# geneInfo

ensembl_gene_id: YOR086C
symbol: TCB1
gene_biotype: protein_coding
description:
  Tricalbin-1; Lipid-binding ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to plasma membrane and regulate PI4P levels by controlling access of Sac1p phosphatase to its substrate PI4P in PM; contains 3 calcium and lipid binding domains; non-tagged protein also localizes to mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact; TCB1 has a paralog, TCB2, that arose from the whole genome duplication; Belongs to the tricalbin family.


ensembl_gene_id: YOR087W
symbol: YVC1
gene_biotype: protein_coding
description:
  Calcium channel YVC1; Vacuolar cation channel; mediates release of Ca(2+) from the vacuole in response to hyperosmotic shock.


ensembl_gene_id: YOR089C
symbol: VPS21
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 21; Endosomal Rab family GTPase; required for endocytic transport and sorting of vacuolar hydrolases; required for endosomal localization of the CORVET complex; required with YPT52 for MVB biogenesis and sorting; involved in autophagy and ionic stress tolerance; geranylgeranylation required for membrane association; protein abundance increases in response to DNA replication stress; mammalian Rab5 homolog; VPS21 has a paralog, YPT53, that arose from the whole genome duplication.


ensembl_gene_id: YOR090C
symbol: PTC5
gene_biotype: protein_coding
description:
  [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial; Mitochondrial type 2C protein phosphatase (PP2C); involved in regulation of pyruvate dehydrogenase activity by dephosphorylating the serine 133 of the Pda1p subunit; localizes to the intermembrane space and is imported via the presequence pathway and processed by the inner membrane protease (Imp1p-Imp2p); acts in concert with kinases Pkp1p and Pkp2p and phosphatase Ptc6p.


ensembl_gene_id: YOR091W
symbol: TMA46
gene_biotype: protein_coding
description:
  Translation machinery-associated protein 46; Protein of unknown function that associates with translating ribosomes; interacts with GTPase Rbg1p.


ensembl_gene_id: YOR092W
symbol: ECM3
gene_biotype: protein_coding
description:
  Non-essential protein of unknown function; involved in signal transduction and the genotoxic response; induced rapidly in response to treatment with 8-methoxypsoralen and UVA irradiation; relocalizes from ER to cytoplasm upon DNA replication stress; ECM3 has a paralog, YNL095C, that arose from the whole genome duplication.


ensembl_gene_id: YOR093C
symbol: CMR2
gene_biotype: protein_coding
description:
  Uncharacterized protein YOR093C; Putative protein of unknown function; deletion causes sensitivity to unfolded protein response-inducing agents.


ensembl_gene_id: YOR094W
symbol: ARF3
gene_biotype: protein_coding
description:
  Glucose-repressible ADP-ribosylation factor; GTPase of Ras superfamily involved in regulating cell polarity and invasive growth; localizes to dynamic spots at plasma membrane and modulates PtdIns(4,5)P2 levels to facilitate endocytosis; required for localization of endocytic protein Lsb5p to correct cortical site in cells; also has mRNA binding activity; homolog of mammalian Arf6.


ensembl_gene_id: YOR095C
symbol: RKI1
gene_biotype: protein_coding
description:
  Ribose-5-phosphate ketol-isomerase; catalyzes the interconversion of ribose 5-phosphate and ribulose 5-phosphate in the pentose phosphate pathway; participates in pyridoxine biosynthesis.


ensembl_gene_id: YOR096W
symbol: RPS7A
gene_biotype: protein_coding
description:
  Protein component of the small (40S) ribosomal subunit; interacts with Kti11p; deletion causes hypersensitivity to zymocin; homologous to mammalian ribosomal protein S7, no bacterial homolog; RPS7A has a paralog, RPS7B, that arose from the whole genome duplication.


ensembl_gene_id: YOR097C
symbol: YOR097C
gene_biotype: protein_coding
description:
  Uncharacterized protein YOR097C; Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen; YOR097C is not an essential gene.


ensembl_gene_id: YOR098C
symbol: NUP1
gene_biotype: protein_coding
description:
  FG-nucleoporin component of central core of the nuclear pore complex; contributes directly to nucleocytoplasmic transport and maintenance of thenuclear pore complex (NPC) permeability barrier; possible karyopherin release factor that accelerates release of karyopherin-cargo complexes after transport across NPC; both NUP1 and NUP60 are homologous to human NUP153.


ensembl_gene_id: YOR099W
symbol: KTR1
gene_biotype: protein_coding
description:
  Alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; type II membrane protein; member of the KRE2/MNT1 mannosyltransferase family; relocalizes from vacuole to cytoplasm upon DNA replication stress; Belongs to the glycosyltransferase 15 family.


ensembl_gene_id: YOR100C
symbol: CRC1
gene_biotype: protein_coding
description:
  Mitochondrial inner membrane carnitine transporter; required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation; human homolog SLC25A20 complements yeast null mutant; Belongs to the mitochondrial carrier (TC 2.A.29) family.


ensembl_gene_id: YOR101W
symbol: RAS1
gene_biotype: protein_coding
description:
  Ras-like protein 1; GTPase involved in G-protein signaling in adenylate cyclase activation; plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes; relative distribution to the nucleus increases upon DNA replication stress; RAS1 has a paralog, RAS2, that arose from the whole genome duplication.


ensembl_gene_id: YOR102W
symbol: YOR102W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YOR102W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; extensively overlaps essential OST2 gene encoding a subunit of the ER lumen oligosaccharyltransferase complex.


ensembl_gene_id: YOR103C
symbol: OST2
gene_biotype: protein_coding
description:
  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST2; Epsilon subunit of the oligosaccharyltransferase complex; located in the ER lumen; catalyzes asparagine-linked glycosylation of newly synthesized proteins.


ensembl_gene_id: YOR104W
symbol: PIN2
gene_biotype: protein_coding
description:
  [PSI+] induction protein 2; Exomer-dependent cargo protein; induces appearance of [PIN+] prion when overproduced; prion-like domain serves as a retention signal in the trans-Golgi network; predicted to be palmitoylated.


ensembl_gene_id: YOR105W
symbol: YOR105W
gene_biotype: protein_coding
description:
  Uncharacterized protein YOR105W; Protein of unknown function; expressed at both mRNA and protein levels.


ensembl_gene_id: YOR106W
symbol: VAM3
gene_biotype: protein_coding
description:
  Syntaxin-like vacuolar t-SNARE; functions with Vam7p in vacuolar protein trafficking; mediates docking/fusion of late transport intermediates with the vacuole; has an acidic di-leucine sorting signal and C-terminal transmembrane region.


ensembl_gene_id: YOR107W
symbol: RGS2
gene_biotype: protein_coding
description:
  Negative regulator of glucose-induced cAMP signaling; directly activates the GTPase activity of the heterotrimeric G protein alpha subunit Gpa2p.


ensembl_gene_id: YOR108C-A
symbol: YOR108C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YOR108C-A; Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching.


ensembl_gene_id: YOR108W
symbol: LEU9
gene_biotype: protein_coding
description:
  Alpha-isopropylmalate synthase II (2-isopropylmalate synthase); catalyzes the first step in the leucine biosynthesis pathway; the minor isozyme, responsible for the residual alpha-IPMS activity detected in a leu4 null mutant; LEU9 has a paralog, LEU4, that arose from the whole genome duplication; Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.


ensembl_gene_id: YOR109W
symbol: INP53
gene_biotype: protein_coding
description:
  Phosphatidylinositol 4,5-bisphosphate 5-phosphatase; Polyphosphatidylinositol phosphatase; dephosphorylates multiple phosphatidylinositol phosphates; involved in trans Golgi network-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; contains Sac1 and 5-ptase domains; INP53 has a paralog, INP52, that arose from the whole genome duplication; Belongs to the synaptojanin family.


ensembl_gene_id: YOR110W
symbol: TFC7
gene_biotype: protein_coding
description:
  RNA pol III transcription initiation factor complex (TFIIIC) subunit; part of the TauA globular domain of TFIIIC that binds DNA at the BoxA promoter sites of tRNA and similar genes; TFC7 has a paralog, YNL108C, that arose from the whole genome duplication.


ensembl_gene_id: YOR112W
symbol: CEX1
gene_biotype: protein_coding
description:
  Cytoplasmic export protein 1; Component of nuclear aminoacylation-dependent tRNA export pathway; cytoplasmic; interacts with nuclear pore component Nup116p; copurifies with tRNA export receptors Los1p and Msn5p, as well as eIF-1a; required for activation of RAN GTPase Gsp1p and dissociation of receptor-tRNA-Gsp1p export complex; recruits Rna1p from cytoplasm to NPC, facilitates Rna1p activation of Gsp1p GTPase activity by enabling Rna1p to gain access to Gsp1p-GTP bound to export receptor tRNA complex.


ensembl_gene_id: YOR113W
symbol: AZF1
gene_biotype: protein_coding
description:
  Asparagine-rich zinc finger protein AZF1; Zinc-finger transcription factor; involved in diauxic shift; in the presence of glucose, activates transcription of genes involved in growth and carbon metabolism; in nonfermentable carbon sources, activates transcription of genes involved in maintenance of cell wall integrity; relocalizes to the cytosol in response to hypoxia.


ensembl_gene_id: YOR115C
symbol: TRS33
gene_biotype: protein_coding
description:
  Core component of TRAPP complexes I, II and IV; transport protein particle (TRAPP) complexes are related multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p, regulating ER-Golgi traffic (TRAPPI), intra-Golgi traffic (TRAPPII), endosome-Golgi traffic (TRAPPII and III) and autophagy (TRAPPIII, and IV); proposed subunit of a novel complex, TRAPPIV, that may function redundantly with TRAPPIII as a GEF that activates Ypt1 during autophagy; Belongs to the TRAPP small subunits family. BET3 subfamily.


ensembl_gene_id: YOR116C
symbol: RPO31
gene_biotype: protein_coding
description:
  RNA polymerase III largest subunit C160; part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21; Belongs to the RNA polymerase beta' chain family.


ensembl_gene_id: YOR117W
symbol: RPT5
gene_biotype: protein_coding
description:
  ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; recruited to the GAL1-10 promoter region upon induction of transcription; similar to human TBP1.


ensembl_gene_id: YOR118W
symbol: RTC5
gene_biotype: protein_coding
description:
  Restriction of telomere capping protein 5; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; null mutation suppresses cdc13-1 temperature sensitivity.


ensembl_gene_id: YOR119C
symbol: RIO1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase RIO1; Serine kinase involved in cell cycle regulation and rDNA integrity; associated with late pre-40S particles via its conserved C-terminal domain and participates in late 40S biogenesis; association with pre-40S particles regulated by its catalytic ATPase site and likely occurs after the release of Rio2p from these particles; involved in cell cycle progression and processing of the 20S pre-rRNA into mature 18S rRNA; phosphorylates Rpa43p in anaphase to remove Pol I from rDNA.


ensembl_gene_id: YOR120W
symbol: GCY1
gene_biotype: protein_coding
description:
  Glycerol 2-dehydrogenase (NADP(+)); Glycerol dehydrogenase; involved in an alternative pathway for glycerol catabolism used under microaerobic conditions; also has mRNA binding activity; member of the aldo-keto reductase (AKR) family; human homolog AKR1B1 can complement yeast null mutant; protein abundance increases in response to DNA replication stress; GCY1 has a paralog, YPR1, that arose from the whole genome duplication.


ensembl_gene_id: YOR121C
symbol: YOR121C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YOR121C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene GCY1/YOR120W.


ensembl_gene_id: YOR122C
symbol: PFY1
gene_biotype: protein_coding
description:
  Profilin; binds actin, phosphatidylinositol 4,5-bisphosphate, and polyproline regions; involved in cytoskeleton organization; required for normal timing of actin polymerization in response to thermal stress; protein abundance increases in response to DNA replication stress; highly conserved protein; human PFN1 (profilin 1) complements temperature sensitive pfy1 mutants, PFN1 mutations are a rare cause of ALS.


ensembl_gene_id: YOR123C
symbol: LEO1
gene_biotype: protein_coding
description:
  RNA polymerase-associated protein LEO1; Component of the Paf1 complex; which associates with RNA polymerase II and is involved in histone methylation; plays a role in regulating Ty1 transposition; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay.


ensembl_gene_id: YOR124C
symbol: UBP2
gene_biotype: protein_coding
description:
  Ubiquitin carboxyl-terminal hydrolase 2; Ubiquitin-specific protease; removes ubiquitin from ubiquitinated proteins; controls K63 homeostasis during oxidative stress; deubiquitinates Rsp5p and is required for MVB sorting of membrane proteins; can cleave polyubiquitin and has isopeptidase activity.


ensembl_gene_id: YOR125C
symbol: CAT5
gene_biotype: protein_coding
description:
  5-demethoxyubiquinone hydroxylase, mitochondrial; Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation; Belongs to the COQ7 family.


ensembl_gene_id: YOR126C
symbol: IAH1
gene_biotype: protein_coding
description:
  Isoamyl acetate-hydrolyzing esterase; required in balance with alcohol acetyltransferase to maintain optimal amounts of isoamyl acetate, which is particularly important in sake brewing; Belongs to the 'GDSL' lipolytic enzyme family. IAH1 subfamily.


ensembl_gene_id: YOR127W
symbol: RGA1
gene_biotype: protein_coding
description:
  GTPase-activating protein for polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; relocalizes from bud neck to cytoplasm upon DNA replication stress; RGA1 has a paralog, RGA2, that arose from the whole genome duplication.


ensembl_gene_id: YOR128C
symbol: ADE2
gene_biotype: protein_coding
description:
  Phosphoribosylaminoimidazole carboxylase; catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway; red pigment accumulates in mutant cells deprived of adenine.


ensembl_gene_id: YOR129C
symbol: AFI1
gene_biotype: protein_coding
description:
  ARF3-interacting protein 1; Arf3p polarization-specific docking factor; required for the polarized distribution of the ADP-ribosylation factor, Arf3p; participates in polarity development and maintenance of a normal haploid budding pattern; interacts with Cnm7p.


ensembl_gene_id: YOR130C
symbol: ORT1
gene_biotype: protein_coding
description:
  Ornithine transporter of the mitochondrial inner membrane; exports ornithine from mitochondria as part of arginine biosynthesis; functionally complemented by human ortholog, SLC25A15, which is associated with hyperammonaemia-hyperornithinaemia-homocitrullinuria (HHH) syndrome, but HHH-associated variants fail to complement.


ensembl_gene_id: YOR131C
symbol: YOR131C
gene_biotype: protein_coding
description:
  Uncharacterized hydrolase YOR131C; Putative haloacid dehalogenase-like hydrolase; non-essential gene; overexpression causes a cell cycle delay or arrest; protein abundance increases in response to DNA replication stress; Belongs to the HAD-like hydrolase superfamily.


ensembl_gene_id: YOR132W
symbol: VPS17
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 17; Subunit of the membrane-associated retromer complex; essential for endosome-to-Golgi retrograde protein transport; peripheral membrane protein that assembles onto the membrane with Vps5p to promote vesicle formation; required for recruiting the retromer complex to the endosome membranes; Belongs to the VPS17 family.


ensembl_gene_id: YOR133W
symbol: EFT1
gene_biotype: protein_coding
description:
  Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication.


ensembl_gene_id: YOR134W
symbol: BAG7
gene_biotype: protein_coding
description:
  Rho-GTPase-activating protein BAG7; Rho GTPase activating protein (RhoGAP); stimulates the intrinsic GTPase activity of Rho1p, which plays a bud growth by regulating actin cytoskeleton organization and cell wall biosynthesis, resulting in the downregulation of Rho1p; structurally and functionally related to Sac7p; BAG7 has a paralog, SAC7, that arose from the whole genome duplication.


ensembl_gene_id: YOR135C
symbol: IRC14
gene_biotype: protein_coding
description:
  Putative increased recombination centers protein 14; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YOR136W; null mutant displays increased levels of spontaneous Rad52 foci.


ensembl_gene_id: YOR136W
symbol: IDH2
gene_biotype: protein_coding
description:
  Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase; complex catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle; phosphorylated; Belongs to the isocitrate and isopropylmalate dehydrogenases family.


ensembl_gene_id: YOR137C
symbol: SIA1
gene_biotype: protein_coding
description:
  Protein of unassigned function; involved in activation of the Pma1p plasma membrane H+-ATPase by glucose; contains peptide signal for membrane localization.


ensembl_gene_id: YOR138C
symbol: RUP1
gene_biotype: protein_coding
description:
  UBA domain-containing protein RUP1; Protein that regulates ubiquitination of Rsp5p; has a WW domain consensus motif of PPPSY (residues 131-135) that mediates binding of Rsp5p to Ubp2p; contains an UBA domain; relative distribution to the nucleus increases upon DNA replication stress.


ensembl_gene_id: YOR139C
symbol: YOR139C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YOR139C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SFL1/YOR140W.


ensembl_gene_id: YOR140W
symbol: SFL1
gene_biotype: protein_coding
description:
  Flocculation suppression protein; Transcriptional repressor and activator; involved in repression of flocculation-related genes, and activation of stress responsive genes; has direct role in INO1 transcriptional memory; negatively regulated by cAMP-dependent protein kinase A subunit Tpk2p; premature stop codon (C1430T, Q477-stop) in SK1 background is linked to the aggressively invasive phenotype of SK1 relative to BY4741 (S288C).


ensembl_gene_id: YOR141C
symbol: ARP8
gene_biotype: protein_coding
description:
  Actin-like protein ARP8; Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes; has mRNA binding activity.


ensembl_gene_id: YOR142W
symbol: LSC1
gene_biotype: protein_coding
description:
  Alpha subunit of succinyl-CoA ligase; succinyl-CoA ligase is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate; phosphorylated.


ensembl_gene_id: YOR143C
symbol: THI80
gene_biotype: protein_coding
description:
  Thiamine pyrophosphokinase; phosphorylates thiamine to produce the coenzyme thiamine pyrophosphate (thiamine diphosphate).


ensembl_gene_id: YOR144C
symbol: ELG1
gene_biotype: protein_coding
description:
  Telomere length regulation protein ELG1; Subunit of an alternative replication factor C complex; important for DNA replication and genome integrity; suppresses spontaneous DNA damage; involved in homologous recombination-mediated repair and telomere homeostasis; required for PCNA (Pol30p) unloading during DNA replication; Belongs to the ELG1 family.


ensembl_gene_id: YOR145C
symbol: PNO1
gene_biotype: protein_coding
description:
  Pre-rRNA-processing protein PNO1; Essential nucleolar protein required for pre-18S rRNA processing; interacts with Dim1p, an 18S rRNA dimethyltransferase, and also with Nob1p, which is involved in proteasome biogenesis; contains a KH domain.


ensembl_gene_id: YOR146W
symbol: YOR146W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YOR146W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene PNO1/YOR145C.


ensembl_gene_id: YOR147W
symbol: MDM32
gene_biotype: protein_coding
description:
  Mitochondrial distribution and morphology protein 32; Mitochondrial inner membrane protein with similarity to Mdm31p; required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MDM10, MDM12, and MDM34; variation between SK1 and S288C at residues 182 and 262 impacts invasive growth and mitochondrial network structure; Belongs to the MDM31/MDM32 family.


ensembl_gene_id: YOR148C
symbol: SPP2
gene_biotype: protein_coding
description:
  Pre-mRNA-splicing factor SPP2; Essential protein that promotes the first step of splicing; required for the final stages of spliceosome maturation and activation; interacts with Prp2p, which may release Spp2p from the spliceosome following the first cleavage reaction; stimulates Prp2p ATPase activity; Belongs to the SPP2 family.


ensembl_gene_id: YOR149C
symbol: SMP3
gene_biotype: protein_coding
description:
  GPI mannosyltransferase 4; Alpha 1,2-mannosyltransferase; involved in glycosyl phosphatidyl inositol (GPI) biosynthesis; required for addition of the fourth, side branching mannose to the GPI core structure.


ensembl_gene_id: YOR151C
symbol: RPB2
gene_biotype: protein_coding
description:
  RNA polymerase II second largest subunit B150; part of central core; similar to bacterial beta subunit.


ensembl_gene_id: YOR152C
symbol: ATG40
gene_biotype: protein_coding
description:
  Autophagy-related protein 40; Autophagy receptor with a role in endoplasmic reticulum degradation; involved specifically in autophagy of cortical and cytoplasmic ER in response to nitrogen starvation or rapamycin treatment; localizes to the cortical and cytoplasmic ER; similar to human FAM134B, which is also involved in ER autophagy and is associated with sensory neuropathy.


ensembl_gene_id: YOR153W
symbol: PDR5
gene_biotype: protein_coding
description:
  Pleiotropic ABC efflux transporter of multiple drugs; Plasma membrane ATP-binding cassette (ABC) transporter; multidrug transporter actively regulated by Pdr1p; also involved in steroid transport, cation resistance, and cellular detoxification during exponential growth; PDR5 has a paralog, PDR15, that arose from the whole genome duplication.


ensembl_gene_id: YOR154W
symbol: SLP1
gene_biotype: protein_coding
description:
  Uncharacterized protein SLP1; Glycosylated integral ER membrane protein of unknown function; forms an ER-membrane associated protein complex with Emp65p; member of the SUN-like family of proteins; genetic interactions suggest a role in folding of ER membrane proteins; required for nuclear envelope localization of Mps3p.


ensembl_gene_id: YOR155C
symbol: ISN1
gene_biotype: protein_coding
description:
  IMP-specific 5'-nucleotidase 1; Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase; catalyzes the breakdown of IMP to inosine; responsible for production of nicotinamide riboside and nicotinic acid riboside; expression positively regulated by nicotinic acid and glucose availability; does not show similarity to known 5'-nucleotidases from other organisms; Belongs to the ISN1 family.


ensembl_gene_id: YOR156C
symbol: NFI1
gene_biotype: protein_coding
description:
  SUMO E3 ligase; catalyzes sumoylation of Yku70p/80p and Sir4p promoting telomere anchoring to the nuclear envelope and regulating telomerase activity; DNA-bound form catalyzes a DNA-damaged triggered sumoylation wave resulting in multisite modification of several DNA repair proteins, enhancing interactions between these proteins and accelerating repair; sumoylates Cse4p, a prerequisite for STUbL-mediated Ub-dependent degradation; role in telomere length maintenance; Belongs to the PIAS family.


ensembl_gene_id: YOR157C
symbol: PUP1
gene_biotype: protein_coding
description:
  Beta 2 subunit of the 20S proteasome; endopeptidase with trypsin-like activity that cleaves after basic residues; synthesized as a proprotein before being proteolytically processed for assembly into 20S particle; human homolog is subunit Z.


ensembl_gene_id: YOR158W
symbol: PET123
gene_biotype: protein_coding
description:
  Mitochondrial ribosomal protein of the small subunit; PET123 exhibits genetic interactions with PET122, which encodes a COX3 mRNA-specific translational activator.


ensembl_gene_id: YOR159C
symbol: SME1
gene_biotype: protein_coding
description:
  Small nuclear ribonucleoprotein E; Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E.


ensembl_gene_id: YOR160W
symbol: MTR10
gene_biotype: protein_coding
description:
  mRNA transport regulator MTR10; Nuclear import receptor; mediates the nuclear localization of proteins involved in mRNA-nucleus export; promotes dissociation of mRNAs from the nucleus-cytoplasm mRNA shuttling protein Npl3p; required for retrograde import of mature tRNAs; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress.


ensembl_gene_id: YOR161C
symbol: PNS1
gene_biotype: protein_coding
description:
  Protein of unknown function; has similarity to Torpedo californica tCTL1p, which is postulated to be a choline transporter, neither null mutation nor overexpression affects choline transport; Belongs to the CTL (choline transporter-like) family.


ensembl_gene_id: YOR161C-C
symbol: YOR161C-C
gene_biotype: protein_coding
description:
  Uncharacterized protein YOR161C-C; Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching.


ensembl_gene_id: YOR161W-A
symbol: YOR161W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YOR161W-A; Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching.


ensembl_gene_id: YOR161W-B
symbol: YOR161W-B
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YOR161W-B; Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching.


ensembl_gene_id: YOR162C
symbol: YRR1
gene_biotype: protein_coding
description:
  Zn2-Cys6 zinc-finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes; YRR1 has a paralog, PDR8, that arose from the whole genome duplication.


ensembl_gene_id: YOR163W
symbol: DDP1
gene_biotype: protein_coding
description:
  Diphosphoinositol polyphosphate phosphohydrolase DDP1; Polyphosphate phosphatase; hydrolyzes diphosphorylated inositol polyphosphates and diadenosine polyphosphates; high specificity for diadenosine hexa- and pentaphosphates; contains endopolyphosphatase activity with a high affinity for polyphosphates, an activity also observed for its human DIPP homologs; possesses mRNA decapping activity; nudix hydrolase family member; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YOR164C
symbol: GET4
gene_biotype: protein_coding
description:
  Protein involved in inserting tail-anchored proteins into ER membranes; forms a complex with Mdy2p; highly conserved across species and homologous to human gene C7orf20.


ensembl_gene_id: YOR165W
symbol: SEY1
gene_biotype: protein_coding
description:
  Protein SEY1; Dynamin-like GTPase that mediates homotypic ER fusion; has a role in ER morphology; interacts physically and genetically with Yop1p and Rtn1p; functional ortholog of the human atlastin ATL1, defects in which cause a form of the human disease hereditary spastic paraplegia; homolog of Arabidopsis RHD3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. RHD3 subfamily.


ensembl_gene_id: YOR166C
symbol: SWT1
gene_biotype: protein_coding
description:
  Transcriptional protein SWT1; RNA endoribonuclease involved in perinuclear mRNP quality control; involved in perinuclear mRNP quality control via the turnover of aberrant, unprocessed pre-mRNAs; interacts with subunits of THO/TREX, TREX-2, and RNA polymerase II; contains a PIN (PilT N terminus) domain; Belongs to the SWT1 family.


ensembl_gene_id: YOR167C
symbol: RPS28A
gene_biotype: protein_coding
description:
  Protein component of the small (40S) ribosomal subunit; has an extraribosomal function in regulation of RPS28B, in which Rps28Ap binds to a decapping complex via Edc3p, which then binds to RPS28B mRNA leading to its decapping and degradation; homologous to mammalian ribosomal protein S28, no bacterial homolog; RPS28A has a paralog, RPS28B, that arose from the whole genome duplication.


ensembl_gene_id: YOR168W
symbol: GLN4
gene_biotype: protein_coding
description:
  Glutamine--tRNA ligase; Glutamine tRNA synthetase; monomeric class I tRNA synthetase that catalyzes the specific glutaminylation of tRNA(Gln); N-terminal domain proposed to be involved in enzyme-tRNA interactions; Belongs to the class-I aminoacyl-tRNA synthetase family.


ensembl_gene_id: YOR169C
symbol: YOR169C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YOR169C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene GLN4/YOR168W.


ensembl_gene_id: YOR170W
symbol: YOR170W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YOR170W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene LCB4.


ensembl_gene_id: YOR171C
symbol: LCB4
gene_biotype: protein_coding
description:
  Sphingoid long-chain base kinase; responsible for synthesis of long-chain base phosphates, which function as signaling molecules, regulates synthesis of ceramide from exogenous long-chain bases, localizes to the Golgi and late endosomes; LCB4 has a paralog, LCB5, that arose from the whole genome duplication.


ensembl_gene_id: YOR172W
symbol: YRM1
gene_biotype: protein_coding
description:
  Zinc finger transcription factor involved in multidrug resistance; Zn(2)-Cys(6) zinc finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrr1p, acting on an overlapping set of target genes.


ensembl_gene_id: YOR173W
symbol: DCS2
gene_biotype: protein_coding
description:
  Inactive diphosphatase DCS2; m(7)GpppX pyrophosphatase regulator; non-essential, stress induced regulatory protein; modulates m7G-oligoribonucleotide metabolism; inhibits Dcs1p; regulated by Msn2p, Msn4p, and the Ras-cAMP-cAPK signaling pathway; mutant has increased aneuploidy tolerance; DCS2 has a paralog, DCS1, that arose from the whole genome duplication; Belongs to the HIT family.


ensembl_gene_id: YOR175C
symbol: ALE1
gene_biotype: protein_coding
description:
  Broad-specificity lysophospholipid acyltransferase; part of MBOAT family of membrane-bound O-acyltransferases; key component of Lands cycle; may have role in fatty acid exchange at sn-2 position of mature glycerophospholipids; Belongs to the membrane-bound acyltransferase family.


ensembl_gene_id: YOR176W
symbol: HEM15
gene_biotype: protein_coding
description:
  Ferrochelatase; a mitochondrial inner membrane protein, catalyzes insertion of ferrous iron into protoporphyrin IX, the eighth and final step in the heme biosynthetic pathway; human homolog FECH can complement yeast mutant and allow growth of haploid null after sporulation of a heterozygous diploid.


ensembl_gene_id: YOR177C
symbol: MPC54
gene_biotype: protein_coding
description:
  Component of the meiotic outer plaque; a membrane-organizing center which is assembled on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane; potential Cdc28p substrate.


ensembl_gene_id: YOR178C
symbol: GAC1
gene_biotype: protein_coding
description:
  Regulatory subunit for Glc7p type-1 protein phosphatase (PP1); tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock; GAC1 has a paralog, PIG1, that arose from the whole genome duplication.


ensembl_gene_id: YOR179C
symbol: SYC1
gene_biotype: protein_coding
description:
  Protein SYC1; Subunit of the APT subcomplex of cleavage and polyadenylation factor; may have a role in 3' end formation of both polyadenylated and non-polyadenylated RNAs; SYC1 has a paralog, YSH1, that arose from the whole genome duplication.


ensembl_gene_id: YOR180C
symbol: DCI1
gene_biotype: protein_coding
description:
  Peroxisomal protein; identification as a delta(3,5)-delta(2,4)-dienoyl-CoA isomerase involved in fatty acid metabolism is disputed; DCI1 has a paralog, ECI1, that arose from the whole genome duplication.


ensembl_gene_id: YOR181W
symbol: LAS17
gene_biotype: protein_coding
description:
  Proline-rich protein LAS17; Actin assembly factor; C-terminal WCA domain activates Arp2/3 complex-mediated nucleation of branched actin filaments, polyproline domain nucleates actin filaments independent of Arp2/3; mutants are defective in endocytosis, bud site selection, cytokinesis; human homolog WAS (Wiskott-Aldrich Syndrome) implicated in severe immunodeficiency; human WAS complements yeast null mutant, but only in presence of WIPF1, which mediates localization of WAS to cortical patches.


ensembl_gene_id: YOR182C
symbol: RPS30B
gene_biotype: protein_coding
description:
  Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S30, no bacterial homolog; RPS30B has a paralog, RPS30A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YOR184W
symbol: SER1
gene_biotype: protein_coding
description:
  3-phosphoserine aminotransferase; catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p; protein abundance increases in response to DNA replication stress; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.


ensembl_gene_id: YOR185C
symbol: GSP2
gene_biotype: protein_coding
description:
  GTP-binding nuclear protein GSP2/CNR2; GTP binding protein (mammalian Ranp homolog); involved in the maintenance of nuclear organization, RNA processing and transport; interacts with Kap121p, Kap123p and Pdr6p (karyophilin betas); not required for viability; protein abundance increases in response to DNA replication stress; GSP2 has a paralog, GSP1, that arose from the whole genome duplication; Belongs to the small GTPase superfamily. Ran family.


ensembl_gene_id: YOR186C-A
symbol: YOR186C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YOR186C-A; Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching.


ensembl_gene_id: YOR186W
symbol: YOR186W
gene_biotype: protein_coding
description:
  Putative protein of unknown function; proper regulation of expression during heat stress is sphingolipid-dependent; mCherry fusion protein localizes to the vacuole; YOR186W has a paralog, YLR297W, that arose from the whole genome duplication.


ensembl_gene_id: YOR187W
symbol: TUF1
gene_biotype: protein_coding
description:
  Mitochondrial translation elongation factor Tu (EF-Tu); involved in fundamental pathway of mtDNA homeostasis; comprises both GTPase and guanine nucleotide exchange factor activities, while these activities are found in separate proteins in S. pombe and humans; rare mutations in human mitochondrial elongation factor Tu (EFTu) associated with severe lactic acidosis, rapidly progressive fatal encephalopathy, severe infantile macrocystic leukodystrophy with micropolygyria.


ensembl_gene_id: YOR188W
symbol: MSB1
gene_biotype: protein_coding
description:
  Morphogenesis-related protein MSB1; Protein of unknown function; may be involved in positive regulation of 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway; multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42, and of mutations in BEM4; potential Cdc28p substrate; relocalizes from bud neck to cytoplasm upon DNA replication stress.


ensembl_gene_id: YOR189W
symbol: IES4
gene_biotype: protein_coding
description:
  Ino eighty subunit 4; Component of the INO80 chromatiin remodeling complex; target of the Mec1p/Tel1p DNA damage signaling pathway; proposed to link chromatin remodeling to replication checkpoint responses.


ensembl_gene_id: YOR190W
symbol: SPR1
gene_biotype: protein_coding
description:
  Sporulation-specific exo-1,3-beta-glucanase; contributes to ascospore thermoresistance; SPR1 has a paralog, EXG1, that arose from the whole genome duplication; Belongs to the glycosyl hydrolase 5 (cellulase A) family.


ensembl_gene_id: YOR191W
symbol: ULS1
gene_biotype: protein_coding
description:
  ATP-dependent helicase ULS1; Swi2/Snf2-related translocase, SUMO-Targeted Ubiquitin Ligase (STUbL); required for maintenance of NHEJ inhibition at telomeres; functions at telomeres to translocate and ubiquitinylate poly-sumoylated Rap1p for proteosomal degradation; plays role in antagonizing silencing during mating-type switching; only known STUbL with a translocase activity; contains RING finger domain; relocalizes from nucleus to cytoplasm upon DNA replication stress.


ensembl_gene_id: YOR192C
symbol: THI72
gene_biotype: protein_coding
description:
  Transporter of thiamine or related compound; contributes to uptake of 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (acadesine); shares sequence similarity with Thi7p.


ensembl_gene_id: YOR192C-C
symbol: YOR192C-C
gene_biotype: protein_coding
description:
  Uncharacterized protein YOR192C-C; Putative protein of unknown function; identified by expression profiling and mass spectrometry.


ensembl_gene_id: YOR193W
symbol: PEX27
gene_biotype: protein_coding
description:
  Peripheral peroxisomal membrane protein; involved in controlling peroxisome size and number, interacts with Pex25p; PEX27 has a paralog, PEX25, that arose from the whole genome duplication.


ensembl_gene_id: YOR194C
symbol: TOA1
gene_biotype: protein_coding
description:
  TFIIA large subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; required, along with Toa2p, for ribosomal protein gene transcription in vivo; homologous to largest and second largest subunits of human and Drosophila TFIIA; Belongs to the TFIIA subunit 1 family.


ensembl_gene_id: YOR195W
symbol: SLK19
gene_biotype: protein_coding
description:
  Kinetochore-associated protein; required for chromosome segregation and kinetochore clustering; required for normal segregation of chromosomes in meiosis and mitosis; component of the FEAR regulatory network, which promotes Cdc14p release from the nucleolus during anaphase; potential Cdc28p substrate.


ensembl_gene_id: YOR196C
symbol: LIP5
gene_biotype: protein_coding
description:
  Lipoyl synthase, mitochondrial; Protein involved in biosynthesis of the coenzyme lipoic acid; has similarity to E. coli lipoic acid synthase; Belongs to the radical SAM superfamily. Lipoyl synthase family.


ensembl_gene_id: YOR197W
symbol: MCA1
gene_biotype: protein_coding
description:
  Metacaspase-1; Ca2+-dependent cysteine protease; may cleave specific substrates during the stress response; regulates apoptosis upon H2O2 treatment; required for clearance of insoluble protein aggregates during normal growth; implicated in cell cycle dynamics and lifespan extension; undergoes autocatalytic processing; similar to mammalian metacaspases, but exists as a monomer due to an extra pair of anti-parallel beta-strands that block potential dimerization; Belongs to the peptidase C14B family.


ensembl_gene_id: YOR198C
symbol: BFR1
gene_biotype: protein_coding
description:
  Nuclear segregation protein BFR1; Component of mRNP complexes associated with polyribosomes; involved in localization of mRNAs to P bodies; implicated in secretion and nuclear segregation; multicopy suppressor of BFA (Brefeldin A) sensitivity.


ensembl_gene_id: YOR199W
symbol: YOR199W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YOR199W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YOR200W
symbol: YOR200W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YOR200W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRM1/YOR201c.


ensembl_gene_id: YOR201C
symbol: MRM1
gene_biotype: protein_coding
description:
  rRNA methyltransferase 1, mitochondrial; Ribose methyltransferase; modifies a functionally critical, conserved nucleotide in mitochondrial 21S rRNA; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.


ensembl_gene_id: YOR202W
symbol: HIS3
gene_biotype: protein_coding
description:
  Imidazoleglycerol-phosphate dehydratase; catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p.


ensembl_gene_id: YOR203W
symbol: YOR203W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YOR203W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential DED1 gene required for translation initiation.


ensembl_gene_id: YOR204W
symbol: DED1
gene_biotype: protein_coding
description:
  ATP-dependent DEAD (Asp-Glu-Ala-Asp)-box RNA helicase; required for translation initiation of all yeast mRNAs; binds to mRNA cap-associated factors, and binding stimulates Ded1p RNA-dependent ATPase activity; mutation in human homolog DBY is associated with male infertility; human homolog DDX3X complements ded1 null mutation; DED1 has a paralog, DBP1, that arose from the whole genome duplication.


ensembl_gene_id: YOR205C
symbol: GEP3
gene_biotype: protein_coding
description:
  Genetic interactor of prohibitins 3, mitochondrial; Protein required for mitochondrial ribosome small subunit biogenesis; null mutant is defective in respiration and in maturation of 15S rRNA; protein is localized to the mitochondrial inner membrane; null mutant interacts synthetically with prohibitin (Phb1p); Belongs to the TRAFAC class YlqF/YawG GTPase family. GEP3 subfamily.


ensembl_gene_id: YOR206W
symbol: NOC2
gene_biotype: protein_coding
description:
  Nucleolar complex protein 2; Protein involved in ribosome biogenesis; forms a nucleolar complex with Mak21p that binds to 90S and 66S pre-ribosomes; forms a nuclear complex with Noc3p that binds to 66S pre-ribosomes; both complexes mediate intranuclear transport of ribosomal precursors; acts as part of a Mak21p-Noc2p-Rrp5p module that associates with nascent pre-rRNA during transcription and has a role in bigenesis of the large ribosomal subunit.


ensembl_gene_id: YOR207C
symbol: RET1
gene_biotype: protein_coding
description:
  Second-largest subunit of RNA polymerase III; RNA polymerase III is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs.


ensembl_gene_id: YOR208W
symbol: PTP2
gene_biotype: protein_coding
description:
  Tyrosine-protein phosphatase 2; Nuclear phosphotyrosine-specific phosphatase involved in osmosensing; involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; with Msg5p co-regulates the calcium signaling pathway.


ensembl_gene_id: YOR209C
symbol: NPT1
gene_biotype: protein_coding
description:
  Nicotinate phosphoribosyltransferase; acts in the salvage pathway of NAD+ biosynthesis; required for silencing at rDNA and telomeres and has a role in silencing at mating-type loci; localized to the nucleus.


ensembl_gene_id: YOR211C
symbol: MGM1
gene_biotype: protein_coding
description:
  Mitochondrial GTPase, present in complex with Ugo1p and Fzo1p; required for mitochondrial morphology, fusion, and genome maintenance; promotes membrane bending; exists as long and short form with different distributions; ratio of long to short forms is regulated by Psd1p; homolog of human OPA1 involved in autosomal dominant optic atrophy.


ensembl_gene_id: YOR212W
symbol: STE4
gene_biotype: protein_coding
description:
  G protein beta subunit; forms a dimer with Ste18p to activate mating signaling pathway, forms heterotrimer with Gpa1p and Ste18p to dampen signaling; pheromone-induced phosphorylation plays critical role in chemotropism; may recruit Rho1p to polarized growth site during mating; contains WD40 repeats.


ensembl_gene_id: YOR213C
symbol: SAS5
gene_biotype: protein_coding
description:
  Something about silencing protein 5; Subunit of the SAS complex (Sas2p, Sas4p, Sas5p); acetylates free histones and nucleosomes and regulates transcriptional silencing; stimulates Sas2p HAT activity.


ensembl_gene_id: YOR214C
symbol: SPR2
gene_biotype: protein_coding
description:
  Putative spore wall protein; expression increases during sporulation; not an essential gene; YOR214C has a paralog, SPO19, that arose from the whole genome duplication.


ensembl_gene_id: YOR215C
symbol: AIM41
gene_biotype: protein_coding
description:
  Altered inheritance of mitochondria protein 41, mitochondrial; Protein of unknown function; the authentic protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss.


ensembl_gene_id: YOR216C
symbol: RUD3
gene_biotype: protein_coding
description:
  GRIP domain-containing protein RUD3; Golgi matrix protein; involved in the structural organization of the cis-Golgi; interacts genetically with COG3 and USO1.


ensembl_gene_id: YOR217W
symbol: RFC1
gene_biotype: protein_coding
description:
  Subunit of heteropentameric Replication factor C (RF-C); RF-C is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon; Belongs to the activator 1 large subunit family.


ensembl_gene_id: YOR218C
symbol: YOR218C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YOR218C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene RFC1/YOR217W.


ensembl_gene_id: YOR219C
symbol: STE13
gene_biotype: protein_coding
description:
  Dipeptidyl aminopeptidase; Golgi integral membrane protein that cleaves on the carboxyl side of repeating -X-Ala- sequences, required for maturation of alpha factor, transcription is induced by a-factor.


ensembl_gene_id: YOR220W
symbol: RCN2
gene_biotype: protein_coding
description:
  Regulator of calcineurin 2; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; phosphorylated in response to alpha factor; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YOR221C
symbol: MCT1
gene_biotype: protein_coding
description:
  Malonyl CoA-acyl carrier protein transacylase, mitochondrial; Predicted malonyl-CoA:ACP transferase; putative component of a type-II mitochondrial fatty acid synthase that produces intermediates for phospholipid remodeling.


ensembl_gene_id: YOR222W
symbol: ODC2
gene_biotype: protein_coding
description:
  Mitochondrial inner membrane transporter; 2-oxodicarboxylate transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for use in lysine and glutamate biosynthesis and in lysine catabolism; ODC2 has a paralog, ODC1, that arose from the whole genome duplication; Belongs to the mitochondrial carrier (TC 2.A.29) family.


ensembl_gene_id: YOR223W
symbol: DSC3
gene_biotype: protein_coding
description:
  Subunit of the DSC ubiquitin ligase complex; protein of unknown function that localizes to the ER and vacuole lumen; overexpression affects endocytic protein trafficking; ortholog of fission yeast dsc3.


ensembl_gene_id: YOR225W
symbol: YOR225W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YOR225W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YOR226C
symbol: ISU2
gene_biotype: protein_coding
description:
  Mitochondrial protein required for iron-sulfur protein synthesis; performs scaffolding function during Fe/S cluster assembly; involved in Fe-S cluster assembly for both mitochondrial and cytosolic proteins; protein abundance increases under DNA replication stress; ISU2 has a paralog, ISU1, that arose from the whole genome duplication; isu1 isu2 double mutant is inviable; human homolog ISCU implicated in mitochondrial myopathy, can complement isu1 isu2 double mutant.


ensembl_gene_id: YOR227W
symbol: HER1
gene_biotype: protein_coding
description:
  HMG2-induced ER-remodeling protein 1; Protein of unknown function; required for proliferation or remodeling of the ER that is caused by overexpression of Hmg2p; may interact with ribosomes, based on co-purification experiments; HER1 has a paralog, GIP3, that arose from the whole genome duplication.


ensembl_gene_id: YOR228C
symbol: MCP1
gene_biotype: protein_coding
description:
  MDM10-complementing protein 1; Mitochondrial protein of unknown function involved in lipid homeostasis; integral membrane protein that localizes to the mitochondrial outer membrane; involved in mitochondrial morphology; interacts genetically with MDM10, and other members of the ERMES complex; contains five predicted transmembrane domains.


ensembl_gene_id: YOR229W
symbol: WTM2
gene_biotype: protein_coding
description:
  Transcriptional modulator; involved in regulation of meiosis, silencing, and expression of RNR genes; involved in response to replication stress; contains WD repeats; relocalizes to the cytosol in response to hypoxia; WTM2 has a paralog, UME1, that arose from the whole genome duplication.


ensembl_gene_id: YOR230W
symbol: WTM1
gene_biotype: protein_coding
description:
  Transcriptional modulator; involved in regulation of meiosis, silencing, and expression of RNR genes; required for nuclear localization of the ribonucleotide reductase small subunit Rnr2p and Rnr4p; contains WD repeats.


ensembl_gene_id: YOR231C-A
symbol: YOR231C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YOR231C-A; Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching.


ensembl_gene_id: YOR231W
symbol: MKK1
gene_biotype: protein_coding
description:
  MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication.


ensembl_gene_id: YOR232W
symbol: MGE1
gene_biotype: protein_coding
description:
  GrpE protein homolog, mitochondrial; Mitochondrial matrix cochaperone; nucleotide release factor for Ssc1p in protein translocation and folding; also acts as cochaperone for Ssq1p in folding of Fe-S cluster proteins; acts as oxidative sensor to regulate mitochondrial Ssc1p; in presence of oxidative stress, dimeric Mge1p becomes a monomer and unable to regulate Ssc1p function; homolog of E. coli GrpE and human Mge1 (GRPEL1), which also responds to oxidative stress; Belongs to the GrpE family.


ensembl_gene_id: YOR233W
symbol: KIN4
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase KIN4; Serine/threonine protein kinase; inhibits the mitotic exit network (MEN) when the spindle position checkpoint is activated; localized asymmetrically to mother cell cortex, spindle pole body and bud neck; KIN4 has a paralog, FRK1, that arose from the whole genome duplication.


ensembl_gene_id: YOR234C
symbol: RPL33B
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L33B; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33B has a paralog, RPL33A, that arose from the whole genome duplication.


ensembl_gene_id: YOR235W
symbol: IRC13
gene_biotype: protein_coding
description:
  Increased recombination centers protein 13; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; null mutant displays increased levels of spontaneous Rad52 foci.


ensembl_gene_id: YOR236W
symbol: DFR1
gene_biotype: protein_coding
description:
  Dihydrofolate reductase involved in tetrahydrofolate biosynthesis; required for respiratory metabolism; mutation is functionally complemented by human DHFR.


ensembl_gene_id: YOR237W
symbol: HES1
gene_biotype: protein_coding
description:
  Protein implicated in the regulation of ergosterol biosynthesis; one of a seven member gene family with a common essential function and non-essential unique functions; similar to human oxysterol binding protein (OSBP); SWAT-GFP and mCherry fusion proteins localize to the bud neck and vacuolar membrane; HES1 has a paralog, KES1, that arose from the whole genome duplication.


ensembl_gene_id: YOR238W
symbol: YOR238W
gene_biotype: protein_coding
description:
  Uncharacterized protein YOR238W; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm.


ensembl_gene_id: YOR239W
symbol: ABP140
gene_biotype: protein_coding
description:
  tRNA(Thr) (cytosine(32)-N(3))-methyltransferase; AdoMet-dependent tRNA methyltransferase and actin binding protein; C-terminal domain is responsible for 3-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA-Thr and tRNA-Ser and contains an S-adenosylmethionine (AdoMet) binding motif; N-terminal actin binding sequence interacts with actin filaments and localizes to actin patches and cables; N- and C-terminal domains are encoded in separate ORFs that are translated into one protein via a +1 frameshift.


ensembl_gene_id: YOR241W
symbol: MET7
gene_biotype: protein_coding
description:
  Folylpolyglutamate synthetase; catalyzes extension of the glutamate chains of the folate coenzymes, required for methionine synthesis and for maintenance of mitochondrial DNA; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YOR242C
symbol: SSP2
gene_biotype: protein_coding
description:
  Sporulation-specific protein 2; Sporulation specific protein that localizes to the spore wall; required for sporulation at a point after meiosis II and during spore wall formation; expression controlled by a tightly regulated middle-meiotic promoter that is activated by Ndt80p; translation of SSP2 mRNA is delayed, such that the mRNA is present as nuclear divisions are taking place but is not engaged by ribosomes until relatively late in meiotic development.


ensembl_gene_id: YOR243C
symbol: PUS7
gene_biotype: protein_coding
description:
  Pseudouridine synthase; catalyzes pseudouridylation at positions 35 and 56 in U2 snRNA, position 50 in 5S rRNA, position 13 in cytoplasmic tRNAs, and position 35 in pre-tRNA(Tyr); also pseudouridylates some mRNAs; relocates from nucleus to cytoplasm during heat shock and differentially modifies some mRNAs during heat shock; conserved in archaea, vertebrates, and some bacteria; Belongs to the pseudouridine synthase TruD family.


ensembl_gene_id: YOR244W
symbol: ESA1
gene_biotype: protein_coding
description:
  Catalytic subunit of the histone acetyltransferase complex (NuA4); acetylates four conserved internal lysines of histone H4 N-terminal tail and can acetylate histone H2A; master regulator of cellular acetylation balance; required for cell cycle progression and transcriptional silencing at the rDNA locus and regulation of autophagy; human ortholog TIP60/KAT5 is implicated in cancer and other diseases, functionally complements lethality of the esa1 null mutation.


ensembl_gene_id: YOR245C
symbol: DGA1
gene_biotype: protein_coding
description:
  Diacylglycerol O-acyltransferase 1; Diacylglycerol acyltransferase; catalyzes the terminal step of triacylglycerol (TAG) formation, acylates diacylglycerol using acyl-CoA as an acyl donor; Lro1p and Dga1p can O-acylate ceramides; localized to lipid particles.


ensembl_gene_id: YOR246C
symbol: ENV9
gene_biotype: protein_coding
description:
  Probable oxidoreductase ENV9; Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts.


ensembl_gene_id: YOR247W
symbol: SRL1
gene_biotype: protein_coding
description:
  Cell wall protein SRL1; Mannoprotein that exhibits a tight association with the cell wall; required for cell wall stability in the absence of GPI-anchored mannoproteins; has a high serine-threonine content; expression is induced in cell wall mutants; SRL1 has a paralog, SVS1, that arose from the whole genome duplication.


ensembl_gene_id: YOR248W
symbol: YOR248W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YOR248W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YOR249C
symbol: APC5
gene_biotype: protein_coding
description:
  Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; relative distribution to nuclear foci decreases upon DNA replication stress; Belongs to the APC5 family.


ensembl_gene_id: YOR250C
symbol: CLP1
gene_biotype: protein_coding
description:
  Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; involved in both the endonucleolyitc cleavage and polyadenylation steps of mRNA 3'-end maturation and in gene looping which affects reinitiation of transcription.


ensembl_gene_id: YOR251C
symbol: TUM1
gene_biotype: protein_coding
description:
  Thiosulfate sulfurtransferase TUM1; Rhodanese domain sulfur transferase; accepts persulfite from Nfs1p and transfers it to Uba4p in the pathway for 2-thiolation of the wobble uridine base of tRNAs; also stimulates sulfur transfer by Nfs1p; may be mitochondrially localized.


ensembl_gene_id: YOR252W
symbol: TMA16
gene_biotype: protein_coding
description:
  Translation machinery-associated protein 16; Protein of unknown function that associates with ribosomes; Belongs to the UPF0534 family.


ensembl_gene_id: YOR253W
symbol: NAT5
gene_biotype: protein_coding
description:
  N-alpha-acetyltransferase NAT5; Subunit of protein N-terminal acetyltransferase NatA; NatA is comprised of Nat1p, Ard1p, and Nat5p; N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing; Belongs to the acetyltransferase family.


ensembl_gene_id: YOR254C
symbol: SEC63
gene_biotype: protein_coding
description:
  Protein translocation protein SEC63; Essential subunit of Sec63 complex; with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER; other members are Sec62p, Sec66p, and Sec72p.


ensembl_gene_id: YOR255W
symbol: OSW1
gene_biotype: protein_coding
description:
  Outer spore wall protein 1; Protein involved in sporulation; required for the construction of the outer spore wall layers; required for proper localization of Spo14p.


ensembl_gene_id: YOR256C
symbol: TRE2
gene_biotype: protein_coding
description:
  Putative zinc metalloprotease TRE2; Transferrin receptor-like protein; functions with Tre1p to regulate ubiquitination and vacuolar degradation of the metal transporter Smf1p; inviability of null mutant in systematic studies is due to proximity to CDC31; TRE2 has a paralog, TRE1, that arose from the whole genome duplication; Belongs to the peptidase M28 family. M28B subfamily.


ensembl_gene_id: YOR257W
symbol: CDC31
gene_biotype: protein_coding
description:
  Cell division control protein 31; Calcium-binding component of the spindle pole body (SPB) half-bridge; required for SPB duplication in mitosis and meiosis II; homolog of mammalian centrin; binds multiubiquitinated proteins and is involved in proteasomal protein degradation.


ensembl_gene_id: YOR258W
symbol: HNT3
gene_biotype: protein_coding
description:
  Aprataxin-like protein; DNA 5' AMP hydrolase involved in DNA repair; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins; homolog of Aprataxin, a Hint related protein that is mutated in individuals with ataxia with oculomotor apraxia; relative distribution to nuclear foci decreases upon DNA replication stress.


ensembl_gene_id: YOR259C
symbol: RPT4
gene_biotype: protein_coding
description:
  26S proteasome subunit RPT4; ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in degradation of ubiquitinated substrates; contributes preferentially to ERAD; required for spindle pole body duplication; mainly nuclear localization.


ensembl_gene_id: YOR260W
symbol: GCD1
gene_biotype: protein_coding
description:
  Gamma subunit of the translation initiation factor eIF2B; the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression; Belongs to the eIF-2B gamma/epsilon subunits family.


ensembl_gene_id: YOR261C
symbol: RPN8
gene_biotype: protein_coding
description:
  Essential non-ATPase regulatory subunit of the 26S proteasome; has similarity to the human p40 proteasomal subunit and to another S. cerevisiae regulatory subunit, Rpn11p; Belongs to the peptidase M67A family.


ensembl_gene_id: YOR262W
symbol: GPN2
gene_biotype: protein_coding
description:
  GPN-loop GTPase 2; Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn3p; highly conserved across species and homologous to human gene GPN2/ATPBD1B; required for establishment of sister chromatid cohesion.


ensembl_gene_id: YOR263C
symbol: YOR263C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YOR263C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF DES3/YOR264W.


ensembl_gene_id: YOR264W
symbol: DSE3
gene_biotype: protein_coding
description:
  Protein DSE3; Daughter cell-specific protein, may help establish daughter fate; relocalizes from bud neck to cytoplasm upon DNA replication stress.


ensembl_gene_id: YOR265W
symbol: RBL2
gene_biotype: protein_coding
description:
  Tubulin-specific chaperone A; Protein involved in microtubule morphogenesis; required for protection from excess free beta-tubulin; proposed to be involved the folding of beta-tubulin; similar to mouse beta-tubulin cofactor A; protein abundance increases in response to DNA replication stress; Belongs to the TBCA family.


ensembl_gene_id: YOR266W
symbol: PNT1
gene_biotype: protein_coding
description:
  Pentamidine resistance factor, mitochondrial; Mitochondrial integral inner membrane protein; involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p; deletion mutant sensitive to the anti-Pneumocystis carinii drug pentamidine.


ensembl_gene_id: YOR267C
symbol: HRK1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase HRK1; Protein kinase; implicated in activation of the plasma membrane H(+)-ATPase Pma1p in response to glucose metabolism; plays a role in ion homeostasis; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YOR268C
symbol: YOR268C
gene_biotype: protein_coding
description:
  Uncharacterized protein YOR268C; Putative protein of unknown function; sporulation is abnormal in homozygous diploid; SWAT-GFP fusion protein localizes to the nucleus; YOR268C is not an essential gene.


ensembl_gene_id: YOR269W
symbol: PAC1
gene_biotype: protein_coding
description:
  Nuclear distribution protein PAC1; Involved in nuclear migration, part of the dynein/dynactin pathway; targets dynein to microtubule tips, which is necessary for sliding of microtubules along bud cortex; serves at interface between dynein's ATPase site and its microtubule binding stalk, causing individual dynein motors to remain attached to microtubules for long periods; synthetic lethal with bni1; homolog of human LIS1, mutations in which cause the severe brain disorder lissencephaly.


ensembl_gene_id: YOR270C
symbol: VPH1
gene_biotype: protein_coding
description:
  Subunit a of vacuolar-ATPase V0 domain; one of two isoforms (Vph1p and Stv1p); Vph1p is located in V-ATPase complexes of the vacuole while Stv1p is located in V-ATPase complexes of the Golgi and endosomes; relative distribution to the vacuolar membrane decreases upon DNA replication stress; human homolog ATP6V0A4 implicated in renal tubular acidosis, can complement yeast null mutant.


ensembl_gene_id: YOR271C
symbol: FSF1
gene_biotype: protein_coding
description:
  Sideroflexin FSF1; Putative protein; predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis.


ensembl_gene_id: YOR272W
symbol: YTM1
gene_biotype: protein_coding
description:
  Ribosome biogenesis protein YTM1; Constituent of 66S pre-ribosomal particles; forms a complex with Nop7p and Erb1p that is required for maturation of the large ribosomal subunit; has seven C-terminal WD repeats.


ensembl_gene_id: YOR273C
symbol: TPO4
gene_biotype: protein_coding
description:
  Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; localizes to the plasma membrane; Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.


ensembl_gene_id: YOR274W
symbol: MOD5
gene_biotype: protein_coding
description:
  Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase; required for biosynthesis of isopentenyladenosine in mitochondrial and cytoplasmic tRNAs; also has a role in tRNA gene-mediated silencing; gene encodes two isozymic forms; converts to a prion form, prion conversion contributes to azole antifungal resistance by upregulating ergosterol biosynthesis; homolog of human TRIT1, a mutation in which is associated with severe combined respiratory chain defects.


ensembl_gene_id: YOR275C
symbol: RIM20
gene_biotype: protein_coding
description:
  pH-response regulator protein palA/RIM20; Protein involved in proteolytic activation of Rim101p; part of response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation.


ensembl_gene_id: YOR276W
symbol: CAF20
gene_biotype: protein_coding
description:
  Cap-associated protein CAF20; Phosphoprotein of the mRNA cap-binding complex; involved in translational control; repressor of cap-dependent translation initiation; competes with eIF4G for binding to eIF4E; Belongs to the CAF20 family.


ensembl_gene_id: YOR277C
symbol: YOR277C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YOR277C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene CAF20.


ensembl_gene_id: YOR278W
symbol: HEM4
gene_biotype: protein_coding
description:
  Uroporphyrinogen III synthase; catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III, the fourth step in heme biosynthesis; deficiency in the human homolog can result in the disease congenital erythropoietic porphyria.


ensembl_gene_id: YOR279C
symbol: RFM1
gene_biotype: protein_coding
description:
  Repression factor of MSEs protein 1; Component of the Sum1p-Rfm1p-Hst1p complex; Rfm1p tethers the Hst1p histone deacetylase to the DNA-binding protein Sum1p; complex is involved in transcriptional repression of middle sporulation genes and in initiation of DNA replication.


ensembl_gene_id: YOR280C
symbol: FSH3
gene_biotype: protein_coding
description:
  Family of serine hydrolases 3; Putative serine hydrolase; likely target of Cyc8p-Tup1p-Rfx1p transcriptional regulation; sequence is similar to S. cerevisiae Fsh1p and Fsh2p and the human candidate tumor suppressor OVCA2; Belongs to the AB hydrolase 3 family.


ensembl_gene_id: YOR281C
symbol: PLP2
gene_biotype: protein_coding
description:
  Phosducin-like protein 2; Protein that interacts with the CCT complex to stimulate actin folding; has similarity to phosducins; null mutant lethality is complemented by mouse phosducin-like protein MgcPhLP; CCT is short for chaperonin containing TCP-1; essential gene.


ensembl_gene_id: YOR282W
symbol: YOR282W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YOR282W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C.


ensembl_gene_id: YOR283W
symbol: YOR283W
gene_biotype: protein_coding
description:
  Broad-specificity phosphatase YOR283W; Phosphatase with a broad substrate specificity; has some similarity to GPM1/YKL152C, a phosphoglycerate mutase; YOR283W is not an essential gene; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily.


ensembl_gene_id: YOR284W
symbol: HUA2
gene_biotype: protein_coding
description:
  Cytoplasmic protein of unknown function; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly.


ensembl_gene_id: YOR285W
symbol: RDL1
gene_biotype: protein_coding
description:
  Thiosulfate sulfurtransferase; contains a rhodanese-like domain; localized to the mitochondrial outer membrane; protein abundance increases in response to DNA replication stress; similar to the human TSTD gene.


ensembl_gene_id: YOR286W
symbol: RDL2
gene_biotype: protein_coding
description:
  Thiosulfate sulfurtransferase RDL2, mitochondrial; Protein with rhodanese activity; contains a rhodanese-like domain similar to Rdl1p, Uba4p, Tum1p, and Ych1p; overexpression causes a cell cycle delay; null mutant displays elevated frequency of mitochondrial genome loss.


ensembl_gene_id: YOR287C
symbol: RRP36
gene_biotype: protein_coding
description:
  rRNA biogenesis protein RRP36; Component of 90S preribosomes; involved in early cleavages of the 35S pre-rRNA and in production of the 40S ribosomal subunit; Belongs to the RRP36 family.


ensembl_gene_id: YOR288C
symbol: MPD1
gene_biotype: protein_coding
description:
  Protein disulfide-isomerase MPD1; Member of the protein disulfide isomerase (PDI) family; interacts with and inhibits the chaperone activity of Cne1p; MPD1 overexpression in a pdi1 null mutant suppresses defects in Pdi1p functions such as carboxypeptidase Y maturation.


ensembl_gene_id: YOR289W
symbol: YOR289W
gene_biotype: protein_coding
description:
  Uncharacterized protein YOR289W; Putative protein of unknown function; transcription induced by the unfolded protein response; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus.


ensembl_gene_id: YOR290C
symbol: SNF2
gene_biotype: protein_coding
description:
  Transcription regulatory protein SNF2; Catalytic subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p.


ensembl_gene_id: YOR291W
symbol: YPK9
gene_biotype: protein_coding
description:
  Vacuolar cation-transporting ATPase YPK9; Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.


ensembl_gene_id: YOR292C
symbol: YOR292C
gene_biotype: protein_coding
description:
  Vacuolar membrane protein YOR292C; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YOR292C is not an essential gene; Belongs to the peroxisomal membrane protein PXMP2/4 family.


ensembl_gene_id: YOR293C-A
symbol: YOR293C-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YOR293C-A; Putative protein of unknown function; identified by expression profiling and mass spectrometry.


ensembl_gene_id: YOR293W
symbol: RPS10A
gene_biotype: protein_coding
description:
  Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication; mutations in the human homolog associated with Diamond-Blackfan anemia.


ensembl_gene_id: YOR294W
symbol: RRS1
gene_biotype: protein_coding
description:
  Regulator of ribosome biosynthesis; Essential protein that binds ribosomal protein L11; required for nuclear export of the 60S pre-ribosomal subunit during ribosome biogenesis; localizes to the nucleolus and in foci along nuclear periphery; cooperates with Ebp2p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering; mouse homolog shows altered expression in Huntington's disease model mice; Belongs to the RRS1 family.


ensembl_gene_id: YOR295W
symbol: UAF30
gene_biotype: protein_coding
description:
  Subunit of UAF (upstream activation factor) complex; UAF is an RNA polymerase I specific transcription stimulatory factor composed of Uaf30p, Rrn5p, Rrn9p, Rrn10p, histones H3 and H4; targeting factor for the UAF that facilitates activation of many rDNA genes; deletion decreases cellular growth rate; UAF30 has a paralog, TRI1, that arose from the whole genome duplication.


ensembl_gene_id: YOR296W
symbol: YOR296W
gene_biotype: protein_coding
description:
  Uncharacterized protein YOR296W; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; expressed during copper starvation; YOR296W is not an essential gene.


ensembl_gene_id: YOR297C
symbol: TIM18
gene_biotype: protein_coding
description:
  Mitochondrial import inner membrane translocase subunit TIM18; Component of the mitochondrial TIM22 complex; involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex; Belongs to the CybS family.


ensembl_gene_id: YOR298C-A
symbol: MBF1
gene_biotype: protein_coding
description:
  Multiprotein-bridging factor 1; Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress; Belongs to the MBF1 family.


ensembl_gene_id: YOR298W
symbol: MUM3
gene_biotype: protein_coding
description:
  Protein of unknown function involved in outer spore wall organization; has similarity to the tafazzins superfamily of acyltransferases.


ensembl_gene_id: YOR299W
symbol: BUD7
gene_biotype: protein_coding
description:
  Bud site selection protein 7; Member of the ChAPs family (Chs5p-Arf1p-binding proteins); members include Bch1p, Bch2p, Bud7p, and Chs6p; ChAPs family proteins form the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; BUD7 has a paralog, BCH1, that arose from the whole genome duplication.


ensembl_gene_id: YOR300W
symbol: YOR300W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YOR300W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7.


ensembl_gene_id: YOR301W
symbol: RAX1
gene_biotype: protein_coding
description:
  Protein involved in bud site selection during bipolar budding; localization requires Rax2p; has similarity to members of the insulin-related peptide superfamily.


ensembl_gene_id: YOR303W
symbol: CPA1
gene_biotype: protein_coding
description:
  Carbamoyl-phosphate synthase arginine-specific small chain; Small subunit of carbamoyl phosphate synthetase; carbamoyl phosphate synthetase catalyzes a step in the synthesis of citrulline, an arginine precursor; translationally regulated by an attenuator peptide encoded by YOR302W within the CPA1 mRNA 5'-leader; Belongs to the CarA family.


ensembl_gene_id: YOR304C-A
symbol: BIL1
gene_biotype: protein_coding
description:
  Uncharacterized protein YOR304C-A; Protein that binds Bud6p and has a role in actin cable assembly; involved in the Bnr1p-dependent pathway of cable assembly; localizes to bud tip and bud neck.


ensembl_gene_id: YOR304W
symbol: ISW2
gene_biotype: protein_coding
description:
  ISWI chromatin-remodeling complex ATPase ISW2; ATP-dependent DNA translocase involved in chromatin remodeling; ATPase component that, with Itc1p, forms a complex required for repression of a-specific genes, INO1, and early meiotic genes during mitotic growth; the Isw2 complex exhibits basal levels of chromatin binding throughout the genome as well as target-specific chromatin interactions; targeted by Ume6p- and Sua7p-dependent DNA looping to many loci genome-wide.


ensembl_gene_id: YOR305W
symbol: RRG7
gene_biotype: protein_coding
description:
  Required for respiratory growth protein 7, mitochondrial; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YOR305W is not an essential gene.


ensembl_gene_id: YOR306C
symbol: MCH5
gene_biotype: protein_coding
description:
  Plasma membrane riboflavin transporter; facilitates the uptake of vitamin B2; required for FAD-dependent processes; sequence similarity to mammalian monocarboxylate permeases, however mutants are not deficient in monocarboxylate transport.


ensembl_gene_id: YOR308C
symbol: SNU66
gene_biotype: protein_coding
description:
  66 kDa U4/U6.U5 small nuclear ribonucleoprotein component; Component of the U4/U6.U5 snRNP complex; involved in pre-mRNA splicing via spliceosome; also required for pre-5S rRNA processing and may act in concert with Rnh70p; has homology to human SART-1.


ensembl_gene_id: YOR309C
symbol: YOR309C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YOR309C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP58.


ensembl_gene_id: YOR310C
symbol: NOP58
gene_biotype: protein_coding
description:
  Nucleolar protein 58; Protein involved in producing mature rRNAs and snoRNAs; involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNA.


ensembl_gene_id: YOR311C
symbol: DGK1
gene_biotype: protein_coding
description:
  Diacylglycerol kinase; localized to the endoplasmic reticulum (ER); overproduction induces enlargement of ER-like membrane structures and suppresses a temperature-sensitive sly1 mutation; contains a CTP transferase domain; Belongs to the DGK1 family.


ensembl_gene_id: YOR312C
symbol: RPL20B
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L20B; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20B has a paralog, RPL20A, that arose from the whole genome duplication.


ensembl_gene_id: YOR313C
symbol: SPS4
gene_biotype: protein_coding
description:
  Sporulation-specific protein 4; Protein whose expression is induced during sporulation; not required for sporulation; heterologous expression in E. coli induces the SOS response that senses DNA damage.


ensembl_gene_id: YOR314W
symbol: YOR314W
gene_biotype: protein_coding
description:
  Uncharacterized protein YOR314W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YOR314W-A
symbol: YOR314W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YOR314W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YOR315W
symbol: SFG1
gene_biotype: protein_coding
description:
  Nuclear protein putative transcription factor; required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate.


ensembl_gene_id: YOR316C
symbol: COT1
gene_biotype: protein_coding
description:
  Cobalt uptake protein COT1; Vacuolar transporter that mediates zinc transport into the vacuole; overexpression confers resistance to cobalt and rhodium; protein abundance increases in response to DNA replication stress; COT1 has a paralog, ZRC1, that arose from the whole genome duplication; Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.


ensembl_gene_id: YOR316C-A
symbol: YOR316C-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YOR316C-A; Putative protein of unknown function; identified by fungal homology and RT-PCR.


ensembl_gene_id: YOR317W
symbol: FAA1
gene_biotype: protein_coding
description:
  Long-chain-fatty-acid--CoA ligase 1; Long chain fatty acyl-CoA synthetase; activates fatty acids with a preference for C12:0-C16:0 chain lengths; role in the competitive import of long-chain fatty acids and sphingoid long-chain bases; accounts for most acyl-CoA synthetase activity; localizes to lipid particles and the plasma membrane; role in sphingolipid-to-glycerolipid metabolism; forms ER foci upon replication stress; faa1 faa4 double null complemented by any of human ACSBG1, ACSL1, 3, 4, 5, 6, SLC27A2, or 4.


ensembl_gene_id: YOR318C
symbol: YOR318C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YOR318C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; transcript is predicted to be spliced but there is no evidence that it is spliced in vivo.


ensembl_gene_id: YOR319W
symbol: HSH49
gene_biotype: protein_coding
description:
  Protein HSH49; U2-snRNP associated splicing factor; similar to the mammalian splicing factor SAP49; proposed to function as a U2-snRNP assembly factor along with Hsh155p and binding partner Cus1p; contains two RNA recognition motifs (RRM).


ensembl_gene_id: YOR320C
symbol: GNT1
gene_biotype: protein_coding
description:
  Glucose N-acetyltransferase 1; N-acetylglucosaminyltransferase; capable of modification of N-linked glycans in the Golgi apparatus; Belongs to the GNT1 family.


ensembl_gene_id: YOR321W
symbol: PMT3
gene_biotype: protein_coding
description:
  Dolichyl-phosphate-mannose--protein mannosyltransferase 3; Protein O-mannosyltransferase; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt5p, can instead interact with Pmt1p in some conditions; antifungal drug target; PMT3 has a paralog, PMT2, that arose from the whole genome duplication; Belongs to the glycosyltransferase 39 family.


ensembl_gene_id: YOR322C
symbol: LDB19
gene_biotype: protein_coding
description:
  Protein LDB19; Alpha-arrestin involved in ubiquitin-dependent endocytosis; regulates endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its targets; involved in the basal internalization and turnover of alpha-factor receptor Ste2p; recruits ubiquitin ligase Rsp5p to Ste2p via its 2 PPXY motifs; inhibited by Npr1p-mediated phosphorylation, which affects translocation between the cytosol and the plasma membrane.


ensembl_gene_id: YOR324C
symbol: FRT1
gene_biotype: protein_coding
description:
  Protein HPH1; Tail-anchored ER membrane protein of unknown function; substrate of the phosphatase calcineurin; interacts with homolog Frt2p; promotes cell growth in stress conditions, possibly via a role in posttranslational translocation; FRT1 has a paralog, FRT2, that arose from the whole genome duplication.


ensembl_gene_id: YOR325W
symbol: YOR325W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YOR325W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF FRT1.


ensembl_gene_id: YOR326W
symbol: MYO2
gene_biotype: protein_coding
description:
  Myosin-2; Type V myosin motor involved in actin-based transport of cargos; required for the polarized delivery of secretory vesicles, the vacuole, late Golgi elements, peroxisomes, and the mitotic spindle; MYO2 has a paralog, MYO4, that arose from the whole genome duplication; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.


ensembl_gene_id: YOR327C
symbol: SNC2
gene_biotype: protein_coding
description:
  Synaptobrevin homolog 2; Vesicle membrane receptor protein (v-SNARE); involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; Snc2p levels regulated by Vps45p; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins; SNC2 has a paralog, SNC1, that arose from the whole genome duplication.


ensembl_gene_id: YOR328W
symbol: PDR10
gene_biotype: protein_coding
description:
  ATP-dependent permease PDR10; ATP-binding cassette (ABC) transporter; multidrug transporter involved in the pleiotropic drug resistance network; regulated by Pdr1p and Pdr3p; Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.


ensembl_gene_id: YOR329C
symbol: SCD5
gene_biotype: protein_coding
description:
  Protein required for normal actin organization and endocytosis; targeting subunit for protein phosphatase type 1; undergoes Crm1p-dependent nuclear-cytoplasmic shuttling; multicopy suppressor of clathrin deficiency.


ensembl_gene_id: YOR329W-A
symbol: YOR329W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YOR329W-A; Dubious open reading frame unlikely to encode a functional protein; identified by fungal homology and RT-PCR.


ensembl_gene_id: YOR330C
symbol: MIP1
gene_biotype: protein_coding
description:
  Mitochondrial DNA polymerase gamma; single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoan complex of catalytic and accessory subunits; polymorphic in yeast, petites occur more frequently in some lab strains; human ortholog POLG complements yeast mip1 mutant; mutations in human POLG associated with Alpers-Huttenlocher syndrome (AHS), progressive external ophthalmoplegia (PEO), parkinsonism, other mitochondrial diseases.


ensembl_gene_id: YOR331C
symbol: YOR331C
gene_biotype: protein_coding
description:
  Putative uncharacterized membrane protein YOR331C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene VMA4/YOR332W.


ensembl_gene_id: YOR332W
symbol: VMA4
gene_biotype: protein_coding
description:
  Subunit E of the V1 domain of the vacuolar H+-ATPase (V-ATPase); V-ATPase is an electrogenic proton pump found throughout the endomembrane system; V1 domain has eight subunits; required for the V1 domain to assemble onto the vacuolar membrane; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YOR333C
symbol: YOR333C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YOR333C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of MRS2 gene required for respiratory growth.


ensembl_gene_id: YOR334W
symbol: MRS2
gene_biotype: protein_coding
description:
  Magnesium transporter MRS2, mitochondrial; Mitochondrial inner membrane Mg(2+) channel; required for maintenance of intramitochondrial Mg(2+) concentrations at the correct level to support splicing of group II introns; similar to bacterial CorA.


ensembl_gene_id: YOR335C
symbol: ALA1
gene_biotype: protein_coding
description:
  Alanine--tRNA ligase, mitochondrial; Cytoplasmic and mitochondrial alanyl-tRNA synthetase; required for protein synthesis; point mutation (cdc64-1 allele) causes cell cycle arrest at G1; lethality of null mutation is functionally complemented by human homolog AARS; mutations in human homolog AARS are associated with autoimmune disease polymyositis/dermatomyositis; Belongs to the class-II aminoacyl-tRNA synthetase family.


ensembl_gene_id: YOR335W-A
symbol: YOR335W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YOR335W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ALA1/YOR335C.


ensembl_gene_id: YOR336W
symbol: KRE5
gene_biotype: protein_coding
description:
  Killer toxin-resistance protein 5; Protein required for beta-1,6 glucan biosynthesis; mutations result in aberrant morphology and severe growth defects.


ensembl_gene_id: YOR337W
symbol: TEA1
gene_biotype: protein_coding
description:
  Ty1 enhancer activator involved in Ty enhancer-mediated transcription; required for full levels of Ty enhancer-mediated transcription; C6 zinc cluster DNA-binding protein.


ensembl_gene_id: YOR338W
symbol: YOR338W
gene_biotype: protein_coding
description:
  Putative protein of unknown function; YOR338W transcription is regulated by Azf1p and its transcript is a specific target of the G protein effector Scp160p; identified as being required for sporulation in a high-throughput mutant screen; YOR338W has a paralog, FUN19, that arose from the whole genome duplication.


ensembl_gene_id: YOR339C
symbol: UBC11
gene_biotype: protein_coding
description:
  Ubiquitin-conjugating enzyme; most similar in sequence to Xenopus ubiquitin-conjugating enzyme E2-C, but not a true functional homolog of this E2; unlike E2-C, not required for the degradation of mitotic cyclin Clb2.


ensembl_gene_id: YOR342C
symbol: YOR342C
gene_biotype: protein_coding
description:
  Uncharacterized protein YOR342C; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; relocalizes from nucleus to cytoplasm upon DNA replication stress; YOR342C has a paralog, YAL037W, that arose from the whole genome duplication.


ensembl_gene_id: YOR343C
symbol: YOR343C
gene_biotype: protein_coding
description:
  Uncharacterized protein YOR343C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YOR344C
symbol: TYE7
gene_biotype: protein_coding
description:
  Serine-rich protein that contains a bHLH DNA binding motif; binds E-boxes of glycolytic genes and contributes to their activation; may function as a transcriptional activator in Ty1-mediated gene expression; bHLH stands for basic-helix-loop-helix.


ensembl_gene_id: YOR345C
symbol: YOR345C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YOR345C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene REV1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2.


ensembl_gene_id: YOR346W
symbol: REV1
gene_biotype: protein_coding
description:
  DNA repair protein REV1; Deoxycytidyl transferase; involved in repair of abasic sites and adducted guanines in damaged DNA by translesion synthesis (TLS); forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; relocalizes from nucleus to cytoplasm upon DNA replication stress.


ensembl_gene_id: YOR347C
symbol: PYK2
gene_biotype: protein_coding
description:
  Pyruvate kinase; appears to be modulated by phosphorylation; transcription repressed by glucose, and Pyk2p may be active under low glycolytic flux; PYK2 has a paralog, CDC19, that arose from the whole genome duplication.


ensembl_gene_id: YOR348C
symbol: PUT4
gene_biotype: protein_coding
description:
  Proline permease; required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells.


ensembl_gene_id: YOR349W
symbol: CIN1
gene_biotype: protein_coding
description:
  Chromosome instability protein 1; Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl.


ensembl_gene_id: YOR351C
symbol: MEK1
gene_biotype: protein_coding
description:
  Meiosis-specific serine/threonine protein kinase; functions in meiotic checkpoint, promotes recombination between homologous chromosomes by suppressing double strand break repair between sister chromatids; stabilizes Hop1-Thr318 phosphorylation to promote interhomolog recombination and checkpoint responses during meiosis.


ensembl_gene_id: YOR352W
symbol: TFB6
gene_biotype: protein_coding
description:
  Uncharacterized protein YOR352W; Subunit of TFIIH complex; facilities dissociation of the Ssl2p helices from TFIIH; expression levels regulated by Arg5,6p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus.


ensembl_gene_id: YOR353C
symbol: SOG2
gene_biotype: protein_coding
description:
  Leucine-rich repeat-containing protein SOG2; Key component of the RAM signaling network; required for proper cell morphogenesis and cell separation after mitosis.


ensembl_gene_id: YOR354C
symbol: MSC6
gene_biotype: protein_coding
description:
  Multicopy suppressor of HER2 involved in mitochondrial translation; mutant is defective in directing meiotic recombination events to homologous chromatids.


ensembl_gene_id: YOR355W
symbol: GDS1
gene_biotype: protein_coding
description:
  Protein of unknown function; required for growth on glycerol as a carbon source; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies.


ensembl_gene_id: YOR356W
symbol: CIR2
gene_biotype: protein_coding
description:
  Probable electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial; Putative ortholog of human ETF-dH; found in a large supramolecular complex with other mitochondrial dehydrogenases; may have a role in oxidative stress response; ETF-dH is also known as electron transfer flavoprotein dehydrogenase.


ensembl_gene_id: YOR357C
symbol: SNX3
gene_biotype: protein_coding
description:
  Sorting nexin for late-Golgi enzymes; required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p.


ensembl_gene_id: YOR358W
symbol: HAP5
gene_biotype: protein_coding
description:
  Transcriptional activator HAP5; Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex; complex is heme-activated and glucose repressed; complex is a transcriptional activator and global regulator of respiratory gene expression; required for assembly and DNA binding activity of the complex.


ensembl_gene_id: YOR359W
symbol: VTS1
gene_biotype: protein_coding
description:
  Protein VTS1; Flap-structured DNA-binding and RNA-binding protein; stimulates deadenylation-dependent mRNA degradation mediated by the CCR4-NOT deadenylase complex; member of the Smaug (Smg) family of post-transcriptional regulators which bind RNA through a conserved sterile alpha motif (SAM) domain that interacts with Smg recognition element (SREs) containing transcripts; stimulates Dna2p endonuclease activity.


ensembl_gene_id: YOR360C
symbol: PDE2
gene_biotype: protein_coding
description:
  3',5'-cyclic-nucleotide phosphodiesterase 2; High-affinity cyclic AMP phosphodiesterase; component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon.


ensembl_gene_id: YOR361C
symbol: PRT1
gene_biotype: protein_coding
description:
  eIF3b subunit of the eukaryotic translation initiation factor 3 (eIF3); subunit of the core complex of eIF3; essential for translation; part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomes; eIF3 is also involved in programmed stop codon readthrough.


ensembl_gene_id: YOR362C
symbol: PRE10
gene_biotype: protein_coding
description:
  Alpha 7 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YOR363C
symbol: PIP2
gene_biotype: protein_coding
description:
  Peroxisome proliferation transcriptional regulator; Autoregulatory, oleate-activated transcription factor; subunit of a heterodimeric complex with Oaf1p, which binds to oleate-response elements (ORE) in the promoter of genes involved in beta-oxidation of fatty acids, peroxisome organization and biogenesis, activating transcription in the presence of oleate; PIP2 has a paralog, OAF1, that arose from the whole genome duplication.


ensembl_gene_id: YOR364W
symbol: YOR364W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YOR364W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR365C.


ensembl_gene_id: YOR365C
symbol: YOR365C
gene_biotype: protein_coding
description:
  Putative protein of unknown function; not an essential protein; YOR365C has a paralog, FLC2, that arose from the whole genome duplication.


ensembl_gene_id: YOR366W
symbol: YOR366W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YOR366W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR365C.


ensembl_gene_id: YOR367W
symbol: SCP1
gene_biotype: protein_coding
description:
  Transgelin; Component of yeast cortical actin cytoskeleton; binds and cross links actin filaments; originally identified by its homology to calponin (contains a calponin-like repeat) but the Scp1p domain structure is more similar to transgelin.


ensembl_gene_id: YOR368W
symbol: RAD17
gene_biotype: protein_coding
description:
  Checkpoint protein; involved in the activation of the DNA damage and meiotic pachytene checkpoints; with Mec3p and Ddc1p, forms a clamp that is loaded onto partial duplex DNA; homolog of human and S. pombe Rad1 and U. maydis Rec1 proteins.


ensembl_gene_id: YOR369C
symbol: RPS12
gene_biotype: protein_coding
description:
  Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S12, no bacterial homolog.


ensembl_gene_id: YOR370C
symbol: MRS6
gene_biotype: protein_coding
description:
  Rab proteins geranylgeranyltransferase component A; Rab escort protein; forms a complex with the Ras-like small GTPase Ypt1p that is required for the prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p); sequence similarity to mammalian choroideraemia gene; relative distribution to the nucleus increases upon DNA replication stress.


ensembl_gene_id: YOR371C
symbol: GPB1
gene_biotype: protein_coding
description:
  Guanine nucleotide-binding protein subunit beta 1; Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; promotes ubiquitin-dependent proteolysis of Ira2p; regulated by G-alpha protein Gpa2p; GPB1 has a paralog, GPB2, that arose from the whole genome duplication.


ensembl_gene_id: YOR372C
symbol: NDD1
gene_biotype: protein_coding
description:
  Nuclear division defective protein 1; Transcriptional activator essential for nuclear division; localized to the nucleus; essential component of the mechanism that activates the expression of a set of late-S-phase-specific genes; turnover is tightly regulated during cell cycle and in response to DNA damage.


ensembl_gene_id: YOR373W
symbol: NUD1
gene_biotype: protein_coding
description:
  Protein NUD1; Component of the spindle pole body outer plaque; acts through the mitotic exit network to specify asymmetric spindle pole body inheritance.


ensembl_gene_id: YOR374W
symbol: ALD4
gene_biotype: protein_coding
description:
  Mitochondrial aldehyde dehydrogenase; required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed; can substitute for cytosolic NADP-dependent aldehyde dehydrogenase when directed to the cytosol; human homolog ALDH2 can complement yeast ald4 mutant.


ensembl_gene_id: YOR375C
symbol: GDH1
gene_biotype: protein_coding
description:
  NADP(+)-dependent glutamate dehydrogenase; synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh3p; expression regulated by nitrogen and carbon sources; GDH1 has a paralog, GDH3, that arose from the whole genome duplication.


ensembl_gene_id: YOR376W
symbol: YOR376W
gene_biotype: protein_coding
description:
  Uncharacterized membrane protein YOR376W; Putative protein of unknown function; conserved among S. cerevisiae strains; YOR376W is not an essential gene.


ensembl_gene_id: YOR376W-A
symbol: YOR376W-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YOR376W-A; Putative protein of unknown function; identified by fungal homology and RT-PCR.


ensembl_gene_id: YOR377W
symbol: ATF1
gene_biotype: protein_coding
description:
  Alcohol O-acetyltransferase 1; Alcohol acetyltransferase; responsible for the major part of volatile acetate ester production during fermentation; main enzyme involved in terpenyl acetate synthesis; potential roles in lipid and sterol metabolism.


ensembl_gene_id: YOR378W
symbol: AMF1
gene_biotype: protein_coding
description:
  Low affinity NH4+ transporter; member of the DHA2 family of drug:H+ anti porters; putative paralog of ATR1; but not required for boron tolerance; non-essential gene; Belongs to the major facilitator superfamily.


ensembl_gene_id: YOR379C
symbol: YOR379C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YOR379C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR378W.


ensembl_gene_id: YOR380W
symbol: RDR1
gene_biotype: protein_coding
description:
  Protein RDR1; Transcriptional repressor involved in regulating multidrug resistance; negatively regulates expression of the PDR5 gene; member of the Gal4p family of zinc cluster proteins.


ensembl_gene_id: YOR381W
symbol: FRE3
gene_biotype: protein_coding
description:
  Ferric reductase transmembrane component 3; Ferric reductase; reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels; Belongs to the ferric reductase (FRE) family.


ensembl_gene_id: YOR381W-A
symbol: YOR381W-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YOR381W-A; Putative protein of unknown function; identified by fungal homology and RT-PCR.


ensembl_gene_id: YOR382W
symbol: FIT2
gene_biotype: protein_coding
description:
  Facilitator of iron transport 2; Mannoprotein that is incorporated into the cell wall; incorporated via a glycosylphosphatidylinositol (GPI) anchor; involved in the retention of siderophore-iron in the cell wall.


ensembl_gene_id: YOR383C
symbol: FIT3
gene_biotype: protein_coding
description:
  Facilitator of iron transport 3; Mannoprotein that is incorporated into the cell wall; incorporated via a glycosylphosphatidylinositol (GPI) anchor; involved in the retention of siderophore-iron in the cell wall.


ensembl_gene_id: YOR384W
symbol: FRE5
gene_biotype: protein_coding
description:
  Ferric reductase transmembrane component 5; Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies.


ensembl_gene_id: YOR385W
symbol: YOR385W
gene_biotype: protein_coding
description:
  Uncharacterized protein YOR385W; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YOR385W is not an essential gene.


ensembl_gene_id: YOR386W
symbol: PHR1
gene_biotype: protein_coding
description:
  Deoxyribodipyrimidine photo-lyase, mitochondrial; DNA photolyase involved in photoreactivation; repairs pyrimidine dimers in the presence of visible light; induced by DNA damage; regulated by transcriptional repressor Rph1p.


ensembl_gene_id: YOR387C
symbol: YOR387C
gene_biotype: protein_coding
description:
  VEL1-related protein YOR387C; Putative protein of unknown function; regulated by the metal-responsive Aft1p transcription factor; highly inducible in zinc-depleted conditions; localizes to the soluble fraction; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively; YOR387C has a paralog, VEL1, that arose from a single-locus duplication.


ensembl_gene_id: YOR388C
symbol: FDH1
gene_biotype: protein_coding
description:
  NAD(+)-dependent formate dehydrogenase; may protect cells from exogenous formate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.


ensembl_gene_id: YOR389W
symbol: YOR389W
gene_biotype: protein_coding
description:
  Uncharacterized protein YOR389W; Putative protein of unknown function; expression regulated by copper levels.


ensembl_gene_id: YOR390W
symbol: FEX1
gene_biotype: protein_coding
description:
  Protein involved in fluoride export; nearly identical to FEX2, and deletion of both proteins results in a large increase in fluoride sensitivity compared with the single mutant; contains two FEX domains connected by a linker; part of a widespread family of conserved fluoride export proteins; Belongs to the fluoride exporter Fluc/FEX family.


ensembl_gene_id: YOR391C
symbol: HSP33
gene_biotype: protein_coding
description:
  Probable glutathione-independent glyoxalase HSP33; Possible chaperone and cysteine protease; required for transcriptional reprogramming during the diauxic shift and for survival in stationary phase; similar to E. coli Hsp31 and S. cerevisiae Hsp31p, Hsp32p, and Sno4p; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease and cancer; Belongs to the peptidase C56 family. HSP31-like subfamily.


ensembl_gene_id: YOR392W
symbol: YOR392W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YOR392W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; gene expression induced by heat.


ensembl_gene_id: YOR394C-A
symbol: YOR394C-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YOR394C-A; Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching.


ensembl_gene_id: YOR394W
symbol: PAU21
gene_biotype: protein_coding
description:
  Seripauperin-21; Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions; SWAT-GFP, seamless-GFP and mCherry fusion proteins localize to the cytosol; identical to Pau22p; encodes two proteins that are translated from 2 different start codons; Belongs to the SRP1/TIP1 family. Seripauperin subfamily.


ensembl_gene_id: YOR396W
symbol: YRF1-8
gene_biotype: protein_coding
description:
  One of several telomeric Y' element-encoded DNA helicases; known as Y'-Help1 (Y'-HELicase Protein 1).


ensembl_gene_id: YPL001W
symbol: HAT1
gene_biotype: protein_coding
description:
  Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex; uses the cofactor acetyl coenzyme A to acetylate free nuclear and cytoplasmic histone H4; involved in telomeric silencing and DNA double-strand break repair.


ensembl_gene_id: YPL002C
symbol: SNF8
gene_biotype: protein_coding
description:
  Vacuolar-sorting protein SNF8; Component of the ESCRT-II complex; ESCRT-II is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression.


ensembl_gene_id: YPL003W
symbol: ULA1
gene_biotype: protein_coding
description:
  NEDD8-activating enzyme E1 regulatory subunit; Protein that activates Rub1p (NEDD8) before neddylation; acts together with Uba3p; may play a role in protein degradation; Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.


ensembl_gene_id: YPL004C
symbol: LSP1
gene_biotype: protein_coding
description:
  Sphingolipid long chain base-responsive protein LSP1; Eisosome core component; eisosomes are large immobile patch structures at the cell cortex associated with endocytosis; phosphorylated on Thr233 upon Pkc1p hyperactivation in a Slt2p MAPK-dependent fashion; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; member of the BAR domain family.


ensembl_gene_id: YPL005W
symbol: AEP3
gene_biotype: protein_coding
description:
  ATPase expression protein 3; Peripheral mitochondrial inner membrane protein; may facilitate use of unformylated tRNA-Met in mitochondrial translation initiation; stabilizes the bicistronic AAP1-ATP6 mRNA.


ensembl_gene_id: YPL006W
symbol: NCR1
gene_biotype: protein_coding
description:
  NPC intracellular sterol transporter 1-related protein 1; Vacuolar membrane protein; transits through the biosynthetic vacuolar protein sorting pathway, involved in sphingolipid metabolism; cells lacking Ncr1p exhibit high levels of long chain bases (LCB), similar to the accumulation of high amounts of lipids observed in patients with Neimann-Pick C, a disease caused by loss-of-function mutations in NPC1, the functional ortholog of Ncr1p; Belongs to the patched family.


ensembl_gene_id: YPL007C
symbol: TFC8
gene_biotype: protein_coding
description:
  Subunit of RNA polymerase III transcription initiation factor complex; one of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; linker between TauB and TauA domains; human homolog is TFIIIC-90.


ensembl_gene_id: YPL008W
symbol: CHL1
gene_biotype: protein_coding
description:
  Probable DNA helicase; involved in sister-chromatid cohesion and genome integrity and interstrand cross-link repair; interacts with ECO1 and CTF18; mutants are defective in silencing, rDNA recombination, aging and the heat shock response; FANCJ-like helicase family member; mutations in the human homolog, DDX11/ChLR1, cause Warsaw breakage syndrome; Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.


ensembl_gene_id: YPL009C
symbol: RQC2
gene_biotype: protein_coding
description:
  Ribosome quality control complex subunit 2; Component of RQC, which mediates nascent chain degradation; RQC (ribosome quality control complex) is a ribosome-bound complex required for degradation of polypeptides arising from stalled translation; recruits alanine- and threonine-charged tRNA to the A site and directs the elongation of nascent chains independently of mRNA or 40S subunits; monitors translation stress and signals this to Hsf1p; Belongs to the NEMF family.


ensembl_gene_id: YPL010W
symbol: RET3
gene_biotype: protein_coding
description:
  Zeta subunit of the coatomer complex (COPI); COPI coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER.


ensembl_gene_id: YPL011C
symbol: TAF3
gene_biotype: protein_coding
description:
  TFIID subunit (47 kDa); involved in promoter binding and RNA polymerase II transcription initiation; Belongs to the TAF3 family.


ensembl_gene_id: YPL012W
symbol: RRP12
gene_biotype: protein_coding
description:
  Protein required for export of the ribosomal subunits; associates with the RNA components of the pre-ribosomes; has a role in nuclear import in association with Pse1p; also plays a role in the cell cycle and the DNA damage response; contains HEAT-repeats.


ensembl_gene_id: YPL014W
symbol: CIP1
gene_biotype: protein_coding
description:
  Uncharacterized protein YPL014W; Cyclin-dependent kinase inhibitor; interacts with and inhibits the Cdc28p/Cln2p, G1/S phase cyclin-dependent kinase complex but not S-phase, or M-phase complexes; overexpression blocks cells in G1 phase and stabilizes the Cdc28p inhibitor Sic1p, while disruption accelerates the G1/S phase transition; phosphorylated during S phase in a Cdc28p-dependent manner; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus.


ensembl_gene_id: YPL015C
symbol: HST2
gene_biotype: protein_coding
description:
  Cytoplasmic NAD(+)-dependent protein deacetylase; deacetylation targets are primarily cytoplasmic proteins; member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro; contains a nuclear export signal (NES); function regulated by its nuclear export; Belongs to the sirtuin family. Class I subfamily.


ensembl_gene_id: YPL016W
symbol: SWI1
gene_biotype: protein_coding
description:
  Subunit of the SWI/SNF chromatin remodeling complex; regulates transcription by remodeling chromatin; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; self-assembles to form [SWI+] prion and to alter expression pattern; human homolog ARID1A is a candidate tumor suppressor gene in breast cancer; Belongs to the SWI1 family.


ensembl_gene_id: YPL017C
symbol: IRC15
gene_biotype: protein_coding
description:
  Increased recombination centers protein 15; Microtubule associated protein; regulates microtubule dynamics; required for accurate meiotic chromosome segregation; null mutant displays large budded cells due to delayed mitotic progression, increased levels of spontaneous Rad52 foci; IRC15 has a paralog, LPD1, that arose from the whole genome duplication; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.


ensembl_gene_id: YPL018W
symbol: CTF19
gene_biotype: protein_coding
description:
  Inner kinetochore subunit CTF19; Outer kinetochore protein, needed for accurate chromosome segregation; component of kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as platform for kinetochore assembly; required for spindle assembly checkpoint; minimizes potentially deleterious centromere-proximal crossovers by preventing meiotic DNA break formation proximal to centromere; homolog of human centromere constitutive-associated network (CCAN) subunit CENP-P and fission yeast fta2.


ensembl_gene_id: YPL019C
symbol: VTC3
gene_biotype: protein_coding
description:
  Regulatory subunit of the vacuolar transporter chaperone (VTC) complex; involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion; VTC3 has a paralog, VTC2, that arose from the whole genome duplication; Belongs to the VTC2/3 family.


ensembl_gene_id: YPL020C
symbol: ULP1
gene_biotype: protein_coding
description:
  Ubiquitin-like-specific protease 1; Protease that specifically cleaves Smt3p protein conjugates; required for cell cycle progression; associates with nucleoporins and may interact with septin rings during telophase; sequestered to the nucleolus under stress conditions.


ensembl_gene_id: YPL021W
symbol: ECM23
gene_biotype: protein_coding
description:
  Non-essential protein of unconfirmed function; affects pre-rRNA processing, may act as a negative regulator of the transcription of genes involved in pseudohyphal growth; homologous to Srd1p.


ensembl_gene_id: YPL022W
symbol: RAD1
gene_biotype: protein_coding
description:
  Single-stranded DNA endonuclease (with Rad10p); cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human XPF protein.


ensembl_gene_id: YPL023C
symbol: MET12
gene_biotype: protein_coding
description:
  Methylenetetrahydrofolate reductase 1; Protein with MTHFR activity in vitro; null mutant has no phenotype and is prototrophic for methionine; MET13 encodes major isozyme of methylenetetrahydrofolate reductase (MTHFR).


ensembl_gene_id: YPL024W
symbol: RMI1
gene_biotype: protein_coding
description:
  RecQ-mediated genome instability protein 1; Subunit of the RecQ (Sgs1p) - Topo III (Top3p) complex; stimulates superhelical relaxing, DNA catenation/decatenation and ssDNA binding activities of Top3p; involved in response to DNA damage; functions in S phase-mediated cohesion establishment via a pathway involving the Ctf18-RFC complex and Mrc1p; stimulates Top3p DNA catenation/decatenation activity; null mutants display increased rates of recombination and delayed S phase.


ensembl_gene_id: YPL025C
symbol: YPL025C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YPL025C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YPL026C
symbol: SKS1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase SKS1; Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway; SKS1 has a paralog, VHS1, that arose from the whole genome duplication.


ensembl_gene_id: YPL027W
symbol: SMA1
gene_biotype: protein_coding
description:
  Protein of unknown function involved in prospore membrane assembly; involved in the assembly of the prospore membrane during sporulation; interacts with Spo14p.


ensembl_gene_id: YPL028W
symbol: ERG10
gene_biotype: protein_coding
description:
  Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase); cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis; human ACAT1 functionally complements the growth defect caused by repression of ERG10 expression; Belongs to the thiolase-like superfamily. Thiolase family.


ensembl_gene_id: YPL029W
symbol: SUV3
gene_biotype: protein_coding
description:
  ATP-dependent RNA helicase; component of the mitochondrial degradosome along with the RNase Dss1p; the degradosome associates with the ribosome and mediates RNA turnover; also required during splicing of the COX1 AI5_beta intron; expression of a processed form of human homolog SUPV3L1 carrying an N-terminal deletion of 46 amino acids rescues yeast suv3 null mutant.


ensembl_gene_id: YPL030W
symbol: TRM44
gene_biotype: protein_coding
description:
  tRNA(Ser) Um(44) 2'-O-methyltransferase; involved in maintaining levels of the tRNA-Ser species tS(CGA) and tS(UGA); conserved among metazoans and fungi but there does not appear to be a homolog in plants; TRM44 is a non-essential gene.


ensembl_gene_id: YPL031C
symbol: PHO85
gene_biotype: protein_coding
description:
  Cyclin-dependent kinase; has ten cyclin partners; involved in regulating the cellular response to nutrient levels and environmental conditions and progression through the cell cycle; human lissencephaly-associated homolog CDK5 functionally complements null mutation; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.


ensembl_gene_id: YPL032C
symbol: SVL3
gene_biotype: protein_coding
description:
  Styryl dye vacuolar localization protein 3; Protein of unknown function; mutant phenotype suggests a potential role in vacuolar function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; relocalizes from bud neck to cytoplasm upon DNA replication stress; SVL3 has a paralog, PAM1, that arose from the whole genome duplication.


ensembl_gene_id: YPL033C
symbol: SRL4
gene_biotype: protein_coding
description:
  Oxidoreductase-like protein SRL4; Protein of unknown function; involved in regulation of dNTP production; null mutant suppresses the lethality of lcd1 and rad53 mutations; expression is induced by Kar4p.


ensembl_gene_id: YPL035C
symbol: YPL035C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YPL035C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YPL034W; YPL035C is not an essential gene.


ensembl_gene_id: YPL036W
symbol: PMA2
gene_biotype: protein_coding
description:
  Plasma membrane H+-ATPase; isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.


ensembl_gene_id: YPL037C
symbol: EGD1
gene_biotype: protein_coding
description:
  Subunit beta1 of the nascent polypeptide-associated complex (NAC); involved in protein targeting, associated with cytoplasmic ribosomes; enhances DNA binding of the Gal4p activator; homolog of human BTF3b; EGD1 has a paralog, BTT1, that arose from the whole genome duplication; Belongs to the NAC-beta family.


ensembl_gene_id: YPL038W
symbol: MET31
gene_biotype: protein_coding
description:
  Transcriptional regulator MET31; Zinc-finger DNA-binding transcription factor; targets strong transcriptional activator Met4p to promoters of sulfur metabolic genes; involved in transcriptional regulation of the methionine biosynthetic genes; feedforward loop controlling expression of MET32 and the lack of such a loop for MET31 may account for the differential actions of Met31p and Met32p; MET31 has a paralog, MET32, that arose from the whole genome duplication.


ensembl_gene_id: YPL038W-A
symbol: YPL038W-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YPL038W-A; Putative protein of unknown function; identified by fungal homology and RT-PCR.


ensembl_gene_id: YPL040C
symbol: ISM1
gene_biotype: protein_coding
description:
  Isoleucine--tRNA ligase, mitochondrial; Mitochondrial isoleucyl-tRNA synthetase; null mutant is deficient in respiratory growth; human homolog IARS2 implicated in mitochondrial diseases, can partially complement yeast null mutant.


ensembl_gene_id: YPL041C
symbol: MRX11
gene_biotype: protein_coding
description:
  MIOREX complex component 11; Protein that associates with mitochondrial ribosome; SWAT-GFP and mCherry fusion proteins localize to the mitochondria; involved in maintenance of telomere length.


ensembl_gene_id: YPL042C
symbol: SSN3
gene_biotype: protein_coding
description:
  Meiotic mRNA stability protein kinase SSN3; Cyclin-dependent protein kinase; component of RNA polymerase II holoenzyme; involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression.


ensembl_gene_id: YPL043W
symbol: NOP4
gene_biotype: protein_coding
description:
  Nucleolar protein; essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs (RRMs).


ensembl_gene_id: YPL044C
symbol: YPL044C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YPL044C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP4/YPL043W.


ensembl_gene_id: YPL045W
symbol: VPS16
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 16; Subunit of the HOPS and the CORVET complexes; part of the Class C Vps complex essential for membrane docking and fusion at Golgi-to-endosome and endosome-to-vacuole protein transport stages.


ensembl_gene_id: YPL046C
symbol: ELC1
gene_biotype: protein_coding
description:
  Elongin-C; Elongin C, conserved among eukaryotes; forms a complex with Cul3p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; plays a role in global genomic repair.


ensembl_gene_id: YPL047W
symbol: SGF11
gene_biotype: protein_coding
description:
  SAGA-associated factor 11; Integral subunit of SAGA histone acetyltransferase complex; regulates transcription of a subset of SAGA-regulated genes, required for the Ubp8p association with SAGA and for H2B deubiquitylation.


ensembl_gene_id: YPL048W
symbol: CAM1
gene_biotype: protein_coding
description:
  Elongation factor 1-gamma 1; One of two isoforms of the gamma subunit of eEF1B; stimulates the release of GDP from eEF1A (Tef1p/Tef2p) post association with the ribosomal complex with eEF1Balpha subunit; nuclear protein required for transcription of MXR1; binds the MXR1 promoter in the presence of other nuclear factors; binds calcium and phospholipids.


ensembl_gene_id: YPL049C
symbol: DIG1
gene_biotype: protein_coding
description:
  Down-regulator of invasive growth 1; MAP kinase-responsive inhibitor of the Ste12p transcription factor; involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p; DIG1 has a paralog, DIG2, that arose from the whole genome duplication.


ensembl_gene_id: YPL050C
symbol: MNN9
gene_biotype: protein_coding
description:
  Mannan polymerase complexes subunit MNN9; Subunit of Golgi mannosyltransferase complex; this complex mediates elongation of the polysaccharide mannan backbone; forms a separate complex with Van1p that is also involved in backbone elongation; this complex also contains Anp1p, Mnn10p, Mnn11p, and Hoc1p; Belongs to the ANP1/MMN9/VAN1 family.


ensembl_gene_id: YPL051W
symbol: ARL3
gene_biotype: protein_coding
description:
  ADP-ribosylation factor-like protein 3; ARF-like small GTPase of the RAS superfamily; required for recruitment of Arl1p, a GTPase that regulates membrane traffic, to the Golgi apparatus; NatC-catalyzed N-terminal acetylation regulates Golgi membrane association mediated by interaction with membrane receptor, Sys1p; similar to ADP-ribosylation factor and orthologous to mammalian ARFRP1.


ensembl_gene_id: YPL052W
symbol: OAZ1
gene_biotype: protein_coding
description:
  Regulator of ornithine decarboxylase Spe1p; antizyme that binds to Spe1p to stimulate ubiquitin-independent degradation by the proteasome; binding of polyamines to nascent Oaz1p during translation stimulates +1 ribosomal frameshifting, allowing translation of full-length Oaz1p.


ensembl_gene_id: YPL053C
symbol: KTR6
gene_biotype: protein_coding
description:
  Mannosyltransferase KTR6; Probable mannosylphosphate transferase; involved in the synthesis of core oligosaccharides in protein glycosylation pathway; member of the KRE2/MNT1 mannosyltransferase family; KTR6 has a paralog, KRE2, that arose from the whole genome duplication; Belongs to the glycosyltransferase 15 family.


ensembl_gene_id: YPL055C
symbol: LGE1
gene_biotype: protein_coding
description:
  Transcriptional regulatory protein LGE1; Protein of unknown function; null mutant forms abnormally large cells, and homozygous diploid null mutant displays delayed premeiotic DNA synthesis and reduced efficiency of meiotic nuclear division.


ensembl_gene_id: YPL056C
symbol: LCL1
gene_biotype: protein_coding
description:
  Long chronological lifespan protein 1; Putative protein of unknown function; deletion mutant is fluconazole resistant and has long chronological lifespan.


ensembl_gene_id: YPL057C
symbol: SUR1
gene_biotype: protein_coding
description:
  Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; SUR1 has a paralog, CSH1, that arose from the whole genome duplication.


ensembl_gene_id: YPL058C
symbol: PDR12
gene_biotype: protein_coding
description:
  ATP-dependent permease PDR12; Plasma membrane ATP-binding cassette (ABC) transporter; weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and benzoate and regulated by War1p; mutants exhibit sorbate hypersensitivity.


ensembl_gene_id: YPL059W
symbol: GRX5
gene_biotype: protein_coding
description:
  Monothiol glutaredoxin-5, mitochondrial; Glutathione-dependent oxidoreductase; mitochondrial matrix protein involved at an early step in the biogenesis of iron-sulfur centers along with Bol1p; hydroperoxide and superoxide-radical responsive; monothiol glutaredoxin subfamily member along with Grx3p and Grx4p.


ensembl_gene_id: YPL060W
symbol: MFM1
gene_biotype: protein_coding
description:
  Mitochondrial inner membrane magnesium transporter; involved in maintenance of mitochondrial magnesium concentrations and membrane potential; indirectly affects splicing of group II introns; functionally and structurally related to Mrs2p; Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.


ensembl_gene_id: YPL061W
symbol: ALD6
gene_biotype: protein_coding
description:
  Cytosolic aldehyde dehydrogenase; activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stress.


ensembl_gene_id: YPL062W
symbol: YPL062W
gene_biotype: protein_coding
description:
  Uncharacterized protein YPL062W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; YPL062W is not an essential gene; homozygous diploid mutant shows a decrease in glycogen accumulation.


ensembl_gene_id: YPL063W
symbol: TIM50
gene_biotype: protein_coding
description:
  Essential component of the TIM23 complex; acts as receptor for the translocase of the inner mitochondrial membrane (TIM23) complex guiding incoming precursors from the TOM complex; may control the gating of the Tim23p-Tim17p channel.


ensembl_gene_id: YPL064C
symbol: CWC27
gene_biotype: protein_coding
description:
  Peptidyl-prolyl isomerase CWC27; Component of a complex containing Cef1p; putatively involved in pre-mRNA splicing; has similarity to S. pombe Cwf27p; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YPL065W
symbol: VPS28
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 28; Component of the ESCRT-I complex; complex is involved in ubiquitin-dependent sorting of proteins into the endosome; conserved C-terminal domain interacts with ESCRT-III subunit Vps20p; other members include Stp22p, Srn2p, Vps28p, and Mvb12p.


ensembl_gene_id: YPL066W
symbol: RGL1
gene_biotype: protein_coding
description:
  RHO1 GEF localizing protein 1; Regulator of Rho1p signaling, cofactor of Tus1p; required for the localization of Tus1p during all phases of cytokinesis; green fluorescent protein (GFP)-fusion protein localizes to the bud neck and cytoplasm; null mutant is viable and exhibits growth defect on a non-fermentable (respiratory) carbon source.


ensembl_gene_id: YPL067C
symbol: YPL067C
gene_biotype: protein_coding
description:
  Uncharacterized protein YPL067C; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL067C is not an essential gene.


ensembl_gene_id: YPL068C
symbol: YPL068C
gene_biotype: protein_coding
description:
  Uncharacterized protein YPL068C; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and is induced in response to the DNA-damaging agent MMS.


ensembl_gene_id: YPL069C
symbol: BTS1
gene_biotype: protein_coding
description:
  Geranylgeranyl diphosphate synthase (GGPS); increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic.


ensembl_gene_id: YPL070W
symbol: MUK1
gene_biotype: protein_coding
description:
  Protein MUK1; Guanine nucleotide exchange factor (GEF); involved in vesicle-mediated vacuolar transport, including Golgi-endosome trafficking and sorting through the multivesicular body (MVB); specifically stimulates the intrinsic guanine nucleotide exchange activity of Rab family members (Vps21p/Ypt52p/Ypt53p); partially redundant with GEF VPS9; required for localization of the CORVET complex to endosomes; contains a VPS9 domain.


ensembl_gene_id: YPL071C
symbol: YPL071C
gene_biotype: protein_coding
description:
  Uncharacterized protein YPL071C; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus.


ensembl_gene_id: YPL072W
symbol: UBP16
gene_biotype: protein_coding
description:
  Ubiquitin carboxyl-terminal hydrolase 16; Deubiquitinating enzyme anchored to the outer mitochondrial membrane; probably not important for general mitochondrial functioning, but may perform a more specialized function at mitochondria; Belongs to the peptidase C19 family.


ensembl_gene_id: YPL073C
symbol: YPL073C
gene_biotype: protein_coding
description:
  Uncharacterized protein YPL073C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps with verified gene UBP16/YPL072W; may interact with ribosome based on co-purification experiments.


ensembl_gene_id: YPL074W
symbol: YTA6
gene_biotype: protein_coding
description:
  Probable 26S proteasome subunit YTA6; Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family; localized to the cortex of mother cells but not to daughter cells; relocalizes from cytoplasm to plasma membrane foci upon DNA replication stress.


ensembl_gene_id: YPL075W
symbol: GCR1
gene_biotype: protein_coding
description:
  Transcriptional activator of genes involved in glycolysis; DNA-binding protein that interacts and functions with the transcriptional activator Gcr2p.


ensembl_gene_id: YPL076W
symbol: GPI2
gene_biotype: protein_coding
description:
  Phosphatidylinositol N-acetylglucosaminyltransferase GPI2 subunit; Protein involved in the synthesis of GlcNAc-PI; GlcNAc-PI is the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-C protein; GlcNAc-PI stands for N-acetylglucosaminyl phosphatidylinositol.


ensembl_gene_id: YPL077C
symbol: YPL077C
gene_biotype: protein_coding
description:
  Uncharacterized protein YPL077C; Putative protein of unknown function; regulates PIS1 expression; mutant displays spore wall assembly defect in ether sensitivity screen; YPL077C is not an essential gene; YPL077C has a paralog, YBR197C, that arose from the whole genome duplication.


ensembl_gene_id: YPL078C
symbol: ATP4
gene_biotype: protein_coding
description:
  Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase; ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; contributes to the oligomerization of the complex, which in turn determines the shape of inner membrane cristae; phosphorylated; Belongs to the eukaryotic ATPase B chain family.


ensembl_gene_id: YPL079W
symbol: RPL21B
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L21B; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21B has a paralog, RPL21A, that arose from the whole genome duplication.


ensembl_gene_id: YPL080C
symbol: YPL080C
gene_biotype: protein_coding
description:
  Uncharacterized protein YPL080C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YPL081W
symbol: RPS9A
gene_biotype: protein_coding
description:
  Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9A has a paralog, RPS9B, that arose from the whole genome duplication.


ensembl_gene_id: YPL082C
symbol: MOT1
gene_biotype: protein_coding
description:
  TATA-binding protein-associated factor MOT1; Essential protein involved in regulation of transcription; removes Spt15p (TBP) from DNA via its C-terminal ATPase activity; may have a role in ensuring that soluble TBP is available to bind TATA-less promoters; forms a complex with TBP that binds TATA DNA with high affinity but with altered specificity; the Mot1p-Spt15p-DNA ternary complex contains unbent DNA; coregulates transcription with Spt16p through assembly of preinitiation complex and organization of nucleosomes.


ensembl_gene_id: YPL084W
symbol: BRO1
gene_biotype: protein_coding
description:
  Vacuolar-sorting protein BRO1; Cytoplasmic class E vacuolar protein sorting (VPS) factor; coordinates deubiquitination in the multivesicular body (MVB) pathway by recruiting Doa4p to endosomes.


ensembl_gene_id: YPL085W
symbol: SEC16
gene_biotype: protein_coding
description:
  COPII vesicle coat protein required for ER transport vesicle budding; essential factor in endoplasmic reticulum exit site (ERES) formation, as well as in COPII-mediated ER-to-Golgi traffic; bound to periphery of ER membranes and may act to stabilize initial COPII complexes; interacts with Sec23p, Sec24p and Sec31p.


ensembl_gene_id: YPL086C
symbol: ELP3
gene_biotype: protein_coding
description:
  Subunit of Elongator complex; Elongator is required for modification of wobble nucleosides in tRNA; exhibits histone acetyltransferase activity that is directed to histones H3 and H4; disruption confers resistance to K. lactis zymotoxin; human homolog ELP3 can partially complement yeast elp3 null mutant; Belongs to the ELP3 family.


ensembl_gene_id: YPL087W
symbol: YDC1
gene_biotype: protein_coding
description:
  Alkaline dihydroceramidase, involved in sphingolipid metabolism; preferentially hydrolyzes dihydroceramide to a free fatty acid and dihydrosphingosine; has a minor reverse activity; YDC1 has a paralog, YPC1, that arose from the whole genome duplication.


ensembl_gene_id: YPL088W
symbol: YPL088W
gene_biotype: protein_coding
description:
  Putative aryl alcohol dehydrogenase; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.


ensembl_gene_id: YPL089C
symbol: RLM1
gene_biotype: protein_coding
description:
  MADS-box transcription factor; component of the protein kinase C-mediated MAP kinase pathway involved in the maintenance of cell integrity; phosphorylated and activated by the MAP-kinase Slt2p; RLM1 has a paralog, SMP1, that arose from the whole genome duplication.


ensembl_gene_id: YPL090C
symbol: RPS6A
gene_biotype: protein_coding
description:
  Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; phosphorylated on S233 by Ypk3p in a TORC1-dependent manner, and on S232 in a TORC1/2-dependent manner by Ypk1/2/3p; RPS6A has a paralog, RPS6B, that arose from the whole genome duplication.


ensembl_gene_id: YPL091W
symbol: GLR1
gene_biotype: protein_coding
description:
  Cytosolic and mitochondrial glutathione oxidoreductase; converts oxidized glutathione to reduced glutathione; cytosolic Glr1p is the main determinant of the glutathione redox state of the mitochondrial intermembrane space; mitochondrial Glr1p has a role in resistance to hyperoxia; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YPL092W
symbol: SSU1
gene_biotype: protein_coding
description:
  Plasma membrane sulfite pump involved in sulfite metabolism; required for efficient sulfite efflux; major facilitator superfamily protein; Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.


ensembl_gene_id: YPL093W
symbol: NOG1
gene_biotype: protein_coding
description:
  Nucleolar GTP-binding protein 1; Putative GTPase; associates with free 60S ribosomal subunits in the nucleolus and is required for 60S ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; member of the ODN family of nucleolar G-proteins.


ensembl_gene_id: YPL094C
symbol: SEC62
gene_biotype: protein_coding
description:
  Translocation protein SEC62; Essential subunit of Sec63 complex; with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER; cotranslationally N-acetylated by NatA; other members are Sec63p, Sec66p, and Sec72p.


ensembl_gene_id: YPL095C
symbol: EEB1
gene_biotype: protein_coding
description:
  Acyl-coenzymeA:ethanol O-acyltransferase; responsible for the major part of medium-chain fatty acid ethyl ester biosynthesis during fermentation; possesses short-chain esterase activity; may be involved in lipid metabolism and detoxification; EEB1 has a paralog, EHT1, that arose from the whole genome duplication.


ensembl_gene_id: YPL096C-A
symbol: ERI1
gene_biotype: protein_coding
description:
  Phosphatidylinositol N-acetylglucosaminyltransferase ERI1 subunit; Endoplasmic reticulum membrane protein that binds and inhibits Ras2p; binds to and inhibits GTP-bound Ras2p at the endoplasmic reticulum (ER); component of the GPI-GnT complex which catalyzes the first step in GPI-anchor biosynthesis; probable homolog of mammalian PIG-Y protein.


ensembl_gene_id: YPL096W
symbol: PNG1
gene_biotype: protein_coding
description:
  Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase; Conserved peptide N-glycanase; deglycosylating enzyme that cleaves N-glycans that are attached to misfolded ERAD substrate glycoproteins prior to proteasome-dependent degradation; localizes to the cytoplasm and nucleus; activity is enhanced by interaction with Rad23p; human ortholog NGLY1 is associated with a syndrome characterized by developmental delays, epilepsy, absence of tears and liver disease; Belongs to the transglutaminase-like superfamily. PNGase family.


ensembl_gene_id: YPL098C
symbol: MGR2
gene_biotype: protein_coding
description:
  Protein MGR2; Subunit of the TIM23 translocase complex; acts to couple Tim21p with the core Tim23 translocase; provides quality control for insertion of membrane proteins by regulating their release into the inner membrane by the TIM23 complex; absolutely required for mitochondrial import of presequence-containing proteins at elevated temperature; required for viability of cells lacking the mitochondrial genome (petite-negative phenotype); Belongs to the MGR2 family.


ensembl_gene_id: YPL099C
symbol: INA17
gene_biotype: protein_coding
description:
  Inner membrane assembly complex subunit 17; F1F0 ATPase synthase peripheral stalk assembly factor; subunit of the matrix-exposed inner mitochondrial membrane localized INA complex (Ina22p-Ina17p) involved in assembly of the F1F0 peripheral stalk; co-purifies with Ina22p and ATP synthase subunits; null mutant displays elevated frequency of mitochondrial genome loss and has a respiratory growth defect.


ensembl_gene_id: YPL100W
symbol: ATG21
gene_biotype: protein_coding
description:
  Autophagy-related protein 21; Phosphoinositide binding protein; required for vesicle formation in the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein.


ensembl_gene_id: YPL101W
symbol: ELP4
gene_biotype: protein_coding
description:
  Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity; null mutation is functionally complemented by human ELP4; Belongs to the ELP4 family.


ensembl_gene_id: YPL102C
symbol: YPL102C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YPL102C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; deletion mutation enhances replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene ELP4.


ensembl_gene_id: YPL103C
symbol: FMP30
gene_biotype: protein_coding
description:
  N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D, mitochondrial; Protein with a role in maintaining mitochondrial morphology; also involved in maintaining normal cardiolipin levels; mitochondrial inner membrane protein; proposed to be involved in N-acylethanolamine metabolism; related to mammalian N-acylPE-specific phospholipase D; Belongs to the NAPE-PLD family.


ensembl_gene_id: YPL104W
symbol: MSD1
gene_biotype: protein_coding
description:
  Aspartate--tRNA ligase, mitochondrial; Mitochondrial aspartyl-tRNA synthetase; required for acylation of aspartyl-tRNA; yeast and bacterial aspartyl-, asparaginyl-, and lysyl-tRNA synthetases contain regions with high sequence similarity, suggesting a common ancestral gene.


ensembl_gene_id: YPL105C
symbol: SYH1
gene_biotype: protein_coding
description:
  SMY2 homolog 2; Protein of unknown function that influences nuclear pore distribution; co-purifies with ribosomes; contains a GYF domain, which bind proline-rich sequences; deletion extends chronological lifespan; SYH1 has a paralog, SMY2, that arose from the whole genome duplication.


ensembl_gene_id: YPL106C
symbol: SSE1
gene_biotype: protein_coding
description:
  ATPase component of heat shock protein Hsp90 chaperone complex; serves as nucleotide exchange factor to load ATP onto the SSA class of cytosolic Hsp70s; plays a role in prion propagation and determining prion variants; binds unfolded proteins; member of Hsp110 subclass of HSP70 proteins; deletion results in spindle elongation in S phase; SSE1 has a paralog, SSE2, that arose from the whole genome duplication.


ensembl_gene_id: YPL107W
symbol: YPL107W
gene_biotype: protein_coding
description:
  UPF0651 protein YPL107W, mitochondrial; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YPL107W is not an essential gene; Belongs to the UPF0651 family.


ensembl_gene_id: YPL108W
symbol: YPL108W
gene_biotype: protein_coding
description:
  Uncharacterized protein YPL108W; Cytoplasmic protein of unknown function; non-essential gene that is induced in a GDH1 deleted strain with altered redox metabolism; GFP-fusion protein is induced in response to the DNA-damaging agent MMS.


ensembl_gene_id: YPL109C
symbol: YPL109C
gene_biotype: protein_coding
description:
  UbiB family protein; contains transmembrane domain and mitochondrial targeting sequence; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Belongs to the protein kinase superfamily. ADCK protein kinase family.


ensembl_gene_id: YPL110C
symbol: GDE1
gene_biotype: protein_coding
description:
  Glycerophosphocholine (GroPCho) phosphodiesterase; hydrolyzes GroPCho to choline and glycerolphosphate, for use as a phosphate source and as a precursor for phosphocholine synthesis; may interact with ribosomes.


ensembl_gene_id: YPL111W
symbol: CAR1
gene_biotype: protein_coding
description:
  Arginase, catabolizes arginine to ornithine and urea; expression responds to both induction by arginine and nitrogen catabolite repression; disruption decreases production of carcinogen ethyl carbamate during wine fermentation and also enhances freeze tolerance.


ensembl_gene_id: YPL112C
symbol: PEX25
gene_biotype: protein_coding
description:
  Peripheral peroxisomal membrane peroxin; required for the regulation of peroxisome size and maintenance, recruits GTPase Rho1p to peroxisomes, induced by oleate, interacts with Pex27p; PEX25 has a paralog, PEX27, that arose from the whole genome duplication.


ensembl_gene_id: YPL113C
symbol: YPL113C
gene_biotype: protein_coding
description:
  Putative 2-hydroxyacid dehydrogenase YPL113C; Glyoxylate reductase; acts on glyoxylate and hydroxypyruvate substrates; YPL113C is not an essential gene; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.


ensembl_gene_id: YPL114W
symbol: YPL114W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YPL114W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; largely overlaps ORF YPL113C; diploid deletion in BY4743 strain background exhibits high budding index.


ensembl_gene_id: YPL115C
symbol: BEM3
gene_biotype: protein_coding
description:
  GTPase-activating protein BEM3; Rho GTPase activating protein (RhoGAP); involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly.


ensembl_gene_id: YPL116W
symbol: HOS3
gene_biotype: protein_coding
description:
  Histone deacetylase HOS3; Trichostatin A-insensitive homodimeric histone deacetylase (HDAC); specificity in vitro for histones H3, H4, H2A, and H2B; similar to Hda1p, Rpd3p, Hos1p, and Hos2p; deletion results in increased histone acetylation at rDNA repeats.


ensembl_gene_id: YPL117C
symbol: IDI1
gene_biotype: protein_coding
description:
  Isopentenyl-diphosphate Delta-isomerase; Isopentenyl diphosphate:dimethylallyl diphosphate isomerase; catalyzes an essential activation step in the isoprenoid biosynthetic pathway; required for viability; isopentenyl diphosphate:dimethylallyl diphosphate isomerase is also known as IPP isomerase; Belongs to the IPP isomerase type 1 family.


ensembl_gene_id: YPL118W
symbol: MRP51
gene_biotype: protein_coding
description:
  Mitochondrial ribosomal protein of the small subunit; MRP51 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences.


ensembl_gene_id: YPL119C
symbol: DBP1
gene_biotype: protein_coding
description:
  Putative ATP-dependent RNA helicase of the DEAD-box protein family; mutants show reduced stability of the 40S ribosomal subunit scanning through 5' untranslated regions of mRNAs; protein abundance increases in response to DNA replication stress; DBP1 has a paralog, DED1, that arose from the whole genome duplication.


ensembl_gene_id: YPL119C-A
symbol: YPL119C-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YPL119C-A; Putative protein of unknown function; identified by expression profiling and mass spectrometry.


ensembl_gene_id: YPL120W
symbol: VPS30
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 30; Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II; Complex I is essential in autophagy, Complex II is required for vacuolar protein sorting; required for overflow degradation of misfolded proteins when ERAD is saturated; C-terminus has novel globular fold essential for autophagy through the targeting of the PI3-kinase complex I to the pre-autophagosomal structure; ortholog of higher eukaryote gene Beclin 1; human BECN1 can complement yeast null mutant.


ensembl_gene_id: YPL121C
symbol: MEI5
gene_biotype: protein_coding
description:
  Meiosis-specific protein involved in meiotic recombination; involved in DMC1-dependent meiotic recombination; forms heterodimer with Sae3p; proposed to be an assembly factor for Dmc1p; Belongs to the SFR1/MEI5 family.


ensembl_gene_id: YPL122C
symbol: TFB2
gene_biotype: protein_coding
description:
  Subunit of TFIIH and nucleotide excision repair factor 3 complexes; involved in transcription initiation, required for nucleotide excision repair, similar to 52 kDa subunit of human TFIIH.


ensembl_gene_id: YPL123C
symbol: RNY1
gene_biotype: protein_coding
description:
  Ribonuclease T2-like; Vacuolar RNase of the T(2) family; relocalizes to the cytosol where it cleaves tRNAs upon oxidative or stationary phase stress; required for tRNA-specific translational pausing suring oxidative stress; promotes apoptosis under stress conditions and this function is independent of Rny1p catalytic activity.


ensembl_gene_id: YPL124W
symbol: SPC29
gene_biotype: protein_coding
description:
  Inner plaque spindle pole body (SPB) component; links the central plaque component Spc42p to the inner plaque component Spc110p; required for SPB duplication.


ensembl_gene_id: YPL125W
symbol: KAP120
gene_biotype: protein_coding
description:
  Importin beta-like protein KAP120; Karyopherin responsible for the nuclear import of Rpf1p; Rpf1p is a ribosome maturation factor; Belongs to the importin beta family.


ensembl_gene_id: YPL126W
symbol: NAN1
gene_biotype: protein_coding
description:
  NET1-associated nuclear protein 1; U3 snoRNP protein; component of the small (ribosomal) subunit (SSU) processosome containing U3 snoRNA; required for the biogenesis of18S rRNA.


ensembl_gene_id: YPL127C
symbol: HHO1
gene_biotype: protein_coding
description:
  Histone H1, linker histone with roles in meiosis and sporulation; decreasing levels early in sporulation may promote meiosis, and increasing levels during sporulation facilitate compaction of spore chromatin; binds to promoters and within genes in mature spores; may be recruited by Ume6p to promoter regions, contributing to transcriptional repression outside of meiosis; suppresses DNA repair involving homologous recombination; Belongs to the histone H1/H5 family.


ensembl_gene_id: YPL128C
symbol: TBF1
gene_biotype: protein_coding
description:
  Protein TBF1; Telobox-containing general regulatory factor; binds TTAGGG repeats within subtelomeric anti-silencing regions (STARs), blocking silent chromatin propagation; binds majority of snoRNA gene promoters, required for full snoRNA expression; caps DSB flanked by long T2AG3 repeats and blocks checkpoint activation.


ensembl_gene_id: YPL129W
symbol: TAF14
gene_biotype: protein_coding
description:
  Transcription initiation factor TFIID subunit 14; Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes; involved in RNA polymerase II transcription initiation and in chromatin modification; contains a YEATS domain; Belongs to the TAF14 family.


ensembl_gene_id: YPL130W
symbol: SPO19
gene_biotype: protein_coding
description:
  Sporulation-specific protein 19; Meiosis-specific prospore protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation; identified as a weak high-copy suppressor of the spo1-1 ts mutation; SPO19 has a paralog, YOR214C, that arose from the whole genome duplication.


ensembl_gene_id: YPL131W
symbol: RPL5
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L5; nascent Rpl5p is bound by specific chaperone Syo1p during translation; homologous to mammalian ribosomal protein L5 and bacterial L18; binds 5S rRNA and is required for 60S subunit assembly; Belongs to the universal ribosomal protein uL18 family.


ensembl_gene_id: YPL132W
symbol: COX11
gene_biotype: protein_coding
description:
  Cytochrome c oxidase assembly protein COX11, mitochondrial; Protein required for delivery of copper to Cox1p; mitochondrial inner membrane protein; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p; Belongs to the COX11/CtaG family.


ensembl_gene_id: YPL133C
symbol: RDS2
gene_biotype: protein_coding
description:
  Regulator of drug sensitivity 2; Transcription factor involved in regulating gluconeogenesis; also involved in the regulation of glyoxylate cycle genes; member of the zinc cluster family of proteins; confers resistance to ketoconazole.


ensembl_gene_id: YPL134C
symbol: ODC1
gene_biotype: protein_coding
description:
  Mitochondrial inner membrane transporter; 2-oxodicarboxylate transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation; ODC1 has a paralog, ODC2, that arose from the whole genome duplication.


ensembl_gene_id: YPL135C-A
symbol: YPL135C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YPL135C-A; Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching.


ensembl_gene_id: YPL135W
symbol: ISU1
gene_biotype: protein_coding
description:
  Conserved protein of the mitochondrial matrix; performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); ISU1 has a paralog, ISU2, that arose from the whole genome duplication; isu1 isu2 double mutant is inviable; human homolog ISCU implicated in mitochondrial myopathy, can complement isu1 isu2 double mutant; Belongs to the NifU family.


ensembl_gene_id: YPL136W
symbol: YPL136W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YPL136W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified gene GIP3/YPL137C.


ensembl_gene_id: YPL137C
symbol: GIP3
gene_biotype: protein_coding
description:
  GLC7-interacting protein 3; Cytoplasmic protein that regulates protein phosphatase 1 Glc7p; overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; may interact with ribosomes, based on co-purification experiments; GIP3 has a paralog, HER1, that arose from the whole genome duplication.


ensembl_gene_id: YPL138C
symbol: SPP1
gene_biotype: protein_coding
description:
  COMPASS component SPP1; Subunit of COMPASS (Set1C); a complex which methylates histone H3 on lysine 4 and is required in telomeric transcriptional silencing; promotes meiotic DSB formation by interacting with H3K4me3 and Rec107p, a protein required for Spo11p-catalyzed DSB formation located on chromosome axes; interacts with Orc2p; PHD finger domain protein similar to human CGBP, an unmethylated CpG binding protein; relocalizes to cytosol in response to hypoxia.


ensembl_gene_id: YPL139C
symbol: UME1
gene_biotype: protein_coding
description:
  Transcriptional regulatory protein UME1; Component of both the Rpd3S and Rpd3L histone deacetylase complexes; negative regulator of meiosis; required for repression of a subset of meiotic genes during vegetative growth, binding of histone deacetylase Rpd3p required for activity, contains a NEE box and a WD repeat motif; homologous with Wtm1p; UME1 has a paralog, WTM2, that arose from the whole genome duplication.


ensembl_gene_id: YPL140C
symbol: MKK2
gene_biotype: protein_coding
description:
  MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk1p; MKK2 has a paralog, MKK1, that arose from the whole genome duplication.


ensembl_gene_id: YPL141C
symbol: FRK1
gene_biotype: protein_coding
description:
  Fatty acyl-CoA synthetase and RNA processing-associated kinase 1; Protein kinase of unknown cellular role; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; interacts with rRNA transcription and ribosome biogenesis factors and the long chain fatty acyl-CoA synthetase Faa3p; FRK1 has a paralog, KIN4, that arose from the whole genome duplication.


ensembl_gene_id: YPL142C
symbol: YPL142C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YPL142C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPL33A/YPL143W, a component of the large (60S) ribosomal subunit.


ensembl_gene_id: YPL143W
symbol: RPL33A
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L33A; N-terminally acetylated; rpl33a null mutant exhibits slow growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33A has a paralog, RPL33B, that arose from the whole genome duplication.


ensembl_gene_id: YPL144W
symbol: POC4
gene_biotype: protein_coding
description:
  Proteasome chaperone 4; Component of a heterodimeric Poc4p-Irc25p chaperone; involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions; upregulates proteasome assembly in response to the unfolded protein response activated by mistargeting of proteins (UPRam).


ensembl_gene_id: YPL145C
symbol: KES1
gene_biotype: protein_coding
description:
  Oxysterol-binding protein homolog 4; One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication; Belongs to the OSBP family.


ensembl_gene_id: YPL146C
symbol: NOP53
gene_biotype: protein_coding
description:
  Nucleolar protein; involved in biogenesis of the 60S subunit of the ribosome; interacts with rRNA processing factors Cbf5p and Nop2p and with the nucleolar proteins Nop17p and Nip7p; null mutant is viable but growth is severely impaired; Belongs to the NOP53 family.


ensembl_gene_id: YPL147W
symbol: PXA1
gene_biotype: protein_coding
description:
  Peroxisomal long-chain fatty acid import protein 2; Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa2p; required for import of long-chain fatty acids into peroxisomes; similar to human adrenoleukodystrophy transporters ABCD1and ABCD2, and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder; human ABCD1 and ABCD2 can each partially complement yeast pxa1 pxa2 double null mutant; Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.


ensembl_gene_id: YPL148C
symbol: PPT2
gene_biotype: protein_coding
description:
  Mitochondrial holo-[acyl-carrier-protein] synthase; Phosphopantetheine:protein transferase (PPTase); activates mitochondrial acyl carrier protein (Acp1p) by phosphopantetheinylation; Belongs to the P-Pant transferase superfamily. AcpS family.


ensembl_gene_id: YPL149W
symbol: ATG5
gene_biotype: protein_coding
description:
  Autophagy protein 5; Conserved protein involved in autophagy and the Cvt pathway; undergoes conjugation with Atg12p to form a complex involved in Atg8p lipidation; Atg5p-Atg12p conjugate enhances E2 activity of Atg3 by rearranging its catalytic site, also forms a complex with Atg16p; the Atg5-Atg12/Atg16 complex binds to membranes and is essential for autophagosome formation; also involved in methionine restriction extension of chronological lifespan in an autophagy-dependent manner.


ensembl_gene_id: YPL150W
symbol: YPL150W
gene_biotype: protein_coding
description:
  Putative serine/threonine-protein kinase YPL150W; Protein kinase of unknown cellular role; binds phosphatidylinositols and cardiolipin in a large-scale study.


ensembl_gene_id: YPL151C
symbol: PRP46
gene_biotype: protein_coding
description:
  Pre-mRNA-splicing factor PRP46; Member of the NineTeen Complex (NTC); this complex contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs.


ensembl_gene_id: YPL152W
symbol: RRD2
gene_biotype: protein_coding
description:
  Serine/threonine-protein phosphatase 2A activator 2; Peptidyl-prolyl cis/trans-isomerase; also activates the phosphotyrosyl phosphatase activity of protein phosphatase 2A (PP2A); regulates G1 phase progression, the osmoresponse, microtubule dynamics; subunit of the Tap42p-Pph21p-Rrd2p complex; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YPL152W-A
symbol: YPL152W-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YPL152W-A; Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching.


ensembl_gene_id: YPL153C
symbol: RAD53
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase RAD53; DNA damage response protein kinase; required for cell-cycle arrest, regulation of copper genes in response to DNA damage; phosphorylates nuclear pores to counteract gene gating, preventing aberrant transitions at forks approaching transcribed genes; activates downstream kinase Dun1p; differentially senses mtDNA depletion, mitochondrial ROS; relocalizes to cytosol under hypoxia; human homolog CHEK2 implicated in breast cancer can complement yeast null mutant; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.


ensembl_gene_id: YPL154C
symbol: PEP4
gene_biotype: protein_coding
description:
  Saccharopepsin; Vacuolar aspartyl protease (proteinase A); required for posttranslational precursor maturation of vacuolar proteinases; important for protein turnover after oxidative damage; plays a protective role in acetic acid induced apoptosis; synthesized as a zymogen, self-activates.


ensembl_gene_id: YPL155C
symbol: KIP2
gene_biotype: protein_coding
description:
  Kinesin-like protein KIP2; Kinesin-related motor protein involved in mitotic spindle positioning; stabilizes microtubules by targeting Bik1p to the plus end; functions as a microtubule polymerase and catastrophe inhibitor in vitro; Kip2p levels are controlled during the cell cycle.


ensembl_gene_id: YPL156C
symbol: PRM4
gene_biotype: protein_coding
description:
  Pheromone-regulated protein proposed to be involved in mating; predicted to have 1 transmembrane segment; transcriptionally regulated by Ste12p during mating and by Cat8p during the diauxic shift.


ensembl_gene_id: YPL157W
symbol: TGS1
gene_biotype: protein_coding
description:
  Trimethyl guanosine synthase, conserved nucleolar methyl transferase; converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for nucleolar assembly and splicing of meiotic pre-mRNAs; interacts with Swm2p, which may confer substrate specificity on Tgs1p.


ensembl_gene_id: YPL158C
symbol: AIM44
gene_biotype: protein_coding
description:
  Altered inheritance of mitochondria protein 44; Protein that regulates Cdc42p and Rho1p; functions in the late steps of cytokinesis and cell separation; sustains Rho1p at the cell division site after actomyosin ring contraction; inhibits the activation of Cdc42-Cla4 at the cell division site to prevent budding inside the old bud neck; transcription is regulated by Swi5p; null mutant displays elevated frequency of mitochondrial genome loss; relocalizes from bud neck to cytoplasm upon DNA replication stress.


ensembl_gene_id: YPL159C
symbol: PET20
gene_biotype: protein_coding
description:
  Mitochondrial protein; required for respiratory growth under some conditions and for stability of the mitochondrial genome.


ensembl_gene_id: YPL160W
symbol: CDC60
gene_biotype: protein_coding
description:
  Leucine--tRNA ligase, cytoplasmic; Cytosolic leucyl tRNA synthetase; ligates leucine to the appropriate tRNA; human homolog LARS can complement yeast temperature-sensitive mutant at restrictive temperature.


ensembl_gene_id: YPL161C
symbol: BEM4
gene_biotype: protein_coding
description:
  Bud emergence protein 4; Protein involved in establishment of cell polarity and bud emergence; interacts with the Rho1p small GTP-binding protein and with the Rho-type GTPase Cdc42p; involved in maintenance of proper telomere length.


ensembl_gene_id: YPL162C
symbol: YPL162C
gene_biotype: protein_coding
description:
  Vacuolar membrane protein YPL162C; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of vacuole with cell cycle-correlated morphology.


ensembl_gene_id: YPL163C
symbol: SVS1
gene_biotype: protein_coding
description:
  Protein SVS1; Cell wall and vacuolar protein; required for wild-type resistance to vanadate; SVS1 has a paralog, SRL1, that arose from the whole genome duplication.


ensembl_gene_id: YPL164C
symbol: MLH3
gene_biotype: protein_coding
description:
  Protein involved in DNA mismatch repair and meiotic recombination; involved in crossing-over during meiotic recombination; forms a complex with Mlh1p; mammalian homolog is implicated mammalian microsatellite instability; Belongs to the DNA mismatch repair MutL/HexB family.


ensembl_gene_id: YPL165C
symbol: SET6
gene_biotype: protein_coding
description:
  Potential protein lysine methyltransferase SET6; SET domain protein of unknown function; deletion heterozygote is sensitive to compounds that target ergosterol biosynthesis, may be involved in compound availability.


ensembl_gene_id: YPL166W
symbol: ATG29
gene_biotype: protein_coding
description:
  Autophagy-related protein 29; Autophagy-specific protein; required for recruiting other ATG proteins to the pre-autophagosomal structure (PAS); interacts with Atg17p and localizas to the PAS in a manner interdependent with Atg17p and Cis1p; not conserved; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress; Belongs to the ATG29 family.


ensembl_gene_id: YPL167C
symbol: REV3
gene_biotype: protein_coding
description:
  Catalytic subunit of DNA polymerase zeta; involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair; forms a complex with Rev7p, Pol31p and Pol32p; Belongs to the DNA polymerase type-B family.


ensembl_gene_id: YPL168W
symbol: MRX4
gene_biotype: protein_coding
description:
  MIOREX complex component 4; Protein that associates with mitochondrial ribosome; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; expression may be cell cycle-regulated.


ensembl_gene_id: YPL169C
symbol: MEX67
gene_biotype: protein_coding
description:
  mRNA export factor MEX67; Poly(A)RNA binding protein involved in nuclear mRNA export; component of the nuclear pore; ortholog of human TAP; Belongs to the NXF family.


ensembl_gene_id: YPL170W
symbol: DAP1
gene_biotype: protein_coding
description:
  Damage response protein 1; Heme-binding protein; involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres, mitochondria, and sterol synthesis; Belongs to the cytochrome b5 family. MAPR subfamily.


ensembl_gene_id: YPL171C
symbol: OYE3
gene_biotype: protein_coding
description:
  NADPH dehydrogenase 3; Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); homologous to Oye2p with different ligand binding and catalytic properties; has potential roles in oxidative stress response and programmed cell death.


ensembl_gene_id: YPL172C
symbol: COX10
gene_biotype: protein_coding
description:
  Protoheme IX farnesyltransferase, mitochondrial; Heme A:farnesyltransferase; catalyzes first step in conversion of protoheme to heme A prosthetic group required for cytochrome c oxidase activity; human ortholog COX10 can complement yeast cox10 null mutant; human ortholog COX10 is associated with mitochondrial disorders; Belongs to the UbiA prenyltransferase family.


ensembl_gene_id: YPL174C
symbol: NIP100
gene_biotype: protein_coding
description:
  Protein NIP100; Large subunit of the dynactin complex; dynactin is involved in partitioning the mitotic spindle between mother and daughter cells; putative ortholog of mammalian p150(glued).


ensembl_gene_id: YPL175W
symbol: SPT14
gene_biotype: protein_coding
description:
  Phosphatidylinositol N-acetylglucosaminyltransferase GPI3 subunit; UDP-glycosyltransferase subunit of the GPI-GnT complex; UDP-GlcNAc-binding and catalytic subunit of the enzyme that mediates the first step in glycosylphosphatidylinositol (GPI) biosynthesis, mutations cause defects in transcription and in biogenesis of cell wall proteins.


ensembl_gene_id: YPL176C
symbol: TRE1
gene_biotype: protein_coding
description:
  Uncharacterized protein TRE1; Transferrin receptor-like protein; plasma membrane protein that binds Bsd2p and regulates ubiquitination and vacuolar degradation of the metal transporter Smf1p; functionally redundant with Tre2p; TRE1 has a paralog, TRE2, that arose from the whole genome duplication.


ensembl_gene_id: YPL177C
symbol: CUP9
gene_biotype: protein_coding
description:
  Homeobox protein CUP9; Homeodomain-containing transcriptional repressor; regulates expression of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription; CUP9 has a paralog, TOS8, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YPL178W
symbol: CBC2
gene_biotype: protein_coding
description:
  Nuclear cap-binding protein subunit 2; Small subunit of the heterodimeric cap binding complex with Sto1p; interacts with Npl3p, possibly to package mRNA for export from the nucleus; may have a role in telomere maintenance; contains an RNA-binding motif; Belongs to the RRM NCBP2 family.


ensembl_gene_id: YPL179W
symbol: PPQ1
gene_biotype: protein_coding
description:
  Serine/threonine-protein phosphatase PPQ; Protein phosphatase that regulates the mating response; negatively regulates the MAP kinase signaling cascade during mating; member of the serine/threonine phosphatase PP1 family; Belongs to the PPP phosphatase family. PP-Z subfamily.


ensembl_gene_id: YPL180W
symbol: TCO89
gene_biotype: protein_coding
description:
  Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p); regulates global H3K56ac; TORC1 complex regulates growth in response to nutrient availability; cooperates with Ssd1p in the maintenance of cellular integrity; deletion strains are hypersensitive to rapamycin.


ensembl_gene_id: YPL181W
symbol: CTI6
gene_biotype: protein_coding
description:
  Component of the Rpd3L histone deacetylase complex; relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain.


ensembl_gene_id: YPL182C
symbol: YPL182C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YPL182C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CTI6/YPL181W.


ensembl_gene_id: YPL183C
symbol: RTT10
gene_biotype: protein_coding
description:
  Regulator of Ty1 transposition protein 10; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rrt2p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; interacts with Trm7p for 2'-O-methylation of N34 of substrate tRNAs; has a role in regulation of Ty1 transposition; human ortholog is WDR6.


ensembl_gene_id: YPL183W-A
symbol: RTC6
gene_biotype: protein_coding
description:
  54S ribosomal protein RTC6, mitochondrial; Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress; Belongs to the bacterial ribosomal protein bL36 family.


ensembl_gene_id: YPL184C
symbol: MRN1
gene_biotype: protein_coding
description:
  RNA-binding protein that may be involved in translational regulation; binds specific categories of mRNAs, including those that contain upstream open reading frames (uORFs) and internal ribosome entry sites (IRES); interacts genetically with chromatin remodelers and splicing factors, linking chromatin state, splicing and as a result mRNA maturation.


ensembl_gene_id: YPL185W
symbol: YPL185W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YPL185W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene UIP4/YPL186C.


ensembl_gene_id: YPL186C
symbol: UIP4
gene_biotype: protein_coding
description:
  ULP1-interacting protein 4; Protein that interacts with Ulp1p; a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates; detected in a phosphorylated state in the mitochondrial outer membrane; also detected in ER and nuclear envelope.


ensembl_gene_id: YPL187W
symbol: MF(ALPHA)1
gene_biotype: protein_coding
description:
  Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)2, although MF(ALPHA)1 produces most alpha-factor; binds copper(II) ions.


ensembl_gene_id: YPL188W
symbol: POS5
gene_biotype: protein_coding
description:
  Mitochondrial NADH kinase; phosphorylates NADH; also phosphorylates NAD(+) with lower specificity; required for the response to oxidative stress.


ensembl_gene_id: YPL189C-A
symbol: COA2
gene_biotype: protein_coding
description:
  Cytochrome oxidase assembly factor; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity; functions downstream of assembly factors Mss51p and Coa1p and interacts with assembly factor Shy1p; Belongs to the COA2 family.


ensembl_gene_id: YPL189W
symbol: GUP2
gene_biotype: protein_coding
description:
  Glycerol uptake protein 2; Probable membrane protein; possible role in proton symport of glycerol; member of the MBOAT family of putative membrane-bound O-acyltransferases; homolog of the mammalian Hedgehog pathway modulator HHAT; GUP2 has a paralog, GUP1, that arose from the whole genome duplication.


ensembl_gene_id: YPL190C
symbol: NAB3
gene_biotype: protein_coding
description:
  RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex interacts with exosome to mediate 3'-end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; required for termination of non-poly(A) transcripts and efficient splicing; Nrd1-Nab3 pathway appears to have a role in rapid suppression of some genes when cells are shifted to poor growth conditions, indicating role for Nrd1-Nab3 in regulating cellular response to nutrient availability.


ensembl_gene_id: YPL191C
symbol: YPL191C
gene_biotype: protein_coding
description:
  Ubiquitin carboxyl-terminal hydrolase MIY1; Protein of unknown function; diploid deletion strain exhibits high budding index; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL191C has a paralog, YGL082W, that arose from the whole genome duplication; Belongs to the MINDY deubiquitinase family. FAM63 subfamily.


ensembl_gene_id: YPL192C
symbol: PRM3
gene_biotype: protein_coding
description:
  Pheromone-regulated membrane protein 3; Protein required for nuclear envelope fusion during karyogamy; pheromone-regulated; peripheral protein of the nuclear membrane; interacts with Kar5p at the spindle pole body.


ensembl_gene_id: YPL193W
symbol: RSA1
gene_biotype: protein_coding
description:
  Protein involved in the assembly of 60S ribosomal subunits; functionally interacts with Dbp6p; functions in a late nucleoplasmic step of the assembly.


ensembl_gene_id: YPL194W
symbol: DDC1
gene_biotype: protein_coding
description:
  DNA damage checkpoint protein; part of a PCNA-like complex required for DNA damage response, required for pachytene checkpoint to inhibit cell cycle in response to unrepaired recombination intermediates; potential Cdc28p substrate; forms nuclear foci upon DNA replication stress; Belongs to the DDC1 family.


ensembl_gene_id: YPL195W
symbol: APL5
gene_biotype: protein_coding
description:
  Delta adaptin-like subunit of the clathrin associated protein complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; suppressor of loss of casein kinase 1 function; the clathrin associated protein complex is also known as AP-3.


ensembl_gene_id: YPL196W
symbol: OXR1
gene_biotype: protein_coding
description:
  Oxidation resistance protein 1; Protein of unknown function required for oxidative damage resistance; required for normal levels of resistance to oxidative damage; null mutants are sensitive to hydrogen peroxide; member of a conserved family of proteins found in eukaryotes; Belongs to the OXR1 family.


ensembl_gene_id: YPL197C
symbol: YPL197C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YPL197C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the ribosomal gene RPL7B.


ensembl_gene_id: YPL198W
symbol: RPL7B
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L7B; required for processing of 27SA3 pre-rRNA to 27SB pre-rRNA during assembly of large ribosomal subunit; depletion leads to a turnover of pre-rRNA; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2); binds to Domain II of 25S and 5.8S rRNAs; homologous to mammalian ribosomal protein L7 and bacterial L30; RPL7B has a paralog, RPL7A, that arose from the whole genome duplication.


ensembl_gene_id: YPL199C
symbol: YPL199C
gene_biotype: protein_coding
description:
  Smr domain-containing protein YPL199C; Putative protein of unknown function; predicted to be palmitoylated.


ensembl_gene_id: YPL200W
symbol: CSM4
gene_biotype: protein_coding
description:
  Protein required for accurate chromosome segregation during meiosis; involved in meiotic telomere clustering (bouquet formation) and telomere-led rapid prophase movements; functions with meiosis-specific telomere-binding protein Ndj1p; CSM4 has a paralog, MPS2, that arose from the whole genome duplication.


ensembl_gene_id: YPL201C
symbol: YIG1
gene_biotype: protein_coding
description:
  Protein that interacts with glycerol 3-phosphatase; plays a role in anaerobic glycerol production; localizes to the nucleus and cytosol.


ensembl_gene_id: YPL202C
symbol: AFT2
gene_biotype: protein_coding
description:
  Iron-regulated transcriptional activator; activates genes involved in intracellular iron use and required for iron homeostasis and resistance to oxidative stress; AFT2 has a paralog, AFT1, that arose from the whole genome duplication.


ensembl_gene_id: YPL203W
symbol: TPK2
gene_biotype: protein_coding
description:
  cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk3p; localizes to P-bodies during stationary phase; relocalizes to the cytosol in response to hypoxia.


ensembl_gene_id: YPL204W
symbol: HRR25
gene_biotype: protein_coding
description:
  Conserved casein kinase; regulates diverse events including: vesicular traffic, DNA repair, the CVT pathway, monopolar attachment of sister kinetochores at meiosis I, and ribosomal subunit biogenesis; monopolin subunit; binds the RNAPII CTD; phosphorylates COPII coat subunits; interacts with Sit4p phosphatase; antagonizes calcineurin signaling, reducing nuclear accumulation of Crz1p; phosphorylates Dsn1p, the kinetochore receptor for monopolin; homolog of mammalian CK1delta.


ensembl_gene_id: YPL205C
symbol: YPL205C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YPL205C; Hypothetical protein; deletion of locus affects telomere length.


ensembl_gene_id: YPL206C
symbol: PGC1
gene_biotype: protein_coding
description:
  Phosphatidylglycerol phospholipase C; regulates phosphatidylglycerol (PG) accumulation via a phospholipase C-type degradation mechanism; PG levels affect mitochondrial function; contains glycerophosphodiester phosphodiesterase motifs; Belongs to the glycerophosphoryl diester phosphodiesterase family.


ensembl_gene_id: YPL207W
symbol: TYW1
gene_biotype: protein_coding
description:
  S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase; Iron-sulfer protein required for synthesis of Wybutosine modified tRNA; Wybutosine is a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions; induction by Yap5p in response to iron provides protection from high iron toxicity; overexpression results in increased cellular iron; Belongs to the TYW1 family.


ensembl_gene_id: YPL208W
symbol: RKM1
gene_biotype: protein_coding
description:
  SET-domain lysine-N-methyltransferase; catalyzes the formation of dimethyllysine residues on the large ribosomal subunit proteins L23 (Rpl23Ap and Rpl23Bp) and monomethyllysine residues on L18 (Rps18Ap and Rps18Bp).


ensembl_gene_id: YPL209C
symbol: IPL1
gene_biotype: protein_coding
description:
  Spindle assembly checkpoint kinase; Aurora kinase of chromosomal passenger complex; mediates release of mono-oriented kinetochores from microtubules in meiosis I, and kinetochore release from SPB clusters at meiotic exit; helps maintain condensed chromosomes during anaphase; required for SPB cohesion and prevention of multipolar spindle formation; promotes telomerase release at G2/M; Iocalizes to nuclear foci that diffuse upon DNA replication stress; required for inhibition of karyopherin Pse1p upon SAC arrest; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. A [...]


ensembl_gene_id: YPL210C
symbol: SRP72
gene_biotype: protein_coding
description:
  Core component of the signal recognition particle (SRP); the SRP is a ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane.


ensembl_gene_id: YPL211W
symbol: NIP7
gene_biotype: protein_coding
description:
  Nucleolar protein required for 60S ribosome subunit biogenesis; constituent of 66S pre-ribosomal particles; physically interacts with Nop8p and the exosome subunit Rrp43p.


ensembl_gene_id: YPL212C
symbol: PUS1
gene_biotype: protein_coding
description:
  tRNA:pseudouridine synthase; introduces pseudouridines at positions 26-28, 34-36, 65, and 67 of tRNA; also acts on U2 snRNA; also pseudouridylates some mRNAs, and pseudouridylation level varies with growth phase; nuclear protein that appears to be involved in tRNA export; PUS1 has a paralog, PUS2, that arose from the whole genome duplication.


ensembl_gene_id: YPL213W
symbol: LEA1
gene_biotype: protein_coding
description:
  U2 small nuclear ribonucleoprotein A; Component of U2 snRNP complex; disruption causes reduced U2 snRNP levels; physically interacts with Msl1p; putative homolog of human U2A' snRNP protein; Belongs to the U2 small nuclear ribonucleoprotein A family.


ensembl_gene_id: YPL214C
symbol: THI6
gene_biotype: protein_coding
description:
  Thiamine biosynthetic bifunctional enzyme; Thiamine-phosphate diphosphorylase and hydroxyethylthiazole kinase; required for thiamine biosynthesis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern.


ensembl_gene_id: YPL215W
symbol: CBP3
gene_biotype: protein_coding
description:
  Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex; Cbp3p-Cbp6p complex is sequestered if assembly of Complex III is blocked, downregulating COB mRNA translation.


ensembl_gene_id: YPL216W
symbol: YPL216W
gene_biotype: protein_coding
description:
  Putative ISWI chromatin-remodeling complex subunit YPL216W; Putative protein of unknown function; not an essential gene; YPL216W has a paralog, ITC1, that arose from the whole genome duplication.


ensembl_gene_id: YPL217C
symbol: BMS1
gene_biotype: protein_coding
description:
  Ribosome biogenesis protein BMS1; GTPase required for ribosomal subunit synthesis and rRNA processing; required for synthesis of 40S ribosomal subunits and for processing the 35S pre-rRNA at sites A0, A1, and A2; interacts with Rcl1p, which stimulates its GTPase and U3 snoRNA binding activities; has similarity to Tsr1p; Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. BMS1 subfamily.


ensembl_gene_id: YPL218W
symbol: SAR1
gene_biotype: protein_coding
description:
  ARF family GTPase; component of the COPII vesicle coat; required for transport vesicle formation during ER to Golgi protein transport; lowers membrane rigidity aiding vesicle formation; localizes to ER-mitochondrial contact sites where it enhances membrane curvature, thereby reducing contact size via its N-terminal amphipathic helix; regulates mitochondrial fission and fusion dynamics.


ensembl_gene_id: YPL219W
symbol: PCL8
gene_biotype: protein_coding
description:
  Cyclin; interacts with Pho85p cyclin-dependent kinase (Cdk) to phosphorylate and regulate glycogen synthase, also activates Pho85p for Glc8p phosphorylation; PCL8 has a paralog, PCL10, that arose from the whole genome duplication.


ensembl_gene_id: YPL220W
symbol: RPL1A
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L1A; N-terminally acetylated; homologous to mammalian ribosomal protein L10A and bacterial L1; RPL1A has a paralog, RPL1B, that arose from the whole genome duplication; rpl1a rpl1b double null mutation is lethal.


ensembl_gene_id: YPL221W
symbol: FLC1
gene_biotype: protein_coding
description:
  Flavin carrier protein 1; Flavin adenine dinucleotide transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; FLC1 has a paralog, FLC3, that arose from the whole genome duplication; Belongs to the transient receptor potential (TRP) ion channel family.


ensembl_gene_id: YPL222C-A
symbol: YPL222C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YPL222C-A; Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching.


ensembl_gene_id: YPL222W
symbol: FMP40
gene_biotype: protein_coding
description:
  Protein adenylyltransferase SelO, mitochondrial; Putative protein of unknown function; proposed to be involved in responding to environmental stresses; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies.


ensembl_gene_id: YPL223C
symbol: GRE1
gene_biotype: protein_coding
description:
  Protein GRE1; Hydrophilin essential in desiccation-rehydration process; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway; GRE1 has a paralog, SIP18, that arose from the whole genome duplication.


ensembl_gene_id: YPL224C
symbol: MMT2
gene_biotype: protein_coding
description:
  Putative metal transporter involved in mitochondrial iron accumulation; MMT2 has a paralog, MMT1, that arose from the whole genome duplication; Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.


ensembl_gene_id: YPL225W
symbol: YPL225W
gene_biotype: protein_coding
description:
  Protein PBDC1 homolog; Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress; Belongs to the PBDC1 family.


ensembl_gene_id: YPL226W
symbol: NEW1
gene_biotype: protein_coding
description:
  [NU+] prion formation protein 1; ATP binding cassette protein; cosediments with polysomes and is required for biogenesis of the small ribosomal subunit; Asn/Gln-rich rich region supports [NU+] prion formation and susceptibility to [PSI+] prion induction; Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.


ensembl_gene_id: YPL227C
symbol: ALG5
gene_biotype: protein_coding
description:
  UDP-glucose:dolichyl-phosphate glucosyltransferase; involved in asparagine-linked glycosylation in the endoplasmic reticulum; human ortholog ALG5 can partially complement yeast alg5 mutant; Belongs to the glycosyltransferase 2 family.


ensembl_gene_id: YPL228W
symbol: CET1
gene_biotype: protein_coding
description:
  mRNA-capping enzyme subunit beta; RNA 5'-triphosphatase involved in mRNA 5' capping; subunit of mRNA capping enzyme, which is a heterotetramer composed of a Cet1p homodimer and two molecules of guanylyltransferase Ceg1p; Cet1p also has a role in regulation of RNAPII pausing at promoter-proximal sites; interaction between Cet1p and Ceg1p is required for Ceg1p nuclear import; mammalian enzyme is single bifunctional polypeptide; human homolog RNGTT can complement yeast cet1 null mutant.


ensembl_gene_id: YPL229W
symbol: YPL229W
gene_biotype: protein_coding
description:
  Uncharacterized protein YPL229W; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; not an essential gene; YPL229W has a paralog, YMR181C, that arose from the whole genome duplication.


ensembl_gene_id: YPL230W
symbol: USV1
gene_biotype: protein_coding
description:
  Nutrient and stress factor 1; Putative transcription factor containing a C2H2 zinc finger; mutation affects transcriptional regulation of genes involved in growth on non-fermentable carbon sources, response to salt stress and cell wall biosynthesis; USV1 has a paralog, RGM1, that arose from the whole genome duplication.


ensembl_gene_id: YPL231W
symbol: FAS2
gene_biotype: protein_coding
description:
  3-oxoacyl-[acyl-carrier-protein] reductase; Alpha subunit of fatty acid synthetase; complex catalyzes the synthesis of long-chain saturated fatty acids; contains the acyl-carrier protein domain and beta-ketoacyl reductase, beta-ketoacyl synthase and self-pantetheinylation activities.


ensembl_gene_id: YPL232W
symbol: SSO1
gene_biotype: protein_coding
description:
  Protein SSO1; Plasma membrane t-SNARE; involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p; SSO1 has a paralog, SSO2, that arose from the whole genome duplication.


ensembl_gene_id: YPL233W
symbol: NSL1
gene_biotype: protein_coding
description:
  Kinetochore-associated protein NSL1; Essential component of the MIND kinetochore complex; joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation; complex consists of Mtw1p Including Nnf1p-Nsl1p-Dsn1p (MIND).


ensembl_gene_id: YPL234C
symbol: VMA11
gene_biotype: protein_coding
description:
  Vacuolar ATPase V0 domain subunit c'; involved in proton transport activity; hydrophobic integral membrane protein (proteolipid) containing four transmembrane segments; N and C termini are in the vacuolar lumen.


ensembl_gene_id: YPL235W
symbol: RVB2
gene_biotype: protein_coding
description:
  RuvB-like protein 2; ATP-dependent DNA helicase, also known as reptin; member of the AAA+ and RuvB protein families, similar to Rvb1p; conserved component of multiple complexes including the INO80 complex, the Swr1 complex, and the R2TP complex (Rvb1-Rvb2-Tah1-Pih1); involved in multiple processes such as chromatin remodeling, box C/D snoRNP assembly, and RNA polymerase II assembly.


ensembl_gene_id: YPL236C
symbol: ENV7
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase ENV7; Vacuolar membrane protein kinase; negatively regulates membrane fusion; associates with vacuolar membrane through palmitoylation of one or more cysteines in consensus sequence; vacuolar membrane association is essential to its kinase activity; mutant shows defect in CPY processing; ortholog of human serine/threonine kinase 16 (STK16).


ensembl_gene_id: YPL237W
symbol: SUI3
gene_biotype: protein_coding
description:
  Beta subunit of the translation initiation factor eIF2; involved in the identification of the start codon; proposed to be involved in mRNA binding.


ensembl_gene_id: YPL238C
symbol: YPL238C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YPL238C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified essential gene SUI3/YPL237W.


ensembl_gene_id: YPL239W
symbol: YAR1
gene_biotype: protein_coding
description:
  Ankyrin repeat-containing protein YAR1; Ankyrin-repeat containing, nucleocytoplasmic shuttling chaperone; prevents aggregation of Rps3p in the cytoplasm, associates with nascent Rps3p during its translation in the cytoplasm and delivers it to the 90S in the nucleus; required for 40S ribosomal subunit export, biogenesis and adaptation to osmotic and oxidative stress; expression repressed by heat shock.


ensembl_gene_id: YPL240C
symbol: HSP82
gene_biotype: protein_coding
description:
  ATP-dependent molecular chaperone HSP82; Hsp90 chaperone; redundant in function with Hsc82p; required for pheromone signaling, negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding, nucleotide addition; protein abundance increases in response to DNA replication stress; contains two acid-rich unstructured regions that promote solubility of chaperone-substrate complexes; HSP82 has a paralog, HSC82, that arose from the whole genome duplication.


ensembl_gene_id: YPL241C
symbol: CIN2
gene_biotype: protein_coding
description:
  Tubulin-specific chaperone C; GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; human homolog RP2 complements yeast null mutant.


ensembl_gene_id: YPL242C
symbol: IQG1
gene_biotype: protein_coding
description:
  Ras GTPase-activating-like protein IQG1; Essential protein required for determination of budding pattern; promotes localization of axial markers Bud4p and Cdc12p and functionally interacts with Sec3p, localizes to the contractile ring during anaphase, member of the IQGAP family; relocalizes from bud neck to cytoplasm upon DNA replication stress.


ensembl_gene_id: YPL243W
symbol: SRP68
gene_biotype: protein_coding
description:
  Core component of the signal recognition particle (SRP) complex; SRP complex functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress; Belongs to the SRP68 family.


ensembl_gene_id: YPL244C
symbol: HUT1
gene_biotype: protein_coding
description:
  UDP-galactose transporter homolog 1; Protein with a role in UDP-galactose transport to the Golgi lumen; has similarity to human UDP-galactose transporter UGTrel1, exhibits a genetic interaction with S. cerevisiae ERO1; Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.


ensembl_gene_id: YPL245W
symbol: YPL245W
gene_biotype: protein_coding
description:
  Uncharacterized protein YPL245W; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm.


ensembl_gene_id: YPL246C
symbol: RBD2
gene_biotype: protein_coding
description:
  Rhomboid protein 2; Possible rhomboid protease; has similarity to eukaryotic rhomboid proteases including Pcp1p.


ensembl_gene_id: YPL247C
symbol: YPL247C
gene_biotype: protein_coding
description:
  WD repeat-containing protein YPL247C; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; similar to the petunia WD repeat protein an11; overexpression causes a cell cycle delay or arrest.


ensembl_gene_id: YPL248C
symbol: GAL4
gene_biotype: protein_coding
description:
  Regulatory protein GAL4; DNA-binding transcription factor required for activating GAL genes; responds to galactose; repressed by Gal80p and activated by Gal3p.


ensembl_gene_id: YPL249C
symbol: GYP5
gene_biotype: protein_coding
description:
  GTPase-activating protein (GAP) for yeast Rab family members; involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; relocalizes from bud neck to cytoplasm upon DNA replication stress; GYP5 has a paralog, GYL1, that arose from the whole genome duplication.


ensembl_gene_id: YPL249C-A
symbol: RPL36B
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L36B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L36, no bacterial homolog; RPL36B has a paralog, RPL36A, that arose from the whole genome duplication.


ensembl_gene_id: YPL250C
symbol: ATG41
gene_biotype: protein_coding
description:
  Autophagy-related protein 41; Protein of unknown function; required for selective and nonselective autophagy, and mitophagy; regulates the rate of autophagosome formation; interacts with Atg9p, and has a similar peri-mitochondrial localization; elevated Gcn4p-dependent expression under autophagy-inducing conditions; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate; ATG41 has a paralog, ICY1, that arose from the whole genome duplication.


ensembl_gene_id: YPL250W-A
symbol: YPL250W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YPL250W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps the verified ORF RPL36B/YPL249C-A; identified by fungal homology and RT-PCR.


ensembl_gene_id: YPL251W
symbol: YPL251W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YPL251W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C.


ensembl_gene_id: YPL252C
symbol: YAH1
gene_biotype: protein_coding
description:
  Adrenodoxin homolog, mitochondrial; Ferredoxin of the mitochondrial matrix; required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; human homolog FDX1L can complement yeast by allowing growth during down-regulation of yeast YAH1; Belongs to the adrenodoxin/putidaredoxin family.


ensembl_gene_id: YPL253C
symbol: VIK1
gene_biotype: protein_coding
description:
  Spindle pole body-associated protein VIK1; Protein that forms a kinesin-14 heterodimeric motor with Kar3p; localizes Kar3p at mitotic spindle poles; has a structure similar to a kinesin motor domain but lacks an ATP-binding site and is catalytically inactive; binds microtubules; required for sister chromatid cohesion; VIK1 has a paralog, CIK1, that arose from the whole genome duplication.


ensembl_gene_id: YPL254W
symbol: HFI1
gene_biotype: protein_coding
description:
  Transcriptional coactivator HFI1/ADA1; Adaptor protein required for structural integrity of the SAGA complex; a histone acetyltransferase-coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functions.


ensembl_gene_id: YPL255W
symbol: BBP1
gene_biotype: protein_coding
description:
  Protein required for the spindle pole body (SPB) duplication; localizes at the cytoplasmic side of the central plaque periphery of the SPB; forms a complex with a nuclear envelope protein Mps2p and SPB components Spc29p and Kar1p; required for mitotic functions of Cdc5p; Belongs to the BBP1 family.


ensembl_gene_id: YPL256C
symbol: CLN2
gene_biotype: protein_coding
description:
  G1/S-specific cyclin CLN2; G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p); CLN2 has a paralog, CLN1, that arose from the whole genome duplication; cell cycle arrest phenotype of the cln1 cln2 cln3 triple null mutant is complemented by any of human cyclins CCNA2, CCNB1, CCNC, CCND1, or CCNE1.


ensembl_gene_id: YPL257W
symbol: YPL257W
gene_biotype: protein_coding
description:
  Uncharacterized membrane protein YPL257W; Putative protein of unknown function; homozygous diploid deletion strain exhibits low budding index; physically interacts with Hsp82p; YPL257W is not an essential gene.


ensembl_gene_id: YPL258C
symbol: THI21
gene_biotype: protein_coding
description:
  Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI21; Hydroxymethylpyrimidine (HMP) and HMP-phosphate kinase; involved in thiamine biosynthesis; member of a gene family with THI20 and THI22; functionally redundant with Thi20p; In the C-terminal section; belongs to the thiaminase-2 family.


ensembl_gene_id: YPL259C
symbol: APM1
gene_biotype: protein_coding
description:
  Mu1-like medium subunit of the AP-1 complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; the AP-1 complex is the clathrin-associated protein complex.


ensembl_gene_id: YPL260W
symbol: CUB1
gene_biotype: protein_coding
description:
  UPF0662 protein YPL260W; Conserved fungal gene linked to DNA repair and proteasome function; putative substrate of cAMP-dependent protein kinase (PKA); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YPL260W is not an essential gene; protein abundance increases in response to DNA replication stress; Belongs to the UPF0662 family.


ensembl_gene_id: YPL261C
symbol: YPL261C
gene_biotype: protein_coding
description:
  Uncharacterized protein YPL261C; Putative protein of unknown function; conserved among S. cerevisiae strains; YPL261C is not an essential gene; partially overlaps verified ORF YPL260W.


ensembl_gene_id: YPL262W
symbol: FUM1
gene_biotype: protein_coding
description:
  Fumarate hydratase, mitochondrial; Fumarase; converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.


ensembl_gene_id: YPL264C
symbol: YPL264C
gene_biotype: protein_coding
description:
  Probable transport protein YPL264C; Putative membrane protein of unknown function; physically interacts with Hsp82p; YPL264C is not an essential gene.


ensembl_gene_id: YPL265W
symbol: DIP5
gene_biotype: protein_coding
description:
  Dicarboxylic amino acid permease; mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate; also a transporter for Gln, Asn, Ser, Ala, and Gly; relocalizes from plasma membrane to vacuole upon DNA replication stress.


ensembl_gene_id: YPL266W
symbol: DIM1
gene_biotype: protein_coding
description:
  Essential 18S rRNA dimethylase (dimethyladenosine transferase); responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing; human homolog DIMT1 complements yeast dim1 mutant.


ensembl_gene_id: YPL267W
symbol: ACM1
gene_biotype: protein_coding
description:
  APC/C-CDH1 modulator 1; Pseudosubstrate inhibitor of the APC/C; suppresses APC/C [Cdh1]-mediated proteolysis of mitotic cyclins; associates with Cdh1p, Bmh1p and Bmh2p; cell cycle regulated protein; the anaphase-promoting complex/cyclosome is also known as APC/C.


ensembl_gene_id: YPL268W
symbol: PLC1
gene_biotype: protein_coding
description:
  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1; Phospholipase C; hydrolyzes phosphatidylinositol 4,5-biphosphate (PIP2) to generate the signaling molecules inositol 1,4,5-triphosphate (IP3) and 1,2-diacylglycerol (DAG); involved in regulating many cellular processes; Plc1p and inositol polyphosphates are required for acetyl-CoA homeostasis which regulates global histone acetylation.


ensembl_gene_id: YPL269W
symbol: KAR9
gene_biotype: protein_coding
description:
  Karyogamy protein KAR9; Spindle positioning factor; orients astral microtubules, connecting them to actin cables at the cortex with Bim1p and Myo2, resulting in proper spindle positioning; targeted for StuBL-dependent degradation at kinetochores by Slx5p-Slx8p, ensuring chromosome transmission fidelity and correct spindle positioning; role in karyogamy; localizes to the shmoo tip, the growing bud-tip, the nucleus, the kinetochore, the spindle and microtubules; homolog of adenomatous polyposis coli.


ensembl_gene_id: YPL270W
symbol: MDL2
gene_biotype: protein_coding
description:
  ATP-dependent permease MDL2, mitochondrial; Mitochondrial inner membrane half-type ABC transporter; required for respiratory growth at high temperature; localizes to vacuole membrane in response to H2O2; similar to human TAP1 and TAP2 implicated in bare lymphocyte syndrome and Wegener-like granulomatosis; Belongs to the ABC transporter superfamily. ABCB family. Mitochondrial peptide exporter (TC 3.A.1.212) subfamily.


ensembl_gene_id: YPL271W
symbol: ATP15
gene_biotype: protein_coding
description:
  Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase; which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; F1 translationally regulates ATP6 and ATP8 expression to achieve a balanced output of ATP synthase genes encoded in nucleus and mitochondria; phosphorylated; Belongs to the eukaryotic ATPase epsilon family.


ensembl_gene_id: YPL272C
symbol: PBI1
gene_biotype: protein_coding
description:
  Uncharacterized protein YPL272C; Putative protein of unknown function; gene expression induced in response to ketoconazole; YPL272C is not an essential gene.


ensembl_gene_id: YPL273W
symbol: SAM4
gene_biotype: protein_coding
description:
  Homocysteine S-methyltransferase 2; S-adenosylmethionine-homocysteine methyltransferase; functions along with Mht1p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio; SAM4 has a paralog, YMR321C, that arose from a single-locus duplication.


ensembl_gene_id: YPL274W
symbol: SAM3
gene_biotype: protein_coding
description:
  High-affinity S-adenosylmethionine permease; required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p.


ensembl_gene_id: YPL277C
symbol: YPL277C
gene_biotype: protein_coding
description:
  Uncharacterized protein YPL277C; Putative protein of unknown function; localized to the membranes; gene expression regulated by copper levels.


ensembl_gene_id: YPL279C
symbol: FEX2
gene_biotype: protein_coding
description:
  Protein involved in fluoride export; nearly identical to FEX1, and deletion of both proteins results in a large increase in fluoride sensitivity compared with the single mutant; contains two FEX domains connected by a linker; part of a widespread family of conserved fluoride export proteins; Belongs to the fluoride exporter Fluc/FEX family.


ensembl_gene_id: YPL280W
symbol: HSP32
gene_biotype: protein_coding
description:
  Probable glutathione-independent glyoxalase HSP32; Possible chaperone and cysteine protease; required for transcriptional reprogramming during the diauxic shift and for survival in stationary phase; similar to E. coli Hsp31 and S. cerevisiae Hsp31p, Hsp33p, and Sno4p; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease and cancer; Belongs to the peptidase C56 family. HSP31-like subfamily.


ensembl_gene_id: YPL281C
symbol: ERR2
gene_biotype: protein_coding
description:
  Enolase, a phosphopyruvate hydratase; catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate; complements the growth defect of an ENO1 ENO2 double mutant.


ensembl_gene_id: YPL282C
symbol: PAU22
gene_biotype: protein_coding
description:
  Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions; SWAT-GFP fusion protein localizes to the endoplasmic reticulum and vacuole, while mCherry fusion localizes to just the vacuole; identical to Pau21p; encodes two proteins that are translated from two different start codons.


ensembl_gene_id: YPR001W
symbol: CIT3
gene_biotype: protein_coding
description:
  Dual specificity mitochondrial citrate and methylcitrate synthase; catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate and that of propionyl-CoA and oxaloacetate to form 2-methylcitrate.


ensembl_gene_id: YPR002C-A
symbol: YPR002C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YPR002C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the Ty1 long terminal repeat, YPRWdelta12.


ensembl_gene_id: YPR002W
symbol: PDH1
gene_biotype: protein_coding
description:
  Putative 2-methylcitrate dehydratase; mitochondrial protein that participates in respiration; induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate.


ensembl_gene_id: YPR003C
symbol: YPR003C
gene_biotype: protein_coding
description:
  Putative sulfate permease; physically interacts with Hsp82p; green fluorescent protein (GFP)-fusion protein localizes to the ER; YPR003C is not an essential gene; Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.


ensembl_gene_id: YPR004C
symbol: AIM45
gene_biotype: protein_coding
description:
  Probable electron transfer flavoprotein subunit alpha, mitochondrial; Putative ortholog of mammalian ETF-alpha; interacts with frataxin, Yfh1p; null mutant displays elevated frequency of mitochondrial genome loss; may have a role in oxidative stress response; ETF-alpha is an electron transfer flavoprotein complex subunit.


ensembl_gene_id: YPR005C
symbol: HAL1
gene_biotype: protein_coding
description:
  Cytoplasmic protein involved in halotolerance; decreases intracellular Na+ (via Ena1p) and increases intracellular K+ by decreasing efflux; expression repressed by Ssn6p-Tup1p and Sko1p and induced by NaCl, KCl, and sorbitol through Gcn4p.


ensembl_gene_id: YPR006C
symbol: ICL2
gene_biotype: protein_coding
description:
  2-methylisocitrate lyase of the mitochondrial matrix; functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol.


ensembl_gene_id: YPR007C
symbol: REC8
gene_biotype: protein_coding
description:
  Meiotic recombination protein REC8; Meiosis-specific component of the sister chromatid cohesion complex; alpha-kleisin family member that maintains cohesion between sister chromatids during meiosis I; maintains cohesion between centromeres of sister chromatids until meiosis II; independent of its role in sister chromatid cohesion, Rec8p promotes allelic collisions and prevents nonspecific chromosome interactions; homolog of S. pombe Rec8p.


ensembl_gene_id: YPR008W
symbol: HAA1
gene_biotype: protein_coding
description:
  Transcriptional activator involved in adaptation to weak acid stress; activates transcription of TPO2, YRO2, and other genes encoding membrane stress proteins; HAA1 has a paralog, CUP2, that arose from the whole genome duplication; relocalizes from cytoplasm to nucleus upon DNA replication stress.


ensembl_gene_id: YPR009W
symbol: SUT2
gene_biotype: protein_coding
description:
  Sterol uptake protein 2; Zn2Cys6 family transcription factor; positively regulates sterol uptake under anaerobic conditions with SUT1; represses filamentation-inducing genes during non-starvation conditions; positively regulates mating along with SUT1 by repressing the expression of genes (PRR2, NCE102 and RHO5) which function as mating inhibitors; multicopy suppressor of mutations that cause low activity of the cAMP/PKA pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication.


ensembl_gene_id: YPR010C-A
symbol: YPR010C-A
gene_biotype: protein_coding
description:
  UPF0495 protein YPR010C-A; Putative protein of unknown function; SWAT-GFP, seamless-GFP and mCherry fusion proteins localize to the cytosol; conserved among Saccharomyces sensu stricto species.


ensembl_gene_id: YPR011C
symbol: YPR011C
gene_biotype: protein_coding
description:
  Uncharacterized mitochondrial carrier YPR011C; Mitochondrial transporter; major substrates are adenosine 5'-phosphosulfate (APS) and 3'-phospho-adenosine 5'-phosphosulfate (PAPS); member of the mitochondrial carrier family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies.


ensembl_gene_id: YPR012W
symbol: YPR012W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YPR012W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; YPR012W is not an essential gene.


ensembl_gene_id: YPR014C
symbol: YPR014C
gene_biotype: protein_coding
description:
  Uncharacterized protein YPR014C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; YPR014C is not an essential gene.


ensembl_gene_id: YPR015C
symbol: YPR015C
gene_biotype: protein_coding
description:
  Putative zinc finger transcription factor; binds DNA in sequence-specific manner; overexpression causes a cell cycle delay or arrest.


ensembl_gene_id: YPR016C
symbol: TIF6
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 6; Constituent of 66S pre-ribosomal particles; has similarity to human translation initiation factor 6 (eIF6); may be involved in the biogenesis and or stability of 60S ribosomal subunits; Belongs to the eIF-6 family.


ensembl_gene_id: YPR016W-A
symbol: YPR016W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YPR016W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YPR017C
symbol: DSS4
gene_biotype: protein_coding
description:
  Protein DSS4; Guanine nucleotide dissociation stimulator for Sec4p; functions in the post-Golgi secretory pathway; binds zinc, found both on membranes and in the cytosol; Belongs to the DSS4/MSS4 family.


ensembl_gene_id: YPR018W
symbol: RLF2
gene_biotype: protein_coding
description:
  Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1); chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkpoint after DNA repair; chromatin dynamics during transcription; and repression of divergent noncoding transcription.


ensembl_gene_id: YPR019W
symbol: MCM4
gene_biotype: protein_coding
description:
  DNA replication licensing factor MCM4; Essential helicase component of heterohexameric MCM2-7 complexes; MCM2-7 complexes bind pre-replication complexes on DNA and melt DNA prior to replication; forms an Mcm4p-6p-7p subcomplex; shows nuclear accumulation in G1; homolog of S. pombe Cdc21p.


ensembl_gene_id: YPR020W
symbol: ATP20
gene_biotype: protein_coding
description:
  Subunit g of the mitochondrial F1F0 ATP synthase; reversibly phosphorylated on two residues; unphosphorylated form is required for dimerization of the ATP synthase complex, which in turn determines oligomerization of the complex and the shape of inner membrane cristae.


ensembl_gene_id: YPR021C
symbol: AGC1
gene_biotype: protein_coding
description:
  Mitochondrial amino acid transporter; acts both as a glutamate uniporter and as an aspartate-glutamate exchanger; involved in nitrogen metabolism and nitrogen compound biosynthesis; human homolog SLC25A13 complements yeast null mutant; Belongs to the mitochondrial carrier (TC 2.A.29) family.


ensembl_gene_id: YPR022C
symbol: SDD4
gene_biotype: protein_coding
description:
  Zinc finger protein YPR022C; Putative transcription factor, as suggested by computational analysis; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS; overproduction of a truncation allele suppresses lethality due to expression of the dominant PET9 allele AAC2-A128P.


ensembl_gene_id: YPR023C
symbol: EAF3
gene_biotype: protein_coding
description:
  Chromatin modification-related protein EAF3; Component of the Rpd3S histone deacetylase complex; Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3; plays a role in regulating Ty1 transposition.


ensembl_gene_id: YPR024W
symbol: YME1
gene_biotype: protein_coding
description:
  Catalytic subunit of i-AAA protease complex; complex is located in mitochondrial inner membrane; responsible for degradation of unfolded or misfolded mitochondrial gene products; serves as nonconventional translocation motor to pull PNPase into intermembrane space; also has role in intermembrane space protein folding; mutation causes elevated rate of mitochondrial turnover; human homolog YME1L1 can complement yeast null mutant; In the C-terminal section; belongs to the peptidase M41 family.


ensembl_gene_id: YPR025C
symbol: CCL1
gene_biotype: protein_coding
description:
  Cyclin associated with protein kinase Kin28p; Kin28p is the TFIIH-associated carboxy-terminal domain (CTD) kinase involved in transcription initiation at RNA polymerase II promoters; human homolog CCNH allows growth of yeast ccl1 temperature-sensitive mutant at restrictive temperature.


ensembl_gene_id: YPR026W
symbol: ATH1
gene_biotype: protein_coding
description:
  Acid trehalase required for utilization of extracellular trehalose; involved in intracellular trehalose degradation during growth recovery after saline stress.


ensembl_gene_id: YPR027C
symbol: YPR027C
gene_biotype: protein_coding
description:
  Uncharacterized membrane protein YPR027C; Putative protein of unknown function; SWAT-GFP and seamless-GFP fusion proteins localize to the endoplasmic reticulum, while the mCherry fusion protein localizes to the vacuole.


ensembl_gene_id: YPR028W
symbol: YOP1
gene_biotype: protein_coding
description:
  Protein YOP1; Reticulon-interacting protein; ER integral membrane protein involved in the generation of tubular ER morphology; promotes membrane curvature; forms tubules in vitro; regulates the ER asymmetry-induced inheritance block during ER stress; role in ER-derived peroxisomal biogenesis; interacts with Yip1p to mediate membrane traffic and with Sey1p to maintain ER morphology; facilitates lipid exchange between the ER and mitochondria; forms ER foci upon DNA replication stress.


ensembl_gene_id: YPR029C
symbol: APL4
gene_biotype: protein_coding
description:
  AP-1 complex subunit gamma-1; Gamma-adaptin; large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport.


ensembl_gene_id: YPR030W
symbol: CSR2
gene_biotype: protein_coding
description:
  Transcription factor CSR2; Nuclear ubiquitin protein ligase binding protein; may regulate utilization of nonfermentable carbon sources and endocytosis of plasma membrane proteins; overproduction suppresses chs5 spa2 lethality at high temp; ubiquitinated by Rsp5p, deubiquitinated by Ubp2p; CSR2 has a paralog, ECM21, that arose from the whole genome duplication.


ensembl_gene_id: YPR031W
symbol: NTO1
gene_biotype: protein_coding
description:
  NuA3 HAT complex component NTO1; Subunit of the NuA3 histone acetyltransferase complex; this complex acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3.


ensembl_gene_id: YPR032W
symbol: SRO7
gene_biotype: protein_coding
description:
  Lethal(2) giant larvae protein homolog SRO7; Effector of Rab GTPase Sec4p; forms a complex with Sec4p and t-SNARE Sec9p; involved in exocytosis and docking and fusion of post-Golgi vesicles with plasma membrane; regulates cell proliferation and colony development via the Rho1-Tor1 pathway; homolog of Drosophila lgl tumor suppressor; SRO7 has a paralog, SRO77, that arose from the whole genome duplication; Belongs to the WD repeat L(2)GL family.


ensembl_gene_id: YPR033C
symbol: HTS1
gene_biotype: protein_coding
description:
  Histidine--tRNA ligase, mitochondrial; Cytoplasmic and mitochondrial histidine tRNA synthetase; efficient mitochondrial localization requires both a presequence and an amino-terminal sequence; mutations in human ortholog HARS2 are associated with Perrault syndrome; Belongs to the class-II aminoacyl-tRNA synthetase family.


ensembl_gene_id: YPR034W
symbol: ARP7
gene_biotype: protein_coding
description:
  Actin-related protein 7; Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation.


ensembl_gene_id: YPR035W
symbol: GLN1
gene_biotype: protein_coding
description:
  Glutamine synthetase (GS); synthesizes glutamine from glutamate and ammonia; with Glt1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source and by amino acid limitation; forms filaments of back-to-back stacks of cylindrical homo-decamers at low pH, leading to enzymatic inactivation and storage during states of advanced cellular starvation; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress.


ensembl_gene_id: YPR036W
symbol: VMA13
gene_biotype: protein_coding
description:
  Subunit H of the V1 peripheral membrane domain of V-ATPase; part of the electrogenic proton pump found throughout the endomembrane system; serves as an activator or a structural stabilizer of the V-ATPase; the V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase) has eight subunits.


ensembl_gene_id: YPR036W-A
symbol: SPO24
gene_biotype: protein_coding
description:
  Sporulation protein 24; Small (67 amino acids) protein involved in sporulation; localizes to the prospore membrane; phosphorylated during meiosis; a longer, 5'-extended mRNA is also transcribed beginning in mid-meiosis, regulated by two MSEs (middle sporulation elements), and includes an uORF of 15 codons in its 5'-UTR; evidence transcription is regulated by Pdr1p.


ensembl_gene_id: YPR037C
symbol: ERV2
gene_biotype: protein_coding
description:
  Flavin-linked sulfhydryl oxidase localized to the ER lumen; involved in disulfide bond formation within the endoplasmic reticulum (ER).


ensembl_gene_id: YPR038W
symbol: IRC16
gene_biotype: protein_coding
description:
  Putative increased recombination centers protein 16; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified gene YPR037C; null mutant displays increased levels of spontaneous Rad52p foci.


ensembl_gene_id: YPR039W
symbol: YPR039W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YPR039W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified non essential genes ERV2/YPR037C and TIP41/YPR040W.


ensembl_gene_id: YPR040W
symbol: TIP41
gene_biotype: protein_coding
description:
  Type 2A phosphatase activator TIP41; Protein that interacts with Tap42p, which regulates PP2A; component of the TOR (target of rapamycin) signaling pathway; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YPR041W
symbol: TIF5
gene_biotype: protein_coding
description:
  Translation initiation factor eIF5; functions both as a GTPase-activating protein to mediate hydrolysis of ribosome-bound GTP and as a GDP dissociation inhibitor to prevent recycling of eIF2; Belongs to the eIF-2-beta/eIF-5 family.


ensembl_gene_id: YPR042C
symbol: PUF2
gene_biotype: protein_coding
description:
  PUF family mRNA-binding protein; Pumilio homology domain confers RNA binding activity; preferentially binds mRNAs encoding membrane-associated proteins; binding site composed of two UAAU tetranucleotides, separated by a 3-nt linker; PUF2 has a paralog, JSN1, that arose from the whole genome duplication.


ensembl_gene_id: YPR043W
symbol: RPL43A
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L43A; null mutation confers a dominant lethal phenotype; homologous to mammalian ribosomal protein L37A, no bacterial homolog; RPL43A has a paralog, RPL43B, that arose from the whole genome duplication.


ensembl_gene_id: YPR044C
symbol: OPI11
gene_biotype: protein_coding
description:
  Putative uncharacterized protein OPI11; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; largely overlaps verified gene RPL43A/YPR043W; deletion confers sensitivity to GSAO.


ensembl_gene_id: YPR045C
symbol: THP3
gene_biotype: protein_coding
description:
  Protein that may have a role in transcription elongation; forms a complex with Csn12p that is recruited to transcribed genes; possibly involved in splicing based on pre-mRNA accumulation defect for many intron-containing genes.


ensembl_gene_id: YPR046W
symbol: MCM16
gene_biotype: protein_coding
description:
  Inner kinetochore subunit MCM16; Component of the Ctf19 complex and the COMA subcomplex; involved in kinetochore-microtubule mediated chromosome segregation; binds to centromere DNA; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-H and fission yeast fta3.


ensembl_gene_id: YPR047W
symbol: MSF1
gene_biotype: protein_coding
description:
  Phenylalanine--tRNA ligase, mitochondrial; Mitochondrial phenylalanyl-tRNA synthetase; active as a monomer, unlike the cytoplasmic subunit which is active as a dimer complexed to a beta subunit dimer; similar to the alpha subunit of E. coli phenylalanyl-tRNA synthetase.


ensembl_gene_id: YPR048W
symbol: TAH18
gene_biotype: protein_coding
description:
  NADPH-dependent diflavin oxidoreductase 1; Conserved NAPDH-dependent diflavin reductase; component of an early step in the cytosolic Fe-S protein assembly (CIA) machinery; transfers electrons from NADPH to the Fe-S cluster of Dre2p; plays a pro-death role under oxidative stress; Tah18p-dependent nitric oxide synthesis confers high-temperature stress tolerance; possible target for development of antifungal drugs; In the N-terminal section; belongs to the flavodoxin family.


ensembl_gene_id: YPR049C
symbol: ATG11
gene_biotype: protein_coding
description:
  Autophagy-related protein 11; Adapter protein for pexophagy and the Cvt targeting pathway; directs receptor-bound cargo to the phagophore assembly site (PAS) for packaging into vesicles; required for recruiting other proteins to the PAS; recruits Dnm1p to facilitate fission of mitochondria that are destined for removal by mitophagy; Belongs to the ATG11 family.


ensembl_gene_id: YPR050C
symbol: YPR050C
gene_biotype: protein_coding
description:
  Putative uncharacterized membrane protein YPR050C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps verified ORF MAK3/YPR051W.


ensembl_gene_id: YPR051W
symbol: MAK3
gene_biotype: protein_coding
description:
  N-alpha-acetyltransferase 30; Catalytic subunit of the NatC type N-terminal acetyltransferase (NAT); involved in subcellular targeting of select N-terminally acetylated substrates to the Golgi apparatus (Arl3p and Grh1p) and the inner nuclear membrane (Trm1p); required for replication of dsRNA virus; human NatC ortholog, Naa60, functionally complements the null, requiring either auxiliary subunit Mak10p or co-expression of human ortholog, Naa35; Naa60, the human NatF gene, also complements the null allele; Belongs to the acetyltransferase family. MAK3 subfamily.


ensembl_gene_id: YPR052C
symbol: NHP6A
gene_biotype: protein_coding
description:
  Non-histone chromosomal protein 6A; High-mobility group (HMG) protein; binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to chromosomes; functionally redundant with Nhp6Bp; required for transcriptional initiation fidelity of some tRNA genes; homologous to mammalian HMGB1 and HMGB2; NHP6A has a paralog, NHP6B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YPR053C
symbol: YPR053C
gene_biotype: protein_coding
description:
  Uncharacterized protein YPR053C; Putative protein of unknown function; conserved among S. cerevisiae strains; YPR053C is not an essential gene; partially overlaps verified ORF NHP6A/YPR052C.


ensembl_gene_id: YPR054W
symbol: SMK1
gene_biotype: protein_coding
description:
  Middle sporulation-specific mitogen-activated protein kinase (MAPK); required for production of the outer spore wall layers; negatively regulates activity of the glucan synthase subunit Gsc2p.


ensembl_gene_id: YPR055W
symbol: SEC8
gene_biotype: protein_coding
description:
  Essential 121 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; involved in ER and Golgi inheritance in small buds; relocalizes away from bud neck upon DNA replication stress; Belongs to the SEC8 family.


ensembl_gene_id: YPR056W
symbol: TFB4
gene_biotype: protein_coding
description:
  General transcription and DNA repair factor IIH subunit TFB4; Subunit of TFIIH complex; involved in transcription initiation, similar to 34 kDa subunit of human TFIIH; interacts with Ssl1p.


ensembl_gene_id: YPR057W
symbol: BRR1
gene_biotype: protein_coding
description:
  Pre-mRNA-splicing factor BRR1; snRNP protein component of spliceosomal snRNPs; required for pre-mRNA splicing and snRNP biogenesis; in null mutant newly-synthesized snRNAs are destabilized and 3'-end processing is slowed; Belongs to the BRR1 family.


ensembl_gene_id: YPR058W
symbol: YMC1
gene_biotype: protein_coding
description:
  Secondary mitochondrial inner membrane glycine transporter; required with HEM25 for the transport of glycine into mitochondria for the initiation of heme biosynthesis; proposed role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; localizes to the vacuole in response to H2O2; YMC1 has a paralog, YMC2, that arose from the whole genome duplication.


ensembl_gene_id: YPR059C
symbol: YPR059C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YPR059C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YMC1/YPR058W.


ensembl_gene_id: YPR060C
symbol: ARO7
gene_biotype: protein_coding
description:
  Chorismate mutase; catalyzes the conversion of chorismate to prephenate to initiate the tyrosine/phenylalanine-specific branch of aromatic amino acid biosynthesis.


ensembl_gene_id: YPR061C
symbol: JID1
gene_biotype: protein_coding
description:
  J domain-containing protein 1; Probable Hsp40p co-chaperone; has a DnaJ-like domain and appears to be involved in ER-associated degradation of misfolded proteins containing a tightly folded cytoplasmic domain; inhibits replication of Brome mosaic virus in S. cerevisiae.


ensembl_gene_id: YPR062W
symbol: FCY1
gene_biotype: protein_coding
description:
  Cytosine deaminase; zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU); Belongs to the cytidine and deoxycytidylate deaminase family.


ensembl_gene_id: YPR064W
symbol: YPR064W
gene_biotype: protein_coding
description:
  Uncharacterized protein YPR064W; Putative protein of unknown function; conserved among S. cerevisiae strains; YPR064W is not an essential gene.


ensembl_gene_id: YPR065W
symbol: ROX1
gene_biotype: protein_coding
description:
  Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance.


ensembl_gene_id: YPR066W
symbol: UBA3
gene_biotype: protein_coding
description:
  NEDD8-activating enzyme E1 catalytic subunit; Protein that activates Rub1p (NEDD8) before neddylation; acts together with Ula1p; may play a role in protein degradation; GFP-fusion protein localizes to the cytoplasm in a punctate pattern.


ensembl_gene_id: YPR067W
symbol: ISA2
gene_biotype: protein_coding
description:
  Iron-sulfur assembly protein 2; Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa1p and possibly Iba57p; localizes to the mitochondrial intermembrane space, overexpression of ISA2 suppresses grx5 mutations.


ensembl_gene_id: YPR068C
symbol: HOS1
gene_biotype: protein_coding
description:
  Class I histone deacetylase (HDAC) family member; deacetylates Smc3p on lysine residues at anaphase onset; has sequence similarity to Hda1p, Rpd3p, Hos2p, and Hos3p; interacts with the Tup1p-Ssn6p corepressor complex.


ensembl_gene_id: YPR069C
symbol: SPE3
gene_biotype: protein_coding
description:
  Spermidine synthase; involved in biosynthesis of spermidine and also in biosynthesis of pantothenic acid; spermidine is required for growth of wild-type cells.


ensembl_gene_id: YPR071W
symbol: YPR071W
gene_biotype: protein_coding
description:
  Putative membrane protein; YPR071W is not an essential gene; YPR071W has a paralog, YIL029C, that arose from a single-locus duplication.


ensembl_gene_id: YPR072W
symbol: NOT5
gene_biotype: protein_coding
description:
  General negative regulator of transcription subunit 5; Component of the CCR4-NOT core complex, involved in mRNA decapping; involved intranscription initiation and elongation and in mRNA degradation; conserved lysine in human homolog of Not5p and Not3p is mutated in cancers.


ensembl_gene_id: YPR074C
symbol: TKL1
gene_biotype: protein_coding
description:
  Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; TKL1 has a paralog, TKL2, that arose from the whole genome duplication.


ensembl_gene_id: YPR075C
symbol: OPY2
gene_biotype: protein_coding
description:
  Protein OPY2; Integral membrane protein that acts as a membrane anchor for Ste50p; involved in the signaling branch of the high-osmolarity glycerol (HOG) pathway and as a regulator of the filamentous growth pathway; overproduction blocks cell cycle arrest in the presence of mating pheromone; relocalizes from vacuole to plasma membrane upon DNA replication stress.


ensembl_gene_id: YPR076W
symbol: YPR076W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YPR076W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YPR077C
symbol: YPR077C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YPR077C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression increased by deletion of NAP1.


ensembl_gene_id: YPR078C
symbol: YPR078C
gene_biotype: protein_coding
description:
  Uncharacterized protein YPR078C; Putative protein of unknown function; possible role in DNA metabolism and/or in genome stability; expression is heat-inducible.


ensembl_gene_id: YPR079W
symbol: MRL1
gene_biotype: protein_coding
description:
  Membrane protein; has similarity to mammalian mannose-6-phosphate receptors; possibly functions as a sorting receptor in the delivery of vacuolar hydrolases; protein abundance increases in response to DNA replication stress; Belongs to the MRL1/IGF2R family.


ensembl_gene_id: YPR080W
symbol: TEF1
gene_biotype: protein_coding
description:
  Translational elongation factor EF-1 alpha; in the GTP-bound active form, binds to and delivers aminoacylated tRNA to the A-site of ribosomes for elongation of nascent polypeptides; associates with vacuolar Rho1p GTPase; may also have a role in tRNA re-export from the nucleus; TEF1 has a paralog, TEF2, that arose from the whole genome duplication.


ensembl_gene_id: YPR081C
symbol: GRS2
gene_biotype: protein_coding
description:
  Glycine--tRNA ligase 2; Glycine-tRNA synthetase, not expressed under normal growth conditions; expression is induced under heat, oxidative, pH, or ethanol stress conditions; more stable than the major glycine-tRNA synthetase Grs1p at 37 deg C; GRS2 has a paralog, GRS1, that arose from the whole genome duplication.


ensembl_gene_id: YPR082C
symbol: DIB1
gene_biotype: protein_coding
description:
  Spliceosomal protein DIB1; 17-kDa component of the U4/U6aU5 tri-snRNP; plays an essential role in pre-mRNA splicing; human ortholog TXNL4A (the human U5-specific 15-kDa protein) complements yeast dib1 null mutant; Belongs to the DIM1 family.


ensembl_gene_id: YPR083W
symbol: MDM36
gene_biotype: protein_coding
description:
  Mitochondrial protein; required for normal mitochondrial morphology and inheritance; component of the mitochondria-ER-cortex-ancor (MECA); interacts with Num1p to link the ER and mitochondria at the cell cortex; proposed involvement in the formation of Dnm1p and Num1p-containing cortical anchor complexes that promote mitochondrial fission.


ensembl_gene_id: YPR085C
symbol: ASA1
gene_biotype: protein_coding
description:
  ASTRA-associated protein 1; Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1.


ensembl_gene_id: YPR086W
symbol: SUA7
gene_biotype: protein_coding
description:
  Transcription factor TFIIB; a general transcription factor required for transcription initiation and start site selection by RNA polymerase II.


ensembl_gene_id: YPR087W
symbol: VPS69
gene_biotype: protein_coding
description:
  Putative uncharacterized protein VPS69; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the verified gene SRP54; deletion causes a vacuolar protein sorting defect.


ensembl_gene_id: YPR088C
symbol: SRP54
gene_biotype: protein_coding
description:
  Signal recognition particle (SRP) subunit (homolog of mammalian SRP54); contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal receptor; contains GTPase domain.


ensembl_gene_id: YPR089W
symbol: YPR089W
gene_biotype: protein_coding
description:
  Dilute domain-containing protein YPR089W; Protein of unknown function; exhibits genetic interaction with ERG11 and protein-protein interaction with Hsp82p.


ensembl_gene_id: YPR091C
symbol: NVJ2
gene_biotype: protein_coding
description:
  Uncharacterized PH domain-containing protein YPR091C; Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial-lipid binding protein (SMP) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes, based on co-purification experiments.


ensembl_gene_id: YPR092W
symbol: YPR092W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YPR092W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YPR093C
symbol: ASR1
gene_biotype: protein_coding
description:
  Alcohol-sensitive RING finger protein 1; Ubiquitin ligase that modifies and regulates RNA Pol II; involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; has a role in organization of septins and the actin cytoskeleton; contains a Ring/PHD finger domain similar to the mammalian rA9 protein.


ensembl_gene_id: YPR094W
symbol: RDS3
gene_biotype: protein_coding
description:
  Pre-mRNA-splicing factor RDS3; Component of the SF3b subcomplex of the U2 snRNP; zinc cluster protein involved in pre-mRNA splicing and cycloheximide resistance.


ensembl_gene_id: YPR095C
symbol: SYT1
gene_biotype: protein_coding
description:
  Guanine nucleotide exchange factor (GEF) for Arf proteins; promotes activation of Arl1p, which recruits Imh1p to the Golgi; involved in vesicular transport; member of the Sec7-domain family; contains a PH domain.


ensembl_gene_id: YPR096C
symbol: YPR096C
gene_biotype: protein_coding
description:
  Uncharacterized protein YPR096C; Protein of unknown function; may interact with ribosomes, based on co-purification experiments.


ensembl_gene_id: YPR097W
symbol: YPR097W
gene_biotype: protein_coding
description:
  Protein that contains a PX domain and binds phosphoinositides; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; PX stands for Phox homology.


ensembl_gene_id: YPR099C
symbol: YPR099C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YPR099C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MRPL51/YPR100W.


ensembl_gene_id: YPR101W
symbol: SNT309
gene_biotype: protein_coding
description:
  Pre-mRNA-splicing factor SNT309; Member of the NineTeen Complex (NTC); this complex contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; interacts physically and genetically with Prp19p.


ensembl_gene_id: YPR102C
symbol: RPL11A
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L11A; expressed at twice the level of Rpl11Bp; involved in ribosomal assembly; depletion causes degradation of 60S proteins and RNA; homologous to mammalian ribosomal protein L11 and bacterial L5; RPL11A has a paralog, RPL11B, that arose from the whole genome duplication.


ensembl_gene_id: YPR103W
symbol: PRE2
gene_biotype: protein_coding
description:
  Beta 5 subunit of the 20S proteasome; responsible for the chymotryptic activity of the proteasome; Belongs to the peptidase T1B family.


ensembl_gene_id: YPR104C
symbol: FHL1
gene_biotype: protein_coding
description:
  Pre-rRNA-processing protein FHL1; Regulator of ribosomal protein (RP) transcription; has forkhead associated domain that binds phosphorylated proteins; recruits coactivator Ifh1p or corepressor Crf1p to RP gene promoters; also has forkhead DNA-binding domain though in vitro DNA binding assays give inconsistent results; computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p motifs at others; suppresses RNA pol III and splicing factor prp4 mutants.


ensembl_gene_id: YPR106W
symbol: ISR1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase ISR1; Predicted protein kinase; overexpression causes sensitivity to staurosporine, which is a potent inhibitor of protein kinase C.


ensembl_gene_id: YPR107C
symbol: YTH1
gene_biotype: protein_coding
description:
  mRNA 3'-end-processing protein YTH1; Essential RNA-binding component of cleavage and polyadenylation factor; contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation; relocalizes to the cytosol in response to hypoxia.


ensembl_gene_id: YPR108W
symbol: RPN7
gene_biotype: protein_coding
description:
  Essential non-ATPase regulatory subunit of the 26S proteasome; similar to another S. cerevisiae regulatory subunit, Rpn5p, as well as to mammalian proteasome subunits.


ensembl_gene_id: YPR108W-A
symbol: YPR108W-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YPR108W-A; Putative protein of unknown function; identified by fungal homology and RT-PCR.


ensembl_gene_id: YPR109W
symbol: YPR109W
gene_biotype: protein_coding
description:
  Golgi/endosome-localized DSC protein 1; Predicted membrane protein; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum; diploid deletion strain has high budding index.


ensembl_gene_id: YPR110C
symbol: RPC40
gene_biotype: protein_coding
description:
  RNA polymerase subunit AC40; common to RNA polymerase I and III; predominant determinant targeting Ty1 integration upstream of Pol III-transcribed genes.


ensembl_gene_id: YPR111W
symbol: DBF20
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase DBF20; Ser/Thr kinase involved in late nuclear division; one of the mitotic exit network (MEN) proteins; necessary for the execution of cytokinesis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs; DBF20 has a paralog, DBF2, that arose from the whole genome duplication.


ensembl_gene_id: YPR112C
symbol: MRD1
gene_biotype: protein_coding
description:
  Multiple RNA-binding domain-containing protein 1; Essential conserved small ribosomal subunit (40s) synthesis factor; component of the 90S preribosome; required for production of 18S rRNA and small ribosomal subunit; contains five consensus RNA-binding domains and binds to the pre-rRNA at two sites within the 18S region.


ensembl_gene_id: YPR113W
symbol: PIS1
gene_biotype: protein_coding
description:
  CDP-diacylglycerol--inositol 3-phosphatidyltransferase; Phosphatidylinositol synthase; required for biosynthesis of phosphatidylinositol, which is a precursor for polyphosphoinositides, sphingolipids, and glycolipid anchors for some of the plasma membrane proteins; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.


ensembl_gene_id: YPR115W
symbol: RGC1
gene_biotype: protein_coding
description:
  Putative regulator of the Fps1p glycerol channel; multiply phosphorylated by Hog1p under osmotic stress; contains a pleckstrin homology domain; forms homodimers and heterodimerizes with paralog Ask10p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; Belongs to the RGC1 family.


ensembl_gene_id: YPR116W
symbol: RRG8
gene_biotype: protein_coding
description:
  Protein of unknown function; required for mitochondrial genome maintenance; null mutation results in a decrease in plasma membrane electron transport; Belongs to the RRG8 family.


ensembl_gene_id: YPR118W
symbol: MRI1
gene_biotype: protein_coding
description:
  5'-methylthioribose-1-phosphate isomerase; catalyzes the isomerization of 5-methylthioribose-1-phosphate to 5-methylthioribulose-1-phosphate in the methionine salvage pathway; Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.


ensembl_gene_id: YPR119W
symbol: CLB2
gene_biotype: protein_coding
description:
  G2/mitotic-specific cyclin-2; B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome; CLB2 has a paralog, CLB1, that arose from the whole genome duplication.


ensembl_gene_id: YPR120C
symbol: CLB5
gene_biotype: protein_coding
description:
  S-phase entry cyclin-5; B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase; CLB5 has a paralog, CLB6, that arose from the whole genome duplication.


ensembl_gene_id: YPR121W
symbol: THI22
gene_biotype: protein_coding
description:
  Thiamine biosynthesis protein THI22; Protein with similarity to hydroxymethylpyrimidine phosphate kinases; member of a gene family with THI20 and THI21; not required for thiamine biosynthesis; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively.


ensembl_gene_id: YPR122W
symbol: AXL1
gene_biotype: protein_coding
description:
  Putative protease AXL1; Haploid specific endoprotease of a-factor mating pheromone; performs one of two N-terminal cleavages during maturation of a-factor mating pheromone; required for axial budding pattern of haploid cells.


ensembl_gene_id: YPR123C
symbol: YPR123C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YPR123C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF CTR.


ensembl_gene_id: YPR124W
symbol: CTR1
gene_biotype: protein_coding
description:
  High-affinity copper transporter of plasma membrane; mediates nearly all copper uptake under low copper conditions; transcriptionally induced at low copper levels and degraded at high copper levels; protein increases in abundance and relocalizes from nucleus to plasma membrane upon DNA replication stress; human homolog SLC31A1 can complement a yeast ctr1 ctr3 double deletion.


ensembl_gene_id: YPR125W
symbol: YLH47
gene_biotype: protein_coding
description:
  LETM1 domain-containing protein YLH47, mitochondrial; Mitochondrial inner membrane protein; exposed to the mitochondrial matrix; associates with mitochondrial ribosomes; NOT required for respiratory growth; homolog of human Letm1, a protein implicated in Wolf-Hirschhorn syndrome.


ensembl_gene_id: YPR126C
symbol: YPR126C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YPR126C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YPR127W
symbol: YPR127W
gene_biotype: protein_coding
description:
  Putative pyridoxal reductase; Putative pyridoxine 4-dehydrogenase; differentially expressed during alcoholic fermentation; expression activated by transcription factor YRM1/YOR172W; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus.


ensembl_gene_id: YPR128C
symbol: ANT1
gene_biotype: protein_coding
description:
  Peroxisomal adenine nucleotide transporter; involved in beta-oxidation of medium-chain fatty acid; required for peroxisome proliferation; Belongs to the mitochondrial carrier (TC 2.A.29) family.


ensembl_gene_id: YPR129W
symbol: SCD6
gene_biotype: protein_coding
description:
  Protein SCD6; Repressor of translation initiation; binds eIF4G through its RGG domain and inhibits recruitment of the preinitiation complex; also contains an Lsm domain; may have a role in RNA processing; overproduction suppresses null mutation in clathrin heavy chain gene CHC1; forms cytoplasmic foci upon DNA replication stress.


ensembl_gene_id: YPR130C
symbol: YPR130C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YPR130C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YPR131C
symbol: NAT3
gene_biotype: protein_coding
description:
  Catalytic subunit of the NatB N-terminal acetyltransferase; NatB catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met; Belongs to the acetyltransferase family. GNAT subfamily.


ensembl_gene_id: YPR132W
symbol: RPS23B
gene_biotype: protein_coding
description:
  Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit; required for translational accuracy; homologous to mammalian ribosomal protein S23 and bacterial S12; RPS23B has a paralog, RPS23A, that arose from the whole genome duplication; deletion of both RPS23A and RPS23B is lethal.


ensembl_gene_id: YPR133C
symbol: SPN1
gene_biotype: protein_coding
description:
  Transcription factor SPN1; Protein involved in RNA polymerase II transcription; is constitutively recruited to the CYC1 promoter and is required for recruitment of chromatin remodeling factors for the expression of CYC1 gene; interacts genetically or physically with RNAP II, TBP, TFIIS, and chromatin remodelling factors; central domain highly conserved throughout eukaryotes; mutations confer an Spt- phenotype.


ensembl_gene_id: YPR133W-A
symbol: TOM5
gene_biotype: protein_coding
description:
  Mitochondrial import receptor subunit TOM5; Component of the TOM (translocase of outer membrane) complex; responsible for recognition and initial import of all mitochondrially directed proteins; involved in transfer of precursors from the Tom70p and Tom20p receptors to the Tom40p pore; Belongs to the Tom5 family.


ensembl_gene_id: YPR134W
symbol: MSS18
gene_biotype: protein_coding
description:
  Nuclear encoded protein needed for splicing of mitochondrial intron; required for efficient splicing of mitochondrial COX1 aI5beta intron; mss18 mutations block cleavage of 5' exon - intron junction; phenotype of intronless strain suggests additional functions.


ensembl_gene_id: YPR135W
symbol: CTF4
gene_biotype: protein_coding
description:
  DNA polymerase alpha-binding protein; Chromatin-associated protein; required for sister chromatid cohesion; interacts with DNA polymerase alpha (Pol1p) and may link DNA synthesis to sister chromatid cohesion.


ensembl_gene_id: YPR136C
symbol: YPR136C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YPR136C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified ORF RRP9.


ensembl_gene_id: YPR137W
symbol: RRP9
gene_biotype: protein_coding
description:
  Ribosomal RNA-processing protein 9; Protein involved in pre-rRNA processing; associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein; Belongs to the WD repeat RRP9 family.


ensembl_gene_id: YPR138C
symbol: MEP3
gene_biotype: protein_coding
description:
  Ammonium transporter MEP3; Ammonium permease of high capacity and low affinity; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation ammonia permease; MEP3 has a paralog, MEP1, that arose from the whole genome duplication; Belongs to the ammonia transporter channel (TC 1.A.11.2) family.


ensembl_gene_id: YPR139C
symbol: LOA1
gene_biotype: protein_coding
description:
  Lysophosphatidic acid acyltransferase; involved in triacelglyceride homeostasis and lipid droplet formation; localized to lipid droplets and the ER; specificity for oleoyl-CoA.


ensembl_gene_id: YPR140W
symbol: TAZ1
gene_biotype: protein_coding
description:
  Lyso-phosphatidylcholine acyltransferase; required for normal phospholipid content of mitochondrial membranes; major determinant of the final acyl chain composition of the mitochondrial-specific phospholipid cardiolipin; mutations in human ortholog tafazzin (TAZ) cause Barth syndrome, a rare X-linked disease characterized by skeletal and cardiomyopathy and bouts of cyclic neutropenia; a specific splice variant of human TAZ can complement yeast null mutant.


ensembl_gene_id: YPR141C
symbol: KAR3
gene_biotype: protein_coding
description:
  Kinesin-like protein KAR3; Minus-end-directed microtubule motor; functions in mitosis and meiosis, localizes to the spindle pole body and localization is dependent on functional Cik1p, required for nuclear fusion during mating; potential Cdc28p substrate.


ensembl_gene_id: YPR142C
symbol: YPR142C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YPR142C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RRP15, which is required for ribosomal RNA processing.


ensembl_gene_id: YPR143W
symbol: RRP15
gene_biotype: protein_coding
description:
  Nucleolar protein; constituent of pre-60S ribosomal particles; required for proper processing of the 27S pre-rRNA at the A3 and B1 sites to yield mature 5.8S and 25S rRNAs; Belongs to the RRP15 family.


ensembl_gene_id: YPR144C
symbol: NOC4
gene_biotype: protein_coding
description:
  Nucleolar protein; forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits; relocalizes to the cytosol in response to hypoxia.


ensembl_gene_id: YPR145W
symbol: ASN1
gene_biotype: protein_coding
description:
  Asparagine synthetase; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway; ASN1 has a paralog, ASN2, that arose from the whole genome duplication.


ensembl_gene_id: YPR146C
symbol: YPR146C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YPR146C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YPR147C
symbol: YPR147C
gene_biotype: protein_coding
description:
  Uncharacterized protein YPR147C; Protein of unknown function; may have a role in lipid metabolism, based on localization to lipid droplets; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS.


ensembl_gene_id: YPR148C
symbol: YPR148C
gene_biotype: protein_coding
description:
  Uncharacterized protein YPR148C; Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern.


ensembl_gene_id: YPR149W
symbol: NCE102
gene_biotype: protein_coding
description:
  Non-classical export protein 2; Protein of unknown function; contains transmembrane domains; involved in secretion of proteins that lack classical secretory signal sequences; component of the detergent-insoluble glycolipid-enriched complexes (DIGs); NCE102 has a paralog, FHN1, that arose from the whole genome duplication.


ensembl_gene_id: YPR150W
symbol: YPR150W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YPR150W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SUE1/YPR151C.


ensembl_gene_id: YPR151C
symbol: SUE1
gene_biotype: protein_coding
description:
  Protein SUE1, mitochondrial; Protein required for degradation of unstable forms of cytochrome c; located in the mitochondria.


ensembl_gene_id: YPR152C
symbol: URN1
gene_biotype: protein_coding
description:
  Pre-mRNA-splicing factor URN1; Protein of unknown function containing WW and FF domains; overexpression causes accumulation of cells in G1 phase.


ensembl_gene_id: YPR154W
symbol: PIN3
gene_biotype: protein_coding
description:
  [PSI+] inducibility protein 3; Negative regulator of actin nucleation-promoting factor activity; interacts with Las17p, a homolog of human Wiskott-Aldrich Syndrome protein (WASP), via an N-terminal SH3 domain, and along with LSB1 cooperatively inhibits the nucleation of actin filaments; short-lived protein whose levels increase in response to thermal stress; induces the formation of the [PIN+] and [RNQ+] prions when overproduced; PIN3 has a paralog, LSB1, that arose from the whole genome duplication.


ensembl_gene_id: YPR155C
symbol: NCA2
gene_biotype: protein_coding
description:
  Nuclear control of ATPase protein 2; Protein that regulates expression of Fo-F1 ATP synthase subunits; involved in the regulation of mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; functions with Nca3p.


ensembl_gene_id: YPR156C
symbol: TPO3
gene_biotype: protein_coding
description:
  Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to the plasma membrane; TPO3 has a paralog, TPO2, that arose from the whole genome duplication.


ensembl_gene_id: YPR157W
symbol: TDA6
gene_biotype: protein_coding
description:
  Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; null mutant is sensitive to expression of the top1-T722A allele; SWAT-GFP and mCherry fusion proteins localize to the cell periphery and vacuole; TDA6 has a paralog, VPS62, that arose from the whole genome duplication.


ensembl_gene_id: YPR158W
symbol: CUR1
gene_biotype: protein_coding
description:
  Curing of [URE3] protein 1; Sorting factor, central regulator of spatial protein quality control; physically and functionally interacts with chaperones to promote sorting and deposition of misfolded proteins into cytosolic compartments; involved in destabilization of [URE3] prions; CUR1 has a paralog, BTN2, that arose from the whole genome duplication.


ensembl_gene_id: YPR159C-A
symbol: YPR159C-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YPR159C-A; Protein of unknown function; SWAT-GFP and mCherry fusion proteins localize to the cytosol; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching.


ensembl_gene_id: YPR159W
symbol: KRE6
gene_biotype: protein_coding
description:
  Beta-glucan synthesis-associated protein KRE6; Type II integral membrane protein; required for beta-1,6 glucan biosynthesis; putative beta-glucan synthase; localizes to ER, plasma membrane, sites of polarized growth and secretory vesicles; functionally redundant with Skn1p; KRE6 has a paralog, SKN1, that arose from the whole genome duplication; Belongs to the SKN1/KRE6 family.


ensembl_gene_id: YPR160C-A
symbol: YPR160C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YPR160C-A; Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching.


ensembl_gene_id: YPR160W
symbol: GPH1
gene_biotype: protein_coding
description:
  Glycogen phosphorylase required for the mobilization of glycogen; non-essential; regulated by cyclic AMP-mediated phosphorylation; phosphorylation by Cdc28p may coordinately regulate carbohydrate metabolism and the cell cycle; expression is regulated by stress-response elements and by the HOG MAP kinase pathway.


ensembl_gene_id: YPR160W-A
symbol: YPR160W-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YPR160W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by expression profiling and mass spectrometry.


ensembl_gene_id: YPR161C
symbol: SGV1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase BUR1; Cyclin (Bur2p)-dependent protein kinase; part of the BUR kinase complex which functions in transcriptional regulation; phosphorylates the carboxy-terminal domain (CTD) of Rpo21p and the C-terminal repeat domain of Spt5p; recruits Spt6p to the CTD at the onset of transcription; regulated by Cak1p; similar to metazoan CDK9 proteins; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.


ensembl_gene_id: YPR162C
symbol: ORC4
gene_biotype: protein_coding
description:
  Subunit of the origin recognition complex (ORC); ORC directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; ORC4 has a paralog, RIF2, that arose from the whole genome duplication.


ensembl_gene_id: YPR163C
symbol: TIF3
gene_biotype: protein_coding
description:
  Translation initiation factor eIF-4B; contains an RNA recognition motif and binds to single-stranded RNA; has RNA annealing activity; interacts with Rps20p at the head of the 40S ribosomal subunit and alters the structure of the mRNA entry channel.


ensembl_gene_id: YPR164W
symbol: MMS1
gene_biotype: protein_coding
description:
  Subunit of E3 ubiquitin ligase complex involved in replication repair; stabilizes protein components of the replication fork such as the fork-pausing complex and leading strand polymerase, preventing fork collapse and promoting efficient recovery during replication stress; regulates Ty1 transposition; involved with Rtt101p in nonfunctional rRNA decay.


ensembl_gene_id: YPR165W
symbol: RHO1
gene_biotype: protein_coding
description:
  GTP-binding protein of the rho subfamily of Ras-like proteins; involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p).


ensembl_gene_id: YPR167C
symbol: MET16
gene_biotype: protein_coding
description:
  Phosphoadenosine phosphosulfate reductase; 3'-phosphoadenylsulfate reductase; reduces 3'-phosphoadenylyl sulfate to adenosine-3',5'-bisphosphate and free sulfite using reduced thioredoxin as cosubstrate, involved in sulfate assimilation and methionine metabolism; Belongs to the PAPS reductase family. CysH subfamily.


ensembl_gene_id: YPR168W
symbol: NUT2
gene_biotype: protein_coding
description:
  Subunit of the RNA polymerase II mediator complex; conserved from yeast to human; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for transcriptional activation and has a role in basal transcription; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YPR169W
symbol: JIP5
gene_biotype: protein_coding
description:
  WD repeat-containing protein JIP5; Protein required for biogenesis of the large ribosomal subunit; required for biogenesis of the large ribosomal subunit; interacts with proteins involved in RNA processing, ribosome biogenesis, ubiquitination and demethylation; similar to WDR55, a human WD repeat protein; essential gene.


ensembl_gene_id: YPR169W-A
symbol: YPR169W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YPR169W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps two other dubious ORFs: YPR170C and YPR170W-B.


ensembl_gene_id: YPR170C
symbol: YPR170C
gene_biotype: protein_coding
description:
  Putative uncharacterized membrane protein YPR170C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps ORFs YPR169W-A and YPR170W-B.


ensembl_gene_id: YPR170W-A
symbol: YPR170W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YPR170W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by expression profiling and mass spectrometry.


ensembl_gene_id: YPR170W-B
symbol: YPR170W-B
gene_biotype: protein_coding
description:
  Uncharacterized protein YPR170W-B; Putative protein of unknown function; conserved in fungi; SWAT-GFP fusion protein localizes to the vacuole membrane; partially overlaps the dubious genes YPR169W-A, YPR170W-A and YRP170C.


ensembl_gene_id: YPR171W
symbol: BSP1
gene_biotype: protein_coding
description:
  Protein BSP1; Adapter that links synaptojanins to the cortical actin cytoskeleton; the synaptojanins are Inp52p and Inp53p.


ensembl_gene_id: YPR172W
symbol: YPR172W
gene_biotype: protein_coding
description:
  Pyridoxamine 5'-phosphate oxidase homolog; Protein of unknown function; predicted to encode a pyridoxal 5'-phosphate synthase based on sequence similarity but purified protein does not possess this activity, nor does it bind flavin mononucleotide (FMN); transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; YPR172W has a paralog, YLR456W, that arose from the whole genome duplication.


ensembl_gene_id: YPR173C
symbol: VPS4
gene_biotype: protein_coding
description:
  AAA-ATPase involved in multivesicular body (MVB) protein sorting; ATP-bound Vps4p localizes to endosomes and catalyzes ESCRT-III disassembly and membrane release; ATPase activity is activated by Vta1p; regulates cellular sterol metabolism.


ensembl_gene_id: YPR174C
symbol: YPR174C
gene_biotype: protein_coding
description:
  Nuclear envelope protein YPR174C; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery; potential Cdc28p substrate; binds phosphatidylinositols and phosphatidylethanolamine in a large-scale study; relative distribution to foci at the nuclear periphery increases upon DNA replication stress; YPR174C has a paralog, NBP1, that arose from the whole genome duplication.


ensembl_gene_id: YPR175W
symbol: DPB2
gene_biotype: protein_coding
description:
  Second largest subunit of DNA polymerase II (DNA polymerase epsilon); required for maintenance of fidelity of chromosomal replication; essential motif in C-terminus is required for formation of the four-subunit Pol epsilon; expression peaks at the G1/S phase boundary; Cdc28p substrate.


ensembl_gene_id: YPR176C
symbol: BET2
gene_biotype: protein_coding
description:
  Beta subunit of Type II geranylgeranyltransferase; required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p; human homolog RABGGTB can complement yeast BET2 mutant.


ensembl_gene_id: YPR177C
symbol: YPR177C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YPR177C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the 5' end of the essential PRP4 gene encoding a component of the U4/U6-U5 snRNP complex.


ensembl_gene_id: YPR178W
symbol: PRP4
gene_biotype: protein_coding
description:
  U4/U6 small nuclear ribonucleoprotein PRP4; Splicing factor; component of the U4/U6-U5 snRNP complex.


ensembl_gene_id: YPR179C
symbol: HDA3
gene_biotype: protein_coding
description:
  Subunit of the HDA1 histone deacetylase complex; possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex contains Hda1p homodimer and an Hda2p-Hda3p heterodimer; required for the activity of the complex; relocalizes to the cytosol in response to hypoxia; similar to Hda2p.


ensembl_gene_id: YPR180W
symbol: AOS1
gene_biotype: protein_coding
description:
  DNA damage tolerance protein RHC31; Subunit of heterodimeric nuclear SUMO activating enzyme E1 with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability; relocalizes to the cytosol in response to hypoxia.


ensembl_gene_id: YPR181C
symbol: SEC23
gene_biotype: protein_coding
description:
  GTPase-activating protein, stimulates the GTPase activity of Sar1p; component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, involved in ER to Golgi transport; substrate of Ubp3/Bre5 complex; ubiquitylated by Ub-ligase Rsp5p; proteasome-mediated degradation of Sec23p is regulated by Cdc48p.


ensembl_gene_id: YPR182W
symbol: SMX3
gene_biotype: protein_coding
description:
  Small nuclear ribonucleoprotein F; Core Sm protein Sm F; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm F.


ensembl_gene_id: YPR183W
symbol: DPM1
gene_biotype: protein_coding
description:
  Dolichol-phosphate mannosyltransferase; Dolichol phosphate mannose (Dol-P-Man) synthase of ER membrane; catalyzes formation of Dol-P-Man from Dol-P and GDP-Man; required for biosynthesis of glycosyl phosphatidylinositol (GPI) membrane anchor, as well as O-mannosylation and protein N- and O-linked glycosylation; human homolog DPM1 can complement yeast mutant strains.


ensembl_gene_id: YPR184W
symbol: GDB1
gene_biotype: protein_coding
description:
  Amylo-alpha-1,6-glucosidase; Glycogen debranching enzyme; contains glucanotranferase and alpha-1,6-amyloglucosidase activities; required for glycogen degradation; phosphorylated in mitochondria; activity is inhibited by Igd1p; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YPR185W
symbol: ATG13
gene_biotype: protein_coding
description:
  Autophagy-related protein 13; Regulatory subunit of the Atg1p signaling complex; stimulates Atg1p kinase activity; required for vesicle formation during autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; contains a HORMA domain required for autophagy and for recruitment of the phosphatidylinositol 3-kinase complex subunit Atg14p to the pre-autophagosomal structure; Belongs to the ATG13 family. Fungi subfamily.


ensembl_gene_id: YPR186C
symbol: PZF1
gene_biotype: protein_coding
description:
  Transcription factor IIIA (TFIIIA); essential DNA binding protein required for transcription of 5S rRNA by RNA polymerase III; not involved in transcription of other RNAP III genes; nine conserved zinc fingers; may also bind 5S rRNA.


ensembl_gene_id: YPR187W
symbol: RPO26
gene_biotype: protein_coding
description:
  RNA polymerase subunit ABC23; common to RNA polymerases I, II, and III; part of central core; similar to bacterial omega subunit; Belongs to the archaeal RpoK/eukaryotic RPB6 RNA polymerase subunit family.


ensembl_gene_id: YPR188C
symbol: MLC2
gene_biotype: protein_coding
description:
  Regulatory light chain for the type II myosin Myo1p; binds to an IQ motif of Myo1p, localization to the bud neck depends on Myo1p; involved in the disassembly of the Myo1p ring.


ensembl_gene_id: YPR189W
symbol: SKI3
gene_biotype: protein_coding
description:
  Superkiller protein 3; Ski complex component and TPR protein; mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay; mutations in the human ortholog, TTC37, causes Syndromic diarrhea/Trichohepatoenteric (SD/THE) syndrome.


ensembl_gene_id: YPR191W
symbol: QCR2
gene_biotype: protein_coding
description:
  Subunit 2 of ubiquinol cytochrome-c reductase (Complex III); Complex III is a component of the mitochondrial inner membrane electron transport chain; phosphorylated; transcription is regulated by Hap1p, Hap2p/Hap3p, and heme.


ensembl_gene_id: YPR192W
symbol: AQY1
gene_biotype: protein_coding
description:
  Aquaporin-1; Spore-specific water channel; mediates the transport of water across cell membranes, developmentally controlled; may play a role in spore maturation, probably by allowing water outflow, may be involved in freeze tolerance.


ensembl_gene_id: YPR193C
symbol: HPA2
gene_biotype: protein_coding
description:
  Tetrameric histone acetyltransferase; has similarity to Gcn5p, Hat1p, Elp3p, and Hpa3p; acetylates histones H3 and H4 in vitro and exhibits autoacetylation activity; also acetylates polyamines.


ensembl_gene_id: YPR194C
symbol: OPT2
gene_biotype: protein_coding
description:
  Oligopeptide transporter; localized to peroxisomes and affects glutathione redox homeostasis; also localizes to the plasma membrane (PM) and to the late Golgi, and has a role in maintenance of lipid asymmetry between the inner and outer leaflets of the PM; member of the OPT family, with potential orthologs in S. pombe and C. albicans; also plays a role in formation of mature vacuoles and in polarized cell growth.


ensembl_gene_id: YPR195C
symbol: YPR195C
gene_biotype: protein_coding
description:
  Uncharacterized protein YPR195C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YPR196W
symbol: YPR196W
gene_biotype: protein_coding
description:
  Maltose fermentation regulatory protein YPR196W; Putative maltose-responsive transcription factor; Belongs to the MAL13 family.


ensembl_gene_id: YPR197C
symbol: YPR197C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YPR197C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF SGE1/YPR198W.


ensembl_gene_id: YPR198W
symbol: SGE1
gene_biotype: protein_coding
description:
  Protein SGE1; Plasma membrane multidrug transporter; member of the major facilitator superfamily; acts as an extrusion permease; partial multicopy suppressor of gal11 mutations.


ensembl_gene_id: YPR199C
symbol: ARR1
gene_biotype: protein_coding
description:
  AP-1-like transcription factor YAP8; Transcriptional activator of the basic leucine zipper (bZIP) family; required for transcription of genes involved in resistance to arsenic compounds; directly binds trivalent arsenic (As(III)) as does K. lactis ortholog, KIYAP8.


ensembl_gene_id: YPR200C
symbol: ARR2
gene_biotype: protein_coding
description:
  Arsenical-resistance protein 2; Arsenate reductase required for arsenate resistance; converts arsenate to arsenite which can then be exported from cells by Arr3p.


ensembl_gene_id: YPR201W
symbol: ARR3
gene_biotype: protein_coding
description:
  Arsenical-resistance protein 3; Plasma membrane metalloid/H+ antiporter; member of bile/arsenite/riboflavin transporter (BART) superfamily; transports arsenite and antimonite; required for resistance to arsenic compounds; transcription is activated by Arr1p in the presence of arsenite; Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.


ensembl_gene_id: YPR202W
symbol: YPR202W
gene_biotype: protein_coding
description:
  Putative protein of unknown function; similar to telomere-encoded helicases; down-regulated at low calcium levels; YPR202W is not an essential gene; transcript is predicted to be spliced but there is no evidence that it is spliced in vivo.


