# geneInfo

ensembl_gene_id: YJL223C
symbol: PAU1
gene_biotype: protein_coding
description:
  Member of the seripauperin multigene family; encoded mainly in subtelomeric regions; SWAT-GFP and mCherry fusion proteins localize to the vacuole; active during alcoholic fermentation; regulated by anaerobiosis, negatively regulated by oxygen; repressed by heme; identical to Pau14p.


ensembl_gene_id: YJL225W-A
symbol: YJL225W-A
gene_biotype: protein_coding
description:
  Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the uncharacterized gene YJL225C.


ensembl_gene_id: YJR001W
symbol: AVT1
gene_biotype: protein_coding
description:
  Vacuolar transporter; imports large neutral amino acids into the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters.


ensembl_gene_id: YJR002W
symbol: MPP10
gene_biotype: protein_coding
description:
  U3 small nucleolar RNA-associated protein MPP10; Component of the SSU processome and 90S preribosome; required for pre-18S rRNA processing, interacts with and controls the stability of Imp3p and Imp4p, essential for viability; similar to human Mpp10p.


ensembl_gene_id: YJR003C
symbol: MRX12
gene_biotype: protein_coding
description:
  MIOREX complex component 12; Protein that associates with mitochondrial ribosome; detected in highly purified mitochondria in high-throughput studies; predicted to be involved in ribosome biogenesis.


ensembl_gene_id: YJR004C
symbol: SAG1
gene_biotype: protein_coding
description:
  Alpha-agglutinin of alpha-cells; binds to Aga1p during agglutination, N-terminal half is homologous to the immunoglobulin superfamily and contains binding site for a-agglutinin, C-terminal half is highly glycosylated and contains GPI anchor; To C.albicans ALS1.


ensembl_gene_id: YJR005C-A
symbol: LSO1
gene_biotype: protein_coding
description:
  Protein with a potential role in response to iron deprivation; transcription increases during iron deprivation and during treatment with 2-(6-benzyl-2-pyridyl)quinazoline (BPQ) and copper; regulated by Aft1p and, to a lesser extent, by Aft2p; originally identified as a syntenic homolog of an Ashbya gossypii gene; localizes to nucleus and cytoplasm, and nuclear localization is enhanced under iron-replete conditions.


ensembl_gene_id: YJR005W
symbol: APL1
gene_biotype: protein_coding
description:
  Beta-adaptin; large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport; similar to mammalian beta-chain of the clathrin associated protein complex.


ensembl_gene_id: YJR006W
symbol: POL31
gene_biotype: protein_coding
description:
  Subunit of DNA polymerase delta (polymerase III); essential for cell viability; involved in DNA replication and DNA repair; forms a complex with Rev3p, Rev7p and Pol32p; relocalizes to the cytosol in response to hypoxia.


ensembl_gene_id: YJR007W
symbol: SUI2
gene_biotype: protein_coding
description:
  Alpha subunit of the translation initiation factor eIF2; eIF2 is involved in identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YJR008W
symbol: MHO1
gene_biotype: protein_coding
description:
  MEMO1 family protein MHO1; Protein of unknown function; inhibits haploid invasive growth when overexpressed; synthetically lethal with phospholipase C (PLC1); expression induced by mild heat-stress on a non-fermentable carbon source, upon entry into stationary phase and upon nitrogen deprivation; repressed by inosine and choline in an Opi1p-dependent manner; highly conserved from bacteria to human; Memo, the human homolog, is an ErbB2 interacting protein with an essential function in cell motility.


ensembl_gene_id: YJR009C
symbol: TDH2
gene_biotype: protein_coding
description:
  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 2; involved in glycolysis and gluconeogenesis; tetramer that catalyzes reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in cytoplasm and cell wall; protein abundance increases in response to DNA replication stress; GAPDH-derived antimicrobial peptides are active against a wide variety of wine-related yeasts and bateria; TDH2 has a paralog, TDH3, that arose from the whole genome duplication.


ensembl_gene_id: YJR010C-A
symbol: SPC1
gene_biotype: protein_coding
description:
  Subunit of the signal peptidase complex (SPC); SPC cleaves the signal sequence from proteins targeted to the endoplasmic reticulum (ER); homolog of the SPC12 subunit of mammalian signal peptidase complex; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YJR010W
symbol: MET3
gene_biotype: protein_coding
description:
  Sulfate adenylyltransferase; ATP sulfurylase; catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism; human homolog PAPSS2 complements yeast null mutant.


ensembl_gene_id: YJR011C
symbol: YJR011C
gene_biotype: protein_coding
description:
  Uncharacterized protein YJR011C; Putative protein of unknown function; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS.


ensembl_gene_id: YJR012C
symbol: YJR012C
gene_biotype: protein_coding
description:
  Uncharacterized protein YJR012C; Essential protein of unknown function; proposed involvement in transport based on mass spectrometry analysis of copurifying proteins; partially overlaps neighboring ORF, GPI14/YJR013W.


ensembl_gene_id: YJR013W
symbol: GPI14
gene_biotype: protein_coding
description:
  GPI mannosyltransferase 1; Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I; involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M.


ensembl_gene_id: YJR014W
symbol: TMA22
gene_biotype: protein_coding
description:
  Translation machinery-associated protein 22; Protein of unknown function; associates with ribosomes and has a putative RNA binding domain; interacts with Tma20p; similar to human GRAP and human DRP1, which interacts with human Tma20p homolog MCT-1; protein abundance increases in response to DNA replication stress; Belongs to the DENR family.


ensembl_gene_id: YJR015W
symbol: YJR015W
gene_biotype: protein_coding
description:
  Putative protein of unknown function; localizes to endoplasmic reticulum and cytoplasm; predicted to encode a membrane transporter based on phylogenetic analysis; not an essential gene; YJR015W has a paralog, SNG1, that arose from the whole genome duplication; To yeast SNG1.


ensembl_gene_id: YJR016C
symbol: ILV3
gene_biotype: protein_coding
description:
  Dihydroxy-acid dehydratase, mitochondrial; Dihydroxyacid dehydratase; catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids.


ensembl_gene_id: YJR017C
symbol: ESS1
gene_biotype: protein_coding
description:
  Peptidyl-prolyl cis-trans isomerase ESS1; Peptidylprolyl-cis/trans-isomerase (PPIase); specific for phosphorylated S/T residues N-terminal to proline; regulates phosphorylation of RNAPII large subunit (Rpo21p) C-terminal domain (CTD) at Ser7; associates with phospho-Ser5 form of RNAPII in vivo; present along entire coding length of genes; represses initiation of CUTs; required for efficient termination of mRNA transcription, trimethylation of histone H3; human ortholog PIN1 can complement yeast null and ts mutants; Belongs to the PpiC/parvulin rotamase family.


ensembl_gene_id: YJR018W
symbol: YJR018W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YJR018W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YJR019C
symbol: TES1
gene_biotype: protein_coding
description:
  Peroxisomal acyl-CoA thioesterase; likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids; Belongs to the C/M/P thioester hydrolase family.


ensembl_gene_id: YJR020W
symbol: YJR020W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YJR020W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YJR021C
symbol: REC107
gene_biotype: protein_coding
description:
  Recombination protein 107; Protein involved in early stages of meiotic recombination; involved in coordination between the initiation of recombination and the first division of meiosis; part of a complex (Rec107p-Mei4p-Rec114p) required for ds break formation.


ensembl_gene_id: YJR022W
symbol: LSM8
gene_biotype: protein_coding
description:
  U6 snRNA-associated Sm-like protein LSm8; Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) that is part of spliceosomal U6 snRNP and is also implicated in processing of pre-tRNA, pre-snoRNA, and pre-rRNA.


ensembl_gene_id: YJR023C
symbol: YJR023C
gene_biotype: protein_coding
description:
  Putative protein of unknown function; open reading frame overlaps LSM8/YJR022W encoding an essential snRNP protein required for RNA processing and splicing.


ensembl_gene_id: YJR024C
symbol: MDE1
gene_biotype: protein_coding
description:
  5'-methylthioribulose-1-phosphate dehydratase; acts in the methionine salvage pathway; potential Smt3p sumoylation substrate; expression downregulated by caspofungin and deletion mutant is caspofungin resistant; Belongs to the aldolase class II family. MtnB subfamily.


ensembl_gene_id: YJR025C
symbol: BNA1
gene_biotype: protein_coding
description:
  3-hydroxyanthranilate 3,4-dioxygenase; 3-hydroxyanthranilic acid dioxygenase; required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p.


ensembl_gene_id: YJR030C
symbol: RBH2
gene_biotype: protein_coding
description:
  UPF0508 protein YJR030C; Putative protein of unknown function; expression repressed in carbon limited vs carbon replete chemostat cultures; non-essential gene; contains a PH-like domain; RBH2 has a paralog, RBH1, that arose from the whole genome duplication; Belongs to the UPF0508 family.


ensembl_gene_id: YJR031C
symbol: GEA1
gene_biotype: protein_coding
description:
  Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA1 has a paralog, GEA2, that arose from the whole genome duplication.


ensembl_gene_id: YJR032W
symbol: CPR7
gene_biotype: protein_coding
description:
  Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity; plays a role in determining prion variants.


ensembl_gene_id: YJR033C
symbol: RAV1
gene_biotype: protein_coding
description:
  Regulator of V-ATPase in vacuolar membrane protein 1; Subunit of RAVE complex (Rav1p, Rav2p, Skp1p); the RAVE complex promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate.


ensembl_gene_id: YJR034W
symbol: PET191
gene_biotype: protein_coding
description:
  Mitochondrial protein PET191; Protein required for assembly of cytochrome c oxidase; exists as an oligomer; described as both an integral mitochondrial inner membrane protein facing the intermembrane space (IMS) and as a soluble IMS protein; contains a twin Cx9C motif; imported into the IMS via the MIA import machinery.


ensembl_gene_id: YJR035W
symbol: RAD26
gene_biotype: protein_coding
description:
  DNA repair and recombination protein RAD26; Protein involved in transcription-coupled nucleotide excision repair; repairs UV-induced DNA lesions; recruitment to DNA lesions is dependent on an elongating RNA polymerase II; homolog of human CSB protein; Belongs to the SNF2/RAD54 helicase family.


ensembl_gene_id: YJR036C
symbol: HUL4
gene_biotype: protein_coding
description:
  Protein with similarity to hect domain E3 ubiquitin-protein ligases; not essential for viability; found in association with Trf4 in TRAMP complex; Belongs to the HUL4 family.


ensembl_gene_id: YJR037W
symbol: YJR037W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YJR037W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified gene HUL4/YJR036C; deletion mutant has decreased spore survival in Drosophila feces.


ensembl_gene_id: YJR038C
symbol: YJR038C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YJR038C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YJR039W
symbol: YJR039W
gene_biotype: protein_coding
description:
  Uncharacterized protein YJR039W; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies.


ensembl_gene_id: YJR040W
symbol: GEF1
gene_biotype: protein_coding
description:
  Anion/proton exchange transporter GEF1; Voltage-gated chloride channel; localized to the golgi, the endosomal system, and plasma membrane; involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels; modulates TBSV model (+) RNA virus replication by regulating copper metabolism.


ensembl_gene_id: YJR041C
symbol: URB2
gene_biotype: protein_coding
description:
  Protein required for normal metabolism of the rRNA primary transcript; nucleolar protein; proposed to be involved in ribosome biogenesis.


ensembl_gene_id: YJR042W
symbol: NUP85
gene_biotype: protein_coding
description:
  Nucleoporin NUP85; Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP85 aka NUP75.


ensembl_gene_id: YJR043C
symbol: POL32
gene_biotype: protein_coding
description:
  Third subunit of DNA polymerase delta; involved in chromosomal DNA replication; required for error-prone DNA synthesis in the presence of DNA damage and processivity; forms a complex with Rev3p, Rev7p and Pol31p; interacts with Hys2p, PCNA (Pol30p), and Pol1p.


ensembl_gene_id: YJR044C
symbol: VPS55
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 55; Late endosomal protein involved in late endosome to vacuole transport; functional homolog of human obesity receptor gene-related protein (OB-RGRP); Belongs to the OB-RGRP/VPS55 family.


ensembl_gene_id: YJR045C
symbol: SSC1
gene_biotype: protein_coding
description:
  Heat shock protein SSC1, mitochondrial; Hsp70 family ATPase; constituent of the import motor component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in protein translocation and folding; subunit of SceI endonuclease; SSC1 has a paralog, ECM10, that arose from the whole genome duplication.


ensembl_gene_id: YJR046W
symbol: TAH11
gene_biotype: protein_coding
description:
  Cell division cycle protein CDT1; DNA replication licensing factor; required for pre-replication complex assembly; Belongs to the Cdt1 family.


ensembl_gene_id: YJR047C
symbol: ANB1
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 5A-2; Translation elongation factor eIF-5A; previously thought to function in translation initiation; undergoes an essential hypusination modification; expressed under anaerobic conditions; ANB1 has a paralog, HYP2, that arose from the whole genome duplication; human EIF5A complements the inviability of the yeast hyp2 anb1 double null mutant.


ensembl_gene_id: YJR048W
symbol: CYC1
gene_biotype: protein_coding
description:
  Cytochrome c, isoform 1; also known as iso-1-cytochrome c; electron carrier of mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; CYC1 has a paralog, CYC7, that arose from the whole genome duplication; human homolog CYC1 can complement yeast null mutant; mutations in human CYC1 cause insulin-responsive hyperglycemia.


ensembl_gene_id: YJR049C
symbol: UTR1
gene_biotype: protein_coding
description:
  ATP-NADH kinase; phosphorylates both NAD and NADH; active as a hexamer; enhances the activity of ferric reductase (Fre1p); UTR1 has a paralog, YEF1, that arose from the whole genome duplication.


ensembl_gene_id: YJR050W
symbol: ISY1
gene_biotype: protein_coding
description:
  Pre-mRNA-splicing factor ISY1; Member of the NineTeen Complex (NTC); NTC contains Prp19p and stabilizes U6 snRNA in catalytic forms of spliceosome containing U2, U5, and U6 snRNAs; interacts with Prp16p to modulate splicing fidelity; isy1 syf2 cells have defective spindles.


ensembl_gene_id: YJR051W
symbol: OSM1
gene_biotype: protein_coding
description:
  Fumarate reductase, catalyzes the reduction of fumarate to succinate; required for the reoxidation of intracellular NADH under anaerobic conditions; mutations cause osmotic sensitivity; has two translation start sites, one at the annotated start codon which produces an ER-targeted form required for anaerobic growth, and one at codon 32 which produces a mitochondrially-targeted form; OSM1 has a paralog, FRD1, that arose from the whole genome duplication; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.


ensembl_gene_id: YJR052W
symbol: RAD7
gene_biotype: protein_coding
description:
  Nucleotide excision repair (NER) protein; binds damaged DNA during NER; binds DNA in an ATP-dependent manner (with Rad16p) during NER; required for repair of non-transcribed chromatin; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex.


ensembl_gene_id: YJR053W
symbol: BFA1
gene_biotype: protein_coding
description:
  Mitotic check point protein BFA1; Subunit of a two-component GTPase-activating protein, Bfa1p-Bub2p; contributes to GAP activity, inactivating Tem1 by stimulating GTP hydrolysis following damage or misalignment of the mitotic spindle; functions as a guanine-nucleotide exchange inhibitor (GDI) for Tem1p; involved in multiple cell cycle checkpoint pathways that control mitotic exit; required when telomeres are damaged, but not for all types of chromosomal DNA damage; phosphorylated by the Polo-like kinase Cdc5p; To S.pombe byr4.


ensembl_gene_id: YJR054W
symbol: KCH1
gene_biotype: protein_coding
description:
  Uncharacterized vacuolar membrane protein YJR054W; Potassium transporter that mediates K+ influx; activates high-affinity Ca2+ influx system (HACS) during mating pheromone response; expression up-regulated in response to alpha factor; localized to sites of polarized growth; member of a fungal-specific gene family; potential Cdc28p substrate; KCH1 has a paralog, PRM6, that arose from the whole genome duplication; To yeast YML047c.


ensembl_gene_id: YJR055W
symbol: HIT1
gene_biotype: protein_coding
description:
  Protein involved in C/D snoRNP assembly; regulates abundance of Rsa1p; required for growth at high temperature; similar to human ZNHIT3.


ensembl_gene_id: YJR056C
symbol: YJR056C
gene_biotype: protein_coding
description:
  Uncharacterized protein YJR056C; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress.


ensembl_gene_id: YJR057W
symbol: CDC8
gene_biotype: protein_coding
description:
  Thymidylate and uridylate kinase; functions in de novo biosynthesis of pyrimidine deoxyribonucleotides; converts dTMP to dTDP and dUMP to dUTP; essential for mitotic and meiotic DNA replication; homologous to S. pombe tmp1; human homolog DTYMK can complement yeast cdc8 null mutant.


ensembl_gene_id: YJR058C
symbol: APS2
gene_biotype: protein_coding
description:
  AP-2 complex subunit sigma; Small subunit of the clathrin-associated adaptor complex AP-2; AP-2 is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex.


ensembl_gene_id: YJR059W
symbol: PTK2
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase PTK2/STK2; Serine/threonine protein kinase; involved in regulation of ion transport across plasma membrane; carboxyl terminus is essential for glucose-dependent Pma1p activation via phosphorylation of Pma1p-Ser899; enhances spermine uptake; PTK2 has a paralog, PTK1, that arose from the whole genome duplication.


ensembl_gene_id: YJR060W
symbol: CBF1
gene_biotype: protein_coding
description:
  Centromere-binding protein 1; Basic helix-loop-helix (bHLH) protein; forms homodimer to bind E-box consensus sequence CACGTG present at MET gene promoters and centromere DNA element I (CDEI); affects nucleosome positioning at this motif; associates with other transcription factors such as Met4p and Isw1p to mediate transcriptional activation or repression; associates with kinetochore proteins, required for chromosome segregation; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YJR061W
symbol: YJR061W
gene_biotype: protein_coding
description:
  Uncharacterized protein YJR061W; Putative protein of unknown function; non-essential gene; transcription repressed by Rm101p; YJR061W has a paralog, MNN4, that arose from the whole genome duplication; To yeast MNN4.


ensembl_gene_id: YJR062C
symbol: NTA1
gene_biotype: protein_coding
description:
  Amidase; removes the amide group from N-terminal asparagine and glutamine residues to generate proteins with N-terminal aspartate and glutamate residues that are targets of ubiquitin-mediated degradation; Belongs to the carbon-nitrogen hydrolase superfamily.


ensembl_gene_id: YJR063W
symbol: RPA12
gene_biotype: protein_coding
description:
  RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex; physically interacts with transcriptional activator Msn4p, to regulate transcription of AYR1, a gene involved in lipid metabolism; Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.


ensembl_gene_id: YJR064W
symbol: CCT5
gene_biotype: protein_coding
description:
  T-complex protein 1 subunit epsilon; Subunit of the cytosolic chaperonin Cct ring complex; related to Tcp1p, required for the assembly of actin and tubulins in vivo.


ensembl_gene_id: YJR065C
symbol: ARP3
gene_biotype: protein_coding
description:
  Actin-related protein 3; Essential component of the Arp2/3 complex; Arp2/3 is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity.


ensembl_gene_id: YJR066W
symbol: TOR1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase TOR1; PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication; Belongs to the PI3/PI4-kinase family.


ensembl_gene_id: YJR067C
symbol: YAE1
gene_biotype: protein_coding
description:
  Protein that forms a complex with Lto1p and Rli1p; essential for growth under standard (aerobic) conditions but not under anaerobic conditions; may have a role in protection of ribosomal assembly and function from damage due to reactive oxygen species.


ensembl_gene_id: YJR069C
symbol: HAM1
gene_biotype: protein_coding
description:
  Inosine triphosphate pyrophosphatase; Nucleoside triphosphate pyrophosphohydrolase; active against various substrates including ITP, dITP and XTP; mediates exclusion of non canonical purines, pyrimidines from dNTP pools; functions with YJL055W to mediate resistance to 5-FU; specifically reduces the incorporation of 5-FU into RNA without affecting uptake or incorporation of uracil into RNA; protein abundance increases in response to DNA replication stress; yeast HAM1 can complement knockdown of human homolog ITPA.


ensembl_gene_id: YJR070C
symbol: LIA1
gene_biotype: protein_coding
description:
  Deoxyhypusine hydroxylase; HEAT-repeat containing metalloenzyme that catalyzes hypusine formation; binds to and is required for the modification of Hyp2p (eIF5A); complements S. pombe mmd1 mutants defective in mitochondrial positioning; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YJR071W
symbol: YJR071W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YJR071W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YJR072C
symbol: NPA3
gene_biotype: protein_coding
description:
  GPN-loop GTPase 1; Member of the conserved GPN-loop GTPase family; has a role in transport of RNA polymerase II to the nucleus; exhibits GTP-dependent binding to PolII; has ATPase activity; involved in sister chromatid cohesion; phosphorylated by the Pcl1p-Pho85p kinase complex; human homolog XAB1 interacts with human RNA polymerase II; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YJR073C
symbol: OPI3
gene_biotype: protein_coding
description:
  Phosphatidyl-N-methylethanolamine N-methyltransferase; Methylene-fatty-acyl-phospholipid synthase; catalyzes the last two steps in phosphatidylcholine biosynthesis; also known as phospholipid methyltransferase.


ensembl_gene_id: YJR074W
symbol: MOG1
gene_biotype: protein_coding
description:
  Conserved nuclear protein that interacts with GTP-Gsp1p; stimulates nucleotide release from Gsp1p; involved in nuclear protein import; nucleotide release is inhibited by Yrb1p.


ensembl_gene_id: YJR075W
symbol: HOC1
gene_biotype: protein_coding
description:
  Putative glycosyltransferase HOC1; Alpha-1,6-mannosyltransferase; involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele.


ensembl_gene_id: YJR076C
symbol: CDC11
gene_biotype: protein_coding
description:
  Cell division control protein 11; Component of the septin ring that is required for cytokinesis; present at the ends of rod-like septin hetero-oligomers; C-terminal extension is important for recruitment of Bni5p to the mother-bud neck, which in turn is required for Myo1p recruitment and cytokinesis; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.


ensembl_gene_id: YJR077C
symbol: MIR1
gene_biotype: protein_coding
description:
  Mitochondrial phosphate carrier; imports inorganic phosphate into mitochondria; functionally redundant with Pic2p but more abundant than Pic2p under normal conditions; phosphorylated; Belongs to the mitochondrial carrier (TC 2.A.29) family.


ensembl_gene_id: YJR078W
symbol: BNA2
gene_biotype: protein_coding
description:
  Tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase; required for de novo biosynthesis of NAD from tryptophan via kynurenine; interacts genetically with telomere capping gene CDC13; regulated by Hst1p and Aftp.


ensembl_gene_id: YJR079W
symbol: YJR079W
gene_biotype: protein_coding
description:
  Uncharacterized protein YJR079W; Putative protein of unknown function; mutation results in impaired mitochondrial respiration.


ensembl_gene_id: YJR080C
symbol: AIM24
gene_biotype: protein_coding
description:
  Altered inheritance of mitochondria protein 24, mitochondrial; Protein with a role in determining mitochondrial architecture; inner membrane protein that interacts physically and genetically with the MICOS complex and is required for its integrity.


ensembl_gene_id: YJR082C
symbol: EAF6
gene_biotype: protein_coding
description:
  Chromatin modification-related protein EAF6; Subunit of the NuA4 acetyltransferase complex; this complex acetylates histone H4 and NuA3 acetyltransferase complex that acetylates histone H3; Belongs to the EAF6 family.


ensembl_gene_id: YJR083C
symbol: ACF4
gene_biotype: protein_coding
description:
  Assembly-complementing factor 4; Protein of unknown function; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin cytoskeleton organization; potential Cdc28p substrate.


ensembl_gene_id: YJR084W
symbol: YJR084W
gene_biotype: protein_coding
description:
  Cop9 signalosome complex subunit 12; Protein that forms a complex with Thp3p; may have a role in transcription elongation and/or mRNA splicing; identified as a COP9 signalosome component but phenotype and interactions suggest it may not be involved with the signalosome.


ensembl_gene_id: YJR085C
symbol: YJR085C
gene_biotype: protein_coding
description:
  TMEM14 protein homolog YJR085C; Protein of unknown function; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YJR086W
symbol: STE18
gene_biotype: protein_coding
description:
  G protein gamma subunit; forms a dimer with Ste4p to activate the mating signaling pathway, forms a heterotrimer with Gpa1p and Ste4p to dampen signaling; C-terminus is palmitoylated and farnesylated, which are required for normal signaling.


ensembl_gene_id: YJR087W
symbol: YJR087W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YJR087W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; partially overlaps the verified genes STE18 and ECM2.


ensembl_gene_id: YJR088C
symbol: EMC2
gene_biotype: protein_coding
description:
  Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm Y57G7A.10/EMC-2, fly CG17556, human TTC35.


ensembl_gene_id: YJR089W
symbol: BIR1
gene_biotype: protein_coding
description:
  Protein BIR1; Subunit of chromosomal passenger complex (CPC); CPC is comprised of Ipl1p-Sli15p-Bir1p-Nbl1p and regulates chromosome segregation; required for chromosome bi-orientation and for spindle assembly checkpoint activation upon reduced sister kinetochore tension; relative distribution to shortened microtubules increases upon DNA replication stress; sumoylated in an Mms21p-dependent manner; human survivin homolog.


ensembl_gene_id: YJR090C
symbol: GRR1
gene_biotype: protein_coding
description:
  F-box protein component of an SCF ubiquitin-ligase complex; modular substrate specificity factor which associates with core SCF (Cdc53p, Skp1p and Hrt1p/Rbx1p) to form the SCF(Grr1) complex; SCF(Grr1) acts as a ubiquitin-protein ligase directing ubiquitination of substrates such as: Gic2p, Mks1p, Mth1p, Cln1p, Cln2p and Cln3p; involved in carbon catabolite repression, glucose-dependent divalent cation transport, glucose transport, morphogenesis, and sulfite detoxification.


ensembl_gene_id: YJR091C
symbol: JSN1
gene_biotype: protein_coding
description:
  Protein JSN1; Member of the Puf family of RNA-binding proteins; interacts with mRNAs encoding membrane-associated proteins; involved in localizing the Arp2/3 complex to mitochondria; overexpression causes increased sensitivity to benomyl; JSN1 has a paralog, PUF2, that arose from the whole genome duplication.


ensembl_gene_id: YJR092W
symbol: BUD4
gene_biotype: protein_coding
description:
  Anillin-like protein involved in bud-site selection; required for the axial budding pattern; required for the formation and disassembly of the double septin ring structure, and generally for septin organization; functions as a platform linking the cytokinesis tag septins to the axial landmark through its multiple domains; in vivo substrate of Cdc28p/Clb2p.


ensembl_gene_id: YJR093C
symbol: FIP1
gene_biotype: protein_coding
description:
  Subunit of cleavage polyadenylation factor (CPF); interacts directly with poly(A) polymerase (Pap1p) to regulate its activity; bridging factor that links Pap1p and the CPF complex via Yth1p; Belongs to the FIP1 family.


ensembl_gene_id: YJR094C
symbol: IME1
gene_biotype: protein_coding
description:
  Meiosis-inducing protein 1; Master regulator of meiosis that is active only during meiotic events; activates transcription of early meiotic genes through interaction with Ume6p; degraded by the 26S proteasome following phosphorylation by Ime2p; transcription is negatively regulated in cis by the IRT1 long noncoding antisense RNA.


ensembl_gene_id: YJR094W-A
symbol: RPL43B
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L43B; homologous to mammalian ribosomal protein L37A, no bacterial homolog; RPL43B has a paralog, RPL43A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YJR095W
symbol: SFC1
gene_biotype: protein_coding
description:
  Mitochondrial succinate-fumarate transporter; transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization.


ensembl_gene_id: YJR096W
symbol: YJR096W
gene_biotype: protein_coding
description:
  Uncharacterized oxidoreductase YJR096W; Xylose and arabinose reductase; member of the aldo-keto reductase (AKR) family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS.


ensembl_gene_id: YJR097W
symbol: JJJ3
gene_biotype: protein_coding
description:
  Diphthamide biosynthesis protein 4; Protein of unknown function; contains a CSL Zn finger and a DnaJ-domain; involved in diphthamide biosynthesis; ortholog human Dph4; Belongs to the DPH4 family.


ensembl_gene_id: YJR098C
symbol: YJR098C
gene_biotype: protein_coding
description:
  Uncharacterized protein YJR098C; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies.


ensembl_gene_id: YJR099W
symbol: YUH1
gene_biotype: protein_coding
description:
  Ubiquitin C-terminal hydrolase; cleaves ubiquitin-protein fusions to generate monomeric ubiquitin; hydrolyzes the peptide bond at the C-terminus of ubiquitin; also the major processing enzyme for the ubiquitin-like protein Rub1p; Belongs to the peptidase C12 family.


ensembl_gene_id: YJR100C
symbol: AIM25
gene_biotype: protein_coding
description:
  Altered inheritance rate of mitochondria protein 25; Mitochondria protein of unknown function; interacts genetically with TOR1 to regulate chronological lifespan, and the response to both heat shock and oxidative stress; involved in maintaining the integrity of the mitochondrial network; negative regulator of mitophagy flux; non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant is viable and displays an elevated frequency of mitochondrial genome loss; similar to murine NOR1.


ensembl_gene_id: YJR102C
symbol: VPS25
gene_biotype: protein_coding
description:
  Vacuolar protein-sorting-associated protein 25; Component of the ESCRT-II complex; ESCRT-II is involved in ubiquitin-dependent sorting of proteins into the endosome; Belongs to the VPS25 family.


ensembl_gene_id: YJR103W
symbol: URA8
gene_biotype: protein_coding
description:
  Minor CTP synthase isozyme (see also URA7); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA8 has a paralog, URA7, that arose from the whole genome duplication.


ensembl_gene_id: YJR104C
symbol: SOD1
gene_biotype: protein_coding
description:
  Cytosolic copper-zinc superoxide dismutase; detoxifies superoxide; stabilizes Yck1p and Yck2p kinases in glucose to repress respiration; phosphorylated by Dun1p, enters nucleus under oxidative stress to promote transcription of stress response genes; human ortholog SOD1 implicated in ALS complements a null allele; abundance increases under DNA replication stress and during exposure to boric acid; localization to mitochondrial intermembrane space is modulated by MICOS complex; Belongs to the Cu-Zn superoxide dismutase family.


ensembl_gene_id: YJR105W
symbol: ADO1
gene_biotype: protein_coding
description:
  Adenosine kinase; required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle.


ensembl_gene_id: YJR106W
symbol: ECM27
gene_biotype: protein_coding
description:
  Protein involved in calcium homeostasis and exit from quiescence; required for proper trehalose levels during quiescence; may play a role in cell wall biosynthesis, mutants are hypersensitive to antifungal, Papulacandin B; null mutants have increased plasmid loss; interacts with Pdr5p.


ensembl_gene_id: YJR108W
symbol: ABM1
gene_biotype: protein_coding
description:
  Aberrant microtubules protein 1; Protein of unknown function; required for normal microtubule organization.


ensembl_gene_id: YJR109C
symbol: CPA2
gene_biotype: protein_coding
description:
  Carbamoyl-phosphate synthase arginine-specific large chain; Large subunit of carbamoyl phosphate synthetase; carbamoyl phosphate synthetase catalyzes a step in the synthesis of citrulline, an arginine precursor.


ensembl_gene_id: YJR110W
symbol: YMR1
gene_biotype: protein_coding
description:
  Phosphoinositide 3-phosphatase; Phosphatidylinositol 3-phosphate (PI3P) phosphatase; involved in various protein sorting pathways, including CVT targeting and endosome to vacuole transport; has similarity to the conserved myotubularin dual specificity phosphatase family; Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily.


ensembl_gene_id: YJR111C
symbol: PXP2
gene_biotype: protein_coding
description:
  Uncharacterized protein YJR111C; Peroxisomal matrix protein with naturally active promoter; well-conserved in fungi; localized to peroxisomes under physiological growth conditions; levels of some amino acids are altered upon both knockout and overexpression, suggesting potential involvement of Pxp2p in amino acid metabolism or related cellular metabolic processes (needs further study); GFP-fusion protein displays inherent dual localization with large proportion localizing to cytosol.


ensembl_gene_id: YJR112W
symbol: NNF1
gene_biotype: protein_coding
description:
  Kinetochore-associated protein NNF1; Essential component of the MIND kinetochore complex; joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation; complex consists of Mtw1p Including Nnf1p-Nsl1p-Dsn1p (MIND).


ensembl_gene_id: YJR112W-A
symbol: YJR112W-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YJR112W-A; Putative protein of unknown function; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum; identified based on homology to <i>Ashbya gossypii</i>.


ensembl_gene_id: YJR113C
symbol: RSM7
gene_biotype: protein_coding
description:
  Mitochondrial ribosomal protein of the small subunit; has similarity to E. coli S7 ribosomal protein.


ensembl_gene_id: YJR114W
symbol: YJR114W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YJR114W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSM7/YJR113C.


ensembl_gene_id: YJR115W
symbol: YJR115W
gene_biotype: protein_coding
description:
  Putative protein of unknown function; YJR115W has a paralog, ECM13, that arose from the whole genome duplication.


ensembl_gene_id: YJR116W
symbol: TDA4
gene_biotype: protein_coding
description:
  Topoisomerase I damage affected protein 4; Putative protein of unknown function; null mutant is sensitive to expression of the top1-T722A allele; Belongs to the TMEM56 family.


ensembl_gene_id: YJR117W
symbol: STE24
gene_biotype: protein_coding
description:
  CAAX prenyl protease 1; Highly conserved zinc metalloprotease; functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; cleaves both isoprenylated and non-prenylated oligopeptides; contains multiple transmembrane spans; human homolog ZMPSTE24 implicated in mandibuloacral dysplasia (MAD), and can complement yeast null mutant.


ensembl_gene_id: YJR118C
symbol: ILM1
gene_biotype: protein_coding
description:
  Protein of unknown function; may be involved in mitochondrial DNA maintenance; required for slowed DNA synthesis-induced filamentous growth.


ensembl_gene_id: YJR119C
symbol: JHD2
gene_biotype: protein_coding
description:
  JmjC domain family histone demethylase; promotes global demethylation of H3K4 and repression of noncoding intergenic transcription during sporulation; removes methyl groups added by Set1p methyltransferase; negatively regulated by H3K14 acetylation; protein levels regulated by Not4p polyubiquitin-mediated degradation; regulates sporulation timing by extending period of active transcription in opposition to programmed global transcriptional quiescence; regulates rDNA silencing.


ensembl_gene_id: YJR120W
symbol: YJR120W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YJR120W; Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p.


ensembl_gene_id: YJR121W
symbol: ATP2
gene_biotype: protein_coding
description:
  Beta subunit of the F1 sector of mitochondrial F1F0 ATP synthase; which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; F1 translationally regulates ATP6 and ATP8 expression to achieve a balanced output of ATP synthase genes encoded in nucleus and mitochondria; phosphorylated; Belongs to the ATPase alpha/beta chains family.


ensembl_gene_id: YJR122W
symbol: IBA57
gene_biotype: protein_coding
description:
  Putative transferase CAF17, mitochondrial; Protein involved in incorporating iron-sulfur clusters into proteins; mitochondrial matrix protein; involved in the incorporation of iron-sulfur clusters into mitochondrial aconitase-type proteins; activates the radical-SAM family members Bio2p and Lip5p; interacts with Ccr4p in the two-hybrid system.


ensembl_gene_id: YJR123W
symbol: RPS5
gene_biotype: protein_coding
description:
  Protein component of the small (40S) ribosomal subunit; least basic of non-acidic ribosomal proteins; phosphorylated in vivo; essential for viability; homologous to mammalian ribosomal protein S5 and bacterial S7.


ensembl_gene_id: YJR124C
symbol: YJR124C
gene_biotype: protein_coding
description:
  Uncharacterized membrane protein YJR124C; Putative protein of unknown function; expression induced under calcium shortage.


ensembl_gene_id: YJR125C
symbol: ENT3
gene_biotype: protein_coding
description:
  Epsin-3; Protein containing an N-terminal epsin-like domain; involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p.


ensembl_gene_id: YJR126C
symbol: VPS70
gene_biotype: protein_coding
description:
  Protein of unknown function involved in vacuolar protein sorting; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum; Belongs to the peptidase M28 family. M28B subfamily.


ensembl_gene_id: YJR127C
symbol: RSF2
gene_biotype: protein_coding
description:
  Respiration factor 2; Zinc-finger protein; involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions; RSF2 has a paralog, TDA9, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasm upon DNA replication stress; Belongs to the RSF2/TDA9 family.


ensembl_gene_id: YJR128W
symbol: YJR128W
gene_biotype: protein_coding
description:
  Uncharacterized protein YJR128W; Putative protein of unknown function; conserved among S. cerevisiae strains; partially overlaps the verified ORF RSF2.


ensembl_gene_id: YJR129C
symbol: EFM3
gene_biotype: protein_coding
description:
  Protein-lysine N-methyltransferase EFM3; S-adenosylmethionine-dependent methyltransferase; seven-beta-strand lysine methyltransferase which trimethylates translation elongation factor EF2 (Eft1p and Eft2p) at lysine 509; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; ortholog of human gene FAM86A; Belongs to the class I-like SAM-binding methyltransferase superfamily. EEF2KMT family.


ensembl_gene_id: YJR130C
symbol: STR2
gene_biotype: protein_coding
description:
  Cystathionine gamma-synthase, converts cysteine into cystathionine; STR2 has a paralog, YML082W, that arose from the whole genome duplication; Belongs to the trans-sulfuration enzymes family. MET7 subfamily.


ensembl_gene_id: YJR131W
symbol: MNS1
gene_biotype: protein_coding
description:
  Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase; Alpha-1,2-mannosidase; involved in ER-associated protein degradation (ERAD); catalyzes the removal of one mannose residue from a glycosylated protein, converting the modification from Man9GlcNAc to Man8GlcNAc; catalyzes the last step in glycoprotein maturation in the ER and is critical for ER protein degradation.


ensembl_gene_id: YJR132W
symbol: NMD5
gene_biotype: protein_coding
description:
  Nonsense-mediated mRNA decay protein 5; Karyopherin; a carrier protein involved in nuclear import of proteins; importin beta homolog.


ensembl_gene_id: YJR133W
symbol: XPT1
gene_biotype: protein_coding
description:
  Xanthine phosphoribosyltransferase 1; Xanthine-guanine phosphoribosyl transferase; required for xanthine utilization and for optimal utilization of guanine.


ensembl_gene_id: YJR134C
symbol: SGM1
gene_biotype: protein_coding
description:
  Protein of unknown function; required for wild-type growth rate on galactose and mannose; localizes to COPI coated vesicles and the Golgi apparatus; Belongs to the SGM1 family.


ensembl_gene_id: YJR135C
symbol: MCM22
gene_biotype: protein_coding
description:
  Inner kinetochore subunit MCM22; Outer kinetochore protein and component of the Ctf3 subcomplex; binds to centromeric DNA in a Ctf19p-dependent manner; involved in chromosome segregation and minichromosome maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-K and fission yeast sim4.


ensembl_gene_id: YJR135W-A
symbol: TIM8
gene_biotype: protein_coding
description:
  Mitochondrial import inner membrane translocase subunit TIM8; Mitochondrial intermembrane space protein; forms a complex with Tim13p that delivers a subset of hydrophobic proteins to the TIM22 complex for inner membrane insertion; homolog of human TIMM8A, implicated in Mohr-Tranebjaerg syndrome, also known as deafness-dystonia-optic neuronopathy (DDON) syndrome; human TIMM8A can complement yeast null mutant.


ensembl_gene_id: YJR136C
symbol: TTI2
gene_biotype: protein_coding
description:
  TEL2-interacting protein 2; Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1; involved in the cellular stress response; similar to S. pombe Tti2p; may interact with Rsm23p; GFP-fusion protein localizes to the cytoplasm.


ensembl_gene_id: YJR137C
symbol: MET5
gene_biotype: protein_coding
description:
  Sulfite reductase beta subunit; involved in amino acid biosynthesis, transcription repressed by methionine; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.


ensembl_gene_id: YJR138W
symbol: IML1
gene_biotype: protein_coding
description:
  GTPase-activating protein (GAP) subunit of the Iml1p/SEACIT complex; SEACIT (Iml1p-Npr2p-Npr3p) is a subcomplex of the SEA complex, a coatomer-related complex that associates dynamically with the vacuole; Iml1p functions in the SEACIT complex as a GAP for the Rag family GTPase Gtr1p (EGOC subunit), resulting in the inhibition of TORC1 signaling in response to amino acid deprivation; the Iml1p/SEACIT complex is required for non-nitrogen-starvation (NNS)-induced autophagy.


ensembl_gene_id: YJR139C
symbol: HOM6
gene_biotype: protein_coding
description:
  Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase); dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions.


ensembl_gene_id: YJR140C
symbol: HIR3
gene_biotype: protein_coding
description:
  Histone transcription regulator 3; Subunit of the HIR complex; a nucleosome assembly complex involved in regulation of histone gene transcription; involved in position-dependent gene silencing and nucleosome reassembly; ortholog of human CABIN1 protein.


ensembl_gene_id: YJR140W-A
symbol: YJR140W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YJR140W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified gene HIR3; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching.


ensembl_gene_id: YJR142W
symbol: YJR142W
gene_biotype: protein_coding
description:
  Uncharacterized protein YJR142W; 8-oxo-dGTP diphosphatase of the Nudix hydrolase family; converts diphosphates of damaged forms of thiamin to monophosphates; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition.


ensembl_gene_id: YJR143C
symbol: PMT4
gene_biotype: protein_coding
description:
  Dolichyl-phosphate-mannose--protein mannosyltransferase 4; Protein O-mannosyltransferase; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; appears to form homodimers in vivo and does not complex with other Pmt proteins; target for new antifungals.


ensembl_gene_id: YJR144W
symbol: MGM101
gene_biotype: protein_coding
description:
  Mitochondrial genome maintenance protein MGM101; Protein with a role in mitochondrial DNA recombinational repair; also involved in interstrand cross-link repair; binds to and catalyzes the annealing of single-stranded mtDNA; oligomerizes to form rings and filaments; related to Rad52-type recombination proteins, with limited overall similarity but sharing conserved functionally important residues; component of the mitochondrial nucleoid, required for the repair of oxidative mtDNA damage and mitochondrial genome maintenance; Belongs to the MGM101 family.


ensembl_gene_id: YJR145C
symbol: RPS4A
gene_biotype: protein_coding
description:
  Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4A has a paralog, RPS4B, that arose from the whole genome duplication.


ensembl_gene_id: YJR146W
symbol: YJR146W
gene_biotype: protein_coding
description:
  Uncharacterized protein YJR146W; Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps HMS2.


ensembl_gene_id: YJR147W
symbol: HMS2
gene_biotype: protein_coding
description:
  Protein with similarity to heat shock transcription factors; overexpression suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant; HMS2 has a paralog, SKN7, that arose from the whole genome duplication.


ensembl_gene_id: YJR148W
symbol: BAT2
gene_biotype: protein_coding
description:
  Branched-chain-amino-acid aminotransferase, cytosolic; Cytosolic branched-chain amino acid (BCAA) aminotransferase; preferentially involved in BCAA catabolism; homolog of murine ECA39; highly expressed during stationary phase and repressed during logarithmic phase; BAT2 has a paralog, BAT1, that arose from the whole genome duplication; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.


ensembl_gene_id: YJR149W
symbol: YJR149W
gene_biotype: protein_coding
description:
  Putative nitronate monooxygenase; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm.


ensembl_gene_id: YJR150C
symbol: DAN1
gene_biotype: protein_coding
description:
  Cell wall mannoprotein; has similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth.


ensembl_gene_id: YJR151C
symbol: DAN4
gene_biotype: protein_coding
description:
  Cell wall mannoprotein; has similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth; Belongs to the SRP1/TIP1 family.


ensembl_gene_id: YJR151W-A
symbol: YJR151W-A
gene_biotype: protein_coding
description:
  Putative protein of unknown function; identified by fungal homology and RT-PCR; predicted to have a role in transcription based on computational guilt by association analysis.


ensembl_gene_id: YJR152W
symbol: DAL5
gene_biotype: protein_coding
description:
  Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression; Belongs to the major facilitator superfamily. Allantoate permease family.


ensembl_gene_id: YJR153W
symbol: PGU1
gene_biotype: protein_coding
description:
  Endo-polygalacturonase; pectolytic enzyme that hydrolyzes the alpha-1,4-glycosidic bonds in the rhamnogalacturonan chains in pectins.


ensembl_gene_id: YJR154W
symbol: YJR154W
gene_biotype: protein_coding
description:
  Uncharacterized protein YJR154W; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; Belongs to the PhyH family.


ensembl_gene_id: YJR155W
symbol: AAD10
gene_biotype: protein_coding
description:
  Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role; members of the AAD gene family comprise three pairs (AAD3 + AAD15, AAD6/AAD16 + AAD4, AAD10 + AAD14) whose two genes are more related to one another than to other members of the family; Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.


ensembl_gene_id: YJR156C
symbol: THI11
gene_biotype: protein_coding
description:
  4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase THI11; Protein involved in synthesis of the thiamine precursor HMP; member of a subtelomeric gene family including THI5, THI11, THI12, and THI13; hydroxymethylpyrimidine is also known as HMP.


ensembl_gene_id: YJR157W
symbol: YJR157W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YJR157W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YJR158W
symbol: HXT16
gene_biotype: protein_coding
description:
  Hexose transporter HXT16; Putative transmembrane polyol transporter; supports growth on and uptake of sorbitol with moderate affinity and mannitol with lower affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; similarity to hexose transporters; expression is repressed by high levels of glucose; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.


ensembl_gene_id: YJR159W
symbol: SOR1
gene_biotype: protein_coding
description:
  Sorbitol dehydrogenase; protein sequence is 99% identical to the Sor2p sorbitol dehydrogenase; expression is induced in the presence of sorbitol or xylose; Belongs to the zinc-containing alcohol dehydrogenase family.


ensembl_gene_id: YJR160C
symbol: MPH3
gene_biotype: protein_coding
description:
  Alpha-glucosides permease MPH3; Alpha-glucoside permease; transports maltose, maltotriose, alpha-methylglucoside, and turanose; identical to Mph2p; encoded in a subtelomeric position in a region likely to have undergone duplication.


ensembl_gene_id: YJR162C
symbol: YJR162C
gene_biotype: protein_coding
description:
  Putative UPF0320 protein YJR162C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YKL001C
symbol: MET14
gene_biotype: protein_coding
description:
  Adenylylsulfate kinase; required for sulfate assimilation and involved in methionine metabolism; human homolog PAPSS2 complements yeast null mutant.


ensembl_gene_id: YKL002W
symbol: DID4
gene_biotype: protein_coding
description:
  DOA4-independent degradation protein 4; Class E Vps protein of the ESCRT-III complex; required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies, and for delivery of newly synthesized vacuolar enzymes to the vacuole, involved in endocytosis; Belongs to the SNF7 family.


ensembl_gene_id: YKL003C
symbol: MRP17
gene_biotype: protein_coding
description:
  Mitochondrial ribosomal protein of the small subunit; MRP17 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator.


ensembl_gene_id: YKL004W
symbol: AUR1
gene_biotype: protein_coding
description:
  Inositol phosphorylceramide synthase catalytic subunit AUR1; Phosphatidylinositol:ceramide phosphoinositol transferase; required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance; also known as IPC synthase.


ensembl_gene_id: YKL005C
symbol: BYE1
gene_biotype: protein_coding
description:
  Transcription factor BYE1; Negative regulator of transcription elongation; contains a TFIIS-like domain that associates with chromatin and a PHD domain that interacts with H3K4me3; multicopy suppressor of temperature-sensitive ess1 mutations, binds RNA polymerase II large subunit.


ensembl_gene_id: YKL006C-A
symbol: SFT1
gene_biotype: protein_coding
description:
  Intra-Golgi v-SNARE; required for transport of proteins between an early and a later Golgi compartment.


ensembl_gene_id: YKL006W
symbol: RPL14A
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L14A; N-terminally acetylated; homologous to mammalian ribosomal protein L14, no bacterial homolog; RPL14A has a paralog, RPL14B, that arose from the whole genome duplication.


ensembl_gene_id: YKL007W
symbol: CAP1
gene_biotype: protein_coding
description:
  Alpha subunit of the capping protein heterodimer (Cap1p and Cap2p); capping protein (CP) binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches; protein increases in abundance and relocalizes from bud neck to plasma membrane upon DNA replication stress.


ensembl_gene_id: YKL008C
symbol: LAC1
gene_biotype: protein_coding
description:
  Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lag1p; LAC1 has a paralog, LAG1, that arose from the whole genome duplication.


ensembl_gene_id: YKL009W
symbol: MRT4
gene_biotype: protein_coding
description:
  Protein involved in mRNA turnover and ribosome assembly; required at post-transcriptional step for efficient retrotransposition; localizes to the nucleolus; Belongs to the universal ribosomal protein uL10 family.


ensembl_gene_id: YKL010C
symbol: UFD4
gene_biotype: protein_coding
description:
  Ubiquitin-protein ligase (E3); interacts with Rpt4p and Rpt6p, two subunits of the 19S particle of the 26S proteasome; cytoplasmic E3 involved in the degradation of ubiquitin fusion proteins; relative distribution to the nucleus increases upon DNA replication stress.


ensembl_gene_id: YKL011C
symbol: CCE1
gene_biotype: protein_coding
description:
  Mitochondrial cruciform cutting endonuclease; cleaves Holliday junctions formed during recombination of mitochondrial DNA; CCE1 has a paralog, MRS1, that arose from the whole genome duplication.


ensembl_gene_id: YKL012W
symbol: PRP40
gene_biotype: protein_coding
description:
  Pre-mRNA-processing protein PRP40; U1 snRNP protein involved in splicing; interacts with the branchpoint-binding protein during the formation of the second commitment complex.


ensembl_gene_id: YKL013C
symbol: ARC19
gene_biotype: protein_coding
description:
  Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches; mutation is functionally complemented by human ARPC4.


ensembl_gene_id: YKL014C
symbol: URB1
gene_biotype: protein_coding
description:
  Protein required for the normal accumulation of 25S and 5.8S rRNAs; nucleolar protein; associated with the 27SA2 pre-ribosomal particle; proposed to be involved in the biogenesis of the 60S ribosomal subunit.


ensembl_gene_id: YKL015W
symbol: PUT3
gene_biotype: protein_coding
description:
  Proline utilization trans-activator; Transcriptional activator; binds specific gene recruitment sequences and is required for DNA zip code-mediated targeting of genes to nuclear periphery; regulates proline utilization genes, constitutively binds PUT1 and PUT2 promoters as a dimer, undergoes conformational change to form active state; binds other promoters only under activating conditions; differentially phosphorylated in presence of different nitrogen sources; has a Zn(2)-Cys(6) binuclear cluster domain.


ensembl_gene_id: YKL016C
symbol: ATP7
gene_biotype: protein_coding
description:
  Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis.


ensembl_gene_id: YKL017C
symbol: HCS1
gene_biotype: protein_coding
description:
  Hexameric DNA polymerase alpha-associated DNA helicase A; involved in lagging strand DNA synthesis; contains single-stranded DNA stimulated ATPase and dATPase activities; replication protein A stimulates helicase and ATPase activities.


ensembl_gene_id: YKL018C-A
symbol: YKL018C-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YKL018C-A; Putative protein of unknown function; identified by homology; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm.


ensembl_gene_id: YKL018W
symbol: SWD2
gene_biotype: protein_coding
description:
  COMPASS component SWD2; Subunit of the COMPASS (Set1C) histone H3K4 methyltransferase complex; required for Set1C stability and optimal activity; COMPASS methylates histone H3 on lys 4 and is involved in telomeric silencing; subunit of CPF (cleavage and polyadenylation factor), a complex involved in RNAP II transcription termination; Belongs to the WD repeat SWD2 family.


ensembl_gene_id: YKL019W
symbol: RAM2
gene_biotype: protein_coding
description:
  Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha; Alpha subunit of farnesyltransferase and geranylgeranyltransferase-I; farnesyltransferase (Ram2p-Ram1p heterodimer) catalyzes the addition of 15-carbon isoprenoid farnesyl to substrate proteins containing a CAAX consensus motif; type I geranylgeranyltransferase (Ram2p-Cdc43p heterodimer) catalyzes the addition of the 20-carbon isoprenoid geranylgeranyl to substrate proteins containing a CaaL consensus motif; required for membrane localization of Ras proteins and a-factor.


ensembl_gene_id: YKL020C
symbol: SPT23
gene_biotype: protein_coding
description:
  ER membrane protein involved in regulation of OLE1 transcription; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting; SPT23 has a paralog, MGA2, that arose from the whole genome duplication.


ensembl_gene_id: YKL021C
symbol: MAK11
gene_biotype: protein_coding
description:
  Protein involved in an early step of 60S ribosomal subunit biogenesis; essential for cell growth and replication of killer M1 dsRNA virus; contains four beta-transducin repeats.


ensembl_gene_id: YKL022C
symbol: CDC16
gene_biotype: protein_coding
description:
  Subunit of the anaphase-promoting complex/cyclosome (APC/C); which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; required for sporulation; relocalizes to the cytosol in response to hypoxia.


ensembl_gene_id: YKL023W
symbol: YKL023W
gene_biotype: protein_coding
description:
  Uncharacterized protein YKL023W; Putative protein of unknown function; predicted by computational methods to be involved in mRNA degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm.


ensembl_gene_id: YKL024C
symbol: URA6
gene_biotype: protein_coding
description:
  Uridylate kinase; catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines, converting uridine monophosphate (UMP) into uridine-5'-diphosphate (UDP); Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.


ensembl_gene_id: YKL025C
symbol: PAN3
gene_biotype: protein_coding
description:
  Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex; poly (A) mRNA binding subunit which recruits mRNA to the complex; the Pan2p-Pan3p complex controls poly(A) tail length and regulates the stoichiometry and activity of postreplication repair complexes.


ensembl_gene_id: YKL026C
symbol: GPX1
gene_biotype: protein_coding
description:
  Glutathione peroxidase-like peroxiredoxin 1; Phospholipid hydroperoxide glutathione peroxidase; induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress; GPX1 has a paralog, HYR1, that arose from the whole genome duplication.


ensembl_gene_id: YKL027W
symbol: TCD2
gene_biotype: protein_coding
description:
  tRNA threonylcarbamoyladenosine dehydratase; required for the ct6A tRNA base modification, where an adenosine at position 37 is modified to form a cyclized active ester with an oxazolone ring; localized to the mitochondrial outer membrane; TCD2 has a paralog, TCD1, that arose from the whole genome duplication.


ensembl_gene_id: YKL028W
symbol: TFA1
gene_biotype: protein_coding
description:
  Transcription initiation factor IIE subunit alpha; TFIIE large subunit; involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening.


ensembl_gene_id: YKL029C
symbol: MAE1
gene_biotype: protein_coding
description:
  Mitochondrial malic enzyme; catalyzes the oxidative decarboxylation of malate to pyruvate, which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids.


ensembl_gene_id: YKL030W
symbol: YKL030W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YKL030W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; partially overlaps the verified gene MAE1.


ensembl_gene_id: YKL031W
symbol: YKL031W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YKL031W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species.


ensembl_gene_id: YKL032C
symbol: IXR1
gene_biotype: protein_coding
description:
  Intrastrand cross-link recognition protein; Transcriptional repressor that regulates hypoxic genes during normoxia; involved in the aerobic repression of genes such as COX5b, TIR1, and HEM13; binds DNA intrastrand cross-links formed by cisplatin; HMG (high mobility group box) domain containing protein which binds and bends cisplatin-modified DNA, blocking excision repair; IXR1 has a paralog, ABF2, that arose from the whole genome duplication.


ensembl_gene_id: YKL033W
symbol: TTI1
gene_biotype: protein_coding
description:
  TEL2-interacting protein 1; Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1; similar to S. pombe Tti1p; detected in highly purified mitochondria in high-throughput studies.


ensembl_gene_id: YKL033W-A
symbol: YKL033W-A
gene_biotype: protein_coding
description:
  Uncharacterized hydrolase YKL033W-A; Putative protein of unknown function; similar to uncharacterized proteins from other fungi; Belongs to the HAD-like hydrolase superfamily.


ensembl_gene_id: YKL034W
symbol: TUL1
gene_biotype: protein_coding
description:
  Transmembrane E3 ubiquitin-protein ligase 1; Subunit of the DSC ubiquitin ligase complex; golgi-localized RING-finger ubiquitin ligase (E3) involved in sorting polar transmembrane domain containing membrane proteins to multivesicular bodies for delivery to the vacuole; proposed involvement in the quality control of misfolded TMD containing proteins; ortholog of fission yeast dsc1.


ensembl_gene_id: YKL035W
symbol: UGP1
gene_biotype: protein_coding
description:
  UTP--glucose-1-phosphate uridylyltransferase; UDP-glucose pyrophosphorylase (UGPase); catalyses the reversible formation of UDP-Glc from glucose 1-phosphate and UTP, involved in a wide variety of metabolic pathways, expression modulated by Pho85p through Pho4p; involved in PKA-mediated oxidative stress resistance and long-term survival in stationary phase; UGP1 has a paralog, YHL012W, that arose from the whole genome duplication.


ensembl_gene_id: YKL036C
symbol: YKL036C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YKL036C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; partially overlaps the essential gene UGP1 gene and uncharacterized ORF YKL037W.


ensembl_gene_id: YKL037W
symbol: AIM26
gene_biotype: protein_coding
description:
  Protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss; null mutation confers sensitivity to tunicamycin and DTT.


ensembl_gene_id: YKL038W
symbol: RGT1
gene_biotype: protein_coding
description:
  Glucose-responsive transcription factor; regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor; recruits Tup1p/Cyc8p to target gene promoters; RGT1 has a paralog, EDS1, that arose from the whole genome duplication; Belongs to the EDS1/RGT1 family.


ensembl_gene_id: YKL039W
symbol: PTM1
gene_biotype: protein_coding
description:
  Membrane protein PTM1; Protein of unknown function; copurifies with late Golgi vesicles containing the v-SNARE Tlg2p; PTM1 has a paralog, YHL017W, that arose from the whole genome duplication.


ensembl_gene_id: YKL040C
symbol: NFU1
gene_biotype: protein_coding
description:
  NifU-like protein, mitochondrial; Protein involved in Fe-S cluster transfer to mitochondrial clients; protects [4Fe-4S] clusters from damage due to oxidative stress; acts along with Bol3 at a late step in the transfer of [4Fe-4S] clusters from the ISA complex to client proteins; Fe-S loaded homodimer at steady state; similar to NifU, a bacterial protein required for Fe/S cluster maturation; ortholog of the human NFU1, mutations of which are associated with Multiple Mitochondria Dysfunctions Syndrome (MMDS1).


ensembl_gene_id: YKL041W
symbol: VPS24
gene_biotype: protein_coding
description:
  Vacuolar protein-sorting-associated protein 24; One of four subunits of the ESCRT-III complex; forms an endosomal sorting complex required for transport III (ESCRT-III) subcomplex with Did4p; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway.


ensembl_gene_id: YKL042W
symbol: SPC42
gene_biotype: protein_coding
description:
  Central plaque component of spindle pole body (SPB); involved in SPB duplication, may facilitate attachment of the SPB to the nuclear membrane; Belongs to the SPC42 family.


ensembl_gene_id: YKL043W
symbol: PHD1
gene_biotype: protein_coding
description:
  Putative transcription factor PHD1; Transcriptional activator that enhances pseudohyphal growth; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; regulates expression of FLO11, an adhesin required for pseudohyphal filament formation; similar to StuA, an A. nidulans developmental regulator; potential Cdc28p substrate; PHD1 has a paralog, SOK2, that arose from the whole genome duplication.


ensembl_gene_id: YKL044W
symbol: MMO1
gene_biotype: protein_coding
description:
  Uncharacterized protein YKL044W; Protein of unknown function; SWAT-GFP, seamless-GFP and mCherry fusion proteins localize to the mitochondria; mRNA identified as translated by ribosome profiling data; MMO1 is a non-essential gene.


ensembl_gene_id: YKL045W
symbol: PRI2
gene_biotype: protein_coding
description:
  Subunit of DNA primase; DNA primase is required for DNA synthesis and double-strand break repair; Belongs to the eukaryotic-type primase large subunit family.


ensembl_gene_id: YKL046C
symbol: DCW1
gene_biotype: protein_coding
description:
  Mannan endo-1,6-alpha-mannosidase DCW1; Putative mannosidase; GPI-anchored membrane protein required for cell wall biosynthesis in bud formation;homologous to Dfg5p; Belongs to the glycosyl hydrolase 76 family.


ensembl_gene_id: YKL047W
symbol: ANR2
gene_biotype: protein_coding
description:
  Uncharacterized protein ANR2; Protein of unknown function; may have a role in lipid metabolism, based on localization to lipid droplets; predicted to be palmitoylated.


ensembl_gene_id: YKL048C
symbol: ELM1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase ELM1; Serine/threonine protein kinase; regulates the orientation checkpoint, the morphogenesis checkpoint and the metabolic switch from fermentative to oxidative metabolism by phosphorylating the activation loop of Kin4p, Hsl1p and Snf4p respectively; cooperates with Hsl7p in recruiting Hsl1p to the septin ring, a prerequisite for subsequent recruitment, phosphorylation, and degradation of Swe1p; forms part of the bud neck ring; regulates cytokinesis.


ensembl_gene_id: YKL049C
symbol: CSE4
gene_biotype: protein_coding
description:
  Histone H3-like centromere protein; associated with promoters, accessible chromatin, RNAPII-bound regions; phosphorylated Cse4p associates with centromeres; required for proper kinetochore function; levels regulated by E3 ubiquitin ligase Psh1p; phosphorylation may destabilize defective kinetochores to promote bi-orientation; ubiquitination of N-terminus regulates proteolysis for faithful chromosome segregation; yeast CSE4 can complement mutations in human homolog CENPA.


ensembl_gene_id: YKL050C
symbol: YKL050C
gene_biotype: protein_coding
description:
  Uncharacterized protein YKL050C; Protein of unknown function; the YKL050W protein is a target of the SCFCdc4 ubiquitin ligase complex and YKL050W transcription is regulated by Azf1p; YKL050C has a paralog, EIS1, that arose from the whole genome duplication.


ensembl_gene_id: YKL051W
symbol: SFK1
gene_biotype: protein_coding
description:
  Plasma membrane protein that may act to generate normal levels of PI4P; may act together with or upstream of Stt4p; at least partially mediates proper localization of Stt4p to the plasma membrane; Belongs to the SFK1 family.


ensembl_gene_id: YKL052C
symbol: ASK1
gene_biotype: protein_coding
description:
  Essential subunit of the Dam1 complex (aka DASH complex); couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; phosphorylated during the cell cycle by cyclin-dependent kinases; sumoylated in an Mms21p-dependent manner; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YKL053C-A
symbol: MDM35
gene_biotype: protein_coding
description:
  Mitochondrial distribution and morphology protein 35; Mitochondrial intermembrane space protein; forms complex with Ups2p that transfers phosphatidylserine from outer membrane to inner membrane for phosphatidylethanolamine synthesis; mutation affects mitochondrial distribution and morphology; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YKL053W
symbol: YKL053W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YKL053W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified ORF ASK1.


ensembl_gene_id: YKL054C
symbol: DEF1
gene_biotype: protein_coding
description:
  RNAPII degradation factor; forms a complex with Rad26p in chromatin, enables ubiquitination and proteolysis of RNAPII present in an elongation complex; mutant is deficient in Zip1p loading onto chromosomes during meiosis.


ensembl_gene_id: YKL055C
symbol: OAR1
gene_biotype: protein_coding
description:
  Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase; may comprise a type II mitochondrial fatty acid synthase along with Mct1p; human homolog CBR4 complements yeast null mutant.


ensembl_gene_id: YKL056C
symbol: TMA19
gene_biotype: protein_coding
description:
  Protein that associates with ribosomes; homolog of translationally controlled tumor protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and relocates to the mitochondrial outer surface upon oxidative stress; Belongs to the TCTP family.


ensembl_gene_id: YKL057C
symbol: NUP120
gene_biotype: protein_coding
description:
  Nucleoporin NUP120; Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP160.


ensembl_gene_id: YKL058W
symbol: TOA2
gene_biotype: protein_coding
description:
  TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; required, along with Toa1p, for ribosomal protein gene transcription in vivo; homologous to smallest subunit of human and Drosophila TFIIA; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YKL059C
symbol: MPE1
gene_biotype: protein_coding
description:
  Protein MPE1; Essential conserved subunit of CPF cleavage and polyadenylation factor; plays a role in 3' end formation of mRNA via the specific cleavage and polyadenylation of pre-mRNA; contains a ubiquitin-like (UBL) domain, a RNA-binding zinc knuckle motif and a RING finger domain; both the zinc knuckle and RING finger are required for pre-mRNA binding; possible role in ubiquitination of Pap1p; relocalizes to the cytosol in response to hypoxia.


ensembl_gene_id: YKL060C
symbol: FBA1
gene_biotype: protein_coding
description:
  Fructose 1,6-bisphosphate aldolase; required for glycolysis and gluconeogenesis; catalyzes conversion of fructose 1,6 bisphosphate to glyceraldehyde-3-P and dihydroxyacetone-P; locates to mitochondrial outer surface upon oxidative stress; N-terminally propionylated in vivo; Belongs to the class II fructose-bisphosphate aldolase family.


ensembl_gene_id: YKL061W
symbol: BLI1
gene_biotype: protein_coding
description:
  Subunit of the BLOC-1 complex involved in endosomal maturation; interacts with Msb3p; green fluorescent protein (GFP)-fusion protein localizes to the endosome.


ensembl_gene_id: YKL062W
symbol: MSN4
gene_biotype: protein_coding
description:
  Zinc finger protein MSN4; Stress-responsive transcriptional activator; activated in stochastic pulses of nuclear localization in response to various stress conditions; binds DNA at stress response elements of responsive genes, inducing gene expression; involved in diauxic shift.


ensembl_gene_id: YKL063C
symbol: YKL063C
gene_biotype: protein_coding
description:
  Uncharacterized protein YKL063C; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi.


ensembl_gene_id: YKL064W
symbol: MNR2
gene_biotype: protein_coding
description:
  Manganese resistance protein MNR2; Vacuolar membrane protein required for magnesium homeostasis; putative magnesium transporter; has similarity to Alr1p and Alr2p, which mediate influx of Mg2+ and other divalent cations; localizes to sites of contact between the vacuole and mitochondria (vCLAMPs); Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.


ensembl_gene_id: YKL065C
symbol: YET1
gene_biotype: protein_coding
description:
  Endoplasmic reticulum transmembrane protein; may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein; YET1 has a paralog, YET2, that arose from the whole genome duplication; Belongs to the BCAP29/BCAP31 family.


ensembl_gene_id: YKL065W-A
symbol: YKL065W-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YKL065W-A; Putative protein of unknown function; SWAT-GFP fusion protein localizes to the endoplasmic reticulum (ER) while mCherry fusion localizes to both the ER and vacuole.


ensembl_gene_id: YKL066W
symbol: YKL066W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YKL066W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; partially overlaps the verified gene YNK1.


ensembl_gene_id: YKL067W
symbol: YNK1
gene_biotype: protein_coding
description:
  Nucleoside diphosphate kinase; catalyzes the transfer of gamma phosphates from nucleoside triphosphates, usually ATP, to nucleoside diphosphates by a mechanism that involves formation of an autophosphorylated enzyme intermediate; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YKL068W
symbol: NUP100
gene_biotype: protein_coding
description:
  FG-nucleoporin component of central core of the nuclear pore complex; contributes directly to nucleocytoplasmic transport and maintenance of the nuclear pore complex (NPC) permeability barrier and is involved in gene tethering at the nuclear periphery; NUP100 has a paralog, NUP116, that arose from the whole genome duplication.


ensembl_gene_id: YKL068W-A
symbol: YKL068W-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YKL068W-A; Putative protein of unknown function; identified by homology to <i>Ashbya gossypii</i>.


ensembl_gene_id: YKL069W
symbol: YKL069W
gene_biotype: protein_coding
description:
  Methionine-R-sulfoxide reductase; reduces the R enantiomer of free Met-SO, in contrast to Ycl033Cp which reduces Met-R-SO in a peptide linkage; has a role in protection against oxidative stress; relative distribution to the nucleus increases upon DNA replication stress.


ensembl_gene_id: YKL070W
symbol: YKL070W
gene_biotype: protein_coding
description:
  Uncharacterized protein YKL070W; Putative protein of unknown function; expression induced in cells treated with mycotoxins patulin or citrinin; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies.


ensembl_gene_id: YKL071W
symbol: YKL071W
gene_biotype: protein_coding
description:
  Uncharacterized oxidoreductase YKL071W; Putative protein of unknown function; expression induced in cells treated with the mycotoxin patulin, and also the quinone methide triterpene celastrol; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm.


ensembl_gene_id: YKL072W
symbol: STB6
gene_biotype: protein_coding
description:
  Protein that binds Sin3p in a two-hybrid assay; STB6 has a paralog, STB2, that arose from the whole genome duplication; To yeast STB2.


ensembl_gene_id: YKL073W
symbol: LHS1
gene_biotype: protein_coding
description:
  Heat shock protein 70 homolog LHS1; Molecular chaperone of the endoplasmic reticulum lumen; involved in polypeptide translocation and folding; nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p; regulated by the unfolded protein response pathway.


ensembl_gene_id: YKL074C
symbol: MUD2
gene_biotype: protein_coding
description:
  Splicing factor MUD2; Protein involved in early pre-mRNA splicing; component of the pre-mRNA-U1 snRNP complex, the commitment complex; interacts with Msl5p/BBP splicing factor and Sub2p; similar to metazoan splicing factor U2AF65.


ensembl_gene_id: YKL075C
symbol: YKL075C
gene_biotype: protein_coding
description:
  Uncharacterized protein YKL075C; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; proposed to be involved in resistance to streptozotocin and camptothecin.


ensembl_gene_id: YKL076C
symbol: PSY1
gene_biotype: protein_coding
description:
  Putative platinum sensitivity protein 1; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C.


ensembl_gene_id: YKL077W
symbol: YKL077W
gene_biotype: protein_coding
description:
  PMA1 stabilization in the Golgi protein 1; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole.


ensembl_gene_id: YKL078W
symbol: DHR2
gene_biotype: protein_coding
description:
  Predominantly nucleolar DEAH-box ATP-dependent RNA helicase; required for 18S rRNA synthesis; Belongs to the DEAD box helicase family. DEAH subfamily.


ensembl_gene_id: YKL079W
symbol: SMY1
gene_biotype: protein_coding
description:
  Kinesin-related protein SMY1; Kinesin-like myosin passenger-protein; interacts with Myo2p and enhances its interaction with Sec4p during transport of secretory vesicles; controls actin cable structure and dynamics.


ensembl_gene_id: YKL080W
symbol: VMA5
gene_biotype: protein_coding
description:
  Subunit C of the V1 peripheral membrane domain of V-ATPase; part of the electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane; the V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase) has eight subunits.


ensembl_gene_id: YKL081W
symbol: TEF4
gene_biotype: protein_coding
description:
  Gamma subunit of translational elongation factor eEF1B; stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing eEF1A (Tef1p/Tef2p) from the ribosomal complex.


ensembl_gene_id: YKL082C
symbol: RRP14
gene_biotype: protein_coding
description:
  Essential protein, constituent of 66S pre-ribosomal particles; interacts with proteins involved in ribosomal biogenesis and cell polarity; member of the SURF-6 family; Belongs to the SURF6 family.


ensembl_gene_id: YKL083W
symbol: YKL083W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YKL083W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; partially overlaps the verified essential gene RRP14.


ensembl_gene_id: YKL084W
symbol: HOT13
gene_biotype: protein_coding
description:
  Helper of Tim protein 13; Zinc-binding mitochondrial intermembrane space (IMS) protein; involved in a disulfide relay system for IMS import of cysteine-containing proteins; binds Mia40p and stimulates its Erv1p-dependent oxidation, probably by sequestering zinc.


ensembl_gene_id: YKL085W
symbol: MDH1
gene_biotype: protein_coding
description:
  Mitochondrial malate dehydrogenase; catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated; Belongs to the LDH/MDH superfamily. MDH type 1 family.


ensembl_gene_id: YKL086W
symbol: SRX1
gene_biotype: protein_coding
description:
  Sulfiredoxin; contributes to oxidative stress resistance by reducing cysteine-sulfinic acid groups in the peroxiredoxin Tsa1p, which is formed upon exposure to oxidants; conserved in higher eukaryotes; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YKL087C
symbol: CYT2
gene_biotype: protein_coding
description:
  Cytochrome c1 heme lyase; involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1; human homolog HCCS can complement yeast cyt2 null mutant.


ensembl_gene_id: YKL088W
symbol: CAB3
gene_biotype: protein_coding
description:
  Coenzyme A biosynthesis protein 3; Subunit of PPCDC and CoA-SPC complexes involved in CoA biosynthesis; subunits of the phosphopantothenoylcysteine decarboxylase (PPCDC) complex are: Cab3p, Sis2p, Vhs3p, while the subunits of the CoA-synthesizing protein complex (CoA-SPC) are: Cab2p, Cab3p, Cab4p, and Cab5p as well as Sis2p and Vhs3p; null mutant lethality is complemented by E. coli coaBC.


ensembl_gene_id: YKL089W
symbol: MIF2
gene_biotype: protein_coding
description:
  Inner kinetochore subunit MIF2; Protein required for structural integrity of elongating spindles; localizes to the kinetochore; interacts with histones H2A, H2B, and H4; phosphorylated by Ipl1p; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-C and fission yeast cnp3; Belongs to the CENP-C/MIF2 family.


ensembl_gene_id: YKL090W
symbol: CUE2
gene_biotype: protein_coding
description:
  Ubiquitin-binding protein CUE2; Protein of unknown function; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination.


ensembl_gene_id: YKL091C
symbol: YKL091C
gene_biotype: protein_coding
description:
  CRAL-TRIO domain-containing protein YKL091C; Putative phosphatidylinositol/phosphatidylcholine transfer protein; possibly involved in lipid metabolism; localizes to the nucleus; contains a CRAL/TRIO domain and binds several lipids in a large-scale study; YKL091C has a paralog, SEC14, that arose from the whole genome duplication.


ensembl_gene_id: YKL092C
symbol: BUD2
gene_biotype: protein_coding
description:
  Inhibitory regulator protein BUD2/CLA2; GTPase activating factor for Rsr1p/Bud1p; plays a role in spindle position checkpoint distinct from its role in bud site selection; required for both axial and bipolar budding patterns; mutants exhibit random budding in all cell types; contains two PH-like domains.


ensembl_gene_id: YKL093W
symbol: MBR1
gene_biotype: protein_coding
description:
  Mitochondrial biogenesis regulation protein 1; Protein involved in mitochondrial functions and stress response; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; MBR1 has a paralog, ISF1, that arose from the whole genome duplication.


ensembl_gene_id: YKL094W
symbol: YJU3
gene_biotype: protein_coding
description:
  Monoglyceride lipase (MGL); functional ortholog of mammalian MGL, localizes to lipid particles and membranes, also member of the eukaryotic serine hydrolase family; Belongs to the AB hydrolase superfamily. Monoacylglycerol lipase family.


ensembl_gene_id: YKL095W
symbol: YJU2
gene_biotype: protein_coding
description:
  Splicing factor YJU2; Essential protein required for pre-mRNA splicing; associates transiently with the spliceosomal NTC (nineteen complex) and acts after Prp2p to promote the first catalytic reaction of splicing.


ensembl_gene_id: YKL096C-B
symbol: YKL096C-B
gene_biotype: protein_coding
description:
  Uncharacterized protein YKL096C-B; Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching.


ensembl_gene_id: YKL096W
symbol: CWP1
gene_biotype: protein_coding
description:
  Cell wall mannoprotein that localizes to birth scars of daughter cells; linked to a beta-1,3- and beta-1,6-glucan heteropolymer through a phosphodiester bond; required for propionic acid resistance; Belongs to the SRP1/TIP1 family.


ensembl_gene_id: YKL096W-A
symbol: CWP2
gene_biotype: protein_coding
description:
  Covalently linked cell wall mannoprotein; major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored.


ensembl_gene_id: YKL097C
symbol: YKL097C
gene_biotype: protein_coding
description:
  Uncharacterized protein YKL097C; Putative protein of unknown function; conserved across S. cerevisiae strains; not conserved in closely related Saccharomyces species.


ensembl_gene_id: YKL099C
symbol: UTP11
gene_biotype: protein_coding
description:
  U3 small nucleolar RNA-associated protein 11; Subunit of U3-containing Small Subunit (SSU) processome complex; involved in production of 18S rRNA and assembly of small ribosomal subunit.


ensembl_gene_id: YKL100C
symbol: YPF1
gene_biotype: protein_coding
description:
  Intramembrane aspartyl protease of the perinuclear ER membrane; acts in a branch of ER-associated degradation (ERAD) that degrades functional proteins rather than misfolded proteins; regulates abundance of high-affinity plasma membrane transporters, such as Ctr1p and Zrt1p, during the starvation response; has a presenilin fold; member of the GxGD family of intramembrane proteases; closest human homolog is signal peptide peptidase (SPP).


ensembl_gene_id: YKL100W-A
symbol: YKL100W-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YKL100W-A; Putative protein of unknown function; identified by expression profiling and mass spectrometry.


ensembl_gene_id: YKL101W
symbol: HSL1
gene_biotype: protein_coding
description:
  Probable serine/threonine-protein kinase HSL1; Nim1p-related protein kinase; septin-binding kinase that localizes to the bud neck septin ring and regulates the morphogenesis checkpoint; phosphorylates Hsl7p and cooperates with Elm1p to recruit Hsl7p to the mother-bud neck, as a prerequisite for the subsequent recruitment, phosphorylation, and degradation of Swe1p; autophosphorylation enhances interactions with Hsl7p.


ensembl_gene_id: YKL102C
symbol: YKL102C
gene_biotype: protein_coding
description:
  Uncharacterized protein YKL102C; Putative protein of unknown function; conserved across S. cerevisiae strains; deletion confers sensitivity to citric acid; predicted protein would include a thiol-disulfide oxidoreductase active site.


ensembl_gene_id: YKL103C
symbol: APE1
gene_biotype: protein_coding
description:
  Vacuolar aminopeptidase yscI; zinc metalloproteinase that belongs to the peptidase family M18; often used as a marker protein in studies of autophagy and cytosol to vacuole targeting (CVT) pathway; protein increases in abundance and relative distribution to cytoplasmic foci increases upon DNA replication stress.


ensembl_gene_id: YKL104C
symbol: GFA1
gene_biotype: protein_coding
description:
  Glutamine--fructose-6-phosphate aminotransferase [isomerizing]; Glutamine-fructose-6-phosphate amidotransferase; catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis; GFA1 has a paralogous region, comprising ORFs YMR084W-YMR085W, that arose from the whole genome duplication.


ensembl_gene_id: YKL105C
symbol: SEG2
gene_biotype: protein_coding
description:
  Eisosome protein SEG2; Eisosome component; likely plays only a minor role in eisosome assembly; shown to interact with Seg1p by affinity purification and mass spec; SWAT-GFP and mCherry fusion proteins localize to the cell periphery; similar to <i>A. gossypii</i> SEG gene which is important for stabilizing eisosomes; SEG2 has a paralog, SEG1, that arose from the whole genome duplication.


ensembl_gene_id: YKL106C-A
symbol: YKL106C-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YKL106C-A; Putative protein of unknown function; identified by homology to uncharacterized proteins in other fungi.


ensembl_gene_id: YKL106W
symbol: AAT1
gene_biotype: protein_coding
description:
  Mitochondrial aspartate aminotransferase; catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis.


ensembl_gene_id: YKL107W
symbol: YKL107W
gene_biotype: protein_coding
description:
  Uncharacterized oxidoreductase YKL107W; Putative short-chain dehydrogenase/reductase; proposed to be a palmitoylated membrane protein.


ensembl_gene_id: YKL108W
symbol: SLD2
gene_biotype: protein_coding
description:
  DNA replication regulator SLD2; Single-stranded DNA origin-binding and annealing protein; required for initiation of DNA replication; phosphorylated in S phase by cyclin-dependent kinases (Cdks), promoting origin binding, DNA replication and Dpb11p complex formation; component of the preloading complex; binds the Mcm2-7p complex to prevent inappropriate Mcm2-7p interaction with the GINS complex in G1; required for S phase checkpoint; relative distribution to the nucleus increases upon DNA replication stress; Belongs to the SLD2 family.


ensembl_gene_id: YKL109W
symbol: HAP4
gene_biotype: protein_coding
description:
  Transcriptional activator HAP4; Transcription factor; subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex; involved in diauxic shift.


ensembl_gene_id: YKL110C
symbol: KTI12
gene_biotype: protein_coding
description:
  Protein that plays a role in modification of tRNA wobble nucleosides; protein plays role in tRNA wobble nucleoside modification with Elongator complex; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p; Belongs to the KTI12 family.


ensembl_gene_id: YKL111C
symbol: YKL111C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YKL111C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; partially overlaps the verified essential gene ABF1.


ensembl_gene_id: YKL112W
symbol: ABF1
gene_biotype: protein_coding
description:
  ARS-binding factor 1; DNA binding protein with possible chromatin-reorganizing activity; involved in transcriptional activation, gene silencing, and DNA replication and repair; Belongs to the BAF1 family.


ensembl_gene_id: YKL113C
symbol: RAD27
gene_biotype: protein_coding
description:
  Flap endonuclease 1; 5' to 3' exonuclease, 5' flap endonuclease; required for Okazaki fragment processing and maturation, for long-patch base-excision repair and large loop repair (LLR), ribonucleotide excision repair; member of the S. pombe RAD2/FEN1 family; relocalizes to the cytosol in response to hypoxia.


ensembl_gene_id: YKL114C
symbol: APN1
gene_biotype: protein_coding
description:
  DNA-(apurinic or apyrimidinic site) lyase 1; Major apurinic/apyrimidinic endonuclease; 3'-repair diesterase; involved in repair of DNA damage by oxidation and alkylating agents; also functions as a 3'-5' exonuclease to repair 7,8-dihydro-8-oxodeoxyguanosine; genetically interacts with NTG1 to maintain mitochondrial genome integrity; Belongs to the AP endonuclease 2 family.


ensembl_gene_id: YKL115C
symbol: YKL115C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YKL115C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PRR1.


ensembl_gene_id: YKL116C
symbol: PRR1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase PRR1; Serine/threonine protein kinase; inhibits pheromone induced signaling downstream of MAPK, possibly at the level of the Ste12p transcription factor.


ensembl_gene_id: YKL117W
symbol: SBA1
gene_biotype: protein_coding
description:
  Co-chaperone protein SBA1; Co-chaperone that binds and regulates Hsp90 family chaperones; plays a role in determining prion variants; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins, and like p23 can regulate telomerase activity; protein abundance increases in response to DNA replication stress; Belongs to the p23/wos2 family.


ensembl_gene_id: YKL118W
symbol: YKL118W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YKL118W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPH2.


ensembl_gene_id: YKL119C
symbol: VPH2
gene_biotype: protein_coding
description:
  Integral membrane protein required for V-ATPase function; not an actual component of the vacuolar H+-ATPase (V-ATPase) complex; functions in the assembly of the V-ATPase; localized to the endoplasmic reticulum (ER); involved in methionine restriction extension of chronological lifespan in an autophagy-dependent manner.


ensembl_gene_id: YKL120W
symbol: OAC1
gene_biotype: protein_coding
description:
  Mitochondrial inner membrane transporter; transports oxaloacetate, sulfate, thiosulfate, and isopropylmalate; member of the mitochondrial carrier family.


ensembl_gene_id: YKL121W
symbol: DGR2
gene_biotype: protein_coding
description:
  Protein of unknown function; null mutant is resistant to 2-deoxy-D-glucose and displays abnormally elongated buds; DGR2 has a paralog, YMR102C, that arose from the whole genome duplication; Belongs to the WD repeat DGR2 family.


ensembl_gene_id: YKL122C
symbol: SRP21
gene_biotype: protein_coding
description:
  Subunit of the signal recognition particle (SRP); SRP functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm.


ensembl_gene_id: YKL123W
symbol: YKL123W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YKL123W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SSH4.


ensembl_gene_id: YKL124W
symbol: SSH4
gene_biotype: protein_coding
description:
  Protein SSH4; Specificity factor required for Rsp5p-dependent ubiquitination; also required for sorting of cargo proteins at the multivesicular body; identified as a high-copy suppressor of a SHR3 deletion, increasing steady-state levels of amino acid permeases.


ensembl_gene_id: YKL125W
symbol: RRN3
gene_biotype: protein_coding
description:
  Protein required for transcription of rDNA by RNA polymerase I; transcription factor independent of DNA template; involved in recruitment of RNA polymerase I to rDNA; structure reveals unique HEAT repeat fold and a surface serine patch; phosphorylation of serine patch impairs cell growth and reduces RNA polymerase I binding in vitro and RNA polymerase I recruitment to the rDNA gene in vivo; Belongs to the RRN3 family.


ensembl_gene_id: YKL126W
symbol: YPK1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase YPK1; S/T protein kinase; phosphorylates, downregulates flippase activator Fpk1p; inactivates Orm1p and Orm2p by phosphorylation in response to compromised sphingolipid synthesis; involved in the TORC-dependent phosphorylation of ribosomal proteins Rps6a/b (S6); mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways; human homolog SGK1 can complement a null mutant; human homolog SGK2 can complement a ypk1 ypk2 double mutant; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase famil [...]


ensembl_gene_id: YKL127W
symbol: PGM1
gene_biotype: protein_coding
description:
  Phosphoglucomutase, minor isoform; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; PGM1 has a paralog, PGM2, that arose from the whole genome duplication.


ensembl_gene_id: YKL128C
symbol: PMU1
gene_biotype: protein_coding
description:
  Probable phosphoglycerate mutase PMU1; Putative phosphomutase; contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant.


ensembl_gene_id: YKL129C
symbol: MYO3
gene_biotype: protein_coding
description:
  Myosin-3; One of two type I myosins; localizes to actin cortical patches; deletion of MYO3 has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization; MYO3 has a paralog, MYO5, that arose from the whole genome duplication; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.


ensembl_gene_id: YKL130C
symbol: SHE2
gene_biotype: protein_coding
description:
  SWI5-dependent HO expression protein 2; RNA-binding protein that binds specific mRNAs and interacts with She3p; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud; binds to ER-derived membranes and targets mRNAs to cortical ER.


ensembl_gene_id: YKL131W
symbol: YKL131W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YKL131W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YKL132C
symbol: RMA1
gene_biotype: protein_coding
description:
  Probable folylpolyglutamate synthase; Putative dihydrofolate synthetase; similar to E. coli folylpolyglutamate synthetase/dihydrofolate synthetase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; RMA1 has a paralog, FOL3, that arose from the whole genome duplication.


ensembl_gene_id: YKL133C
symbol: YKL133C
gene_biotype: protein_coding
description:
  Putative protein of unknown function; not required for growth of cells lacking the mitochondrial genome; SWAT-GFP and mCherry fusion proteins localize to the mitochondria; YKL133C has a paralog, MGR3, that arose from the whole genome duplication.


ensembl_gene_id: YKL134C
symbol: OCT1
gene_biotype: protein_coding
description:
  Mitochondrial intermediate peptidase; cleaves destabilizing N-terminal residues of a subset of proteins upon import, after their cleavage by mitochondrial processing peptidase (Mas1p-Mas2p); may contribute to mitochondrial iron homeostasis.


ensembl_gene_id: YKL135C
symbol: APL2
gene_biotype: protein_coding
description:
  AP-1 complex subunit beta-1; Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YKL136W
symbol: YKL136W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YKL136W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF APL2/YKL135C.


ensembl_gene_id: YKL137W
symbol: CMC1
gene_biotype: protein_coding
description:
  Copper-binding protein of the mitochondrial intermembrane space; evolutionarily conserved; may be involved in delivering copper from the matrix to the cytochrome c oxidase complex; contains a twin CX9C motif.


ensembl_gene_id: YKL139W
symbol: CTK1
gene_biotype: protein_coding
description:
  Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I); phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity; required for H3K36 trimethylation but not dimethylation by Set2p; suggested stimulatory role in 80S formation during translation initiation; similar to the Drosophila dCDK12 and human CDK12 and probably CDK13; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.


ensembl_gene_id: YKL140W
symbol: TGL1
gene_biotype: protein_coding
description:
  Sterol esterase TGL1; Steryl ester hydrolase; one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes.


ensembl_gene_id: YKL141W
symbol: SDH3
gene_biotype: protein_coding
description:
  Subunit of succinate dehydrogenase and of TIM22 translocase; functions as cytochrome b subunit of succinate dehydrogenase, which couples oxidation of succinate to transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; also required for mitochondrial inner membrane protein import as part of the TIM22 complex; SDH3 has a paralog, SHH3, that arose from the whole genome duplication.


ensembl_gene_id: YKL142W
symbol: MRP8
gene_biotype: protein_coding
description:
  Uncharacterized protein MRP8; Protein of unknown function; undergoes sumoylation; transcription induced under cell wall stress; protein levels are reduced under anaerobic conditions; protein abundance increases in response to DNA replication stress; originally thought to be a mitochondrial ribosomal protein based on sequence analysis.


ensembl_gene_id: YKL143W
symbol: LTV1
gene_biotype: protein_coding
description:
  Protein LTV1; Component of the GSE complex; GSE is required for proper sorting of amino acid permease Gap1p; required for ribosomal small subunit export from nucleus; required for growth at low temperature; Belongs to the LTV1 family.


ensembl_gene_id: YKL144C
symbol: RPC25
gene_biotype: protein_coding
description:
  RNA polymerase III subunit C25; required for transcription initiation; forms a heterodimer with Rpc17p; paralog of Rpb7p.


ensembl_gene_id: YKL145W
symbol: RPT1
gene_biotype: protein_coding
description:
  ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; required for optimal CDC20 transcription; interacts with Rpn12p and Ubr1p; mutant has aneuploidy tolerance.


ensembl_gene_id: YKL145W-A
symbol: YKL145W-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YKL145W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified essential gene RPT1; identified by expression profiling and mass spectrometry.


ensembl_gene_id: YKL146W
symbol: AVT3
gene_biotype: protein_coding
description:
  Vacuolar transporter; exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters.


ensembl_gene_id: YKL147C
symbol: YKL147C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YKL147C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; partially overlaps the verified gene AVT3.


ensembl_gene_id: YKL148C
symbol: SDH1
gene_biotype: protein_coding
description:
  Flavoprotein subunit of succinate dehydrogenase; couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; FAD binding to Sdh1p is required for the assembly of the succinate dehydrogenase subunits; mutations in human ortholog SDHA are associated with Leigh syndrome.


ensembl_gene_id: YKL149C
symbol: DBR1
gene_biotype: protein_coding
description:
  RNA lariat debranching enzyme; catalyzes debranching of lariat introns formed during pre-mRNA splicing; required for efficient Ty1 transposition; knockdown of human homolog Dbr1 rescues toxicity of RNA-binding proteins TDP-43 and FUS which are implicated in amyotrophic lateral sclerosis (ALS), suggests potential therapeutic target for ALS and related TDP-43 proteinopathies; human homolog DBR1 can complement yeast dbr1 null mutant.


ensembl_gene_id: YKL150W
symbol: MCR1
gene_biotype: protein_coding
description:
  Mitochondrial NADH-cytochrome b5 reductase; involved in ergosterol biosynthesis; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.


ensembl_gene_id: YKL151C
symbol: NNR2
gene_biotype: protein_coding
description:
  Widely-conserved NADHX dehydratase; converts (S)-NADHX to NADH in ATP-dependent manner; YKL151C promoter contains STREs (stress response elements) and expression is induced by heat shock or methyl methanesulfonate; downstream intergenic region drives antisense expression and mediates coordinated regulation of YKL151C and GPM1 phosphoglycerate mutase; protein abundance increases in response to DNA replication stress; homolog of Carkd in mammals and C-terminus of YjeF in E.coli; Belongs to the NnrD/CARKD family.


ensembl_gene_id: YKL152C
symbol: GPM1
gene_biotype: protein_coding
description:
  Tetrameric phosphoglycerate mutase; mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily.


ensembl_gene_id: YKL153W
symbol: YKL153W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YKL153W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; transcription of both YLK153W and the overlapping essential gene GPM1 is reduced in the gcr1 null mutant.


ensembl_gene_id: YKL154W
symbol: SRP102
gene_biotype: protein_coding
description:
  Signal recognition particle (SRP) receptor beta subunit; involved in SRP-dependent protein targeting; anchors the alpha subunit, Srp101p to the ER membrane.


ensembl_gene_id: YKL155C
symbol: RSM22
gene_biotype: protein_coding
description:
  Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent RNA methyltransferase.


ensembl_gene_id: YKL156C-A
symbol: YKL156C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YKL156C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified gene RPS27A; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching.


ensembl_gene_id: YKL156W
symbol: RPS27A
gene_biotype: protein_coding
description:
  Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S27, no bacterial homolog; RPS27A has a paralog, RPS27B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YKL157W
symbol: APE2
gene_biotype: protein_coding
description:
  Aminopeptidase 2, mitochondrial; Aminopeptidase yscII; may have a role in obtaining leucine from dipeptide substrates; APE2 has a paralog, AAP1, that arose from the whole genome duplication; Belongs to the peptidase M1 family.


ensembl_gene_id: YKL159C
symbol: RCN1
gene_biotype: protein_coding
description:
  Protein involved in calcineurin regulation during calcium signaling; has similarity to H. sapiens DSCR1 which is found in the Down Syndrome candidate region.


ensembl_gene_id: YKL160W
symbol: ELF1
gene_biotype: protein_coding
description:
  Transcription elongation factor with a conserved zinc finger domain; implicated in the maintenance of proper chromatin structure in actively transcribed regions; deletion inhibits Brome mosaic virus (BMV) gene expression.


ensembl_gene_id: YKL161C
symbol: KDX1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase KDX1; Protein kinase; implicated in Slt2p mitogen-activated (MAP) kinase signaling pathway; interacts with numerous components in the mating pheromone and CWI MAPK pathways; associates with Rlm1p; KDX1 has a paralog, SLT2, that arose from the whole genome duplication.


ensembl_gene_id: YKL162C
symbol: YKL162C
gene_biotype: protein_coding
description:
  Protein arginine methyltransferase NDUFAF7 homolog, mitochondrial; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; Belongs to the NDUFAF7 family.


ensembl_gene_id: YKL162C-A
symbol: YKL162C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YKL162C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YKL163W
symbol: PIR3
gene_biotype: protein_coding
description:
  O-glycosylated covalently-bound cell wall protein; required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway; coding sequence contains length polymorphisms in different strains; PIR3 has a paralog, HSP150, that arose from the whole genome duplication.


ensembl_gene_id: YKL164C
symbol: PIR1
gene_biotype: protein_coding
description:
  O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle; PIR1 has a paralog, YJL160C, that arose from the whole genome duplication.


ensembl_gene_id: YKL165C
symbol: MCD4
gene_biotype: protein_coding
description:
  GPI ethanolamine phosphate transferase 1; Protein involved in GPI anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes; GPI stands for glycosylphosphatidylinositol.


ensembl_gene_id: YKL165C-A
symbol: YKL165C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized YKL165C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YKL166C
symbol: TPK3
gene_biotype: protein_coding
description:
  cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase; TPK3 has a paralog, TPK1, that arose from the whole genome duplication.


ensembl_gene_id: YKL168C
symbol: KKQ8
gene_biotype: protein_coding
description:
  Putative serine/threonine protein kinase with unknown cellular role; KKQ8 has a paralog, HAL5, that arose from the whole genome duplication; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NPR/HAL subfamily. HAL5 sub-subfamily.


ensembl_gene_id: YKL169C
symbol: YKL169C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YKL169C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MRPL38.


ensembl_gene_id: YKL170W
symbol: MRPL38
gene_biotype: protein_coding
description:
  Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YKL171W
symbol: NNK1
gene_biotype: protein_coding
description:
  Nitrogen network kinase 1; Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm.


ensembl_gene_id: YKL172W
symbol: EBP2
gene_biotype: protein_coding
description:
  rRNA-processing protein EBP2; Required for 25S rRNA maturation and 60S ribosomal subunit assembly; localizes to the nucleolus and in foci along nuclear periphery; constituent of 66S pre-ribosomal particles; cooperates with Rrs1p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering.


ensembl_gene_id: YKL173W
symbol: SNU114
gene_biotype: protein_coding
description:
  Pre-mRNA-splicing factor SNU114; GTPase component of U5 snRNP involved in mRNA splicing via spliceosome; binds directly to U5 snRNA; proposed to be involved in conformational changes of the spliceosome; similarity to ribosomal translocation factor EF-2.


ensembl_gene_id: YKL174C
symbol: TPO5
gene_biotype: protein_coding
description:
  Polyamine transporter TPO5; Protein involved in excretion of putrescine and spermidine; putative polyamine transporter in the Golgi or post-Golgi vesicles; Belongs to the amino acid-polyamine-organocation (APC) superfamily.


ensembl_gene_id: YKL175W
symbol: ZRT3
gene_biotype: protein_coding
description:
  Zinc-regulated transporter 3; Vacuolar membrane zinc transporter; transports zinc from storage in the vacuole to the cytoplasm when needed; transcription is induced under conditions of zinc deficiency; Belongs to the ZIP transporter (TC 2.A.5) family.


ensembl_gene_id: YKL176C
symbol: LST4
gene_biotype: protein_coding
description:
  Subunit of the Lst4p-Lst7p GTPase activating protein complex for Gtr2p; stimulates the GTPase activity of Rag family GTPase Gtr2p, within the context of the Gtr1p-Gtr2p heterodimer, after amino acid stimulation; required for activation of TORC1 in response to amino acid stimulation; recruited to the vacuolar membrane during amino acid starvation and released from the membrane by TORC1; required for the transport of amino acid permease Gap1p from the Golgi to the cell surface.


ensembl_gene_id: YKL177W
symbol: YKL177W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YKL177W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene STE3.


ensembl_gene_id: YKL178C
symbol: STE3
gene_biotype: protein_coding
description:
  Receptor for a factor pheromone; couples to MAP kinase cascade to mediate pheromone response; transcribed in alpha cells and required for mating by alpha cells, ligand bound receptors endocytosed and recycled to the plasma membrane; GPCR.


ensembl_gene_id: YKL179C
symbol: COY1
gene_biotype: protein_coding
description:
  Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function.


ensembl_gene_id: YKL180W
symbol: RPL17A
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L17A; required for processing of 27SB pre-rRNA and formation of stable 66S assembly intermediates; copurifies with the Dam1 complex (aka DASH complex); homologous to mammalian ribosomal protein L17 and bacterial L22; RPL17A has a paralog, RPL17B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YKL181W
symbol: PRS1
gene_biotype: protein_coding
description:
  Ribose-phosphate pyrophosphokinase 1; 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; plays a key role in cell wall integrity (CWI) pathway; one of five related enzymes, which are active as heteromultimeric complexes; missense mutations in human homolog PRPS1 are associated with neuropathic Arts syndrome and Charcot-Marie Tooth (CMTX5) disease; Belongs to the ribose-phosphate pyrophosphokinase family.


ensembl_gene_id: YKL182W
symbol: FAS1
gene_biotype: protein_coding
description:
  3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Beta subunit of fatty acid synthetase; complex catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities.


ensembl_gene_id: YKL183C-A
symbol: YKL183C-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YKL183C-A; Putative protein of unknown function; identified by fungal homology and RT-PCR.


ensembl_gene_id: YKL183W
symbol: LOT5
gene_biotype: protein_coding
description:
  Protein of unknown function; gene expression increases in cultures shifted to a lower temperature; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YKL184W
symbol: SPE1
gene_biotype: protein_coding
description:
  Ornithine decarboxylase; catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines; deletion decreases lifespan, and increases necrotic cell death and ROS generation; Belongs to the Orn/Lys/Arg decarboxylase class-II family.


ensembl_gene_id: YKL185W
symbol: ASH1
gene_biotype: protein_coding
description:
  Transcriptional regulatory protein ASH1; Component of the Rpd3L histone deacetylase complex; zinc-finger inhibitor of HO transcription; mRNA is localized and translated in the distal tip of anaphase cells, resulting in accumulation of Ash1p in daughter cell nuclei and inhibition of HO expression; potential Cdc28p substrate.


ensembl_gene_id: YKL186C
symbol: MTR2
gene_biotype: protein_coding
description:
  mRNA transport regulator; essential nuclear protein; Mex67p and Mtr2p form a mRNA export complex which binds to RNA.


ensembl_gene_id: YKL187C
symbol: FAT3
gene_biotype: protein_coding
description:
  Uncharacterized protein YKL187C; Protein required for fatty acid uptake; protein abundance increases in cortical patches in response to oleate exposure; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; FAT3 has a paralog, YLR413W, that arose from the whole genome duplication.


ensembl_gene_id: YKL188C
symbol: PXA2
gene_biotype: protein_coding
description:
  Peroxisomal long-chain fatty acid import protein 1; Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa1p; required for import of long-chain fatty acids into peroxisomes; similar to human adrenoleukodystrophy transportesr ABCD1 and ABCD2, and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder; human ABCD1 and ABCD2 can each partially complement yeast pxa1 pxa2 double null mutant; Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.


ensembl_gene_id: YKL189W
symbol: HYM1
gene_biotype: protein_coding
description:
  Protein HYM1; Component of the RAM signaling network; is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with Kic1p and Sog2p, localizes to sites of polarized growth during budding and during the mating response; Belongs to the Mo25 family.


ensembl_gene_id: YKL190W
symbol: CNB1
gene_biotype: protein_coding
description:
  Calcineurin B; regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (stress-response transcription factor); other calcineurin subunit encoded by CNA1 and/or CMP1; regulates function of Aly1p alpha-arrestin; myristoylation by Nmt1p reduces calcineurin activity in response to submaximal Ca signals, is needed to prevent constitutive phosphatase activity; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YKL191W
symbol: DPH2
gene_biotype: protein_coding
description:
  2-(3-amino-3-carboxypropyl)histidine synthase subunit 2; Protein required for synthesis of diphthamide; required along with Dph1p, Kti11p, Jjj3p, and Dph5p; diphthamide is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph1p and Kti11p.


ensembl_gene_id: YKL192C
symbol: ACP1
gene_biotype: protein_coding
description:
  Mitochondrial matrix acyl carrier protein; involved in biosynthesis of octanoate, which is a precursor to lipoic acid; activated by phosphopantetheinylation catalyzed by Ppt2p.


ensembl_gene_id: YKL193C
symbol: SDS22
gene_biotype: protein_coding
description:
  Regulatory subunit of the type 1 protein phosphatase (PP1) Glc7p; whether it functions as a positive or negative regulator of Glc7p is controversial; involved in the regulation of Glc7p nuclear localization and function.


ensembl_gene_id: YKL194C
symbol: MST1
gene_biotype: protein_coding
description:
  Threonine--tRNA ligase, mitochondrial; Mitochondrial threonyl-tRNA synthetase; aminoacylates both the canonical threonine tRNA tT(UGU)Q1 and the unusual threonine tRNA tT(UAG)Q2 in vitro; lacks a typical editing domain, but has pre-transfer editing activity stimulated by the unusual tRNA-Thr.


ensembl_gene_id: YKL195W
symbol: MIA40
gene_biotype: protein_coding
description:
  Import and assembly protein in mitochondrial intermembrane space; component of MIA pathway which mediates import and oxidative folding of substrates including small proteins containing twin cysteine motifs; acts in concert with Erv1p, which oxidizes the cysteine residues of Mia40p to comprise a disulfide relay system that catalyzes import; also mediates folding of Atp23p via a chaperone-like activity; forms a dimer that binds iron-sulfur cluster in vitro.


ensembl_gene_id: YKL196C
symbol: YKT6
gene_biotype: protein_coding
description:
  Synaptobrevin homolog YKT6; Vesicle membrane protein (v-SNARE) with acyltransferase activity; involved in trafficking to and within the Golgi, endocytic trafficking to the vacuole, and vacuolar fusion; membrane localization due to prenylation at the carboxy-terminus; human homolog YKT6 can complement yeast ykt6 mutant; Belongs to the synaptobrevin family.


ensembl_gene_id: YKL197C
symbol: PEX1
gene_biotype: protein_coding
description:
  Peroxisomal ATPase PEX1; AAA-peroxin; heterodimerizes with AAA-peroxin Pex6p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol; induced by oleic acid and upregulated during anaerobiosis; mutations in human PEX1 can lead to severe peroxisomal disorders and early death.


ensembl_gene_id: YKL198C
symbol: PTK1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase PTK1/STK1; Putative serine/threonine protein kinase; regulates spermine uptake; involved in polyamine transport; possible mitochondrial protein; PTK1 has a paralog, PTK2, that arose from the whole genome duplication.


ensembl_gene_id: YKL201C
symbol: MNN4
gene_biotype: protein_coding
description:
  Protein MNN4; Putative positive regulator of mannosylphosphate transferase Mnn6p; involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases; coding sequence contains length polymorphisms in different strains; MNN4 has a paralog, YJR061W, that arose from the whole genome duplication; To yeast YJR061w.


ensembl_gene_id: YKL202W
symbol: YKL202W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YKL202W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YKL203C
symbol: TOR2
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase TOR2; PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication.


ensembl_gene_id: YKL204W
symbol: EAP1
gene_biotype: protein_coding
description:
  eIF4E-associated protein, competes with eIF4G for binding to eIF4E; accelerates mRNA degradation by promoting decapping, facilitated by interaction with eIF4E; essential for Puf5p mediated repression; associates with Puf5p and Dhh1p; inhibits cap-dependent translation; functions independently of eIF4E to maintain genetic stability; plays a role in cell growth, implicated in the TOR signaling cascade.


ensembl_gene_id: YKL205W
symbol: LOS1
gene_biotype: protein_coding
description:
  Exportin-T; Nuclear pore protein; involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm; deletion mutation extends replicative lifespan, as does exclusion of Los1p from the nucleus in response to caloric restriction; Belongs to the exportin family.


ensembl_gene_id: YKL206C
symbol: ADD66
gene_biotype: protein_coding
description:
  Protein involved in 20S proteasome assembly; forms a heterodimer with Pba1p that binds to proteasome precursors; interaction with Pba1p-Add66p may affect function of the mature proteasome and its role in maintaining respiratory metabolism; similar to human PAC2 constituent of the PAC1-PAC2 complex involved in proteasome assembly.


ensembl_gene_id: YKL207W
symbol: EMC3
gene_biotype: protein_coding
description:
  Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; required for respiratory growth; null mutant displays induction of the unfolded protein response; homologous to worm Y62E10A.10/EMC-3, fly CG6750, human TMEM111.


ensembl_gene_id: YKL208W
symbol: CBT1
gene_biotype: protein_coding
description:
  Cytochrome b termination protein 1; Protein involved in 5' RNA end processing; substrates include mitochondrial COB, 15S_rRNA, and RPM1 transcripts; may also have a role in 3' end processing of the COB pre-mRNA; displays genetic interaction with cell cycle-regulated kinase Dbf2p.


ensembl_gene_id: YKL209C
symbol: STE6
gene_biotype: protein_coding
description:
  Alpha-factor-transporting ATPase; Plasma membrane ATP-binding cassette (ABC) transporter; required for the export of a-factor, catalyzes ATP hydrolysis coupled to a-factor transport; contains 12 transmembrane domains and two ATP binding domains; expressed only in MATa cells; human homolog ABCB1 mediates multidrug resistance in many chemotherapy-resistant tumors by effluxing toxic compounds from the cell.


ensembl_gene_id: YKL210W
symbol: UBA1
gene_biotype: protein_coding
description:
  Ubiquitin activating enzyme (E1); involved in ubiquitin-mediated protein degradation and essential for viability; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YKL211C
symbol: TRP3
gene_biotype: protein_coding
description:
  Multifunctional tryptophan biosynthesis protein; Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p.


ensembl_gene_id: YKL212W
symbol: SAC1
gene_biotype: protein_coding
description:
  Phosphoinositide phosphatase SAC1; Phosphatidylinositol phosphate (PtdInsP) phosphatase; involved in hydrolysis of PtdIns[4]P in the early and medial Golgi; regulated by interaction with Vps74p; ER localized transmembrane protein which cycles through the Golgi; involved in protein trafficking and processing, secretion, and cell wall maintenance; regulates sphingolipid biosynthesis through the modulation of PtdIns(4)P metabolism.


ensembl_gene_id: YKL213C
symbol: DOA1
gene_biotype: protein_coding
description:
  WD repeat protein required for ubiquitin-mediated protein degradation; ubiquitin binding cofactor that complexes with Cdc48p; required for ribophagy; controls cellular ubiquitin concentration; promotes efficient NHEJ in postdiauxic/stationary phase; facilitates N-terminus-dependent proteolysis of centromeric histone H3 (Cse4p) for faithful chromosome segregation; protein increases in abundance and relocalizes from nucleus to nuclear periphery upon DNA replication stress.


ensembl_gene_id: YKL214C
symbol: YRA2
gene_biotype: protein_coding
description:
  RNA annealing protein YRA2; Member of the REF (RNA and export factor binding proteins) family; when overexpressed, can substitute for the function of Yra1p in export of poly(A)+ mRNA from the nucleus.


ensembl_gene_id: YKL215C
symbol: OXP1
gene_biotype: protein_coding
description:
  5-oxoprolinase; enzyme is ATP-dependent and functions as a dimer; similar to mouse Oplah gene; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YKL216W
symbol: URA1
gene_biotype: protein_coding
description:
  Dihydroorotate dehydrogenase; catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acid.


ensembl_gene_id: YKL217W
symbol: JEN1
gene_biotype: protein_coding
description:
  Carboxylic acid transporter protein homolog; Monocarboxylate/proton symporter of the plasma membrane; transport activity is dependent on the pH gradient across the membrane; mediates high-affinity uptake of carbon sources lactate, pyuvate, and acetate, and also of the micronutrient selenite, whose structure mimics that of monocarboxylates; expression and localization are tightly regulated, with transcription repression, mRNA degradation, and protein endocytosis and degradation all occurring in the presence of glucose; Belongs to the major facilitator superfamily. Sugar transporter (TC  [...]


ensembl_gene_id: YKL218C
symbol: SRY1
gene_biotype: protein_coding
description:
  3-hydroxyaspartate dehydratase; deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required in the presence of hydroxyaspartate; highly similar to mouse serine racemase (Srr) but has no serine racemase activity.


ensembl_gene_id: YKL220C
symbol: FRE2
gene_biotype: protein_coding
description:
  Ferric/cupric reductase transmembrane component 2; Ferric reductase and cupric reductase; reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels; Belongs to the ferric reductase (FRE) family.


ensembl_gene_id: YKL221W
symbol: MCH2
gene_biotype: protein_coding
description:
  Probable transporter MCH2; Protein with similarity to mammalian monocarboxylate permeases; monocarboxylate permeases are involved in transport of monocarboxylic acids across the plasma membrane but mutant is not deficient in monocarboxylate transport; Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.


ensembl_gene_id: YKL222C
symbol: YKL222C
gene_biotype: protein_coding
description:
  Uncharacterized transcriptional regulatory protein YKL222C; Protein of unknown function; may interact with ribosomes, based on co-purification experiments; similar to transcriptional regulators from the zinc cluster (binuclear cluster) family; null mutant is sensitive to caffeine.


ensembl_gene_id: YKL223W
symbol: YKL223W
gene_biotype: protein_coding
description:
  Putative UPF0377 protein YKL223W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; Belongs to the UPF0377 family.


ensembl_gene_id: YKL224C
symbol: PAU16
gene_biotype: protein_coding
description:
  Seripauperin-16; Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions; SWAT-GFP and mCherry fusion proteins localize to the vacuole; Belongs to the SRP1/TIP1 family. Seripauperin subfamily.


ensembl_gene_id: YKL225W
symbol: YKL225W
gene_biotype: protein_coding
description:
  Putative UPF0320 protein YKL225W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YKR001C
symbol: VPS1
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 1; Dynamin-like GTPase required for vacuolar sorting; also involved in actin cytoskeleton organization, endocytosis, late Golgi-retention of some proteins, regulation of peroxisome biogenesis.


ensembl_gene_id: YKR002W
symbol: PAP1
gene_biotype: protein_coding
description:
  Poly(A) polymerase; one of three factors required for mRNA 3'-end polyadenylation, forms multiprotein complex with polyadenylation factor I (PF I), also required for mRNA nuclear export; may also polyadenylate rRNAs; required for gene looping.


ensembl_gene_id: YKR003W
symbol: OSH6
gene_biotype: protein_coding
description:
  Member of an oxysterol-binding protein family; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability; GFP-fusion protein localizes to the cell periphery; overexpression extends lifespan by promoting vacuolar fusion; OSH6 has a paralog, OSH7, that arose from the whole genome duplication.


ensembl_gene_id: YKR007W
symbol: MEH1
gene_biotype: protein_coding
description:
  Protein MEH1; Component of the EGO and GSE complexes; EGO is involved in the regulation of microautophagy and GSE is required for proper sorting of amino acid permease Gap1p; loss results in a defect in vacuolar acidification.


ensembl_gene_id: YKR008W
symbol: RSC4
gene_biotype: protein_coding
description:
  Chromatin structure-remodeling complex subunit RSC4; Component of the RSC chromatin remodeling complex; found in close proximity to nucleosomal DNA; displaced from the surface of nucleosomal DNA after chromatin remodeling; acetylated (K25) by Gcn5p, altering replication stress tolerance; contains tandem bromodomains that recognize histone H3 acetylated on K14 (H3K14ac) by Gcn5p.


ensembl_gene_id: YKR009C
symbol: FOX2
gene_biotype: protein_coding
description:
  Peroxisomal hydratase-dehydrogenase-epimerase; 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase; multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; mutation is functionally complemented by human HSD17B4.


ensembl_gene_id: YKR010C
symbol: TOF2
gene_biotype: protein_coding
description:
  Topoisomerase 1-associated factor 2; Protein required for rDNA silencing and mitotic rDNA condensation; stimulates Cdc14p phosphatase activity and biphasic release to promote rDNA repeat segregation; required for condensin recruitment to the replication fork barrier site; TOF2 has a paralog, NET1, that arose from the whole genome duplication; To yeast YJL076w.


ensembl_gene_id: YKR011C
symbol: YKR011C
gene_biotype: protein_coding
description:
  Uncharacterized protein YKR011C; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YKR012C
symbol: YKR012C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YKR012C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PRY2.


ensembl_gene_id: YKR013W
symbol: PRY2
gene_biotype: protein_coding
description:
  Sterol binding protein involved in the export of acetylated sterols; secreted glycoprotein and member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); sterol export function is redundant with that of PRY1; may be involved in detoxification of hydrophobic compounds; PRY2 has a paralog, PRY1, that arose from the whole genome duplication.


ensembl_gene_id: YKR014C
symbol: YPT52
gene_biotype: protein_coding
description:
  GTP-binding protein YPT52; Endosomal Rab family GTPase; required for vacuolar protein sorting, endocytosis and multivesicular body (MVB) biogenesis and sorting; required for localization of the CORVET complex to endosomes; involved in autophagy and ionic stress tolerance; similar to Vps21p and Ypt53p; mammalian Rab5 homolog; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YKR016W
symbol: MIC60
gene_biotype: protein_coding
description:
  Component of the MICOS complex; MICOS (formerly MINOS or MitOS) is a mitochondrial inner membrane complex that extends into the intermembrane space and has a role in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane; Mic60p is also involved in import of intermembrane space (IMS) proteins, probably by positioning Mia40p relative to the TOM complex to receive incoming proteins; ortholog of mammalian mitofilin.


ensembl_gene_id: YKR017C
symbol: HEL1
gene_biotype: protein_coding
description:
  RING finger ubiquitin ligase (E3); involved in ubiquitination and degradation of excess histones; interacts with Ubc4p and Rad53p; null mutant sensitive to hydroxyurea (HU); Belongs to the RBR family.


ensembl_gene_id: YKR018C
symbol: YKR018C
gene_biotype: protein_coding
description:
  IML2-like protein YKR018C; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress; YKR018C has a paralog, IML2, that arose from the whole genome duplication.


ensembl_gene_id: YKR019C
symbol: IRS4
gene_biotype: protein_coding
description:
  Increased rDNA silencing protein 4; EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication.


ensembl_gene_id: YKR020W
symbol: VPS51
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 51; Component of the GARP (Golgi-associated retrograde protein) complex; GARP is required for the recycling of proteins from endosomes to the late Golgi, and for mitosis after DNA damage induced checkpoint arrest; links the (VFT/GARP) complex to the SNARE Tlg1p; members of the GARP complex are Vps51p-Vps52p-Vps53p-Vps54p.


ensembl_gene_id: YKR021W
symbol: ALY1
gene_biotype: protein_coding
description:
  Arrestin-related trafficking adapter 6; Alpha arrestin, substrate of calcineurin; controls nutrient-mediated intracellular sorting of permease Gap1p; interacts with AP-1 subunit Apl4p; dephosphorylation of Aly1p required for the endocytosis of Dip5p; may regulate endocytosis of plasma membrane proteins by recruiting ubiquitin ligase Rsp5p to plasma membrane targets; ALY1 has a paralog, ALY2, that arose from the whole genome duplication.


ensembl_gene_id: YKR022C
symbol: NTR2
gene_biotype: protein_coding
description:
  Pre-mRNA-splicing factor NTR2; Essential protein that forms a dimer with Ntr1p; also forms a trimer, with Ntr2p and the DExD/H-box RNA helicase Prp43p, that is involved in spliceosome disassembly.


ensembl_gene_id: YKR023W
symbol: YKR023W
gene_biotype: protein_coding
description:
  Uncharacterized protein YKR023W; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies.


ensembl_gene_id: YKR024C
symbol: DBP7
gene_biotype: protein_coding
description:
  Putative ATP-dependent RNA helicase of the DEAD-box family; involved in ribosomal biogenesis; required at post-transcriptional step for efficient retrotransposition; essential for growth under anaerobic conditions.


ensembl_gene_id: YKR026C
symbol: GCN3
gene_biotype: protein_coding
description:
  Alpha subunit of translation initiation factor eIF2B; guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; positive regulator of GCN4 expression; assembles into filaments with Gcd2p, Gcd6p, Gcd7p, and Sui2p as cells approach stationary phase and under cytosolic acidification and starvation conditions; human homolog EIF2B1 can complement yeast null mutant; Belongs to the eIF-2B alpha/beta/delta subunits family.


ensembl_gene_id: YKR027W
symbol: BCH2
gene_biotype: protein_coding
description:
  Protein BCH2; Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; BCH2 has a paralog, CHS6, that arose from the whole genome duplication.


ensembl_gene_id: YKR028W
symbol: SAP190
gene_biotype: protein_coding
description:
  SIT4-associating protein SAP190; Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p; SAP190 has a paralog, SAP185, that arose from the whole genome duplication.


ensembl_gene_id: YKR029C
symbol: SET3
gene_biotype: protein_coding
description:
  Defining member of the SET3 histone deacetylase complex; which is a meiosis-specific repressor of sporulation genes; necessary for efficient transcription by RNAPII; one of two yeast proteins that contains both SET and PHD domains; SET3 has a paralog, SET4, that arose from the whole genome duplication.


ensembl_gene_id: YKR030W
symbol: GMH1
gene_biotype: protein_coding
description:
  Golgi membrane protein of unknown function; interacts with Gea1p and Gea2p; required for localization of Gea2p; computational analysis suggests a possible role in either cell wall synthesis or protein-vacuolar targeting; Belongs to the unc-50 family.


ensembl_gene_id: YKR031C
symbol: SPO14
gene_biotype: protein_coding
description:
  Phospholipase D; catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid; involved in Sec14p-independent secretion; required for meiosis and spore formation; differently regulated in secretion and meiosis; participates in transcription initiation and/or early elongation of specific genes; interacts with foot domain of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions.


ensembl_gene_id: YKR032W
symbol: YKR032W
gene_biotype: protein_coding
description:
  Uncharacterized protein YKR032W; Putative protein of unknown function; conserved among S. cerevisiae strains.


ensembl_gene_id: YKR033C
symbol: YKR033C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YKR033C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene DAL80.


ensembl_gene_id: YKR034W
symbol: DAL80
gene_biotype: protein_coding
description:
  Nitrogen regulatory protein DAL80; Negative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding family, forms homodimers and heterodimers with Gzf3p; DAL80 has a paralog, GZF3, that arose from the whole genome duplication.


ensembl_gene_id: YKR035C
symbol: OPI8
gene_biotype: protein_coding
description:
  Putative uncharacterized protein OPI8; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified gene DID2/YKR035W-A.


ensembl_gene_id: YKR035W-A
symbol: DID2
gene_biotype: protein_coding
description:
  Class E protein of the vacuolar protein-sorting (Vps) pathway; binds Vps4p and directs it to dissociate ESCRT-III complexes; forms a functional and physical complex with Ist1p; human ortholog may be altered in breast tumors.


ensembl_gene_id: YKR036C
symbol: CAF4
gene_biotype: protein_coding
description:
  CCR4-associated factor 4; WD40 repeat-containing protein associated with the CCR4-NOT complex; interacts in a Ccr4p-dependent manner with Ssn2p; also interacts with Fis1p, Mdv1p and Dnm1p and plays a role in mitochondrial fission; CAF4 has a paralog, MDV1, that arose from the whole genome duplication.


ensembl_gene_id: YKR038C
symbol: KAE1
gene_biotype: protein_coding
description:
  tRNA N6-adenosine threonylcarbamoyltransferase; Highly conserved ATPase of HSP70/DnaK family; essential functional component of the EKC/KEOPS complex, with Bud32p, Cgi121p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and telomeric TG1-3 recombination; may have role in transcription.


ensembl_gene_id: YKR039W
symbol: GAP1
gene_biotype: protein_coding
description:
  General amino acid permease; Gap1p senses the presence of amino acid substrates to regulate localization to the plasma membrane when needed; essential for invasive growth.


ensembl_gene_id: YKR040C
symbol: YKR040C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YKR040C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YKR041W.


ensembl_gene_id: YKR041W
symbol: YKR041W
gene_biotype: protein_coding
description:
  Uncharacterized protein YKR041W; Protein of unknown function; localizes to the mitotic spindle; overexpression of YKR041W affects endocytic protein trafficking.


ensembl_gene_id: YKR042W
symbol: UTH1
gene_biotype: protein_coding
description:
  Probable secreted beta-glucosidase UTH1; Mitochondrial inner membrane protein; role in mitophagy is disputed; implicated in cell wall biogenesis, the oxidative stress response, life span during starvation, and cell death; SUN family member; UTH1 has a paralog, NCA3, that arose from the whole genome duplication.


ensembl_gene_id: YKR043C
symbol: SHB17
gene_biotype: protein_coding
description:
  Sedoheptulose bisphosphatase involved in riboneogenesis; dephosphorylates sedoheptulose 1,7-bisphosphate, which is converted via the nonoxidative pentose phosphate pathway to ribose-5-phosphate; facilitates the conversion of glycolytic intermediates to pentose phosphate units; also has fructose 1,6-bisphosphatase activity but this is probably not biologically relevant, since deletion does not affect FBP levels; GFP-fusion protein localizes to the cytoplasm and nucleus.


ensembl_gene_id: YKR044W
symbol: UIP5
gene_biotype: protein_coding
description:
  Protein of unknown function that interacts with Ulp1p; a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates.


ensembl_gene_id: YKR045C
symbol: YKR045C
gene_biotype: protein_coding
description:
  Uncharacterized protein YKR045C; Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm.


ensembl_gene_id: YKR046C
symbol: PET10
gene_biotype: protein_coding
description:
  Protein of unknown function that localizes to lipid particles; localization suggests a role in lipid metabolism; expression pattern suggests a role in respiratory growth; computational analysis of large-scale protein-protein interaction data suggests a role in ATP/ADP exchange.


ensembl_gene_id: YKR047W
symbol: YKR047W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YKR047W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NAP1.


ensembl_gene_id: YKR048C
symbol: NAP1
gene_biotype: protein_coding
description:
  Nucleosome assembly protein; Histone chaperone; involved in histone exchange by removing and replacing histone H2A-H2B dimers or histone variant dimers from assembled nucleosomes; involved in the transport of H2A and H2B histones to the nucleus; required for the regulation of microtubule dynamics during mitosis; interacts with mitotic cyclin Clb2p; controls bud morphogenesis; phosphorylated by CK2; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YKR049C
symbol: FMP46
gene_biotype: protein_coding
description:
  Putative redox protein containing a thioredoxin fold; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Belongs to the FMP46 family.


ensembl_gene_id: YKR050W
symbol: TRK2
gene_biotype: protein_coding
description:
  Component of the Trk1p-Trk2p potassium transport system; contributes to K(+) supply and maintenance of plasma-membrane potential; TRK2 has a paralog, TRK1, that arose from the whole genome duplication.


ensembl_gene_id: YKR052C
symbol: MRS4
gene_biotype: protein_coding
description:
  Mitochondrial RNA-splicing protein MRS4; Iron transporter of the mitochondrial carrier family; mediates Fe2+ transport across the inner mitochondrial membrane; active under low-iron conditions; may transport other cations; protein abundance increases in response to DNA replication stress; MRS4 has a paralog, MRS3, that arose from the whole genome duplication.


ensembl_gene_id: YKR053C
symbol: YSR3
gene_biotype: protein_coding
description:
  Dihydrosphingosine 1-phosphate phosphatase; membrane protein involved in sphingolipid metabolism; YSR3 has a paralog, LCB3, that arose from the whole genome duplication; Belongs to the type 2 lipid phosphate phosphatase family.


ensembl_gene_id: YKR054C
symbol: DYN1
gene_biotype: protein_coding
description:
  Cytoplasmic heavy chain dynein; microtubule motor protein; member of the AAA+ protein family, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p; motility along microtubules inhibited by She1p.


ensembl_gene_id: YKR055W
symbol: RHO4
gene_biotype: protein_coding
description:
  GTP-binding protein RHO4; Non-essential small GTPase; member of the Rho/Rac subfamily of Ras-like proteins; likely to be involved in the establishment of cell polarity; has long N-terminal extension that plays an important role in Rho4p function and is shared with Rho4 homologs in other yeasts and filamentous fungi.


ensembl_gene_id: YKR056W
symbol: TRM2
gene_biotype: protein_coding
description:
  tRNA methyltransferase; 5-methylates the uridine residue at position 54 of tRNAs and may also have a role in tRNA stabilization or maturation; endo-exonuclease with a role in DNA repair; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.


ensembl_gene_id: YKR057W
symbol: RPS21A
gene_biotype: protein_coding
description:
  Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21A has a paralog, RPS21B, that arose from the whole genome duplication.


ensembl_gene_id: YKR058W
symbol: GLG1
gene_biotype: protein_coding
description:
  Glycogenin-1; Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; SWAT-GFP and mCherry fusion proteins localize to the cell periphery and vacuole respectively; similar to mammalian glycogenin; GLG1 has a paralog, GLG2, that arose from the whole genome duplication.


ensembl_gene_id: YKR059W
symbol: TIF1
gene_biotype: protein_coding
description:
  Translation initiation factor eIF4A; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G; protein abundance increases in response to DNA replication stress; TIF1 has a paralog, TIF2, that arose from the whole genome duplication.


ensembl_gene_id: YKR060W
symbol: UTP30
gene_biotype: protein_coding
description:
  Ribosome biogenesis protein UTP30; Putative subunit of U3-containing 90S preribosome complex; complex is involved in production of 18S rRNA and assembly of small ribosomal subunit; Belongs to the universal ribosomal protein uL1 family. Highly divergent.


ensembl_gene_id: YKR061W
symbol: KTR2
gene_biotype: protein_coding
description:
  Probable mannosyltransferase KTR2; Mannosyltransferase involved in N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; KTR2 has a paralog, YUR1, that arose from the whole genome duplication.


ensembl_gene_id: YKR062W
symbol: TFA2
gene_biotype: protein_coding
description:
  TFIIE small subunit; involved in RNA polymerase II transcription initiation; Belongs to the TFIIE beta subunit family.


ensembl_gene_id: YKR063C
symbol: LAS1
gene_biotype: protein_coding
description:
  Protein LAS1; Endonuclease involved in pre-rRNA processing at both ends of ITS2; functions with Grc3p in a conserved mechanism to modulate rRNA processing and ribosome biogenesis; may coordinate the action of the Rat1p-Rai1p exoRNAse; required for the G1/S cell cycle transition; human ortholog is Las1L; mutants require the SSD1-v allele for viability.


ensembl_gene_id: YKR064W
symbol: OAF3
gene_biotype: protein_coding
description:
  Oleate activated transcription factor 3; Putative transcriptional repressor with Zn(2)-Cys(6) finger; negatively regulates transcription in response to oleate levels, based on mutant phenotype and localization to oleate-responsive promoters; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; forms nuclear foci upon DNA replication stress.


ensembl_gene_id: YKR065C
symbol: PAM17
gene_biotype: protein_coding
description:
  Presequence translocated-associated motor subunit PAM17, mitochondrial; Constituent of the TIM23 complex; proposed alternatively to be a component of the import motor (PAM complex) or to interact with and modulate the core TIM23 (Translocase of the Inner mitochondrial Membrane) complex; protein abundance increases in response to DNA replication stress; Belongs to the PAM17 family.


ensembl_gene_id: YKR066C
symbol: CCP1
gene_biotype: protein_coding
description:
  Mitochondrial cytochrome-c peroxidase; degrades reactive oxygen species in mitochondria, involved in the response to oxidative stress.


ensembl_gene_id: YKR067W
symbol: GPT2
gene_biotype: protein_coding
description:
  Glycerol-3-phosphate O-acyltransferase 2; Glycerol-3-phosphate/dihydroxyacetone phosphate sn-1 acyltransferase; located in lipid particles and the ER; involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone in lipid biosynthesis; the most conserved motifs and functionally relevant residues are oriented towards the ER lumen; Belongs to the GPAT/DAPAT family.


ensembl_gene_id: YKR068C
symbol: BET3
gene_biotype: protein_coding
description:
  Core component of transport protein particle (TRAPP) complexes I-III; TRAPP complexes are related multimeric guanine nucleotide-exchange factors for the GTPase Ypt1, regulating ER-Golgi traffic (TRAPPI), intra-Golgi traffic (TRAPPII), endosome-Golgi traffic (TRAPPII and III) and autophagy (TRAPPIII); hydrophilic homodimeric protein that acts in conjunction with SNARE proteins in targeting and fusion of ER to Golgi transport vesicles.


ensembl_gene_id: YKR069W
symbol: MET1
gene_biotype: protein_coding
description:
  Uroporphyrinogen-III C-methyltransferase; S-adenosyl-L-methionine uroporphyrinogen III transmethylase; involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis; Belongs to the precorrin methyltransferase family.


ensembl_gene_id: YKR070W
symbol: YKR070W
gene_biotype: protein_coding
description:
  Uncharacterized protein YKR070W; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies.


ensembl_gene_id: YKR071C
symbol: DRE2
gene_biotype: protein_coding
description:
  Component of the cytosolic Fe-S protein assembly (CIA) machinery; contains an Fe-S cluster that receives electrons from NADPH via the action of Tah18p in an early step in the CIA pathway; ortholog of human Ciapin1; protein abundance increases in response to DNA replication stress; inviability of the null mutant is functionally complemented by human CIAPIN1.


ensembl_gene_id: YKR072C
symbol: SIS2
gene_biotype: protein_coding
description:
  Phosphopantothenoylcysteine decarboxylase subunit SIS2; Negative regulatory subunit of protein phosphatase 1 (Ppz1p); involved in coenzyme A biosynthesis; subunit of phosphopantothenoylcysteine decarboxylase (PPCDC: Cab3p, Sis2p, Vhs3p) complex and the CoA-Synthesizing Protein Complex (CoA-SPC: Cab2p, Cab3p, Cab4p, Cab5p, Sis2p and Vhs3p); SIS2 has a paralog, VHS3, that arose from the whole genome duplication.


ensembl_gene_id: YKR073C
symbol: YKR073C
gene_biotype: protein_coding
description:
  Uncharacterized protein YKR073C; Putative protein of unknown function; conserved across S. cerevisiae strains.


ensembl_gene_id: YKR074W
symbol: AIM29
gene_biotype: protein_coding
description:
  Altered inheritance rate of mitochondria protein 29; Protein of unknown function; epitope-tagged protein localizes to the cytoplasm; YKR074W is not an essential gene; null mutant displays elevated frequency of mitochondrial genome loss.


ensembl_gene_id: YKR075C
symbol: YKR075C
gene_biotype: protein_coding
description:
  Uncharacterized protein YKR075C; Protein of unknown function; similar to Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; YKR075C has a paralog, YOR062C, that arose from the whole genome duplication.


ensembl_gene_id: YKR075W-A
symbol: YKR075W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YKR075W-A; Dubious open reading frame unlikely to encode a protein; completely overlaps the uncharacterized gene YKR075C; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching.


ensembl_gene_id: YKR076W
symbol: ECM4
gene_biotype: protein_coding
description:
  Glutathione S-transferase omega-like 2; S-glutathionyl-(chloro)hydroquinone reductase (GS-HQR); glutathione transferase involved in cell-surface biosynthesis and architecture; catalyzes glutathione (GSH)-dependent reduction of GS-trichloro-p-hydroquinone to trichloro-p-hydroquinone; expression upregulated upon exposure to genotoxic agents, such as methyl methanesulfonate, cisplatin and bleomycin; not an essential gene; similar to YGR154C; green fluorescent protein (GFP)-fusion protein localizes to cytoplasm; Belongs to the GST superfamily. Omega family.


ensembl_gene_id: YKR077W
symbol: MSA2
gene_biotype: protein_coding
description:
  Putative transcriptional activator; interacts with G1-specific transcription factor MBF and G1-specific promoters; MSA2 has a paralog, MSA1, that arose from the whole genome duplication.


ensembl_gene_id: YKR078W
symbol: YKR078W
gene_biotype: protein_coding
description:
  Uncharacterized protein YKR078W; Cytoplasmic protein of unknown function; potential Cdc28p substrate; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P); YKR078W has a paralog, VPS5, that arose from the whole genome duplication.


ensembl_gene_id: YKR079C
symbol: TRZ1
gene_biotype: protein_coding
description:
  Ribonuclease Z; tRNA 3'-end processing endonuclease tRNase Z; also localized to mitochondria and interacts genetically with Rex2 exonuclease; homolog of the human candidate prostate cancer susceptibility gene ELAC2.


ensembl_gene_id: YKR080W
symbol: MTD1
gene_biotype: protein_coding
description:
  Methylenetetrahydrofolate dehydrogenase [NAD(+)]; NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase; plays a catalytic role in oxidation of cytoplasmic one-carbon units; expression is regulated by Bas1p and Bas2p, repressed by adenine, and may be induced by inositol and choline; Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.


ensembl_gene_id: YKR081C
symbol: RPF2
gene_biotype: protein_coding
description:
  Ribosome biogenesis protein RPF2; Essential protein involved in rRNA maturation and ribosomal assembly; involved in the processing of pre-rRNA and the assembly of the 60S ribosomal subunit; interacts with ribosomal protein L11; localizes predominantly to the nucleolus; constituent of 66S pre-ribosomal particles.


ensembl_gene_id: YKR082W
symbol: NUP133
gene_biotype: protein_coding
description:
  Nucleoporin NUP133; Subunit of Nup84p subcomplex of nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis; is involved in establishment of a normal nucleocytoplasmic concentration gradient of GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at nuclear periphery, including double-strand break repair, transcription and chromatin silencing; relocalizes to cytosol in response to hypoxia; homolog of human NUP133; Belongs to the nucleoporin Nup133 family.


ensembl_gene_id: YKR084C
symbol: HBS1
gene_biotype: protein_coding
description:
  Elongation factor 1 alpha-like protein; GTPase with similarity to translation release factors; together with binding partner Dom34p, facilitates ribosomal subunit dissociation and peptidyl-tRNA release when translation is stalled, particularly in 3' UTRs; genetically implicated in mRNA no-go decay; HBS1 has a paralog, SKI7, that arose from the whole genome duplication.


ensembl_gene_id: YKR086W
symbol: PRP16
gene_biotype: protein_coding
description:
  DEAH-box RNA helicase involved in second catalytic step of splicing and in exon ligation; exhibits ATP-dependent RNA unwinding activity; mediates the release of Yju2p and Cwc25p in the second step; in the absence of ATP, stabilizes the binding of Cwc25p to the spliceosome in the first catalytic step; missense mutation in human ortholog DHX38 associated with early-onset retinitis pigmentosa; Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily.


ensembl_gene_id: YKR087C
symbol: OMA1
gene_biotype: protein_coding
description:
  Metalloendopeptidase of the mitochondrial inner membrane; important for adaptive responses to various homeostatic insults, preservation of normal mitochondrial function under damage-eliciting conditions, and stability of respiratory supercomplexes; involved in turnover of membrane-embedded proteins; mediates degradation of Cox1p in coa2 mutant cells; zebrafish ortholog has a role in organ development and mouse ortholog is also required for respiratory supercomplex stability.


ensembl_gene_id: YKR088C
symbol: TVP38
gene_biotype: protein_coding
description:
  Integral membrane protein; localized to late Golgi vesicles along with the v-SNARE Tlg2p; required for asymmetric localization of Kar9p during mitosis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern.


ensembl_gene_id: YKR089C
symbol: TGL4
gene_biotype: protein_coding
description:
  Lipase 4; Multifunctional lipase/hydrolase/phospholipase; triacylglycerol lipase, steryl ester hydrolase, and Ca2+-independent phospholipase A2; catalyzes acyl-CoA dependent acylation of LPA to PA; required with Tgl3p for timely bud formation; phosphorylated and activated by Cdc28p; TGL4 has a paralog, TGL5, that arose from the whole genome duplication.


ensembl_gene_id: YKR090W
symbol: PXL1
gene_biotype: protein_coding
description:
  Paxillin-like protein 1; Protein that localizes to sites of polarized growth; required for selection and/or maintenance of polarized growth sites, may modulate signaling by the GTPases Cdc42p and Rho1p; contains LIM domains and has similarity to metazoan paxillin; relocalizes from bud neck to cytoplasm upon DNA replication stress.


ensembl_gene_id: YKR091W
symbol: SRL3
gene_biotype: protein_coding
description:
  Protein SRL3; GTB motif (G1/S transcription factor binding) containing protein; binds SBF-regulated promoters in hydroxyurea-treated cells; when overexpressed, suppresses the lethality of a rad53 null mutation; potential Cdc28p substrate; SRL3 has a paralog, WHI5, that arose from the whole genome duplication.


ensembl_gene_id: YKR092C
symbol: SRP40
gene_biotype: protein_coding
description:
  Suppressor protein SRP40; Nucleolar serine-rich protein; role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140.


ensembl_gene_id: YKR093W
symbol: PTR2
gene_biotype: protein_coding
description:
  Integral membrane peptide transporter; mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p.


ensembl_gene_id: YKR094C
symbol: RPL40B
gene_biotype: protein_coding
description:
  Ubiquitin-ribosomal 60S subunit protein L40B fusion protein; cleaved to yield ubiquitin and ribosomal protein L40B; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40B has a paralog, RPL40A, that arose from the whole genome duplication.


ensembl_gene_id: YKR095W
symbol: MLP1
gene_biotype: protein_coding
description:
  Myosin-like protein associated with the nuclear envelope; nuclear basket protein that connects the nuclear pore complex with the nuclear interior; involved with Tel1p in telomere length control; involved with Pml1p and Pml39p in nuclear retention of unspliced mRNAs; MLP1 has a paralog, MLP2, that arose from the whole genome duplication.


ensembl_gene_id: YKR095W-A
symbol: PCC1
gene_biotype: protein_coding
description:
  Component of the EKC/KEOPS protein complex; EKC/KEOPS complex is required for t6A tRNA modification and telomeric TG1-3 recombination; may have role in transcription; other complex members are Kae1p, Gon7p, Bud32p, and Cgi121p.


ensembl_gene_id: YKR096W
symbol: ESL2
gene_biotype: protein_coding
description:
  EST/SMG-like protein 2; hEST1A/B (SMG5/6)-like protein; contributes to environment-sensing adaptive gene expression responses; Esl2p and Esl1p contain a 14-3-3-like domain and a putative PilT N-terminus ribonuclease domain; interacts with Pex14p; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; ESL2 has a paralog, ESL1, that arose from the whole genome duplication.


ensembl_gene_id: YKR097W
symbol: PCK1
gene_biotype: protein_coding
description:
  Phosphoenolpyruvate carboxykinase; key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol.


ensembl_gene_id: YKR098C
symbol: UBP11
gene_biotype: protein_coding
description:
  Ubiquitin carboxyl-terminal hydrolase 11; Ubiquitin-specific protease; cleaves ubiquitin from ubiquitinated proteins; UBP11 has a paralog, UBP7, that arose from the whole genome duplication.


ensembl_gene_id: YKR099W
symbol: BAS1
gene_biotype: protein_coding
description:
  Myb-like DNA-binding protein BAS1; Myb-related transcription factor; involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes.


ensembl_gene_id: YKR100C
symbol: SKG1
gene_biotype: protein_coding
description:
  Suppressor of lethality of KEX2 GAS1 double null mutant protein 1; Transmembrane protein with a role in cell wall polymer composition; localizes on inner surface of plasma membrane at bud and in daughter cell; SKG1 has a paralog, AIM20, that arose from the whole genome duplication; Belongs to the SKG1 family.


ensembl_gene_id: YKR101W
symbol: SIR1
gene_biotype: protein_coding
description:
  Regulatory protein SIR1; Protein involved in silencing at mating-type loci HML and HMR; recruitment to silent chromatin requires interactions with Orc1p and with Sir4p, through a common Sir1p domain; binds to centromeric chromatin.


ensembl_gene_id: YKR102W
symbol: FLO10
gene_biotype: protein_coding
description:
  Flocculation protein FLO10; Member of the FLO family of cell wall flocculation proteins; not expressed in most lab strains; overproduction induces flocculation that can be inhibited by mannose, sucrose, or glucose; overproduction also promotes haploid invasive growth and diploid filamentous growth.


ensembl_gene_id: YKR103W
symbol: NFT1
gene_biotype: protein_coding
description:
  ABC transporter NFT1; Putative transporter of the MRP subfamily; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds; MRP stands for multidrug resistance-associated protein.


ensembl_gene_id: YKR104W
symbol: YKR104W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YKR104W; Putative transporter of the MRP subfamily; contains a stop codon in S288C; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds; MRP stands for multidrug resistance-associated protein; Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.


ensembl_gene_id: YKR105C
symbol: VBA5
gene_biotype: protein_coding
description:
  Vacuolar basic amino acid transporter 5; Plasma membrane protein of the Major Facilitator Superfamily (MFS); involved in amino acid uptake and drug sensitivity; VBA5 has a paralog, VBA3, that arose from a segmental duplication.


ensembl_gene_id: YKR106W
symbol: GEX2
gene_biotype: protein_coding
description:
  Glutathione exchanger 2; Proton:glutathione antiporter; localized to the vacuolar and plasma membranes; expressed at a very low level; potential role in resistance to oxidative stress and modulation of the PKA pathway; GEX2 has a paralog, GEX1, that arose from a segmental duplication.


ensembl_gene_id: YLL001W
symbol: DNM1
gene_biotype: protein_coding
description:
  Dynamin-related protein DNM1; Dynamin-related GTPase involved in mitochondrial organization; required for mitochondrial fission and inheritance; self assembles on the cytoplasmic face of mitochondrial tubules at sites where division will occur; participates in endocytosis and regulates peroxisome fission along with Vps1p; mutants in the human ortholog DNM1L, which mediates mitochondrial fission, peroxisomal division, autophagy, and mitophagy, are associated with slowly progressive infantile encephalopathy.


ensembl_gene_id: YLL002W
symbol: RTT109
gene_biotype: protein_coding
description:
  Histone acetyltransferase; critical for cell survival in presence of DNA damage during S phase, required for recovery after DSB repair; acetylates H3K56, H3K9; H3K56 acetylation activity required for expression homeostasis, buffering of mRNA synthesis rate against changes in gene dosage during S phase; involved in non-homologous end joining and regulation of Ty1 transposition; prevents hyper-amplification of rDNA; interacts physically with Vps75p.


ensembl_gene_id: YLL003W
symbol: SFI1
gene_biotype: protein_coding
description:
  Protein SFI1; Centrin (Cdc31p)-binding protein required for SPB duplication; localizes to the half-bridge of the spindle pole body (SPB); required for progression through G(2)-M transition; phosphorylated by Cdc28p-Clb2p and by Cdc5p; dephosphorylated by Cdc14p; has similarity to Xenopus laevis XCAP-C; Belongs to the SFI1 family.


ensembl_gene_id: YLL004W
symbol: ORC3
gene_biotype: protein_coding
description:
  Subunit of the origin recognition complex (ORC); ORC directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; Belongs to the ORC3 family.


ensembl_gene_id: YLL005C
symbol: SPO75
gene_biotype: protein_coding
description:
  Sporulation-specific protein 75; Meiosis-specific protein of unknown function; required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis; Belongs to the CSC1 (TC 1.A.17) family.


ensembl_gene_id: YLL006W
symbol: MMM1
gene_biotype: protein_coding
description:
  Maintenance of mitochondrial morphology protein 1; ER integral membrane protein, ERMES complex subunit; ERMES links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth; required for mitophagy; ERMES complex is often co-localized with peroxisomes and with concentrated areas of pyruvate dehydrogenase; Belongs to the MMM1 family.


ensembl_gene_id: YLL006W-A
symbol: YLL006W-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YLL006W-A; Putative protein of unknown function; identified by fungal homology and RT-PCR.


ensembl_gene_id: YLL007C
symbol: LMO1
gene_biotype: protein_coding
description:
  ELMO family protein LMO1; Homolog of mammalian ELMO (Engulfment and celL MOtility); upstream component for regulation through the small GTPase Rho5p; may form a complex with Dck1p that acts as a GEF for Rho5p; cytoplasmic protein that relocates to mitochondria under oxidative stress; implicated in mitophagy; not an essential protein.


ensembl_gene_id: YLL008W
symbol: DRS1
gene_biotype: protein_coding
description:
  ATP-dependent RNA helicase DRS1; Nucleolar DEAD-box protein required for ribosome assembly and function; including synthesis of 60S ribosomal subunits; constituent of 66S pre-ribosomal particles; Belongs to the DEAD box helicase family. DDX27/DRS1 subfamily.


ensembl_gene_id: YLL009C
symbol: COX17
gene_biotype: protein_coding
description:
  Copper metallochaperone that transfers copper to Sco1p and Cox11p; eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs; interacts with the MICOS complex, and interaction is promoted by copper ions; human homolog COX17 partially complements yeast null mutant.


ensembl_gene_id: YLL010C
symbol: PSR1
gene_biotype: protein_coding
description:
  Phosphatase PSR1; Plasma membrane associated protein phosphatase; involved in the general stress response; required along with binding partner Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p; PSR1 has a paralog, PSR2, that arose from the whole genome duplication.


ensembl_gene_id: YLL011W
symbol: SOF1
gene_biotype: protein_coding
description:
  Protein required for biogenesis of 40S (small) ribosomal subunit; has similarity to the beta subunit of trimeric G-proteins and the splicing factor Prp4p; essential gene; Belongs to the WD repeat DCAF13/WDSOF1 family.


ensembl_gene_id: YLL012W
symbol: YEH1
gene_biotype: protein_coding
description:
  Sterol esterase 1; Steryl ester hydrolase; one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes; YEH1 has a paralog, YEH2, that arose from the whole genome duplication.


ensembl_gene_id: YLL013C
symbol: PUF3
gene_biotype: protein_coding
description:
  mRNA-binding protein PUF3; Protein of the mitochondrial outer surface; links the Arp2/3 complex with the mitochore during anterograde mitochondrial movement; also binds to and promotes degradation of mRNAs for select nuclear-encoded mitochondrial proteins.


ensembl_gene_id: YLL014W
symbol: EMC6
gene_biotype: protein_coding
description:
  Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm F33D4.7/EMC-6, fly CG11781, human TMEM93.


ensembl_gene_id: YLL015W
symbol: BPT1
gene_biotype: protein_coding
description:
  Bile pigment transporter 1; ABC type transmembrane transporter of MRP/CFTR family; found in vacuolar membrane, involved in the transport of unconjugated bilirubin and in heavy metal detoxification via glutathione conjugates, along with Ycf1p.


ensembl_gene_id: YLL018C
symbol: DPS1
gene_biotype: protein_coding
description:
  Aspartate--tRNA ligase, cytoplasmic; Aspartyl-tRNA synthetase, primarily cytoplasmic; homodimeric enzyme that catalyzes the specific aspartylation of tRNA(Asp); class II aminoacyl tRNA synthetase; binding to its own mRNA may confer autoregulation; shares five highly conserved amino acids with human that when mutated cause leukoencephalopathy characterized by hypomyelination with brain stem and spinal cord involvement and leg spasticity (HBSL); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.


ensembl_gene_id: YLL018C-A
symbol: COX19
gene_biotype: protein_coding
description:
  Protein required for cytochrome c oxidase assembly; located in the cytosol and mitochondrial intermembrane space; putative copper metallochaperone that delivers copper to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs.


ensembl_gene_id: YLL019C
symbol: KNS1
gene_biotype: protein_coding
description:
  Dual specificity protein kinase KNS1; Protein kinase involved in negative regulation of PolIII transcription; effector kinase of the TOR signaling pathway and phosphorylates Rpc53p to regulate ribosome and tRNA biosynthesis; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues; capable of autophosphorylation.


ensembl_gene_id: YLL019W-A
symbol: YLL019W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YLL019W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified gene KNS1.


ensembl_gene_id: YLL020C
symbol: YLL020C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YLL020C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene KNS1.


ensembl_gene_id: YLL021W
symbol: SPA2
gene_biotype: protein_coding
description:
  Protein SPA2; Component of the polarisome; functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; potential Cdc28p substrate; coding sequence contains length polymorphisms in different strains; SPA2 has a paralog, SPH1, that arose from the whole genome duplication.


ensembl_gene_id: YLL022C
symbol: HIF1
gene_biotype: protein_coding
description:
  HAT1-interacting factor 1; Non-essential component of the HAT-B histone acetyltransferase complex; localized to the nucleus; has a role in telomeric silencing; other members are Hat1p and Hat2p; Belongs to the NASP family.


ensembl_gene_id: YLL023C
symbol: POM33
gene_biotype: protein_coding
description:
  Pore membrane protein of 33 kDa; Transmembrane nucleoporin; involved in nuclear pore complex (NPC) distribution, assembly or stabilization; highly conserved across species, orthologous to human TMEM33 and paralogous to Per33p; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YLL024C
symbol: SSA2
gene_biotype: protein_coding
description:
  Heat shock protein SSA2; HSP70 family ATP-binding protein; involved in protein folding, vacuolar import of proteins; required for ubiquitin-dependent degradation of short-lived proteins; associated with chaperonin-containing T-complex; 98% identical to paralog Ssa1p with distinct functional specificity in propagation of yeast [URE3] prions and vacuolar-mediated degradation of gluconeogenesis enzymes; binds tRNA, has role in tRNA nuclear import during starvation.


ensembl_gene_id: YLL025W
symbol: PAU17
gene_biotype: protein_coding
description:
  Seripauperin-17; Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions; SWAT-GFP and mCherry fusion proteins localize to the vacuole; YLL025W is not an essential gene; Belongs to the SRP1/TIP1 family. Seripauperin subfamily.


ensembl_gene_id: YLL026W
symbol: HSP104
gene_biotype: protein_coding
description:
  Disaggregase; heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured, aggregated proteins; responsive to stresses including: heat, ethanol, and sodium arsenite; involved in [PSI+] propagation; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress; potentiated Hsp104p variants decrease TDP-43 proteotoxicity by eliminating its cytoplasmic aggregation; Belongs to the ClpA/ClpB family.


ensembl_gene_id: YLL027W
symbol: ISA1
gene_biotype: protein_coding
description:
  Iron-sulfur assembly protein 1; Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa2p and possibly Iba57p; isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency; depletion reduces growth on nonfermentable carbon sources; functional ortholog of bacterial A-type ISC proteins; human ISCA1 can complement isa1 null mutant.


ensembl_gene_id: YLL028W
symbol: TPO1
gene_biotype: protein_coding
description:
  Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; during oxidative stress exports spermine, spermidine from the cell, which controls timing of expression of stress-responsive genes; phosphorylation enhances activity and sorting to the plasma membrane; Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.


ensembl_gene_id: YLL029W
symbol: FRA1
gene_biotype: protein_coding
description:
  Putative Xaa-Pro aminopeptidase FRA1; Protein involved in negative regulation of iron regulon transcription; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; cytosolic; mutant fails to repress transcription of iron regulon and is defective in spore formation; Belongs to the peptidase M24B family.


ensembl_gene_id: YLL030C
symbol: RRT7
gene_biotype: protein_coding
description:
  Regulator of rDNA transcription protein 7; Putative protein of unknown function; conserved across S. cerevisiae strains; identified in a screen for mutants with increased levels of rDNA transcription.


ensembl_gene_id: YLL031C
symbol: GPI13
gene_biotype: protein_coding
description:
  GPI ethanolamine phosphate transferase 3; ER membrane localized phosphoryltransferase; adds phosphoethanolamine onto the third mannose residue of the glycosylphosphatidylinositol (GPI) anchor precursor; similar to human PIG-O protein.


ensembl_gene_id: YLL032C
symbol: YLL032C
gene_biotype: protein_coding
description:
  KH domain-containing protein YLL032C; Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene.


ensembl_gene_id: YLL033W
symbol: IRC19
gene_biotype: protein_coding
description:
  Increased recombination centers protein 19; Protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci.


ensembl_gene_id: YLL034C
symbol: RIX7
gene_biotype: protein_coding
description:
  Ribosome biogenesis ATPase RIX7; Putative ATPase of the AAA family; required for export of pre-ribosomal large subunits from the nucleus; distributed between the nucleolus, nucleoplasm, and nuclear periphery depending on growth conditions.


ensembl_gene_id: YLL035W
symbol: GRC3
gene_biotype: protein_coding
description:
  Polynucleotide 5'-hydroxyl-kinase GRC3; Polynucleotide kinase present on rDNA; required for efficient transcription termination by RNA polymerase I; functions with Las1p in a conserved mechanism to modulate rRNA processing and ribosome biogenesis; required for cell growth; mRNA is cell-cycle regulated; Belongs to the Clp1 family. NOL9/GRC3 subfamily.


ensembl_gene_id: YLL036C
symbol: PRP19
gene_biotype: protein_coding
description:
  Pre-mRNA-processing factor 19; Splicing factor associated with the spliceosome; contains a U-box, a motif found in a class of ubiquitin ligases, and a WD40 domain; relocalizes to the cytosol in response to hypoxia; Belongs to the WD repeat PRP19 family.


ensembl_gene_id: YLL037W
symbol: YLL037W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YLL037W; Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential PRP19 gene encoding an RNA splicing factor.


ensembl_gene_id: YLL038C
symbol: ENT4
gene_biotype: protein_coding
description:
  Epsin-4; Protein of unknown function; contains an N-terminal epsin-like domain; proposed to be involved in the trafficking of Arn1p in the absence of ferrichrome.


ensembl_gene_id: YLL039C
symbol: UBI4
gene_biotype: protein_coding
description:
  Polyubiquitin; Ubiquitin; becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YLL040C
symbol: VPS13
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 13; Protein involved in prospore membrane morphogenesis; peripheral membrane protein that localizes to the prospore membrane and at numerous membrane contact sites; involved in sporulation, vacuolar protein sorting, prospore membrane formation during sporulation, and protein-Golgi retention; required for mitochondrial integrity; contains a PH-like domain; homologous to human CHAC and COH1 which are involved in Chorea-acanthocytosis and Cohen syndrome, respectively.


ensembl_gene_id: YLL041C
symbol: SDH2
gene_biotype: protein_coding
description:
  Iron-sulfur protein subunit of succinate dehydrogenase; the complex couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; other members are Sdh1p, Sdh3p, and Sdh4p.


ensembl_gene_id: YLL042C
symbol: ATG10
gene_biotype: protein_coding
description:
  Ubiquitin-like-conjugating enzyme ATG10; Conserved E2-like conjugating enzyme; mediates formation of the Atg12p-Atg5p conjugate, which is a critical step in autophagy; Belongs to the ATG10 family.


ensembl_gene_id: YLL043W
symbol: FPS1
gene_biotype: protein_coding
description:
  Glycerol uptake/efflux facilitator protein; Aquaglyceroporin, plasma membrane channel; involved in efflux of glycerol and xylitol, and in uptake of acetic acid, arsenite, and antimonite; key factor in maintaining redox balance by mediating passive diffusion of glycerol; phosphorylated by Hog1p MAPK under acetate stress; deletion improves xylose fermentation; regulated by Rgc1p and Ask10p, which are regulated by Hog1p phosphorylation under osmotic stress; phosphorylation by Ypk1p required to maintain an open state; Belongs to the MIP/aquaporin (TC 1.A.8) family.


ensembl_gene_id: YLL044W
symbol: YLL044W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YLL044W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; transcription of both YLL044W and the overlapping gene RPL8B is reduced in the gcr1 null mutant.


ensembl_gene_id: YLL045C
symbol: RPL8B
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L8B; required for processing of 27SA3 pre-rRNA to 27SB pre-rRNA during assembly of large ribosomal subunit; depletion leads to a turnover of pre-rRNA; L8 binds to Domain I of 25S and 5.8 S rRNAs; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8B has a paralog, RPL8A, that arose from the whole genome duplication.


ensembl_gene_id: YLL046C
symbol: RNP1
gene_biotype: protein_coding
description:
  Ribonucleoprotein that contains two RNA recognition motifs (RRM); RNP1 has a paralog, SBP1, that arose from the whole genome duplication.


ensembl_gene_id: YLL047W
symbol: YLL047W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YLL047W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified gene RNP1.


ensembl_gene_id: YLL048C
symbol: YBT1
gene_biotype: protein_coding
description:
  ATP-dependent bile acid permease; Transporter of the ATP-binding cassette (ABC) family; involved in bile acid transport; negative regulator of vacuole fusion; regulates release of lumenal Ca2+ stores; similar to mammalian bile transporters; YBT1 has a paralog, VMR1, that arose from the whole genome duplication.


ensembl_gene_id: YLL049W
symbol: LDB18
gene_biotype: protein_coding
description:
  Protein LDB18; Component of the dynactin complex; dynactin is required for dynein activity; null mutant exhibits defects in nuclear migration and spindle orientation and has reduced affinity for alcian blue dye; has homology to mammalian dynactin subunit p24.


ensembl_gene_id: YLL050C
symbol: COF1
gene_biotype: protein_coding
description:
  Cofilin, involved in pH-dependent actin filament depolarization; binds both actin monomers and filaments and severs filaments; involved in the selective sorting, export of the secretory cargo from the late golgi; genetically interacts with pmr1; thought to be regulated by phosphorylation at SER4; ubiquitous and essential in eukaryotes; Belongs to the actin-binding proteins ADF family.


ensembl_gene_id: YLL051C
symbol: FRE6
gene_biotype: protein_coding
description:
  Ferric reductase transmembrane component 6; Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels.


ensembl_gene_id: YLL052C
symbol: AQY2
gene_biotype: protein_coding
description:
  Aquaporin-like protein 2; Water channel that mediates water transport across cell membranes; only expressed in proliferating cells; controlled by osmotic signals; may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains; Belongs to the MIP/aquaporin (TC 1.A.8) family.


ensembl_gene_id: YLL053C
symbol: YLL053C
gene_biotype: protein_coding
description:
  Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin.


ensembl_gene_id: YLL054C
symbol: YLL054C
gene_biotype: protein_coding
description:
  Uncharacterized transcriptional regulatory protein YLL054C; Putative protein of unknown function with similarity to Pip2p; an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene.


ensembl_gene_id: YLL055W
symbol: YCT1
gene_biotype: protein_coding
description:
  High-affinity cysteine-specific transporter; has similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene; Belongs to the major facilitator superfamily. Allantoate permease family.


ensembl_gene_id: YLL056C
symbol: YLL056C
gene_biotype: protein_coding
description:
  Uncharacterized protein YLL056C; Putative protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p and genes involved in pleiotropic drug resistance (PDR); expression is induced in cells treated with the mycotoxin patulin; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively.


ensembl_gene_id: YLL057C
symbol: JLP1
gene_biotype: protein_coding
description:
  Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase; involved in sulfonate catabolism for use as a sulfur source; contains sequence that resembles a J domain (typified by the E. coli DnaJ protein); induced by sulphur starvation.


ensembl_gene_id: YLL058W
symbol: YLL058W
gene_biotype: protein_coding
description:
  Putative protein of unknown function with similarity to Str2p; Str2p is a cystathionine gamma-synthase important in sulfur metabolism; YLL058W is not an essential gene.


ensembl_gene_id: YLL059C
symbol: YLL059C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YLL059C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YLL060C
symbol: GTT2
gene_biotype: protein_coding
description:
  Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p; protein abundance increases in response to DNA replication stress; Belongs to the GST superfamily.


ensembl_gene_id: YLL061W
symbol: MMP1
gene_biotype: protein_coding
description:
  High-affinity S-methylmethionine permease; required for utilization of S-methylmethionine as a sulfur source; has similarity to S-adenosylmethionine permease Sam3p; Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.


ensembl_gene_id: YLL062C
symbol: MHT1
gene_biotype: protein_coding
description:
  Homocysteine S-methyltransferase 1; S-methylmethionine-homocysteine methyltransferase; functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio.


ensembl_gene_id: YLL063C
symbol: AYT1
gene_biotype: protein_coding
description:
  Acetyltransferase; catalyzes trichothecene 3-O-acetylation, suggesting a possible role in trichothecene biosynthesis.


ensembl_gene_id: YLL064C
symbol: PAU18
gene_biotype: protein_coding
description:
  Seripauperin-18; Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions; identical to Pau6p; Belongs to the SRP1/TIP1 family. Seripauperin subfamily.


ensembl_gene_id: YLL065W
symbol: YLL065W
gene_biotype: protein_coding
description:
  Putative UPF0320 protein YLL065W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps chromosome XII telomeric element core sequences.


ensembl_gene_id: YLL066W-A
symbol: YLL066W-A
gene_biotype: protein_coding
description:
  Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the uncharacterized ORF YLL066C.


ensembl_gene_id: YLL066W-B
symbol: YLL066W-B
gene_biotype: protein_coding
description:
  Uncharacterized protein YLL066W-B; Putative protein of unknown function; overexpression causes a cell cycle delay or arrest.


ensembl_gene_id: YLL067W-A
symbol: YLL067W-A
gene_biotype: protein_coding
description:
  Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps YLL067C.


ensembl_gene_id: YLR001C
symbol: YLR001C
gene_biotype: protein_coding
description:
  FAS1 domain-containing protein YLR001C; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; predicted to be palmitoylated.


ensembl_gene_id: YLR002C
symbol: NOC3
gene_biotype: protein_coding
description:
  Nucleolar complex-associated protein 3; Subunit of a nuclear complex with Noc2p and pre-replicative complexes; the Noc2p-Noc3p complex binds to 66S ribosomal precursors to mediate their maturation and intranuclear transport; binds to chromatin at active replication origins, and is required for pre-RC formation and maintenance during DNA replication licensing.


ensembl_gene_id: YLR003C
symbol: CMS1
gene_biotype: protein_coding
description:
  Protein CMS1; Putative subunit of the 90S preribosome processome complex; overexpression rescues supressor mutant of mcm10; null mutant is viable; relocalizes from nucleus to cytoplasm upon DNA replication stress.


ensembl_gene_id: YLR004C
symbol: THI73
gene_biotype: protein_coding
description:
  Thiamine pathway transporter THI73; Putative plasma membrane permease; proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs.


ensembl_gene_id: YLR005W
symbol: SSL1
gene_biotype: protein_coding
description:
  Subunit of the core form of RNA polymerase transcription factor TFIIH; has both protein kinase and DNA-dependent ATPase/helicase activities; essential for transcription and nucleotide excision repair; interacts with Tfb4p; Belongs to the GTF2H2 family.


ensembl_gene_id: YLR006C
symbol: SSK1
gene_biotype: protein_coding
description:
  Osmolarity two-component system protein SSK1; Cytoplasmic phosphorelay intermediate osmosensor and regulator; part of a two-component signal transducer that mediates osmosensing via a phosphorelay mechanism; required for mitophagy; dephosphorylated form is degraded by the ubiquitin-proteasome system; potential Cdc28p substrate.


ensembl_gene_id: YLR007W
symbol: NSE1
gene_biotype: protein_coding
description:
  Non-structural maintenance of chromosomes element 1; Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair.


ensembl_gene_id: YLR008C
symbol: PAM18
gene_biotype: protein_coding
description:
  Subunit of the import motor (PAM complex); the PAM complex is a  component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); essential J-protein cochaperone that stimulates Ssc1p ATPase activity to drive import; inhibited by Pam16p.


ensembl_gene_id: YLR009W
symbol: RLP24
gene_biotype: protein_coding
description:
  Essential protein required for ribosomal large subunit biogenesis; associated with pre-60S ribosomal subunits; stimulates the ATPase activity of Afg2p, which is required for release of Rlp24p from the pre-60S particle; has similarity to Rpl24Ap and Rpl24Bp.


ensembl_gene_id: YLR010C
symbol: TEN1
gene_biotype: protein_coding
description:
  Telomere length regulation protein TEN1; Protein that regulates telomeric length; protects telomeric ends in a complex with Cdc13p and Stn1p; similar to human Ten1 which is critical for the telomeric function of the CST (Cdc13p-Stn1p-Ten1p) complex.


ensembl_gene_id: YLR011W
symbol: LOT6
gene_biotype: protein_coding
description:
  FMN-dependent NAD(P)H:quinone reductase; role in apoptosis-like cell death; may be involved in quinone detoxification; expression elevated at low temperature; sequesters the Cin5p transcription factor in the cytoplasm in complex with the proteasome under reducing conditions.


ensembl_gene_id: YLR013W
symbol: GAT3
gene_biotype: protein_coding
description:
  Protein containing GATA family zinc finger motifs; involved in spore wall assembly; sequence similarity to GAT4, and the double mutant gat3 gat4 exhibits reduced dityrosine fluorescence relative to the single mutants.


ensembl_gene_id: YLR014C
symbol: PPR1
gene_biotype: protein_coding
description:
  Pyrimidine pathway regulatory protein 1; Zinc finger transcription factor; contains a Zn(2)-Cys(6) binuclear cluster domain, positively regulates transcription of URA1, URA3, URA4, and URA10, which are involved in de novo pyrimidine biosynthesis, in response to pyrimidine starvation; activity may be modulated by interaction with Tup1p.


ensembl_gene_id: YLR015W
symbol: BRE2
gene_biotype: protein_coding
description:
  COMPASS component BRE2; Subunit of COMPASS (Set1C) complex; COMPASS methylates Lys4 of histone H3 and functions in silencing at telomeres; has a C-terminal Sdc1 Dpy-30 Interaction (SDI) domain that mediates binding to Sdc1p; similar to trithorax-group protein ASH2L.


ensembl_gene_id: YLR016C
symbol: PML1
gene_biotype: protein_coding
description:
  Pre-mRNA leakage protein 1; Subunit of the RES complex; RES complex is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p.


ensembl_gene_id: YLR017W
symbol: MEU1
gene_biotype: protein_coding
description:
  Methylthioadenosine phosphorylase (MTAP); catalyzes the initial step in the methionine salvage pathway; affects polyamine biosynthesis through regulation of ornithine decarboxylase (Spe1p) activity; regulates ADH2 gene expression; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.


ensembl_gene_id: YLR018C
symbol: POM34
gene_biotype: protein_coding
description:
  Nucleoporin POM34; Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication.


ensembl_gene_id: YLR019W
symbol: PSR2
gene_biotype: protein_coding
description:
  Probable phosphatase PSR2; Plasma membrane phosphatase involved in the general stress response; required with Psr1p and Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p; PSR2 has a paralog, PSR1, that arose from the whole genome duplication.


ensembl_gene_id: YLR020C
symbol: YEH2
gene_biotype: protein_coding
description:
  Sterol esterase 2; Steryl ester hydrolase; catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism; YEH2 has a paralog, YEH1, that arose from the whole genome duplication.


ensembl_gene_id: YLR021W
symbol: IRC25
gene_biotype: protein_coding
description:
  Proteasome chaperone 3; Component of a heterodimeric Poc4p-Irc25p chaperone; involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions; upregulates proteasome assembly in response to the unfolded protein response activated by mistargeting of proteins (UPRam); Belongs to the PSMG3 family.


ensembl_gene_id: YLR022C
symbol: SDO1
gene_biotype: protein_coding
description:
  Ribosome maturation protein SDO1; Guanine nucleotide exchange factor (GEF) for Ria1p; essential protein involved in ribosome maturation; with Ria1p, promotes release of Tif6p from 60S ribosomal subunits in the cytoplasm so that they can assemble with 40S subunits to generate mature ribosomes; ortholog of the human protein (SBDS) responsible for autosomal recessive Shwachman-Bodian-Diamond Syndrome; highly conserved across archaea and eukaryotes.


ensembl_gene_id: YLR023C
symbol: IZH3
gene_biotype: protein_coding
description:
  ADIPOR-like receptor IZH3; Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity; Belongs to the ADIPOR family.


ensembl_gene_id: YLR024C
symbol: UBR2
gene_biotype: protein_coding
description:
  Cytoplasmic ubiquitin-protein ligase (E3); component of the Mub1p-Ubr2p-Rad6p ubiquitin ligase complex required for the ubiquitination and degradation of Rpn4p; mediates formation of the ternary complex.


ensembl_gene_id: YLR025W
symbol: SNF7
gene_biotype: protein_coding
description:
  Vacuolar-sorting protein SNF7; One of four subunits of the ESCRT-III complex; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes; ESCRT-III stands for endosomal sorting complex required for transport III.


ensembl_gene_id: YLR026C
symbol: SED5
gene_biotype: protein_coding
description:
  Integral membrane protein SED5; cis-Golgi t-SNARE syntaxin; required for vesicular transport between the ER and the Golgi complex; binds at least 9 SNARE proteins.


ensembl_gene_id: YLR027C
symbol: AAT2
gene_biotype: protein_coding
description:
  Aspartate aminotransferase, cytoplasmic; Cytosolic aspartate aminotransferase involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.


ensembl_gene_id: YLR028C
symbol: ADE16
gene_biotype: protein_coding
description:
  Phosphoribosylaminoimidazolecarboxamide formyltransferase; Enzyme of 'de novo' purine biosynthesis; contains both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities; ADE16 has a paralog, ADE17, that arose from the whole genome duplication; ade16 ade17 mutants require adenine and histidine; Belongs to the PurH family.


ensembl_gene_id: YLR029C
symbol: RPL15A
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L15A; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15A has a paralog, RPL15B, that arose from the whole genome duplication.


ensembl_gene_id: YLR030W
symbol: YLR030W
gene_biotype: protein_coding
description:
  Putative protein of unknown function; S288C contains an in-frame stop codon between ORFs YLR030W and YLR031W.


ensembl_gene_id: YLR031W
symbol: YLR031W
gene_biotype: protein_coding
description:
  Putative protein of unknown function; S288C contains an in-frame stop codon between ORFs YLR030W and YLR031W; YLR031W has a paralog, YMR124W, that arose from the whole genome duplication.


ensembl_gene_id: YLR032W
symbol: RAD5
gene_biotype: protein_coding
description:
  DNA repair protein RAD5; DNA helicase/Ubiquitin ligase; involved in error-free DNA damage tolerance (DDT), replication fork regression during postreplication repair by template switching, error-prone translesion synthesis; promotes synthesis of free and PCNA-bound polyubiquitin chains by Ubc13p-Mms2p; forms nuclear foci upon DNA replication stress; associates with native telomeres, cooperates with homologous recombination in senescent cells; human homolog HLTF can complement yeast null mutant.


ensembl_gene_id: YLR033W
symbol: RSC58
gene_biotype: protein_coding
description:
  Chromatin structure-remodeling complex protein RSC58; Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance.


ensembl_gene_id: YLR034C
symbol: SMF3
gene_biotype: protein_coding
description:
  Iron transporter SMF3; Putative divalent metal ion transporter involved in iron homeostasis; transcriptionally regulated by metal ions; member of the Nramp family of metal transport proteins; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YLR035C
symbol: MLH2
gene_biotype: protein_coding
description:
  Protein involved in mismatch repair and meiotic recombination; only certain frameshift intermediates are mismatch repair substrates; forms a complex with Mlh1p.


ensembl_gene_id: YLR036C
symbol: YLR036C
gene_biotype: protein_coding
description:
  Uncharacterized protein YLR036C; Putative protein predicted to have transmembrane domains; interacts with HSP90 by yeast two-hybrid analysis; YLR036C is not an essential protein.


ensembl_gene_id: YLR037C
symbol: PAU23
gene_biotype: protein_coding
description:
  Seripauperin-23; Cell wall mannoprotein; has similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth; Belongs to the SRP1/TIP1 family. Seripauperin subfamily.


ensembl_gene_id: YLR038C
symbol: COX12
gene_biotype: protein_coding
description:
  Subunit VIb of cytochrome c oxidase; cytochrome c oxidase is also known as respiratory Complex IV and is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly of cytochrome c oxidase but not required for activity after assembly; phosphorylated; easily released from the intermembrane space, suggesting a loose association with Complex IV.


ensembl_gene_id: YLR039C
symbol: RIC1
gene_biotype: protein_coding
description:
  Guanine nucleotide exchange factor subunit RIC1; Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes.


ensembl_gene_id: YLR040C
symbol: AFB1
gene_biotype: protein_coding
description:
  A-factor barrier protein 1; MATalpha-specific a-factor blocker; contributes to mating efficiency under certain conditions; localizes to the cell wall; predicted to be a GPI-attached protein; upregulated by Mcm1p-Alpha1p transcription factor; partially overlaps the dubious ORF YLR041W; Belongs to the SRP1/TIP1 family.


ensembl_gene_id: YLR041W
symbol: YLR041W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YLR041W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YLR040C.


ensembl_gene_id: YLR042C
symbol: YLR042C
gene_biotype: protein_coding
description:
  Cell wall protein of unknown function; localizes to the cytoplasm; deletion improves xylose fermentation in industrially engineered strains; YLR042C is not an essential gene.


ensembl_gene_id: YLR043C
symbol: TRX1
gene_biotype: protein_coding
description:
  Thioredoxin-1; Cytoplasmic thioredoxin isoenzyme; part of thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p; required for ER-Golgi transport and vacuole inheritance; with Trx2p, facilitates mitochondrial import of small Tims Tim9p, Tim10p, Tim13p by maintaining them in reduced form; abundance increases iunder DNA replication stress; TRX1 has a paralog, TRX2, that arose from the whole genome duplication.


ensembl_gene_id: YLR044C
symbol: PDC1
gene_biotype: protein_coding
description:
  Major of three pyruvate decarboxylase isozymes; key enzyme in alcoholic fermentation; decarboxylates pyruvate to acetaldehyde; involved in amino acid catabolism; subject to glucose-, ethanol-, and autoregulation; activated by phosphorylation in response to glucose levels; N-terminally propionylated in vivo; Belongs to the TPP enzyme family.


ensembl_gene_id: YLR045C
symbol: STU2
gene_biotype: protein_coding
description:
  Protein STU2; Microtubule-associated protein (MAP) of the XMAP215/Dis1 family; regulates microtubule dynamics during spindle orientation and metaphase chromosome alignment; interacts with spindle pole body component Spc72p; Belongs to the TOG/XMAP215 family.


ensembl_gene_id: YLR046C
symbol: YLR046C
gene_biotype: protein_coding
description:
  Putative membrane protein; member of the fungal lipid-translocating exporter (LTE) family of proteins; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; YLR046C has a paralog, RTA1, that arose from the whole genome duplication.


ensembl_gene_id: YLR047C
symbol: FRE8
gene_biotype: protein_coding
description:
  Probable ferric reductase transmembrane component 8; Protein with sequence similarity to iron/copper reductases; involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p.


ensembl_gene_id: YLR048W
symbol: RPS0B
gene_biotype: protein_coding
description:
  Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2.


ensembl_gene_id: YLR050C
symbol: YLR050C
gene_biotype: protein_coding
description:
  Uncharacterized membrane protein YLR050C; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YLR050C is not an essential gene.


ensembl_gene_id: YLR051C
symbol: FCF2
gene_biotype: protein_coding
description:
  rRNA-processing protein FCF2; Nucleolar protein involved in the early steps of 35S rRNA processing; interacts with Faf1p; member of a transcriptionally co-regulated set of genes called the RRB regulon; essential gene.


ensembl_gene_id: YLR055C
symbol: SPT8
gene_biotype: protein_coding
description:
  Transcription factor SPT8; Subunit of the SAGA transcriptional regulatory complex; not present in SAGA-like complex SLIK/SALSA; required for SAGA-mediated inhibition at some promoters.


ensembl_gene_id: YLR056W
symbol: ERG3
gene_biotype: protein_coding
description:
  Delta(7)-sterol 5(6)-desaturase; C-5 sterol desaturase; glycoprotein that catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; transcriptionally down-regulated when ergosterol is in excess; mutants are viable, but cannot grow on non-fermentable carbon sources; substrate of HRD ubiquitin ligase; mutation is functionally complemented by human SC5D.


ensembl_gene_id: YLR057W
symbol: MNL2
gene_biotype: protein_coding
description:
  Putative endoplasmic reticulum mannosidase MNL2; Putative mannosidase involved in ER-associated protein degradation; localizes to the endoplasmic reticulum; sequence similarity with seven-hairpin glycosidase (GH47) family members, such as Mns1p and Mnl1p, that hydrolyze 1,2-linked alpha-D-mannose residues; non-essential gene.


ensembl_gene_id: YLR058C
symbol: SHM2
gene_biotype: protein_coding
description:
  Cytosolic serine hydroxymethyltransferase; converts serine to glycine plus 5,10 methylenetetrahydrofolate; major isoform involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis; Belongs to the SHMT family.


ensembl_gene_id: YLR059C
symbol: REX2
gene_biotype: protein_coding
description:
  Oligoribonuclease, mitochondrial; 3'-5' RNA exonuclease; involved in 3'-end processing of U4 and U5 snRNAs, 5S and 5.8S rRNAs, and RNase P and RNase MRP RNA; localized to mitochondria and null suppresses escape of mtDNA to nucleus in yme1 yme2 mutants; RNase D exonuclease.


ensembl_gene_id: YLR060W
symbol: FRS1
gene_biotype: protein_coding
description:
  Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase; forms a tetramer with Frs2p to generate active enzyme; able to hydrolyze mis-aminoacylated tRNA-Phe, which could contribute to translational quality control.


ensembl_gene_id: YLR061W
symbol: RPL22A
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L22A; required for translation of long 5' UTR of IME1 mRNA and meiotic entry; required for the oxidative stress response, pseudohyphal and invasive growth; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication.


ensembl_gene_id: YLR062C
symbol: BUD28
gene_biotype: protein_coding
description:
  Putative uncharacterized protein BUD28; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene RPL22A; diploid mutant displays a weak budding pattern phenotype in a systematic assay.


ensembl_gene_id: YLR063W
symbol: BMT6
gene_biotype: protein_coding
description:
  Methyltransferase required for m3U2843 methylation of the 25S rRNA; S-adenosylmethionine-dependent; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR063W is not an essential gene.


ensembl_gene_id: YLR064W
symbol: PER33
gene_biotype: protein_coding
description:
  Protein that localizes to the endoplasmic reticulum; also associates with the nuclear pore complex; deletion extends chronological lifespan; highly conserved across species, orthologous to human TMEM33 and paralogous to Pom33p; protein abundance increases in response to DNA replication stress; Belongs to the PER33/POM33 family.


ensembl_gene_id: YLR065C
symbol: ENV10
gene_biotype: protein_coding
description:
  Protein involved in SRP-independent targeting of substrates to the ER; component of an alternative ER targeting pathway that has partial functional redundancy with the GET pathway; preference for substrates with downstream transmembrane domains; interacts with Snd1p, Pho88p/Snd3p, and Sec61p-translocon subunits; can compensate for loss of SRP; role in the late endosome-vacuole interface; putative role in secretory protein quality control; Belongs to the TMEM208 family.


ensembl_gene_id: YLR066W
symbol: SPC3
gene_biotype: protein_coding
description:
  Subunit of signal peptidase complex; complex catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC22/23; other members of the complex are Spc1p, Spc2p, and Sec11p.


ensembl_gene_id: YLR067C
symbol: PET309
gene_biotype: protein_coding
description:
  Pentatricopeptide repeat-containing protein PET309, mitochondrial; Specific translational activator for the COX1 mRNA; binds to the COX1 mRNA; also influences stability of intron-containing COX1 primary transcripts; localizes to the mitochondrial inner membrane; contains 12 pentatricopeptide repeats (PPRs).


ensembl_gene_id: YLR068W
symbol: FYV7
gene_biotype: protein_coding
description:
  rRNA-processing protein FYV7; Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin.


ensembl_gene_id: YLR070C
symbol: XYL2
gene_biotype: protein_coding
description:
  D-xylulose reductase; Xylitol dehydrogenase; converts xylitol to D-xylulose; expression induced by xylose, even though this pentose sugar is not well utilized by S. cerevisiae; null mutant has cell wall defect.


ensembl_gene_id: YLR071C
symbol: RGR1
gene_biotype: protein_coding
description:
  Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for glucose repression, HO repression, RME1 repression and sporulation.


ensembl_gene_id: YLR072W
symbol: LAM6
gene_biotype: protein_coding
description:
  Membrane-anchored lipid-binding protein LAM6; Sterol transporter that transfers sterols between membranes; may regulate and coordinate formation of contact sites between organelles; localizes to ER-mitochondrial contact sites in a Tom70p- and Tom71p-dependent manner; mitochondrial localization requires GRAM domain; also localizes to ER-vacuole contact sites, in a Vac8p-dependent manner; has GRAM and StART-like (VASt) domains; one of six StART-like domain-containing proteins in yeast; conserved across eukaryotes; Belongs to the YSP2 family.


ensembl_gene_id: YLR073C
symbol: RFU1
gene_biotype: protein_coding
description:
  Regulator of free ubiquitin chains 1; Protein that inhibits Doa4p deubiquitinating activity; contributes to ubiquitin homeostasis by regulating the conversion of free ubiquitin chains to ubiquitin monomers by Doa4p; GFP-fusion protein localizes to endosomes.


ensembl_gene_id: YLR074C
symbol: BUD20
gene_biotype: protein_coding
description:
  Bud site selection protein 20; C2H2-type zinc finger protein required for ribosome assembly; shuttling factor which associates with pre-60S particles in the nucleus, accompanying them to the cytoplasm; cytoplasmic dissociation of Bud20p requires Drg1p; N-terminus harbors a nuclear localization signal (NLS) and a nuclear export signal (NES); cytoplasmic Bud20p is reimported by Kap123-dependent pathway; involved in bud-site selection; diploid mutants display a random budding pattern; similar to human ZNF593.


ensembl_gene_id: YLR075W
symbol: RPL10
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L10; homologous to mammalian ribosomal protein L10 and bacterial L16; responsible for joining the 40S and 60S subunits; regulates translation initiation; similar to members of the QM gene family; protein abundance increases under DNA replication stress; mutations in human homolog implicated in T-cell acute lymphoblastic leukemia and also autism spectrum disorders (ASD); human RPL10 can complement yeast null mutant.


ensembl_gene_id: YLR076C
symbol: YLR076C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YLR076C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPL10 which encodes the ribosomal protein L10.


ensembl_gene_id: YLR077W
symbol: FMP25
gene_biotype: protein_coding
description:
  Protein FMP25, mitochondrial; Protein required for assembly of respiratory complex III; mitochondrial inner membrane protein; required for an early step in assembly of respiratory complex III (cytochrome bc1 complex); mRNA is targeted to mitochondria.


ensembl_gene_id: YLR078C
symbol: BOS1
gene_biotype: protein_coding
description:
  Protein transport protein BOS1; v-SNARE (vesicle specific SNAP receptor); localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the Golgi; required for efficient nuclear fusion during mating.


ensembl_gene_id: YLR079W
symbol: SIC1
gene_biotype: protein_coding
description:
  Protein SIC1; Cyclin-dependent kinase inhibitor (CKI); inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; phosphorylated by Clb5/6-Cdk1 and Cln1/2-Cdk1 kinase which regulate timing of Sic1p degradation; phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover; functional homolog of mammalian Kip1.


ensembl_gene_id: YLR080W
symbol: EMP46
gene_biotype: protein_coding
description:
  Protein EMP46; Integral membrane component of ER-derived COPII-coated vesicles; functions in ER to Golgi transport; EMP46 has a paralog, EMP47, that arose from the whole genome duplication.


ensembl_gene_id: YLR081W
symbol: GAL2
gene_biotype: protein_coding
description:
  Galactose permease; required for utilization of galactose; also able to transport glucose; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.


ensembl_gene_id: YLR082C
symbol: SRL2
gene_biotype: protein_coding
description:
  Protein of unknown function; overexpression suppresses the lethality caused by a rad53 null mutation.


ensembl_gene_id: YLR083C
symbol: EMP70
gene_biotype: protein_coding
description:
  Transmembrane 9 superfamily member 1; Protein with a role in cellular adhesion and filamentous growth; also endosome-to-vacuole sorting; similar to Tmn3p; member of Transmembrane Nine family of proteins with 9 transmembrane segments; EMP70 has a paralog, TMN2, that arose from the whole genome duplication; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.


ensembl_gene_id: YLR084C
symbol: RAX2
gene_biotype: protein_coding
description:
  Bud site selection protein RAX2; N-glycosylated protein; involved in the maintenance of bud site selection during bipolar budding; localization requires Rax1p; RAX2 mRNA stability is regulated by Mpt5p.


ensembl_gene_id: YLR085C
symbol: ARP6
gene_biotype: protein_coding
description:
  Actin-like protein ARP6; Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A.


ensembl_gene_id: YLR086W
symbol: SMC4
gene_biotype: protein_coding
description:
  Structural maintenance of chromosomes protein 4; Subunit of the condensin complex; condensin reorganizes chromosomes during both mitosis and meiosis; forms a subcomplex with Smc2p that has ATP-hydrolyzing and DNA-binding activity, but other condensin subunits are required for chromatin binding; required for tRNA gene clustering at the nucleolus; potential Cdc28p substrate; Belongs to the SMC family. SMC4 subfamily.


ensembl_gene_id: YLR087C
symbol: CSF1
gene_biotype: protein_coding
description:
  Protein required for fermentation at low temperature; plays a role in the maturation of secretory proteins; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Belongs to the CSF1 family.


ensembl_gene_id: YLR088W
symbol: GAA1
gene_biotype: protein_coding
description:
  Subunit of the GPI:protein transamidase complex; removes the GPI-anchoring signal and attaches GPI (glycosylphosphatidylinositol) to proteins in the ER; human homolog GPAA1 can complement growth defects of yeast thermosensitive mutant at restrictive temperature.


ensembl_gene_id: YLR089C
symbol: ALT1
gene_biotype: protein_coding
description:
  Probable alanine aminotransferase, mitochondrial; Alanine transaminase (glutamic pyruvic transaminase); involved in alanine biosynthesis and catabolism; TOR1-independent role in determining chronological lifespan; expression is induced in the presence of alanine; repression is mediated by Nrg1p; ALT1 has a paralog, ALT2, that arose from the whole genome duplication; Alt2p is catalytically inactive; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.


ensembl_gene_id: YLR090W
symbol: XDJ1
gene_biotype: protein_coding
description:
  DnaJ protein homolog XDJ1; Chaperone with a role in facilitating mitochondrial protein import; ascomycete-specific member of the DnaJ-like family, closely related to Ydj1p; predicted to be C-terminally prenylated; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies.


ensembl_gene_id: YLR091W
symbol: GEP5
gene_biotype: protein_coding
description:
  Genetic interactor of prohibitin 5, mitochondrial; Protein of unknown function; required for mitochondrial genome maintenance; detected in highly purified mitochondria in high-throughput studies; null mutant has decreased levels of cardiolipin and phosphatidylethanolamine; Belongs to the GEP5 family.


ensembl_gene_id: YLR092W
symbol: SUL2
gene_biotype: protein_coding
description:
  High affinity sulfate permease; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates; Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.


ensembl_gene_id: YLR093C
symbol: NYV1
gene_biotype: protein_coding
description:
  v-SNARE component of the vacuolar SNARE complex; involved in vesicle fusion; inhibits ATP-dependent Ca(2+) transport activity of Pmc1p in the vacuolar membrane.


ensembl_gene_id: YLR095C
symbol: IOC2
gene_biotype: protein_coding
description:
  ISWI one complex protein 2; Subunit of the Isw1b complex; exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing; contains a PHD finger motif; other complex members are Isw1p and Ioc4p.


ensembl_gene_id: YLR096W
symbol: KIN2
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase KIN2; Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; KIN2 has a paralog, KIN1, that arose from the whole genome duplication; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.


ensembl_gene_id: YLR097C
symbol: HRT3
gene_biotype: protein_coding
description:
  F-box protein HRT3; Putative SCF-ubiquitin ligase F-box protein; based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies.


ensembl_gene_id: YLR098C
symbol: CHA4
gene_biotype: protein_coding
description:
  Activatory protein CHA4; DNA binding transcriptional activator; mediates serine/threonine activation of the catabolic L-serine (L-threonine) deaminase (CHA1); Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain.


ensembl_gene_id: YLR099C
symbol: ICT1
gene_biotype: protein_coding
description:
  1-acylglycerol-3-phosphate O-acyltransferase ICT1; Lysophosphatidic acid acyltransferase; responsible for enhanced phospholipid synthesis during organic solvent stress; null displays increased sensitivity to Calcofluor white; highly expressed during organic solvent stress; ICT1 has a paralog, ECM18, that arose from the whole genome duplication; human ABHD5 can complement ict1 null mutant; Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.


ensembl_gene_id: YLR099W-A
symbol: MIM2
gene_biotype: protein_coding
description:
  Mitochondrial protein required for outer membrane protein import; involved in import of the subset of proteins with multiple alpha-helical transmembrane segments, including Ugo1p, Tom20p, and Fzo1p; component of a large protein complex in the outer membrane that includes Mim1p; not essential in W303 strain background; Belongs to the MIM2 family.


ensembl_gene_id: YLR100W
symbol: ERG27
gene_biotype: protein_coding
description:
  3-keto sterol reductase; catalyzes the last of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants are sterol auxotrophs; mutation is functionally complemented by human HSD17B7; Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily.


ensembl_gene_id: YLR101C
symbol: YLR101C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YLR101C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF ERG27/YLR100W.


ensembl_gene_id: YLR103C
symbol: CDC45
gene_biotype: protein_coding
description:
  Cell division control protein 45; DNA replication initiation factor; recruited to MCM pre-RC complexes at replication origins; promotes release of MCM from Mcm10p, recruits elongation machinery; binds tightly to ssDNA, which disrupts interaction with the MCM helicase and stalls it during replication stress; mutants in human homolog may cause velocardiofacial and DiGeorge syndromes.


ensembl_gene_id: YLR104W
symbol: LCL2
gene_biotype: protein_coding
description:
  Long chronological lifespan protein 2; Putative protein of unknown function; mutant is deficient in cell wall mannosylphosphate and has long chronological lifespan; genetic interactions suggest a role in ER-associated protein degradation (ERAD); SWAT-GFP fusion protein localizes to the endoplasmic reticulum and vacuole, while mCherry fusion localizes to just the vacuole.


ensembl_gene_id: YLR105C
symbol: SEN2
gene_biotype: protein_coding
description:
  Subunit of the tRNA splicing endonuclease; tRNA splicing endonuclease (Sen complex) is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen complex also cleaves the CBP1 mRNA at the mitochondrial surface; Sen2p contains the active site for tRNA 5' splice site cleavage and has similarity to Sen34p and to Archaeal tRNA splicing endonuclease.


ensembl_gene_id: YLR106C
symbol: MDN1
gene_biotype: protein_coding
description:
  Midasin; Huge dynein-related AAA-type ATPase (midasin); forms extended pre-60S particle with the Rix1 complex (Rix1p-Ipi1p-Ipi3p); acts in removal of ribosomal biogenesis factors at successive steps of pre-60S assembly and export from nucleus.


ensembl_gene_id: YLR107W
symbol: REX3
gene_biotype: protein_coding
description:
  RNA exonuclease; required for maturation of the RNA component of RNase MRP; functions redundantly with Rnh70p and Rex2p in processing of U5 snRNA and RNase P RNA; member of RNase D family of exonucleases; Belongs to the REXO1/REXO3 family.


ensembl_gene_id: YLR108C
symbol: YLR108C
gene_biotype: protein_coding
description:
  BTB/POZ domain-containing protein YLR108C; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YLR108C is not an esssential gene; protein abundance increases in response to DNA replication stress; YLR108C has a paralog, YDR132C, that arose from the whole genome duplication.


ensembl_gene_id: YLR109W
symbol: AHP1
gene_biotype: protein_coding
description:
  Thiol-specific peroxiredoxin; reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p; Belongs to the peroxiredoxin family. Prx5 subfamily.


ensembl_gene_id: YLR110C
symbol: CCW12
gene_biotype: protein_coding
description:
  Cell wall mannoprotein; plays a role in maintenance of newly synthesized areas of cell wall; localizes to periphery of small buds, septum region of larger buds, and shmoo tip; CCW12 has a paralog, YDR134C, that arose from the whole genome duplication.


ensembl_gene_id: YLR111W
symbol: YLR111W
gene_biotype: protein_coding
description:
  Uncharacterized protein YLR111W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YLR112W
symbol: YLR112W
gene_biotype: protein_coding
description:
  Uncharacterized protein YLR112W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YLR113W
symbol: HOG1
gene_biotype: protein_coding
description:
  Mitogen-activated protein kinase involved in osmoregulation; controls global reallocation of RNAPII during osmotic shock; mediates recruitment/activation of RNAPII at Hot1p-dependent promoters; binds calmodulin; stimulates antisense transcription to activate CDC28; defines novel S-phase checkpoint with Mrc1p that prevent replication/transcription conflicts; nuclear form represses pseudohyphal growth; autophosphorylates; protein abundance increases under DNA replication stress; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily.


ensembl_gene_id: YLR114C
symbol: AVL9
gene_biotype: protein_coding
description:
  Late secretory pathway protein AVL9; Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress.


ensembl_gene_id: YLR115W
symbol: CFT2
gene_biotype: protein_coding
description:
  Cleavage factor two protein 2; Subunit of the mRNA cleavage and polyadenlylation factor (CPF); required for pre-mRNA cleavage, polyadenylation and poly(A) site recognition, 43% similarity with the mammalian CPSF-100 protein.


ensembl_gene_id: YLR116W
symbol: MSL5
gene_biotype: protein_coding
description:
  Branchpoint-bridging protein; Component of commitment complex; which defines first step in splicing pathway; essential protein that interacts with Mud2p and Prp40p, forming a bridge between the intron ends; also involved in nuclear retention of pre-mRNA; relocalizes to the cytosol in response to hypoxia.


ensembl_gene_id: YLR117C
symbol: CLF1
gene_biotype: protein_coding
description:
  Pre-mRNA-splicing factor CLF1; Member of the NineTeen Complex (NTC); this complex contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins.


ensembl_gene_id: YLR118C
symbol: YLR118C
gene_biotype: protein_coding
description:
  Acyl-protein thioesterase responsible for depalmitoylation of Gpa1p; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS; Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.


ensembl_gene_id: YLR119W
symbol: SRN2
gene_biotype: protein_coding
description:
  Protein SRN2; Component of the ESCRT-I complex; ESCRT-I is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus; Belongs to the VPS37 family.


ensembl_gene_id: YLR120C
symbol: YPS1
gene_biotype: protein_coding
description:
  Aspartic proteinase 3 subunit alpha; Aspartic protease; hyperglycosylated member of the yapsin family of proteases, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor; involved in nutrient limitation-induced cleavage of the extracellular inhibitory domain of signaling mucin Msb2p, resulting in activation of the filamentous growth MAPK pathway; involved with other yapsins in the cell wall integrity response; role in KEX2-independent processing of the alpha factor precursor.


ensembl_gene_id: YLR120W-A
symbol: YLR120W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YLR120W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR121C.


ensembl_gene_id: YLR121C
symbol: YPS3
gene_biotype: protein_coding
description:
  Aspartic proteinase yapsin-3; Aspartic protease; member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor; Belongs to the peptidase A1 family.


ensembl_gene_id: YLR122C
symbol: YLR122C
gene_biotype: protein_coding
description:
  Uncharacterized protein YLR122C; Putative protein of unknown function; conserved among S. cerevisiae strains; partially overlaps dubious ORF YLR123C.


ensembl_gene_id: YLR123C
symbol: YLR123C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YLR123C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif.


ensembl_gene_id: YLR124W
symbol: YLR124W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YLR124W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YLR125W
symbol: YLR125W
gene_biotype: protein_coding
description:
  Putative protein of unknown function; mutant has decreased Ty3 transposition; YLR125W is not an essential gene.


ensembl_gene_id: YLR126C
symbol: YLR126C
gene_biotype: protein_coding
description:
  Putative glutamine amidotransferase; has Aft1p-binding motif in the promoter; may be involved in copper and iron homeostasis; YLR126C is not an essential protein; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress.


ensembl_gene_id: YLR127C
symbol: APC2
gene_biotype: protein_coding
description:
  Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the catalytic core of the APC/C; has similarity to cullin Cdc53p.


ensembl_gene_id: YLR128W
symbol: DCN1
gene_biotype: protein_coding
description:
  Scaffold-type E3 ligase; required for cullin neddylation and ubiquitin ligase activation; contains a ubiquitin-binding domain (UBA) for ubiquitin and Nedd8 (Rub1p) interaction and a PONY domain involved in cullin binding and neddylation.


ensembl_gene_id: YLR129W
symbol: DIP2
gene_biotype: protein_coding
description:
  Nucleolar protein; specifically associated with the U3 snoRNA, part of the large ribonucleoprotein complex known as the small subunit (SSU) processome, required for 18S rRNA biogenesis, part of the active pre-rRNA processing complex.


ensembl_gene_id: YLR130C
symbol: ZRT2
gene_biotype: protein_coding
description:
  Zinc-regulated transporter 2; Low-affinity zinc transporter of the plasma membrane; transcription is induced under low-zinc conditions by the Zap1p transcription factor.


ensembl_gene_id: YLR131C
symbol: ACE2
gene_biotype: protein_coding
description:
  Metallothionein expression activator; Transcription factor required for septum destruction after cytokinesis; phosphorylation by Cbk1p blocks nuclear exit during M/G1 transition, causing localization to daughter cell nuclei, and also increases Ace2p activity; phosphorylation by Cdc28p and Pho85p prevents nuclear import during cell cycle phases other than cytokinesis; part of RAM network that regulates cellular polarity and morphogenesis; ACE2 has a paralog, SWI5, that arose from the whole genome duplication.


ensembl_gene_id: YLR132C
symbol: USB1
gene_biotype: protein_coding
description:
  U6 snRNA phosphodiesterase; Putative poly(U)-specific 3'-to-5' RNA exonuclease; involved in 3'-end processing of U6 snRNA removing uridines and generating a terminal 2&#8242;,3&#8242; cyclic phosphate; essential protein that localizes to the nucleus and mitochondria; overexpression suppresses the respiratory defects of oxa1 and mtf2 mutants; homolog of S.pombe gene, mpn1 and human gene, hUSB1; mutations in hUSB1 are associated with a rare genodermatosis, poikiloderma with neutropenia (OMIM 604173); Belongs to the 2H phosphoesterase superfamily. USB1 family.


ensembl_gene_id: YLR133W
symbol: CKI1
gene_biotype: protein_coding
description:
  Choline kinase; catalyzes the first step in phosphatidylcholine synthesis via the CDP-choline (Kennedy pathway); exhibits some ethanolamine kinase activity contributing to phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; CKI1 has a paralog, EKI1, that arose from the whole genome duplication.


ensembl_gene_id: YLR134W
symbol: PDC5
gene_biotype: protein_coding
description:
  Minor isoform of pyruvate decarboxylase; key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde, regulation is glucose- and ethanol-dependent, repressed by thiamine, involved in amino acid catabolism.


ensembl_gene_id: YLR135W
symbol: SLX4
gene_biotype: protein_coding
description:
  Structure-specific endonuclease subunit SLX4; Endonuclease involved in processing DNA; acts during recombination, repair; promotes template switching during break-induced replication (BIR), causing non-reciprocal translocations (NRTs); cleaves branched structures in complex with Slx1p; involved in interstrand cross-link repair, Rad1p/Rad10p-dependent removal of 3'-nonhomologous tails during DSBR via single-strand annealing; relative distribution to nuclear foci increases upon DNA replication stress; FANCP-related factor; Belongs to the SLX4 family.


ensembl_gene_id: YLR136C
symbol: TIS11
gene_biotype: protein_coding
description:
  mRNA decay factor CTH2; mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; TIS11 has a paralog, CTH1, that arose from the whole genome duplication.


ensembl_gene_id: YLR137W
symbol: RKM5
gene_biotype: protein_coding
description:
  Protein lysine methyltransferase; monomethylates Lys-46 of the ribosomal large subunit Rpl1a/Rpl1b; member of the seven beta-strand methyltransferase superfamily; orthologs only found among fungal species; Belongs to the class I-like SAM-binding methyltransferase superfamily. RKM5 family.


ensembl_gene_id: YLR138W
symbol: NHA1
gene_biotype: protein_coding
description:
  Na+/H+ antiporter; involved in sodium and potassium efflux through the plasma membrane; required for alkali cation tolerance at acidic pH.


ensembl_gene_id: YLR139C
symbol: SLS1
gene_biotype: protein_coding
description:
  Sigma-like sequence protein 1, mitochondrial; Mitochondrial membrane protein; coordinates expression of mitochondrially-encoded genes; may facilitate delivery of mRNA to membrane-bound translation machinery; Belongs to the SLS1 family.


ensembl_gene_id: YLR140W
symbol: YLR140W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YLR140W; Dubious open reading frame unlikely to encode a functional protein; overlaps essential RRN5 gene which encodes a member of the UAF transcription factor involved in transcription of rDNA by RNA polymerase I.


ensembl_gene_id: YLR141W
symbol: RRN5
gene_biotype: protein_coding
description:
  Protein involved in transcription of rDNA by RNA polymerase I; transcription factor, member of UAF (upstream activation factor) family along with Rrn9p and Rrn10p.


ensembl_gene_id: YLR142W
symbol: PUT1
gene_biotype: protein_coding
description:
  Proline oxidase; nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source.


ensembl_gene_id: YLR143W
symbol: DPH6
gene_biotype: protein_coding
description:
  Diphthine--ammonia ligase; Diphthamide synthetase; catalyzes the last amidation step of diphthamide biosynthesis using ammonium and ATP; evolutionarily conserved in eukaryotes; dph6 mutants exhibit diphthine accumulation and resistance to sordarin, which is indicative of defects in diphthamide formation on EF2; green fluorescent protein (GFP)-tagged protein localizes to the cytoplasm; DPH6/YLR143W is not an essential gene; In the C-terminal section; belongs to the RutC family.


ensembl_gene_id: YLR144C
symbol: ACF2
gene_biotype: protein_coding
description:
  Endo-1,3(4)-beta-glucanase 2; Intracellular beta-1,3-endoglucanase; expression is induced during sporulation; may have a role in cortical actin cytoskeleton assembly; protein abundance increases in response to DNA replication stress; Belongs to the glycosyl hydrolase 81 family.


ensembl_gene_id: YLR145W
symbol: RMP1
gene_biotype: protein_coding
description:
  Ribonuclease MRP protein subunit RMP1; Subunit of RNase MRP; RNase MRP processes pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; unlike most subunits, not shared between RNase MRP and nuclear RNase P.


ensembl_gene_id: YLR146C
symbol: SPE4
gene_biotype: protein_coding
description:
  Spermine synthase; required for the biosynthesis of spermine and also involved in biosynthesis of pantothenic acid.


ensembl_gene_id: YLR147C
symbol: SMD3
gene_biotype: protein_coding
description:
  Small nuclear ribonucleoprotein Sm D3; Core Sm protein Sm D3; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D3.


ensembl_gene_id: YLR148W
symbol: PEP3
gene_biotype: protein_coding
description:
  Component of CORVET membrane tethering complex; vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins, required for vacuolar biogenesis.


ensembl_gene_id: YLR149C
symbol: YLR149C
gene_biotype: protein_coding
description:
  Uncharacterized protein YLR149C; Protein of unknown function; overexpression causes a cell cycle delay or arrest; null mutation results in a decrease in plasma membrane electron transport; YLR149C is not an essential gene; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YLR149C-A
symbol: YLR149C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YLR149C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YLR150W
symbol: STM1
gene_biotype: protein_coding
description:
  Suppressor protein STM1; Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery.


ensembl_gene_id: YLR151C
symbol: PCD1
gene_biotype: protein_coding
description:
  Peroxisomal coenzyme A diphosphatase 1, peroxisomal; 8-oxo-dGTP diphosphatase; prevents spontaneous mutagenesis via sanitization of oxidized purine nucleoside triphosphates; can also act as peroxisomal pyrophosphatase with specificity for coenzyme A and CoA derivatives, may function to remove potentially toxic oxidized CoA disulfide from peroxisomes to maintain the capacity for beta-oxidation of fatty acids; nudix hydrolase family member; similar E. coli MutT and human, rat and mouse MTH1.


ensembl_gene_id: YLR152C
symbol: YLR152C
gene_biotype: protein_coding
description:
  Uncharacterized transporter YLR152C; Putative protein of unknown function; YLR152C is not an essential gene.


ensembl_gene_id: YLR153C
symbol: ACS2
gene_biotype: protein_coding
description:
  Acetyl-coA synthetase isoform; along with Acs1p, acetyl-coA synthetase isoform is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions; Belongs to the ATP-dependent AMP-binding enzyme family.


ensembl_gene_id: YLR154C
symbol: RNH203
gene_biotype: protein_coding
description:
  Ribonuclease H2 subunit; required for RNase H2 activity; role in ribonucleotide excision repair; related to human AGS3 that causes Aicardi-Goutieres syndrome.


ensembl_gene_id: YLR154C-G
symbol: YLR154C-G
gene_biotype: protein_coding
description:
  Uncharacterized protein YLR154C-G; Putative protein of unknown function; identified by fungal homology comparisons and RT-PCR; this ORF is contained within RDN25-2 and RDN37-2.


ensembl_gene_id: YLR154C-H
symbol: YLR154C-H
gene_biotype: protein_coding
description:
  Uncharacterized protein YLR157C-C; Putative protein of unknown function; identified by fungal homology comparisons and RT-PCR; this ORF partially overlaps RDN5-2; YLR154C-H has a paralog, YLR157C-C, that arose from a segmental duplication.


ensembl_gene_id: YLR154W-A
symbol: YLR154W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein ART2; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; encoded within the 25S rRNA gene on the opposite strand.


ensembl_gene_id: YLR154W-B
symbol: YLR154W-B
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YLR154W-B; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; encoded within the 25S rRNA gene on the opposite strand.


ensembl_gene_id: YLR154W-C
symbol: TAR1
gene_biotype: protein_coding
description:
  Protein potentially involved in regulation of respiratory metabolism; located in the mitochondria; interacts genetically with RPO41 and physically with Coq5p; encoded within the 25S rRNA gene on the opposite strand.


ensembl_gene_id: YLR154W-E
symbol: YLR154W-E
gene_biotype: protein_coding
description:
  Putative uncharacterized protein ART3; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; encoded within the 35S rRNA gene on the opposite strand.


ensembl_gene_id: YLR154W-F
symbol: YLR154W-F
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YLR154W-F; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; encoded within the 35S rRNA gene on the opposite strand.


ensembl_gene_id: YLR155C
symbol: ASP3-1
gene_biotype: protein_coding
description:
  Cell-wall L-asparaginase II involved in asparagine catabolism; expression induced during nitrogen starvation; ORF contains a short non-coding RNA that enhances expression of full-length gene; likely arose in via horizontal gene transfer from the wine yeast Wickerhamomyces anomalus or a close relative; reference strain S288C has four copies of ASP3; ASP3-1 has a paralog, ASP3-3, that arose from a segmental duplication.


ensembl_gene_id: YLR156C-A
symbol: YLR156C-A
gene_biotype: protein_coding
description:
  Putative protein of unknown function; identified by fungal homology comparisons and RT-PCR; partially overlaps RND5-3; YLR156C-A has a paralog, YLR159C-A, that arose from a segmental duplication.


ensembl_gene_id: YLR156W
symbol: YLR156W
gene_biotype: protein_coding
description:
  Putative protein of unknown function; exhibits a two-hybrid interaction with Jsn1p in a large-scale analysis; YLR156W has a paralog, YLR159W, that arose from a segmental duplication.


ensembl_gene_id: YLR157C
symbol: ASP3-2
gene_biotype: protein_coding
description:
  Cell-wall L-asparaginase II involved in asparagine catabolism; expression induced during nitrogen starvation; ORF contains a short non-coding RNA that enhances expression of full-length gene; likely arose in via horizontal gene transfer from the wine yeast Wickerhamomyces anomalus or a close relative; reference strain S288C has four copies of ASP3; ASP3-2 has a paralog, ASP3-4, that arose from a segmental duplication.


ensembl_gene_id: YLR157C-C
symbol: YLR157C-C
gene_biotype: protein_coding
description:
  Putative protein of unknown function; identified by fungal homology comparisons and RT-PCR; this ORF partially overlaps RDN5-4; YLR157C-C has a paralog, YLR154C-H, that arose from a segmental duplication.


ensembl_gene_id: YLR157W-D
symbol: YLR157W-D
gene_biotype: protein_coding
description:
  Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; YLR157W-D has a paralog, YLR161W, that arose from a segmental duplication.


ensembl_gene_id: YLR157W-E
symbol: YLR157W-E
gene_biotype: protein_coding
description:
  Putative protein of unknown function identified by gene-trapping; microarray-based expression analysis, and genome-wide homology searching; partially overlaps a Ty1 element.


ensembl_gene_id: YLR158C
symbol: ASP3-3
gene_biotype: protein_coding
description:
  Cell-wall L-asparaginase II involved in asparagine catabolism; expression induced during nitrogen starvation; ORF contains a short non-coding RNA that enhances expression of full-length gene; likely arose in via horizontal gene transfer from the wine yeast Wickerhamomyces anomalus or a close relative; reference strain S288C has four copies of ASP3; ASP3-3 has a paralog, ASP3-1, that arose from a segmental duplication.


ensembl_gene_id: YLR159C-A
symbol: YLR159C-A
gene_biotype: protein_coding
description:
  Putative protein of unknown function; identified by fungal homology comparisons and RT-PCR; partially overlaps RND5-5; YLR159C-A has a paralog, YLR156C-A, that arose from a segmental duplication.


ensembl_gene_id: YLR159W
symbol: YLR159W
gene_biotype: protein_coding
description:
  Putative protein of unknown function; YLR156W, YLR159W, and YLR161W are three identical open reading frames in S288C encoded near the ribosomal DNA region of chromosome 12; YLR159W has a paralog, YLR156W, that arose from a segmental duplication.


ensembl_gene_id: YLR160C
symbol: ASP3-4
gene_biotype: protein_coding
description:
  Cell-wall L-asparaginase II involved in asparagine catabolism; expression induced during nitrogen starvation; ORF contains a short non-coding RNA that enhances expression of full-length gene; likely arose in via horizontal gene transfer from the wine yeast Wickerhamomyces anomalus or a close relative; reference strain S288C has four copies of ASP3; ASP3-4 has a paralog, ASP3-2, that arose from a segmental duplication.


ensembl_gene_id: YLR161W
symbol: YLR161W
gene_biotype: protein_coding
description:
  Putative protein of unknown function; YLR156W, YLR159W, and YLR161W are three identical open reading frames in S288C encoded near the ribosomal DNA region of chromosome 12; YLR161W has a paralog, YLR157W-D, that arose from a segmental duplication.


ensembl_gene_id: YLR162W
symbol: YLR162W
gene_biotype: protein_coding
description:
  Protein of unknown function; overexpression confers resistance to the antimicrobial peptide MiAMP1 and causes growth arrest, apoptosis, and increased sensitivity to cobalt chloride.


ensembl_gene_id: YLR162W-A
symbol: RRT15
gene_biotype: protein_coding
description:
  Regulator of rDNA transcription protein 15; Putative protein of unknown function; identified by fungal homology comparisons and RT-PCR; identified in a screen for mutants with decreased levels of rDNA transcription.


ensembl_gene_id: YLR163C
symbol: MAS1
gene_biotype: protein_coding
description:
  Beta subunit of the mitochondrial processing protease (MPP); essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins; Belongs to the peptidase M16 family.


ensembl_gene_id: YLR163W-A
symbol: YLR163W-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YLR163W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YLR164W
symbol: SHH4
gene_biotype: protein_coding
description:
  Mitochondrial inner membrane protein SHH4; Putative alternate subunit of succinate dehydrogenase (SDH); mitochondrial inner membrane protein; genetic interaction with SDH4 suggests that Shh4p can function as a functional SDH subunit; a fraction copurifies with SDH subunit Sdh3p; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner; Shh4p has greater similarity to human SDHD (subunit D of SDH, implicated in paraganglioma) than does its paralog Sdh4p; Belongs to the CybS family.


ensembl_gene_id: YLR165C
symbol: PUS5
gene_biotype: protein_coding
description:
  21S rRNA pseudouridine(2819) synthase; Pseudouridine synthase; catalyzes only the formation of pseudouridine (Psi)-2819 in mitochondrial 21S rRNA; not essential for viability.


ensembl_gene_id: YLR166C
symbol: SEC10
gene_biotype: protein_coding
description:
  Essential 100kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; Belongs to the SEC10 family.


ensembl_gene_id: YLR167W
symbol: RPS31
gene_biotype: protein_coding
description:
  Fusion protein cleaved to yield ribosomal protein S31 and ubiquitin; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; interacts genetically with translation factor eIF2B; homologous to mammalian ribosomal protein S27A, no bacterial homolog.


ensembl_gene_id: YLR168C
symbol: UPS2
gene_biotype: protein_coding
description:
  Mitochondrial intermembrane space protein; involved in phospholipid metabolism; forms complex with Mdm35p that transfers phosphatidylserine from outer membrane to inner membrane for phosphatidylethanolamine synthesis; null mutant has defects in mitochondrial morphology; similar to Ups1p, Ups3p and to human PRELI; UPS2 has a paralog, UPS3, that arose from the whole genome duplication; Belongs to the slowmo family.


ensembl_gene_id: YLR169W
symbol: YLR169W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YLR169W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YLR170C
symbol: APS1
gene_biotype: protein_coding
description:
  Small subunit of the clathrin-associated adaptor complex AP-1; AP-1 is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex.


ensembl_gene_id: YLR171W
symbol: YLR171W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YLR171W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YLR172C
symbol: DPH5
gene_biotype: protein_coding
description:
  Diphthine methyl ester synthase; Methyltransferase required for synthesis of diphthamide; diphthamide is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); not essential for viability; GFP-Dph5p fusion protein localizes to the cytoplasm; Belongs to the diphthine synthase family.


ensembl_gene_id: YLR174W
symbol: IDP2
gene_biotype: protein_coding
description:
  Cytosolic NADP-specific isocitrate dehydrogenase; catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose; IDP2 has a paralog, IDP3, that arose from the whole genome duplication.


ensembl_gene_id: YLR175W
symbol: CBF5
gene_biotype: protein_coding
description:
  H/ACA ribonucleoprotein complex subunit CBF5; Pseudouridine synthase catalytic subunit of box H/ACA snoRNPs; acts on large and small rRNAs, on snRNA U2, and on some mRNAs; mutations in human ortholog dyskerin cause the disorder dyskeratosis congenita; small nucleolar ribonucleoprotein particles are also known as snoRNPs.


ensembl_gene_id: YLR176C
symbol: RFX1
gene_biotype: protein_coding
description:
  RFX-like DNA-binding protein RFX1; Major transcriptional repressor of DNA-damage-regulated genes; recruits repressors Tup1p and Cyc8p to their promoters; involved in DNA damage and replication checkpoint pathway; similar to a family of mammalian DNA binding RFX1-4 proteins.


ensembl_gene_id: YLR177W
symbol: YLR177W
gene_biotype: protein_coding
description:
  Uncharacterized protein YLR177W; Putative protein of unknown function; phosphorylated by Dbf2p-Mob1p in vitro; some strains contain microsatellite polymophisms at this locus; not an essential gene; YLR177W has a paralog, PSP1, that arose from the whole genome duplication; Belongs to the PSP1 family.


ensembl_gene_id: YLR178C
symbol: TFS1
gene_biotype: protein_coding
description:
  Inhibitor of carboxypeptidase Y (Prc1p), and Ras GAP (Ira2p); phosphatidylethanolamine-binding protein (PEBP) family member and ortholog of hPEBP1/RKIP, a natural metastasis suppressor; targets to vacuolar membranes during stationary phase; acetylated by NatB N-terminal acetyltransferase; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YLR179C
symbol: YLR179C
gene_biotype: protein_coding
description:
  Uncharacterized protein YLR179C; Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus.


ensembl_gene_id: YLR180W
symbol: SAM1
gene_biotype: protein_coding
description:
  S-adenosylmethionine synthase 1; S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; SAM1 has a paralog, SAM2, that arose from the whole genome duplication.


ensembl_gene_id: YLR181C
symbol: VTA1
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein VTA1; Multivesicular body (MVB) protein; involved in endosomal protein sorting; regulates Vps4p activity by promoting its oligomerization; has an N-terminal Vps60- and Did2- binding domain, a linker region, and a C-terminal Vps4p binding domain.


ensembl_gene_id: YLR182W
symbol: SWI6
gene_biotype: protein_coding
description:
  Regulatory protein SWI6; Transcription cofactor; forms complexes with Swi4p and Mbp1p to regulate transcription at the G1/S transition; involved in meiotic gene expression; also binds Stb1p to regulate transcription at START; cell wall stress induces phosphorylation by Mpk1p, which regulates Swi6p localization; required for the unfolded protein response, independently of its known transcriptional coactivators.


ensembl_gene_id: YLR183C
symbol: TOS4
gene_biotype: protein_coding
description:
  Protein TOS4; Putative transcription factor, contains Forkhead Associated domain; binds chromatin; involved in expression homeostasis, buffering of mRNA synthesis rate against gene dosage changes during S phase; target of SBF transcription factor; expression is periodic and peaks in G1; involved in DNA replication checkpoint response; interacts with Rpd3 and Set3 histone deacetylase complexes; APCC(Cdh1) substrate; relative distribution to nucleus increases upon DNA replication stress.


ensembl_gene_id: YLR184W
symbol: YLR184W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YLR184W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YLR185W
symbol: RPL37A
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L37A; required for processing of 27SB pre-rRNA and formation of stable 66S assembly intermediates; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37A has a paralog, RPL37B, that arose from the whole genome duplication.


ensembl_gene_id: YLR186W
symbol: EMG1
gene_biotype: protein_coding
description:
  Ribosomal RNA small subunit methyltransferase NEP1; Methyltransferase for rRNA; methylates pseudouridine 18S rRNA residue 1191; member of the SPOUT methyltransferase family; required for maturation of 18S rRNA and for 40S ribosomal subunit production independent of methyltransferase activity; forms homodimers; human ortholog is mutated in Bowen-Conradi syndrome, and equivalent yeast mutation affects Emg1p dimerization and localization but not methyltransferase activity; human EMG1 complements lethality of null and ts mutant; Belongs to the class IV-like SAM-binding methyltransferase su [...]


ensembl_gene_id: YLR187W
symbol: SKG3
gene_biotype: protein_coding
description:
  Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; potential Cdc28p substrate; similar to Skg4p; relocalizes from bud neck to cytoplasm upon DNA replication stress; SKG3 has a paralog, CAF120, that arose from the whole genome duplication.


ensembl_gene_id: YLR188W
symbol: MDL1
gene_biotype: protein_coding
description:
  ATP-dependent permease MDL1, mitochondrial; Mitochondrial inner membrane half-type ABC transporter; mediates export of peptides generated upon proteolysis of mitochondrial proteins; plays a role in the regulation of cellular resistance to oxidative stress.


ensembl_gene_id: YLR189C
symbol: ATG26
gene_biotype: protein_coding
description:
  UDP-glucose:sterol glucosyltransferase; conserved enzyme involved in synthesis of sterol glucoside membrane lipids; in contrast to ATG26 from P. pastoris, S. cerevisiae ATG26 is not involved in autophagy; Belongs to the glycosyltransferase 28 family.


ensembl_gene_id: YLR190W
symbol: MMR1
gene_biotype: protein_coding
description:
  Mitochondrial MYO2 receptor-related protein 1; Phosphorylated protein of the mitochondrial outer membrane; localizes only to mitochondria of the bud; interacts with Myo2p to mediate mitochondrial distribution to buds; mRNA is targeted to the bud via the transport system involving She2p.


ensembl_gene_id: YLR191W
symbol: PEX13
gene_biotype: protein_coding
description:
  Peroxisomal membrane protein PAS20; Peroxisomal importomer complex component; integral peroxisomal membrane protein required for docking and translocation of peroxisomal matrix proteins; interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p; forms a complex with Pex14p and Pex17p; human homolog PEX13 complements yeast null mutant; Belongs to the peroxin-13 family.


ensembl_gene_id: YLR192C
symbol: HCR1
gene_biotype: protein_coding
description:
  eIF3j component of translation initiation factor 3 (eIF3); dual function protein involved in translation initiation as a substoichiometric component (eIF3j) of eIF3; required for 20S pre-rRNA processing; required at post-transcriptional step for efficient retrotransposition; absence decreases Ty1 Gag:GFP protein levels; binds eIF3 subunits Rpg1p, Prt1p and 18S rRNA; eIF3 also involved in programmed stop codon read through; human homolog EIF3J can complement yeast hcr1 mutant; Belongs to the eIF-3 subunit J family.


ensembl_gene_id: YLR193C
symbol: UPS1
gene_biotype: protein_coding
description:
  Protein UPS1, mitochondrial; Phosphatidic acid transfer protein; plays a role in phospholipid metabolism by transporting phosphatidic acid from the outer to the inner mitochondrial membrane; localizes to the mitochondrial intermembrane space; null mutant has altered cardiolipin and phosphatidic acid levels; ortholog of human PRELI; Belongs to the slowmo family.


ensembl_gene_id: YLR194C
symbol: NCW2
gene_biotype: protein_coding
description:
  Cell wall biogenesis protein NCW2; Structural constituent of the cell wall; attached to the plasma membrane by a GPI-anchor; expression is upregulated in response to cell wall stress; null mutant is sensitive to the antifungal agent polyhexamethylene biguanide, resistant to zymolyase treatment and has increased chitin deposition.


ensembl_gene_id: YLR195C
symbol: NMT1
gene_biotype: protein_coding
description:
  Glycylpeptide N-tetradecanoyltransferase; N-myristoyl transferase; catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction; Belongs to the NMT family.


ensembl_gene_id: YLR196W
symbol: PWP1
gene_biotype: protein_coding
description:
  Periodic tryptophan protein 1; Protein with WD-40 repeats involved in rRNA processing; associates with trans-acting ribosome biogenesis factors; similar to beta-transducin superfamily; Belongs to the WD repeat PWP1 family.


ensembl_gene_id: YLR197W
symbol: NOP56
gene_biotype: protein_coding
description:
  Nucleolar protein 56; Essential evolutionarily-conserved nucleolar protein; component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects.


ensembl_gene_id: YLR198C
symbol: YLR198C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YLR198C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene SIK1/YLR197W.


ensembl_gene_id: YLR199C
symbol: PBA1
gene_biotype: protein_coding
description:
  Proteasome chaperone 1; Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; interaction with Pba1p-Add66p may affect function of the mature proteasome and its role in maintaining respiratory metabolism; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly; Belongs to the PSMG1 family.


ensembl_gene_id: YLR200W
symbol: YKE2
gene_biotype: protein_coding
description:
  Prefoldin subunit 6; Subunit of the heterohexameric Gim/prefoldin protein complex; involved in the folding of alpha-tubulin, beta-tubulin, and actin; prefoldin complex also localizes to chromatin of actively transcribed genes in the nucleus and facilitates transcriptional elongation.


ensembl_gene_id: YLR201C
symbol: COQ9
gene_biotype: protein_coding
description:
  Protein required for ubiquinone biosynthesis and respiratory growth; localizes to matrix face of mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; ubiquinone is also known as coenzyme Q; human homolog COQ9 can complement yeast coq9 null mutant.


ensembl_gene_id: YLR202C
symbol: YLR202C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YLR202C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR201C; ORF contains a putative intron.


ensembl_gene_id: YLR203C
symbol: MSS51
gene_biotype: protein_coding
description:
  Protein MSS51, mitochondrial; Specific translational activator for the mitochondrial COX1 mRNA; loosely associated with the matrix face of the mitochondrial inner membrane; localizes to vacuole membrane in response to H2O2; influences both COX1 mRNA translation and Cox1p assembly into cytochrome c oxidase; binds to heme B, which may be a mechanism for sensing oxygen levels in order to regulate cytochrome c oxidase biogenesis.


ensembl_gene_id: YLR204W
symbol: QRI5
gene_biotype: protein_coding
description:
  Mitochondrial inner membrane protein; required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA.


ensembl_gene_id: YLR205C
symbol: HMX1
gene_biotype: protein_coding
description:
  Heme-binding protein HMX1; ER localized heme oxygenase; involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants.


ensembl_gene_id: YLR206W
symbol: ENT2
gene_biotype: protein_coding
description:
  Epsin-2; Epsin-like protein required for endocytosis and actin patch assembly; functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus; ENT2 has a paralog, ENT1, that arose from the whole genome duplication.


ensembl_gene_id: YLR207W
symbol: HRD3
gene_biotype: protein_coding
description:
  ERAD-associated E3 ubiquitin-protein ligase component HRD3; ER membrane protein that plays a central role in ERAD; forms HRD complex with Hrd1p and ER-associated protein degradation (ERAD) determinants that engages in lumen to cytosol communication and coordination of ERAD events; Belongs to the sel-1 family.


ensembl_gene_id: YLR208W
symbol: SEC13
gene_biotype: protein_coding
description:
  Protein transport protein SEC13; Structural component of 3 complexes; subunit of the Nup84p nuclear pore subcomplex that contributes to nucleocytoplasmic transport and NPC biogenesis; subunit of the COPII vesicle coat required for ER-to-Golgi transport; subunit of SEACAT, a subcomplex of the coatomer-related, vacuolar-associated SEA complex, that inhibits the TORC1 inhibitory role of SEACIT (Iml1p-Npr2p-Npr3p), a GAP for Gtr1p, thereby resulting in activation of TORC1 signaling; human SEC13 homolog.


ensembl_gene_id: YLR209C
symbol: PNP1
gene_biotype: protein_coding
description:
  Purine nucleoside phosphorylase; specifically metabolizes inosine and guanosine nucleosides; involved in the nicotinamide riboside salvage pathway; Belongs to the PNP/MTAP phosphorylase family.


ensembl_gene_id: YLR210W
symbol: CLB4
gene_biotype: protein_coding
description:
  G2/mitotic-specific cyclin-4; B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation; CLB4 has a paralog, CLB3, that arose from the whole genome duplication.


ensembl_gene_id: YLR211C
symbol: ATG38
gene_biotype: protein_coding
description:
  Autophagy-related protein 38; Homodimeric subunit of autophagy-specific PtdIns-3-kinase complex I; required for the integrity of the active PtdIns-3-kinase complex I by maintaining an association between Vps15p-Vps34p and Atg14p-Vps30p subcomplexes; localizes to the pre-autophagosomal structure (PAS) in an Atg14p-dependent manner; ATG38 is non-essential but is required for macroautophagy.


ensembl_gene_id: YLR212C
symbol: TUB4
gene_biotype: protein_coding
description:
  Gamma-tubulin; involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YLR213C
symbol: CRR1
gene_biotype: protein_coding
description:
  Probable glycosidase CRR1; Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulation; Belongs to the glycosyl hydrolase 16 family. CRR1 subfamily.


ensembl_gene_id: YLR214W
symbol: FRE1
gene_biotype: protein_coding
description:
  Ferric/cupric reductase transmembrane component 1; Ferric reductase and cupric reductase; reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low copper and iron levels.


ensembl_gene_id: YLR215C
symbol: CDC123
gene_biotype: protein_coding
description:
  Cell division cycle protein 123; Assembly factor for the eIF2 translation initiation factor complex; regulates translational initiation; conserved residues of this ATP-Grasp protein that bind to ATP-Mg2+ in the pombe ortholog are required for complex assembly in budding yeast; interaction with eIF2 subunit Gcd11p facilitates complex assembly and activity; required for the START transition and timely progression through G2; regulated by nutrient availability; human ortholog complements the yeast mutant.


ensembl_gene_id: YLR216C
symbol: CPR6
gene_biotype: protein_coding
description:
  Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; plays a role in determining prion variants; binds to Hsp82p and contributes to chaperone activity; protein abundance increases in response to DNA replication stress; Belongs to the cyclophilin-type PPIase family. PPIase D subfamily.


ensembl_gene_id: YLR217W
symbol: YLR217W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YLR217W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CPR6.


ensembl_gene_id: YLR218C
symbol: COA4
gene_biotype: protein_coding
description:
  Cytochrome oxidase assembly factor 4; Twin Cx(9)C protein involved in cytochrome c oxidase organization; organization includes assembly or stability; localizes to the mitochondrial intermembrane space via the Mia40p-Erv1p system; interacts genetically with CYC1 and with cytochrome c oxidase assembly factors; Belongs to the COA4 family.


ensembl_gene_id: YLR219W
symbol: MSC3
gene_biotype: protein_coding
description:
  Meiotic sister-chromatid recombination protein 3; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; msc3 mutants are defective in directing meiotic recombination events to homologous chromatids; potential Cdc28p substrate; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YLR220W
symbol: CCC1
gene_biotype: protein_coding
description:
  Protein CCC1; Vacuolar Fe2+/Mn2+ transporter; suppresses respiratory deficit of yfh1 mutants, which lack the ortholog of mammalian frataxin, by preventing mitochondrial iron accumulation; relative distribution to the vacuole decreases upon DNA replication stress.


ensembl_gene_id: YLR221C
symbol: RSA3
gene_biotype: protein_coding
description:
  Ribosome assembly protein 3; Protein with a likely role in ribosomal maturation; required for accumulation of wild-type levels of large (60S) ribosomal subunits; binds to the helicase Dbp6p in pre-60S ribosomal particles in the nucleolus.


ensembl_gene_id: YLR222C-A
symbol: YLR222C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YLR222C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene IFH1.


ensembl_gene_id: YLR223C
symbol: IFH1
gene_biotype: protein_coding
description:
  Protein IFH1; Coactivator, regulates transcription of ribosomal protein (RP) genes; recruited to RP gene promoters during optimal growth conditions via Fhl1p; subunit of CURI, a complex that coordinates RP production and pre-rRNA processing; regulated by acetylation and phosphorylation at different growth states via TORC1 signaling; IFH1 has a paralog, CRF1, that arose from the whole genome duplication.


ensembl_gene_id: YLR224W
symbol: UCC1
gene_biotype: protein_coding
description:
  F-box protein and component of SCF ubiquitin ligase complexes; involved in ubiquitin-dependent protein catabolism; readily monoubiquitinated in vitro by SCF-Ubc4 complexes; SCF-Ucc1 regulates level of Cit2 citrate synthase protein to maintain citrate homeostasis, acts as metabolic switch for glyoxylate cycle; UCC1 transcription is downregulated in cells grown on C2-compounds.


ensembl_gene_id: YLR225C
symbol: YLR225C
gene_biotype: protein_coding
description:
  Uncharacterized SVF1-like protein YLR225C; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; not an essential gene; YLR225C has a paralog, YDR222W, that arose from the whole genome duplication; Belongs to the SVF1 family.


ensembl_gene_id: YLR226W
symbol: BUR2
gene_biotype: protein_coding
description:
  Protein BUR2; Cyclin for the Sgv1p (Bur1p) protein kinase; Sgv1p and Bur2p comprise the CDK-cyclin BUR kinase complex which is involved in transcriptional regulation through its phosphorylation of the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II (Rpo21p); BUR kinase is also involved in the recruitment of Spt6p to the CTD at the onset of transcription.


ensembl_gene_id: YLR227C
symbol: ADY4
gene_biotype: protein_coding
description:
  Accumulates dyads protein 4; Structural component of the meiotic outer plaque; outer plaque is a membrane-organizing center that assembles on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane.


ensembl_gene_id: YLR228C
symbol: ECM22
gene_biotype: protein_coding
description:
  Sterol regulatory element binding protein; regulates transcription of sterol biosynthetic genes upon sterol depletion, after relocating from intracellular membranes to perinuclear foci; redundant activator of filamentation with UPC2, up-regulating the expression of genes involved in filamentous growth; contains Zn[2]-Cys[6] binuclear cluster; ECM22 has a paralog, UPC2, that arose from the whole genome duplication.


ensembl_gene_id: YLR229C
symbol: CDC42
gene_biotype: protein_coding
description:
  Cell division control protein 42; Small rho-like GTPase; essential for establishment and maintenance of cell polarity; plays a role late in cell fusion via activation of key cell fusion regulator Fus2p; mutants have defects in the organization of actin and septins; human homolog CDC42 can complement yeast cdc42 mutant.


ensembl_gene_id: YLR230W
symbol: YLR230W
gene_biotype: protein_coding
description:
  Putative uncharacterized membrane protein YLR230W; Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential CDC42/YLR229C gene which encodes a small Rho-like GTPase essential for establishment and maintenance of cell polarity.


ensembl_gene_id: YLR231C
symbol: BNA5
gene_biotype: protein_coding
description:
  Kynureninase; required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p.


ensembl_gene_id: YLR232W
symbol: YLR232W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YLR232W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene BNA5.


ensembl_gene_id: YLR233C
symbol: EST1
gene_biotype: protein_coding
description:
  Telomere elongation protein EST1; TLC1 RNA-associated factor involved in telomere length regulation; recruitment subunit of telomerase; has G-quadruplex promoting activity required for telomere elongation; role in activating telomere-bound Est2p-TLC1-RNA; EST1 has a paralog, EBS1, that arose from the whole genome duplication.


ensembl_gene_id: YLR234W
symbol: TOP3
gene_biotype: protein_coding
description:
  DNA Topoisomerase III; conserved protein that functions in a complex with Sgs1p and Rmi1p to relax single-stranded negatively-supercoiled DNA preferentially; DNA catenation/decatenation activity is stimulated by RPA and Sgs1p-Top3p-Rmi1p; involved in telomere stability and regulation of mitotic recombination.


ensembl_gene_id: YLR235C
symbol: YLR235C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YLR235C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORFs TOP3/YLR234W and YLR236C.


ensembl_gene_id: YLR236C
symbol: YLR236C
gene_biotype: protein_coding
description:
  Uncharacterized protein YLR236C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF YLR235C.


ensembl_gene_id: YLR237W
symbol: THI7
gene_biotype: protein_coding
description:
  Plasma membrane transporter responsible for the uptake of thiamine; contributes to uptake of 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (acadesine); member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia.


ensembl_gene_id: YLR238W
symbol: FAR10
gene_biotype: protein_coding
description:
  Protein involved in recovery from arrest in response to pheromone; acts in a cell cycle arrest recovery pathway independent from Far1p; interacts with Far3p, Far7p, Far8p, Far9p, and Far11p; potential Cdc28p substrate; FAR10 has a paralog, VPS64, that arose from the whole genome duplication.


ensembl_gene_id: YLR239C
symbol: LIP2
gene_biotype: protein_coding
description:
  Lipoyl ligase; involved in the modification of mitochondrial enzymes by the attachment of lipoic acid groups; Belongs to the LipB family.


ensembl_gene_id: YLR240W
symbol: VPS34
gene_biotype: protein_coding
description:
  Phosphatidylinositol (PI) 3-kinase that synthesizes PI-3-phosphate; forms membrane-associated signal transduction complex with Vps15p to regulate protein sorting; activated by the GTP-bound form of Gpa1p; a fraction is localized, with Vps15p, to nuclear pores at nucleus-vacuole junctions and may facilitate transcription elongation for genes positioned at the nuclear periphery; Belongs to the PI3/PI4-kinase family.


ensembl_gene_id: YLR241W
symbol: CSC1
gene_biotype: protein_coding
description:
  Calcium permeable gated cation channel; may be involved in detoxification; similar to Arabidopsis CSC1.


ensembl_gene_id: YLR242C
symbol: ARV1
gene_biotype: protein_coding
description:
  Cortical ER protein; implicated in the membrane insertion of tail-anchored C-terminal single transmembrane domain proteins; may function in transport of glycosylphosphatidylinositol intermediates into the ER lumen; required for normal intracellular sterol distribution; human ARV1, required for normal cholesterol and bile acid homeostasis, can complement yeast arv1 null mutant; human variant causing early onset epileptic encephalopathy is unable to rescue the yeast null.


ensembl_gene_id: YLR243W
symbol: GPN3
gene_biotype: protein_coding
description:
  GPN-loop GTPase 3; Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; may have a role in sister chromatid cohesion; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn2p.


ensembl_gene_id: YLR244C
symbol: MAP1
gene_biotype: protein_coding
description:
  Methionine aminopeptidase; catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map2p; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.


ensembl_gene_id: YLR245C
symbol: CDD1
gene_biotype: protein_coding
description:
  Cytidine deaminase; catalyzes the modification of cytidine to uridine in vitro but native RNA substrates have not been identified, localizes to both the nucleus and cytoplasm.


ensembl_gene_id: YLR246W
symbol: ERF2
gene_biotype: protein_coding
description:
  Subunit of a palmitoyltransferase; this complex adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; mutants partially mislocalize Ras2p to the vacuole; palmitoyltransferase is composed of Erf2p and Shr5p.


ensembl_gene_id: YLR247C
symbol: IRC20
gene_biotype: protein_coding
description:
  Uncharacterized ATP-dependent helicase IRC20; E3 ubiquitin ligase and putative helicase; involved in synthesis-dependent strand annealing-mediated homologous recombination; ensures precise end-joining along with Srs2p in the Yku70p/Yku80p/Lig4p-dependent nonhomologous end joining (NHEJ) pathway; localizes to both the mitochondrion and the nucleus; contains a Snf2/Swi2 family ATPase/helicase and a RING finger domain; interacts with Cdc48p and Smt3p; null mutant displays increased levels of spontaneous Rad52p foci.


ensembl_gene_id: YLR248W
symbol: RCK2
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase RCK2; Protein kinase involved in response to oxidative and osmotic stress; identified as suppressor of S. pombe cell cycle checkpoint mutations; similar to CaM (calmodulin) kinases; RCK2 has a paralog, RCK1, that arose from the whole genome duplication; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.


ensembl_gene_id: YLR249W
symbol: YEF3
gene_biotype: protein_coding
description:
  Translation elongation factor 3; contains two ABC cassettes; binds and hydrolyzes ATP; YEF3 has a paralog, HEF3, that arose from the whole genome duplication; Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.


ensembl_gene_id: YLR250W
symbol: SSP120
gene_biotype: protein_coding
description:
  Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern.


ensembl_gene_id: YLR251W
symbol: SYM1
gene_biotype: protein_coding
description:
  Protein required for ethanol metabolism; induced by heat shock and localized to the inner mitochondrial membrane; homologous to mammalian peroxisomal membrane protein Mpv17; human homolog MPV17 is implicated in hepatocerebral mtDNA depletion syndromes (MDDS), and complements yeast null mutant.


ensembl_gene_id: YLR252W
symbol: YLR252W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YLR252W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SYM1, a mitochondrial protein involved in ethanol metabolism.


ensembl_gene_id: YLR253W
symbol: MCP2
gene_biotype: protein_coding
description:
  ABC1 family protein MCP2; Mitochondrial protein of unknown function involved in lipid homeostasis; associates with mitochondrial ribosome; integral membrane protein that localizes to the mitochondrial inner membrane; involved in mitochondrial morphology; non-essential gene which interacts genetically with MDM10, and other members of the ERMES complex; transcription is periodic during the metabolic cycle; homologous to human aarF domain containing kinase, ADCK1.


ensembl_gene_id: YLR254C
symbol: NDL1
gene_biotype: protein_coding
description:
  Homolog of nuclear distribution factor NudE; NUDEL; interacts with Pac1p and regulates dynein targeting to microtubule plus ends.


ensembl_gene_id: YLR255C
symbol: YLR255C
gene_biotype: protein_coding
description:
  Uncharacterized protein YLR255C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YLR256W
symbol: HAP1
gene_biotype: protein_coding
description:
  Zinc finger transcription factor; involved in the complex regulation of gene expression in response to levels of heme and oxygen; localizes to the mitochondrion as well as to the nucleus; the S288C sequence differs from other strain backgrounds due to a Ty1 insertion in the carboxy terminus.


ensembl_gene_id: YLR257W
symbol: YLR257W
gene_biotype: protein_coding
description:
  Uncharacterized protein YLR257W; Protein of unknown function; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YLR258W
symbol: GSY2
gene_biotype: protein_coding
description:
  Glycogen [starch] synthase isoform 2; Glycogen synthase; expression induced by glucose limitation, nitrogen starvation, heat shock, and stationary phase; activity regulated by cAMP-dependent, Snf1p and Pho85p kinases as well as by the Gac1p-Glc7p phosphatase; GSY2 has a paralog, GSY1, that arose from the whole genome duplication; relocalizes from cytoplasm to plasma membrane upon DNA replication stress; Belongs to the glycosyltransferase 3 family.


ensembl_gene_id: YLR259C
symbol: HSP60
gene_biotype: protein_coding
description:
  Heat shock protein 60, mitochondrial; Tetradecameric mitochondrial chaperonin; required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; phosphorylated.


ensembl_gene_id: YLR260W
symbol: LCB5
gene_biotype: protein_coding
description:
  Minor sphingoid long-chain base kinase; possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules; LCB5 has a paralog, LCB4, that arose from the whole genome duplication.


ensembl_gene_id: YLR261C
symbol: VPS63
gene_biotype: protein_coding
description:
  Uncharacterized protein VPS63; Putative protein of unknown function; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene YPT6; deletion causes a vacuolar protein sorting defect; decreased levels of protein in enolase deficient mutant.


ensembl_gene_id: YLR262C
symbol: YPT6
gene_biotype: protein_coding
description:
  GTP-binding protein YPT6; Rab family GTPase; required for endosome-to-Golgii, intra-Golgi retrograde, and retrograde Golgi-to-ER transport; temporarily at the Golgi, dissociating into the cytosol on arrival of the late Golgi GTPase Ypt32p; Golgi-localized form is GTP bound, while cytosolic form is GDP-bound; required for delivery of Atg9p to the phagophore assembly site during autophagy under heat stress, with Ypt6p for starvation induced autophagy and for the CVT pathway; homolog of mammalian Rab6.


ensembl_gene_id: YLR262C-A
symbol: TMA7
gene_biotype: protein_coding
description:
  Protein of unknown that associates with ribosomes; null mutant exhibits translation defects, altered polyribosome profiles, and resistance to the translation inhibitor anisomcyin; protein abundance increases in response to DNA replication stress; Belongs to the TMA7 family.


ensembl_gene_id: YLR263W
symbol: RED1
gene_biotype: protein_coding
description:
  Protein component of the synaptonemal complex axial elements; involved in chromosome segregation during the first meiotic division; critical for coupling checkpoint signaling to SC formation; promotes interhomolog recombination by phosphorylating Hop1p; also interacts with Mec3p and Ddc1p.


ensembl_gene_id: YLR264W
symbol: RPS28B
gene_biotype: protein_coding
description:
  Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S28, no bacterial homolog; has an extraribosomal function in autoregulation, in which Rps28Bp binds to a decapping complex via Edc3p, which then binds to RPS28B mRNA leading to its decapping and degradation; RPS28B has a paralog, RPS28A, that arose from the whole genome duplication.


ensembl_gene_id: YLR265C
symbol: NEJ1
gene_biotype: protein_coding
description:
  Non-homologous end-joining protein 1; Protein involved in regulation of nonhomologous end joining; interacts with DNA ligase IV components Dnl4p and Lif1p; repressed by MAT heterozygosity; regulates cellular distribution of Lif1p.


ensembl_gene_id: YLR266C
symbol: PDR8
gene_biotype: protein_coding
description:
  Transcription factor; targets include ATP-binding cassette (ABC) transporters, major facilitator superfamily transporters, and other genes involved in the pleiotropic drug resistance (PDR) phenomenon; PDR8 has a paralog, YRR1, that arose from the whole genome duplication.


ensembl_gene_id: YLR268W
symbol: SEC22
gene_biotype: protein_coding
description:
  R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog.


ensembl_gene_id: YLR269C
symbol: YLR269C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YLR269C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YLR270W
symbol: DCS1
gene_biotype: protein_coding
description:
  m7GpppX diphosphatase; Non-essential hydrolase involved in mRNA decapping; activates Xrn1p; may function in a feedback mechanism to regulate deadenylation, contains pyrophosphatase activity and a HIT (histidine triad) motif; acts as inhibitor of neutral trehalase Nth1p; required for growth on glycerol medium; protein abundance increases in response to DNA replication stress; DCS1 has a paralog, DCS2, that arose from the whole genome duplication.


ensembl_gene_id: YLR271W
symbol: CMG1
gene_biotype: protein_coding
description:
  Uncharacterized protein YLR271W; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS.


ensembl_gene_id: YLR272C
symbol: YCS4
gene_biotype: protein_coding
description:
  Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation, chromatin binding of condensin, tRNA gene clustering at the nucleolus, and silencing at the mating type locus; required for replication slow zone (RSZ) breakage following Mec1p inactivation; Belongs to the CND1 (condensin subunit 1) family.


ensembl_gene_id: YLR273C
symbol: PIG1
gene_biotype: protein_coding
description:
  Putative targeting subunit for type-1 protein phosphatase Glc7p; tethers Glc7p to Gsy2p glycogen synthase; PIG1 has a paralog, GAC1, that arose from the whole genome duplication.


ensembl_gene_id: YLR274W
symbol: MCM5
gene_biotype: protein_coding
description:
  Minichromosome maintenance protein 5; Component of the Mcm2-7 hexameric helicase complex; MCM complex is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase.


ensembl_gene_id: YLR275W
symbol: SMD2
gene_biotype: protein_coding
description:
  Small nuclear ribonucleoprotein Sm D2; Core Sm protein Sm D2; part of heteroheptameric complex (with Smb1p, Smd1p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D2.


ensembl_gene_id: YLR276C
symbol: DBP9
gene_biotype: protein_coding
description:
  ATP-dependent RNA helicase DBP9; DEAD-box protein required for 27S rRNA processing; exhibits DNA, RNA and DNA/RNA helicase activities; ATPase activity shows preference for DNA over RNA; DNA helicase activity abolished by mutation in RNA-binding domain; Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily.


ensembl_gene_id: YLR277C
symbol: YSH1
gene_biotype: protein_coding
description:
  Endoribonuclease; subunit of the mRNA cleavage and polyadenylation specificity complex; required for 3' processing, splicing, and transcriptional termination of mRNAs and snoRNAs; protein abundance increases in response to DNA replication stress; YSH1 has a paralog, SYC1, that arose from the whole genome duplication; Belongs to the metallo-beta-lactamase superfamily. RNA- metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.


ensembl_gene_id: YLR278C
symbol: YLR278C
gene_biotype: protein_coding
description:
  Uncharacterized transcriptional regulatory protein YLR278C; Zinc-cluster protein; GFP-fusion protein localizes to the nucleus; mutant shows moderate growth defect on caffeine; has a prion-domain like fragment that increases frequency of [URE3]; YLR278C is not an essential gene.


ensembl_gene_id: YLR279W
symbol: YLR279W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YLR279W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YLR280C
symbol: YLR280C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YLR280C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YLR281C
symbol: YLR281C
gene_biotype: protein_coding
description:
  Uncharacterized peptide chain release factor-like protein YLR281C, mitochondrial; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR281C is not an essential gene.


ensembl_gene_id: YLR282C
symbol: YLR282C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YLR282C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion mutation confers an increase in Ty1 transposition.


ensembl_gene_id: YLR283W
symbol: YLR283W
gene_biotype: protein_coding
description:
  Uncharacterized protein YLR283W, mitochondrial; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR283W is not an essential gene.


ensembl_gene_id: YLR284C
symbol: ECI1
gene_biotype: protein_coding
description:
  Peroxisomal delta3,delta2-enoyl-CoA isomerase; hexameric protein that converts 3-hexenoyl-CoA to trans-2-hexenoyl-CoA, essential for the beta-oxidation of unsaturated fatty acids, oleate-induced; ECI1 has a paralog, DCI1, that arose from the whole genome duplication.


ensembl_gene_id: YLR285C-A
symbol: YLR285C-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YLR285C-A; Putative protein of unknown function; identified by fungal homology and RT-PCR.


ensembl_gene_id: YLR285W
symbol: NNT1
gene_biotype: protein_coding
description:
  Protein N-terminal and lysine N-methyltransferase EFM7; S-adenosylmethionine-dependent methyltransferase; novel N-terminal protein methyltransferase that trimethylates the N-terminal glycine residue (G2) and also dimethylates lysine (K3) on elongation factor eEF1A (Tef1p/Tef2p); has a role in rDNA silencing and in lifespan determination.


ensembl_gene_id: YLR286C
symbol: CTS1
gene_biotype: protein_coding
description:
  Endochitinase; required for cell separation after mitosis; transcriptional activation during the G1 phase of the cell cycle is mediated by transcription factor Ace2p.


ensembl_gene_id: YLR286W-A
symbol: YLR286W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YLR286W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene CTS1.


ensembl_gene_id: YLR287C
symbol: YLR287C
gene_biotype: protein_coding
description:
  Uncharacterized protein YLR287C; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR287C is not an essential gene.


ensembl_gene_id: YLR287C-A
symbol: RPS30A
gene_biotype: protein_coding
description:
  Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S30, no bacterial homolog; RPS30A has a paralog, RPS30B, that arose from the whole genome duplication.


ensembl_gene_id: YLR288C
symbol: MEC3
gene_biotype: protein_coding
description:
  DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1.


ensembl_gene_id: YLR289W
symbol: GUF1
gene_biotype: protein_coding
description:
  Translation factor GUF1, mitochondrial; Mitochondrial matrix GTPase; associates with mitochondrial ribosomes; important for translation under temperature and nutrient stress; may have a role in translational fidelity; similar to bacterial LepA elongation factor.


ensembl_gene_id: YLR290C
symbol: COQ11
gene_biotype: protein_coding
description:
  MIOREX complex component 2; Putative oxidoreductase, subunit of Coenzyme Q biosynthetic complexes; required for synthesis of wild-type levels of Coenzyme Q (ubiquinone); member of the short-chain dehydrogenase/reductase (SDR) superfamily; orthologous gene in some other fungi is fused to the COQ10 ortholog.


ensembl_gene_id: YLR291C
symbol: GCD7
gene_biotype: protein_coding
description:
  Beta subunit of the translation initiation factor eIF2B; the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression; human homolog EIF2B2 can complement yeast mutant, allows growth down-regulation of yeast gene; Belongs to the eIF-2B alpha/beta/delta subunits family.


ensembl_gene_id: YLR292C
symbol: SEC72
gene_biotype: protein_coding
description:
  Translocation protein SEC72; Non-essential subunit of Sec63 complex; with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER; other members are Sec63p, Sec62p, and Sec66p.


ensembl_gene_id: YLR293C
symbol: GSP1
gene_biotype: protein_coding
description:
  GTP-binding nuclear protein GSP1/CNR1; Ran GTPase; GTP binding protein (mammalian Ranp homolog) involved in the maintenance of nuclear organization, RNA processing and transport; regulated by Srm1p, Rna1p, Yrb1p, Yrb2p, Yrp4p, Yrb30p, Cse1p and Kap95p; GSP1 has a paralog, GSP2, that arose from the whole genome duplication; Belongs to the small GTPase superfamily. Ran family.


ensembl_gene_id: YLR294C
symbol: YLR294C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YLR294C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ATP14.


ensembl_gene_id: YLR295C
symbol: ATP14
gene_biotype: protein_coding
description:
  Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YLR296W
symbol: YLR296W
gene_biotype: protein_coding
description:
  Uncharacterized protein YLR296W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YLR297W
symbol: YLR297W
gene_biotype: protein_coding
description:
  Uncharacterized vacuolar protein YLR297W; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; not an essential gene; induced by treatment with 8-methoxypsoralen and UVA irradiation; relocalizes from nucleus to vacuole upon DNA replication stress; YLR297W has a paralog, YOR186W, that arose from the whole genome duplication.


ensembl_gene_id: YLR298C
symbol: YHC1
gene_biotype: protein_coding
description:
  U1 small nuclear ribonucleoprotein C; Component of the U1 snRNP complex required for pre-mRNA splicing; putative ortholog of human U1C protein, which is involved in formation of a complex between U1 snRNP and the pre-mRNA 5' splice site; Belongs to the U1 small nuclear ribonucleoprotein C family.


ensembl_gene_id: YLR299C-A
symbol: YLR299C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YLR299C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene ECM38.


ensembl_gene_id: YLR299W
symbol: ECM38
gene_biotype: protein_coding
description:
  Glutathione hydrolase heavy chain; Gamma-glutamyltranspeptidase; major glutathione-degrading enzyme; involved in detoxification of electrophilic xenobiotics; expression induced mainly by nitrogen starvation.


ensembl_gene_id: YLR300W
symbol: EXG1
gene_biotype: protein_coding
description:
  Glucan 1,3-beta-glucosidase I/II; Major exo-1,3-beta-glucanase of the cell wall; involved in cell wall beta-glucan assembly; exists as three differentially glycosylated isoenzymes; EXG1 has a paralog, SPR1, that arose from the whole genome duplication; Belongs to the glycosyl hydrolase 5 (cellulase A) family.


ensembl_gene_id: YLR302C
symbol: YLR302C
gene_biotype: protein_coding
description:
  Uncharacterized protein YLR302C; Putative protein of unknown function; conserved among S. cerevisiae strains.


ensembl_gene_id: YLR303W
symbol: MET17
gene_biotype: protein_coding
description:
  Homocysteine/cysteine synthase; O-acetyl homoserine-O-acetyl serine sulfhydrylase; required for Methionine and cysteine biosynthesis; Belongs to the trans-sulfuration enzymes family.


ensembl_gene_id: YLR304C
symbol: ACO1
gene_biotype: protein_coding
description:
  Aconitate hydratase, mitochondrial; Aconitase; required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy; human homolog ACO2 can complement yeast null mutant.


ensembl_gene_id: YLR305C
symbol: STT4
gene_biotype: protein_coding
description:
  Phosphatidylinositol-4-kinase; functions in the Pkc1p protein kinase pathway; required for normal vacuole morphology, cell wall integrity, and actin cytoskeleton organization; Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.


ensembl_gene_id: YLR306W
symbol: UBC12
gene_biotype: protein_coding
description:
  NEDD8-conjugating enzyme UBC12; Enzyme that mediates the conjugation of Rub1p; a ubiquitin-like protein, to other proteins; related to E2 ubiquitin-conjugating enzymes.


ensembl_gene_id: YLR307W
symbol: CDA1
gene_biotype: protein_coding
description:
  Chitin deacetylase; together with Cda2p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall.


ensembl_gene_id: YLR308W
symbol: CDA2
gene_biotype: protein_coding
description:
  Chitin deacetylase; together with Cda1p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall.


ensembl_gene_id: YLR309C
symbol: IMH1
gene_biotype: protein_coding
description:
  Golgin IMH1; Protein involved in vesicular transport; mediates transport between an endosomal compartment and the Golgi, contains a Golgi-localization (GRIP) domain that interacts with activated Arl1p-GTP to localize Imh1p to the Golgi.


ensembl_gene_id: YLR310C
symbol: CDC25
gene_biotype: protein_coding
description:
  Cell division control protein 25; Membrane bound guanine nucleotide exchange factor; also known as a GEF or GDP-release factor; indirectly regulates adenylate cyclase through activation of Ras1p and Ras2p by stimulating the exchange of GDP for GTP; required for progression through G1; thermosensitivity of the cdc25-5 mutant is functionally complemented by human RASGRF1 or by a fragment of human SOS1 comprising the CDC25-related catalytic domain.


ensembl_gene_id: YLR311C
symbol: YLR311C
gene_biotype: protein_coding
description:
  Putative uncharacterized membrane protein YLR311C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YLR312C
symbol: ATG39
gene_biotype: protein_coding
description:
  Autophagy-related protein 39; Autophagy receptor with a role in degradation of the ER and nucleus; involved specifically in autophagy of perinuclear endoplasmic reticulum in response to nitrogen starvation or rapamycin treatment; localizes to the perinuclear ER.


ensembl_gene_id: YLR312W-A
symbol: MRPL15
gene_biotype: protein_coding
description:
  Mitochondrial ribosomal protein of the large subunit; Belongs to the ribonuclease III family. Mitochondrion- specific ribosomal protein mL57 subfamily.


ensembl_gene_id: YLR313C
symbol: SPH1
gene_biotype: protein_coding
description:
  Protein involved in shmoo formation and bipolar bud site selection; localizes to sites of polarized growth in a cell cycle dependent- and Spa2p-dependent manner, interacts with MAPKKs Mkk1p, Mkk2p, and Ste7p; SPH1 has a paralog, SPA2, that arose from the whole genome duplication.


ensembl_gene_id: YLR314C
symbol: CDC3
gene_biotype: protein_coding
description:
  Cell division control protein 3; Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble with other septins into rod-like complexes that can associate with other rods to form filament polymers; septin rings at the mother-bud neck act as scaffolds for recruiting factors needed for cell division and as barriers to prevent diffusion of specific proteins between mother and daughter cells; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.


ensembl_gene_id: YLR315W
symbol: NKP2
gene_biotype: protein_coding
description:
  Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein cnl2.


ensembl_gene_id: YLR316C
symbol: TAD3
gene_biotype: protein_coding
description:
  Subunit of tRNA-specific adenosine-34 deaminase; forms a heterodimer with Tad2p that converts adenosine to inosine at the wobble position of several tRNAs; Belongs to the cytidine and deoxycytidylate deaminase family. ADAT3 subfamily.


ensembl_gene_id: YLR317W
symbol: YLR317W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YLR317W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; may be part of a bicistronic transcript with NKP2/YLR315W; overlaps the verified ORF TAD3/YLR316C.


ensembl_gene_id: YLR318W
symbol: EST2
gene_biotype: protein_coding
description:
  Reverse transcriptase subunit of the telomerase holoenzyme; essential for telomerase core catalytic activity, involved in other aspects of telomerase assembly and function; mutations in human homolog are associated with aplastic anemia.


ensembl_gene_id: YLR319C
symbol: BUD6
gene_biotype: protein_coding
description:
  Bud site selection protein 6; Actin- and formin-interacting protein; participates in actin cable assembly and organization as a nucleation-promoting factor (NPF) for formins Bni1p and Bnr1p; a triple helical coiled-coil domain in the C-terminal region interacts with Bni1p; involved in polarized cell growth; isolated as bipolar budding mutant; potential Cdc28p substrate.


ensembl_gene_id: YLR320W
symbol: MMS22
gene_biotype: protein_coding
description:
  E3 ubiquitin-protein ligase substrate receptor MMS22; Subunit of E3 ubiquitin ligase complex involved in replication repair; stabilizes protein components of the replication fork, such as the fork-pausing complex and leading strand polymerase, preventing fork collapse and promoting efficient recovery during replication stress; required for accurate meiotic chromosome segregation; Belongs to the MMS22 family.


ensembl_gene_id: YLR321C
symbol: SFH1
gene_biotype: protein_coding
description:
  Chromatin structure-remodeling complex subunit SFH1; Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog; hSNF5 tumor suppressor ortholog.


ensembl_gene_id: YLR322W
symbol: VPS65
gene_biotype: protein_coding
description:
  Putative uncharacterized protein VPS65; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; 75% of ORF overlaps the verified gene SFH1; deletion causes a vacuolar protein sorting defect and blocks anaerobic growth.


ensembl_gene_id: YLR323C
symbol: CWC24
gene_biotype: protein_coding
description:
  Pre-mRNA-splicing factor CWC24; General splicing factor; required for stable U2 snRNP binding to primary transcripts; essential for the first step of splicing; component of the pre-catalytic spliceosome complex containing Cef1p; similar to S. pombe Cwf24p; Belongs to the CWC24 family.


ensembl_gene_id: YLR324W
symbol: PEX30
gene_biotype: protein_coding
description:
  ER-resident protein involved in peroxisomal biogenesis; ER-localized protein that associates with peroxisomes; interacts with Pex29p and reticulons Rtn1p and Yop1p to regulate peroxisome biogenesis from the ER; role in peroxisomal-destined vesicular flow from the ER; partially redundant with Pex31p; may function at a step downstream of steps mediated by Pex28p and Pex29p; PEX30 has a paralog, PEX31, that arose from the whole genome duplication; Belongs to the PEX28-32 family. PEX30/31 subfamily.


ensembl_gene_id: YLR325C
symbol: RPL38
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L38; homologous to mammalian ribosomal protein L38, no bacterial homolog; Belongs to the eukaryotic ribosomal protein eL38 family.


ensembl_gene_id: YLR326W
symbol: YLR326W
gene_biotype: protein_coding
description:
  Uncharacterized membrane protein YLR326W; Putative protein of unknown function; SWAT-GFP and mCherry fusion proteins localize to the cell periphery; predicted to be palmitoylated.


ensembl_gene_id: YLR327C
symbol: TMA10
gene_biotype: protein_coding
description:
  Translation machinery-associated protein 10; Protein of unknown function that associates with ribosomes; protein abundance increases in response to DNA replication stress; TMA10 has a paralog, STF2, that arose from the whole genome duplication.


ensembl_gene_id: YLR328W
symbol: NMA1
gene_biotype: protein_coding
description:
  Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways; homolog of human NMNAT; NMA1 has a paralog, NMA2, that arose from the whole genome duplication.


ensembl_gene_id: YLR329W
symbol: REC102
gene_biotype: protein_coding
description:
  Protein involved in early stages of meiotic recombination; required for chromosome synapsis; forms a complex with Rec104p and Spo11p necessary during the initiation of recombination.


ensembl_gene_id: YLR330W
symbol: CHS5
gene_biotype: protein_coding
description:
  Chitin biosynthesis protein CHS5; Component of the exomer complex; the exomer which also contains Csh6p, Bch1p, Bch2p, and Bud7, is involved in the export of select proteins, such as chitin synthase Chs3p, from the Golgi to the plasma membrane; interacts selectively with the activated, GTP-bound form of Arf1p; Chs5p is the only protein with a BRCT domain that is not localized to the nucleus.


ensembl_gene_id: YLR331C
symbol: JIP3
gene_biotype: protein_coding
description:
  Uncharacterized protein JIP3; Putative protein of unknown function; conserved among S. cerevisiae strains; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2.


ensembl_gene_id: YLR332W
symbol: MID2
gene_biotype: protein_coding
description:
  Cell wall integrity sensor MID2; O-glycosylated plasma membrane protein; acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p; MID2 has a paralog, MTL1, that arose from the whole genome duplication.


ensembl_gene_id: YLR333C
symbol: RPS25B
gene_biotype: protein_coding
description:
  Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S25, no bacterial homolog; RPS25B has a paralog, RPS25A, that arose from the whole genome duplication.


ensembl_gene_id: YLR334C
symbol: YLR334C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YLR334C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps a stand-alone long terminal repeat sequence whose presence indicates a retrotransposition event occurred here.


ensembl_gene_id: YLR335W
symbol: NUP2
gene_biotype: protein_coding
description:
  Nucleoporin involved in nucleocytoplasmic transport; binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels; also has a role in chromatin organization.


ensembl_gene_id: YLR336C
symbol: SGD1
gene_biotype: protein_coding
description:
  Suppressor of glycerol defect protein 1; Essential nuclear protein; required for biogenesis of the small ribosomal subunit; has a possible role in the osmoregulatory glycerol response; putative homolog of human NOM1 which is implicated in acute myeloid leukemia.


ensembl_gene_id: YLR337C
symbol: VRP1
gene_biotype: protein_coding
description:
  Verprolin, proline-rich actin-associated protein; involved in cytoskeletal organization and cytokinesis; promotes actin nucleation and endocytosis; related to mammalian Wiskott-Aldrich syndrome protein (WASP)-interacting protein (WIP); Belongs to the verprolin family.


ensembl_gene_id: YLR338W
symbol: OPI9
gene_biotype: protein_coding
description:
  Putative uncharacterized protein OPI9; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF VRP1/YLR337C.


ensembl_gene_id: YLR339C
symbol: YLR339C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YLR339C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPP0.


ensembl_gene_id: YLR340W
symbol: RPP0
gene_biotype: protein_coding
description:
  Conserved ribosomal protein P0 of the ribosomal stalk; involved in interaction between translational elongation factors and the ribosome; phosphorylated on serine 302; homologous to mammalian ribosomal protein LP0 and bacterial L10.


ensembl_gene_id: YLR341W
symbol: SPO77
gene_biotype: protein_coding
description:
  Sporulation-specific protein 77; Meiosis-specific protein of unknown function; required for spore wall formation during sporulation and for timely prospore membrane closure along with SPS1; required with Sps1p for phosphorylation and turnover of Ssp1p; dispensable for both nuclear divisions during meiosis.


ensembl_gene_id: YLR342W
symbol: FKS1
gene_biotype: protein_coding
description:
  1,3-beta-glucan synthase component FKS1; Catalytic subunit of 1,3-beta-D-glucan synthase; functionally redundant with alternate catalytic subunit Gsc2p; binds to regulatory subunit Rho1p; involved in cell wall synthesis and maintenance; localizes to sites of cell wall remodeling; FKS1 has a paralog, GSC2, that arose from the whole genome duplication.


ensembl_gene_id: YLR343W
symbol: GAS2
gene_biotype: protein_coding
description:
  1,3-beta-glucanosyltransferase; involved with Gas4p in spore wall assembly; has similarity to Gas1p; Belongs to the glycosyl hydrolase 72 family.


ensembl_gene_id: YLR344W
symbol: RPL26A
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L26A; binds to 5.8S rRNA; non-essential even when paralog is also deleted; deletion has minimal affections on ribosome biosynthesis; homologous to mammalian ribosomal protein L26 and bacterial L24; RPL26A has a paralog, RPL26B, that arose from the whole genome duplication.


ensembl_gene_id: YLR345W
symbol: YLR345W
gene_biotype: protein_coding
description:
  Putative 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase YLR345W; Similar to 6-phosphofructo-2-kinase enzymes; mRNA expression is repressed by the Rfx1p-Tup1p-Ssn6p repressor complex; YLR345W is not an essential gene; In the C-terminal section; belongs to the phosphoglycerate mutase family.


ensembl_gene_id: YLR346C
symbol: CIS1
gene_biotype: protein_coding
description:
  Citrinin resistance protein, mitochondrial; Protein of unknown function found in mitochondria; expression is regulated by transcription factors involved in pleiotropic drug resistance, Pdr1p and Yrr1p; not an essential gene; YLR346C has a paralog, YGR035C, that arose from the whole genome duplication.


ensembl_gene_id: YLR347C
symbol: KAP95
gene_biotype: protein_coding
description:
  Importin subunit beta-1; Karyopherin beta; forms a complex with Srp1p/Kap60p; interacts with nucleoporins to mediate nuclear import of NLS-containing cargo proteins via the nuclear pore complex; regulates PC biosynthesis; GDP-to-GTP exchange factor for Gsp1p.


ensembl_gene_id: YLR347W-A
symbol: YLR347W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YLR347W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified ORF KAP95/YLR347C.


ensembl_gene_id: YLR348C
symbol: DIC1
gene_biotype: protein_coding
description:
  Mitochondrial dicarboxylate carrier; integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix.


ensembl_gene_id: YLR349W
symbol: YLR349W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YLR349W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified ORF DIC1/YLR348C.


ensembl_gene_id: YLR350W
symbol: ORM2
gene_biotype: protein_coding
description:
  Protein that mediates sphingolipid homeostasis; evolutionarily conserved, required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control; protein abundance increases in response to DNA replication stress; ORM2 has a paralog, ORM1, that arose from the whole genome duplication.


ensembl_gene_id: YLR351C
symbol: NIT3
gene_biotype: protein_coding
description:
  Omega-amidase NIT3; Nit protein; one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member.


ensembl_gene_id: YLR352W
symbol: YLR352W
gene_biotype: protein_coding
description:
  F-box protein YLR352W; Putative protein of unknown function with similarity to F-box proteins; interacts with Skp1p and Cdc53p; YLR352W is not an essential gene.


ensembl_gene_id: YLR353W
symbol: BUD8
gene_biotype: protein_coding
description:
  Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole; BUD8 has a paralog, BUD9, that arose from the whole genome duplication.


ensembl_gene_id: YLR354C
symbol: TAL1
gene_biotype: protein_coding
description:
  Transaldolase, enzyme in the non-oxidative pentose phosphate pathway; converts sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate to erythrose 4-phosphate and fructose 6-phosphate; TAL1 has a paralog, NQM1, that arose from the whole genome duplication.


ensembl_gene_id: YLR355C
symbol: ILV5
gene_biotype: protein_coding
description:
  Ketol-acid reductoisomerase, mitochondrial; Acetohydroxyacid reductoisomerase and mtDNA binding protein; involved in branched-chain amino acid biosynthesis and maintenance of wild-type mitochondrial DNA; found in mitochondrial nucleoids.


ensembl_gene_id: YLR356W
symbol: ATG33
gene_biotype: protein_coding
description:
  Autophagy-related protein 33; Mitochondrial mitophagy-specific protein; required primarily for mitophagy induced at post-log phase; not required for other types of selective autophagy or macroautophagy; conserved within fungi, but not in higher eukaryotes; ATG33 has a paralog, SCM4, that arose from the whole genome duplication.


ensembl_gene_id: YLR357W
symbol: RSC2
gene_biotype: protein_coding
description:
  Chromatin structure-remodeling complex subunit RSC2; Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; involved in telomere maintenance; RSC2 has a paralog, RSC1, that arose from the whole genome duplication; Belongs to the RSC1 family.


ensembl_gene_id: YLR358C
symbol: YLR358C
gene_biotype: protein_coding
description:
  Uncharacterized protein YLR358C; Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps ORF RSC2/YLR357W.


ensembl_gene_id: YLR359W
symbol: ADE13
gene_biotype: protein_coding
description:
  Adenylosuccinate lyase; catalyzes two steps in the 'de novo' purine nucleotide biosynthetic pathway; expression is repressed by adenine and activated by Bas1p and Pho2p; mutations in human ortholog ADSL cause adenylosuccinase deficiency; human ADSL can complement yeast ADE13 null mutant.


ensembl_gene_id: YLR360W
symbol: VPS38
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 38; Part of a Vps34p phosphatidylinositol 3-kinase complex; functions in carboxypeptidase Y (CPY) sorting; binds Vps30p and Vps34p to promote production of phosphatidylinositol 3-phosphate (PtdIns3P) which stimulates kinase activity; required for overflow degradation of misfolded proteins when ERAD is saturated.


ensembl_gene_id: YLR361C
symbol: DCR2
gene_biotype: protein_coding
description:
  Protein phosphatase; involved in downregulation of the unfolded protein response (UPR), at least in part through dephosphorylation of Ire1p; dosage-dependent positive regulator of the G1/S phase transition through control of the timing of START; physically interacts with, dephosphorylates and destabilizes Sic1p; SWAT-GFP and mCherry fusion proteins localize to the vacuole.


ensembl_gene_id: YLR362W
symbol: STE11
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase STE11; Signal transducing MEK kinase; involved in pheromone response and pseudohyphal/invasive growth pathways where it phosphorylates Ste7p, and the high osmolarity response pathway, via phosphorylation of Pbs2p; regulated by Ste20p and Ste50p; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YLR363C
symbol: NMD4
gene_biotype: protein_coding
description:
  Protein that may be involved in nonsense-mediated mRNA decay; interacts with Nam7p, relocalizes from nucleus to cytoplasmic foci upon DNA replication stress.


ensembl_gene_id: YLR363W-A
symbol: YLR363W-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YLR363W-A; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; relocalizes from nucleus to nucleolus upon DNA replication stress.


ensembl_gene_id: YLR364C-A
symbol: YLR364C-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YLR364C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR366W.


ensembl_gene_id: YLR364W
symbol: GRX8
gene_biotype: protein_coding
description:
  Glutaredoxin-8; Glutaredoxin that employs a dithiol mechanism of catalysis; monomeric; activity is low and null mutation does not affect sensitivity to oxidative stress; GFP-fusion protein localizes to the cytoplasm; expression strongly induced by arsenic.


ensembl_gene_id: YLR365W
symbol: YLR365W
gene_biotype: protein_coding
description:
  Uncharacterized protein YLR365W; Putative protein of unknown function; conserved among S. cerevisiae strains; YLR365W is not an essential gene.


ensembl_gene_id: YLR366W
symbol: YLR366W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YLR366W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR364C-A.


ensembl_gene_id: YLR367W
symbol: RPS22B
gene_biotype: protein_coding
description:
  Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication.


ensembl_gene_id: YLR368W
symbol: MDM30
gene_biotype: protein_coding
description:
  Mitochondrial distribution and morphology protein 30; F-box component of an SCF ubiquitin protein ligase complex; associates with and is required for Fzo1p ubiquitination and for mitochondria fusion; stimulates nuclear export of specific mRNAs; promotes ubiquitin-mediated degradation of Gal4p in some strains.


ensembl_gene_id: YLR369W
symbol: SSQ1
gene_biotype: protein_coding
description:
  Heat shock protein SSQ1, mitochondrial; Mitochondrial hsp70-type molecular chaperone; required for assembly of iron/sulfur clusters into proteins at a step after cluster synthesis, and for maturation of Yfh1p, which is a homolog of human frataxin implicated in Friedreich's ataxia.


ensembl_gene_id: YLR370C
symbol: ARC18
gene_biotype: protein_coding
description:
  Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches.


ensembl_gene_id: YLR371W
symbol: ROM2
gene_biotype: protein_coding
description:
  Guanine nucleotide exchange factor (GEF) for Rho1p and Rho2p; mutations are synthetically lethal with mutations in rom1, which also encodes a GEF; Rom2p localization to the bud surface is dependent on Ack1p; ROM2 has a paralog, ROM1, that arose from the whole genome duplication.


ensembl_gene_id: YLR372W
symbol: ELO3
gene_biotype: protein_coding
description:
  Elongation of fatty acids protein 3; Elongase; involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis; lethality of the elo2 elo3 double null mutation is functionally complemented by human ELOVL1 and weakly complemented by human ELOVL3 or ELOV7; Belongs to the ELO family.


ensembl_gene_id: YLR373C
symbol: VID22
gene_biotype: protein_coding
description:
  Vacuolar import and degradation protein 22; Glycosylated integral membrane protein localized to plasma membrane; plays a role in fructose-1,6-bisphosphatase (FBPase) degradation; involved in FBPase transport from the cytosol to Vid (vacuole import and degradation) vesicles; VID22 has a paralog, ENV11, that arose from the whole genome duplication.


ensembl_gene_id: YLR374C
symbol: YLR374C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YLR374C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF STP3/YLR375W.


ensembl_gene_id: YLR375W
symbol: STP3
gene_biotype: protein_coding
description:
  Zinc-finger protein of unknown function; possibly involved in pre-tRNA splicing and in uptake of branched-chain amino acids; STP3 has a paralog, STP4, that arose from the whole genome duplication.


ensembl_gene_id: YLR376C
symbol: PSY3
gene_biotype: protein_coding
description:
  Platinum sensitivity protein 3; Component of Shu complex (aka PCSS complex); Shu complex also includes Shu1, Csm2, Shu2, and promotes error-free DNA repair; promotes Rad51p filament assembly; Shu complex mediates inhibition of Srs2p function; Psy3p and Csm2p contain similar DNA-binding regions which work together to form a single DNA binding site; deletion of PSY3 results in a mutator phenotype; deletion increases sensitivity to anticancer drugs oxaliplatin and cisplatin but not mitomycin C.


ensembl_gene_id: YLR377C
symbol: FBP1
gene_biotype: protein_coding
description:
  Fructose-1,6-bisphosphatase; key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism; undergoes either proteasome-mediated or autophagy-mediated degradation depending on growth conditions; glucose starvation results in redistribution to the periplasm; interacts with Vid30p; Belongs to the FBPase class 1 family.


ensembl_gene_id: YLR378C
symbol: SEC61
gene_biotype: protein_coding
description:
  Conserved ER protein translocation channel; essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms channel for SRP-dependent protein import; with Sec63 complex allows SRP-independent protein import into ER; involved in posttranslational soluble protein import into the ER, ERAD of soluble substrates, and misfolded soluble protein export from the ER.


ensembl_gene_id: YLR379W
symbol: YLR379W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YLR379W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the essential ORF SEC61/YLR378C.


ensembl_gene_id: YLR380W
symbol: CSR1
gene_biotype: protein_coding
description:
  Phosphatidylinositol transfer protein; has a potential role in regulating lipid and fatty acid metabolism under heme-depleted conditions; interacts specifically with thioredoxin peroxidase; may have a role in oxidative stress resistance; protein abundance increases in response to DNA replication stress; Belongs to the PITP family.


ensembl_gene_id: YLR381W
symbol: CTF3
gene_biotype: protein_coding
description:
  Inner kinetochore subunit CTF3; Outer kinetochore protein that forms a complex with Mcm16p and Mcm22p; may bind the kinetochore to spindle microtubules; required for the spindle assembly checkpoint; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-I and fission yeast mis6; Belongs to the CENP-I/CTF3 family.


ensembl_gene_id: YLR382C
symbol: NAM2
gene_biotype: protein_coding
description:
  Leucine--tRNA ligase, mitochondrial; Mitochondrial leucyl-tRNA synthetase; also has direct role in splicing of several mitochondrial group I introns; indirectly required for mitochondrial genome maintenance; human homolog LARS2 can complement yeast null mutant, and is implicated in Perrault syndrome; Belongs to the class-I aminoacyl-tRNA synthetase family.


ensembl_gene_id: YLR383W
symbol: SMC6
gene_biotype: protein_coding
description:
  Structural maintenance of chromosomes protein 6; Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; homologous to S. pombe rad18.


ensembl_gene_id: YLR384C
symbol: IKI3
gene_biotype: protein_coding
description:
  Subunit of Elongator complex; Elongator is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD); Belongs to the ELP1/IKA1 family.


ensembl_gene_id: YLR385C
symbol: SWC7
gene_biotype: protein_coding
description:
  SWR1-complex protein 7; Protein of unknown function; component of the Swr1p complex that incorporates Htz1p into chromatin; Belongs to the SWC7 family.


ensembl_gene_id: YLR386W
symbol: VAC14
gene_biotype: protein_coding
description:
  Vacuole morphology and inheritance protein 14; Enzyme regulator; involved in synthesis of phosphatidylinositol 3,5-bisphosphate, in control of trafficking of some proteins to the vacuole lumen via the MVB, and in maintenance of vacuole size and acidity; binds negative (Fig4p) and positive (Fab1p) regulators of PtdIns(3,5)P(2) to control endolysosome function; similar to mammalian Vac14p.


ensembl_gene_id: YLR387C
symbol: REH1
gene_biotype: protein_coding
description:
  Cytoplasmic 60S subunit biogenesis factor; associates with pre-60S particles; similar to Rei1p and shares partially redundant function in cytoplasmic 60S subunit maturation; contains dispersed C2H2 zinc finger domains; Belongs to the REI1 family.


ensembl_gene_id: YLR388W
symbol: RPS29A
gene_biotype: protein_coding
description:
  Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S29 and bacterial S14; RPS29A has a paralog, RPS29B, that arose from the whole genome duplication.


ensembl_gene_id: YLR389C
symbol: STE23
gene_biotype: protein_coding
description:
  A-factor-processing enzyme; Metalloprotease; involved in N-terminal processing of pro-a-factor to mature form; expressed in both haploids and diploids; one of two yeast homologs of human insulin-degrading enzyme (hIDE); homolog Axl1p is also involved in processing of pro-a-factor; Belongs to the peptidase M16 family.


ensembl_gene_id: YLR390W
symbol: ECM19
gene_biotype: protein_coding
description:
  Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies.


ensembl_gene_id: YLR390W-A
symbol: CCW14
gene_biotype: protein_coding
description:
  Covalently linked cell wall glycoprotein; present in the inner layer of the cell wall; Belongs to the CCW14 family.


ensembl_gene_id: YLR392C
symbol: ART10
gene_biotype: protein_coding
description:
  Arrestin-related trafficking adapter 10; Protein of unknown function that contains 2 PY motifs; ubiquinated by Rsp5p; overexpression confers resistance to arsenite; green fluorescent protein (GFP)-fusion protein localizes it to the cytoplasm; non-essential gene; Belongs to the ART10 family.


ensembl_gene_id: YLR393W
symbol: ATP10
gene_biotype: protein_coding
description:
  Mitochondrial ATPase complex subunit ATP10; Assembly factor for the F0 sector of mitochondrial F1F0 ATP synthase; mitochondrial inner membrane protein; interacts genetically with ATP6; Belongs to the ATP10 family.


ensembl_gene_id: YLR394W
symbol: CST9
gene_biotype: protein_coding
description:
  Chromosome stability protein 9; SUMO E3 ligase; required for synaptonemal complex formation; localizes to synapsis initiation sites on meiotic chromosomes; associates with centromeres early in meiosis, then with chromosome axes and finally with double-strand break sites that are engaged in repair by crossovers; potential Cdc28p substrate.


ensembl_gene_id: YLR395C
symbol: COX8
gene_biotype: protein_coding
description:
  Subunit VIII of cytochrome c oxidase (Complex IV); Complex IV is the terminal member of the mitochondrial inner membrane electron transport chain.


ensembl_gene_id: YLR396C
symbol: VPS33
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 33; ATP-binding protein that is a subunit of the HOPS and CORVET complexes; essential for protein sorting, vesicle docking, and fusion at the vacuole; binds to SNARE domains.


ensembl_gene_id: YLR397C
symbol: AFG2
gene_biotype: protein_coding
description:
  ATPase family gene 2 protein; ATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexameric complex; is essential for pre-60S maturation and release of several preribosome maturation factors; releases Rlp24p from purified pre-60S particles in vitro; target of the ribosomal biosynthesis inhibitor diazaborine; may be involved in degradation of aberrant mRNAs.


ensembl_gene_id: YLR398C
symbol: SKI2
gene_biotype: protein_coding
description:
  Antiviral helicase SKI2; Ski complex component and putative RNA helicase; mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay; mutations in the human ortholog, SKIV2L, causes Syndromic diarrhea/Trichohepatoenteric (SD/THE) syndrome; Belongs to the helicase family. SKI2 subfamily.


ensembl_gene_id: YLR399C
symbol: BDF1
gene_biotype: protein_coding
description:
  Bromodomain-containing factor 1; Protein involved in transcription initiation; functions at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf2p; BDF1 has a paralog, BDF2, that arose from the whole genome duplication.


ensembl_gene_id: YLR399W-A
symbol: YLR399W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YLR399W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the characterized ORF BDF1/YLR399C.


ensembl_gene_id: YLR400W
symbol: YLR400W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YLR400W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YLR401C
symbol: DUS3
gene_biotype: protein_coding
description:
  tRNA-dihydrouridine(47) synthase [NAD(P)(+)]; Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region; forms nuclear foci upon DNA replication stress.


ensembl_gene_id: YLR402W
symbol: YLR402W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YLR402W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YLR403W
symbol: SFP1
gene_biotype: protein_coding
description:
  Transcription factor SFP1; Regulates transcription of ribosomal protein and biogenesis genes; regulates response to nutrients and stress, G2/M transitions during mitotic cell cycle and DNA-damage response, and modulates cell size; regulated by TORC1 and Mrs6p; sequence of zinc finger, ChIP localization data, and protein-binding microarray (PBM) data, and computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p at others; can form the [ISP+] prion.


ensembl_gene_id: YLR404W
symbol: SEI1
gene_biotype: protein_coding
description:
  Seipin involved in lipid droplet (LD) assembly; controls lipid particle morphology, number, and size; promotes initiation of LD formation on the ER; ensures that LDs bud from the ER towards the cytosolic side of the membrane; forms a complex with Ldb16p at ER-LD contact sites, stabilizing these sites; null mutants have localized accumulation of phosphatidic acid (PA) marker proteins; BSCL2, human homolog implicated in congenital lipodystrophy, complements yeast null mutant.


ensembl_gene_id: YLR405W
symbol: DUS4
gene_biotype: protein_coding
description:
  tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]; Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p; Belongs to the Dus family. Dus4 subfamily.


ensembl_gene_id: YLR406C
symbol: RPL31B
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L31B; associates with karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality; homologous to mammalian ribosomal protein L31, no bacterial homolog; RPL31B has a paralog, RPL31A, that arose from the whole genome duplication.


ensembl_gene_id: YLR406C-A
symbol: YLR406C-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YLR406C-A; Putative protein of unknown function; SWAT-GFP fusion protein localizes to the endoplasmic reticulum and vacuole, while mCherry fusion localizes to just the vacuole.


ensembl_gene_id: YLR407W
symbol: YLR407W
gene_biotype: protein_coding
description:
  Uncharacterized protein YLR407W; Putative protein of unknown function; null mutant displays elongated buds and a large fraction of budded cells have only one nucleus.


ensembl_gene_id: YLR408C
symbol: BLS1
gene_biotype: protein_coding
description:
  Subunit of the BLOC-1 complex involved in endosomal maturation; green fluorescent protein (GFP)-fusion protein localizes to the endosome; YLR408C is not an essential gene; Belongs to the BLOC1S1 family.


ensembl_gene_id: YLR409C
symbol: UTP21
gene_biotype: protein_coding
description:
  U3 small nucleolar RNA-associated protein 21; Subunit of U3-containing 90S preribosome and SSU processome complexes; involved in production of 18S rRNA and assembly of small ribosomal subunit; synthetic defect with STI1 Hsp90 cochaperone; human homolog linked to glaucoma; Small Subunit processome is also known as SSU processome.


ensembl_gene_id: YLR410W
symbol: VIP1
gene_biotype: protein_coding
description:
  Inositol hexakisphosphate and inositol heptakisphosphate kinase; inositol heptakisphosphate (IP7) production is important for phosphate signaling; involved in cortical actin cytoskeleton function, and invasive pseudohyphal growth analogous to S. pombe asp1; inositol hexakisphosphate is also known as IP6; Belongs to the histidine acid phosphatase family. VIP1 subfamily.


ensembl_gene_id: YLR411W
symbol: CTR3
gene_biotype: protein_coding
description:
  High-affinity copper transporter of the plasma membrane; acts as a trimer; gene is disrupted by a Ty2 transposon insertion in many laboratory strains of S. cerevisiae.


ensembl_gene_id: YLR412W
symbol: BER1
gene_biotype: protein_coding
description:
  SRR1-like protein BER1; Protein involved in microtubule-related processes; GFP-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YLR412W is not an essential gene; similar to Arabidopsis SRR1 gene.


ensembl_gene_id: YLR413W
symbol: INA1
gene_biotype: protein_coding
description:
  Cell membrane protein YLR413W; Protein of unknown function; not an essential gene; YLR413W has a paralog, FAT3, that arose from the whole genome duplication.


ensembl_gene_id: YLR414C
symbol: PUN1
gene_biotype: protein_coding
description:
  Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress.


ensembl_gene_id: YLR415C
symbol: YLR415C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YLR415C, mitochondrial; Putative protein of unknown function; YLR415C is not an essential gene.


ensembl_gene_id: YLR416C
symbol: YLR416C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YLR416C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YLR417W
symbol: VPS36
gene_biotype: protein_coding
description:
  Vacuolar protein-sorting-associated protein 36; Component of the ESCRT-II complex; contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into the endosome; plays a role in the formation of mutant huntingtin (Htt) aggregates in yeast; Belongs to the VPS36 family.


ensembl_gene_id: YLR418C
symbol: CDC73
gene_biotype: protein_coding
description:
  Cell division control protein 73; Component of the Paf1p complex; binds to and modulates the activity of RNA polymerases I and II; required for expression of certain genes, modification of some histones, and telomere maintenance; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay; protein abundance increases in response to DNA replication stress; human homolog, parafibromin, is a tumour suppressor linked to breast, renal and gastric cancers; Belongs to the CDC73 family.


ensembl_gene_id: YLR419W
symbol: YLR419W
gene_biotype: protein_coding
description:
  Putative ATP-dependent RNA helicase YLR419W; Putative helicase with limited sequence similarity to human Rb protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR419W is not an essential gene; Belongs to the DEAD box helicase family. DEAH subfamily.


ensembl_gene_id: YLR420W
symbol: URA4
gene_biotype: protein_coding
description:
  Dihydroorotase; catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate.


ensembl_gene_id: YLR421C
symbol: RPN13
gene_biotype: protein_coding
description:
  Subunit of the 19S regulatory particle of the 26S proteasome lid; acts as a ubiquitin receptor for the proteasome; null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; protein abundance increases in response to DNA replication stress; Belongs to the RPN13 family.


ensembl_gene_id: YLR422W
symbol: DCK1
gene_biotype: protein_coding
description:
  DOCK-like protein 1; Dock family protein (Dedicator Of CytoKinesis), homolog of human DOCK1; upstream component for regulation through the small GTPase Rho5p; may form a complex with Lmo1p that acts as a GEF for Rho5p; interacts with Ino4p; cytoplasmic protein that relocates to mitochondria under oxidative stress; implicated in mitophagy; not an essential protein; DOCK proteins act as guanine nucleotide exchange factors.


ensembl_gene_id: YLR423C
symbol: ATG17
gene_biotype: protein_coding
description:
  Autophagy-related protein 17; Scaffold protein responsible for phagophore assembly site organization; regulatory subunit of an autophagy-specific complex that includes Atg1p and Atg13p; stimulates Atg1p kinase activity; human ortholog RB1CC1/FIP200 interacts with p53, which inhibits autophagy in human cells.


ensembl_gene_id: YLR424W
symbol: SPP382
gene_biotype: protein_coding
description:
  Pre-mRNA-splicing factor SPP382; Essential protein that forms a dimer with Ntr2p; also forms a trimer, with Ntr2p and Prp43p, that is involved in spliceosome disassembly; found also in a multisubunit complex with the splicing factor Clf1p; suppressor of prp38-1 mutation.


ensembl_gene_id: YLR425W
symbol: TUS1
gene_biotype: protein_coding
description:
  Guanine nucleotide exchange factor (GEF) that modulates Rho1p activity; involved in the cell integrity signaling pathway; interacts with Rgl1p; localization of Tus1p to the bed neck is regulated by Rgl1p; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate.


ensembl_gene_id: YLR426W
symbol: TDA5
gene_biotype: protein_coding
description:
  Uncharacterized oxidoreductase TDA5; Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; proposed to be involved in resistance to mechlorethamine and streptozotocin; null mutant sensitive to expression of top1-T722A allele; Belongs to the short-chain dehydrogenases/reductases (SDR) family.


ensembl_gene_id: YLR427W
symbol: MAG2
gene_biotype: protein_coding
description:
  RING-finger protein MAG2; Cytoplasmic protein of unknown function; induced in response to mycotoxin patulin; ubiquitinated protein similar to the human ring finger motif protein RNF10; predicted to be involved in repair of alkylated DNA due to interaction with MAG1.


ensembl_gene_id: YLR428C
symbol: YLR428C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YLR428C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CRN1.


ensembl_gene_id: YLR429W
symbol: CRN1
gene_biotype: protein_coding
description:
  Coronin-like protein; Coronin; cortical actin cytoskeletal component that associates with the Arp2p/Arp3p complex to regulate its activity; plays a role in regulation of actin patch assembly.


ensembl_gene_id: YLR430W
symbol: SEN1
gene_biotype: protein_coding
description:
  Helicase SEN1; ATP-dependent 5' to 3' RNA/DNA and DNA helicase; subunit of the exosome-associated Nrd1p complex that mediates 3' end formation of snRNAs, snoRNAs, CUTs and some mRNAs; helicase-independent role in transcription-coupled repair; coordinates replication with transcription, associating with moving forks and preventing errors that occur when forks encounter transcribed regions; homolog of Senataxin, implicated in Ataxia-Oculomotor Apraxia 2 and a dominant form of juvenile ALS.


ensembl_gene_id: YLR431C
symbol: ATG23
gene_biotype: protein_coding
description:
  Autophagy-related protein 23; Peripheral membrane protein required for autophagy and CVT; required for cytoplasm-to-vacuole targeting (Cvt) pathway and efficient macroautophagy; cycles between the phagophore assembly site (PAS) and non-PAS locations; forms a complex with Atg9p and Atg27p; Belongs to the ATG23 family.


ensembl_gene_id: YLR432W
symbol: IMD3
gene_biotype: protein_coding
description:
  Inosine-5'-monophosphate dehydrogenase 3; Inosine monophosphate dehydrogenase; catalyzes the rate-limiting step in the de novo synthesis of GTP; member of a four-gene family in S. cerevisiae, constitutively expressed; IMD3 has a paralog, IMD4, that arose from the whole genome duplication; Belongs to the IMPDH/GMPR family.


ensembl_gene_id: YLR433C
symbol: CNA1
gene_biotype: protein_coding
description:
  Serine/threonine-protein phosphatase 2B catalytic subunit A1; Calcineurin A; one isoform (the other is Cmp2p) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1; regulates the function of Aly1p alpha-arrestin; CNA1 has a paralog, CMP2, that arose from the whole genome duplication; Belongs to the PPP phosphatase family. PP-2B subfamily.


ensembl_gene_id: YLR434C
symbol: YLR434C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YLR434C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TSR2/YLR435W.


ensembl_gene_id: YLR435W
symbol: TSR2
gene_biotype: protein_coding
description:
  Pre-rRNA-processing protein TSR2; Protein with a potential role in pre-rRNA processing; Belongs to the TSR2 family.


ensembl_gene_id: YLR436C
symbol: ECM30
gene_biotype: protein_coding
description:
  Protein of unknown function; may play a role in cell wall biosynthesis, mutants have abormal relative levels of mannose and glucose and have Gap1p sorting and transport defects; (GFP)-fusion protein localizes to the cytoplasm.


ensembl_gene_id: YLR437C
symbol: DIF1
gene_biotype: protein_coding
description:
  Damage-regulated import facilitator 1; Protein that regulates nuclear localization of Rnr2p and Rnr4p; phosphorylated by Dun1p in response to DNA damage and degraded; N-terminal half shows similarity to S. pombe Spd1 protein; DIF1 has a paralog, SML1, that arose from the whole genome duplication.


ensembl_gene_id: YLR437C-A
symbol: YLR437C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YLR437C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CAR2/YLR438W.


ensembl_gene_id: YLR438C-A
symbol: LSM3
gene_biotype: protein_coding
description:
  U6 snRNA-associated Sm-like protein LSm3; Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; protein increases in abundance and relocalizes from nucleus to cytoplasmic foci upon DNA replication stress.


ensembl_gene_id: YLR438W
symbol: CAR2
gene_biotype: protein_coding
description:
  L-ornithine transaminase (OTAse); catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive; protein abundance increases in response to DNA replication stress; human homolog OAT complements yeast null mutant.


ensembl_gene_id: YLR439W
symbol: MRPL4
gene_biotype: protein_coding
description:
  Mitochondrial ribosomal protein of the large subunit; homolog of prokaryotic L29 ribosomal protein; located at the ribosomal tunnel exit.


ensembl_gene_id: YLR440C
symbol: SEC39
gene_biotype: protein_coding
description:
  Protein transport protein SEC39; Component of the Dsl1p tethering complex; this complex interacts with ER SNAREs Sec20p and Use1p; mediates Sey1p-independent homotypic ER fusion; proposed to be involved in protein secretion; localizes to the ER and nuclear envelope.


ensembl_gene_id: YLR441C
symbol: RPS1A
gene_biotype: protein_coding
description:
  Ribosomal protein 10 (rp10) of the small (40S) subunit; homologous to mammalian ribosomal protein S3A, no bacterial homolog; RPS1A has a paralog, RPS1B, that arose from the whole genome duplication.


ensembl_gene_id: YLR442C
symbol: SIR3
gene_biotype: protein_coding
description:
  Regulatory protein SIR3; Silencing protein; interacts with Sir2p, Sir4p, and histone H3/H4 tails to establish transcriptionally silent chromatin; required for spreading of silenced chromatin; recruited to chromatin through interaction with Rap1p; C-terminus assumes variant winged helix-turn-helix (wH) fold that mediates homodimerization, which is critical for holo-SIR complex loading; required for telomere hypercluster formation in quiescent yeast cells; has paralog ORC1 from whole genome duplication.


ensembl_gene_id: YLR443W
symbol: ECM7
gene_biotype: protein_coding
description:
  Protein ECM7; Putative integral membrane protein with a role in calcium uptake; non-essential protein; mutant has cell wall defects and Ca+ uptake deficiencies; transcription is induced under conditions of zinc deficiency.


ensembl_gene_id: YLR444C
symbol: YLR444C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YLR444C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YLR445W
symbol: GMC2
gene_biotype: protein_coding
description:
  Grand meiotic recombination cluster protein 2; Protein involved in meiotic crossing over; component of the Synaptonemal Complex (SC) along with Ecm11p; required for the efficient loading of the SC transverse filament protein, Zip1p; promotes SUMOylation of Ecm11p; mutants are delayed in meiotic nuclear division and are defective in synaptonemal complex assembly; transcription is regulated by Ume6p and induced in response to alpha factor.


ensembl_gene_id: YLR446W
symbol: YLR446W
gene_biotype: protein_coding
description:
  Putative hexokinase; transcript is upregulated during sporulation and the unfolded protein response; YLR446W is not an essential gene; Belongs to the hexokinase family.


ensembl_gene_id: YLR447C
symbol: VMA6
gene_biotype: protein_coding
description:
  Subunit d of the V0 integral membrane domain of V-ATPase; part of the electrogenic proton pump found in the endomembrane system; required for V1 domain assembly on the vacuolar membrane; the V0 integral membrane domain of vacuolar H+-ATPase (V-ATPase) has five subunits.


ensembl_gene_id: YLR448W
symbol: RPL6B
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L6B; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6B has a paralog, RPL6A, that arose from the whole genome duplication.


ensembl_gene_id: YLR449W
symbol: FPR4
gene_biotype: protein_coding
description:
  FK506-binding protein 4; Peptidyl-prolyl cis-trans isomerase (PPIase); nuclear proline isomerase; affects expression of multiple genes via its role in nucleosome assembly; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones; PPIase domain acts as a transcriptional repressor when tethered to DNA by lexA, and repressor activity is dependent on PPIase activity; contains a nucleoplasmin-like fold and can form pentamers; Belongs to the FKBP-type PPIase family. FKBP3/4 subfamily.


ensembl_gene_id: YLR450W
symbol: HMG2
gene_biotype: protein_coding
description:
  HMG-CoA reductase; converts HMG-CoA to mevalonate, a rate-limiting step in sterol biosynthesis; one of two isozymes; overproduction induces assembly of peripheral ER membrane arrays and short nuclear-associated membrane stacks; forms foci at nuclear periphery upon DNA replication stress; HMG2 has a paralog, HMG1, that arose from the whole genome duplication; human homolog HMGCR can complement yeast hmg2 mutant.


ensembl_gene_id: YLR451W
symbol: LEU3
gene_biotype: protein_coding
description:
  Regulatory protein LEU3; Zinc-knuckle transcription factor, repressor and activator; regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; acts as a repressor in leucine-replete conditions and as an activator in the presence of alpha-isopropylmalate, an intermediate in leucine biosynthesis that accumulates during leucine starvation.


ensembl_gene_id: YLR452C
symbol: SST2
gene_biotype: protein_coding
description:
  Protein SST2; GTPase-activating protein for Gpa1p; regulates desensitization to alpha factor pheromone; also required to prevent receptor-independent signaling of the mating pathway; member of the RGS (regulator of G-protein signaling) family.


ensembl_gene_id: YLR453C
symbol: RIF2
gene_biotype: protein_coding
description:
  Protein that binds to the Rap1p C-terminus; acts synergistically with Rif1p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation; RIF2 has a paralog, ORC4, that arose from the whole genome duplication.


ensembl_gene_id: YLR454W
symbol: FMP27
gene_biotype: protein_coding
description:
  Protein FMP27, mitochondrial; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies.


ensembl_gene_id: YLR455W
symbol: PDP3
gene_biotype: protein_coding
description:
  PWWP domain-containing protein YLR455W; Component of the NuA3b histone acetyltransferase complex; regulates interaction between NuA3b and H3K36me3 at the transcribed regions of genes; contains PWWP domain; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); protein abundance increases in response to DNA replication stress; relocalizes to the cytosol in response to hypoxia.


ensembl_gene_id: YLR456W
symbol: YLR456W
gene_biotype: protein_coding
description:
  Pyridoxamine 5'-phosphate oxidase YLR456W homolog; Protein of unknown function; predicted to encode a pyridoxal 5'-phosphate synthase based on sequence similarity but purified protein does not possess this activity, nor does it bind flavin mononucleotide (FMN); null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2; YLR456W has a paralog, YPR172W, that arose from the whole genome duplication.


ensembl_gene_id: YLR457C
symbol: NBP1
gene_biotype: protein_coding
description:
  NAP1-binding protein; Spindle pole body (SPB) component; required for the insertion of the duplication plaque into the nuclear membrane during SPB duplication; essential for bipolar spindle formation; component of the Mps2p-Bbp1p complex; NBP1 has a paralog, YPR174C, that arose from the whole genome duplication.


ensembl_gene_id: YLR458W
symbol: YLR458W
gene_biotype: protein_coding
description:
  Putative uncharacterized membrane protein YLR458W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential NBP1/YLR457C gene required for mitosis.


ensembl_gene_id: YLR459W
symbol: GAB1
gene_biotype: protein_coding
description:
  GPI transamidase subunit; involved in attachment of glycosylphosphatidylinositol (GPI) anchors to proteins; may have a role in recognition of the attachment signal or of the lipid portion of GPI; Belongs to the PIGU family.


ensembl_gene_id: YLR460C
symbol: YLR460C
gene_biotype: protein_coding
description:
  Uncharacterized protein YLR460C; Member of the quinone oxidoreductase family; up-regulated in response to the fungicide mancozeb; possibly up-regulated by iodine.


ensembl_gene_id: YLR461W
symbol: PAU4
gene_biotype: protein_coding
description:
  Seripauperin-4; Member of the seripauperin multigene family; encoded mainly in subtelomeric regions; SWAT-GFP fusion protein localizes to the endoplasmic reticulum and vacuole, while mCherry fusion localizes to just the vacuole; active during alcoholic fermentation; regulated by anaerobiosis; negatively regulated by oxygen; repressed by heme.


ensembl_gene_id: YLR462W
symbol: YLR462W
gene_biotype: protein_coding
description:
  Putative protein of unknown function with similarity to helicases; YLR462W is within the telomere on the right arm of chromosome XII; Belongs to the helicase family. Yeast subtelomeric Y' repeat subfamily.


ensembl_gene_id: YLR463C
symbol: YLR463C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YLR463C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the uncharacterized ORFs YLR462W and YLR464W.


ensembl_gene_id: YLR464W
symbol: YLR464W
gene_biotype: protein_coding
description:
  Putative protein of unknown function; intron is predicted but not detected experimentally; YLR464W overlaps the verified gene YRF1-4/YLR466W and two dubious ORFs YLR463C and YLR465C.


ensembl_gene_id: YLR465C
symbol: BSC3
gene_biotype: protein_coding
description:
  Putative uncharacterized protein BSC3; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; 100% of YLR465C overlaps the uncharacterized ORF YLR464W and 86% of YLR465C overlaps the verified gene YRF1-4.


ensembl_gene_id: YLR466C-A
symbol: YLR466C-A
gene_biotype: protein_coding
description:
  Putative UPF0479 protein YLR466C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YRF1-4/YLR466W; Belongs to the UPF0479 family.


ensembl_gene_id: YLR466C-B
symbol: YLR466C-B
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YLR466C-B; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YLR466W
symbol: YRF1-4
gene_biotype: protein_coding
description:
  Y' element ATP-dependent helicase protein 1 copy 4; Helicase encoded by the Y' element of subtelomeric regions; highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p.


ensembl_gene_id: YLR467C-A
symbol: YLR467C-A
gene_biotype: protein_coding
description:
  Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YRF1-4/YLR466W.


ensembl_gene_id: YLR467W
symbol: YRF1-5
gene_biotype: protein_coding
description:
  Helicase encoded by the Y' element of subtelomeric regions; highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p.


ensembl_gene_id: YML001W
symbol: YPT7
gene_biotype: protein_coding
description:
  Rab family GTPase; GTP-binding protein of the rab family; required for homotypic fusion event in vacuole inheritance, for endosome-endosome fusion; localizes to sites of contact between the vacuole and mitochondria (vCLAMPs); interacts with the cargo selection/retromer complex for retrograde sorting; similar to mammalian Rab7.


ensembl_gene_id: YML002W
symbol: YML002W
gene_biotype: protein_coding
description:
  UPF0507 protein YML002W; Putative protein of unknown function; expression induced by heat and by calcium shortage; Belongs to the UPF0507 family.


ensembl_gene_id: YML004C
symbol: GLO1
gene_biotype: protein_coding
description:
  Lactoylglutathione lyase; Monomeric glyoxalase I; catalyzes the detoxification of methylglyoxal (a by-product of glycolysis) via condensation with glutathione to produce S-D-lactoylglutathione; expression regulated by methylglyoxal levels and osmotic stress.


ensembl_gene_id: YML005W
symbol: TRM12
gene_biotype: protein_coding
description:
  tRNA wybutosine-synthesizing protein 2; S-adenosylmethionine-dependent methyltransferase; required for wybutosine formation in phenylalanine-accepting tRNA; member of the seven beta-strand family; Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.


ensembl_gene_id: YML006C
symbol: GIS4
gene_biotype: protein_coding
description:
  Protein GIS4; CAAX box containing protein of unknown function; proposed to be involved in the RAS/cAMP signaling pathway.


ensembl_gene_id: YML007C-A
symbol: YML007C-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YML007C-A, mitochondrial; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria.


ensembl_gene_id: YML007W
symbol: YAP1
gene_biotype: protein_coding
description:
  Basic leucine zipper (bZIP) transcription factor; required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus; Yap1p is degraded in the nucleus after the oxidative stress has passed; mediates resistance to cadmium; relative distribution to the nucleus increases upon DNA replication stress; YAP1 has a paralog, CAD1, that arose from the whole genome duplication.


ensembl_gene_id: YML008C
symbol: ERG6
gene_biotype: protein_coding
description:
  Delta(24)-sterol C-methyltransferase; converts zymosterol to fecosterol in the ergosterol biosynthetic pathway by methylating position C-24; localized to lipid particles, the plasma membrane-associated endoplasmic reticulum, and the mitochondrial outer membrane; Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.


ensembl_gene_id: YML009C-A
symbol: YML009C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized membrane protein YML009C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORFs SPT5/YML010W and YML009W-B.


ensembl_gene_id: YML009W-B
symbol: YML009W-B
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YML009W-B; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion mutation confers an increase in Ty1 transposition.


ensembl_gene_id: YML010W
symbol: SPT5
gene_biotype: protein_coding
description:
  Spt4p/5p (DSIF) transcription elongation factor complex subunit; the Spt4/5 complex binds to ssRNA in a sequence-specific manner, and in concert with RNAP I and II has multiple roles regulating transcriptional elongation, RNA processing, quality control, and transcription-coupled repair; interacts with DNA upstream of RNAPII and the non-template strand of the transcription bubble; Spt5p is the only transcription elongation factor conserved in all domains of life.


ensembl_gene_id: YML011C
symbol: RAD33
gene_biotype: protein_coding
description:
  Protein involved in nucleotide excision repair; green fluorescent protein (GFP)-fusion protein localizes to the nucleus.


ensembl_gene_id: YML012C-A
symbol: YML012C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YML012C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SEL1.


ensembl_gene_id: YML012W
symbol: ERV25
gene_biotype: protein_coding
description:
  Endoplasmic reticulum vesicle protein 25; Member of the p24 family involved in ER to Golgi transport; role in misfolded protein quality control; forms a heterotrimeric complex with Erp1, Erp2p, and Emp24.


ensembl_gene_id: YML013W
symbol: UBX2
gene_biotype: protein_coding
description:
  UBX domain-containing protein 2; Bridging factor involved in ER-associated protein degradation (ERAD); bridges the cytosolic Cdc48p-Npl1p-Ufd1p ATPase complex and the membrane associated Ssm4p and Hrd1p ubiquitin ligase complexes; contains a UBX (ubiquitin regulatory X) domain and a ubiquitin-associated (UBA) domain; redistributes from the ER to lipid droplets during the diauxic shift and stationary phase; required for the maintenance of lipid homeostasis.


ensembl_gene_id: YML014W
symbol: TRM9
gene_biotype: protein_coding
description:
  tRNA methyltransferase; catalyzes modification of wobble bases in tRNA anticodons to 2, 5-methoxycarbonylmethyluridine and 5-methoxycarbonylmethyl-2-thiouridine; may act as part of a complex with Trm112p; deletion mutation increases translational infidelity, including amino acid misincorporation and -1 frameshifting, and also confers resistance to zymocin; null mutant displays activation of stress responses.


ensembl_gene_id: YML015C
symbol: TAF11
gene_biotype: protein_coding
description:
  TFIID subunit (40 kDa); involved in RNA polymerase II transcription initiation, similar to histone H3 with atypical histone fold motif of Spt3-like transcription factors; Belongs to the TAF11 family.


ensembl_gene_id: YML016C
symbol: PPZ1
gene_biotype: protein_coding
description:
  Serine/threonine-protein phosphatase PP-Z1; Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance; Belongs to the PPP phosphatase family. PP-Z subfamily.


ensembl_gene_id: YML017W
symbol: PSP2
gene_biotype: protein_coding
description:
  Protein PSP2; Asn rich cytoplasmic protein that contains RGG motifs; high-copy suppressor of group II intron-splicing defects of a mutation in MRS2 and of a conditional mutation in POL1 (DNA polymerase alpha); possible role in mitochondrial mRNA splicing.


ensembl_gene_id: YML018C
symbol: YML018C
gene_biotype: protein_coding
description:
  Uncharacterized vacuolar membrane protein YML018C; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole; physical interaction with Atg27p suggests a possible role in autophagy; YML018C is not an essential gene; relative distribution to the vacuolar membrane decreases upon DNA replication stress; YML018C has a paralog, THI74, that arose from the whole genome duplication; Belongs to the TPT transporter family.


ensembl_gene_id: YML019W
symbol: OST6
gene_biotype: protein_coding
description:
  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST6; Subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes asparagine-linked glycosylation of newly synthesized proteins; similar to and partially functionally redundant with Ost3p; Belongs to the OST3/OST6 family.


ensembl_gene_id: YML021C
symbol: UNG1
gene_biotype: protein_coding
description:
  Uracil-DNA glycosylase; required for repair of uracil in DNA formed by spontaneous cytosine deamination; efficiently excises uracil from single-stranded DNA in vivo; not required for strand-specific mismatch repair; cell-cycle regulated, expressed in late G1; localizes to mitochondria and nucleus.


ensembl_gene_id: YML022W
symbol: APT1
gene_biotype: protein_coding
description:
  Adenine phosphoribosyltransferase; catalyzes the formation of AMP from adenine and 5-phosphoribosylpyrophosphate; involved in the salvage pathway of purine nucleotide biosynthesis; APT1 has a paralog, APT2, that arose from the whole genome duplication.


ensembl_gene_id: YML023C
symbol: NSE5
gene_biotype: protein_coding
description:
  Non-structural maintenance of chromosome element 5; Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair.


ensembl_gene_id: YML024W
symbol: RPS17A
gene_biotype: protein_coding
description:
  Ribosomal protein 51 (rp51) of the small (40s) subunit; homologous to mammalian ribosomal protein S17, no bacterial homolog; RPS17A has a paralog, RPS17B, that arose from the whole genome duplication.


ensembl_gene_id: YML025C
symbol: YML6
gene_biotype: protein_coding
description:
  Mitochondrial ribosomal protein of the large subunit; has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins.


ensembl_gene_id: YML026C
symbol: RPS18B
gene_biotype: protein_coding
description:
  Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18B has a paralog, RPS18A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YML027W
symbol: YOX1
gene_biotype: protein_coding
description:
  Homeobox protein YOX1; Homeobox transcriptional repressor; binds to Mcm1p and to early cell cycle boxes (ECBs) in the promoters of cell cycle-regulated genes expressed in M/G1 phase; expression is cell cycle-regulated; phosphorylated by Cdc28p; relocalizes from nucleus to cytoplasm upon DNA replication stress; YOX1 has a paralog, YHP1, that arose from the whole genome duplication.


ensembl_gene_id: YML028W
symbol: TSA1
gene_biotype: protein_coding
description:
  Peroxiredoxin TSA1; Thioredoxin peroxidase; acts as both ribosome-associated and free cytoplasmic antioxidant; self-associates to form high-molecular weight chaperone complex under oxidative stress; chaperone activity essential for growth in zinc deficiency; required for telomere length maintenance; binds and modulates Cdc19p activity; protein abundance increases, forms cytoplasmic foci during DNA replication stress; TSA1 has a paralog, TSA2, that arose from the whole genome duplication; Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.


ensembl_gene_id: YML029W
symbol: USA1
gene_biotype: protein_coding
description:
  U1 SNP1-associating protein 1; Scaffold subunit of the Hrd1p ubiquitin ligase; also promotes ligase oligomerization; involved in ER-associated protein degradation (ERAD); interacts with the U1 snRNP-specific protein, Snp1p.


ensembl_gene_id: YML030W
symbol: RCF1
gene_biotype: protein_coding
description:
  Respiratory supercomplex factor 1, mitochondrial; Cytochrome c oxidase subunit; required for assembly of the Complex III-Complex IV supercomplex, and for assembly of Cox13p and Rcf2p into cytochrome c oxidase; similar to Rcf2p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; required for growth under hypoxic conditions; member of the hypoxia induced gene family; C. elegans and human orthologs are functional in yeast.


ensembl_gene_id: YML031C-A
symbol: YML031C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized membrane protein YML031C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified ORF NDC1/YML031W.


ensembl_gene_id: YML031W
symbol: NDC1
gene_biotype: protein_coding
description:
  Nucleoporin NDC1; Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication; homologous to human NDC1.


ensembl_gene_id: YML032C
symbol: RAD52
gene_biotype: protein_coding
description:
  DNA repair and recombination protein RAD52; Protein that stimulates strand exchange; stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA; anneals complementary single-stranded DNA; involved in the repair of double-strand breaks in DNA during vegetative growth and meiosis and UV induced sister chromatid recombination; Belongs to the RAD52 family.


ensembl_gene_id: YML034C-A
symbol: YML034C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YML034C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF SRC1/YML034W.


ensembl_gene_id: YML034W
symbol: SRC1
gene_biotype: protein_coding
description:
  Inner nuclear membrane protein; highly enriched at telomeres and subtelomeric regions; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance; SEC1 has a paralog, HEH2, that arose from the whole genome duplication.


ensembl_gene_id: YML035C
symbol: AMD1
gene_biotype: protein_coding
description:
  AMP deaminase; tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia; thought to be involved in regulation of intracellular purine (adenine, guanine, and inosine) nucleotide pools.


ensembl_gene_id: YML036W
symbol: CGI121
gene_biotype: protein_coding
description:
  Component of the EKC/KEOPS complex; EKC/KEOPS complex is required for t6A tRNA modification and telomeric TG1-3 recombination; may have role in transcription; Cgi121p is dispensable for tRNA modification; other complex members are Bud32p, Kae1p, Pcc1p, and Gon7p; Belongs to the CGI121/TPRKB family.


ensembl_gene_id: YML037C
symbol: YML037C
gene_biotype: protein_coding
description:
  Uncharacterized protein YML037C; Putative protein of unknown function; has some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene.


ensembl_gene_id: YML041C
symbol: VPS71
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 71; Nucleosome-binding component of the SWR1 complex; SWR1 exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting.


ensembl_gene_id: YML042W
symbol: CAT2
gene_biotype: protein_coding
description:
  Carnitine O-acetyltransferase, mitochondrial; Carnitine acetyl-CoA transferase; present in both mitochondria and peroxisomes; transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes; Belongs to the carnitine/choline acetyltransferase family.


ensembl_gene_id: YML043C
symbol: RRN11
gene_biotype: protein_coding
description:
  RNA polymerase I-specific transcription initiation factor RRN11; Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p.


ensembl_gene_id: YML046W
symbol: PRP39
gene_biotype: protein_coding
description:
  Pre-mRNA-processing factor 39; U1 snRNP protein involved in splicing; contains multiple tetriatricopeptide repeats.


ensembl_gene_id: YML047C
symbol: PRM6
gene_biotype: protein_coding
description:
  Pheromone-regulated membrane protein 6; Potassium transporter that mediates K+ influx; activates high-affinity Ca2+ influx system (HACS) during mating pheromone response; expression up-regulated in response to alpha factor; regulated by Ste12p during mating; localized to sites of polarized growth; member of a fungal-specific gene family; PRM6 has a paralog, KCH1, that arose from the whole genome duplication; To yeast YJR054w.


ensembl_gene_id: YML047W-A
symbol: YML047W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized membrane protein YML047W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF PRM6/YML047C.


ensembl_gene_id: YML048W
symbol: GSF2
gene_biotype: protein_coding
description:
  Glucose-signaling factor 2; Endoplasmic reticulum (ER) localized integral membrane protein; may promote secretion of certain hexose transporters, including Gal2p; involved in glucose-dependent repression.


ensembl_gene_id: YML049C
symbol: RSE1
gene_biotype: protein_coding
description:
  Pre-mRNA-splicing factor RSE1; Protein involved in pre-mRNA splicing; component of the pre-spliceosome; associates with U2 snRNA; involved in ER to Golgi transport; Belongs to the RSE1 family.


ensembl_gene_id: YML050W
symbol: AIM32
gene_biotype: protein_coding
description:
  Altered inheritance of mitochondria protein 32; Protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss.


