# geneInfo

ensembl_gene_id: Spro_0002
symbol: atpB
gene_biotype: protein_coding
description:
  ATP synthase F0, A subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.


ensembl_gene_id: Spro_0003
symbol: atpE
gene_biotype: protein_coding
description:
  ATP synthase F0, C subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.


ensembl_gene_id: Spro_0004
symbol: atpF
gene_biotype: protein_coding
description:
  ATP synthase F0, B subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.


ensembl_gene_id: Spro_0005
symbol: atpH
gene_biotype: protein_coding
description:
  ATP synthase F1, delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family.


ensembl_gene_id: Spro_0006
symbol: atpA
gene_biotype: protein_coding
description:
  ATP synthase F1, alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family.


ensembl_gene_id: Spro_0007
symbol: atpG
gene_biotype: protein_coding
description:
  ATP synthase F1, gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.


ensembl_gene_id: Spro_0008
symbol: atpD
gene_biotype: protein_coding
description:
  ATP synthase F1, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family.


ensembl_gene_id: Spro_0009
symbol: atpC
gene_biotype: protein_coding
description:
  ATP synthase F1, epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane.


ensembl_gene_id: Spro_0010
symbol: glmU
gene_biotype: protein_coding
description:
  UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family.


ensembl_gene_id: Spro_0011
symbol: glmS
gene_biotype: protein_coding
description:
  Glucosamine--fructose-6-phosphate aminotransferase, isomerizing; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.


ensembl_gene_id: Spro_0012
symbol: Spro_0012
gene_biotype: protein_coding
description:
  Phosphate ABC transporter, periplasmic phosphate-binding protein; Part of the ABC transporter complex PstSACB involved in phosphate import; Belongs to the PstS family.


ensembl_gene_id: Spro_0013
symbol: Spro_0013
gene_biotype: protein_coding
description:
  Phosphate ABC transporter, inner membrane subunit PstC; Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.


ensembl_gene_id: Spro_0014
symbol: Spro_0014
gene_biotype: protein_coding
description:
  TIGRFAM: phosphate ABC transporter, inner membrane subunit PstA; PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: ypi:YpsIP31758_4169 phosphate ABC transporter, permease protein PstA.


ensembl_gene_id: Spro_0015
symbol: pstB
gene_biotype: protein_coding
description:
  Phosphate ABC transporter, ATPase subunit; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.


ensembl_gene_id: Spro_0016
symbol: Spro_0016
gene_biotype: protein_coding
description:
  Phosphate uptake regulator, PhoU; Part of the phosphate (Pho) regulon, which plays a key role in phosphate homeostasis. PhoU is essential for the repression of the Pho regulon at high phosphate conditions.


ensembl_gene_id: Spro_0017
symbol: Spro_0017
gene_biotype: protein_coding
description:
  PFAM: extracellular solute-binding protein family 3; KEGG: yen:YE4193 putative periplasmic solute-binding protein; Belongs to the bacterial solute-binding protein 3 family.


ensembl_gene_id: Spro_0018
symbol: Spro_0018
gene_biotype: protein_coding
description:
  TIGRFAM: polar amino acid ABC transporter, inner membrane subunit; PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: yen:YE4191 ABC transporter permease.


ensembl_gene_id: Spro_0019
symbol: Spro_0019
gene_biotype: protein_coding
description:
  TIGRFAM: polar amino acid ABC transporter, inner membrane subunit; PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: yen:YE4190 putative amino acid transport system permease.


ensembl_gene_id: Spro_0020
symbol: Spro_0020
gene_biotype: protein_coding
description:
  TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; HAD-superfamily hydrolase, subfamily IA, variant 1; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: yen:YE4189 putative haloacid dehalogenase-like hydrolase.


ensembl_gene_id: Spro_0021
symbol: Spro_0021
gene_biotype: protein_coding
description:
  PFAM: Xanthine/uracil/vitamin C permease; sulphate transporter; KEGG: yps:YPTB3953 xanthine/uracil permease family protein.


ensembl_gene_id: Spro_0026
symbol: Spro_0026
gene_biotype: protein_coding
description:
  PFAM: beta-lactamase domain protein; KEGG: sec:SC2881 putative metal-dependent hydrolase of the beta-lactamase superfamily II.


ensembl_gene_id: Spro_0027
symbol: mnmE
gene_biotype: protein_coding
description:
  tRNA modification GTPase TrmE; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.


ensembl_gene_id: Spro_0028
symbol: yidC
gene_biotype: protein_coding
description:
  60 kDa inner membrane insertion protein; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.


ensembl_gene_id: Spro_0029
symbol: Spro_0029
gene_biotype: protein_coding
description:
  Protein of unknown function DUF37; Could be involved in insertion of integral membrane proteins into the membrane; Belongs to the UPF0161 family.


ensembl_gene_id: Spro_0030
symbol: rnpA
gene_biotype: protein_coding
description:
  Ribonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.


ensembl_gene_id: Spro_0031
symbol: rpmH
gene_biotype: protein_coding
description:
  PFAM: ribosomal protein L34; KEGG: kpn:KPN_04106 50S ribosomal protein L34; Belongs to the bacterial ribosomal protein bL34 family.


ensembl_gene_id: Spro_0032
symbol: dnaA
gene_biotype: protein_coding
description:
  Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.


ensembl_gene_id: Spro_0033
symbol: Spro_0033
gene_biotype: protein_coding
description:
  DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]


ensembl_gene_id: Spro_0034
symbol: recF
gene_biotype: protein_coding
description:
  DNA replication and repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.


ensembl_gene_id: Spro_0035
symbol: gyrB
gene_biotype: protein_coding
description:
  DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.


ensembl_gene_id: Spro_0036
symbol: Spro_0036
gene_biotype: protein_coding
description:
  TIGRFAM: Cof-like hydrolase; HAD-superfamily hydrolase, subfamily IIB; PFAM: Haloacid dehalogenase domain protein hydrolase; sucrose-6F-phosphate phosphohydrolase; Haloacid dehalogenase domain protein hydrolase type 3; KEGG: yen:YE4169 putative haloacid dehalogenase-like hydrolase.


ensembl_gene_id: Spro_0037
symbol: Spro_0037
gene_biotype: protein_coding
description:
  PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: yen:YE4167 pyridoxal-phosphate dependent enzyme.


ensembl_gene_id: Spro_0039
symbol: Spro_0039
gene_biotype: protein_coding
description:
  PFAM: major facilitator superfamily MFS_1; KEGG: bch:Bcen2424_3541 major facilitator superfamily MFS_1.


ensembl_gene_id: Spro_0040
symbol: Spro_0040
gene_biotype: protein_coding
description:
  PFAM: D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; KEGG: pol:Bpro_3531 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding.


ensembl_gene_id: Spro_0041
symbol: Spro_0041
gene_biotype: protein_coding
description:
  PFAM: regulatory protein GntR HTH; GntR domain protein; KEGG: eca:ECA4419 galactonate operon transcriptional repressor.


ensembl_gene_id: Spro_0042
symbol: Spro_0042
gene_biotype: protein_coding
description:
  2-dehydro-3-deoxygalactonokinase; PFAM: 2-keto-3-deoxy-galactonokinase; KEGG: eca:ECA4418 2-dehydro-3-deoxygalactonokinase.


ensembl_gene_id: Spro_0043
symbol: Spro_0043
gene_biotype: protein_coding
description:
  PFAM: KDPG and KHG aldolase; thiamine monophosphate synthase; KEGG: kpn:KPN_04096 putative keto-hydroxyglutarate-aldolase/keto-deoxy-phosphogluconate aldolase.


ensembl_gene_id: Spro_0044
symbol: dgoD
gene_biotype: protein_coding
description:
  Mandelate racemase/muconate lactonizing protein; Catalyzes the dehydration of D-galactonate to 2-keto-3-deoxy- D-galactonate.


ensembl_gene_id: Spro_0045
symbol: Spro_0045
gene_biotype: protein_coding
description:
  TIGRFAM: phosphoglycerate transporter; d-galactonate transporter; PFAM: major facilitator superfamily MFS_1; KEGG: eca:ECA4415 putative D-galactonate transporter.


ensembl_gene_id: Spro_0048
symbol: ibpA
gene_biotype: protein_coding
description:
  Heat shock protein Hsp20; Associates with aggregated proteins, together with IbpB, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK/DnaJ/GrpE. Its activity is ATP-independent.


ensembl_gene_id: Spro_0049
symbol: ibpB
gene_biotype: protein_coding
description:
  Heat shock protein Hsp20; Associates with aggregated proteins, together with IbpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK/DnaJ/GrpE. Its activity is ATP-independent.


ensembl_gene_id: Spro_0050
symbol: Spro_0050
gene_biotype: protein_coding
description:
  TIGRFAM: YidE/YbjL duplication; PFAM: TrkA-C domain protein; YidE/YbjL duplication domain protein; KEGG: ypp:YPDSF_0014 membrane protein.


ensembl_gene_id: Spro_0054
symbol: Spro_0054
gene_biotype: protein_coding
description:
  PFAM: alpha amylase catalytic region; SMART: alpha amylase catalytic sub domain; KEGG: ypi:YpsIP31758_4138 alpha-amylase.


ensembl_gene_id: Spro_0055
symbol: Spro_0055
gene_biotype: protein_coding
description:
  Transcriptional regulator, CopG family; PFAM: CopG domain protein DNA-binding domain protein; KEGG: eca:ECA2757 hypothetical protein.


ensembl_gene_id: Spro_0057
symbol: ghrB
gene_biotype: protein_coding
description:
  D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrB subfamily.


ensembl_gene_id: Spro_0058
symbol: Spro_0058
gene_biotype: protein_coding
description:
  PFAM: General substrate transporter; major facilitator superfamily MFS_1; KEGG: ent:Ent638_0168 major facilitator superfamily MFS_1.


ensembl_gene_id: Spro_0060
symbol: Spro_0060
gene_biotype: protein_coding
description:
  PFAM: Xylose isomerase domain protein TIM barrel; KEGG: kpn:KPN_03912 putative sugar phosphate isomerase/epimerase.


ensembl_gene_id: Spro_0061
symbol: Spro_0061
gene_biotype: protein_coding
description:
  Transcriptional regulator, LacI family; PFAM: regulatory protein LacI; periplasmic binding protein/LacI transcriptional regulator; KEGG: kpn:KPN_03911 putative transcriptional regulator.


ensembl_gene_id: Spro_0064
symbol: Spro_0064
gene_biotype: protein_coding
description:
  KEGG: yen:YE4152 DNA-3-methyladenine glycosylase; TIGRFAM: DNA-3-methyladenine glycosylase I; PFAM: methyladenine glycosylase.


ensembl_gene_id: Spro_0065
symbol: Spro_0065
gene_biotype: protein_coding
description:
  KEGG: spt:SPA2157 outer membrane esterase; TIGRFAM: outer membrane autotransporter barrel domain; PFAM: lipolytic protein G-D-S-L family; Autotransporter beta- domain protein.


ensembl_gene_id: Spro_0066
symbol: Spro_0066
gene_biotype: protein_coding
description:
  Transcriptional regulator, LuxR family; PFAM: regulatory protein LuxR; Autoinducer-binding domain protein; KEGG: yen:YE1026 LuxR-family transcriptional regulator.


ensembl_gene_id: Spro_0068
symbol: Spro_0068
gene_biotype: protein_coding
description:
  PFAM: major facilitator superfamily MFS_1; KEGG: bmb:BruAb1_1939 major facilitator family transporter.


ensembl_gene_id: Spro_0069
symbol: glyQ
gene_biotype: protein_coding
description:
  KEGG: ypi:YpsIP31758_4131 glycyl-tRNA synthetase, alpha subunit; TIGRFAM: glycyl-tRNA synthetase, alpha subunit; PFAM: glycyl-tRNA synthetase alpha subunit.


ensembl_gene_id: Spro_0070
symbol: glyS
gene_biotype: protein_coding
description:
  KEGG: ypi:YpsIP31758_4130 glycyl-tRNA synthetase, beta subunit; TIGRFAM: glycyl-tRNA synthetase, beta subunit.


ensembl_gene_id: Spro_0072
symbol: Spro_0072
gene_biotype: protein_coding
description:
  TIGRFAM: PTS system, mannitol-specific IIC subunit; PFAM: phosphoenolpyruvate-dependent sugar phosphotransferase system EIIA 2; phosphotransferase system EIIC; phosphotransferase system lactose/cellobiose-specific IIB subunit; KEGG: yen:YE4148 PTS system, mannitol-specific IIABC component.


ensembl_gene_id: Spro_0073
symbol: mtlD
gene_biotype: protein_coding
description:
  PFAM: Mannitol dehydrogenase domain; Mannitol dehydrogenase rossman domain; KEGG: yen:YE4147 mannitol-1-phosphate 5-dehydrogenase.


ensembl_gene_id: Spro_0076
symbol: Spro_0076
gene_biotype: protein_coding
description:
  Transcriptional regulator, GntR family with aminotransferase domain; PFAM: regulatory protein GntR HTH; aminotransferase class I and II; KEGG: yen:YE4144 putative transcriptional regulator.


ensembl_gene_id: Spro_0078
symbol: Spro_0078
gene_biotype: protein_coding
description:
  PFAM: Methyltransferase type 11; Methyltransferase type 12; KEGG: pfo:Pfl_2883 hypothetical protein.


ensembl_gene_id: Spro_0079
symbol: Spro_0079
gene_biotype: protein_coding
description:
  PFAM: 3-alpha domain protein; MOSC domain containing protein; KEGG: yen:YE4140 hypothetical protein.


ensembl_gene_id: Spro_0080
symbol: Spro_0080
gene_biotype: protein_coding
description:
  PFAM: histidine kinase HAMP region domain protein; chemotaxis sensory transducer; KEGG: yen:YE4139 methyl-accepting chemotaxis protein II.


ensembl_gene_id: Spro_0081
symbol: Spro_0081
gene_biotype: protein_coding
description:
  Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.


ensembl_gene_id: Spro_0082
symbol: fdhD
gene_biotype: protein_coding
description:
  Formate dehydrogenase family accessory protein FdhD; Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Belongs to the FdhD family.


ensembl_gene_id: Spro_0083
symbol: Spro_0083
gene_biotype: protein_coding
description:
  PFAM: molybdopterin oxidoreductase Fe4S4 region; KEGG: ypi:YpsIP31758_4119 aerobic formate dehydrogenase, alpha subunit, proteobacterial-type.


ensembl_gene_id: Spro_0084
symbol: Spro_0084
gene_biotype: protein_coding
description:
  KEGG: yen:YE4135 formate dehydrogenase-o, major subunit; TIGRFAM: formate dehydrogenase, alpha subunit; PFAM: molybdopterin oxidoreductase; molydopterin dinucleotide-binding region; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.


ensembl_gene_id: Spro_0085
symbol: Spro_0085
gene_biotype: protein_coding
description:
  Formate dehydrogenase, beta subunit; The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers.


ensembl_gene_id: Spro_0086
symbol: Spro_0086
gene_biotype: protein_coding
description:
  TIGRFAM: formate dehydrogenase, gamma subunit; PFAM: cytochrome B561; KEGG: yen:YE4133 formate dehydrogenase, cytochrome b556 protein.


ensembl_gene_id: Spro_0087
symbol: fdhE
gene_biotype: protein_coding
description:
  Formate dehydrogenase accessory protein FdhE; Necessary for formate dehydrogenase activity. Belongs to the FdhE family.


ensembl_gene_id: Spro_0089
symbol: Spro_0089
gene_biotype: protein_coding
description:
  PFAM: Glutathione S-transferase domain; KEGG: ent:Ent638_0139 glutathione S-transferase, C-terminal domain.


ensembl_gene_id: Spro_0090
symbol: selA
gene_biotype: protein_coding
description:
  L-seryl-tRNA(Sec) selenium transferase; Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis; Belongs to the SelA family.


ensembl_gene_id: Spro_0091
symbol: Spro_0091
gene_biotype: protein_coding
description:
  TIGRFAM: selenocysteine-specific translation elongation factor; PFAM: protein synthesis factor GTP-binding; elongation factor Tu domain 2 protein; Elongation factor SelB winged helix 2; Elongation factor SelB winged helix 3; KEGG: yen:YE4130 selenocysteinyl-tRNA-specific translation factor.


ensembl_gene_id: Spro_0093
symbol: wecH
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Responsible for the incorporation of O-acetyl groups into the enterobacterial common antigen (ECA) trisaccharide repeat units.


ensembl_gene_id: Spro_0094
symbol: Spro_0094
gene_biotype: protein_coding
description:
  Transcriptional regulator, AraC family; PFAM: helix-turn-helix- domain containing protein AraC type; ThiJ/PfpI domain protein; KEGG: yen:YE4125 putative transcriptional regulator.


ensembl_gene_id: Spro_0095
symbol: Spro_0095
gene_biotype: protein_coding
description:
  PFAM: isochorismatase hydrolase; KEGG: yen:YE4124 putative member of isochorismatase hydrolase family.


ensembl_gene_id: Spro_0098
symbol: xylA
gene_biotype: protein_coding
description:
  KEGG: ypi:YpsIP31758_4102 xylose isomerase; TIGRFAM: xylose isomerase; PFAM: Xylose isomerase domain protein TIM barrel; Belongs to the xylose isomerase family.


ensembl_gene_id: Spro_0099
symbol: Spro_0099
gene_biotype: protein_coding
description:
  KEGG: yps:YPTB3890 ABC transporter, periplasmic xylose binding protein; TIGRFAM: D-xylose ABC transporter, periplasmic substrate-binding protein; PFAM: periplasmic binding protein/LacI transcriptional regulator.


ensembl_gene_id: Spro_0100
symbol: xylG
gene_biotype: protein_coding
description:
  D-xylose ABC transporter, ATPase subunit; Part of the ABC transporter complex XylFGH involved in xylose import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Xylose importer (TC 3.A.1.2.4) family.


ensembl_gene_id: Spro_0101
symbol: Spro_0101
gene_biotype: protein_coding
description:
  Monosaccharide-transporting ATPase; PFAM: inner-membrane translocator; KEGG: yen:YE4119 sugar transport system permease protein.


ensembl_gene_id: Spro_0102
symbol: Spro_0102
gene_biotype: protein_coding
description:
  Transcriptional regulator, AraC family; PFAM: helix-turn-helix- domain containing protein AraC type; KEGG: ypi:YpsIP31758_4098 xylose operon regulatory protein.


ensembl_gene_id: Spro_0105
symbol: Spro_0105
gene_biotype: protein_coding
description:
  Transcriptional regulator, LysR family; PFAM: regulatory protein LysR; LysR substrate-binding; KEGG: pap:PSPA7_2742 probable transcriptional regulator.


ensembl_gene_id: Spro_0108
symbol: Spro_0108
gene_biotype: protein_coding
description:
  PFAM: integrase family protein; KEGG: ypp:YPDSF_3775 phage integrase; Belongs to the 'phage' integrase family.


ensembl_gene_id: Spro_0112
symbol: Spro_0112
gene_biotype: protein_coding
description:
  Transcriptional regulator, GntR family with aminotransferase domain; PFAM: regulatory protein GntR HTH; aminotransferase class I and II; KEGG: syf:Synpcc7942_1725 regulatory protein GntR, HTH.


ensembl_gene_id: Spro_0115
symbol: Spro_0115
gene_biotype: protein_coding
description:
  PFAM: secretion protein HlyD family protein; KEGG: ent:Ent638_0138 secretion protein HlyD family protein.


ensembl_gene_id: Spro_0120
symbol: Spro_0120
gene_biotype: protein_coding
description:
  Transcriptional regulator, LacI family; PFAM: regulatory protein LacI; periplasmic binding protein/LacI transcriptional regulator; KEGG: pol:Bpro_4573 transcriptional regulator, LacI family.


ensembl_gene_id: Spro_0121
symbol: Spro_0121
gene_biotype: protein_coding
description:
  PFAM: short-chain dehydrogenase/reductase SDR; KEGG: csa:Csal_1758 short-chain dehydrogenase/reductase SDR.


ensembl_gene_id: Spro_0122
symbol: Spro_0122
gene_biotype: protein_coding
description:
  TIGRFAM: TRAP dicarboxylate transporter, DctM subunit; PFAM: Tripartite ATP-independent periplasmic transporter DctQ component; TRAP C4-dicarboxylate transport system permease DctM subunit; KEGG: bte:BTH_II0984 TRAP transporter, DctM subunit subfamily, putative.


ensembl_gene_id: Spro_0123
symbol: Spro_0123
gene_biotype: protein_coding
description:
  TIGRFAM: TRAP dicarboxylate transporter, DctP subunit; PFAM: TRAP dicarboxylate transporter- DctP subunit; KEGG: bte:BTH_II0985 bacterial extracellular solute-binding protein, family 7 superfamily.


ensembl_gene_id: Spro_0125
symbol: Spro_0125
gene_biotype: protein_coding
description:
  PFAM: NAD-dependent epimerase/dehydratase; short-chain dehydrogenase/reductase SDR; 3-beta hydroxysteroid dehydrogenase/isomerase; polysaccharide biosynthesis protein CapD; dTDP-4-dehydrorhamnose reductase; KEGG: pfl:PFL_4587 TDP-glucose-4,6-dehydratase-related protein.


ensembl_gene_id: Spro_0126
symbol: Spro_0126
gene_biotype: protein_coding
description:
  Transcriptional regulator, LysR family; PFAM: regulatory protein LysR; LysR substrate-binding; KEGG: bbt:BBta_7356 putative transcriptional regulator, LysR family.


ensembl_gene_id: Spro_0127
symbol: Spro_0127
gene_biotype: protein_coding
description:
  PFAM: short-chain dehydrogenase/reductase SDR; KR domain protein; KEGG: bxe:Bxe_B2157 putative short-chain dehydrogenase/reductase SDR.


ensembl_gene_id: Spro_0128
symbol: Spro_0128
gene_biotype: protein_coding
description:
  SMART: metal-dependent phosphohydrolase HD region; KEGG: hch:HCH_02572 guanosine polyphosphate pyrophosphohydrolase/synthetases.


ensembl_gene_id: Spro_0132
symbol: Spro_0132
gene_biotype: protein_coding
description:
  Two component transcriptional regulator, LuxR family; PFAM: regulatory protein LuxR; response regulator receiver; KEGG: ypi:YpsIP31758_4080 transcriptional regulatory protein UhpA.


ensembl_gene_id: Spro_0133
symbol: Spro_0133
gene_biotype: protein_coding
description:
  Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; MASE1 domain protein; histidine kinase dimerisation and phosphoacceptor region; KEGG: ypi:YpsIP31758_4079 sensor histidine kinase UhpB.


ensembl_gene_id: Spro_0134
symbol: Spro_0134
gene_biotype: protein_coding
description:
  TIGRFAM: phosphoglycerate transporter; PFAM: major facilitator superfamily MFS_1; KEGG: yen:YE4087 putative regulatory protein.


ensembl_gene_id: Spro_0137
symbol: Spro_0137
gene_biotype: protein_coding
description:
  Chitinase; KEGG: sbl:Sbal_3083 chitinase; PFAM: glycoside hydrolase family 18; Chitinase A domain protein; SMART: PKD domain containing protein; chitinase II; Belongs to the glycosyl hydrolase 18 family.


ensembl_gene_id: Spro_0138
symbol: Spro_0138
gene_biotype: protein_coding
description:
  PFAM: extracellular solute-binding protein family 5; KEGG: yen:YE4083 periplasmic dipeptide transport protein.


ensembl_gene_id: Spro_0139
symbol: Spro_0139
gene_biotype: protein_coding
description:
  Alkaline phosphatase; PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: yen:YE4082 dipeptide transport system permease protein.


ensembl_gene_id: Spro_0140
symbol: Spro_0140
gene_biotype: protein_coding
description:
  PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: yen:YE4081 dipeptide transport system permease protein.


ensembl_gene_id: Spro_0141
symbol: Spro_0141
gene_biotype: protein_coding
description:
  KEGG: yen:YE4080 dipeptide transport ATP-binding protein; TIGRFAM: oligopeptide/dipeptide ABC transporter, ATPase subunit; PFAM: ABC transporter related; Oligopeptide/dipeptide ABC transporter domain protein; SMART: AAA ATPase; Belongs to the ABC transporter superfamily.


ensembl_gene_id: Spro_0142
symbol: Spro_0142
gene_biotype: protein_coding
description:
  Oligopeptide/dipeptide ABC transporter, ATPase subunit; KEGG: ypi:YpsIP31758_4071 dipeptide ABC transporter, ATP-binding protein DppF; TIGRFAM: oligopeptide/dipeptide ABC transporter, ATPase subunit; PFAM: ABC transporter related; Oligopeptide/dipeptide ABC transporter domain protein; SMART: AAA ATPase; Belongs to the ABC transporter superfamily.


ensembl_gene_id: Spro_0148
symbol: Spro_0148
gene_biotype: protein_coding
description:
  Cellulose synthase (UDP-forming); Catalytic subunit of cellulose synthase. It polymerizes uridine 5'-diphosphate glucose to cellulose.


ensembl_gene_id: Spro_0149
symbol: Spro_0149
gene_biotype: protein_coding
description:
  Cellulose synthase subunit B; Binds the cellulose synthase activator, bis-(3'-5') cyclic diguanylic acid (c-di-GMP); Belongs to the AcsB/BcsB family.


ensembl_gene_id: Spro_0150
symbol: Spro_0150
gene_biotype: protein_coding
description:
  Cellulase; PFAM: glycoside hydrolase family 8; KEGG: yen:YE4072A endoglucanase precursor (endo-1,4-beta-glucanase involved in cellulose degradation).


ensembl_gene_id: Spro_0151
symbol: Spro_0151
gene_biotype: protein_coding
description:
  PFAM: TPR repeat-containing protein; cellulose synthase operon C domain protein; Tetratricopeptide TPR_4; Tetratricopeptide TPR_2 repeat protein; SMART: Tetratricopeptide domain protein; KEGG: yen:YE4072 probable BcsC protein involved in cellulose synthesis.


ensembl_gene_id: Spro_0152
symbol: Spro_0152
gene_biotype: protein_coding
description:
  TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; EAL domain protein; histidine kinase HAMP region domain protein; KEGG: ypp:YPDSF_3363 membrane protein.


ensembl_gene_id: Spro_0153
symbol: dctA
gene_biotype: protein_coding
description:
  Sodium:dicarboxylate symporter; Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane. Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.


ensembl_gene_id: Spro_0155
symbol: Spro_0155
gene_biotype: protein_coding
description:
  PFAM: PpiC-type peptidyl-prolyl cis-trans isomerase; KEGG: kpn:KPN_04275 peptidyl-prolyl cis-trans isomerase C (rotamase C).


ensembl_gene_id: Spro_0156
symbol: rep
gene_biotype: protein_coding
description:
  ATP-dependent DNA helicase Rep; Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replication; it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction.


ensembl_gene_id: Spro_0157
symbol: gppA
gene_biotype: protein_coding
description:
  Ppx/GppA phosphatase; Catalyzes the conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the 'stringent response', an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.


ensembl_gene_id: Spro_0158
symbol: rhlB
gene_biotype: protein_coding
description:
  DEAD/DEAH box helicase domain protein; DEAD-box RNA helicase involved in RNA degradation. Has RNA- dependent ATPase activity and unwinds double-stranded RNA. Belongs to the DEAD box helicase family. RhlB subfamily.


ensembl_gene_id: Spro_0159
symbol: Spro_0159
gene_biotype: protein_coding
description:
  TIGRFAM: thioredoxin; PFAM: Thioredoxin domain; KEGG: sdy:SDY_3968 thioredoxin 1; Belongs to the thioredoxin family.


ensembl_gene_id: Spro_0160
symbol: rho
gene_biotype: protein_coding
description:
  Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template.


ensembl_gene_id: Spro_0161
symbol: wecA
gene_biotype: protein_coding
description:
  Undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP-C55).


ensembl_gene_id: Spro_0162
symbol: wzzE
gene_biotype: protein_coding
description:
  Lipopolysaccharide biosynthesis protein; Modulates the polysaccharide chain length of enterobacterial common antigen (ECA); Belongs to the WzzB/Cld/Rol family.


ensembl_gene_id: Spro_0163
symbol: wecB
gene_biotype: protein_coding
description:
  UDP-N-acetylglucosamine 2-epimerase; Catalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) and thereby provides bacteria with UDP- N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues.


ensembl_gene_id: Spro_0164
symbol: wecC
gene_biotype: protein_coding
description:
  UDP-glucose/GDP-mannose dehydrogenase; Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N- acetylmannosaminuronic acid (UDP-ManNAcA); Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. WecC subfamily.


ensembl_gene_id: Spro_0165
symbol: Spro_0165
gene_biotype: protein_coding
description:
  TIGRFAM: dTDP-glucose 4,6-dehydratase; PFAM: NAD-dependent epimerase/dehydratase; short-chain dehydrogenase/reductase SDR; 3-beta hydroxysteroid dehydrogenase/isomerase; polysaccharide biosynthesis protein CapD; dTDP-4-dehydrorhamnose reductase; Male sterility domain; KEGG: ypi:YpsIP31758_0186 dTDP-glucose 4,6-dehydratase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.


ensembl_gene_id: Spro_0166
symbol: Spro_0166
gene_biotype: protein_coding
description:
  Glucose-1-phosphate thymidylyltransferase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family.


ensembl_gene_id: Spro_0167
symbol: wecD
gene_biotype: protein_coding
description:
  TDP-D-fucosamine acetyltransferase; Catalyzes the acetylation of dTDP-fucosamine (dTDP-4-amino- 4,6-dideoxy-D-galactose) to dTDP-Fuc4NAc, which is utilized in the biosynthesis of the enterobacterial common antigen (ECA). Belongs to the WecD family.


ensembl_gene_id: Spro_0168
symbol: wecE
gene_biotype: protein_coding
description:
  TDP-4-keto-6-deoxy-D-glucose transaminase; Catalyzes the synthesis of dTDP-4-amino-4,6-dideoxy-D- galactose (dTDP-Fuc4N) from dTDP-4-keto-6-deoxy-D-glucose (dTDP-D- Glc4O) and L-glutamate; Belongs to the DegT/DnrJ/EryC1 family.


ensembl_gene_id: Spro_0169
symbol: wzxE
gene_biotype: protein_coding
description:
  Polysaccharide biosynthesis protein; Mediates the transbilayer movement of Und-PP-GlcNAc-ManNAcA- Fuc4NAc (lipid III) from the inner to the outer leaflet of the cytoplasmic membrane during the assembly of enterobacterial common antigen (ECA); Belongs to the polysaccharide transport (PST) (TC 2.A.66.2) family.


ensembl_gene_id: Spro_0170
symbol: wecF
gene_biotype: protein_coding
description:
  4-alpha-L-fucosyltransferase; Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis; Belongs to the glycosyltransferase 56 family.


ensembl_gene_id: Spro_0171
symbol: wzyE
gene_biotype: protein_coding
description:
  WzyE family protein; Probably involved in the polymerization of enterobacterial common antigen (ECA) trisaccharide repeat units; Belongs to the WzyE family.


ensembl_gene_id: Spro_0172
symbol: wecG
gene_biotype: protein_coding
description:
  Glycosyl transferase, WecB/TagA/CpsF family; Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA (Lipid II), the second lipid-linked intermediate involved in enterobacterial common antigen (ECA) synthesis.


ensembl_gene_id: Spro_0175
symbol: Spro_0175
gene_biotype: protein_coding
description:
  TIGRFAM: HemY protein; PFAM: HemY domain protein; Tetratricopeptide TPR_2 repeat protein; KEGG: yen:YE0184 putative protoheme IX biogenesis protein.


ensembl_gene_id: Spro_0176
symbol: Spro_0176
gene_biotype: protein_coding
description:
  PFAM: protein of unknown function DUF513 hemX; KEGG: yen:YE0185 putative uroporphyrin-III C-methyltransferase.


ensembl_gene_id: Spro_0177
symbol: Spro_0177
gene_biotype: protein_coding
description:
  Uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.


ensembl_gene_id: Spro_0178
symbol: hemC
gene_biotype: protein_coding
description:
  Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.


ensembl_gene_id: Spro_0179
symbol: Spro_0179
gene_biotype: protein_coding
description:
  PFAM: adenylate cyclase class-I; KEGG: yen:YE0189 adenylate cyclase; Belongs to the adenylyl cyclase class-1 family.


ensembl_gene_id: Spro_0180
symbol: cyaY
gene_biotype: protein_coding
description:
  Frataxin family protein; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis.


ensembl_gene_id: Spro_0182
symbol: dapF
gene_biotype: protein_coding
description:
  Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan.


ensembl_gene_id: Spro_0184
symbol: xerC
gene_biotype: protein_coding
description:
  Tyrosine recombinase XerC; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Binds cooperatively to specific DNA consensus sequences that are separated from XerD binding sites by a short central region, forming the heterotetrameric XerC-XerD complex that recombines DNA substrates. The complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. In the complex XerC specifically exchanges t [...]


ensembl_gene_id: Spro_0185
symbol: Spro_0185
gene_biotype: protein_coding
description:
  TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; HAD-superfamily hydrolase, subfamily IA, variant 1; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: yen:YE0195 putative haloacid dehalogenase-like hydrolase.


ensembl_gene_id: Spro_0188
symbol: corA
gene_biotype: protein_coding
description:
  Magnesium and cobalt transport protein CorA; Mediates influx of magnesium ions. Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.


ensembl_gene_id: Spro_0190
symbol: Spro_0190
gene_biotype: protein_coding
description:
  TIGRFAM: RarD protein, DMT superfamily transporter; PFAM: protein of unknown function DUF6 transmembrane; KEGG: ypi:YpsIP31758_0215 RarD protein.


ensembl_gene_id: Spro_0192
symbol: Spro_0192
gene_biotype: protein_coding
description:
  Phospholipase A(1); Hydrolysis of phosphatidylcholine with phospholipase A2 (EC 3.1.1.4) and phospholipase A1 (EC 3.1.1.32) activities. Belongs to the phospholipase A1 family.


ensembl_gene_id: Spro_0193
symbol: Spro_0193
gene_biotype: protein_coding
description:
  KEGG: ypi:YpsIP31758_0218 ATP-dependent DNA helicase RecQ; TIGRFAM: ATP-dependent DNA helicase, RecQ family; ATP-dependent DNA helicase RecQ; PFAM: helicase domain protein; HRDC domain protein; DEAD/DEAH box helicase domain protein; Helicase superfamily 1 and 2 ATP-binding; SMART: DEAD-like helicases.


ensembl_gene_id: Spro_0194
symbol: Spro_0194
gene_biotype: protein_coding
description:
  TIGRFAM: homoserine/threonine efflux pump; PFAM: Lysine exporter protein (LYSE/YGGA); KEGG: yen:YE0205 threonine efflux protein.


ensembl_gene_id: Spro_0195
symbol: Spro_0195
gene_biotype: protein_coding
description:
  PFAM: Lysine exporter protein (LYSE/YGGA); KEGG: eca:ECA4170 homoserine/homoserine lactone efflux protein.


ensembl_gene_id: Spro_0197
symbol: Spro_0197
gene_biotype: protein_coding
description:
  TIGRFAM: Cof-like hydrolase; HAD-superfamily hydrolase, subfamily IIB; PFAM: Haloacid dehalogenase domain protein hydrolase; sucrose-6F-phosphate phosphohydrolase; Haloacid dehalogenase domain protein hydrolase type 3; KEGG: yen:YE0208 putative haloacid dehalogenase-like hydrolase.


ensembl_gene_id: Spro_0198
symbol: Spro_0198
gene_biotype: protein_coding
description:
  PFAM: glycerophosphoryl diester phosphodiesterase; KEGG: yen:YE0209 glycerophosphoryl diester phosphodiesterase.


ensembl_gene_id: Spro_0199
symbol: Spro_0199
gene_biotype: protein_coding
description:
  TIGRFAM: phosphoglycerate transporter; glycerol-3-phosphate transporter; PFAM: major facilitator superfamily MFS_1; KEGG: yen:YE0210 glycerol-3-phosphate transporter.


ensembl_gene_id: Spro_0200
symbol: Spro_0200
gene_biotype: protein_coding
description:
  PFAM: FAD dependent oxidoreductase; BFD domain protein [2Fe-2S]-binding domain protein; KEGG: yen:YE0212 anaerobic glycerol-3-phosphate dehydrogenase subunit A; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.


ensembl_gene_id: Spro_0201
symbol: glpB
gene_biotype: protein_coding
description:
  Glycerol-3-phosphate dehydrogenase; Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor.


ensembl_gene_id: Spro_0202
symbol: Spro_0202
gene_biotype: protein_coding
description:
  PFAM: protein of unknown function DUF224 cysteine-rich region domain protein; KEGG: yen:YE0214 anaerobic glycerol-3-phosphate dehydrogenase subunit C.


ensembl_gene_id: Spro_0204
symbol: Spro_0204
gene_biotype: protein_coding
description:
  Conserved hypothetical integral membrane protein; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.


ensembl_gene_id: Spro_0205
symbol: tusA
gene_biotype: protein_coding
description:
  SirA family protein; Sulfur carrier protein involved in sulfur trafficking in the cell. Part of a sulfur-relay system required for 2-thiolation during synthesis of 2-thiouridine of the modified wobble base 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) in tRNA. Interacts with IscS and stimulates its cysteine desulfurase activity. Accepts an activated sulfur from IscS, which is then transferred to TusD, and thus determines the direction of sulfur flow from IscS to 2-thiouridine formation. Also appears to be involved in sulfur transfer for the biosynthesis of molybdopterin.


ensembl_gene_id: Spro_0209
symbol: Spro_0209
gene_biotype: protein_coding
description:
  Heavy metal translocating P-type ATPase; TIGRFAM: ATPase, P-type (transporting), HAD superfamily, subfamily IC; cadmium-translocating P-type ATPase; heavy metal translocating P-type ATPase; PFAM: Haloacid dehalogenase domain protein hydrolase; Heavy metal transport/detoxification protein; E1-E2 ATPase-associated domain protein; KEGG: yen:YE0218 putative P-type cation-translocating membrane ATPase.


ensembl_gene_id: Spro_0210
symbol: Spro_0210
gene_biotype: protein_coding
description:
  Serralysin; KEGG: eca:ECA2785 metalloprotease; PFAM: Hemolysin-type calcium-binding region; peptidase M10A and M12B matrixin and adamalysin; Peptidase M10 serralysin; SMART: peptidase metallopeptidase.


ensembl_gene_id: Spro_0220
symbol: Spro_0220
gene_biotype: protein_coding
description:
  Putative methyltransferase; Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle; Belongs to the methyltransferase superfamily. RsmD family.


ensembl_gene_id: Spro_0221
symbol: ftsY
gene_biotype: protein_coding
description:
  Signal recognition particle-docking protein FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.


ensembl_gene_id: Spro_0222
symbol: ftsE
gene_biotype: protein_coding
description:
  Type II (General) Secretory Pathway (IISP) Family protein; Part of the ABC transporter FtsEX involved in cellular division.


ensembl_gene_id: Spro_0223
symbol: Spro_0223
gene_biotype: protein_coding
description:
  Putative protein insertion ABC transporter, inner membrane subunit FtsX; Part of the ABC transporter FtsEX involved in cellular division; Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.


ensembl_gene_id: Spro_0224
symbol: rpoH
gene_biotype: protein_coding
description:
  RNA polymerase, sigma 32 subunit, RpoH; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes.


ensembl_gene_id: Spro_0227
symbol: panZ
gene_biotype: protein_coding
description:
  GCN5-related N-acetyltransferase; Controls both the activation and catalytic activity of PanD in a coenzyme A (CoA)-dependent fashion; Belongs to the PanZ/PanM family.


ensembl_gene_id: Spro_0228
symbol: Spro_0228
gene_biotype: protein_coding
description:
  PFAM: Extracellular ligand-binding receptor; KEGG: yen:YE0230 branched-chain amino acid-binding protein.


ensembl_gene_id: Spro_0229
symbol: Spro_0229
gene_biotype: protein_coding
description:
  PFAM: inner-membrane translocator; KEGG: ypi:YpsIP31758_0245 high-affinity branched-chain amino acid ABC transporter, permease protein; Belongs to the binding-protein-dependent transport system permease family.


ensembl_gene_id: Spro_0230
symbol: Spro_0230
gene_biotype: protein_coding
description:
  PFAM: inner-membrane translocator; KEGG: yen:YE0232 high-affinity branched-chain amino acid transport system, permease protein.


ensembl_gene_id: Spro_0231
symbol: Spro_0231
gene_biotype: protein_coding
description:
  ABC transporter-related protein; PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: yen:YE0233 high-affinity branched-chain amino acid transport, ATP-binding protein.


ensembl_gene_id: Spro_0232
symbol: Spro_0232
gene_biotype: protein_coding
description:
  ABC transporter-related protein; PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: yen:YE0234 high-affinity branched-chain amino acid transport, ATP-binding protein; Belongs to the ABC transporter superfamily.


ensembl_gene_id: Spro_0233
symbol: Spro_0233
gene_biotype: protein_coding
description:
  Putative transcriptional regulator, GntR family; PFAM: aminotransferase class I and II; KEGG: eca:ECA4336 putative aminotransferase.


ensembl_gene_id: Spro_0234
symbol: Spro_0234
gene_biotype: protein_coding
description:
  PFAM: extracellular solute-binding protein family 1; KEGG: yen:YE0241 glycerol-3-phosphate-binding periplasmic protein.


ensembl_gene_id: Spro_0235
symbol: Spro_0235
gene_biotype: protein_coding
description:
  PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: yen:YE0242 sn-glycerol-3-phosphate transport system, permease protein.


ensembl_gene_id: Spro_0236
symbol: ugpE
gene_biotype: protein_coding
description:
  Binding-protein-dependent transport systems inner membrane component; Part of the binding-protein-dependent transport system for sn-glycerol-3-phosphate; probably responsible for the translocation of the substrate across the membrane.


ensembl_gene_id: Spro_0237
symbol: ugpC
gene_biotype: protein_coding
description:
  ABC transporter-related protein; Part of the ABC transporter complex UgpABCE involved in sn- glycerol-3-phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. sn-glycerol-3- phosphate importer (TC 3.A.1.1.3) family.


ensembl_gene_id: Spro_0238
symbol: Spro_0238
gene_biotype: protein_coding
description:
  PFAM: glycerophosphoryl diester phosphodiesterase; KEGG: ypp:YPDSF_3409 glycerophosphoryl diester phosphodiesterase.


ensembl_gene_id: Spro_0240
symbol: Spro_0240
gene_biotype: protein_coding
description:
  TIGRFAM: carboxylate/amino acid/amine transporter; PFAM: protein of unknown function DUF6 transmembrane; KEGG: ypp:YPDSF_3407 membrane protein.


ensembl_gene_id: Spro_0241
symbol: Spro_0241
gene_biotype: protein_coding
description:
  Transcriptional regulator, LysR family; PFAM: regulatory protein LysR; LysR substrate-binding; KEGG: ypi:YpsIP31758_0262 transcriptional regulator MetR.


ensembl_gene_id: Spro_0242
symbol: metE
gene_biotype: protein_coding
description:
  5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.


ensembl_gene_id: Spro_0243
symbol: Spro_0243
gene_biotype: protein_coding
description:
  Carboxymethylenebutenolidase; PFAM: dienelactone hydrolase; KEGG: ypi:YpsIP31758_0265 dienelactone hydrolase family protein.


ensembl_gene_id: Spro_0244
symbol: Spro_0244
gene_biotype: protein_coding
description:
  Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the PNP/UDP phosphorylase family.


ensembl_gene_id: Spro_0248
symbol: ubiE
gene_biotype: protein_coding
description:
  Ubiquinone/menaquinone biosynthesis methyltransferase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2).


ensembl_gene_id: Spro_0250
symbol: ubiB
gene_biotype: protein_coding
description:
  2-polyprenylphenol 6-hydroxylase; Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis.


ensembl_gene_id: Spro_0251
symbol: tatA
gene_biotype: protein_coding
description:
  Twin-arginine translocation protein, TatA/E family subunit; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.


ensembl_gene_id: Spro_0252
symbol: tatB
gene_biotype: protein_coding
description:
  Twin-arginine translocation protein, TatB subunit; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.


ensembl_gene_id: Spro_0253
symbol: tatC
gene_biotype: protein_coding
description:
  Sec-independent protein translocase, TatC subunit; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.


ensembl_gene_id: Spro_0254
symbol: tatD
gene_biotype: protein_coding
description:
  TatD-related deoxyribonuclease; 3'-5' exonuclease that prefers single-stranded DNA and RNA. May play a role in the H(2)O(2)-induced DNA damage repair. Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family. TatD subfamily.


ensembl_gene_id: Spro_0255
symbol: Spro_0255
gene_biotype: protein_coding
description:
  Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: yen:YE0263 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.


ensembl_gene_id: Spro_0256
symbol: rfaH
gene_biotype: protein_coding
description:
  Transcriptional acivator RfaH; Enhances distal genes transcription elongation in a specialized subset of operons that encode extracytoplasmic components. RfaH is recruited into a multi-component RNA polymerase complex by the ops element, which is a short conserved DNA sequence located downstream of the main promoter of these operons. Once bound, RfaH suppresses pausing and inhibits Rho-dependent and intrinsic termination at a subset of sites. Termination signals are bypassed, which allows complete synthesis of long RNA chains.


ensembl_gene_id: Spro_0257
symbol: Spro_0257
gene_biotype: protein_coding
description:
  PFAM: peptidase S51 dipeptidase E; KEGG: aha:AHA_3293 dipeptidase E; Belongs to the peptidase S51 family.


ensembl_gene_id: Spro_0258
symbol: ubiD
gene_biotype: protein_coding
description:
  UbiD family decarboxylase; Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis.


ensembl_gene_id: Spro_0259
symbol: Spro_0259
gene_biotype: protein_coding
description:
  PFAM: oxidoreductase FAD/NAD(P)-binding domain protein; Oxidoreductase FAD-binding domain protein; KEGG: ypi:YpsIP31758_0281 NAD(P)H-flavin reductase.


ensembl_gene_id: Spro_0260
symbol: fadA
gene_biotype: protein_coding
description:
  acetyl-CoA C-acyltransferase FadA; Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.


ensembl_gene_id: Spro_0261
symbol: fadB
gene_biotype: protein_coding
description:
  Fatty oxidation complex, alpha subunit FadB; Involved in the aerobic and anaerobic degradation of long- chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate. In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.


ensembl_gene_id: Spro_0264
symbol: Spro_0264
gene_biotype: protein_coding
description:
  PFAM: protein of unknown function UPF0029; Domain of unknown function DUF1949; KEGG: ypi:YpsIP31758_0285 hypothetical protein.


ensembl_gene_id: Spro_0265
symbol: Spro_0265
gene_biotype: protein_coding
description:
  Potassium uptake protein, TrkH family; Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA; Belongs to the TrkH potassium transport family.


ensembl_gene_id: Spro_0268
symbol: birA
gene_biotype: protein_coding
description:
  Bifunctional BirA, biotin operon repressor/biotin--acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon.


ensembl_gene_id: Spro_0269
symbol: coaA
gene_biotype: protein_coding
description:
  KEGG: ypi:YpsIP31758_3870 pantothenate kinase; TIGRFAM: pantothenate kinase; PFAM: phosphoribulokinase/uridine kinase.


ensembl_gene_id: Spro_0270
symbol: tuf1
gene_biotype: protein_coding
description:
  Translation elongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis.


ensembl_gene_id: Spro_0271
symbol: secE
gene_biotype: protein_coding
description:
  Preprotein translocase, SecE subunit; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation; Belongs to the SecE/SEC61-gamma family.


ensembl_gene_id: Spro_0272
symbol: nusG
gene_biotype: protein_coding
description:
  NusG antitermination factor; Participates in transcription elongation, termination and antitermination. In the absence of Rho, increases the rate of transcription elongation by the RNA polymerase (RNAP), probably by partially suppressing pausing. In the presence of Rho, modulates most Rho-dependent termination events by interacting with the RNAP to render the complex more susceptible to the termination activity of Rho. May be required to overcome a kinetic limitation of Rho to function at certain terminators. Also involved in ribosomal RNA transcriptional antitermination; Belongs to th [...]


ensembl_gene_id: Spro_0273
symbol: rplK
gene_biotype: protein_coding
description:
  Ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.


ensembl_gene_id: Spro_0274
symbol: rplA
gene_biotype: protein_coding
description:
  Ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.


ensembl_gene_id: Spro_0275
symbol: rplJ
gene_biotype: protein_coding
description:
  Ribosomal protein L10; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family.


ensembl_gene_id: Spro_0276
symbol: rplL
gene_biotype: protein_coding
description:
  Ribosomal protein L7/L12; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family.


ensembl_gene_id: Spro_0277
symbol: rpoB
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.


ensembl_gene_id: Spro_0278
symbol: rpoC
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerase, beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.


ensembl_gene_id: Spro_0279
symbol: Spro_0279
gene_biotype: protein_coding
description:
  TIGRFAM: thiazole biosynthesis protein ThiH; PFAM: Radical SAM domain protein; biotin and thiamin synthesis associated; KEGG: ypi:YpsIP31758_3857 thiazole biosynthesis protein ThiH.


ensembl_gene_id: Spro_0280
symbol: thiG
gene_biotype: protein_coding
description:
  Thiazole biosynthesis family protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.


ensembl_gene_id: Spro_0281
symbol: Spro_0281
gene_biotype: protein_coding
description:
  TIGRFAM: thiamine biosynthesis protein ThiS; PFAM: thiamineS protein; KEGG: plu:plu0483 thiS protein.


ensembl_gene_id: Spro_0282
symbol: Spro_0282
gene_biotype: protein_coding
description:
  PFAM: UBA/THIF-type NAD/FAD binding protein; MoeZ/MoeB domain protein; KEGG: eca:ECA0230 thiamine biosynthesis adenylyltransferase.


ensembl_gene_id: Spro_0283
symbol: thiE
gene_biotype: protein_coding
description:
  Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.


ensembl_gene_id: Spro_0284
symbol: thiC
gene_biotype: protein_coding
description:
  Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.


ensembl_gene_id: Spro_0285
symbol: rsd
gene_biotype: protein_coding
description:
  Regulator of RpoD, Rsd/AlgQ; Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase.


ensembl_gene_id: Spro_0286
symbol: nudC
gene_biotype: protein_coding
description:
  NAD(+) diphosphatase; PFAM: NUDIX hydrolase; NADH pyrophosphatase-like; Zinc ribbon NADH pyrophosphatase; KEGG: yen:YE0296 hypothetical protein; Belongs to the Nudix hydrolase family. NudC subfamily.


ensembl_gene_id: Spro_0287
symbol: hemE
gene_biotype: protein_coding
description:
  Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.


ensembl_gene_id: Spro_0288
symbol: nfi
gene_biotype: protein_coding
description:
  Deoxyribonuclease V; DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.


ensembl_gene_id: Spro_0290
symbol: Spro_0290
gene_biotype: protein_coding
description:
  Histone family protein DNA-binding protein; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.


ensembl_gene_id: Spro_0292
symbol: purD
gene_biotype: protein_coding
description:
  KEGG: yps:YPTB0299 phosphoribosylamine--glycine ligase; TIGRFAM: phosphoribosylamine--glycine ligase; PFAM: phosphoribosylglycinamide synthetase; protein of unknown function DUF201; Belongs to the GARS family.


ensembl_gene_id: Spro_0293
symbol: purH
gene_biotype: protein_coding
description:
  KEGG: yps:YPTB0300 phosphoribosylaminoimidazolecarboxamide formyltransferase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region.


ensembl_gene_id: Spro_0294
symbol: Spro_0294
gene_biotype: protein_coding
description:
  PFAM: coagulation factor 5/8 type domain protein; type I phosphodiesterase/nucleotide pyrophosphatase; KEGG: fno:Fnod_0251 hypothetical protein.


ensembl_gene_id: Spro_0295
symbol: actP
gene_biotype: protein_coding
description:
  Cation/acetate symporter ActP; Transports acetate; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.


ensembl_gene_id: Spro_0297
symbol: acs
gene_biotype: protein_coding
description:
  acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. Acs undergoes a two-step reaction. In the first half reaction, Acs combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.


ensembl_gene_id: Spro_0298
symbol: gltP
gene_biotype: protein_coding
description:
  Sodium:dicarboxylate symporter; Catalyzes the proton-dependent transport of glutamate and aspartate; Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. GltP subfamily.


ensembl_gene_id: Spro_0299
symbol: Spro_0299
gene_biotype: protein_coding
description:
  Peptidase M23B; PFAM: Peptidoglycan-binding LysM; peptidase M23B; KEGG: yen:YE2451 putative lipoprotein.


ensembl_gene_id: Spro_0302
symbol: Spro_0302
gene_biotype: protein_coding
description:
  Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily.


ensembl_gene_id: Spro_0310
symbol: Spro_0310
gene_biotype: protein_coding
description:
  DNA topoisomerase III; KEGG: plu:plu1037 unnamed protein product; similar to DNA topoisomerase III; TIGRFAM: DNA topoisomerase III; PFAM: TOPRIM domain protein; DNA topoisomerase type IA central domain protein; DNA topoisomerase type IA zn finger domain protein; SMART: DNA topoisomerase I ATP-binding; DNA topoisomerase I DNA-binding; Toprim sub domain protein.


ensembl_gene_id: Spro_0312
symbol: Spro_0312
gene_biotype: protein_coding
description:
  Single-strand binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.


ensembl_gene_id: Spro_0339
symbol: Spro_0339
gene_biotype: protein_coding
description:
  PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: pst:PSPTO_2960 pyridoxal-phosphate dependent enzyme family/ornithine cyclodeaminase family protein.


ensembl_gene_id: Spro_0340
symbol: Spro_0340
gene_biotype: protein_coding
description:
  PFAM: ornithine cyclodeaminase/mu-crystallin; KEGG: vei:Veis_1206 ornithine cyclodeaminase/mu-crystallin.


ensembl_gene_id: Spro_0342
symbol: Spro_0342
gene_biotype: protein_coding
description:
  TIGRFAM: amino acid adenylation domain; PFAM: AMP-dependent synthetase and ligase; phosphopantetheine-binding; KEGG: bce:BC2456 peptide synthetase.


ensembl_gene_id: Spro_0346
symbol: Spro_0346
gene_biotype: protein_coding
description:
  TIGRFAM: asparagine synthase (glutamine-hydrolyzing); PFAM: glutamine amidotransferase class-II; asparagine synthase; KEGG: sus:Acid_4624 asparagine synthase (glutamine-hydrolyzing).


ensembl_gene_id: Spro_0357
symbol: Spro_0357
gene_biotype: protein_coding
description:
  PFAM: IstB domain protein ATP-binding protein; SMART: AAA ATPase; KEGG: pst:PSPTO_B0039 transposase/IS protein.


ensembl_gene_id: Spro_0365
symbol: Spro_0365
gene_biotype: protein_coding
description:
  TIGRFAM: integral membrane protein, PqiA family; PFAM: Paraquat-inducible protein A; KEGG: ypi:YpsIP31758_2550 paraquat-inducible protein A.


ensembl_gene_id: Spro_0366
symbol: Spro_0366
gene_biotype: protein_coding
description:
  PFAM: Mammalian cell entry related domain protein; KEGG: yen:YE1574 putative paraquat-inducible protein B.


ensembl_gene_id: Spro_0398
symbol: Spro_0398
gene_biotype: protein_coding
description:
  PFAM: short-chain dehydrogenase/reductase SDR; KR domain protein; KEGG: ypi:YpsIP31758_2523 oxidoreductase, short chain dehydrogenase/reductase family protein.


ensembl_gene_id: Spro_0399
symbol: Spro_0399
gene_biotype: protein_coding
description:
  Transcriptional regulator, LuxR family; PFAM: regulatory protein LuxR; KEGG: asa:ASA_P5G023 hypothetical protein.


ensembl_gene_id: Spro_0400
symbol: Spro_0400
gene_biotype: protein_coding
description:
  Relaxase; PFAM: protein of unknown function DUF1528; Relaxase; KEGG: eca:ECA0613 hypothetical protein.


ensembl_gene_id: Spro_0401
symbol: Spro_0401
gene_biotype: protein_coding
description:
  PFAM: integrase family protein; KEGG: plu:plu1166 hypothetical protein; Belongs to the 'phage' integrase family.


ensembl_gene_id: Spro_0402
symbol: Spro_0402
gene_biotype: protein_coding
description:
  Transcriptional regulator, TetR family; PFAM: regulatory protein TetR; KEGG: ypk:y0598 hypothetical protein.


ensembl_gene_id: Spro_0403
symbol: dsbD
gene_biotype: protein_coding
description:
  Protein-disulfide reductase; Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps. Belongs to the thioredoxin family. DsbD subfamily.


ensembl_gene_id: Spro_0404
symbol: cutA
gene_biotype: protein_coding
description:
  CutA1 divalent ion tolerance protein; Involved in resistance toward heavy metals. Belongs to the CutA family.


ensembl_gene_id: Spro_0405
symbol: Spro_0405
gene_biotype: protein_coding
description:
  Anaerobic c4-dicarboxylate antiporter, Dcu family; Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane; Belongs to the DcuA/DcuB transporter (TC 2.A.13.1) family.


ensembl_gene_id: Spro_0408
symbol: groS
gene_biotype: protein_coding
description:
  Chaperonin Cpn10; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.


ensembl_gene_id: Spro_0409
symbol: groL
gene_biotype: protein_coding
description:
  Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.


ensembl_gene_id: Spro_0411
symbol: Spro_0411
gene_biotype: protein_coding
description:
  KEGG: yen:YE0356 hypothetical protein; TIGRFAM: lysine 2,3-aminomutase YodO family protein; PFAM: Radical SAM domain protein.


ensembl_gene_id: Spro_0412
symbol: efp
gene_biotype: protein_coding
description:
  Translation elongation factor P; Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation; Belongs to the elongation factor P family.


ensembl_gene_id: Spro_0415
symbol: Spro_0415
gene_biotype: protein_coding
description:
  PFAM: small multidrug resistance protein; KEGG: stm:STM4338 putative DMT superfamily transport protein.


ensembl_gene_id: Spro_0416
symbol: frdD
gene_biotype: protein_coding
description:
  Fumarate reductase D subunit; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane.


ensembl_gene_id: Spro_0417
symbol: frdC
gene_biotype: protein_coding
description:
  Fumarate reductase subunit C; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane.


ensembl_gene_id: Spro_0418
symbol: Spro_0418
gene_biotype: protein_coding
description:
  KEGG: yen:YE0363 fumarate reductase iron-sulfur protein; TIGRFAM: succinate dehydrogenase and fumarate reductase iron-sulfur protein; PFAM: ferredoxin; 4Fe-4S ferredoxin iron-sulfur binding domain protein; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.


ensembl_gene_id: Spro_0419
symbol: Spro_0419
gene_biotype: protein_coding
description:
  KEGG: ypi:YpsIP31758_3667 fumarate reductase, flavoprotein subunit; TIGRFAM: fumarate reductase, flavoprotein subunit; succinate dehydrogenase or fumarate reductase, flavoprotein subunit; PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; FAD-dependent pyridine nucleotide-disulphide oxidoreductase.


ensembl_gene_id: Spro_0420
symbol: epmA
gene_biotype: protein_coding
description:
  lysyl-tRNA synthetase-related protein GenX; With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF- P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta-lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P; Belongs to the class-II aminoacyl-tRNA synthetase family. EpmA subfamily.


ensembl_gene_id: Spro_0421
symbol: Spro_0421
gene_biotype: protein_coding
description:
  PFAM: MscS Mechanosensitive ion channel; KEGG: ypi:YpsIP31758_3664 mechanosensitive ion channel domain protein.


ensembl_gene_id: Spro_0422
symbol: psd
gene_biotype: protein_coding
description:
  Phosphatidylserine decarboxylase; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).


ensembl_gene_id: Spro_0423
symbol: rsgA
gene_biotype: protein_coding
description:
  Ribosome small subunit-dependent GTPase A; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.


ensembl_gene_id: Spro_0424
symbol: orn
gene_biotype: protein_coding
description:
  Exonuclease RNase T and DNA polymerase III; 3'-to-5' exoribonuclease specific for small oligoribonucleotides; Belongs to the oligoribonuclease family.


ensembl_gene_id: Spro_0425
symbol: queG
gene_biotype: protein_coding
description:
  Putative iron-sulfur cluster binding protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr); Belongs to the QueG family.


ensembl_gene_id: Spro_0426
symbol: nnrD
gene_biotype: protein_coding
description:
  Carbohydrate kinase, YjeF related protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. In the C-terminal section; belongs to the NnrD/CARKD family.


ensembl_gene_id: Spro_0428
symbol: Spro_0428
gene_biotype: protein_coding
description:
  N-acetylmuramoyl-L-alanine amidase; PFAM: Peptidoglycan-binding LysM; cell wall hydrolase/autolysin; KEGG: yen:YE0374 putative N-acetylmuramoyl-L-alanine amidase-family protein.


ensembl_gene_id: Spro_0429
symbol: mutL
gene_biotype: protein_coding
description:
  DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.


ensembl_gene_id: Spro_0430
symbol: miaA
gene_biotype: protein_coding
description:
  tRNA delta(2)-isopentenylpyrophosphate transferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family.


ensembl_gene_id: Spro_0431
symbol: hfq
gene_biotype: protein_coding
description:
  RNA chaperone Hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family.


ensembl_gene_id: Spro_0432
symbol: hflX
gene_biotype: protein_coding
description:
  GTP-binding protein HSR1-related; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.


ensembl_gene_id: Spro_0436
symbol: purA
gene_biotype: protein_coding
description:
  Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.


ensembl_gene_id: Spro_0437
symbol: nsrR
gene_biotype: protein_coding
description:
  Transcriptional regulator, BadM/Rrf2 family; Nitric oxide-sensitive repressor of genes involved in protecting the cell against nitrosative stress. May require iron for activity.


ensembl_gene_id: Spro_0438
symbol: rnr
gene_biotype: protein_coding
description:
  Ribonuclease R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. Belongs to the RNR ribonuclease family. RNase R subfamily.


ensembl_gene_id: Spro_0439
symbol: rlmB
gene_biotype: protein_coding
description:
  RNA methyltransferase, TrmH family, group 3; Specifically methylates the ribose of guanosine 2251 in 23S rRNA; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. RlmB subfamily.


ensembl_gene_id: Spro_0440
symbol: Spro_0440
gene_biotype: protein_coding
description:
  PFAM: acyl-CoA dehydrogenase domain protein; Acyl-CoA dehydrogenase type 2 domain; KEGG: yps:YPTB0434 putative acyl-CoA dehydrogenase.


ensembl_gene_id: Spro_0442
symbol: Spro_0442
gene_biotype: protein_coding
description:
  PFAM: protein of unknown function DUF1471; KEGG: ent:Ent638_0367 protein of unknown function DUF1471.


ensembl_gene_id: Spro_0444
symbol: Spro_0444
gene_biotype: protein_coding
description:
  PFAM: phospholipase/Carboxylesterase; KEGG: ypi:YpsIP31758_3640 phospholipase/carboxylesterase family protein.


ensembl_gene_id: Spro_0447
symbol: priB
gene_biotype: protein_coding
description:
  Single-strand binding protein/Primosomal replication protein n; Binds single-stranded DNA at the primosome assembly site (PAS); Belongs to the PriB family.


ensembl_gene_id: Spro_0448
symbol: rpsR
gene_biotype: protein_coding
description:
  Ribosomal protein S18; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family.


ensembl_gene_id: Spro_0451
symbol: Spro_0451
gene_biotype: protein_coding
description:
  PFAM: Opacity-associated protein A; Opacity-associated protein A domain protein; KEGG: yen:YE0397 hypothetical protein.


ensembl_gene_id: Spro_0452
symbol: Spro_0452
gene_biotype: protein_coding
description:
  PFAM: peptidylprolyl isomerase FKBP-type; KEGG: eca:ECA3607 FkbP-type peptidyl-prolyl cis-trans isomerase.


ensembl_gene_id: Spro_0453
symbol: Spro_0453
gene_biotype: protein_coding
description:
  TIGRFAM: 2',3'-cyclic-nucleotide 2'-phosphodiesterase; PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: yen:YE0399 2',3'-cyclic-nucleotide 2'-phosphodiesterase precursor; Belongs to the 5'-nucleotidase family.


ensembl_gene_id: Spro_0454
symbol: cysQ
gene_biotype: protein_coding
description:
  3'(2'),5'-bisphosphate nucleotidase; Converts adenosine-3',5'-bisphosphate (PAP) to AMP. Belongs to the inositol monophosphatase superfamily. CysQ family.


ensembl_gene_id: Spro_0456
symbol: Spro_0456
gene_biotype: protein_coding
description:
  PFAM: protein of unknown function DUF1107; KEGG: ent:Ent638_0395 protein of unknown function DUF1107.


ensembl_gene_id: Spro_0457
symbol: Spro_0457
gene_biotype: protein_coding
description:
  PFAM: CBS domain containing protein; protein of unknown function DUF21; transporter-associated region; KEGG: ypi:YpsIP31758_3627 CBS/transporter associated domain protein.


ensembl_gene_id: Spro_0458
symbol: msrA
gene_biotype: protein_coding
description:
  Peptide methionine sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.


ensembl_gene_id: Spro_0459
symbol: Spro_0459
gene_biotype: protein_coding
description:
  PFAM: surface antigen (D15); surface antigen variable number repeat protein; KEGG: ypi:YpsIP31758_3625 surface antigen/outer membrane protein, OMP85 family.


ensembl_gene_id: Spro_0462
symbol: ppa
gene_biotype: protein_coding
description:
  Inorganic diphosphatase; Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.


ensembl_gene_id: Spro_0463
symbol: Spro_0463
gene_biotype: protein_coding
description:
  PFAM: histidine kinase HAMP region domain protein; chemotaxis sensory transducer; KEGG: yen:YE0409 methyl-accepting chemotaxis protein.


ensembl_gene_id: Spro_0464
symbol: fbp
gene_biotype: protein_coding
description:
  PFAM: Inositol phosphatase/fructose-16-bisphosphatase; KEGG: ypi:YpsIP31758_3621 fructose-1,6-bisphosphatase.


ensembl_gene_id: Spro_0465
symbol: mpl
gene_biotype: protein_coding
description:
  UDP-N-acetylmuramate; Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl- meso-diaminopimelate by linking it to UDP-N-acetylmuramate. Belongs to the MurCDEF family. Mpl subfamily.


ensembl_gene_id: Spro_0470
symbol: Spro_0470
gene_biotype: protein_coding
description:
  Putative transcriptional regulator, Nlp; KEGG: ypi:YpsIP31758_3615 sugar fermentation stimulation protein B.


ensembl_gene_id: Spro_0472
symbol: Spro_0472
gene_biotype: protein_coding
description:
  PFAM: Polyprenyl synthetase; KEGG: eca:ECA0689 octaprenyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family.


ensembl_gene_id: Spro_0473
symbol: rplU
gene_biotype: protein_coding
description:
  Ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family.


ensembl_gene_id: Spro_0474
symbol: rpmA
gene_biotype: protein_coding
description:
  PFAM: ribosomal protein L27; KEGG: yen:YE0419 50S ribosomal protein L27; Belongs to the bacterial ribosomal protein bL27 family.


ensembl_gene_id: Spro_0475
symbol: Spro_0475
gene_biotype: protein_coding
description:
  PFAM: protein of unknown function DUF6 transmembrane; KEGG: ypi:YpsIP31758_3610 integral membrane protein.


ensembl_gene_id: Spro_0476
symbol: obg
gene_biotype: protein_coding
description:
  GTP-binding protein Obg/CgtA; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.


ensembl_gene_id: Spro_0477
symbol: Spro_0477
gene_biotype: protein_coding
description:
  Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; KEGG: yen:YE0422 two-component system sensor protein.


ensembl_gene_id: Spro_0478
symbol: Spro_0478
gene_biotype: protein_coding
description:
  Two component transcriptional regulator, winged helix family; PFAM: response regulator receiver; transcriptional regulator domain protein; KEGG: ypi:YpsIP31758_3607 transcriptional regulatory protein BasR/PmrA.


ensembl_gene_id: Spro_0479
symbol: Spro_0479
gene_biotype: protein_coding
description:
  KEGG: yen:YE0424 penicillin-binding protein 4 precursor; TIGRFAM: D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase; PFAM: peptidase S13 D-Ala-D-Ala carboxypeptidase C.


ensembl_gene_id: Spro_0480
symbol: greA
gene_biotype: protein_coding
description:
  Transcription elongation factor GreA; Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.


ensembl_gene_id: Spro_0482
symbol: rlmE
gene_biotype: protein_coding
description:
  Ribosomal RNA large subunit methyltransferase J; Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.


ensembl_gene_id: Spro_0483
symbol: ftsH
gene_biotype: protein_coding
description:
  ATP-dependent metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family.  In the central section; belongs to the AAA ATPase family.


ensembl_gene_id: Spro_0484
symbol: Spro_0484
gene_biotype: protein_coding
description:
  Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives.


ensembl_gene_id: Spro_0485
symbol: glmM
gene_biotype: protein_coding
description:
  Phosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family.


ensembl_gene_id: Spro_0486
symbol: Spro_0486
gene_biotype: protein_coding
description:
  Preprotein translocase, SecG subunit; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family.


ensembl_gene_id: Spro_0487
symbol: rimP
gene_biotype: protein_coding
description:
  Protein of unknown function DUF150; Required for maturation of 30S ribosomal subunits. Belongs to the RimP family.


ensembl_gene_id: Spro_0489
symbol: infB
gene_biotype: protein_coding
description:
  Translation initiation factor IF-2; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.


ensembl_gene_id: Spro_0490
symbol: rbfA
gene_biotype: protein_coding
description:
  Ribosome-binding factor A; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.


ensembl_gene_id: Spro_0491
symbol: truB
gene_biotype: protein_coding
description:
  tRNA pseudouridine synthase B; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.


ensembl_gene_id: Spro_0492
symbol: rpsO
gene_biotype: protein_coding
description:
  Ribosomal protein S15; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.


ensembl_gene_id: Spro_0493
symbol: pnp
gene_biotype: protein_coding
description:
  Polyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction.


ensembl_gene_id: Spro_0495
symbol: deaD
gene_biotype: protein_coding
description:
  DEAD/DEAH box helicase domain protein; DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation.


ensembl_gene_id: Spro_0496
symbol: Spro_0496
gene_biotype: protein_coding
description:
  PFAM: protein of unknown function DUF395 YeeE/YedE; KEGG: ypi:YpsIP31758_3810 YeeE/YedE family protein.


ensembl_gene_id: Spro_0497
symbol: Spro_0497
gene_biotype: protein_coding
description:
  PFAM: SirA family protein; KEGG: net:Neut_1003 SirA family protein; Belongs to the sulfur carrier protein TusA family.


ensembl_gene_id: Spro_0499
symbol: Spro_0499
gene_biotype: protein_coding
description:
  PFAM: secretion protein HlyD family protein; KEGG: plu:plu4516 unnamed protein product; highly similar to membrane fusion protein (MFP) of ABC transport system.


ensembl_gene_id: Spro_0500
symbol: Spro_0500
gene_biotype: protein_coding
description:
  PFAM: ABC-2 type transporter; KEGG: plu:plu4515 unnamed protein product; similar to permease protein of ABC transport system.


ensembl_gene_id: Spro_0501
symbol: Spro_0501
gene_biotype: protein_coding
description:
  PFAM: ABC-2 type transporter; KEGG: plu:plu4514 unnamed protein product; similar to permease protein of ABC transport system.


ensembl_gene_id: Spro_0502
symbol: Spro_0502
gene_biotype: protein_coding
description:
  PFAM: Cupin 4 family protein; SMART: transcription factor jumonji jmjC domain protein; KEGG: ent:Ent638_0491 cupin 4 family protein.


ensembl_gene_id: Spro_0507
symbol: Spro_0507
gene_biotype: protein_coding
description:
  PFAM: Excinuclease ABC C subunit domain protein; KEGG: yen:YE0453 hypothetical protein; Belongs to the UPF0213 family.


ensembl_gene_id: Spro_0508
symbol: potE
gene_biotype: protein_coding
description:
  Amino acid permease-associated region; Catalyzes both the uptake and excretion of putrescine. The uptake of putrescine is dependent on the membrane potential and the excretion involves putrescine-ornithine antiporter activity. Belongs to the amino acid-polyamine-organocation (APC) superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2) family.


ensembl_gene_id: Spro_0509
symbol: Spro_0509
gene_biotype: protein_coding
description:
  PFAM: Orn/Lys/Arg decarboxylase major region; Orn/Lys/Arg decarboxylase domain protein; KEGG: yen:YE0455 ornithine decarboxylase, inducible.


ensembl_gene_id: Spro_0514
symbol: phnN
gene_biotype: protein_coding
description:
  Phosphonate metabolism protein/1,5-bisphosphokinase (PRPP-forming) PhnN; Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP).


ensembl_gene_id: Spro_0515
symbol: Spro_0515
gene_biotype: protein_coding
description:
  TIGRFAM: phosphonate metabolism protein PhnM; PFAM: amidohydrolase; Amidohydrolase 3; KEGG: ypn:YPN_0624 PhnM protein.


ensembl_gene_id: Spro_0516
symbol: Spro_0516
gene_biotype: protein_coding
description:
  Phosphonate C-P lyase system protein PhnL; KEGG: ypp:YPDSF_3272 phosphonates transport ATP-binding protein; TIGRFAM: phosphonate C-P lyase system protein PhnL; PFAM: ABC transporter related; SMART: AAA ATPase.


ensembl_gene_id: Spro_0517
symbol: Spro_0517
gene_biotype: protein_coding
description:
  Phosphonate C-P lyase system protein PhnK; KEGG: yen:YE0473 phosphonates transport ATP-binding protein; TIGRFAM: phosphonate C-P lyase system protein PhnK; PFAM: ABC transporter related; SMART: AAA ATPase.


ensembl_gene_id: Spro_0518
symbol: Spro_0518
gene_biotype: protein_coding
description:
  Phosphonate metabolism PhnJ; Catalyzes the breakage of the C-P bond in alpha-D-ribose 1- methylphosphonate 5-phosphate (PRPn) forming alpha-D-ribose. Belongs to the PhnJ family.


ensembl_gene_id: Spro_0522
symbol: Spro_0522
gene_biotype: protein_coding
description:
  Transcriptional regulator, GntR family; TIGRFAM: phosphonates metabolism transcriptional regulator PhnF; PFAM: regulatory protein GntR HTH; UbiC transcription regulator-associated domain protein; KEGG: yen:YE0478 probable GntR-family transcriptional regulatory protein.


ensembl_gene_id: Spro_0524
symbol: Spro_0524
gene_biotype: protein_coding
description:
  Anaerobic ribonucleoside-triphosphate reductase activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.


ensembl_gene_id: Spro_0525
symbol: Spro_0525
gene_biotype: protein_coding
description:
  KEGG: yen:YE0482 anaerobic ribonucleoside-triphosphate reductase; TIGRFAM: anaerobic ribonucleoside-triphosphate reductase; PFAM: formate C-acetyltransferase glycine radical; ATP-cone domain protein.


ensembl_gene_id: Spro_0526
symbol: Spro_0526
gene_biotype: protein_coding
description:
  Transcriptional regulator, LysR family; PFAM: regulatory protein LysR; LysR substrate-binding; KEGG: yen:YE0483 putative LysR-family transcriptional regulatory protein.


ensembl_gene_id: Spro_0528
symbol: Spro_0528
gene_biotype: protein_coding
description:
  Alpha,alpha-phosphotrehalase; KEGG: yen:YE3773 putative trehalose-6-phosphate hydrolase; TIGRFAM: alpha,alpha-phosphotrehalase; PFAM: alpha amylase catalytic region; SMART: alpha amylase catalytic sub domain.


ensembl_gene_id: Spro_0529
symbol: Spro_0529
gene_biotype: protein_coding
description:
  TIGRFAM: PTS system, trehalose-specific IIBC subunit; PTS system, glucose-like IIB subunint; PFAM: phosphotransferase system PTS EIIB protein; phosphotransferase system EIIC; KEGG: yen:YE3774 PTS system, trehalose-specific IIBC component.


ensembl_gene_id: Spro_0534
symbol: Spro_0534
gene_biotype: protein_coding
description:
  Transcriptional regulator, LacI family; TIGRFAM: trehalose operon repressor; PFAM: regulatory protein LacI; periplasmic binding protein/LacI transcriptional regulator; KEGG: ypi:YpsIP31758_0432 trehalose operon repressor.


ensembl_gene_id: Spro_0535
symbol: Spro_0535
gene_biotype: protein_coding
description:
  KEGG: yen:YE3776 Mg2+ transporter ATPase; TIGRFAM: ATPase, P-type (transporting), HAD superfamily, subfamily IC; magnesium-translocating P-type ATPase; PFAM: cation transporting ATPase domain protein; Haloacid dehalogenase domain protein hydrolase; E1-E2 ATPase-associated domain protein.


ensembl_gene_id: Spro_0536
symbol: Spro_0536
gene_biotype: protein_coding
description:
  PFAM: Beta-N-acetylhexosaminidase-like; Glycoside hydrolase, family 20, catalytic core; KEGG: ent:Ent638_0442 beta-N-acetylhexosaminidase.


ensembl_gene_id: Spro_0538
symbol: Spro_0538
gene_biotype: protein_coding
description:
  PFAM: transglutaminase domain protein; transglutaminase domain protein; KEGG: yen:YE3771 hypothetical protein.


ensembl_gene_id: Spro_0540
symbol: Spro_0540
gene_biotype: protein_coding
description:
  PFAM: protein of unknown function DUF404; protein of unknown function DUF407; KEGG: yen:YE3769 hypothetical protein.


ensembl_gene_id: Spro_0543
symbol: Spro_0543
gene_biotype: protein_coding
description:
  TIGRFAM: putative endoribonuclease L-PSP; PFAM: Endoribonuclease L-PSP; KEGG: yen:YE3768 hypothetical protein.


ensembl_gene_id: Spro_0544
symbol: pyrI
gene_biotype: protein_coding
description:
  Aspartate carbamoyltransferase, regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase.


ensembl_gene_id: Spro_0545
symbol: pyrB
gene_biotype: protein_coding
description:
  KEGG: yen:YE3766 aspartate carbamoyltransferase catalytic subunit; TIGRFAM: aspartate carbamoyltransferase; PFAM: aspartate/ornithine carbamoyltransferase Asp/Orn-binding region; aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.


ensembl_gene_id: Spro_0546
symbol: Spro_0546
gene_biotype: protein_coding
description:
  PFAM: transport system permease protein; KEGG: eca:ECA4256 putative iron(III) ABC transporter permease protein; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.


ensembl_gene_id: Spro_0547
symbol: Spro_0547
gene_biotype: protein_coding
description:
  PFAM: periplasmic binding protein; KEGG: eca:ECA4255 putative iron(III) ABC transporter, periplasmic-binding protein.


ensembl_gene_id: Spro_0548
symbol: Spro_0548
gene_biotype: protein_coding
description:
  ABC transporter-related protein; PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: eca:ECA4254 putative iron(III) ABC transporter ATP-binding protein.


ensembl_gene_id: Spro_0550
symbol: Spro_0550
gene_biotype: protein_coding
description:
  Transcriptional regulator, RpiR family; PFAM: helix-turn-helix protein RpiR; sugar isomerase (SIS); KEGG: kpn:KPN_04798 putative transcriptional regulator (N-terminal); putative sugar-binding domain of regulator protein (C-terminal).


ensembl_gene_id: Spro_0551
symbol: Spro_0551
gene_biotype: protein_coding
description:
  N-acyl-D-amino-acid deacylase; PFAM: amidohydrolase; D-aminoacylase domain protein; Amidohydrolase 3; KEGG: kpn:KPN_04793 hypothetical protein.


ensembl_gene_id: Spro_0553
symbol: Spro_0553
gene_biotype: protein_coding
description:
  PFAM: extracellular solute-binding protein family 5; KEGG: yen:YE0491 ABC transporter, substrate binding protein.


ensembl_gene_id: Spro_0554
symbol: argI
gene_biotype: protein_coding
description:
  Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.


ensembl_gene_id: Spro_0555
symbol: rraB
gene_biotype: protein_coding
description:
  Protein of unknown function DUF1260; Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome.


ensembl_gene_id: Spro_0557
symbol: Spro_0557
gene_biotype: protein_coding
description:
  PFAM: glucose-methanol-choline oxidoreductase; GMC oxidoreductase; KEGG: bte:BTH_II0331 GMC oxidoreductase.


ensembl_gene_id: Spro_0560
symbol: valS
gene_biotype: protein_coding
description:
  valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.


ensembl_gene_id: Spro_0562
symbol: pepA
gene_biotype: protein_coding
description:
  Leucyl aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides.


ensembl_gene_id: Spro_0565
symbol: Spro_0565
gene_biotype: protein_coding
description:
  Filamentation induced by cAMP protein Fic; Adenylyltransferase that mediates the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins.


ensembl_gene_id: Spro_0566
symbol: Spro_0566
gene_biotype: protein_coding
description:
  Carbonate dehydratase; Reversible hydration of carbon dioxide. Belongs to the beta-class carbonic anhydrase family.


ensembl_gene_id: Spro_0567
symbol: Spro_0567
gene_biotype: protein_coding
description:
  Transcriptional regulator, XRE family; PFAM: helix-turn-helix domain protein; KEGG: ent:Ent638_2034 putative transcriptional regulator, XRE family.


ensembl_gene_id: Spro_0570
symbol: Spro_0570
gene_biotype: protein_coding
description:
  PFAM: ATP-binding region ATPase domain protein; KEGG: azo:azo0358 putative two-component sensor kinase.


ensembl_gene_id: Spro_0571
symbol: Spro_0571
gene_biotype: protein_coding
description:
  Type II site-specific deoxyribonuclease; PFAM: Restriction endonuclease EcoRII; KEGG: acr:Acry_3581 hypothetical protein.


ensembl_gene_id: Spro_0572
symbol: Spro_0572
gene_biotype: protein_coding
description:
  DNA mismatch endonuclease vsr; May nick specific sequences that contain T:G mispairs resulting from m5C-deamination.


ensembl_gene_id: Spro_0573
symbol: Spro_0573
gene_biotype: protein_coding
description:
  KEGG: plu:plu0338 DNA-cytosine methyltransferase; TIGRFAM: DNA-cytosine methyltransferase; PFAM: C-5 cytosine-specific DNA methylase.


ensembl_gene_id: Spro_0575
symbol: Spro_0575
gene_biotype: protein_coding
description:
  PFAM: glycoside hydrolase family 1; KEGG: sdy:SDY_2912 6-phospho-beta-glucosidase; Belongs to the glycosyl hydrolase 1 family.


ensembl_gene_id: Spro_0576
symbol: Spro_0576
gene_biotype: protein_coding
description:
  PFAM: phosphotransferase system PTS EIIB protein; phosphotransferase system EIIC; KEGG: yen:YE1256 PTS transport protein.


ensembl_gene_id: Spro_0577
symbol: Spro_0577
gene_biotype: protein_coding
description:
  Transcriptional regulator, LacI family; PFAM: regulatory protein LacI; periplasmic binding protein/LacI transcriptional regulator; KEGG: ent:Ent638_3187 regulatory protein, LacI.


ensembl_gene_id: Spro_0578
symbol: Spro_0578
gene_biotype: protein_coding
description:
  Transcriptional regulator, AraC family; PFAM: helix-turn-helix- domain containing protein AraC type; AraC protein arabinose-binding/dimerisation; KEGG: mmw:Mmwyl1_0262 transcriptional regulator, AraC family.


ensembl_gene_id: Spro_0579
symbol: Spro_0579
gene_biotype: protein_coding
description:
  TIGRFAM: drug resistance transporter, Bcr/CflA subfamily; PFAM: major facilitator superfamily MFS_1; KEGG: mmw:Mmwyl1_0263 drug resistance transporter, Bcr/CflA subfamily.


ensembl_gene_id: Spro_0580
symbol: Spro_0580
gene_biotype: protein_coding
description:
  PFAM: cobalamin synthesis protein P47K; cobalamin synthesis CobW domain protein; KEGG: eca:ECA1189 hypothetical protein.


ensembl_gene_id: Spro_0589
symbol: Spro_0589
gene_biotype: protein_coding
description:
  Transcriptional regulator, LysR family; PFAM: regulatory protein LysR; LysR substrate-binding; KEGG: kpn:KPN_02052 putative transcriptional regulator (LysR family).


ensembl_gene_id: Spro_0590
symbol: Spro_0590
gene_biotype: protein_coding
description:
  KEGG: pap:PSPA7_3295 probable CoA transferase, subunit A; TIGRFAM: 3-oxoacid CoA-transferase, A subunit; PFAM: coenzyme A transferase.


ensembl_gene_id: Spro_0591
symbol: Spro_0591
gene_biotype: protein_coding
description:
  KEGG: pap:PSPA7_3294 probable CoA transferase, subunit B; TIGRFAM: 3-oxoacid CoA-transferase, B subunit; PFAM: coenzyme A transferase.


ensembl_gene_id: Spro_0592
symbol: Spro_0592
gene_biotype: protein_coding
description:
  KEGG: ppu:PP_4636 beta-ketothiolase; TIGRFAM: acetyl-CoA acetyltransferase; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family.


ensembl_gene_id: Spro_0593
symbol: Spro_0593
gene_biotype: protein_coding
description:
  PFAM: 3-hydroxyacyl-CoA dehydrogenase domain protein; 3-hydroxyacyl-CoA dehydrogenase NAD-binding; KEGG: kpn:KPN_02056 3-hydroxybutyryl-CoA dehydrogenase.


ensembl_gene_id: Spro_0595
symbol: Spro_0595
gene_biotype: protein_coding
description:
  TIGRFAM: 3-hydroxybutyrate dehydrogenase; PFAM: short-chain dehydrogenase/reductase SDR; KEGG: kpn:KPN_02057 short chain dehydrogenase.


ensembl_gene_id: Spro_0596
symbol: Spro_0596
gene_biotype: protein_coding
description:
  Transcriptional regulator, AraC family; PFAM: helix-turn-helix- domain containing protein AraC type; KEGG: mmw:Mmwyl1_3814 helix-turn-helix-domain containing protein AraC type.


ensembl_gene_id: Spro_0597
symbol: Spro_0597
gene_biotype: protein_coding
description:
  Transcriptional regulator, AraC family; PFAM: helix-turn-helix- domain containing protein AraC type; transcription activator effector binding; KEGG: yen:YE0593 putative right origin-binding protein.


ensembl_gene_id: Spro_0602
symbol: Spro_0602
gene_biotype: protein_coding
description:
  PFAM: TonB-dependent receptor; TonB-dependent receptor plug; KEGG: eca:ECA0927 TonB-dependent receptor.


ensembl_gene_id: Spro_0606
symbol: Spro_0606
gene_biotype: protein_coding
description:
  TIGRFAM: methylmalonate-semialdehyde dehydrogenase; PFAM: aldehyde dehydrogenase; KEGG: aav:Aave_4746 methylmalonate-semialdehyde dehydrogenase.


ensembl_gene_id: Spro_0607
symbol: Spro_0607
gene_biotype: protein_coding
description:
  PFAM: aminotransferase class-III; KEGG: pna:Pnap_4039 aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.


ensembl_gene_id: Spro_0608
symbol: Spro_0608
gene_biotype: protein_coding
description:
  Transcriptional regulator, LysR family; PFAM: regulatory protein LysR; LysR substrate-binding; KEGG: rfr:Rfer_0374 transcriptional regulator, LysR family.


ensembl_gene_id: Spro_0611
symbol: Spro_0611
gene_biotype: protein_coding
description:
  PFAM: iron-containing alcohol dehydrogenase; KEGG: cte:CT0951 alcohol dehydrogenase, iron-containing.


ensembl_gene_id: Spro_0612
symbol: Spro_0612
gene_biotype: protein_coding
description:
  Transcriptional regulator, LuxR family; PFAM: regulatory protein LuxR; Sigma-70 region 4 type 2; KEGG: plu:plu4288 hypothetical protein.


ensembl_gene_id: Spro_0613
symbol: Spro_0613
gene_biotype: protein_coding
description:
  PFAM: FAD dependent oxidoreductase; KEGG: plu:plu4287 unnamed protein product; highly similar to probable oxidoreductase.


ensembl_gene_id: Spro_0618
symbol: Spro_0618
gene_biotype: protein_coding
description:
  Transcriptional regulator, LuxR family; PFAM: regulatory protein LuxR; KEGG: plu:plu4274 hypothetical protein.


ensembl_gene_id: Spro_0621
symbol: Spro_0621
gene_biotype: protein_coding
description:
  PFAM: short-chain dehydrogenase/reductase SDR; KR domain protein; KEGG: kpn:KPN_00526 putative 3-ketoacyl-(acyl-carrier-protein) reductase.


ensembl_gene_id: Spro_0623
symbol: Spro_0623
gene_biotype: protein_coding
description:
  PFAM: NAD-dependent epimerase/dehydratase; short-chain dehydrogenase/reductase SDR; KR domain protein; KEGG: bur:Bcep18194_B0903 short chain dehydrogenase.


ensembl_gene_id: Spro_0624
symbol: Spro_0624
gene_biotype: protein_coding
description:
  Transcriptional regulator, MarR family; TIGRFAM: homoprotocatechuate degradation operon regulator, HpaR; PFAM: regulatory protein MarR; KEGG: plu:plu0991 homoprotocatechuate degradation operon regulator.


ensembl_gene_id: Spro_0625
symbol: Spro_0625
gene_biotype: protein_coding
description:
  KEGG: plu:plu0990 hypothetical protein; TIGRFAM: 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, HpaG1 subunit; PFAM: fumarylacetoacetate (FAA) hydrolase.


ensembl_gene_id: Spro_0626
symbol: Spro_0626
gene_biotype: protein_coding
description:
  KEGG: plu:plu0989 similar to C-terminal region of 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase HpaG [includes: 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HHDD isomerase); 5-carboxymethyl-2-oxo-hex-3-ene-1,7-dioate decarboxylase (OPET decarboxylase)]; TIGRFAM: 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, HpaG2 subunit; PFAM: fumarylacetoacetate (FAA) hydrolase.


ensembl_gene_id: Spro_0627
symbol: Spro_0627
gene_biotype: protein_coding
description:
  TIGRFAM: 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; PFAM: aldehyde dehydrogenase; KEGG: kpn:KPN_04787 4-hydroxyphenylacetate catabolism; Belongs to the aldehyde dehydrogenase family.


ensembl_gene_id: Spro_0628
symbol: Spro_0628
gene_biotype: protein_coding
description:
  3,4-dihydroxyphenylacetate 2,3-dioxygenase; KEGG: kpn:KPN_04786 4-hydroxyphenylacetate catabolism; TIGRFAM: 3,4-dihydroxyphenylacetate 2,3-dioxygenase; PFAM: Extradiol ring-cleavage dioxygenase class III protein subunit B.


ensembl_gene_id: Spro_0629
symbol: Spro_0629
gene_biotype: protein_coding
description:
  PFAM: 5-carboxymethyl-2-hydroxymuconate isomerase; KEGG: plu:plu0986 5-carboxymethyl-2-hydroxy-muconic acid isomerase.


ensembl_gene_id: Spro_0630
symbol: Spro_0630
gene_biotype: protein_coding
description:
  2-oxo-hepta-3-ene-1,7-dioic acid hydratase; KEGG: ssn:SSON_4495 2-oxo-hept-3-ene-1,7-dioate hydratase; TIGRFAM: 2-oxo-hepta-3-ene-1,7-dioic acid hydratase; PFAM: Hydratase/decarboxylase.


ensembl_gene_id: Spro_0631
symbol: Spro_0631
gene_biotype: protein_coding
description:
  KEGG: ssn:SSON_4494 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase (HHED aldolase); TIGRFAM: 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; PFAM: HpcH/HpaI aldolase; Belongs to the HpcH/HpaI aldolase family.


ensembl_gene_id: Spro_0632
symbol: Spro_0632
gene_biotype: protein_coding
description:
  TIGRFAM: 4-hydroxyphenylacetate transporter; PFAM: major facilitator superfamily MFS_1; KEGG: sbo:SBO_4406 putative 4-hydroxyphenylacetate permease.


ensembl_gene_id: Spro_0633
symbol: Spro_0633
gene_biotype: protein_coding
description:
  Transcriptional regulator, AraC family; TIGRFAM: 4-hydroxyphenylacetate catabolism regulatory protein HpaA; PFAM: helix-turn-helix- domain containing protein AraC type; AraC protein arabinose-binding/dimerisation; KEGG: kpn:KPN_04781 4-hydroxyphenylacetate catabolism.


ensembl_gene_id: Spro_0634
symbol: Spro_0634
gene_biotype: protein_coding
description:
  TIGRFAM: 4-hydroxyphenylacetate 3-monooxygenase, oxygenase subunit; PFAM: 4-hydroxyphenylacetate 3-hydroxylase; KEGG: stm:STM1099 4-hydroxyphenylacetate catabolism.


ensembl_gene_id: Spro_0635
symbol: Spro_0635
gene_biotype: protein_coding
description:
  TIGRFAM: 4-hydroxyphenylacetate 3-monooxygenase, reductase subunit; PFAM: flavin reductase domain protein FMN-binding; KEGG: plu:plu0974 4-hydroxyphenylacetic acid hydroxylase.


ensembl_gene_id: Spro_0637
symbol: Spro_0637
gene_biotype: protein_coding
description:
  PFAM: regulatory protein GntR HTH; GntR domain protein; KEGG: bvi:Bcep1808_3378 GntR domain protein.


ensembl_gene_id: Spro_0638
symbol: Spro_0638
gene_biotype: protein_coding
description:
  PFAM: NAD-dependent epimerase/dehydratase; short-chain dehydrogenase/reductase SDR; KR domain protein; KEGG: ypi:YpsIP31758_2412 oxidoreductase, short chain dehydrogenase/reductase family protein.


ensembl_gene_id: Spro_0639
symbol: Spro_0639
gene_biotype: protein_coding
description:
  5-carboxymethyl-2-hydroxymuconate Delta-isomerase; PFAM: fumarylacetoacetate (FAA) hydrolase; KEGG: ypi:YpsIP31758_2411 fumarylacetoacetate hydrolase family protein.


ensembl_gene_id: Spro_0640
symbol: Spro_0640
gene_biotype: protein_coding
description:
  PFAM: Mandelate racemase/muconate lactonizing protein; KEGG: ypi:YpsIP31758_2410 mandelate racemase/muconate lactonizing enzyme family protein.


ensembl_gene_id: Spro_0642
symbol: Spro_0642
gene_biotype: protein_coding
description:
  PFAM: short-chain dehydrogenase/reductase SDR; KR domain protein; KEGG: bvi:Bcep1808_3383 short-chain dehydrogenase/reductase SDR.


ensembl_gene_id: Spro_0644
symbol: Spro_0644
gene_biotype: protein_coding
description:
  TIGRFAM: L-fucose transporter; PFAM: major facilitator superfamily MFS_1; KEGG: cff:CFF8240_1066 L-fucose:H+ symporter permease.


ensembl_gene_id: Spro_0647
symbol: Spro_0647
gene_biotype: protein_coding
description:
  Transcriptional regulator, LysR family; PFAM: regulatory protein LysR; LysR substrate-binding; KEGG: yen:YE0559 LysR-family regulatory protein; Belongs to the LysR transcriptional regulatory family.


ensembl_gene_id: Spro_0649
symbol: rsmC
gene_biotype: protein_coding
description:
  rRNA (guanine-N(2)-)-methyltransferase; Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle; Belongs to the methyltransferase superfamily. RsmC family.


ensembl_gene_id: Spro_0650
symbol: Spro_0650
gene_biotype: protein_coding
description:
  DNA polymerase III psi subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is unknown.


ensembl_gene_id: Spro_0651
symbol: Spro_0651
gene_biotype: protein_coding
description:
  Ribosomal-protein-alanine acetyltransferase; Acetylates the N-terminal alanine of ribosomal protein S18.


ensembl_gene_id: Spro_0652
symbol: prfC
gene_biotype: protein_coding
description:
  Peptide chain release factor 3; Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.


ensembl_gene_id: Spro_0653
symbol: Spro_0653
gene_biotype: protein_coding
description:
  PFAM: transport-associated; SMART: Transport-associated and nodulation region; KEGG: ypi:YpsIP31758_3503 osmotically induced periplasmic protein OsmY.


ensembl_gene_id: Spro_0654
symbol: Spro_0654
gene_biotype: protein_coding
description:
  PFAM: protein of unknown function DUF1328; KEGG: kpn:KPN_04833 putative amino acid/amine transport protein.


ensembl_gene_id: Spro_0658
symbol: Spro_0658
gene_biotype: protein_coding
description:
  PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: ecv:APECO1_2528 hypothetical protein; Belongs to the 5'-nucleotidase family.


ensembl_gene_id: Spro_0659
symbol: Spro_0659
gene_biotype: protein_coding
description:
  TIGRFAM: nucleoside transporter; PFAM: Na+ dependent nucleoside transporter; nucleoside recognition domain protein; Na+ dependent nucleoside transporter domain protein; KEGG: ypm:YP_3746 putative Na+ dependent nucleosidetransporter-family protein; Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.


ensembl_gene_id: Spro_0660
symbol: deoC
gene_biotype: protein_coding
description:
  Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily.


ensembl_gene_id: Spro_0661
symbol: deoA
gene_biotype: protein_coding
description:
  Thymidine phosphorylase; The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.


ensembl_gene_id: Spro_0662
symbol: deoB
gene_biotype: protein_coding
description:
  Phosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family.


ensembl_gene_id: Spro_0663
symbol: deoD
gene_biotype: protein_coding
description:
  TIGRFAM: purine nucleoside phosphorylase; PFAM: purine or other phosphorylase family 1; KEGG: yen:YE0574 purine nucleoside phosphorylase.


ensembl_gene_id: Spro_0666
symbol: Spro_0666
gene_biotype: protein_coding
description:
  KEGG: yen:YE0578 phosphoserine phosphatase; TIGRFAM: phosphoserine phosphatase SerB; HAD-superfamily hydrolase, subfamily IB (PSPase-like); PFAM: Haloacid dehalogenase domain protein hydrolase; Haloacid dehalogenase domain protein hydrolase type 3.


ensembl_gene_id: Spro_0667
symbol: radA
gene_biotype: protein_coding
description:
  DNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.


ensembl_gene_id: Spro_0668
symbol: Spro_0668
gene_biotype: protein_coding
description:
  Transcriptional regulator, XRE family; TIGRFAM: cytidyltransferase-related domain; nicotinamide-nucleotide adenylyltransferase; PFAM: helix-turn-helix domain protein; KEGG: yps:YPTB0588 transcriptional regulator NadR.


ensembl_gene_id: Spro_0669
symbol: Spro_0669
gene_biotype: protein_coding
description:
  TIGRFAM: Alcohol dehydrogenase. zinc-binding type 1; PFAM: Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KEGG: yen:YE0581 putative oxidoreductase; Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.


ensembl_gene_id: Spro_0670
symbol: Spro_0670
gene_biotype: protein_coding
description:
  Transcriptional regulator, LysR family; PFAM: regulatory protein LysR; LysR substrate-binding; KEGG: yen:YE0582 putative LysR-family transcriptional regulatory protein.


ensembl_gene_id: Spro_0671
symbol: Spro_0671
gene_biotype: protein_coding
description:
  ABC transporter-related protein; PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: eca:ECA3901 putative ABC transporter ATP-binding protein.


ensembl_gene_id: Spro_0673
symbol: Spro_0673
gene_biotype: protein_coding
description:
  TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; histidine kinase HAMP region domain protein; KEGG: yen:YE0586 hypothetical protein.


ensembl_gene_id: Spro_0675
symbol: Spro_0675
gene_biotype: protein_coding
description:
  PFAM: Lytic transglycosylase catalytic; KEGG: yen:YE0589 putative soluble lytic murein transglycosylase.


ensembl_gene_id: Spro_0676
symbol: trpR
gene_biotype: protein_coding
description:
  Trp operon repressor; This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region.


ensembl_gene_id: Spro_0677
symbol: Spro_0677
gene_biotype: protein_coding
description:
  Protein of unknown function DUF84; Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.


ensembl_gene_id: Spro_0678
symbol: gpmB
gene_biotype: protein_coding
description:
  PFAM: Phosphoglycerate mutase; KEGG: plu:plu0559 phosphoglyceromutase 2; Belongs to the phosphoglycerate mutase family. GpmB subfamily.


ensembl_gene_id: Spro_0681
symbol: Spro_0681
gene_biotype: protein_coding
description:
  Two component transcriptional regulator, winged helix family; PFAM: response regulator receiver; transcriptional regulator domain protein; KEGG: yen:YE0595 aerobic respiration control protein.


ensembl_gene_id: Spro_0682
symbol: trmJ
gene_biotype: protein_coding
description:
  RNA methyltransferase, TrmH family, group 1; Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA.


ensembl_gene_id: Spro_0683
symbol: Spro_0683
gene_biotype: protein_coding
description:
  Aspartate kinase; KEGG: yps:YPTB0602 bifunctional ThrA; aspartokinase I and homoserine dehydrogenase I (C-terminal); TIGRFAM: aspartate kinase; PFAM: aspartate/glutamate/uridylate kinase; homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase NAD-binding.


ensembl_gene_id: Spro_0684
symbol: thrB
gene_biotype: protein_coding
description:
  Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.


ensembl_gene_id: Spro_0685
symbol: Spro_0685
gene_biotype: protein_coding
description:
  KEGG: yps:YPTB0604 threonine synthase; TIGRFAM: threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit.


ensembl_gene_id: Spro_0686
symbol: Spro_0686
gene_biotype: protein_coding
description:
  PFAM: protein of unknown function DUF328; KEGG: yen:YE0603 hypothetical protein; Belongs to the UPF0246 family.


ensembl_gene_id: Spro_0687
symbol: Spro_0687
gene_biotype: protein_coding
description:
  TIGRFAM: amino acid carrier protein; PFAM: sodium:alanine symporter; KEGG: plu:plu2791 unnamed protein product; highly similar to probable amino acid transport protein YaaJ, sodium-dependent of Escherichia coli.


ensembl_gene_id: Spro_0688
symbol: tal
gene_biotype: protein_coding
description:
  Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.


ensembl_gene_id: Spro_0689
symbol: Spro_0689
gene_biotype: protein_coding
description:
  TIGRFAM: molybdenum cofactor synthesis domain; PFAM: molybdopterin binding domain; KEGG: ecv:APECO1_1969 molybdopterin biosynthesis Mog protein.


ensembl_gene_id: Spro_0690
symbol: Spro_0690
gene_biotype: protein_coding
description:
  PFAM: General substrate transporter; major facilitator superfamily MFS_1; KEGG: yen:YE0606 putative transport protein.


ensembl_gene_id: Spro_0693
symbol: dnaJ
gene_biotype: protein_coding
description:
  Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]


ensembl_gene_id: Spro_0694
symbol: nhaA
gene_biotype: protein_coding
description:
  Na+/H+ antiporter NhaA; Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons; Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.


ensembl_gene_id: Spro_0697
symbol: Spro_0697
gene_biotype: protein_coding
description:
  KEGG: ypi:YpsIP31758_3461 riboflavin biosynthesis protein RibF; TIGRFAM: riboflavin biosynthesis protein RibF; PFAM: cytidylyltransferase; FAD synthetase; Riboflavin kinase; Belongs to the ribF family.


ensembl_gene_id: Spro_0698
symbol: ileS
gene_biotype: protein_coding
description:
  isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.


ensembl_gene_id: Spro_0699
symbol: lspA
gene_biotype: protein_coding
description:
  Lipoprotein signal peptidase; This protein specifically catalyzes the removal of signal peptides from prolipoproteins; Belongs to the peptidase A8 family.


ensembl_gene_id: Spro_0700
symbol: Spro_0700
gene_biotype: protein_coding
description:
  PFAM: peptidylprolyl isomerase FKBP-type; KEGG: ypp:YPDSF_3155 FKBP-type peptidyl-prolyl cis-trans isomerase.


ensembl_gene_id: Spro_0701
symbol: ispH
gene_biotype: protein_coding
description:
  Hydroxymethylbutenyl pyrophosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.


ensembl_gene_id: Spro_0702
symbol: Spro_0702
gene_biotype: protein_coding
description:
  Transcriptional regulator, LysR family; PFAM: regulatory protein LysR; LysR substrate-binding; KEGG: pmy:Pmen_0810 transcriptional regulator, LysR family.


ensembl_gene_id: Spro_0705
symbol: Spro_0705
gene_biotype: protein_coding
description:
  TIGRFAM: glycosyltransferase, MGT family; PFAM: glycosyl transferase family 28; KEGG: eca:ECA3379 putative glycosyltransferase.


ensembl_gene_id: Spro_0706
symbol: Spro_0706
gene_biotype: protein_coding
description:
  PFAM: short-chain dehydrogenase/reductase SDR; KEGG: bxe:Bxe_A0545 putative short-chain dehydrogenase/reductase, FabG-like.


ensembl_gene_id: Spro_0707
symbol: Spro_0707
gene_biotype: protein_coding
description:
  PFAM: dihydrodipicolinate synthetase; KEGG: vvy:VVA1582 putative dihydrodipicolinate synthase; Belongs to the DapA family.


ensembl_gene_id: Spro_0708
symbol: Spro_0708
gene_biotype: protein_coding
description:
  KEGG: vvy:VVA1581 putative dihydroxy-acid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family.


ensembl_gene_id: Spro_0709
symbol: Spro_0709
gene_biotype: protein_coding
description:
  PFAM: major facilitator superfamily MFS_1; KEGG: rso:RSc2352 probable permease transmembrane protein.


ensembl_gene_id: Spro_0710
symbol: Spro_0710
gene_biotype: protein_coding
description:
  Sugar transporter; KEGG: ecs:ECs3819 galactose-proton symport of transport system; TIGRFAM: sugar transporter; PFAM: General substrate transporter; major facilitator superfamily MFS_1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.


ensembl_gene_id: Spro_0712
symbol: dapB
gene_biotype: protein_coding
description:
  Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family.


ensembl_gene_id: Spro_0713
symbol: carA
gene_biotype: protein_coding
description:
  TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: glutamine amidotransferase class-I; Carbamoyl-phosphate synthase small chain; KEGG: yen:YE0621 carbamoyl-phosphate synthase small chain; Belongs to the CarA family.


ensembl_gene_id: Spro_0714
symbol: carB
gene_biotype: protein_coding
description:
  TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: protein of unknown function DUF201; Carbamoyl-phosphate synthase L chain ATP-binding; Carbamoyl-phosphate synthetase large chain oligomerisation; Carbamoyl-phosphate synthetase large chain domain protein; MGS domain protein; KEGG: yen:YE0622 carbamoyl-phosphate synthase large chain; Belongs to the CarB family.


ensembl_gene_id: Spro_0715
symbol: kefF
gene_biotype: protein_coding
description:
  NAD(P)H dehydrogenase (quinone); Regulatory subunit of a potassium efflux system that confers protection against electrophiles. Required for full activity of KefC. Shows redox enzymatic activity, but this enzymatic activity is not required for activation of KefC; Belongs to the NAD(P)H dehydrogenase (quinone) family. KefF subfamily.


ensembl_gene_id: Spro_0716
symbol: kefC
gene_biotype: protein_coding
description:
  Potassium efflux system protein; Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport.


ensembl_gene_id: Spro_0720
symbol: Spro_0720
gene_biotype: protein_coding
description:
  Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.


ensembl_gene_id: Spro_0721
symbol: Spro_0721
gene_biotype: protein_coding
description:
  PFAM: protein of unknown function DUF839; KEGG: pfl:PFL_5696 Tat (twin-arginine translocation) pathway signal sequence domain protein.


ensembl_gene_id: Spro_0722
symbol: apaH
gene_biotype: protein_coding
description:
  Bis(5'nucleosyl)-tetraphosphatase, ApaH; Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP; Belongs to the Ap4A hydrolase family.


ensembl_gene_id: Spro_0724
symbol: rsmA
gene_biotype: protein_coding
description:
  Dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.


ensembl_gene_id: Spro_0725
symbol: pdxA
gene_biotype: protein_coding
description:
  4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).


ensembl_gene_id: Spro_0726
symbol: surA
gene_biotype: protein_coding
description:
  SurA domain; Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation.


ensembl_gene_id: Spro_0727
symbol: lptD
gene_biotype: protein_coding
description:
  Organic solvent tolerance protein; Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.


ensembl_gene_id: Spro_0728
symbol: djlA
gene_biotype: protein_coding
description:
  Heat shock protein DnaJ domain protein; Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB/RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host.


ensembl_gene_id: Spro_0730
symbol: rapA
gene_biotype: protein_coding
description:
  SNF2-related protein; Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair; Belongs to the SNF2/RAD54 helicase family. RapA subfamily.


ensembl_gene_id: Spro_0731
symbol: Spro_0731
gene_biotype: protein_coding
description:
  KEGG: yen:YE0637 DNA polymerase II; PFAM: DNA polymerase B exonuclease; DNA polymerase B region; SMART: DNA-directed DNA polymerase B.


ensembl_gene_id: Spro_0733
symbol: Spro_0733
gene_biotype: protein_coding
description:
  PFAM: amino acid-binding ACT domain protein; KEGG: eca:ECA3849 acetolactate synthase isozyme I small subunit.


ensembl_gene_id: Spro_0734
symbol: Spro_0734
gene_biotype: protein_coding
description:
  TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: eca:ECA3848 acetolactate synthase isozyme I large subunit.


ensembl_gene_id: Spro_0735
symbol: thiQ
gene_biotype: protein_coding
description:
  ABC transporter, ATPase subunit, ThiQ subfamily; Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Thiamine importer (TC 3.A.1.19.1) family.


ensembl_gene_id: Spro_0736
symbol: Spro_0736
gene_biotype: protein_coding
description:
  TIGRFAM: thiamine ABC transporter, inner membrane subunit; PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: ypi:YpsIP31758_3415 thiamine/thiamine pyrophosphate ABC transporter, permease protein.


ensembl_gene_id: Spro_0737
symbol: Spro_0737
gene_biotype: protein_coding
description:
  TIGRFAM: ABC transporter, periplasmic binding protein, thiB subfamily; thiamine ABC transporter, periplasmic binding protein; PFAM: extracellular solute-binding protein family 1; KEGG: yen:YE0642 thiamine-binding periplasmic protein.


ensembl_gene_id: Spro_0738
symbol: sgrR
gene_biotype: protein_coding
description:
  Extracellular solute-binding protein family 5; Activates the small RNA gene sgrS under glucose-phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain.


ensembl_gene_id: Spro_0740
symbol: Spro_0740
gene_biotype: protein_coding
description:
  TIGRFAM: sugar efflux transporter; PFAM: major facilitator superfamily MFS_1; KEGG: yen:YE0648 sugar efflux transporter.


ensembl_gene_id: Spro_0741
symbol: Spro_0741
gene_biotype: protein_coding
description:
  TIGRFAM: anion transporter; PFAM: sodium/sulphate symporter; Citrate transporter; TRAP C4-dicarboxylate transport system permease DctM subunit; KEGG: rfr:Rfer_1465 anion transporter.


ensembl_gene_id: Spro_0742
symbol: leuD
gene_biotype: protein_coding
description:
  3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.


ensembl_gene_id: Spro_0743
symbol: leuC
gene_biotype: protein_coding
description:
  3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.


ensembl_gene_id: Spro_0744
symbol: leuB
gene_biotype: protein_coding
description:
  3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.


ensembl_gene_id: Spro_0745
symbol: leuA
gene_biotype: protein_coding
description:
  2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.


ensembl_gene_id: Spro_0746
symbol: Spro_0746
gene_biotype: protein_coding
description:
  Transcriptional regulator, LysR family; PFAM: regulatory protein LysR; LysR substrate-binding; KEGG: ypi:YpsIP31758_3403 substrate-binding transcriptional regulator, LysR family.


ensembl_gene_id: Spro_0748
symbol: Spro_0748
gene_biotype: protein_coding
description:
  KEGG: yen:YE0658 acetolactate synthase isozyme III large subunit; TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein.


ensembl_gene_id: Spro_0749
symbol: Spro_0749
gene_biotype: protein_coding
description:
  TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: yen:YE0659 acetolactate synthase isozyme III small subunit.


ensembl_gene_id: Spro_0750
symbol: Spro_0750
gene_biotype: protein_coding
description:
  Transcriptional regulator, LacI family; TIGRFAM: D-fructose-responsive transcription factor; PFAM: regulatory protein LacI; periplasmic binding protein/LacI transcriptional regulator; KEGG: yen:YE0661 putative fructose repressor.


ensembl_gene_id: Spro_0752
symbol: mraZ
gene_biotype: protein_coding
description:
  MraZ protein; Negatively regulates its own expression and that of the subsequent genes in the proximal part of the division and cell wall (dcw) gene cluster. Acts by binding directly to DNA. May also regulate the expression of genes outside the dcw cluster.


ensembl_gene_id: Spro_0753
symbol: rsmH
gene_biotype: protein_coding
description:
  S-adenosyl-methyltransferase MraW; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.


ensembl_gene_id: Spro_0754
symbol: ftsL
gene_biotype: protein_coding
description:
  Cell division protein FtsL; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.


ensembl_gene_id: Spro_0755
symbol: ftsI
gene_biotype: protein_coding
description:
  Peptidoglycan glycosyltransferase; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum; Belongs to the transpeptidase family. FtsI subfamily.


ensembl_gene_id: Spro_0756
symbol: murE
gene_biotype: protein_coding
description:
  UDP-N-acetylmuramyl-tripeptide synthetase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily.


ensembl_gene_id: Spro_0757
symbol: murF
gene_biotype: protein_coding
description:
  UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanyl ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily.


ensembl_gene_id: Spro_0758
symbol: mraY
gene_biotype: protein_coding
description:
  phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily.


ensembl_gene_id: Spro_0759
symbol: murD
gene_biotype: protein_coding
description:
  UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family.


ensembl_gene_id: Spro_0760
symbol: ftsW
gene_biotype: protein_coding
description:
  Cell division protein FtsW; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily.


ensembl_gene_id: Spro_0761
symbol: murG
gene_biotype: protein_coding
description:
  Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily.


ensembl_gene_id: Spro_0763
symbol: ddl
gene_biotype: protein_coding
description:
  D-alanine--D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family.


ensembl_gene_id: Spro_0764
symbol: ftsQ
gene_biotype: protein_coding
description:
  Polypeptide-transport-associated domain protein FtsQ-type; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly.


ensembl_gene_id: Spro_0765
symbol: ftsA
gene_biotype: protein_coding
description:
  Cell division protein FtsA; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family.


ensembl_gene_id: Spro_0766
symbol: ftsZ
gene_biotype: protein_coding
description:
  Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.


ensembl_gene_id: Spro_0767
symbol: lpxC
gene_biotype: protein_coding
description:
  UDP-3-0-acyl N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family.


ensembl_gene_id: Spro_0769
symbol: secM
gene_biotype: protein_coding
description:
  Secretion monitor family proten; Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation. Belongs to the SecM family.


ensembl_gene_id: Spro_0770
symbol: secA
gene_biotype: protein_coding
description:
  Preprotein translocase, SecA subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.


ensembl_gene_id: Spro_0772
symbol: yacG
gene_biotype: protein_coding
description:
  Protein of unknown function DUF329; Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C- terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.


ensembl_gene_id: Spro_0773
symbol: zapD
gene_biotype: protein_coding
description:
  Protein of unknown function DUF1342; Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity.


ensembl_gene_id: Spro_0774
symbol: coaE
gene_biotype: protein_coding
description:
  dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family.


ensembl_gene_id: Spro_0775
symbol: guaC
gene_biotype: protein_coding
description:
  Guanosine monophosphate reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.


ensembl_gene_id: Spro_0776
symbol: Spro_0776
gene_biotype: protein_coding
description:
  PFAM: type II secretion system protein; KEGG: ypi:YpsIP31758_3372 putative protein transport protein HofC.


ensembl_gene_id: Spro_0778
symbol: Spro_0778
gene_biotype: protein_coding
description:
  KEGG: yen:YE0690 putative prepilin peptidase dependent protein D precursor; Belongs to the N-Me-Phe pilin family.


ensembl_gene_id: Spro_0779
symbol: Spro_0779
gene_biotype: protein_coding
description:
  KEGG: yen:YE0691 nicotinate-nucleotide pyrophosphorylase; TIGRFAM: nicotinate-nucleotide pyrophosphorylase; PFAM: Quinolinate phosphoribosyl transferase; Belongs to the NadC/ModD family.


ensembl_gene_id: Spro_0781
symbol: hemL
gene_biotype: protein_coding
description:
  TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III; KEGG: yen:YE0734 glutamate-1-semialdehyde 2,1-aminomutase.


ensembl_gene_id: Spro_0782
symbol: clcA
gene_biotype: protein_coding
description:
  Chloride channel core; Probably acts as an electrical shunt for an outwardly- directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response. Belongs to the chloride channel (TC 2.A.49) family. ClcA subfamily.


ensembl_gene_id: Spro_0783
symbol: erpA
gene_biotype: protein_coding
description:
  Iron-sulfur cluster assembly accessory protein; Required for insertion of 4Fe-4S clusters for at least IspG.


ensembl_gene_id: Spro_0786
symbol: btuF
gene_biotype: protein_coding
description:
  Periplasmic binding protein; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC.


ensembl_gene_id: Spro_0787
symbol: mtnN
gene_biotype: protein_coding
description:
  Adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine. Thus, is required for in vivo function of the radical SAM enzymes biotin synthase and lipoic acid synthase, that are inhibited by 5'-deoxyadenosine accumulation. Belongs to the PNP/UDP [...]


ensembl_gene_id: Spro_0788
symbol: dgt
gene_biotype: protein_coding
description:
  Putative deoxyguanosinetriphosphate triphosphohydrolase; dGTPase preferentially hydrolyzes dGTP over the other canonical NTPs; Belongs to the dGTPase family. Type 1 subfamily.


ensembl_gene_id: Spro_0789
symbol: Spro_0789
gene_biotype: protein_coding
description:
  Protease Do; KEGG: yen:YE0741 global stress requirement protein GsrA; TIGRFAM: protease Do; PFAM: peptidase S1 and S6 chymotrypsin/Hap; PDZ/DHR/GLGF domain protein; Belongs to the peptidase S1C family.


ensembl_gene_id: Spro_0790
symbol: Spro_0790
gene_biotype: protein_coding
description:
  Multi-sensor hybrid histidine kinase; PFAM: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; Hpt domain protein; KEGG: ypm:YP_0304 two-component regulatory protein.


ensembl_gene_id: Spro_0792
symbol: Spro_0792
gene_biotype: protein_coding
description:
  (p)ppGpp synthetase I, SpoT/RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.


ensembl_gene_id: Spro_0793
symbol: Spro_0793
gene_biotype: protein_coding
description:
  TIGRFAM: MazG family protein; PFAM: MazG nucleotide pyrophosphohydrolase; KEGG: ypi:YpsIP31758_3318 MazG family protein.


ensembl_gene_id: Spro_0794
symbol: pyrG
gene_biotype: protein_coding
description:
  CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.


ensembl_gene_id: Spro_0795
symbol: eno
gene_biotype: protein_coding
description:
  Phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.


ensembl_gene_id: Spro_0796
symbol: Spro_0796
gene_biotype: protein_coding
description:
  PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: pap:PSPA7_2666 hypothetical protein.


ensembl_gene_id: Spro_0798
symbol: Spro_0798
gene_biotype: protein_coding
description:
  KEGG: pfl:PFL_3514 methionine gamma-lyase; TIGRFAM: methionine gamma-lyase; PFAM: aminotransferase class V; Cys/Met metabolism pyridoxal-phosphate-dependent protein; DegT/DnrJ/EryC1/StrS aminotransferase; aromatic amino acid beta-eliminating lyase/threonine aldolase; Aluminium resistance family protein.


ensembl_gene_id: Spro_0799
symbol: Spro_0799
gene_biotype: protein_coding
description:
  KEGG: psb:Psyr_4832 histidine ammonia-lyase; TIGRFAM: histidine ammonia-lyase; PFAM: phenylalanine/histidine ammonia-lyase.


ensembl_gene_id: Spro_0800
symbol: Spro_0800
gene_biotype: protein_coding
description:
  ABC transporter-related protein; PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: pae:PA5094 putative glycine betaine/proline transport system ATP-binding protein.


ensembl_gene_id: Spro_0801
symbol: Spro_0801
gene_biotype: protein_coding
description:
  PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: pau:PA14_67280 putative amino acid transporter permease protein.


ensembl_gene_id: Spro_0802
symbol: Spro_0802
gene_biotype: protein_coding
description:
  PFAM: Substrate-binding region of ABC-type glycine betaine transport system; KEGG: pfo:Pfl_0362 substrate-binding region of ABC-type glycine betaine transport system.


ensembl_gene_id: Spro_0804
symbol: hutH
gene_biotype: protein_coding
description:
  KEGG: yen:YE4094 histidine ammonia-lyase; TIGRFAM: histidine ammonia-lyase; PFAM: phenylalanine/histidine ammonia-lyase.


ensembl_gene_id: Spro_0807
symbol: Spro_0807
gene_biotype: protein_coding
description:
  PFAM: General substrate transporter; major facilitator superfamily MFS_1; KEGG: reh:H16_B2293 4-hydroxybenzoate transporter, MFS-type AAHS family.


ensembl_gene_id: Spro_0808
symbol: queE
gene_biotype: protein_coding
description:
  Radical SAM domain protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.


ensembl_gene_id: Spro_0809
symbol: Spro_0809
gene_biotype: protein_coding
description:
  PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; KEGG: ypi:YpsIP31758_3312 putative 6-pyruvoyl tetrahydrobiopterin synthase.


ensembl_gene_id: Spro_0810
symbol: cysJ
gene_biotype: protein_coding
description:
  Sulfite reductase (NADPH) flavoprotein, alpha chain; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component; Belongs to the NADPH-dependent sulphite reductase flavoprotein subunit CysJ family. In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.


ensembl_gene_id: Spro_0811
symbol: cysI
gene_biotype: protein_coding
description:
  Sulfite reductase (NADPH) hemoprotein, beta-component; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.


ensembl_gene_id: Spro_0812
symbol: cysH
gene_biotype: protein_coding
description:
  Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily.


ensembl_gene_id: Spro_0817
symbol: cysG1
gene_biotype: protein_coding
description:
  uroporphyrin-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.


ensembl_gene_id: Spro_0818
symbol: cysD
gene_biotype: protein_coding
description:
  TIGRFAM: sulfate adenylyltransferase, small subunit; PFAM: phosphoadenosine phosphosulfate reductase; KEGG: yen:YE0762 sulfate adenylyltransferase subunit 2.


ensembl_gene_id: Spro_0819
symbol: cysN
gene_biotype: protein_coding
description:
  Sulfate adenylyltransferase, large subunit; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily.


ensembl_gene_id: Spro_0822
symbol: Spro_0822
gene_biotype: protein_coding
description:
  ABC transporter-related protein; PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: eca:ECA3539 amino acid ABC transporter, ATP-binding protein.


ensembl_gene_id: Spro_0823
symbol: Spro_0823
gene_biotype: protein_coding
description:
  TIGRFAM: polar amino acid ABC transporter, inner membrane subunit; PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: eca:ECA3538 amino acid ABC transporter.


ensembl_gene_id: Spro_0824
symbol: Spro_0824
gene_biotype: protein_coding
description:
  PFAM: extracellular solute-binding protein family 3; SMART: ionotropic glutamate receptor; KEGG: eca:ECA3537 amino acid-binding protein.


ensembl_gene_id: Spro_0825
symbol: ftsB
gene_biotype: protein_coding
description:
  Septum formation initiator; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.


ensembl_gene_id: Spro_0826
symbol: ispD
gene_biotype: protein_coding
description:
  2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.


ensembl_gene_id: Spro_0827
symbol: ispF
gene_biotype: protein_coding
description:
  2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).


ensembl_gene_id: Spro_0828
symbol: truD
gene_biotype: protein_coding
description:
  tRNA pseudouridine synthase D TruD; Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs; Belongs to the pseudouridine synthase TruD family.


ensembl_gene_id: Spro_0829
symbol: surE
gene_biotype: protein_coding
description:
  Stationary-phase survival protein SurE; Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs.


ensembl_gene_id: Spro_0830
symbol: pcm
gene_biotype: protein_coding
description:
  protein-L-isoaspartate O-methyltransferase; Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.


ensembl_gene_id: Spro_0832
symbol: rpoS
gene_biotype: protein_coding
description:
  RNA polymerase, sigma 70 subunit, RpoD family; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response.


ensembl_gene_id: Spro_0833
symbol: mutS
gene_biotype: protein_coding
description:
  DNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.


ensembl_gene_id: Spro_0834
symbol: Spro_0834
gene_biotype: protein_coding
description:
  TIGRFAM: PTS system, lactose/cellobiose family IIB subunit; PFAM: phosphotransferase system lactose/cellobiose-specific IIB subunit; KEGG: ypm:YP_2480 PTS system, cellobiose-specific IIB component.


ensembl_gene_id: Spro_0835
symbol: Spro_0835
gene_biotype: protein_coding
description:
  PTS system, lactose/cellobiose family IIC subunit; The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane.


ensembl_gene_id: Spro_0836
symbol: Spro_0836
gene_biotype: protein_coding
description:
  Beta-glucosidase; PFAM: glycoside hydrolase family 1; KEGG: yen:YE0969 putative glycosyl hydrolase; Belongs to the glycosyl hydrolase 1 family.


ensembl_gene_id: Spro_0837
symbol: Spro_0837
gene_biotype: protein_coding
description:
  Transcriptional regulator, AraC family; PFAM: helix-turn-helix- domain containing protein AraC type; Cupin 2 conserved barrel domain protein; KEGG: yen:YE0971 cel operon repressor.


ensembl_gene_id: Spro_0838
symbol: chbG
gene_biotype: protein_coding
description:
  YdjC family protein; Involved in the degradation of chitin. ChbG is essential for growth on the acetylated chitooligosaccharides chitobiose and chitotriose but is dispensable for growth on cellobiose and chitosan dimer, the deacetylated form of chitobiose. Deacetylation of chitobiose-6-P and chitotriose-6-P is necessary for both the activation of the chb promoter by the regulatory protein ChbR and the hydrolysis of phosphorylated beta-glucosides by the phospho-beta-glucosidase ChbF. Catalyzes the removal of only one acetyl group from chitobiose-6-P to yield monoacetylchitobiose-6-P, th [...]


ensembl_gene_id: Spro_0840
symbol: Spro_0840
gene_biotype: protein_coding
description:
  PFAM: CinA domain protein; KEGG: ypi:YpsIP31758_3241 competence/damage-inducible protein CinA domain protein; Belongs to the CinA family.


ensembl_gene_id: Spro_0841
symbol: recA
gene_biotype: protein_coding
description:
  recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.


ensembl_gene_id: Spro_0843
symbol: alaS
gene_biotype: protein_coding
description:
  alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain; Belongs to the class-II aminoacyl-tRNA synthetase family.


ensembl_gene_id: Spro_0844
symbol: Spro_0844
gene_biotype: protein_coding
description:
  PFAM: carbon storage regulator; KEGG: plu:plu1251 carbon storage regulator homolog; Belongs to the CsrA/RsmA family.


ensembl_gene_id: Spro_0845
symbol: Spro_0845
gene_biotype: protein_coding
description:
  TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; HAD-superfamily hydrolase, subfamily IA, variant 1; beta-phosphoglucomutase family hydrolase; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: yen:YE0836 putative hydrolase.


ensembl_gene_id: Spro_0847
symbol: gshA
gene_biotype: protein_coding
description:
  TIGRFAM: glutamate--cysteine ligase; KEGG: yen:YE0838 glutamate--cysteine ligase; Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily.


ensembl_gene_id: Spro_0848
symbol: luxS
gene_biotype: protein_coding
description:
  Quorum-sensing autoinducer 2 (AI-2), LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family.


ensembl_gene_id: Spro_0849
symbol: Spro_0849
gene_biotype: protein_coding
description:
  PFAM: CBS domain containing protein; protein of unknown function DUF21; transporter-associated region; KEGG: yen:YE0840 hypothetical protein.


ensembl_gene_id: Spro_0851
symbol: ffh
gene_biotype: protein_coding
description:
  Signal recognition particle protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual componen [...]


ensembl_gene_id: Spro_0852
symbol: rpsP
gene_biotype: protein_coding
description:
  PFAM: ribosomal protein S16; KEGG: ypi:YpsIP31758_3228 ribosomal protein S16; Belongs to the bacterial ribosomal protein bS16 family.


ensembl_gene_id: Spro_0853
symbol: rimM
gene_biotype: protein_coding
description:
  16S rRNA processing protein RimM; An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes; Belongs to the RimM family.


ensembl_gene_id: Spro_0854
symbol: trmD
gene_biotype: protein_coding
description:
  tRNA (guanine-N1)-methyltransferase; Specifically methylates guanosine-37 in various tRNAs. Belongs to the RNA methyltransferase TrmD family.


ensembl_gene_id: Spro_0855
symbol: rplS
gene_biotype: protein_coding
description:
  Ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.


ensembl_gene_id: Spro_0857
symbol: Spro_0857
gene_biotype: protein_coding
description:
  PFAM: late control D family protein; KEGG: yps:YPTB1739 similar to D protein bacteriophage 186 and P2.


ensembl_gene_id: Spro_0859
symbol: Spro_0859
gene_biotype: protein_coding
description:
  TIGRFAM: phage tail tape measure protein, TP901 family; KEGG: ent:Ent638_1357 phage tail-like protein.


ensembl_gene_id: Spro_0862
symbol: Spro_0862
gene_biotype: protein_coding
description:
  TIGRFAM: phage major tail tube protein; PFAM: major tail tube protein; KEGG: yps:YPTB1744 putative tail tube protein FII (bacteriophage P2).


ensembl_gene_id: Spro_0863
symbol: Spro_0863
gene_biotype: protein_coding
description:
  PFAM: tail sheath protein; KEGG: yps:YPTB1745 putative tail sheath protein (P2 and 186 bacteriophage).


ensembl_gene_id: Spro_0869
symbol: Spro_0869
gene_biotype: protein_coding
description:
  TIGRFAM: phage baseplate assembly protein V; PFAM: baseplate assembly protein V; KEGG: yps:YPTB1751 putative phage-related baseplate assembly protein.


ensembl_gene_id: Spro_0875
symbol: Spro_0875
gene_biotype: protein_coding
description:
  Transcriptional regulator, TraR/DksA family; TIGRFAM: phage/conjugal plasmid C-4 type zinc finger protein, TraR family; PFAM: zinc finger DksA/TraR C4-type; KEGG: yen:YE1687 hypothetical 8.2 kDa protein in gpa 5'region.


ensembl_gene_id: Spro_0879
symbol: Spro_0879
gene_biotype: protein_coding
description:
  Phospho-2-dehydro-3-deoxyheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP).


ensembl_gene_id: Spro_0880
symbol: Spro_0880
gene_biotype: protein_coding
description:
  TIGRFAM: chorismate mutase; PFAM: Chorismate mutase; Prephenate dehydrogenase; KEGG: yen:YE0851 T-protein.


ensembl_gene_id: Spro_0881
symbol: Spro_0881
gene_biotype: protein_coding
description:
  TIGRFAM: chorismate mutase; PFAM: prephenate dehydratase; Chorismate mutase; KEGG: yen:YE0852 P-protein.


ensembl_gene_id: Spro_0882
symbol: Spro_0882
gene_biotype: protein_coding
description:
  TIGRFAM: ribosomal subunit interface protein; PFAM: sigma 54 modulation protein/ribosomal protein S30EA; KEGG: ypi:YpsIP31758_3216 ribosomal subunit interface protein.


ensembl_gene_id: Spro_0883
symbol: bamD
gene_biotype: protein_coding
description:
  Putative lipoprotein; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamA, the core component of the assembly machinery.


ensembl_gene_id: Spro_0884
symbol: Spro_0884
gene_biotype: protein_coding
description:
  Pseudouridine synthase, RluA family; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family.


ensembl_gene_id: Spro_0885
symbol: Spro_0885
gene_biotype: protein_coding
description:
  PFAM: protein of unknown function DUF152; KEGG: yen:YE0892 hypothetical protein; Belongs to the multicopper oxidase YfiH/RL5 family.


ensembl_gene_id: Spro_0886
symbol: clpB
gene_biotype: protein_coding
description:
  ATPase AAA-2 domain protein; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family.


ensembl_gene_id: Spro_0891
symbol: acpP
gene_biotype: protein_coding
description:
  Phosphopantetheine-binding; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family.


ensembl_gene_id: Spro_0894
symbol: Spro_0894
gene_biotype: protein_coding
description:
  PFAM: Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabA/FabZ; KEGG: yen:YE0902 putative dehydratase.


ensembl_gene_id: Spro_0895
symbol: Spro_0895
gene_biotype: protein_coding
description:
  PFAM: glycosyl transferase family 2; KEGG: yen:YE0903 putative bifunctional glycosyl transferase/acyl transferase.


ensembl_gene_id: Spro_0897
symbol: Spro_0897
gene_biotype: protein_coding
description:
  Putative outer-membrane lipoprotein carrier protein; Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).


ensembl_gene_id: Spro_0900
symbol: Spro_0900
gene_biotype: protein_coding
description:
  PFAM: Beta-ketoacyl synthase; KEGG: yen:YE0908 putative beta-ketoacyl-[ACP] synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.


ensembl_gene_id: Spro_0901
symbol: Spro_0901
gene_biotype: protein_coding
description:
  PFAM: Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabA/FabZ; KEGG: yen:YE0909 putative dehydratase.


ensembl_gene_id: Spro_0902
symbol: Spro_0902
gene_biotype: protein_coding
description:
  TIGRFAM: 3-oxoacyl-(acyl-carrier-protein) reductase, putative; PFAM: short-chain dehydrogenase/reductase SDR; KR domain protein; KEGG: yen:YE0910 3-oxoacyl-[acyl-carrier protein] reductase.


ensembl_gene_id: Spro_0903
symbol: Spro_0903
gene_biotype: protein_coding
description:
  PFAM: Beta-ketoacyl synthase; KEGG: yen:YE0911 3-oxoacyl-[acyl-carrier-protein] synthase II; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.


ensembl_gene_id: Spro_0905
symbol: Spro_0905
gene_biotype: protein_coding
description:
  Transcriptional regulator, LysR family; PFAM: regulatory protein LysR; LysR substrate-binding; KEGG: yen:YE0914 putative LysR-family transcriptional regulatory protein.


ensembl_gene_id: Spro_0908
symbol: Spro_0908
gene_biotype: protein_coding
description:
  PFAM: Peptidoglycan-binding LysM; Lytic transglycosylase catalytic; MLTD_N domain protein; KEGG: yen:YE0918 membrane-bound lytic murein transglycosylase D precursor.


ensembl_gene_id: Spro_0909
symbol: gloB
gene_biotype: protein_coding
description:
  Hydroxyacylglutathione hydrolase; Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl- glutathione to form glutathione and D-lactic acid.


ensembl_gene_id: Spro_0912
symbol: dnaQ
gene_biotype: protein_coding
description:
  DNA polymerase III, epsilon subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease.


ensembl_gene_id: Spro_0913
symbol: Spro_0913
gene_biotype: protein_coding
description:
  PFAM: permease for cytosine/purines uracil thiamine allantoin; KEGG: kpn:KPN_01790 putative allantoin permease.


ensembl_gene_id: Spro_0914
symbol: Spro_0914
gene_biotype: protein_coding
description:
  Transcriptional regulator, GntR family; PFAM: regulatory protein GntR HTH; GntR domain protein; KEGG: kpn:KPN_01789 hypothetical transcriptional regulator.


ensembl_gene_id: Spro_0916
symbol: Spro_0916
gene_biotype: protein_coding
description:
  PFAM: polysaccharide deacetylase; KEGG: ypi:YpsIP31758_1058 polysaccharide deacetylase family protein.


ensembl_gene_id: Spro_0918
symbol: Spro_0918
gene_biotype: protein_coding
description:
  TIGRFAM: TonB-dependent siderophore receptor; PFAM: TonB-dependent receptor; TonB-dependent receptor plug; KEGG: ypi:YpsIP31758_0710 TonB-dependent siderophore receptor.


ensembl_gene_id: Spro_0919
symbol: Spro_0919
gene_biotype: protein_coding
description:
  L-lysine 6-monooxygenase (NADPH); KEGG: ypi:YpsIP31758_0711 aerobactin siderophore biosynthesis protein IucD.


ensembl_gene_id: Spro_0922
symbol: Spro_0922
gene_biotype: protein_coding
description:
  PFAM: IucA/IucC family protein; KEGG: ypi:YpsIP31758_0714 aerobactin siderophore biosynthesis protein IucA.


ensembl_gene_id: Spro_0924
symbol: Spro_0924
gene_biotype: protein_coding
description:
  PFAM: Siderophore-interacting protein; FAD-binding 9 siderophore-interacting domain protein; KEGG: eca:ECA0065 hypothetical protein.


ensembl_gene_id: Spro_0926
symbol: Spro_0926
gene_biotype: protein_coding
description:
  Transcriptional regulator, CopG family; PFAM: CopG domain protein DNA-binding domain protein; KEGG: plu:plu2305 hypothetical protein.


ensembl_gene_id: Spro_0928
symbol: Spro_0928
gene_biotype: protein_coding
description:
  TIGRFAM: Amidohydrolase AtzE type; PFAM: Amidase; KEGG: ypi:YpsIP31758_3194 amidohydrolase, AtzE family.


ensembl_gene_id: Spro_0930
symbol: Spro_0930
gene_biotype: protein_coding
description:
  Gamma-glutamyltransferase; PFAM: gamma-glutamyltranspeptidase; KEGG: eca:ECA3497 putative gamma-glutamyltranspeptidase.


ensembl_gene_id: Spro_0931
symbol: Spro_0931
gene_biotype: protein_coding
description:
  Transcriptional regulator, RpiR family; PFAM: helix-turn-helix protein RpiR; sugar isomerase (SIS); KEGG: eca:ECA3496 putative transcriptional regulator.


ensembl_gene_id: Spro_0932
symbol: Spro_0932
gene_biotype: protein_coding
description:
  PFAM: extracellular solute-binding protein family 3; KEGG: ypi:YpsIP31758_3190 amino acid ABC transporter, periplasmic amino acid-binding protein; Belongs to the bacterial solute-binding protein 3 family.


ensembl_gene_id: Spro_0933
symbol: Spro_0933
gene_biotype: protein_coding
description:
  TIGRFAM: polar amino acid ABC transporter, inner membrane subunit; PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: eca:ECA3494 putative amino acid ABC transporter, permease protein.


ensembl_gene_id: Spro_0934
symbol: Spro_0934
gene_biotype: protein_coding
description:
  TIGRFAM: polar amino acid ABC transporter, inner membrane subunit; PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: ypi:YpsIP31758_3188 amino acid ABC transporter, permease protein.


ensembl_gene_id: Spro_0935
symbol: Spro_0935
gene_biotype: protein_coding
description:
  ABC transporter-related protein; PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: eca:ECA3492 putative amino acid ABC transporter, ATP-binding protein.


ensembl_gene_id: Spro_0937
symbol: Spro_0937
gene_biotype: protein_coding
description:
  Amidase, hydantoinase/carbamoylase family; KEGG: yps:YPTB0871 N-carbamoyl-L-amino acid amidohydrolase; TIGRFAM: amidase, hydantoinase/carbamoylase family; PFAM: peptidase M20; peptidase dimerisation domain protein.


ensembl_gene_id: Spro_0939
symbol: Spro_0939
gene_biotype: protein_coding
description:
  PFAM: Transthyretin; KEGG: sen:SACE_6735 transthyretin; Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.


ensembl_gene_id: Spro_0940
symbol: Spro_0940
gene_biotype: protein_coding
description:
  PFAM: Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase; KEGG: ypi:YpsIP31758_3184 hydrolase, carbon-nitrogen family.


ensembl_gene_id: Spro_0942
symbol: mtnB
gene_biotype: protein_coding
description:
  Class II aldolase/adducin family protein; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Belongs to the aldolase class II family. MtnB subfamily.


ensembl_gene_id: Spro_0943
symbol: mtnC
gene_biotype: protein_coding
description:
  2,3-diketo-5-methylthio-1-phosphopentane phosphatase; Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.


ensembl_gene_id: Spro_0944
symbol: mtnD
gene_biotype: protein_coding
description:
  Acireductone dioxygenase ARD; Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.


ensembl_gene_id: Spro_0945
symbol: mtnA
gene_biotype: protein_coding
description:
  eIF-2B alpha/beta/delta-related uncharacterized protein; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).


ensembl_gene_id: Spro_0946
symbol: mtnK
gene_biotype: protein_coding
description:
  5-methylthioribose kinase; Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate.


ensembl_gene_id: Spro_0949
symbol: Spro_0949
gene_biotype: protein_coding
description:
  PFAM: acyl-CoA dehydrogenase domain protein; Protein of unknown function DUF1974; KEGG: yen:YE3224 probable acyl-CoA dehydrogenase.


ensembl_gene_id: Spro_0950
symbol: gmhA
gene_biotype: protein_coding
description:
  Phosphoheptose isomerase; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.


ensembl_gene_id: Spro_0953
symbol: nqrA
gene_biotype: protein_coding
description:
  NADH:ubiquinone oxidoreductase, subunit A; NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.


ensembl_gene_id: Spro_0954
symbol: nqrB
gene_biotype: protein_coding
description:
  NADH:ubiquinone oxidoreductase, subunit B; NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.


ensembl_gene_id: Spro_0955
symbol: nqrC
gene_biotype: protein_coding
description:
  NADH:ubiquinone oxidoreductase, subunit C; NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.


ensembl_gene_id: Spro_0956
symbol: nqrD
gene_biotype: protein_coding
description:
  NADH:ubiquinone oxidoreductase, subunit D; NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol; Belongs to the NqrDE/RnfAE family.


ensembl_gene_id: Spro_0957
symbol: nqrE
gene_biotype: protein_coding
description:
  NADH:ubiquinone oxidoreductase, subunit E; NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol; Belongs to the NqrDE/RnfAE family.


ensembl_gene_id: Spro_0958
symbol: nqrF
gene_biotype: protein_coding
description:
  NADH:ubiquinone oxidoreductase, subunit F; NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway.


ensembl_gene_id: Spro_0959
symbol: Spro_0959
gene_biotype: protein_coding
description:
  ApbE family lipoprotein; Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein. Belongs to the ApbE family.


ensembl_gene_id: Spro_0962
symbol: dinB
gene_biotype: protein_coding
description:
  DNA-directed DNA polymerase; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.


ensembl_gene_id: Spro_0963
symbol: Spro_0963
gene_biotype: protein_coding
description:
  KEGG: yen:YE3206 aminoacyl-histidine dipeptidase; TIGRFAM: aminoacyl-histidine dipeptidase; PFAM: peptidase M20; peptidase dimerisation domain protein.


ensembl_gene_id: Spro_0964
symbol: gpt
gene_biotype: protein_coding
description:
  Xanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily.


ensembl_gene_id: Spro_0965
symbol: Spro_0965
gene_biotype: protein_coding
description:
  PFAM: protein of unknown function DUF1100 hydrolase family protein; KEGG: yen:YE3204 hypothetical protein; Belongs to the UPF0255 family.


ensembl_gene_id: Spro_0966
symbol: crl
gene_biotype: protein_coding
description:
  Transcriptional regulator Crl; Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32; Belongs to the Crl family.


ensembl_gene_id: Spro_0967
symbol: proB
gene_biotype: protein_coding
description:
  Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.


ensembl_gene_id: Spro_0968
symbol: proA
gene_biotype: protein_coding
description:
  Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family.


ensembl_gene_id: Spro_0973
symbol: Spro_0973
gene_biotype: protein_coding
description:
  PFAM: extracellular solute-binding protein family 5; KEGG: kpn:KPN_01918 dipeptide transport protein.


ensembl_gene_id: Spro_0977
symbol: Spro_0977
gene_biotype: protein_coding
description:
  TIGRFAM: TonB-dependent siderophore receptor; PFAM: TonB-dependent receptor; TonB-dependent receptor plug; KEGG: vvy:VVA1309 ferric vulnibactin outer membrane receptor.


ensembl_gene_id: Spro_0978
symbol: Spro_0978
gene_biotype: protein_coding
description:
  PFAM: condensation domain protein; phosphopantetheine-binding; KEGG: vvu:VV2_0830 non-ribosomal peptide synthetase modules.


ensembl_gene_id: Spro_0980
symbol: Spro_0980
gene_biotype: protein_coding
description:
  PFAM: flavin reductase domain protein FMN-binding; KEGG: ent:Ent638_2072 flavin reductase domain protein, FMN-binding.


ensembl_gene_id: Spro_0984
symbol: Spro_0984
gene_biotype: protein_coding
description:
  Transcriptional regulator, AraC family; PFAM: helix-turn-helix- domain containing protein AraC type; KEGG: kpn:KPN_01454 2-phenylethylamine catabolism regulatory protein.


ensembl_gene_id: Spro_0985
symbol: Spro_0985
gene_biotype: protein_coding
description:
  PFAM: aldehyde dehydrogenase; KEGG: kpn:KPN_01455 phenylacetaldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.


ensembl_gene_id: Spro_0987
symbol: Spro_0987
gene_biotype: protein_coding
description:
  TIGRFAM: tellurite resistance protein TehB; PFAM: Tellurite resistance protein TehB; Methyltransferase type 11; Methyltransferase type 12; Protein of unknown function DUF1971; KEGG: eca:ECA0900 putative tellurite resistance protein.


ensembl_gene_id: Spro_0991
symbol: Spro_0991
gene_biotype: protein_coding
description:
  Transcriptional regulator, LysR family; PFAM: regulatory protein LysR; LysR substrate-binding; KEGG: rsq:Rsph17025_3347 hypothetical protein.


ensembl_gene_id: Spro_0992
symbol: Spro_0992
gene_biotype: protein_coding
description:
  PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: bxe:Bxe_B0109 putative pyruvate decarboxylase.


ensembl_gene_id: Spro_0993
symbol: pagP
gene_biotype: protein_coding
description:
  Antimicrobial peptide resistance and lipid A acylation PagP; Transfers a palmitate residue from the sn-1 position of a phospholipid to the N-linked hydroxymyristate on the proximal unit of lipid A or its precursors.


ensembl_gene_id: Spro_0997
symbol: Spro_0997
gene_biotype: protein_coding
description:
  Transcriptional regulator, DeoR family; PFAM: regulatory protein DeoR; Helix-turn-helix type 11 domain protein; KEGG: rsp:RSP_3064 transcriptional regulator, DeoR family.


ensembl_gene_id: Spro_0998
symbol: Spro_0998
gene_biotype: protein_coding
description:
  PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase; KEGG: ent:Ent638_0487 glyoxalase/bleomycin resistance protein/dioxygenase.


ensembl_gene_id: Spro_0999
symbol: Spro_0999
gene_biotype: protein_coding
description:
  Transcriptional regulator, LysR family; PFAM: regulatory protein LysR; LysR substrate-binding; KEGG: reh:H16_B1922 transcriptional regulator, LysR-family.


ensembl_gene_id: Spro_1003
symbol: Spro_1003
gene_biotype: protein_coding
description:
  PFAM: putative thiol-disulphide oxidoreductase DCC; KEGG: pfl:PFL_2261 protein of unknown function, DUF393 family.


ensembl_gene_id: Spro_1007
symbol: Spro_1007
gene_biotype: protein_coding
description:
  Transcriptional regulator, XRE family; SMART: helix-turn-helix domain protein; KEGG: eca:ECA3469 putative DNA-binding protein.


ensembl_gene_id: Spro_1008
symbol: Spro_1008
gene_biotype: protein_coding
description:
  Methyltransferase type 11; PFAM: UbiE/COQ5 methyltransferase; methyltransferase small; Methyltransferase type 11; Methyltransferase type 12; KEGG: yen:YE3193 hypothetical protein.


ensembl_gene_id: Spro_1009
symbol: aqpZ
gene_biotype: protein_coding
description:
  MIP family channel protein; Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity; Belongs to the MIP/aquaporin (TC 1.A.8) family.


ensembl_gene_id: Spro_1016
symbol: Spro_1016
gene_biotype: protein_coding
description:
  TIGRFAM: TonB-dependent siderophore receptor; PFAM: TonB-dependent receptor; TonB-dependent receptor plug; KEGG: yen:YE3189 putative hydroxamate-type ferrisiderophore receptor.


ensembl_gene_id: Spro_1018
symbol: aroL
gene_biotype: protein_coding
description:
  Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.


ensembl_gene_id: Spro_1019
symbol: Spro_1019
gene_biotype: protein_coding
description:
  Transcriptional regulator, AraC family; PFAM: helix-turn-helix- domain containing protein AraC type; KEGG: bur:Bcep18194_B1773 transcriptional regulator, AraC family.


ensembl_gene_id: Spro_1022
symbol: Spro_1022
gene_biotype: protein_coding
description:
  PFAM: regulatory protein IclR; Transcriptional regulator IclR; KEGG: bja:bll3245 transcriptional regulatory protein.


ensembl_gene_id: Spro_1023
symbol: Spro_1023
gene_biotype: protein_coding
description:
  PFAM: Oligopeptide transporter OPT superfamily protein; KEGG: vei:Veis_1103 oligopeptide transporter OPT superfamily protein.


ensembl_gene_id: Spro_1026
symbol: ppnP
gene_biotype: protein_coding
description:
  Protein of unknown function DUF1255; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions.


ensembl_gene_id: Spro_1028
symbol: Spro_1028
gene_biotype: protein_coding
description:
  Multi-sensor hybrid histidine kinase; TIGRFAM: PAS sensor protein; PFAM: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; PAS fold-4 domain protein; KEGG: ypi:YpsIP31758_4031 sensory box histidine kinase/response regulator.


ensembl_gene_id: Spro_1029
symbol: rbsA
gene_biotype: protein_coding
description:
  ABC transporter-related protein; Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Ribose importer (TC 3.A.1.2.1) family.


ensembl_gene_id: Spro_1030
symbol: Spro_1030
gene_biotype: protein_coding
description:
  Monosaccharide-transporting ATPase; PFAM: inner-membrane translocator; KEGG: kpn:KPN_04488 putative carbohydrate ABC transport system permease.


ensembl_gene_id: Spro_1031
symbol: Spro_1031
gene_biotype: protein_coding
description:
  PFAM: periplasmic binding protein/LacI transcriptional regulator; KEGG: kpn:KPN_04487 D-ribose periplasmic binding protein.


ensembl_gene_id: Spro_1033
symbol: Spro_1033
gene_biotype: protein_coding
description:
  Ketose-bisphosphate aldolase; KEGG: ypi:YpsIP31758_4026 putative fructose-bisphosphate aldolase; TIGRFAM: ketose-bisphosphate aldolase; PFAM: ketose-bisphosphate aldolase class-II.


ensembl_gene_id: Spro_1035
symbol: Spro_1035
gene_biotype: protein_coding
description:
  Two component transcriptional regulator, winged helix family; PFAM: response regulator receiver; transcriptional regulator domain protein; KEGG: ent:Ent638_0283 two component transcriptional regulator, winged helix family.


ensembl_gene_id: Spro_1039
symbol: sbcC
gene_biotype: protein_coding
description:
  Exonuclease SbcC; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SMC family. SbcC subfamily.


ensembl_gene_id: Spro_1040
symbol: sbcD
gene_biotype: protein_coding
description:
  Nuclease SbcCD, D subunit; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family.


ensembl_gene_id: Spro_1041
symbol: Spro_1041
gene_biotype: protein_coding
description:
  Two component transcriptional regulator, winged helix family; TIGRFAM: phosphate regulon transcriptional regulatory protein PhoB; PFAM: response regulator receiver; transcriptional regulator domain protein; KEGG: ypi:YpsIP31758_3136 phosphate regulon transcriptional regulatory protein PhoB.


ensembl_gene_id: Spro_1042
symbol: Spro_1042
gene_biotype: protein_coding
description:
  PAS/PAC sensor signal transduction histidine kinase; KEGG: yen:YE3181 phosphate regulon sensor protein PhoR; TIGRFAM: PAS sensor protein; Phosphate regulon sensor kinase PhoR; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold domain protein; SMART: PAS domain containing protein.


ensembl_gene_id: Spro_1044
symbol: Spro_1044
gene_biotype: protein_coding
description:
  PFAM: Methionine synthase vitamin-B12 independent; KEGG: eca:ECA1113 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase.


ensembl_gene_id: Spro_1045
symbol: Spro_1045
gene_biotype: protein_coding
description:
  Branched-chain amino acid transport system II carrier protein; Component of the transport system for branched-chain amino acids.


ensembl_gene_id: Spro_1048
symbol: Spro_1048
gene_biotype: protein_coding
description:
  PFAM: MscS Mechanosensitive ion channel; KEGG: ypi:YpsIP31758_1534 transporter, small conductance mechanosensitive ion channel (MscS) family.


ensembl_gene_id: Spro_1049
symbol: Spro_1049
gene_biotype: protein_coding
description:
  Alpha amylase catalytic region; PFAM: glycoside hydrolase family 13 domain protein Ig domain protein region domain protein; alpha amylase catalytic region; SMART: alpha amylase catalytic sub domain; KEGG: yen:YE3177 putative maltodextrin glucosidase; Belongs to the glycosyl hydrolase 13 family.


ensembl_gene_id: Spro_1050
symbol: Spro_1050
gene_biotype: protein_coding
description:
  Transcriptional regulator, LuxR family; PFAM: regulatory protein LuxR; KEGG: gme:Gmet_2158 two component transcriptional regulator, LuxR family.


ensembl_gene_id: Spro_1053
symbol: Spro_1053
gene_biotype: protein_coding
description:
  PFAM: fimbrial biogenesis outer membrane usher protein; KEGG: kpn:KPN_00277 putative fimbrial usher.


ensembl_gene_id: Spro_1057
symbol: Spro_1057
gene_biotype: protein_coding
description:
  Gamma-glutamyltransferase; KEGG: yen:YE3175 gamma-glutamyltranspeptidase precursor; TIGRFAM: gamma-glutamyltransferase; PFAM: gamma-glutamyltranspeptidase.


ensembl_gene_id: Spro_1058
symbol: Spro_1058
gene_biotype: protein_coding
description:
  PFAM: alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; Redoxin domain protein; KEGG: ypi:YpsIP31758_3126 antioxidant, AhpC/TSA family.


ensembl_gene_id: Spro_1059
symbol: acpH
gene_biotype: protein_coding
description:
  (Acyl-carrier-protein) phosphodiesterase; Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP; Belongs to the AcpH family.


ensembl_gene_id: Spro_1060
symbol: queA
gene_biotype: protein_coding
description:
  S-adenosylmethionine--tRNA-ribosyltransferase- isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).


ensembl_gene_id: Spro_1061
symbol: tgt
gene_biotype: protein_coding
description:
  Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form th [...]


ensembl_gene_id: Spro_1062
symbol: yajC
gene_biotype: protein_coding
description:
  Preprotein translocase, YajC subunit; The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions.


ensembl_gene_id: Spro_1063
symbol: secD
gene_biotype: protein_coding
description:
  Protein-export membrane protein SecD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.


ensembl_gene_id: Spro_1064
symbol: secF
gene_biotype: protein_coding
description:
  Protein-export membrane protein SecF; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.


ensembl_gene_id: Spro_1065
symbol: Spro_1065
gene_biotype: protein_coding
description:
  Two component transcriptional regulator, LuxR family; PFAM: regulatory protein LuxR; response regulator receiver; KEGG: stm:STM1387 response regulator.


ensembl_gene_id: Spro_1066
symbol: Spro_1066
gene_biotype: protein_coding
description:
  Histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; KEGG: yen:YE1614 tetrathionate reductase complex: sensory transduction histidine kinase.


ensembl_gene_id: Spro_1067
symbol: Spro_1067
gene_biotype: protein_coding
description:
  PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: yen:YE1615 tetrathionate reductase subunit B.


ensembl_gene_id: Spro_1069
symbol: Spro_1069
gene_biotype: protein_coding
description:
  PFAM: molydopterin dinucleotide-binding region; KEGG: yen:YE1617 tetrathionate reductase subunit A; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.


ensembl_gene_id: Spro_1071
symbol: nrdR
gene_biotype: protein_coding
description:
  ATP-cone domain protein; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family.


ensembl_gene_id: Spro_1072
symbol: Spro_1072
gene_biotype: protein_coding
description:
  Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.


ensembl_gene_id: Spro_1073
symbol: ribH
gene_biotype: protein_coding
description:
  6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family.


ensembl_gene_id: Spro_1074
symbol: nusB
gene_biotype: protein_coding
description:
  NusB antitermination factor; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.


ensembl_gene_id: Spro_1075
symbol: thiL
gene_biotype: protein_coding
description:
  Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family.


ensembl_gene_id: Spro_1076
symbol: Spro_1076
gene_biotype: protein_coding
description:
  Phosphatidylglycerophosphatase A; Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG).


ensembl_gene_id: Spro_1078
symbol: dxs
gene_biotype: protein_coding
description:
  Deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily.


ensembl_gene_id: Spro_1079
symbol: Spro_1079
gene_biotype: protein_coding
description:
  PFAM: Polyprenyl synthetase; KEGG: yen:YE3154 geranyltranstransferase; Belongs to the FPP/GGPP synthase family.


ensembl_gene_id: Spro_1080
symbol: xseB
gene_biotype: protein_coding
description:
  Exodeoxyribonuclease VII, small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family.


ensembl_gene_id: Spro_1081
symbol: thiI
gene_biotype: protein_coding
description:
  Thiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.


ensembl_gene_id: Spro_1082
symbol: Spro_1082
gene_biotype: protein_coding
description:
  TIGRFAM: DJ-1 family protein; PFAM: ThiJ/PfpI domain protein; KEGG: eca:ECA1135 4-methyl-5b-hydroxyethyl)-thiazole monophosphate biosynthesis protein.


ensembl_gene_id: Spro_1083
symbol: Spro_1083
gene_biotype: protein_coding
description:
  2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.


ensembl_gene_id: Spro_1084
symbol: Spro_1084
gene_biotype: protein_coding
description:
  PFAM: protein of unknown function DUF520; KEGG: yen:YE3147 hypothetical protein; Belongs to the UPF0234 family.


ensembl_gene_id: Spro_1085
symbol: Spro_1085
gene_biotype: protein_coding
description:
  PFAM: General substrate transporter; major facilitator superfamily MFS_1; KEGG: yen:YE3146 putative transporter.


ensembl_gene_id: Spro_1086
symbol: cyoE
gene_biotype: protein_coding
description:
  Protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.


ensembl_gene_id: Spro_1087
symbol: Spro_1087
gene_biotype: protein_coding
description:
  TIGRFAM: Cytochrome o ubiquinol oxidase subunit IV; PFAM: cytochrome C oxidase subunit IV; KEGG: ypi:YpsIP31758_3101 cytochrome o ubiquinol oxidase, subunit IV.


ensembl_gene_id: Spro_1088
symbol: Spro_1088
gene_biotype: protein_coding
description:
  TIGRFAM: Cytochrome o ubiquinol oxidase subunit III; PFAM: cytochrome c oxidase subunit III; KEGG: yen:YE3143 cytochrome o ubiquinol oxidase subunit III.


ensembl_gene_id: Spro_1089
symbol: Spro_1089
gene_biotype: protein_coding
description:
  KEGG: yen:YE3142 cytochrome o ubiquinol oxidase subunit I; TIGRFAM: Cytochrome o ubiquinol oxidase subunit I; PFAM: cytochrome c oxidase subunit I; Belongs to the heme-copper respiratory oxidase family.


ensembl_gene_id: Spro_1090
symbol: Spro_1090
gene_biotype: protein_coding
description:
  TIGRFAM: ubiquinol oxidase, subunit II; PFAM: cytochrome c oxidase subunit II; COX aromatic rich domain protein; KEGG: yen:YE3141 cytochrome o ubiquinol oxidase subunit II.


ensembl_gene_id: Spro_1091
symbol: Spro_1091
gene_biotype: protein_coding
description:
  TIGRFAM: AmpG-related permease; PFAM: major facilitator superfamily MFS_1; KEGG: yen:YE3139 beta-lactamase induction signal transducer AmpG.


ensembl_gene_id: Spro_1093
symbol: Spro_1093
gene_biotype: protein_coding
description:
  PFAM: BolA family protein; KEGG: kpn:KPN_00397 possible regulator of murein genes; Belongs to the BolA/IbaG family.


ensembl_gene_id: Spro_1094
symbol: tig
gene_biotype: protein_coding
description:
  Trigger factor; Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belongs to the FKBP-type PPIase family. Tig subfamily.


ensembl_gene_id: Spro_1095
symbol: clpP
gene_biotype: protein_coding
description:
  ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.


ensembl_gene_id: Spro_1096
symbol: clpX
gene_biotype: protein_coding
description:
  ATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.


ensembl_gene_id: Spro_1097
symbol: lon
gene_biotype: protein_coding
description:
  ATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.


ensembl_gene_id: Spro_1099
symbol: Spro_1099
gene_biotype: protein_coding
description:
  PFAM: PpiC-type peptidyl-prolyl cis-trans isomerase; KEGG: yen:YE3130 peptidyl-prolyl cis-trans isomerase D.


ensembl_gene_id: Spro_1100
symbol: Spro_1100
gene_biotype: protein_coding
description:
  TIGRFAM: competence protein ComEA helix-hairpin-helix repeat protein; KEGG: eca:ECA1153 hypothetical protein.


ensembl_gene_id: Spro_1102
symbol: queC
gene_biotype: protein_coding
description:
  exsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family.


ensembl_gene_id: Spro_1104
symbol: cof
gene_biotype: protein_coding
description:
  Cof-like hydrolase; Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2-methyl-5- hydroxymethylpyrimidine phosphate (HMP-P).


ensembl_gene_id: Spro_1105
symbol: Spro_1105
gene_biotype: protein_coding
description:
  PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: yen:YE3124 putative pyridoxal-phosphate dependent protein.


ensembl_gene_id: Spro_1107
symbol: Spro_1107
gene_biotype: protein_coding
description:
  ABC transporter-related protein; PFAM: ABC transporter transmembrane region; ABC transporter related; SMART: AAA ATPase; KEGG: yen:YE3122 probable ABC transporter (ATP-binding protein).


ensembl_gene_id: Spro_1108
symbol: Spro_1108
gene_biotype: protein_coding
description:
  ABC transporter-related protein; PFAM: ABC transporter transmembrane region; ABC transporter related; SMART: AAA ATPase; KEGG: yen:YE3121 probable ATP transporter (ATP-binding protein).


ensembl_gene_id: Spro_1109
symbol: Spro_1109
gene_biotype: protein_coding
description:
  PFAM: nitrogen regulatory protein P-II; KEGG: yen:YE3120 nitrogen regulatory protein P-II; Belongs to the P(II) protein family.


ensembl_gene_id: Spro_1110
symbol: Spro_1110
gene_biotype: protein_coding
description:
  TIGRFAM: ammonium transporter; PFAM: Rh family protein/ammonium transporter; KEGG: yen:YE3119 probable ammonium transporter.


ensembl_gene_id: Spro_1111
symbol: Spro_1111
gene_biotype: protein_coding
description:
  KEGG: yps:YPTB0975 acyl-CoA thioesterase II; TIGRFAM: acyl-CoA thioesterase II; PFAM: acyl-CoA thioesterase.


ensembl_gene_id: Spro_1113
symbol: Spro_1113
gene_biotype: protein_coding
description:
  TIGRFAM: methylated-DNA--protein-cysteine methyltransferase; PFAM: Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding; KEGG: yen:YE3116 putative 6-O-methylguanine DNA methyltransferase family protein.


ensembl_gene_id: Spro_1115
symbol: Spro_1115
gene_biotype: protein_coding
description:
  PFAM: Xanthine/uracil/vitamin C permease; sulphate transporter; KEGG: kpn:KPN_02555 putative xanthine/uracil/vitamin C permease.


ensembl_gene_id: Spro_1117
symbol: Spro_1117
gene_biotype: protein_coding
description:
  Transcriptional regulator, LysR family; PFAM: regulatory protein LysR; LysR substrate-binding; KEGG: kpn:KPN_02553 putative transcriptional regulator (LysR family).


ensembl_gene_id: Spro_1118
symbol: Spro_1118
gene_biotype: protein_coding
description:
  PFAM: Haemolysin expression modulating family protein; KEGG: eca:ECA1165 haemolysin expression modulating protein.


ensembl_gene_id: Spro_1121
symbol: Spro_1121
gene_biotype: protein_coding
description:
  ABC transporter-related protein; PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: yen:YE3111 ABC transport system ATP-binding protein.


ensembl_gene_id: Spro_1123
symbol: Spro_1123
gene_biotype: protein_coding
description:
  PFAM: periplasmic solute binding protein; KEGG: yen:YE3109 periplasmic solute binding protein; Belongs to the bacterial solute-binding protein 9 family.


ensembl_gene_id: Spro_1124
symbol: rpmJ
gene_biotype: protein_coding
description:
  PFAM: ribosomal protein L36; KEGG: stm:STM0470 putative 50S ribosomal protein L36 (second copy); Belongs to the bacterial ribosomal protein bL36 family.


ensembl_gene_id: Spro_1126
symbol: Spro_1126
gene_biotype: protein_coding
description:
  TIGRFAM: transporter, hydrophobe/amphiphile efflux-1 (HAE1) family; PFAM: acriflavin resistance protein; KEGG: yen:YE3101 multidrug efflux protein.


ensembl_gene_id: Spro_1127
symbol: Spro_1127
gene_biotype: protein_coding
description:
  TIGRFAM: efflux transporter, RND family, MFP subunit; PFAM: secretion protein HlyD family protein; KEGG: yen:YE3100 multidrug efflux protein; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.


ensembl_gene_id: Spro_1128
symbol: Spro_1128
gene_biotype: protein_coding
description:
  PFAM: regulatory protein TetR; Tetracycline transcriptional repressor MAATS-type domain protein; KEGG: yen:YE3099 putative TetR-family transcriptional regulatory protein.


ensembl_gene_id: Spro_1132
symbol: Spro_1132
gene_biotype: protein_coding
description:
  PFAM: Primosomal replication priB and priC; KEGG: ypi:YpsIP31758_3062 primosomal replication protein N''.


ensembl_gene_id: Spro_1134
symbol: apt
gene_biotype: protein_coding
description:
  Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.


ensembl_gene_id: Spro_1135
symbol: dnaX
gene_biotype: protein_coding
description:
  DNA polymerase III, subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.


ensembl_gene_id: Spro_1136
symbol: Spro_1136
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.


ensembl_gene_id: Spro_1137
symbol: recR
gene_biotype: protein_coding
description:
  Recombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.


ensembl_gene_id: Spro_1139
symbol: adk
gene_biotype: protein_coding
description:
  Nucleoside-triphosphate--adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.


ensembl_gene_id: Spro_1140
symbol: Spro_1140
gene_biotype: protein_coding
description:
  Transcriptional regulator, CdaR; PFAM: sugar diacid recognition domain protein; KEGG: sec:SC2489 putative regulatory protein.


ensembl_gene_id: Spro_1142
symbol: Spro_1142
gene_biotype: protein_coding
description:
  PFAM: glycerate kinase; KEGG: ypi:YpsIP31758_4052 glycerate kinase; Belongs to the glycerate kinase type-1 family.


ensembl_gene_id: Spro_1143
symbol: hemH
gene_biotype: protein_coding
description:
  Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.


ensembl_gene_id: Spro_1145
symbol: Spro_1145
gene_biotype: protein_coding
description:
  TIGRFAM: potassium efflux system protein; PFAM: TrkA-N domain protein; sodium/hydrogen exchanger; KEGG: yen:YE3068 putative potassium antiporter; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family.


ensembl_gene_id: Spro_1147
symbol: Spro_1147
gene_biotype: protein_coding
description:
  PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; KEGG: yen:YE3066 UDP-sugar hydrolase; Belongs to the 5'-nucleotidase family.


ensembl_gene_id: Spro_1148
symbol: Spro_1148
gene_biotype: protein_coding
description:
  TIGRFAM: ybaK/ebsC protein; PFAM: YbaK/prolyl-tRNA synthetase associated region; KEGG: yen:YE3063 hypothetical protein; Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily.


ensembl_gene_id: Spro_1150
symbol: Spro_1150
gene_biotype: protein_coding
description:
  PFAM: Heavy metal transport/detoxification protein; KEGG: yen:YE3061 putative cation-transporting ATPase.


ensembl_gene_id: Spro_1151
symbol: Spro_1151
gene_biotype: protein_coding
description:
  Transcriptional regulator, MerR family; TIGRFAM: Cu(I)-responsive transcriptional regulator; PFAM: regulatory protein MerR; Transcription regulator MerR DNA binding; KEGG: yen:YE3060 putative regulatory protein.


ensembl_gene_id: Spro_1154
symbol: Spro_1154
gene_biotype: protein_coding
description:
  PFAM: Cyclopropane-fatty-acyl-phospholipid synthase; Methyltransferase type 11; Methyltransferase type 12; KEGG: sdy:SDY_1887 cyclopropane fatty acyl phospholipid synthase.


ensembl_gene_id: Spro_1156
symbol: Spro_1156
gene_biotype: protein_coding
description:
  PFAM: short-chain dehydrogenase/reductase SDR; KR domain protein; KEGG: yen:YE3056 probable short-chain dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family.


ensembl_gene_id: Spro_1157
symbol: Spro_1157
gene_biotype: protein_coding
description:
  Lysophospholipase; PFAM: lipolytic protein G-D-S-L family; KEGG: ypi:YpsIP31758_3021 GDSL-like lipase/acylhydrolase family protein.


ensembl_gene_id: Spro_1158
symbol: Spro_1158
gene_biotype: protein_coding
description:
  ABC transporter-related protein; PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: ypp:YPDSF_2717 ABC transporter ATP-binding protein.


ensembl_gene_id: Spro_1160
symbol: Spro_1160
gene_biotype: protein_coding
description:
  KEGG: ent:Ent638_3347 sugar transporter; TIGRFAM: sugar transporter; PFAM: General substrate transporter; major facilitator superfamily MFS_1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.


ensembl_gene_id: Spro_1161
symbol: Spro_1161
gene_biotype: protein_coding
description:
  TIGRFAM: UDP-glucose 4-epimerase; PFAM: NAD-dependent epimerase/dehydratase; short-chain dehydrogenase/reductase SDR; 3-beta hydroxysteroid dehydrogenase/isomerase; polysaccharide biosynthesis protein CapD; dTDP-4-dehydrorhamnose reductase; Male sterility domain; KR domain protein; KEGG: plu:plu4831 UDP-glucose 4-epimerase (galactowaldenase) (UDP-galactose 4-epimerase).


ensembl_gene_id: Spro_1162
symbol: purK
gene_biotype: protein_coding
description:
  Phosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).


ensembl_gene_id: Spro_1163
symbol: purE
gene_biotype: protein_coding
description:
  Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).


ensembl_gene_id: Spro_1164
symbol: lpxH
gene_biotype: protein_coding
description:
  UDP-2,3-diacylglucosamine hydrolase; Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.


ensembl_gene_id: Spro_1165
symbol: Spro_1165
gene_biotype: protein_coding
description:
  Peptidyl-prolyl cis-trans isomerase cyclophilin type; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.


ensembl_gene_id: Spro_1166
symbol: cysS
gene_biotype: protein_coding
description:
  KEGG: ypi:YpsIP31758_3014 cysteinyl-tRNA synthetase; TIGRFAM: cysteinyl-tRNA synthetase; PFAM: Cysteinyl-tRNA synthetase class Ia DALR; tRNA synthetase class I (M); Cysteinyl-tRNA synthetase class Ia; Belongs to the class-I aminoacyl-tRNA synthetase family.


ensembl_gene_id: Spro_1168
symbol: folD
gene_biotype: protein_coding
description:
  Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.


ensembl_gene_id: Spro_1170
symbol: Spro_1170
gene_biotype: protein_coding
description:
  PFAM: Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KEGG: ret:RHE_PD00126 probable aryl-alcohol dehydrogenase protein.


ensembl_gene_id: Spro_1172
symbol: Spro_1172
gene_biotype: protein_coding
description:
  PFAM: NADH:flavin oxidoreductase/NADH oxidase; KEGG: pfo:Pfl_2479 NADH:flavin oxidoreductase/NADH oxidase.


ensembl_gene_id: Spro_1173
symbol: Spro_1173
gene_biotype: protein_coding
description:
  PFAM: Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KEGG: bur:Bcep18194_B1199 zinc-containing alcohol dehydrogenase superfamily.


ensembl_gene_id: Spro_1176
symbol: Spro_1176
gene_biotype: protein_coding
description:
  Transcriptional regulator, AraC family; PFAM: helix-turn-helix- domain containing protein AraC type; KEGG: bur:Bcep18194_B1198 transcriptional regulator, AraC family.


ensembl_gene_id: Spro_1179
symbol: Spro_1179
gene_biotype: protein_coding
description:
  Transcriptional regulator, LysR family; PFAM: regulatory protein LysR; LysR substrate-binding; KEGG: mlo:mll1582 probable transcriptional regulator.


ensembl_gene_id: Spro_1181
symbol: Spro_1181
gene_biotype: protein_coding
description:
  TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; MASE1 domain protein; KEGG: pen:PSEEN2260 diguanylate cyclase (GGDEF) domain.


ensembl_gene_id: Spro_1184
symbol: Spro_1184
gene_biotype: protein_coding
description:
  ABC transporter-related protein; PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: eca:ECA2153 ABC transporter, ATP-binding protein.


ensembl_gene_id: Spro_1185
symbol: Spro_1185
gene_biotype: protein_coding
description:
  TIGRFAM: polar amino acid ABC transporter, inner membrane subunit; PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: eca:ECA2154 putative ABC transporter, permease.


ensembl_gene_id: Spro_1188
symbol: Spro_1188
gene_biotype: protein_coding
description:
  Amidohydrolase; KEGG: eca:ECA2160 putative peptidase; TIGRFAM: amidohydrolase; PFAM: peptidase M20; peptidase dimerisation domain protein.


ensembl_gene_id: Spro_1189
symbol: Spro_1189
gene_biotype: protein_coding
description:
  PFAM: Cold-shock protein DNA-binding; SMART: Cold shock protein; KEGG: ypi:YpsIP31758_2958 cold shock DNA-binding domain protein.


ensembl_gene_id: Spro_1190
symbol: Spro_1190
gene_biotype: protein_coding
description:
  TIGRFAM: drug resistance transporter, Bcr/CflA subfamily; PFAM: major facilitator superfamily MFS_1; KEGG: bld:BLi04103 putative bicyclomycin resistance protein.


ensembl_gene_id: Spro_1191
symbol: Spro_1191
gene_biotype: protein_coding
description:
  Transcriptional regulator, TetR family; PFAM: regulatory protein TetR; KEGG: ecs:ECs1862 putative transcription regulatory protein.


ensembl_gene_id: Spro_1192
symbol: crcB
gene_biotype: protein_coding
description:
  CrcB protein; Important for reducing fluoride concentration in the cell, thus reducing its toxicity; Belongs to the CrcB (TC 9.B.71) family.


ensembl_gene_id: Spro_1193
symbol: Spro_1193
gene_biotype: protein_coding
description:
  TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; MASE2 domain protein; KEGG: yen:YE3010 putative diguanylate cyclase/phosphodiesterase domain 1 protein.


ensembl_gene_id: Spro_1194
symbol: tatE
gene_biotype: protein_coding
description:
  Twin-arginine translocation protein, TatA/E family subunit; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA; Belongs to the TatA/E family. TatE subfamily.


ensembl_gene_id: Spro_1195
symbol: lipA
gene_biotype: protein_coding
description:
  Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.


ensembl_gene_id: Spro_1196
symbol: lipB
gene_biotype: protein_coding
description:
  Lipoate-protein ligase B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.


ensembl_gene_id: Spro_1197
symbol: Spro_1197
gene_biotype: protein_coding
description:
  PFAM: protein of unknown function DUF493; KEGG: sgl:SG0794 hypothetical protein; Belongs to the UPF0250 family.


ensembl_gene_id: Spro_1198
symbol: Spro_1198
gene_biotype: protein_coding
description:
  Serine-type D-Ala-D-Ala carboxypeptidase; PFAM: beta-lactamase; peptidase S11 D-alanyl-D-alanine carboxypeptidase 1; Penicillin-binding protein 5 domain protein; KEGG: yen:YE3005 putative penicillin-binding protein 5; Belongs to the peptidase S11 family.


ensembl_gene_id: Spro_1199
symbol: rlpA
gene_biotype: protein_coding
description:
  Rare lipoprotein A; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.


ensembl_gene_id: Spro_1200
symbol: mrdB
gene_biotype: protein_coding
description:
  Rod shape-determining protein RodA; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily.


ensembl_gene_id: Spro_1201
symbol: mrdA
gene_biotype: protein_coding
description:
  Peptidoglycan glycosyltransferase; Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily.


ensembl_gene_id: Spro_1202
symbol: rlmH
gene_biotype: protein_coding
description:
  Protein of unknown function DUF163; Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA; Belongs to the RNA methyltransferase RlmH family.


ensembl_gene_id: Spro_1203
symbol: rsfS
gene_biotype: protein_coding
description:
  Iojap-like protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.


ensembl_gene_id: Spro_1204
symbol: nadD
gene_biotype: protein_coding
description:
  Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).


ensembl_gene_id: Spro_1205
symbol: Spro_1205
gene_biotype: protein_coding
description:
  KEGG: yps:YPTB1101 DNA polymerase III, delta subunit; TIGRFAM: DNA polymerase III, delta subunit; PFAM: DNA polymerase III delta.


ensembl_gene_id: Spro_1206
symbol: lptE
gene_biotype: protein_coding
description:
  Rare lipoprotein B; Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane.


ensembl_gene_id: Spro_1207
symbol: leuS
gene_biotype: protein_coding
description:
  TIGRFAM: leucyl-tRNA synthetase; KEGG: ypi:YpsIP31758_2926 leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.


ensembl_gene_id: Spro_1209
symbol: azoR
gene_biotype: protein_coding
description:
  NAD(P)H dehydrogenase (quinone); Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity; Belongs to the azoreductase type 1 family.


ensembl_gene_id: Spro_1210
symbol: Spro_1210
gene_biotype: protein_coding
description:
  PFAM: Inosine/uridine-preferring nucleoside hydrolase; KEGG: spt:SPA2079 probable nucleoside hydrolase; Belongs to the IUNH family.


ensembl_gene_id: Spro_1211
symbol: Spro_1211
gene_biotype: protein_coding
description:
  ABC transporter-related protein; PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: yen:YE2994 putative glutamate/aspartate transport ATP-binding protein.


ensembl_gene_id: Spro_1212
symbol: Spro_1212
gene_biotype: protein_coding
description:
  TIGRFAM: polar amino acid ABC transporter, inner membrane subunit; PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: eca:ECA1312 glutamate/aspartate transport system permease protein.


ensembl_gene_id: Spro_1213
symbol: Spro_1213
gene_biotype: protein_coding
description:
  TIGRFAM: polar amino acid ABC transporter, inner membrane subunit; PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: yen:YE2992 putative glutamate/aspartate transport system permease.


ensembl_gene_id: Spro_1214
symbol: Spro_1214
gene_biotype: protein_coding
description:
  PFAM: extracellular solute-binding protein family 3; KEGG: yen:YE2991 putative amino acid-binding protein precursor.


ensembl_gene_id: Spro_1215
symbol: lnt
gene_biotype: protein_coding
description:
  Apolipoprotein N-acyltransferase; Catalyzes the phospholipid dependent N-acylation of the N- terminal cysteine of apolipoprotein, the last step in lipoprotein maturation; Belongs to the CN hydrolase family. Apolipoprotein N- acyltransferase subfamily.


ensembl_gene_id: Spro_1216
symbol: Spro_1216
gene_biotype: protein_coding
description:
  Transporter-associated region; PFAM: CBS domain containing protein; transporter-associated region; KEGG: yen:YE2988 hypothetical protein.


ensembl_gene_id: Spro_1217
symbol: ybeY
gene_biotype: protein_coding
description:
  Protein of unknown function UPF0054; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.


ensembl_gene_id: Spro_1219
symbol: Spro_1219
gene_biotype: protein_coding
description:
  TIGRFAM: alkylphosphonate utilization operon protein PhnA; PFAM: PhnA protein; KEGG: stm:STM4289 putative alkylphosphonate uptake protein in phosphonate metabolism.


ensembl_gene_id: Spro_1220
symbol: miaB
gene_biotype: protein_coding
description:
  tRNA-i(6)A37 thiotransferase enzyme MiaB; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.


ensembl_gene_id: Spro_1221
symbol: Spro_1221
gene_biotype: protein_coding
description:
  TIGRFAM: Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; PFAM: monooxygenase FAD-binding; FAD dependent oxidoreductase; KEGG: yen:YE2984 putative 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase.


ensembl_gene_id: Spro_1222
symbol: Spro_1222
gene_biotype: protein_coding
description:
  TIGRFAM: asparagine synthase (glutamine-hydrolyzing); PFAM: glutamine amidotransferase class-II; asparagine synthase; KEGG: kpn:KPN_00695 asparagine synthetase B.


ensembl_gene_id: Spro_1223
symbol: Spro_1223
gene_biotype: protein_coding
description:
  PFAM: glycoside hydrolase family 18; Carbohydrate-binding family V/XII; Fibronectin type III domain protein; KEGG: pfl:PFL_2091 chitinase; Belongs to the glycosyl hydrolase 18 family.


ensembl_gene_id: Spro_1224
symbol: Spro_1224
gene_biotype: protein_coding
description:
  TIGRFAM: HAD-superfamily hydrolase, subfamily IIA; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: yen:YE2982 putative N-acetylglucosamine metabolism protein.


ensembl_gene_id: Spro_1226
symbol: Spro_1226
gene_biotype: protein_coding
description:
  KEGG: yen:YE2980 putative N-acetylglucosamine-6-phosphate deacetylase; TIGRFAM: N-acetylglucosamine-6-phosphate deacetylase; PFAM: amidohydrolase.


ensembl_gene_id: Spro_1227
symbol: nagB
gene_biotype: protein_coding
description:
  Glucosamine-6-phosphate isomerase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.


ensembl_gene_id: Spro_1228
symbol: Spro_1228
gene_biotype: protein_coding
description:
  TIGRFAM: PTS system, glucose subfamily, IIA subunit; PTS system, N-acetylglucosamine-specific IIBC subunit; PTS system, glucose-like IIB subunint; PFAM: sugar-specific permease EIIA 1 domain; phosphotransferase system PTS EIIB protein; phosphotransferase system EIIC; KEGG: stm:STM0685 Sugar Specific PTS family, n-acetylglucosamine-specific enzyme IIABC.


ensembl_gene_id: Spro_1229
symbol: glnS
gene_biotype: protein_coding
description:
  TIGRFAM: glutaminyl-tRNA synthetase; PFAM: glutamyl-tRNA synthetase class Ic; KEGG: yen:YE2977 glutaminyl-tRNA synthetase.


ensembl_gene_id: Spro_1232
symbol: Spro_1232
gene_biotype: protein_coding
description:
  Beta-N-acetylhexosaminidase; PFAM: Carbohydrate-binding chitobiase/hexosaminidase-type domain protein; glycoside hydrolase family 20 domain protein; Beta-N-acetylhexosaminidase-like; Glycoside hydrolase, family 20, catalytic core; KEGG: yen:YE2974 chitobiase precursor.


ensembl_gene_id: Spro_1234
symbol: Spro_1234
gene_biotype: protein_coding
description:
  TIGRFAM: UDP-glucose 4-epimerase; PFAM: NAD-dependent epimerase/dehydratase; short-chain dehydrogenase/reductase SDR; 3-beta hydroxysteroid dehydrogenase/isomerase; polysaccharide biosynthesis protein CapD; dTDP-4-dehydrorhamnose reductase; Male sterility domain; KEGG: plu:plu4831 UDP-glucose 4-epimerase (galactowaldenase) (UDP-galactose 4-epimerase).


ensembl_gene_id: Spro_1236
symbol: fur
gene_biotype: protein_coding
description:
  Ferric uptake regulator, Fur family; PFAM: ferric-uptake regulator; KEGG: sgl:SG0861 ferric uptake regulation protein; Belongs to the Fur family.


ensembl_gene_id: Spro_1237
symbol: Spro_1237
gene_biotype: protein_coding
description:
  Flavodoxin; Low-potential electron donor to a number of redox enzymes. Belongs to the flavodoxin family.


ensembl_gene_id: Spro_1238
symbol: Spro_1238
gene_biotype: protein_coding
description:
  PFAM: CopG domain protein DNA-binding domain protein; KEGG: ypi:YpsIP31758_2899 transcriptional regulator, CopG family.


ensembl_gene_id: Spro_1240
symbol: seqA
gene_biotype: protein_coding
description:
  SeqA family protein; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated.


ensembl_gene_id: Spro_1241
symbol: Spro_1241
gene_biotype: protein_coding
description:
  TIGRFAM: phosphoglucomutase, alpha-D-glucose phosphate-specific; PFAM: phosphoglucomutase/phosphomannomutase; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III; KEGG: yen:YE2967 phosphoglucomutase.


ensembl_gene_id: Spro_1242
symbol: Spro_1242
gene_biotype: protein_coding
description:
  PFAM: transcriptional regulator PadR family protein; KEGG: ypi:YpsIP31758_0905 transcriptional regulator, PadR family.


ensembl_gene_id: Spro_1244
symbol: Spro_1244
gene_biotype: protein_coding
description:
  Two component transcriptional regulator, winged helix family; PFAM: response regulator receiver; transcriptional regulator domain protein; KEGG: eca:ECA1338 two-component response regulator of kdp operon.


ensembl_gene_id: Spro_1245
symbol: Spro_1245
gene_biotype: protein_coding
description:
  PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; Osmosensitive K channel His kinase sensor; UspA domain protein; KEGG: yen:YE2963 two-component regulatory protein sensor kinase KdpD.


ensembl_gene_id: Spro_1246
symbol: kdpC
gene_biotype: protein_coding
description:
  Potassium-transporting ATPase, C subunit; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.


ensembl_gene_id: Spro_1247
symbol: kdpB
gene_biotype: protein_coding
description:
  K+-transporting ATPase, B subunit; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.


ensembl_gene_id: Spro_1248
symbol: kdpA
gene_biotype: protein_coding
description:
  Potassium-transporting ATPase, A subunit; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane.


ensembl_gene_id: Spro_1251
symbol: Spro_1251
gene_biotype: protein_coding
description:
  PFAM: protein of unknown function DUF523; Protein of unknown function DUF1722; KEGG: eca:ECA1348 hypothetical protein.


ensembl_gene_id: Spro_1252
symbol: Spro_1252
gene_biotype: protein_coding
description:
  Deoxyribodipyrimidine photo-lyase; PFAM: DNA photolyase FAD-binding; DNA photolyase domain protein; KEGG: yen:YE2957 putative deoxyribodipyrimidine photolyase.


ensembl_gene_id: Spro_1253
symbol: Spro_1253
gene_biotype: protein_coding
description:
  PFAM: cyclic-AMP phosphodiesterase class-II; KEGG: yen:YE2956 putative 3',5'-cyclic-nucleotide phosphodiesterase.


ensembl_gene_id: Spro_1256
symbol: Spro_1256
gene_biotype: protein_coding
description:
  TIGRFAM: urea amidolyase related protein; PFAM: Allophanate hydrolase subunit 2; KEGG: yps:YPTB2909 hypothetical protein.


ensembl_gene_id: Spro_1257
symbol: pxpA
gene_biotype: protein_coding
description:
  LamB/YcsF family protein; Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.


ensembl_gene_id: Spro_1260
symbol: pcp
gene_biotype: protein_coding
description:
  Pyrrolidone-carboxylate peptidase; Removes 5-oxoproline from various penultimate amino acid residues except L-proline; Belongs to the peptidase C15 family.


ensembl_gene_id: Spro_1261
symbol: nei
gene_biotype: protein_coding
description:
  DNA-(apurinic or apyrimidinic site) lyase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.


ensembl_gene_id: Spro_1262
symbol: Spro_1262
gene_biotype: protein_coding
description:
  KEGG: yen:YE2949 citrate synthase GltA; TIGRFAM: citrate synthase I; PFAM: Citrate synthase; Belongs to the citrate synthase family.


ensembl_gene_id: Spro_1263
symbol: Spro_1263
gene_biotype: protein_coding
description:
  TIGRFAM: Succinate dehydrogenase cytochrome b556 subunit; PFAM: succinate dehydrogenase cytochrome b subunit; KEGG: yps:YPTB1143 succinate dehydrogenase cytochrome b-556 subunit.


ensembl_gene_id: Spro_1264
symbol: Spro_1264
gene_biotype: protein_coding
description:
  Succinate dehydrogenase hydrophobic membrane anchor; Membrane-anchoring subunit of succinate dehydrogenase (SDH).


ensembl_gene_id: Spro_1265
symbol: Spro_1265
gene_biotype: protein_coding
description:
  KEGG: yen:YE2946 succinate dehydrogenase flavoprotein subunit; TIGRFAM: succinate dehydrogenase, flavoprotein subunit; succinate dehydrogenase or fumarate reductase, flavoprotein subunit; PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.


ensembl_gene_id: Spro_1266
symbol: Spro_1266
gene_biotype: protein_coding
description:
  KEGG: ypi:YpsIP31758_2882 succinate dehydrogenase, iron-sulfur protein; TIGRFAM: succinate dehydrogenase and fumarate reductase iron-sulfur protein; PFAM: ferredoxin; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.


ensembl_gene_id: Spro_1267
symbol: Spro_1267
gene_biotype: protein_coding
description:
  KEGG: ypi:YpsIP31758_2881 2-oxoglutarate dehydrogenase, E1 component; TIGRFAM: 2-oxoglutarate dehydrogenase, E1 subunit; PFAM: dehydrogenase E1 component; Transketolase central region.


ensembl_gene_id: Spro_1268
symbol: Spro_1268
gene_biotype: protein_coding
description:
  2-oxoglutarate dehydrogenase, E2 subunit, dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2).


ensembl_gene_id: Spro_1269
symbol: sucC
gene_biotype: protein_coding
description:
  succinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.


ensembl_gene_id: Spro_1270
symbol: sucD
gene_biotype: protein_coding
description:
  succinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.


ensembl_gene_id: Spro_1271
symbol: Spro_1271
gene_biotype: protein_coding
description:
  PFAM: cytochrome bd ubiquinol oxidase subunit I; KEGG: eca:ECA1365 cytochrome D ubiquinol oxidase subunit I.


ensembl_gene_id: Spro_1272
symbol: Spro_1272
gene_biotype: protein_coding
description:
  KEGG: yen:YE2938 cytochrome d ubiquinol oxidase subunit II; TIGRFAM: cytochrome d ubiquinol oxidase, subunit II; PFAM: cytochrome bd ubiquinol oxidase subunit II.


ensembl_gene_id: Spro_1273
symbol: Spro_1273
gene_biotype: protein_coding
description:
  TIGRFAM: cyd operon protein YbgT; PFAM: membrane bound YbgT family protein; KEGG: sdy:SDY_0682 putative outer membrane lipoprotein.


ensembl_gene_id: Spro_1274
symbol: Spro_1274
gene_biotype: protein_coding
description:
  TIGRFAM: cyd operon protein YbgE; PFAM: Cyd operon protein YbgE; KEGG: eca:ECA1368 hypothetical protein.


ensembl_gene_id: Spro_1275
symbol: Spro_1275
gene_biotype: protein_coding
description:
  TIGRFAM: Pol-Pal system-associated acyl-CoA thioesterase; PFAM: thioesterase superfamily protein; KEGG: yen:YE2936 hypothetical protein.


ensembl_gene_id: Spro_1276
symbol: tolQ
gene_biotype: protein_coding
description:
  Tol-Pal system TolQ; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. Required, with TolR, for the proton motive force-dependent activation of TolA and for TolA-Pal interaction.


ensembl_gene_id: Spro_1277
symbol: tolR
gene_biotype: protein_coding
description:
  Biopolymer transport TolR; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. Required, with TolQ, for the proton motive force-dependent activation of TolA and for TolA-Pal interaction.


ensembl_gene_id: Spro_1278
symbol: Spro_1278
gene_biotype: protein_coding
description:
  TIGRFAM: Tol-Pal system TolA; PFAM: TolA family protein; KEGG: ypm:YP_1033 TolA colicin import membrane protein.


ensembl_gene_id: Spro_1279
symbol: tolB
gene_biotype: protein_coding
description:
  Tol-Pal system beta propeller repeat TolB; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. TolB occupies a key intermediary position in the Tol-Pal system because it communicates directly with both membrane-embedded components, Pal in the outer membrane and TolA in the inner membrane.


ensembl_gene_id: Spro_1280
symbol: pal
gene_biotype: protein_coding
description:
  Peptidoglycan-associated lipoprotein; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.


ensembl_gene_id: Spro_1281
symbol: cpoB
gene_biotype: protein_coding
description:
  Tol-Pal system YbgF; Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division; Belongs to the CpoB family.


ensembl_gene_id: Spro_1282
symbol: nadA
gene_biotype: protein_coding
description:
  Quinolinate synthetase complex, A subunit; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate; Belongs to the quinolinate synthase A family. Type 1 subfamily.


ensembl_gene_id: Spro_1283
symbol: Spro_1283
gene_biotype: protein_coding
description:
  TIGRFAM: nicotinamide mononucleotide transporter PnuC; PFAM: Nicotinamide mononucleotide transporter PnuC; KEGG: yen:YE2927 intergral membrane NMN transport protein PnuC.


ensembl_gene_id: Spro_1284
symbol: Spro_1284
gene_biotype: protein_coding
description:
  TIGRFAM: cation diffusion facilitator family transporter; PFAM: cation efflux protein; KEGG: ypi:YpsIP31758_2863 zinc transporter ZitB.


ensembl_gene_id: Spro_1285
symbol: Spro_1285
gene_biotype: protein_coding
description:
  Hpt sensor hybrid histidine kinase; PFAM: response regulator receiver; ATP-binding region ATPase domain protein; histidine kinase A domain protein; Hpt domain protein; SMART: extracellular solute-binding protein family 3; KEGG: pfo:Pfl_1864 Hpt sensor hybrid histidine kinase.


ensembl_gene_id: Spro_1286
symbol: Spro_1286
gene_biotype: protein_coding
description:
  Two component transcriptional regulator, LuxR family; PFAM: regulatory protein LuxR; response regulator receiver; KEGG: pfl:PFL_2955 DNA-binding response regulator, LuxR family.


ensembl_gene_id: Spro_1288
symbol: gpmA
gene_biotype: protein_coding
description:
  Phosphoglycerate mutase 1 family; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily.


ensembl_gene_id: Spro_1291
symbol: galK
gene_biotype: protein_coding
description:
  Galactokinase; Catalyzes the transfer of the gamma-phosphate of ATP to D- galactose to form alpha-D-galactose-1-phosphate (Gal-1-P). Belongs to the GHMP kinase family. GalK subfamily.


ensembl_gene_id: Spro_1292
symbol: Spro_1292
gene_biotype: protein_coding
description:
  KEGG: kpn:KPN_00772 galactose-1-phosphate uridylyltransferase; TIGRFAM: galactose-1-phosphate uridylyltransferase; PFAM: galactose-1-phosphate uridyl transferase domain protein.


ensembl_gene_id: Spro_1293
symbol: Spro_1293
gene_biotype: protein_coding
description:
  PFAM: Abortive infection protein; KEGG: ypi:YpsIP31758_2854 CAAX amino terminal protease family protein.


ensembl_gene_id: Spro_1295
symbol: Spro_1295
gene_biotype: protein_coding
description:
  ABC transporter-related protein; PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: yen:YE2915 putative molybdenum transport ATP-binding protein ModF.


ensembl_gene_id: Spro_1296
symbol: Spro_1296
gene_biotype: protein_coding
description:
  Transcriptional regulator, ModE family; TIGRFAM: molybdate transport repressor, ModE; PFAM: regulatory protein LysR; TOBE domain protein; KEGG: ypi:YpsIP31758_2852 transcriptional regulator ModE.


ensembl_gene_id: Spro_1297
symbol: Spro_1297
gene_biotype: protein_coding
description:
  TIGRFAM: TonB-dependent siderophore receptor; PFAM: TonB-dependent receptor; TonB-dependent receptor plug; KEGG: mms:mma_0066 TonB-dependent receptor.


ensembl_gene_id: Spro_1298
symbol: Spro_1298
gene_biotype: protein_coding
description:
  PFAM: periplasmic binding protein; KEGG: msm:MSMEG_4561 ABC Fe3+-siderophores transporter, periplasmic binding protein.


ensembl_gene_id: Spro_1299
symbol: Spro_1299
gene_biotype: protein_coding
description:
  PFAM: Methyltransferase type 11; Methyltransferase type 12; KEGG: pau:PA14_39660 hypothetical protein.


ensembl_gene_id: Spro_1300
symbol: Spro_1300
gene_biotype: protein_coding
description:
  PFAM: transport system permease protein; KEGG: msm:MSMEG_4559 ABC transporter, membrane spanning protein; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.


ensembl_gene_id: Spro_1301
symbol: Spro_1301
gene_biotype: protein_coding
description:
  ABC transporter-related protein; PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: cmi:CMM_0365 putative Fe3+-siderophore ABC transporter, ATPase component.


ensembl_gene_id: Spro_1302
symbol: acrZ
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with a broad substrate specificity. This protein binds to AcrB and is required for efflux of some but not all substrates, suggesting it may influence the specificity of drug export.


ensembl_gene_id: Spro_1303
symbol: Spro_1303
gene_biotype: protein_coding
description:
  TIGRFAM: molybdenum ABC transporter, periplasmic molybdate-binding protein; PFAM: extracellular solute-binding protein family 1; KEGG: ypi:YpsIP31758_2850 molybdate ABC transporter, periplasmic molybdate-binding protein.


ensembl_gene_id: Spro_1304
symbol: Spro_1304
gene_biotype: protein_coding
description:
  Molybdate ABC transporter, inner membrane subunit; Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.


ensembl_gene_id: Spro_1305
symbol: modC
gene_biotype: protein_coding
description:
  Molybdate ABC transporter, ATPase subunit; Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Molybdate importer (TC 3.A.1.8) family.


ensembl_gene_id: Spro_1306
symbol: Spro_1306
gene_biotype: protein_coding
description:
  TIGRFAM: Cof-like hydrolase; HAD-superfamily hydrolase, subfamily IIB; PFAM: Haloacid dehalogenase domain protein hydrolase; sucrose-6F-phosphate phosphohydrolase; Haloacid dehalogenase domain protein hydrolase type 3; KEGG: yen:YE2910 hypothetical protein.


ensembl_gene_id: Spro_1307
symbol: pgl
gene_biotype: protein_coding
description:
  6-phosphogluconolactonase; Catalyzes the hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate.


ensembl_gene_id: Spro_1308
symbol: Spro_1308
gene_biotype: protein_coding
description:
  PFAM: PEBP family protein; KEGG: kpn:KPN_00798 conserved protein, phosphatidylethanolamine-binding domain.


ensembl_gene_id: Spro_1310
symbol: bioA
gene_biotype: protein_coding
description:
  Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.


ensembl_gene_id: Spro_1311
symbol: bioB
gene_biotype: protein_coding
description:
  Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family.


ensembl_gene_id: Spro_1312
symbol: bioF
gene_biotype: protein_coding
description:
  8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.


ensembl_gene_id: Spro_1313
symbol: bioC
gene_biotype: protein_coding
description:
  Biotin biosynthesis protein BioC; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway.


ensembl_gene_id: Spro_1314
symbol: bioD
gene_biotype: protein_coding
description:
  Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. Belongs to the dethiobiotin synthetase family.


ensembl_gene_id: Spro_1316
symbol: Spro_1316
gene_biotype: protein_coding
description:
  ABC transporter-related protein; PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: yen:YE2903 putative amino acid transporter.


ensembl_gene_id: Spro_1317
symbol: uvrB
gene_biotype: protein_coding
description:
  Excinuclease ABC, B subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...]


ensembl_gene_id: Spro_1319
symbol: Spro_1319
gene_biotype: protein_coding
description:
  Protein of unknown function UPF0052 and CofD; Required for morphogenesis under gluconeogenic growth conditions; Belongs to the gluconeogenesis factor family.


ensembl_gene_id: Spro_1320
symbol: moaA
gene_biotype: protein_coding
description:
  Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate.


ensembl_gene_id: Spro_1321
symbol: Spro_1321
gene_biotype: protein_coding
description:
  Molybdenum cofactor biosynthesis protein B; May be involved in the biosynthesis of molybdopterin. Belongs to the MoaB/Mog family.


ensembl_gene_id: Spro_1322
symbol: moaC
gene_biotype: protein_coding
description:
  Molybdenum cofactor biosynthesis protein C; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family.


ensembl_gene_id: Spro_1323
symbol: Spro_1323
gene_biotype: protein_coding
description:
  TIGRFAM: molybdopterin converting factor, subunit 1; PFAM: thiamineS protein; KEGG: ypi:YpsIP31758_2834 molybdopterin converting factor, subunit 1.


ensembl_gene_id: Spro_1324
symbol: Spro_1324
gene_biotype: protein_coding
description:
  PFAM: molybdopterin biosynthesis MoaE protein; KEGG: yen:YE2896 molybdopterin [mpt] converting factor, subunit 2.


ensembl_gene_id: Spro_1325
symbol: Spro_1325
gene_biotype: protein_coding
description:
  PFAM: protein of unknown function UPF0005; KEGG: eca:ECA2812 putative membrane protein; Belongs to the BI1 family.


ensembl_gene_id: Spro_1328
symbol: Spro_1328
gene_biotype: protein_coding
description:
  ABC transporter-related protein; PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: ypi:YpsIP31758_2813 ABC transporter, ATP-binding protein.


ensembl_gene_id: Spro_1330
symbol: Spro_1330
gene_biotype: protein_coding
description:
  PFAM: regulatory protein TetR; Transcriptional regulator TetR; KEGG: ypi:YpsIP31758_2811 transcriptional regulator, TetR family.


ensembl_gene_id: Spro_1331
symbol: rhlE
gene_biotype: protein_coding
description:
  DEAD/DEAH box helicase domain protein; DEAD-box RNA helicase involved in ribosome assembly. Has RNA- dependent ATPase activity and unwinds double-stranded RNA.


ensembl_gene_id: Spro_1332
symbol: Spro_1332
gene_biotype: protein_coding
description:
  PFAM: secretion protein HlyD family protein; KEGG: ppu:PP_1272 multidrug efflux MFS membrane fusion protein, putative.


ensembl_gene_id: Spro_1334
symbol: Spro_1334
gene_biotype: protein_coding
description:
  PFAM: regulatory protein IclR; Transcriptional regulator IclR; KEGG: ftn:FTN_0720 transcriptional regulator, IclR family.


ensembl_gene_id: Spro_1336
symbol: Spro_1336
gene_biotype: protein_coding
description:
  PFAM: D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; KEGG: sco:SCO2696 2-hydroxyacid-family dehydrogenase.


ensembl_gene_id: Spro_1337
symbol: dusC
gene_biotype: protein_coding
description:
  Dihydrouridine synthase DuS; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U16 in tRNAs. Belongs to the Dus family. DusC subfamily.


ensembl_gene_id: Spro_1338
symbol: Spro_1338
gene_biotype: protein_coding
description:
  PFAM: N-acetyltransferase; KEGG: mxa:MXAN_1194 N-acetyltransferase family protein; Belongs to the arylamine N-acetyltransferase family.


ensembl_gene_id: Spro_1339
symbol: Spro_1339
gene_biotype: protein_coding
description:
  Transcriptional regulator, LysR family; PFAM: regulatory protein LysR; LysR substrate-binding; KEGG: bur:Bcep18194_B0248 transcriptional regulator, LysR family.


ensembl_gene_id: Spro_1341
symbol: Spro_1341
gene_biotype: protein_coding
description:
  Transcriptional regulator, LysR family; PFAM: regulatory protein LysR; LysR substrate-binding; KEGG: kpn:KPN_02452 putative bacterial regulatory protein, LysR; Belongs to the LysR transcriptional regulatory family.


ensembl_gene_id: Spro_1343
symbol: Spro_1343
gene_biotype: protein_coding
description:
  PFAM: polysaccharide biosynthesis protein; KEGG: afw:Anae109_1236 polysaccharide biosynthesis protein.


ensembl_gene_id: Spro_1345
symbol: Spro_1345
gene_biotype: protein_coding
description:
  Transcriptional regulator, LysR family; PFAM: regulatory protein LysR; LysR substrate-binding; KEGG: pin:Ping_2316 transcriptional regulator, substrate-binding of LysR family protein.


ensembl_gene_id: Spro_1349
symbol: Spro_1349
gene_biotype: protein_coding
description:
  Transcriptional regulator, LysR family; PFAM: regulatory protein LysR; LysR substrate-binding; KEGG: pap:PSPA7_2479 probable transcriptional regulator.


ensembl_gene_id: Spro_1351
symbol: Spro_1351
gene_biotype: protein_coding
description:
  Adenosylhomocysteinase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; S-adenosyl-L-homocysteine hydrolase, NAD binding; KEGG: kpn:KPN_02462 putative S-adenosylhomocysteine hydrolase.


ensembl_gene_id: Spro_1352
symbol: Spro_1352
gene_biotype: protein_coding
description:
  PFAM: peptidase S11 D-alanyl-D-alanine carboxypeptidase 1; KEGG: yen:YE2884 penicillin-binding protein 7 precursor; Belongs to the peptidase S11 family.


ensembl_gene_id: Spro_1353
symbol: Spro_1353
gene_biotype: protein_coding
description:
  PFAM: 3-demethylubiquinone-9 3-methyltransferase; KEGG: oan:Oant_1566 3-demethylubiquinone-9 3-methyltransferase.


ensembl_gene_id: Spro_1357
symbol: Spro_1357
gene_biotype: protein_coding
description:
  Transcriptional regulator, MerR family; PFAM: regulatory protein MerR; Albicidin resistance; Transcription regulator MerR DNA binding; KEGG: kpn:KPN_02240 putative albicidin resistance protein.


ensembl_gene_id: Spro_1359
symbol: Spro_1359
gene_biotype: protein_coding
description:
  TIGRFAM: lipoprotein, YaeC family; PFAM: NLPA lipoprotein; KEGG: eca:ECA1498 lipoprotein-28 precursor; Belongs to the nlpA lipoprotein family.


ensembl_gene_id: Spro_1362
symbol: Spro_1362
gene_biotype: protein_coding
description:
  PFAM: transferase hexapeptide repeat containing protein; KEGG: kpn:KPN_04414 UDP-3-O-(3-hydroxymyristoyl)-glucosamine N-acyltransferase.


ensembl_gene_id: Spro_1364
symbol: dld
gene_biotype: protein_coding
description:
  D-lactate dehydrogenase; Catalyzes the oxidation of D-lactate to pyruvate. Belongs to the quinone-dependent D-lactate dehydrogenase family.


ensembl_gene_id: Spro_1365
symbol: map
gene_biotype: protein_coding
description:
  Methionine aminopeptidase, type I; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.


ensembl_gene_id: Spro_1368
symbol: Spro_1368
gene_biotype: protein_coding
description:
  PFAM: extracellular solute-binding protein family 3; KEGG: bam:Bamb_0110 extracellular solute-binding protein, family 3; Belongs to the bacterial solute-binding protein 3 family.


ensembl_gene_id: Spro_1370
symbol: Spro_1370
gene_biotype: protein_coding
description:
  Transcriptional regulator, LysR family; PFAM: regulatory protein LysR; LysR substrate-binding; KEGG: pfl:PFL_4813 transcriptional regulator, LysR family.


ensembl_gene_id: Spro_1371
symbol: Spro_1371
gene_biotype: protein_coding
description:
  PFAM: glycoside hydrolase family 3 domain protein; KEGG: eca:ECA2790 periplasmic beta-glucosidase; Belongs to the glycosyl hydrolase 3 family.


ensembl_gene_id: Spro_1373
symbol: Spro_1373
gene_biotype: protein_coding
description:
  PFAM: transport system permease protein; KEGG: eca:ECA3095 ABC transporter permease protein; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.


ensembl_gene_id: Spro_1374
symbol: Spro_1374
gene_biotype: protein_coding
description:
  ABC transporter-related protein; PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: hin:HI1470 putative iron transport system ATP-binding protein.


ensembl_gene_id: Spro_1380
symbol: Spro_1380
gene_biotype: protein_coding
description:
  Transcriptional regulator, LysR family; PFAM: regulatory protein LysR; LysR substrate-binding; KEGG: pfo:Pfl_2438 transcriptional regulator, LysR family.


ensembl_gene_id: Spro_1382
symbol: lsrK
gene_biotype: protein_coding
description:
  Carbohydrate kinase FGGY; Catalyzes the phosphorylation of autoinducer-2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of (S)-4,5-dihydroxypentane-2,3-dione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position.


ensembl_gene_id: Spro_1383
symbol: lsrG
gene_biotype: protein_coding
description:
  Antibiotic biosynthesis monooxygenase; Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the conversion of (4S)-4-hydroxy-5- phosphonooxypentane-2,3-dione (P-DPD) to 3-hydroxy-5- phosphonooxypentane-2,4-dione (P-HPD); Belongs to the LsrG family.


ensembl_gene_id: Spro_1385
symbol: Spro_1385
gene_biotype: protein_coding
description:
  Transcriptional regulator, AraC family; PFAM: helix-turn-helix- domain containing protein AraC type; AraC protein arabinose-binding/dimerisation; KEGG: psa:PST_2925 transcriptional regulator, AraC family.


ensembl_gene_id: Spro_1387
symbol: Spro_1387
gene_biotype: protein_coding
description:
  PFAM: alpha amylase catalytic region; SMART: alpha amylase catalytic sub domain; KEGG: yen:YE1962 alpha-amylase.


ensembl_gene_id: Spro_1391
symbol: Spro_1391
gene_biotype: protein_coding
description:
  PFAM: GCN5-related N-acetyltransferase; regulatory protein MarR; KEGG: shn:Shewana3_3368 transcriptional regulator, MarR family with acetyltransferase activity.


ensembl_gene_id: Spro_1395
symbol: Spro_1395
gene_biotype: protein_coding
description:
  PFAM: NLPA lipoprotein; KEGG: ent:Ent638_1773 NlpA lipoprotein; Belongs to the nlpA lipoprotein family.


ensembl_gene_id: Spro_1396
symbol: Spro_1396
gene_biotype: protein_coding
description:
  PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: ent:Ent638_1772 binding-protein-dependent transport systems inner membrane component.


ensembl_gene_id: Spro_1397
symbol: metN
gene_biotype: protein_coding
description:
  ABC transporter-related protein; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system.


ensembl_gene_id: Spro_1399
symbol: Spro_1399
gene_biotype: protein_coding
description:
  Transcriptional regulator, LysR family; PFAM: regulatory protein LysR; LysR substrate-binding; KEGG: bte:BTH_I0388 transcriptional regulator, LysR family.


ensembl_gene_id: Spro_1400
symbol: Spro_1400
gene_biotype: protein_coding
description:
  PFAM: Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KEGG: bca:BCE_3496 quinone oxidoreductase.


ensembl_gene_id: Spro_1404
symbol: Spro_1404
gene_biotype: protein_coding
description:
  PFAM: NAD-dependent epimerase/dehydratase; short-chain dehydrogenase/reductase SDR; KR domain protein; KEGG: pae:PA1827 probable short-chain dehydrogenase.


ensembl_gene_id: Spro_1405
symbol: Spro_1405
gene_biotype: protein_coding
description:
  Transcriptional regulator, LysR family; PFAM: regulatory protein LysR; LysR substrate-binding; KEGG: bur:Bcep18194_B1001 transcriptional regulator, LysR family.


ensembl_gene_id: Spro_1406
symbol: Spro_1406
gene_biotype: protein_coding
description:
  KEGG: aha:AHA_0049 tryptophanyl-tRNA synthetase; TIGRFAM: tryptophanyl-tRNA synthetase; PFAM: aminoacyl-tRNA synthetase class Ib.


ensembl_gene_id: Spro_1408
symbol: Spro_1408
gene_biotype: protein_coding
description:
  Transcriptional regulator, GntR family; PFAM: GntR domain protein; KEGG: ecj:JW5792 predicted DNA-binding transcriptional regulator.


ensembl_gene_id: Spro_1409
symbol: Spro_1409
gene_biotype: protein_coding
description:
  PFAM: Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KEGG: ecs:ECs5318 putative oxidoreductase.


ensembl_gene_id: Spro_1410
symbol: phnC
gene_biotype: protein_coding
description:
  Phosphonate ABC transporter, ATPase subunit; Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphonates importer (TC 3.A.1.9.1) family.


ensembl_gene_id: Spro_1411
symbol: Spro_1411
gene_biotype: protein_coding
description:
  TIGRFAM: phosphonate ABC transporter, periplasmic phosphonate-binding protein; KEGG: yen:YE2877 putative substrate-binding periplasmic transport protein.


ensembl_gene_id: Spro_1412
symbol: Spro_1412
gene_biotype: protein_coding
description:
  TIGRFAM: phosphonate ABC transporter, inner membrane subunit; PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: ypi:YpsIP31758_2797 phosphonate ABC transporter, permease protein.


ensembl_gene_id: Spro_1413
symbol: Spro_1413
gene_biotype: protein_coding
description:
  TIGRFAM: phosphonate ABC transporter, inner membrane subunit; PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: ypi:YpsIP31758_2796 phosphonate ABC transporter, permease protein.


ensembl_gene_id: Spro_1415
symbol: Spro_1415
gene_biotype: protein_coding
description:
  PFAM: histidine kinase HAMP region domain protein; chemotaxis sensory transducer; KEGG: yen:YE2573 methyl-accepting chemotaxis protein.


ensembl_gene_id: Spro_1416
symbol: Spro_1416
gene_biotype: protein_coding
description:
  Sulphate transporter; PFAM: Xanthine/uracil/vitamin C permease; sulphate transporter; KEGG: kpn:KPN_04684 putative sulfate transporter.


ensembl_gene_id: Spro_1419
symbol: Spro_1419
gene_biotype: protein_coding
description:
  TIGRFAM: urea amidolyase related protein; Urea carboxylase; PFAM: biotin/lipoyl attachment domain-containing protein; Allophanate hydrolase subunit 2; Allophanate hydrolase subunit 1; Carbamoyl-phosphate synthase L chain ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; biotin carboxylase domain protein; RimK domain protein ATP-grasp; KEGG: pmy:Pmen_0703 UreA amidolyase related protein.


ensembl_gene_id: Spro_1420
symbol: Spro_1420
gene_biotype: protein_coding
description:
  Transcriptional regulator, GntR family; PFAM: regulatory protein GntR HTH; GntR domain protein; KEGG: eca:ECA2143 GntR-family transcriptional regulator.


ensembl_gene_id: Spro_1422
symbol: Spro_1422
gene_biotype: protein_coding
description:
  PFAM: inner-membrane translocator; KEGG: yen:YE2872 putative branched-chain amino acid transport system, permease component.


ensembl_gene_id: Spro_1423
symbol: Spro_1423
gene_biotype: protein_coding
description:
  PFAM: inner-membrane translocator; KEGG: yps:YPTB1230 ABC type branched-chain amino acid transporter, permease protein; Belongs to the binding-protein-dependent transport system permease family.


ensembl_gene_id: Spro_1424
symbol: Spro_1424
gene_biotype: protein_coding
description:
  ABC transporter-related protein; PFAM: ABC transporter related; KEGG: eca:ECA2147 putative ABC transport ATP-binding subunit.


ensembl_gene_id: Spro_1425
symbol: Spro_1425
gene_biotype: protein_coding
description:
  ABC transporter-related protein; PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: eca:ECA2148 putative ABC transport ATP-binding subunit.


ensembl_gene_id: Spro_1428
symbol: Spro_1428
gene_biotype: protein_coding
description:
  PFAM: GCN5-related N-acetyltransferase; KEGG: pfl:PFL_2567 acetyltransferase, GNAT family, putative.


ensembl_gene_id: Spro_1429
symbol: Spro_1429
gene_biotype: protein_coding
description:
  PFAM: monooxygenase FAD-binding; FAD dependent oxidoreductase; KEGG: nwi:Nwi_2327 hypothetical protein.


ensembl_gene_id: Spro_1431
symbol: Spro_1431
gene_biotype: protein_coding
description:
  Transcriptional regulator, LysR family; PFAM: regulatory protein LysR; LysR substrate-binding; KEGG: rle:RL4055 putative LysR family transcriptional regulator.


ensembl_gene_id: Spro_1439
symbol: Spro_1439
gene_biotype: protein_coding
description:
  Transcriptional regulator, AraC family; PFAM: helix-turn-helix- domain containing protein AraC type; KEGG: bld:BLi02818 hypothetical protein.


ensembl_gene_id: Spro_1440
symbol: Spro_1440
gene_biotype: protein_coding
description:
  Transcriptional regulator, GntR family with aminotransferase domain; PFAM: regulatory protein GntR HTH; aminotransferase class I and II; KEGG: pfo:Pfl_5531 aminotransferase, class I and II.


ensembl_gene_id: Spro_1443
symbol: Spro_1443
gene_biotype: protein_coding
description:
  PFAM: General substrate transporter; major facilitator superfamily MFS_1; KEGG: bxe:Bxe_C0113 major facilitator superfamily (MFS) transporter.


ensembl_gene_id: Spro_1445
symbol: Spro_1445
gene_biotype: protein_coding
description:
  PFAM: Substrate-binding region of ABC-type glycine betaine transport system; KEGG: yen:YE2865 putative substrate-binding transport protein.


ensembl_gene_id: Spro_1446
symbol: Spro_1446
gene_biotype: protein_coding
description:
  PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: ypi:YpsIP31758_2785 quaternary amine uptake ABC transporter (QAT) family, permease protein.


ensembl_gene_id: Spro_1447
symbol: Spro_1447
gene_biotype: protein_coding
description:
  ABC transporter-related protein; PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: yps:YPTB1238 ABC type choline/glycine/betaine transporter, ATP-binding subunit.


ensembl_gene_id: Spro_1448
symbol: Spro_1448
gene_biotype: protein_coding
description:
  PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: ypi:YpsIP31758_2783 quaternary amine uptake ABC transporter (QAT) family, permease protein.


ensembl_gene_id: Spro_1451
symbol: Spro_1451
gene_biotype: protein_coding
description:
  PFAM: protein of unknown function DUF6 transmembrane; KEGG: ypi:YpsIP31758_2779 integral membrane protein.


ensembl_gene_id: Spro_1454
symbol: Spro_1454
gene_biotype: protein_coding
description:
  Transcriptional regulator, XRE family; PFAM: helix-turn-helix domain protein; Cupin 2 conserved barrel domain protein; KEGG: sco:SCO6802 DNA-binding protein.


ensembl_gene_id: Spro_1456
symbol: Spro_1456
gene_biotype: protein_coding
description:
  TIGRFAM: 5'-nucleotidase, lipoprotein e(P4) family; PFAM: acid phosphatase (Class B); KEGG: oan:Oant_2497 5'-nucleotidase, lipoprotein E(P4) family.


ensembl_gene_id: Spro_1458
symbol: Spro_1458
gene_biotype: protein_coding
description:
  PFAM: porin Gram-negative type; KEGG: yen:YE2856 outer membrane protein C2; Belongs to the Gram-negative porin family.


ensembl_gene_id: Spro_1462
symbol: Spro_1462
gene_biotype: protein_coding
description:
  PFAM: regulatory protein AsnC/Lrp family; KEGG: kpn:KPN_02209 putative regulator for leucine (or lrp) regulon and high-affinity branched-chain amino acid transport system.


ensembl_gene_id: Spro_1463
symbol: Spro_1463
gene_biotype: protein_coding
description:
  PFAM: protein of unknown function DUF6 transmembrane; KEGG: ret:RHE_CH00327 putative transporter permease protein.


ensembl_gene_id: Spro_1464
symbol: Spro_1464
gene_biotype: protein_coding
description:
  SMART: helix-turn-helix domain protein; KEGG: rpa:RPA1926 possible transcriptional regulator, XRE family.


ensembl_gene_id: Spro_1470
symbol: rlmF
gene_biotype: protein_coding
description:
  Protein of unknown function DUF890; Specifically methylates the adenine in position 1618 of 23S rRNA.


ensembl_gene_id: Spro_1472
symbol: Spro_1472
gene_biotype: protein_coding
description:
  KEGG: ypp:YPDSF_1927 chemotactic transducer; TIGRFAM: PAS sensor protein; PFAM: chemotaxis sensory transducer; PAS fold-3 domain protein; PAS fold-4 domain protein; PAS fold domain protein; SMART: PAS domain containing protein; PAC repeat-containing protein.


ensembl_gene_id: Spro_1477
symbol: Spro_1477
gene_biotype: protein_coding
description:
  ABC transporter-related protein; PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: sbo:SBO_0700 ATP-binding component of glutamine high-affinity transport system.


ensembl_gene_id: Spro_1478
symbol: Spro_1478
gene_biotype: protein_coding
description:
  TIGRFAM: polar amino acid ABC transporter, inner membrane subunit; PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: kpn:KPN_00839 glutamine ABC transporter permease component.


ensembl_gene_id: Spro_1479
symbol: Spro_1479
gene_biotype: protein_coding
description:
  KEGG: kpn:KPN_00840 glutamine ABC transporter periplasmic-binding protein; TIGRFAM: cationic amino acid ABC transporter, periplasmic binding protein; PFAM: extracellular solute-binding protein family 3; SMART: ionotropic glutamate receptor.


ensembl_gene_id: Spro_1480
symbol: Spro_1480
gene_biotype: protein_coding
description:
  Transcriptional regulator, TraR/DksA family; PFAM: zinc finger DksA/TraR C4-type; KEGG: yen:YE2844 DksA/TraR C4-type zinc finger protein.


ensembl_gene_id: Spro_1481
symbol: dps
gene_biotype: protein_coding
description:
  Ferritin Dps family protein; During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co-crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction.


ensembl_gene_id: Spro_1483
symbol: Spro_1483
gene_biotype: protein_coding
description:
  PFAM: protein of unknown function DUF6 transmembrane; KEGG: ypi:YpsIP31758_1500 integral membrane protein.


ensembl_gene_id: Spro_1484
symbol: Spro_1484
gene_biotype: protein_coding
description:
  PFAM: OmpA domain protein transmembrane region-containing protein; virulence-related outer membrane protein; KEGG: eca:ECA2764 outer membrane protein X.


ensembl_gene_id: Spro_1485
symbol: Spro_1485
gene_biotype: protein_coding
description:
  PFAM: Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase; KEGG: ent:Ent638_1888 nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase.


ensembl_gene_id: Spro_1486
symbol: Spro_1486
gene_biotype: protein_coding
description:
  Transcriptional regulator, LysR family; PFAM: regulatory protein LysR; LysR substrate-binding; KEGG: yen:YE2048 LysR-family transcriptional regulatory protein.


ensembl_gene_id: Spro_1487
symbol: Spro_1487
gene_biotype: protein_coding
description:
  PFAM: GCN5-related N-acetyltransferase; KEGG: bxe:Bxe_B0244 putative acetyltransferase, GnaT family.


ensembl_gene_id: Spro_1488
symbol: Spro_1488
gene_biotype: protein_coding
description:
  TIGRFAM: gluconate transporter; PFAM: Gluconate transporter; Citrate transporter; KEGG: ecc:c3301 hypothetical permease ygbN.


ensembl_gene_id: Spro_1489
symbol: Spro_1489
gene_biotype: protein_coding
description:
  PFAM: Xylose isomerase domain protein TIM barrel; KEGG: eca:ECA4330 putative isomerase; Belongs to the hyi family.


ensembl_gene_id: Spro_1490
symbol: Spro_1490
gene_biotype: protein_coding
description:
  PFAM: class II aldolase/adducin family protein; KEGG: yen:YE2502 putative class II aldolase-family protein.


ensembl_gene_id: Spro_1492
symbol: Spro_1492
gene_biotype: protein_coding
description:
  2-hydroxy-3-oxopropionate reductase; PFAM: 6-phosphogluconate dehydrogenase NAD-binding; 3-hydroxyacyl-CoA dehydrogenase NAD-binding; KEGG: eca:ECA4327 putative oxidoreductase.


ensembl_gene_id: Spro_1493
symbol: Spro_1493
gene_biotype: protein_coding
description:
  Transcriptional regulator, DeoR family; PFAM: regulatory protein DeoR; Helix-turn-helix type 11 domain protein; KEGG: eca:ECA4325 DeoR-family trancriptional regulator.


ensembl_gene_id: Spro_1495
symbol: Spro_1495
gene_biotype: protein_coding
description:
  PFAM: oxidoreductase molybdopterin binding; KEGG: psb:Psyr_3371 oxidoreductase, molybdopterin binding.


ensembl_gene_id: Spro_1498
symbol: Spro_1498
gene_biotype: protein_coding
description:
  TIGRFAM: heavy metal response regulator; PFAM: response regulator receiver; transcriptional regulator domain protein; KEGG: pae:PA4885 two-component response regulator.


ensembl_gene_id: Spro_1499
symbol: Spro_1499
gene_biotype: protein_coding
description:
  Heavy metal sensor signal transduction histidine kinase; Member of a two-component regulatory system.


ensembl_gene_id: Spro_1500
symbol: Spro_1500
gene_biotype: protein_coding
description:
  Transcriptional regulator, CadC; PFAM: transcriptional regulator domain protein; KEGG: ecp:ECP_4609 hypothetical protein.


ensembl_gene_id: Spro_1507
symbol: Spro_1507
gene_biotype: protein_coding
description:
  Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; KEGG: pol:Bpro_0544 periplasmic sensor signal transduction histidine kinase.


ensembl_gene_id: Spro_1508
symbol: Spro_1508
gene_biotype: protein_coding
description:
  Two component transcriptional regulator, winged helix family; PFAM: response regulator receiver; transcriptional regulator domain protein; KEGG: bur:Bcep18194_C6809 two component transcriptional regulator, winged helix family.


ensembl_gene_id: Spro_1510
symbol: Spro_1510
gene_biotype: protein_coding
description:
  PFAM: oxidoreductase molybdopterin binding; KEGG: pol:Bpro_2730 oxidoreductase, molybdopterin binding.


ensembl_gene_id: Spro_1512
symbol: Spro_1512
gene_biotype: protein_coding
description:
  TIGRFAM: choline/carnitine/betaine transporter; PFAM: BCCT transporter; KEGG: eca:ECA1743 high-affinity choline transport protein; Belongs to the BCCT transporter (TC 2.A.15) family.


ensembl_gene_id: Spro_1513
symbol: betI
gene_biotype: protein_coding
description:
  Transcriptional regulator, TetR family; Repressor involved in the biosynthesis of the osmoprotectant glycine betaine. It represses transcription of the choline transporter BetT and the genes of BetAB involved in the synthesis of glycine betaine (By similarity).


ensembl_gene_id: Spro_1514
symbol: betB
gene_biotype: protein_coding
description:
  Betaine aldehyde dehydrogenase; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid.


ensembl_gene_id: Spro_1515
symbol: betA
gene_biotype: protein_coding
description:
  Choline dehydrogenase; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.


ensembl_gene_id: Spro_1521
symbol: Spro_1521
gene_biotype: protein_coding
description:
  PFAM: fimbrial biogenesis outer membrane usher protein; KEGG: kpn:KPN_02986 outer membrane protein; export and assembly of type 1 fimbriae.


ensembl_gene_id: Spro_1523
symbol: Spro_1523
gene_biotype: protein_coding
description:
  Transcriptional regulator, AraC family; PFAM: helix-turn-helix- domain containing protein AraC type; KEGG: sgl:SG0402 right origin-binding protein.


ensembl_gene_id: Spro_1524
symbol: mqo
gene_biotype: protein_coding
description:
  KEGG: eca:ECA3082 malate:quinone oxidoreductase; TIGRFAM: malate--quinone oxidoreductase; PFAM: FAD dependent oxidoreductase; Malate:quinone-oxidoreductase.


ensembl_gene_id: Spro_1528
symbol: Spro_1528
gene_biotype: protein_coding
description:
  PFAM: Alkaline phosphatase; KEGG: yen:YE2068 alkaline phosphatase precursor; Belongs to the alkaline phosphatase family.


ensembl_gene_id: Spro_1529
symbol: Spro_1529
gene_biotype: protein_coding
description:
  PFAM: Glutathione S-transferase domain; KEGG: mlo:mlr4954 glutathione S-transferase; Belongs to the GST superfamily.


ensembl_gene_id: Spro_1533
symbol: cynS
gene_biotype: protein_coding
description:
  Cyanate lyase; Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide; Belongs to the cyanase family.


ensembl_gene_id: Spro_1535
symbol: Spro_1535
gene_biotype: protein_coding
description:
  Transcriptional regulator, LysR family; PFAM: regulatory protein LysR; LysR substrate-binding; KEGG: pfl:PFL_1492 transcriptional regulator CynR.


ensembl_gene_id: Spro_1541
symbol: Spro_1541
gene_biotype: protein_coding
description:
  Transcriptional regulator, XRE family; PFAM: helix-turn-helix domain protein; KEGG: plu:plu4475 hypothetical protein.


ensembl_gene_id: Spro_1545
symbol: Spro_1545
gene_biotype: protein_coding
description:
  ABC transporter-related protein; PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: eca:ECA3010 ABC transporter ATP-binding protein.


ensembl_gene_id: Spro_1546
symbol: Spro_1546
gene_biotype: protein_coding
description:
  TIGRFAM: molybdopterin synthase sulfurylase MoeB; PFAM: UBA/THIF-type NAD/FAD binding protein; MoeZ/MoeB domain protein; KEGG: yen:YE2829 molybdopterin biosynthesis protein.


ensembl_gene_id: Spro_1547
symbol: Spro_1547
gene_biotype: protein_coding
description:
  Molybdenum cofactor synthesis domain; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family.


ensembl_gene_id: Spro_1550
symbol: Spro_1550
gene_biotype: protein_coding
description:
  ABC transporter-related protein; PFAM: ABC transporter related; Oligopeptide/dipeptide ABC transporter domain protein; SMART: AAA ATPase; KEGG: eca:ECA2835 putative ABC transporter ATP-binding protein; Belongs to the ABC transporter superfamily.


ensembl_gene_id: Spro_1551
symbol: Spro_1551
gene_biotype: protein_coding
description:
  PFAM: extracellular solute-binding protein family 5; KEGG: eca:ECA2834 putative ABC transporter periplasmic binding protein.


ensembl_gene_id: Spro_1552
symbol: Spro_1552
gene_biotype: protein_coding
description:
  PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: eca:ECA2833 putative ABC transporter permease protein.


ensembl_gene_id: Spro_1553
symbol: Spro_1553
gene_biotype: protein_coding
description:
  PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: ent:Ent638_1326 binding-protein-dependent transport systems inner membrane component.


ensembl_gene_id: Spro_1557
symbol: Spro_1557
gene_biotype: protein_coding
description:
  TIGRFAM: Alcohol dehydrogenase class III/S-(hydroxymethyl)glutathione dehydrogenase; PFAM: Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KEGG: yen:YE2821 probable alcohol dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.


ensembl_gene_id: Spro_1558
symbol: Spro_1558
gene_biotype: protein_coding
description:
  Transcriptional regulator, LysR family; PFAM: regulatory protein LysR; LysR substrate-binding; KEGG: yen:YE2820 putative LysR-family transcriptional regulatory protein.


ensembl_gene_id: Spro_1559
symbol: Spro_1559
gene_biotype: protein_coding
description:
  PFAM: protein of unknown function DUF1228; major facilitator superfamily MFS_1; KEGG: yen:YE2819 hypothetical protein.


ensembl_gene_id: Spro_1561
symbol: Spro_1561
gene_biotype: protein_coding
description:
  PFAM: protein of unknown function DUF405; protein of unknown function DUF418; KEGG: yen:YE2817 hypothetical protein.


ensembl_gene_id: Spro_1562
symbol: Spro_1562
gene_biotype: protein_coding
description:
  Transcriptional regulator, LacI family; PFAM: regulatory protein LacI; periplasmic binding protein/LacI transcriptional regulator; KEGG: yen:YE2816 mgl repressor and galactose ultrainduction factor.


ensembl_gene_id: Spro_1563
symbol: Spro_1563
gene_biotype: protein_coding
description:
  PFAM: periplasmic binding protein/LacI transcriptional regulator; KEGG: yen:YE2815 galactose-binding protein.


ensembl_gene_id: Spro_1564
symbol: Spro_1564
gene_biotype: protein_coding
description:
  ABC transporter-related protein; PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: yen:YE2814 galactoside transport ATP-binding protein.


ensembl_gene_id: Spro_1565
symbol: Spro_1565
gene_biotype: protein_coding
description:
  Monosaccharide-transporting ATPase; PFAM: inner-membrane translocator; KEGG: ypi:YpsIP31758_2465 galactose ABC transporter, permease protein; Belongs to the binding-protein-dependent transport system permease family.


ensembl_gene_id: Spro_1567
symbol: maeA
gene_biotype: protein_coding
description:
  Malate dehydrogenase (oxaloacetate-decarboxylating); PFAM: malic protein domain protein; malic protein NAD-binding; KEGG: yen:YE2794 NAD-dependent malic enzyme; Belongs to the malic enzymes family.


ensembl_gene_id: Spro_1568
symbol: cdd
gene_biotype: protein_coding
description:
  Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.


ensembl_gene_id: Spro_1573
symbol: metG
gene_biotype: protein_coding
description:
  methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.


ensembl_gene_id: Spro_1574
symbol: Spro_1574
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family.


ensembl_gene_id: Spro_1579
symbol: Spro_1579
gene_biotype: protein_coding
description:
  TIGRFAM: anaerobic c4-dicarboxylate antiporter, DcuC family; PFAM: C4-dicarboxylate anaerobic carrier; TRAP C4-dicarboxylate transport system permease DctM subunit; KEGG: yen:YE2780 anaerobic C4-dicarboxylate transporter.


ensembl_gene_id: Spro_1580
symbol: Spro_1580
gene_biotype: protein_coding
description:
  Integral membrane protein TerC; PFAM: CBS domain containing protein; transporter-associated region; Integral membrane protein TerC; KEGG: yen:YE2779 hypothetical protein.


ensembl_gene_id: Spro_1581
symbol: Spro_1581
gene_biotype: protein_coding
description:
  TIGRFAM: UTP-glucose-1-phosphate uridylyltransferase; PFAM: Nucleotidyl transferase; KEGG: yen:YE2778 UTP-glucose-1-phosphate uridylyltransferase.


ensembl_gene_id: Spro_1582
symbol: Spro_1582
gene_biotype: protein_coding
description:
  TIGRFAM: UTP-glucose-1-phosphate uridylyltransferase; PFAM: Nucleotidyl transferase; KEGG: yen:YE2777 UTP-glucose-1-phosphate uridylyltransferase.


ensembl_gene_id: Spro_1584
symbol: Spro_1584
gene_biotype: protein_coding
description:
  PFAM: low molecular weight phosphotyrosine protein phosphatase; KEGG: kpn:KPN_02511 protein tyrosine phosphatase.


ensembl_gene_id: Spro_1585
symbol: Spro_1585
gene_biotype: protein_coding
description:
  Non-specific protein-tyrosine kinase; PFAM: lipopolysaccharide biosynthesis protein; KEGG: kpn:KPN_02510 tyrosine autokinase.


ensembl_gene_id: Spro_1593
symbol: Spro_1593
gene_biotype: protein_coding
description:
  KEGG: pst:PSPTO_5546 hypothetical protein; Belongs to the glycosyl hydrolase 5 (cellulase A) family.


ensembl_gene_id: Spro_1596
symbol: Spro_1596
gene_biotype: protein_coding
description:
  Type I secretion system ATPase; KEGG: plu:plu0657 ATP-binding protein PrtB; TIGRFAM: type I secretion system ATPase; PFAM: ABC transporter transmembrane region; ABC transporter related; SMART: AAA ATPase.


ensembl_gene_id: Spro_1597
symbol: Spro_1597
gene_biotype: protein_coding
description:
  TIGRFAM: type I secretion membrane fusion protein, HlyD family; PFAM: secretion protein HlyD family protein; KEGG: plu:plu0658 membrane fusion protein PrtC.


ensembl_gene_id: Spro_1598
symbol: Spro_1598
gene_biotype: protein_coding
description:
  TIGRFAM: type I secretion outer membrane protein, TolC family; PFAM: outer membrane efflux protein; KEGG: plu:plu0659 outer membrane protein PrtD.


ensembl_gene_id: Spro_1599
symbol: Spro_1599
gene_biotype: protein_coding
description:
  KEGG: eca:ECA1438 mannose-1-phosphate guanylyltransferase; TIGRFAM: mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; PFAM: mannose-6-phosphate isomerase type II; Nucleotidyl transferase; Cupin 2 conserved barrel domain protein.


ensembl_gene_id: Spro_1600
symbol: Spro_1600
gene_biotype: protein_coding
description:
  Phosphomannomutase; PFAM: phosphoglucomutase/phosphomannomutase; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III; KEGG: ent:Ent638_2662 phosphomannomutase.


ensembl_gene_id: Spro_1608
symbol: Spro_1608
gene_biotype: protein_coding
description:
  6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.


ensembl_gene_id: Spro_1609
symbol: hisI
gene_biotype: protein_coding
description:
  PFAM: phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; KEGG: yen:YE2772 histidine biosynthesis bifunctional protein [includes: phosphoribosyl-amp cyclohydrolase; In the N-terminal section; belongs to the PRA-CH family.


ensembl_gene_id: Spro_1610
symbol: hisF
gene_biotype: protein_coding
description:
  Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.


ensembl_gene_id: Spro_1611
symbol: hisA
gene_biotype: protein_coding
description:
  TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; PFAM: deoxyribose-phosphate aldolase/phospho-2-dehydro-3-deoxyheptonate aldolase; histidine biosynthesis protein; KEGG: ypi:YpsIP31758_2433 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.


ensembl_gene_id: Spro_1612
symbol: hisH
gene_biotype: protein_coding
description:
  Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.


ensembl_gene_id: Spro_1613
symbol: hisB
gene_biotype: protein_coding
description:
  KEGG: yen:YE2768 histidinol-phosphatase and imidazoleglycerol-phosphate dehydratase; TIGRFAM: histidinol-phosphatase; histidinol-phosphate phosphatase family protein; hydrolase, HAD-superfamily, subfamily IIIA; PFAM: imidazoleglycerol-phosphate dehydratase; In the N-terminal section; belongs to the histidinol- phosphatase family.


ensembl_gene_id: Spro_1614
symbol: hisC
gene_biotype: protein_coding
description:
  TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; KEGG: yen:YE2767 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.


ensembl_gene_id: Spro_1615
symbol: hisD
gene_biotype: protein_coding
description:
  Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.


ensembl_gene_id: Spro_1616
symbol: hisG
gene_biotype: protein_coding
description:
  ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.


ensembl_gene_id: Spro_1618
symbol: Spro_1618
gene_biotype: protein_coding
description:
  Transcriptional regulator, LysR family; PFAM: regulatory protein LysR; LysR substrate-binding; KEGG: pae:PA1145 probable transcriptional regulator.


ensembl_gene_id: Spro_1619
symbol: Spro_1619
gene_biotype: protein_coding
description:
  TIGRFAM: putative agmatinase; PFAM: Arginase/agmatinase/formiminoglutamase; KEGG: bmn:BMA10247_A0674 agmatinase; Belongs to the arginase family.


ensembl_gene_id: Spro_1620
symbol: Spro_1620
gene_biotype: protein_coding
description:
  PFAM: Na+/solute symporter; KEGG: pae:PA1418 probable sodium:solute symport protein; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.


ensembl_gene_id: Spro_1621
symbol: Spro_1621
gene_biotype: protein_coding
description:
  PFAM: Mg2 transporter protein CorA family protein; KEGG: reh:H16_A0087 putative Mg2+ and Co2+ transporter.


ensembl_gene_id: Spro_1622
symbol: Spro_1622
gene_biotype: protein_coding
description:
  PFAM: GCN5-related N-acetyltransferase; KEGG: hch:HCH_01386 histone acetyltransferase HPA2/related acetyltransferase.


ensembl_gene_id: Spro_1624
symbol: Spro_1624
gene_biotype: protein_coding
description:
  TIGRFAM: HAD-superfamily hydrolase, subfamily IB (PSPase-like); HAD-superfamily subfamily IB hydrolase, TIGR01490; KEGG: yen:YE1464 putative hydrolase.


ensembl_gene_id: Spro_1625
symbol: Spro_1625
gene_biotype: protein_coding
description:
  PFAM: 2OG-Fe(II) oxygenase; KEGG: yen:YE1465 putative iron/ascorbate oxidoreductase family protein; Belongs to the iron/ascorbate-dependent oxidoreductase family.


ensembl_gene_id: Spro_1626
symbol: Spro_1626
gene_biotype: protein_coding
description:
  Cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: yen:YE1469 putative cystathionine gamma-synthase.


ensembl_gene_id: Spro_1627
symbol: Spro_1627
gene_biotype: protein_coding
description:
  PFAM: CBS domain containing protein; Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: yen:YE1470 cystathionine beta-lyase.


ensembl_gene_id: Spro_1628
symbol: Spro_1628
gene_biotype: protein_coding
description:
  Serine-type D-Ala-D-Ala carboxypeptidase; PFAM: peptidase S11 D-alanyl-D-alanine carboxypeptidase 1; Penicillin-binding protein 5 domain protein; KEGG: yen:YE1471 D-alanyl-D-alanine carboxypeptidase; Belongs to the peptidase S11 family.


ensembl_gene_id: Spro_1629
symbol: Spro_1629
gene_biotype: protein_coding
description:
  KEGG: yen:YE1472 L-serine dehydratase 2; TIGRFAM: L-serine dehydratase 1; PFAM: serine dehydratase alpha chain; serine dehydratase beta chain; Belongs to the iron-sulfur dependent L-serine dehydratase family.


ensembl_gene_id: Spro_1630
symbol: Spro_1630
gene_biotype: protein_coding
description:
  TIGRFAM: serine transporter; PFAM: aromatic amino acid permease; KEGG: yen:YE1473 serine transporter.


ensembl_gene_id: Spro_1631
symbol: Spro_1631
gene_biotype: protein_coding
description:
  Transcriptional regulator, DeoR family; PFAM: regulatory protein DeoR; KEGG: yen:YE1474 deoxyribose operon repressor.


ensembl_gene_id: Spro_1632
symbol: deoC-2
gene_biotype: protein_coding
description:
  Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.


ensembl_gene_id: Spro_1634
symbol: Spro_1634
gene_biotype: protein_coding
description:
  Undecaprenyl-diphosphatase; PFAM: phosphoesterase PA-phosphatase related; KEGG: yen:YE1476 putative permease.


ensembl_gene_id: Spro_1636
symbol: Spro_1636
gene_biotype: protein_coding
description:
  PFAM: purine or other phosphorylase family 1; KEGG: btl:BALH_2989 putative 5-methylthioadenosine nucleosidase/S-adenosylhomocysteine nucleosidase.


ensembl_gene_id: Spro_1637
symbol: eco
gene_biotype: protein_coding
description:
  Proteinase inhibitor I11 ecotin; General inhibitor of pancreatic serine proteases: inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases.


ensembl_gene_id: Spro_1638
symbol: Spro_1638
gene_biotype: protein_coding
description:
  PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: pfl:PFL_3440 serine/threonine dehydratase family protein.


ensembl_gene_id: Spro_1639
symbol: Spro_1639
gene_biotype: protein_coding
description:
  TIGRFAM: YidE/YbjL duplication; PFAM: TrkA-C domain protein; YidE/YbjL duplication domain protein; KEGG: yen:YE1478 TrkA, potassium channel-family protein.


ensembl_gene_id: Spro_1643
symbol: rimK
gene_biotype: protein_coding
description:
  TIGRFAM: alpha-L-glutamate ligase, RimK family; PFAM: protein of unknown function DUF201; RimK domain protein ATP-grasp; KEGG: stm:STM0875 ribosomal protein S6 modification protein.


ensembl_gene_id: Spro_1645
symbol: Spro_1645
gene_biotype: protein_coding
description:
  Extracellular solute-binding protein family 1; Required for the activity of the bacterial periplasmic transport system of putrescine; Belongs to the bacterial solute-binding protein PotD/PotF family.


ensembl_gene_id: Spro_1646
symbol: potA
gene_biotype: protein_coding
description:
  Spermidine/putrescine ABC transporter ATPase subunit; Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.


ensembl_gene_id: Spro_1647
symbol: Spro_1647
gene_biotype: protein_coding
description:
  PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: yen:YE1486 putrescine transport system permease protein.


ensembl_gene_id: Spro_1648
symbol: Spro_1648
gene_biotype: protein_coding
description:
  Ornithine carbamoyltransferase; PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: ypi:YpsIP31758_2642 putrescine ABC transporter, permease protein.


ensembl_gene_id: Spro_1650
symbol: rlmC
gene_biotype: protein_coding
description:
  23S rRNA (uracil-5-)-methyltransferase RumB; Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmC subfamily.


ensembl_gene_id: Spro_1652
symbol: Spro_1652
gene_biotype: protein_coding
description:
  KEGG: ypi:YpsIP31758_2639 arginine ABC transporter, periplasmic substrate-binding protein ArtJ; TIGRFAM: cationic amino acid ABC transporter, periplasmic binding protein; PFAM: extracellular solute-binding protein family 3; SMART: ionotropic glutamate receptor.


ensembl_gene_id: Spro_1653
symbol: Spro_1653
gene_biotype: protein_coding
description:
  TIGRFAM: polar amino acid ABC transporter, inner membrane subunit; PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: yen:YE1493 arginine transport system permease protein.


ensembl_gene_id: Spro_1654
symbol: Spro_1654
gene_biotype: protein_coding
description:
  TIGRFAM: polar amino acid ABC transporter, inner membrane subunit; PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: yen:YE1494 arginine transport system permease protein.


ensembl_gene_id: Spro_1655
symbol: Spro_1655
gene_biotype: protein_coding
description:
  KEGG: yen:YE1495 arginine-binding periplasmic protein 1 precursor; TIGRFAM: cationic amino acid ABC transporter, periplasmic binding protein; PFAM: extracellular solute-binding protein family 3; SMART: ionotropic glutamate receptor.


ensembl_gene_id: Spro_1656
symbol: Spro_1656
gene_biotype: protein_coding
description:
  ABC transporter-related protein; PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: yen:YE1496 arginine transport ATP-binding protein.


ensembl_gene_id: Spro_1658
symbol: Spro_1658
gene_biotype: protein_coding
description:
  PFAM: protein of unknown function DUF74; KEGG: eca:ECA2666 hypothetical protein; Belongs to the UPF0145 family.


ensembl_gene_id: Spro_1659
symbol: Spro_1659
gene_biotype: protein_coding
description:
  N-acetylmuramyl-L-alanine amidase, negative regulator of AmpC, AmpD; PFAM: N-acetylmuramoyl-L-alanine amidase family 2; KEGG: eca:ECA2665 putative N-acetylmuramoyl-L-alanine amidase.


ensembl_gene_id: Spro_1660
symbol: Spro_1660
gene_biotype: protein_coding
description:
  PFAM: NAD-dependent epimerase/dehydratase; 3-beta hydroxysteroid dehydrogenase/isomerase; dTDP-4-dehydrorhamnose reductase; Male sterility domain; KEGG: yen:YE1503 hypothetical protein.


ensembl_gene_id: Spro_1661
symbol: Spro_1661
gene_biotype: protein_coding
description:
  PFAM: NAD-dependent epimerase/dehydratase; 3-beta hydroxysteroid dehydrogenase/isomerase; KEGG: ypi:YpsIP31758_2621 NAD dependent epimerase/dehydratase family protein.


ensembl_gene_id: Spro_1663
symbol: Spro_1663
gene_biotype: protein_coding
description:
  Threonine aldolase; PFAM: aminotransferase class V; aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: yen:YE1505 L-allo-threonine aldolase.


ensembl_gene_id: Spro_1664
symbol: Spro_1664
gene_biotype: protein_coding
description:
  PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: yps:YPTB1384 pyruvate dehydrogenase; Belongs to the TPP enzyme family.


ensembl_gene_id: Spro_1665
symbol: Spro_1665
gene_biotype: protein_coding
description:
  PFAM: ferredoxin; oxidoreductase FAD/NAD(P)-binding domain protein; Oxidoreductase FAD-binding domain protein; KEGG: eca:ECA2663 NADH oxidoreductase.


ensembl_gene_id: Spro_1670
symbol: Spro_1670
gene_biotype: protein_coding
description:
  TIGRFAM: efflux transporter, RND family, MFP subunit; PFAM: secretion protein HlyD family protein; KEGG: yen:YE1514 putative HlyD family secretion protein; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.


ensembl_gene_id: Spro_1671
symbol: macB
gene_biotype: protein_coding
description:
  ABC transporter-related protein; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.


ensembl_gene_id: Spro_1672
symbol: Spro_1672
gene_biotype: protein_coding
description:
  Cold-shock DNA-binding domain protein; KEGG: stm:STM0943 similar to CspA but not cold shock induced; TIGRFAM: cold shock domain protein CspD; PFAM: Cold-shock protein DNA-binding; SMART: Cold shock protein.


ensembl_gene_id: Spro_1673
symbol: clpS
gene_biotype: protein_coding
description:
  ATP-dependent Clp protease adaptor protein ClpS; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family.


ensembl_gene_id: Spro_1674
symbol: Spro_1674
gene_biotype: protein_coding
description:
  KEGG: yen:YE1518 ATP-dependent Clp protease ATP-binding subunit; TIGRFAM: ATP-dependent Clp protease, ATP-binding subunit clpA; PFAM: AAA ATPase central domain protein; Clp domain protein; ATPase associated with various cellular activities AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family.


ensembl_gene_id: Spro_1675
symbol: infA
gene_biotype: protein_coding
description:
  Translation initiation factor IF-1; One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.


ensembl_gene_id: Spro_1676
symbol: aat
gene_biotype: protein_coding
description:
  Leucyltransferase; Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl- tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.


ensembl_gene_id: Spro_1677
symbol: Spro_1677
gene_biotype: protein_coding
description:
  KEGG: yen:YE1521 transport ATP-binding protein; TIGRFAM: ABC transporter CydDC cysteine exporter (CydDC-E) family permease/ATP-binding protein CydC; PFAM: ABC transporter related; SMART: AAA ATPase.


ensembl_gene_id: Spro_1678
symbol: Spro_1678
gene_biotype: protein_coding
description:
  KEGG: yps:YPTB1398 putative ABC cytochrome efflux transporter, fused ATP-binding and permease domains; TIGRFAM: ABC transporter CydDC cysteine exporter (CydDC-E) family permease/ATP-binding protein CydD; PFAM: ABC transporter transmembrane region; ABC transporter related; SMART: AAA ATPase.


ensembl_gene_id: Spro_1679
symbol: Spro_1679
gene_biotype: protein_coding
description:
  PFAM: Glutathione S-transferase domain; KEGG: pfo:Pfl_2442 glutathione S-transferase-like; Belongs to the GST superfamily.


ensembl_gene_id: Spro_1680
symbol: Spro_1680
gene_biotype: protein_coding
description:
  Transcriptional regulator, LysR family; PFAM: regulatory protein LysR; LysR substrate-binding; KEGG: pfl:PFL_4591 transcriptional regulator, LysR family.


ensembl_gene_id: Spro_1681
symbol: Spro_1681
gene_biotype: protein_coding
description:
  TIGRFAM: thioredoxin reductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: yen:YE1523 thioredoxin reductase.


ensembl_gene_id: Spro_1684
symbol: lolA
gene_biotype: protein_coding
description:
  Outer membrane lipoprotein carrier protein LolA; Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane).


ensembl_gene_id: Spro_1685
symbol: Spro_1685
gene_biotype: protein_coding
description:
  PFAM: magnesium chelatase ChlI subunit; AAA ATPase central domain protein; SMART: AAA ATPase; KEGG: yen:YE1527 putative ATPase protein.


ensembl_gene_id: Spro_1686
symbol: serS
gene_biotype: protein_coding
description:
  seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec).


ensembl_gene_id: Spro_1687
symbol: Spro_1687
gene_biotype: protein_coding
description:
  TIGRFAM: anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; PFAM: molybdopterin oxidoreductase; molydopterin dinucleotide-binding region; molybdopterin oxidoreductase Fe4S4 region; KEGG: kpn:KPN_01580 putative dimethyl sulfoxide reductase, major subunit; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.


ensembl_gene_id: Spro_1688
symbol: Spro_1688
gene_biotype: protein_coding
description:
  TIGRFAM: Dimethylsulfoxide reductase chain B; PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; KEGG: kpn:KPN_00927 anaerobic dimethyl sulfoxide (DMSO) reductase, subunit B.


ensembl_gene_id: Spro_1689
symbol: Spro_1689
gene_biotype: protein_coding
description:
  PFAM: DMSO reductase anchor subunit (DmsC); KEGG: ypp:YPDSF_3037 anaerobic dimethyl sulfoxide reductase chain C.


ensembl_gene_id: Spro_1690
symbol: dmsD
gene_biotype: protein_coding
description:
  Cytoplasmic chaperone TorD family protein; Required for biogenesis/assembly of DMSO reductase, but not for the interaction of the DmsA signal peptide with the Tat system. May be part of a chaperone cascade complex that facilitates a folding- maturation pathway for the substrate protein.


ensembl_gene_id: Spro_1697
symbol: Spro_1697
gene_biotype: protein_coding
description:
  TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; HAD-superfamily hydrolase, subfamily IA, variant 1; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: plu:plu2182 hypothetical protein.


ensembl_gene_id: Spro_1698
symbol: Spro_1698
gene_biotype: protein_coding
description:
  TIGRFAM: amino acid adenylation domain; PFAM: AMP-dependent synthetase and ligase; Thioesterase; phosphopantetheine-binding; KEGG: plu:plu2186 hypothetical protein.


ensembl_gene_id: Spro_1699
symbol: psuG
gene_biotype: protein_coding
description:
  Indigoidine synthase A family protein; Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway; Belongs to the pseudouridine-5'-phosphate glycosidase family.


ensembl_gene_id: Spro_1701
symbol: Spro_1701
gene_biotype: protein_coding
description:
  Pyruvate formate-lyase activating enzyme; Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family.


ensembl_gene_id: Spro_1702
symbol: Spro_1702
gene_biotype: protein_coding
description:
  KEGG: yen:YE1532 formate acetyltransferase 1; TIGRFAM: formate acetyltransferase; PFAM: formate C-acetyltransferase glycine radical; pyruvate formate-lyase PFL.


ensembl_gene_id: Spro_1705
symbol: Spro_1705
gene_biotype: protein_coding
description:
  TIGRFAM: L-asparaginase, type II; PFAM: Asparaginase/glutaminase; KEGG: sdy:SDY_3115 periplasmic L-asparaginase II; Belongs to the asparaginase 1 family.


ensembl_gene_id: Spro_1706
symbol: serC
gene_biotype: protein_coding
description:
  Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.


ensembl_gene_id: Spro_1707
symbol: aroA
gene_biotype: protein_coding
description:
  3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.


ensembl_gene_id: Spro_1708
symbol: cmk
gene_biotype: protein_coding
description:
  Cytidylate kinase; KEGG: ypi:YpsIP31758_2581 cytidylate kinase; TIGRFAM: cytidylate kinase; PFAM: cytidylate kinase region.


ensembl_gene_id: Spro_1709
symbol: Spro_1709
gene_biotype: protein_coding
description:
  Ribosomal protein S1; Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence.


ensembl_gene_id: Spro_1710
symbol: ihfB
gene_biotype: protein_coding
description:
  Integration host factor, beta subunit; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family.


ensembl_gene_id: Spro_1711
symbol: Spro_1711
gene_biotype: protein_coding
description:
  TIGRFAM: DNA internalization-related competence protein ComEC/Rec2; PFAM: beta-lactamase domain protein; ComEC/Rec2-related protein; KEGG: yen:YE1542 hypothetical protein.


ensembl_gene_id: Spro_1712
symbol: msbA
gene_biotype: protein_coding
description:
  Lipid A ABC exporter, fused ATPase and inner membrane subunits MsbA; Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.


ensembl_gene_id: Spro_1713
symbol: lpxK
gene_biotype: protein_coding
description:
  Tetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).


ensembl_gene_id: Spro_1715
symbol: Spro_1715
gene_biotype: protein_coding
description:
  PFAM: Cold-shock protein DNA-binding; SMART: Cold shock protein; KEGG: yen:YE1546 putative cold shock protein CspE2.


ensembl_gene_id: Spro_1716
symbol: Spro_1716
gene_biotype: protein_coding
description:
  PFAM: Cold-shock protein DNA-binding; SMART: Cold shock protein; KEGG: ypi:YpsIP31758_2574 cold shock DNA-binding domain protein.


ensembl_gene_id: Spro_1718
symbol: Spro_1718
gene_biotype: protein_coding
description:
  PFAM: protein of unknown function DUF343; KEGG: ypi:YpsIP31758_2572 hypothetical protein; Belongs to the UPF0434 family.


ensembl_gene_id: Spro_1719
symbol: kdsB
gene_biotype: protein_coding
description:
  3-deoxy-D-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.


ensembl_gene_id: Spro_1722
symbol: cmoM
gene_biotype: protein_coding
description:
  Methyltransferase type 11; Catalyzes the methylation of 5-carboxymethoxyuridine (cmo5U) to form 5-methoxycarbonylmethoxyuridine (mcmo5U) at position 34 in tRNAs; Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoM family.


ensembl_gene_id: Spro_1723
symbol: mukF
gene_biotype: protein_coding
description:
  Chromosome segregation and condensation protein MukF; Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity.


ensembl_gene_id: Spro_1724
symbol: mukE
gene_biotype: protein_coding
description:
  Chromosome segregation and condensation protein MukE; Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF.


ensembl_gene_id: Spro_1725
symbol: mukB
gene_biotype: protein_coding
description:
  Chromosome segregation and condensation protein MukB domain protein; Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division; Belongs to the SMC family. MukB subfamily.


ensembl_gene_id: Spro_1728
symbol: Spro_1728
gene_biotype: protein_coding
description:
  PFAM: beta-lactamase domain protein; KEGG: ypi:YpsIP31758_2561 metallo-beta-lactamase family protein.


ensembl_gene_id: Spro_1729
symbol: Spro_1729
gene_biotype: protein_coding
description:
  Aspartate transaminase; PFAM: aminotransferase class I and II; KEGG: yen:YE1561 aspartate aminotransferase.


ensembl_gene_id: Spro_1730
symbol: Spro_1730
gene_biotype: protein_coding
description:
  PFAM: porin Gram-negative type; KEGG: stm:STM1473 outer membrane protein N precursor; Belongs to the Gram-negative porin family.


ensembl_gene_id: Spro_1731
symbol: asnS
gene_biotype: protein_coding
description:
  TIGRFAM: asparaginyl-tRNA synthetase; PFAM: tRNA synthetase class II (D K and N); nucleic acid binding OB-fold tRNA/helicase-type; KEGG: yen:YE1564 asparaginyl-tRNA synthetase.


ensembl_gene_id: Spro_1732
symbol: pncB
gene_biotype: protein_coding
description:
  Nicotinate phosphoribosyltransferase; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family.


ensembl_gene_id: Spro_1733
symbol: Spro_1733
gene_biotype: protein_coding
description:
  TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; KEGG: sun:SUN_1205 signal transduction response regulator.


ensembl_gene_id: Spro_1734
symbol: Spro_1734
gene_biotype: protein_coding
description:
  TIGRFAM: aminopeptidase N; PFAM: Peptidase M1 membrane alanine aminopeptidase; KEGG: yps:YPTB1438 putative aminopeptidase N.


ensembl_gene_id: Spro_1735
symbol: ssuB
gene_biotype: protein_coding
description:
  ABC transporter-related protein; Part of the ABC transporter complex SsuABC involved in aliphatic sulfonates import. Responsible for energy coupling to the transport system.


ensembl_gene_id: Spro_1736
symbol: Spro_1736
gene_biotype: protein_coding
description:
  PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: ypi:YpsIP31758_0355 putative ABC aliphatic sulfonates transporter, permease subunit.


ensembl_gene_id: Spro_1737
symbol: ssuD
gene_biotype: protein_coding
description:
  Alkanesulfonate monooxygenase; Catalyzes the desulfonation of aliphatic sulfonates. Belongs to the SsuD family.


ensembl_gene_id: Spro_1738
symbol: Spro_1738
gene_biotype: protein_coding
description:
  TIGRFAM: aliphatic sulfonates family ABC transporter, periplsmic ligand-binding protein; SMART: extracellular solute-binding protein family 3; KEGG: ypi:YpsIP31758_0353 putative ABC transporter, aliphatic sulfonates binding protein.


ensembl_gene_id: Spro_1740
symbol: pyrD
gene_biotype: protein_coding
description:
  Dihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.


ensembl_gene_id: Spro_1741
symbol: zapC
gene_biotype: protein_coding
description:
  Protein of unknown function DUF1379; Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ.


ensembl_gene_id: Spro_1742
symbol: Spro_1742
gene_biotype: protein_coding
description:
  PFAM: ferredoxin; MOSC domain containing protein; MOSC domain protein beta barrel domain protein; KEGG: yen:YE1570 putative iron-sulfur binding protein.


ensembl_gene_id: Spro_1743
symbol: rlmL
gene_biotype: protein_coding
description:
  Putative RNA methylase; Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA. Belongs to the methyltransferase superfamily. RlmKL family.


ensembl_gene_id: Spro_1744
symbol: Spro_1744
gene_biotype: protein_coding
description:
  PFAM: SMC domain protein; ABC transporter related; SMART: AAA ATPase; KEGG: yen:YE1572 ABC transporter ATP-binding protein.


ensembl_gene_id: Spro_1745
symbol: Spro_1745
gene_biotype: protein_coding
description:
  TIGRFAM: integral membrane protein, PqiA family; PFAM: Paraquat-inducible protein A; KEGG: yen:YE1573 putative paraquat-inducible protein A.


ensembl_gene_id: Spro_1748
symbol: rmf
gene_biotype: protein_coding
description:
  Ribosome modulation factor; During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes); Belongs to the ribosome modulation factor family.


ensembl_gene_id: Spro_1749
symbol: Spro_1749
gene_biotype: protein_coding
description:
  Beta-ketoacyl synthase; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.


ensembl_gene_id: Spro_1750
symbol: Spro_1750
gene_biotype: protein_coding
description:
  Transcriptional regulator, HxlR family; PFAM: helix-turn-helix HxlR type; KEGG: yen:YE1577 hypothetical protein.


ensembl_gene_id: Spro_1751
symbol: fabA
gene_biotype: protein_coding
description:
  Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabA; Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E- (2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length.


ensembl_gene_id: Spro_1753
symbol: matP
gene_biotype: protein_coding
description:
  Protein of unknown function DUF1047; Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain.


ensembl_gene_id: Spro_1754
symbol: Spro_1754
gene_biotype: protein_coding
description:
  PFAM: OmpA domain protein transmembrane region-containing protein; OmpA/MotB domain protein; KEGG: sgl:SG1030 outer membrane protein A precursor; Belongs to the outer membrane OOP (TC 1.B.6) superfamily.


ensembl_gene_id: Spro_1755
symbol: sulA
gene_biotype: protein_coding
description:
  Cell division inhibitor SulA; Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division.


ensembl_gene_id: Spro_1756
symbol: Spro_1756
gene_biotype: protein_coding
description:
  Regulator of competence-specific genes; PFAM: TfoX domain protein; KEGG: yen:YE1583 hypothetical protein.


ensembl_gene_id: Spro_1757
symbol: Spro_1757
gene_biotype: protein_coding
description:
  TIGRFAM: hypothetical membrane protein; integral membrane protein, YccS/YhfK family; PFAM: protein of unknown function DUF893 YccS/YhfK; KEGG: yen:YE1584 hypothetical protein.


ensembl_gene_id: Spro_1763
symbol: hspQ
gene_biotype: protein_coding
description:
  Hemimethylated DNA binding protein; Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress; Belongs to the HspQ family.


ensembl_gene_id: Spro_1764
symbol: rlmI
gene_biotype: protein_coding
description:
  PUA domain containing protein; Specifically methylates the cytosine at position 1962 (m5C1962) of 23S rRNA.


ensembl_gene_id: Spro_1767
symbol: Spro_1767
gene_biotype: protein_coding
description:
  PFAM: protein of unknown function UPF0005; KEGG: eca:ECA1763 putative membrane protein; Belongs to the BI1 family.


ensembl_gene_id: Spro_1772
symbol: Spro_1772
gene_biotype: protein_coding
description:
  PFAM: DNA repair protein RadC; KEGG: yps:YPTB3868 hypothetical protein; Belongs to the UPF0758 family.


ensembl_gene_id: Spro_1775
symbol: Spro_1775
gene_biotype: protein_coding
description:
  TIGRFAM: lipopolysaccharide heptosyltransferase III, putative; PFAM: glycosyl transferase family 9; KEGG: ypp:YPDSF_3215 lipopolysaccharide core biosynthesis protein.


ensembl_gene_id: Spro_1783
symbol: Spro_1783
gene_biotype: protein_coding
description:
  PFAM: conserved hypothetical protein; KEGG: ent:Ent638_2916 uncharacterised conserved protein UCP028301.


ensembl_gene_id: Spro_1789
symbol: Spro_1789
gene_biotype: protein_coding
description:
  PFAM: AAA ATPase central domain protein; ATPase associated with various cellular activities AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; KEGG: kpn:KPN_01328 putative protease; Belongs to the ClpA/ClpB family.


ensembl_gene_id: Spro_1798
symbol: Spro_1798
gene_biotype: protein_coding
description:
  PFAM: ImcF domain protein; protein of unknown function DUF1215; KEGG: kpn:KPN_01342 hypothetical protein.


ensembl_gene_id: Spro_1805
symbol: Spro_1805
gene_biotype: protein_coding
description:
  TIGRFAM: choline/carnitine/betaine transporter; PFAM: BCCT transporter; KEGG: kpn:KPN_pKPN3p05958 secondary glycine betaine transporter BetU; Belongs to the BCCT transporter (TC 2.A.15) family.


ensembl_gene_id: Spro_1807
symbol: Spro_1807
gene_biotype: protein_coding
description:
  Gluconate 2-dehydrogenase (acceptor); PFAM: cytochrome c class I; KEGG: yen:YE1369 putative dehydrogenase, cytochrome c subunit.


ensembl_gene_id: Spro_1810
symbol: Spro_1810
gene_biotype: protein_coding
description:
  Nuclease; PFAM: DNA/RNA non-specific endonuclease; KEGG: ypi:YpsIP31758_B0090 putative endonuclease.


ensembl_gene_id: Spro_1813
symbol: Spro_1813
gene_biotype: protein_coding
description:
  TIGRFAM: flavoprotein WrbA; PFAM: NADPH-dependent FMN reductase; flavodoxin/nitric oxide synthase; KEGG: ypi:YpsIP31758_2261 flavoprotein WrbA.


ensembl_gene_id: Spro_1815
symbol: Spro_1815
gene_biotype: protein_coding
description:
  Transcriptional regulator, LysR family; PFAM: regulatory protein LysR; LysR substrate-binding; KEGG: pfl:PFL_4583 CDA peptide synthetase I.


ensembl_gene_id: Spro_1816
symbol: Spro_1816
gene_biotype: protein_coding
description:
  Transcriptional regulator, XRE family; PFAM: helix-turn-helix domain protein; Cupin 2 conserved barrel domain protein; KEGG: ppf:Pput_3508 transcriptional regulator, XRE family.


ensembl_gene_id: Spro_1818
symbol: Spro_1818
gene_biotype: protein_coding
description:
  TIGRFAM: uracil-xanthine permease; PFAM: Xanthine/uracil/vitamin C permease; KEGG: yen:YE1944 putative membrane permease.


ensembl_gene_id: Spro_1819
symbol: rutF
gene_biotype: protein_coding
description:
  Flavin reductase domain protein FMN-binding; Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway; Belongs to the non-flavoprotein flavin reductase family. RutF subfamily.


ensembl_gene_id: Spro_1820
symbol: rutD
gene_biotype: protein_coding
description:
  Alpha/beta hydrolase fold; May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation. Belongs to the AB hydrolase superfamily. Hydrolase RutD family.


ensembl_gene_id: Spro_1821
symbol: rutC
gene_biotype: protein_coding
description:
  Endoribonuclease L-PSP; May reduce aminoacrylate peracid to aminoacrylate. Required to remove a toxic intermediate produce by the pyrimidine nitrogen degradation.


ensembl_gene_id: Spro_1822
symbol: rutB
gene_biotype: protein_coding
description:
  Isochorismatase hydrolase; In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2; Belongs to the isochorismatase family. RutB subfamily.


ensembl_gene_id: Spro_1823
symbol: rutA
gene_biotype: protein_coding
description:
  Luciferase family protein; Catalyzes the pyrimidine ring opening between N-3 and C-4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate.


ensembl_gene_id: Spro_1824
symbol: Spro_1824
gene_biotype: protein_coding
description:
  PFAM: regulatory protein TetR; Tetracycline transcriptional regulator YcdC domain protein; KEGG: yen:YE1951 putative TetR-family transcriptional regulatory protein.


ensembl_gene_id: Spro_1825
symbol: Spro_1825
gene_biotype: protein_coding
description:
  PFAM: amino acid permease-associated region; KEGG: yen:YE1952 D-serine/D-alanine/glycine transporter.


ensembl_gene_id: Spro_1828
symbol: Spro_1828
gene_biotype: protein_coding
description:
  PFAM: Enoyl-CoA hydratase/isomerase; KEGG: sma:SAV1350 putative enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family.


ensembl_gene_id: Spro_1829
symbol: Spro_1829
gene_biotype: protein_coding
description:
  PFAM: major facilitator superfamily MFS_1; KEGG: rru:Rru_A0797 major facilitator transporter superfamily MFS_1.


ensembl_gene_id: Spro_1830
symbol: Spro_1830
gene_biotype: protein_coding
description:
  KEGG: pla:Plav_2905 5-aminolevulinic acid synthase; TIGRFAM: 5-aminolevulinic acid synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; aminotransferase class I and II.


ensembl_gene_id: Spro_1831
symbol: Spro_1831
gene_biotype: protein_coding
description:
  TIGRFAM: acetyl-CoA acetyltransferase; PFAM: Thiolase; KEGG: csa:Csal_0301 beta-ketoadipyl CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.


ensembl_gene_id: Spro_1832
symbol: Spro_1832
gene_biotype: protein_coding
description:
  PFAM: 3-hydroxyacyl-CoA dehydrogenase domain protein; 3-hydroxyacyl-CoA dehydrogenase NAD-binding; KEGG: pin:Ping_0657 3-hydroxybutyryl-CoA dehydrogenase.


ensembl_gene_id: Spro_1833
symbol: Spro_1833
gene_biotype: protein_coding
description:
  Transcriptional regulator, LuxR family; PFAM: regulatory protein LuxR; Autoinducer-binding domain protein; KEGG: bvi:Bcep1808_6456 autoinducer-binding domain protein.


ensembl_gene_id: Spro_1835
symbol: Spro_1835
gene_biotype: protein_coding
description:
  PFAM: Malate/L-lactate dehydrogenase; KEGG: kpn:KPN_04791 putative dehydrogenase; Belongs to the LDH2/MDH2 oxidoreductase family.


ensembl_gene_id: Spro_1838
symbol: Spro_1838
gene_biotype: protein_coding
description:
  PFAM: dihydrodipicolinate synthetase; KEGG: bch:Bcen2424_4139 dihydrodipicolinate synthetase; Belongs to the DapA family.


ensembl_gene_id: Spro_1839
symbol: Spro_1839
gene_biotype: protein_coding
description:
  Transcriptional regulator, AraC family; PFAM: helix-turn-helix- domain containing protein AraC type; PAS fold-4 domain protein; KEGG: plu:plu2244 hypothetical protein.


ensembl_gene_id: Spro_1843
symbol: Spro_1843
gene_biotype: protein_coding
description:
  PFAM: BFD domain protein [2Fe-2S]-binding domain protein; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: bur:Bcep18194_B1891 pyridine nucleotide-disulphide oxidoreductase.


ensembl_gene_id: Spro_1848
symbol: Spro_1848
gene_biotype: protein_coding
description:
  Two component transcriptional regulator, LuxR family; PFAM: regulatory protein LuxR; response regulator receiver; KEGG: yen:YE1831 response regulator protein.


ensembl_gene_id: Spro_1849
symbol: uvrC
gene_biotype: protein_coding
description:
  Excinuclease ABC, C subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.


ensembl_gene_id: Spro_1850
symbol: pgsA
gene_biotype: protein_coding
description:
  CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; This protein catalyzes the committed step to the synthesis of the acidic phospholipids; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.


ensembl_gene_id: Spro_1852
symbol: Spro_1852
gene_biotype: protein_coding
description:
  Transcriptional regulator, XRE family; SMART: helix-turn-helix domain protein; KEGG: plu:plu2536 hypothetical protein.


ensembl_gene_id: Spro_1854
symbol: Spro_1854
gene_biotype: protein_coding
description:
  Transcriptional regulator, RpiR family; PFAM: helix-turn-helix protein RpiR; sugar isomerase (SIS); KEGG: pfo:Pfl_0722 transcriptional regulator, RpiR family.


ensembl_gene_id: Spro_1855
symbol: Spro_1855
gene_biotype: protein_coding
description:
  PFAM: phosphotransferase system lactose/cellobiose-specific IIB subunit; KEGG: plu:plu2754 PTS system, cellobiose-specific IIB component.


ensembl_gene_id: Spro_1856
symbol: Spro_1856
gene_biotype: protein_coding
description:
  PFAM: phosphotransferase system PTS lactose/cellobiose-specific IIA subunit; KEGG: kpn:KPN_04368 putative PEP-dependent phosphotransferase enzyme III.


ensembl_gene_id: Spro_1860
symbol: Spro_1860
gene_biotype: protein_coding
description:
  TIGRFAM: metabolite/H+ symporter, major facilitator superfamily (MFS); PFAM: General substrate transporter; major facilitator superfamily MFS_1; Osmosensory transporter coiled coil; KEGG: yen:YE3594 proline/betaine transporter.


ensembl_gene_id: Spro_1861
symbol: Spro_1861
gene_biotype: protein_coding
description:
  TIGRFAM: RND efflux system, outer membrane lipoprotein, NodT family; PFAM: outer membrane efflux protein; KEGG: ppd:Ppro_2218 RND efflux system, outer membrane lipoprotein, NodT family.


ensembl_gene_id: Spro_1863
symbol: Spro_1863
gene_biotype: protein_coding
description:
  TIGRFAM: efflux transporter, RND family, MFP subunit; PFAM: secretion protein HlyD family protein; KEGG: sgl:SG1458 putative secretion protein; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.


ensembl_gene_id: Spro_1867
symbol: nhaP2
gene_biotype: protein_coding
description:
  Sodium/hydrogen exchanger; K(+)/H(+) antiporter that extrudes potassium in exchange for external protons and maintains the internal concentration of potassium under toxic levels; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. NhaP2 subfamily.


ensembl_gene_id: Spro_1869
symbol: mdoC
gene_biotype: protein_coding
description:
  Acyltransferase 3; Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane.


ensembl_gene_id: Spro_1870
symbol: mdoG
gene_biotype: protein_coding
description:
  Periplasmic glucan biosynthesis protein MdoG; Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs).


ensembl_gene_id: Spro_1871
symbol: mdoH
gene_biotype: protein_coding
description:
  Glycosyl transferase family 2; Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs).


ensembl_gene_id: Spro_1875
symbol: leuA-2
gene_biotype: protein_coding
description:
  2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.


ensembl_gene_id: Spro_1876
symbol: Spro_1876
gene_biotype: protein_coding
description:
  Transcriptional regulator, AraC family; PFAM: helix-turn-helix- domain containing protein AraC type; AraC protein arabinose-binding/dimerisation; KEGG: ent:Ent638_3166 transcriptional regulator, AraC family.


ensembl_gene_id: Spro_1881
symbol: Spro_1881
gene_biotype: protein_coding
description:
  KEGG: ent:Ent638_0823 amino acid/peptide transporter; TIGRFAM: amino acid/peptide transporter; PFAM: TGF-beta receptor type I/II extracellular region; major facilitator superfamily MFS_1.


ensembl_gene_id: Spro_1884
symbol: lpxL
gene_biotype: protein_coding
description:
  Lipid A biosynthesis lauroyl (or palmitoleoyl) acyltransferase; Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(lauroyl)-lipid IV(A).


ensembl_gene_id: Spro_1885
symbol: Spro_1885
gene_biotype: protein_coding
description:
  NADH:flavin oxidoreductase Old Yellow Enzyme family-like protein; KEGG: eca:ECA1780 putative NADH-dependent flavin oxidoreductase.


ensembl_gene_id: Spro_1886
symbol: Spro_1886
gene_biotype: protein_coding
description:
  PFAM: Rhodanese domain protein; KEGG: ypi:YpsIP31758_1560 rhodanese domain protein; Belongs to the UPF0176 family.


ensembl_gene_id: Spro_1892
symbol: solA
gene_biotype: protein_coding
description:
  Sarcosine oxidase; Catalyzes the oxidative demethylation of N-methyl-L- tryptophan; Belongs to the MSOX/MTOX family. MTOX subfamily.


ensembl_gene_id: Spro_1896
symbol: pyrC
gene_biotype: protein_coding
description:
  Dihydroorotase, homodimeric type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.


ensembl_gene_id: Spro_1898
symbol: rne
gene_biotype: protein_coding
description:
  Ribonuclease, Rne/Rng family; Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs. Belongs to the RNase E/G family. RNase E subfamily.


ensembl_gene_id: Spro_1900
symbol: Spro_1900
gene_biotype: protein_coding
description:
  Maf protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes 7- methyl-GTP (m(7)GTP). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids; Belongs to the Maf family. YceF subfamily.


ensembl_gene_id: Spro_1902
symbol: rpmF
gene_biotype: protein_coding
description:
  TIGRFAM: ribosomal protein L32; PFAM: ribosomal L32p protein; KEGG: ypi:YpsIP31758_1574 ribosomal protein L32; Belongs to the bacterial ribosomal protein bL32 family.


ensembl_gene_id: Spro_1903
symbol: plsX
gene_biotype: protein_coding
description:
  Fatty acid/phospholipid synthesis protein PlsX; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.


ensembl_gene_id: Spro_1904
symbol: fabH
gene_biotype: protein_coding
description:
  3-oxoacyl-(acyl-carrier-protein) synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family.


ensembl_gene_id: Spro_1905
symbol: Spro_1905
gene_biotype: protein_coding
description:
  TIGRFAM: malonyl CoA-acyl carrier protein transacylase; PFAM: Acyl transferase; KEGG: yen:YE1634 malonyl CoA-acyl carrier protein transacylase.


ensembl_gene_id: Spro_1906
symbol: Spro_1906
gene_biotype: protein_coding
description:
  3-oxoacyl-(acyl-carrier-protein) reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family.


ensembl_gene_id: Spro_1910
symbol: mltG
gene_biotype: protein_coding
description:
  Aminodeoxychorismate lyase; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.


ensembl_gene_id: Spro_1911
symbol: tmk
gene_biotype: protein_coding
description:
  dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.


ensembl_gene_id: Spro_1912
symbol: Spro_1912
gene_biotype: protein_coding
description:
  KEGG: yps:YPTB2465 DNA polymerase III, delta' subunit; TIGRFAM: DNA polymerase III, delta prime subunit; PFAM: DNA polymerase III delta subunit.


ensembl_gene_id: Spro_1913
symbol: Spro_1913
gene_biotype: protein_coding
description:
  TIGRFAM: hydrolase, TatD family; PFAM: TatD-related deoxyribonuclease; KEGG: yen:YE1642 putative deoxyribonuclease.


ensembl_gene_id: Spro_1914
symbol: Spro_1914
gene_biotype: protein_coding
description:
  TIGRFAM: PTS system, maltose and glucose-specific subfamily, IIC subunit; PTS system, glucose-specific IIBC subunit; PTS system, glucose-like IIB subunint; PFAM: phosphotransferase system PTS EIIB protein; phosphotransferase system EIIC; KEGG: yen:YE1643 PTS system, glucose-specific IIBC component.


ensembl_gene_id: Spro_1915
symbol: Spro_1915
gene_biotype: protein_coding
description:
  Iron (metal) dependent repressor, DtxR family; PFAM: iron dependent repressor; Helix-turn-helix type 11 domain protein; KEGG: rpb:RPB_3400 iron dependent repressor.


ensembl_gene_id: Spro_1916
symbol: mntH
gene_biotype: protein_coding
description:
  Mn2+/Fe2+ transporter, NRAMP family; H(+)-stimulated, divalent metal cation uptake system. Belongs to the NRAMP family.


ensembl_gene_id: Spro_1917
symbol: Spro_1917
gene_biotype: protein_coding
description:
  PFAM: short-chain dehydrogenase/reductase SDR; KR domain protein; KEGG: yen:YE3354 putative oxidoreductase.


ensembl_gene_id: Spro_1919
symbol: Spro_1919
gene_biotype: protein_coding
description:
  PFAM: extracellular solute-binding protein family 3; KEGG: eca:ECA2157 ABC transporter, substrate binding protein.


ensembl_gene_id: Spro_1920
symbol: Spro_1920
gene_biotype: protein_coding
description:
  PFAM: histidine triad (HIT) protein; KEGG: ypi:YpsIP31758_1588 histidine triad nucleotide-binding protein HinT.


ensembl_gene_id: Spro_1922
symbol: lpoB
gene_biotype: protein_coding
description:
  Membrane lipoprotein lipid attachment site; Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b).


ensembl_gene_id: Spro_1924
symbol: nagZ
gene_biotype: protein_coding
description:
  Glycoside hydrolase family 3 domain protein; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.


ensembl_gene_id: Spro_1925
symbol: Spro_1925
gene_biotype: protein_coding
description:
  PFAM: protein of unknown function UPF0227; KEGG: ypi:YpsIP31758_1593 hypothetical protein; Belongs to the UPF0227 family.


ensembl_gene_id: Spro_1926
symbol: Spro_1926
gene_biotype: protein_coding
description:
  PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; KEGG: yen:YE1707 NADH dehydrogenase.


ensembl_gene_id: Spro_1928
symbol: Spro_1928
gene_biotype: protein_coding
description:
  Transcriptional regulator, BadM/Rrf2 family; PFAM: protein of unknown function UPF0074; KEGG: kpn:KPN_02971 putative transcriptional regulator.


ensembl_gene_id: Spro_1929
symbol: Spro_1929
gene_biotype: protein_coding
description:
  TIGRFAM: transporter, hydrophobe/amphiphile efflux-1 (HAE1) family; PFAM: acriflavin resistance protein; KEGG: kpn:KPN_02970 integral transmembrane protein; acridine resistance.


ensembl_gene_id: Spro_1930
symbol: Spro_1930
gene_biotype: protein_coding
description:
  TIGRFAM: efflux transporter, RND family, MFP subunit; PFAM: secretion protein HlyD family protein; KEGG: ent:Ent638_1891 efflux transporter, RND family, MFP subunit; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.


ensembl_gene_id: Spro_1931
symbol: Spro_1931
gene_biotype: protein_coding
description:
  Transcriptional regulator, AraC family; PFAM: helix-turn-helix- domain containing protein AraC type; KEGG: kpn:KPN_02968 putative helix-turn-helix, AraC type.


ensembl_gene_id: Spro_1932
symbol: Spro_1932
gene_biotype: protein_coding
description:
  Amino acid/peptide transporter; KEGG: lpc:LPC_0954 peptide transport protein; TIGRFAM: amino acid/peptide transporter; PFAM: TGF-beta receptor type I/II extracellular region; major facilitator superfamily MFS_1.


ensembl_gene_id: Spro_1933
symbol: ghrA
gene_biotype: protein_coding
description:
  D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively.


ensembl_gene_id: Spro_1934
symbol: Spro_1934
gene_biotype: protein_coding
description:
  PFAM: PHP domain protein; SMART: phosphoesterase PHP domain protein; KEGG: ypi:YpsIP31758_2053 putative phosphoesterase; Belongs to the PHP family.


ensembl_gene_id: Spro_1937
symbol: Spro_1937
gene_biotype: protein_coding
description:
  Oligopeptidase B; PFAM: peptidase S9 prolyl oligopeptidase active site domain protein; peptidase S9A prolyl oligopeptidase domain protein beta-propeller; KEGG: yen:YE1789 oligopeptidase B.


ensembl_gene_id: Spro_1938
symbol: Spro_1938
gene_biotype: protein_coding
description:
  PFAM: Exonuclease RNase T and DNA polymerase III; SMART: Exonuclease; KEGG: yen:YE1790 putative exodeoxyribonuclease.


ensembl_gene_id: Spro_1939
symbol: Spro_1939
gene_biotype: protein_coding
description:
  Transcriptional regulator, TraR/DksA family; TIGRFAM: RNA polymerase-binding protein DksA; PFAM: zinc finger DksA/TraR C4-type; KEGG: pap:PSPA7_6338 RNA polymerase-binding protein DksA.


ensembl_gene_id: Spro_1940
symbol: Spro_1940
gene_biotype: protein_coding
description:
  KEGG: ypp:YPDSF_1342 proline iminopeptidase; TIGRFAM: proline iminopeptidase; PFAM: alpha/beta hydrolase fold; Belongs to the peptidase S33 family.


ensembl_gene_id: Spro_1946
symbol: Spro_1946
gene_biotype: protein_coding
description:
  PFAM: GCN5-related N-acetyltransferase; KEGG: kpn:KPN_00583 putative GCN5-related N-acetyltransferase.


ensembl_gene_id: Spro_1949
symbol: fabV
gene_biotype: protein_coding
description:
  Trans-2-enoyl-CoA reductase (NAD(+)); Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon- carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP); Belongs to the TER reductase family.


ensembl_gene_id: Spro_1951
symbol: Spro_1951
gene_biotype: protein_coding
description:
  Transcriptional regulator, XRE family; PFAM: helix-turn-helix domain protein; KEGG: rpe:RPE_4746 transcriptional regulator, XRE family.


ensembl_gene_id: Spro_1955
symbol: Spro_1955
gene_biotype: protein_coding
description:
  Transcriptional regulator, LysR family; PFAM: regulatory protein LysR; LysR substrate-binding; KEGG: pap:PSPA7_4416 transcriptional regulator, LysR family.


ensembl_gene_id: Spro_1956
symbol: Spro_1956
gene_biotype: protein_coding
description:
  PFAM: Alcohol dehydrogenase zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein; KEGG: pap:PSPA7_4414 aryl-alcohol dehydrogenase (benzyl alcoholdehydrogenase) (badh).


ensembl_gene_id: Spro_1958
symbol: Spro_1958
gene_biotype: protein_coding
description:
  Response regulator receiver and unknown domain protein; PFAM: response regulator receiver; KEGG: eca:ECA4398 two-component response regulator.


ensembl_gene_id: Spro_1959
symbol: Spro_1959
gene_biotype: protein_coding
description:
  Signal transduction histidine kinase regulating citrate/malate metabolism; PFAM: ATP-binding region ATPase domain protein; PAS fold domain protein; KEGG: yen:YE2505 two-component system, sensor kinase.


ensembl_gene_id: Spro_1960
symbol: Spro_1960
gene_biotype: protein_coding
description:
  PFAM: deoxyribose-phosphate aldolase/phospho-2-dehydro-3-deoxyheptonate aldolase; KEGG: sme:SMb20498 hypothetical protein.


ensembl_gene_id: Spro_1961
symbol: Spro_1961
gene_biotype: protein_coding
description:
  PFAM: periplasmic binding protein/LacI transcriptional regulator; KEGG: kpn:KPN_00509 putative periplasmic binding protein.


ensembl_gene_id: Spro_1963
symbol: Spro_1963
gene_biotype: protein_coding
description:
  Monosaccharide-transporting ATPase; PFAM: inner-membrane translocator; KEGG: kpn:KPN_00511 putative bacterial inner-membrane translocator; Belongs to the binding-protein-dependent transport system permease family.


ensembl_gene_id: Spro_1964
symbol: Spro_1964
gene_biotype: protein_coding
description:
  PFAM: periplasmic binding protein/LacI transcriptional regulator; KEGG: hch:HCH_01166 ABC-type sugar transport system, periplasmic component.


ensembl_gene_id: Spro_1966
symbol: Spro_1966
gene_biotype: protein_coding
description:
  TIGRFAM: lipoprotein, YaeC family; PFAM: NLPA lipoprotein; KEGG: spt:SPA0252 putative lipoprotein precursor; Belongs to the nlpA lipoprotein family.


ensembl_gene_id: Spro_1972
symbol: Spro_1972
gene_biotype: protein_coding
description:
  Transcriptional regulator, LacI family; PFAM: regulatory protein LacI; periplasmic binding protein/LacI transcriptional regulator; KEGG: ecj:JW3046 DNA-binding transcriptional repressor.


ensembl_gene_id: Spro_1973
symbol: Spro_1973
gene_biotype: protein_coding
description:
  PFAM: glycoside hydrolase family 42 domain 5 loop region; glycoside hydrolase family 2 immunoglobulin domain protein beta-sandwich; glycoside hydrolase family 2 TIM barrel; glycoside hydrolase family 2 sugar binding; KEGG: aha:AHA_0205 evolved beta-galactosidase alpha-subunit.


ensembl_gene_id: Spro_1974
symbol: Spro_1974
gene_biotype: protein_coding
description:
  PFAM: conserved hypothetical protein; KEGG: vvy:VV2643 evolved beta-D-galactosidase, beta subunit; cryptic gene.


ensembl_gene_id: Spro_1978
symbol: clpP-2
gene_biotype: protein_coding
description:
  Endopeptidase Clp; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.


ensembl_gene_id: Spro_1982
symbol: ychF
gene_biotype: protein_coding
description:
  GTP-binding protein YchF; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.


ensembl_gene_id: Spro_1983
symbol: Spro_1983
gene_biotype: protein_coding
description:
  PFAM: Sulfate transporter/antisigma-factor antagonist STAS; Xanthine/uracil/vitamin C permease; sulphate transporter; KEGG: nis:NIS_1014 sulfate transporter.


ensembl_gene_id: Spro_1984
symbol: pth
gene_biotype: protein_coding
description:
  Aminoacyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family.


ensembl_gene_id: Spro_1986
symbol: prs
gene_biotype: protein_coding
description:
  Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.


ensembl_gene_id: Spro_1987
symbol: ispE
gene_biotype: protein_coding
description:
  4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol; Belongs to the GHMP kinase family. IspE subfamily.


ensembl_gene_id: Spro_1988
symbol: lolB
gene_biotype: protein_coding
description:
  Outer membrane lipoprotein LolB; Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein.


ensembl_gene_id: Spro_1989
symbol: hemA
gene_biotype: protein_coding
description:
  glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).


ensembl_gene_id: Spro_1990
symbol: prfA
gene_biotype: protein_coding
description:
  Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.


ensembl_gene_id: Spro_1991
symbol: prmC
gene_biotype: protein_coding
description:
  Modification methylase, HemK family; Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif; Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.


ensembl_gene_id: Spro_1994
symbol: kdsA
gene_biotype: protein_coding
description:
  TIGRFAM: 2-dehydro-3-deoxyphosphooctonate aldolase; PFAM: DAHP synthetase I/KDSA; KEGG: ypi:YpsIP31758_2062 3-deoxy-8-phosphooctulonate synthase.


ensembl_gene_id: Spro_1995
symbol: Spro_1995
gene_biotype: protein_coding
description:
  TIGRFAM: sulfate transporter; PFAM: Sulfate transporter/antisigma-factor antagonist STAS; Xanthine/uracil/vitamin C permease; sulphate transporter; KEGG: yen:YE2426 hypothetical protein.


ensembl_gene_id: Spro_1996
symbol: Spro_1996
gene_biotype: protein_coding
description:
  PFAM: protein of unknown function DUF336; KEGG: yen:YE1367 hypothetical protein; Belongs to the UPF0303 family.


ensembl_gene_id: Spro_1997
symbol: Spro_1997
gene_biotype: protein_coding
description:
  TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; KEGG: yen:YE2425 putative inner membrane protein.


ensembl_gene_id: Spro_1998
symbol: mfd
gene_biotype: protein_coding
description:
  Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily.


ensembl_gene_id: Spro_1999
symbol: Spro_1999
gene_biotype: protein_coding
description:
  PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; KEGG: pol:Bpro_3215 pyridoxal-5'-phosphate-dependent enzyme, beta subunit.


ensembl_gene_id: Spro_2001
symbol: Spro_2001
gene_biotype: protein_coding
description:
  TIGRFAM: lipoprotein releasing system, transmembrane protein, LolC/E family; PFAM: protein of unknown function DUF214; KEGG: stm:STM1217.S integral membrane protein.


ensembl_gene_id: Spro_2002
symbol: lolD
gene_biotype: protein_coding
description:
  Lipoprotein releasing system, ATP-binding protein; Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.


ensembl_gene_id: Spro_2003
symbol: Spro_2003
gene_biotype: protein_coding
description:
  TIGRFAM: lipoprotein releasing system, transmembrane protein, LolC/E family; lipoprotein releasing system, transmembrane protein LolE; PFAM: protein of unknown function DUF214; KEGG: ent:Ent638_1633 lipoprotein releasing system, transmembrane protein LolE.


ensembl_gene_id: Spro_2004
symbol: nagK
gene_biotype: protein_coding
description:
  ROK family protein; Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P.


ensembl_gene_id: Spro_2005
symbol: cobB
gene_biotype: protein_coding
description:
  PFAM: Silent information regulator protein Sir2; KEGG: yen:YE1714 putative Sir2 family protein; Belongs to the sirtuin family. Class III subfamily.


ensembl_gene_id: Spro_2006
symbol: Spro_2006
gene_biotype: protein_coding
description:
  Transcriptional regulator, RpiR family; PFAM: helix-turn-helix protein RpiR; sugar isomerase (SIS); KEGG: kpn:KPN_04017 putative sugar isomerase.


ensembl_gene_id: Spro_2008
symbol: Spro_2008
gene_biotype: protein_coding
description:
  TIGRFAM: PTS system, glucose-like IIB subunint; PFAM: phosphotransferase system PTS EIIB protein; phosphotransferase system EIIC; KEGG: kpn:KPN_04015 phosphotransferase system PTS.


ensembl_gene_id: Spro_2009
symbol: pepT
gene_biotype: protein_coding
description:
  Peptidase T; Cleaves the N-terminal amino acid of tripeptides. Belongs to the peptidase M20B family.


ensembl_gene_id: Spro_2010
symbol: Spro_2010
gene_biotype: protein_coding
description:
  PFAM: Malate/L-lactate dehydrogenase; KEGG: ecv:APECO1_1289 hypothetical oxidoreductase; Belongs to the LDH2/MDH2 oxidoreductase family.


ensembl_gene_id: Spro_2011
symbol: Spro_2011
gene_biotype: protein_coding
description:
  PFAM: Cupin 4 family protein; SMART: transcription factor jumonji jmjC domain protein; KEGG: yen:YE1716 hypothetical protein.


ensembl_gene_id: Spro_2012
symbol: Spro_2012
gene_biotype: protein_coding
description:
  Integral membrane sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase HAMP region domain protein; histidine kinase A domain protein; PhoQ Sensor domain protein; KEGG: yen:YE1717 sensor protein kinase.


ensembl_gene_id: Spro_2013
symbol: Spro_2013
gene_biotype: protein_coding
description:
  Two component transcriptional regulator, winged helix family; PFAM: response regulator receiver; transcriptional regulator domain protein; KEGG: ypi:YpsIP31758_1608 transcriptional regulatory protein PhoP.


ensembl_gene_id: Spro_2014
symbol: Spro_2014
gene_biotype: protein_coding
description:
  Gluconate 2-dehydrogenase (acceptor); PFAM: cytochrome c class I; KEGG: pap:PSPA7_2974 probable cytochrome c precursor.


ensembl_gene_id: Spro_2015
symbol: Spro_2015
gene_biotype: protein_coding
description:
  Gluconate 2-dehydrogenase (acceptor); PFAM: glucose-methanol-choline oxidoreductase; KEGG: bxe:Bxe_A4095 putative gluconate dehydrogenase.


ensembl_gene_id: Spro_2017
symbol: Spro_2017
gene_biotype: protein_coding
description:
  PFAM: regulatory protein GntR HTH; aminotransferase class I and II; KEGG: oan:Oant_4139 putative transcriptional regulator, GntR family.


ensembl_gene_id: Spro_2020
symbol: Spro_2020
gene_biotype: protein_coding
description:
  KEGG: yen:YE1720 adenylosuccinate lyase; TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; Adenylosuccinate lyase domain protein; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.


ensembl_gene_id: Spro_2022
symbol: mnmA
gene_biotype: protein_coding
description:
  tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln), leading to the formation of s(2)U34, the first step of tRNA-mnm(5)s(2)U34 synthesis. Sulfur is provided by IscS, via a sulfur-relay system. Binds ATP and its substrate tRNAs; Belongs to the MnmA/TRMU family.


ensembl_gene_id: Spro_2023
symbol: nudJ
gene_biotype: protein_coding
description:
  PFAM: NUDIX hydrolase; KEGG: ypi:YpsIP31758_1613 hydrolase, NUDIX family; Belongs to the Nudix hydrolase family. NudJ subfamily.


ensembl_gene_id: Spro_2024
symbol: Spro_2024
gene_biotype: protein_coding
description:
  PFAM: pseudouridine synthase; KEGG: yen:YE1724 putative pseudouridine synthase; Belongs to the pseudouridine synthase RsuA family.


ensembl_gene_id: Spro_2025
symbol: Spro_2025
gene_biotype: protein_coding
description:
  TIGRFAM: isocitrate dehydrogenase, NADP-dependent; PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: ypi:YpsIP31758_1615 isocitrate dehydrogenase, NADP-dependent.


ensembl_gene_id: Spro_2028
symbol: Spro_2028
gene_biotype: protein_coding
description:
  PFAM: integrase family protein; KEGG: ecj:JW1126 predicted integrase; Belongs to the 'phage' integrase family.


ensembl_gene_id: Spro_2034
symbol: Spro_2034
gene_biotype: protein_coding
description:
  Putative phage repressor; PFAM: peptidase S24 and S26 domain protein; KEGG: ent:Ent638_2620 putative phage repressor; Belongs to the peptidase S24 family.


ensembl_gene_id: Spro_2046
symbol: Spro_2046
gene_biotype: protein_coding
description:
  PFAM: regulatory protein AsnC/Lrp family; KEGG: ent:Ent638_0915 putative transcriptional regulator, AsnC family.


ensembl_gene_id: Spro_2051
symbol: Spro_2051
gene_biotype: protein_coding
description:
  TIGRFAM: 4-oxalocrotonate tautomerase family enzyme; PFAM: 4-oxalocrotonate tautomerase; KEGG: pen:PSEEN1931 4-oxalocrotonate tautomerase.


ensembl_gene_id: Spro_2052
symbol: Spro_2052
gene_biotype: protein_coding
description:
  PFAM: short-chain dehydrogenase/reductase SDR; KEGG: pol:Bpro_3414 short-chain dehydrogenase/reductase SDR.


ensembl_gene_id: Spro_2053
symbol: Spro_2053
gene_biotype: protein_coding
description:
  Transcriptional regulator, LacI family; PFAM: regulatory protein LacI; KEGG: kpn:KPN_01795 putative periplasmic binding protein/LacI transcriptional regulator.


ensembl_gene_id: Spro_2055
symbol: Spro_2055
gene_biotype: protein_coding
description:
  PFAM: oxidoreductase domain protein; Oxidoreductase domain; KEGG: kpn:KPN_01797 hypothetical oxidoreductase.


ensembl_gene_id: Spro_2056
symbol: Spro_2056
gene_biotype: protein_coding
description:
  PFAM: glutathione-dependent formaldehyde-activating GFA; KEGG: swi:Swit_2158 glutathione-dependent formaldehyde-activating, GFA.


ensembl_gene_id: Spro_2061
symbol: Spro_2061
gene_biotype: protein_coding
description:
  PFAM: Cold-shock protein DNA-binding; SMART: Cold shock protein; KEGG: eca:ECA2471 cold shock protein.


ensembl_gene_id: Spro_2063
symbol: Spro_2063
gene_biotype: protein_coding
description:
  PFAM: short-chain dehydrogenase/reductase SDR; KEGG: vco:VC0395_A1193 oxidoreductase, short-chain dehydrogenase/reductase family.


ensembl_gene_id: Spro_2065
symbol: Spro_2065
gene_biotype: protein_coding
description:
  PFAM: aldehyde dehydrogenase; KEGG: sfv:SFV_1314 aldehyde dehydrogenase, prefers NADP over NAD; Belongs to the aldehyde dehydrogenase family.


ensembl_gene_id: Spro_2066
symbol: Spro_2066
gene_biotype: protein_coding
description:
  Transcriptional regulator, XRE family; PFAM: helix-turn-helix domain protein; Cupin 2 conserved barrel domain protein; KEGG: kpn:KPN_01019 putative oxidoreductase/putative regulator.


ensembl_gene_id: Spro_2067
symbol: Spro_2067
gene_biotype: protein_coding
description:
  Peptidase C26; PFAM: glutamine amidotransferase class-I; peptidase C26; KEGG: kpn:KPN_01020 probable amidotransferase subunit.


ensembl_gene_id: Spro_2068
symbol: Spro_2068
gene_biotype: protein_coding
description:
  Glutamate--putrescine ligase; PFAM: glutamine synthetase catalytic region; KEGG: ecs:ECs1874 putative glutamine synthetase.


ensembl_gene_id: Spro_2069
symbol: Spro_2069
gene_biotype: protein_coding
description:
  PFAM: amino acid permease-associated region; KEGG: kpn:KPN_01022 putative amino acid/amine transport protein.


ensembl_gene_id: Spro_2070
symbol: Spro_2070
gene_biotype: protein_coding
description:
  PFAM: protein of unknown function DUF6 transmembrane; KEGG: ent:Ent638_2056 protein of unknown function DUF6, transmembrane.


ensembl_gene_id: Spro_2072
symbol: Spro_2072
gene_biotype: protein_coding
description:
  PFAM: nucleoside-specific channel-forming protein Tsx; KEGG: ecv:APECO1_1599 nucleoside-specific channel-forming protein Tsx.


ensembl_gene_id: Spro_2077
symbol: hutI
gene_biotype: protein_coding
description:
  KEGG: yen:YE2461 imidazolonepropionase; TIGRFAM: imidazolonepropionase; PFAM: amidohydrolase; Amidohydrolase 3; Belongs to the metallo-dependent hydrolases superfamily. HutI family.


ensembl_gene_id: Spro_2078
symbol: Spro_2078
gene_biotype: protein_coding
description:
  Transcriptional regulator, histidine utilization repressor, GntR family; TIGRFAM: histidine utilization repressor; PFAM: regulatory protein GntR HTH; UbiC transcription regulator-associated domain protein; KEGG: yen:YE2460 putative GntR-family transcriptional regulatory protein.


ensembl_gene_id: Spro_2079
symbol: Spro_2079
gene_biotype: protein_coding
description:
  TIGRFAM: formiminoglutamate deiminase; PFAM: amidohydrolase; KEGG: yen:YE2459 putative chlorohydrolase.


ensembl_gene_id: Spro_2081
symbol: Spro_2081
gene_biotype: protein_coding
description:
  Transcriptional regulator, LacI family; PFAM: regulatory protein LacI; periplasmic binding protein/LacI transcriptional regulator; KEGG: kpn:KPN_03263 putative bacterial regulatory protein, LacI.


ensembl_gene_id: Spro_2082
symbol: Spro_2082
gene_biotype: protein_coding
description:
  Sucrose-6-phosphate hydrolase; Enables the bacterium to metabolize sucrose as a sole carbon source; Belongs to the glycosyl hydrolase 32 family.


ensembl_gene_id: Spro_2083
symbol: Spro_2083
gene_biotype: protein_coding
description:
  TIGRFAM: oligosaccharide/H+ symporter, major facilitator superfamily (MFS); PFAM: proton/sugar symporter LacY; major facilitator superfamily MFS_1; KEGG: kpn:KPN_03262 putative galactoside permease (lactose permease, M protein) (MFS family).


ensembl_gene_id: Spro_2084
symbol: Spro_2084
gene_biotype: protein_coding
description:
  PFAM: General substrate transporter; major facilitator superfamily MFS_1; KEGG: ent:Ent638_0364 major facilitator superfamily MFS_1.


ensembl_gene_id: Spro_2085
symbol: Spro_2085
gene_biotype: protein_coding
description:
  Gluconate 2-dehydrogenase (acceptor); PFAM: cytochrome c class I; KEGG: yen:YE1086 putative cytochrome c.


ensembl_gene_id: Spro_2086
symbol: Spro_2086
gene_biotype: protein_coding
description:
  PFAM: glucose-methanol-choline oxidoreductase; FAD dependent oxidoreductase; KEGG: har:HEAR2557 glucose dehydrogenase.


ensembl_gene_id: Spro_2089
symbol: Spro_2089
gene_biotype: protein_coding
description:
  PFAM: 6-phosphogluconate dehydrogenase NAD-binding; Phosphogluconate dehydrogenase, NAD-binding, putative-like; KEGG: kpn:KPN_04046 putative dehydrogenase.


ensembl_gene_id: Spro_2091
symbol: Spro_2091
gene_biotype: protein_coding
description:
  TIGRFAM: 4-carboxy-4-hydroxy-2-oxoadipate aldolase/oxaloacetate decarboxylase; PFAM: Dimethylmenaquinone methyltransferase; KEGG: ppf:Pput_3204 4-carboxy-4-hydroxy-2-oxoadipate aldolase/oxaloacetate decarboxylase.


ensembl_gene_id: Spro_2093
symbol: Spro_2093
gene_biotype: protein_coding
description:
  Transcriptional regulator, LysR family; PFAM: regulatory protein LysR; LysR substrate-binding; KEGG: ppu:PP_2516 transcriptional regulator, LysR family.


ensembl_gene_id: Spro_2094
symbol: aroQ
gene_biotype: protein_coding
description:
  3-dehydroquinate dehydratase, type II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family.


ensembl_gene_id: Spro_2096
symbol: Spro_2096
gene_biotype: protein_coding
description:
  Protocatechuate 4,5-dioxygenase; PFAM: Extradiol ring-cleavage dioxygenase class III protein subunit B; Extradiol ring-cleavage dioxygenase LigAB LigA subunit; KEGG: kpn:KPN_04051 2,3-dihydroxyphenylpropionate 1,2-dioxygenase.


ensembl_gene_id: Spro_2097
symbol: Spro_2097
gene_biotype: protein_coding
description:
  PFAM: General substrate transporter; major facilitator superfamily MFS_1; KEGG: kpn:KPN_04052 putative general substrate transporter.


ensembl_gene_id: Spro_2098
symbol: pckA
gene_biotype: protein_coding
description:
  Phosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.


ensembl_gene_id: Spro_2108
symbol: Spro_2108
gene_biotype: protein_coding
description:
  PFAM: fimbrial biogenesis outer membrane usher protein; KEGG: yen:YE1857 probable outer membrane usher protein.


ensembl_gene_id: Spro_2113
symbol: rsmF
gene_biotype: protein_coding
description:
  Putative RNA methylase, NOL1/NOP2/sun family; Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA.


ensembl_gene_id: Spro_2116
symbol: Spro_2116
gene_biotype: protein_coding
description:
  TIGRFAM: integral membrane protein, PqiA family; PFAM: Paraquat-inducible protein A; KEGG: yen:YE1865 hypothetical protein.


ensembl_gene_id: Spro_2118
symbol: proQ
gene_biotype: protein_coding
description:
  ProQ activator of osmoprotectant transporter ProP; RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities. May regulate ProP activity through an RNA-based, post-transcriptional mechanism. Belongs to the ProQ family.


ensembl_gene_id: Spro_2119
symbol: Spro_2119
gene_biotype: protein_coding
description:
  KEGG: yen:YE1868 tail-specific protease precursor; TIGRFAM: carboxyl-terminal protease; PFAM: PDZ/DHR/GLGF domain protein; peptidase S41; Belongs to the peptidase S41A family.


ensembl_gene_id: Spro_2120
symbol: htpX
gene_biotype: protein_coding
description:
  HtpX domain protein; PFAM: peptidase M48 Ste24p; HtpX domain protein; KEGG: yen:YE1869 putative heat shock protein; Belongs to the peptidase M48B family.


ensembl_gene_id: Spro_2122
symbol: Spro_2122
gene_biotype: protein_coding
description:
  PFAM: regulatory protein IclR; Transcriptional regulator IclR; KEGG: yen:YE1877 IclR-family transcriptional regulatory protein.


ensembl_gene_id: Spro_2123
symbol: Spro_2123
gene_biotype: protein_coding
description:
  PFAM: sodium:dicarboxylate symporter; KEGG: yen:YE1879 putative transport protein; Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.


ensembl_gene_id: Spro_2125
symbol: Spro_2125
gene_biotype: protein_coding
description:
  TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: ypi:YpsIP31758_1697 HAD hydrolase, IA family.


ensembl_gene_id: Spro_2128
symbol: Spro_2128
gene_biotype: protein_coding
description:
  Fructosamine kinase; PFAM: aminoglycoside phosphotransferase; fructosamine kinase; KEGG: yen:YE1896 hypothetical protein.


ensembl_gene_id: Spro_2131
symbol: Spro_2131
gene_biotype: protein_coding
description:
  ABC-3 protein; PFAM: transport system permease protein; ABC-3 protein; KEGG: ypi:YpsIP31758_1703 chelated iron ABC transporter, permease protein YfeC.


ensembl_gene_id: Spro_2132
symbol: Spro_2132
gene_biotype: protein_coding
description:
  ABC transporter-related protein; PFAM: ABC transporter related; SMART: AAA ATPase; KEGG: yen:YE1899 ATP-binding transport protein.


ensembl_gene_id: Spro_2133
symbol: Spro_2133
gene_biotype: protein_coding
description:
  PFAM: periplasmic solute binding protein; KEGG: eca:ECA2392 periplasmic chelated iron-binding protein; Belongs to the bacterial solute-binding protein 9 family.


ensembl_gene_id: Spro_2135
symbol: Spro_2135
gene_biotype: protein_coding
description:
  PFAM: Lytic transglycosylase catalytic; KEGG: yps:YPTB2346 putative membrane-bound lytic murein transglycosylase.


ensembl_gene_id: Spro_2137
symbol: Spro_2137
gene_biotype: protein_coding
description:
  Gluconate 2-dehydrogenase (acceptor); PFAM: glucose-methanol-choline oxidoreductase; KEGG: kpn:KPN_02083 monooxygenase, FAD-binding; glucose-methanol-choline oxidoreductase.


ensembl_gene_id: Spro_2138
symbol: Spro_2138
gene_biotype: protein_coding
description:
  Gluconate 2-dehydrogenase (acceptor); PFAM: cytochrome c class I; KEGG: kpn:KPN_02082 gluconate dehydrogenase cytochrome c subunit, putative.


ensembl_gene_id: Spro_2141
symbol: Spro_2141
gene_biotype: protein_coding
description:
  PFAM: multiple antibiotic resistance (MarC)-related protein; KEGG: yps:YPTB2345 multiple antibiotic resistance protein.


ensembl_gene_id: Spro_2144
symbol: thrS
gene_biotype: protein_coding
description:
  threonyl-tRNA synthetase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).


ensembl_gene_id: Spro_2145
symbol: Spro_2145
gene_biotype: protein_coding
description:
  PFAM: initiation factor 3; KEGG: ypi:YpsIP31758_1713 translation initiation factor IF-3; Belongs to the IF-3 family.


ensembl_gene_id: Spro_2146
symbol: rpmI
gene_biotype: protein_coding
description:
  PFAM: ribosomal protein L35; KEGG: yen:YE1914 50S ribosomal protein L35; Belongs to the bacterial ribosomal protein bL35 family.


ensembl_gene_id: Spro_2147
symbol: rplT
gene_biotype: protein_coding
description:
  Ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.


ensembl_gene_id: Spro_2148
symbol: pheS
gene_biotype: protein_coding
description:
  TIGRFAM: phenylalanyl-tRNA synthetase, alpha subunit; PFAM: phenylalanyl-tRNA synthetase class IIc; aminoacyl tRNA synthetase class II domain protein; KEGG: ypi:YpsIP31758_1716 phenylalanyl-tRNA synthetase, alpha subunit; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.


ensembl_gene_id: Spro_2149
symbol: pheT
gene_biotype: protein_coding
description:
  KEGG: ypp:YPDSF_0722 phenylalanyl-tRNA synthetase beta chain; TIGRFAM: phenylalanyl-tRNA synthetase, beta subunit; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.


ensembl_gene_id: Spro_2150
symbol: ihfA
gene_biotype: protein_coding
description:
  Integration host factor, alpha subunit; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family.


ensembl_gene_id: Spro_2151
symbol: btuC
gene_biotype: protein_coding
description:
  Transport system permease protein; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane.


ensembl_gene_id: Spro_2152
symbol: btuE
gene_biotype: protein_coding
description:
  Glutathione peroxidase; Non-specific peroxidase that can use thioredoxin or glutathione as a reducing agent.


ensembl_gene_id: Spro_2153
symbol: btuD
gene_biotype: protein_coding
description:
  ABC transporter-related protein; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system.


ensembl_gene_id: Spro_2154
symbol: arnB
gene_biotype: protein_coding
description:
  DegT/DnrJ/EryC1/StrS aminotransferase; Catalyzes the conversion of UDP-4-keto-arabinose (UDP-Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; Belongs to the DegT/DnrJ/EryC1 family. ArnB subfamily.


ensembl_gene_id: Spro_2155
symbol: arnC
gene_biotype: protein_coding
description:
  Glycosyl transferase family 2; Catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.


ensembl_gene_id: Spro_2156
symbol: arnA
gene_biotype: protein_coding
description:
  NAD-dependent epimerase/dehydratase; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; In the C-terminal section; belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.


ensembl_gene_id: Spro_2157
symbol: arnD
gene_biotype: protein_coding
description:
  Polysaccharide deacetylase; Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; Belongs to the polysaccharide deacetylase family. ArnD deformylase subfamily.


ensembl_gene_id: Spro_2158
symbol: arnT
gene_biotype: protein_coding
description:
  Glycosyl transferase family 39; Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides. Belongs to the glycosyltransferase 83 family.


ensembl_gene_id: Spro_2159
symbol: arnE
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane; Belongs to the ArnE family.


ensembl_gene_id: Spro_2160
symbol: arnF
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane; Belongs to the ArnF family.


ensembl_gene_id: Spro_2162
symbol: lplA
gene_biotype: protein_coding
description:
  Lipoyltransferase and lipoate-protein ligase; Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes.


ensembl_gene_id: Spro_2164
symbol: selO
gene_biotype: protein_coding
description:
  Protein of unknown function UPF0061; Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation). Belongs to the SELO family.


ensembl_gene_id: Spro_2165
symbol: hmuV
gene_biotype: protein_coding
description:
  ABC transporter-related protein; Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system.


ensembl_gene_id: Spro_2166
symbol: Spro_2166
gene_biotype: protein_coding
description:
  PFAM: transport system permease protein; KEGG: yen:YE0328 hemin transport system permease protein HmuU; Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.


ensembl_gene_id: Spro_2167
symbol: Spro_2167
gene_biotype: protein_coding
description:
  PFAM: periplasmic binding protein; KEGG: ypi:YpsIP31758_3803 hemin ABC transporter, periplasmic hemin-binding protein.


ensembl_gene_id: Spro_2169
symbol: Spro_2169
gene_biotype: protein_coding
description:
  TIGRFAM: TonB-dependent hemoglobin/transferrin/lactoferrin family receptor; TonB-dependent heme/hemoglobin receptor family protein; PFAM: TonB-dependent receptor; TonB-dependent receptor plug; KEGG: yen:YE0331 hemin receptor precursor.


ensembl_gene_id: Spro_2171
symbol: Spro_2171
gene_biotype: protein_coding
description:
  PFAM: glutathione peroxidase; KEGG: pae:PA2826 probable glutathione peroxidase; Belongs to the glutathione peroxidase family.


ensembl_gene_id: Spro_2173
symbol: Spro_2173
gene_biotype: protein_coding
description:
  Protein of unknown function DUF299; Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation.


ensembl_gene_id: Spro_2174
symbol: Spro_2174
gene_biotype: protein_coding
description:
  Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family.


ensembl_gene_id: Spro_2177
symbol: menI
gene_biotype: protein_coding
description:
  Thioesterase superfamily protein; Catalyzes the hydrolysis of 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA) to 1,4-dihydroxy-2-naphthoate (DHNA).


ensembl_gene_id: Spro_2179
symbol: Spro_2179
gene_biotype: protein_coding
description:
  FeS assembly scaffold SufA; TIGRFAM: iron-sulfur cluster assembly accessory protein; FeS assembly scaffold SufA; PFAM: HesB/YadR/YfhF-family protein; KEGG: ypi:YpsIP31758_1741 FeS assembly scaffold SufA; Belongs to the HesB/IscA family.


ensembl_gene_id: Spro_2181
symbol: Spro_2181
gene_biotype: protein_coding
description:
  FeS assembly ATPase SufC; KEGG: yps:YPTB2312 putative ATP-dependent transporter; TIGRFAM: FeS assembly ATPase SufC; PFAM: ABC transporter related; SMART: AAA ATPase.


ensembl_gene_id: Spro_2182
symbol: Spro_2182
gene_biotype: protein_coding
description:
  TIGRFAM: FeS assembly protein SufD; PFAM: SufBD protein; KEGG: ypi:YpsIP31758_1744 FeS assembly protein SufD.


ensembl_gene_id: Spro_2183
symbol: sufS
gene_biotype: protein_coding
description:
  Cysteine desulfurase, SufS subfamily; Cysteine desulfurases mobilize the sulfur from L-cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation. Acts as a potent selenocysteine lyase in vitro, that mobilizes selenium from L- selenocysteine. Selenocysteine lyase activity is however unsure in vivo.


ensembl_gene_id: Spro_2184
symbol: sufE
gene_biotype: protein_coding
description:
  Fe-S metabolism associated SufE; Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L- alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process; Belongs to the SufE family.


ensembl_gene_id: Spro_2187
symbol: Spro_2187
gene_biotype: protein_coding
description:
  KEGG: yen:YE2164 pyruvate kinase I; TIGRFAM: pyruvate kinase; PFAM: Pyruvate kinase barrel; Pyruvate kinase alpha/beta; Belongs to the pyruvate kinase family.


ensembl_gene_id: Spro_2189
symbol: mdtK
gene_biotype: protein_coding
description:
  MATE efflux family protein; Multidrug efflux pump that functions probably as a Na(+)/drug antiporter; Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MdtK subfamily.


ensembl_gene_id: Spro_2190
symbol: Spro_2190
gene_biotype: protein_coding
description:
  TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein; KEGG: yen:YE2162 riboflavin synthase alpha chain.


ensembl_gene_id: Spro_2192
symbol: Spro_2192
gene_biotype: protein_coding
description:
  PFAM: Cyclopropane-fatty-acyl-phospholipid synthase; Methyltransferase type 11; Methyltransferase type 12; KEGG: yen:YE2161 cyclopropane-fatty-acyl-phospholipid synthase.


ensembl_gene_id: Spro_2193
symbol: Spro_2193
gene_biotype: protein_coding
description:
  TIGRFAM: drug resistance transporter, Bcr/CflA subfamily; PFAM: major facilitator superfamily MFS_1; KEGG: yen:YE2160 putative drug resistance protein.


ensembl_gene_id: Spro_2194
symbol: Spro_2194
gene_biotype: protein_coding
description:
  Transcriptional regulator, LysR family; PFAM: regulatory protein LysR; LysR substrate-binding; KEGG: ypp:YPDSF_0759 LysR-family transcriptional regulatory protein.


ensembl_gene_id: Spro_2195
symbol: purR
gene_biotype: protein_coding
description:
  Transcriptional regulator, LacI family; Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression.


ensembl_gene_id: Spro_2198
symbol: Spro_2198
gene_biotype: protein_coding
description:
  TIGRFAM: glutaredoxin-like protein; PFAM: glutaredoxin; KEGG: ypi:YpsIP31758_1758 monothiol glutaredoxin GrxD; Belongs to the glutaredoxin family. Monothiol subfamily.


ensembl_gene_id: Spro_2199
symbol: rnt
gene_biotype: protein_coding
description:
  Ribonuclease T; Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis.


ensembl_gene_id: Spro_2200
symbol: Spro_2200
gene_biotype: protein_coding
description:
  KEGG: yen:YE2153 lactoylglutathione lyase; TIGRFAM: lactoylglutathione lyase; PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase.


ensembl_gene_id: Spro_2201
symbol: idi
gene_biotype: protein_coding
description:
  Isopentenyl-diphosphate delta-isomerase, type 1; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).


ensembl_gene_id: Spro_2202
symbol: Spro_2202
gene_biotype: protein_coding
description:
  PFAM: NADH:flavin oxidoreductase/NADH oxidase; KEGG: yen:YE2152 NADH:flavin oxidoreductase / NADH oxidase family protein.


ensembl_gene_id: Spro_2205
symbol: Spro_2205
gene_biotype: protein_coding
description:
  PFAM: NAD-dependent epimerase/dehydratase; 3-beta hydroxysteroid dehydrogenase/isomerase; KEGG: pmy:Pmen_0809 3-beta hydroxysteroid dehydrogenase/isomerase.


ensembl_gene_id: Spro_2209
symbol: Spro_2209
gene_biotype: protein_coding
description:
  Triacylglycerol lipase; PFAM: Hemolysin-type calcium-binding region; lipase class 3; KEGG: plu:plu2313 hypothetical protein.


ensembl_gene_id: Spro_2210
symbol: Spro_2210
gene_biotype: protein_coding
description:
  Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family.


ensembl_gene_id: Spro_2212
symbol: Spro_2212
gene_biotype: protein_coding
description:
  PFAM: secretion protein HlyD family protein; KEGG: yen:YE2146 putative HlyD-family protein; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.


ensembl_gene_id: Spro_2214
symbol: slyA
gene_biotype: protein_coding
description:
  Transcriptional regulator, MarR family; Transcription regulator that can specifically activate or repress expression of target genes; Belongs to the SlyA family.


ensembl_gene_id: Spro_2216
symbol: anmK
gene_biotype: protein_coding
description:
  Protein of unknown function UPF0075; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family.


ensembl_gene_id: Spro_2218
symbol: pdxH
gene_biotype: protein_coding
description:
  Pyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).


ensembl_gene_id: Spro_2219
symbol: tyrS
gene_biotype: protein_coding
description:
  tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.


ensembl_gene_id: Spro_2220
symbol: pdxY
gene_biotype: protein_coding
description:
  Pyridoxal kinase; Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP.


ensembl_gene_id: Spro_2221
symbol: Spro_2221
gene_biotype: protein_coding
description:
  PFAM: Glutathione S-transferase domain; KEGG: yen:YE2137 glutathione S-transferase; Belongs to the GST superfamily.


ensembl_gene_id: Spro_2222
symbol: dapA
gene_biotype: protein_coding
description:
  Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).


ensembl_gene_id: Spro_2224
symbol: Spro_2224
gene_biotype: protein_coding
description:
  PFAM: metal-dependent phosphohydrolase HD sub domain; SMART: metal-dependent phosphohydrolase HD region; KEGG: sme:SMc02632 hypothetical protein.


ensembl_gene_id: Spro_2227
symbol: Spro_2227
gene_biotype: protein_coding
description:
  PFAM: aminoglycoside/hydroxyurea antibiotic resistance kinase; KEGG: pau:PA14_40450 streptomycin 3''-phosphotransferase.


ensembl_gene_id: Spro_2228
symbol: Spro_2228
gene_biotype: protein_coding
description:
  PFAM: Cupin 2 conserved barrel domain protein; KEGG: psp:PSPPH_1841 auxin-binding protein, putative.


ensembl_gene_id: Spro_2230
symbol: Spro_2230
gene_biotype: protein_coding
description:
  TIGRFAM: benzoate transporter; PFAM: Benzoate membrane transport protein; Xanthine/uracil/vitamin C permease; KEGG: plu:plu0511 unnamed protein product; highly similar to benzoate membrane transport protein.


ensembl_gene_id: Spro_2231
symbol: Spro_2231
gene_biotype: protein_coding
description:
  Transcriptional regulator, XRE family; PFAM: helix-turn-helix domain protein; Cupin 2 conserved barrel domain protein; KEGG: eca:ECA4472 putative DNA-binding protein.


ensembl_gene_id: Spro_2232
symbol: Spro_2232
gene_biotype: protein_coding
description:
  PFAM: peptidase S9 prolyl oligopeptidase active site domain protein; peptidase S9A prolyl oligopeptidase domain protein beta-propeller; KEGG: xcv:XCV0685 putative prolyl oligopeptidase precursor.


ensembl_gene_id: Spro_2233
symbol: dtpA
gene_biotype: protein_coding
description:
  Amino acid/peptide transporter; Proton-dependent permease that transports di- and tripeptides; Belongs to the PTR2/POT transporter (TC 2.A.17) family. DtpA subfamily.


ensembl_gene_id: Spro_2234
symbol: nth
gene_biotype: protein_coding
description:
  Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.


ensembl_gene_id: Spro_2235
symbol: rnfE
gene_biotype: protein_coding
description:
  Electron transport complex, RnfABCDGE type, E subunit; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.


ensembl_gene_id: Spro_2236
symbol: rnfG
gene_biotype: protein_coding
description:
  Electron transport complex, RnfABCDGE type, G subunit; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the RnfG family.


ensembl_gene_id: Spro_2237
symbol: rnfD
gene_biotype: protein_coding
description:
  Electron transport complex, RnfABCDGE type, D subunit; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the NqrB/RnfD family.


ensembl_gene_id: Spro_2238
symbol: Spro_2238
gene_biotype: protein_coding
description:
  Transcriptional regulator, AraC family; PFAM: helix-turn-helix- domain containing protein AraC type; KEGG: yen:YE1991 putative AraC-family transcriptional regulatory protein.


ensembl_gene_id: Spro_2239
symbol: rnfC
gene_biotype: protein_coding
description:
  Electron transport complex, RnfABCDGE type, C subunit; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.


ensembl_gene_id: Spro_2240
symbol: rnfB
gene_biotype: protein_coding
description:
  Electron transport complex, RnfABCDGE type, B subunit; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.


ensembl_gene_id: Spro_2241
symbol: rnfA
gene_biotype: protein_coding
description:
  Electron transport complex, RnfABCDGE type, A subunit; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.


ensembl_gene_id: Spro_2245
symbol: Spro_2245
gene_biotype: protein_coding
description:
  Monosaccharide-transporting ATPase; PFAM: periplasmic binding protein/LacI transcriptional regulator; KEGG: yen:YE2003 L-arabinose-binding periplasmic protein precursor.


ensembl_gene_id: Spro_2246
symbol: araG
gene_biotype: protein_coding
description:
  ABC transporter-related protein; Part of the ABC transporter complex AraFGH involved in arabinose import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Arabinose importer (TC 3.A.1.2.2) family.


ensembl_gene_id: Spro_2247
symbol: Spro_2247
gene_biotype: protein_coding
description:
  Monosaccharide-transporting ATPase; PFAM: inner-membrane translocator; KEGG: ent:Ent638_2474 inner-membrane translocator; Belongs to the binding-protein-dependent transport system permease family.


ensembl_gene_id: Spro_2248
symbol: Spro_2248
gene_biotype: protein_coding
description:
  Transcriptional regulator, AraC family; PFAM: helix-turn-helix- domain containing protein AraC type; AraC protein arabinose-binding/dimerisation; KEGG: yen:YE2006 arabinose operon regulatory protein.


ensembl_gene_id: Spro_2249
symbol: Spro_2249
gene_biotype: protein_coding
description:
  Oxidoreductase domain protein; PFAM: Semialdehyde dehydrogenase NAD - binding; oxidoreductase domain protein; Oxidoreductase domain; KEGG: yen:YE2007 putative oxidoreductase.


ensembl_gene_id: Spro_2251
symbol: add
gene_biotype: protein_coding
description:
  KEGG: yen:YE2009 adenosine deaminase; TIGRFAM: adenosine deaminase; PFAM: adenosine/AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.


ensembl_gene_id: Spro_2253
symbol: Spro_2253
gene_biotype: protein_coding
description:
  Putative PTS IIA-like nitrogen-regulatory protein PtsN; PFAM: phosphoenolpyruvate-dependent sugar phosphotransferase system EIIA 2; KEGG: kpn:KPN_04197 putative PTS family enzyme IIA component.


ensembl_gene_id: Spro_2255
symbol: Spro_2255
gene_biotype: protein_coding
description:
  KEGG: kpn:KPN_04196 putative ketose-bisphosphate aldolase, class-II; TIGRFAM: ketose-bisphosphate aldolase; PFAM: ketose-bisphosphate aldolase class-II.


ensembl_gene_id: Spro_2256
symbol: Spro_2256
gene_biotype: protein_coding
description:
  PFAM: putative sugar-specific permease SgaT/UlaA; KEGG: kpn:KPN_04195 putative membrane protein, transport.


ensembl_gene_id: Spro_2257
symbol: Spro_2257
gene_biotype: protein_coding
description:
  PFAM: phosphotransferase system lactose/cellobiose-specific IIB subunit; KEGG: kpn:KPN_04194 putative PTS family enzyme II component.


ensembl_gene_id: Spro_2258
symbol: Spro_2258
gene_biotype: protein_coding
description:
  Phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family.


ensembl_gene_id: Spro_2259
symbol: Spro_2259
gene_biotype: protein_coding
description:
  Transcriptional regulator, DeoR family; PFAM: regulatory protein DeoR; Helix-turn-helix type 11 domain protein; KEGG: bch:Bcen2424_0941 transcriptional regulator, DeoR family.


ensembl_gene_id: Spro_2263
symbol: Spro_2263
gene_biotype: protein_coding
description:
  TIGRFAM: PTS system, maltose and glucose-specific subfamily, IIC subunit; PTS system, maltose and glucose-specific IIBC subunit; PTS system, glucose-like IIB subunint; PFAM: phosphotransferase system PTS EIIB protein; phosphotransferase system EIIC; KEGG: yen:YE2011 PTS system, maltose and glucose-specific IIAbc component.


ensembl_gene_id: Spro_2264
symbol: Spro_2264
gene_biotype: protein_coding
description:
  PFAM: integrase family protein; KEGG: yen:YE2364 putative phage integrase; Belongs to the 'phage' integrase family.


ensembl_gene_id: Spro_2265
symbol: Spro_2265
gene_biotype: protein_coding
description:
  PFAM: protein of unknown function DUF1233 excisionase putative; KEGG: ypm:YP_1930 putative phage excisionase.


ensembl_gene_id: Spro_2271
symbol: Spro_2271
gene_biotype: protein_coding
description:
  Transcriptional regulator, LacI family; PFAM: regulatory protein LacI; periplasmic binding protein/LacI transcriptional regulator; KEGG: yen:YE2012 maltose regulon regulatory protein.


ensembl_gene_id: Spro_2272
symbol: Spro_2272
gene_biotype: protein_coding
description:
  Transcriptional regulator, LysR family; PFAM: regulatory protein LysR; LysR substrate-binding; KEGG: bam:Bamb_4361 transcriptional regulator, LysR family.


ensembl_gene_id: Spro_2274
symbol: Spro_2274
gene_biotype: protein_coding
description:
  Transcriptional regulator, LysR family; PFAM: regulatory protein LysR; LysR substrate-binding; KEGG: vpa:VP1676 putative transcriptional regulator.


ensembl_gene_id: Spro_2277
symbol: Spro_2277
gene_biotype: protein_coding
description:
  TIGRFAM: mannose-6-phosphate isomerase, class I; PFAM: mannose-6-phosphate isomerase type I; KEGG: yen:YE2015 mannose-6-phosphate isomerase.


ensembl_gene_id: Spro_2279
symbol: fumC
gene_biotype: protein_coding
description:
  Fumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.


ensembl_gene_id: Spro_2280
symbol: tus
gene_biotype: protein_coding
description:
  DNA replication terminus site-binding protein; Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence; Belongs to the Tus family.


ensembl_gene_id: Spro_2281
symbol: Spro_2281
gene_biotype: protein_coding
description:
  PFAM: General substrate transporter; major facilitator superfamily MFS_1; KEGG: yen:YE2021 hypothetical protein.


ensembl_gene_id: Spro_2282
symbol: Spro_2282
gene_biotype: protein_coding
description:
  Transcriptional regulator, LysR family; PFAM: regulatory protein LysR; LysR substrate-binding; KEGG: yen:YE2022 probable LysR-family transcriptional regulator.


ensembl_gene_id: Spro_2285
symbol: clcB
gene_biotype: protein_coding
description:
  Chloride channel core; Probably acts as an electrical shunt for an outwardly- directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response; Belongs to the chloride channel (TC 2.A.49) family. ClcB subfamily.


ensembl_gene_id: Spro_2286
symbol: Spro_2286
gene_biotype: protein_coding
description:
  TIGRFAM: drug resistance transporter, EmrB/QacA subfamily; PFAM: major facilitator superfamily MFS_1; KEGG: eca:ECA2256 putative transporter.


ensembl_gene_id: Spro_2288
symbol: Spro_2288
gene_biotype: protein_coding
description:
  PFAM: protein of unknown function DUF1283; KEGG: yen:YE2026 hypothetical protein; Belongs to the UPF0482 family.


ensembl_gene_id: Spro_2290
symbol: Spro_2290
gene_biotype: protein_coding
description:
  PFAM: NAD-dependent epimerase/dehydratase; short-chain dehydrogenase/reductase SDR; KR domain protein; KEGG: ypi:YpsIP31758_1864 oxidoreductase, short chain dehydrogenase/reductase family protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.


ensembl_gene_id: Spro_2293
symbol: Spro_2293
gene_biotype: protein_coding
description:
  ABC transporter-related protein; PFAM: ABC transporter related; Transport-associated OB domain protein; SMART: AAA ATPase; KEGG: vei:Veis_1240 ABC transporter related; Belongs to the ABC transporter superfamily.


ensembl_gene_id: Spro_2294
symbol: Spro_2294
gene_biotype: protein_coding
description:
  PFAM: PfkB domain protein; KEGG: ret:RHE_CH03378 probable sugar kinase protein; Belongs to the carbohydrate kinase PfkB family.


ensembl_gene_id: Spro_2295
symbol: Spro_2295
gene_biotype: protein_coding
description:
  PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: sme:SMb21219 putative sugar uptake ABC transporter permease protein.


ensembl_gene_id: Spro_2296
symbol: Spro_2296
gene_biotype: protein_coding
description:
  PFAM: binding-protein-dependent transport systems inner membrane component; KEGG: smd:Smed_4556 binding-protein-dependent transport systems inner membrane component.


ensembl_gene_id: Spro_2297
symbol: Spro_2297
gene_biotype: protein_coding
description:
  PFAM: extracellular solute-binding protein family 1; KEGG: ret:RHE_CH03374 probable sugar ABC transporter, substrate-binding protein.


ensembl_gene_id: Spro_2299
symbol: Spro_2299
gene_biotype: protein_coding
description:
  Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.


ensembl_gene_id: Spro_2300
symbol: Spro_2300
gene_biotype: protein_coding
description:
  TIGRFAM: Xanthine dehydrogenase small subunit; PFAM: ferredoxin; molybdopterin dehydrogenase FAD-binding; [2Fe-2S]-binding domain protein; CO dehydrogenase flavoprotein domain protein; KEGG: pst:PSPTO_3660 xanthine dehydrogenase, N-terminal subunit.


ensembl_gene_id: Spro_2301
symbol: Spro_2301
gene_biotype: protein_coding
description:
  KEGG: pau:PA14_44740 xanthine dehydrogenase; TIGRFAM: Xanthine dehydrogenase molybdopterin binding subunit; PFAM: aldehyde oxidase and xanthine dehydrogenase a/b hammerhead; aldehyde oxidase and xanthine dehydrogenase molybdopterin binding.


ensembl_gene_id: Spro_2302
symbol: Spro_2302
gene_biotype: protein_coding
description:
  TIGRFAM: Xanthine dehydrogenase accessory protein XdhC; PFAM: protein of unknown function DUF182; KEGG: pau:PA14_44760 putative xanthine dehydrogenase accessory factor X.


