# geneInfo

ensembl_gene_id: VF_0002
symbol: trmE
gene_biotype: protein_coding
description:
  tRNA modification GTPase TrmE; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.


ensembl_gene_id: VF_0003
symbol: yidC
gene_biotype: protein_coding
description:
  Cytoplasmic insertase into membrane protein, Sec system; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.


ensembl_gene_id: VF_0004
symbol: rnpA
gene_biotype: protein_coding
description:
  Ribonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.


ensembl_gene_id: VF_0009
symbol: dnaA
gene_biotype: protein_coding
description:
  Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.


ensembl_gene_id: VF_0010
symbol: dnaN
gene_biotype: protein_coding
description:
  DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]


ensembl_gene_id: VF_0011
symbol: recF
gene_biotype: protein_coding
description:
  Gap repair protein; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.


ensembl_gene_id: VF_0012
symbol: gyrB
gene_biotype: protein_coding
description:
  DNA gyrase, subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.


ensembl_gene_id: VF_0019
symbol: tusA
gene_biotype: protein_coding
description:
  Sulfur transfer protein TusA; Sulfur carrier protein which probably makes part of a sulfur- relay system; Belongs to the sulfur carrier protein TusA family.


ensembl_gene_id: VF_0024
symbol: fadA
gene_biotype: protein_coding
description:
  3-ketoacyl-CoA thiolase (thiolase I); Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.


ensembl_gene_id: VF_0025
symbol: fadB
gene_biotype: protein_coding
description:
  Enoyl-CoA hydratase/Delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase/3-hydroxybutyryl-CoA epimerase; Involved in the aerobic and anaerobic degradation of long- chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate. In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.


ensembl_gene_id: VF_0027
symbol: trkH
gene_biotype: protein_coding
description:
  Potassium transporter; Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA; Belongs to the TrkH potassium transport family.


ensembl_gene_id: VF_0032
symbol: thiC
gene_biotype: protein_coding
description:
  Thiamin (pyrimidine moiety) biosynthesis protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.


ensembl_gene_id: VF_0033
symbol: thiE
gene_biotype: protein_coding
description:
  Thiamin phosphate synthase (thiamin phosphate pyrophosphorylase); Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.


ensembl_gene_id: VF_0035
symbol: thiG
gene_biotype: protein_coding
description:
  Thiamin biosynthesis protein ThiG; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.


ensembl_gene_id: VF_0046
symbol: ubiE
gene_biotype: protein_coding
description:
  Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2).


ensembl_gene_id: VF_0048
symbol: ubiB
gene_biotype: protein_coding
description:
  2-octaprenylphenol hydroxylase; Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis.


ensembl_gene_id: VF_0049
symbol: tatA
gene_biotype: protein_coding
description:
  TatABCE protein translocation system subunit; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.


ensembl_gene_id: VF_0050
symbol: tatB
gene_biotype: protein_coding
description:
  TatABCE protein translocation system subunit; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.


ensembl_gene_id: VF_0051
symbol: tatC
gene_biotype: protein_coding
description:
  TatABCE protein translocation system subunit; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.


ensembl_gene_id: VF_0054
symbol: gpp
gene_biotype: protein_coding
description:
  Guanosine pentaphosphatase/exopolyphosphatase; Catalyzes the conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the 'stringent response', an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.


ensembl_gene_id: VF_0056
symbol: rhlB
gene_biotype: protein_coding
description:
  ATP-dependent RNA helicase; DEAD-box RNA helicase involved in RNA degradation. Has RNA- dependent ATPase activity and unwinds double-stranded RNA. Belongs to the DEAD box helicase family. RhlB subfamily.


ensembl_gene_id: VF_0058
symbol: rho
gene_biotype: protein_coding
description:
  Transcription termination factor; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template.


ensembl_gene_id: VF_0060
symbol: ubiD
gene_biotype: protein_coding
description:
  3-octaprenyl-4-hydroxybenzoate decarboxylase; Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol.


ensembl_gene_id: VF_0065
symbol: hemD
gene_biotype: protein_coding
description:
  Uroporphyrinogen III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.


ensembl_gene_id: VF_0066
symbol: hemC
gene_biotype: protein_coding
description:
  Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.


ensembl_gene_id: VF_0073
symbol: yhhQ
gene_biotype: protein_coding
description:
  Conserved inner membrane protein; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.


ensembl_gene_id: VF_0074
symbol: polA
gene_biotype: protein_coding
description:
  Fused DNA polymerase I 5'->3' exonuclease/3'->5' polymerase/3'->5' exonuclease; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.


ensembl_gene_id: VF_0075
symbol: yihA
gene_biotype: protein_coding
description:
  Cell division GTPase YihA; Necessary for normal cell division and for the maintenance of normal septation; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.


ensembl_gene_id: VF_0078
symbol: yihI
gene_biotype: protein_coding
description:
  Conserved protein; A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function. May play a role in ribosome biogenesis. Belongs to the YihI family.


ensembl_gene_id: VF_0080
symbol: hemN
gene_biotype: protein_coding
description:
  Coproporphyrinogen III oxidase, SAM and NAD(P)H dependent, oxygen-independent; Belongs to the anaerobic coproporphyrinogen-III oxidase family.


ensembl_gene_id: VF_0082
symbol: yhiQ
gene_biotype: protein_coding
description:
  SAM-dependent methyltransferase; Specifically methylates the guanosine in position 1516 of 16S rRNA.


ensembl_gene_id: VF_0090
symbol: eda
gene_biotype: protein_coding
description:
  2-dehydro-3-deoxyphosphogluconate aldolase / (4S)-4-hydroxy-2-oxoglutarate aldolase; Multifunctional 2-keto-3-deoxygluconate 6-phosphate aldolase and 2-keto-4-hydroxyglutarate aldolase and oxaloacetate decarboxylase.


ensembl_gene_id: VF_0093
symbol: add
gene_biotype: protein_coding
description:
  Adenosine deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.


ensembl_gene_id: VF_0095
symbol: ntrC
gene_biotype: protein_coding
description:
  DNA-binding transcriptional regulator NtrC; Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes.


ensembl_gene_id: VF_0101
symbol: dtd
gene_biotype: protein_coding
description:
  D-tyr-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family.


ensembl_gene_id: VF_0103
symbol: trmH
gene_biotype: protein_coding
description:
  tRNA (Guanosine-2'-O-)-methyltransferase; Catalyzes the 2'-O methylation of guanosine at position 18 in tRNA; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.


ensembl_gene_id: VF_0104
symbol: spoT
gene_biotype: protein_coding
description:
  Bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.


ensembl_gene_id: VF_0105
symbol: rpoZ
gene_biotype: protein_coding
description:
  RNA polymerase, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.


ensembl_gene_id: VF_0111
symbol: rph
gene_biotype: protein_coding
description:
  Ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.


ensembl_gene_id: VF_0112
symbol: pyrE
gene_biotype: protein_coding
description:
  Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).


ensembl_gene_id: VF_0118
symbol: bioH
gene_biotype: protein_coding
description:
  Carboxylesterase of pimeloyl-CoA synthesis; The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters.


ensembl_gene_id: VF_0121
symbol: greB
gene_biotype: protein_coding
description:
  Transcription elongation factor; Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length.


ensembl_gene_id: VF_0122
symbol: htrB2
gene_biotype: protein_coding
description:
  Lauryl-acyl carrier protein (ACP)-dependent acyltransferase (LpxL); Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(lauroyl)-lipid IV(A).


ensembl_gene_id: VF_0124
symbol: slmA
gene_biotype: protein_coding
description:
  Division inhibitor; Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions.


ensembl_gene_id: VF_0125
symbol: dfp
gene_biotype: protein_coding
description:
  Coenzyme A biosynthesis bifunctional protein CoaBC; Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'- phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'- phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family.


ensembl_gene_id: VF_0126
symbol: yicR
gene_biotype: protein_coding
description:
  Protein associated with replication fork, possible DNA repair protein; Belongs to the UPF0758 family.


ensembl_gene_id: VF_0130
symbol: mutM
gene_biotype: protein_coding
description:
  Formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.


ensembl_gene_id: VF_0132
symbol: coaD
gene_biotype: protein_coding
description:
  Pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family.


ensembl_gene_id: VF_0136
symbol: wavC
gene_biotype: protein_coding
description:
  3-deoxy-D-manno-octulosonic-acid kinase; Catalyzes the ATP-dependent phosphorylation of the 3-deoxy-D- manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position; Belongs to the protein kinase superfamily. KdkA/RfaP family.


ensembl_gene_id: VF_0138
symbol: waaA
gene_biotype: protein_coding
description:
  3-deoxy-D-manno-octulosonic-acid transferase (KDO transferase); Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family.


ensembl_gene_id: VF_0152
symbol: rfaD
gene_biotype: protein_coding
description:
  ADP-L-glycero-D-mannoheptose-6-epimerase, NAD(P)-binding; Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily.


ensembl_gene_id: VF_0164
symbol: etp
gene_biotype: protein_coding
description:
  Phosphotyrosine-protein phosphatase; Belongs to the low molecular weight phosphotyrosine protein phosphatase family.


ensembl_gene_id: VF_0166
symbol: rffG
gene_biotype: protein_coding
description:
  dTDP-glucose 4,6-dehydratase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.


ensembl_gene_id: VF_0167
symbol: rffH
gene_biotype: protein_coding
description:
  Glucose-1-phosphate thymidylyltransferase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family.


ensembl_gene_id: VF_0168
symbol: rfbC
gene_biotype: protein_coding
description:
  dTDP-4-deoxyrhamnose-3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.


ensembl_gene_id: VF_0177
symbol: VF_0177
gene_biotype: protein_coding
description:
  3-deoxy-manno-octulosonate-8-phosphatase; Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8- phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate; Belongs to the KdsC family.


ensembl_gene_id: VF_0178
symbol: kdsB-2
gene_biotype: protein_coding
description:
  3-deoxy-D-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.


ensembl_gene_id: VF_0180
symbol: rfe
gene_biotype: protein_coding
description:
  UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase; Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP-C55). Belongs to the glycosyltransferase 4 family. WecA subfamily.


ensembl_gene_id: VF_0202
symbol: gpmM
gene_biotype: protein_coding
description:
  Phosphoglycero mutase III, cofactor-independent; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate.


ensembl_gene_id: VF_0204
symbol: groS
gene_biotype: protein_coding
description:
  Cpn10 chaperonin GroES, small subunit of GroESL; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.


ensembl_gene_id: VF_0205
symbol: groL
gene_biotype: protein_coding
description:
  Cpn60 chaperonin GroEL, large subunit of GroESL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.


ensembl_gene_id: VF_0206
symbol: tpiA
gene_biotype: protein_coding
description:
  Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family.


ensembl_gene_id: VF_0210
symbol: zapB
gene_biotype: protein_coding
description:
  Transcriptional regulator; Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA.


ensembl_gene_id: VF_0211
symbol: rraA
gene_biotype: protein_coding
description:
  Ribonuclease E (RNase E) inhibitor protein; Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome.


ensembl_gene_id: VF_0212
symbol: menA
gene_biotype: protein_coding
description:
  1,4-dihydroxy-2-naphthoate octaprenyltransferase; Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK); Belongs to the MenA family. Type 1 subfamily.


ensembl_gene_id: VF_0219
symbol: kefG
gene_biotype: protein_coding
description:
  Component of potassium effux complex with KefB; Regulatory subunit of a potassium efflux system that confers protection against electrophiles. Required for full activity of KefB.


ensembl_gene_id: VF_0220
symbol: kefB
gene_biotype: protein_coding
description:
  Potassium:proton antiporter; Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport.


ensembl_gene_id: VF_0228
symbol: tusD
gene_biotype: protein_coding
description:
  Sulfur transfer protein complex, TusD subunit; Could be part of a sulfur-relay system; Belongs to the DsrE/TusD family.


ensembl_gene_id: VF_0229
symbol: tusC
gene_biotype: protein_coding
description:
  Sulfur transfer protein complex, TusC subunit; Could be part of a sulfur-relay system; Belongs to the DsrF/TusC family.


ensembl_gene_id: VF_0230
symbol: rpsL
gene_biotype: protein_coding
description:
  30S ribosomal subunit protein S12; With S4 and S5 plays an important role in translational accuracy.


ensembl_gene_id: VF_0231
symbol: rpsG
gene_biotype: protein_coding
description:
  30S ribosomal subunit protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family.


ensembl_gene_id: VF_0232
symbol: fusA
gene_biotype: protein_coding
description:
  Protein chain elongation factor EF-G, GTP-binding; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase f [...]


ensembl_gene_id: VF_0233
symbol: tufB
gene_biotype: protein_coding
description:
  Protein chain elongation factor EF-Tu (duplicate of tufA); This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis.


ensembl_gene_id: VF_0234
symbol: rpsJ
gene_biotype: protein_coding
description:
  30S ribosomal subunit protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family.


ensembl_gene_id: VF_0237
symbol: rplD
gene_biotype: protein_coding
description:
  50S ribosomal subunit protein L4; One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.


ensembl_gene_id: VF_0238
symbol: rplW
gene_biotype: protein_coding
description:
  50S ribosomal subunit protein L23; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family.


ensembl_gene_id: VF_0239
symbol: rplB
gene_biotype: protein_coding
description:
  50S ribosomal subunit protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family.


ensembl_gene_id: VF_0240
symbol: rpsS
gene_biotype: protein_coding
description:
  30S ribosomal subunit protein S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.


ensembl_gene_id: VF_0241
symbol: rplV
gene_biotype: protein_coding
description:
  50S ribosomal subunit protein L22; This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity).


ensembl_gene_id: VF_0242
symbol: rpsC
gene_biotype: protein_coding
description:
  30S ribosomal subunit protein S3; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family.


ensembl_gene_id: VF_0243
symbol: rplP
gene_biotype: protein_coding
description:
  50S ribosomal subunit protein L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family.


ensembl_gene_id: VF_0245
symbol: rpsQ
gene_biotype: protein_coding
description:
  30S ribosomal subunit protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.


ensembl_gene_id: VF_0246
symbol: rplN
gene_biotype: protein_coding
description:
  50S ribosomal subunit protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family.


ensembl_gene_id: VF_0248
symbol: rplX
gene_biotype: protein_coding
description:
  50S ribosomal subunit protein L24; One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.


ensembl_gene_id: VF_0249
symbol: rplE
gene_biotype: protein_coding
description:
  50S ribosomal subunit protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.


ensembl_gene_id: VF_0250
symbol: rpsN
gene_biotype: protein_coding
description:
  30S ribosomal subunit protein S14; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site; Belongs to the universal ribosomal protein uS14 family.


ensembl_gene_id: VF_0251
symbol: rpsH
gene_biotype: protein_coding
description:
  30S ribosomal subunit protein S8; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family.


ensembl_gene_id: VF_0252
symbol: rplF
gene_biotype: protein_coding
description:
  50S ribosomal subunit protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family.


ensembl_gene_id: VF_0253
symbol: rplR
gene_biotype: protein_coding
description:
  50S ribosomal subunit protein L18; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.


ensembl_gene_id: VF_0254
symbol: rpsE
gene_biotype: protein_coding
description:
  30S ribosomal subunit protein S5; With S4 and S12 plays an important role in translational accuracy; Belongs to the universal ribosomal protein uS5 family.


ensembl_gene_id: VF_0256
symbol: rplO
gene_biotype: protein_coding
description:
  50S ribosomal subunit protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family.


ensembl_gene_id: VF_0257
symbol: secY
gene_biotype: protein_coding
description:
  Preprotein translocase membrane subunit; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.


ensembl_gene_id: VF_0259
symbol: rpsM
gene_biotype: protein_coding
description:
  30S ribosomal subunit protein S13; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Belongs to the universal ribosomal protein uS13 family.


ensembl_gene_id: VF_0260
symbol: rpsK
gene_biotype: protein_coding
description:
  30S ribosomal subunit protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family.


ensembl_gene_id: VF_0261
symbol: rpsD
gene_biotype: protein_coding
description:
  30S ribosomal subunit protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.


ensembl_gene_id: VF_0262
symbol: rpoA
gene_biotype: protein_coding
description:
  RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.


ensembl_gene_id: VF_0265
symbol: mpl
gene_biotype: protein_coding
description:
  UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl- meso-diaminopimelate by linking it to UDP-N-acetylmuramate. Belongs to the MurCDEF family. Mpl subfamily.


ensembl_gene_id: VF_0266
symbol: ubiX
gene_biotype: protein_coding
description:
  3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family.


ensembl_gene_id: VF_0267
symbol: thiB
gene_biotype: protein_coding
description:
  Thiamine/thiamine pyrophosphate ABC transporter, thiamine/thiamine pyrophospate-binding protein ThiB/TbpA/SfuA.


ensembl_gene_id: VF_0269
symbol: thiQ
gene_biotype: protein_coding
description:
  Thiamine ABC transporter, ATP-binding protein ThiQ/SfuC; Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Thiamine importer (TC 3.A.1.19.1) family.


ensembl_gene_id: VF_0270
symbol: hepA
gene_biotype: protein_coding
description:
  RNA polymerase-associated helicase protein (ATPase and RNA polymerase recycling factor); Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair; Belongs to the SNF2/RAD54 helicase family. RapA subfamily.


ensembl_gene_id: VF_0271
symbol: rluA
gene_biotype: protein_coding
description:
  Pseudouridine synthase for 23S rRNA and tRNAphe; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family.


ensembl_gene_id: VF_0278
symbol: rplU
gene_biotype: protein_coding
description:
  50S ribosomal subunit protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family.


ensembl_gene_id: VF_0280
symbol: obgE
gene_biotype: protein_coding
description:
  GTPase involved in cell partioning and DNA repair; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.


ensembl_gene_id: VF_0284
symbol: folA
gene_biotype: protein_coding
description:
  Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.


ensembl_gene_id: VF_0285
symbol: apaH
gene_biotype: protein_coding
description:
  Diadenosine tetraphosphatase; Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP; Belongs to the Ap4A hydrolase family.


ensembl_gene_id: VF_0286
symbol: ksgA
gene_biotype: protein_coding
description:
  S-adenosylmethionine-6-N',N'-adenosyl (rRNA) dimethyltransferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.


ensembl_gene_id: VF_0287
symbol: pdxA
gene_biotype: protein_coding
description:
  4-hydroxy-L-threonine phosphate dehydrogenase, NAD-dependent; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).


ensembl_gene_id: VF_0288
symbol: surA
gene_biotype: protein_coding
description:
  Peptidyl-prolyl cis-trans isomerase (PPIase); Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation.


ensembl_gene_id: VF_0289
symbol: imp
gene_biotype: protein_coding
description:
  Exported protein required for envelope (LPS) biosynthesis and integrity; Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.


ensembl_gene_id: VF_0290
symbol: djlA
gene_biotype: protein_coding
description:
  DnaJ-like protein, membrane anchored; Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB/RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host.


ensembl_gene_id: VF_0292
symbol: leuD
gene_biotype: protein_coding
description:
  3-isopropylmalate isomerase subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.


ensembl_gene_id: VF_0293
symbol: leuC
gene_biotype: protein_coding
description:
  3-isopropylmalate isomerase subunit, dehydratase component; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.


ensembl_gene_id: VF_0294
symbol: leuB
gene_biotype: protein_coding
description:
  3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.


ensembl_gene_id: VF_0295
symbol: leuA
gene_biotype: protein_coding
description:
  2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.


ensembl_gene_id: VF_0298
symbol: VF_0298
gene_biotype: protein_coding
description:
  Acriflavin resistance plasma membrane protein; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.


ensembl_gene_id: VF_0301
symbol: dnaB
gene_biotype: protein_coding
description:
  Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily.


ensembl_gene_id: VF_0302
symbol: alr
gene_biotype: protein_coding
description:
  Alanine racemase 1, PLP-binding, biosynthetic; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family.


ensembl_gene_id: VF_0307
symbol: dusA
gene_biotype: protein_coding
description:
  NifR3/Smm1 family protein; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs; Belongs to the Dus family. DusA subfamily.


ensembl_gene_id: VF_0310
symbol: cysJ
gene_biotype: protein_coding
description:
  Sulfite reductase, alpha subunit, flavoprotein; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component; Belongs to the NADPH-dependent sulphite reductase flavoprotein subunit CysJ family. In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.


ensembl_gene_id: VF_0311
symbol: cysI
gene_biotype: protein_coding
description:
  Sulfite reductase, beta subunit, NAD(P)-binding, heme-binding; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.


ensembl_gene_id: VF_0312
symbol: cysH
gene_biotype: protein_coding
description:
  3'-phosphoadenosine 5'-phosphosulfate reductase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily.


ensembl_gene_id: VF_0321
symbol: cysN
gene_biotype: protein_coding
description:
  Sulfate adenylyltransferase, subunit 1; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily.


ensembl_gene_id: VF_0331
symbol: msrA
gene_biotype: protein_coding
description:
  Peptide-methionine (S)-S-oxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.


ensembl_gene_id: VF_0337
symbol: metH
gene_biotype: protein_coding
description:
  homocysteine-N5-methyltetrahydrofolate transmethylase, B12-dependent; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity).


ensembl_gene_id: VF_0341
symbol: uvrA
gene_biotype: protein_coding
description:
  ATPase and DNA damage recognition protein of nucleotide excision repair excinuclease UvrABC; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.


ensembl_gene_id: VF_0353
symbol: ssb
gene_biotype: protein_coding
description:
  Single-stranded DNA-binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.


ensembl_gene_id: VF_0373
symbol: mreC
gene_biotype: protein_coding
description:
  Cell wall structural complex MreBCD transmembrane component MreC; Involved in formation and maintenance of cell shape.


ensembl_gene_id: VF_0374
symbol: mreD
gene_biotype: protein_coding
description:
  Cell wall structural complex MreBCD transmembrane component MreD; Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins. Belongs to the MreD family.


ensembl_gene_id: VF_0375
symbol: yhdE
gene_biotype: protein_coding
description:
  Conserved protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.


ensembl_gene_id: VF_0384
symbol: yhbJ
gene_biotype: protein_coding
description:
  Predicted protein with nucleoside triphosphate hydrolase domain; Displays ATPase and GTPase activities.


ensembl_gene_id: VF_0387
symbol: rpoN
gene_biotype: protein_coding
description:
  RNA polymerase, sigma 54 (sigma N) factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.


ensembl_gene_id: VF_0389
symbol: lptA
gene_biotype: protein_coding
description:
  Predicted transporter subunit: periplasmic-binding component of ABC superfamily; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm.


ensembl_gene_id: VF_0390
symbol: lptC
gene_biotype: protein_coding
description:
  Probable exported protein; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA. Belongs to the LptC family.


ensembl_gene_id: VF_0391
symbol: kdsC
gene_biotype: protein_coding
description:
  3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8- phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate; Belongs to the KdsC family.


ensembl_gene_id: VF_0401
symbol: murA
gene_biotype: protein_coding
description:
  UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily.


ensembl_gene_id: VF_0402
symbol: plsC
gene_biotype: protein_coding
description:
  1-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.


ensembl_gene_id: VF_0403
symbol: idi
gene_biotype: protein_coding
description:
  Isopentenyl-diphosphate delta-isomerase; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).


ensembl_gene_id: VF_0405
symbol: pyrI
gene_biotype: protein_coding
description:
  Aspartate carbamoyltransferase, regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase.


ensembl_gene_id: VF_0406
symbol: pyrB
gene_biotype: protein_coding
description:
  Aspartate carbamoyltransferase, catalytic subunit; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.


ensembl_gene_id: VF_0407
symbol: argI
gene_biotype: protein_coding
description:
  Ornithine carbamoyltransferase 1; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.


ensembl_gene_id: VF_0409
symbol: rraB
gene_biotype: protein_coding
description:
  Conserved protein; Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome.


ensembl_gene_id: VF_0411
symbol: valS
gene_biotype: protein_coding
description:
  valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.


ensembl_gene_id: VF_0413
symbol: pepA
gene_biotype: protein_coding
description:
  Aminopeptidase A, a cyteinylglycinase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides.


ensembl_gene_id: VF_0418
symbol: dgkA
gene_biotype: protein_coding
description:
  Diacylglycerol kinase; Recycling of diacylglycerol produced during the turnover of membrane phospholipid.


ensembl_gene_id: VF_0420
symbol: mltC
gene_biotype: protein_coding
description:
  Membrane-bound lytic murein transglycosylase C; Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division.


ensembl_gene_id: VF_0421
symbol: yggX
gene_biotype: protein_coding
description:
  Protein that protects iron-sulfur proteins against oxidative damage; Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes.


ensembl_gene_id: VF_0424
symbol: yggW
gene_biotype: protein_coding
description:
  Predicted oxidoreductase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family.


ensembl_gene_id: VF_0425
symbol: rdgB
gene_biotype: protein_coding
description:
  dITP/XTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.


ensembl_gene_id: VF_0429
symbol: proC
gene_biotype: protein_coding
description:
  Pyrroline-5-carboxylate reductase, NAD(P)-binding; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.


ensembl_gene_id: VF_0430
symbol: yggS
gene_biotype: protein_coding
description:
  Predicted enzyme; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.


ensembl_gene_id: VF_0433
symbol: yqgF
gene_biotype: protein_coding
description:
  Predicted Holliday junction resolvase; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF nuclease family.


ensembl_gene_id: VF_0436
symbol: rsmE
gene_biotype: protein_coding
description:
  Predicted protein; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.


ensembl_gene_id: VF_0439
symbol: metK
gene_biotype: protein_coding
description:
  Methionine adenosyltransferase 1; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.


ensembl_gene_id: VF_0440
symbol: tktA
gene_biotype: protein_coding
description:
  Transketolase 1, thiamin-binding; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.


ensembl_gene_id: VF_0441
symbol: epd
gene_biotype: protein_coding
description:
  D-erythrose 4-phosphate dehydrogenase; Catalyzes the NAD-dependent conversion of D-erythrose 4- phosphate to 4-phosphoerythronate.


ensembl_gene_id: VF_0443
symbol: fbaA
gene_biotype: protein_coding
description:
  Fructose-bisphosphate aldolase, class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family.


ensembl_gene_id: VF_0444
symbol: srmB
gene_biotype: protein_coding
description:
  ATP-dependent RNA helicase; DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit at low temperature. Exhibits RNA-stimulated ATP hydrolysis and RNA unwinding activity; Belongs to the DEAD box helicase family. SrmB subfamily.


ensembl_gene_id: VF_0445
symbol: yfiC
gene_biotype: protein_coding
description:
  Predicted S-adenosyl-L-methionine-dependent methyltransferase; Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC).


ensembl_gene_id: VF_0446
symbol: brnQ
gene_biotype: protein_coding
description:
  Predicted branched chain amino acid transporter (LIV-II); Component of the transport system for branched-chain amino acids.


ensembl_gene_id: VF_0447
symbol: fldB
gene_biotype: protein_coding
description:
  Flavodoxin 2; Low-potential electron donor to a number of redox enzymes. Belongs to the flavodoxin family.


ensembl_gene_id: VF_0448
symbol: xerD
gene_biotype: protein_coding
description:
  Site-specific tyrosine recombinase; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.


ensembl_gene_id: VF_0449
symbol: dsbC
gene_biotype: protein_coding
description:
  Protein disulfide isomerase II; Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process; Belongs to the thioredoxin family. DsbC subfamily.


ensembl_gene_id: VF_0452
symbol: prfB
gene_biotype: protein_coding
description:
  Peptide chain release factor RF-2; Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.


ensembl_gene_id: VF_0455
symbol: mutH
gene_biotype: protein_coding
description:
  Methyl-directed mismatch repair protein; Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair. Belongs to the MutH family.


ensembl_gene_id: VF_0456
symbol: nudH
gene_biotype: protein_coding
description:
  Nucleotide hydrolase; Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily.


ensembl_gene_id: VF_0457
symbol: ptsP
gene_biotype: protein_coding
description:
  Fused PTS enzyme: PEP-protein phosphotransferase (enzyme I)/GAF domain containing protein; Belongs to the PEP-utilizing enzyme family.


ensembl_gene_id: VF_0459
symbol: lgt
gene_biotype: protein_coding
description:
  Phosphatidylglycerol-prolipoprotein diacylglyceryl transferase; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family.


ensembl_gene_id: VF_0460
symbol: thyA
gene_biotype: protein_coding
description:
  Thymidylate synthetase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.


ensembl_gene_id: VF_0465
symbol: yceN
gene_biotype: protein_coding
description:
  Predicted inner membrane protein; Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.


ensembl_gene_id: VF_0467
symbol: ileS
gene_biotype: protein_coding
description:
  isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.


ensembl_gene_id: VF_0468
symbol: lspA
gene_biotype: protein_coding
description:
  Prolipoprotein signal peptidase (signal peptidase II); This protein specifically catalyzes the removal of signal peptides from prolipoproteins; Belongs to the peptidase A8 family.


ensembl_gene_id: VF_0470
symbol: ispH
gene_biotype: protein_coding
description:
  1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase, 4Fe-4S protein; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family.


ensembl_gene_id: VF_0471
symbol: dapB
gene_biotype: protein_coding
description:
  Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.


ensembl_gene_id: VF_0472
symbol: carA
gene_biotype: protein_coding
description:
  Carbamoyl phosphate synthetase small subunit, glutamine amidotransferase; Belongs to the CarA family.


ensembl_gene_id: VF_0476
symbol: greA
gene_biotype: protein_coding
description:
  Transcription elongation factor; Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.


ensembl_gene_id: VF_0478
symbol: rrmJ
gene_biotype: protein_coding
description:
  23S rRNA methyltransferase; Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.


ensembl_gene_id: VF_0479
symbol: hflB
gene_biotype: protein_coding
description:
  ATP-dependent zinc-metalloprotease; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family.  In the central section; belongs to the AAA ATPase family.


ensembl_gene_id: VF_0480
symbol: folP
gene_biotype: protein_coding
description:
  7,8-dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives.


ensembl_gene_id: VF_0481
symbol: glmM
gene_biotype: protein_coding
description:
  Phosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family.


ensembl_gene_id: VF_0483
symbol: secG
gene_biotype: protein_coding
description:
  Preprotein translocase membrane subunit; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family.


ensembl_gene_id: VF_0485
symbol: nusA
gene_biotype: protein_coding
description:
  Transcription termination/antitermination L factor NusA; Participates in both transcription termination and antitermination.


ensembl_gene_id: VF_0486
symbol: infB
gene_biotype: protein_coding
description:
  Fused protein chain initiation factor 2, IF2: membrane protein/conserved protein; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.


ensembl_gene_id: VF_0487
symbol: rbfA
gene_biotype: protein_coding
description:
  30s ribosome binding factor; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.


ensembl_gene_id: VF_0488
symbol: truB
gene_biotype: protein_coding
description:
  tRNA pseudouridine synthase; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.


ensembl_gene_id: VF_0489
symbol: rpsO
gene_biotype: protein_coding
description:
  30S ribosomal subunit protein S15; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.


ensembl_gene_id: VF_0490
symbol: pnp
gene_biotype: protein_coding
description:
  Polynucleotide phosphorylase (PNPase); Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction.


ensembl_gene_id: VF_0498
symbol: holD
gene_biotype: protein_coding
description:
  DNA polymerase III, psi subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is unknown.


ensembl_gene_id: VF_0499
symbol: rimI
gene_biotype: protein_coding
description:
  Acetylase for 30S ribosomal subunit protein S18; Acetylates the N-terminal alanine of ribosomal protein S18.


ensembl_gene_id: VF_0500
symbol: prfC
gene_biotype: protein_coding
description:
  Peptide chain release factor RF-3; Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.


ensembl_gene_id: VF_0502
symbol: yeiM
gene_biotype: protein_coding
description:
  Predicted nucleoside transporter; Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.


ensembl_gene_id: VF_0504
symbol: deoC
gene_biotype: protein_coding
description:
  2-deoxyribose-5-phosphate aldolase, NAD(P)-linked; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily.


ensembl_gene_id: VF_0505
symbol: deoA
gene_biotype: protein_coding
description:
  Thymidine phosphorylase; The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.


ensembl_gene_id: VF_0506
symbol: deoB
gene_biotype: protein_coding
description:
  Phosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family.


ensembl_gene_id: VF_0521
symbol: tadF1
gene_biotype: protein_coding
description:
  ATP/GTP-binding site motif A (P-loop) surface protein involved in fimbraea and/or secretion, TadF-like protein.


ensembl_gene_id: VF_0528
symbol: radA
gene_biotype: protein_coding
description:
  Predicted repair protein; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.


ensembl_gene_id: VF_0534
symbol: mutS
gene_biotype: protein_coding
description:
  Methyl-directed mismatch repair protein; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.


ensembl_gene_id: VF_0535
symbol: recA
gene_biotype: protein_coding
description:
  DNA strand exchange and recombination protein with protease and nuclease activity; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.


ensembl_gene_id: VF_0536
symbol: alaS
gene_biotype: protein_coding
description:
  alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.


ensembl_gene_id: VF_0538
symbol: csrA
gene_biotype: protein_coding
description:
  Pleiotropic regulatory protein for carbon source metabolism; A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small [...]


ensembl_gene_id: VF_0540
symbol: oadB
gene_biotype: protein_coding
description:
  Oxaloacetate decarboxylase beta subunit; Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation; Belongs to the GcdB/MmdB/OadB family.


ensembl_gene_id: VF_0543
symbol: gshA
gene_biotype: protein_coding
description:
  Gamma-glutamate-cysteine ligase; Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily.


ensembl_gene_id: VF_0545
symbol: luxS
gene_biotype: protein_coding
description:
  S-ribosylhomocysteinase, autoinducer-2 synthase protein LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family.


ensembl_gene_id: VF_0548
symbol: ffh
gene_biotype: protein_coding
description:
  Signal Recognition Particle (SRP) component with 4.5S RNA (ffs); Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex  [...]


ensembl_gene_id: VF_0550
symbol: rimM
gene_biotype: protein_coding
description:
  16S rRNA processing protein; An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes; Belongs to the RimM family.


ensembl_gene_id: VF_0551
symbol: trmD
gene_biotype: protein_coding
description:
  tRNA (guanine-1-)-methyltransferase; Specifically methylates guanosine-37 in various tRNAs. Belongs to the RNA methyltransferase TrmD family.


ensembl_gene_id: VF_0552
symbol: rplS
gene_biotype: protein_coding
description:
  50S ribosomal subunit protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.


ensembl_gene_id: VF_0553
symbol: aroF
gene_biotype: protein_coding
description:
  3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, tyrosine-repressible; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP).


ensembl_gene_id: VF_0556
symbol: VF_0556
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Binds the second messenger bis-(3'-5') cyclic dimeric guanosine monophosphate (c-di-GMP). Can bind two c-di-GMP molecules per monomer. May play a role in bacterial second-messenger regulated processes. Binding to c-di-GMP induces a conformational change of the C- and N-termini resulting in the exposure of a highly negative surface on one side of the protein to a possible effector protein.


ensembl_gene_id: VF_0559
symbol: trpR
gene_biotype: protein_coding
description:
  DNA-binding transcriptional repressor, tryptophan-binding; This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon and prevents the initiation of transcription.


ensembl_gene_id: VF_0560
symbol: yjjX
gene_biotype: protein_coding
description:
  Thiamin metabolism associated protein; Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.


ensembl_gene_id: VF_0563
symbol: yfiO
gene_biotype: protein_coding
description:
  Lipoprotein component of outer membrane protein assembly complex; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.


ensembl_gene_id: VF_0564
symbol: rluD
gene_biotype: protein_coding
description:
  23S rRNA pseudouridine synthase; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family.


ensembl_gene_id: VF_0566
symbol: clpB
gene_biotype: protein_coding
description:
  Protein disaggregation chaperone; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family.


ensembl_gene_id: VF_0576
symbol: dapD
gene_biotype: protein_coding
description:
  2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA.


ensembl_gene_id: VF_0579
symbol: yeiE
gene_biotype: protein_coding
description:
  Predicted DNA-binding transcriptional regulator; Belongs to the LysR transcriptional regulatory family.


ensembl_gene_id: VF_0581
symbol: recC
gene_biotype: protein_coding
description:
  Exonuclease V (RecBCD complex), gamma subunit; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombinati [...]


ensembl_gene_id: VF_0582
symbol: recB
gene_biotype: protein_coding
description:
  Exonuclease V (RecBCD complex), beta subunit; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombinatio [...]


ensembl_gene_id: VF_0583
symbol: recD
gene_biotype: protein_coding
description:
  Exonuclease V (RecBCD complex), alpha subunit; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombinati [...]


ensembl_gene_id: VF_0587
symbol: mltA
gene_biotype: protein_coding
description:
  Membrane-bound lytic murein transglycosylase A; Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division.


ensembl_gene_id: VF_0590
symbol: csdA
gene_biotype: protein_coding
description:
  Cysteine sulfinate desulfinase; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.


ensembl_gene_id: VF_0591
symbol: gcvA
gene_biotype: protein_coding
description:
  DNA-binding transcriptional dual regulator, glycine cleavage system transcriptional activator; Belongs to the LysR transcriptional regulatory family.


ensembl_gene_id: VF_0593
symbol: ygdE
gene_biotype: protein_coding
description:
  Predicted methyltransferase; Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily.


ensembl_gene_id: VF_0594
symbol: xni
gene_biotype: protein_coding
description:
  Exonuclease IX (5'-3' exonuclease); Has flap endonuclease activity. During DNA replication, flap endonucleases cleave the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.


ensembl_gene_id: VF_0598
symbol: queF
gene_biotype: protein_coding
description:
  Hypothetical protein; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).


ensembl_gene_id: VF_0599
symbol: syd
gene_biotype: protein_coding
description:
  Predicted protein; Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function. Belongs to the Syd family.


ensembl_gene_id: VF_0603
symbol: VF_0603
gene_biotype: protein_coding
description:
  PTS system, cellobiose-utilization IIC component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.


ensembl_gene_id: VF_0615
symbol: trmJ
gene_biotype: protein_coding
description:
  Predicted methyltransferase; Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA.


ensembl_gene_id: VF_0616
symbol: iscR
gene_biotype: protein_coding
description:
  Fe-S cluster synthesis regulatory protein IscR, DNA-binding transcriptional repressor; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins.


ensembl_gene_id: VF_0617
symbol: iscS
gene_biotype: protein_coding
description:
  Cysteine desulfurase IscS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.


ensembl_gene_id: VF_0618
symbol: iscU
gene_biotype: protein_coding
description:
  Fe-S cluster assembly scaffold protein IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.


ensembl_gene_id: VF_0619
symbol: iscA
gene_biotype: protein_coding
description:
  Fe-S cluster assembly protein IscA; Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system; Belongs to the HesB/IscA family.


ensembl_gene_id: VF_0620
symbol: hscB
gene_biotype: protein_coding
description:
  DnaJ-like molecular chaperone specific for Fe-S scaffold IscU; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family.


ensembl_gene_id: VF_0621
symbol: hscA
gene_biotype: protein_coding
description:
  DnaK-like molecular chaperone specific for Fe-S scaffold IscU; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB.


ensembl_gene_id: VF_0625
symbol: ndk
gene_biotype: protein_coding
description:
  Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.


ensembl_gene_id: VF_0626
symbol: yfgB
gene_biotype: protein_coding
description:
  Predicted enzyme; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity; Belongs to the radical SAM superfamily. RlmN family.


ensembl_gene_id: VF_0629
symbol: ispG
gene_biotype: protein_coding
description:
  1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family.


ensembl_gene_id: VF_0633
symbol: der
gene_biotype: protein_coding
description:
  Predicted GTP-binding protein; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.


ensembl_gene_id: VF_0636
symbol: xseA
gene_biotype: protein_coding
description:
  Exonuclease VII, large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family.


ensembl_gene_id: VF_0637
symbol: guaB
gene_biotype: protein_coding
description:
  IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.


ensembl_gene_id: VF_0645
symbol: frmA
gene_biotype: protein_coding
description:
  Alcohol dehydrogenase class III/glutathione-dependent formaldehyde dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.


ensembl_gene_id: VF_0647
symbol: VF_0647
gene_biotype: protein_coding
description:
  Proton/sodium-glutamate symport protein; Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.


ensembl_gene_id: VF_0649
symbol: yafC
gene_biotype: protein_coding
description:
  Predicted DNA-binding transcriptional regulator, LysR family; Belongs to the LysR transcriptional regulatory family.


ensembl_gene_id: VF_0650
symbol: tadA
gene_biotype: protein_coding
description:
  tRNA-specific adenosine deaminase; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family.


ensembl_gene_id: VF_0651
symbol: mltF
gene_biotype: protein_coding
description:
  Amino-acid abc transporter binding protein; Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella. In the N-terminal section; belongs to the bacterial solute- binding protein 3 family.


ensembl_gene_id: VF_0652
symbol: purL
gene_biotype: protein_coding
description:
  Phosphoribosylformyl-glycineamide synthetase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.


ensembl_gene_id: VF_0666
symbol: nanE
gene_biotype: protein_coding
description:
  N-acetylmannosamine-6-P epimerase; Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N- acetylglucosamine-6-phosphate (GlcNAc-6-P).


ensembl_gene_id: VF_0668
symbol: nanT
gene_biotype: protein_coding
description:
  N-acetylneuraminate transporter, sodium-glucose/galactose cotransporter; Seems to be involved in N-acetylneuraminate transport. Complements an E. coli nanT deletion mutant.


ensembl_gene_id: VF_0670
symbol: ureG
gene_biotype: protein_coding
description:
  Urease accessory protein UreG; Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.


ensembl_gene_id: VF_0671
symbol: ureF
gene_biotype: protein_coding
description:
  Urease accessory protein UreF; Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.


ensembl_gene_id: VF_0672
symbol: ureE
gene_biotype: protein_coding
description:
  Urease accessory protein UreE; Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly. Belongs to the UreE family.


ensembl_gene_id: VF_0673
symbol: ureC
gene_biotype: protein_coding
description:
  Urea amidohydrolase, alpha subunit; Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.


ensembl_gene_id: VF_0676
symbol: ureD
gene_biotype: protein_coding
description:
  Urease accessory protein UreD; Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.


ensembl_gene_id: VF_0682
symbol: proS
gene_biotype: protein_coding
description:
  prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves dea [...]


ensembl_gene_id: VF_0686
symbol: metN
gene_biotype: protein_coding
description:
  DL-methionine transporter subunit; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system.


ensembl_gene_id: VF_0695
symbol: glyA
gene_biotype: protein_coding
description:
  Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.


ensembl_gene_id: VF_0699
symbol: nrdR
gene_biotype: protein_coding
description:
  Transcriptional repressor NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family.


ensembl_gene_id: VF_0700
symbol: ribD
gene_biotype: protein_coding
description:
  Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.


ensembl_gene_id: VF_0702
symbol: ribB
gene_biotype: protein_coding
description:
  3,4-dihydroxy-2-butanone-4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family.


ensembl_gene_id: VF_0703
symbol: ribH
gene_biotype: protein_coding
description:
  Riboflavin synthase, beta subunit; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family.


ensembl_gene_id: VF_0704
symbol: nusB
gene_biotype: protein_coding
description:
  Transcription antitermination factor NusB; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.


ensembl_gene_id: VF_0705
symbol: thiL
gene_biotype: protein_coding
description:
  Thiamin-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family.


ensembl_gene_id: VF_0706
symbol: pgpA
gene_biotype: protein_coding
description:
  Phosphatidylglycerophosphatase A; Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG).


ensembl_gene_id: VF_0711
symbol: dxs
gene_biotype: protein_coding
description:
  1-deoxyxylulose-5-phosphate synthase, thiamine-requiring, FAD-requiring; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily.


ensembl_gene_id: VF_0713
symbol: xseB
gene_biotype: protein_coding
description:
  Exodeoxyribonuclease VII, small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family.


ensembl_gene_id: VF_0716
symbol: thiI
gene_biotype: protein_coding
description:
  Sulfurtransferase required for thiamine and 4-thiouridine biosynthesis; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.


ensembl_gene_id: VF_0718
symbol: panE
gene_biotype: protein_coding
description:
  2-dehydropantoate reductase, NADPH-specific; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.


ensembl_gene_id: VF_0721
symbol: VF_0721
gene_biotype: protein_coding
description:
  Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.


ensembl_gene_id: VF_0723
symbol: rlmG
gene_biotype: protein_coding
description:
  Predicted methyltransferase small domain; Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA.


ensembl_gene_id: VF_0724
symbol: bolA
gene_biotype: protein_coding
description:
  Regulator of penicillin binding proteins and beta lactamase transcription (morphogene); Belongs to the BolA/IbaG family.


ensembl_gene_id: VF_0725
symbol: nqrA
gene_biotype: protein_coding
description:
  Sodium-translocating NADH:quinone oxidoreductase, subunit A; NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.


ensembl_gene_id: VF_0726
symbol: nqrB
gene_biotype: protein_coding
description:
  Sodium-translocating NADH:quinone oxidoreductase, subunit B; NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.


ensembl_gene_id: VF_0727
symbol: nqrC
gene_biotype: protein_coding
description:
  Sodium-translocating NADH:quinone oxidoreductase, subunit C; NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.


ensembl_gene_id: VF_0728
symbol: nqrD
gene_biotype: protein_coding
description:
  Sodium-translocating NADH:quinone oxidoreductase, subunit D; NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol; Belongs to the NqrDE/RnfAE family.


ensembl_gene_id: VF_0729
symbol: nqrE
gene_biotype: protein_coding
description:
  Sodium-translocating NADH:quinone oxidoreductase, subunit E; NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol; Belongs to the NqrDE/RnfAE family.


ensembl_gene_id: VF_0731
symbol: nqrF
gene_biotype: protein_coding
description:
  Sodium-translocating NADH:quinone oxidoreductase, subunit F; NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway.


ensembl_gene_id: VF_0732
symbol: apbE
gene_biotype: protein_coding
description:
  Predicted thiamine biosynthesis lipoprotein; Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein. Belongs to the ApbE family.


ensembl_gene_id: VF_0734
symbol: dinB
gene_biotype: protein_coding
description:
  DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.


ensembl_gene_id: VF_0735
symbol: VF_0735
gene_biotype: protein_coding
description:
  Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family.


ensembl_gene_id: VF_0738
symbol: gpt
gene_biotype: protein_coding
description:
  Guanine-hypoxanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily.


ensembl_gene_id: VF_0740
symbol: proB
gene_biotype: protein_coding
description:
  Gamma-glutamate kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.


ensembl_gene_id: VF_0741
symbol: proA
gene_biotype: protein_coding
description:
  Gamma-glutamylphosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family.


ensembl_gene_id: VF_0742
symbol: lipA
gene_biotype: protein_coding
description:
  Lipoate synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.


ensembl_gene_id: VF_0743
symbol: lipB
gene_biotype: protein_coding
description:
  Lipoyl-protein ligase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.


ensembl_gene_id: VF_0745
symbol: dacA
gene_biotype: protein_coding
description:
  D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5); Belongs to the peptidase S11 family.


ensembl_gene_id: VF_0746
symbol: rlpA
gene_biotype: protein_coding
description:
  Minor lipoprotein; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.


ensembl_gene_id: VF_0747
symbol: mrdB
gene_biotype: protein_coding
description:
  Cell wall shape-determining protein; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily.


ensembl_gene_id: VF_0748
symbol: mrdA
gene_biotype: protein_coding
description:
  Transpeptidase (penicillin-binding protein 2); Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily.


ensembl_gene_id: VF_0749
symbol: ybeA
gene_biotype: protein_coding
description:
  Conserved protein; Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA; Belongs to the RNA methyltransferase RlmH family.


ensembl_gene_id: VF_0750
symbol: ybeB
gene_biotype: protein_coding
description:
  Predicted protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.


ensembl_gene_id: VF_0752
symbol: rlpB
gene_biotype: protein_coding
description:
  Lipoprotein component of outer membrane LPS assembly complex; Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane.


ensembl_gene_id: VF_0755
symbol: lnt
gene_biotype: protein_coding
description:
  Apolipoprotein N-acyltransferase; Catalyzes the phospholipid dependent N-acylation of the N- terminal cysteine of apolipoprotein, the last step in lipoprotein maturation; Belongs to the CN hydrolase family. Apolipoprotein N- acyltransferase subfamily.


ensembl_gene_id: VF_0757
symbol: ybeY
gene_biotype: protein_coding
description:
  Conserved protein; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.


ensembl_gene_id: VF_0759
symbol: miaB
gene_biotype: protein_coding
description:
  Isopentenyl-adenosine A37 tRNA methylthiolase; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.


ensembl_gene_id: VF_0762
symbol: ychF
gene_biotype: protein_coding
description:
  Predicted GTP-binding protein; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.


ensembl_gene_id: VF_0764
symbol: prs
gene_biotype: protein_coding
description:
  Phosphoribosylpyrophosphate synthase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.


ensembl_gene_id: VF_0765
symbol: ispE
gene_biotype: protein_coding
description:
  4-diphosphocytidyl-2-C-methylerythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.


ensembl_gene_id: VF_0766
symbol: lolB
gene_biotype: protein_coding
description:
  Lipoprotein chaperone; Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein.


ensembl_gene_id: VF_0767
symbol: hemA
gene_biotype: protein_coding
description:
  Glutamyl tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).


ensembl_gene_id: VF_0768
symbol: prfA
gene_biotype: protein_coding
description:
  Peptide chain release factor RF-1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.


ensembl_gene_id: VF_0769
symbol: prmC
gene_biotype: protein_coding
description:
  N5-glutamine methyltransferase, modifies release factors RF-1 and RF-2; Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif; Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.


ensembl_gene_id: VF_0776
symbol: nirB
gene_biotype: protein_coding
description:
  Nitrite reductase, large subunit, NAD(P)H-binding; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.


ensembl_gene_id: VF_0793
symbol: adk
gene_biotype: protein_coding
description:
  Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.


ensembl_gene_id: VF_0794
symbol: hemH
gene_biotype: protein_coding
description:
  Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.


ensembl_gene_id: VF_0795
symbol: tig
gene_biotype: protein_coding
description:
  Peptidyl-prolyl cis/trans isomerase (trigger factor); Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belongs to the FKBP-type PPIase family. Tig subfamily.


ensembl_gene_id: VF_0796
symbol: clpP
gene_biotype: protein_coding
description:
  Proteolytic subunit of ClpA-ClpP and ClpX-ClpP ATP-dependent serine proteases; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.


ensembl_gene_id: VF_0797
symbol: clpX
gene_biotype: protein_coding
description:
  ATPase and specificity subunit of ClpX-ClpP ATP-dependent serine protease; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.


ensembl_gene_id: VF_0798
symbol: lon
gene_biotype: protein_coding
description:
  DNA-binding ATP-dependent protease Lon (La); ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.


ensembl_gene_id: VF_0799
symbol: hupB
gene_biotype: protein_coding
description:
  HU, DNA-binding transcriptional regulator, beta subunit; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.


ensembl_gene_id: VF_0803
symbol: rfaH
gene_biotype: protein_coding
description:
  DNA-binding transcriptional antiterminator; Enhances distal genes transcription elongation in a specialized subset of operons that encode extracytoplasmic components. Belongs to the RfaH family.


ensembl_gene_id: VF_0805
symbol: VF_0805
gene_biotype: protein_coding
description:
  Glutathione-regulated potassium-efflux system protein KefC; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family.


ensembl_gene_id: VF_0810
symbol: fur
gene_biotype: protein_coding
description:
  DNA-binding transcriptional dual regulator of siderophore biosynthesis and transport; Belongs to the Fur family.


ensembl_gene_id: VF_0812
symbol: fldA
gene_biotype: protein_coding
description:
  Flavodoxin 1; Low-potential electron donor to a number of redox enzymes. Belongs to the flavodoxin family.


ensembl_gene_id: VF_0815
symbol: seqA
gene_biotype: protein_coding
description:
  Regulatory protein for replication initiation; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated.


ensembl_gene_id: VF_0820
symbol: sdhD
gene_biotype: protein_coding
description:
  Succinate dehydrogenase, membrane subunit, binds cytochrome b556; Membrane-anchoring subunit of succinate dehydrogenase (SDH).


ensembl_gene_id: VF_0821
symbol: sdhA
gene_biotype: protein_coding
description:
  Succinate dehydrogenase, flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.


ensembl_gene_id: VF_0822
symbol: sdhB
gene_biotype: protein_coding
description:
  Succinate dehydrogenase, Fe-S subunit; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.


ensembl_gene_id: VF_0824
symbol: sucB
gene_biotype: protein_coding
description:
  Dihydrolipoyltranssuccinase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2).


ensembl_gene_id: VF_0825
symbol: sucC
gene_biotype: protein_coding
description:
  succinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.


ensembl_gene_id: VF_0826
symbol: sucD
gene_biotype: protein_coding
description:
  succinyl-CoA synthetase, NAD(P)-binding, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.


ensembl_gene_id: VF_0829
symbol: znuC
gene_biotype: protein_coding
description:
  Zinc transporter subunit: ATP-binding component of ABC superfamily; Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Zinc importer (TC 3.A.1.15.5) family.


ensembl_gene_id: VF_0830
symbol: znuA
gene_biotype: protein_coding
description:
  Zinc transporter subunit: periplasmic-binding component of ABC superfamily; Belongs to the bacterial solute-binding protein 9 family.


ensembl_gene_id: VF_0834
symbol: feoB
gene_biotype: protein_coding
description:
  Fused ferrous iron transporter, protein B: GTP-binding protein/membrane protein; Probable transporter of a GTP-driven Fe(2+) uptake system. Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.


ensembl_gene_id: VF_0836
symbol: pta
gene_biotype: protein_coding
description:
  Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family.


ensembl_gene_id: VF_0837
symbol: ackA
gene_biotype: protein_coding
description:
  Acetate kinase A and propionate kinase 2; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family.


ensembl_gene_id: VF_0847
symbol: acpP-2
gene_biotype: protein_coding
description:
  Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family.


ensembl_gene_id: VF_0854
symbol: VF_0854
gene_biotype: protein_coding
description:
  Hypothetical protein; Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).


ensembl_gene_id: VF_0857
symbol: VF_0857
gene_biotype: protein_coding
description:
  3-oxoacyl-(acyl carrier protein) synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.


ensembl_gene_id: VF_0862
symbol: rplY
gene_biotype: protein_coding
description:
  50S ribosomal subunit protein L25; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family.


ensembl_gene_id: VF_0874
symbol: secF2
gene_biotype: protein_coding
description:
  Protein translocase subunit SecF-like protein; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.


ensembl_gene_id: VF_0875
symbol: secD2
gene_biotype: protein_coding
description:
  Protein translocase subunit SecD-like protein; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.


ensembl_gene_id: VF_0887
symbol: nhaA
gene_biotype: protein_coding
description:
  Sodium-proton antiporter; Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons; Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.


ensembl_gene_id: VF_0888
symbol: fabV
gene_biotype: protein_coding
description:
  Short-chain alcohol dehydrogenase; Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon- carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP); Belongs to the TER reductase family.


ensembl_gene_id: VF_0892
symbol: panP
gene_biotype: protein_coding
description:
  Glutamate decarboxylase; Catalyzes the pyridoxal-dependent decarboxylation of aspartate to produce beta-alanine. Has weak activity with glutamate. Belongs to the group II decarboxylase family.


ensembl_gene_id: VF_0899
symbol: serC
gene_biotype: protein_coding
description:
  3-phosphoserine/phosphohydroxythreonine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.


ensembl_gene_id: VF_0906
symbol: lolA
gene_biotype: protein_coding
description:
  Lipoprotein chaperone; Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).


ensembl_gene_id: VF_0908
symbol: serS
gene_biotype: protein_coding
description:
  seryl-tRNA synthetase, also charges selenocysteinyl-tRNA with serine; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec).


ensembl_gene_id: VF_0913
symbol: gapA
gene_biotype: protein_coding
description:
  Glyceraldehyde-3-phosphate dehydrogenase A; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.


ensembl_gene_id: VF_0918
symbol: adhE
gene_biotype: protein_coding
description:
  Fused acetaldehyde-CoA dehydrogenase/iron-dependent alcohol dehydrogenase/pyruvate-formate lyase deactivase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.


ensembl_gene_id: VF_0921
symbol: sodB
gene_biotype: protein_coding
description:
  Superoxide dismutase, Fe; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.


ensembl_gene_id: VF_0924
symbol: VF_0924
gene_biotype: protein_coding
description:
  Transport protein; Seems to be involved in glutamine transport. Complements an E. coli glnP deletion mutant.


ensembl_gene_id: VF_0925
symbol: rnt
gene_biotype: protein_coding
description:
  Ribonuclease T (RNase T); Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis.


ensembl_gene_id: VF_0928
symbol: gloA
gene_biotype: protein_coding
description:
  Glyoxalase I, Ni-dependent; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.


ensembl_gene_id: VF_0929
symbol: nth
gene_biotype: protein_coding
description:
  DNA glycosylase and apyrimidinic (AP) lyase (endonuclease III); DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.


ensembl_gene_id: VF_0930
symbol: rnfE
gene_biotype: protein_coding
description:
  NADH-ubiquinone oxidoreductase (Rnf/Rsx reducing system); Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.


ensembl_gene_id: VF_0931
symbol: rnfG
gene_biotype: protein_coding
description:
  Predicted oxidoreductase (Rnf/Rsx reducing system); Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the RnfG family.


ensembl_gene_id: VF_0932
symbol: rnfD
gene_biotype: protein_coding
description:
  Predicted inner membrane oxidoreductase (Rnf/Rsx reducing system); Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the NqrB/RnfD family.


ensembl_gene_id: VF_0933
symbol: rnfC
gene_biotype: protein_coding
description:
  Fused predicted 4Fe-4S ferredoxin-type protein/conserved protein (Rnf/Rsx reducing system); Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.


ensembl_gene_id: VF_0934
symbol: rnfB
gene_biotype: protein_coding
description:
  Predicted iron-sulfur protein (Rnf/Rsx reducing system); Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.


ensembl_gene_id: VF_0935
symbol: rnfA
gene_biotype: protein_coding
description:
  Predicted inner membrane subunit (Rnf/Rsx reducing system); Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.


ensembl_gene_id: VF_0936
symbol: uvrB
gene_biotype: protein_coding
description:
  Excinulease of nucleotide excision repair, DNA damage recognition component; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. I [...]


ensembl_gene_id: VF_0939
symbol: ybhK
gene_biotype: protein_coding
description:
  Predicted transferase with NAD(P)-binding Rossmann-fold domain; Required for morphogenesis under gluconeogenic growth conditions; Belongs to the gluconeogenesis factor family.


ensembl_gene_id: VF_0940
symbol: moaA
gene_biotype: protein_coding
description:
  Molybdopterin biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate.


ensembl_gene_id: VF_0941
symbol: moaC
gene_biotype: protein_coding
description:
  Molybdopterin biosynthesis, protein C; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family.


ensembl_gene_id: VF_0947
symbol: cmoB
gene_biotype: protein_coding
description:
  Predicted S-adenosyl-L-methionine-dependent methyltransferase; Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L- methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5- carboxymethoxyuridine (cmo5U) at position 34 in tRNAs.


ensembl_gene_id: VF_0948
symbol: cmoA
gene_biotype: protein_coding
description:
  Methyltransferase; Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM).


ensembl_gene_id: VF_0949
symbol: aspS
gene_biotype: protein_coding
description:
  aspartyl-tRNA synthetase; Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp- AMP and then transferred to the acceptor end of tRNA(Asp). Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.


ensembl_gene_id: VF_0950
symbol: ruvC
gene_biotype: protein_coding
description:
  Component of RuvABC resolvasome, endonuclease; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.


ensembl_gene_id: VF_0951
symbol: ruvA
gene_biotype: protein_coding
description:
  Component of RuvABC resolvasome, regulatory subunit; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.


ensembl_gene_id: VF_0952
symbol: ruvB
gene_biotype: protein_coding
description:
  ATP-dependent DNA helicase, component of RuvABC resolvasome; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.


ensembl_gene_id: VF_0958
symbol: tolQ
gene_biotype: protein_coding
description:
  Membrane spanning protein in TolA-TolQ-TolR complex; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.


ensembl_gene_id: VF_0962
symbol: tolB
gene_biotype: protein_coding
description:
  Periplasmic protein TolB; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.


ensembl_gene_id: VF_0963
symbol: pal
gene_biotype: protein_coding
description:
  Peptidoglycan-associated outer membrane lipoprotein; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.


ensembl_gene_id: VF_0964
symbol: ybgF
gene_biotype: protein_coding
description:
  Predicted protein; Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division; Belongs to the CpoB family.


ensembl_gene_id: VF_0965
symbol: nadA
gene_biotype: protein_coding
description:
  Quinolinate synthase, subunit A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate; Belongs to the quinolinate synthase A family. Type 1 subfamily.


ensembl_gene_id: VF_0971
symbol: hflX-2
gene_biotype: protein_coding
description:
  GTP-binding protein HflX; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.


ensembl_gene_id: VF_0973
symbol: gshA2
gene_biotype: protein_coding
description:
  Glutamate--cysteine ligase; Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily.


ensembl_gene_id: VF_1012
symbol: hisG
gene_biotype: protein_coding
description:
  ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily.


ensembl_gene_id: VF_1013
symbol: hisD
gene_biotype: protein_coding
description:
  Bifunctional histidinal dehydrogenase/ histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.


ensembl_gene_id: VF_1014
symbol: hisC
gene_biotype: protein_coding
description:
  Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.


ensembl_gene_id: VF_1015
symbol: hisB
gene_biotype: protein_coding
description:
  Fused histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase; In the N-terminal section; belongs to the histidinol- phosphatase family.


ensembl_gene_id: VF_1016
symbol: hisH
gene_biotype: protein_coding
description:
  Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit with HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.


ensembl_gene_id: VF_1018
symbol: hisF
gene_biotype: protein_coding
description:
  Imidazole glycerol phosphate synthase, catalytic subunit with HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.


ensembl_gene_id: VF_1019
symbol: hisI
gene_biotype: protein_coding
description:
  Fused phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase; In the N-terminal section; belongs to the PRA-CH family.


ensembl_gene_id: VF_1025
symbol: yciB
gene_biotype: protein_coding
description:
  Predicted inner membrane protein; Involved in cell division; probably involved in intracellular septation; Belongs to the YciB family.


ensembl_gene_id: VF_1026
symbol: gltP
gene_biotype: protein_coding
description:
  Glutamate/aspartate:proton symporter; Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.


ensembl_gene_id: VF_1027
symbol: trpA
gene_biotype: protein_coding
description:
  Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.


ensembl_gene_id: VF_1028
symbol: trpB
gene_biotype: protein_coding
description:
  Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.


ensembl_gene_id: VF_1029
symbol: trpC
gene_biotype: protein_coding
description:
  Fused indole-3-glycerolphosphate synthetase/N-(5-phosphoribosyl)anthranilate isomerase; Belongs to the TrpC family.


ensembl_gene_id: VF_1031
symbol: trpG
gene_biotype: protein_coding
description:
  Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA).


ensembl_gene_id: VF_1051
symbol: topA
gene_biotype: protein_coding
description:
  DNA topoisomerase I, omega subunit; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus re [...]


ensembl_gene_id: VF_1055
symbol: ldhA
gene_biotype: protein_coding
description:
  Fermentative D-lactate dehydrogenase, NAD-dependent; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.


ensembl_gene_id: VF_1060
symbol: VF_1060
gene_biotype: protein_coding
description:
  Peptidase T; Cleaves the N-terminal amino acid of tripeptides. Belongs to the peptidase M20B family.


ensembl_gene_id: VF_1062
symbol: purA-2
gene_biotype: protein_coding
description:
  Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.


ensembl_gene_id: VF_1064
symbol: gadA
gene_biotype: protein_coding
description:
  Glutamate decarboxylase A, PLP-dependent; Catalyzes the pyridoxal-dependent decarboxylation of glutamate to produce 4-aminobutanoate. Has weak activity with aspartate, but cannot complement an E. coli panD deletion mutant. Belongs to the group II decarboxylase family.


ensembl_gene_id: VF_1084
symbol: VF_1084
gene_biotype: protein_coding
description:
  Branched-chain amino acid transport system II carrier protein; Component of the transport system for branched-chain amino acids.


ensembl_gene_id: VF_1088
symbol: VF_1088
gene_biotype: protein_coding
description:
  Anaerobic C4-dicarboxylate transporter; Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane; Belongs to the DcuA/DcuB transporter (TC 2.A.13.1) family.


ensembl_gene_id: VF_1096
symbol: VF_1096
gene_biotype: protein_coding
description:
  Nucleoside permease NupC; Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.


ensembl_gene_id: VF_1114
symbol: murQ
gene_biotype: protein_coding
description:
  Predicted PTS component; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling.


ensembl_gene_id: VF_1115
symbol: murP
gene_biotype: protein_coding
description:
  Fused predicted PTS enzymes: IIB component/IIC component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylmuramic acid (MurNAc) transport, yielding cytoplasmic MurNAc-6-P. Is also able to take up anhydro-N-acetylmuramic acid (anhMurNAc), but cannot phosphorylate the carbon 6, probably because of the 1,6-anhydro ring.


ensembl_gene_id: VF_1124
symbol: yhiP
gene_biotype: protein_coding
description:
  Predicted transporter; Proton-dependent permease that transports di- and tripeptides; Belongs to the PTR2/POT transporter (TC 2.A.17) family. DtpB subfamily.


ensembl_gene_id: VF_1155
symbol: VF_1155
gene_biotype: protein_coding
description:
  Proton glutamate symport protein; Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.


ensembl_gene_id: VF_1161
symbol: VF_1161
gene_biotype: protein_coding
description:
  Periplasmic component of efflux system; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.


ensembl_gene_id: VF_1167
symbol: sbcD
gene_biotype: protein_coding
description:
  Exonuclease, dsDNA, ATP-dependent; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family.


ensembl_gene_id: VF_1172
symbol: VF_1172
gene_biotype: protein_coding
description:
  Tyrosine-specific transport protein; Seems to be involved in glutamine transport. Complements an E. coli glnP deletion mutant; Belongs to the amino acid/polyamine transporter 2 family.


ensembl_gene_id: VF_1180
symbol: fumB
gene_biotype: protein_coding
description:
  Anaerobic class I fumarate hydratase (fumarase B); Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.


ensembl_gene_id: VF_1182
symbol: VF_1182
gene_biotype: protein_coding
description:
  Acriflavin resistance periplasmic protein; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.


ensembl_gene_id: VF_1189
symbol: ribA
gene_biotype: protein_coding
description:
  GTP cyclohydrolase II; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family.


ensembl_gene_id: VF_1202
symbol: nrdA
gene_biotype: protein_coding
description:
  Ribonucleoside diphosphate reductase 1, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.


ensembl_gene_id: VF_1203
symbol: ubiG
gene_biotype: protein_coding
description:
  Bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the methyltransferase superfamily. UbiG/COQ3 family.


ensembl_gene_id: VF_1204
symbol: gyrA
gene_biotype: protein_coding
description:
  DNA gyrase (type II topoisomerase), subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP [...]


ensembl_gene_id: VF_1214
symbol: thrS
gene_biotype: protein_coding
description:
  threonyl-tRNA synthetase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr).


ensembl_gene_id: VF_1216
symbol: infC
gene_biotype: protein_coding
description:
  Protein chain initiation factor IF-3; IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.


ensembl_gene_id: VF_1218
symbol: rplT
gene_biotype: protein_coding
description:
  50S ribosomal subunit protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.


ensembl_gene_id: VF_1220
symbol: hmuV
gene_biotype: protein_coding
description:
  Hemin import ATP-binding protein HmuV; Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system.


ensembl_gene_id: VF_1221
symbol: hmuU
gene_biotype: protein_coding
description:
  Hemin transport system permease protein HmuU; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.


ensembl_gene_id: VF_1235
symbol: pheS
gene_biotype: protein_coding
description:
  Phenylalanine tRNA synthetase, alpha subunit; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.


ensembl_gene_id: VF_1236
symbol: pheT
gene_biotype: protein_coding
description:
  Phenylalanine tRNA synthetase, beta subunit; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.


ensembl_gene_id: VF_1237
symbol: ihfA
gene_biotype: protein_coding
description:
  Integration host factor (IHF), DNA-binding protein, alpha subunit; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family.


ensembl_gene_id: VF_1238
symbol: astE
gene_biotype: protein_coding
description:
  Succinylglutamate desuccinylase; Transforms N(2)-succinylglutamate into succinate and glutamate; Belongs to the AspA/AstE family. Succinylglutamate desuccinylase subfamily.


ensembl_gene_id: VF_1241
symbol: aroH
gene_biotype: protein_coding
description:
  3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, tryptophan repressible; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP).


ensembl_gene_id: VF_1269
symbol: umuD
gene_biotype: protein_coding
description:
  nucleotidyltransferase/DNA polymerase V subunit C involved in DNA repair, amber nonsense codon and 5 bp minisatellite insertion to create pseudogene; Belongs to the peptidase S24 family.


ensembl_gene_id: VF_1274
symbol: rsmF
gene_biotype: protein_coding
description:
  Predicted methyltransferase; Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA.


ensembl_gene_id: VF_1279
symbol: proQ
gene_biotype: protein_coding
description:
  Predicted structural transport element; RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities; Belongs to the ProQ family.


ensembl_gene_id: VF_1285
symbol: pyrD
gene_biotype: protein_coding
description:
  Dihydro-orotate oxidase, FMN-linked; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.


ensembl_gene_id: VF_1286
symbol: ycbW
gene_biotype: protein_coding
description:
  Predicted protein; Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ.


ensembl_gene_id: VF_1287
symbol: rlmL
gene_biotype: protein_coding
description:
  Predicted methyltransferase; Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA. Belongs to the methyltransferase superfamily. RlmKL family.


ensembl_gene_id: VF_1291
symbol: rmf
gene_biotype: protein_coding
description:
  Ribosome modulation factor; During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes); Belongs to the ribosome modulation factor family.


ensembl_gene_id: VF_1292
symbol: fabA
gene_biotype: protein_coding
description:
  Beta-hydroxydecanoyl thioester dehydrase; Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E- (2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length.


ensembl_gene_id: VF_1294
symbol: ycbG
gene_biotype: protein_coding
description:
  Conserved protein; Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain.


ensembl_gene_id: VF_1302
symbol: ccoP
gene_biotype: protein_coding
description:
  Cytochrome c oxidase, cbb3-type, subunit III; C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex.


ensembl_gene_id: VF_1311
symbol: ttcA
gene_biotype: protein_coding
description:
  Predicted C32 tRNA thiolase; Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.


ensembl_gene_id: VF_1315
symbol: potA
gene_biotype: protein_coding
description:
  Polyamine transporter ATPase protein; Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.


ensembl_gene_id: VF_1318
symbol: potD2
gene_biotype: protein_coding
description:
  Polyamine transporter binding protein; Required for the activity of the bacterial periplasmic transport system of putrescine; Belongs to the bacterial solute-binding protein PotD/PotF family.


ensembl_gene_id: VF_1320
symbol: cobB
gene_biotype: protein_coding
description:
  Deacetylase of acetyl-CoA synthetase, NAD-dependent; Belongs to the sirtuin family. Class III subfamily.


ensembl_gene_id: VF_1360
symbol: fdnG
gene_biotype: protein_coding
description:
  Formate dehydrogenase N, alpha subunit; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.


ensembl_gene_id: VF_1366
symbol: fdhD
gene_biotype: protein_coding
description:
  FdhD protein (FdsC); Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Belongs to the FdhD family.


ensembl_gene_id: VF_1368
symbol: VF_1368
gene_biotype: protein_coding
description:
  Membrane-bound lytic murein transglycosylase C precursor; Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division.


ensembl_gene_id: VF_1370
symbol: pcp
gene_biotype: protein_coding
description:
  Pyrrolidone-carboxylate peptidase; Removes 5-oxoproline from various penultimate amino acid residues except L-proline; Belongs to the peptidase C15 family.


ensembl_gene_id: VF_1376
symbol: ybgL
gene_biotype: protein_coding
description:
  Predicted lactam utilization protein; Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.


ensembl_gene_id: VF_1405
symbol: mobA
gene_biotype: protein_coding
description:
  Molybdopterin-guanine dinucleotide synthase; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor; Belongs to the MobA family.


ensembl_gene_id: VF_1406
symbol: mobB
gene_biotype: protein_coding
description:
  Molybdopterin-guanine dinucleotide biosynthesis protein B; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family.


ensembl_gene_id: VF_1408
symbol: nagK
gene_biotype: protein_coding
description:
  N-acetyl-D-glucosamine kinase; Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P.


ensembl_gene_id: VF_1415
symbol: mdtK
gene_biotype: protein_coding
description:
  Multidrug efflux system transporter; Multidrug efflux pump that functions as a Na(+)/drug antiporter; Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.


ensembl_gene_id: VF_1444
symbol: rbsD
gene_biotype: protein_coding
description:
  High affinity ribose transport protein RbsD; Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.


ensembl_gene_id: VF_1445
symbol: rbsA
gene_biotype: protein_coding
description:
  Ribose transport ATP-binding protein RbsA; Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Ribose importer (TC 3.A.1.2.1) family.


ensembl_gene_id: VF_1446
symbol: rbsC
gene_biotype: protein_coding
description:
  Ribose transport system permease protein RbsC; Belongs to the binding-protein-dependent transport system permease family.


ensembl_gene_id: VF_1448
symbol: rbsK
gene_biotype: protein_coding
description:
  Ribokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.


ensembl_gene_id: VF_1457
symbol: VF_1457
gene_biotype: protein_coding
description:
  Thermostable carboxypeptidase 1; Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues.


ensembl_gene_id: VF_1479
symbol: aqpZ
gene_biotype: protein_coding
description:
  Aquaporin; Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity; Belongs to the MIP/aquaporin (TC 1.A.8) family.


ensembl_gene_id: VF_1481
symbol: mrdA-2
gene_biotype: protein_coding
description:
  Penicillin binding protein transpeptidase; Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily.


ensembl_gene_id: VF_1485
symbol: cdd
gene_biotype: protein_coding
description:
  Cytidine/deoxycytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.


ensembl_gene_id: VF_1487
symbol: purT
gene_biotype: protein_coding
description:
  Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family.


ensembl_gene_id: VF_1490
symbol: cysB
gene_biotype: protein_coding
description:
  DNA-binding transcriptional dual regulator, O-acetyl-L-serine-binding; Belongs to the LysR transcriptional regulatory family.


ensembl_gene_id: VF_1509
symbol: iadA
gene_biotype: protein_coding
description:
  Isoaspartyl dipeptidase; Catalyzes the hydrolytic cleavage of a subset of L- isoaspartyl (L-beta-aspartyl) dipeptides. Used to degrade proteins damaged by L-isoaspartyl residues formation.


ensembl_gene_id: VF_1512
symbol: tpm
gene_biotype: protein_coding
description:
  Thiopurine S-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.


ensembl_gene_id: VF_1513
symbol: ydjN
gene_biotype: protein_coding
description:
  Predicted transporter; Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.


ensembl_gene_id: VF_1521
symbol: udp
gene_biotype: protein_coding
description:
  Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the PNP/UDP phosphorylase family.


ensembl_gene_id: VF_1548
symbol: nrfF
gene_biotype: protein_coding
description:
  Heme lyase (NrfEFG) for insertion of heme into c552, subunit NrfF; Possible subunit of a heme lyase.


ensembl_gene_id: VF_1554
symbol: nfrA
gene_biotype: protein_coding
description:
  Nitrite reductase, formate-dependent, cytochrome; Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process; Belongs to the cytochrome c-552 family.


ensembl_gene_id: VF_1556
symbol: pldA
gene_biotype: protein_coding
description:
  Outer membrane phospholipase A; Hydrolysis of phosphatidylcholine with phospholipase A2 (EC 3.1.1.4) and phospholipase A1 (EC 3.1.1.32) activities. Belongs to the phospholipase A1 family.


ensembl_gene_id: VF_1558
symbol: maeA
gene_biotype: protein_coding
description:
  Malate dehydrogenase, (decarboxylating, NAD-requiring) (malic enzyme); Belongs to the malic enzymes family.


ensembl_gene_id: VF_1571
symbol: torD
gene_biotype: protein_coding
description:
  Chaperone involved in maturation of TorA subunit of trimethylamine N-oxide reductase system I; Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor; Belongs to the TorD/DmsD family. TorD subfamily.


ensembl_gene_id: VF_1572
symbol: purR
gene_biotype: protein_coding
description:
  DNA-binding transcriptional repressor, hypoxanthine-binding; Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression.


ensembl_gene_id: VF_1573
symbol: tfoX2
gene_biotype: protein_coding
description:
  DNA transformation protein TfoX2 (Sxy); Required for efficient DNA transformation jointly with TfoX1. Belongs to the TfoX family.


ensembl_gene_id: VF_1580
symbol: queC
gene_biotype: protein_coding
description:
  Queuosine biosynthesis protein QueC; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family.


ensembl_gene_id: VF_1587
symbol: argT
gene_biotype: protein_coding
description:
  Lysine/arginine/ornithine transporter subunit; Belongs to the bacterial solute-binding protein 3 family.


ensembl_gene_id: VF_1591
symbol: pflA
gene_biotype: protein_coding
description:
  Pyruvate formate lyase activating enzyme 1; Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family.


ensembl_gene_id: VF_1601
symbol: ppiB
gene_biotype: protein_coding
description:
  Peptidyl-prolyl cis-trans isomerase B (rotamase B); PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.


ensembl_gene_id: VF_1602
symbol: lpxH
gene_biotype: protein_coding
description:
  UDP-2,3-diacylglucosamine pyrophosphatase; Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.


ensembl_gene_id: VF_1606
symbol: cls
gene_biotype: protein_coding
description:
  Cardiolipin synthase 1; Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.


ensembl_gene_id: VF_1608
symbol: moeA
gene_biotype: protein_coding
description:
  Molybdopterin biosynthesis protein; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family.


ensembl_gene_id: VF_1611
symbol: pstC2
gene_biotype: protein_coding
description:
  Phosphate ABC transporter, permease protein PstC; Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.


ensembl_gene_id: VF_1613
symbol: pstB2
gene_biotype: protein_coding
description:
  Phosphate transport ATP-binding protein PstB; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.


ensembl_gene_id: VF_1625
symbol: pgsA
gene_biotype: protein_coding
description:
  Phosphatidylglycerophosphate synthetase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.


ensembl_gene_id: VF_1626
symbol: uvrC
gene_biotype: protein_coding
description:
  Excinuclease UvrABC, endonuclease subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.


ensembl_gene_id: VF_1633
symbol: fadR
gene_biotype: protein_coding
description:
  DNA-binding transcriptional dual regulator of fatty acid metabolism; Multifunctional regulator of fatty acid metabolism.


ensembl_gene_id: VF_1634
symbol: nhaB
gene_biotype: protein_coding
description:
  Sodium:proton antiporter; Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons; Belongs to the NhaB Na(+)/H(+) (TC 2.A.34) antiporter family.


ensembl_gene_id: VF_1635
symbol: dsbB
gene_biotype: protein_coding
description:
  Oxidoreductase that catalyzes reoxidation of DsbA protein disulfide isomerase I; Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein; Belongs to the DsbB family.


ensembl_gene_id: VF_1638
symbol: dusC
gene_biotype: protein_coding
description:
  tRNA-dihydrouridine synthase C; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U16 in tRNAs. Belongs to the Dus family. DusC subfamily.


ensembl_gene_id: VF_1641
symbol: topB
gene_biotype: protein_coding
description:
  DNA topoisomerase III; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA su [...]


ensembl_gene_id: VF_1645
symbol: asd
gene_biotype: protein_coding
description:
  Aspartate-semialdehyde dehydrogenase, NAD(P)-binding; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family.


ensembl_gene_id: VF_1667
symbol: menC
gene_biotype: protein_coding
description:
  o-succinylbenzoyl-CoA synthase; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB).


ensembl_gene_id: VF_1669
symbol: menB
gene_biotype: protein_coding
description:
  Dihydroxynaphthoic acid synthetase; Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA).


ensembl_gene_id: VF_1670
symbol: yfbB
gene_biotype: protein_coding
description:
  Predicted peptidase; Catalyzes a proton abstraction reaction that results in 2,5- elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6- hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC).


ensembl_gene_id: VF_1671
symbol: menD
gene_biotype: protein_coding
description:
  Bifunctional 2-oxoglutarate decarboxylase/ SHCHC synthase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).


ensembl_gene_id: VF_1685
symbol: recR
gene_biotype: protein_coding
description:
  Gap repair protein; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.


ensembl_gene_id: VF_1686
symbol: ybaB
gene_biotype: protein_coding
description:
  Conserved protein; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.


ensembl_gene_id: VF_1687
symbol: dnaX
gene_biotype: protein_coding
description:
  DNA polymerase III/DNA elongation factor III, tau and gamma subunits; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.


ensembl_gene_id: VF_1688
symbol: apt
gene_biotype: protein_coding
description:
  Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.


ensembl_gene_id: VF_1691
symbol: purF
gene_biotype: protein_coding
description:
  Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.


ensembl_gene_id: VF_1694
symbol: folC
gene_biotype: protein_coding
description:
  Bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Belongs to the folylpolyglutamate synthase family.


ensembl_gene_id: VF_1695
symbol: accD
gene_biotype: protein_coding
description:
  acetyl-CoA carboxylase, beta (carboxyltranferase) subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family.


ensembl_gene_id: VF_1696
symbol: truA
gene_biotype: protein_coding
description:
  Pseudouridylate synthase I; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.


ensembl_gene_id: VF_1698
symbol: usg
gene_biotype: protein_coding
description:
  Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family.


ensembl_gene_id: VF_1699
symbol: pdxB
gene_biotype: protein_coding
description:
  Erythronate-4-phosphate dehydrogenase; Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate.


ensembl_gene_id: VF_1700
symbol: fabB
gene_biotype: protein_coding
description:
  3-oxoacyl-(acyl-carrier-protein)-synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.


ensembl_gene_id: VF_1701
symbol: mnmC
gene_biotype: protein_coding
description:
  tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC; Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34; In the N-terminal section; belongs to the methyltransferase superfamily. tRNA (mnm(5)s(2)U34)-methyltransferase family.


ensembl_gene_id: VF_1704
symbol: minC
gene_biotype: protein_coding
description:
  Septum inhibitor protein of the MinC-MinD-MinE system; Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization; Belongs to the MinC family.


ensembl_gene_id: VF_1706
symbol: minE
gene_biotype: protein_coding
description:
  Cell division topological specificity factor of the MinC-MinD-MinE system; Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell.


ensembl_gene_id: VF_1707
symbol: rnd
gene_biotype: protein_coding
description:
  Ribonuclease D; Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides; Belongs to the RNase D family.


ensembl_gene_id: VF_1721
symbol: metE
gene_biotype: protein_coding
description:
  5-methyltetrahydropteroyltriglutamate- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.


ensembl_gene_id: VF_1722
symbol: metR
gene_biotype: protein_coding
description:
  DNA-binding transcriptional activator, homocysteine-binding; Belongs to the LysR transcriptional regulatory family.


ensembl_gene_id: VF_1727
symbol: tyrS
gene_biotype: protein_coding
description:
  tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.


ensembl_gene_id: VF_1730
symbol: VF_1730
gene_biotype: protein_coding
description:
  Sodium/proline symporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.


ensembl_gene_id: VF_1735
symbol: tmk
gene_biotype: protein_coding
description:
  Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.


ensembl_gene_id: VF_1736
symbol: yceG
gene_biotype: protein_coding
description:
  Predicted aminodeoxychorismate lyase; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.


ensembl_gene_id: VF_1738
symbol: fabF
gene_biotype: protein_coding
description:
  3-oxoacyl-(acyl-carrier-protein) synthase; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.


ensembl_gene_id: VF_1740
symbol: fabG
gene_biotype: protein_coding
description:
  3-oxoacyl-(acyl-carrier-protein) reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family.


ensembl_gene_id: VF_1742
symbol: fabH
gene_biotype: protein_coding
description:
  3-oxoacyl-(acyl carrier protein) synthase; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family.


ensembl_gene_id: VF_1743
symbol: plsX
gene_biotype: protein_coding
description:
  Fatty acid/phospholipid synthesis protein; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.


ensembl_gene_id: VF_1746
symbol: yceF
gene_biotype: protein_coding
description:
  Predicted protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes 7- methyl-GTP (m(7)GTP). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids; Belongs to the Maf family. YceF subfamily.


ensembl_gene_id: VF_1747
symbol: rluC
gene_biotype: protein_coding
description:
  23S rRNA pseudouridylate synthase; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family.


ensembl_gene_id: VF_1748
symbol: rne
gene_biotype: protein_coding
description:
  Rne; Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs. Belongs to the RNase E/G family. RNase E subfamily.


ensembl_gene_id: VF_1750
symbol: btuR
gene_biotype: protein_coding
description:
  cob(I)alamin adenolsyltransferase/cobinamide ATP-dependent adenolsyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids.


ensembl_gene_id: VF_1753
symbol: mrp
gene_biotype: protein_coding
description:
  Antiporter inner membrane protein; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family.


ensembl_gene_id: VF_1754
symbol: metG
gene_biotype: protein_coding
description:
  methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.


ensembl_gene_id: VF_1755
symbol: pyrF
gene_biotype: protein_coding
description:
  Orotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily.


ensembl_gene_id: VF_1756
symbol: yciM
gene_biotype: protein_coding
description:
  Conserved protein; Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane; Belongs to the LapB family.


ensembl_gene_id: VF_1757
symbol: lapA
gene_biotype: protein_coding
description:
  Hypothetical protein; Involved in the assembly of lipopolysaccharide (LPS). Belongs to the LapA family.


ensembl_gene_id: VF_1758
symbol: ihfB
gene_biotype: protein_coding
description:
  Integration host factor (IHF), DNA-binding protein, beta subunit; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family.


ensembl_gene_id: VF_1759
symbol: rpsA
gene_biotype: protein_coding
description:
  30S ribosomal subunit protein S1; Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence.


ensembl_gene_id: VF_1761
symbol: aroA
gene_biotype: protein_coding
description:
  5-enolpyruvylshikimate-3-phosphate synthetase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.


ensembl_gene_id: VF_1762
symbol: aat
gene_biotype: protein_coding
description:
  leucyl/phenylalanyl-tRNA-protein transferase; Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl- tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.


ensembl_gene_id: VF_1763
symbol: bpt
gene_biotype: protein_coding
description:
  arginine-tRNA-protein transferase; Functions in the N-end rule pathway of protein degradation where it conjugates Leu from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate. Belongs to the R-transferase family. Bpt subfamily.


ensembl_gene_id: VF_1764
symbol: infA
gene_biotype: protein_coding
description:
  Translation initiation factor IF-1; One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.


ensembl_gene_id: VF_1765
symbol: clpA
gene_biotype: protein_coding
description:
  ATPase and specificity subunit of ClpA-ClpP ATP-dependent serine protease, chaperone activity; Belongs to the ClpA/ClpB family.


ensembl_gene_id: VF_1766
symbol: clpS
gene_biotype: protein_coding
description:
  Specificity factor for ClpA-ClpP chaperone-protease complex; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family.


ensembl_gene_id: VF_1769
symbol: ydiU
gene_biotype: protein_coding
description:
  Conserved protein; Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).


ensembl_gene_id: VF_1770
symbol: folD
gene_biotype: protein_coding
description:
  Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.


ensembl_gene_id: VF_1781
symbol: norW
gene_biotype: protein_coding
description:
  NADH:flavorubredoxin oxidoreductase; One of at least two accessory proteins for anaerobic nitric oxide (NO) reductase. Reduces the rubredoxin moiety of NO reductase.


ensembl_gene_id: VF_1782
symbol: norV
gene_biotype: protein_coding
description:
  Flavorubredoxin oxidoreductase; Anaerobic nitric oxide reductase; uses NADH to detoxify nitric oxide (NO), protecting several 4Fe-4S NO-sensitive enzymes. Has at least 2 reductase partners, only one of which (NorW, flavorubredoxin reductase) has been identified. NO probably binds to the di-iron center; electrons enter from the NorW at rubredoxin and are transferred sequentially to the FMN center and the di-iron center. Also able to function as an aerobic oxygen reductase; In the N-terminal section; belongs to the zinc metallo- hydrolase group 3 family.


ensembl_gene_id: VF_1783
symbol: norR1
gene_biotype: protein_coding
description:
  Anaerobic nitric oxide reductase regulator; Required for the expression of anaerobic nitric oxide (NO) reductase, acts as a transcriptional activator for at least the norVW operon. Activation also requires sigma-54.


ensembl_gene_id: VF_1784
symbol: mnmA
gene_biotype: protein_coding
description:
  tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.


ensembl_gene_id: VF_1799
symbol: msbB
gene_biotype: protein_coding
description:
  Myristoyl-acyl carrier protein (ACP)-dependent acyltransferase (MsbB, LpxM); Catalyzes the transfer of myristate from myristoyl-acyl carrier protein (ACP) to Kdo(2)-(lauroyl)-lipid IV(A) to form Kdo(2)- lipid A.


ensembl_gene_id: VF_1805
symbol: aroC
gene_biotype: protein_coding
description:
  Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.


ensembl_gene_id: VF_1806
symbol: prmB
gene_biotype: protein_coding
description:
  N5-glutamine methyltransferase; Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue; Belongs to the protein N5-glutamine methyltransferase family. PrmB subfamily.


ensembl_gene_id: VF_1810
symbol: fadJ
gene_biotype: protein_coding
description:
  Fused enoyl-CoA hydratase and epimerase and isomerase/3-hydroxyacyl-CoA dehydrogenase; Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3- hydroxyacyl-CoA dehydrogenase activities; In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.


ensembl_gene_id: VF_1811
symbol: fadI
gene_biotype: protein_coding
description:
  beta-ketoacyl-CoA thiolase, anaerobic, subunit; Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.


ensembl_gene_id: VF_1820
symbol: ccmE
gene_biotype: protein_coding
description:
  Periplasmic heme chaperone; Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH. Belongs to the CcmE/CycJ family.


ensembl_gene_id: VF_1821
symbol: ccmD
gene_biotype: protein_coding
description:
  Heme exporter protein D; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmD/CycX/HelD family.


ensembl_gene_id: VF_1822
symbol: ccmC
gene_biotype: protein_coding
description:
  Heme exporter subunit C; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmC/CycZ/HelC family.


ensembl_gene_id: VF_1823
symbol: ccmB
gene_biotype: protein_coding
description:
  Heme exporter subunit B; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmB/CycW/HelB family.


ensembl_gene_id: VF_1824
symbol: ccmA
gene_biotype: protein_coding
description:
  Heme exporter subunit A; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family.


ensembl_gene_id: VF_1830
symbol: cheB
gene_biotype: protein_coding
description:
  Chemotaxis response regulator protein-glutamate methylesterase CheB; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family.


ensembl_gene_id: VF_1832
symbol: cheZ
gene_biotype: protein_coding
description:
  Chemotaxis regulator CheZ, protein phosphatase for CheY; Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P).


ensembl_gene_id: VF_1834
symbol: fliA
gene_biotype: protein_coding
description:
  RNA polymerase, sigma-28 (sigma-F, FliA) factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes; Belongs to the sigma-70 factor family. FliA subfamily.


ensembl_gene_id: VF_1837
symbol: flhA
gene_biotype: protein_coding
description:
  Flagellar export pore protein FlhA; Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin; Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.


ensembl_gene_id: VF_1839
symbol: flhB
gene_biotype: protein_coding
description:
  Flagellar export pore protein FlhB; Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin; Belongs to the type III secretion exporter family.


ensembl_gene_id: VF_1840
symbol: fliR
gene_biotype: protein_coding
description:
  Flagellar export pore protein FliR; Role in flagellar biosynthesis. Belongs to the FliR/MopE/SpaR family.


ensembl_gene_id: VF_1841
symbol: fliQ
gene_biotype: protein_coding
description:
  Flagellar biosynthesis protein FliQ; Role in flagellar biosynthesis. Belongs to the FliQ/MopD/SpaQ family.


ensembl_gene_id: VF_1842
symbol: fliP
gene_biotype: protein_coding
description:
  Flagellar biosynthesis protein FliP; Plays a role in the flagellum-specific transport system. Belongs to the FliP/MopC/SpaP family.


ensembl_gene_id: VF_1844
symbol: fliN
gene_biotype: protein_coding
description:
  Flagellar motor switch component FliN; FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation. Belongs to the FliN/MopA/SpaO family.


ensembl_gene_id: VF_1845
symbol: fliM
gene_biotype: protein_coding
description:
  Flagellar motor switch protein FliM; FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.


ensembl_gene_id: VF_1846
symbol: fliL1
gene_biotype: protein_coding
description:
  Flagellar basal body-associated protein FliL1; Controls the rotational direction of flagella during chemotaxis; Belongs to the FliL family.


ensembl_gene_id: VF_1851
symbol: fliG
gene_biotype: protein_coding
description:
  Flagellar motor switch protein FliG; FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.


ensembl_gene_id: VF_1852
symbol: fliF
gene_biotype: protein_coding
description:
  Flagellar M ring protein FliF; The M ring may be actively involved in energy transduction. Belongs to the FliF family.


ensembl_gene_id: VF_1860
symbol: fliD
gene_biotype: protein_coding
description:
  Flagellar hook-associated protein 2, FliD; Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.


ensembl_gene_id: VF_1862
symbol: flaE
gene_biotype: protein_coding
description:
  Flagellin FlaE; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.


ensembl_gene_id: VF_1863
symbol: flaD
gene_biotype: protein_coding
description:
  Flagellin FlaD; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.


ensembl_gene_id: VF_1864
symbol: flaC
gene_biotype: protein_coding
description:
  Flagellin FlaC; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.


ensembl_gene_id: VF_1865
symbol: flaB
gene_biotype: protein_coding
description:
  Flagellin FlaB; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.


ensembl_gene_id: VF_1866
symbol: flaA
gene_biotype: protein_coding
description:
  Flagellin FlaA; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.


ensembl_gene_id: VF_1870
symbol: flgI
gene_biotype: protein_coding
description:
  Flagellar basal body P ring protein flgI; Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


ensembl_gene_id: VF_1871
symbol: flgH
gene_biotype: protein_coding
description:
  Flagellar basal body L ring protein FlgH; Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.


ensembl_gene_id: VF_1875
symbol: flgD
gene_biotype: protein_coding
description:
  Flagellar hook capping protein FlgD; Required for flagellar hook formation. May act as a scaffolding protein.


ensembl_gene_id: VF_1877
symbol: flgB
gene_biotype: protein_coding
description:
  Flagellar proximal rod protein FlgB; Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.


ensembl_gene_id: VF_1887
symbol: gltX
gene_biotype: protein_coding
description:
  glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.


ensembl_gene_id: VF_1890
symbol: ligA
gene_biotype: protein_coding
description:
  DNA ligase, NAD(+)-dependent; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.


ensembl_gene_id: VF_1891
symbol: zipA
gene_biotype: protein_coding
description:
  Cell division protein involved in Z ring assembly; Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins.


ensembl_gene_id: VF_1892
symbol: cysZ
gene_biotype: protein_coding
description:
  Predicted inner membrane protein; High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway; Belongs to the CysZ family.


ensembl_gene_id: VF_1893
symbol: cysK
gene_biotype: protein_coding
description:
  Cysteine synthase A, O-acetylserine sulfhydrolase A subunit; Belongs to the cysteine synthase/cystathionine beta- synthase family.


ensembl_gene_id: VF_1895
symbol: ptsI
gene_biotype: protein_coding
description:
  PEP-protein phosphotransferase of PTS system (enzyme I); General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).


ensembl_gene_id: VF_1904
symbol: napB
gene_biotype: protein_coding
description:
  Nitrate reductase, small, cytochrome C550 subunit, periplasmic; Electron transfer subunit of the periplasmic nitrate reductase complex NapAB; Belongs to the NapB family.


ensembl_gene_id: VF_1905
symbol: napA
gene_biotype: protein_coding
description:
  Nitrate reductase, large, cytochrome C550 subunit, periplasmic; Catalytic subunit of the periplasmic nitrate reductase complex NapAB. Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite.


ensembl_gene_id: VF_1906
symbol: napD
gene_biotype: protein_coding
description:
  Protein required for assembly of periplasmic nitrate reductase (NapA); Chaperone for NapA, the catalytic subunit of the periplasmic nitrate reductase. It binds directly and specifically to the twin- arginine signal peptide of NapA, preventing premature interaction with the Tat translocase and premature export.


ensembl_gene_id: VF_1907
symbol: napF
gene_biotype: protein_coding
description:
  Ferredoxin-type protein NapF; Could be involved in the maturation of NapA, the catalytic subunit of the periplasmic nitrate reductase, before its export into the periplasm; Belongs to the NapF family.


ensembl_gene_id: VF_1914
symbol: dapE
gene_biotype: protein_coding
description:
  N-succinyl-diaminopimelate deacylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily.


ensembl_gene_id: VF_1917
symbol: nlpB
gene_biotype: protein_coding
description:
  Lipoprotein; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.


ensembl_gene_id: VF_1918
symbol: dapA
gene_biotype: protein_coding
description:
  Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).


ensembl_gene_id: VF_1922
symbol: yfgC
gene_biotype: protein_coding
description:
  Predicted peptidase; Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state.


ensembl_gene_id: VF_1927
symbol: upp
gene_biotype: protein_coding
description:
  Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate.


ensembl_gene_id: VF_1929
symbol: purN
gene_biotype: protein_coding
description:
  Phosphoribosylglycinamide formyltransferase 1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.


ensembl_gene_id: VF_1931
symbol: lpcA
gene_biotype: protein_coding
description:
  D-sedoheptulose 7-phosphate isomerase; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.


ensembl_gene_id: VF_1935
symbol: dnaQ
gene_biotype: protein_coding
description:
  DNA polymerase III epsilon subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease.


ensembl_gene_id: VF_1938
symbol: gloB
gene_biotype: protein_coding
description:
  Hydroxyacylglutathione hydrolase; Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl- glutathione to form glutathione and D-lactic acid.


ensembl_gene_id: VF_1945
symbol: tilS
gene_biotype: protein_coding
description:
  tRNA(Ile)-lysidine synthetase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family.


ensembl_gene_id: VF_1946
symbol: accA
gene_biotype: protein_coding
description:
  acetyl-CoA carboxylase, carboxytransferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.


ensembl_gene_id: VF_1948
symbol: rnhB
gene_biotype: protein_coding
description:
  Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.


ensembl_gene_id: VF_1949
symbol: lpxB
gene_biotype: protein_coding
description:
  tetraacyldisaccharide-1-P synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.


ensembl_gene_id: VF_1950
symbol: lpxA
gene_biotype: protein_coding
description:
  UDP-N-acetylglucosamine acetyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.


ensembl_gene_id: VF_1951
symbol: fabZ
gene_biotype: protein_coding
description:
  (3R)-hydroxymyristol acyl carrier protein dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.


ensembl_gene_id: VF_1952
symbol: lpxD
gene_biotype: protein_coding
description:
  UDP-3-O-(3-hydroxymyristoyl)-glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily.


ensembl_gene_id: VF_1953
symbol: skp
gene_biotype: protein_coding
description:
  Periplasmic chaperone; Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm.


ensembl_gene_id: VF_1954
symbol: yaeT
gene_biotype: protein_coding
description:
  Beta barrel component of outer membrane protein assembly complex (YaeT, Omp85); Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.


ensembl_gene_id: VF_1956
symbol: dxr
gene_biotype: protein_coding
description:
  1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family.


ensembl_gene_id: VF_1958
symbol: ispU
gene_biotype: protein_coding
description:
  Undecaprenyl pyrophosphate synthase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di- trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide.


ensembl_gene_id: VF_1959
symbol: frr
gene_biotype: protein_coding
description:
  Ribosome recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family.


ensembl_gene_id: VF_1961
symbol: tsf
gene_biotype: protein_coding
description:
  Protein chain elongation factor EF-Ts; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family.


ensembl_gene_id: VF_1963
symbol: map
gene_biotype: protein_coding
description:
  Methionine aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.


ensembl_gene_id: VF_1964
symbol: glnD
gene_biotype: protein_coding
description:
  Uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.


ensembl_gene_id: VF_1966
symbol: secF
gene_biotype: protein_coding
description:
  SecYEG protein translocase auxillary subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.


ensembl_gene_id: VF_1968
symbol: yajC
gene_biotype: protein_coding
description:
  SecYEG protein translocase auxillary subunit; The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions.


ensembl_gene_id: VF_1969
symbol: tgt
gene_biotype: protein_coding
description:
  tRNA-guanine transglycosylase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the  [...]


ensembl_gene_id: VF_1970
symbol: queA
gene_biotype: protein_coding
description:
  S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).


ensembl_gene_id: VF_1974
symbol: VF_1974
gene_biotype: protein_coding
description:
  Hydrogen peroxide-inducible genes activator, LysR family; Belongs to the LysR transcriptional regulatory family.


ensembl_gene_id: VF_1976
symbol: cutC
gene_biotype: protein_coding
description:
  Copper homeostasis protein; Participates in the control of copper homeostasis. Belongs to the CutC family.


ensembl_gene_id: VF_1982
symbol: phoU
gene_biotype: protein_coding
description:
  Negative regulator of PhoR/PhoB two-component regulator; Plays a role in the regulation of phosphate uptake.


ensembl_gene_id: VF_1983
symbol: pstB
gene_biotype: protein_coding
description:
  Phosphate transporter ATP-binding subunit; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.


ensembl_gene_id: VF_1993
symbol: dnaJ
gene_biotype: protein_coding
description:
  Chaperone Hsp40/DnaJ, co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent intera [...]


ensembl_gene_id: VF_1994
symbol: dnaK
gene_biotype: protein_coding
description:
  Chaperone Hsp70/DnaK, co-chaperone with DnaJ; Acts as a chaperone; Belongs to the heat shock protein 70 family.


ensembl_gene_id: VF_1996
symbol: grpE
gene_biotype: protein_coding
description:
  Heat shock protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depen [...]


ensembl_gene_id: VF_1997
symbol: nadK
gene_biotype: protein_coding
description:
  NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.


ensembl_gene_id: VF_1999
symbol: bamE
gene_biotype: protein_coding
description:
  Small protein A; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.


ensembl_gene_id: VF_2002
symbol: smpB
gene_biotype: protein_coding
description:
  SsrA-binding protein; Required for rescue of stalled ribosomes mediated by trans- translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to [...]


ensembl_gene_id: VF_2046
symbol: malK2
gene_biotype: protein_coding
description:
  Maltose/maltodextrin transport ATP-binding protein MalK2; Belongs to the ABC transporter superfamily.


ensembl_gene_id: VF_2056
symbol: pdxY
gene_biotype: protein_coding
description:
  Pyridoxal kinase 2/pyridoxine kinase; Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP.


ensembl_gene_id: VF_2063
symbol: metA
gene_biotype: protein_coding
description:
  Homoserine transsuccinylase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family.


ensembl_gene_id: VF_2064
symbol: dcuB
gene_biotype: protein_coding
description:
  C4-dicarboxylate antiporter; Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane; Belongs to the DcuA/DcuB transporter (TC 2.A.13.1) family.


ensembl_gene_id: VF_2067
symbol: rpoS
gene_biotype: protein_coding
description:
  RNA polymerase, sigma-S (sigma-38) factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response.


ensembl_gene_id: VF_2069
symbol: pcm
gene_biotype: protein_coding
description:
  L-isoaspartate protein carboxylmethyltransferase type II; Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.


ensembl_gene_id: VF_2070
symbol: surE
gene_biotype: protein_coding
description:
  Broad specificity 5'(3')-nucleotidase and polyphosphatase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.


ensembl_gene_id: VF_2071
symbol: truD
gene_biotype: protein_coding
description:
  Pseudoruidine synthase; Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs; Belongs to the pseudouridine synthase TruD family.


ensembl_gene_id: VF_2072
symbol: ispF
gene_biotype: protein_coding
description:
  2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).


ensembl_gene_id: VF_2073
symbol: ispD
gene_biotype: protein_coding
description:
  4-diphosphocytidyl-2C-methyl-D-erythritol synthase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).


ensembl_gene_id: VF_2074
symbol: ftsB
gene_biotype: protein_coding
description:
  Cell division protein; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.


ensembl_gene_id: VF_2075
symbol: eno
gene_biotype: protein_coding
description:
  Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.


ensembl_gene_id: VF_2076
symbol: pyrG
gene_biotype: protein_coding
description:
  CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.


ensembl_gene_id: VF_2079
symbol: flaF
gene_biotype: protein_coding
description:
  Flagellin FlaF; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.


ensembl_gene_id: VF_2080
symbol: relA
gene_biotype: protein_coding
description:
  (p)ppGpp synthetase I/GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.


ensembl_gene_id: VF_2081
symbol: rumA
gene_biotype: protein_coding
description:
  23S rRNA (uracil-5)-methyltransferase; Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily.


ensembl_gene_id: VF_2083
symbol: acpS
gene_biotype: protein_coding
description:
  Holo-(acyl-carrier-protein) synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family.


ensembl_gene_id: VF_2084
symbol: pdxJ
gene_biotype: protein_coding
description:
  Pyridoxine 5'-phosphate synthase; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.


ensembl_gene_id: VF_2086
symbol: era
gene_biotype: protein_coding
description:
  Membrane-associated, 16S rRNA-binding GTPase; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.


ensembl_gene_id: VF_2087
symbol: rnc
gene_biotype: protein_coding
description:
  RNase III; Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.


ensembl_gene_id: VF_2089
symbol: lepA
gene_biotype: protein_coding
description:
  GTP-binding membrane protein; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner.


ensembl_gene_id: VF_2092
symbol: rseA
gene_biotype: protein_coding
description:
  anti-sigmaE factor, inner membrane; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases [...]


ensembl_gene_id: VF_2094
symbol: nadB
gene_biotype: protein_coding
description:
  Quinolinate synthase, L-aspartate oxidase (B protein) subunit; Catalyzes the oxidation of L-aspartate to iminoaspartate.


ensembl_gene_id: VF_2096
symbol: sdhE
gene_biotype: protein_coding
description:
  Hypothetical protein; An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH and other flavinylated proteins as well.


ensembl_gene_id: VF_2097
symbol: ygfZ
gene_biotype: protein_coding
description:
  Predicted folate-dependent regulatory protein; Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication; Belongs to the tRNA-modifying YgfZ family.


ensembl_gene_id: VF_2103
symbol: VF_2103
gene_biotype: protein_coding
description:
  Hypothetical protein; Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division.


ensembl_gene_id: VF_2105
symbol: rpiA
gene_biotype: protein_coding
description:
  Ribose 5-phosphate isomerase, constitutive; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.


ensembl_gene_id: VF_2106
symbol: serA
gene_biotype: protein_coding
description:
  D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.


ensembl_gene_id: VF_2113
symbol: ung
gene_biotype: protein_coding
description:
  uracil-DNA-glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.


ensembl_gene_id: VF_2115
symbol: yfiD
gene_biotype: protein_coding
description:
  Pyruvate formate lyase subunit; Acts as a radical domain for damaged PFL and possibly other radical proteins.


ensembl_gene_id: VF_2117
symbol: thrB
gene_biotype: protein_coding
description:
  Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.


ensembl_gene_id: VF_2118
symbol: thrA
gene_biotype: protein_coding
description:
  Fused aspartokinase I and homoserine dehydrogenase I; In the C-terminal section; belongs to the homoserine dehydrogenase family.


ensembl_gene_id: VF_2119
symbol: rraA2
gene_biotype: protein_coding
description:
  Ribonuclease E (RNase E) inhibitor protein; Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions.


ensembl_gene_id: VF_2128
symbol: mtn
gene_biotype: protein_coding
description:
  5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.


ensembl_gene_id: VF_2137
symbol: rsmC
gene_biotype: protein_coding
description:
  16S rRNA m2G1207 methylase; Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle; Belongs to the methyltransferase superfamily. RsmC family.


ensembl_gene_id: VF_2158
symbol: acnB
gene_biotype: protein_coding
description:
  Bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Belongs to the aconitase/IPM isomerase family.


ensembl_gene_id: VF_2162
symbol: mrcB
gene_biotype: protein_coding
description:
  Fused glycosyl transferase and transpeptidase; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits).


ensembl_gene_id: VF_2164
symbol: sfsA
gene_biotype: protein_coding
description:
  Sugar fermentation stimulation protein A, predicted DNA-binding transcriptional regulator; Belongs to the SfsA family.


ensembl_gene_id: VF_2165
symbol: dksA
gene_biotype: protein_coding
description:
  DNA-binding transcriptional regulator of rRNA transcription, DnaK suppressor protein; Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression.


ensembl_gene_id: VF_2166
symbol: pcnB
gene_biotype: protein_coding
description:
  poly(A) polymerase I; Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control. Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.


ensembl_gene_id: VF_2169
symbol: panB
gene_biotype: protein_coding
description:
  3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family.


ensembl_gene_id: VF_2170
symbol: panC
gene_biotype: protein_coding
description:
  Pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family.


ensembl_gene_id: VF_2174
symbol: can
gene_biotype: protein_coding
description:
  Carbonic anhydrase; Reversible hydration of carbon dioxide. Belongs to the beta-class carbonic anhydrase family.


ensembl_gene_id: VF_2176
symbol: hpt
gene_biotype: protein_coding
description:
  Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.


ensembl_gene_id: VF_2179
symbol: aceF
gene_biotype: protein_coding
description:
  Pyruvate dehydrogenase, dihydrolipoyltransacetylase component E2; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).


ensembl_gene_id: VF_2181
symbol: aceE
gene_biotype: protein_coding
description:
  Pyruvate dehydrogenase, decarboxylase component E1, thiamin-binding; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).


ensembl_gene_id: VF_2188
symbol: pilD
gene_biotype: protein_coding
description:
  Type 4 prepilin peptidase PilD; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue.


ensembl_gene_id: VF_2189
symbol: coaE
gene_biotype: protein_coding
description:
  dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family.


ensembl_gene_id: VF_2190
symbol: yacF
gene_biotype: protein_coding
description:
  Conserved protein; Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity.


ensembl_gene_id: VF_2191
symbol: yacG
gene_biotype: protein_coding
description:
  Non-essential pilus assembly protein; Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C- terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.


ensembl_gene_id: VF_2192
symbol: mutT
gene_biotype: protein_coding
description:
  Nucleoside triphosphate pyrophosphohydrolase, marked preference for dGTP; Belongs to the Nudix hydrolase family.


ensembl_gene_id: VF_2193
symbol: secA
gene_biotype: protein_coding
description:
  Preprotein translocase subunit, ATPase; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. Belongs to the SecA family.


ensembl_gene_id: VF_2195
symbol: lpxC
gene_biotype: protein_coding
description:
  UDP-3-O-acyl N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family.


ensembl_gene_id: VF_2196
symbol: ftsZ
gene_biotype: protein_coding
description:
  GTP-binding tubulin-like cell division protein; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.


ensembl_gene_id: VF_2197
symbol: ftsA
gene_biotype: protein_coding
description:
  ATP-binding cell division protein involved in recruitment of FtsK to Z ring; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family.


ensembl_gene_id: VF_2199
symbol: ftsQ
gene_biotype: protein_coding
description:
  Cell division protein FtsQ; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly.


ensembl_gene_id: VF_2201
symbol: murG
gene_biotype: protein_coding
description:
  N-acetylglucosaminyltransferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily.


ensembl_gene_id: VF_2202
symbol: ftsW
gene_biotype: protein_coding
description:
  Integral membrane protein involved in stabilizing FtsZ ring during cell division; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily.


ensembl_gene_id: VF_2203
symbol: murD
gene_biotype: protein_coding
description:
  UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family.


ensembl_gene_id: VF_2204
symbol: mraY
gene_biotype: protein_coding
description:
  phospho-N-acetylmuramoyl-pentapeptide transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily.


ensembl_gene_id: VF_2205
symbol: murF
gene_biotype: protein_coding
description:
  UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D- alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily.


ensembl_gene_id: VF_2206
symbol: murE
gene_biotype: protein_coding
description:
  UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:meso- diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily.


ensembl_gene_id: VF_2207
symbol: ftsI
gene_biotype: protein_coding
description:
  Transpeptidase (penicillin-binding protein 3); Catalyzes cross-linking of the peptidoglycan cell wall at the division septum; Belongs to the transpeptidase family. FtsI subfamily.


ensembl_gene_id: VF_2208
symbol: ftsL
gene_biotype: protein_coding
description:
  Membrane bound cell division protein at septum containing leucine zipper motif; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.


ensembl_gene_id: VF_2209
symbol: mraW
gene_biotype: protein_coding
description:
  S-adenosyl-dependent methyltransferase activity on membrane-located substrates; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.


ensembl_gene_id: VF_2210
symbol: yraL
gene_biotype: protein_coding
description:
  Predicted methyltransferase; Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.


ensembl_gene_id: VF_2211
symbol: yraM
gene_biotype: protein_coding
description:
  Conserved protein; Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a).


ensembl_gene_id: VF_2213
symbol: diaA
gene_biotype: protein_coding
description:
  DnaA initiator-associating factor for replication initiation; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.


ensembl_gene_id: VF_2218
symbol: VF_2218
gene_biotype: protein_coding
description:
  Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.


ensembl_gene_id: VF_2220
symbol: VF_2220
gene_biotype: protein_coding
description:
  Ubiquinol-cytochrome c reductase iron-sulfur subunit; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.


ensembl_gene_id: VF_2222
symbol: rplM
gene_biotype: protein_coding
description:
  50S ribosomal subunit protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.


ensembl_gene_id: VF_2223
symbol: yhcM
gene_biotype: protein_coding
description:
  Conserved protein with nucleoside triphosphate hydrolase domain; Reduces the stability of FtsZ polymers in the presence of ATP.


ensembl_gene_id: VF_2227
symbol: parC
gene_biotype: protein_coding
description:
  DNA topoisomerase IV, subunit A; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily.


ensembl_gene_id: VF_2228
symbol: parE
gene_biotype: protein_coding
description:
  DNA topoisomerase IV, subunit B; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 1 subfamily.


ensembl_gene_id: VF_2230
symbol: cpdA
gene_biotype: protein_coding
description:
  Cyclic 3',5'-adenosine monophosphate phosphodiesterase; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.


ensembl_gene_id: VF_2234
symbol: rfaE
gene_biotype: protein_coding
description:
  Fused heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7- phosphate at the C-1 position to selectively form D-glycero-beta-D- manno-heptose-1,7-bisphosphate; In the C-terminal section; belongs to the cytidylyltransferase family.


ensembl_gene_id: VF_2235
symbol: glnE
gene_biotype: protein_coding
description:
  Fused deadenylyltransferase/adenylyltransferase for glutamine synthetase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of  [...]


ensembl_gene_id: VF_2244
symbol: cca
gene_biotype: protein_coding
description:
  Fused tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase and phosphatase; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'-nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases.


ensembl_gene_id: VF_2245
symbol: bacA
gene_biotype: protein_coding
description:
  Undecaprenyl pyrophosphate phosphatase; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family.


ensembl_gene_id: VF_2247
symbol: folB
gene_biotype: protein_coding
description:
  Bifunctional dihydroneopterin aldolase/dihydroneopterin triphosphate 2'-epimerase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin.


ensembl_gene_id: VF_2248
symbol: ygiH
gene_biotype: protein_coding
description:
  Conserved inner membrane protein; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.


ensembl_gene_id: VF_2249
symbol: ygjD
gene_biotype: protein_coding
description:
  Predicted peptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family.


ensembl_gene_id: VF_2252
symbol: dnaG
gene_biotype: protein_coding
description:
  DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.


ensembl_gene_id: VF_2254
symbol: rpoD
gene_biotype: protein_coding
description:
  RNA polymerase, sigma-70 (sigma-D) factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.


ensembl_gene_id: VF_2266
symbol: metL
gene_biotype: protein_coding
description:
  Fused aspartokinase II/homoserine dehydrogenase II; In the C-terminal section; belongs to the homoserine dehydrogenase family.


ensembl_gene_id: VF_2268
symbol: metJ
gene_biotype: protein_coding
description:
  DNA-binding transcriptional repressor, S-adenosylmethionine-binding; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis.


ensembl_gene_id: VF_2274
symbol: priA
gene_biotype: protein_coding
description:
  Primosome factor n' (replication factor Y); Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily.


ensembl_gene_id: VF_2277
symbol: hslV
gene_biotype: protein_coding
description:
  Peptidase component of the HslUV protease; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.


ensembl_gene_id: VF_2278
symbol: hslU
gene_biotype: protein_coding
description:
  Molecular chaperone and ATPase component of HslUV protease; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.


ensembl_gene_id: VF_2282
symbol: astD
gene_biotype: protein_coding
description:
  Succinylglutamic semialdehyde dehydrogenase; Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate.


ensembl_gene_id: VF_2284
symbol: argD
gene_biotype: protein_coding
description:
  Bifunctional acetylornithine aminotransferase/ succinyldiaminopimelate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.


ensembl_gene_id: VF_2286
symbol: trpS
gene_biotype: protein_coding
description:
  tryptophanyl-tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family.


ensembl_gene_id: VF_2287
symbol: gph
gene_biotype: protein_coding
description:
  Phosphoglycolate phosphatase; Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.


ensembl_gene_id: VF_2291
symbol: aroB
gene_biotype: protein_coding
description:
  3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.


ensembl_gene_id: VF_2292
symbol: aroK
gene_biotype: protein_coding
description:
  Shikimate kinase I; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family.


ensembl_gene_id: VF_2299
symbol: oxyR
gene_biotype: protein_coding
description:
  Oxidative stress-responsive DNA-binding transcriptional regulator OxyR; Belongs to the LysR transcriptional regulatory family.


ensembl_gene_id: VF_2305
symbol: argB
gene_biotype: protein_coding
description:
  Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily.


ensembl_gene_id: VF_2306
symbol: argC
gene_biotype: protein_coding
description:
  N-acetyl-gamma-glutamylphosphate reductase, NAD(P)-binding; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.


ensembl_gene_id: VF_2308
symbol: ppc
gene_biotype: protein_coding
description:
  Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.


ensembl_gene_id: VF_2309
symbol: metF
gene_biotype: protein_coding
description:
  5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.


ensembl_gene_id: VF_2311
symbol: rpsR
gene_biotype: protein_coding
description:
  30S ribosomal subunit protein S18; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family.


ensembl_gene_id: VF_2313
symbol: rlmB
gene_biotype: protein_coding
description:
  23S rRNA (Gm2251)-methyltransferase; Specifically methylates the ribose of guanosine 2251 in 23S rRNA.


ensembl_gene_id: VF_2314
symbol: rnr
gene_biotype: protein_coding
description:
  Exoribonuclease R, RNase R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.


ensembl_gene_id: VF_2315
symbol: nsrR
gene_biotype: protein_coding
description:
  Nitrite-responsive HTH-type transcriptional repressor NsrR; Nitric oxide-sensitive repressor of genes involved in protecting the cell against nitrosative stress. May require iron for activity.


ensembl_gene_id: VF_2316
symbol: hmp
gene_biotype: protein_coding
description:
  Fused nitric oxide dioxygenase/dihydropteridine reductase 2; Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress; Belongs to the globin family. Two-domain flavohemoproteins subfamily.


ensembl_gene_id: VF_2320
symbol: hflC
gene_biotype: protein_coding
description:
  Modulator for HflB protease specific for phage lambda cII repressor; HflC and HflK could regulate a protease.


ensembl_gene_id: VF_2321
symbol: hflK
gene_biotype: protein_coding
description:
  Modulator for HflB protease specific for phage lambda cII repressor; HflC and HflK could encode or regulate a protease.


ensembl_gene_id: VF_2322
symbol: hflX
gene_biotype: protein_coding
description:
  Predicted GTPase; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.


ensembl_gene_id: VF_2323
symbol: hfq
gene_biotype: protein_coding
description:
  RNA chaperone Hfq (HF-I); RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family.


ensembl_gene_id: VF_2324
symbol: miaA
gene_biotype: protein_coding
description:
  Delta(2)-isopentenylpyrophosphate tRNA-adenosine transferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family.


ensembl_gene_id: VF_2325
symbol: mutL
gene_biotype: protein_coding
description:
  Methyl-directed mismatch repair protein; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.


ensembl_gene_id: VF_2328
symbol: yjeS
gene_biotype: protein_coding
description:
  Predicted Fe-S electron transport protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr); Belongs to the QueG family.


ensembl_gene_id: VF_2329
symbol: orn
gene_biotype: protein_coding
description:
  Oligoribonuclease; 3'-to-5' exoribonuclease specific for small oligoribonucleotides; Belongs to the oligoribonuclease family.


ensembl_gene_id: VF_2330
symbol: rsgA
gene_biotype: protein_coding
description:
  Ribosome small subunit-dependent GTPase A; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.


ensembl_gene_id: VF_2331
symbol: psd
gene_biotype: protein_coding
description:
  Phosphatidylserine decarboxylase; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).


ensembl_gene_id: VF_2333
symbol: poxA
gene_biotype: protein_coding
description:
  Predicted lysyl-tRNA synthetase; With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF- P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta-lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P; Belongs to the class-II aminoacyl-tRNA synthetase family. EpmA subfamily.


ensembl_gene_id: VF_2335
symbol: frdB
gene_biotype: protein_coding
description:
  Fumarate reductase (anaerobic), Fe-S subunit; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.


ensembl_gene_id: VF_2336
symbol: frdC
gene_biotype: protein_coding
description:
  Fumarate reductase (anaerobic), membrane anchor subunit; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane.


ensembl_gene_id: VF_2338
symbol: efp
gene_biotype: protein_coding
description:
  Elongation factor EF-P; Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation; Belongs to the elongation factor P family.


ensembl_gene_id: VF_2340
symbol: pfkA
gene_biotype: protein_coding
description:
  6-phosphofructokinase I; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.


ensembl_gene_id: VF_2345
symbol: yibK
gene_biotype: protein_coding
description:
  Predicted rRNA methylase; Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide.


ensembl_gene_id: VF_2348
symbol: gpsA
gene_biotype: protein_coding
description:
  Glycerol-3-phosphate dehydrogenase (NAD+); Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.


ensembl_gene_id: VF_2349
symbol: secB
gene_biotype: protein_coding
description:
  Protein export chaperone; One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA.


ensembl_gene_id: VF_2356
symbol: dipZ
gene_biotype: protein_coding
description:
  Fused thiol:disulfide interchange protein: activator of DsbC/conserved protein; Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps. Belongs to the thioredoxin family. DsbD subfamily.


ensembl_gene_id: VF_2357
symbol: nagB
gene_biotype: protein_coding
description:
  Glucosamine-6-phosphate deaminase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.


ensembl_gene_id: VF_2360
symbol: gapA2
gene_biotype: protein_coding
description:
  Glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.


ensembl_gene_id: VF_2367
symbol: znuC2
gene_biotype: protein_coding
description:
  High-affinity zinc uptake system ATP-binding protein ZnuC2; Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Zinc importer (TC 3.A.1.15.5) family.


ensembl_gene_id: VF_2372
symbol: glmS
gene_biotype: protein_coding
description:
  L-glutamine:D-fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.


ensembl_gene_id: VF_2383
symbol: acs
gene_biotype: protein_coding
description:
  acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.


ensembl_gene_id: VF_2385
symbol: aroQ
gene_biotype: protein_coding
description:
  3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family.


ensembl_gene_id: VF_2386
symbol: accB
gene_biotype: protein_coding
description:
  Acetyl CoA carboxylase, BCCP subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.


ensembl_gene_id: VF_2387
symbol: accC
gene_biotype: protein_coding
description:
  acetyl-CoA carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.


ensembl_gene_id: VF_2388
symbol: prmA
gene_biotype: protein_coding
description:
  Methylase for 50S ribosomal subunit protein L11; Methylates ribosomal protein L11; Belongs to the methyltransferase superfamily. PrmA family.


ensembl_gene_id: VF_2389
symbol: dusB
gene_biotype: protein_coding
description:
  tRNA-dihydrouridine synthase B; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the Dus family. DusB subfamily.


ensembl_gene_id: VF_2391
symbol: fis
gene_biotype: protein_coding
description:
  Global DNA-binding transcriptional dual regulator Fis; Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters; Belongs to the transcriptional regulatory Fis family.


ensembl_gene_id: VF_2395
symbol: purD
gene_biotype: protein_coding
description:
  Phosphoribosylglycinamide synthetase phosphoribosylamine-glycine ligase; Belongs to the GARS family.


ensembl_gene_id: VF_2397
symbol: hupA
gene_biotype: protein_coding
description:
  HU, DNA-binding transcriptional regulator, alpha subunit; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.


ensembl_gene_id: VF_2402
symbol: hemE
gene_biotype: protein_coding
description:
  Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.


ensembl_gene_id: VF_2412
symbol: rpoC
gene_biotype: protein_coding
description:
  RNA polymerase, beta prime subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.


ensembl_gene_id: VF_2414
symbol: rpoB
gene_biotype: protein_coding
description:
  RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.


ensembl_gene_id: VF_2415
symbol: rplL
gene_biotype: protein_coding
description:
  50S ribosomal subunit protein L7/L12; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family.


ensembl_gene_id: VF_2418
symbol: rplA
gene_biotype: protein_coding
description:
  50S ribosomal subunit protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.


ensembl_gene_id: VF_2419
symbol: rplK
gene_biotype: protein_coding
description:
  50S ribosomal subunit protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.


ensembl_gene_id: VF_2421
symbol: nusG
gene_biotype: protein_coding
description:
  Transcription termination factor NusG; Participates in transcription elongation, termination and antitermination.


ensembl_gene_id: VF_2422
symbol: secE
gene_biotype: protein_coding
description:
  Preprotein translocase membrane subunit; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation; Belongs to the SecE/SEC61-gamma family.


ensembl_gene_id: VF_2425
symbol: birA
gene_biotype: protein_coding
description:
  BirA transcriptional repressor, biotin-(acetyl-CoA-carboxylase) ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon.


ensembl_gene_id: VF_2435
symbol: btuB
gene_biotype: protein_coding
description:
  Vitamin B12/cobalamin outer membrane transporter; Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans- periplasmic membrane protein TonB; Belongs to the TonB-dependent receptor family. BtuB (TC 1.B.14.3.1) subfamily.


ensembl_gene_id: VF_2436
symbol: trmA
gene_biotype: protein_coding
description:
  tRNA (uracil-5-)-methyltransferase; Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA).


ensembl_gene_id: VF_2439
symbol: sthA
gene_biotype: protein_coding
description:
  Pyridine nucleotide transhydrogenase, soluble; Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.


ensembl_gene_id: VF_2442
symbol: lexA
gene_biotype: protein_coding
description:
  DNA-binding transcriptional repressor of SOS regulon; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.


ensembl_gene_id: VF_2444
symbol: ubiA
gene_biotype: protein_coding
description:
  P-hydroxybenzoate octaprenyltransferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.


ensembl_gene_id: VF_2445
symbol: ubiC
gene_biotype: protein_coding
description:
  Chorismate--pyruvate lyase; Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway; Belongs to the UbiC family.


ensembl_gene_id: VF_2446
symbol: fliL2
gene_biotype: protein_coding
description:
  Flagellar basal body-associated protein FliL2; Controls the rotational direction of flagella during chemotaxis; Belongs to the FliL family.


ensembl_gene_id: VF_2448
symbol: glpE
gene_biotype: protein_coding
description:
  Thiosulfate:cyanide sulfurtransferase (rhodanese); Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide.


ensembl_gene_id: VF_2450
symbol: rpoH
gene_biotype: protein_coding
description:
  RNA polymerase, sigma-32 (sigma-H) factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes.


ensembl_gene_id: VF_2451
symbol: ftsX
gene_biotype: protein_coding
description:
  Predicted transporter subunit: membrane component of ABC superfamily; Part of the ABC transporter FtsEX involved in cellular division; Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.


ensembl_gene_id: VF_2452
symbol: ftsE
gene_biotype: protein_coding
description:
  Predicted transporter subunit: ATP-binding component of ABC superfamily; Part of the ABC transporter FtsEX involved in cellular division.


ensembl_gene_id: VF_2453
symbol: ftsY
gene_biotype: protein_coding
description:
  Fused Signal Recognition Particle (SRP) receptor: membrane binding protein/conserved protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.


ensembl_gene_id: VF_2454
symbol: rsmD
gene_biotype: protein_coding
description:
  Predicted methyltransferase; Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle; Belongs to the methyltransferase superfamily. RsmD family.


ensembl_gene_id: VF_2460
symbol: recG
gene_biotype: protein_coding
description:
  ATP-dependent DNA helicase; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily.


ensembl_gene_id: VF_2461
symbol: gntY
gene_biotype: protein_coding
description:
  Predicted gluconate transport associated protein; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins.


ensembl_gene_id: VF_2462
symbol: cysQ
gene_biotype: protein_coding
description:
  PAPS (adenosine 3'-phosphate 5'-phosphosulfate) 3'(2'),5'-bisphosphate nucleotidase; Converts adenosine-3',5'-bisphosphate (PAP) to AMP. Belongs to the inositol monophosphatase superfamily. CysQ family.


ensembl_gene_id: VF_2465
symbol: gspM
gene_biotype: protein_coding
description:
  Cholera toxin secretion protein EpsM; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins.


ensembl_gene_id: VF_2466
symbol: gspL
gene_biotype: protein_coding
description:
  General secretion pathway protein L; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins.


ensembl_gene_id: VF_2473
symbol: gspE
gene_biotype: protein_coding
description:
  General secretion pathway protein E; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins.


ensembl_gene_id: VF_2477
symbol: hslO
gene_biotype: protein_coding
description:
  Heat shock and oxidative stress chaperone Hsp33; Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.


ensembl_gene_id: VF_2478
symbol: pck
gene_biotype: protein_coding
description:
  Phosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.


ensembl_gene_id: VF_2484
symbol: dapF
gene_biotype: protein_coding
description:
  Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan.


ensembl_gene_id: VF_2485
symbol: lysA
gene_biotype: protein_coding
description:
  Diaminopimelate decarboxylase, PLP-binding; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine.


ensembl_gene_id: VF_2486
symbol: cyaY
gene_biotype: protein_coding
description:
  Frataxin, iron-binding and oxidizing protein; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis.


ensembl_gene_id: VF_2488
symbol: yhiR
gene_biotype: protein_coding
description:
  Predicted DNA (exogenous) processing protein; Specifically methylates the adenine in position 2030 of 23S rRNA.


ensembl_gene_id: VF_2521
symbol: rep
gene_biotype: protein_coding
description:
  DNA helicase and single-stranded DNA-dependent ATPase; Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replication; it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction.


ensembl_gene_id: VF_2528
symbol: ilvC
gene_biotype: protein_coding
description:
  Ketol-acid reductoisomerase, NAD(P)-binding; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.


ensembl_gene_id: VF_2535
symbol: aroE
gene_biotype: protein_coding
description:
  Dehydroshikimate reductase, NAD(P)-binding; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).


ensembl_gene_id: VF_2536
symbol: rimN
gene_biotype: protein_coding
description:
  Predicted ribosome maturation factor; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate.


ensembl_gene_id: VF_2537
symbol: purE
gene_biotype: protein_coding
description:
  N5-carboxyaminoimidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).


ensembl_gene_id: VF_2538
symbol: purK
gene_biotype: protein_coding
description:
  N5-carboxyaminoimidazole ribonucleotide synthase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR); Belongs to the PurK/PurT family.


ensembl_gene_id: VF_2543
symbol: def
gene_biotype: protein_coding
description:
  Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.


ensembl_gene_id: VF_2544
symbol: fmt
gene_biotype: protein_coding
description:
  10-formyltetrahydrofolate:L-methionyl-tRNA(fMet) N-formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family.


ensembl_gene_id: VF_2545
symbol: rsmB
gene_biotype: protein_coding
description:
  16S rRNA m5C967 methyltransferase, S-adenosyl-L-methionine-dependent; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.


ensembl_gene_id: VF_2547
symbol: trkH2
gene_biotype: protein_coding
description:
  Trk system potassium uptake protein TrkH; Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA; Belongs to the TrkH potassium transport family.


ensembl_gene_id: VF_2552
symbol: rdoA
gene_biotype: protein_coding
description:
  Thr/Ser kinase implicated in Cpx signal transduction; A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response.


ensembl_gene_id: VF_2558
symbol: ilvE
gene_biotype: protein_coding
description:
  Branched-chain amino-acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.


ensembl_gene_id: VF_2560
symbol: ilvA
gene_biotype: protein_coding
description:
  Threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.


ensembl_gene_id: VF_2562
symbol: glmU
gene_biotype: protein_coding
description:
  Fused N-acetyl glucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyl transferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belo [...]


ensembl_gene_id: VF_2563
symbol: atpC
gene_biotype: protein_coding
description:
  ATP synthase F1, epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane.


ensembl_gene_id: VF_2564
symbol: atpD
gene_biotype: protein_coding
description:
  ATP synthase F1, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family.


ensembl_gene_id: VF_2565
symbol: atpG
gene_biotype: protein_coding
description:
  ATP synthase F1, gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.


ensembl_gene_id: VF_2566
symbol: atpA
gene_biotype: protein_coding
description:
  ATP synthase F1, alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family.


ensembl_gene_id: VF_2567
symbol: atpH
gene_biotype: protein_coding
description:
  ATP synthase F1, delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family.


ensembl_gene_id: VF_2568
symbol: atpF
gene_biotype: protein_coding
description:
  ATP synthase F0, B subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.


ensembl_gene_id: VF_2569
symbol: atpE
gene_biotype: protein_coding
description:
  ATP synthase F0, C subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.


ensembl_gene_id: VF_2570
symbol: atpB
gene_biotype: protein_coding
description:
  ATP synthase F0, A subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.


ensembl_gene_id: VF_2574
symbol: gidB
gene_biotype: protein_coding
description:
  Methyltransferase, SAM-dependent methyltransferase, glucose-inhibited cell-division protein; Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.


ensembl_gene_id: VF_2575
symbol: mnmG
gene_biotype: protein_coding
description:
  Glucose-inhibited cell-division protein; NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34; Belongs to the MnmG family.


ensembl_gene_id: VF_2589
symbol: trmB
gene_biotype: protein_coding
description:
  tRNA (guanine-N(7))-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.


ensembl_gene_id: VF_2592
symbol: oadC
gene_biotype: protein_coding
description:
  Oxaloacetate decarboxylase, gamma subunit; Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation.


ensembl_gene_id: VF_2653
symbol: yadB
gene_biotype: protein_coding
description:
  glutamyl-Q tRNA(Asp) synthetase; Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2- cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon; Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily.


ensembl_gene_id: VF_A0007
symbol: gfa
gene_biotype: protein_coding
description:
  Glutathione-dependent formaldehyde-activating enzyme; Catalyzes the condensation of formaldehyde and glutathione to S-hydroxymethylglutathione; Belongs to the Gfa family.


ensembl_gene_id: VF_A0009
symbol: katA
gene_biotype: protein_coding
description:
  Hydroperoxidase HPII(III) (catalase) KatA; Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide. Could protect cells in nodules which have a high potential to produce hydrogen peroxide because of the strong reducing conditions required for nitrogen fixation and the action of several proteins; Belongs to the catalase family.


ensembl_gene_id: VF_A0018
symbol: rsgA-2
gene_biotype: protein_coding
description:
  Ribosome-associated GTPase; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.


ensembl_gene_id: VF_A0052
symbol: ydfG
gene_biotype: protein_coding
description:
  L-allo-threonine dehydrogenase, NAD(P)-binding; Belongs to the short-chain dehydrogenases/reductases (SDR) family.


ensembl_gene_id: VF_A0062
symbol: yggP
gene_biotype: protein_coding
description:
  Predicted dehydrogenase; Seems to be involved in mannitol utilization. Complements an E. coli mtlD deletion mutant.


ensembl_gene_id: VF_A0082
symbol: dmsA
gene_biotype: protein_coding
description:
  Dimethyl sulfoxide reductase, anaerobic, subunit A; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.


ensembl_gene_id: VF_A0094
symbol: ynjF
gene_biotype: protein_coding
description:
  Predicted phosphatidyl transferase, inner membrane protein; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.


ensembl_gene_id: VF_A0142
symbol: VF_A0142
gene_biotype: protein_coding
description:
  Formate acetyltransferase; Putative transporter, NadC family protein, -1 frameshift to create pseudogene.


ensembl_gene_id: VF_A0143
symbol: gbpA
gene_biotype: protein_coding
description:
  GlcNac-binding protein A; Probably interacts with GlcNAc residues. May promote attachment to both epithelial cell surfaces and chitin. Belongs to the GbpA family.


ensembl_gene_id: VF_A0151
symbol: rhlE
gene_biotype: protein_coding
description:
  RNA helicase; DEAD-box RNA helicase involved in ribosome assembly. Has RNA- dependent ATPase activity and unwinds double-stranded RNA.


ensembl_gene_id: VF_A0160
symbol: fhuB
gene_biotype: protein_coding
description:
  Fused iron-hydroxamate transporter subunits of ABC superfamily: membrane components; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.


ensembl_gene_id: VF_A0177
symbol: ogt
gene_biotype: protein_coding
description:
  O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.


ensembl_gene_id: VF_A0178
symbol: cusS
gene_biotype: protein_coding
description:
  Sensory histidine kinase in two-component regulatory system with CusR, senses copper ions; Member of a two-component regulatory system.


ensembl_gene_id: VF_A0196
symbol: VF_A0196
gene_biotype: protein_coding
description:
  TonB protein; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Belongs to the TonB family.


ensembl_gene_id: VF_A0199
symbol: VF_A0199
gene_biotype: protein_coding
description:
  Chitooligosaccharide transport ATP-binding protein oppD; Belongs to the ABC transporter superfamily.


ensembl_gene_id: VF_A0200
symbol: VF_A0200
gene_biotype: protein_coding
description:
  Chitooligosaccharide transport ATP-binding protein oppF; Belongs to the ABC transporter superfamily.


ensembl_gene_id: VF_A0228
symbol: tadF2
gene_biotype: protein_coding
description:
  ATP/GTP-binding site motif A (P-loop) surface protein, TadF-like protein; Involved in fimbraea and/or secretion.


ensembl_gene_id: VF_A0236
symbol: glpK
gene_biotype: protein_coding
description:
  Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family.


ensembl_gene_id: VF_A0239
symbol: glpD
gene_biotype: protein_coding
description:
  Aerobic glycerol-3-phosphate dehydrogenase GlpD; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.


ensembl_gene_id: VF_A0249
symbol: glpB
gene_biotype: protein_coding
description:
  Sn-glycerol-3-phosphate dehydrogenase (anaerobic), membrane anchor subunit GlpB; Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor.


ensembl_gene_id: VF_A0253
symbol: pepT
gene_biotype: protein_coding
description:
  Peptidase T, PepT; Cleaves the N-terminal amino acid of tripeptides. Belongs to the peptidase M20B family.


ensembl_gene_id: VF_A0272
symbol: VF_A0272
gene_biotype: protein_coding
description:
  Integral membrane protein; Transcriptional regulator, LysR family, amber nonsense codon to create pseudogene.


ensembl_gene_id: VF_A0282
symbol: nrdG
gene_biotype: protein_coding
description:
  Anaerobic ribonucleotide reductase activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.


ensembl_gene_id: VF_A0289
symbol: cobQ
gene_biotype: protein_coding
description:
  Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily.


ensembl_gene_id: VF_A0291
symbol: modB
gene_biotype: protein_coding
description:
  Molybdate ABC transporter, permease protein; Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.


ensembl_gene_id: VF_A0292
symbol: modC
gene_biotype: protein_coding
description:
  Molybdate ABC transporter, ATP-binding protein; Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Molybdate importer (TC 3.A.1.8) family.


ensembl_gene_id: VF_A0320
symbol: VF_A0320
gene_biotype: protein_coding
description:
  Transcriptional activator TenA; Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway; Belongs to the TenA family.


ensembl_gene_id: VF_A0321
symbol: thiM
gene_biotype: protein_coding
description:
  Hydoxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family.


ensembl_gene_id: VF_A0322
symbol: thiE-2
gene_biotype: protein_coding
description:
  Thiamine phosphate synthase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.


ensembl_gene_id: VF_A0355
symbol: galK
gene_biotype: protein_coding
description:
  Galactokinase; Catalyzes the transfer of the gamma-phosphate of ATP to D- galactose to form alpha-D-galactose-1-phosphate (Gal-1-P). Belongs to the GHMP kinase family. GalK subfamily.


ensembl_gene_id: VF_A0383
symbol: rnb
gene_biotype: protein_coding
description:
  Ribonuclease II; Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction.


ensembl_gene_id: VF_A0384
symbol: deaD
gene_biotype: protein_coding
description:
  ATP-dependent RNA helicase; DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation.


ensembl_gene_id: VF_A0394
symbol: aroG
gene_biotype: protein_coding
description:
  3-deoxy-D-arabino-heptulosonate-7-phosphate synthase, phenylalanine repressible; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP).


ensembl_gene_id: VF_A0417
symbol: tdh
gene_biotype: protein_coding
description:
  Threonine 3-dehydrogenase, NAD(P)-binding; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family.


ensembl_gene_id: VF_A0418
symbol: kbl
gene_biotype: protein_coding
description:
  Glycine C-acetyltransferase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.


ensembl_gene_id: VF_A0424
symbol: msbA
gene_biotype: protein_coding
description:
  Fused lipid transporter subunits of ABC superfamily: membrane component/ATP-binding component; Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.


ensembl_gene_id: VF_A0425
symbol: lpxK
gene_biotype: protein_coding
description:
  Lipid A 4'kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).


ensembl_gene_id: VF_A0427
symbol: kdsB
gene_biotype: protein_coding
description:
  3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.


ensembl_gene_id: VF_A0429
symbol: smtA
gene_biotype: protein_coding
description:
  Predicted S-adenosyl-L-methionine-dependent methyltransferase; Catalyzes the methylation of 5-carboxymethoxyuridine (cmo5U) to form 5-methoxycarbonylmethoxyuridine (mcmo5U) at position 34 in tRNAs; Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoM family.


ensembl_gene_id: VF_A0430
symbol: mukF
gene_biotype: protein_coding
description:
  Calcium-binding protein involved in chromosome partioning; Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity.


ensembl_gene_id: VF_A0431
symbol: mukE
gene_biotype: protein_coding
description:
  Protein involved in chromosome partitioning; Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF.


ensembl_gene_id: VF_A0432
symbol: mukB
gene_biotype: protein_coding
description:
  Fused chromosome partitioning protein: predicted nucleotide hydrolase; Belongs to the SMC family. MukB subfamily.


ensembl_gene_id: VF_A0444
symbol: cusB
gene_biotype: protein_coding
description:
  Copper/silver efflux system, membrane fusion protein; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.


ensembl_gene_id: VF_A0445
symbol: cusA
gene_biotype: protein_coding
description:
  Copper/silver efflux system, membrane component; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.


ensembl_gene_id: VF_A0452
symbol: hutG
gene_biotype: protein_coding
description:
  Formimidoylglutamase; Catalyzes the conversion of N-formimidoyl-L-glutamate to L- glutamate and formamide; Belongs to the arginase family.


ensembl_gene_id: VF_A0460
symbol: mfd
gene_biotype: protein_coding
description:
  Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily.


ensembl_gene_id: VF_A0463
symbol: lolD
gene_biotype: protein_coding
description:
  Outer membrane-specific lipoprotein transporter subunit; Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.


ensembl_gene_id: VF_A0468
symbol: zwf
gene_biotype: protein_coding
description:
  Glucose-6-phosphate dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone.


ensembl_gene_id: VF_A0470
symbol: gnd
gene_biotype: protein_coding
description:
  Gluconate-6-phosphate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.


ensembl_gene_id: VF_A0482
symbol: gltS-2
gene_biotype: protein_coding
description:
  Sodium/glutamate symporter; Catalyzes the sodium-dependent transport of glutamate. Belongs to the glutamate:Na(+) symporter (ESS) (TC 2.A.27) family.


ensembl_gene_id: VF_A0483
symbol: mrdB-2
gene_biotype: protein_coding
description:
  Rod shape-determining protein RodA; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily.


ensembl_gene_id: VF_A0492
symbol: anmK
gene_biotype: protein_coding
description:
  anhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family.


ensembl_gene_id: VF_A0493
symbol: nagZ
gene_biotype: protein_coding
description:
  Beta N-acetyl-glucosaminidase; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.


ensembl_gene_id: VF_A0495
symbol: ygcF
gene_biotype: protein_coding
description:
  Conserved protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.


ensembl_gene_id: VF_A0507
symbol: gltS
gene_biotype: protein_coding
description:
  Glutamate transporter; Catalyzes the sodium-dependent transport of glutamate. Belongs to the glutamate:Na(+) symporter (ESS) (TC 2.A.27) family.


ensembl_gene_id: VF_A0511
symbol: RbgA
gene_biotype: protein_coding
description:
  GTP-binding protein; Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity; Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.


ensembl_gene_id: VF_A0539
symbol: VF_A0539
gene_biotype: protein_coding
description:
  Type I restriction-modification system restriction subunit; Subunit R is required for both nuclease and ATPase activities, but not for modification.


ensembl_gene_id: VF_A0554
symbol: ppnP
gene_biotype: protein_coding
description:
  Hypothetical cytosolic protein; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions.


ensembl_gene_id: VF_A0585
symbol: pntB
gene_biotype: protein_coding
description:
  Pyridine nucleotide transhydrogenase, beta subunit; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family.


ensembl_gene_id: VF_A0586
symbol: pntA
gene_biotype: protein_coding
description:
  Pyridine nucleotide transhydrogenase, alpha subunit; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the AlaDH/PNT family.


ensembl_gene_id: VF_A0602
symbol: nadE
gene_biotype: protein_coding
description:
  NAD synthetase, NH3/glutamine-dependent; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.


ensembl_gene_id: VF_A0650
symbol: VF_A0650
gene_biotype: protein_coding
description:
  Antitoxin of toxin-antitoxin (TA) stability system; Antitoxin component of a type II toxin-antitoxin (TA) system.


ensembl_gene_id: VF_A0685
symbol: talB
gene_biotype: protein_coding
description:
  Transaldolase B; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.


ensembl_gene_id: VF_A0686
symbol: tktB
gene_biotype: protein_coding
description:
  Transketolase 2; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.


ensembl_gene_id: VF_A0687
symbol: htrB1
gene_biotype: protein_coding
description:
  Lipid A biosynthesis lauroyl acyltransferase; Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(lauroyl)-lipid IV(A).


ensembl_gene_id: VF_A0695
symbol: guaC
gene_biotype: protein_coding
description:
  GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.


ensembl_gene_id: VF_A0700
symbol: gcvT
gene_biotype: protein_coding
description:
  Aminomethyltransferase, tetrahydrofolate-dependent, subunit (T protein) of glycine cleavage complex.


ensembl_gene_id: VF_A0702
symbol: gcvH
gene_biotype: protein_coding
description:
  Glycine cleavage complex lipoylprotein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.


ensembl_gene_id: VF_A0703
symbol: gcvP
gene_biotype: protein_coding
description:
  Glycine decarboxylase, PLP-dependent, subunit (protein P) of glycine cleavage complex; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.


ensembl_gene_id: VF_A0741
symbol: VF_A0741
gene_biotype: protein_coding
description:
  Glycosyl transferase family, helical bundle domain. This family includes anthranilate phosphoribosyltransferase (TrpD).


ensembl_gene_id: VF_A0745
symbol: bioD
gene_biotype: protein_coding
description:
  Dethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring.


ensembl_gene_id: VF_A0746
symbol: bioC
gene_biotype: protein_coding
description:
  Biotin biosynthesis protein BioC; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway.


ensembl_gene_id: VF_A0747
symbol: bioF
gene_biotype: protein_coding
description:
  8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.


ensembl_gene_id: VF_A0748
symbol: bioA
gene_biotype: protein_coding
description:
  7,8-diaminopelargonic acid synthase, PLP-dependent; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.


ensembl_gene_id: VF_A0781
symbol: VF_A0781
gene_biotype: protein_coding
description:
  Ferrichrome transport system permease protein FhuB; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.


ensembl_gene_id: VF_A0794
symbol: ackA2
gene_biotype: protein_coding
description:
  Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family.


ensembl_gene_id: VF_A0799
symbol: malE
gene_biotype: protein_coding
description:
  Periplasmic maltose-binding protein; Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Binds maltose and higher maltodextrins. Belongs to the bacterial solute-binding protein 1 family.


ensembl_gene_id: VF_A0800
symbol: malK
gene_biotype: protein_coding
description:
  Fused maltose transport subunit, ATP-binding component of ABC superfamily/regulatory protein; Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Maltooligosaccharide importer (TC 3.A.1.1.1) family.


ensembl_gene_id: VF_A0803
symbol: sstT
gene_biotype: protein_coding
description:
  Sodium:serine/threonine symporter; Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system). Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.


ensembl_gene_id: VF_A0806
symbol: glgC
gene_biotype: protein_coding
description:
  Glucose-1-phosphate adenylyltransferase; Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc; Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.


ensembl_gene_id: VF_A0808
symbol: glgB
gene_biotype: protein_coding
description:
  1,4-alpha-glucan branching enzyme; Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position; Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.


ensembl_gene_id: VF_A0810
symbol: malP
gene_biotype: protein_coding
description:
  Maltodextrin phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.


ensembl_gene_id: VF_A0811
symbol: malT
gene_biotype: protein_coding
description:
  Fused conserved protein: DNA-binding transcriptional activator/maltotriose-ATP-binding protein; Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto- oligosaccharides. Specifically binds to the promoter region of its target genes, recognizing a short DNA motif called the MalT box.


ensembl_gene_id: VF_A0825
symbol: VF_A0825
gene_biotype: protein_coding
description:
  Ferric anguibactin transport system permease protein FatC; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.


ensembl_gene_id: VF_A0826
symbol: vctD
gene_biotype: protein_coding
description:
  Ferric anguibactin transport system permease protein FatD; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.


ensembl_gene_id: VF_A0829
symbol: putP
gene_biotype: protein_coding
description:
  Proline:sodium symporter; Catalyzes the sodium-dependent uptake of extracellular L- proline; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.


ensembl_gene_id: VF_A0832
symbol: putA
gene_biotype: protein_coding
description:
  Proline dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family.


ensembl_gene_id: VF_A0840
symbol: speA
gene_biotype: protein_coding
description:
  Biosynthetic arginine decarboxylase, PLP-binding; Catalyzes the biosynthesis of agmatine from arginine.


ensembl_gene_id: VF_A0842
symbol: blc
gene_biotype: protein_coding
description:
  Outer membrane lipoprotein (lipocalin); Involved in the storage or transport of lipids necessary for membrane maintenance under stressful conditions. Displays a binding preference for lysophospholipids.


ensembl_gene_id: VF_A0847
symbol: astB
gene_biotype: protein_coding
description:
  Succinylarginine dihydrolase; Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)- succinylornithine, ammonia and CO(2).


ensembl_gene_id: VF_A0883
symbol: bcsB
gene_biotype: protein_coding
description:
  Regulator of cellulose synthase, cyclic di-GMP binding; Binds the cellulose synthase activator, bis-(3'-5') cyclic diguanylic acid (c-di-GMP); Belongs to the AcsB/BcsB family.


ensembl_gene_id: VF_A0884
symbol: bcsA
gene_biotype: protein_coding
description:
  Cellulose synthase, catalytic subunit; Catalytic subunit of cellulose synthase. It polymerizes uridine 5'-diphosphate glucose to cellulose.


ensembl_gene_id: VF_A0889
symbol: tagD
gene_biotype: protein_coding
description:
  Lipid hydroperoxide peroxidase; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.


ensembl_gene_id: VF_A0890
symbol: VF_A0890
gene_biotype: protein_coding
description:
  Thioredoxin peroxidase; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.


ensembl_gene_id: VF_A0922
symbol: luxD
gene_biotype: protein_coding
description:
  Acyl transferase LuxD; Acyl transferase is part of the fatty acid reductase system required for aldehyde biosynthesis; it produces fatty acids for the luminescent reaction; Belongs to the LuxD family.


ensembl_gene_id: VF_A0923
symbol: luxC
gene_biotype: protein_coding
description:
  acyl-CoA reductase LuxC; LuxC is the fatty acid reductase enzyme responsible for synthesis of the aldehyde substrate for the luminescent reaction catalyzed by luciferase.


ensembl_gene_id: VF_A0924
symbol: luxI
gene_biotype: protein_coding
description:
  3-oxo-C6-HSL autoinducer synthesis protein LuxI; Required for the synthesis of OHHL (N-(3-oxohexanoyl)-L- homoserine lactone) also known as VAI or N-(beta-ketocaproyl)homoserine lactone or 3-oxo-N-(tetrahydro-2-oxo-3-furanyl)-hexanamide, an autoinducer molecule which binds to LuxR and thus acts in bioluminescence regulation.


ensembl_gene_id: VF_A0925
symbol: luxR
gene_biotype: protein_coding
description:
  Autoinducer-binding transcriptional activator protein LuxR; Transcriptional activator of the bioluminescence operon. Binds to the OHHL autoinducer.


ensembl_gene_id: VF_A0969
symbol: guaD
gene_biotype: protein_coding
description:
  Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.


ensembl_gene_id: VF_A0972
symbol: fecD
gene_biotype: protein_coding
description:
  KpLE2 phage-like element; iron-dicitrate transporter subunit; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.


ensembl_gene_id: VF_A0984
symbol: yfhD
gene_biotype: protein_coding
description:
  Predicted transglycosylase; Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella. In the N-terminal section; belongs to the bacterial solute- binding protein 3 family.


ensembl_gene_id: VF_A0990
symbol: VF_A0990
gene_biotype: protein_coding
description:
  trimethylamine-N-oxide reductase; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.


ensembl_gene_id: VF_A0997
symbol: kduD
gene_biotype: protein_coding
description:
  2-deoxy-D-gluconate 3-dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family.


ensembl_gene_id: VF_A0998
symbol: kduI
gene_biotype: protein_coding
description:
  Predicted 5-keto 4-deoxyuronate isomerase; Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate. Belongs to the KduI family.


ensembl_gene_id: VF_A1015
symbol: rpoQ
gene_biotype: protein_coding
description:
  sigma-Q factor RpoQ, quorum-sensing regulated RpoS-like sigma subunit; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.


ensembl_gene_id: VF_A1122
symbol: ectA
gene_biotype: protein_coding
description:
  L-2,4-diaminobutyric acid acetyltransferase; Catalyzes the acetylation of L-2,4-diaminobutyrate (DABA) to gamma-N-acetyl-alpha,gamma-diaminobutyric acid (ADABA) with acetyl coenzyme A.


ensembl_gene_id: VF_A1123
symbol: ectB
gene_biotype: protein_coding
description:
  Diaminobutyrate--2-oxoglutarate aminotransferase; Catalyzes reversively the conversion of L-aspartate beta- semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.


ensembl_gene_id: VF_A1124
symbol: ectC
gene_biotype: protein_coding
description:
  Ectoine synthase; Catalyzes the circularization of gamma-N-acetyl-alpha,gamma- diaminobutyric acid (ADABA) to ectoine (1,4,5,6-tetrahydro-2-methyl-4- pyrimidine carboxylic acid), which is an excellent osmoprotectant.


ensembl_gene_id: VF_A1153
symbol: ybiN
gene_biotype: protein_coding
description:
  Predicted SAM-dependent methyltransferase; Specifically methylates the adenine in position 1618 of 23S rRNA.


ensembl_gene_id: VF_A1161
symbol: pdxH
gene_biotype: protein_coding
description:
  Pyridoxine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).


ensembl_gene_id: VF_A1169
symbol: ypfI
gene_biotype: protein_coding
description:
  Predicted hydrolase; Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).


ensembl_gene_id: VF_A1189
symbol: bioB
gene_biotype: protein_coding
description:
  Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family.


