protein rad25; Required for the DNA damage checkpoint that ensures that DNA damage is repaired before mitosis is attempted.


ensembl_gene_id: P42881
symbol: gpt2
gene_biotype: protein_coding
description:
  UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase; Catalyzes the initial step in the synthesis of dolichol-P-P- oligosaccharides; Belongs to the glycosyltransferase 4 family.


ensembl_gene_id: P46595
symbol: ubc4
gene_biotype: protein_coding
description:
  Ubiquitin-conjugating enzyme E2 4; Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. Mediates ubiquitination of PEX5.


ensembl_gene_id: P46960
symbol: ptb1
gene_biotype: protein_coding
description:
  Geranylgeranyl transferase type-2 subunit beta; Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to proteins having the C-terminal -XCC or -XCXC, where both cysteines may become modified; Belongs to the protein prenyltransferase subunit beta family.


ensembl_gene_id: P47943
symbol: tif1
gene_biotype: protein_coding
description:
  ATP-dependent RNA helicase eIF4A; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity).


ensembl_gene_id: P47946
symbol: trk1
gene_biotype: protein_coding
description:
  Potassium transport protein 1; Together with TRK2, defines the major, high-affinity potassium influx transport system. Involved in maintenance of the proper sodium/potassium ratio in the cell and in regulating the plasma membrane potential.


ensembl_gene_id: P47979
symbol: zfs1
gene_biotype: protein_coding
description:
  Zinc finger protein zfs1; Binds to specific AU-rich elements (ARE) in the 3'- untranslated region of target mRNAs and promotes their degradation. Binds to ARE present in the arz1 mRNA and stimulates the rate of arz1 mRNA decay. Required for coordination of septum formation with exit from mitosis. Involved in the mating response pathway. Induces sexual development and ascus formation.


ensembl_gene_id: P48003
symbol: pht1
gene_biotype: protein_coding
description:
  Histone H2A.Z; Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Important for chromosomal structure and function, possibly including a role in controlling the fidelity o [...]


ensembl_gene_id: P48008
symbol: spn3
gene_biotype: protein_coding
description:
  Septin homolog spn3; Plays a role in the cell cycle. Involved in a late stage of septum formation leading to the separation of the daughter cells.


ensembl_gene_id: P48009
symbol: spn4
gene_biotype: protein_coding
description:
  Septin homolog spn4; Plays a role in the cell cycle. Involved in a late stage of septum formation leading to the separation of the daughter cells.


ensembl_gene_id: P48010
symbol: spn5
gene_biotype: protein_coding
description:
  Septin homolog spn5; Septin-like protein involved in the correct orientation of forespore membrane extension during sporulation. Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.


ensembl_gene_id: P48011
symbol: rpc10
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerases I, II, and III subunit RPABC4; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively.


ensembl_gene_id: P48383
symbol: sak1
gene_biotype: protein_coding
description:
  Protein sak1; Positively regulates cyclic AMP-dependent protein kinase- mediated exit from the mitotic cell cycle; Belongs to the RFX family.


ensembl_gene_id: P49373
symbol: tfs1
gene_biotype: protein_coding
description:
  Transcription elongation factor S-II; Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus (By similarity). Belongs to the TFS-II family.


ensembl_gene_id: P49731
symbol: mcm6
gene_biotype: protein_coding
description:
  DNA replication licensing factor mcm6; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]


ensembl_gene_id: P49740
symbol: ndk1
gene_biotype: protein_coding
description:
  Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.


ensembl_gene_id: P49776
symbol: aph1
gene_biotype: protein_coding
description:
  Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]; Asymmetrically hydrolyzes Ap4A to yield AMP and ATP.


ensembl_gene_id: P49777
symbol: cbp1
gene_biotype: protein_coding
description:
  ARS-binding protein 1; Binds, preferentially, to the Maundrell ARS consensus sequence within ARS3002.


ensembl_gene_id: P50515
symbol: vma3
gene_biotype: protein_coding
description:
  V-type proton ATPase 16 kDa proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.


ensembl_gene_id: P50520
symbol: pik3
gene_biotype: protein_coding
description:
  Phosphatidylinositol 3-kinase vps34; Phosphatidylinositol 3-kinase homolog required for vacuolar sorting and segregation; Belongs to the PI3/PI4-kinase family.


ensembl_gene_id: P50521
symbol: hxk2
gene_biotype: protein_coding
description:
  Hexokinase-2; Catalyzes the phosphorylation of hexose (six-carbon sugars) to hexose 6-phosphate. Phosphorylates D-glucose, D-fructose and D-mannose. Compared to hxk1, has a much higher affinity for D-glucose. Constitutes the initial enzyme of glycolysis by catalyzing the phosphorylation of glucose to D-glucose 6- phosphate (Probable).


ensembl_gene_id: P50523
symbol: qcr8
gene_biotype: protein_coding
description:
  Cytochrome b-c1 complex subunit 8; Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inn [...]


ensembl_gene_id: P50524
symbol: rpn12
gene_biotype: protein_coding
description:
  26S proteasome regulatory subunit rpn12; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.


ensembl_gene_id: P50525
symbol: apn1
gene_biotype: protein_coding
description:
  DNA-(apurinic or apyrimidinic site) lyase 1; DNA repair enzyme that cleaves apurinic/apyrimidinic (AP) sites and removes 3'-blocking groups present at single strand breaks of damaged DNA. Provides back-up AP endonuclease (APE) activity to apn2 together with uve1.


ensembl_gene_id: P50526
symbol: ssp1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase ssp1; Involved in actin localization and thus in polarized cell growth; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.


ensembl_gene_id: P50527
symbol: shk1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase shk1/pak1; MAP4K component of the MAPK pathway required for the mating pheromone response. Phosphorylates histone H2B to form H2BS10ph (By similarity). Phosphorylates tea1. Required for skb1-dependent mitotic inhibitory function. Regulates microtubule dynamics and cell polarity. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.


ensembl_gene_id: P50528
symbol: plo1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase plo1; Required to form a bipolar spindle, the actin ring and septum. Functions upstream of the whole septum formation pathway, including actin ring formation (regulated by late septation genes) and septal material deposition (regulated by early septation genes). Behaves as a 'septum-promoting factor', and could also be involved in inducing other late events of cell division. Together with moa1, acts as a regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromer [...]


ensembl_gene_id: P50530
symbol: sck1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase sck1; Protein kinase that is part of growth control pathway which is at least partially redundant with the cAMP pathway. Required for trehalase activation.


ensembl_gene_id: P50531
symbol: rad17
gene_biotype: protein_coding
description:
  Checkpoint protein rad17; Participates in checkpoint pathways arrest of the cell cycle. A mechanism that allows the DNA repair pathways to act to restore the integrity of the DNA prior to DNA synthesis or separation of the replicated chromosomes.


ensembl_gene_id: P50537
symbol: mae1
gene_biotype: protein_coding
description:
  Malic acid transport protein; Permease for malate and other C4 dicarboxylic acids; Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.


ensembl_gene_id: P50582
symbol: hsk1
gene_biotype: protein_coding
description:
  Cell cycle serine/threonine-protein kinase hsk1; Required for G1/S transition. Plays a role in DNA replication checkpoint signaling through regulating rad3 and cds1. Involved in the maintenance of mitotic chromosome structures during S phase through regulating the function of rad21. Required for initiation of mitotic DNA replication through phosphorylating mcm2/cdc19. Required for genome integrity; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC7 subfamily.


ensembl_gene_id: P50998
symbol: ada1
gene_biotype: protein_coding
description:
  AMP deaminase; AMP deaminase plays a critical role in energy metabolism; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.


ensembl_gene_id: P50999
symbol: cct4
gene_biotype: protein_coding
description:
  T-complex protein 1 subunit delta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity).


ensembl_gene_id: P52822
symbol: rpl501
gene_biotype: protein_coding
description:
  60S ribosomal protein L5-A; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome throug [...]


ensembl_gene_id: P52890
symbol: atf1
gene_biotype: protein_coding
description:
  Transcription factor atf1; Transcription factor required for sexual development and entry into stationary phase. Binds and activates meiotic recombination hot spot ade6-M26.


ensembl_gene_id: P53692
symbol: smc6
gene_biotype: protein_coding
description:
  Structural maintenance of chromosomes protein 6; Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks. Plays a critical role in meiosis. Belongs to the SMC family. SMC6 subfamily.


ensembl_gene_id: P53694
symbol: rtn1
gene_biotype: protein_coding
description:
  Reticulon-like protein 1; Required for the correct positioning of the cellular division plane by delimiting the actomyosin ring assembly at the cell equator. Overexpression causes cell lysis.


ensembl_gene_id: P53695
symbol: exo1
gene_biotype: protein_coding
description:
  Exodeoxyribonuclease 1; 5'->3' double-stranded DNA exonuclease that could act in a pathway that corrects mismatched base pairs.


ensembl_gene_id: P54789
symbol: orc1
gene_biotype: protein_coding
description:
  Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. ORC binds to multiple sites within the ars1 origin of DNA replication in an ATP-independent manner; Belongs to the ORC1 family.


ensembl_gene_id: P54874
symbol: hcs1
gene_biotype: protein_coding
description:
  Hydroxymethylglutaryl-CoA synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.


ensembl_gene_id: P55306
symbol: ctt1
gene_biotype: protein_coding
description:
  Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.


ensembl_gene_id: P55877
symbol: tif11
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 1A; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits (By similarity).


ensembl_gene_id: P56286
symbol: tif211
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 2 subunit alpha; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction cat [...]


ensembl_gene_id: P56287
symbol: tif225
gene_biotype: protein_coding
description:
  Probable translation initiation factor eIF-2B subunit epsilon; Subunit of the guanine nucleotide exchange factor for eIF-2. Belongs to the eIF-2B gamma/epsilon subunits family.


ensembl_gene_id: P56288
symbol: tif223
gene_biotype: protein_coding
description:
  Probable translation initiation factor eIF-2B subunit gamma; Catalyzes the exchange of eukaryotic initiation factor 2- bound GDP for GTP.


ensembl_gene_id: P56289
symbol: tif51
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 5A-1; mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis (By similarity); Belongs to the eIF-5A family.


ensembl_gene_id: P56329
symbol: tif212
gene_biotype: protein_coding
description:
  Probable eukaryotic translation initiation factor 2 subunit beta; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reac [...]


ensembl_gene_id: P56523
symbol: clr3
gene_biotype: protein_coding
description:
  Histone deacetylase clr3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Required for proper positioning of nucleosomes at heterochromatic loci and for transcriptional gene silencing (TGS) function of the Snf2/Hdac-containing repressor complex (SHREC).


ensembl_gene_id: P62505
symbol: dad3
gene_biotype: protein_coding
description:
  DASH complex subunit dad3; Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity).


ensembl_gene_id: P62506
symbol: mrpl44
gene_biotype: protein_coding
description:
  54S ribosomal protein L44, mitochondrial; Involved in mitochondrial genome encoded proteins translation.


ensembl_gene_id: P78750
symbol: utp18
gene_biotype: protein_coding
description:
  Probable U3 small nucleolar RNA-associated protein 18; Involved in nucleolar processing of pre-18S ribosomal RNA.


ensembl_gene_id: P78759
symbol: par2
gene_biotype: protein_coding
description:
  Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta 2 isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Has a role in cell shape control and septum formation.


ensembl_gene_id: P78761
symbol: qcr2
gene_biotype: protein_coding
description:
  Cytochrome b-c1 complex subunit 2, mitochondrial; Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradie [...]


ensembl_gene_id: P78768
symbol: vti1
gene_biotype: protein_coding
description:
  Vesicle transport v-SNARE protein vti1; V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers (By similarity); Belongs to the VTI1 family.


ensembl_gene_id: P78774
symbol: arc1
gene_biotype: protein_coding
description:
  Actin-related protein 2/3 complex subunit 1; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.


ensembl_gene_id: P78780
symbol: SPCC1827.06c
gene_biotype: protein_coding
description:
  Probable aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family.


ensembl_gene_id: P78789
symbol: amk2
gene_biotype: protein_coding
description:
  5'-AMP-activated protein kinase subunit beta; Beta subunit of AMP-activated protein kinase (AMPK), which is required for transcriptional, metabolic, and developmental adaptations in response to glucose limitation. Has a structural role, mediating heterotrimer formation, and a regulatory role, defining carbon source- regulated subcellular location and substrate specificity of the AMPK kinase complex.


ensembl_gene_id: P78790
symbol: etf1
gene_biotype: protein_coding
description:
  Probable electron transfer flavoprotein subunit alpha, mitochondrial; The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF- ubiquinone oxidoreductase (ETF dehydrogenase) (By similarity).


ensembl_gene_id: P78795
symbol: tif307
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 3 subunit G; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA.


ensembl_gene_id: P78798
symbol: pex7
gene_biotype: protein_coding
description:
  Peroxisomal targeting signal 2 receptor; Binds to the N-terminal PTS2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import.


ensembl_gene_id: P78810
symbol: vtc4
gene_biotype: protein_coding
description:
  Vacuolar transporter chaperone 4; Component of the vacuolar transporter chaperone (VTC) complex, which plays a role in vacuolar membrane fusion.


ensembl_gene_id: P78811
symbol: fyu1
gene_biotype: protein_coding
description:
  Probable UTP--glucose-1-phosphate uridylyltransferase; Plays a central role as a glucosyl donor in cellular metabolic pathways; Belongs to the UDPGP type 1 family.


ensembl_gene_id: P78812
symbol: gnd1
gene_biotype: protein_coding
description:
  6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.


ensembl_gene_id: P78814
symbol: srp2
gene_biotype: protein_coding
description:
  Pre-mRNA-splicing factor srp2; Has a role in pre-mRNA splicing where it is involved in spliceosome assembly.


ensembl_gene_id: P78820
symbol: cut6
gene_biotype: protein_coding
description:
  Acetyl-CoA carboxylase; Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.


ensembl_gene_id: P78827
symbol: ilv5
gene_biotype: protein_coding
description:
  Probable ketol-acid reductoisomerase, mitochondrial; Belongs to the ketol-acid reductoisomerase family.


ensembl_gene_id: P78831
symbol: ght5
gene_biotype: protein_coding
description:
  High-affinity glucose transporter ght5; High-affinity glucose transporter; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.


ensembl_gene_id: P78847
symbol: nup186
gene_biotype: protein_coding
description:
  Nucleoporin nup186; Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope; Belongs to the NUP186/NUP192/NUP205 family.


ensembl_gene_id: P78854
symbol: plb1
gene_biotype: protein_coding
description:
  Lysophospholipase 1; Catalyzes the release of fatty acids from lysophospholipids. Required for survival under high osmolarity, for normal osmotic stress- induced gene expression, and for nutrient-mediated repression of sexual differentiation.


ensembl_gene_id: P78859
symbol: isa1
gene_biotype: protein_coding
description:
  Iron-sulfur assembly protein 1; Involved in the assembly of mitochondrial and cytoplasmic iron-sulfur proteins. Probably involved in the binding of an intermediate of Fe/S cluster assembly; Belongs to the HesB/IscA family.


ensembl_gene_id: P78860
symbol: mrm2
gene_biotype: protein_coding
description:
  rRNA methyltransferase 2, mitochondrial; S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of the 2'-O- methyluridine corresponding to position 2791 in S.cerevisiae 21S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA.


ensembl_gene_id: P78871
symbol: rst2
gene_biotype: protein_coding
description:
  Zinc finger protein rst2; Key transcription factor for sexual development. Activates the transcription of ste11. Binds to a stress response element-like (SRE) region in the ste11 promoter.


ensembl_gene_id: P78921
symbol: cct8
gene_biotype: protein_coding
description:
  Probable T-complex protein 1 subunit theta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity).


ensembl_gene_id: P78926
symbol: map1
gene_biotype: protein_coding
description:
  Pheromone receptor transcription activator; In response to mating-pheromone signaling or nitrogen starvation, it interacts with mat1-Pc. This activates the expression of one of two mating-type-specific genes sxa2 or map3, which leads to inactivation of the P-factor. May also interact with mat1-Mc.


ensembl_gene_id: P78929
symbol: adf1
gene_biotype: protein_coding
description:
  Cofilin; Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. Binding to F-actin is regulated by tropomyosin. It is the major component of intranuclear and cytoplasmic actin rods. Required for accumulation of actin at the cell division site via depolymerizing actin at the cell ends. In association with myosin II has a role in the assembly of the contractile ring via severing actin filaments. Involved in the maintenance of the contractile ring once formed. In association with [...]


ensembl_gene_id: P78937
symbol: sua1
gene_biotype: protein_coding
description:
  Sulfate adenylyltransferase; Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP. Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur-containing amino acids. Belongs to the sulfate adenylyltransferase family.


ensembl_gene_id: P78953
symbol: mid1
gene_biotype: protein_coding
description:
  Division mal foutue 1 protein; At the onset of mitosis, forms a medial ring structure before the arrangement of the medial actin ring. Essential for the central positioning of the division septum before the cell divides.


ensembl_gene_id: P78954
symbol: tif45
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 4E-1; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures; Belongs to the eukaryotic initiation factor 4E family.


ensembl_gene_id: P78955
symbol: hus1
gene_biotype: protein_coding
description:
  Checkpoint protein hus1; Essential in controlling the S-M checkpoint that couples mitosis to the completion of DNA replication. It is also required for the response to DNA damage.


ensembl_gene_id: P78958
symbol: tdh1
gene_biotype: protein_coding
description:
  Glyceraldehyde-3-phosphate dehydrogenase 1; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.


ensembl_gene_id: P78963
symbol: skb1
gene_biotype: protein_coding
description:
  Protein arginine N-methyltransferase skb1; S-adenosyl-L-methionine-dependent protein-arginine N- methyltransferase that can catalyze both the mono- and symmetric (type II) dimethylation of the guanidino nitrogens of arginine residues in target proteins (By similarity). Positively modulates the shk1 kinase function. May be a mediator of hyperosmotic stress response.


ensembl_gene_id: P78966
symbol: mam1
gene_biotype: protein_coding
description:
  Mating factor M secretion protein mam1; Required in S.pombe M (minus) cells for production of M- factor pheromone. Involved in the transport of the farnesyl-derivation of the M-factor pheromone; Belongs to the ABC transporter superfamily. Alpha-factor sex pheromone exporter (TC 3.A.1.206) family.


ensembl_gene_id: P78970
symbol: lag1
gene_biotype: protein_coding
description:
  Sphingosine N-acyltransferase lag1; Component of the ceramide synthase complex required for C26- CoA-dependent ceramide synthesis. Facilitates ER-to-Golgi transport of GPI-anchored proteins (By similarity). Involved in the aging process (By similarity).


ensembl_gene_id: P78972
symbol: slp1
gene_biotype: protein_coding
description:
  WD repeat-containing protein slp1; Required for mad2-dependent spindle checkpoint activation. Promotes ubiquitin-dependent degradation of cdc13 by the anaphase promoting complex/cyclosome (APC/C).


ensembl_gene_id: P78974
symbol: hem2
gene_biotype: protein_coding
description:
  Delta-aminolevulinic acid dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity).


ensembl_gene_id: P79005
symbol: taz1
gene_biotype: protein_coding
description:
  Telomere length regulator taz1; Regulates telomere length and function. Required for the repression of telomere-adjacent gene expression and for normal meiosis or sporulation. It may be a negative regulator of the telomere- replicating enzyme, telomerase, or may protect against activation of telomerase-independent pathways of telomere elongation. It may be involved in the interactions between chromosomes and spindle proteins, disruption of these interactions would lead to defective meiosis.


ensembl_gene_id: P79007
symbol: php5
gene_biotype: protein_coding
description:
  Transcriptional activator hap5; Component of the CCAAT-bound heteromer, php5 is essential for DNA-binding activity. It is essential for transcription activation of cyc1. It is the linchpin that binds to the subunit association domains (SAD) of php2 and php3 to bring these proteins together.


ensembl_gene_id: P79010
symbol: cox4
gene_biotype: protein_coding
description:
  Cytochrome c oxidase subunit 4, mitochondrial; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane  [...]


ensembl_gene_id: P79011
symbol: tfa2
gene_biotype: protein_coding
description:
  Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase (By similarity).


ensembl_gene_id: P79051
symbol: rhp16
gene_biotype: protein_coding
description:
  ATP-dependent helicase rhp16; Involved in global genome repair (GGR) via nucleotide excision repair (NER), in conjunction with rhp7, after UV irradiation. Belongs to the SNF2/RAD54 helicase family.


ensembl_gene_id: P79058
symbol: igo1
gene_biotype: protein_coding
description:
  mRNA stability protein mug134; Plays an essential role in initiation of the G0 program by preventing the degradation of specific nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway.


ensembl_gene_id: P79060
symbol: sui1
gene_biotype: protein_coding
description:
  Protein translation factor sui1; Additional factor that functions in concert with eIF-2 and the initiator tRNA in directing the ribosome to the proper start site of translation.


ensembl_gene_id: P79063
symbol: erf1
gene_biotype: protein_coding
description:
  Eukaryotic peptide chain release factor subunit 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.


ensembl_gene_id: P79064
symbol: rad31
gene_biotype: protein_coding
description:
  DNA damage tolerance protein rad31; Could be involved in a ubiquitin-related process important for DNA damage tolerance. Acts in a process which is defective in the checkpoint rad mutants and which involves hus5.


ensembl_gene_id: P79065
symbol: tip1
gene_biotype: protein_coding
description:
  Tip elongation protein 1; Has a role in stabilizing and targeting the growing tips of the microtubules along the long axis of the cell, directing them to the ends of the cell. Acts as a cargo for tea2.


ensembl_gene_id: P79082
symbol: mgr2
gene_biotype: protein_coding
description:
  Protein mgr2; Required for cell viability in cells lacking mitochondrial DNA; Belongs to the MGR2 family.


ensembl_gene_id: P79083
symbol: sum1
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 3 subunit I; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.


ensembl_gene_id: P79088
symbol: sec61
gene_biotype: protein_coding
description:
  Protein transport protein sec61 subunit alpha; Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins and is essential for cell growth. It interacts with other membrane proteins required for protein translocation. Upon binding to sec62/63 complex, secretory precursor polypeptides may engage sec61 to begin membrane penetration event. A cycle of assembly and disassembly of sec62/63 from sec61 may govern the activity of the translocase (By similarity).


ensembl_gene_id: P87014
symbol: mam4
gene_biotype: protein_coding
description:
  Protein-S-isoprenylcysteine O-methyltransferase; Mediates C-terminal methylation of the isoprenylated C- terminal cysteine in M-factor.


ensembl_gene_id: P87027
symbol: spg1
gene_biotype: protein_coding
description:
  Septum-promoting GTP-binding protein 1; GTP-binding protein essential for the induction of septum formation at G2 and pre-START stages of mitosis. Acts via the cdc7 protein kinase pathway.


ensembl_gene_id: P87041
symbol: gms1
gene_biotype: protein_coding
description:
  UDP-galactose transporter; Essential for the transport of UDP-galactose into the lumen of Golgi apparatus; Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.


ensembl_gene_id: P87048
symbol: mts4
gene_biotype: protein_coding
description:
  26S proteasome regulatory subunit rpn1; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.


ensembl_gene_id: P87049
symbol: pas1
gene_biotype: protein_coding
description:
  G1/S-specific cyclin pas1; Essential for the control of the cell cycle at the G1/S (start) transition. Interacts with the pef1 protein kinase. The pef1/pas1 complex activates the res2/cdc10 complex.


ensembl_gene_id: P87050
symbol: cdr2
gene_biotype: protein_coding
description:
  Mitosis inducer protein kinase cdr2; Acts as a mitotic inducer. In G2 it negatively regulates wee1, a mitotic inhibitor. Also has a role in cytokinesis where it required for proper septum formation; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.


ensembl_gene_id: P87051
symbol: cyp1
gene_biotype: protein_coding
description:
  Peptidyl-prolyl cis-trans isomerase ppi1; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity); Belongs to the cyclophilin-type PPIase family. PPIL1 subfamily.


ensembl_gene_id: P87053
symbol: pof1
gene_biotype: protein_coding
description:
  F-box/WD repeat-containing protein pof1; Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. Required for the inactivation of zip1 via ubiquitination.


ensembl_gene_id: P87057
symbol: nhp6
gene_biotype: protein_coding
description:
  Non-histone chromosomal protein 6; DNA-binding protein that induces severe bending of DNA. Required for DNA-binding by the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. Also augments the fidelity of transcription by RNA polymerase III independently of any role in the FACT complex (By similarity).


ensembl_gene_id: P87059
symbol: mia40
gene_biotype: protein_coding
description:
  Mitochondrial intermembrane space import and assembly protein 40; Required for the import and folding of small cysteine- containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Forms a redox cycle with ERV1 that involves a disulfide relay system. Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond  [...]


ensembl_gene_id: P87060
symbol: pop1
gene_biotype: protein_coding
description:
  WD repeat-containing protein pop1; Involved in maintenance of ploidy through proteasome dependent degradation of CDK inhibitor rum1 and S-phase initiator cdc18. Functions as a recognition factor for rum1 and cdc18, which are subsequently ubiquitinated and targeted to the 26S proteasome for degradation. Together with pop2, required for cig2 instability during G2 and M phase and cig2 degradation in exponentially growing cells. Regulates cell-cycle progression under starvation through the rum1 protein.


ensembl_gene_id: P87061
symbol: tea1
gene_biotype: protein_coding
description:
  Tip elongation aberrant protein 1; Cell polarity protein. Acts as an end marker, directing the growth machinery to the cell poles. Involved in the regulation of microtubular organization, affecting the maintenance of a single central axis. Prevents the curling of microtubule tips around the cell ends and is required for the retention of polarity factors such as pom1, tip1 and tea2 at the cell ends, necessary for the cell to grow in a straight line. Links tip1 and tea4 in a common complex.


ensembl_gene_id: P87074
symbol: crb2
gene_biotype: protein_coding
description:
  DNA repair protein crb2; Essential for cell cycle arrest at the G1 and G2 stages following DNA damage by X-, and UV-irradiation, or inactivation of DNA ligase. Plays a role in the response to DNA damage. Interaction with rad4 via its phosphorylation sites in the N-terminus couples the DNA checkpoint apparatus to chromatin via interaction of its C-terminal BRCT domains with epigenetic modifications on histones H4 and H2A, respectively, in the G1/S phase of the cell cycle, and facilitates recruitment of the checkpoint kinase chk1.


ensembl_gene_id: P87109
symbol: SPAC20G8.02
gene_biotype: protein_coding
description:
  Probable phospholipase C20G8.02, mitochondrial; Probable phospholipase that hydrolyzes phosphatidic acid. Belongs to the PA-PLA1 family.


ensembl_gene_id: P87111
symbol: SPAC20G8.04c
gene_biotype: protein_coding
description:
  Probable electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial; Accepts electrons from ETF and reduces ubiquinone.


ensembl_gene_id: P87112
symbol: not1
gene_biotype: protein_coding
description:
  General negative regulator of transcription subunit 1; Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery (By similarity).


ensembl_gene_id: P87113
symbol: erg2
gene_biotype: protein_coding
description:
  C-8 sterol isomerase erg2; Catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols. Involved in the biosynthesis or ergosterol which is important for plasma membrane structure and function and for localization of plasma membrane proteins.


ensembl_gene_id: P87114
symbol: fft1
gene_biotype: protein_coding
description:
  ATP-dependent helicase fft1; DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for heterochromatin organization.


ensembl_gene_id: P87115
symbol: nat10
gene_biotype: protein_coding
description:
  RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) at positions 1297 and 1815 in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein tan1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation (By similarity).


ensembl_gene_id: P87117
symbol: atg6
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein atg6; Required for cytoplasm to vacuole transport (Cvt), autophagy, nucleophagy, and mitophagy, as a part of the autophagy-specific vps34 PI3-kinase complex I. This complex is essential to recruit the atg8- phosphatidylinositol conjugate and the atg12-atg5 conjugate to the preautophagosomal structure. Also involved in endosome-to-Golgi retrograde transport as part of the vps34 PI3-kinase complex II (By similarity). Plays a role in meiosis and sporulation.


ensembl_gene_id: P87120
symbol: rpp1
gene_biotype: protein_coding
description:
  Probable ribonuclease P protein subunit 3; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.


ensembl_gene_id: P87121
symbol: taf2
gene_biotype: protein_coding
description:
  Transcription initiation factor TFIID subunit 2; Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by taf1), facilitation of DNA opening and initiation of tra [...]


ensembl_gene_id: P87122
symbol: SPAC3A12.06c
gene_biotype: protein_coding
description:
  Putative cation exchanger C3A12.06c; Putative cation exchanger; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.


ensembl_gene_id: P87123
symbol: rpb11
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerase II subunit RPB11; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft (By similarity).


ensembl_gene_id: P87125
symbol: ure4
gene_biotype: protein_coding
description:
  Uncharacterized urease accessory protein ureD-like; Probably facilitates nickel incorporation; Belongs to the UreD family.


ensembl_gene_id: P87126
symbol: cwf2
gene_biotype: protein_coding
description:
  Pre-mRNA-splicing factor cwf2; Involved in the first step of pre-mRNA splicing. Required for cell growth and cell cycle control. Plays a role in the levels of the U1, U4, U5 and U6 snRNAs and the maintenance of the U4/U6 snRNA complex. May provide the link between the 'nineteen complex' NTC spliceosome protein complex and the spliceosome through the U6 snRNA. Associates predominantly with U6 snRNAs in assembled active spliceosomes. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic [...]


ensembl_gene_id: P87127
symbol: atp11
gene_biotype: protein_coding
description:
  Protein atp11, mitochondrial; Essential for the assembly of the mitochondrial F1-F0 complex. May interact with the alpha and/or beta subunits of F1-ATPase (By similarity); Belongs to the ATP11 family.


ensembl_gene_id: P87128
symbol: tif310
gene_biotype: protein_coding
description:
  Probable eukaryotic translation initiation factor 3 subunit J; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.


ensembl_gene_id: P87129
symbol: vps53
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 53; Involved in retrograde transport from early and late endosomes to late Golgi, leading to the membrane fusion between late Golgi and endosomal vesicles.


ensembl_gene_id: P87130
symbol: tim17
gene_biotype: protein_coding
description:
  Mitochondrial import inner membrane translocase subunit tim17; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.


ensembl_gene_id: P87131
symbol: cys12
gene_biotype: protein_coding
description:
  Cysteine synthase 2; Putative cysteine synthase that catalyzes the conversion of O-acetyl-L-serine (OAS) into cysteine, the last step in the cysteine biosynthesis pathway. However, in contrast to cysteine synthase cys11, this CS-like protein seems not to function in cysteine biosynthesis, at least under normal growth conditions, although the transcript is produced.


ensembl_gene_id: P87140
symbol: sec21
gene_biotype: protein_coding
description:
  Probable coatomer subunit gamma; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity).


ensembl_gene_id: P87141
symbol: mip1
gene_biotype: protein_coding
description:
  Target of rapamycin complex 1 subunit mip1; Component of TORC1, which regulates multiple cellular processes to control cell growth in response to environmental signals. Tor2 is essential for growth. Nutrient limitation and environmental stress signals cause inactivation of TORC1. Active TORC1 positively controls cell growth and ribosome biogenesis by regulating ribosomal protein gene expression. TORC1 negatively controls G1 cell-cycle arrest, sexual development and amino acid uptake. Represses mating, meiosis and sporulation efficiency by interfering with the functions of the transcrip [...]


ensembl_gene_id: P87145
symbol: vac14
gene_biotype: protein_coding
description:
  Protein VAC14 homolog; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Regulates the synthesis of PtdIns(3,5)P2 by positive activation of FAB1 and by controlling FIG4 localization (By similarity).


ensembl_gene_id: P87146
symbol: tim22
gene_biotype: protein_coding
description:
  Mitochondrial import inner membrane translocase subunit tim22; Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity).


ensembl_gene_id: P87147
symbol: egd2
gene_biotype: protein_coding
description:
  Nascent polypeptide-associated complex subunit alpha; Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting. The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of th [...]


ensembl_gene_id: P87148
symbol: hrf1
gene_biotype: protein_coding
description:
  Protein transport protein yif1; Required for fusion of ER-derived vesicles with the Golgi during ER-to-Golgi protein transport. May be involved in proper membrane localization of Rab GTPases (By similarity).


ensembl_gene_id: P87149
symbol: mrs2
gene_biotype: protein_coding
description:
  Mitochondrial inner membrane magnesium transporter mrs2; High-conductance magnesium-selective channel that mediates the influx of magnesium into the mitochondrial matrix. Essential for the splicing of mRNA group II introns in mitochondria by affecting mitochondrial magnesium concentrations, which are critical for group II intron splicing. It also suppresses a variety of mitochondrial intron mutations and its absence may disturb the assembly of mitochondrial membrane complexes.


ensembl_gene_id: P87150
symbol: mic19
gene_biotype: protein_coding
description:
  MICOS complex subunit mic19; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.


ensembl_gene_id: P87152
symbol: spt7
gene_biotype: protein_coding
description:
  Transcriptional activator spt7; Functions as component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and SLIK. SAGA is involved in RNA polymerase II-dependent transcriptional regulation. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. SAGA acetylates nucleosoma [...]


ensembl_gene_id: P87153
symbol: cct7
gene_biotype: protein_coding
description:
  Probable T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity).


ensembl_gene_id: P87154
symbol: cdc20
gene_biotype: protein_coding
description:
  DNA polymerase epsilon catalytic subunit A; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.


ensembl_gene_id: P87156
symbol: trs401
gene_biotype: protein_coding
description:
  Probable 20S rRNA accumulation protein 4; Required for processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; Belongs to the TSR4 family.


ensembl_gene_id: P87157
symbol: gga22
gene_biotype: protein_coding
description:
  Probable ADP-ribosylation factor-binding protein C25H2.16c; May play a role in the regulation of membrane traffic through the trans-Golgi network; Belongs to the GGA protein family.


ensembl_gene_id: P87159
symbol: nif1
gene_biotype: protein_coding
description:
  Mitosis inhibitor nif1; Functions as a negative regulator of mitosis. It interacts with the C-terminal of nim1, thereby inhibiting its kinase activity which phosphorylates wee1.


ensembl_gene_id: P87168
symbol: trz2
gene_biotype: protein_coding
description:
  Ribonuclease Z 2, mitochondrial; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. May be involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. Belongs to the RNase Z family.


ensembl_gene_id: P87169
symbol: mad1
gene_biotype: protein_coding
description:
  Spindle assembly checkpoint component mad1; Central component of the spindle assembly checkpoint. Has a role in the correct positioning of the septum. Required for anchoring mad2 to the nuclear periphery.


ensembl_gene_id: P87170
symbol: ptp4
gene_biotype: protein_coding
description:
  CTP-dependent diacylglycerol kinase 1; CTP-dependent diacylglycerol kinase that catalyzes the phosphorylation of diacylglycerol (DAG) to phosphatidate (PA). Controls phosphatidate levels at the nuclear envelope. Counteracts the activity of ned1. May be involved in vesicle trafficking between the endoplasmic reticulum and the Golgi apparatus (By similarity). Involved in pre-tRNA splicing; Belongs to the DGK1 family.


ensembl_gene_id: P87171
symbol: prs5
gene_biotype: protein_coding
description:
  Ribose-phosphate pyrophosphokinase 5; 5-phosphoribose 1-diphosphate synthase involved in nucleotide, histidine, and tryptophan biosynthesis. Active in heteromultimeric complexes with other 5-phosphoribose 1-diphosphate synthases (By similarity); Belongs to the ribose-phosphate pyrophosphokinase family.


ensembl_gene_id: P87172
symbol: gpi3
gene_biotype: protein_coding
description:
  Phosphatidylinositol N-acetylglucosaminyltransferase gpi3 subunit; Catalytic subunit in the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis. Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.


ensembl_gene_id: P87173
symbol: lsm1
gene_biotype: protein_coding
description:
  U6 snRNA-associated Sm-like protein LSm1; Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation by activating the decapping step. The LSM1-LSM7 complex binds RNA with a preference for poly-U ends.


ensembl_gene_id: P87174
symbol: dpb4
gene_biotype: protein_coding
description:
  DNA polymerase epsilon subunit D; As accessory component of the DNA polymerase epsilon (DNA polymerase II) participates in chromosomal DNA replication. It is required during synthesis of the leading and lagging DNA strands at the replication fork and binds at/or near replication origins and moves along DNA with the replication fork. It has 3'-5' proofreading exonuclease activity that correct errors arising during DNA replication. It is also involved in DNA synthesis during DNA repair (By similarity). The dpb3-dpb4 dimer associates with histone deacetylases, chromatin remodelers, and hi [...]


ensembl_gene_id: P87175
symbol: apn2
gene_biotype: protein_coding
description:
  DNA-(apurinic or apyrimidinic site) lyase 2; DNA repair enzyme that cleaves apurinic/apyrimidinic (AP) sites and removes 3'-blocking groups present at single strand breaks of damaged DNA. Provides the majority of the AP-endonuclease (APE) activity. Repairs phleomycin D1-induced DNA damage. Plays a role in oxidative damage repair; Belongs to the DNA repair enzymes AP/ExoA family.


ensembl_gene_id: P87176
symbol: slx8
gene_biotype: protein_coding
description:
  E3 ubiquitin-protein ligase complex slx8-rfp subunit slx8; Mediates ubiquitination and subsequent desumoylation/degradation of sumoylated proteins and proteins containing SUMO-like domains. Acts as a critical suppressor of gross chromosomal rearrangements (GCRs) during normal cell cycle progression. Involved in stabilizing, restarting or resolving transiently stalled replication forks. Prevents accumulation of DNA damage during cell cycle progression (By similarity).


ensembl_gene_id: P87214
symbol: hem4
gene_biotype: protein_coding
description:
  Uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.


ensembl_gene_id: P87215
symbol: dim1
gene_biotype: protein_coding
description:
  Mitosis protein dim1; Plays a fundamental role as a protein essential for entry into mitosis (G2/M progression) as well as for chromosome segregation during mitosis. May play a role in mitotic spindle formation and/or function. May have a role in the maintenance or establishment of the steady-state level of the APC complex.


ensembl_gene_id: P87227
symbol: mis6
gene_biotype: protein_coding
description:
  Inner kinetochore subunit mis6; Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly. Required for the localization of cnp1 to the centromere ; Belongs to the CENP-I/CTF3 family.


ensembl_gene_id: P87228
symbol: ser3
gene_biotype: protein_coding
description:
  Putative D-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.


ensembl_gene_id: P87230
symbol: coq5
gene_biotype: protein_coding
description:
  2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl- 6-methoxy-1,4-benzoquinol (DMQH2).


ensembl_gene_id: P87231
symbol: mus81
gene_biotype: protein_coding
description:
  Crossover junction endonuclease mus81; Interacts with eme1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single- end invasion (SEI). Belongs to the XPF family.


ensembl_gene_id: P87233
symbol: phf1
gene_biotype: protein_coding
description:
  SWM histone demethylase complex subunit phf1; Component of the SWM histone demethylase complex that specifically demethylates H3K9me2, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Has a role in regulating heterochromatin propagation and euchromatic transcription.


ensembl_gene_id: P87235
symbol: rhp42
gene_biotype: protein_coding
description:
  DNA repair protein rhp42; Has a role in the nucleotide excision repair (NER) pathway. Acts in both transcription-coupled repair (TCR) which removes damage from the transcribed strand of active genes and in global genome repair (GGR) which removes damage in untranscribed DNA. Involved in the repair of short-patch mismatch during meiosis; Belongs to the XPC family.


ensembl_gene_id: P87240
symbol: not2
gene_biotype: protein_coding
description:
  General negative regulator of transcription subunit 2; Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. NOT2 is required for the integrity of the complex. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery (By similarity); Belongs to the CNOT2/3 [...]


ensembl_gene_id: P87241
symbol: rib2
gene_biotype: protein_coding
description:
  Diaminohydroxyphosphoribosylamino-pyrimidine deaminase; Involved in riboflavin biosynthesis. Converts 2,5-diamino-6- (ribosylamino)-4(3H)-pyrimidinone 5'-phosphate into 5-amino-6- (ribosylamino)-2,4(1H,3H)-pyrimidinedione 5'-phosphate (By similarity).


ensembl_gene_id: P87243
symbol: rix1
gene_biotype: protein_coding
description:
  Pre-rRNA-processing protein rix1; Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA and the nucleoplasmic transit of the pre- 60S ribosomal subunits. Regulates pre-60S association of the critical remodeling factor mdn1 (By similarity). Also required for heterochromatic gene silencing.


ensembl_gene_id: P87244
symbol: alp16
gene_biotype: protein_coding
description:
  Spindle pole body component alp16; Component of the gamma tubule complex that is required for the regulation of both interphase microtubules and mitotic bipolar spindles.


ensembl_gene_id: P87245
symbol: kms1
gene_biotype: protein_coding
description:
  Karyogamy meiotic segregation protein 1; Has a role in karyogamy, recombination and segregation during meiosis. Although it has been shown to associate with the spindle pole body it is unlikely to be involved in its formation or maintenance.


ensembl_gene_id: P87294
symbol: sub1
gene_biotype: protein_coding
description:
  Putative RNA polymerase II transcriptional coactivator; General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. Binds single-stranded DNA (By similarity).


ensembl_gene_id: P87297
symbol: dad1
gene_biotype: protein_coding
description:
  DASH complex subunit dad1; Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore. Mediates interaction between the DASH and sim4 complexes leading to loading of DASH onto the kinetochore.


ensembl_gene_id: P87303
symbol: tfb2
gene_biotype: protein_coding
description:
  General transcription and DNA repair factor IIH subunit tfb2; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has be [...]


ensembl_gene_id: P87305
symbol: ggg1
gene_biotype: protein_coding
description:
  Glutathione-specific gamma-glutamylcyclotransferase; Gamma-glutamylcyclotransferase acting specifically on glutathione, but not on other gamma-glutamyl peptides. Allows utilization of gluthathione through subsequent cleavage of the Cys-Gly dipeptide by Cys-Gly metallodipeptidase dug1.


ensembl_gene_id: P87306
symbol: srb4
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 17; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.


ensembl_gene_id: P87308
symbol: lsb5
gene_biotype: protein_coding
description:
  Protein lsb5; Essential for the organization of the actin cytoskeleton, fluid phase endocytosis and vesicle trafficking; Belongs to the LSB5 family.


ensembl_gene_id: P87309
symbol: mde2
gene_biotype: protein_coding
description:
  Mei4-dependent protein 2; Required for the formation of meiotic double-strand breaks and for the segregation of homologous centromeres during meiosis I. Interacts with the SFT and DSBC complexes, two subcomplexes involved in the formation of meiotic double-strand breaks. Stabilizes the SFT subcomplex on DSB sites and recruits the DSBC subcomplex onto DSB sites.


ensembl_gene_id: P87310
symbol: nut2
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 10; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.


ensembl_gene_id: P87312
symbol: cwf4
gene_biotype: protein_coding
description:
  Pre-mRNA-splicing factor cwf4; Involved in pre-mRNA splicing and cell cycle progression. Required for the spliceosome assembly and initiation of the DNA replication (By similarity); Belongs to the crooked-neck family.


ensembl_gene_id: P87314
symbol: hip1
gene_biotype: protein_coding
description:
  Protein hir1; Probably required for replication-independent chromatin assembly. Required for transcriptional silencing in the outer repeat (otr) centromeric repeats and the Tf2 long terminal repeat retrotransposons. Repressor of histone gene transcription in G1 arrested cells. Required for repression of htb1 gene expression outside of S phase; Belongs to the WD repeat HIR1 family.


ensembl_gene_id: P87315
symbol: hip3
gene_biotype: protein_coding
description:
  Histone transcription regulator 3 homolog; Has a role in a nucleosome assembly pathway that is required for the integrity of heterochromatin and proper chromosome segregation. Required for transcriptional silencing in the outer repeat (otr) region of centromeric repeats and the Tf2 long terminal repeat retrotransposons; Belongs to the HIR3 family.


ensembl_gene_id: P87316
symbol: atp15
gene_biotype: protein_coding
description:
  Putative ATP synthase subunit epsilon, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechan [...]


ensembl_gene_id: P87319
symbol: vps1301
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 13a; May be involved in recycling of membrane proteins between an endocytic compartment and the TGN; Belongs to the VPS13 family.


ensembl_gene_id: P87320
symbol: msp1
gene_biotype: protein_coding
description:
  Protein msp1, mitochondrial; Dynamin-related GTPase required for mitochondrial fusion. Coordinates interaction between the inner and outer mitochondrial membrane to promote the formation of the double membrane (By similarity).


ensembl_gene_id: P87323
symbol: mcs4
gene_biotype: protein_coding
description:
  Response regulator mcs4; Response regulator that coordinately controls the stress activated wak1-wis1-sty1 MAP kinase pathway and fission yeast cell cycle.


ensembl_gene_id: P87324
symbol: cdc1
gene_biotype: protein_coding
description:
  DNA polymerase subunit delta-2; Required for replication of the leading DNA strand and for completion of lagging strand synthesis. It is essential for cell cycle progression.


ensembl_gene_id: Q00619
symbol: mam2
gene_biotype: protein_coding
description:
  Pheromone P-factor receptor; Receptor for the peptide pheromone P-factor, a mating factor of S.pombe. Pheromone signaling is essential for initiation of meiosis in S.pombe; P-factor signaling alone may be sufficient; Belongs to the G-protein coupled receptor 4 family.


ensembl_gene_id: Q01112
symbol: cdc42
gene_biotype: protein_coding
description:
  Cell division control protein 42 homolog; Involved in development of cell polarity during the cell division cycle; Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.


ensembl_gene_id: Q01475
symbol: sar1
gene_biotype: protein_coding
description:
  Small COPII coat GTPase sar1; Small GTPase component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. Sar1 controls the coat assembly in a stepwise manner. Activated sar1-GTP binds to membranes first and recruits the SEC23/24 complex. These sec23/24-sar1 prebudding intermediates are then collected by the sec13/31 complex as subunits polymerize to form coated trans [...]


ensembl_gene_id: Q01663
symbol: pap1
gene_biotype: protein_coding
description:
  AP-1-like transcription factor; Transcription activator involved in multidrug resistance, oxidative stress response, and redox homeostasis. Regulates the transcription of genes encoding antioxidant enzymes like catalase ctt1 and components of the cellular thiol-reducing pathways, including the thioredoxin system (trx2, trr1), ABC tansporters involved in multidrug resistance like bfr1/hba2 and pmd1 as well as the gene obr1/apt1. Preferentially binds to promoters with the core binding site 5'- TTA[CG]TAA-3'. Activity of the transcription factor is controlled through oxidation of specific [...]


ensembl_gene_id: Q01682
symbol: pho4
gene_biotype: protein_coding
description:
  Thiamine-repressible acid phosphatase pho4; May dephosphorylate thiamine phosphates; Belongs to the histidine acid phosphatase family.


ensembl_gene_id: Q02061
symbol: rpb2
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerase II subunit RPB2; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB2 is  [...]


ensembl_gene_id: Q02099
symbol: rad3
gene_biotype: protein_coding
description:
  Protein kinase rad3; Serine/threonine kinase which activates checkpoint signaling upon genotoxic stresses. Involved in G2 arrest following DNA damage where it phosphorylates chk1. Phosphorylation of 'Thr-73' and 'Ser-80' of checkpoint mediator crb2 promotes its interaction with chk1. It is also involved in the dependence of mitosis on the completion of DNA replication ; Belongs to the PI3/PI4-kinase family. ATM subfamily.


ensembl_gene_id: Q02592
symbol: hmt1
gene_biotype: protein_coding
description:
  Heavy metal tolerance protein; Involved in metal tolerance. Probably involved in the transport of metal-bound phytochelatins. Compartmentalizes cadmium within vacuoles, thereby protecting cells from cadmium toxicity; Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.


ensembl_gene_id: Q02787
symbol: ade2
gene_biotype: protein_coding
description:
  Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. Belongs to the adenylosuccinate synthetase family.


ensembl_gene_id: Q02953
symbol: hsf1
gene_biotype: protein_coding
description:
  Heat shock factor protein; DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. Also required for growth at normal temperatures.


ensembl_gene_id: Q03319
symbol: prh1
gene_biotype: protein_coding
description:
  Probable ATP-dependent RNA helicase prh1; May be involved in pre-mRNA splicing; Belongs to the DEAD box helicase family. DEAH subfamily.


ensembl_gene_id: Q03392
symbol: pcn1
gene_biotype: protein_coding
description:
  Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.


ensembl_gene_id: Q04635
symbol: esc1
gene_biotype: protein_coding
description:
  Protein esc1; Involved in the sexual differentiation process. Modulate the ability of the cell to differentiate in response to the nitrogen starvation signal; in particular in response to decreases in the level of cellular cAMP.


ensembl_gene_id: Q04665
symbol: gpa2
gene_biotype: protein_coding
description:
  Guanine nucleotide-binding protein alpha-2 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. This protein may be involved in the determination of the cAMP level according to nutritional conditions, most probably as a regulator of adenylyl cyclase; Belongs to the G-alpha family.


ensembl_gene_id: Q04800
symbol: frp1
gene_biotype: protein_coding
description:
  Ferric reductase transmembrane component 1; Metalloreductase responsible for reducing extracellular iron and copper prior to import (By similarity). Catalyzes the reductive uptake of Fe(3+)-salts and Fe(3+) bound to catecholate or hydroxamate siderophores (By similarity). Fe(3+) is reduced to Fe(2+), which then dissociates from the siderophore and can be imported by the high- affinity Fe(2+) transport complex in the plasma membrane (By similarity). Also participates in Cu(2+) reduction and Cu(+) uptake (By similarity).


ensembl_gene_id: Q06182
symbol: swi10
gene_biotype: protein_coding
description:
  Mating-type switching protein swi10; Involved in termination of copy-synthesis during mating-type switching. Involved in nucleotide excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents. Along with RAD16 forms an endonuclease that specifically degrades single-stranded DNA; Belongs to the ERCC1/RAD10/SWI10 family.


ensembl_gene_id: Q06975
symbol: gar1
gene_biotype: protein_coding
description:
  H/ACA ribonucleoprotein complex subunit gar1; Non-catalytic component of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP), which catalyzes pseudouridylation of rRNA and is required for ribosome biogenesis. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs. The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs. The H/ACA snoRNP complex mediates pseudouridylation at position 93 in U2 snRNA.


ensembl_gene_id: Q07538
symbol: prp4
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase prp4; Has a role in pre-mRNA splicing and is essential for growth. Phosphorylates srp1.


ensembl_gene_id: Q08I43
symbol: eri1
gene_biotype: protein_coding
description:
  3'-5' exonuclease eri1; RNA exonuclease that acts as a negative regulator of RNA interference (RNAi). Acts by degrading the 3'-overhangs of double- stranded short interfering RNAs (siRNAs). Represses the accumulation of heterochromatic siRNAs leading to negative regulation of the RNAi- mediated heterochromoatin assembly. Also involved in rRNA biogenesis, trimming the 5.8S ribosomal RNA (rRNA) from a slightly longer pre-5.8S RNA in the cytoplasm.


ensembl_gene_id: Q09094
symbol: rec15
gene_biotype: protein_coding
description:
  Meiotic recombination protein rec15; Required during the early stages of meiosis for meiotic recombination. Involved in chromosome segregation where it is required for separation of sister chromatids in all three chromosomes.


ensembl_gene_id: Q09116
symbol: spn2
gene_biotype: protein_coding
description:
  Septin homolog spn2; Plays a role in the cell cycle. Involved in a late stage of septum formation leading to the separation of the daughter cells. Involved in the correct orientation of forespore membrane extension during sporulation. Binds phosphatidylinositol 4-phosphate.


ensembl_gene_id: Q09130
symbol: tif213
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 2 subunit gamma; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction cat [...]


ensembl_gene_id: Q09140
symbol: gpt1
gene_biotype: protein_coding
description:
  UDP-glucose:glycoprotein glucosyltransferase; Selectively reglucosylates unfolded glycoproteins, thus providing quality control for protein transport out of the ER. Unfolded, denatured glycoproteins are substantially better substrates for glucosylation by this enzyme than are the corresponding native proteins. This protein and transient glucosylation may be involved in monitoring and/or assisting the folding and assembly of newly made glycoproteins, in order to identify glycoproteins that need assistance in folding from chaperones; Belongs to the glycosyltransferase 8 family.


ensembl_gene_id: Q09142
symbol: orc2
gene_biotype: protein_coding
description:
  Origin recognition complex subunit 2; Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. ORC binds to multiple sites within the ars1 origin of DNA replication in an ATP-independent manner; Belongs to the ORC2 family.


ensembl_gene_id: Q09150
symbol: rec14
gene_biotype: protein_coding
description:
  Meiotic recombination protein rec14; Required for formation of the rec12-mediated double-strand breaks (DSBs) that initiate meiotic recombination.


ensembl_gene_id: Q09154
symbol: rip1
gene_biotype: protein_coding
description:
  Cytochrome b-c1 complex subunit Rieske, mitochondrial; Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical g [...]


ensembl_gene_id: Q09170
symbol: cds1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase cds1; Has a role in the DNA replication-monitoring S/G2 checkpoint system. It is responsible for blocking mitosis in the S phase. It monitors DNA synthesis by interacting with DNA polymerase alpha and sends a signal to block the onset of mitosis while DNA synthesis is in progress. Phosphorylates rad60 and dna2. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.


ensembl_gene_id: Q09171
symbol: pdb1
gene_biotype: protein_coding
description:
  Pyruvate dehydrogenase E1 component subunit beta, mitochondrial; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).


ensembl_gene_id: Q09172
symbol: ptc2
gene_biotype: protein_coding
description:
  Protein phosphatase 2C homolog 2; Has an important role in osmotic stability and cell shape control. It may negatively regulate the osmosensing signal transmitted through wis1 map kinase.


ensembl_gene_id: Q09173
symbol: ptc3
gene_biotype: protein_coding
description:
  Protein phosphatase 2C homolog 3; Has an important role in osmotic stability and cell shape control. It may negatively regulate the osmosensing signal transmitted through wis1 map kinase.


ensembl_gene_id: Q09174
symbol: gma12
gene_biotype: protein_coding
description:
  Alpha-1,2-galactosyltransferase; Involved in the O- and N-linked oligosaccharide modification of proteins transported through the Golgi stack. This occurs in cis Golgi where the enzyme transfers galactose from UDP-galactose to a variety of mannose based acceptors.


ensembl_gene_id: Q09175
symbol: krp1
gene_biotype: protein_coding
description:
  Dibasic-processing endoprotease; Membrane-bound, subtilisin-like serine protease that processes the P-factor precursor and other precursor proteins. Essential for cell viability. Cleaves substrate on the C-terminal side of dibasic residues; Belongs to the peptidase S8 family. Furin subfamily.


ensembl_gene_id: Q09176
symbol: uaf2
gene_biotype: protein_coding
description:
  Splicing factor U2AF 23 kDa subunit; Necessary for the splicing of pre-mRNA. The SF1-U2AF59-U2AF23 complex has a role in the recognition of the branch site (5'-UACUAAC- 3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.


ensembl_gene_id: Q09177
symbol: rpc19
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerases I and III subunit RPAC2; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively.


ensembl_gene_id: Q09180
symbol: map2
gene_biotype: protein_coding
description:
  P-factor-like 1; In h- cells under nutritional starvation, P-factor induces alteration of cell morphology toward mating, arrest of the cell cycle at the G1 phase prior to the initiation of DNA synthesis and indirect transcriptional activation of the sxa2 gene which down-regulates the signaling pathway.


ensembl_gene_id: Q09181
symbol: ste13
gene_biotype: protein_coding
description:
  Putative ATP-dependent RNA helicase ste13; ATP-dependent RNA helicase involved in mRNA turnover, and more specifically in mRNA decapping. Is involved in G1/S DNA-damage checkpoint recovery, probably through the regulation of the translational status of a subset of mRNAs. May also have a role in translation and mRNA nuclear export (By similarity); Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.


ensembl_gene_id: Q09184
symbol: cdb4
gene_biotype: protein_coding
description:
  Curved DNA-binding protein; A non-essential protein that preferentially binds curved DNA. Binds non-curved DNA with a much lower affinity; Belongs to the peptidase M24 family.


ensembl_gene_id: Q09188
symbol: anc1
gene_biotype: protein_coding
description:
  ADP,ATP carrier protein; Catalyzes the exchange of ADP and ATP across the mitochondrial inner membrane; Belongs to the mitochondrial carrier (TC 2.A.29) family.


ensembl_gene_id: Q09190
symbol: cdd1
gene_biotype: protein_coding
description:
  Putative cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.


ensembl_gene_id: Q09191
symbol: rpb5
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerases I, II, and III subunit RPABC1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RPB5 is part of the lower  [...]


ensembl_gene_id: Q09195
symbol: erg24
gene_biotype: protein_coding
description:
  Delta(14)-sterol reductase; Reduces the C14=C15 double bond of 4,4-dimethyl-cholesta- 8,14,24-trienol to produce 4,4-dimethyl-cholesta-8,24-dienol. Belongs to the ERG4/ERG24 family.


ensembl_gene_id: Q09196
symbol: cdc4
gene_biotype: protein_coding
description:
  Myosin regulatory light chain cdc4; Involved in cytokinesis. Required for the formation and function of the contractile ring.


ensembl_gene_id: Q09330
symbol: mlo3
gene_biotype: protein_coding
description:
  mRNA export protein mlo3; Has a role in the mRNA export process. Interferes with mitotic chromosome segregation when overexpressed.


ensembl_gene_id: Q09669
symbol: adh4
gene_biotype: protein_coding
description:
  Alcohol dehydrogenase 4; Involved in ethanol oxidation in mitochondria. Belongs to the iron-containing alcohol dehydrogenase family.


ensembl_gene_id: Q09675
symbol: hsp3102
gene_biotype: protein_coding
description:
  Glutathione-independent glyoxalase hsp3102; Catalyzes the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step. May play a role in detoxifying endogenously produced glyoxals. Involved in protection against reactive oxygen species (ROS) (By similarity). Belongs to the peptidase C56 family. HSP31-like subfamily.


ensembl_gene_id: Q09676
symbol: SPAC5H10.03
gene_biotype: protein_coding
description:
  Probable phosphatase SPAC5H10.03; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily.


ensembl_gene_id: Q09682
symbol: pre9
gene_biotype: protein_coding
description:
  Probable proteasome subunit alpha type-3; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity); Belongs to the peptidase T1A family.


ensembl_gene_id: Q09683
symbol: mre11
gene_biotype: protein_coding
description:
  DNA repair protein rad32; Required for the repair of double strand breaks (DSB) caused by gamma and UV radiation. May work in conjunction with rhp51; Belongs to the MRE11/RAD32 family.


ensembl_gene_id: Q09684
symbol: tht1
gene_biotype: protein_coding
description:
  Nuclear fusion protein tht1; Required for nuclear membrane fusion during karyogamy. Belongs to the KAR5 family.


ensembl_gene_id: Q09687
symbol: SPAC13C5.05c
gene_biotype: protein_coding
description:
  Phosphoacetylglucosamine mutase 1; Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, which is a biosynthetic precursor of chitin and also supplies the amino sugars for N-linked oligosaccharides of glycoproteins.


ensembl_gene_id: Q09689
symbol: tif5
gene_biotype: protein_coding
description:
  Probable eukaryotic translation initiation factor 5; Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]) (By similarity); Belongs to the eIF-2-beta/eIF-5 family.


ensembl_gene_id: Q09690
symbol: pom1
gene_biotype: protein_coding
description:
  DYRK-family kinase pom1; Polarity factor involved in localization of polarized growth and cytokinesis. Forms an intracellular gradient that serves to measure cell length and control mitotic entry. Controls the timing of mitotic commitment by regulating the inhibitory impact of cdr1/cdr2 on wee1 activity. Directly phosphorylates the tail of cdr2 which inhibits cdr2 activation by ssp1. Cdr2 phosphorylation by pom1 also modulates cdr2 association with membranes and inhibits cdr2 interaction with mid1, reducing its clustering ability, possibly via the down-regulation of cdr2 kinase activit [...]


ensembl_gene_id: Q09691
symbol: mrf1
gene_biotype: protein_coding
description:
  Putative peptide chain release factor 1, mitochondrial; Belongs to the prokaryotic/mitochondrial release factor family.


ensembl_gene_id: Q09693
symbol: pol4
gene_biotype: protein_coding
description:
  DNA polymerase type-X family protein pol4; Repair polymerase. Involved in gap-filling in DNA non- homologous end joining (NHEJ) required for double-strand break repair. Can incorporate a ribonucleotide (rNTP) into a primer DNA. Belongs to the DNA polymerase type-X family.


ensembl_gene_id: Q09694
symbol: lys3
gene_biotype: protein_coding
description:
  Saccharopine dehydrogenase [NAD(+), L-lysine-forming]; Catalyzes the NAD(+)-dependent cleavage of saccharopine to L- lysine and 2-oxoglutarate, the final step in the alpha-aminoadipate (AAA) pathway for lysin biosynthesis; Belongs to the AlaDH/PNT family.


ensembl_gene_id: Q09696
symbol: med1
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.


ensembl_gene_id: Q09697
symbol: rga8
gene_biotype: protein_coding
description:
  Rho-GTPase-activating protein 8; Acts in signal transduction. Negatively regulates the pak1/shk1 control pathway.


ensembl_gene_id: Q09699
symbol: snf5
gene_biotype: protein_coding
description:
  SWI/SNF chromatin-remodeling complex subunit snf5; Component of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors.


ensembl_gene_id: Q09701
symbol: akr1
gene_biotype: protein_coding
description:
  Palmitoyltransferase akr1; Palmitoyltransferase specific for casein kinase 1. Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.


ensembl_gene_id: Q09702
symbol: nrd1
gene_biotype: protein_coding
description:
  Negative regulator of differentiation 1; Negative regulator of sexual differentiation. Acts by repressing the transcription of meiosis-inducing, ste11-regulated genes until cells reach a critical level of starvation. RNA-binding protein that preferentially binds poly(U).


ensembl_gene_id: Q09704
symbol: rrp4
gene_biotype: protein_coding
description:
  Exosome complex component rrp4; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm [...]


ensembl_gene_id: Q09705
symbol: rsm24
gene_biotype: protein_coding
description:
  37S ribosomal protein S24, mitochondrial; Involved in mitochondrial genome encoded proteins translation.


ensembl_gene_id: Q09706
symbol: pld1
gene_biotype: protein_coding
description:
  Phospholipase D1; Required for meiosis and spore formation. Seems to be involved in the coordinate induction of late meiotic events.


ensembl_gene_id: Q09711
symbol: ncs1
gene_biotype: protein_coding
description:
  Calcium-binding protein NCS-1; Negatively regulates sporulation perhaps by controlling Ca(2+)-dependent desensitization of git3.


ensembl_gene_id: Q09712
symbol: gpi18
gene_biotype: protein_coding
description:
  GPI mannosyltransferase 2; Mannosyltransferase involved in glycosylphosphatidylinositol- anchor biosynthesis. Responsible for the transfer of the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly (By similarity); Belongs to the PIGV family.


ensembl_gene_id: Q09717
symbol: sbp1
gene_biotype: protein_coding
description:
  Ran-specific GTPase-activating protein 1; Stimulates the GTPase activity in the presence of RNA1. May potentiate the action of RanGAP1 (RNA1), thus playing the role of a negative regulator; Belongs to the RANBP1 family.


ensembl_gene_id: Q09718
symbol: apm4
gene_biotype: protein_coding
description:
  AP-2 complex subunit mu; Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. AP50 is a subunit of the plasma membrane adaptor (Potential).


ensembl_gene_id: Q09719
symbol: dbp10
gene_biotype: protein_coding
description:
  ATP-dependent RNA helicase dbp10; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.


ensembl_gene_id: Q09720
symbol: pre1
gene_biotype: protein_coding
description:
  Probable proteasome subunit beta type-4; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity); Belongs to the peptidase T1B family.


ensembl_gene_id: Q09722
symbol: tif313
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 3 subunit M; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.


ensembl_gene_id: Q09723
symbol: trm112
gene_biotype: protein_coding
description:
  Multifunctional methyltransferase subunit trm112; Acts as an activator of both rRNA/tRNA and protein methyltransferases. Together with methyltransferase mtq2, required for the methylation of eRF1 on 'Gln-182'. Together with methyltransferase trm11, required for the formation of 2-methylguanosine at position 10 (m2G10) in tRNA. Together with methyltransferase bud23, required for the formation of a 7-methylguanine in 18S rRNA. Involved in biogenesis of both 40S and 60S ribosomal subunits (By similarity).


ensembl_gene_id: Q09724
symbol: mrp11
gene_biotype: protein_coding
description:
  54S ribosomal protein L11, mitochondrial; Involved in mitochondrial genome encoded proteins translation.


ensembl_gene_id: Q09725
symbol: mis4
gene_biotype: protein_coding
description:
  Sister chromatid cohesion protein mis4; Plays a structural role in chromatin. Chromatid cohesion molecule required for equal sister chromatid separation in anaphase. May form a stable link between chromatids in S phase that is split rather than removed in anaphase. Also required for spindle-kinetochore interaction in early mitosis and inhibit sister chromatid separation until the cleavage of Rad21 in anaphase; Belongs to the SCC2/Nipped-B family.


ensembl_gene_id: Q09726
symbol: atp25
gene_biotype: protein_coding
description:
  ATPase synthesis protein 25, mitochondrial; mRNA stabilization factor specific for the 0.95 kb oli1 mRNA. Also involved in oli1 ring formation (By similarity); Belongs to the ATP25 family.


ensembl_gene_id: Q09727
symbol: mrp20
gene_biotype: protein_coding
description:
  54S ribosomal protein L23, mitochondrial; Involved in mitochondrial genome encoded proteins translation.


ensembl_gene_id: Q09728
symbol: cuf1
gene_biotype: protein_coding
description:
  Metal-binding regulatory protein cuf1; Copper-sensing transcription factor that regulates iron uptake genes. Under copper starvation conditions activates the transcription of the copper transport genes, ctr4, ctr5 and ctr6.


ensembl_gene_id: Q09730
symbol: sft1
gene_biotype: protein_coding
description:
  Protein transport protein sft1; Vesicle SNARE required for retrograde transport within the Golgi complex.


ensembl_gene_id: Q09731
symbol: bun107
gene_biotype: protein_coding
description:
  UBP9-binding protein bun107; Required for the ubp9 recruitment to septa and cell tips but also for its enzymatic activity at these specific locations.


ensembl_gene_id: Q09732
symbol: dcc1
gene_biotype: protein_coding
description:
  Sister chromatid cohesion protein dcc1; Essential for the fidelity of chromosome transmission. Required for the DNA replication block checkpoint. Replication factor C (RFC) complex has an essential but redundant activity in sister chromatid cohesion establishment. An RFC-like complex (ctf18-RFC) is formed where ctf18 replaces rfc1 in the RFC complex along with the association of dcc1 and ctf8. This complex is required for efficient establishment of chromosome cohesion during S-phase. Acts as a PCNA loader, loading PCNA onto primed templates.


ensembl_gene_id: Q09733
symbol: gef2
gene_biotype: protein_coding
description:
  Rho guanine nucleotide exchange factor gef2; Has a role in the control of cell polarity and cytokinesis. Involved in bipolar growth and septum formation.


ensembl_gene_id: Q09736
symbol: erg11
gene_biotype: protein_coding
description:
  Lanosterol 14-alpha demethylase erg11; Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'- dimethyl cholesta-8,14,24-triene-3-beta-ol.


ensembl_gene_id: Q09740
symbol: gfa1
gene_biotype: protein_coding
description:
  Probable glutamine--fructose-6-phosphate aminotransferase [isomerizing]; Involved in amino sugar synthesis (formation of chitin, supplies the amino sugars of asparagine-linked oligosaccharides of glycoproteins).


ensembl_gene_id: Q09743
symbol: ste20
gene_biotype: protein_coding
description:
  Target of rapamycin complex 2 subunit ste20; Component of TORC2, which regulates multiple cellular processes to control cell growth in response to environmental signals. TORC2 is required for cell survival under various stress conditions. TORC2 positively controls G1 cell-cycle arrest, sexual development and amino acid uptake. Positively regulates amino acid uptake through the control of expression of amino acid permeases. Belongs to the RICTOR family.


ensembl_gene_id: Q09746
symbol: bzz1
gene_biotype: protein_coding
description:
  Protein BZZ1; Plays a role in endocytosis and trafficking to the vacuole. Functions with type I myosins to restore polarity of the actin cytoskeleton after NaCl stress (By similarity); Belongs to the BZZ1 family.


ensembl_gene_id: Q09747
symbol: dbp5
gene_biotype: protein_coding
description:
  ATP-dependent RNA helicase dbp5; ATP-dependent RNA helicase associated with the nuclear pore complex and essential for mRNA export from the nucleus. May participate in a terminal step of mRNA export through the removal of proteins that accompany mRNA through the nucleopore complex. May also be involved in early transcription (By similarity).


ensembl_gene_id: Q09748
symbol: dnm1
gene_biotype: protein_coding
description:
  Dynamin-related protein dnm1; Microtubule-associated force-producing protein that mediates mitochondrial fission during interphasic growth and at cell division. Fission of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. With vps1, acts redundantly in peroxisome biogenesis, which is under cell cycle control.


ensembl_gene_id: Q09749
symbol: izh2
gene_biotype: protein_coding
description:
  ADIPOR-like receptor SPBC12C2.09c; Probable receptor, which may be involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Belongs to the ADIPOR family.


ensembl_gene_id: Q09750
symbol: pst1
gene_biotype: protein_coding
description:
  Paired amphipathic helix protein pst1; Has a role in modulating the nuclear import of TF1 virus-like particles. Essential for viability.


ensembl_gene_id: Q09751
symbol: glo1
gene_biotype: protein_coding
description:
  Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.


ensembl_gene_id: Q09752
symbol: fnx1
gene_biotype: protein_coding
description:
  Multidrug resistance protein fnx1; Efflux transporter. Confers resistance to a variety of toxic compounds.


ensembl_gene_id: Q09755
symbol: SPAC24H6.10c
gene_biotype: protein_coding
description:
  Putative phospho-2-dehydro-3-deoxyheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP).


ensembl_gene_id: Q09756
symbol: hxk1
gene_biotype: protein_coding
description:
  Hexokinase-1; Catalyzes the phosphorylation of hexose (six-carbon sugars) to hexose 6-phosphate. Phosphorylates D-fructose, D-mannose and, to a lower extent, D-glucose. Compared to hxk2, has low affinity for D-glucose.


ensembl_gene_id: Q09760
symbol: cul3
gene_biotype: protein_coding
description:
  Cullin-3; Probable core component of multiple cullin-RING-based BC3B (BTB-CUL3-BTB) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the BC3B complex depends on the substrate recognition component (By similarity). Involved in ubiquitin-mediated degradation of btb3.


ensembl_gene_id: Q09761
symbol: sld3
gene_biotype: protein_coding
description:
  DNA replication regulator sld3; Required for loading and maintenance of stable association of cdc45 with chromatin during initiation and elongation of DNA replication. Also involved in temporal regulation of origin firing. Plays a role in meiosis.


ensembl_gene_id: Q09763
symbol: gef1
gene_biotype: protein_coding
description:
  Rho guanine nucleotide exchange factor gef1; Has a role in the control of cell polarity and cytokinesis. Involved in bipolar growth, via modulation of cdc42-shk1-orb6 signaling, and septum formation. Stimulates guanine nucleotide exchange of cdc42.


ensembl_gene_id: Q09765
symbol: uba3
gene_biotype: protein_coding
description:
  NEDD8-activating enzyme E1 catalytic subunit; Catalytic subunit of the dimeric uba3-ula1 E1 enzyme. E1 activates NEDD8/ubl1 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-uba3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of ubc12 (By similarity).


ensembl_gene_id: Q09766
symbol: SPAC24H6.13
gene_biotype: protein_coding
description:
  Uncharacterized membrane protein C24H6.13; Acts as an osmosensitive calcium-permeable cation channel. Belongs to the CSC1 (TC 1.A.17) family.


ensembl_gene_id: Q09767
symbol: alp41
gene_biotype: protein_coding
description:
  ADP-ribosylation factor-like protein alp41; Has a role in the cofactor-dependent pathway of microtubule biogenesis. Required for growth polarity control. Belongs to the small GTPase superfamily. Arf family.


ensembl_gene_id: Q09769
symbol: lon1
gene_biotype: protein_coding
description:
  Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family.


ensembl_gene_id: Q09770
symbol: SPAC1296.01c
gene_biotype: protein_coding
description:
  Phosphoacetylglucosamine mutase 2; Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, which is a biosynthetic precursor of chitin and also supplies the amino sugars for N-linked oligosaccharides of glycoproteins.


ensembl_gene_id: Q09772
symbol: rdh54
gene_biotype: protein_coding
description:
  Meiotic recombination protein rdh54; Acts with rhp54 to repair meiotic double strand breaks via homologous recombination. Involved in meiotic DNA recombination. Belongs to the SNF2/RAD54 helicase family.


ensembl_gene_id: Q09774
symbol: atp20
gene_biotype: protein_coding
description:
  ATP synthase subunit g, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the cent [...]


ensembl_gene_id: Q09775
symbol: rok1
gene_biotype: protein_coding
description:
  ATP-dependent RNA helicase rok1; ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.


ensembl_gene_id: Q09777
symbol: rgs1
gene_biotype: protein_coding
description:
  Regulator of G-protein signaling 1; Negatively regulates pheromone signaling during mating. Acts in a negative feedback loop that is essential for the mating process. This loop acts to down-regulate cellular sensitivity to pheromone. Activated by ste11.


ensembl_gene_id: Q09778
symbol: tsc1
gene_biotype: protein_coding
description:
  Tuberous sclerosis 1 protein homolog; Together with tsc2, required for uptake of various amino acids from the environment and for proper conjugation. Involved in induction of gene expression of permeases and genes required for meiosis upon nitrogen starvation. May act as a GTPase-activating protein (GAP) for the small GTPase rhb1.


ensembl_gene_id: Q09779
symbol: tho2
gene_biotype: protein_coding
description:
  THO complex subunit 2; Component the THO subcomplex of the TREX complex, which operates in coupling transcription elongation to mRNA export. The THO complex is recruited to transcribed genes and moves along the gene with the elongating polymerase during transcription. THO is important for stabilizing nascent RNA in the RNA polymerase II elongation complex by preventing formation of DNA:RNA hybrids behind the elongating polymerase.


ensembl_gene_id: Q09780
symbol: erg12
gene_biotype: protein_coding
description:
  Putative mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.


ensembl_gene_id: Q09782
symbol: gpi7
gene_biotype: protein_coding
description:
  GPI ethanolamine phosphate transferase 2; Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose (By similarity).


ensembl_gene_id: Q09783
symbol: tim8
gene_biotype: protein_coding
description:
  Mitochondrial import inner membrane translocase subunit tim8; Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIM8- TIM13 complex is non essential and only mediates  [...]


ensembl_gene_id: Q09785
symbol: gcv2
gene_biotype: protein_coding
description:
  Putative glycine dehydrogenase (decarboxylating), mitochondrial; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.


ensembl_gene_id: Q09790
symbol: aps1
gene_biotype: protein_coding
description:
  Diphosphoinositol polyphosphate phosphohydrolase aps1; Cleaves a beta-phosphate from the diphosphate groups in PP- InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate). Also catalyzes the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A.


ensembl_gene_id: Q09791
symbol: rcn1
gene_biotype: protein_coding
description:
  Uncharacterized protein C13G6.15c; Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin.


ensembl_gene_id: Q09793
symbol: nup45
gene_biotype: protein_coding
description:
  Nucleoporin nup45; Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope.


ensembl_gene_id: Q09794
symbol: ura1
gene_biotype: protein_coding
description:
  Glutamine-dependent carbamoyl-phosphate synthase; This protein is a 'fusion' protein encoding three enzymatic activities of the pyrimidine pathway (GATase, CPSase, and ATCase). In the central section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily.


ensembl_gene_id: Q09796
symbol: kap111
gene_biotype: protein_coding
description:
  Importin beta-like protein kap111; Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope; Belongs to the importin beta family.


ensembl_gene_id: Q09798
symbol: pan2
gene_biotype: protein_coding
description:
  PAN2-PAN3 deadenylation complex catalytic subunit pan2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein pab1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent  [...]


ensembl_gene_id: Q09799
symbol: kri1
gene_biotype: protein_coding
description:
  Protein kri1; Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA (By similarity); Belongs to the KRI1 family.


ensembl_gene_id: Q09801
symbol: iss1
gene_biotype: protein_coding
description:
  Pre-mRNA polyadenylation factor fip1; Pre-mRNA polyadenylation factor that directly interacts with poly(A) polymerase; Belongs to the FIP1 family.


ensembl_gene_id: Q09803
symbol: vps4
gene_biotype: protein_coding
description:
  Suppressor protein of bem1/bed5 double mutants; Involved in the transport of biosynthetic membrane proteins from the prevacuolar/endosomal compartment to the vacuole. Involved in multivesicular body (MVB) protein sorting. Catalyzes the ATP-dependent dissociation of class E VPS proteins from endosomal membranes, such as the disassembly of the ESCRT-III complex (By similarity).


ensembl_gene_id: Q09804
symbol: urb2
gene_biotype: protein_coding
description:
  Probable nucleolar pre-ribosomal-associated protein 2; Required for 27S pre-rRNA processing. Has an early role during 60S ribosomal subunit assembly (By similarity).


ensembl_gene_id: Q09805
symbol: vps45
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 45; Vacuolar protein sorting-associated protein involved in Golgi-to-vacuole protein transport.


ensembl_gene_id: Q09808
symbol: smn1
gene_biotype: protein_coding
description:
  Survival motor neuron-like protein 1; Has been implicated indirectly in general cellular RNA processing. Plays a crucial role in the generation of the pre-mRNA splicing machinery and in mRNA biogenesis by interacting with spliceosomal snRNPs.


ensembl_gene_id: Q09809
symbol: SPAC2G11.09
gene_biotype: protein_coding
description:
  Calcium permeable stress-gated cation channel 1; Acts as an osmosensitive calcium-permeable cation channel. Belongs to the CSC1 (TC 1.A.17) family.


ensembl_gene_id: Q09810
symbol: uba42
gene_biotype: protein_coding
description:
  Adenylyltransferase and sulfurtransferase uba4; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Acts by mediating the C-terminal thiocarboxylation of sulfur carrier URM1. Its N-terminus first activates URM1 as acyl-adenylate (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 to form thiocarboxylation (-COSH) of its C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1. Subseque [...]


ensembl_gene_id: Q09811
symbol: rqh1
gene_biotype: protein_coding
description:
  ATP-dependent DNA helicase hus2/rqh1; Has a role in the repair of UV-induced DNA damage in G2 via recombination-mediated repair. Also has a role in the repair of infrared-induced double DNA strand breaks. Exhibits an ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction; Belongs to the helicase family. RecQ subfamily.


ensembl_gene_id: Q09812
symbol: atg22
gene_biotype: protein_coding
description:
  Autophagy-related protein 22; Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation; Belongs to the ATG22 family.


ensembl_gene_id: Q09813
symbol: taf1
gene_biotype: protein_coding
description:
  Putative transcription initiation factor TFIID 111 kDa subunit; TAFs are components of the transcription factor IID (TFIID) complex that are essential for mediating regulation of RNA polymerase transcription.


ensembl_gene_id: Q09814
symbol: tgs1
gene_biotype: protein_coding
description:
  Trimethylguanosine synthase; Catalyzes the two serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Required for pre-mRNA splicing, pre-rRNA processing and small ribosomal subunit synthesis. Involved in nucleolar structural organization.


ensembl_gene_id: Q09815
symbol: pom2
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase ppk5; Has a role in meiosis; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.


ensembl_gene_id: Q09816
symbol: mta1
gene_biotype: protein_coding
description:
  S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.


ensembl_gene_id: Q09817
symbol: nmd3
gene_biotype: protein_coding
description:
  60S ribosomal export protein nmd3; Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.


ensembl_gene_id: Q09818
symbol: mot2
gene_biotype: protein_coding
description:
  Putative general negative regulator of transcription C16C9.04c; May negatively regulate the basal and activated transcription of many genes.


ensembl_gene_id: Q09820
symbol: upf1
gene_biotype: protein_coding
description:
  ATP-dependent helicase upf1; Required for rapid turnover of mRNAs containing a premature translational termination codon; Belongs to the DNA2/NAM7 helicase family.


ensembl_gene_id: Q09822
symbol: cdc15
gene_biotype: protein_coding
description:
  Cell division control protein 15; After the onset of mitosis, forms a ring-like structure which colocalizes with the medial actin ring. Appears to mediate cytoskeletal rearrangements required for cytokinesis. Essential for viability.


ensembl_gene_id: Q09823
symbol: rec10
gene_biotype: protein_coding
description:
  Meiotic recombination protein rec10; Involved primarily in the early steps of meiotic recombination localized to chromosome III.


ensembl_gene_id: Q09824
symbol: rep2
gene_biotype: protein_coding
description:
  Transcriptional activator protein rep2; Transcriptional activator which interacts with the mcb binding subunit complex formed by res2 and cdc10. Rep2 is required for the mitotic cell cycle start.


ensembl_gene_id: Q09825
symbol: sad1
gene_biotype: protein_coding
description:
  Spindle pole body-associated protein sad1; Associates with the spindle pole body and maintains a functional interface between the nuclear membrane and the microtubule motor proteins. Involved in chromosome segregation during meiosis where it associates with the telomeres.


ensembl_gene_id: Q09826
symbol: sds23
gene_biotype: protein_coding
description:
  Protein sds23/moc1; Required for normal DNA replication and for proper mitosis. Induces sexual development and ascus formation. Belongs to the SDS23 family.


ensembl_gene_id: Q09827
symbol: sss1
gene_biotype: protein_coding
description:
  Probable protein transport protein Sec61 subunit gamma; Necessary for protein translocation in the endoplasmic reticulum.


ensembl_gene_id: Q09828
symbol: SPAC4G8.09
gene_biotype: protein_coding
description:
  Putative leucine--tRNA ligase, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family.


ensembl_gene_id: Q09831
symbol: ppk14
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase ppk14; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. KIN82 subfamily.


ensembl_gene_id: Q09832
symbol: trm12
gene_biotype: protein_coding
description:
  tRNA wybutosine-synthesizing protein 2; S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S- adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86 (By similarity); Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.


ensembl_gene_id: Q09833
symbol: trm2
gene_biotype: protein_coding
description:
  tRNA (uracil(54)-C(5))-methyltransferase; Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNA. May also have a role in tRNA stabilization or maturation (By similarity); Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.


ensembl_gene_id: Q09835
symbol: gos1
gene_biotype: protein_coding
description:
  Protein transport protein gos1; Nonessential SNARE involved in retrograde transport within the Golgi complex.


ensembl_gene_id: Q09836
symbol: atp10
gene_biotype: protein_coding
description:
  Probable mitochondrial ATPase complex subunit atp10; Involved in assembly of the mitochondrial F1-F0 complex. Belongs to the ATP10 family.


ensembl_gene_id: Q09837
symbol: smp3
gene_biotype: protein_coding
description:
  GPI mannosyltransferase 4; Alpha-1,2-mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers a fourth mannose to trimannosyl-GPIs during GPI precursor assembly. The presence of a fourth mannose in GPI is essential in fungi (By similarity).


ensembl_gene_id: Q09838
symbol: prz1
gene_biotype: protein_coding
description:
  Transcriptional regulator prz1; Involved in the regulation of calcium ion homeostasis. Binds to the calcineurin-dependent response element. Transcriptionally regulates pmc1.


ensembl_gene_id: Q09841
symbol: pup1
gene_biotype: protein_coding
description:
  Probable proteasome subunit beta type-2; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (Potential); Belongs to the peptidase T1B family.


ensembl_gene_id: Q09842
symbol: pdp3
gene_biotype: protein_coding
description:
  PWWP domain-containing protein 3; Component of the mst2 complex which is a highly specific H3 lysine 14 (H3K14) acetyltransferase that functions together with gcn5 to regulate global levels of H3K14 acetylation (H3K14ac), critical for DNA damage checkpoint activation.


ensembl_gene_id: Q09843
symbol: rfc2
gene_biotype: protein_coding
description:
  Replication factor C subunit 2; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. Subunit 2 binds ATP and single-stranded DNA.


ensembl_gene_id: Q09845
symbol: gpd2
gene_biotype: protein_coding
description:
  Glycerol-3-phosphate dehydrogenase [NAD(+)] 2; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.


ensembl_gene_id: Q09847
symbol: nup146
gene_biotype: protein_coding
description:
  Nucleoporin nup146; Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope.


ensembl_gene_id: Q09848
symbol: usp108
gene_biotype: protein_coding
description:
  U1 snRNP-associated protein usp108; Component of the U1 snRNP particle, which recognizes and binds the 5'-splice site of pre-mRNA. Together with other non-snRNP factors, U1 snRNP forms the spliceosomal commitment complex, that targets pre-mRNA to the splicing pathway.


ensembl_gene_id: Q09849
symbol: arp42
gene_biotype: protein_coding
description:
  SWI/SNF and RSC complexes subunit arp42; Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. Controls particularly membrane and organelle development genes. Part of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing bindi [...]


ensembl_gene_id: Q09851
symbol: ayr1
gene_biotype: protein_coding
description:
  NADPH-dependent 1-acyldihydroxyacetone phosphate reductase; Can convert acyl and alkyl dihydroxyacetone-phosphate (DHAP) into glycerolipids and ether lipids, respectively. Required for the biosynthesis of phosphatidic acid via the DHAP pathway, where it reduces 1-acyl DHAP to lysophosphatidic acid (LPA). Required for spore germination (By similarity).


ensembl_gene_id: Q09852
symbol: pho842
gene_biotype: protein_coding
description:
  Putative inorganic phosphate transporter C23D3.12; High-affinity transporter for external inorganic phosphate. Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.


ensembl_gene_id: Q09853
symbol: SPAC23D3.13c
gene_biotype: protein_coding
description:
  Protein MON2 homolog; Required for traffic between late Golgi and early endosomes. Required for endocytosis and maintenance of vacuolar structure (By similarity).


ensembl_gene_id: Q09856
symbol: prp3
gene_biotype: protein_coding
description:
  U4/U5/U6 small nuclear ribonucleoprotein prp3; Participates in pre-mRNA splicing and in nuclear mRNA export. May play a role in the assembly of the U4/U5/U6 tri-snRNP complex.


ensembl_gene_id: Q09857
symbol: uso1
gene_biotype: protein_coding
description:
  Intracellular protein transport protein uso1; Required for protein transport from the ER to the Golgi complex; Belongs to the VDP/USO1/EDE1 family.


ensembl_gene_id: Q09858
symbol: nnf1
gene_biotype: protein_coding
description:
  Kinetochore protein nnf1; Acts as a component of the NMS (Ndc80-MIND-Spc7) super complex which has a role in kinetochore function during late meiotic prophase and throughout the mitotic cell cycle.


ensembl_gene_id: Q09859
symbol: mxr1
gene_biotype: protein_coding
description:
  Probable peptide methionine sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity).


ensembl_gene_id: Q09863
symbol: nst1
gene_biotype: protein_coding
description:
  Stress response protein nst1; May act as a negative regulator of salt tolerance. Belongs to the NST1 family.


ensembl_gene_id: Q09864
symbol: mcp60
gene_biotype: protein_coding
description:
  Heat shock protein 60, mitochondrial; May participate in assembly and/or disassembly of proteins imported into the mitochondrion. HSP60 are ATPases and have affinity for unfolded proteins; Belongs to the chaperonin (HSP60) family.


ensembl_gene_id: Q09868
symbol: cip2
gene_biotype: protein_coding
description:
  RNA-binding post-transcriptional regulator cip2; Regulates global gene expression after oxidative stress. Interacts and stabilizes mRNAs and may regulate their transition between different cytoplasmic components after oxidative stress.


ensembl_gene_id: Q09869
symbol: taf9
gene_biotype: protein_coding
description:
  Transcription initiation factor TFIID subunit 9; TAFs are components of the transcription factor IID (TFIID) complex that are essential for mediating regulation of RNA polymerase transcription.


ensembl_gene_id: Q09870
symbol: rcl1
gene_biotype: protein_coding
description:
  Probable RNA 3'-terminal phosphate cyclase-like protein; Does not have cyclase activity. Plays a role in 40S- ribosomal-subunit biogenesis in the early pre-rRNA processing steps at sites A0, A1 and A2 that are required for proper maturation of the 18S RNA (By similarity); Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.


ensembl_gene_id: Q09878
symbol: met10
gene_biotype: protein_coding
description:
  Probable sulfite reductase [NADPH] flavoprotein component; This enzyme catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate (By similarity).


ensembl_gene_id: Q09883
symbol: spn6
gene_biotype: protein_coding
description:
  Septin homolog spn6; Septin-like protein involved in the correct orientation of forespore membrane extension during sporulation.


ensembl_gene_id: Q09884
symbol: dcr1
gene_biotype: protein_coding
description:
  ATP-dependent helicase dcr1; Required for G1 arrest and mating in response to nitrogen starvation. Ago1 regulation of cytokinesis and cell cycle checkpoints occurs downstream of dcr1. Required, indirectly, for regulated hyperphosphorylation of cdc2.


ensembl_gene_id: Q09891
symbol: dnf2
gene_biotype: protein_coding
description:
  Putative phospholipid-transporting ATPase C24B11.12c; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.


ensembl_gene_id: Q09892
symbol: sty1
gene_biotype: protein_coding
description:
  Mitogen-activated protein kinase sty1; Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes. Involved in osmoregulation and stress response pathways leading to an efficient start of sexual differentiation. Supports translation initiation and facilitates adaptation to environmental stress in part through reducing eIF2-alpha phosphorylation. Links the cell-cycle G2/M control with changes in the extracellular environment that a [...]


ensembl_gene_id: Q09898
symbol: sid2
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase sid2; Part of a signaling pathway. Required for initiation of medial ring constriction and septation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.


ensembl_gene_id: Q09899
symbol: hem3
gene_biotype: protein_coding
description:
  Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.


ensembl_gene_id: Q09904
symbol: nup124
gene_biotype: protein_coding
description:
  Nucleoporin nup124; Nucleoporins may be involved in both binding and translocation of the proteins during nucleocytoplasmic transport. In S.pombe it is required for the nuclear localization of retrotransposon tf1.


ensembl_gene_id: Q09905
symbol: aps3
gene_biotype: protein_coding
description:
  AP-3 complex subunit sigma; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to the vacuole (By similarity).


ensembl_gene_id: Q09907
symbol: nth1
gene_biotype: protein_coding
description:
  Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. Has also 8-oxo-7,8- dihydroguanine (8-oxoG) DNA glycosylas [...]


ensembl_gene_id: Q09908
symbol: phf2
gene_biotype: protein_coding
description:
  SWM histone demethylase complex subunit phf2; Component of the SWM histone demethylase complex that specifically demethylates H3K9me2, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Has a role in regulating heterochromatin propagation and euchromatic transcription.


ensembl_gene_id: Q09909
symbol: cwf19
gene_biotype: protein_coding
description:
  Pre-mRNA-splicing factor cwf19; Involved in mRNA splicing where it associates with cdc5 and the other cwf proteins as part of the spliceosome; Belongs to the CWF19 family.


ensembl_gene_id: Q09912
symbol: psi1
gene_biotype: protein_coding
description:
  Protein psi1; Required for nuclear migration during mitosis. It is required for the normal initiation of translation.


ensembl_gene_id: Q09913
symbol: dal2
gene_biotype: protein_coding
description:
  Probable allantoicase; Utilization of purines as secondary nitrogen sources, when primary sources are limiting.


ensembl_gene_id: Q09914
symbol: rho1
gene_biotype: protein_coding
description:
  GTP-binding protein rho1; Involved in the regulation of cell wall growth and actin cytoskeleton organization. Activates (1,3)-beta-D-glucan synthase. Belongs to the small GTPase superfamily. Rho family.


ensembl_gene_id: Q09915
symbol: spt6
gene_biotype: protein_coding
description:
  Transcription elongation factor spt6; Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression (By similarity); Belongs to the SPT6 family.


ensembl_gene_id: Q09916
symbol: has1
gene_biotype: protein_coding
description:
  ATP-dependent RNA helicase has1; ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.


ensembl_gene_id: Q09917
symbol: pkd2
gene_biotype: protein_coding
description:
  TRP-like ion channel pkd2; Acts as a key signaling component in the regulation of cell shape and cell wall synthesis through interaction with GTPase Rho1.


ensembl_gene_id: Q09918
symbol: hsp3105
gene_biotype: protein_coding
description:
  Putative glutathione-independent glyoxalase hsp3105; May catalyze the conversion of methylglyoxal (MG) to D- lactate in a single glutathione (GSH)-independent step. May play a role in detoxifying endogenously produced glyoxals. Involved in protection against reactive oxygen species (ROS).


ensembl_gene_id: Q09919
symbol: fip1
gene_biotype: protein_coding
description:
  Plasma membrane iron permease; Permease for high affinity iron uptake. Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.


ensembl_gene_id: Q09920
symbol: fio1
gene_biotype: protein_coding
description:
  Iron transport multicopper oxidase fio1; Could be an iron transport multicopper oxidase, which is required for Fe(2+) high affinity uptake. May be required to oxidize Fe(2+) and release it from the transporter. Essential component of copper-dependent iron transport.


ensembl_gene_id: Q09924
symbol: tif224
gene_biotype: protein_coding
description:
  Probable translation initiation factor eIF-2B subunit delta; Catalyzes the exchange of eukaryotic initiation factor 2- bound GDP for GTP; Belongs to the eIF-2B alpha/beta/delta subunits family.


ensembl_gene_id: Q09925
symbol: lcb2
gene_biotype: protein_coding
description:
  Serine palmitoyltransferase 2; Catalytic subunit of serine palmitoyltransferase (SPT), which catalyzes the committed step in the synthesis of sphingolipids, the condensation of serine with palmitoyl CoA to form the long chain base 3-ketosphinganine; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.


ensembl_gene_id: Q09926
symbol: pcr1
gene_biotype: protein_coding
description:
  Transcription factor pcr1; Involved in regulation of gene expression for sexual development. Binds and activates meiotic recombination hot spot ade6- M26.


ensembl_gene_id: Q09927
symbol: aca1
gene_biotype: protein_coding
description:
  N-acetyltransferase aca1; N-acetyltransferase involved in oxidative stress resistance. Acetylates the toxic proline metabolism intermediate (S)-1-pyrroline-5- carboxylate (P5C), or more likely its spontaneously forming tautomer glutamate-5-semialdehyde (GSA) into N-acetyl-GSA for arginine synthesis in the mitochondria. P5C has been shown to increase the levels of reactive oxigen species (ROS) in the cell by inhibiting the function of the respiratory chain in the mitochondria. The enzyme is able to reduce intracellular ROS levels under P5C-induced oxidative stress and protects cells fro [...]


ensembl_gene_id: Q09928
symbol: cyp8
gene_biotype: protein_coding
description:
  Peptidyl-prolyl cis-trans isomerase cyp8; May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins. May also function as a chaperone, playing a role in intracellular transport of proteins. May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on proteins; Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.


ensembl_gene_id: Q09948
symbol: rsc4
gene_biotype: protein_coding
description:
  Chromatin structure-remodeling complex subunit rsc4; Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. Controls particularly membrane and organelle development genes.


ensembl_gene_id: Q0E7J8
symbol: rev7
gene_biotype: protein_coding
description:
  DNA polymerase zeta processivity subunit; Required for DNA damage induced mutagenesis. Involved in DNA repair, mitochondrial DNA repair and translesion synthesis. Has a role in the bypass of abasic (AP) sites (By similarity).


ensembl_gene_id: Q10055
symbol: fal1
gene_biotype: protein_coding
description:
  ATP-dependent RNA helicase fal1; ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA (By similarity). Belongs to the DEAD box helicase family. DDX48/FAL1 subfamily.


ensembl_gene_id: Q10056
symbol: shk2
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase shk2; Forms an activated complex with GTP-bound Ras-like cdc42. Participates in Ras-dependent morphological control and mating response pathways.


ensembl_gene_id: Q10057
symbol: pdi1
gene_biotype: protein_coding
description:
  Putative protein disulfide-isomerase C1F5.02; Participates in the folding of proteins containing disulfide bonds, may be involved in glycosylation, prolyl hydroxylation and triglyceride transfer.


ensembl_gene_id: Q10058
symbol: SPAC1F5.03c
gene_biotype: protein_coding
description:
  Putative oxidoreductase C1F5.03c; Putative oxidoreductase that negatively regulates the retrieval of cargo from late endosomes to the Golgi; Belongs to the TDA3 family.


ensembl_gene_id: Q10059
symbol: cdc12
gene_biotype: protein_coding
description:
  Cell division control protein 12; Plays a role in the cell cycle. Involved in cytokinesis. Component of the cell division ring. In the absence of profilin, caps the barbed end of actin filaments, thus preventing subunit addition and dissociation. In the presence of profilin, nucleates actin filaments that grow rapidly from their barbed ends. Belongs to the formin homology family. BNI1 subfamily.


ensembl_gene_id: Q10061
symbol: lsh1
gene_biotype: protein_coding
description:
  Heat shock protein 70 homolog lhs1; Chaperone required for protein translocation and folding in the endoplasmic reticulum.


ensembl_gene_id: Q10062
symbol: hem14
gene_biotype: protein_coding
description:
  Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.


ensembl_gene_id: Q10063
symbol: yam8
gene_biotype: protein_coding
description:
  Calcium influx-promoting protein ehs1; Required for Ca(2+) influx and for vitality of cells in a late, pheromone-induced event of the mating process requiring calcium- induced signaling; To yeast MID1.


ensembl_gene_id: Q10065
symbol: trk2
gene_biotype: protein_coding
description:
  Potassium transport protein 2; Together with TRK1, defines the major, high-affinity potassium influx transport system. Involved in maintenance of the proper sodium/potassium ratio in the cell and in regulating the plasma membrane potential.


ensembl_gene_id: Q10067
symbol: orc3
gene_biotype: protein_coding
description:
  Origin recognition complex subunit 3; Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. ORC binds to multiple sites within the ars1 origin of DNA replication in an ATP-independent manner.


ensembl_gene_id: Q10070
symbol: mdm31
gene_biotype: protein_coding
description:
  Mitochondrial distribution and morphology protein 31; Involved in the organization of the mitochondrial membranes and the global structure of the mitochondria. Also required for mitochondrial distribution and mobility as well as for the maintenance of mitochondrial DNA nucleoids structures (By similarity). Belongs to the MDM31/MDM32 family.


ensembl_gene_id: Q10071
symbol: ste24
gene_biotype: protein_coding
description:
  Probable CAAX prenyl protease 1; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family.


ensembl_gene_id: Q10074
symbol: avt3
gene_biotype: protein_coding
description:
  Vacuolar amino acid transporter 3; Involved in amino acid efflux from the vacuole to the cytoplasm. Capable of transporting large neutral amino acids including tyrosine, glutamine, asparagine, isoleucine and leucine (By similarity). Required for spore formation; Belongs to the amino acid/polyamine transporter 2 family.


ensembl_gene_id: Q10075
symbol: pcs2
gene_biotype: protein_coding
description:
  Glutathione gamma-glutamylcysteinyltransferase; Required for detoxification of heavy metals such as cadmium and arsenate.


ensembl_gene_id: Q10076
symbol: hsr1
gene_biotype: protein_coding
description:
  Hydrogen peroxide stress regulator 1; Transcription factor that globally supports gene expression in response to hydrogen peroxide.


ensembl_gene_id: Q10092
symbol: hsp3104
gene_biotype: protein_coding
description:
  Probable glutathione-independent glyoxalase hsp3104; Catalyzes the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step. May play a role in detoxifying endogenously produced glyoxals. Involved in protection against reactive oxygen species (ROS).


ensembl_gene_id: Q10099
symbol: seh1
gene_biotype: protein_coding
description:
  Nucleoporin seh1; Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope.


ensembl_gene_id: Q10100
symbol: nxt2
gene_biotype: protein_coding
description:
  Nuclear transport factor 2; Facilitates protein transport into the nucleus. Could be part of a multicomponent system of cytosolic factors that assemble at the pore complex during nuclear import (By similarity).


ensembl_gene_id: Q10103
symbol: chp1
gene_biotype: protein_coding
description:
  Chromo domain-containing protein 1; Component of the kinetochore which plays a role in stabilizing microtubules and so allowing accurate chromosome segregation. Has a role in the RNA interference (RNAi) pathway which is important for heterochromatin formation and accurate chromosome segregation. A member of the RNA-induced transcriptional silencing (RITS) complex which is involved in the biosynthesis of dsRNA from primer siRNAs provided by the RNA-directed RNA polymerase (RDRC) complex.


ensembl_gene_id: Q10104
symbol: shm2
gene_biotype: protein_coding
description:
  Serine hydroxymethyltransferase, mitochondrial; Interconversion of serine and glycine; Belongs to the SHMT family.


ensembl_gene_id: Q10105
symbol: gcn1
gene_biotype: protein_coding
description:
  eIF-2-alpha kinase activator gcn1; Acts as a positive activator of the gcn2 protein kinase activity in response to amino acid starvation. Component of the gcn1- gcn20 complex that forms a complex with gcn2 on translating ribosomes; during this process, gcn1 seems to act as a chaperone to facilitate delivery of uncharged tRNAs that enter the A site of ribosomes to the tRNA-binding domain of gcn2, and hence stimulating gcn2 kinase activity. Participates in the repression of global protein synthesis and in gene-specific mRNA translation activation, such as the transcriptional activator gc [...]


ensembl_gene_id: Q10106
symbol: utp11
gene_biotype: protein_coding
description:
  Probable U3 small nucleolar RNA-associated protein 11; Involved in nucleolar processing of pre-18S ribosomal RNA.


ensembl_gene_id: Q10107
symbol: mra1
gene_biotype: protein_coding
description:
  Ribosomal RNA small subunit methyltransferase mra1; S-adenosyl-L-methionine-dependent pseudouridine N(1)- methyltransferase that methylates the pseudouridine corresponding to position 1189 (Psi1189) in S.cerevisiae 18S rRNA. Involved the biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3- carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA. Has also an essential role in 40S ribosomal subunit biogenesis independent on its methyltransferase activity, facilitating the incorporation of ribosomal protein S19 during the formation of pre- ribosomes (By similarity [...]


ensembl_gene_id: Q10110
symbol: rrn3
gene_biotype: protein_coding
description:
  RNA polymerase I-specific transcription initiation factor rrn3; Required for efficient transcription initiation by RNA polymerase I; Belongs to the RRN3 family.


ensembl_gene_id: Q10113
symbol: mal3
gene_biotype: protein_coding
description:
  Microtubule integrity protein mal3; May play a role in regulating the integrity of microtubules possibly by influencing their stability. Involved in an anchoring mechanism to maintain tea2 and tip1 at growing microtubule ends. Strongly stimulates the ATPase activity of tea2. Belongs to the MAPRE family.


ensembl_gene_id: Q10132
symbol: idi1
gene_biotype: protein_coding
description:
  Isopentenyl-diphosphate Delta-isomerase; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).


ensembl_gene_id: Q10133
symbol: rho2
gene_biotype: protein_coding
description:
  GTP-binding protein rho2; Involved in cell morphogenesis, the maintenance of growth direction, control of polarity and of cell wall integrity. Regulates the synthesis of alpha-D-glucan through activation of pck2.


ensembl_gene_id: Q10134
symbol: fep1
gene_biotype: protein_coding
description:
  Iron-sensing transcription factor 1; Represses the expression of the iron transporter fio1 in response to high iron concentrations. Binds to the consensus sequence 5'-[AT]GATAA-3'. Also represses the expression of str1, str2 and str3.


ensembl_gene_id: Q10135
symbol: lsd2
gene_biotype: protein_coding
description:
  Lysine-specific histone demethylase 2; Catalytic component of the SWM histone demethylase complex that specifically demethylates H3K9me2, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Has a role in regulating heterochromatin propagation and euchromatic transcription. Also has a gene activating role; Belongs to the flavin monoamine oxidase family.


ensembl_gene_id: Q10136
symbol: ste7
gene_biotype: protein_coding
description:
  Protein ste7; Has a role in promoting meiosis whereby it is involved in establishing the mating pheromone signaling pathway. It also has a role in suppressing meiosis until the conjugation process is complete; Belongs to the arrestin family.


ensembl_gene_id: Q10137
symbol: spo20
gene_biotype: protein_coding
description:
  Sec14 cytosolic factor; Required for transport of secretory proteins from the Golgi complex. Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes in vitro. Essential for viability and secretion.


ensembl_gene_id: Q10139
symbol: img2
gene_biotype: protein_coding
description:
  54S ribosomal protein img2, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mL49 family.


ensembl_gene_id: Q10142
symbol: aur1
gene_biotype: protein_coding
description:
  Inositol phosphorylceramide synthase catalytic subunit aur1; Catalytic component of the inositol phosphorylceramide synthase which catalyzes the addition of a phosphorylinositol group onto ceramide to form inositol phosphorylceramide, an essential step in sphingolipid biosynthesis; Belongs to the AUR1 family.


ensembl_gene_id: Q10143
symbol: pfd3
gene_biotype: protein_coding
description:
  Probable prefoldin subunit 3; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity); Belongs to the prefoldin subunit alpha family.


ensembl_gene_id: Q10146
symbol: rrp6
gene_biotype: protein_coding
description:
  Exosome complex exonuclease rrp6; Nuclear-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export t [...]


ensembl_gene_id: Q10147
symbol: cct2
gene_biotype: protein_coding
description:
  Probable T-complex protein 1 subunit beta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity).


ensembl_gene_id: Q10148
symbol: tls1
gene_biotype: protein_coding
description:
  Telomere length and silencing protein 1; Involved in the regulation of heterochromatin assembly at telomeric regions. Involved in the control of telomere length. Regulates spliceosome assembly by associating with brr2. Regulates the proper splicing of mRNAs of the shelterin components rap1 and poz1 to control telomeric heterochromatin assembly and telomere length.


ensembl_gene_id: Q10150
symbol: aut12
gene_biotype: protein_coding
description:
  Vacuolar fusion protein mon1; Required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis; Belongs to the MON1/SAND family.


ensembl_gene_id: Q10153
symbol: pis1
gene_biotype: protein_coding
description:
  CDP-diacylglycerol--inositol 3-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.


ensembl_gene_id: Q10154
symbol: rtf2
gene_biotype: protein_coding
description:
  Replication termination factor 2; Replication termination factor which mediates replication termination at the site-specific replication barrier RTS1. Stabilizes the replication fork stalled at RTS1 until completion of DNA synthesis by a converging replication fork initiated at a flanking origin. Belongs to the rtf2 family.


ensembl_gene_id: Q10155
symbol: trz1
gene_biotype: protein_coding
description:
  Ribonuclease Z 1; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. May be involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. Belongs to the RNase Z family.


ensembl_gene_id: Q10156
symbol: lkh1
gene_biotype: protein_coding
description:
  Dual specificity protein kinase lkh1; Protein kinase that may act as a negative regulator of filamentous growth and flocculation. Appears to have a role in normal cell wall and septum formation and in cell separation. May have antagonistic function in the regulation of beta-glucan distribution between the sites for cell wall and septum assembly. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily.


ensembl_gene_id: Q10159
symbol: myh1
gene_biotype: protein_coding
description:
  Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. Has glycosylase and nicking activities and is active at A/G and A/GO sites.


ensembl_gene_id: Q10160
symbol: rmi1
gene_biotype: protein_coding
description:
  RecQ-mediated genome instability protein 1; Structure-specific DNA-binding protein with a preference for cruciform structures. Also binds single-stranded DNA (ssDNA). Functions together with top3 to maintain genome integrity. Essential for proper meiotic cell division. Required for normal S-phase progression and DNA damage response; Belongs to the RMI1 family.


ensembl_gene_id: Q10161
symbol: chc1
gene_biotype: protein_coding
description:
  Probable clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.


ensembl_gene_id: Q10162
symbol: bud23
gene_biotype: protein_coding
description:
  18S rRNA (guanine-N(7))-methyltransferase bud23; S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(7) position of a guanine in 18S rRNA. Important for biogenesis end export of the 40S ribosomal subunit independent on its methyltransferase activity (By similarity).


ensembl_gene_id: Q10163
symbol: smb1
gene_biotype: protein_coding
description:
  Small nuclear ribonucleoprotein-associated protein B; Involved in pre-mRNA splicing. Binds snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site (By similarity).


ensembl_gene_id: Q10165
symbol: cnt6
gene_biotype: protein_coding
description:
  Probable ribosylation factor GTPase-activating protein cnt6; GTPase-activating protein for the ADP ribosylation factor family.


ensembl_gene_id: Q10168
symbol: nsp1
gene_biotype: protein_coding
description:
  Nucleoporin nsp1; Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope. Appears to have a role in the formation of the septum.


ensembl_gene_id: Q10169
symbol: dsk2
gene_biotype: protein_coding
description:
  Deubiquitination-protection protein dph1; Protects ubiquitin chains against dissambly by deubiquitinating enzymes thereby promoting protein degradation.


ensembl_gene_id: Q10170
symbol: rmt2
gene_biotype: protein_coding
description:
  Protein arginine N-methyltransferase 2; S-adenosyl-L-methionine-dependent protein-arginine N- methyltransferase that methylates the delta-nitrogen atom of arginine residues to form N5-methylarginine (type IV) in target proteins. Monomethylates ribosomal protein L12.


ensembl_gene_id: Q10171
symbol: uch1
gene_biotype: protein_coding
description:
  Probable ubiquitin carboxyl-terminal hydrolase 1; Ubiquitin-protein hydrolase is involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin (By similarity). Belongs to the peptidase C12 family.


ensembl_gene_id: Q10172
symbol: pan1
gene_biotype: protein_coding
description:
  Actin cytoskeleton-regulatory complex protein pan1; Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).


ensembl_gene_id: Q10173
symbol: nuf2
gene_biotype: protein_coding
description:
  Kinetochore protein nuf2; Acts as a component of the NMS (Ndc80-MIND-Spc7) super complex which has a role in kinetochore function during late meiotic prophase and throughout the mitotic cell cycle. Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Belongs to the NUF2 family.


ensembl_gene_id: Q10175
symbol: ani2
gene_biotype: protein_coding
description:
  Probable peptidyl-prolyl cis-trans isomerase C27F1.06c; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity); Belongs to the FKBP-type PPIase family. FKBP3/4 subfamily.


ensembl_gene_id: Q10176
symbol: ost1
gene_biotype: protein_coding
description:
  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...]


ensembl_gene_id: Q10177
symbol: pdt1
gene_biotype: protein_coding
description:
  Manganese transporter pdt1; Transports manganese ions into the cell. Regulates cell morphogenesis through control of manganese homeostasis. Belongs to the NRAMP family.


ensembl_gene_id: Q10178
symbol: prp10
gene_biotype: protein_coding
description:
  U2 snRNP component prp10; Contacts pre-mRNA on both sides of the branch site early in spliceosome assembly; Belongs to the SF3B1 family.


ensembl_gene_id: Q10179
symbol: grs1
gene_biotype: protein_coding
description:
  Putative glycine--tRNA ligase; Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis.


ensembl_gene_id: Q10182
symbol: erf4
gene_biotype: protein_coding
description:
  Ras modification protein erf4; The erf2-erf4 complex is a palmitoyltransferase specific for Ras proteins. Palmitoylates RAS2, which is required for its proper plasma membrane localization (By similarity). Has a role in meiosis.


ensembl_gene_id: Q10185
symbol: abc2
gene_biotype: protein_coding
description:
  ATP-binding cassette transporter abc2; Involved in vacuolar sequestration of glutathione S- conjugates. Together with abc4, required for accumulation of a red pigment (ade pigment) in the vacuole of a mutant affected in the adenine biosynthetic pathway.


ensembl_gene_id: Q10189
symbol: spo12
gene_biotype: protein_coding
description:
  Mitosis-specific protein spo12; Has a role in controlling mitotic cell cycle progression at the G2/M transition phase.


ensembl_gene_id: Q10190
symbol: SPAC3F10.16c
gene_biotype: protein_coding
description:
  Large subunit GTPase 1; GTPase required for the nuclear export of the 60S ribosomal subunit. Acts by mediating the release of nmd3 from the 60S ribosomal subunit after export into the cytoplasm (By similarity).


ensembl_gene_id: Q10191
symbol: ltv1
gene_biotype: protein_coding
description:
  Protein LTV1; Involved in protein transport. Non-ribosomal factor required for efficient nuclear export of the ribosomal 40S subunit. May participate in intracellular sorting of GAP1 out of the endosome (By similarity); Belongs to the LTV1 family.


ensembl_gene_id: Q10193
symbol: srp1
gene_biotype: protein_coding
description:
  Pre-mRNA-splicing factor srp1; Has a role in pre-mRNA splicing where it is involved in spliceosome assembly.


ensembl_gene_id: Q10197
symbol: alp1
gene_biotype: protein_coding
description:
  Tubulin-folding cofactor D; Has a function in the folding of beta-tubulin. Microtubule- associated protein that is essential to direct polarized cell growth and to position the nucleus and septum to the center of the cell during mitosis.


ensembl_gene_id: Q10198
symbol: ndc80
gene_biotype: protein_coding
description:
  Kinetochore protein ndc80; Acts as a component of the NMS (Ndc80-MIND-Spc7) super complex which has a role in kinetochore function during late meiotic prophase and throughout the mitotic cell cycle. Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Belongs to the NDC80/HEC1 family.


ensembl_gene_id: Q10199
symbol: imp2
gene_biotype: protein_coding
description:
  Septation protein imp2; Required for normal septation. Involved in the disassembly of the medial ring during septation.


ensembl_gene_id: Q10202
symbol: dbp3
gene_biotype: protein_coding
description:
  ATP-dependent RNA helicase dbp3; ATP-dependent RNA helicase required for 60S ribosomal subunit synthesis. Involved in efficient pre-rRNA processing, predominantly at site A3, which is necessary for the normal formation of 25S and 5.8S rRNAs (By similarity); Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.


ensembl_gene_id: Q10204
symbol: acr1
gene_biotype: protein_coding
description:
  RNA polymerase I-specific transcription initiation factor RRN9 homolog; Component of the UAF (upstream activation factor) complex which interacts with the upstream element of the RNA polymerase I promoter and is required for the proper accumulation of rpa1/nuc1 at rDNAs. Required for nucleolar localization of condensin.


ensembl_gene_id: Q10205
symbol: rrp43
gene_biotype: protein_coding
description:
  Exosome complex component rrp43; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplas [...]


ensembl_gene_id: Q10206
symbol: dph2
gene_biotype: protein_coding
description:
  2-(3-amino-3-carboxypropyl)histidine synthase subunit 2; Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2. Belongs to the DPH1/DPH2 family. DPH2 subfamily.


ensembl_gene_id: Q10210
symbol: swc3
gene_biotype: protein_coding
description:
  SWR1 complex subunit swc3; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant H2A.Z leading to transcriptional regulation of selected genes by chromatin remodeling.


ensembl_gene_id: Q10213
symbol: srs2
gene_biotype: protein_coding
description:
  ATP-dependent DNA helicase srs2; ATP-dependent DNA helicase involved in DNA repair at least for UV-induced lesions. Also aids the recombinational repair of camptothecin-induced collapsed replication forks. Belongs to the helicase family. UvrD subfamily.


ensembl_gene_id: Q10215
symbol: rdl2
gene_biotype: protein_coding
description:
  Putative thiosulfate sulfurtransferase, mitochondrial; Thiosulfate sulfurtransferase which catalyzes the transfer of sulfane sulfur from thiosulfate to cyanide.


ensembl_gene_id: Q10216
symbol: SPAC4H3.08
gene_biotype: protein_coding
description:
  Uncharacterized oxidoreductase C4H3.08; Belongs to the short-chain dehydrogenases/reductases (SDR) family.


ensembl_gene_id: Q10217
symbol: SPAC4H3.09
gene_biotype: protein_coding
description:
  Putative acyl carrier protein, mitochondrial; Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity). May be involved in the synthesis of very- long-chain fatty acids; Belongs to the acyl carrier protein (ACP) family.


ensembl_gene_id: Q10220
symbol: pcc1
gene_biotype: protein_coding
description:
  EKC/KEOPS complex subunit SPAC4H3.13; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. SPAC4H3.13/PCC1 functions as a dimerization module for the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coacti [...]


ensembl_gene_id: Q10222
symbol: pta1
gene_biotype: protein_coding
description:
  mRNA cleavage and polyadenylation specificity factor complex subunit pta1; Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB.


ensembl_gene_id: Q10223
symbol: pof14
gene_biotype: protein_coding
description:
  F-box protein pof14; Expression is induced during oxidative stress. Plays an essential, SCF-independent, role in the stress response to hydrogen peroxide for survival, by negatively regulating ergosterol synthesis via direct binding to the squalene synthase erg9.


ensembl_gene_id: Q10224
symbol: trm9
gene_biotype: protein_coding
description:
  tRNA (carboxymethyluridine(34)-5-O)-methyltransferase; Required for the methylation of the wobble bases at position 34 in tRNA. Appears to have a role in stress-response (By similarity).


ensembl_gene_id: Q10225
symbol: btb3
gene_biotype: protein_coding
description:
  BTB/POZ domain-containing protein 3; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.


ensembl_gene_id: Q10231
symbol: erg7
gene_biotype: protein_coding
description:
  Lanosterol synthase; Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus.


ensembl_gene_id: Q10233
symbol: rpc2
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerase III subunit RPC2; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the clef [...]


ensembl_gene_id: Q10235
symbol: alp11
gene_biotype: protein_coding
description:
  Cell polarity protein alp11; Required for microtubule function and cell polarity. Involved in the proper folding of alpha-tubulin.


ensembl_gene_id: Q10236
symbol: rnh201
gene_biotype: protein_coding
description:
  Ribonuclease H2 subunit A; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. Participates in DNA replication.


ensembl_gene_id: Q10239
symbol: chz1
gene_biotype: protein_coding
description:
  Histone H2A.Z-specific chaperone chz1; Forms a chaperone-bound H2A.Z-H2B complex that acts as a source for SWR1 complex-dependent H2A to H2A.Z histone replacement in chromatin.


ensembl_gene_id: Q10241
symbol: cmb1
gene_biotype: protein_coding
description:
  Mismatch-binding protein cmb1; Binds to cytosines in base mismatches and opposite chemically altered guanines.


ensembl_gene_id: Q10243
symbol: vps26
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 26; Plays a role in vesicular protein sorting. Required for the endosome-to-Golgi retrieval of the vacuolar protein sorting receptor pep1/vps10. Component of the membrane-associated retromer complex which is essential in endosome-to-Golgi retrograde transport. The vps29- vps26-vps35 subcomplex may be involved in cargo selection.


ensembl_gene_id: Q10245
symbol: ifa38
gene_biotype: protein_coding
description:
  Very-long-chain 3-oxoacyl-CoA reductase; Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3- ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids. Belongs to the short-chain dehydrogenases/reductases (SDR) family.


ensembl_gene_id: Q10251
symbol: tif52
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 5B; Plays a role in translation initiation. Translational GTPase that catalyzes the joining of the 40S and 60S subunits to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon. GTP binding and hydrolysis induces conformational changes in the enzyme that renders it active for productive interactions with the ribosome. The release of the enzyme after formation of the initiation complex is a prerequisite to form elongation-competent ribosomes; Belongs to the TRAFAC class translation factor  [...]


ensembl_gene_id: Q10252
symbol: ppt1
gene_biotype: protein_coding
description:
  4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate; Belongs to the UbiA prenyltransferase family.


ensembl_gene_id: Q10254
symbol: alg10
gene_biotype: protein_coding
description:
  Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase; Adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol; Belongs to the ALG10 glucosyltransferase family.


ensembl_gene_id: Q10256
symbol: mud1
gene_biotype: protein_coding
description:
  UBA domain-containing protein Mud1; Recognizes and binds polyubiquitin chains. Acts as a linker between the 19S proteasome and polyubiquitinated proteins via UBA domain interactions with ubiquitin for their subsequent degradation. Aspartic protease. Appears to act as negative regulator of constitutive exocytosis. May act at the level of secretory vesicle docking and fusion as a competitive inhibitor of SNARE assembly. Required for S-phase checkpoint control (By similarity); Belongs to the DDI1 family.


ensembl_gene_id: Q10257
symbol: rrp8
gene_biotype: protein_coding
description:
  25S rRNA (adenine(645)-N(1))-methyltransferase; S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of adenine in helix 25.1 in 25S rRNA. Required both for ribosomal 40S and 60S subunits biogenesis. Required for efficient pre-rRNA cleavage at site A2 (By similarity).


ensembl_gene_id: Q10258
symbol: met9
gene_biotype: protein_coding
description:
  Methylenetetrahydrofolate reductase 1; Major methylenetetrahydrofolate reductase required to generate the methyl groups necessary for methionine synthetase to convert homocysteine to methionine. Performs 80 to 85 percent of the total methylenetetrahydrofolate reductase activity of the cells.


ensembl_gene_id: Q10259
symbol: spc3
gene_biotype: protein_coding
description:
  Probable microsomal signal peptidase subunit 3; Microsomal signal peptidase is a membrane-bound endoproteinase that removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Belongs to the SPCS3 family.


ensembl_gene_id: Q10264
symbol: pso2
gene_biotype: protein_coding
description:
  DNA cross-link repair protein pso2/snm1; Required for DNA interstrand cross-link repair. This requires cleavage of cross-linked DNA to generate DNA double strand breaks (DSBs). This protein may have 5' exonuclease activity on single- stranded and double-stranded DNA, which could be necessary for the processing of DNA double strand breaks prior to religation.


ensembl_gene_id: Q10267
symbol: upf3
gene_biotype: protein_coding
description:
  Nonsense-mediated mRNA decay protein 3; Involved in nonsense-mediated decay of mRNAs containing premature stop codons; Belongs to the RENT3 family.


ensembl_gene_id: Q10268
symbol: mac1
gene_biotype: protein_coding
description:
  Membrane-anchored protein 1; Required for correct cell separation at high temperatures; To yeast YOL019W and YMR063W.


ensembl_gene_id: Q10270
symbol: met16
gene_biotype: protein_coding
description:
  Probable phosphoadenosine phosphosulfate reductase; The NADP dependent reduction of PAPS into sulfite involves thioredoxin which probably plays the role of a thiol carrier (By similarity). Required for methionine synthesis.


ensembl_gene_id: Q10271
symbol: arb2
gene_biotype: protein_coding
description:
  Argonaute-binding protein 2; A member of the argonaute siRNA chaperone (ARC) complex which is required for histone H3K9 methylation, heterochromatin assembly and siRNA generation. The ARC complex contains mostly double-stranded siRNA. Inhibits the release of the siRNA passenger strand from ago1 together with arb1.


ensembl_gene_id: Q10272
symbol: crb3
gene_biotype: protein_coding
description:
  Pre-rRNA-processing protein crb3/ipi3; Required for both pre-rRNA processing and heterochromatic gene silencing; Belongs to the WD repeat IPI3/WDR18 family.


ensembl_gene_id: Q10274
symbol: teb1
gene_biotype: protein_coding
description:
  Telobox protein 1; General transcription factor with prominent roles in controlling histone levels and stability. Binds and regulates the activities of many promoters, including those controlling the expression of all four types of canonical histones. Is also involved in the centromeric loading of cnp1 and maintenance of centromere identity. Moreover, regulates the expression of cdc2, a protease capable of histone clipping.


ensembl_gene_id: Q10277
symbol: msa1
gene_biotype: protein_coding
description:
  Multicopy suppressor of sporulation protein msa1; Negative regulator of sexual differentiation. Acts by repressing the transcription of meiosis-inducing, ste11-regulated genes.


ensembl_gene_id: Q10281
symbol: cpc2
gene_biotype: protein_coding
description:
  Guanine nucleotide-binding protein subunit beta-like protein; May be a receptor for protein kinase C in the regulation of actin cytoskeleton organization during cell wall synthesis and morphogenesis; Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.


ensembl_gene_id: Q10282
symbol: git5
gene_biotype: protein_coding
description:
  Guanine nucleotide-binding protein subunit beta; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Required for adenylate cyclase activation.


ensembl_gene_id: Q10283
symbol: hmg1
gene_biotype: protein_coding
description:
  3-hydroxy-3-methylglutaryl-coenzyme A reductase; Catalyzes the conversion of HMG-CoA to mevalonate. It is the rate-limiting enzyme of the sterol biosynthesis pathway. Involved in ergosterol biosynthesis.


ensembl_gene_id: Q10284
symbol: sks2
gene_biotype: protein_coding
description:
  Ribosome-associated molecular chaperone sks2; Ribosome-bound, Hsp70-type chaperone that assists in the cotranslational folding of newly synthesized proteins in the cytosol. Stimulates folding by interacting with nascent chains, binding to short, largely hydrophobic sequences exposed by unfolded proteins, thereby stabilizing longer, more slowly translated, and aggregation- prone nascent polypeptides and domains that cannot fold stably until fully synthesized. The Hsp70-protein substrate interaction depends on ATP-binding and on allosteric regulation between the NBD and the SBD. The ATP- [...]


ensembl_gene_id: Q10287
symbol: bgs1
gene_biotype: protein_coding
description:
  1,3-beta-glucan synthase component bgs1; Required for the assembly of the division septum and maintenance of cell polarity.


ensembl_gene_id: Q10289
symbol: fas2
gene_biotype: protein_coding
description:
  3-oxoacyl-[acyl-carrier-protein] reductase; Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The alpha subunit contains domains for: acyl carrier protein, 3-oxoacyl-[acyl-carrier- protein] reductase, and 3-oxoacyl-[acyl-carrier-protein] synthase. This subunit coordinates the binding of the six beta subunits to the enzyme complex.


ensembl_gene_id: Q10290
symbol: mal2
gene_biotype: protein_coding
description:
  Inner kinetochore subunit mal2; Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore COMA complex, which connects centromere-associated proteins and the outer kinetochore. COMA interacts with other inner kinetochore proteins to form the inner kinetochore constitutive centromere- associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.


ensembl_gene_id: Q10292
symbol: mek1
gene_biotype: protein_coding
description:
  Meiosis-specific serine/threonine-protein kinase mek1; Probable protein kinase required for meiotic recombination.


ensembl_gene_id: Q10294
symbol: pac2
gene_biotype: protein_coding
description:
  cAMP-independent regulatory protein pac2; Controls the onset of sexual development, by inhibiting the expression of ste11, in a pathway that is independent of the cAMP cascade.


ensembl_gene_id: Q10295
symbol: pla1
gene_biotype: protein_coding
description:
  Poly(A) polymerase pla1; Polymerase that creates the 3'-poly(A) tail of mRNA's. May acquire specificity through interaction with a cleavage and polyadenylation factor (CF I).


ensembl_gene_id: Q10297
symbol: kap114
gene_biotype: protein_coding
description:
  Importin subunit beta-5; Required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins. Serves a receptor for nuclear localization signals. Mediates the nuclear import of TATA- binding protein (TBP) and of histones H2A and H2B (By similarity).


ensembl_gene_id: Q10299
symbol: SPAC22H10.05c
gene_biotype: protein_coding
description:
  mRNA cleavage and polyadenylation factor clp1; Required for endonucleolytic cleavage during polyadenylation- dependent pre-mRNA 3'-end formation.


ensembl_gene_id: Q10303
symbol: alp21
gene_biotype: protein_coding
description:
  Cell polarity protein alp21; Required for microtubule and spindle assembly. Involved in the proper folding of alpha-tubulin.


ensembl_gene_id: Q10309
symbol: neo1
gene_biotype: protein_coding
description:
  Putative phospholipid-transporting ATPase C6C3.06c; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.


ensembl_gene_id: Q10313
symbol: trl1
gene_biotype: protein_coding
description:
  tRNA ligase 1; Required for the splicing of precursor tRNA molecules containing introns. The ligation activity requires three enzymatic activities: phosphorylation of the 5' terminus of the 3' half-tRNA in the presence of ATP, opening of the 2'3'-cyclic phosphodiester bond of the 5' half-tRNA leaving a 2'-phosphomonoester and ligation of the two tRNA halves in an ATP-dependent reaction; Belongs to the TRL1 family.


ensembl_gene_id: Q10315
symbol: bur6
gene_biotype: protein_coding
description:
  Transcription regulator complex subunit bur6; Transcription regulator complex subunit that is essential for cell cycle progression.


ensembl_gene_id: Q10316
symbol: arc5
gene_biotype: protein_coding
description:
  Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.


ensembl_gene_id: Q10317
symbol: med20
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 20; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general  [...]


ensembl_gene_id: Q10319
symbol: yaf9
gene_biotype: protein_coding
description:
  Protein AF-9 homolog; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4 and H2A. The NuA4 complex is also involved in DNA repair. Yaf9 may also be required for viability in conditions in which the structural integrity of the spindle is compromised (By similarity).


ensembl_gene_id: Q10322
symbol: dma1
gene_biotype: protein_coding
description:
  Probable E3 ubiquitin-protein ligase dma1; Probable E3 ubiquitin-protein ligase which is a component of the spindle assembly checkpoint, required to prevent septum formation and premature exit from mitosis if spindle function is compromised. Inhibits the septation initiation netwok (SIN) during spindle checkpoint activation. The effect appears to be mediated through preventing the SIN activator, plo1 kinase, from localizing to the SPB. Belongs to the DMA1 family.


ensembl_gene_id: Q10323
symbol: imt3
gene_biotype: protein_coding
description:
  Inositol phosphoceramide mannosyltransferase 3; With imt1 and imt2, is required for the synthesis of mannosylinositol phosphoceramide (MIPC). Catalyzes the addition of mannosyl to inositol phosphoceramide (IPC). MIPC is essential for cell morphology, cell-surface distribution of ergosterol, localization for plasma-membrane transporters, and lipid-raft-mediated endocytosis of plasma membrane proteins to the vacuole; Belongs to the glycosyltransferase 32 family.


ensembl_gene_id: Q10325
symbol: mst2
gene_biotype: protein_coding
description:
  Histone acetyltransferase mst2; Component of the mst2 complex which is a highly specific H3 lysine 14 (H3K14) acetyltransferase that functions together with gcn5 to regulate global levels of H3K14 acetylation (H3K14ac), critical for DNA damage checkpoint activation. Negatively regulates telomere silencing. Telomere silencing is increased due to histone hypoacetylation and/or an increase in the ratio of methylated histones to acetylated histones. Telomeric histone acetylation contributes to normal meiotic progression.


ensembl_gene_id: Q10328
symbol: phx1
gene_biotype: protein_coding
description:
  Homeobox transcription factor phx1; Trnascription factor that regulates the expression of the homocitrate synthase (HCS) lys4.


ensembl_gene_id: Q10329
symbol: pre6
gene_biotype: protein_coding
description:
  Probable proteasome subunit alpha type-4; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity); Belongs to the peptidase T1A family.


ensembl_gene_id: Q10330
symbol: rpl2501
gene_biotype: protein_coding
description:
  60S ribosomal protein L25-A; This protein binds to a specific region on the 26S rRNA. Belongs to the universal ribosomal protein uL23 family.


ensembl_gene_id: Q10331
symbol: nup107
gene_biotype: protein_coding
description:
  Nucleoporin nup107; Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope.


ensembl_gene_id: Q10333
symbol: pex11
gene_biotype: protein_coding
description:
  Peroxisomal biogenesis factor 11; Involved in peroxisomal proliferation. Promotes peroxisome division and biogenesis (By similarity); Belongs to the peroxin-11 family.


ensembl_gene_id: Q10335
symbol: rpn7
gene_biotype: protein_coding
description:
  Probable 26S proteasome regulatory subunit rpn7; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.


ensembl_gene_id: Q10336
symbol: mcp6
gene_biotype: protein_coding
description:
  Meiotic coiled-coil protein 6; Has a role in meiotic nuclear oscillation and recombination. Required to remodel astral microtubules into the 'horsetail' astral array maintaining the 'horsetail' nuclear movement. Promotes homologous paring of chromosomes during this movement.


ensembl_gene_id: Q10337
symbol: brc1
gene_biotype: protein_coding
description:
  BRCT-containing protein 1; Required for mitotic fidelity, specifically in the G2 phase of the cell cycle. Plays a role in chromatin organization.


ensembl_gene_id: Q10341
symbol: cys2
gene_biotype: protein_coding
description:
  Serine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L-serine, forming succinyl-L-serine. Has also weak serine acetyl transferase activity and homoserine succinyl transferase activity.


ensembl_gene_id: Q10342
symbol: sda1
gene_biotype: protein_coding
description:
  Protein sda1; Required for 60S pre-ribosomal subunits export to the cytoplasm. May also be required for 60S ribosomal subunit maturation and accumulation (By similarity); Belongs to the SDA1 family.


ensembl_gene_id: Q10343
symbol: cbs2
gene_biotype: protein_coding
description:
  5'-AMP-activated protein kinase subunit gamma; Adenine nucleotides-binding subunit gamma of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer- term effects via phosphorylation of transcription regulators [...]


ensembl_gene_id: Q10344
symbol: tma19
gene_biotype: protein_coding
description:
  Translationally-controlled tumor protein homolog; Involved in calcium binding and microtubule stabilization (By similarity). May be a guanine nucleotide-free chaperone (GFC). Belongs to the TCTP family.


ensembl_gene_id: Q10349
symbol: ser1
gene_biotype: protein_coding
description:
  Putative phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine.


ensembl_gene_id: Q10351
symbol: gpi17
gene_biotype: protein_coding
description:
  GPI transamidase component PIG-S homolog; Component of the GPI transamidase complex. Involved in transfer of GPI to proteins (By similarity); Belongs to the PIGS family.


ensembl_gene_id: Q10353
symbol: rlp24
gene_biotype: protein_coding
description:
  Ribosome biogenesis protein rlp24; Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of nog1 to pre-60S particles. Activates and recruits ATPase afg2 to cytoplasmic pre-60S ribosomal particles.


ensembl_gene_id: Q10356
symbol: sdj1
gene_biotype: protein_coding
description:
  Glutathione-independent glyoxalase DJ-1; Catalyzes the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step. May play a role in detoxifying endogenously produced glyoxals. Involved in protection against reactive oxygen species (ROS) (By similarity). Belongs to the peptidase C56 family.


ensembl_gene_id: Q10357
symbol: ccs1
gene_biotype: protein_coding
description:
  Superoxide dismutase 1 copper chaperone; Copper chaperone for superoxide dismutase 1 (sod1). Binds copper ions and delivers them specifically to sod1. Also has a role in cell protection against copper ion toxicity during conditions of copper excess. The C-terminal region is thought to act specifically in this sequestration role; Belongs to the CCS1 family.


ensembl_gene_id: Q10359
symbol: gmh3
gene_biotype: protein_coding
description:
  Alpha-1,2-galactosyltransferase gmh3; Involved in the galactosylation of the N-linked core oligosaccharide Man(9)GlcNAc(2); Belongs to the glycosyltransferase 34 family.


ensembl_gene_id: Q10360
symbol: rrn10
gene_biotype: protein_coding
description:
  RNA polymerase I-specific transcription initiation factor rrn10; Component of the UAF (upstream activation factor) complex which interacts with the upstream element of the RNA polymerase I promoter and forms a stable preinitiation complex. UAF seems to stimulate basal transcription to a fully activated level.


ensembl_gene_id: Q10362
symbol: set3
gene_biotype: protein_coding
description:
  SET domain-containing protein 3; Transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. Required for both gene activation and repression. Part of the Set3C complex, which is required to repress early/middle sporulation genes during meiosis. Required for the transcriptional activation of genes with high activity (By similarity); Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET3 subfamily.


ensembl_gene_id: Q10364
symbol: sck2
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase sck2; Protein kinase that is part of growth control pathway which is at least partially redundant with the cAMP pathway.


ensembl_gene_id: Q10366
symbol: pik1
gene_biotype: protein_coding
description:
  Phosphatidylinositol 4-kinase pik1; Acts on phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol 1,4,5,- trisphosphate. PIK1 is part of a nuclear phosphoinositide cycle and could control cytokinesis through the actin cytoskeleton (By similarity); Belongs to the PI3/PI4-kinase family.


ensembl_gene_id: Q10367
symbol: glo3
gene_biotype: protein_coding
description:
  ADP-ribosylation factor GTPase-activating protein glo3; GTPase-activating protein for the ADP ribosylation factor (ARF) family. Involved in retrograde vesicular transport from the Golgi to the endoplasmic reticulum (By similarity).


ensembl_gene_id: Q10407
symbol: mkh1
gene_biotype: protein_coding
description:
  MAP kinase kinase kinase mkh1; May regulate cell morphology, cell wall integrity, salt resistance, cell cycle reentry from stationary-phase arrest, and filamentous growth in response to stress. Activates the MAP kinase kinase skh1/pek1 by phosphorylation.


ensembl_gene_id: Q10409
symbol: tsr3
gene_biotype: protein_coding
description:
  Ribosome biogenesis protein tsr3; Ribosome biogenesis protein required for processing 35S pre- rRNA at site D; Belongs to the TSR3 family.


ensembl_gene_id: Q10410
symbol: gga21
gene_biotype: protein_coding
description:
  Probable ADP-ribosylation factor-binding protein C1F3.05; May play a role in the regulation of membrane traffic through the trans-Golgi network.


ensembl_gene_id: Q10412
symbol: rsc58
gene_biotype: protein_coding
description:
  Chromatin structure-remodeling complex subunit rsc58; Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. Controls particularly membrane and organelle development genes.


ensembl_gene_id: Q10415
symbol: oct1
gene_biotype: protein_coding
description:
  Mitochondrial intermediate peptidase; Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity).


ensembl_gene_id: Q10423
symbol: cce1
gene_biotype: protein_coding
description:
  Cruciform cutting endonuclease 1, mitochondrial; Capable of resolving Holliday junctions. Specific for 4-way junctions. Seems to be important for the maintenance of mitochondrial DNA. Cleaves fixed junctions at the point of strand exchange. Cleaves after 5'-CT-3' and 5'-TT-3' sequences.


ensembl_gene_id: Q10424
symbol: zip1
gene_biotype: protein_coding
description:
  Transcription factor zip1; Mediates cell growth arrest in response to cadmium exposure, which is essential to maintain cell viability. Regulates cadmium stress specific genes; Belongs to the bZIP family.


ensembl_gene_id: Q10425
symbol: tif302
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 3 subunit B; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.


ensembl_gene_id: Q10426
symbol: rik1
gene_biotype: protein_coding
description:
  Chromatin modification-related protein rik1; Component of the rik1-associated E3 ubiquitin ligase complex that shows ubiquitin ligase activity and is required for histone H3K9 methylation. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting swi6/HP1 to methylated histones which leads to transcriptional silencing within centromeric heterochromatin, telomeric regions and at the silent mating-type loci. Rik1 has also a function in meiotic telomere clustering.


ensembl_gene_id: Q10428
symbol: par1
gene_biotype: protein_coding
description:
  Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta 1 isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Has a role in cell shape control and septum formation.


ensembl_gene_id: Q10429
symbol: cnd3
gene_biotype: protein_coding
description:
  Condensin complex subunit 3; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. The condensin complex probably also plays a role during interphase; Belongs to the CND3 (condensin subunit 3) family.


ensembl_gene_id: Q10430
symbol: spc25
gene_biotype: protein_coding
description:
  Kinetochore protein spc25; Acts as a component of the NMS (Ndc80-MIND-Spc7) super complex which has a role in kinetochore function during late meiotic prophase and throughout the mitotic cell cycle. Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.


ensembl_gene_id: Q10432
symbol: ccq1
gene_biotype: protein_coding
description:
  Coiled-coil quantitatively-enriched protein 1; Component of the meiotic bouquet that facilitates meiotic nuclear reorganization of the telomeres to the centrosome. Links telomeres to the meiotic centrosome component pcp1. Essential for the formation of normal telomere clusters during meiotic prophase. Required for telomere length regulation and chromosome segregation. Required for proper positioning of nucleosomes at heterochromatic loci and for transcriptional gene silencing (TGS) function of the Snf2/Hdac- containing repressor complex (SHREC).


ensembl_gene_id: Q10434
symbol: acp1
gene_biotype: protein_coding
description:
  F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Competes with formin cdc12 for attachment to the actin filaments barbed ends. Slowly replaces cdc12 on the barbed ends in preparation for filament disassembly during contractile ring constriction.


ensembl_gene_id: Q10435
symbol: SPAC12B10.01c
gene_biotype: protein_coding
description:
  Probable ubiquitin fusion degradation protein C12B10.01c; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.


ensembl_gene_id: Q10437
symbol: bun62
gene_biotype: protein_coding
description:
  UBP9-binding protein bun62; Required for the ubp9 recruitment to septa and cell tips but also for its enzymatic activity at these specific locations.


ensembl_gene_id: Q10439
symbol: icp55
gene_biotype: protein_coding
description:
  Intermediate cleaving peptidase 55; Aminopeptidase which cleaves preprotein intermediates that carry destabilizing N-ter amino acid residues after the mitochondrial processing peptidase (MPP) cleavage site and is thus critical for stabilization of the mitochondrial proteome.


ensembl_gene_id: Q10440
symbol: emi5
gene_biotype: protein_coding
description:
  Succinate dehydrogenase assembly factor 2, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer.


ensembl_gene_id: Q10441
symbol: til1
gene_biotype: protein_coding
description:
  Probable tRNA(Ile)-lysidine synthase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity); Belongs to the tRNA(Ile)-lysidine synthase family.


ensembl_gene_id: Q10445
symbol: rhp41
gene_biotype: protein_coding
description:
  DNA repair protein rhp41; Has a role in the nucleotide excision repair (NER) pathway. Acts in both transcription-coupled repair (TCR) which removes damage from the transcribed strand of active genes and in global genome repair (GGR) which removes damage in untranscribed DNA. Involved in the repair of UV-induced damages where it is involved in the removal of cyclobutane pyrimidine dimers (CPDs); Belongs to the XPC family.


ensembl_gene_id: Q10451
symbol: ppr5
gene_biotype: protein_coding
description:
  Pentatricopeptide repeat-containing protein 5, mitochondrial; Mitochondrial RNA-binding protein that acts as a general negative regulator of mitochondrial translation.


ensembl_gene_id: Q10452
symbol: gsk3
gene_biotype: protein_coding
description:
  Protein kinase gsk3; Interacts with cdc14 which is thought to play a role in the initiation and completion of mitosis. Involved in the positive regulation of mis12.


ensembl_gene_id: Q10474
symbol: lys7
gene_biotype: protein_coding
description:
  L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase; Catalyzes the transfer of a 4'-phosphopantetheine moiety from coenzyme A to a serine residue of acceptor proteins, such as alpha- aminoadipate reductase. Necessary for alpha-aminoadipate reductase activity.


ensembl_gene_id: Q10475
symbol: tif471
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 4 gamma; Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. Belongs to the eukaryotic initiation factor 4G family.


ensembl_gene_id: Q10477
symbol: pmc3
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 27; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.


ensembl_gene_id: Q10478
symbol: sam50
gene_biotype: protein_coding
description:
  SAM50-like protein SPAC17C9.06; May be required for the assembly pathway of mitochondrial outer membrane proteins; Belongs to the SAM50/omp85 family.


ensembl_gene_id: Q10479
symbol: alg8
gene_biotype: protein_coding
description:
  Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase; Adds the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol (By similarity). Belongs to the ALG6/ALG8 glucosyltransferase family.


ensembl_gene_id: Q10480
symbol: pnu1
gene_biotype: protein_coding
description:
  Nuclease 1, mitochondrial; This enzyme has both RNase and DNase activity. It degrades single-stranded DNA and RNA.


ensembl_gene_id: Q10481
symbol: tim13
gene_biotype: protein_coding
description:
  Mitochondrial import inner membrane translocase subunit tim13; Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIM8- TIM13 complex is non essential and only mediates [...]


ensembl_gene_id: Q10488
symbol: etr1
gene_biotype: protein_coding
description:
  Enoyl-[acyl-carrier-protein] reductase, mitochondrial; Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. Required for respiration and the maintenance of the mitochondrial compartment. Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.


ensembl_gene_id: Q10489
symbol: pda1
gene_biotype: protein_coding
description:
  Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).


ensembl_gene_id: Q10490
symbol: lrs1
gene_biotype: protein_coding
description:
  Putative leucine--tRNA ligase, cytoplasmic; Belongs to the class-I aminoacyl-tRNA synthetase family.


ensembl_gene_id: Q10491
symbol: sec74
gene_biotype: protein_coding
description:
  Arf guanine nucleotide exchange factor sec74; Guanine nucleotide exchange factor for Arf GTPases, stimulating the nucleotide exchange from the GDP-bound to the GTP-bound form. Involved in vesicular transport (By similarity).


ensembl_gene_id: Q10492
symbol: pnn1
gene_biotype: protein_coding
description:
  Pinin homolog 1; Transcriptional activator that may participate in the regulation of mRNA splicing; Belongs to the pinin family.


ensembl_gene_id: Q10496
symbol: gyp51
gene_biotype: protein_coding
description:
  GTPase activating protein Gyp51; GTPase-activating protein involved in ER to Golgi trafficking and polarized exocytosis; Belongs to the GYP5 family.


ensembl_gene_id: Q10499
symbol: aif1
gene_biotype: protein_coding
description:
  Apoptosis-inducing factor 1; Putative FAD-dependent oxidoreductase involved in the resistance to cercosporin and other singlet oxygen-generating photosensitizers. Translocates from mitochondria to the nucleus under apoptotic conditions, where it degrades DNA and induces apoptosis (By similarity).


ensembl_gene_id: Q10585
symbol: spd1
gene_biotype: protein_coding
description:
  S-phase delaying protein 1; Regulates the ribonucleotide reductase activity through its mediation of the nuclear localization of suc22, the small subunit of the ribonucleotide reductase. Delays the progression of the G1-S phase transition, thereby ensuring the G1 phase is complete. Interacts with both p34 and the p34-p56 complex, although no direct inhibitory effect on the bound proteins has been demonstrated. The action of p14 may happen coincidentally with the cdc10 function or may happen downstream of this.


