# geneInfo

ensembl_gene_id: Q0010
symbol: Q0010
gene_biotype: protein_coding
description:
  Putative uncharacterized protein Q0010, mitochondrial; Dubious open reading frame; unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF Q0017.


ensembl_gene_id: Q0017
symbol: Q0017
gene_biotype: protein_coding
description:
  Putative uncharacterized protein Q0017, mitochondrial; Dubious open reading frame; unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF Q0010.


ensembl_gene_id: Q0032
symbol: Q0032
gene_biotype: protein_coding
description:
  Putative uncharacterized protein Q0032, mitochondrial; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: Q0045
symbol: COX1
gene_biotype: protein_coding
description:
  Subunit I of cytochrome c oxidase (Complex IV); Complex IV is the terminal member of the mitochondrial inner membrane electron transport chain; one of three mitochondrially-encoded subunits; Belongs to the heme-copper respiratory oxidase family.


ensembl_gene_id: Q0050
symbol: AI1
gene_biotype: protein_coding
description:
  Putative COX1/OXI3 intron 1 protein; Reverse transcriptase required for splicing of the COX1 pre-mRNA; encoded by a mobile group II intron within the mitochondrial COX1 gene.


ensembl_gene_id: Q0055
symbol: AI2
gene_biotype: protein_coding
description:
  Putative COX1/OXI3 intron 2 protein; Reverse transcriptase required for splicing of the COX1 pre-mRNA; encoded by a mobile group II intron within the mitochondrial COX1 gene.


ensembl_gene_id: Q0060
symbol: AI3
gene_biotype: protein_coding
description:
  Truncated non-functional cytochrome oxidase 1; Endonuclease I-SceIII; encoded by a mobile group I intron within the mitochondrial COX1 gene.


ensembl_gene_id: Q0065
symbol: AI4
gene_biotype: protein_coding
description:
  Truncated non-functional cytochrome oxidase 1; Endonuclease I-SceII; encoded by a mobile group I intron within the mitochondrial COX1 gene; intron is normally spliced by the BI4p maturase but AI4p can mutate to acquire the same maturase activity.


ensembl_gene_id: Q0070
symbol: AI5_ALPHA
gene_biotype: protein_coding
description:
  Truncated non-functional cytochrome oxidase 1; Endonuclease I-SceIV; involved in intron mobility; encoded by a mobile group I intron within the mitochondrial COX1 gene; In the N-terminal section; belongs to the heme-copper respiratory oxidase family.


ensembl_gene_id: Q0075
symbol: AI5_BETA
gene_biotype: protein_coding
description:
  Intron-encoded DNA endonuclease aI5 beta; Protein of unknown function; encoded within an intron of the mitochondrial COX1 gene; translational initiation codon is predicted to be ATA rather than ATG.


ensembl_gene_id: Q0080
symbol: ATP8
gene_biotype: protein_coding
description:
  ATP synthase protein 8; Subunit 8 of the F0 sector of mitochondrial F1F0 ATP synthase; encoded on the mitochondrial genome; ATP8 and ATP6 mRNAs are not translated in the absence of the F1 sector of ATPase.


ensembl_gene_id: Q0085
symbol: ATP6
gene_biotype: protein_coding
description:
  Subunit a of the F0 sector of mitochondrial F1F0 ATP synthase; mitochondrially encoded; translation is specifically activated by Atp22p; ATP6 and ATP8 mRNAs are not translated in the absence of the F1 sector of ATPase; mutations in human ortholog MT-ATP6 are associated with neurodegenerative disorders such as Neurogenic Ataxia and Retinitis Pigmentosa (NARP), Leigh syndrome (LS), Charcot-Marie-Tooth (CMT), and ataxia telangiectasia.


ensembl_gene_id: Q0092
symbol: Q0092
gene_biotype: protein_coding
description:
  Putative uncharacterized protein Q0092, mitochondrial; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: Q0105
symbol: COB
gene_biotype: protein_coding
description:
  Cytochrome b; mitochondrially encoded subunit of the ubiquinol-cytochrome c reductase complex which includes Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p.


ensembl_gene_id: Q0110
symbol: BI2
gene_biotype: protein_coding
description:
  Cytochrome b mRNA maturase bI2; Mitochondrial mRNA maturase with a role in splicing; encoded by both exon and intron sequences of partially processed COB mRNA; In the N-terminal section; belongs to the cytochrome b family.


ensembl_gene_id: Q0115
symbol: BI3
gene_biotype: protein_coding
description:
  Cytochrome b mRNA maturase bI3; Mitochondrial mRNA maturase; forms a complex with Mrs1p to mediate splicing of the bI3 intron of the COB gene; encoded by both exon and intron sequences of partially processed COB mRNA.


ensembl_gene_id: Q0120
symbol: BI4
gene_biotype: protein_coding
description:
  Truncated, nonfunctional cytochrome b; Mitochondrial mRNA maturase; forms a complex with Nam2p to mediate splicing of the bI4 intron of the COB gene; encoded by both exon and intron sequences of partially processed COB mRNA.


ensembl_gene_id: Q0130
symbol: OLI1
gene_biotype: protein_coding
description:
  F0-ATP synthase subunit c (ATPase-associated proteolipid); encoded on the mitochondrial genome; mutation confers oligomycin resistance; expression is specifically dependent on the nuclear genes AEP1 and AEP2.


ensembl_gene_id: Q0140
symbol: VAR1
gene_biotype: protein_coding
description:
  Mitochondrial ribosomal protein of the small subunit; mitochondrially-encoded; polymorphic in different strains due to variation in number of AAT (asparagine) codons; translated near the mitochondrial inner membrane; may have a role in loss of mitochondrial DNA under stress conditions.


ensembl_gene_id: Q0142
symbol: Q0142
gene_biotype: protein_coding
description:
  Putative uncharacterized protein Q0142, mitochondrial; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps dubious open reading frame Q0143.


ensembl_gene_id: Q0143
symbol: Q0143
gene_biotype: protein_coding
description:
  Putative uncharacterized protein Q0143, mitochondrial; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: Q0144
symbol: Q0144
gene_biotype: protein_coding
description:
  Putative uncharacterized protein Q0144, mitochondrial; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: Q0160
symbol: SCEI
gene_biotype: protein_coding
description:
  I-SceI DNA endonuclease; encoded by the mitochondrial group I intron of the 21S_rRNA gene; mediates gene conversion that propagates the intron into intron-less copies of the 21S_rRNA gene.


ensembl_gene_id: Q0182
symbol: Q0182
gene_biotype: protein_coding
description:
  Putative uncharacterized protein Q0182, mitochondrial; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: Q0250
symbol: COX2
gene_biotype: protein_coding
description:
  Subunit II of cytochrome c oxidase (Complex IV); Complex IV is the terminal member of the mitochondrial inner membrane electron transport chain; one of three mitochondrially-encoded subunits.


ensembl_gene_id: Q0275
symbol: COX3
gene_biotype: protein_coding
description:
  Subunit III of cytochrome c oxidase (Complex IV); Complex IV is the terminal member of the mitochondrial inner membrane electron transport chain; one of three mitochondrially-encoded subunits.


ensembl_gene_id: Q0297
symbol: Q0297
gene_biotype: protein_coding
description:
  Putative uncharacterized protein Q0297, mitochondrial; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene RPM1.


ensembl_gene_id: YAL001C
symbol: TFC3
gene_biotype: protein_coding
description:
  Subunit of RNA polymerase III transcription initiation factor complex; part of the TauB domain of TFIIIC that binds DNA at the BoxB promoter sites of tRNA and similar genes; cooperates with Tfc6p in DNA binding; largest of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC).


ensembl_gene_id: YAL002W
symbol: VPS8
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 8; Membrane-binding component of the CORVET complex; involved in endosomal vesicle tethering and fusion in the endosome to vacuole protein targeting pathway; interacts with Vps21p; contains RING finger motif.


ensembl_gene_id: YAL003W
symbol: EFB1
gene_biotype: protein_coding
description:
  Translation elongation factor 1 beta; stimulates nucleotide exchange to regenerate EF-1 alpha-GTP for the next elongation cycle; part of the EF-1 complex, which facilitates binding of aminoacyl-tRNA to the ribosomal A site; human homolog EEF1B2 can complement yeast efb1 mutants; Belongs to the EF-1-beta/EF-1-delta family.


ensembl_gene_id: YAL004W
symbol: YAL004W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YAL004W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps verified gene SSA1/YAL005C.


ensembl_gene_id: YAL005C
symbol: SSA1
gene_biotype: protein_coding
description:
  Heat shock protein SSA1; ATPase involved in protein folding and NLS-directed nuclear transport; member of HSP70 family; required for ubiquitin-dependent degradation of short-lived proteins; forms chaperone complex with Ydj1p; localized to nucleus, cytoplasm, cell wall; 98% identical to paralog Ssa2p with different functional specificity in propagation of yeast [URE3] prions, vacuolar-mediated degradations of gluconeogenesis enzymes; general targeting factor of Hsp104p to prion fibrils.


ensembl_gene_id: YAL007C
symbol: ERP2
gene_biotype: protein_coding
description:
  Protein ERP2; Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; role in misfolded protein quality control; forms a heterotrimeric complex with Erp1p, Emp24p, and Erv25p; localized to COPII-coated vesicles; ERP2 has a paralog, ERP4, that arose from the whole genome duplication.


ensembl_gene_id: YAL008W
symbol: FUN14
gene_biotype: protein_coding
description:
  Protein FUN14; Integral mitochondrial outer membrane (MOM) protein; dosage suppressor of an MDM10 null that reduces ERMES-related phenotypes, such as alterations in mitochondrial morphology, protein complex assembly, and lipid profile; dosage suppressor of MDM12, MDM34, and MMM1 null mutant growth defects; novel mechanism of MOM import involving Tom70p, the TOM complex, and the TIM23 complex, requiring mitochondrial membrane potential and processing by the IMP complex for correct biogenesis; Belongs to the FUN14 family.


ensembl_gene_id: YAL009W
symbol: SPO7
gene_biotype: protein_coding
description:
  Sporulation-specific protein SPO7; Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology, premeiotic replication, and sporulation.


ensembl_gene_id: YAL010C
symbol: MDM10
gene_biotype: protein_coding
description:
  Mitochondrial distribution and morphology protein 10; Subunit of both the ERMES and the SAM complex; component of ERMES complex which acts as a molecular tether between the mitochondria and the ER, necessary for efficient phospholipid exchange between organelles and for mitophagy; SAM/TOB complex component that functions in the assembly of outer membrane beta-barrel proteins; involved in mitochondrial inheritance and morphology; ERMES complex is often co-localized with peroxisomes and concentrated areas of pyruvate dehydrogenase; Belongs to the MDM10 family.


ensembl_gene_id: YAL011W
symbol: SWC3
gene_biotype: protein_coding
description:
  SWR1-complex protein 3; Protein of unknown function; component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae; Belongs to the SWC3 family.


ensembl_gene_id: YAL012W
symbol: CYS3
gene_biotype: protein_coding
description:
  Cystathionine gamma-lyase; catalyzes one of the two reactions involved in the transsulfuration pathway that yields cysteine from homocysteine with the intermediary formation of cystathionine; protein abundance increases in response to DNA replication stress; Belongs to the trans-sulfuration enzymes family.


ensembl_gene_id: YAL013W
symbol: DEP1
gene_biotype: protein_coding
description:
  Transcriptional regulatory protein DEP1; Component of the Rpd3L histone deacetylase complex; required for diauxic shift-induced histone H2B deposition onto rDNA genes; transcriptional modulator involved in regulation of structural phospholipid biosynthesis genes and metabolically unrelated genes, as well as maintenance of telomeres, mating efficiency, and sporulation.


ensembl_gene_id: YAL015C
symbol: NTG1
gene_biotype: protein_coding
description:
  Endonuclease III homolog 1; DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; required for maintaining mitochondrial genome integrity; NTG1 has a paralog, NTG2, that arose from the whole genome duplication; Belongs to the Nth/MutY family.


ensembl_gene_id: YAL016C-A
symbol: YAL016C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized membrane protein YAL016C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps ORF TPD3/YAL016W.


ensembl_gene_id: YAL016C-B
symbol: YAL016C-B
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YAL016C-B; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YAL016W
symbol: TPD3
gene_biotype: protein_coding
description:
  Regulatory subunit A of the heterotrimeric PP2A complex; the heterotrimeric protein phosphatase 2A (PP2A) complex also contains regulatory subunit Cdc55p and either catalytic subunit Pph21p or Pph22p; required for cell morphogenesis and transcription by RNA polymerase III.


ensembl_gene_id: YAL017W
symbol: PSK1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase PSK1; PAS domain-containing serine/threonine protein kinase; coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status; PSK1 has a paralog, PSK2, that arose from the whole genome duplication.


ensembl_gene_id: YAL018C
symbol: LDS1
gene_biotype: protein_coding
description:
  Protein Involved in spore wall assembly; localizes to lipid droplets found on or outside of the prospore membrane; shares similarity with Lds2p and Rrt8p, and a strain mutant for all 3 genes exhibits reduced dityrosine fluorescence relative to the single mutants.


ensembl_gene_id: YAL019W
symbol: FUN30
gene_biotype: protein_coding
description:
  ATP-dependent helicase FUN30; Snf2p family member with ATP-dependent chromatin remodeling activity; has a role in silencing at the mating type locus, telomeres and centromeres; enriched at centromeres and is required for correct chromatin structure around centromeres, as well as at the boundary element of the silent HMR; recruited to DNA double-strand breaks (DSBs) where it promotes 5' strand resection of DSBs; potential Cdc28p substrate.


ensembl_gene_id: YAL019W-A
symbol: YAL019W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YAL019W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps ORF ATS1/YAL020C.


ensembl_gene_id: YAL020C
symbol: ATS1
gene_biotype: protein_coding
description:
  Protein required for modification of wobble nucleosides in tRNA; acts with Elongator complex, Kti11p, and Kti12p; has a potential role in regulatory interactions between microtubules and the cell cycle; forms a stable heterodimer with Kti11p.


ensembl_gene_id: YAL021C
symbol: CCR4
gene_biotype: protein_coding
description:
  Glucose-repressible alcohol dehydrogenase transcriptional effector; Component of the CCR4-NOT transcriptional complex; CCR4-NOT is involved in regulation of gene expression; component of the major cytoplasmic deadenylase, which is involved in mRNA poly(A) tail shortening; Belongs to the CCR4/nocturin family.


ensembl_gene_id: YAL022C
symbol: FUN26
gene_biotype: protein_coding
description:
  Nucleoside transporter FUN26; High affinity, broad selectivity, nucleoside/nucleobase transporter; vacuolar membrane localized transporter which may regulate the balance of nicotinamide riboside (NmR) levels between the cytosol and vacuole, contributing to salvage of NmR for use in cytosolic NAD+ synthesis; equilibrative nucleoside transporter (ENT) family member.


ensembl_gene_id: YAL023C
symbol: PMT2
gene_biotype: protein_coding
description:
  Dolichyl-phosphate-mannose--protein mannosyltransferase 2; Protein O-mannosyltransferase of the ER membrane; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; involved in ER quality control; acts in a complex with Pmt1p, can instead interact with Pmt5p; antifungal drug target; PMT2 has a paralog, PMT3, that arose from the whole genome duplication.


ensembl_gene_id: YAL024C
symbol: LTE1
gene_biotype: protein_coding
description:
  Guanine nucleotide exchange factor LTE1; Protein similar to GDP/GTP exchange factors; without detectable GEF activity; required for asymmetric localization of Bfa1p at daughter-directed spindle pole bodies and for mitotic exit at low temperatures.


ensembl_gene_id: YAL025C
symbol: MAK16
gene_biotype: protein_coding
description:
  Essential nuclear protein; constituent of 66S pre-ribosomal particles; required for maturation of 25S and 5.8S rRNAs; required for maintenance of M1 satellite double-stranded RNA of the L-A virus.


ensembl_gene_id: YAL026C
symbol: DRS2
gene_biotype: protein_coding
description:
  Probable phospholipid-transporting ATPase DRS2; Trans-golgi network aminophospholipid translocase (flippase); maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation, endocytosis, protein trafficking between the Golgi and endosomal system and the cellular response to mating pheromone; autoinhibited by its C-terminal tail; localizes to the trans-Golgi network; mutations in human homolog ATP8B1 result in liver disease; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.


ensembl_gene_id: YAL026C-A
symbol: YAL026C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized membrane protein YAL026C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YAL027W and the verified gene DRS2.


ensembl_gene_id: YAL027W
symbol: SAW1
gene_biotype: protein_coding
description:
  5'- and 3'-flap DNA binding protein; recruits Rad1p-Rad10p to single-strand annealing intermediates with 3' non-homologous tails for removal during double-strand break repair; complexes with Rad1p-Rad10p and stimulates its endonuclease activity; green fluorescent protein (GFP)-fusion protein localizes to the nucleus.


ensembl_gene_id: YAL028W
symbol: FRT2
gene_biotype: protein_coding
description:
  Protein HPH2; Tail-anchored ER membrane protein of unknown function; interacts with homolog Frt1p; promotes growth in conditions of high Na+, alkaline pH, or cell wall stress, possibly via a role in posttranslational translocation; potential Cdc28p substrate; FRT2 has a paralog, FRT1, that arose from the whole genome duplication.


ensembl_gene_id: YAL029C
symbol: MYO4
gene_biotype: protein_coding
description:
  Myosin-4; Type V myosin motor involved in actin-based transport of cargos; required for mRNA transport, including ASH1 mRNA, and facilitating the growth and movement of ER tubules into the growing bud along with She3p; MYO4 has a paralog, MYO2, that arose from the whole genome duplication.


ensembl_gene_id: YAL030W
symbol: SNC1
gene_biotype: protein_coding
description:
  Synaptobrevin homolog 1; Vesicle membrane receptor protein (v-SNARE); involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; proposed to be involved in endocytosis; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins; SNC1 has a paralog, SNC2, that arose from the whole genome duplication.


ensembl_gene_id: YAL031C
symbol: GIP4
gene_biotype: protein_coding
description:
  GLC7-interacting protein 4; Cytoplasmic protein that regulates protein phosphatase 1 Glc7p; protein overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; potential Cdc28p substrate.


ensembl_gene_id: YAL031W-A
symbol: YAL031W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized membrane protein YAL031W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps ORF GIP4/YAL031C.


ensembl_gene_id: YAL032C
symbol: PRP45
gene_biotype: protein_coding
description:
  Pre-mRNA-processing protein 45; Protein required for pre-mRNA splicing; associates with the spliceosome and interacts with splicing factors Prp22p and Prp46p; orthologous to human transcriptional coactivator SKIP and can activate transcription of a reporter gene.


ensembl_gene_id: YAL033W
symbol: POP5
gene_biotype: protein_coding
description:
  Ribonuclease P/MRP protein subunit POP5; Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs.


ensembl_gene_id: YAL034C
symbol: FUN19
gene_biotype: protein_coding
description:
  SWIRM domain-containing protein FUN19; Non-essential protein of unknown function; expression induced in response to heat stress; FUN19 has a paralog, YOR338W, that arose from the whole genome duplication.


ensembl_gene_id: YAL034C-B
symbol: YAL034C-B
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YAL034C-B; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YAL034W-A
symbol: MTW1
gene_biotype: protein_coding
description:
  Kinetochore-associated protein MTW1; Essential component of the MIND kinetochore complex; joins kinetochore subunits contacting DNA to those contacting microtubules; critical to kinetochore assembly; complex consists of Mtw1p Including Nnf1p-Nsl1p-Dsn1p (MIND).


ensembl_gene_id: YAL035W
symbol: FUN12
gene_biotype: protein_coding
description:
  Translation initiation factor eIF5B; GTPase that promotes Met-tRNAiMet binding to ribosomes and ribosomal subunit joining; promotes GTP-dependent maturation of 18S rRNA by Nob1p; protein abundance increases in response to DNA replication stress; homolog of bacterial IF2.


ensembl_gene_id: YAL036C
symbol: RBG1
gene_biotype: protein_coding
description:
  Ribosome-interacting GTPase 1; Member of the DRG family of GTP-binding proteins; associates with translating ribosomes; interacts with Tma46p, Ygr250cp, Gir2p and Yap1p via two-hybrid; Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.


ensembl_gene_id: YAL037C-B
symbol: YAL037C-B
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YAL037C-B; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching.


ensembl_gene_id: YAL037W
symbol: YAL037W
gene_biotype: protein_coding
description:
  Putative protein of unknown function; YAL037W has a paralog, YOR342C, that arose from the whole genome duplication.


ensembl_gene_id: YAL038W
symbol: CDC19
gene_biotype: protein_coding
description:
  Pyruvate kinase; functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration; regulated via allosteric activation by fructose bisphosphate; CDC19 has a paralog, PYK2, that arose from the whole genome duplication.


ensembl_gene_id: YAL039C
symbol: CYC3
gene_biotype: protein_coding
description:
  Cytochrome c heme lyase (holocytochrome c synthase); attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in mitochondrial intermembrane space; human homolog HCCS implicated in microphthalmia with linear skin defects (MLS), and can complement yeast null mutant.


ensembl_gene_id: YAL040C
symbol: CLN3
gene_biotype: protein_coding
description:
  G1/S-specific cyclin CLN3; G1 cyclin involved in cell cycle progression; activates Cdc28p kinase to promote G1 to S phase transition; plays a role in regulating transcription of other G1 cyclins, CLN1 and CLN2; regulated by phosphorylation and proteolysis; acetyl-CoA induces CLN3 transcription in response to nutrient repletion to promote cell-cycle entry; cell cycle arrest phenotype of the cln1 cln2 cln3 triple null mutant is complemented by any of human cyclins CCNA2, CCNB1, CCNC, CCND1, or CCNE1.


ensembl_gene_id: YAL041W
symbol: CDC24
gene_biotype: protein_coding
description:
  Cell division control protein 24; Guanine nucleotide exchange factor (GEF) for Cdc42p; required for polarity establishment and maintenance, and mutants have morphological defects in bud formation and shmooing; relocalizes from nucleus to cytoplasm upon DNA replication stress; thermosensitivity of the cdc24-4 mutant in the presence of sorbitol is functionally complemented by human CDC42.


ensembl_gene_id: YAL042C-A
symbol: YAL042C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YAL042C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified ORF ERV46/YAL042W; YAL042C-A is a non-essential gene.


ensembl_gene_id: YAL042W
symbol: ERV46
gene_biotype: protein_coding
description:
  Protein localized to COPII-coated vesicles; forms a complex with Erv41p; involved in the membrane fusion stage of transport; Belongs to the ERGIC family.


ensembl_gene_id: YAL043C
symbol: PTA1
gene_biotype: protein_coding
description:
  Pre-tRNA-processing protein PTA1; Subunit of holo-CPF; holo-CPF is a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII.


ensembl_gene_id: YAL044C
symbol: GCV3
gene_biotype: protein_coding
description:
  H subunit of the mitochondrial glycine decarboxylase complex; glycine decarboxylase is required for the catabolism of glycine to 5,10-methylene-THF; also required for all protein lipoylation; expression is regulated by levels of 5,10-methylene-THF; Belongs to the GcvH family.


ensembl_gene_id: YAL044W-A
symbol: BOL1
gene_biotype: protein_coding
description:
  BolA-like protein 1; Mitochondrial matrix protein involved in Fe-S cluster biogenesis; facilitates [4Fe-2S] cluster inception into mitochondrial proteins such as lipoate synthase and succinate dehydrogenase; interacts and may function with Grx5p at an early step in Fe-S cluster biosynthesis; forms dimeric complexes with Grx5p and Nfu1p that alter the stability of shared Fe/S clusters; sequence similarity to human BOLA family member, BOLA1 and S. pombe uvi31, a putative DNA repair protein.


ensembl_gene_id: YAL045C
symbol: YAL045C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YAL045C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps YAL044W-A.


ensembl_gene_id: YAL046C
symbol: BOL3
gene_biotype: protein_coding
description:
  BolA-like protein 3; Protein involved in Fe-S cluster transfer to mitochondrial clients; protects [4Fe-4S] clusters from damage due to oxidative stress by acting along with Nfu1p at a late step in the transfer of [4Fe-4S] clusters from the ISA complex to mitochondrial client proteins like lipoate synthase and succinate dehydrogenase; sequence similarity to human BOLA family member, BOLA3, mutations of which are associated with Multiple Mitochondria Dysfunctions Syndrome (MMDS2).


ensembl_gene_id: YAL047C
symbol: SPC72
gene_biotype: protein_coding
description:
  Spindle pole component SPC72; Gamma-tubulin small complex (gamma-TuSC) receptor; recruits the gamma-TuSC complex to the cytoplasmic side of the SPB, connecting nuclear microtubules to the SPB; involved in astral microtubule formation, stabilization, and with Stu2p, anchoring astral MTs at the cytoplasmic face of the SPB, and regulating plus-end MT dynamics; regulated by Cdc5 kinase.


ensembl_gene_id: YAL047W-A
symbol: YAL047W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized membrane protein YAL047W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps ORF GEM1/YAL048C.


ensembl_gene_id: YAL048C
symbol: GEM1
gene_biotype: protein_coding
description:
  Outer mitochondrial membrane GTPase, subunit of the ERMES complex; potential regulatory subunit of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth; cells lacking Gem1p contain collapsed, globular, or grape-like mitochondria; ortholog of metazoan Miro GTPases.


ensembl_gene_id: YAL049C
symbol: AIM2
gene_biotype: protein_coding
description:
  Cytoplasmic protein involved in mitochondrial function or organization; null mutant displays reduced frequency of mitochondrial genome loss; potential Hsp82p interactor; Belongs to the AIM2 family.


ensembl_gene_id: YAL051W
symbol: OAF1
gene_biotype: protein_coding
description:
  Oleate-activated transcription factor; subunit of a heterodimeric complex with Pip2p, which binds to oleate-response elements (ORE) in the promoter of genes involved in beta-oxidation of fatty acids, peroxisome organization and biogenesis, activating transcription in the presence of oleate; regulates chromatin silencing at telomeres; involved in diauxic shift; OAF1 has a paralog, PIP2, that arose from the whole genome duplication.


ensembl_gene_id: YAL053W
symbol: FLC2
gene_biotype: protein_coding
description:
  Flavin carrier protein 2; Putative calcium channel involved in calcium release under hypotonic stress; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; FLC2 has a paralog, YOR365C, that arose from the whole genome duplication.


ensembl_gene_id: YAL054C
symbol: ACS1
gene_biotype: protein_coding
description:
  Acetyl-coA synthetase isoform; along with Acs2p, acetyl-coA synthetase isoform is the nuclear source of acetyl-coA for histone acetylation; expressed during growth on nonfermentable carbon sources and under aerobic conditions; Belongs to the ATP-dependent AMP-binding enzyme family.


ensembl_gene_id: YAL055W
symbol: PEX22
gene_biotype: protein_coding
description:
  Peroxisome assembly protein 22; Putative peroxisomal membrane protein; required for import of peroxisomal proteins; functionally complements a Pichia pastoris pex22 mutation; Belongs to the peroxin-22 family.


ensembl_gene_id: YAL056C-A
symbol: YAL056C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YAL056C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YAL056W
symbol: GPB2
gene_biotype: protein_coding
description:
  Guanine nucleotide-binding protein subunit beta 2; Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; inhibits Ras activity through direct interactions with Ira1p/2p; regulated by G-alpha protein Gpa2p; GPB2 has a paralog, GPB1, that arose from the whole genome duplication.


ensembl_gene_id: YAL058W
symbol: CNE1
gene_biotype: protein_coding
description:
  Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast.


ensembl_gene_id: YAL059C-A
symbol: YAL059C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized membrane protein YAL059C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified gene ECM1/YAL059W.


ensembl_gene_id: YAL059W
symbol: ECM1
gene_biotype: protein_coding
description:
  Shuttling pre-60S factor ECM1; Pre-ribosomal factor involved in 60S ribosomal protein subunit export; associates with the pre-60S particle; shuttles between the nucleus and cytoplasm; Belongs to the ECM1 family.


ensembl_gene_id: YAL060W
symbol: BDH1
gene_biotype: protein_coding
description:
  NAD-dependent (R,R)-butanediol dehydrogenase; catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source.


ensembl_gene_id: YAL061W
symbol: BDH2
gene_biotype: protein_coding
description:
  Probable diacetyl reductase [(R)-acetoin forming] 2; Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3; Belongs to the zinc-containing alcohol dehydrogenase family.


ensembl_gene_id: YAL062W
symbol: GDH3
gene_biotype: protein_coding
description:
  NADP(+)-dependent glutamate dehydrogenase; synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources; GDH3 has a paralog, GDH1, that arose from the whole genome duplication; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.


ensembl_gene_id: YAL063C
symbol: FLO9
gene_biotype: protein_coding
description:
  Flocculation protein FLO9; Lectin-like protein with similarity to Flo1p; thought to be expressed and involved in flocculation; Belongs to the flocculin family.


ensembl_gene_id: YAL063C-A
symbol: YAL063C-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YAL063C-A; Putative protein of unknown function; identified by expression profiling and mass spectrometry.


ensembl_gene_id: YAL064C-A
symbol: TDA8
gene_biotype: protein_coding
description:
  Topoisomerase I damage affected protein 8; Putative protein of unknown function; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene.


ensembl_gene_id: YAL064W
symbol: YAL064W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YAL064W; Protein of unknown function; may interact with ribosomes, based on co-purification experiments.


ensembl_gene_id: YAL065C
symbol: YAL065C
gene_biotype: protein_coding
description:
  Uncharacterized protein YAL065C; Putative protein of unknown function; shows sequence similarity to FLO1 and other flocculins.


ensembl_gene_id: YAL066W
symbol: YAL066W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YAL066W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YAL067C
symbol: SEO1
gene_biotype: protein_coding
description:
  Probable transporter SEO1; Putative permease; member of the allantoate transporter subfamily of the major facilitator superfamily; mutation confers resistance to ethionine sulfoxide.


ensembl_gene_id: YAL067W-A
symbol: YAL067W-A
gene_biotype: protein_coding
description:
  Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; Belongs to the UPF0377 family.


ensembl_gene_id: YAL068C
symbol: PAU8
gene_biotype: protein_coding
description:
  Seripauperin-11; Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions; Belongs to the SRP1/TIP1 family. Seripauperin subfamily.


ensembl_gene_id: YAL068W-A
symbol: YAL068W-A
gene_biotype: protein_coding
description:
  Putative UPF0320 protein YAL068W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching.


ensembl_gene_id: YAL069W
symbol: YAL069W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YAL069W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YAR002C-A
symbol: ERP1
gene_biotype: protein_coding
description:
  Protein ERP1; Member of the p24 family involved in ER to Golgi transport; role in misfolded protein quality control; forms heterotrimeric complex with Erp2p, Emp24p, and Erv25p; localized to COPII-coated vesicles; ERP1 has a paralog, ERP6, that arose from the whole genome duplication.


ensembl_gene_id: YAR002W
symbol: NUP60
gene_biotype: protein_coding
description:
  FG-nucleoporin component of central core of the nuclear pore complex; contributes directly to nucleocytoplasmic transport and maintenance of the nuclear pore complex (NPC) permeability barrier and is involved in gene tethering at the nuclear periphery; relocalizes to the cytosol in response to hypoxia; both NUP1 and NUP60 are homologous to human NUP153.


ensembl_gene_id: YAR003W
symbol: SWD1
gene_biotype: protein_coding
description:
  COMPASS component SWD1; Subunit of the COMPASS (Set1C) complex; COMPASS methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member with similarity to mammalian Rbbp7.


ensembl_gene_id: YAR007C
symbol: RFA1
gene_biotype: protein_coding
description:
  Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination; RPA protects against inappropriate telomere recombination, and upon telomere uncapping, prevents cell proliferation by a checkpoint-independent pathway; role in DNA catenation/decatenation pathway of chromosome disentangling; relocalizes to the cytosol in response to hypoxia.


ensembl_gene_id: YAR008W
symbol: SEN34
gene_biotype: protein_coding
description:
  Subunit of the tRNA splicing endonuclease; tRNA splicing endonuclease (Sen complex) is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen complex also cleaves the CBP1 mRNA at the mitochondrial surface; Sen34p contains the active site for tRNA 3' splice site cleavage and has similarity to Sen2p and to Archaeal tRNA splicing endonuclease.


ensembl_gene_id: YAR014C
symbol: BUD14
gene_biotype: protein_coding
description:
  Protein involved in bud-site selection; Bud14p-Glc7p complex is a cortical regulator of dynein; forms a complex with Kel1p and Kel2p that regulates Bnr1p (formin) to affect actin cable assembly, cytokinesis, and polarized growth; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; relative distribution to the nucleus increases upon DNA replication stress.


ensembl_gene_id: YAR015W
symbol: ADE1
gene_biotype: protein_coding
description:
  Phosphoribosylaminoimidazole-succinocarboxamide synthase; N-succinyl-5-aminoimidazole-4-carboxamide ribotide synthetase; required for 'de novo' purine nucleotide biosynthesis; red pigment accumulates in mutant cells deprived of adenine; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YAR018C
symbol: KIN3
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase KIN3; Nonessential serine/threonine protein kinase; possible role in DNA damage response; influences tolerance to high levels of ethanol.


ensembl_gene_id: YAR019C
symbol: CDC15
gene_biotype: protein_coding
description:
  Cell division control protein 15; Protein kinase of the Mitotic Exit Network; localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p; required for spindle disassembly after meiosis II; relocalizes to the cytoplasm upon DNA replication stress.


ensembl_gene_id: YAR019W-A
symbol: YAR019W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YAR019W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps ORF CDC15/YAR019C.


ensembl_gene_id: YAR020C
symbol: PAU7
gene_biotype: protein_coding
description:
  Seripauperin-7; Member of the seripauperin multigene family; active during alcoholic fermentation, regulated by anaerobiosis, inhibited by oxygen, repressed by heme; Belongs to the SRP1/TIP1 family. Seripauperin subfamily.


ensembl_gene_id: YAR027W
symbol: UIP3
gene_biotype: protein_coding
description:
  ULP1-interacting protein 3; Putative integral membrane protein of unknown function; interacts with Ulp1p at the nuclear periphery; member of DUP240 gene family; Belongs to the DUP/COS family.


ensembl_gene_id: YAR028W
symbol: YAR028W
gene_biotype: protein_coding
description:
  DUP240 protein YAR028W; Putative integral membrane protein; member of DUP240 gene family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS.


ensembl_gene_id: YAR029W
symbol: YAR029W
gene_biotype: protein_coding
description:
  DUP240 protein YAR029W; Member of DUP240 gene family but contains no transmembrane domains; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; Belongs to the DUP/COS family.


ensembl_gene_id: YAR030C
symbol: YAR030C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YAR030C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YAR029W and the verified gene PRM9.


ensembl_gene_id: YAR031W
symbol: PRM9
gene_biotype: protein_coding
description:
  Pheromone-regulated protein; contains 3 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; member of DUP240 gene family; PRM9 has a paralog, PRM8, that arose from a segmental duplication.


ensembl_gene_id: YAR033W
symbol: MST28
gene_biotype: protein_coding
description:
  Multicopy suppressor of SEC21 protein 28; Putative integral membrane protein, involved in vesicle formation; forms complex with Mst27p; member of DUP240 gene family; binds COPI and COPII vesicles; MST28 has a paralog, MST27, that arose from a segmental duplication.


ensembl_gene_id: YAR035C-A
symbol: YAR035C-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YAR035C-A; Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; predicted to have a role in cell budding based on computational guilt by association analysis.


ensembl_gene_id: YAR035W
symbol: YAT1
gene_biotype: protein_coding
description:
  Outer mitochondrial carnitine acetyltransferase; minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated.


ensembl_gene_id: YAR042W
symbol: SWH1
gene_biotype: protein_coding
description:
  Protein similar to mammalian oxysterol-binding protein; contains ankyrin repeats and FFAT motif; interacts with ER anchor Scs2p at the nucleus-vacuole junction; regulated by sterol binding; SWH1 has a paralog, OSH2, that arose from the whole genome duplication; Belongs to the OSBP family.


ensembl_gene_id: YAR047C
symbol: YAR047C
gene_biotype: protein_coding
description:
  Putative uncharacterized membrane protein YAR047C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YAR050W
symbol: FLO1
gene_biotype: protein_coding
description:
  Lectin-like protein involved in flocculation; cell wall protein that binds mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; important for co-flocculation with other yeasts, mediating interaction with specific species; FLO1 has a paralog, FLO5, that arose from a segmental duplication; Belongs to the flocculin family.


ensembl_gene_id: YAR053W
symbol: YAR053W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YA5053W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YAR060C
symbol: YAR060C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YAR060C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; YAR060C has a paralog, YHR212C, that arose from a segmental duplication.


ensembl_gene_id: YAR064W
symbol: YAR064W
gene_biotype: protein_coding
description:
  Uncharacterized protein YAR064W; Pseudogenic fragment with similarity to flocculins; YAR064W has a paralog, YHR213W-B, that arose from a segmental duplication.


ensembl_gene_id: YAR066W
symbol: YAR066W
gene_biotype: protein_coding
description:
  Putative GPI protein; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively; YAR066W has a paralog, YHR214W, that arose from a segmental duplication.


ensembl_gene_id: YAR068W
symbol: YAR068W
gene_biotype: protein_coding
description:
  Uncharacterized protein YAR068W; Fungal-specific protein of unknown function; induced in respiratory-deficient cells; YAR068W has a paralog, YHR214W-A, that arose from a segmental duplication.


ensembl_gene_id: YAR069C
symbol: YAR069C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YAR069C; Dubious open reading frame; unlikely to encode a protein, based on available experimental and comparative sequence data; YAR069C has a paralog, YHR214C-D, that arose from a segmental duplication.


ensembl_gene_id: YAR070C
symbol: YAR070C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YAR070C; Dubious open reading frame; unlikely to encode a protein, based on available experimental and comparative sequence data; YAR070C has a paralog, YHR214C-B, that arose from a segmental duplication.


ensembl_gene_id: YAR071W
symbol: PHO11
gene_biotype: protein_coding
description:
  One of three repressible acid phosphatases; glycoprotein that is transported to the cell surface by the secretory pathway; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2; PHO11 has a paralog, PHO12, that arose from a segmental duplication.


ensembl_gene_id: YAR073W
symbol: IMD1
gene_biotype: protein_coding
description:
  Putative inosine-5'-monophosphate dehydrogenase 1; Nonfunctional protein with homology to IMP dehydrogenase; blocked reading frame, located close to the telomere; not expressed at detectable levels; YAR073W and YAR075W comprise a continuous reading frame in most strains of S. cerevisiae; YAR073W/YAR075W together have a paralog, IMD2, that arose from a segmental duplication.


ensembl_gene_id: YAR075W
symbol: YAR075W
gene_biotype: protein_coding
description:
  Putative inosine-5'-monophosphate dehydrogenase-like protein YAR075W; Non-functional protein with homology IMP dehydrogenase; YAR073W/IMD1 and YAR075W comprise a continuous reading frame in most strains of S. cerevisiae; YAR073W/YAR075W together have a paralog, IMD2, that arose from a segmental duplication; Belongs to the IMPDH/GMPR family.


ensembl_gene_id: YBL001C
symbol: ECM15
gene_biotype: protein_coding
description:
  UPF0045 protein ECM15; Non-essential protein of unknown function; likely exists as tetramer, may be regulated by the binding of small-molecule ligands (possibly sulfate ions), may have a role in yeast cell-wall biogenesis.


ensembl_gene_id: YBL002W
symbol: HTB2
gene_biotype: protein_coding
description:
  Histone H2B; core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB1; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates reassembly after DNA replication, transcriptional activation, meiotic DSB formation and H3 methylation.


ensembl_gene_id: YBL003C
symbol: HTA2
gene_biotype: protein_coding
description:
  Histone H2A; core histone protein required for chromatin assembly and chromosome function; one of two nearly identical (see also HTA1) subtypes; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p.


ensembl_gene_id: YBL004W
symbol: UTP20
gene_biotype: protein_coding
description:
  U3 small nucleolar RNA-associated protein 20; Component of the small-subunit (SSU) processome; SSU processome is involved in the biogenesis of the 18S rRNA; Belongs to the UTP20 family.


ensembl_gene_id: YBL005W
symbol: PDR3
gene_biotype: protein_coding
description:
  Transcription factor PDR3; Transcriptional activator of the pleiotropic drug resistance network; regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting PDRE sites (PDR responsive elements); has a role in response to drugs and organic solvents; post-translationally up-regulated in cells lacking functional mitochondrial genome; involved in diauxic shift; relative distribution to nucleus increases upon DNA replication stress; APCC(Cdh1) substrate.


ensembl_gene_id: YBL006C
symbol: LDB7
gene_biotype: protein_coding
description:
  Chromatin structure-remodeling complex protein RSC14; Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions.


ensembl_gene_id: YBL006W-A
symbol: YBL006W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YBL006W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified gene LDB7/YBL006C.


ensembl_gene_id: YBL007C
symbol: SLA1
gene_biotype: protein_coding
description:
  Actin cytoskeleton-regulatory complex protein SLA1; Cytoskeletal protein binding protein; required for assembly of the cortical actin cytoskeleton; interacts with proteins regulating actin dynamics and proteins required for endocytosis; found in the nucleus and cell cortex; has 3 SH3 domains; Belongs to the SLA1 family.


ensembl_gene_id: YBL008W
symbol: HIR1
gene_biotype: protein_coding
description:
  Protein HIR1; Subunit of the HIR complex; HIR is a nucleosome assembly complex involved in regulation of histone gene transcription; contributes to nucleosome formation, heterochromatic gene silencing, and formation of functional kinetochores.


ensembl_gene_id: YBL008W-A
symbol: YBL008W-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YBL008W-A; Putative protein of unknown function; identified by fungal homology and RT-PCR.


ensembl_gene_id: YBL009W
symbol: ALK2
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase Haspin homolog ALK2; Protein kinase; along with its paralog, ALK1, required for proper spindle positioning and nuclear segregation following mitotic arrest, proper organization of cell polarity factors in mitosis, proper localization of formins and polarity factors, and survival in cells that activate spindle assembly checkpoint; phosphorylated in response to DNA damage; ALK2 has a paralog, ALK1, that arose from the whole genome duplication; similar to mammalian haspins.


ensembl_gene_id: YBL010C
symbol: YBL010C
gene_biotype: protein_coding
description:
  Uncharacterized protein YBL010C; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein colocalizes with clathrin-coated vesicles; Belongs to the bZIP family.


ensembl_gene_id: YBL011W
symbol: SCT1
gene_biotype: protein_coding
description:
  Glycerol-3-phosphate O-acyltransferase 1; Glycerol 3-phosphate/dihydroxyacetone phosphate sn-1 acyltransferase; dual substrate-specific acyltransferase of the glycerolipid biosynthesis pathway; prefers 16-carbon fatty acids; similar to Gpt2p; gene is constitutively transcribed.


ensembl_gene_id: YBL012C
symbol: YBL012C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YBL012C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YBL013W
symbol: FMT1
gene_biotype: protein_coding
description:
  Methionyl-tRNA formyltransferase, mitochondrial; Methionyl-tRNA formyltransferase; catalyzes the formylation of initiator Met-tRNA in mitochondria; potential Cdc28p substrate.


ensembl_gene_id: YBL014C
symbol: RRN6
gene_biotype: protein_coding
description:
  RNA polymerase I-specific transcription initiation factor RRN6; Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p.


ensembl_gene_id: YBL015W
symbol: ACH1
gene_biotype: protein_coding
description:
  Acetyl-CoA hydrolase; Protein with CoA transferase activity; particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth; Belongs to the acetyl-CoA hydrolase/transferase family.


ensembl_gene_id: YBL016W
symbol: FUS3
gene_biotype: protein_coding
description:
  Mitogen-activated serine/threonine protein kinase involved in mating; phosphoactivated by Ste7p; substrates include Ste12p, Far1p, Bni1p, Sst2p; inhibits invasive growth during mating by phosphorylating Tec1p, promoting its; inhibits recruitment of Ste5p, Cdc42p-mediated asymmetry and mating morphogenesis.


ensembl_gene_id: YBL017C
symbol: PEP1
gene_biotype: protein_coding
description:
  Vacuolar protein sorting/targeting protein VPS10; Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments; Belongs to the VPS10-related sortilin family.


ensembl_gene_id: YBL018C
symbol: POP8
gene_biotype: protein_coding
description:
  Ribonucleases P/MRP protein subunit POP8; Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; relocalizes to the cytosol in response to hypoxia.


ensembl_gene_id: YBL019W
symbol: APN2
gene_biotype: protein_coding
description:
  DNA-(apurinic or apyrimidinic site) lyase 2; Class II abasic (AP) endonuclease involved in repair of DNA damage; homolog of human HAP1 and E. coli exoIII.


ensembl_gene_id: YBL020W
symbol: RFT1
gene_biotype: protein_coding
description:
  Membrane protein required for translocation of Man5GlcNac2-PP-Dol; required for translocation of Man5GlcNac2-PP-Dol from the cytoplasmic side to the lumenal side of the ER membrane but is not the flippase; mutation is suppressed by expression of human p53 protein; essential gene; Belongs to the RFT1 family.


ensembl_gene_id: YBL021C
symbol: HAP3
gene_biotype: protein_coding
description:
  Transcriptional activator HAP3; Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex; complex is heme-activated and glucose-repressed; complex is a transcriptional activator and global regulator of respiratory gene expression; contains sequences contributing to both complex assembly and DNA binding.


ensembl_gene_id: YBL022C
symbol: PIM1
gene_biotype: protein_coding
description:
  ATP-dependent Lon protease; involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria; Belongs to the peptidase S16 family.


ensembl_gene_id: YBL023C
symbol: MCM2
gene_biotype: protein_coding
description:
  Protein involved in DNA replication; component of the Mcm2-7 hexameric helicase complex that binds chromatin as a part of the pre-replicative complex; relative distribution to the nucleus increases upon DNA replication stress.


ensembl_gene_id: YBL024W
symbol: NCL1
gene_biotype: protein_coding
description:
  Multisite-specific tRNA:(cytosine-C(5))-methyltransferase; S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase; methylates cytosine to m5C at several positions in tRNAs and intron-containing pre-tRNAs; increases proportion of tRNALeu(CAA) with m5C at wobble position in response to hydrogen peroxide, causing selective translation of mRNA from genes enriched in TTG codon; loss of NCL1 confers hypersensitivity to oxidative stress; similar to Nop2p and human proliferation associated nucleolar protein p120.


ensembl_gene_id: YBL025W
symbol: RRN10
gene_biotype: protein_coding
description:
  Protein involved in promoting high level transcription of rDNA; subunit of UAF (upstream activation factor) for RNA polymerase I.


ensembl_gene_id: YBL026W
symbol: LSM2
gene_biotype: protein_coding
description:
  U6 snRNA-associated Sm-like protein LSm2; Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress.


ensembl_gene_id: YBL027W
symbol: RPL19B
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L19B; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal; homologous to mammalian ribosomal protein L19, no bacterial homolog; RPL19B has a paralog, RPL19A, that arose from the whole genome duplication.


ensembl_gene_id: YBL028C
symbol: YBL028C
gene_biotype: protein_coding
description:
  UPF0642 protein YBL028C; Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis.


ensembl_gene_id: YBL029C-A
symbol: YBL029C-A
gene_biotype: protein_coding
description:
  UPF0768 protein YBL029C-A; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; protein abundance increases in response to DNA replication stress; has potential orthologs in Saccharomyces species and in Yarrowia lipolytica; Belongs to the UPF0768 family.


ensembl_gene_id: YBL030C
symbol: PET9
gene_biotype: protein_coding
description:
  ADP,ATP carrier protein 2; Major ADP/ATP carrier of the mitochondrial inner membrane; exchanges cytosolic ADP for mitochondrially synthesized ATP; also imports heme and ATP; required for viability in many lab strains that carry a sal1 mutation; PET9 has a paralog, AAC3, that arose from the whole genome duplication; human homolog SLC25A4 implicated in progressive external ophthalmoplegia can complement yeast null mutant.


ensembl_gene_id: YBL031W
symbol: SHE1
gene_biotype: protein_coding
description:
  Mitotic spindle protein; interacts with components of the Dam1 (DASH) complex, its effector Sli15p, and microtubule-associated protein Bim1p; also localizes to nuclear microtubules and to the bud neck in a ring-shaped structure; inhibits dynein function.


ensembl_gene_id: YBL032W
symbol: HEK2
gene_biotype: protein_coding
description:
  Heterogeneous nuclear rnp K-like protein 2; RNA binding protein involved in asymmetric localization of ASH1 mRNA; represses translation of ASH1 mRNA, an effect reversed by Yck1p-dependent phosphoryation; regulates telomere position effect and length; similarity to hnRNP-K.


ensembl_gene_id: YBL034C
symbol: STU1
gene_biotype: protein_coding
description:
  Protein STU1; Component of the mitotic spindle; binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles; Belongs to the CLASP family.


ensembl_gene_id: YBL035C
symbol: POL12
gene_biotype: protein_coding
description:
  B subunit of DNA polymerase alpha-primase complex; required for initiation of DNA replication during mitotic and premeiotic DNA synthesis; also functions in telomere capping and length regulation.


ensembl_gene_id: YBL036C
symbol: YBL036C
gene_biotype: protein_coding
description:
  Pyridoxal phosphate homeostasis protein; Putative non-specific single-domain racemase; based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS.


ensembl_gene_id: YBL037W
symbol: APL3
gene_biotype: protein_coding
description:
  Alpha-adaptin; large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport.


ensembl_gene_id: YBL038W
symbol: MRPL16
gene_biotype: protein_coding
description:
  Mitochondrial ribosomal protein of the large subunit; homologous to bacterial L16 ribosomal protein; synthetic lethality with hac1 mutation suggests a possible role in synthesis of precursors for protein glycosylation.


ensembl_gene_id: YBL039C
symbol: URA7
gene_biotype: protein_coding
description:
  Major CTP synthase isozyme (see also URA8); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA7 has a paralog, URA8, that arose from the whole genome duplication.


ensembl_gene_id: YBL039C-A
symbol: YBL039C-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YBL039C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF URA7; identified by expression profiling and mass spectrometry.


ensembl_gene_id: YBL039W-B
symbol: YBL039W-B
gene_biotype: protein_coding
description:
  Uncharacterized protein YBL039W-B; Putative protein of unknown function; mCherry fusion protein localizes to the vacuole.


ensembl_gene_id: YBL040C
symbol: ERD2
gene_biotype: protein_coding
description:
  ER lumen protein-retaining receptor; HDEL receptor; an integral membrane protein that binds to the HDEL motif in proteins destined for retention in the endoplasmic reticulum; has a role in maintenance of normal levels of ER-resident proteins; Belongs to the ERD2 family.


ensembl_gene_id: YBL042C
symbol: FUI1
gene_biotype: protein_coding
description:
  High affinity uridine permease, localizes to the plasma membrane; also mediates low but significant transport of the cytotoxic nucleoside analog 5-fluorouridine; not involved in uracil transport; relative distribution to the vacuole increases upon DNA replication stress; Belongs to the purine-cytosine permease (2.A.39) family.


ensembl_gene_id: YBL043W
symbol: ECM13
gene_biotype: protein_coding
description:
  Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; ECM13 has a paralog, YJR115W, that arose from the whole genome duplication.


ensembl_gene_id: YBL045C
symbol: COR1
gene_biotype: protein_coding
description:
  Core subunit of the ubiquinol-cytochrome c reductase complex; the ubiquinol-cytochrome c reductase complex (bc1 complex) is a component of the mitochondrial inner membrane electron transport chain.


ensembl_gene_id: YBL046W
symbol: PSY4
gene_biotype: protein_coding
description:
  Regulatory subunit of protein phosphatase PP4; presence of Psy4p in the PP4 complex (along with catalytic subunit Pph3p and Psy2p) is required for dephosphorylation of the histone variant H2AX, but not for dephosphorylation of Rad53p, during recovery from the DNA damage checkpoint; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; required for cisplatin resistance; homolog of mammalian R2.


ensembl_gene_id: YBL047C
symbol: EDE1
gene_biotype: protein_coding
description:
  EH domain-containing and endocytosis protein 1; Scaffold protein involved in the formation of early endocytic sites; putative regulator of cytokinesis; homo-oligomerization is required for localization to and organization of endocytic sites; has a network of interactions with other endocytic proteins; binds membranes in a ubiquitin-dependent manner; may also bind ubiquitinated membrane-associated proteins; interacts with Cmk2 and functions upstream of CMK2 in regulating non-apoptotic cell death; homolog of mammalian Eps15; Belongs to the VDP/USO1/EDE1 family.


ensembl_gene_id: YBL048W
symbol: RRT1
gene_biotype: protein_coding
description:
  Regulator of rDNA transcription protein 1; Protein of unknown function; identified in a screen for mutants with increased levels of rDNA transcription; dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data.


ensembl_gene_id: YBL049W
symbol: MOH1
gene_biotype: protein_coding
description:
  Protein yippee-like MOH1; Protein of unknown function, essential for stationary phase survival; not required for growth on nonfermentable carbon sources; possibly linked with vacuolar transport; Belongs to the yippee family.


ensembl_gene_id: YBL050W
symbol: SEC17
gene_biotype: protein_coding
description:
  Alpha-soluble NSF attachment protein; Alpha-SNAP cochaperone; SNARE-complex adaptor for Sec18 (NSF) during the disassembly of postfusion cis-SNARE complexes; stimulates the ATPase activity of Sec18p; peripheral membrane protein required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, and autophagy; similar to mammalian alpha-SNAP.


ensembl_gene_id: YBL051C
symbol: PIN4
gene_biotype: protein_coding
description:
  RNA-binding protein PIN4; Protein involved in G2/M phase progression and response to DNA damage; interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage.


ensembl_gene_id: YBL052C
symbol: SAS3
gene_biotype: protein_coding
description:
  Histone acetyltransferase catalytic subunit of NuA3 complex; acetylates histone H3, involved in transcriptional silencing; homolog of the mammalian MOZ proto-oncogene; mutant has aneuploidy tolerance; sas3gcn5 double mutation is lethal; Belongs to the MYST (SAS/MOZ) family.


ensembl_gene_id: YBL053W
symbol: YBL053W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YBL053W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YBL054W
symbol: TOD6
gene_biotype: protein_coding
description:
  Transcriptional regulatory protein TOD6; PAC motif binding protein involved in rRNA and ribosome biogenesis; subunit of the RPD3L histone deacetylase complex; Myb-like HTH transcription factor; hypophosphorylated by rapamycin treatment in a Sch9p-dependent manner; activated in stochastic pulses of nuclear localization; Belongs to the DOT6 family.


ensembl_gene_id: YBL055C
symbol: YBL055C
gene_biotype: protein_coding
description:
  Deoxyribonuclease Tat-D; 3'-->5' exonuclease and endonuclease with a possible role in apoptosis; has similarity to mammalian and C. elegans apoptotic nucleases.


ensembl_gene_id: YBL056W
symbol: PTC3
gene_biotype: protein_coding
description:
  Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p (see also Ptc2p) to limit maximal kinase activity induced by osmotic stress; dephosphorylates T169 phosphorylated Cdc28p (see also Ptc2p); role in DNA damage checkpoint inactivation; PTC3 has a paralog, PTC2, that arose from the whole genome duplication.


ensembl_gene_id: YBL057C
symbol: PTH2
gene_biotype: protein_coding
description:
  Peptidyl-tRNA hydrolase 2; One of two mitochondrially-localized peptidyl-tRNA hydrolases; negatively regulates the ubiquitin-proteasome pathway via interactions with ubiquitin-like ubiquitin-associated proteins; dispensable for cell growth; see also PTH1.


ensembl_gene_id: YBL058W
symbol: SHP1
gene_biotype: protein_coding
description:
  UBX domain-containing substrate adaptor for Cdc48p; ubiquitin regulatory X domain-containing protein that acts as a substrate recruiting cofactor for Cdc48p; positively regulates Glc7p PPase activity to promote growth and mitotic progression in complex with Cdc48p; ubiquitinated protein interactor involved in ER-associated degradation (ERAD); regulated by nuclear Ub-dependent degradation (INMAD pathway) independent of the Asi and Doa10 complexes; homolog of human p47 (NSFL1C).


ensembl_gene_id: YBL059C-A
symbol: CMC2
gene_biotype: protein_coding
description:
  COX assembly mitochondrial protein 2; Protein involved in respiratory chain complex assembly or maintenance; protein of the mitochondrial intermembrane space; contains twin Cx9C motifs that can form coiled coil-helix-coiled-coil helix fold.


ensembl_gene_id: YBL059W
symbol: YBL059W
gene_biotype: protein_coding
description:
  Uncharacterized protein YBL059W; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YBL059W has a paralog, YER093C-A, that arose from the whole genome duplication.


ensembl_gene_id: YBL060W
symbol: YEL1
gene_biotype: protein_coding
description:
  Guanine nucleotide exchange factor specific for Arf3p; localized to the bud neck and tip; required for localization of Arf3p to the bud neck and tip; Belongs to the YEL1 family.


ensembl_gene_id: YBL061C
symbol: SKT5
gene_biotype: protein_coding
description:
  Protein SKT5; Activator of Chs3p (chitin synthase III) during vegetative growth; recruits Chs3p to the bud neck via interaction with Bni4p; SKT5 has a paralog, SHC1, that arose from the whole genome duplication.


ensembl_gene_id: YBL062W
symbol: YBL062W
gene_biotype: protein_coding
description:
  Putative uncharacterized membrane protein YBL062W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YBL063W
symbol: KIP1
gene_biotype: protein_coding
description:
  Kinesin-like protein KIP1; Kinesin-related motor protein; required for mitotic spindle assembly, chromosome segregation, and 2 micron plasmid partitioning; functionally redundant with Cin8p for chromosomal but not plasmid functions; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. BimC subfamily.


ensembl_gene_id: YBL064C
symbol: PRX1
gene_biotype: protein_coding
description:
  Mitochondrial peroxiredoxin with thioredoxin peroxidase activity; has a role in reduction of hydroperoxides; reactivation requires Trr2p and glutathione; induced during respiratory growth and oxidative stress; phosphorylated; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YBL065W
symbol: YBL065W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YBL065W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified ORF SEF1/YBL066C; YBL065W is a non-essential gene.


ensembl_gene_id: YBL067C
symbol: UBP13
gene_biotype: protein_coding
description:
  Ubiquitin-specific protease that cleaves Ub-protein fusions; UBP13 has a paralog, UBP9, that arose from the whole genome duplication; Belongs to the peptidase C19 family.


ensembl_gene_id: YBL068W
symbol: PRS4
gene_biotype: protein_coding
description:
  Ribose-phosphate pyrophosphokinase 4; 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP; which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS4 has a paralog, PRS2, that arose from the whole genome duplication; a missense mutation in the conserved residue R196 of its human homolog PRPS1 is pathogenic; Belongs to the ribose-phosphate pyrophosphokinase family.


ensembl_gene_id: YBL068W-A
symbol: YBL068W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YBL068W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by fungal homology and RT-PCR.


ensembl_gene_id: YBL069W
symbol: AST1
gene_biotype: protein_coding
description:
  Protein AST1; Lipid raft associated protein; interacts with the plasma membrane ATPase Pma1p and has a role in its targeting to the plasma membrane by influencing its incorporation into lipid rafts; sometimes classified in the medium-chain dehydrogenase/reductases (MDRs) superfamily; AST1 has a paralog, AST2, that arose from the whole genome duplication.


ensembl_gene_id: YBL070C
symbol: YBL070C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YBL070C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YBL071C
symbol: YBL071C
gene_biotype: protein_coding
description:
  Uncharacterized protein YBL071C; Putative protein of unknown function; conserved among S. cerevisiae strains; YBL071C is not an essential gene.


ensembl_gene_id: YBL071C-B
symbol: YBL071C-B
gene_biotype: protein_coding
description:
  Uncharacterized protein YBL071C-B; Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching.


ensembl_gene_id: YBL071W-A
symbol: KTI11
gene_biotype: protein_coding
description:
  Diphthamide biosynthesis protein 3; Zn-ribbon protein that co-purifies with Dph1 and Dph2; in a complex required for synthesis of diphthamide on translation factor eEF2 and with Elongator subunits Iki3p, Elp2p, and Elp3p; involved in modification of wobble nucleosides in tRNAs; forms a stable heterodimer with Ats1p; Belongs to the DPH3 family.


ensembl_gene_id: YBL072C
symbol: RPS8A
gene_biotype: protein_coding
description:
  Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S8, no bacterial homolog; RPS8A has a paralog, RPS8B, that arose from the whole genome duplication.


ensembl_gene_id: YBL073W
symbol: YBL073W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YBL073W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the essential gene AAR2/YBL074C.


ensembl_gene_id: YBL074C
symbol: AAR2
gene_biotype: protein_coding
description:
  A1 cistron-splicing factor AAR2; Component of the U5 snRNP complex; required for splicing of U3 precursors; originally described as a splicing factor specifically required for splicing pre-mRNA of the MATa1 cistron; Belongs to the AAR2 family.


ensembl_gene_id: YBL075C
symbol: SSA3
gene_biotype: protein_coding
description:
  Heat shock protein SSA3; ATPase involved in protein folding and the response to stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm; SSA3 has a paralog, SSA4, that arose from the whole genome duplication.


ensembl_gene_id: YBL076C
symbol: ILS1
gene_biotype: protein_coding
description:
  Isoleucine--tRNA ligase, cytoplasmic; Cytoplasmic isoleucine-tRNA synthetase; target of the G1-specific inhibitor reveromycin A.


ensembl_gene_id: YBL077W
symbol: YBL077W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YBL077W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ILS1/YBL076C.


ensembl_gene_id: YBL078C
symbol: ATG8
gene_biotype: protein_coding
description:
  Autophagy-related protein 8; Component of autophagosomes and Cvt vesicles; regulator of Atg1p, targets it to autophagosomes; binds the Atg1p-Atg13p complex, triggering its vacuolar degradation; unique ubiquitin-like protein whose conjugation target is lipid phosphatidylethanolamine (PE); Atg8p-PE is anchored to membranes, is involved in phagophore expansion, and may mediate membrane fusion during autophagosome formation; deconjugation of Atg8p-PE is required for efficient autophagosome biogenesis.


ensembl_gene_id: YBL079W
symbol: NUP170
gene_biotype: protein_coding
description:
  Nucleoporin NUP170; Subunit of inner ring of nuclear pore complex (NPC); contributes to NPC assembly and nucleocytoplasmic transport; interacts with genomic regions that contain ribosomal protein and subtelomeric genes, where it functions in nucleosome positioning and as a repressor of transcription; both Nup170p and NUP157p are similar to human Nup155p; NUP170 has a paralog, NUP157, that arose from the whole genome duplication.


ensembl_gene_id: YBL080C
symbol: PET112
gene_biotype: protein_coding
description:
  Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial; Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; mutation is functionally complemented by the bacterial GatB ortholog; Belongs to the GatB/GatE family. GatB subfamily.


ensembl_gene_id: YBL081W
symbol: YBL081W
gene_biotype: protein_coding
description:
  Uncharacterized protein YBL081W; Non-essential protein of unknown function; null mutation results in a decrease in plasma membrane electron transport.


ensembl_gene_id: YBL082C
symbol: ALG3
gene_biotype: protein_coding
description:
  Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase; Dolichol-P-Man dependent alpha(1-3) mannosyltransferase; involved in synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins; G353A missense mutation in human ortholog ALG3 implicated in carbohydrate deficient glycoprotein syndrome type IV, which is characterized by microcephaly, severe epilepsy, minimal psychomotor development, partial deficiency of sialic acids in serum glycoproteins; wild-type human ALG3 can complement yeast alg3 mutant; Belongs to the glycosyltransferase 58 family.


ensembl_gene_id: YBL083C
symbol: YBL083C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YBL083C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps verified ORF ALG3.


ensembl_gene_id: YBL084C
symbol: CDC27
gene_biotype: protein_coding
description:
  Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition.


ensembl_gene_id: YBL085W
symbol: BOI1
gene_biotype: protein_coding
description:
  Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication.


ensembl_gene_id: YBL086C
symbol: YBL086C
gene_biotype: protein_coding
description:
  Uncharacterized protein YBL086C; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery.


ensembl_gene_id: YBL087C
symbol: RPL23A
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L23A; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23A has a paralog, RPL23B, that arose from the whole genome duplication.


ensembl_gene_id: YBL088C
symbol: TEL1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase TEL1; Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; acts with Red1p and Mec1p to promote interhomolog recombination by phosphorylation of Hop1; functionally redundant with Mec1p; regulates P-body formation induced by replication stress; homolog of human ataxia-telangiectasia mutated (ATM) gene.


ensembl_gene_id: YBL089W
symbol: AVT5
gene_biotype: protein_coding
description:
  Vacuolar amino acid transporter 5; Putative transporter; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters; AVT5 has a paralog, AVT6, that arose from the whole genome duplication; Belongs to the amino acid/polyamine transporter 2 family.


ensembl_gene_id: YBL090W
symbol: MRP21
gene_biotype: protein_coding
description:
  Mitochondrial ribosomal protein of the small subunit; MRP21 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences.


ensembl_gene_id: YBL091C
symbol: MAP2
gene_biotype: protein_coding
description:
  Methionine aminopeptidase; catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map1p; Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.


ensembl_gene_id: YBL091C-A
symbol: SCS22
gene_biotype: protein_coding
description:
  Vesicle-associated membrane protein-associated protein SCS22; Protein involved in regulation of phospholipid metabolism; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect the ER and plasma membrane (PM); regulates PM PI4P levels by controlling access of the Sac1p phosphatase to its substrate, PI4P; human VAP homolog; similar to D. melanogaster inturned protein; SWAT-GFP and mCherry fusion proteins localize to the cytosol; SCS22 has a paralog, SCS2, that arose from the whole genome duplication; Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.


ensembl_gene_id: YBL092W
symbol: RPL32
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L32; overexpression disrupts telomeric silencing; homologous to mammalian ribosomal protein L32, no bacterial homolog.


ensembl_gene_id: YBL093C
symbol: ROX3
gene_biotype: protein_coding
description:
  Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme.


ensembl_gene_id: YBL094C
symbol: YBL094C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YBL094C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YBL095W.


ensembl_gene_id: YBL095W
symbol: MRX3
gene_biotype: protein_coding
description:
  MIOREX complex component 3; Protein that associates with mitochondrial ribosome; likely functions in cristae junction formation; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies.


ensembl_gene_id: YBL097W
symbol: BRN1
gene_biotype: protein_coding
description:
  Subunit of the condensin complex; required for chromosome condensation and for clustering of tRNA genes at the nucleolus; may influence multiple aspects of chromosome transmission.


ensembl_gene_id: YBL098W
symbol: BNA4
gene_biotype: protein_coding
description:
  Kynurenine 3-monooxygenase; required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p; putative therapeutic target for Huntington disease.


ensembl_gene_id: YBL099W
symbol: ATP1
gene_biotype: protein_coding
description:
  Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase; which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; F1 translationally regulates ATP6 and ATP8 expression to achieve a balanced output of ATP synthase genes encoded in nucleus and mitochondria; phosphorylated; N-terminally propionylated in vivo; Belongs to the ATPase alpha/beta chains family.


ensembl_gene_id: YBL100C
symbol: YBL100C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YBL100C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps the 5' end of ATP1.


ensembl_gene_id: YBL100W-C
symbol: YBL100W-C
gene_biotype: protein_coding
description:
  Uncharacterized protein YBL100W-C; Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching.


ensembl_gene_id: YBL101C
symbol: ECM21
gene_biotype: protein_coding
description:
  Protein involved in regulating endocytosis of plasma membrane proteins; identified as a substrate for ubiquitination by Rsp5p and deubiquitination by Ubp2p; promoter contains several Gcn4p binding elements; ECM21 has a paralog, CSR2, that arose from the whole genome duplication.


ensembl_gene_id: YBL102W
symbol: SFT2
gene_biotype: protein_coding
description:
  Tetra-spanning membrane protein found mostly in the late Golgi; non-essential; can suppress some sed5 alleles; may be part of the transport machinery, but precise function is unknown; similar to mammalian syntaxin 5; Belongs to the SFT2 family.


ensembl_gene_id: YBL103C
symbol: RTG3
gene_biotype: protein_coding
description:
  Retrograde regulation protein 3; bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways; forms a complex with another bHLH/Zip protein, Rtg1p, to activate the pathways; target of Hog1p.


ensembl_gene_id: YBL104C
symbol: SEA4
gene_biotype: protein_coding
description:
  SEH-associated protein 4; Subunit of SEACAT, a subcomplex of the SEA complex; Sea4p, along with Rtc1p and Mtc5p, redundantly inhibit the TORC1 inhibitory role of the Iml1p/SEACIT (Iml1p-Npr2p-Npr3p) subcomplex, a GAP for GTPase Gtr1p (EGOC subunit) in response to amino acid limitation, thereby resulting in activation of TORC1 signaling; SEA is a coatomer-related complex that associates dynamically with the vacuole; contains an N-terminal beta-propeller fold and a C-terminal RING motif.


ensembl_gene_id: YBL105C
symbol: PKC1
gene_biotype: protein_coding
description:
  Protein serine/threonine kinase; essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC).


ensembl_gene_id: YBL106C
symbol: SRO77
gene_biotype: protein_coding
description:
  Lethal(2) giant larvae protein homolog SRO77; Protein with roles in exocytosis and cation homeostasis; functions in docking and fusion of post-Golgi vesicles with plasma membrane; regulates cell proliferation and colony development via the Rho1-Tor1 pathway; interacts with SNARE protein Sec9p; homolog of Drosophila lethal giant larvae tumor suppressor; SRO77 has a paralog, SRO7, that arose from the whole genome duplication; Belongs to the WD repeat L(2)GL family.


ensembl_gene_id: YBL107C
symbol: MIX23
gene_biotype: protein_coding
description:
  Mitochondrial intermembrane space protein of unknown function; imported via the MIA import machinery; contains an unusual twin cysteine motif (CX13C CX14C).


ensembl_gene_id: YBL107W-A
symbol: YBL107W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YBL107W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the Ty2 LTR YBLWdelta2; YBL107W-A has a paralog, YER138W-A, that arose from a single-locus duplication.


ensembl_gene_id: YBL108C-A
symbol: PAU9
gene_biotype: protein_coding
description:
  Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively.


ensembl_gene_id: YBL108W
symbol: YBL108W
gene_biotype: protein_coding
description:
  Putative UPF0377 protein YBL108W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; Belongs to the UPF0377 family.


ensembl_gene_id: YBL109W
symbol: YBL109W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YBL109W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YBL111C
symbol: YBL111C
gene_biotype: protein_coding
description:
  Helicase-like protein encoded within the telomeric Y' element; relocalizes from mitochondrion to cytoplasm upon DNA replication stress.


ensembl_gene_id: YBL113W-A
symbol: YBL113W-A
gene_biotype: protein_coding
description:
  Putative UPF0479 protein YBL113W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; Belongs to the UPF0479 family.


ensembl_gene_id: YBR001C
symbol: NTH2
gene_biotype: protein_coding
description:
  Putative neutral trehalase, required for thermotolerance; may mediate resistance to other cellular stresses; NTH2 has a paralog, NTH1, that arose from the whole genome duplication; Belongs to the glycosyl hydrolase 37 family.


ensembl_gene_id: YBR002C
symbol: RER2
gene_biotype: protein_coding
description:
  Forms the dehydrodolichyl diphosphate syntase (DDS) complex with NUS1; major enzyme of polyprenol synthesis in both the endoplasmic reticulum (ER) and in lipid droplets; participates in ER protein sorting; human ortholog DHDDS functionally complements the heat sensitive growth defect of a ts allele, and is associated with retinitis pigmentosa; Belongs to the UPP synthase family.


ensembl_gene_id: YBR003W
symbol: COQ1
gene_biotype: protein_coding
description:
  Hexaprenyl pyrophosphate synthetase; catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis; Belongs to the FPP/GGPP synthase family.


ensembl_gene_id: YBR004C
symbol: GPI18
gene_biotype: protein_coding
description:
  GPI mannosyltransferase 2; Functional ortholog of human PIG-V; PIG-V is a mannosyltransferase that transfers the second mannose in glycosylphosphatidylinositol biosynthesis; the authentic, non-tagged protein was localized to mitochondria; Belongs to the PIGV family.


ensembl_gene_id: YBR005W
symbol: RCR1
gene_biotype: protein_coding
description:
  Protein of the ER membrane involved in cell wall chitin deposition; may function in the endosomal-vacuolar trafficking pathway, helping determine whether plasma membrane proteins are degraded or routed to the plasma membrane; RCR1 has a paralog, RCR2, that arose from the whole genome duplication.


ensembl_gene_id: YBR006W
symbol: UGA2
gene_biotype: protein_coding
description:
  Succinate-semialdehyde dehydrogenase [NADP(+)]; Succinate semialdehyde dehydrogenase; involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of the 4-aminobutyrate and glutamate degradation pathways; localized to the cytoplasm.


ensembl_gene_id: YBR007C
symbol: DSF2
gene_biotype: protein_coding
description:
  Protein DSF2; Deletion suppressor of mpt5 mutation; relocalizes from bud neck to cytoplasm upon DNA replication stress.


ensembl_gene_id: YBR008C
symbol: FLR1
gene_biotype: protein_coding
description:
  Fluconazole resistance protein 1; Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; involved in efflux of fluconazole, diazaborine, benomyl, methotrexate, and other drugs; expression induced in cells treated with the mycotoxin patulin; relocalizes from nucleus to plasma membrane upon DNA replication stress.


ensembl_gene_id: YBR009C
symbol: HHF1
gene_biotype: protein_coding
description:
  Histone H4; core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF2); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity.


ensembl_gene_id: YBR010W
symbol: HHT1
gene_biotype: protein_coding
description:
  Histone H3; core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT2); regulated by acetylation, methylation, and phosphorylation; H3K14 acetylation plays an important role in the unfolding of strongly positioned nucleosomes during repair of UV damage.


ensembl_gene_id: YBR011C
symbol: IPP1
gene_biotype: protein_coding
description:
  Cytoplasmic inorganic pyrophosphatase (PPase); homodimer that catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential for viability, active-site residues show identity to those from E. coli PPase.


ensembl_gene_id: YBR012C
symbol: YBR012C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YBR012C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by iron-regulated transcriptional activator Aft2p.


ensembl_gene_id: YBR013C
symbol: YBR013C
gene_biotype: protein_coding
description:
  Putative protein of unknown function; haploid deletion mutant exhibits synthetic phenotype with alpha-synuclein; SWAT-GFP fusion protein localizes to the endoplasmic reticulum while mCherry fusion protein localizes to both the endoplasmic reticulum and vacuole.


ensembl_gene_id: YBR014C
symbol: GRX7
gene_biotype: protein_coding
description:
  Cis-golgi localized monothiol glutaredoxin; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; does not bind metal ions; GRX7 has a paralog, GRX6, that arose from the whole genome duplication.


ensembl_gene_id: YBR015C
symbol: MNN2
gene_biotype: protein_coding
description:
  Alpha-1,2-mannosyltransferase; responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment; Belongs to the MNN1/MNT family.


ensembl_gene_id: YBR016W
symbol: YBR016W
gene_biotype: protein_coding
description:
  Uncharacterized protein YBR016W; Tail-anchored plasma membrane protein with a conserved CYSTM module; predicted to be palmitoylated; has similarity to hydrophilins, which are involved in the adaptive response to hyperosmotic conditions; YBR016W has a paralog, YDL012C, that arose from the whole genome duplication.


ensembl_gene_id: YBR017C
symbol: KAP104
gene_biotype: protein_coding
description:
  Importin subunit beta-2; Transportin or cytosolic karyopherin beta 2; functions in the rg-nuclear localization signal-mediated nuclear import/reimport of mRNA-binding proteins Nab2p and Hrp1p; regulates asymmetric protein synthesis in daughter cells during mitosis; Belongs to the importin beta family. Importin beta-2 subfamily.


ensembl_gene_id: YBR018C
symbol: GAL7
gene_biotype: protein_coding
description:
  Galactose-1-phosphate uridyl transferase; synthesizes glucose-1-phosphate and UDP-galactose from UDP-D-glucose and alpha-D-galactose-1-phosphate in the second step of galactose catabolism; human homolog UGP2 can complement yeast null mutant.


ensembl_gene_id: YBR019C
symbol: GAL10
gene_biotype: protein_coding
description:
  Bifunctional protein GAL10; UDP-glucose-4-epimerase; catalyzes interconversion of UDP-galactose and UDP-D-glucose in galactose metabolism; also catalyzes conversion of alpha-D-glucose or alpha-D-galactose to their beta-anomers; human homolog GALE implicated in galactosemia, can complement yeast null mutant.


ensembl_gene_id: YBR020W
symbol: GAL1
gene_biotype: protein_coding
description:
  Galactokinase; phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p; human homolog GALK2 complements yeast null mutant; GAL1 has a paralog, GAL3, that arose from the whole genome duplication.


ensembl_gene_id: YBR021W
symbol: FUR4
gene_biotype: protein_coding
description:
  Uracil permease; Plasma membrane localized uracil permease; expression is tightly regulated by uracil levels and environmental cues; conformational alterations induced by unfolding or substrate binding result in Rsp5p-mediated ubiquitination and degradation.


ensembl_gene_id: YBR022W
symbol: POA1
gene_biotype: protein_coding
description:
  Phosphatase that is highly specific for ADP-ribose 1''-phosphate; a tRNA splicing metabolite; may have a role in regulation of tRNA splicing; Belongs to the POA1 family.


ensembl_gene_id: YBR023C
symbol: CHS3
gene_biotype: protein_coding
description:
  Chitin synthase III; catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan; contains overlapping di-leucine and di-acidic signals that mediate, respectively, intracellular trafficking by AP-1 and trafficking to plasma membrane by exomer complex; requires AP-3 complex for its intracellular retention.


ensembl_gene_id: YBR024W
symbol: SCO2
gene_biotype: protein_coding
description:
  Protein anchored to mitochondrial inner membrane; may have a redundant function with Sco1p in delivery of copper to cytochrome c oxidase; interacts with Cox2p; SCO2 has a paralog, SCO1, that arose from the whole genome duplication.


ensembl_gene_id: YBR025C
symbol: OLA1
gene_biotype: protein_coding
description:
  Obg-like ATPase 1; P-loop ATPase with similarity to human OLA1 and bacterial YchF; identified as specifically interacting with the proteasome; null mutant displays increased translation rate and increased readthrough of premature stop codons; protein abundance increases in response to hydrogen peroxide and to DNA replication stress; Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.


ensembl_gene_id: YBR026C
symbol: ETR1
gene_biotype: protein_coding
description:
  Enoyl-[acyl-carrier-protein] reductase, mitochondrial; 2-enoyl thioester reductase; member of the medium chain dehydrogenase/reductase family; localized to mitochondria, where it has a probable role in fatty acid synthesis; human MECR functionally complements the respiratory growth defect of the null mutant.


ensembl_gene_id: YBR027C
symbol: YBR027C
gene_biotype: protein_coding
description:
  Uncharacterized protein YBR027C; Putative protein of unknown function; conserved among S. cerevisiae strains; YBR027C is not an essential gene.


ensembl_gene_id: YBR028C
symbol: YPK3
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase YPK3; AGC kinase; phosphorylated by cAMP-dependent protein kinase (PKA) in a TORC1-dependent manner; directly phosphorylated by TORC1; phosphorylates ribosomal protein Rps6a/b (S6), in a TORC-dependent manner; undergoes autophosphorylation.


ensembl_gene_id: YBR029C
symbol: CDS1
gene_biotype: protein_coding
description:
  Phosphatidate cytidylyltransferase (CDP-diglyceride synthetase); an enzyme that catalyzes that conversion of CTP + phosphate into diphosphate + CDP-diaclglyerol, a critical step in the synthesis of all major yeast phospholipids; human homolog CDS1 can complement yeast cds1 null mutant.


ensembl_gene_id: YBR030W
symbol: RKM3
gene_biotype: protein_coding
description:
  Ribosomal lysine methyltransferase; specific for monomethylation of Rpl42ap and Rpl42bp (lysine 40); nuclear SET domain containing protein; relocalizes to the cytosol in response to hypoxia.


ensembl_gene_id: YBR031W
symbol: RPL4A
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L4A; N-terminally acetylated; homologous to mammalian ribosomal protein L4 and bacterial L4; RPL4A has a paralog, RPL4B, that arose from the whole genome duplication.


ensembl_gene_id: YBR032W
symbol: YBR032W
gene_biotype: protein_coding
description:
  Uncharacterized protein YBR032W; Putative protein of unknown function; conserved among S. cerevisiae strains; YBR032W is not an essential gene.


ensembl_gene_id: YBR033W
symbol: EDS1
gene_biotype: protein_coding
description:
  Transcriptional regulatory protein EDS1; Putative zinc cluster protein, predicted to be a transcription factor; not an essential gene; EDS1 has a paralog, RGT1, that arose from the whole genome duplication; Belongs to the EDS1/RGT1 family.


ensembl_gene_id: YBR034C
symbol: HMT1
gene_biotype: protein_coding
description:
  Protein arginine N-methyltransferase 1; Nuclear SAM-dependent mono- and asymmetric methyltransferase; modifies hnRNPs, including Npl3p and Hrp1p, affecting their activity and nuclear export; methylates U1 snRNP protein Snp1p, ribosomal protein Rps2p, and histones H3 and H4; interacts genetically with genes encoding components of Rpd3(L) and this interaction is important for Rpd3 recruitment to the subtelomeric region.


ensembl_gene_id: YBR035C
symbol: PDX3
gene_biotype: protein_coding
description:
  Pyridoxine (pyridoxamine) phosphate oxidase; has homologs in E. coli and Myxococcus xanthus; transcription is under the general control of nitrogen metabolism; Belongs to the pyridoxamine 5'-phosphate oxidase family.


ensembl_gene_id: YBR036C
symbol: CSG2
gene_biotype: protein_coding
description:
  Mannosyl phosphorylinositol ceramide synthase regulatory protein CSG2; Endoplasmic reticulum membrane protein; required for mannosylation of inositolphosphorylceramide and for growth at high calcium concentrations; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YBR037C
symbol: SCO1
gene_biotype: protein_coding
description:
  Copper-binding protein of mitochondrial inner membrane; required for cytochrome c oxidase activity and respiration; may function to deliver copper to cytochrome c oxidase; similar to thioredoxins; SCO1 has a paralog, SCO2, that arose from the whole genome duplication.


ensembl_gene_id: YBR038W
symbol: CHS2
gene_biotype: protein_coding
description:
  Chitin synthase II; catalyzes transfer of N-acetylglucosamine (GlcNAc) to chitin upon activation of zymogenic form; required for chitin synthesis in the primary septum during cytokinesis; localization regulated by Cdk1p during mitosis; phosphorylation by Dbf2p kinase regulates its dynamics and chitin synthesis during cytokinesis.


ensembl_gene_id: YBR039W
symbol: ATP3
gene_biotype: protein_coding
description:
  Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis.


ensembl_gene_id: YBR040W
symbol: FIG1
gene_biotype: protein_coding
description:
  Factor-induced gene 1 protein; Integral membrane protein required for efficient mating; may participate in or regulate the low affinity Ca2+ influx system, which affects intracellular signaling and cell-cell fusion during mating.


ensembl_gene_id: YBR041W
symbol: FAT1
gene_biotype: protein_coding
description:
  Very long chain fatty acyl-CoA synthetase and fatty acid transporter; activates imported fatty acids with a preference for very long lengths (C20-C26); has a separate function in the transport of long chain fatty acids.


ensembl_gene_id: YBR042C
symbol: CST26
gene_biotype: protein_coding
description:
  Uncharacterized acyltransferase CST26; Acyltransferase; enzyme mainly responsible for the introduction of saturated very long chain fatty acids into neo-synthesized molecules of phosphatidylinositol; required for incorporation of stearic acid into phosphatidylinositol; affects chromosome stability when overexpressed; CST26 has a paralog, YDR018C, that arose from the whole genome duplication.


ensembl_gene_id: YBR043C
symbol: QDR3
gene_biotype: protein_coding
description:
  Quinidine resistance protein 3; Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; has a role in polyamine homeostasis; involved in spore wall asembly; sequence similarity to DTR1 and QDR1, and the triple mutant dtr1 qdr1 qdr3 exhibits reduced dityrosine fluorescence relative to the single mutants; expression is upregulated under polyamine stress; required for resistance to quinidine, barban, cisplatin, and bleomycin.


ensembl_gene_id: YBR044C
symbol: TCM62
gene_biotype: protein_coding
description:
  Mitochondrial chaperone TCM62; Protein involved in assembly of the succinate dehydrogenase complex; mitochondrial; putative chaperone.


ensembl_gene_id: YBR045C
symbol: GIP1
gene_biotype: protein_coding
description:
  GLC7-interacting protein 1; Meiosis-specific regulatory subunit of the Glc7p protein phosphatase; regulates spore wall formation and septin organization, required for expression of some late meiotic genes and for normal localization of Glc7p.


ensembl_gene_id: YBR046C
symbol: ZTA1
gene_biotype: protein_coding
description:
  Probable quinone oxidoreductase; NADPH-dependent quinone reductase; GFP-tagged protein localizes to the cytoplasm and nucleus; has similarity to E. coli quinone oxidoreductase and to human zeta-crystallin.


ensembl_gene_id: YBR047W
symbol: FMP23
gene_biotype: protein_coding
description:
  Protein FMP23, mitochondrial; Putative protein of unknown function; proposed to be involved in iron or copper homeostasis; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies.


ensembl_gene_id: YBR048W
symbol: RPS11B
gene_biotype: protein_coding
description:
  Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S11 and bacterial S17; RPS11B has a paralog, RPS11A, that arose from the whole genome duplication.


ensembl_gene_id: YBR049C
symbol: REB1
gene_biotype: protein_coding
description:
  DNA-binding protein REB1; RNA polymerase I enhancer binding protein; DNA binding protein that binds to genes transcribed by both RNA polymerase I and RNA polymerase II; required for termination of RNA polymerase I transcription; Reb1p bound to DNA acts to block RNA polymerase II readthrough transcription.


ensembl_gene_id: YBR050C
symbol: REG2
gene_biotype: protein_coding
description:
  Protein REG2; Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease; REG2 has a paralog, REG1, that arose from the whole genome duplication.


ensembl_gene_id: YBR051W
symbol: YBR051W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YBR051W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the REG2/YBR050C regulatory subunit of the Glc7p type-1 protein phosphatase.


ensembl_gene_id: YBR052C
symbol: RFS1
gene_biotype: protein_coding
description:
  Protein of unknown function; member of a flavodoxin-like fold protein family that includes Pst2p and Ycp4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; RFS1 has a paralog, PST2, that arose from the whole genome duplication.


ensembl_gene_id: YBR053C
symbol: YBR053C
gene_biotype: protein_coding
description:
  Uncharacterized protein YBR053C; Putative protein of unknown function; induced by cell wall perturbation.


ensembl_gene_id: YBR054W
symbol: YRO2
gene_biotype: protein_coding
description:
  Protein with a putative role in response to acid stress; null mutant is sensitive to acetic acid; transcription is regulated by Haa1p and induced in the presence of acetic acid; protein observed in plasma membrane foci in the presence of acetic acid; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; Belongs to the archaeal/bacterial/fungal opsin family.


ensembl_gene_id: YBR056C-B
symbol: YBR056C-B
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YBR056C-B; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps the dubious ORF YBR056W-A.


ensembl_gene_id: YBR056W
symbol: YBR056W
gene_biotype: protein_coding
description:
  Uncharacterized glycosyl hydrolase YBR056W; Putative glycoside hydrolase of the mitochondrial intermembrane space.


ensembl_gene_id: YBR056W-A
symbol: YBR056W-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YBR056W-A; Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps dubious ORF YBR056C-B; YBR056W-A has a paralog, YDR034W-B, that arose from the whole genome duplication.


ensembl_gene_id: YBR057C
symbol: MUM2
gene_biotype: protein_coding
description:
  Protein essential for meiotic DNA replication and sporulation; cytoplasmic protein; subunit of the MIS complex which controls mRNA methylation during during the induction of sporulation; also interacts with Orc2p, which is a component of the origin recognition complex; Belongs to the fl(2)d family.


ensembl_gene_id: YBR058C
symbol: UBP14
gene_biotype: protein_coding
description:
  Ubiquitin carboxyl-terminal hydrolase 14; Ubiquitin-specific protease; specifically disassembles unanchored ubiquitin chains; involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; similar to human isopeptidase T; Belongs to the peptidase C19 family.


ensembl_gene_id: YBR058C-A
symbol: TSC3
gene_biotype: protein_coding
description:
  Protein that stimulates the activity of serine palmitoyltransferase;  involved in sphingolipid biosynthesis; Lcb1p and Lcb2p are the two components of serine palmitoyltransferase.


ensembl_gene_id: YBR059C
symbol: AKL1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase AKL1; Ser-Thr protein kinase; member (with Ark1p and Prk1p) of the Ark kinase family; involved in endocytosis and actin cytoskeleton organization.


ensembl_gene_id: YBR060C
symbol: ORC2
gene_biotype: protein_coding
description:
  Subunit of the origin recognition complex (ORC); ORC directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; interacts with Spp1p and with trimethylated histone H3; phosphorylated by Cdc28p.


ensembl_gene_id: YBR061C
symbol: TRM7
gene_biotype: protein_coding
description:
  2'-O-ribose methyltransferase; methylates the 2'-O-ribose of tRNA-Phe, tRNA-Trp, and tRNA-Leu at positions C32 and N34 of tRNA anticodon loop; crucial biological role likely modification of tRNA-Phe; interacts with Trm732p and Rtt10p in 2'-O-methylation of C32 and N34 substrate tRNAs, respectively; yeast null mutant can be functionally complemented by human FTSJ1, mutations in which have been implicated in nonsyndromic X-linked intellectual disability (NSXLID); Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.


ensembl_gene_id: YBR062C
symbol: YBR062C
gene_biotype: protein_coding
description:
  Uncharacterized RING finger protein YBR062C; Protein of unknown function that interacts with Msb2p; may play a role in activation of the filamentous growth pathway.


ensembl_gene_id: YBR064W
symbol: YBR064W
gene_biotype: protein_coding
description:
  Putative uncharacterized membrane protein YBR064W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YBR063C.


ensembl_gene_id: YBR065C
symbol: ECM2
gene_biotype: protein_coding
description:
  Pre-mRNA-splicing factor SLT11; Pre-mRNA splicing factor; facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome, function may be regulated by Slu7p; Belongs to the SLT11 family.


ensembl_gene_id: YBR066C
symbol: NRG2
gene_biotype: protein_coding
description:
  Probable transcriptional regulator NRG2; Transcriptional repressor; mediates glucose repression and negatively regulates filamentous growth; activated in stochastic pulses of nuclear localization in response to low glucose.


ensembl_gene_id: YBR067C
symbol: TIP1
gene_biotype: protein_coding
description:
  Temperature shock-inducible protein 1; Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins.


ensembl_gene_id: YBR068C
symbol: BAP2
gene_biotype: protein_coding
description:
  Leu/Val/Ile amino-acid permease; High-affinity leucine permease; functions as a branched-chain amino acid permease involved in uptake of leucine, isoleucine and valine; contains 12 predicted transmembrane domains; BAP2 has a paralog, BAP3, that arose from the whole genome duplication; Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.


ensembl_gene_id: YBR069C
symbol: TAT1
gene_biotype: protein_coding
description:
  Valine/tyrosine/tryptophan amino-acid permease 1; Amino acid transporter for valine, leucine, isoleucine, and tyrosine; low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YBR070C
symbol: ALG14
gene_biotype: protein_coding
description:
  UDP-N-acetylglucosamine transferase subunit ALG14; Component of UDP-GlcNAc transferase; required for second step of dolichyl-linked oligosaccharide synthesis; anchors catalytic subunit Alg13p to ER membrane; similar to bacterial and human glycosyltransferases; both human homologs ALG13 and ALG14 are required to complement yeast alg14 mutant.


ensembl_gene_id: YBR071W
symbol: YBR071W
gene_biotype: protein_coding
description:
  Uncharacterized protein YBR071W; Protein of unknown function found in the cytoplasm and bud neck; mRNA expression may be regulated by the cell cycle and/or cell wall stress; overexpression of YBR071W affects endocytic protein trafficking.


ensembl_gene_id: YBR072C-A
symbol: YBR072C-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YBR072C-A; Putative protein of unknown function; identified by fungal homology and RT-PCR.


ensembl_gene_id: YBR072W
symbol: HSP26
gene_biotype: protein_coding
description:
  Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; long-lived protein that is preferentially retained in mother cells and forms cytoplasmic foci; oligomer activation requires heat-induced conformational change; also has mRNA binding activity.


ensembl_gene_id: YBR073W
symbol: RDH54
gene_biotype: protein_coding
description:
  DNA-dependent ATPase; DNA recombination/repair translocase, supercoils DNA and promotes DNA strand opening; stimulates strand exchange by modifying dsDNA topology; involved in recombinational repair of DNA double-strand breaks (DSBs) during mitosis and meiosis; phosphorylated in Mec1p-, Rad53p-dependent way in response to one DSB; contributes to remodelling of nucleosomes; proposed to be involved in crossover interference; interacts with Dmc1p; stimulates Dmc1p and Rad51p.


ensembl_gene_id: YBR074W
symbol: PFF1
gene_biotype: protein_coding
description:
  Multi-spanning vacuolar membrane protease; glycosylated transmembrane protein bearing homology to the M28 family of metalloproteases; has a lumenal-facing protease domain; proposed role in vacuole physiology.


ensembl_gene_id: YBR076C-A
symbol: YBR076C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YBR076C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified gene ECM8; identified by fungal homology and RT-PCR.


ensembl_gene_id: YBR077C
symbol: SLM4
gene_biotype: protein_coding
description:
  Protein SLM4; Component of the EGO and GSE complexes; essential for integrity and function of EGO; EGO is involved in the regulation of microautophagy and GSE is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4.


ensembl_gene_id: YBR078W
symbol: ECM33
gene_biotype: protein_coding
description:
  Cell wall protein ECM33; GPI-anchored protein of unknown function; possible role in apical bud growth; GPI-anchoring on the plasma membrane crucial to function; phosphorylated in mitochondria; similar to Sps2p; ECM33 has a paralog, PST1, that arose from the whole genome duplication.


ensembl_gene_id: YBR079C
symbol: RPG1
gene_biotype: protein_coding
description:
  eIF3a subunit of the eukaryotic translation initiation factor 3 (eIF3); subunit of the core complex of eIF3; essential for translation; part of a Prt1p-Rpg1p-Nip1p subcomplex that stimulates binding of mRNA and tRNA(i)Met to ribosomes; involved in translation reinitiation; eIF3 is also involved in programmed stop codon readthrough.


ensembl_gene_id: YBR080C
symbol: SEC18
gene_biotype: protein_coding
description:
  Vesicular-fusion protein SEC18; AAA ATPase and SNARE disassembly chaperone; required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, autophagy, and protein secretion; releases Sec17p from SNAP complexes; has similarity to mammalian N-ethylmaleimide-sensitive factor (NSF).


ensembl_gene_id: YBR081C
symbol: SPT7
gene_biotype: protein_coding
description:
  Transcriptional activator SPT7; Subunit of the SAGA transcriptional regulatory complex; involved in proper assembly of the complex; also present as a C-terminally truncated form in the SLIK/SALSA transcriptional regulatory complex.


ensembl_gene_id: YBR082C
symbol: UBC4
gene_biotype: protein_coding
description:
  Ubiquitin-conjugating enzyme (E2); key E2 partner with Ubc1p for the anaphase-promoting complex (APC); mediates degradation of abnormal or excess proteins, including calmodulin and histone H3; regulates levels of DNA Polymerase-{alpha} to promote efficient and accurate DNA replication; interacts with many SCF ubiquitin protein ligases; component of the cellular stress response; UBC4 has a paralog, UBC5, that arose from the whole genome duplication.


ensembl_gene_id: YBR083W
symbol: TEC1
gene_biotype: protein_coding
description:
  Transcription factor targeting filamentation genes and Ty1 expression; Ste12p activation of most filamentation gene promoters depends on Tec1p and Tec1p transcriptional activity is dependent on its association with Ste12p; binds to TCS elements upstream of filamentation genes, which are regulated by Tec1p/Ste12p/Dig1p complex; competes with Dig2p for binding to Ste12p/Dig1p; positive regulator of chronological life span; TEA/ATTS DNA-binding domain family member; Belongs to the TEC1 family.


ensembl_gene_id: YBR084C-A
symbol: RPL19A
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L19A; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal; homologous to mammalian ribosomal protein L19, no bacterial homolog; RPL19A has a paralog, RPL19B, that arose from the whole genome duplication.


ensembl_gene_id: YBR084W
symbol: MIS1
gene_biotype: protein_coding
description:
  C-1-tetrahydrofolate synthase, mitochondrial; Mitochondrial C1-tetrahydrofolate synthase; involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase.


ensembl_gene_id: YBR085C-A
symbol: YBR085C-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YBR085C-A; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YBR085W
symbol: AAC3
gene_biotype: protein_coding
description:
  ADP,ATP carrier protein 3; Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Aac1p; has roles in maintenance of viability and in respiration; AAC3 has a paralog, PET9, that arose from the whole genome duplication; Belongs to the mitochondrial carrier (TC 2.A.29) family.


ensembl_gene_id: YBR086C
symbol: IST2
gene_biotype: protein_coding
description:
  Increased sodium tolerance protein 2; Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localizes to the mother cell in small-budded cells and to the bud in medium- and large-budded cells; mRNA is transported to the bud tip by an actomyosin-driven process.


ensembl_gene_id: YBR087W
symbol: RFC5
gene_biotype: protein_coding
description:
  Subunit of heteropentameric Replication factor C (RF-C); RF-C is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon.


ensembl_gene_id: YBR088C
symbol: POL30
gene_biotype: protein_coding
description:
  Proliferating cell nuclear antigen (PCNA); functions as the sliding replication clamp for DNA polymerase delta; may function as a docking site for other proteins required for mitotic and meiotic chromosomal DNA replication and for DNA repair; PCNA ubiquitination at K164 plays a crucial role during Okazaki fragment processing.


ensembl_gene_id: YBR089C-A
symbol: NHP6B
gene_biotype: protein_coding
description:
  Non-histone chromosomal protein 6B; High-mobility group (HMG) protein; binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to the chromosomes; functionally redundant with Nhp6Ap; required for transcriptional initiation fidelity of some tRNA genes; homologous to mammalian HMGB1 and HMGB2; NHP6B has a paralog, NHP6A, that arose from the whole genome duplication.


ensembl_gene_id: YBR089W
symbol: YBR089W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YBR089W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene POL30.


ensembl_gene_id: YBR090C
symbol: YBR090C
gene_biotype: protein_coding
description:
  Uncharacterized protein YBR090C; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus.


ensembl_gene_id: YBR091C
symbol: TIM12
gene_biotype: protein_coding
description:
  Mitochondrial import inner membrane translocase subunit TIM12; Essential protein of the inner mitochondrial membrane; peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins.


ensembl_gene_id: YBR092C
symbol: PHO3
gene_biotype: protein_coding
description:
  Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin.


ensembl_gene_id: YBR093C
symbol: PHO5
gene_biotype: protein_coding
description:
  Repressible acid phosphatase; 1 of 3 repressible acid phosphatases that also mediates extracellular nucleotide-derived phosphate hydrolysis; secretory pathway derived cell surface glycoprotein; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2; Belongs to the histidine acid phosphatase family.


ensembl_gene_id: YBR094W
symbol: PBY1
gene_biotype: protein_coding
description:
  Probable tubulin--tyrosine ligase PBY1; Putative tubulin tyrosine ligase associated with P-bodies; may have a role in mRNA metabolism; yeast knockout collection strain identified as a pby1 null mutant is actually wild-type for PBY1 and deleted for mms4; Belongs to the tubulin--tyrosine ligase family.


ensembl_gene_id: YBR095C
symbol: RXT2
gene_biotype: protein_coding
description:
  Transcriptional regulatory protein RXT2; Component of the histone deacetylase Rpd3L complex; possibly involved in cell fusion and invasive growth; relocalizes to the cytosol in response to hypoxia.


ensembl_gene_id: YBR096W
symbol: YBR096W
gene_biotype: protein_coding
description:
  Uncharacterized protein YBR096W; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER.


ensembl_gene_id: YBR097W
symbol: VPS15
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase VPS15; Serine/threonine protein kinase involved in vacuolar protein sorting; functions as a membrane-associated complex with Vps34p; active form recruits Vps34p to the Golgi membrane; interacts with the GDP-bound form of Gpa1p; myristoylated; a fraction is localized, with Vps34p, to nuclear pores at nucleus-vacuole junctions and may facilitate transcription elongation for genes positioned at the nuclear periphery.


ensembl_gene_id: YBR098W
symbol: MMS4
gene_biotype: protein_coding
description:
  Subunit of structure-specific Mms4p-Mus81p endonuclease; cleaves branched DNA; involved in recombination, DNA repair, and joint molecule formation/resolution during meiotic recombination; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdc5p during mitotic cell cycle activates the function of Mms4p-Mus81p.


ensembl_gene_id: YBR099C
symbol: YBR099C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YBR099C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified gene MMS4.


ensembl_gene_id: YBR101C
symbol: FES1
gene_biotype: protein_coding
description:
  Hsp70 (Ssa1p) nucleotide exchange factor; required for the release of misfolded proteins from the Hsp70 system to the Ub-proteasome machinery for destruction; cytosolic homolog of Sil1p, which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YBR102C
symbol: EXO84
gene_biotype: protein_coding
description:
  Exocyst complex component EXO84; Exocyst subunit with dual roles in exocytosis and spliceosome assembly; subunit of the the exocyst complex which mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane (PM) prior to SNARE-mediated fusion; required for exocyst assembly and targeting the complex to specific sites on the bud tip PM; associates the U1 snRNP; role in pre-mRNA splicing and prespliceosome formation; possible Cdc28 substrate; Belongs to the EXO84 family.


ensembl_gene_id: YBR103C-A
symbol: YBR103C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YBR103C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by homology to related yeast.


ensembl_gene_id: YBR103W
symbol: SIF2
gene_biotype: protein_coding
description:
  SIR4-interacting protein SIF2; WD40 repeat-containing subunit of Set3C histone deacetylase complex; complex represses early/middle sporulation genes; antagonizes telomeric silencing; binds specifically to the Sir4p N-terminus.


ensembl_gene_id: YBR104W
symbol: YMC2
gene_biotype: protein_coding
description:
  Carrier protein YMC2, mitochondrial; Putative mitochondrial inner membrane transporter; proposed role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; YMC2 has a paralog, YMC1, that arose from the whole genome duplication.


ensembl_gene_id: YBR105C
symbol: VID24
gene_biotype: protein_coding
description:
  Vacuolar import and degradation protein 24; GID Complex regulatory subunit; binds GID Complex in response to glucose through interactions with complex member Vid28p; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; promotes proteasome-dependent catabolite degradation of FBPase; peripheral membrane protein located at Vid (vacuole import and degradation) vesicles; Belongs to the GID4/VID24 family.


ensembl_gene_id: YBR106W
symbol: PHO88
gene_biotype: protein_coding
description:
  Protein involved in SRP-independent targeting of substrates to the ER; component of an alternative ER targeting pathway that has partial functional redundancy with the GET pathway; preference for substrates with downstream transmembrane domains; interacts with Snd1p, Env10p/Snd2p, and Sec61p-translocon subunits; can compensate for loss of SRP; role in phosphate transport, interacting with pho88, and in the maturation of secretory proteins.


ensembl_gene_id: YBR107C
symbol: IML3
gene_biotype: protein_coding
description:
  Inner kinetochore subunit IML3; Outer kinetochore protein and component of the Ctf19 complex; involved in the establishment of pericentromeric cohesion during mitosis; prevents non-disjunction of sister chromatids during meiosis II; forms a stable complex with Chl4p; required for localization of Sgo1p to pericentric sites during meiosis I; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-L and fission yeast fta1; Belongs to the CENP-L/IML3 family.


ensembl_gene_id: YBR108W
symbol: AIM3
gene_biotype: protein_coding
description:
  Altered inheritance of mitochondria protein 3; Protein that inhibits barbed-end actin filament elongation; interacts with Rvs167p; null mutant is viable and displays elevated frequency of mitochondrial genome loss; Belongs to the AIM3 family.


ensembl_gene_id: YBR109C
symbol: CMD1
gene_biotype: protein_coding
description:
  Calmodulin; Ca2+ binding protein that regulates Ca2+ independent processes (mitosis, bud growth, actin organization, endocytosis, etc.) and Ca2+ dependent processes (stress-activated pathways), targets include Nuf1p, Myo2p and calcineurin; binds to the Hog1p MAPK in response to hyperosmotic stress; potentiates membrane tubulation and constriction mediated by the Rvs161p-Rvs167p complex; human CALM1 or CALM2 functionally complement repression induced inviability.


ensembl_gene_id: YBR110W
symbol: ALG1
gene_biotype: protein_coding
description:
  Chitobiosyldiphosphodolichol beta-mannosyltransferase; Mannosyltransferase; involved in asparagine-linked glycosylation in the endoplasmic reticulum (ER); essential for viability; human homolog ALG1 complements yeast null mutant.


ensembl_gene_id: YBR111C
symbol: YSA1
gene_biotype: protein_coding
description:
  Nudix hydrolase family member with ADP-ribose pyrophosphatase activity; shown to metabolize O-acetyl-ADP-ribose to AMP and acetylated ribose 5'-phosphate; Belongs to the Nudix hydrolase family. NudF subfamily.


ensembl_gene_id: YBR111W-A
symbol: SUS1
gene_biotype: protein_coding
description:
  Transcription and mRNA export factor SUS1; Component of both the SAGA histone acetylase and TREX-2 complexes; interacts with RNA polymerase II; involved in mRNA export coupled transcription activation and elongation; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP.


ensembl_gene_id: YBR112C
symbol: CYC8
gene_biotype: protein_coding
description:
  General transcriptional co-repressor; acts together with Tup1p; also acts as part of a transcriptional co-activator complex that recruits the SWI/SNF and SAGA complexes to promoters; can form the prion [OCT+].


ensembl_gene_id: YBR113W
symbol: YBR113W
gene_biotype: protein_coding
description:
  Putative uncharacterized membrane protein YBR113W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CYC8.


ensembl_gene_id: YBR114W
symbol: RAD16
gene_biotype: protein_coding
description:
  Nucleotide excision repair (NER) protein; binds damaged DNA during NER; binds DNA in an ATP-dependent manner (with Rad7p) during NER; required for NER of non-transcribed chromatin; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex.


ensembl_gene_id: YBR115C
symbol: LYS2
gene_biotype: protein_coding
description:
  Alpha aminoadipate reductase; catalyzes the reduction of alpha-aminoadipate to alpha-aminoadipate 6-semialdehyde, which is the fifth step in biosynthesis of lysine; activation requires posttranslational phosphopantetheinylation by Lys5p; Belongs to the ATP-dependent AMP-binding enzyme family.


ensembl_gene_id: YBR116C
symbol: YBR116C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YBR116C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TKL2.


ensembl_gene_id: YBR117C
symbol: TKL2
gene_biotype: protein_coding
description:
  Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; TKL2 has a paralog, TKL1, that arose from the whole genome duplication.


ensembl_gene_id: YBR118W
symbol: TEF2
gene_biotype: protein_coding
description:
  Translational elongation factor EF-1 alpha; in the GTP-bound active form, binds to and delivers aminoacylated tRNA to the A-site of ribosomes for elongation of nascent polypeptides; associates with vacuolar Rho1p GTPase; TEF2-RFP levels increase during replicative aging; may also have a role in tRNA re-export from the nucleus; TEF2 has a paralog, TEF1, that arose from the whole genome duplication.


ensembl_gene_id: YBR119W
symbol: MUD1
gene_biotype: protein_coding
description:
  U1 snRNP A protein; homolog of human U1-A; involved in nuclear mRNA splicing; Belongs to the RRM U1 A/B'' family.


ensembl_gene_id: YBR120C
symbol: CBP6
gene_biotype: protein_coding
description:
  Cytochrome B pre-mRNA-processing protein 6; Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex; Cbp3p-Cbp6p complex is sequestered if assembly of Complex III is blocked, downregulating COB mRNA translation.


ensembl_gene_id: YBR121C
symbol: GRS1
gene_biotype: protein_coding
description:
  Glycine--tRNA ligase 1, mitochondrial; Cytoplasmic and mitochondrial glycyl-tRNA synthase; ligates glycine to the cognate anticodon-bearing tRNA; transcription termination factor that may interact with the 3'-end of pre-mRNA to promote 3'-end formation; GRS1 has a paralog, GRS2, that arose from the whole genome duplication; human homolog GARS implicated in Charcot-Marie-Tooth disease, can complement yeast null mutant; Belongs to the class-II aminoacyl-tRNA synthetase family.


ensembl_gene_id: YBR121C-A
symbol: YBR121C-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YBR121C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely contained within the verified gene GRS1; identified by expression profiling and mass spectrometry.


ensembl_gene_id: YBR122C
symbol: MRPL36
gene_biotype: protein_coding
description:
  Mitochondrial ribosomal protein of the large subunit; overproduction suppresses mutations in the COX2 leader peptide-encoding region.


ensembl_gene_id: YBR123C
symbol: TFC1
gene_biotype: protein_coding
description:
  Subunit of RNA polymerase III transcription initiation factor complex; one of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA globular domain of TFIIIC that binds DNA at the BoxA promoter sites of tRNA and similar genes; human homolog is TFIIIC-63.


ensembl_gene_id: YBR125C
symbol: PTC4
gene_biotype: protein_coding
description:
  Cytoplasmic type 2C protein phosphatase (PP2C); identified as a high-copy number suppressor of cnb1 mpk1 synthetic lethality; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity.


ensembl_gene_id: YBR126C
symbol: TPS1
gene_biotype: protein_coding
description:
  Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 56 kDa subunit; Synthase subunit of trehalose-6-P synthase/phosphatase complex; synthesizes the storage carbohydrate trehalose, which is critically important for survival of long-term desiccation; also found in a monomeric form; expression is induced by the stress response and repressed by the Ras-cAMP pathway; protein abundance increases in response to DNA replication stress and in response to prolonged exposure to boric acid.


ensembl_gene_id: YBR126W-A
symbol: MEO1
gene_biotype: protein_coding
description:
  Uncharacterized protein YBR126W-A; Putative protein of unknown function; identified by gene-trapping, microarray analysis, and genome-wide homology searches; mRNA identified as translated by ribosome profiling data; SWAT-GFP, seamless-GFP and mCherry fusion proteins localize to the endoplasmic reticulum; partially overlaps the dubious ORF YBR126W-B.


ensembl_gene_id: YBR126W-B
symbol: YBR126W-B
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YBR126W-B; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YBR126W-A; identified by SAGE.


ensembl_gene_id: YBR127C
symbol: VMA2
gene_biotype: protein_coding
description:
  V-type proton ATPase subunit B; Subunit B of V1 peripheral membrane domain of vacuolar H+-ATPase; electrogenic proton pump found throughout the endomembrane system; contains nucleotide binding sites; also detected in the cytoplasm; protein abundance increases in response to DNA replication stress; human homolog ATP6V1B1, implicated in autosomal-recessive distal renal tubular acidosis (RTA) with sensorineural deafness, complements yeast null mutant; Belongs to the ATPase alpha/beta chains family.


ensembl_gene_id: YBR128C
symbol: ATG14
gene_biotype: protein_coding
description:
  Autophagy-related protein 14; Autophagy-specific subunit of phosphatidylinositol 3-kinase complex I; Atg14p targets complex I to the phagophore assembly site (PAS); required for localizing additional ATG proteins to the PAS; required for overflow degradation of misfolded proteins when ERAD is saturated; homolog of human Barkor; other members are Vps34, Vps15, and Vps30p.


ensembl_gene_id: YBR129C
symbol: OPY1
gene_biotype: protein_coding
description:
  Protein of unknown function; overproduction blocks cell cycle arrest in the presence of mating pheromone; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies.


ensembl_gene_id: YBR130C
symbol: SHE3
gene_biotype: protein_coding
description:
  SWI5-dependent HO expression protein 3; Protein adaptor between Myo4p and the She2p-mRNA complex; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud; also required for cortical ER inheritance.


ensembl_gene_id: YBR131C-A
symbol: YBR131C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YBR131C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YBR131W; identified by gene-trapping, microarray analysis, and genome-wide homology searches.


ensembl_gene_id: YBR131W
symbol: CCZ1
gene_biotype: protein_coding
description:
  Vacuolar fusion protein CCZ1; Subunit of a heterodimeric guanine nucleotide exchange factor (GEF); subunit of the Mon1-Ccz1 GEF complex, which stimulates nucleotide exchange and activation of Ypt7p, a Rab family GTPase involved in membrane tethering and fusion events at the late endosome and vacuole; GEF activity is stimulated by membrane association and anionic phospholipids; involved in localizing Ypt7p to the vacuolar membrane; required for macroautophagy, the CVT pathway and mitophagy.


ensembl_gene_id: YBR132C
symbol: AGP2
gene_biotype: protein_coding
description:
  General amino acid permease AGP2; Plasma membrane regulator of polyamine and carnitine transport; has similarity to transporters but lacks transport activity; may act as a sensor that transduces environmental signals; has a positive or negative regulatory effect on transcription of many transporter genes.


ensembl_gene_id: YBR133C
symbol: HSL7
gene_biotype: protein_coding
description:
  Protein arginine N-methyltransferase; exhibits septin and Hsl1p-dependent localization to the bud neck in budded cells and periodic Hsl1p-dependent phosphorylation; required with Hsl1p, and Elm1p for the mother-bud neck recruitment, phosphorylation, and degradation of Swe1p; interacts directly with Swe1p; relocalizes away from bud neck upon DNA replication stress; human homolog PRMT5 can complement yeast hsl7 mutant.


ensembl_gene_id: YBR134W
symbol: YBR134W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YBR134W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YBR135W
symbol: CKS1
gene_biotype: protein_coding
description:
  Cyclin-dependent protein kinase regulatory subunit and adaptor; interacts with Cdc28p (aka Cdk1p); required for G1/S and G2/M phase transitions and budding; mediates phosphorylation and degradation of Sic1p; modulates proteolysis of M-phase targets through interactions with the proteasome; role in transcriptional regulation, recruiting proteasomal subunits to target gene promoters; human homologs CKS1B and CKS2 can each complement yeast cks1 null mutant.


ensembl_gene_id: YBR136W
symbol: MEC1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase MEC1; Genome integrity checkpoint protein and PI kinase superfamily member; Mec1p and Dun1p function in same pathway to regulate dNTP pools and telomere length; signal transducer required for cell cycle arrest and transcriptional responses to damaged or unreplicated DNA; facilitates replication fork progression and regulates P-body formation under replication stress; promotes interhomolog recombination by phosphorylating Hop1p; associates with shortened, dysfunctional telomeres.


ensembl_gene_id: YBR137W
symbol: YBR137W
gene_biotype: protein_coding
description:
  UPF0303 protein YBR137W; Protein with a role in ER delivery of tail-anchored membrane proteins; interacts with Sgt2p; binds to the TRC complex, which inserts proteins into the ER membrane; interacts with Msn5p karyopherin; YBR137W is not an essential gene; Belongs to the UPF0303 family.


ensembl_gene_id: YBR138C
symbol: YBR138C
gene_biotype: protein_coding
description:
  Uncharacterized protein YBR138C; Cytoplasmic protein of unknown function; APCC(Cdh1) substrate; potentially phosphorylated by Cdc28p; YBR138C is not an essential gene.


ensembl_gene_id: YBR139W
symbol: YBR139W
gene_biotype: protein_coding
description:
  Putative serine type carboxypeptidase; role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner.


ensembl_gene_id: YBR140C
symbol: IRA1
gene_biotype: protein_coding
description:
  Inhibitory regulator protein IRA1; GTPase-activating protein; negatively regulates RAS by converting it from GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, mediates membrane association of adenylate cyclase; mutations cause catalase T deficiency, defective glycogen synthesis and defective trehalose accumulation; IRA1 has a paralog, IRA2, that arose from the whole genome duplication; defects in human homolog NF1 are associated with neurofibromatosis.


ensembl_gene_id: YBR141C
symbol: BMT2
gene_biotype: protein_coding
description:
  25S rRNA (adenine(2142)-N(1))-methyltransferase; Nucleolar S-adenosylmethionine-dependent rRNA methyltransferase; methylates adenine (m1A) of the large subunit (LSU) rRNA at position 2142; belongs to Rossmann fold superfamily; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YBR141C is not an essential gene.


ensembl_gene_id: YBR141W-A
symbol: YBR141W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YBR141W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the uncharacterized ORF YBR141C; identified by gene-trapping, microarray analysis, and genome-wide homology searching.


ensembl_gene_id: YBR142W
symbol: MAK5
gene_biotype: protein_coding
description:
  Essential nucleolar protein; putative DEAD-box RNA helicase required for maintenance of M1 dsRNA virus; involved in biogenesis of large (60S) ribosomal subunits; Belongs to the DEAD box helicase family. DDX24/MAK5 subfamily.


ensembl_gene_id: YBR143C
symbol: SUP45
gene_biotype: protein_coding
description:
  Polypeptide release factor (eRF1) in translation termination; mutant form acts as a recessive omnipotent suppressor; methylated by Mtq2p-Trm112p in ternary complex eRF1-eRF3-GTP; mutation of methylation site confers resistance to zymocin; has a role in cytokinesis through interaction with Mlc1p.


ensembl_gene_id: YBR144C
symbol: YBR144C
gene_biotype: protein_coding
description:
  Uncharacterized protein YBR144C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; YBR144C is not an essential gene.


ensembl_gene_id: YBR145W
symbol: ADH5
gene_biotype: protein_coding
description:
  Alcohol dehydrogenase isoenzyme V; involved in ethanol production; ADH5 has a paralog, ADH1, that arose from the whole genome duplication; Belongs to the zinc-containing alcohol dehydrogenase family.


ensembl_gene_id: YBR147W
symbol: RTC2
gene_biotype: protein_coding
description:
  Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; positive regulation by Lys14p suggests that lysine may be the primary substrate; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter; RTC2 has a paralog, YPQ1, that arose from the whole genome duplication; Belongs to the laat-1 family.


ensembl_gene_id: YBR148W
symbol: YSW1
gene_biotype: protein_coding
description:
  Spore-specific protein YSW1; Protein required for normal prospore membrane formation; interacts with Gip1p, which is the meiosis-specific regulatory subunit of the Glc7p protein phosphatase; expressed specifically in spores and localizes to the prospore membrane; YSW1 has a paralog, SPO21, that arose from the whole genome duplication.


ensembl_gene_id: YBR149W
symbol: ARA1
gene_biotype: protein_coding
description:
  D-arabinose dehydrogenase [NAD(P)+] heavy chain; NADP+ dependent arabinose dehydrogenase; involved in carbohydrate metabolism; purified as homodimer; naturally occurs with a N-terminus degradation product.


ensembl_gene_id: YBR150C
symbol: TBS1
gene_biotype: protein_coding
description:
  Uncharacterized transcriptional regulatory protein TBS1; Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; TBS1 has a paralog, HAL9, that arose from the whole genome duplication.


ensembl_gene_id: YBR151W
symbol: APD1
gene_biotype: protein_coding
description:
  Actin patches distal protein 1; Protein of unknown function; required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide; localizes to both cytoplasm and nucleus; Belongs to the APD1 family.


ensembl_gene_id: YBR152W
symbol: SPP381
gene_biotype: protein_coding
description:
  Pre-mRNA-splicing factor SPP381; mRNA splicing factor, component of U4/U6.U5 tri-snRNP; interacts genetically and physically with Prp38p; relocalizes to the cytosol in response to hypoxia; Belongs to the SPP381 family.


ensembl_gene_id: YBR153W
symbol: RIB7
gene_biotype: protein_coding
description:
  2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase; Diaminohydroxyphoshoribosylaminopyrimidine deaminase; catalyzes the second step of the riboflavin biosynthesis pathway; Belongs to the HTP reductase family.


ensembl_gene_id: YBR154C
symbol: RPB5
gene_biotype: protein_coding
description:
  RNA polymerase subunit ABC27; common to RNA polymerases I, II, and III; contacts DNA and affects transactivation; Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family.


ensembl_gene_id: YBR155W
symbol: CNS1
gene_biotype: protein_coding
description:
  Hsp70/Hsp90 co-chaperone CNS1; TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70); stimulates ATPase activity of Ssa1p; ts mutants reduce Hsp82p function, overexpression suppresses phenotypes of HSP82 ts allele and cpr7 deletion; human homolog TTC4 complements yeast cns1 mutant; Belongs to the TTC4 family.


ensembl_gene_id: YBR156C
symbol: SLI15
gene_biotype: protein_coding
description:
  Inner centromere protein-related protein SLI15; Subunit of the conserved chromosomal passenger complex (CPC); complex regulates kinetochore-microtubule attachments, activation of the spindle tension checkpoint, and mitotic spindle disassembly; other complex members are Ipl1p, Bir1p, and Nbl1p.


ensembl_gene_id: YBR157C
symbol: ICS2
gene_biotype: protein_coding
description:
  Increased copper sensitivity protein 2; Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization.


ensembl_gene_id: YBR158W
symbol: AMN1
gene_biotype: protein_coding
description:
  Antagonist of mitotic exit network protein 1; Protein required for daughter cell separation; multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN); Belongs to the AMN1 family.


ensembl_gene_id: YBR159W
symbol: IFA38
gene_biotype: protein_coding
description:
  Very-long-chain 3-oxoacyl-CoA reductase; Microsomal beta-keto-reductase; contains oleate response element (ORE) sequence in the promoter region; mutants exhibit reduced VLCFA synthesis, accumulate high levels of dihydrosphingosine, phytosphingosine and medium-chain ceramides; Belongs to the short-chain dehydrogenases/reductases (SDR) family.


ensembl_gene_id: YBR160W
symbol: CDC28
gene_biotype: protein_coding
description:
  Cyclin-dependent kinase (CDK) catalytic subunit; master regulator of mitotic and meiotic cell cycles; alternately associates with G1, S, G2/M phase cyclins, which provide substrate specificity; regulates metabolism, basal transcription, chromosome dynamics, growth and morphogenesis; transcript induction in osmostress involves antisense RNA; human homologs CDK1, CDK2, CDK3 can complement yeast conditional cdc28 mutants; human CDK1, CDK2 can complement yeast cdc28 null mutant.


ensembl_gene_id: YBR161W
symbol: CSH1
gene_biotype: protein_coding
description:
  Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Sur1p; CSH1 has a paralog, SUR1, that arose from the whole genome duplication.


ensembl_gene_id: YBR162C
symbol: TOS1
gene_biotype: protein_coding
description:
  Protein TOS1; Covalently-bound cell wall protein of unknown function; identified as a cell cycle regulated SBF target gene; deletion mutants are highly resistant to treatment with beta-1,3-glucanase; has sequence similarity to YJL171C; Belongs to the PGA52 family.


ensembl_gene_id: YBR162W-A
symbol: YSY6
gene_biotype: protein_coding
description:
  Protein of unknown function; expression suppresses a secretory pathway mutation in E. coli; has similarity to the mammalian RAMP4 protein involved in secretion.


ensembl_gene_id: YBR163W
symbol: EXO5
gene_biotype: protein_coding
description:
  Mitochondrial 5'-3' exonuclease and sliding exonuclease; required for mitochondrial genome maintenance; distantly related to the RecB nuclease domain of bacterial RecBCD recombinases; may be regulated by the transcription factor Ace2.


ensembl_gene_id: YBR164C
symbol: ARL1
gene_biotype: protein_coding
description:
  ADP-ribosylation factor-like protein 1; Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; role in membrane organization at trans-Golgi network; required for delivery of Atg9p to the phagophore assembly site during autophagy under high temperature stress; required with Ypt6p for starvation-induced autophagy; required for the CVT pathway under non-starvation conditions; G protein of the Ras superfamily, similar to ADP-ribosylation factor.


ensembl_gene_id: YBR165W
symbol: UBS1
gene_biotype: protein_coding
description:
  Ubiquitin-conjugating enzyme suppressor that regulates Cdc34p; functions as a general positive regulator of Cdc34p activity; nuclear protein that may represent a link between nucleocytoplasmic transport and ubiquitin ligase activity.


ensembl_gene_id: YBR166C
symbol: TYR1
gene_biotype: protein_coding
description:
  Prephenate dehydrogenase involved in tyrosine biosynthesis; expression is dependent on phenylalanine levels; Belongs to the prephenate/arogenate dehydrogenase family.


ensembl_gene_id: YBR167C
symbol: POP7
gene_biotype: protein_coding
description:
  Ribonucleases P/MRP protein subunit POP7; Subunit of RNase MRP, nuclear RNase P and telomerase; forms a soluble heterodimer with Pop6p that binds P3 domain of RNase MRP and RNase P RNAs; RNase MRP cleaves pre-rRNA, nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs, while telomerase replenishes telomeric DNA.


ensembl_gene_id: YBR168W
symbol: PEX32
gene_biotype: protein_coding
description:
  Peroxisomal integral membrane protein; involved in negative regulation of peroxisome size; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p.


ensembl_gene_id: YBR169C
symbol: SSE2
gene_biotype: protein_coding
description:
  Member of Hsp110 subclass of the heat shock protein 70 (HSP70) family; serves as nucleotide exchange factor to load ATP onto the SSA class of cytosolic Hsp70s; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication.


ensembl_gene_id: YBR170C
symbol: NPL4
gene_biotype: protein_coding
description:
  Nuclear protein localization protein 4; Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; assists Cdc48p in the dislocation of misfolded, polyubiquitinated ERAD substrates that are subsequently delivered to the proteasome for degradation; also involved in the regulated destruction of resident ER membrane proteins, such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing (RUP).


ensembl_gene_id: YBR171W
symbol: SEC66
gene_biotype: protein_coding
description:
  Translocation protein SEC66; Non-essential subunit of Sec63 complex; with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER; other members are Sec63p, Sec62p, and Sec72p.


ensembl_gene_id: YBR172C
symbol: SMY2
gene_biotype: protein_coding
description:
  GYF domain protein; involved in COPII vesicle formation; interacts with the Sec23p/Sec24p subcomplex; overexpression suppresses the temperature sensitivity of a myo2 mutant; similar to S. pombe Mpd2; SMY2 has a paralog, SYH1, that arose from the whole genome duplication; Belongs to the SMY2/mpd2 family.


ensembl_gene_id: YBR173C
symbol: UMP1
gene_biotype: protein_coding
description:
  Chaperone required for correct maturation of the 20S proteasome; short-lived chaperone; may inhibit premature dimerization of proteasome half-mers; degraded by proteasome upon completion of its assembly.


ensembl_gene_id: YBR174C
symbol: YBR174C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YBR174C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YBR175W; null mutant is viable and sporulation defective.


ensembl_gene_id: YBR175W
symbol: SWD3
gene_biotype: protein_coding
description:
  COMPASS component SWD3; Essential subunit of the COMPASS (Set1C) complex; COMPASS methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5.


ensembl_gene_id: YBR176W
symbol: ECM31
gene_biotype: protein_coding
description:
  Ketopantoate hydroxymethyltransferase; required for pantothenic acid biosynthesis, converts 2-oxoisovalerate into 2-dehydropantoate.


ensembl_gene_id: YBR177C
symbol: EHT1
gene_biotype: protein_coding
description:
  Acyl-coenzymeA:ethanol O-acyltransferase; plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; possesses short-chain esterase activity; localizes to lipid particles and the mitochondrial outer membrane; EHT1 has a paralog, EEB1, that arose from the whole genome duplication.


ensembl_gene_id: YBR178W
symbol: YBR178W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YBR178W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR177C.


ensembl_gene_id: YBR179C
symbol: FZO1
gene_biotype: protein_coding
description:
  Mitofusin; integral membrane protein involved in mitochondrial outer membrane tethering and fusion; role in mitochondrial genome maintenance; efficient tethering and degradation of Fzo1p requires an intact N-terminal GTPase domain; targeted for destruction by the ubiquitin ligase SCF-Mdm30p and the cytosolic ubiquitin-proteasome system; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. Mitofusin subfamily.


ensembl_gene_id: YBR180W
symbol: DTR1
gene_biotype: protein_coding
description:
  Putative dityrosine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; required for spore wall synthesis; sequence similarity to QDR1 and QDR3, and the triple mutant dtr1 qdr1 qdr3 exhibits reduced dityrosine fluorescence relative to the single mutants; expressed during sporulation.


ensembl_gene_id: YBR181C
symbol: RPS6B
gene_biotype: protein_coding
description:
  Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; phosphorylated on S233 by Ypk3p in a TORC1-dependent manner, and on S232 in a TORC1/2-dependent manner by Ypk1/2/3p; RPS6B has a paralog, RPS6A, that arose from the whole genome duplication.


ensembl_gene_id: YBR182C
symbol: SMP1
gene_biotype: protein_coding
description:
  MADS-box transcription factor involved in osmotic stress response; SMP1 has a paralog, RLM1, that arose from the whole genome duplication; Belongs to the MEF2 family.


ensembl_gene_id: YBR182C-A
symbol: YBR182C-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YBR182C-A; Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching.


ensembl_gene_id: YBR183W
symbol: YPC1
gene_biotype: protein_coding
description:
  Alkaline ceramidase; also has reverse (CoA-independent) ceramide synthase activity; catalyzes both breakdown and synthesis of phytoceramide; overexpression confers fumonisin B1 resistance; YPC1 has a paralog, YDC1, that arose from the whole genome duplication.


ensembl_gene_id: YBR185C
symbol: MBA1
gene_biotype: protein_coding
description:
  Membrane-associated mitochondrial ribosome receptor; forms a complex with Mdm38p that may facilitate recruitment of mRNA-specific translational activators to ribosomes; possible role in protein export from the matrix to inner membrane.


ensembl_gene_id: YBR186W
symbol: PCH2
gene_biotype: protein_coding
description:
  Pachytene checkpoint protein 2; Hexameric ring ATPase that remodels chromosome axis protein Hop1p; nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in rDNA; required for meiotic double-stranded break formation.


ensembl_gene_id: YBR187W
symbol: GDT1
gene_biotype: protein_coding
description:
  GCR1-dependent translation factor 1; Calcium transporter localized to the cis- and medial-Golgi apparatus; required for protein glycosylation; GFP-fusion protein localizes to the vacuole; TMEM165, a human gene which causes Congenital Disorders of Glycosylation is orthologous and functionally complements the null allele; expression pattern and physical interactions suggest a possible role in ribosome biogenesis; expression reduced in a gcr1 null mutant; Belongs to the GDT1 family.


ensembl_gene_id: YBR188C
symbol: NTC20
gene_biotype: protein_coding
description:
  Pre-mRNA-splicing factor NTC20; Member of the NineTeen Complex (NTC); this complex contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs.


ensembl_gene_id: YBR189W
symbol: RPS9B
gene_biotype: protein_coding
description:
  Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9B has a paralog, RPS9A, that arose from the whole genome duplication.


ensembl_gene_id: YBR190W
symbol: YBR190W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YBR190W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ribosomal protein gene RPL21A/YBR191W.


ensembl_gene_id: YBR191W
symbol: RPL21A
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L21A; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21A has a paralog, RPL21B, that arose from the whole genome duplication.


ensembl_gene_id: YBR191W-A
symbol: YBR191W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YBR191W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YBR192W
symbol: RIM2
gene_biotype: protein_coding
description:
  Mitochondrial carrier protein RIM2; Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family.


ensembl_gene_id: YBR193C
symbol: MED8
gene_biotype: protein_coding
description:
  Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation.


ensembl_gene_id: YBR194W
symbol: AIM4
gene_biotype: protein_coding
description:
  Altered inheritance of mitochondria protein 4; Protein proposed to be associated with the nuclear pore complex; null mutant is viable, displays elevated frequency of mitochondrial genome loss and is sensitive to freeze-thaw stress; Belongs to the AIM4 family.


ensembl_gene_id: YBR195C
symbol: MSI1
gene_biotype: protein_coding
description:
  Subunit of chromatin assembly factor I (CAF-1); chromatin assembly by CAF-1 affects multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of DNA damage checkpoint after DNA repair; chromatin dynamics during transcription; and repression of divergent noncoding transcription; Msi1p localizes to nucleus and cytoplasm and independently regulates the RAS/cAMP pathway via sequestration of Npr1p kinase.


ensembl_gene_id: YBR196C
symbol: PGI1
gene_biotype: protein_coding
description:
  Glycolytic enzyme phosphoglucose isomerase; catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate; required for cell cycle progression and completion of the gluconeogenic events of sporulation.


ensembl_gene_id: YBR196C-A
symbol: YBR196C-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YBR196C-A; Putative protein of unknown function; identified by fungal homology and RT-PCR.


ensembl_gene_id: YBR196C-B
symbol: YBR196C-B
gene_biotype: protein_coding
description:
  Uncharacterized protein YBR196C-B; Putative protein of unknown function; identified by expression profiling and mass spectrometry.


ensembl_gene_id: YBR197C
symbol: YBR197C
gene_biotype: protein_coding
description:
  Uncharacterized protein YBR197C; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR197C is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress; YBR197C has a paralog, YPL077C, that arose from the whole genome duplication.


ensembl_gene_id: YBR198C
symbol: TAF5
gene_biotype: protein_coding
description:
  Subunit (90 kDa) of TFIID and SAGA complexes; involved in RNA polymerase II transcription initiation and in chromatin modification.


ensembl_gene_id: YBR199W
symbol: KTR4
gene_biotype: protein_coding
description:
  Probable mannosyltransferase KTR4; Glycosyltransferase involved in protein glycosylation; transfers GDP-mannose to methyl-alpha-mannoside in vitro; member of the KRE2/MNT1 mannosyltransferase family of type II membrane proteins with a short cytoplasmic N-terminus, a membrane-spanning region and a highly conserved catalytic lumenal domain.


ensembl_gene_id: YBR200W
symbol: BEM1
gene_biotype: protein_coding
description:
  Bud emergence protein 1; Protein containing SH3-domains; involved in establishing cell polarity and morphogenesis; functions as a scaffold protein for complexes that include Cdc24p, Ste5p, Ste20p, and Rsr1p.


ensembl_gene_id: YBR200W-A
symbol: YBR200W-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YBR200W-A; Putative protein of unknown function; identified by fungal homology and RT-PCR.


ensembl_gene_id: YBR201W
symbol: DER1
gene_biotype: protein_coding
description:
  Degradation in the endoplasmic reticulum protein 1; ER membrane protein that promotes export of misfolded polypeptides; required for ER-associated protein degradation of misfolded or unassembled proteins; initiates export of aberrant polypeptides from ER lumen by threading them into ER membrane and routing them to Hrd1p for ubiquitination; function normally requires N-terminal acetylation by NatB; N- and C- termini protrude into cytoplasm; similar to Dfm1p; homolog of mammalian derlin-1.


ensembl_gene_id: YBR202W
symbol: MCM7
gene_biotype: protein_coding
description:
  DNA replication licensing factor MCM7; Component of the Mcm2-7 hexameric helicase complex; MCM2-7 primes origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation in S-phase; forms an Mcm4p-6p-7p subcomplex.


ensembl_gene_id: YBR203W
symbol: COS111
gene_biotype: protein_coding
description:
  F-box protein COS111; Protein required for antifungal drug ciclopirox olamine resistance; not related to the subtelomerically-encoded COS family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies.


ensembl_gene_id: YBR204C
symbol: LDH1
gene_biotype: protein_coding
description:
  Lipid droplet hydrolase 1; Serine hydrolase; exhibits active esterase plus weak triacylglycerol lipase activities; proposed role in lipid homeostasis, regulating phospholipid and non-polar lipid levels and required for mobilization of LD-stored lipids; localizes to the lipid droplet (LD) surface; contains a classical serine containing catalytic triad (GxSxG motif).


ensembl_gene_id: YBR205W
symbol: KTR3
gene_biotype: protein_coding
description:
  Probable mannosyltransferase KTR3; Putative alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; Svp26p mediates uptake of Ktr3p into COPII vesicles; relocalizes from nucleus to vacuole upon DNA replication stress; Belongs to the glycosyltransferase 15 family.


ensembl_gene_id: YBR206W
symbol: YBR206W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YBR206W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene KTR3.


ensembl_gene_id: YBR207W
symbol: FTH1
gene_biotype: protein_coding
description:
  Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YBR208C
symbol: DUR1,2
gene_biotype: protein_coding
description:
  Allophanate hydrolase; Urea amidolyase; contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YBR209W
symbol: YBR209W
gene_biotype: protein_coding
description:
  Uncharacterized protein YBR209W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; YBR209W is not an essential gene.


ensembl_gene_id: YBR210W
symbol: ERV15
gene_biotype: protein_coding
description:
  ER-derived vesicles protein ERV15; Protein involved in export of proteins from the endoplasmic reticulum; ERV15 has a paralog, ERV14, that arose from the whole genome duplication.


ensembl_gene_id: YBR211C
symbol: AME1
gene_biotype: protein_coding
description:
  Inner kinetochore subunit AME1; Essential kinetochore protein associated with microtubules and SPBs; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p); involved in spindle checkpoint maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-U and fission yeast Mis17; relative distribution to the nucleus increases upon DNA replication stress; Belongs to the CENP-U/AME1 family.


ensembl_gene_id: YBR212W
symbol: NGR1
gene_biotype: protein_coding
description:
  RNA binding protein that negatively regulates growth rate; interacts with the 3' UTR of the mitochondrial porin (POR1) mRNA and enhances its degradation; overexpression impairs mitochondrial function; interacts with Dhh1p to mediate POR1 mRNA decay; expressed in stationary phase.


ensembl_gene_id: YBR213W
symbol: MET8
gene_biotype: protein_coding
description:
  Siroheme biosynthesis protein MET8; Bifunctional dehydrogenase and ferrochelatase; involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis; Belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. MET8 subfamily.


ensembl_gene_id: YBR214W
symbol: SDS24
gene_biotype: protein_coding
description:
  Protein involved in cell separation during budding; one of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; may play an indirect role in fluid-phase endocytosis; protein abundance increases in response to DNA replication stress; SDS24 has a paralog, SDS23, that arose from the whole genome duplication.


ensembl_gene_id: YBR215W
symbol: HPC2
gene_biotype: protein_coding
description:
  Histone promoter control protein 2; Subunit of the HIR complex; HIR is a nucleosome assembly complex involved in regulation of histone gene transcription; mutants display synthetic defects with subunits of FACT, a complex that allows passage of RNA Pol II through nucleosomes.


ensembl_gene_id: YBR216C
symbol: YBP1
gene_biotype: protein_coding
description:
  YAP1-binding protein 1; Protein involved in cellular response to oxidative stress; required for oxidation of specific cysteine residues of transcription factor Yap1p, resulting in nuclear localization of Yap1p in response to stress; YBP1 has a paralog, YBP2, that arose from the whole genome duplication.


ensembl_gene_id: YBR217W
symbol: ATG12
gene_biotype: protein_coding
description:
  Ubiquitin-like protein ATG12; Ubiquitin-like modifier involved in autophagy and the Cvt pathway; conserved; conjugated to Atg5p to form a complex involved in Atg8p lipidation; Atg5p-Atg12p conjugate enhances E2 activity of Atg3p by rearranging its catalytic site, also forms a complex with Atg16p; the Atg5-Atg12/Atg16 complex binds to membranes and is essential for autophagosome formation.


ensembl_gene_id: YBR218C
symbol: PYC2
gene_biotype: protein_coding
description:
  Pyruvate carboxylase isoform; cytoplasmic enzyme that converts pyruvate to oxaloacetate; differentially regulated than isoform Pyc1p; mutations in the human homolog are associated with lactic acidosis; PYC2 has a paralog, PYC1, that arose from the whole genome duplication.


ensembl_gene_id: YBR221C
symbol: PDB1
gene_biotype: protein_coding
description:
  E1 beta subunit of the pyruvate dehydrogenase (PDH) complex; PDH is an evolutionarily conserved multi-protein complex found in mitochondria.


ensembl_gene_id: YBR221W-A
symbol: YBR221W-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YBR221W-A; Putative protein of unknown function; identified by expression profiling and mass spectrometry.


ensembl_gene_id: YBR222C
symbol: PCS60
gene_biotype: protein_coding
description:
  Oxalyl-CoA synthetase; capable of catalyzing conversion of oxalate to oxalyl-CoA; catalyzes first step in pathway of oxalate degradation that functions to protect yeast from inhibitory effects of oxalate; peroxisomal protein that binds mRNA; localizes to both peroxisomal peripheral membrane and matrix, expression is highly inducible by oleic acid; similar to E. coli long chain acyl-CoA synthetase; Belongs to the ATP-dependent AMP-binding enzyme family.


ensembl_gene_id: YBR223C
symbol: TDP1
gene_biotype: protein_coding
description:
  Tyrosyl-DNA phosphodiesterase I; hydrolyzes 3' and 5'-phosphotyrosyl bonds; involved in the repair of DNA lesions created by topo I and topo II; mutations in the human homolog, TDP1, result in the a neurodegenerative disease, spinocerebellar ataxia with axonal neuropathy (SCAN1); yeast cells and human rhabdomyosarcoma lines that overexpress TDP1 both exhibit elevated dosage chromosomal instability (dCIN).


ensembl_gene_id: YBR223W-A
symbol: YBR223W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YBR223W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps YBR223C; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching.


ensembl_gene_id: YBR224W
symbol: YBR224W
gene_biotype: protein_coding
description:
  Putative uncharacterized membrane protein YBR224W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TDP1.


ensembl_gene_id: YBR225W
symbol: YBR225W
gene_biotype: protein_coding
description:
  Uncharacterized protein YBR225W; Putative protein of unknown function; non-essential gene identified in a screen for mutants affected in mannosylphophorylation of cell wall components.


ensembl_gene_id: YBR226C
symbol: YBR226C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YBR226C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YBR225W.


ensembl_gene_id: YBR227C
symbol: MCX1
gene_biotype: protein_coding
description:
  ATP-dependent clpX-like chaperone, mitochondrial; Non-proteolytic ATPase of the AAA family; stimulates incorporation of the pyridoxal phosphate cofactor into Hem1p (5-aminolevulinic acid synthase); localized to the mitochondrial matrix; ortholog of vertebrate CLPX, which promotes erythropoiesis.


ensembl_gene_id: YBR228W
symbol: SLX1
gene_biotype: protein_coding
description:
  Endonuclease involved in DNA recombination and repair; subunit of a complex, with Slx4p, that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks; function overlaps with that of Sgs1p-Top3p.


ensembl_gene_id: YBR229C
symbol: ROT2
gene_biotype: protein_coding
description:
  Glucosidase II catalytic subunit; required to trim the final glucose in N-linked glycans; required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations; Belongs to the glycosyl hydrolase 31 family.


ensembl_gene_id: YBR230C
symbol: OM14
gene_biotype: protein_coding
description:
  Mitochondrial outer membrane receptor for cytosolic ribosomes; integral protein of the outer membrane that interacts with the nascent chain-associated complex (NAC) bound to ribosomes, contributing to co-translational mitochondrial import; interacts with porin (Por1p) and Om45p; abundance is decreased in cells grown in glucose relative to other carbon sources.


ensembl_gene_id: YBR230W-A
symbol: YBR230W-A
gene_biotype: protein_coding
description:
  Putative protein of unknown function; YBR230W-A has a paralog, COQ8, that arose from the whole genome duplication.


ensembl_gene_id: YBR231C
symbol: SWC5
gene_biotype: protein_coding
description:
  SWR1-complex protein 5; Component of the SWR1 complex; complex exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; protein abundance increases in response to DNA replication stress; relocalizes to the cytosol in response to hypoxia; Belongs to the SWC5 family.


ensembl_gene_id: YBR232C
symbol: YBR232C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YBR232C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YBR233W
symbol: PBP2
gene_biotype: protein_coding
description:
  PAB1-binding protein 2; RNA binding protein; has similarity to mammalian heterogeneous nuclear RNP K protein, involved in the regulation of telomere position effect and telomere length; relative distribution to the nucleus increases upon DNA replication stress.


ensembl_gene_id: YBR233W-A
symbol: DAD3
gene_biotype: protein_coding
description:
  Essential subunit of the Dam1 complex (aka DASH complex); complex couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis.


ensembl_gene_id: YBR234C
symbol: ARC40
gene_biotype: protein_coding
description:
  Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches; Belongs to the WD repeat ARPC1 family.


ensembl_gene_id: YBR235W
symbol: VHC1
gene_biotype: protein_coding
description:
  Vacuolar membrane cation-chloride cotransporter (CCC); likely mediates K+ and Cl- cotransport into the vacuole; has a role in potassium homeostasis and salt tolerance; localizes to sites of contact between the vacuole and mitochondria (vCLAMPs); similar to mammalian electroneutral Na(+)-(K+)-C1- cotransporter family.


ensembl_gene_id: YBR236C
symbol: ABD1
gene_biotype: protein_coding
description:
  mRNA cap guanine-N7 methyltransferase; Methyltransferase; catalyzes the transfer of a methyl group from S-adenosylmethionine to the GpppN terminus of capped mRNA; nuclear protein that relocalizes to the cytosol in response to hypoxia; Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.


ensembl_gene_id: YBR237W
symbol: PRP5
gene_biotype: protein_coding
description:
  Pre-mRNA-processing ATP-dependent RNA helicase PRP5; RNA helicase in the DEAD-box family; necessary for prespliceosome formation, bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA; Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily.


ensembl_gene_id: YBR238C
symbol: YBR238C
gene_biotype: protein_coding
description:
  Mitochondrial membrane protein; not required for respiratory growth but causes a synthetic respiratory defect in combination with rmd9 mutations; transcriptionally up-regulated by TOR; deletion increases life span; YBR238C has a paralog, RMD9, that arose from the whole genome duplication.


ensembl_gene_id: YBR239C
symbol: ERT1
gene_biotype: protein_coding
description:
  Transcriptional regulator; involved in regulation of gluconeogenesis and fermentable carbon utilization; GFP-fusion protein localizes to cytoplasm, nucleus; null mutation affects periodicity of transcriptional and metabolic oscillation; plays role in restricting Ty1 transposition; member of the zinc cluster family of proteins, similar to Rds2p.


ensembl_gene_id: YBR240C
symbol: THI2
gene_biotype: protein_coding
description:
  Thiamine biosynthesis regulatory protein; Transcriptional activator of thiamine biosynthetic genes; interacts with regulatory factor Thi3p to control expression of thiamine biosynthetic genes with respect to thiamine availability; acts together with Pdc2p to respond to thiaminediphosphate demand, possibly as related to carbon source availability; zinc finger protein of the Zn(II)2Cys6 type.


ensembl_gene_id: YBR241C
symbol: YBR241C
gene_biotype: protein_coding
description:
  Probable metabolite transport protein YBR241C; Putative transporter, member of the sugar porter family; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane; YBR241C is not an essential gene; YBR241C has a paralog, VPS73, that arose from the whole genome duplication.


ensembl_gene_id: YBR242W
symbol: YBR242W
gene_biotype: protein_coding
description:
  HD domain-containing protein YBR242W; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR242W is not an essential gene; YBR242W has a paralog, YGL101W, that arose from the whole genome duplication.


ensembl_gene_id: YBR243C
symbol: ALG7
gene_biotype: protein_coding
description:
  UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase; UDP-N-acetyl-glucosamine-1-P transferase; transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin; human homolog DPAGT1 can complement yeast ALG7 mutant; Belongs to the glycosyltransferase 4 family.


ensembl_gene_id: YBR244W
symbol: GPX2
gene_biotype: protein_coding
description:
  Glutathione peroxidase-like peroxiredoxin 2; Phospholipid hydroperoxide glutathione peroxidase; protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress; induced by glucose starvation; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YBR245C
symbol: ISW1
gene_biotype: protein_coding
description:
  ISWI chromatin-remodeling complex ATPase ISW1; ATPase subunit of imitation-switch (ISWI) class chromatin remodelers; with Ioc3p forms Isw1a complex involved in repression of transcription initiation; with Ioc2p and Ioc4p forms Isw1b complex involved in regulation of transcription elongation; Isw1b recruited to ORFs by H3K36 methylation and acts with Chd1p to prevent trans-histone exchange over coding regions; Isw1p import into nucleus depends on C-terminal bipartite nuclear targeting signal KRIR X19 KKAK.


ensembl_gene_id: YBR246W
symbol: RRT2
gene_biotype: protein_coding
description:
  Diphthine methyltransferase; Methylesterase performing penultimate step of diphthamide biosynthesis; hydrolyzes methylated diphthine to produce diphthine and allows Dph6-catalyzed amidation reaction to occur; deletion leads to resistance to sordarin and accumulation of methylatediphthine; WD40 domain-containing protein; involved in endosomal recycling; forms complex with Rtt10p that functions in retromer-mediated pathway for recycling internalized cell-surface proteins.


ensembl_gene_id: YBR247C
symbol: ENP1
gene_biotype: protein_coding
description:
  Protein associated with U3 and U14 snoRNAs; required for pre-rRNA processing and 40S ribosomal subunit synthesis; localized in the nucleus and concentrated in the nucleolus; human BYSL functionally complements the heat sensitivity of an enp1 ts mutant; Belongs to the bystin family.


ensembl_gene_id: YBR248C
symbol: HIS7
gene_biotype: protein_coding
description:
  Imidazole glycerol phosphate synthase; glutamine amidotransferase:cyclase that catalyzes the fifth step of histidine biosynthesis and also produces 5-aminoimidazole-4-carboxamide ribotide (AICAR), a purine precursor.


ensembl_gene_id: YBR249C
symbol: ARO4
gene_biotype: protein_coding
description:
  Phospho-2-dehydro-3-deoxyheptonate aldolase, tyrosine-inhibited; 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase; catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan; relative distribution to the nucleus increases upon DNA replication stress.


ensembl_gene_id: YBR250W
symbol: SPO23
gene_biotype: protein_coding
description:
  Sporulation protein 23; Protein of unknown function; associates with meiosis-specific protein Spo1p.


ensembl_gene_id: YBR252W
symbol: DUT1
gene_biotype: protein_coding
description:
  Deoxyuridine 5'-triphosphate nucleotidohydrolase; Deoxyuridine triphosphate diphosphatase (dUTPase); catalyzes hydrolysis of dUTP to dUMP and PPi, thereby preventing incorporation of uracil into DNA during replication; critical for the maintenance of genetic stability; also has diphosphatase activity on deoxyinosine triphosphate; human homolog DUT allows growth of yeast haploid dut1 null mutant after sporulation of heterozygous diploid.


ensembl_gene_id: YBR254C
symbol: TRS20
gene_biotype: protein_coding
description:
  Core component of transport protein particle (TRAPP) complexes I-III; TRAPPs are multimeric guanine nucleotide-exchange factors for GTPase Ypt1p, regulating ER-Golgi traffic (TRAPPI), intra-Golgi traffic (TRAPPII), endosome-Golgi traffic (TRAPPII and III) and autophagy (TRAPPIII); mutation leads to defects in endocytic recycling, block in sporulation/meiosis; mutations in human homolog TRAPPC2 cause spondyloepiphyseal dysplasia tarda, TRAPPC2 can complement yeast null mutant.


ensembl_gene_id: YBR255C-A
symbol: RCF3
gene_biotype: protein_coding
description:
  Uncharacterized protein YBR255C-A; Putative protein of unknown function; may interact with respiratory chain complexes III (ubiquinol-cytochrome c reductase) or IV (cytochrome c oxidase); identified by sequence comparison with hemiascomycetous yeast species.


ensembl_gene_id: YBR255W
symbol: MTC4
gene_biotype: protein_coding
description:
  Maintenance of telomere capping protein 4; Protein of unknown function; required for normal growth rate at 15 degrees C; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; mtc4 is synthetically sick with cdc13-1.


ensembl_gene_id: YBR257W
symbol: POP4
gene_biotype: protein_coding
description:
  RNases MRP/P 32.9 kDa subunit; Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P.


ensembl_gene_id: YBR258C
symbol: SHG1
gene_biotype: protein_coding
description:
  COMPASS component SHG1; Subunit of the COMPASS (Set1C) complex; COMPASS methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres.


ensembl_gene_id: YBR259W
symbol: YBR259W
gene_biotype: protein_coding
description:
  Protein of unknown function; YBR259W is not an essential gene; forms cytoplasmic foci upon DNA replication stress.


ensembl_gene_id: YBR260C
symbol: RGD1
gene_biotype: protein_coding
description:
  GTPase-activating protein (RhoGAP) for Rho3p and Rho4p; possibly involved in control of actin cytoskeleton organization.


ensembl_gene_id: YBR261C
symbol: TAE1
gene_biotype: protein_coding
description:
  Alpha N-terminal protein methyltransferase 1; AdoMet-dependent proline methyltransferase; catalyzes the dimethylation of ribosomal proteins Rpl12 and Rps25 at N-terminal proline residues; has a role in protein synthesis; fusion protein localizes to the cytoplasm.


ensembl_gene_id: YBR262C
symbol: MIC12
gene_biotype: protein_coding
description:
  Component of the MICOS complex; MICOS (formerly MINOS or MitOS) is a mitochondrial inner membrane complex that extends into the intermembrane space and has a role in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane; forms a subcomplex with Mic10p and Mic27p whose assembly and stability requires cardiolipin.


ensembl_gene_id: YBR263W
symbol: SHM1
gene_biotype: protein_coding
description:
  Mitochondrial serine hydroxymethyltransferase; converts serine to glycine plus 5,10 methylenetetrahydrofolate; involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis; reverse reaction generates serine; Belongs to the SHMT family.


ensembl_gene_id: YBR264C
symbol: YPT10
gene_biotype: protein_coding
description:
  Rab family GTP-binding protein; contains the PEST signal sequence specific for proteolytic enzymes; may be involved in vesicular transport; overexpression leads to accumulation of Golgi-like cisternae with budding vesicles.


ensembl_gene_id: YBR265W
symbol: TSC10
gene_biotype: protein_coding
description:
  3-ketodihydrosphingosine reductase TSC10; 3-ketosphinganine reductase; catalyzes the second step in phytosphingosine synthesis; essential for growth in the absence of exogenous dihydrosphingosine or phytosphingosine; localized to lipid droplets; member of short chain dehydrogenase/reductase protein family.


ensembl_gene_id: YBR266C
symbol: SLM6
gene_biotype: protein_coding
description:
  Protein with a potential role in actin cytoskeleton organization; gene exhibits synthetic genetic interaction with MSS4 encoding phosphatidylinositol 4-phosphate kinase.


ensembl_gene_id: YBR267W
symbol: REI1
gene_biotype: protein_coding
description:
  Cytoplasmic pre-60S factor; required for the correct recycling of shuttling factors Alb1, Arx1 and Tif6 at the end of the ribosomal large subunit biogenesis; involved in bud growth in the mitotic signaling network.


ensembl_gene_id: YBR269C
symbol: SDH8
gene_biotype: protein_coding
description:
  Protein required for assembly of succinate dehydrogenase; interacts with flavinylated Sdh1p and may function as a chaperone for free Sdh1p, protecting its FAD cofactor from redox reactions before assembly of the complex; soluble protein of the mitochondrial matrix; respiratory defect of null mutant is functionally complemented by Drosophila and human orthologs.


ensembl_gene_id: YBR270C
symbol: BIT2
gene_biotype: protein_coding
description:
  Subunit of TORC2 membrane-associated complex; involved in regulation of actin cytoskeletal dynamics during polarized growth and cell wall integrity; interacts with Slm1p and Slm2p, homologous PH domain-containing TORC2 substrates; BIT2 has a paralog, BIT61, that arose from the whole genome duplication.


ensembl_gene_id: YBR271W
symbol: EFM2
gene_biotype: protein_coding
description:
  Protein-lysine N-methyltransferase EFM2; S-adenosylmethionine-dependent methyltransferase; seven-beta-strand lysine methyltransferase which dimethylates translation elongation factor EF2 (Eft1p and Eft2p) at lysine 613 and methylates EF3 (Yef3p) at lysine 187; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; involved in regulation of translational termination; predicted involvement in ribosome biogenesis; Belongs to the class I-like SAM-binding methyltransferase superfamily. METTL21 family.


ensembl_gene_id: YBR272C
symbol: HSM3
gene_biotype: protein_coding
description:
  DNA mismatch repair protein HSM3; Evolutionarily conserved 19S regulatory particle assembly-chaperone; involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); involved in DNA mismatch repair during slow growth; weak similarity to Msh1p; structural study suggests Hsm3p is a scaffold protein for Rpt1p-Rpt2p complex formation; ortholog of human 19S subunit S5b.


ensembl_gene_id: YBR273C
symbol: UBX7
gene_biotype: protein_coding
description:
  UBX (ubiquitin regulatory X) domain-containing protein; interacts with Cdc48p; UBX7 has a paralog, UBX6, that arose from the whole genome duplication.


ensembl_gene_id: YBR274W
symbol: CHK1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase CHK1; Serine/threonine kinase and DNA damage checkpoint effector; mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.


ensembl_gene_id: YBR275C
symbol: RIF1
gene_biotype: protein_coding
description:
  Telomere length regulator protein RIF1; Protein that binds to the Rap1p C-terminus; acts synergistically with Rif2p to help control telomere length and establish telomeric silencing; involved in control of DNA replication; contributes to resection of DNA double strand breaks (DSBs); deletion results in telomere elongation; Belongs to the RIF1 family.


ensembl_gene_id: YBR276C
symbol: PPS1
gene_biotype: protein_coding
description:
  Protein phosphatase; has specificity for serine, threonine, and tyrosine residues; has a role in the DNA synthesis phase of the cell cycle; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.


ensembl_gene_id: YBR277C
symbol: YBR277C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YBR277C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR278W.


ensembl_gene_id: YBR278W
symbol: DPB3
gene_biotype: protein_coding
description:
  Third-largest subunit of DNA polymerase II (DNA polymerase epsilon); required to maintain fidelity of chromosomal replication and also for inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; mRNA abundance peaks at the G1/S boundary of the cell cycle; DPB3 has a paralog, DLS1, that arose from the whole genome duplication.


ensembl_gene_id: YBR279W
symbol: PAF1
gene_biotype: protein_coding
description:
  RNA polymerase II-associated protein 1; Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cell cycle-regulated genes; involved in SER3 repression by helping to maintain SRG1 transcription-dependent nucleosome occupancy; homolog of human PD2/hPAF1.


ensembl_gene_id: YBR280C
symbol: SAF1
gene_biotype: protein_coding
description:
  SCF-associated factor 1; F-Box protein involved in proteasome-dependent degradation of Aah1p; involved in proteasome-dependent degradation of Aah1p during entry of cells into quiescence; interacts with Skp1.


ensembl_gene_id: YBR281C
symbol: DUG2
gene_biotype: protein_coding
description:
  Probable di- and tripeptidase DUG2; Component of glutamine amidotransferase (GATase II); forms a complex with Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p).


ensembl_gene_id: YBR282W
symbol: MRPL27
gene_biotype: protein_coding
description:
  Mitochondrial ribosomal protein of the large subunit; homolog of human Bcl-2 interacting protein BMRP.


ensembl_gene_id: YBR283C
symbol: SSH1
gene_biotype: protein_coding
description:
  Subunit of the Ssh1 translocon complex; Sec61p homolog involved in co-translational pathway of protein translocation; not essential.


ensembl_gene_id: YBR284W
symbol: YBR284W
gene_biotype: protein_coding
description:
  Inactive deaminase YBR284W; Putative metallo-dependent hydrolase superfamily protein; similar to AMP deaminases but lacks key catalytic residues and does not rescue purine nucleotide metabolic defect of quadruple aah1 ade8 amd1 his1 mutant; null mutant exhibits longer telomeres, altered Ty mobility, decreased resistance to rapamycin and wortmannin; induced in response to hydrostatic pressure; not an essential gene; YBR284W has a paralog, YJL070C, that arose from the whole genome duplication.


ensembl_gene_id: YBR287W
symbol: YBR287W
gene_biotype: protein_coding
description:
  Uncharacterized transporter YBR287W; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER; YBR287W is not an essential gene; Belongs to the auxin efflux carrier (TC 2.A.69) family.


ensembl_gene_id: YBR288C
symbol: APM3
gene_biotype: protein_coding
description:
  Mu3-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway.


ensembl_gene_id: YBR289W
symbol: SNF5
gene_biotype: protein_coding
description:
  Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf6p; relocates to the cytosol under hypoxic conditions.


ensembl_gene_id: YBR290W
symbol: BSD2
gene_biotype: protein_coding
description:
  Heavy metal ion homeostasis protein; facilitates trafficking of Smf1p and Smf2p metal transporters to vacuole where they are degraded; acts as an adaptor protein with Rsp5p in the regulated endocytosis of Smf1p and is itself ubiquitylated by Rsp5p; controls metal ion transport, prevents metal hyperaccumulation, functions in copper detoxification; Belongs to the BSD2 family.


ensembl_gene_id: YBR291C
symbol: CTP1
gene_biotype: protein_coding
description:
  Tricarboxylate transport protein; Mitochondrial inner membrane citrate transporter; member of the mitochondrial carrier family.


ensembl_gene_id: YBR292C
symbol: YBR292C
gene_biotype: protein_coding
description:
  Uncharacterized protein YBR292C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene.


ensembl_gene_id: YBR293W
symbol: VBA2
gene_biotype: protein_coding
description:
  Permease of basic amino acids in the vacuolar membrane; Belongs to the major facilitator superfamily.


ensembl_gene_id: YBR294W
symbol: SUL1
gene_biotype: protein_coding
description:
  High affinity sulfate permease of the SulP anion transporter family; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates; Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.


ensembl_gene_id: YBR295W
symbol: PCA1
gene_biotype: protein_coding
description:
  Cadmium transporting P-type ATPase; may also have a role in copper and iron homeostasis; stabilized by Cd binding, which prevents ubiquitination; S288C and other lab strains contain a G970R mutation which eliminates Cd transport function; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.


ensembl_gene_id: YBR296C
symbol: PHO89
gene_biotype: protein_coding
description:
  Phosphate permease PHO89; Plasma membrane Na+/Pi cotransporter; active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p; mutations in related human transporter genes hPit1 and hPit2 are associated with hyperphosphatemia-induced calcification of vascular tissue and familial idiopathic basal ganglia calcification.


ensembl_gene_id: YBR296C-A
symbol: YBR296C-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YBR296C-A; Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching.


ensembl_gene_id: YBR297W
symbol: MAL33
gene_biotype: protein_coding
description:
  Maltose fermentation regulatory protein MAL33; MAL-activator protein; part of complex locus MAL3; nonfunctional in genomic reference strain S288C; Belongs to the MAL13 family.


ensembl_gene_id: YBR298C
symbol: MAL31
gene_biotype: protein_coding
description:
  Maltose permease; high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL3 complex locus; member of the 12 transmembrane domain superfamily of sugar transporters; functional in genomic reference strain S288C.


ensembl_gene_id: YBR298C-A
symbol: YBR298C-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YBR298C-A; Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching.


ensembl_gene_id: YBR299W
symbol: MAL32
gene_biotype: protein_coding
description:
  Alpha-glucosidase MAL32; Maltase (alpha-D-glucosidase); inducible protein involved in maltose catabolism; encoded in the MAL3 complex locus; functional in genomic reference strain S288C; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose; Belongs to the glycosyl hydrolase 13 family.


ensembl_gene_id: YBR300C
symbol: YBR300C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YBR300C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR301W; YBR300C is not an essential gene.


ensembl_gene_id: YBR301W
symbol: PAU24
gene_biotype: protein_coding
description:
  Seripauperin-24; Cell wall mannoprotein; has similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth; Belongs to the SRP1/TIP1 family. Seripauperin subfamily.


ensembl_gene_id: YBR302C
symbol: COS2
gene_biotype: protein_coding
description:
  Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins.


ensembl_gene_id: YCL001W
symbol: RER1
gene_biotype: protein_coding
description:
  Protein involved in retention of membrane proteins; including Sec12p, in the ER; localized to Golgi; functions as a retrieval receptor in returning membrane proteins to the ER.


ensembl_gene_id: YCL001W-A
symbol: YCL001W-A
gene_biotype: protein_coding
description:
  Putative protein of unknown function; YCL001W-A gene has similarity to DOM34 and is present in a region duplicated between chromosomes XIV and III; Belongs to the eukaryotic release factor 1 family. Pelota subfamily. Highly divergent.


ensembl_gene_id: YCL001W-B
symbol: YCL001W-B
gene_biotype: protein_coding
description:
  Putative protein of unknown function; present in a region duplicated between chromosomes XIV and III; YCL001W-B has a paralog, DOM34, that arose from the whole genome duplication; Belongs to the eukaryotic release factor 1 family. Pelota subfamily. Highly divergent.


ensembl_gene_id: YCL004W
symbol: PGS1
gene_biotype: protein_coding
description:
  CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Phosphatidylglycerolphosphate synthase; catalyzes the synthesis of phosphatidylglycerolphosphate from CDP-diacylglycerol and sn-glycerol 3-phosphate in the first committed and rate-limiting step of cardiolipin biosynthesis.


ensembl_gene_id: YCL005W
symbol: LDB16
gene_biotype: protein_coding
description:
  Protein involved in lipid droplet (LD) assembly; forms a complex with Sei1p at ER-LD contact sites, stabilizing contact sites; ensures that LDs bud from the ER towards the cytosolic side of the membrane; null mutants have decreased net negative cell surface charge and localized accumulation of phosphatidic acid (PA) marker proteins; GFP-fusion protein expression is induced in response to MMS; null mutant can be complemented by the human seipin, BSCL2.


ensembl_gene_id: YCL005W-A
symbol: VMA9
gene_biotype: protein_coding
description:
  Vacuolar H+ ATPase subunit e of the V-ATPase V0 subcomplex; essential for vacuolar acidification; interacts with the V-ATPase assembly factor Vma21p in the ER; involved in V0 biogenesis.


ensembl_gene_id: YCL007C
symbol: YCL007C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein CWH36; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps verified ORF YCL005W-A; mutations in YCL007C were thought to confer sensitivity to calcofluor white, but this phenotype was later shown to be due to the defect in YCL005W-A.


ensembl_gene_id: YCL008C
symbol: STP22
gene_biotype: protein_coding
description:
  Suppressor protein STP22 of temperature-sensitive alpha-factor receptor and arginine permease; Component of the ESCRT-I complex; ESCRT-I is involved in ubiquitin-dependent sorting of proteins into the endosome; prevents polyubiquitination of the arrestin-related protein Rim8p, thereby directing its monoubiquitination by Rsp5p; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype;; Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.


ensembl_gene_id: YCL009C
symbol: ILV6
gene_biotype: protein_coding
description:
  Acetolactate synthase small subunit, mitochondrial; Regulatory subunit of acetolactate synthase; acetolactate synthase catalyzes the first step of branched-chain amino acid biosynthesis; enhances activity of the Ilv2p catalytic subunit, localizes to mitochondria.


ensembl_gene_id: YCL010C
symbol: SGF29
gene_biotype: protein_coding
description:
  SAGA-associated factor 29; Component of the HAT/Core module of the SAGA, SLIK, and ADA complexes; HAT/Core module also contains Gcn5p, Ngg1p, and Ada2p; binds methylated histone H3K4; involved in transcriptional regulation through SAGA and TBP recruitment to target promoters and H3 acetylation; Belongs to the SGF29 family.


ensembl_gene_id: YCL011C
symbol: GBP2
gene_biotype: protein_coding
description:
  Single-strand telomeric DNA-binding protein GBP2; Poly(A+) RNA-binding protein; key surveillance factor for the selective export of spliced mRNAs from the nucleus to the cytoplasm; preference for intron-containing genes; similar to Npl3p; also binds single-stranded telomeric repeat sequence in vitro; relocalizes to the cytosol in response to hypoxia; GBP2 has a paralog, HRB1, that arose from the whole genome duplication.


ensembl_gene_id: YCL012C
symbol: YCL012C
gene_biotype: protein_coding
description:
  UPF0357 protein YCL012C; Protein of unknown function; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively; orthologs are present in S. bayanus, S. paradoxus and Ashbya gossypii; YCL012C is not an essential gene; Belongs to the UPF0357 family.


ensembl_gene_id: YCL014W
symbol: BUD3
gene_biotype: protein_coding
description:
  Bud site selection protein 3; Guanine nucleotide exchange factor (GEF) for Cdc42p; activates Cdc42p in early G1, accounting for the first stage of biphasic activation, with Cdc24p accounting for the second stage in late G1; involved in the Cdc42p-mediated assembly of the axial landmark that dictates the site for the next round of budding, resulting in the axial budding pattern observed in haploids; localizes with septins to the bud neck contractile ring in mitosis.


ensembl_gene_id: YCL016C
symbol: DCC1
gene_biotype: protein_coding
description:
  Sister chromatid cohesion protein DCC1; Subunit of a complex with Ctf8p and Ctf18p; shares some components with Replication Factor C; required for sister chromatid cohesion and telomere length maintenance; Belongs to the DCC1 family.


ensembl_gene_id: YCL017C
symbol: NFS1
gene_biotype: protein_coding
description:
  Cysteine desulfurase, mitochondrial; Cysteine desulfurase; involved in iron-sulfur cluster (Fe/S) biogenesis and in thio-modification of mitochondrial and cytoplasmic tRNAs; essential protein located predominantly in mitochondria.


ensembl_gene_id: YCL018W
symbol: LEU2
gene_biotype: protein_coding
description:
  Beta-isopropylmalate dehydrogenase (IMDH); catalyzes the third step in the leucine biosynthesis pathway; can additionally catalyze the conversion of beta-ethylmalate into alpha-ketovalerate; Belongs to the isocitrate and isopropylmalate dehydrogenases family.


ensembl_gene_id: YCL022C
symbol: YCL022C
gene_biotype: protein_coding
description:
  Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps verified gene KCC4/YCL024W.


ensembl_gene_id: YCL023C
symbol: YCL023C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YCL023C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified ORF KCC4.


ensembl_gene_id: YCL024W
symbol: KCC4
gene_biotype: protein_coding
description:
  Probable serine/threonine-protein kinase KCC4; Protein kinase of the bud neck involved in the septin checkpoint; associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p; KCC4 has a paralog, GIN4, that arose from the whole genome duplication.


ensembl_gene_id: YCL025C
symbol: AGP1
gene_biotype: protein_coding
description:
  Low-affinity amino acid permease with broad substrate range; involved in uptake of asparagine, glutamine, and other amino acids; expression regulated by SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p); AGP1 has a paralog, GNP1, that arose from the whole genome duplication; Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.


ensembl_gene_id: YCL026C-A
symbol: FRM2
gene_biotype: protein_coding
description:
  Fatty acid repression mutant protein 2; Type II nitroreductase, using NADH as reductant; mutants are defective in fatty acid mediated repression of genes involved in fatty acid biosynthesis indicative of a role in lipid signaling; involved in the oxidative stress response; transcription induction by cadmium and selenite indicates a possible role in the metal stress response; expression induced in cells treated with the mycotoxin patulin.


ensembl_gene_id: YCL026C-B
symbol: HBN1
gene_biotype: protein_coding
description:
  Putative nitroreductase HBN1; Protein of unknown function; similar to bacterial nitroreductases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein becomes insoluble upon intracellular iron depletion; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YCL027W
symbol: FUS1
gene_biotype: protein_coding
description:
  Nuclear fusion protein FUS1; Membrane protein localized to the shmoo tip; required for cell fusion; expression regulated by mating pheromone; proposed to coordinate signaling, fusion, and polarization events required for fusion; potential Cdc28p substrate.


ensembl_gene_id: YCL029C
symbol: BIK1
gene_biotype: protein_coding
description:
  Nuclear fusion protein BIK1; Microtubule-associated protein; component of the interface between microtubules and kinetochore, involved in sister chromatid separation; essential in polyploid cells but not in haploid or diploid cells; ortholog of mammalian CLIP-170.


ensembl_gene_id: YCL030C
symbol: HIS4
gene_biotype: protein_coding
description:
  Histidine biosynthesis trifunctional protein; Multifunctional enzyme containing phosphoribosyl-ATP pyrophosphatase; phosphoribosyl-AMP cyclohydrolase, and histidinol dehydrogenase activities; catalyzes the second, third, ninth and tenth steps in histidine biosynthesis.


ensembl_gene_id: YCL031C
symbol: RRP7
gene_biotype: protein_coding
description:
  Ribosomal RNA-processing protein 7; Essential protein involved in rRNA processing and ribosome biogenesis; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YCL032W
symbol: STE50
gene_biotype: protein_coding
description:
  Adaptor protein for various signaling pathways; involved in mating response, invasive/filamentous growth, osmotolerance; acts as an adaptor that links G protein-associated Cdc42p-Ste20p complex to the effector Ste11p to modulate signal transduction.


ensembl_gene_id: YCL033C
symbol: MXR2
gene_biotype: protein_coding
description:
  Methionine-R-sulfoxide reductase; involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR1; involved in the regulation of lifespan.


ensembl_gene_id: YCL034W
symbol: LSB5
gene_biotype: protein_coding
description:
  Protein involved in membrane-trafficking events at plasma membrane; interacts with actin regulators Sla1p and Las17p, ubiquitin, Arf3p to couple actin dynamics to membrane trafficking processes; similar structure to GGA family of proteins with N-terminal VHS domain and GAT domain; binds Las17p, which is homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly, actin polymerization; may mediate disassembly of Pan1 complex from endocytic coat; Belongs to the LSB5 family.


ensembl_gene_id: YCL035C
symbol: GRX1
gene_biotype: protein_coding
description:
  Glutaredoxin-1; Glutathione-dependent disulfide oxidoreductase; hydroperoxide and superoxide-radical responsive, heat-stable, with active site cysteine pair; protects cells from oxidative damage; GRX1 has a paralog, GRX2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YCL036W
symbol: GFD2
gene_biotype: protein_coding
description:
  Good for full DBP5 activity protein 2; Protein of unknown function; identified as a high-copy suppressor of a dbp5 mutation; GFD2 has a paralog, YDR514C, that arose from the whole genome duplication.


ensembl_gene_id: YCL037C
symbol: SRO9
gene_biotype: protein_coding
description:
  Cytoplasmic RNA-binding protein; shuttles between nucleus and cytoplasm and is exported from the nucleus in an mRNA export-dependent manner; associates with translating ribosomes; involved in heme regulation of Hap1p as a component of the HMC complex, also involved in the organization of actin filaments; contains a La motif; SRO9 has a paralog, SLF1, that arose from the whole genome duplication.


ensembl_gene_id: YCL038C
symbol: ATG22
gene_biotype: protein_coding
description:
  Autophagy-related protein 22; Vacuolar integral membrane protein required for efflux of amino acids; required for efflux of amino acids during autophagic body breakdown in the vacuole; null mutation causes a gradual loss of viability during starvation; Belongs to the ATG22 family.


ensembl_gene_id: YCL039W
symbol: GID7
gene_biotype: protein_coding
description:
  Glucose-induced degradation protein 7; Subunit of GID Complex that binds directly to central component Vid30p; GID complex is involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; Gid7p contains six WD40 repeats; computational analysis suggests that Gid7p and Moh1p have similar functions.


ensembl_gene_id: YCL040W
symbol: GLK1
gene_biotype: protein_coding
description:
  Glucokinase-1; Glucokinase; catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism; one of three glucose phosphorylating enzymes; expression regulated by non-fermentable carbon sources; GLK1 has a paralog, EMI2, that arose from the whole genome duplication; Belongs to the hexokinase family.


ensembl_gene_id: YCL041C
symbol: YCL041C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YCL041C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps both the verified gene PDI1/YCL043C and the uncharacterized gene YCL042W.


ensembl_gene_id: YCL043C
symbol: PDI1
gene_biotype: protein_coding
description:
  Protein disulfide isomerase; multifunctional oxidoreductase of the ER lumen, essential for disulfide bond formation in secretory and cell-surface proteins, processing of non-native disulfide bonds; Ero1p activator; complexes with exomannosidase, Mnl1p to facilitate the recognition of misfolded glycoproteins and the trimming of glycan Man8GlcNAc2 to Man7GlcNAc2 on substrates, thereby accelerating ERAD; PDI1 has a paralog, EUG1, that arose from the whole genome duplication.


ensembl_gene_id: YCL044C
symbol: MGR1
gene_biotype: protein_coding
description:
  Subunit of the mitochondrial (mt) i-AAA protease supercomplex; i-AAA degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr3p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA.


ensembl_gene_id: YCL045C
symbol: EMC1
gene_biotype: protein_coding
description:
  Member of conserved endoplasmic reticulum membrane complex; involved in efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; interacts with Gal80p; homologous to worm H17B01.4/EMC-1, fly CG2943, and human KIAA0090; Belongs to the EMC1 family.


ensembl_gene_id: YCL046W
symbol: YCL046W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YCL046W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YCL045C.


ensembl_gene_id: YCL047C
symbol: POF1
gene_biotype: protein_coding
description:
  Nicotinamide mononucleotide-specific adenylyltransferase (NMNAT); catalyzes the conversion of nicotinamide mononucleotide (NMN) to nicotinamide adenine dinucleotide (NAD+); role in the nicotinamide riboside (NR) salvage pathway of NAD+ biosynthesis; involved in NR and NAD+ homeostasis; ATPase involved in protein quality control and filamentation pathways; interacts physically with Kss1p and suppresses the filamentation defect of a kss1 deletion.


ensembl_gene_id: YCL048W
symbol: SPS22
gene_biotype: protein_coding
description:
  Protein of unknown function; SPS22 has a paralog, SPS2, that arose from the whole genome duplication; redundant with Sps2p for the organization of the beta-glucan layer of the spore wall; Belongs to the SPS2 family.


ensembl_gene_id: YCL048W-A
symbol: YCL048W-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YCL048W-A; Putative protein of unknown function; SWAT-GFP and mCherry fusion proteins localize to the cell periphery and vacuole; YCL048W-A has a paralog, YDR524C-B, that arose from the whole genome duplication.


ensembl_gene_id: YCL049C
symbol: YCL049C
gene_biotype: protein_coding
description:
  Uncharacterized protein YCL049C; Protein of unknown function; localizes to membrane fraction; YCL049C is not an essential gene.


ensembl_gene_id: YCL050C
symbol: APA1
gene_biotype: protein_coding
description:
  AP4A phosphorylase; bifunctional diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase and ADP sulfurylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; catalyzes phosphorolysis of dinucleoside oligophosphates, cleaving substrates' alpha/beta-anhydride bond and introducing Pi into the beta-position of the corresponding NDP formed; protein abundance increases under DNA replication stress; APA1 has a paralog, APA2, that arose from the whole genome duplication; Belongs to the ATP adenylyltransferase family.


ensembl_gene_id: YCL051W
symbol: LRE1
gene_biotype: protein_coding
description:
  Laminarase-resistance protein LRE1; Protein involved in control of cell wall structure and stress response; direct inhibitor of the nuclear Dbf2 related (NDR) kinase Cbk1p-Mob2p; overproduction confers resistance to cell-wall degrading enzymes; exhibits genetic interactions with genes involved in the cell wall integrity pathway; LRE1 has a paralog, HLR1, that arose from the whole genome duplication.


ensembl_gene_id: YCL052C
symbol: PBN1
gene_biotype: protein_coding
description:
  Protein PBN1; Component of glycosylphosphatidylinositol-mannosyltransferase I; essential component; required for the autocatalytic post-translational processing of the protease B precursor Prb1p; localizes to ER in lumenal orientation; homolog of mammalian PIG-X.


ensembl_gene_id: YCL054W
symbol: SPB1
gene_biotype: protein_coding
description:
  27S pre-rRNA (guanosine(2922)-2'-O)-methyltransferase; AdoMet-dependent methyltransferase; involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the tRNA docking site of the large subunit rRNA and in the absence of snR52, U2921; suppressor of PAB1 mutants.


ensembl_gene_id: YCL054W-A
symbol: RDT1
gene_biotype: protein_coding
description:
  Uncharacterized protein RDT1; Short open reading frame, shows evidence of translation; may be new protein-coding gene that originated de novo from noncoding sequence; same allele found in at least 33 other S. cerevisiae strains; at least 3 strains have a second allele with three nucleotide substitutions leading to two amino acid differences.


ensembl_gene_id: YCL055W
symbol: KAR4
gene_biotype: protein_coding
description:
  Karyogamy protein KAR4; Transcription factor required for response to pheromones; also required during meiosis; exists in two forms, a slower-migrating form more abundant during vegetative growth and a faster-migrating form induced by pheromone.


ensembl_gene_id: YCL056C
symbol: PEX34
gene_biotype: protein_coding
description:
  Protein that regulates peroxisome populations; peroxisomal integral membrane protein; interacts with Pex11p, Pex25p, and Pex27p to control both constitutive peroxisome division and peroxisome morphology and abundance during peroxisome proliferation.


ensembl_gene_id: YCL057C-A
symbol: MIC10
gene_biotype: protein_coding
description:
  Conserved component of the MICOS complex; MICOS (formerly MINOS or MitOS) is a mitochondrial inner membrane complex that extends into the intermembrane space and has a role in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane; forms a subcomplex with Mic12p and Mic27p whose assembly and stability requires cardiolipin; homo-oligomers cause membrane bending; ortholog of human MINOS1.


ensembl_gene_id: YCL057W
symbol: PRD1
gene_biotype: protein_coding
description:
  Saccharolysin; Zinc metalloendopeptidase; found in the cytoplasm and intermembrane space of mitochondria; with Cym1p, involved in degradation of mitochondrial proteins and of presequence peptides cleaved from imported proteins; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YCL058C
symbol: FYV5
gene_biotype: protein_coding
description:
  Protein involved in regulation of the mating pathway; binds with Matalpha2p to promoters of haploid-specific genes; required for survival upon exposure to K1 killer toxin; involved in ion homeostasis.


ensembl_gene_id: YCL058W-A
symbol: ADF1
gene_biotype: protein_coding
description:
  Antisense of depressing factor protein 1; Transcriptional repressor encoded by the FYV5 antisense strand; negatively regulates transcription of FYV5 by binding to the promoter on the sense strand.


ensembl_gene_id: YCL059C
symbol: KRR1
gene_biotype: protein_coding
description:
  KRR1 small subunit processome component; Nucleolar protein required for rRNA synthesis and ribosomal assembly; required for the synthesis of 18S rRNA and for the assembly of 40S ribosomal subunit; essential gene; Belongs to the KRR1 family.


ensembl_gene_id: YCL061C
symbol: MRC1
gene_biotype: protein_coding
description:
  S-phase checkpoint protein required for DNA replication; couples DNA helicase and polymerase; interacts with and stabilizes Pol2p at stalled replication forks during stress, where it forms a pausing complex with Tof1p and is phosphorylated by Mec1p; defines a novel S-phase checkpoint with Hog1p that coordinates DNA replication and transcription upon osmostress; protects uncapped telomeres; Dia2p-dependent degradation mediates checkpoint recovery; mammalian claspin homolog.


ensembl_gene_id: YCL063W
symbol: VAC17
gene_biotype: protein_coding
description:
  Vacuole-related protein 17; Phosphoprotein involved in vacuole inheritance; degraded in late M phase of the cell cycle; acts as a vacuole-specific receptor for myosin Myo2p; involved in regulation of asymmetric inheritance of aggregated/misfolded proteins and age reset; Belongs to the VAC17 family.


ensembl_gene_id: YCL064C
symbol: CHA1
gene_biotype: protein_coding
description:
  Catabolic L-serine/threonine dehydratase; Catabolic L-serine (L-threonine) deaminase; catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine; Belongs to the serine/threonine dehydratase family.


ensembl_gene_id: YCL065W
symbol: YCL065W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YCL065W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps HMLALPHA1.


ensembl_gene_id: YCL066W
symbol: HMLALPHA1
gene_biotype: protein_coding
description:
  Silenced copy of ALPHA1 at HML; ALPHA1 encodes a transcriptional coactivator involved in the regulation of mating-type alpha-specific gene expression.


ensembl_gene_id: YCL067C
symbol: HMLALPHA2
gene_biotype: protein_coding
description:
  Silenced copy of ALPHA2 at HML; homeobox-domain protein that associates with Mcm1p in haploid cells to repress a-specific gene expression and interacts with a1p in diploid cells to repress haploid-specific gene expression.


ensembl_gene_id: YCL069W
symbol: VBA3
gene_biotype: protein_coding
description:
  Permease of basic amino acids in the vacuolar membrane; VBA3 has a paralog, VBA5, that arose from a segmental duplication; Belongs to the major facilitator superfamily.


ensembl_gene_id: YCL073C
symbol: GEX1
gene_biotype: protein_coding
description:
  Glutathione exchanger 1; Proton:glutathione antiporter; localized to the vacuolar and plasma membranes; imports glutathione from the vacuole and exports it through the plasma membrane; has a role in resistance to oxidative stress and modulation of the PKA pathway; GEX1 has a paralog, GEX2, that arose from a segmental duplication.


ensembl_gene_id: YCL076W
symbol: YCL076W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YCL076W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YCR001W
symbol: YCR001W
gene_biotype: protein_coding
description:
  Uncharacterized protein YCR001W; Putative protein of unknown function; conserved among S. cerevisiae strains; YCR001W is not an essential gene.


ensembl_gene_id: YCR002C
symbol: CDC10
gene_biotype: protein_coding
description:
  Cell division control protein 10; Component of the septin ring, required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells; N-terminus interacts with phosphatidylinositol-4,5-bisphosphate; protein abundance increases under DNA damage stress.


ensembl_gene_id: YCR003W
symbol: MRPL32
gene_biotype: protein_coding
description:
  Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YCR004C
symbol: YCP4
gene_biotype: protein_coding
description:
  Flavoprotein-like protein YCP4; Protein of unknown function; has sequence and structural similarity to flavodoxins; predicted to be palmitoylated; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies.


ensembl_gene_id: YCR005C
symbol: CIT2
gene_biotype: protein_coding
description:
  Citrate synthase, peroxisomal isozyme involved in glyoxylate cycle; catalyzes condensation of acetyl coenzyme A and oxaloacetate to form citrate; expression is controlled by Rtg1p and Rtg2p transcription factors; SCF-Ucc1 regulates level of Cit2p to maintain citrate homeostasis; oxaloacetate-dependent positive feedback loop inhibits Cit2p ubiquitination; CIT2 has a paralog, CIT1, that arose from the whole genome duplication.


ensembl_gene_id: YCR006C
symbol: YCR006C
gene_biotype: protein_coding
description:
  Uncharacterized protein YCR006C; Putative protein of unknown function; conserved among S. cerevisiae strains; YCR006C is not an essential gene.


ensembl_gene_id: YCR007C
symbol: YCR007C
gene_biotype: protein_coding
description:
  DUP240 protein YCR007C; Putative integral membrane protein; member of DUP240 gene family; SWAT-GFP and mCherry fusion proteins localize to the cell periphery and vacuole; YCR007C is not an essential gene.


ensembl_gene_id: YCR008W
symbol: SAT4
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase HAL4/SAT4; Ser/Thr protein kinase involved in salt tolerance; funtions in regulation of Trk1p-Trk2p potassium transporter; overexpression affects the Fe-S and lipoamide containing proteins in the mitochondrion; required for lipoylation of Lat1p, Kgd2p and Gcv3p; partially redundant with Hal5p; has similarity to Npr1p; localizes to the cytoplasm and mitochondrion.


ensembl_gene_id: YCR009C
symbol: RVS161
gene_biotype: protein_coding
description:
  Reduced viability upon starvation protein 161; Amphiphysin-like lipid raft protein; N-BAR domain protein that interacts with Rvs167p and regulates polarization of the actin cytoskeleton, endocytosis, cell polarity, cell fusion and viability following starvation or osmotic stress.


ensembl_gene_id: YCR010C
symbol: ADY2
gene_biotype: protein_coding
description:
  Accumulation of dyads protein 2; Acetate transporter required for normal sporulation; phosphorylated in mitochondria; ADY2 has a paralog, ATO2, that arose from the whole genome duplication.


ensembl_gene_id: YCR011C
symbol: ADP1
gene_biotype: protein_coding
description:
  Putative ATP-dependent permease of the ABC transporter family; Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.


ensembl_gene_id: YCR012W
symbol: PGK1
gene_biotype: protein_coding
description:
  3-phosphoglycerate kinase; catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis.


ensembl_gene_id: YCR013C
symbol: YCR013C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YCR013C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; transcription of both YCR013C and the overlapping essential gene PGK1 is reduced in a gcr1 null mutant.


ensembl_gene_id: YCR014C
symbol: POL4
gene_biotype: protein_coding
description:
  DNA polymerase IV; undergoes pair-wise interactions with Dnl4p-Lif1p and Rad27p to mediate repair of DNA double-strand breaks by non-homologous end joining (NHEJ); homologous to mammalian DNA polymerase beta.


ensembl_gene_id: YCR015C
symbol: CTO1
gene_biotype: protein_coding
description:
  Protein required for cold tolerance; involved in phosphate uptake; YCR015C is not an essential gene.


ensembl_gene_id: YCR016W
symbol: YCR016W
gene_biotype: protein_coding
description:
  Uncharacterized protein YCR016W; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus and nucleus; predicted to be involved in ribosome biogenesis.


ensembl_gene_id: YCR017C
symbol: CWH43
gene_biotype: protein_coding
description:
  Protein CWH43; GPI lipid remodelase; responsible for introducing ceramides into GPI anchors having a C26:0 fatty acid in sn-2 of the glycerol moiety; can also use lyso-GPI protein anchors and various base resistant lipids as substrates; contains 14-16 transmembrane segments and several putative glycosylation and phosphorylation sites; null mutation is synthetically lethal with pkc1 deletion; In the C-terminal section; belongs to the PGAP2IP family.


ensembl_gene_id: YCR018C
symbol: SRD1
gene_biotype: protein_coding
description:
  Pre-rRNA-processing protein SRD1; Protein involved in the processing of pre-rRNA to mature rRNA; contains a C2/C2 zinc finger motif; srd1 mutation suppresses defects caused by the rrp1-1 mutation.


ensembl_gene_id: YCR020C
symbol: PET18
gene_biotype: protein_coding
description:
  Protein of unknown function; has weak similarity to proteins involved in thiamin metabolism; expression is induced in the absence of thiamin.


ensembl_gene_id: YCR020C-A
symbol: MAK31
gene_biotype: protein_coding
description:
  N-alpha-acetyltransferase 38, NatC auxiliary subunit; Non-catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus; member of the Sm protein family.


ensembl_gene_id: YCR020W-B
symbol: HTL1
gene_biotype: protein_coding
description:
  High temperature lethal protein 1; Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance.


ensembl_gene_id: YCR021C
symbol: HSP30
gene_biotype: protein_coding
description:
  30 kDa heat shock protein; Negative regulator of the H(+)-ATPase Pma1p; stress-responsive protein; hydrophobic plasma membrane localized; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase; Belongs to the archaeal/bacterial/fungal opsin family.


ensembl_gene_id: YCR022C
symbol: YCR022C
gene_biotype: protein_coding
description:
  Uncharacterized protein YCR022C; Putative protein of unknown function; conserved among S. cerevisiae strains; YCR022C is not an essential gene.


ensembl_gene_id: YCR023C
symbol: YCR023C
gene_biotype: protein_coding
description:
  Vacuolar membrane protein of unknown function; member of the multidrug resistance family; YCR023C is not an essential gene.


ensembl_gene_id: YCR024C-A
symbol: PMP1
gene_biotype: protein_coding
description:
  Regulatory subunit for the plasma membrane H(+)-ATPase Pma1p; small single-membrane span proteolipid; forms unique helix and positively charged cytoplasmic domain that is able to specifically segregate phosphatidylserines; PMP1 has a paralog, PMP2, that arose from the whole genome duplication.


ensembl_gene_id: YCR024C-B
symbol: YCR024C-B
gene_biotype: protein_coding
description:
  Uncharacterized protein YCR024C-B; Putative protein of unknown function; identified by expression profiling and mass spectrometry.


ensembl_gene_id: YCR025C
symbol: YCR025C
gene_biotype: protein_coding
description:
  Uncharacterized protein YCR025C; Putative protein of unknown function; conserved across S. cerevisiae strains; YCR025C is not an essential gene.


ensembl_gene_id: YCR026C
symbol: NPP1
gene_biotype: protein_coding
description:
  Ectonucleotide pyrophosphatase/phosphodiesterase 1; Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp2p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; involved in spore wall assembly; NPP1 has a paralog, NPP2, that arose from the whole genome duplication, and an npp1 npp2 double mutant exhibits reduced dityrosine fluorescence relative to the single mutants.


ensembl_gene_id: YCR027C
symbol: RHB1
gene_biotype: protein_coding
description:
  Rheb-like protein RHB1; Putative Rheb-related GTPase; involved in regulating canavanine resistance and arginine uptake; member of the Ras superfamily of G-proteins.


ensembl_gene_id: YCR028C
symbol: FEN2
gene_biotype: protein_coding
description:
  Pantothenate transporter FEN2; Plasma membrane H+-pantothenate symporter; confers sensitivity to the antifungal agent fenpropimorph; relocalizes from vacuole to cytoplasm upon DNA replication stress.


ensembl_gene_id: YCR028C-A
symbol: RIM1
gene_biotype: protein_coding
description:
  ssDNA-binding protein essential for mitochondrial genome maintenance; involved in mitochondrial DNA replication; stimulates utilization by Mip1p DNA polymerase of RNA primers synthesized by Rpo41p.


ensembl_gene_id: YCR030C
symbol: SYP1
gene_biotype: protein_coding
description:
  Suppressor of yeast profilin deletion; Negative regulator of WASP-Arp23 complex; involved in endocytic site formation; directly inhibits Las17p stimulation of Arp23 complex-mediated actin assembly in vitro; may regulate assembly and disassembly of the septin ring; colocalizes and interacts with septin subunits; potential role in actin cytoskeletal organization.


ensembl_gene_id: YCR031C
symbol: RPS14A
gene_biotype: protein_coding
description:
  Protein component of the small (40S) ribosomal subunit; required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; homologous to mammalian ribosomal protein S14 and bacterial S11; RPS14A has a paralog, RPS14B, that arose from the whole genome duplication.


ensembl_gene_id: YCR032W
symbol: BPH1
gene_biotype: protein_coding
description:
  Protein homologous to Chediak-Higashi syndrome and Beige proteins; both of which are implicated in disease syndromes in human and mouse, respectively, due to defective lysosomal trafficking; mutant phenotype and genetic interactions suggest a role in protein sorting.


ensembl_gene_id: YCR033W
symbol: SNT1
gene_biotype: protein_coding
description:
  Probable DNA-binding protein SNT1; Subunit of the Set3C deacetylase complex; interacts directly with the Set3C subunit, Sif2p; putative DNA-binding protein; mutant has increased aneuploidy tolerance; relocalizes to the cytosol in response to hypoxia.


ensembl_gene_id: YCR034W
symbol: ELO2
gene_biotype: protein_coding
description:
  Elongation of fatty acids protein 2; Fatty acid elongase, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathway; ELO2 has a paralog, ELO1, that arose from the whole genome duplication; lethality of the elo2 elo3 double null mutation is functionally complemented by human ELOVL1 and weakly complemented by human ELOVL3 or ELOV7.


ensembl_gene_id: YCR035C
symbol: RRP43
gene_biotype: protein_coding
description:
  Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp43p (OIP2, EXOSC8); protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YCR037C
symbol: PHO87
gene_biotype: protein_coding
description:
  Low-affinity inorganic phosphate (Pi) transporter; acts upstream of Pho81p in regulation of the PHO pathway; expression is independent of Pi concentration and Pho4p activity; contains 12 membrane-spanning segments; PHO87 has a paralog, PHO90, that arose from the whole genome duplication.


ensembl_gene_id: YCR038C
symbol: BUD5
gene_biotype: protein_coding
description:
  Bud site selection protein 5; GTP/GDP exchange factor for Rsr1p (Bud1p); required for both axial and bipolar budding patterns; mutants exhibit random budding in all cell types.


ensembl_gene_id: YCR038W-A
symbol: YCR038W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YCR038W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified gene BUD5/YCR038C; identified by homology with hemiascomycetous yeast species.


ensembl_gene_id: YCR039C
symbol: MATALPHA2
gene_biotype: protein_coding
description:
  Homeobox-domain protein; with Mcm1p, represses a-specific genes in haploids; acts with A1p to repress transcription of haploid-specific genes in diploids; one of two genes encoded by the MATalpha mating type cassette.


ensembl_gene_id: YCR040W
symbol: MATALPHA1
gene_biotype: protein_coding
description:
  Transcriptional co-activator that regulates mating-type-specific genes; targets the transcription factor Mcm1p to the promoters of alpha-specific genes; one of two genes encoded by the MATalpha mating type cassette.


ensembl_gene_id: YCR041W
symbol: YCR041W
gene_biotype: protein_coding
description:
  Uncharacterized protein YCR041W; Protein of unknown function; overexpression suppresses the high-frequency loss of mini-chromosomes, probably by increasing the rate of proper chromosome segregation; translated gene product of YCR041W, but not its transcript, is responsible for suppression; suppression ability of YCR041W is completely dependent on silencing protein Sir4p.


ensembl_gene_id: YCR043C
symbol: YCR043C
gene_biotype: protein_coding
description:
  Uncharacterized protein YCR043C; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi apparatus; YCR043C is not an essential gene.


ensembl_gene_id: YCR044C
symbol: PER1
gene_biotype: protein_coding
description:
  Protein of the endoplasmic reticulum; required for GPI-phospholipase A2 activity that remodels the GPI anchor as a prerequisite for association of GPI-anchored proteins with lipid rafts; functionally complemented by human ortholog PERLD1.


ensembl_gene_id: YCR045C
symbol: RRT12
gene_biotype: protein_coding
description:
  Subtilase-type proteinase RRT12; Probable subtilisin-family protease; role in formation of the dityrosine layer of spore walls; localizes to the spore wall and also the nuclear envelope and ER region in mature spores.


ensembl_gene_id: YCR045W-A
symbol: YCR045W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YCR045W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps with YCR045C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching.


ensembl_gene_id: YCR046C
symbol: IMG1
gene_biotype: protein_coding
description:
  Mitochondrial ribosomal protein of the large subunit; required for respiration and for maintenance of the mitochondrial genome.


ensembl_gene_id: YCR047C
symbol: BUD23
gene_biotype: protein_coding
description:
  Methyltransferase that methylates residue G1575 of 18S rRNA; required for rRNA processing and nuclear export of 40S ribosomal subunits independently of methylation activity; diploid mutant displays random budding pattern; functional homolog of human WBSCR22; Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.


ensembl_gene_id: YCR047W-A
symbol: YCR047W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YCR047W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps with YCR047C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching.


ensembl_gene_id: YCR048W
symbol: ARE1
gene_biotype: protein_coding
description:
  Sterol O-acyltransferase 1; Acyl-CoA:sterol acyltransferase; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the absence of oxygen; ARE1 has a paralog, ARE2, that arose from the whole genome duplication.


ensembl_gene_id: YCR049C
symbol: YCR049C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YCR049C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YCR050C
symbol: YCR050C
gene_biotype: protein_coding
description:
  Uncharacterized protein YCR050C; Non-essential protein of unknown function; deletion mutant is synthetically sick or lethal with alpha-synuclein.


ensembl_gene_id: YCR051W
symbol: YCR051W
gene_biotype: protein_coding
description:
  Ankyrin repeat-containing protein YCR051W; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; contains ankyrin (Ank) repeats; YCR051W is not an essential gene.


ensembl_gene_id: YCR052W
symbol: RSC6
gene_biotype: protein_coding
description:
  Component of the RSC chromatin remodeling complex; essential for mitotic growth; RSC6 has a paralog, SNF12, that arose from the whole genome duplication.


ensembl_gene_id: YCR053W
symbol: THR4
gene_biotype: protein_coding
description:
  Threonine synthase; conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway.


ensembl_gene_id: YCR054C
symbol: CTR86
gene_biotype: protein_coding
description:
  Copper transport protein 86; Essential protein of unknown function; with orthologs in Ashbya gossypii and Candida albicans; similar to human ATXN10, mutations in which cause spinocerebellar ataxia type 10; codon usage corresponds to that observed for yeast genes expressed at low levels; relative distribution to the nucleus increases upon DNA replication stress.


ensembl_gene_id: YCR057C
symbol: PWP2
gene_biotype: protein_coding
description:
  Periodic tryptophan protein 2; Conserved 90S pre-ribosomal component; essential for proper endonucleolytic cleavage of the 35 S rRNA precursor at A0, A1, and A2 sites; contains eight WD-repeats; PWP2 deletion leads to defects in cell cycle and bud morphogenesis.


ensembl_gene_id: YCR059C
symbol: YIH1
gene_biotype: protein_coding
description:
  Protein IMPACT homolog; Negative regulator of eIF2 kinase Gcn2p; competes with Gcn2p for binding to Gcn1p; may contribute to regulation of translation in response to starvation via regulation of Gcn2p; binds to monomeric actin and to ribosomes and polyribosomes; ortholog of mammalian IMPACT; Belongs to the IMPACT family.


ensembl_gene_id: YCR060W
symbol: TAH1
gene_biotype: protein_coding
description:
  TPR repeat-containing protein associated with Hsp90; Component of conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly of large protein complexes such as box C/D snoRNPs and RNA polymerase II; contains a single TPR domain with at least two TPR motifs; plays a role in determining prion variants.


ensembl_gene_id: YCR061W
symbol: YCR061W
gene_biotype: protein_coding
description:
  Uncharacterized membrane protein YCR061W; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; induced by treatment with 8-methoxypsoralen and UVA irradiation.


ensembl_gene_id: YCR063W
symbol: BUD31
gene_biotype: protein_coding
description:
  Pre-mRNA-splicing factor BUD31; Component of the SF3b subcomplex of the U2 snRNP; increases efficiency of first and second step pre-mRNA splicing; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; facilitates passage through G1/S Start, but is not required for G2/M transition or exit from mitosis.


ensembl_gene_id: YCR064C
symbol: YCR064C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YCR064C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene BUD31.


ensembl_gene_id: YCR065W
symbol: HCM1
gene_biotype: protein_coding
description:
  Forkhead transcription factor; drives S-phase activation of genes involved in chromosome segregation, spindle dynamics, budding; also activates genes involved in respiration, use of alternative energy sources (like proline), NAD synthesis, oxidative stress resistance; key factor in early adaptation to nutrient deficiency and diauxic shift; suppressor of calmodulin mutants with specific SPB assembly defects; ortholog of C. elegans lifespan regulator PHA-4.


ensembl_gene_id: YCR066W
symbol: RAD18
gene_biotype: protein_coding
description:
  Postreplication repair E3 ubiquitin-protein ligase RAD18; E3 ubiquitin ligase; forms heterodimer with Rad6p to monoubiquitinate PCNA-K164; heterodimer binds single-stranded DNA and has single-stranded DNA dependent ATPase activity; required for postreplication repair; SUMO-targeted ubiquitin ligase (STUbl) that contains a SUMO-interacting motif (SIM) which stimulates its ubiquitin ligase activity towards the sumoylated form of PCNA.


ensembl_gene_id: YCR067C
symbol: SED4
gene_biotype: protein_coding
description:
  Putative guanine nucleotide-exchange factor SED4; Integral ER membrane protein that stimulates Sar1p GTPase activity; involved in COPII vesicle budding through disassociation of coat proteins from membranes onto liposomes; binds Sec16p; SED4 has a paralog, SEC12, that arose from the whole genome duplication; Belongs to the WD repeat SEC12 family.


ensembl_gene_id: YCR068W
symbol: ATG15
gene_biotype: protein_coding
description:
  Putative lipase ATG15; Phospholipase; preferentially hydrolyses phosphatidylserine, with minor activity against cardiolipin and phosphatidylethanolamine; required for lysis of autophagic and CVT bodies; targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway; required for the maintenance of lipid droplet quantity after the diauxic shift; regulates lipolysis; expression regulated by Yap1p during autophagy; Belongs to the AB hydrolase superfamily. Lipase family.


ensembl_gene_id: YCR069W
symbol: CPR4
gene_biotype: protein_coding
description:
  Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway; CPR4 has a paralog, CPR8, that arose from the whole genome duplication.


ensembl_gene_id: YCR071C
symbol: IMG2
gene_biotype: protein_coding
description:
  Mitochondrial ribosomal protein of the large subunit; conserved in metazoa, with similarity to human mitochondrial ribosomal protein MRPL49.


ensembl_gene_id: YCR072C
symbol: RSA4
gene_biotype: protein_coding
description:
  WD-repeat protein involved in ribosome biogenesis; may interact with ribosomes; required for maturation and efficient intra-nuclear transport or pre-60S ribosomal subunits, localizes to the nucleolus; Belongs to the NLE1/RSA4 family.


ensembl_gene_id: YCR073C
symbol: SSK22
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase SSK22; MAP kinase kinase kinase of HOG1 mitogen-activated signaling pathway; functionally redundant with Ssk2p; interacts with and is activated by Ssk1p; phosphorylates Pbs2p; SSK22 has a paralog, SSK2, that arose from the whole genome duplication.


ensembl_gene_id: YCR073W-A
symbol: SOL2
gene_biotype: protein_coding
description:
  6-phosphogluconolactonase-like protein 2; Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol3p and Sol4p; SOL2 has a paralog, SOL1, that arose from the whole genome duplication.


ensembl_gene_id: YCR075C
symbol: ERS1
gene_biotype: protein_coding
description:
  Protein involved in cystine transport; localizes to the vacuole, plasma membrane and endosome; similarity to human cystinosin, a H(+)-driven transporter involved in L-cystine export from lysosomes and implicated in the disease cystinosis; contains seven transmembrane domains; mutation is functionally complemented by human CTNS.


ensembl_gene_id: YCR075W-A
symbol: EGO2
gene_biotype: protein_coding
description:
  Uncharacterized protein YCR075W-A; Component of the EGO and GSE complexes; identified by homology to Ashbya gossypii; YCR075W-A has a paralog, YNR034W-A, that arose from the whole genome duplication.


ensembl_gene_id: YCR076C
symbol: FUB1
gene_biotype: protein_coding
description:
  Silencing boundary-establishment protein FUB1; Proteasome-binding protein; interacts physically with multiple subunits of the 20S proteasome and genetically with genes encoding 20S core particle and 19S regulatory particle subunits; exhibits boundary activity which blocks the propagation of heterochromatic silencing; contains a PI31 proteasome regulator domain and sequence similarity with human PSMF1, a proteasome inhibitor; not an essential gene.


ensembl_gene_id: YCR077C
symbol: PAT1
gene_biotype: protein_coding
description:
  DNA topoisomerase 2-associated protein PAT1; Deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; associated with topoisomerase II; binds to mRNAs under glucose starvation, most often in the 3' UTR; functionally linked to Pab1p; forms cytoplasmic foci upon DNA replication stress; phosphorylation by PKA inhibits P body foci formation; Belongs to the PAT1 family.


ensembl_gene_id: YCR079W
symbol: PTC6
gene_biotype: protein_coding
description:
  [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial; Mitochondrial type 2C protein phosphatase (PP2C); has similarity to mammalian PP1Ks; involved in mitophagy; null mutant is sensitive to rapamycin and has decreased phosphorylation of the Pda1 subunit of pyruvate dehydrogenase.


ensembl_gene_id: YCR081C-A
symbol: YCR081C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YCR081C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps with SRB8/YCR081W; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching.


ensembl_gene_id: YCR081W
symbol: SRB8
gene_biotype: protein_coding
description:
  Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; involved in glucose repression.


ensembl_gene_id: YCR082W
symbol: AHC2
gene_biotype: protein_coding
description:
  Component of the ADA histone acetyltransferase complex; Ahc2p and Ahc1p are unique to the ADA complex and not shared with the related SAGA and SLIK complexes; may tether Ahc1p to the complex.


ensembl_gene_id: YCR083W
symbol: TRX3
gene_biotype: protein_coding
description:
  Mitochondrial thioredoxin; highly conserved oxidoreductase required to maintain the redox homeostasis of the cell, forms the mitochondrial thioredoxin system with Trr2p, redox state is maintained by both Trr2p and Glr1p.


ensembl_gene_id: YCR084C
symbol: TUP1
gene_biotype: protein_coding
description:
  General transcriptional corepressor TUP1; General repressor of transcription; forms complex with Cyc8p, involved in the establishment of repressive chromatin structure through interactions with histones H3 and H4, appears to enhance expression of some genes.


ensembl_gene_id: YCR085W
symbol: YCR085W
gene_biotype: protein_coding
description:
  Uncharacterized protein YCR085W; Putative protein of unknown function; conserved among S. cerevisiae strains; YCR085W is not an essential gene.


ensembl_gene_id: YCR086W
symbol: CSM1
gene_biotype: protein_coding
description:
  Monopolin complex subunit CSM1; Nucleolar protein that mediates homolog segregation during meiosis I; forms a complex with Lrs4p and then Mam1p at kinetochores; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation.


ensembl_gene_id: YCR087C-A
symbol: YCR087C-A
gene_biotype: protein_coding
description:
  UPF0743 protein YCR087C-A; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YCR087C-A is not an essential gene; Belongs to the UPF0743 family.


ensembl_gene_id: YCR087W
symbol: YCR087W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YCR087W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YCR087C-A; YCR087W is not an essential gene.


ensembl_gene_id: YCR088W
symbol: ABP1
gene_biotype: protein_coding
description:
  Actin-binding protein of the cortical actin cytoskeleton; important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization; inhibits barbed-end actin filament elongation; phosphorylation within its Proline-Rich Regio, mediated by Cdc28p and Pho85p, protects Abp1p from proteolysis mediated by its own PEST sequences; mammalian homolog of HIP-55 (hematopoietic progenitor kinase 1 [HPK1]-interacting protein of 55 kDa).


ensembl_gene_id: YCR089W
symbol: FIG2
gene_biotype: protein_coding
description:
  Factor-induced gene 2 protein; Cell wall adhesin, expressed specifically during mating; may be involved in maintenance of cell wall integrity during mating; FIG2 has a paralog, AGA1, that arose from the whole genome duplication.


ensembl_gene_id: YCR090C
symbol: YCR090C
gene_biotype: protein_coding
description:
  UPF0587 protein YCR090C; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YCR090C is not an essential gene; Belongs to the UPF0587 family.


ensembl_gene_id: YCR091W
symbol: KIN82
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase KIN82; Putative serine/threonine protein kinase; implicated in the regulation of phospholipid asymmetry through the activation of phospholipid translocases (flippases); involved in the phosphorylation of upstream inhibitory kinase Ypk1p along with Fpk1p; has a redundant role in the cellular response to mating pheromone; KIN82 has a paralog, FPK1, that arose from the whole genome duplication.


ensembl_gene_id: YCR092C
symbol: MSH3
gene_biotype: protein_coding
description:
  Mismatch repair protein; forms dimers with Msh2p that mediate repair of insertion or deletion mutations and removal of nonhomologous DNA ends, contains a PCNA (Pol30p) binding motif required for genome stability; Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.


ensembl_gene_id: YCR093W
symbol: CDC39
gene_biotype: protein_coding
description:
  General negative regulator of transcription subunit 1; Subunit of the CCR4-NOT1 core complex; this complex has multiple roles in the regulation of mRNA levels including regulation of transcription and destabilization of mRNA by deadenylation; basal transcription factor that increases initiation and elongation; activates the ATPase activity of Dhh1p, resulting in processing body disassembly.


ensembl_gene_id: YCR094W
symbol: CDC50
gene_biotype: protein_coding
description:
  Cell division control protein 50; Endosomal protein that interacts with phospholipid flippase Drs2p; interaction with Cdc50p is essential for Drs2p catalytic activity; mutations affect cell polarity and polarized growth; similar to Lem3p; CDC50 has a paralog, YNR048W, that arose from the whole genome duplication.


ensembl_gene_id: YCR095C
symbol: OCA4
gene_biotype: protein_coding
description:
  Cytoplasmic protein required for replication of Brome mosaic virus; S. cerevisiae is a model system for studying replication of positive-strand RNA viruses in their natural hosts.


ensembl_gene_id: YCR096C
symbol: HMRA2
gene_biotype: protein_coding
description:
  Silenced copy of a2 at HMR; similarity to Alpha2p; required along with a1p for inhibiting expression of the HO endonuclease in a/alpha HO/HO diploid cells with an active mating-type interconversion system.


ensembl_gene_id: YCR097W
symbol: HMRA1
gene_biotype: protein_coding
description:
  Silenced copy of a1 at HMR; homeobox corepressor that interacts with Alpha2p to repress haploid-specific gene transcription in diploid cells.


ensembl_gene_id: YCR097W-A
symbol: YCR097W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YCR097W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by homology to a hemiascomycetous yeast protein.


ensembl_gene_id: YCR098C
symbol: GIT1
gene_biotype: protein_coding
description:
  Glycerophosphoinositol transporter 1; Plasma membrane permease; mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.


ensembl_gene_id: YCR101C
symbol: YCR101C
gene_biotype: protein_coding
description:
  Uncharacterized protein YCR101C; Putative protein of unknown function; localizes to the membrane fraction; YCR101C is not an essential gene.


ensembl_gene_id: YCR102C
symbol: YCR102C
gene_biotype: protein_coding
description:
  Uncharacterized protein YCR102C; Putative protein of unknown function; involved in copper metabolism; similar to C. carbonum toxD gene; member of the quinone oxidoreductase family; Belongs to the YCR102c/YLR460c/YNL134c family.


ensembl_gene_id: YCR102W-A
symbol: YCR102W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YCR102W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YCR104W
symbol: PAU3
gene_biotype: protein_coding
description:
  Seripauperin-3; Member of the seripauperin multigene family; encoded mainly in subtelomeric region; active during alcoholic fermentation; regulated by anaerobiosis; negatively regulated by oxygen; repressed by heme.


ensembl_gene_id: YCR105W
symbol: ADH7
gene_biotype: protein_coding
description:
  NADPH-dependent medium chain alcohol dehydrogenase; has broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance.


ensembl_gene_id: YCR106W
symbol: RDS1
gene_biotype: protein_coding
description:
  Regulator of drug sensitivity 1; Putative zinc cluster transcription factor; involved in conferring resistance to cycloheximide.


ensembl_gene_id: YCR107W
symbol: AAD3
gene_biotype: protein_coding
description:
  Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role; AAD3 has a paralog, AAD15, that arose from a segmental duplication; members of the AAD gene family comprise three pairs (AAD3 + AAD15, AAD6/AAD16 + AAD4, AAD10 + AAD14) whose two genes are more related to one another than to other members of the family; Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.


ensembl_gene_id: YCR108C
symbol: YCR108C
gene_biotype: protein_coding
description:
  Uncharacterized protein YCR108C; Putative protein of unknown function; identified by fungal homology and RT-PCR.


ensembl_gene_id: YDL002C
symbol: NHP10
gene_biotype: protein_coding
description:
  Non-histone protein 10; Non-essential INO80 chromatin remodeling complex subunit; preferentially binds DNA ends, protecting them from exonucleatic cleavage; deletion affects telomere maintenance via recombination; related to mammalian high mobility group proteins.


ensembl_gene_id: YDL003W
symbol: MCD1
gene_biotype: protein_coding
description:
  Sister chromatid cohesion protein 1; Essential alpha-kleisin subunit of the cohesin complex; required for sister chromatid cohesion in mitosis and meiosis; apoptosis induces cleavage and translocation of a C-terminal fragment to mitochondria; expression peaks in S phase.


ensembl_gene_id: YDL004W
symbol: ATP16
gene_biotype: protein_coding
description:
  Delta subunit of the central stalk of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; F1 translationally regulates ATP6 and ATP8 expression to achieve a balanced output of ATP synthase genes encoded in nucleus and mitochondria; phosphorylated.


ensembl_gene_id: YDL005C
symbol: MED2
gene_biotype: protein_coding
description:
  Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; relocalizes to the cytosol in response to hypoxia.


ensembl_gene_id: YDL006W
symbol: PTC1
gene_biotype: protein_coding
description:
  Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p, inactivating osmosensing MAPK cascade; involved in Fus3p activation during pheromone response; deletion affects precursor tRNA splicing, mitochondrial inheritance, and sporulation.


ensembl_gene_id: YDL007W
symbol: RPT2
gene_biotype: protein_coding
description:
  ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle; N-myristoylation of Rpt2p at Gly2 is involved in regulating the proper intracellular distribution of proteasome activity by controlling the nuclear localization of the 26S proteasome.


ensembl_gene_id: YDL008W
symbol: APC11
gene_biotype: protein_coding
description:
  Catalytic core subunit, Anaphase-Promoting Complex/Cyclosome (APC/C); which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; contains a RING-H2 domain that is required for activity.


ensembl_gene_id: YDL009C
symbol: YDL009C
gene_biotype: protein_coding
description:
  Uncharacterized protein YDL009C; Protein of unknown function; mRNA identified as translated by ribosome profiling data; SWAT-GFP and mCherry fusion proteins localize to the cytosol; partially overlaps the verified ORF YDL010W; YDL009C is not an essential gene.


ensembl_gene_id: YDL010W
symbol: GRX6
gene_biotype: protein_coding
description:
  Cis-golgi localized monothiol glutaredoxin, binds Fe-S cluster; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; GRX6 has a paralog, GRX7, that arose from the whole genome duplication.


ensembl_gene_id: YDL011C
symbol: YDL011C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YDL011C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the uncharacterized ORF YDL010W.


ensembl_gene_id: YDL012C
symbol: YDL012C
gene_biotype: protein_coding
description:
  Cysteine-rich and transmembrane domain-containing protein YDL012C; Tail-anchored plasma membrane protein with a conserved CYSTM module; possibly involved in response to stress; may contribute to non-homologous end-joining (NHEJ) based on ydl012c htz1 double null phenotype; YDL012C has a paralog, YBR016W, that arose from the whole genome duplication; Belongs to the CYSTM1 family.


ensembl_gene_id: YDL013W
symbol: SLX5
gene_biotype: protein_coding
description:
  Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex; role in Ub-mediated degradation of histone variant Cse4p preventing mislocalization to euchromatin; role in proteolysis of spindle positioning protein Kar9p, and DNA repair proteins Rad52p and Rad57p; forms SUMO-dependent nuclear foci, including DNA repair centers; contains a RING domain and two SIM motifs; associates with the centromere; required for maintenance of genome integrity like human ortholog RNF4.


ensembl_gene_id: YDL014W
symbol: NOP1
gene_biotype: protein_coding
description:
  rRNA 2'-O-methyltransferase fibrillarin; Histone glutamine methyltransferase, modifies H2A at Q105 in nucleolus; component of the small subunit processome complex, which is required for processing of pre-18S rRNA; ortholog of mammalian fibrillarin; inviability of the null mutant is functionally complemented by human FBL.


ensembl_gene_id: YDL015C
symbol: TSC13
gene_biotype: protein_coding
description:
  Very-long-chain enoyl-CoA reductase; Enoyl reductase; catalyzes last step in each cycle of very long chain fatty acid elongation; localizes to ER, highly enriched in a structure marking nuclear-vacuolar junctions; coimmunoprecipitates with elongases Elo2p and Elo3p; protein increases in abundance and relative distribution to ER foci increases upon DNA replication stress; human homolog TECR implicated in nonsyndromic mental retardation, can complement yeast mutant; Belongs to the steroid 5-alpha reductase family.


ensembl_gene_id: YDL016C
symbol: YDL016C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YDL016C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CDC7/YDL153C, the catalytic subunit of a complex that regulates DNA replication.


ensembl_gene_id: YDL017W
symbol: CDC7
gene_biotype: protein_coding
description:
  Cell division control protein 7; DDK (Dbf4-dependent kinase) catalytic subunit; required for origin firing and replication fork progression in mitotic S phase through phosphorylation of Mcm2-7p complexes and Cdc45p; kinase activity correlates with cyclical DBF4 expression; required for pre-meiotic DNA replication, meiotic DSB formation, recruitment of monopolin complex to kinetochores during meiosis I, regulation of meiosis-specific Ndt80p; mutation complemented by human CDC7 and DBF4 co-expression.


ensembl_gene_id: YDL018C
symbol: ERP3
gene_biotype: protein_coding
description:
  Protein with similarity to Emp24p and Erv25p; member of the p24 family involved in ER to Golgi transport.


ensembl_gene_id: YDL019C
symbol: OSH2
gene_biotype: protein_coding
description:
  Member of an oxysterol-binding protein family with seven members; in S. cerevisiae, family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability; contains FFAT motif; interacts with ER anchor Scs2p at patches at the plasma membrane and at the nuclear envelope; regulated by sterol binding; OSH2 has a paralog, SWH1, that arose from the whole genome duplication.


ensembl_gene_id: YDL020C
symbol: RPN4
gene_biotype: protein_coding
description:
  Protein RPN4; Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress.


ensembl_gene_id: YDL021W
symbol: GPM2
gene_biotype: protein_coding
description:
  Homolog of Gpm1p phosphoglycerate mutase; converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional; GPM2 has a paralog, GPM3, that arose from the whole genome duplication.


ensembl_gene_id: YDL022C-A
symbol: YDL022C-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YDL022C-A; Protein of unknown function; SWAT-GFP and mCherry fusion proteins localize to the cytosol; partially overlaps the verified gene DIA3; identified by fungal homology and RT-PCR; mRNA identified as translated by ribosome profiling data.


ensembl_gene_id: YDL022W
symbol: GPD1
gene_biotype: protein_coding
description:
  NAD-dependent glycerol-3-phosphate dehydrogenase; key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; protein abundance increases in response to DNA replication stress; constitutively inactivated via phosphorylation by the protein kinases Ypk1p and Ypk2p, dephosphorylation increases catalytic activity; forms a heterodimer with Pnc1p to facilitate its peroxisomal import.


ensembl_gene_id: YDL023C
symbol: YDL023C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YDL023C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in other Saccharomyces species; overlaps the verified gene GPD1; deletion confers sensitivity to GSAO; deletion in cyr1 mutant results in loss of stress resistance.


ensembl_gene_id: YDL024C
symbol: DIA3
gene_biotype: protein_coding
description:
  Probable acid phosphatase DIA3; Protein of unknown function; involved in invasive and pseudohyphal growth.


ensembl_gene_id: YDL025C
symbol: RTK1
gene_biotype: protein_coding
description:
  Probable serine/threonine-protein kinase RTK1; Putative protein kinase, potentially phosphorylated by Cdc28p; interacts with ribosome biogenesis factors, Cka2, Gus1 and Arc1; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YDL025W-A
symbol: YDL025W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YDL025W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the ORF YDL025C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching.


ensembl_gene_id: YDL026W
symbol: YDL026W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YDL026W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YDL027C
symbol: MRX9
gene_biotype: protein_coding
description:
  MIOREX complex component 9; Protein that associates with mitochondrial ribosome; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL027C is not an essential gene.


ensembl_gene_id: YDL028C
symbol: MPS1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase MPS1; Dual-specificity kinase; autophosphorylation required for function; required for spindle pole body (SPB) duplication and spindle checkpoint function; contributes to bi-orientation by promoting formation of force-generating kinetochore-microtubule attachments in meiosis I; substrates include SPB proteins Spc42p, Spc110p, and Spc98p, mitotic exit network protein Mob1p, kinetochore protein Cnn1p, and checkpoint protein Mad1p; substrate of APCC(Cdh1); similar to human Mps1p.


ensembl_gene_id: YDL029W
symbol: ARP2
gene_biotype: protein_coding
description:
  Actin-related protein 2; Essential component of the Arp2/3 complex; Arp2/3 is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity; required for efficient Golgi-to-ER trafficking in COPI mutants.


ensembl_gene_id: YDL030W
symbol: PRP9
gene_biotype: protein_coding
description:
  Pre-mRNA-splicing factor PRP9; Subunit of the SF3a splicing factor complex; required for spliceosome assembly; acts after the formation of the U1 snRNP-pre-mRNA complex; Belongs to the SF3A3 family.


ensembl_gene_id: YDL031W
symbol: DBP10
gene_biotype: protein_coding
description:
  Putative ATP-dependent RNA helicase of the DEAD-box protein family; constituent of 66S pre-ribosomal particles; essential protein involved in ribosome biogenesis; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.


ensembl_gene_id: YDL032W
symbol: YDL032W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YDL032w; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified gene SLM3/YDL033C; YDL032W is not an essential gene.


ensembl_gene_id: YDL033C
symbol: SLM3
gene_biotype: protein_coding
description:
  tRNA-specific 2-thiouridylase; responsible for 2-thiolation of the wobble base of mitochondrial tRNAs; human homolog TRMU is implicated in myoclonus epilepsy associated with ragged red fibers (MERRF), and can complement yeast null mutant.


ensembl_gene_id: YDL034W
symbol: YDL034W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YDL034W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps with verified gene GPR1/YDL035C; YDL034W is not an essential gene.


ensembl_gene_id: YDL035C
symbol: GPR1
gene_biotype: protein_coding
description:
  Plasma membrane G protein coupled receptor (GPCR); interacts with the heterotrimeric G protein alpha subunit, Gpa2p, and with Plc1p; sensor that integrates nutritional signals with the modulation of cell fate via PKA and cAMP synthesis.


ensembl_gene_id: YDL036C
symbol: PUS9
gene_biotype: protein_coding
description:
  Mitochondrial tRNA:pseudouridine synthase; catalyzes the formation of pseudouridine at position 32 in mitochondrial tRNAs; contains an N-terminal mitochondrial targeting sequence; PUS9 has a paralog, RIB2, that arose from the whole genome duplication.


ensembl_gene_id: YDL037C
symbol: BSC1
gene_biotype: protein_coding
description:
  Bypass of stop codon protein 1; Protein of unconfirmed function; similar to cell surface flocculin Flo11p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; in W303 strain one continuous open reading frame comprising of YDL037C, the intergenic region and YDL039C encodes the gene IMI1.


ensembl_gene_id: YDL039C
symbol: PRM7
gene_biotype: protein_coding
description:
  Pheromone-regulated protein; predicted to have one transmembrane segment; promoter contains Gcn4p binding elements; in W303 strain one continuous open reading frame comprising of YDL037C, the intergenic region and YDL039C encodes the IMI1.


ensembl_gene_id: YDL040C
symbol: NAT1
gene_biotype: protein_coding
description:
  Subunit of protein N-terminal acetyltransferase NatA; NatA comprised of Nat1p, Ard1p, and Nat5p; N-terminally acetylates many proteins to influence multiple processes such as cell cycle progression, heat-shock resistance, mating, sporulation, telomeric silencing and early stages of mitophagy; orthologous to human NAA15; expression of both human NAA10 and NAA15 functionally complements ard1 nat1 double mutant although single mutations are not complemented by their orthologs.


ensembl_gene_id: YDL041W
symbol: YDL041W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YDL041W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene SIR2/YDL042C.


ensembl_gene_id: YDL042C
symbol: SIR2
gene_biotype: protein_coding
description:
  Conserved NAD+ dependent histone deacetylase of the Sirtuin family; deacetylation targets are primarily nuclear proteins; required for telomere hypercluster formation in quiescent yeast cells; involved in regulation of lifespan; plays roles in silencing at HML, HMR, telomeres, and rDNA; negatively regulates initiation of DNA replication; functions as regulator of autophagy like mammalian homolog SIRT1, and also of mitophagy.


ensembl_gene_id: YDL043C
symbol: PRP11
gene_biotype: protein_coding
description:
  Pre-mRNA-splicing factor PRP11; Subunit of the SF3a splicing factor complex; required for spliceosome assembly.


ensembl_gene_id: YDL044C
symbol: MTF2
gene_biotype: protein_coding
description:
  Mitochondrial transcription factor 2; Mitochondrial protein that interacts with mitochondrial RNA polymerase; interacts with an N-terminal region of mitochondrial RNA polymerase (Rpo41p) and couples RNA processing and translation to transcription.


ensembl_gene_id: YDL045C
symbol: FAD1
gene_biotype: protein_coding
description:
  FAD synthase; Flavin adenine dinucleotide (FAD) synthetase; performs the second step in synthesis of FAD from riboflavin; mutation is functionally complemented by human FLAD1.


ensembl_gene_id: YDL045W-A
symbol: MRP10
gene_biotype: protein_coding
description:
  Mitochondrial ribosomal protein of the small subunit; contains twin cysteine-x9-cysteine motifs; oxidized by Mia40p during import into mitochondria.


ensembl_gene_id: YDL046W
symbol: NPC2
gene_biotype: protein_coding
description:
  Phosphatidylglycerol/phosphatidylinositol transfer protein; Sterol transport protein and functional homolog of human NPC2/He1; human NPC2 is a cholesterol-binding protein whose deficiency causes Niemann-Pick type C2 disease involving retention of cholesterol in lysosomes; yeast NPC2 can complement mutations in human NPC2; Belongs to the NPC2 family.


ensembl_gene_id: YDL047W
symbol: SIT4
gene_biotype: protein_coding
description:
  Serine/threonine-protein phosphatase PP1-1; Ceramide-activated, type 2A-related serine-threonine phosphatase; functions in G1/S transition of mitotic cycle; controls lifespan, mitochondrial function, cell cycle progression by regulating HXK2 phosphorylation; regulator of COPII coat dephosphorylation; required for ER to Golgi traffic; interacts with Hrr25p kinase; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization; similar to human PP6.


ensembl_gene_id: YDL048C
symbol: STP4
gene_biotype: protein_coding
description:
  Protein containing a Kruppel-type zinc-finger domain; similar to Stp1p, Stp2p; predicted transcription factor; relative distribution to the nucleus increases upon DNA replication stress; STP4 has a paralog, STP3, that arose from the whole genome duplication.


ensembl_gene_id: YDL049C
symbol: KNH1
gene_biotype: protein_coding
description:
  Protein with similarity to Kre9p; Kre9p is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance.


ensembl_gene_id: YDL050C
symbol: YDL050C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YDL050C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YDL051W
symbol: LHP1
gene_biotype: protein_coding
description:
  La protein homolog; RNA binding protein required for maturation of tRNA and U6 snRNA; acts as a molecular chaperone for RNAs transcribed by polymerase III; homologous to human La (SS-B) autoantigen.


ensembl_gene_id: YDL052C
symbol: SLC1
gene_biotype: protein_coding
description:
  1-acyl-sn-glycerol-3-phosphate acyltransferase; catalyzes the acylation of lysophosphatidic acid to form phosphatidic acid, a key intermediate in lipid metabolism; enzymatic activity detected in lipid particles and microsomes.


ensembl_gene_id: YDL053C
symbol: PBP4
gene_biotype: protein_coding
description:
  Pbp1p binding protein; interacts strongly with Pab1p-binding protein 1 (Pbp1p) in the yeast two-hybrid system; also interacts with Lsm12p in a copurification assay; relative distribution to the nucleus increases upon DNA replication stress.


ensembl_gene_id: YDL054C
symbol: MCH1
gene_biotype: protein_coding
description:
  Probable transporter MCH1; Protein with similarity to mammalian monocarboxylate permeases; monocarboxylate permeases are involved in transport of monocarboxylic acids across the plasma membrane but mutant is not deficient in monocarboxylate transport; Belongs to the major facilitator superfamily.


ensembl_gene_id: YDL055C
symbol: PSA1
gene_biotype: protein_coding
description:
  GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase); synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure.


ensembl_gene_id: YDL056W
symbol: MBP1
gene_biotype: protein_coding
description:
  Transcription factor; involved in regulation of cell cycle progression from G1 to S phase, forms a complex with Swi6p that binds to MluI cell cycle box regulatory element in promoters of DNA synthesis genes.


ensembl_gene_id: YDL058W
symbol: USO1
gene_biotype: protein_coding
description:
  Essential protein involved in vesicle-mediated ER to Golgi transport; binds membranes and functions during vesicle docking to the Golgi; required for assembly of the ER-to-Golgi SNARE complex.


ensembl_gene_id: YDL059C
symbol: RAD59
gene_biotype: protein_coding
description:
  Protein involved DNA double-strand break repair; repairs breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; forms nuclear foci upon DNA replication stress; required for loading of Rad52p to DSBs; regulates replication fork progression in DNA ligase I-deficient cells; paralog of Rad52p; Belongs to the RAD52 family.


ensembl_gene_id: YDL060W
symbol: TSR1
gene_biotype: protein_coding
description:
  Ribosome biogenesis protein TSR1; Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits with assembling 40S subunits in the cytoplasm; similar to Bms1p; relocalizes from nucleus to cytoplasm upon DNA replication stress; Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. TSR1 subfamily.


ensembl_gene_id: YDL061C
symbol: RPS29B
gene_biotype: protein_coding
description:
  Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S29 and bacterial S14; RPS29B has a paralog, RPS29A, that arose from the whole genome duplication.


ensembl_gene_id: YDL062W
symbol: YDL062W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YDL062W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YDL063C; YDL062W is not essential.


ensembl_gene_id: YDL063C
symbol: SYO1
gene_biotype: protein_coding
description:
  Synchronized import protein 1; Transport adaptor or symportin; facilitates synchronized nuclear coimport of the two 5S-rRNA binding proteins Rpl5p and Rpl11p; binds to nascent Rpl5p during translation; required for biogenesis of the large ribosomal subunit; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus.


ensembl_gene_id: YDL064W
symbol: UBC9
gene_biotype: protein_coding
description:
  SUMO-conjugating enzyme involved in the Smt3p conjugation pathway; nuclear protein required for S- and M-phase cyclin degradation and mitotic control; involved in proteolysis mediated by the anaphase-promoting complex cyclosome (APCC).


ensembl_gene_id: YDL065C
symbol: PEX19
gene_biotype: protein_coding
description:
  Chaperone and import receptor for newly-synthesized class I PMPs; binds peroxisomal membrane proteins (PMPs) in the cytoplasm and delivers them to the peroxisome for subsequent insertion into the peroxisomal membrane; interacts with Myo2p and contributes to peroxisome partitioning.


ensembl_gene_id: YDL066W
symbol: IDP1
gene_biotype: protein_coding
description:
  Mitochondrial NADP-specific isocitrate dehydrogenase; catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes.


ensembl_gene_id: YDL067C
symbol: COX9
gene_biotype: protein_coding
description:
  Subunit VIIa of cytochrome c oxidase (Complex IV); Complex IV is the terminal member of the mitochondrial inner membrane electron transport chain.


ensembl_gene_id: YDL068W
symbol: YDL068W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YDL068W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YDL069C
symbol: CBS1
gene_biotype: protein_coding
description:
  Mitochondrial translational activator of the COB mRNA; membrane protein that interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader.


ensembl_gene_id: YDL070W
symbol: BDF2
gene_biotype: protein_coding
description:
  Bromodomain-containing factor 2; Protein involved in transcription initiation; acts at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf1p; protein abundance increases in response to DNA replication stress; BDF2 has a paralog, BDF1, that arose from the whole genome duplication.


ensembl_gene_id: YDL071C
symbol: YDL071C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YDL071C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF BDF2/YDL070W.


ensembl_gene_id: YDL072C
symbol: YET3
gene_biotype: protein_coding
description:
  Endoplasmic reticulum transmembrane protein 3; Protein of unknown function; YET3 null mutant decreases the level of secreted invertase; homolog of human BAP31 protein; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YDL073W
symbol: AHK1
gene_biotype: protein_coding
description:
  UPF0592 protein YDL073W; Scaffold protein in the HKR1 sub-branch of the Hog1p-signaling pathway; physically interacts with the cytoplasmic domain of Hkr1p, and with Sho1p, Pbs2p, and Ste11p; prevents cross-talk signaling from Hkr1p of the osmotic stress MAPK cascade to the Kss1p MAPK cascade; non-essential gene.


ensembl_gene_id: YDL074C
symbol: BRE1
gene_biotype: protein_coding
description:
  E3 ubiquitin ligase; forms heterodimer with Rad6p to regulate K63 polyubiquitination in response to oxidative stress and to monoubiquinate histone H2B-K123, which is required for the subsequent methylation of histone H3-K4 and H3-K79; required for DSBR, transcription, silencing, and checkpoint control; interacts with RNA-binding protein Npl3p, linking histone ubiquitination to mRNA processing; Bre1p-dependent histone ubiquitination promotes pre-mRNA splicing.


ensembl_gene_id: YDL075W
symbol: RPL31A
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L31A; associates with karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality; homologous to mammalian ribosomal protein L31, no bacterial homolog; RPL31A has a paralog, RPL31B, that arose from the whole genome duplication.


ensembl_gene_id: YDL076C
symbol: RXT3
gene_biotype: protein_coding
description:
  Transcriptional regulatory protein RXT3; Component of the Rpd3L histone deacetylase complex; involved in histone deacetylation; protein abundance increases in response to DNA replication stress; Belongs to the RXT3 family.


ensembl_gene_id: YDL077C
symbol: VAM6
gene_biotype: protein_coding
description:
  Vacuolar morphogenesis protein 6; Guanine nucleotide exchange factor for the GTPase Gtr1p; subunit of the HOPS endocytic tethering complex; vacuole membrane protein; functions as a Rab GTPase effector, interacting with both GTP- and GDP-bound conformations of Ypt7p; facilitates tethering and promotes membrane fusion events at the late endosome and vacuole; required for both membrane and protein trafficking; component of vacuole-mitochondrion contacts (vCLAMPs) important for lipid transfer between organelles.


ensembl_gene_id: YDL078C
symbol: MDH3
gene_biotype: protein_coding
description:
  Peroxisomal malate dehydrogenase; catalyzes interconversion of malate and oxaloacetate; involved in the glyoxylate cycle.


ensembl_gene_id: YDL079C
symbol: MRK1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase MRK1; Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation; MRK1 has a paralog, RIM11, that arose from the whole genome duplication.


ensembl_gene_id: YDL080C
symbol: THI3
gene_biotype: protein_coding
description:
  Thiamine metabolism regulatory protein THI3; Regulatory protein that binds Pdc2p and Thi2p transcription factors; activates thiamine biosynthesis transcription factors Pdc2p and Thi2p by binding to them, but releases and de-activates them upon binding to thiamine pyrophosphate (TPP), the end product of the pathway; has similarity to decarboxylases but enzymatic activity is not detected.


ensembl_gene_id: YDL081C
symbol: RPP1A
gene_biotype: protein_coding
description:
  60S acidic ribosomal protein P1-alpha; Ribosomal stalk protein P1 alpha; involved in the interaction between translational elongation factors and the ribosome; free (non-ribosomal) P1 stimulates the phosphorylation of the eIF2 alpha subunit (Sui2p) by Gcn2p; accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component.


ensembl_gene_id: YDL082W
symbol: RPL13A
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L13A; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13A has a paralog, RPL13B, that arose from the whole genome duplication.


ensembl_gene_id: YDL083C
symbol: RPS16B
gene_biotype: protein_coding
description:
  Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S16 and bacterial S9; RPS16B has a paralog, RPS16A, that arose from the whole genome duplication.


ensembl_gene_id: YDL084W
symbol: SUB2
gene_biotype: protein_coding
description:
  ATP-dependent RNA helicase SUB2; Component of the TREX complex required for nuclear mRNA export; member of the DEAD-box RNA helicase superfamily and is involved in early and late steps of spliceosome assembly; homolog of the human splicing factor hUAP56; relocalizes from nucleus to cytoplasm upon DNA replication stress.


ensembl_gene_id: YDL085C-A
symbol: YDL085C-A
gene_biotype: protein_coding
description:
  SERF-like protein YDL085C-A; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; Belongs to the SERF family.


ensembl_gene_id: YDL085W
symbol: NDE2
gene_biotype: protein_coding
description:
  External NADH-ubiquinone oxidoreductase 2, mitochondrial; Mitochondrial external NADH dehydrogenase; catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain; NDE2 has a paralog, NDE1, that arose from the whole genome duplication.


ensembl_gene_id: YDL086C-A
symbol: YDL086C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YDL086C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps uncharacterized ORF YDL086W; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching.


ensembl_gene_id: YDL086W
symbol: YDL086W
gene_biotype: protein_coding
description:
  Putative carboxymethylenebutenolidase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene; Belongs to the dienelactone hydrolase family.


ensembl_gene_id: YDL087C
symbol: LUC7
gene_biotype: protein_coding
description:
  Essential protein associated with the U1 snRNP complex; splicing factor involved in recognition of 5' splice site; contains two zinc finger motifs; N-terminal zinc finger binds pre-mRNA; relocalizes to the cytosol in response to hypoxia; Belongs to the Luc7 family.


ensembl_gene_id: YDL088C
symbol: ASM4
gene_biotype: protein_coding
description:
  FG-nucleoporin component of central core of nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport; induces membrane tubulation, which may contribute to nuclear pore assembly; ASM4 has a paralog, NUP53, that arose from the whole genome duplication.


ensembl_gene_id: YDL089W
symbol: NUR1
gene_biotype: protein_coding
description:
  Nuclear rim protein 1; Protein involved in regulation of mitotic exit; dephosphorylation target of Cdc14p in anaphase, which promotes timely rDNA segregation and allows mitotic progression; interacts with Csm1p, Lrs4p; required for rDNA repeat stability; null mutant causes increase in unequal sister-chromatid exchange; GFP-fusion protein localizes to the nuclear periphery, possible Cdc28p substrate; Belongs to the NUR1 family.


ensembl_gene_id: YDL090C
symbol: RAM1
gene_biotype: protein_coding
description:
  Beta subunit of the CAAX farnesyltransferase (FTase); this complex prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit.


ensembl_gene_id: YDL091C
symbol: UBX3
gene_biotype: protein_coding
description:
  UBX domain-containing protein 3; Clathrin-coated vesicle component, regulator of endocytosis; copurifies with the DSC ubiquitin ligase complex; UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p; required for efficient clathrin-mediated endocytosis; ortholog of fission yeast Ucp10.


ensembl_gene_id: YDL092W
symbol: SRP14
gene_biotype: protein_coding
description:
  Signal recognition particle (SRP) subunit; interacts with the RNA component of SRP to form the Alu domain, which is the region of SRP responsible for arrest of nascent chain elongation during membrane targeting; homolog of mammalian SRP14.


ensembl_gene_id: YDL093W
symbol: PMT5
gene_biotype: protein_coding
description:
  Dolichyl-phosphate-mannose--protein mannosyltransferase 5; Protein O-mannosyltransferase; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt3p, can instead interact with Pmt2p in some conditions; target for new antifungals.


ensembl_gene_id: YDL094C
symbol: YDL094C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YDL094C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verfied gene PMT5/YDL093W; YDL094C is not essential.


ensembl_gene_id: YDL095W
symbol: PMT1
gene_biotype: protein_coding
description:
  Dolichyl-phosphate-mannose--protein mannosyltransferase 1; Protein O-mannosyltransferase of the ER membrane; transfers mannose from dolichyl phosphate-D-mannose to protein serine and threonine residues; 1 of 7 related proteins involved in O-glycosylation which is essential for cell wall rigidity; involved in ER quality control; amino terminus faces cytoplasm, carboxyl terminus faces ER lumen; Belongs to the glycosyltransferase 39 family.


ensembl_gene_id: YDL096C
symbol: OPI6
gene_biotype: protein_coding
description:
  Putative uncharacterized protein OPI6; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified gene PMT1/YDL095W; YDL096C is not essential.


ensembl_gene_id: YDL097C
symbol: RPN6
gene_biotype: protein_coding
description:
  Essential, non-ATPase regulatory subunit of the 26S proteasome lid; required for the assembly and activity of the 26S proteasome; the human homolog (S9 protein) partially rescues Rpn6p depletion; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YDL098C
symbol: SNU23
gene_biotype: protein_coding
description:
  23 kDa U4/U6.U5 small nuclear ribonucleoprotein component; Component of the U4/U6.U5 snRNP complex; involved in mRNA splicing via spliceosome.


ensembl_gene_id: YDL099W
symbol: BUG1
gene_biotype: protein_coding
description:
  Binder of USO1 and GRH1 protein 1; Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes.


ensembl_gene_id: YDL100C
symbol: GET3
gene_biotype: protein_coding
description:
  ATPase GET3; Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; functions as a chaperone under ATP-depleted oxidative stress conditions; subunit of GET complex, involved in ATP dependent Golgi to ER trafficking and insertion of tail-anchored (TA) proteins into ER membrane under non-stress conditions; binds as dimer to transmembrane domain (TMD) cargo, shielding TMDs from aqueous solvent; protein abundance increases under DNA replication stress.


ensembl_gene_id: YDL101C
symbol: DUN1
gene_biotype: protein_coding
description:
  DNA damage response protein kinase DUN1; Cell-cycle checkpoint S/T protein kinase; required for transient G2/M arrest after DNA damage, damage-induced transcription, and nuclear-to-cytoplasmic redistribution of Rnr2p-Rnr4p after genotoxic stress and iron deprivation; phosphorylates repair protein Rad55p, transcriptional repressor Sml1p, superoxide dismutase, and ribonucleotide reductase inhibitors Crt1p and Dif1p; functions in the Mec1p pathway to regulate dNTP pools and telomere length; postreplicative repair role; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase [...]


ensembl_gene_id: YDL102W
symbol: POL3
gene_biotype: protein_coding
description:
  Catalytic subunit of DNA polymerase delta; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication during nucleotide excision repair (NER).


ensembl_gene_id: YDL103C
symbol: QRI1
gene_biotype: protein_coding
description:
  UDP-N-acetylglucosamine pyrophosphorylase; catalyzes the formation of UDP-N-acetylglucosamine (UDP-GlcNAc), which is important in cell wall biosynthesis, protein N-glycosylation, and GPI anchor biosynthesis; protein abundance increases in response to DNA replication stress; Belongs to the UDPGP type 1 family.


ensembl_gene_id: YDL104C
symbol: QRI7
gene_biotype: protein_coding
description:
  tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial; Protein involved in threonylcarbamoyl adenosine biosynthesis; Sua5p and Qri7p are necessary and sufficient for RNA t6A modification in vitro; highly conserved mitochondrial protein; essential for t6A modification of mitochondrial tRNAs that decode ANN codons; similar to Kae1p and E. coli YgjD, both of which are also required for tRNA t6A modification; when directed to the cytoplasm, complements the essential function of Kae1p in the KEOPS complex.


ensembl_gene_id: YDL105W
symbol: NSE4
gene_biotype: protein_coding
description:
  Non-structural maintenance of chromosome element 4; Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; Belongs to the NSE4 family.


ensembl_gene_id: YDL106C
symbol: PHO2
gene_biotype: protein_coding
description:
  Regulatory protein PHO2; Homeobox transcription factor; regulatory targets include genes involved in phosphate metabolism; binds cooperatively with Pho4p to the PHO5 promoter; phosphorylation of Pho2p facilitates interaction with Pho4p; relocalizes to the cytosol in response to hypoxia.


ensembl_gene_id: YDL107W
symbol: MSS2
gene_biotype: protein_coding
description:
  Protein MSS2, mitochondrial; Peripherally bound inner membrane protein of the mitochondrial matrix; involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p.


ensembl_gene_id: YDL108W
symbol: KIN28
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase KIN28; Serine/threonine protein kinase, subunit of transcription factor TFIIH; involved in transcription initiation at RNA polymerase II promoters; phosphorylates Ser5 residue of the PolII C-terminal domain (CTD) at gene promoters; relocalizes to the cytosol in response to hypoxia.


ensembl_gene_id: YDL109C
symbol: YDL109C
gene_biotype: protein_coding
description:
  Putative lipase; involved in lipid metabolism; not an essential gene; YDL109C has a paralog, ROG1, that arose from the whole genome duplication.


ensembl_gene_id: YDL110C
symbol: TMA17
gene_biotype: protein_coding
description:
  Translation machinery-associated protein 17; ATPase dedicated chaperone that adapts proteasome assembly to stress; Tma17p is induced upon stress; interacts with Rpt6p to assist its pairing to Rpt3p and early steps in proteasome biogenesis; associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion.


ensembl_gene_id: YDL111C
symbol: RRP42
gene_biotype: protein_coding
description:
  Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp42p (EXOSC7).


ensembl_gene_id: YDL112W
symbol: TRM3
gene_biotype: protein_coding
description:
  tRNA (guanosine(18)-2'-O)-methyltransferase; 2'-O-ribose methyltransferase; catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.


ensembl_gene_id: YDL113C
symbol: ATG20
gene_biotype: protein_coding
description:
  Autophagy-related protein 20; Sorting nexin family member; required for the cytoplasm-to-vacuole targeting (Cvt) pathway and for endosomal sorting; has a Phox homology domain that binds phosphatidylinositol-3-phosphate; interacts with Snx4p; potential Cdc28p substrate.


ensembl_gene_id: YDL114W
symbol: YDL114W
gene_biotype: protein_coding
description:
  Uncharacterized oxidoreductase YDL114W; Putative short-chain dehydrogenase/reductase; YDL114W is not an essential gene; Belongs to the short-chain dehydrogenases/reductases (SDR) family.


ensembl_gene_id: YDL114W-A
symbol: YDL114W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YDL114W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified based on homology to hemiascomycetous yeasts.


ensembl_gene_id: YDL115C
symbol: IWR1
gene_biotype: protein_coding
description:
  RNA polymerase II nuclear localization protein IWR1; RNA polymerase II transport factor, conserved from yeast to humans; also has a role in transporting RNA polymerase III into the nucleus; interacts with most of the RNAP II subunits; nucleo-cytoplasmic shuttling protein; deletion causes hypersensitivity to K1 killer toxin; protein increases in abundance and relocalizes from nucleus to cytoplasm upon DNA replication stress.


ensembl_gene_id: YDL116W
symbol: NUP84
gene_biotype: protein_coding
description:
  Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP107.


ensembl_gene_id: YDL117W
symbol: CYK3
gene_biotype: protein_coding
description:
  SH3-domain protein located in the bud neck and cytokinetic actin ring; relocalizes from bud neck to nucleus upon DNA replication stress; activates the chitin synthase activity of Chs2p during cytokinesis; suppressor of growth and cytokinesis defects of chs2 phospho-mutants.


ensembl_gene_id: YDL118W
symbol: YDL118W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YDL118W; Dubious open reading frame, unlikely to encode a protein; overlaps almost completely with YDL119C; mutations that would affect both YDL118W and YDL119C confer defective telomere maintenance and are synthetically sick or lethal with alpha-synuclein.


ensembl_gene_id: YDL119C
symbol: HEM25
gene_biotype: protein_coding
description:
  Mitochondrial glycine transporter; required for the transport of glycine into mitochondria for initiation of heme biosynthesis, with YMC1 acting as a secondary transporter; homolog of human SLC25A38, a mitochondrial glycine transporter associated with nonsyndromic autosomal recessive congenital sideroblastic anemia; human SLC25A38 can complement the heme deficiency associated with the null mutant; GFP-fusion protein is induced in response to the DNA-damaging agent MMS.


ensembl_gene_id: YDL120W
symbol: YFH1
gene_biotype: protein_coding
description:
  Frataxin homolog intermediate form; Mitochondrial matrix iron chaperone; oxidizes and stores iron; interacts with Isu1p to promote Fe-S cluster assembly; mutation results in multiple Fe/S-dependent enzyme deficiencies; human frataxin homolog FXN is mutated in Friedrich's ataxia; human FTL gene can complement yeast yfh1 null mutant.


ensembl_gene_id: YDL121C
symbol: YDL121C
gene_biotype: protein_coding
description:
  ER export of PMA1 protein 1; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDL121C is not an essential protein.


ensembl_gene_id: YDL122W
symbol: UBP1
gene_biotype: protein_coding
description:
  Ubiquitin carboxyl-terminal hydrolase 1; Ubiquitin-specific protease; removes ubiquitin from ubiquitinated proteins; cleaves at the C terminus of ubiquitin fusions irrespective of their size; capable of cleaving polyubiquitin chains.


ensembl_gene_id: YDL123W
symbol: SNA4
gene_biotype: protein_coding
description:
  Protein of unknown function; localized to the vacuolar outer membrane; predicted to be palmitoylated.


ensembl_gene_id: YDL124W
symbol: YDL124W
gene_biotype: protein_coding
description:
  NADPH-dependent alpha-keto amide reductase; reduces aromatic alpha-keto amides, aliphatic alpha-keto esters, and aromatic alpha-keto esters; member of the aldo-keto reductase (AKR) family; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YDL125C
symbol: HNT1
gene_biotype: protein_coding
description:
  Hit family protein 1; Adenosine 5'-monophosphoramidase; interacts physically and genetically with Kin28p, a CDK and TFIIK subunit, and genetically with CAK1; member of histidine triad (HIT) superfamily of nucleotide-binding proteins; protein abundance increases in response to DNA replication stress; human homolog HINT1 can complement yeast hnt1 mutant.


ensembl_gene_id: YDL126C
symbol: CDC48
gene_biotype: protein_coding
description:
  Cell division control protein 48; AAA ATPase; subunit of polyUb-selective segregase complex involved in ERAD, INM-associated degradation (INMAD), mitotic spindle disassembly, macroautophagy, PMN, ribosome-associated degradation, ribophagy, homotypic ER membrane fusion, SCF complex disassembly, cell wall integrity during heat stress, and telomerase regulation; mobilizes membrane-anchored transcription factors by regulated Ub/proteasome-dependent processing (RUP); human ortholog VCP complements a cdc48 mutant.


ensembl_gene_id: YDL127W
symbol: PCL2
gene_biotype: protein_coding
description:
  PHO85 cyclin-2; Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; localizes to sites of polarized cell growth; PCL2 has a paralog, PCL9, that arose from the whole genome duplication.


ensembl_gene_id: YDL128W
symbol: VCX1
gene_biotype: protein_coding
description:
  Vacuolar calcium ion transporter; Vacuolar membrane antiporter with Ca2+/H+ and K+/H+ exchange activity; involved in control of cytosolic Ca2+ and K+ concentrations; has similarity to sodium/calcium exchangers, including the bovine Na+/Ca2+,K+ antiporter.


ensembl_gene_id: YDL129W
symbol: YDL129W
gene_biotype: protein_coding
description:
  Uncharacterized protein YDL129W; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; YDL129W is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress.


ensembl_gene_id: YDL130W
symbol: RPP1B
gene_biotype: protein_coding
description:
  60S acidic ribosomal protein P1-beta; Ribosomal protein P1 beta; component of the ribosomal stalk, which is involved in interaction of translational elongation factors with ribosome; free (non-ribosomal) P1 stimulates the phosphorylation of the eIF2 alpha subunit (Sui2p) by Gcn2p; accumulation is regulated by phosphorylation and interaction with the P2 stalk component.


ensembl_gene_id: YDL130W-A
symbol: STF1
gene_biotype: protein_coding
description:
  ATPase-stabilizing factor 9 kDa, mitochondrial; Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p act as stabilizing factors that enhance inhibitory action of the Inh1p protein; protein abundance increases in response to DNA replication stress; STF1 has a paralog, INH1, that arose from the whole genome duplication.


ensembl_gene_id: YDL131W
symbol: LYS21
gene_biotype: protein_coding
description:
  Homocitrate synthase, mitochondrial; Homocitrate synthase isozyme; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS21 has a paralog, LYS20, that arose from the whole genome duplication; Belongs to the alpha-IPM synthase/homocitrate synthase family. Homocitrate synthase LYS20/LYS21 subfamily.


ensembl_gene_id: YDL132W
symbol: CDC53
gene_biotype: protein_coding
description:
  Cell division control protein 53; Cullin; structural protein of SCF complexes (which also contain Skp1p, Cdc34p, Hrt1p and an F-box protein) involved in ubiquitination; SCF promotes the G1-S transition by targeting G1 cyclins and the Cln-CDK inhibitor Sic1p for degradation; human homolog CUL1 can complement yeast cdc53 null mutant.


ensembl_gene_id: YDL133C-A
symbol: RPL41B
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L41B; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41B has a paralog, RPL41A, that arose from the whole genome duplication.


ensembl_gene_id: YDL133W
symbol: SRF1
gene_biotype: protein_coding
description:
  Regulator of phospholipase D (Spo14p); interacts with Spo14p and regulates its catalytic activity; capable of buffering the toxicity of C16:0 platelet activating factor, a lipid that accumulates intraneuronally in Alzheimer's patients.


ensembl_gene_id: YDL134C
symbol: PPH21
gene_biotype: protein_coding
description:
  Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph22p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; forms nuclear foci upon DNA replication stress; PPH21 has a paralog, PPH22, that arose from the whole genome duplication; Belongs to the PPP phosphatase family. PP-2A subfamily.


ensembl_gene_id: YDL135C
symbol: RDI1
gene_biotype: protein_coding
description:
  Rho GDP dissociation inhibitor; involved in the localization and regulation of Cdc42p and Rho1p; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YDL136W
symbol: RPL35B
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L35B; homologous to mammalian ribosomal protein L35 and bacterial L29; RPL35B has a paralog, RPL35A, that arose from the whole genome duplication.


ensembl_gene_id: YDL137W
symbol: ARF2
gene_biotype: protein_coding
description:
  ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi; ARF2 has a paralog, ARF1, that arose from the whole genome duplication; arf1 arf2 double null mutation is complemented by human ARF1, ARF4, ARF5, or ARF6.


ensembl_gene_id: YDL138W
symbol: RGT2
gene_biotype: protein_coding
description:
  Plasma membrane high glucose sensor that regulates glucose transport; low affinity sesnor that contains 12 predicted transmembrane segments and a long C-terminal tail required for hexose transporter induction; phosphorylation of the tail by Yck1p/Yck2p facilitates binding to the HXT co-repressors, Mth1p and Std1p; RGT2 has a paralog, SNF3, that arose from the whole genome duplication; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.


ensembl_gene_id: YDL139C
symbol: SCM3
gene_biotype: protein_coding
description:
  Protein SCM3; Nonhistone component of centromeric chromatin; binds to histone H3 variant, Cse4p, and recruits it to centromeres; involved in the assembly and maintenance of Cse4-H4 at centromeres; required for kinetochore assembly and G2/M progression; may protect Cse4p from ubiquitination; homolog of mammalian HJURP.


ensembl_gene_id: YDL140C
symbol: RPO21
gene_biotype: protein_coding
description:
  RNA polymerase II largest subunit B220; part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime.


ensembl_gene_id: YDL141W
symbol: BPL1
gene_biotype: protein_coding
description:
  Biotin--[propionyl-CoA-carboxylase [ATP-hydrolyzing]] ligase; Biotin:apoprotein ligase; covalently modifies proteins with the addition of biotin, required for acetyl-CoA carboxylase (Acc1p) holoenzyme formation; comparative analysis suggests that a mitochondrially targeted form may result from translation starting at a non-canonical codon upstream of the annotated start codon; human homolog HLCS can complement yeast BPL1 mutant.


ensembl_gene_id: YDL142C
symbol: CRD1
gene_biotype: protein_coding
description:
  Cardiolipin synthase; produces cardiolipin, which is a phospholipid of the mitochondrial inner membrane that is required for normal mitochondrial membrane potential and function and for correct integration of membrane-multispanning proteins into the mitochondrial outer membrane; required to maintain tubular mitochondrial morphology and functions in mitochondrial fusion; also required for normal vacuolar ion homeostasis; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.


ensembl_gene_id: YDL143W
symbol: CCT4
gene_biotype: protein_coding
description:
  T-complex protein 1 subunit delta; Subunit of the cytosolic chaperonin Cct ring complex; related to Tcp1p, required for the assembly of actin and tubulins in vivo.


ensembl_gene_id: YDL144C
symbol: YDL144C
gene_biotype: protein_coding
description:
  Uncharacterized protein YDL144C; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YDL144C is not an essential gene; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YDL145C
symbol: COP1
gene_biotype: protein_coding
description:
  Alpha subunit of COPI vesicle coatomer complex; complex surrounds transport vesicles in the early secretory pathway.


ensembl_gene_id: YDL146W
symbol: LDB17
gene_biotype: protein_coding
description:
  Protein involved in the regulation of endocytosis; transiently recruited to actin cortical patches in a SLA1-dependent manner after late coat component assembly; GFP-fusion protein localizes to the periphery, cytoplasm, bud, and bud neck; Belongs to the LDB17 family.


ensembl_gene_id: YDL147W
symbol: RPN5
gene_biotype: protein_coding
description:
  Subunit of the CSN and 26S proteasome lid complexes; similar to mammalian p55 subunit and to another S. cerevisiae regulatory subunit, Rpn7p; Rpn5p is an essential protein; the COP9 signalosome is also known as the CSN.


ensembl_gene_id: YDL148C
symbol: NOP14
gene_biotype: protein_coding
description:
  Nucleolar protein; forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA; Belongs to the NOP14 family.


ensembl_gene_id: YDL149W
symbol: ATG9
gene_biotype: protein_coding
description:
  Autophagy-related protein 9; Transmembrane protein involved in forming Cvt and autophagic vesicles; cycles between the phagophore assembly site (PAS) and other cytosolic punctate structures, not found in autophagosomes; may be involved in membrane delivery to the PAS; Belongs to the ATG9 family.


ensembl_gene_id: YDL150W
symbol: RPC53
gene_biotype: protein_coding
description:
  RNA polymerase III subunit C53; Belongs to the eukaryotic RPC4/POLR3D RNA polymerase subunit family.


ensembl_gene_id: YDL151C
symbol: BUD30
gene_biotype: protein_coding
description:
  Putative uncharacterized protein BUD30; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; 96% of ORF overlaps the verified gene RPC53; diploid mutant displays a weak budding pattern phenotype in a systematic assay.


ensembl_gene_id: YDL152W
symbol: YDL152W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YDL152W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SAS10/YDL153C, a component of the small ribosomal subunit processosome.


ensembl_gene_id: YDL153C
symbol: SAS10
gene_biotype: protein_coding
description:
  Something about silencing protein 10; Subunit of U3-containing Small Subunit (SSU) processome complex; involved in production of 18S rRNA and assembly of small ribosomal subunit; disrupts silencing when overproduced; mutant has increased aneuploidy tolerance; essential gene.


ensembl_gene_id: YDL154W
symbol: MSH5
gene_biotype: protein_coding
description:
  Protein of the MutS family; forms a dimer with Msh4p that facilitates crossovers between homologs during meiosis; msh5-Y823H mutation confers tolerance to DNA alkylating agents; homologs present in C. elegans and humans.


ensembl_gene_id: YDL155W
symbol: CLB3
gene_biotype: protein_coding
description:
  G2/mitotic-specific cyclin-3; B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation; relative distribution to the nucleus increases upon DNA replication stress; CLB3 has a paralog, CLB4, that arose from the whole genome duplication.


ensembl_gene_id: YDL156W
symbol: CMR1
gene_biotype: protein_coding
description:
  DNA damage-binding protein CMR1; Nuclear protein with a role in protein quality control; localizes to the intranuclear quality control compartment (INQ) in response to proteasome inhibition or DNA replication stress; INQ likely sequesters proteins involved in DNA metabolism for degradation or re-folding; DNA-binding protein with preference for UV-damaged DNA; contains three WD domains (WD-40 repeat); human ortholog WDR76 also exhibits perinuclear localization under similar stress conditions.


ensembl_gene_id: YDL157C
symbol: YDL157C
gene_biotype: protein_coding
description:
  Uncharacterized protein YDL157C, mitochondrial; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; To S.pombe tam6.


ensembl_gene_id: YDL158C
symbol: YDL158C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YDL158C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YDL159C-B
symbol: YDL159C-B
gene_biotype: protein_coding
description:
  Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching.


ensembl_gene_id: YDL159W
symbol: STE7
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase STE7; Signal transducing MAP kinase kinase; involved in pheromone response where it phosphorylates Fus3p; involved in the pseudohyphal/invasive growth pathway where it phosphorylates of Kss1p; phosphorylated by Ste11p; degraded by ubiquitin pathway.


ensembl_gene_id: YDL159W-A
symbol: YDL159W-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YDL159W-A; Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species.


ensembl_gene_id: YDL160C
symbol: DHH1
gene_biotype: protein_coding
description:
  Cytoplasmic DEAD-box helicase, stimulates mRNA decapping; coordinates distinct steps in mRNA function and decay, interacting with both decapping and deadenylase complexes; role in translational repression, mRNA decay, and possibly mRNA export; interacts and cooperates with Ngr1p to promote specific mRNA decay; ATP- and RNA-bound form promotes processing body (PB) assembly, while ATPase stimulation by Not1p promotes PB disassembly; forms cytoplasmic foci on replication stress; Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.


ensembl_gene_id: YDL160C-A
symbol: MHF2
gene_biotype: protein_coding
description:
  Inner kinetochore subunit MHF2; Component of the heterotetrameric MHF histone-fold complex; in humans the MHF complex interacts with both DNA and Mph1p ortholog FANCM to stabilize and remodel blocked replication forks and repair damaged DNA; mhf2 srs2 double mutants are MMS hypersensitive; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-X, also known as MHF2.


ensembl_gene_id: YDL161W
symbol: ENT1
gene_biotype: protein_coding
description:
  Epsin-1; Epsin-like protein involved in endocytosis and actin patch assembly; functionally redundant with Ent2p; binds clathrin via a clathrin-binding domain motif at C-terminus; relocalizes from bud neck to cytoplasm upon DNA replication stress; ENT1 has a paralog, ENT2, that arose from the whole genome duplication.


ensembl_gene_id: YDL162C
symbol: YDL162C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YDL162C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps ENT1/YDL161W, a verified gene involved in endocytosis and actin cortical patch assembly.


ensembl_gene_id: YDL163W
symbol: YDL163W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YDL163W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CDC9/YDL164C encoding DNA ligase.


ensembl_gene_id: YDL164C
symbol: CDC9
gene_biotype: protein_coding
description:
  DNA ligase I found in nucleus and mitochondria; essential enzyme that joins Okazaki fragments during DNA replication; also acts in ribonucleotide excision repair, base excision repair, and recombination; DNA ligase I mutants trigger ubiquitination of PCNA at K107, facilitating Rad59p-mediated bypass of unligated Okazaki fragments; human homolog LIG1 can complement yeast cdc9 temperature-sensitive mutant at restrictive temperature.


ensembl_gene_id: YDL165W
symbol: CDC36
gene_biotype: protein_coding
description:
  General negative regulator of transcription subunit 2; Component of the CCR4-NOT core complex, involved in mRNA decapping; this complex has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs through deadenylation; basal transcription factor.


ensembl_gene_id: YDL166C
symbol: FAP7
gene_biotype: protein_coding
description:
  Adenylate kinase isoenzyme 6 homolog FAP7; Essential NTPase required for small ribosome subunit synthesis; mediates processing of the 20S pre-rRNA at site D in the cytoplasm but associates only transiently with 43S preribosomes via Rps14p; complex with Rps14 is conserved between humans, yeast, and arches; may be the endonuclease for site D; depletion leads to accumulation of pre-40S ribosomes in 80S-like ribosomes; human TAF9 functionally complements the lethality of the null mutation.


ensembl_gene_id: YDL167C
symbol: NRP1
gene_biotype: protein_coding
description:
  Putative RNA binding protein of unknown function; localizes to stress granules induced by glucose deprivation; predicted to be involved in ribosome biogenesis.


ensembl_gene_id: YDL168W
symbol: SFA1
gene_biotype: protein_coding
description:
  Bifunctional alcohol dehydrogenase and formaldehyde dehydrogenase; formaldehyde dehydrogenase activity is glutathione-dependent; functions in formaldehyde detoxification and formation of long chain and complex alcohols, regulated by Hog1p-Sko1p; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YDL169C
symbol: UGX2
gene_biotype: protein_coding
description:
  Protein of unknown function; transcript accumulates in response to any combination of stress conditions.


ensembl_gene_id: YDL170W
symbol: UGA3
gene_biotype: protein_coding
description:
  Transcriptional activator for GABA-dependent induction of GABA genes; binds to DNA elements found in the promoters of target genes and increases their expression in the presence of GABA (gamma-aminobutyrate); zinc finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type; localized to the nucleus; examples of GABA genes include UGA1, UGA2, and UGA4.


ensembl_gene_id: YDL171C
symbol: GLT1
gene_biotype: protein_coding
description:
  NAD(+)-dependent glutamate synthase (GOGAT); synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source; assembles into filaments as cells approach stationary phase and under cytosolic acidification and starvation conditions.


ensembl_gene_id: YDL172C
symbol: YDL172C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YDL172C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YDL173W
symbol: PAR32
gene_biotype: protein_coding
description:
  Protein of unknown function; hyperphosphorylated upon rapamycin treatment in a Tap42p-dependent manner; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; PAR32 is not an essential gene.


ensembl_gene_id: YDL174C
symbol: DLD1
gene_biotype: protein_coding
description:
  Major mitochondrial D-lactate dehydrogenase; oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane.


ensembl_gene_id: YDL175C
symbol: AIR2
gene_biotype: protein_coding
description:
  Protein AIR2; RNA-binding subunit of the TRAMP nuclear RNA surveillance complex; involved in nuclear RNA processing and degradation; involved in TRAMP complex assembly as a bridge between Mtr4p and Trf4p; stimulates the poly(A) polymerase activity of Pap2p in vitro; has 5 zinc knuckle motifs; AIR2 has a paralog, AIR1, that arose from the whole genome duplication; Air2p and Air1p have nonredundant roles in regulation of substrate specificity of the exosome.


ensembl_gene_id: YDL176W
symbol: YDL176W
gene_biotype: protein_coding
description:
  Uncharacterized protein YDL176W; Protein of unknown function; predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene.


ensembl_gene_id: YDL177C
symbol: YDL177C
gene_biotype: protein_coding
description:
  IMPACT family member YDL177C; Putative protein of unknown function; similar to the mouse IMPACT gene; YDL177C is not an essential gene.


ensembl_gene_id: YDL178W
symbol: DLD2
gene_biotype: protein_coding
description:
  D-2-hydroxyglutarate--pyruvate transhydrogenase DLD2; D-2-hydroxyglutarate dehydrogenase, and minor D-lactate dehydrogenase; mitochondrial matrix protein that oxidizes D-2-hydroxyglutarate (D-2HG), an oncometabolite, to alpha-ketoglutarate with a minor role in lactate catabolism; located in the mitochondrial matrix; Belongs to the FAD-binding oxidoreductase/transferase type 4 family.


ensembl_gene_id: YDL179W
symbol: PCL9
gene_biotype: protein_coding
description:
  PHO85 cyclin-9; Cyclin; forms a functional kinase complex with Pho85p cyclin-dependent kinase (Cdk), expressed in late M/early G1 phase, activated by Swi5p; PCL9 has a paralog, PCL2, that arose from the whole genome duplication; Belongs to the cyclin family. PCL1,2 subfamily.


ensembl_gene_id: YDL180W
symbol: YDL180W
gene_biotype: protein_coding
description:
  Uncharacterized membrane protein YDL180W; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole.


ensembl_gene_id: YDL181W
symbol: INH1
gene_biotype: protein_coding
description:
  ATPase inhibitor, mitochondrial; Protein that inhibits ATP hydrolysis by the F1F0-ATP synthase; inhibitory function is enhanced by stabilizing proteins Stf1p and Stf2p; has a calmodulin-binding motif and binds calmodulin in vitro; INH1 has a paralog, STF1, that arose from the whole genome duplication.


ensembl_gene_id: YDL182W
symbol: LYS20
gene_biotype: protein_coding
description:
  Homocitrate synthase isozyme and functions in DNA repair; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS20 has a paralog, LYS21, that arose from the whole genome duplication; Belongs to the alpha-IPM synthase/homocitrate synthase family. Homocitrate synthase LYS20/LYS21 subfamily.


ensembl_gene_id: YDL183C
symbol: YDL183C
gene_biotype: protein_coding
description:
  Uncharacterized protein YDL183C; Protein that may form an active mitochondrial KHE system; mitochondrial inner-membrane protein; non-essential gene; KHE system stands for K+/H+ exchanger system; To S.pombe SpAC23H3.12c.


ensembl_gene_id: YDL184C
symbol: RPL41A
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L41A; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41A has a paralog, RPL41B, that arose from the whole genome duplication.


ensembl_gene_id: YDL185C-A
symbol: YDL185C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YDL185C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDL185W; identified by homology with hemiascomycetous yeast species.


ensembl_gene_id: YDL185W
symbol: VMA1
gene_biotype: protein_coding
description:
  Subunit A of the V1 peripheral membrane domain of V-ATPase; protein precursor undergoes self-catalyzed splicing to yield the extein Tfp1p and the intein Vde (PI-SceI), which is a site-specific endonuclease; the V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase) has eight subunits; involved in methionine restriction extension of chronological lifespan in an autophagy-dependent manner; Belongs to the ATPase alpha/beta chains family.


ensembl_gene_id: YDL187C
symbol: YDL187C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YDL187C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YDL188C
symbol: PPH22
gene_biotype: protein_coding
description:
  Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph21p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; protein abundance increases in response to DNA replication stress; dephosphorylates Tel1p/Mec1p-phosphorylated Cdc13p to promote telomerase release from telomeres at G2/M; PPH22 has a paralog, PPH21, that arose from the whole genome duplication; Belongs to the PPP phosphatase family. PP-2A subfamily.


ensembl_gene_id: YDL189W
symbol: RBS1
gene_biotype: protein_coding
description:
  RNA-binding suppressor of PAS kinase protein 1; Protein involved in assembly of the RNA polymerase III (Pol III) complex; high copy suppressor of Pol III assembly mutation and psk1 psk2 mutations that confer temperature-sensitivity for galactose utilization; physically interacts with Pol III; proposed to bind single-stranded nucleic acids via its R3H domain.


ensembl_gene_id: YDL190C
symbol: UFD2
gene_biotype: protein_coding
description:
  E4 ubiquitin-protein ligase UFD2; Ubiquitin chain assembly factor (E4); cooperates with a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin protein ligase (E3) to conjugate ubiquitin to substrates; also functions as an E3.


ensembl_gene_id: YDL191W
symbol: RPL35A
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L35A; homologous to mammalian ribosomal protein L35 and bacterial L29; RPL35A has a paralog, RPL35B, that arose from the whole genome duplication.


ensembl_gene_id: YDL192W
symbol: ARF1
gene_biotype: protein_coding
description:
  ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog, ARF2, that arose from the whole genome duplication; arf1 arf2 double null mutation is complemented by human ARF1, ARF4, ARF5, or ARF6.


ensembl_gene_id: YDL193W
symbol: NUS1
gene_biotype: protein_coding
description:
  Forms dehydrodolichyl diphosphate syntase complex with RER2 or SRT1; tet-repressible mutant shows accumulation of hypoglycosylated forms of CPY, suggesting that Nus1p may be involved in protein trafficking; mutations in human homolog NUS1 have been implicated in congenital scoliosis, neurological impairment, refractory epilepsy, hearing deficit, and visual impairment; human cis-prenyltransferase complex complements yeast null mutant; Belongs to the UPP synthase family.


ensembl_gene_id: YDL194W
symbol: SNF3
gene_biotype: protein_coding
description:
  Plasma membrane low glucose sensor, regulates glucose transport; high affinity sensor that contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; also senses fructose and mannose; SNF3 has a paralog, RGT2, that arose from the whole genome duplication.


ensembl_gene_id: YDL195W
symbol: SEC31
gene_biotype: protein_coding
description:
  Protein transport protein SEC31; Component of the Sec13p-Sec31p complex of the COPII vesicle coat; COPII coat is required for vesicle formation in ER to Golgi transport; mutant has increased aneuploidy tolerance.


ensembl_gene_id: YDL196W
symbol: YDL196W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YDL196W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31.


ensembl_gene_id: YDL198C
symbol: GGC1
gene_biotype: protein_coding
description:
  Mitochondrial GTP/GDP carrier protein 1; Mitochondrial GTP/GDP transporter; essential for mitochondrial genome maintenance; has a role in mitochondrial iron transport; member of the mitochondrial carrier family.


ensembl_gene_id: YDL199C
symbol: YDL199C
gene_biotype: protein_coding
description:
  Putative metabolite transport protein YDL199C; Putative transporter; member of the sugar porter family; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.


ensembl_gene_id: YDL200C
symbol: MGT1
gene_biotype: protein_coding
description:
  DNA repair methyltransferase (6-O-methylguanine-DNA methylase); involved in protection against DNA alkylation damage; Belongs to the MGMT family.


ensembl_gene_id: YDL201W
symbol: TRM8
gene_biotype: protein_coding
description:
  Noncatalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p.


ensembl_gene_id: YDL203C
symbol: ACK1
gene_biotype: protein_coding
description:
  Activator of C kinase protein 1; Protein that functions in the cell wall integrity pathway; functions upstream of Pkc1p; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria.


ensembl_gene_id: YDL204W
symbol: RTN2
gene_biotype: protein_coding
description:
  Reticulon-like protein 2; Reticulon protein; involved in nuclear pore assembly and maintenance of tubular ER morphology; promotes membrane curvature; regulates the ER asymmetry-induced inheritance block during ER stress; role in ER-derived peroxisomal biogenesis; interacts with Sec6p, Yip3p, and Sbh1p; less abundant than RTN1; member of RTNLA (reticulon-like A) subfamily; protein increases in abundance and relocalizes to plasma membrane upon DNA replication stress.


ensembl_gene_id: YDL205C
symbol: HEM3
gene_biotype: protein_coding
description:
  Porphobilinogen deaminase; catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme; human homolog HMBS can complement yeast mutant and allow growth of haploid null after sporulation of a heterozygous diploid.


ensembl_gene_id: YDL206W
symbol: YDL206W
gene_biotype: protein_coding
description:
  Putative protein of unknown function; YDL206W is not an essential protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.


ensembl_gene_id: YDL207W
symbol: GLE1
gene_biotype: protein_coding
description:
  Cytoplasmic nucleoporin required for polyadenylated mRNA export; contains a nuclear export signal; when bound to inositol hexakisphosphate (IP6), functions as an activator for the Dbp5p ATPase activity at the nuclear pore complex during mRNA export; mediates translation initiation; required for efficient translation termination.


ensembl_gene_id: YDL208W
symbol: NHP2
gene_biotype: protein_coding
description:
  H/ACA ribonucleoprotein complex subunit NHP2; Protein related to mammalian high mobility group (HMG) proteins; nuclear protein; essential for function of H/ACA-type snoRNPs, which are involved in 18S rRNA processing; Belongs to the eukaryotic ribosomal protein eL8 family.


ensembl_gene_id: YDL209C
symbol: CWC2
gene_biotype: protein_coding
description:
  Pre-mRNA-splicing factor CWC2; Member of the NineTeen Complex (NTC); this complex contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; binds directly to U6 snRNA; similar to S. pombe Cwf2; Belongs to the RRM CWC2 family.


ensembl_gene_id: YDL210W
symbol: UGA4
gene_biotype: protein_coding
description:
  GABA (gamma-aminobutyrate) permease; serves as a GABA transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane; Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid/choline transporter (ACT) (TC 2.A.3.4) family.


ensembl_gene_id: YDL211C
symbol: YDL211C
gene_biotype: protein_coding
description:
  Uncharacterized protein YDL211C; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YDL211C has a paralog, TDA7, that arose from the whole genome duplication.


ensembl_gene_id: YDL212W
symbol: SHR3
gene_biotype: protein_coding
description:
  Secretory component protein SHR3; Endoplasmic reticulum packaging chaperone; required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface.


ensembl_gene_id: YDL213C
symbol: NOP6
gene_biotype: protein_coding
description:
  Nucleolar protein 6; rRNA-binding protein required for 40S ribosomal subunit biogenesis; contains an RNA recognition motif (RRM); hydrophilin essential to overcome the stress of the desiccation-rehydration process; NOP6 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes.


ensembl_gene_id: YDL214C
symbol: PRR2
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase PRR2; Serine/threonine protein kinase; inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor; mutant has increased aneuploidy tolerance; PRR2 has a paralog, NPR1, that arose from the whole genome duplication.


ensembl_gene_id: YDL215C
symbol: GDH2
gene_biotype: protein_coding
description:
  NAD(+)-dependent glutamate dehydrogenase; degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levels; genetically interacts with GDH3 by suppressing stress-induced apoptosis.


ensembl_gene_id: YDL216C
symbol: RRI1
gene_biotype: protein_coding
description:
  Catalytic subunit of the COP9 signalosome (CSN) complex; acts as an isopeptidase in cleaving the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; metalloendopeptidase involved in the adaptation to pheromone signaling; involved in modulation of genes controlling amino acid and lipid metabolism, and ergosterol biosynthesis; Belongs to the peptidase M67A family. CSN5 subfamily.


ensembl_gene_id: YDL217C
symbol: TIM22
gene_biotype: protein_coding
description:
  Mitochondrial import inner membrane translocase subunit TIM22; Essential core component of the mitochondrial TIM22 complex; involved in insertion of polytopic proteins into the inner membrane; forms the channel through which proteins are imported; Belongs to the Tim17/Tim22/Tim23 family.


ensembl_gene_id: YDL218W
symbol: YDL218W
gene_biotype: protein_coding
description:
  Putative protein of unknown function; YDL218W transcription is regulated by Azf1p and induced by starvation and aerobic conditions; expression also induced in cells treated with the mycotoxin patulin.


ensembl_gene_id: YDL219W
symbol: DTD1
gene_biotype: protein_coding
description:
  D-Tyr-tRNA(Tyr) deacylase; functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery; ubiquitous among eukaryotes; Belongs to the DTD family.


ensembl_gene_id: YDL220C
symbol: CDC13
gene_biotype: protein_coding
description:
  Cell division control protein 13; Single stranded DNA-binding protein found at TG1-3 telomere G-tails; key roles in regulation of telomerase, telomere end protection, conventional telomere replication; regulates telomere replication through recruitment of specific sub-complexes, essential function is telomere capping; forms homodimer via N-terminus; disruption of dimerization leads to short telomeres; autophagy and proteasome are involved in Cdc13p degradation; differentially phosphorylated through cell cycle.


ensembl_gene_id: YDL221W
symbol: YDL221W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YDL221W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the 3' end of essential gene CDC13.


ensembl_gene_id: YDL222C
symbol: FMP45
gene_biotype: protein_coding
description:
  SUR7 family protein FMP45; Integral membrane protein localized to mitochondria; required for sporulation and maintaining sphingolipid content; similar to SUR7; FMP45 has a paralog, YNL194C, that arose from the whole genome duplication.


ensembl_gene_id: YDL223C
symbol: HBT1
gene_biotype: protein_coding
description:
  Shmoo tip protein, substrate of Hub1p ubiquitin-like protein; mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis; HBT1 has a paralog, YNL195C, that arose from the whole genome duplication.


ensembl_gene_id: YDL224C
symbol: WHI4
gene_biotype: protein_coding
description:
  Protein WHI4; Putative RNA binding protein; regulates the cell size requirement for passage through Start and commitment to cell division; WHI4 has a paralog, WHI3, that arose from the whole genome duplication.


ensembl_gene_id: YDL225W
symbol: SHS1
gene_biotype: protein_coding
description:
  Seventh homolog of septin 1; Component of the septin ring that is required for cytokinesis; present at the ends of rod-like septin hetero-oligomers; C-terminal extension is important for recruitment of Bni5p to the mother-bud neck, which in turn is required for Myo1p recruitment and cytokinesis; undergoes sumoylation and phosphorylation during mitosis; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YDL226C
symbol: GCS1
gene_biotype: protein_coding
description:
  ADP-ribosylation factor GTPase activating protein (ARF GAP); involved in ER-Golgi transport; required for prospore membrane formation; regulates phospholipase Spo14p; shares functional similarity with Glo3p; GCS1 has a paralog, SPS18, that arose from the whole genome duplication.


ensembl_gene_id: YDL227C
symbol: HO
gene_biotype: protein_coding
description:
  Homothallic switching endonuclease; Site-specific endonuclease; required for gene conversion at the MAT locus (homothallic switching) through the generation of a ds DNA break; expression restricted to mother cells in late G1 as controlled by Swi4p-Swi6p, Swi5p, and Ash1p.


ensembl_gene_id: YDL228C
symbol: YDL228C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YDL228C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene SSB1.


ensembl_gene_id: YDL229W
symbol: SSB1
gene_biotype: protein_coding
description:
  Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in folding of newly-made polypeptide chains; member of the HSP70 family; interacts with phosphatase subunit Reg1p; SSB1 has a paralog, SSB2, that arose from the whole genome duplication; Belongs to the heat shock protein 70 family. Ssb-type Hsp70 subfamily.


ensembl_gene_id: YDL230W
symbol: PTP1
gene_biotype: protein_coding
description:
  Tyrosine-protein phosphatase 1; Phosphotyrosine-specific protein phosphatase; dephosphorylates a broad range of substrates in vivo, including Fpr3p; localized to the cytoplasm and the mitochondria; proposed to be a negative regulator of filamentation; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily.


ensembl_gene_id: YDL231C
symbol: BRE4
gene_biotype: protein_coding
description:
  Zinc finger protein containing five transmembrane domains; null mutant exhibits strongly fragmented vacuoles and sensitivity to brefeldin A, a drug which is known to affect intracellular transport.


ensembl_gene_id: YDL232W
symbol: OST4
gene_biotype: protein_coding
description:
  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST4; Subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes protein asparagine-linked glycosylation; type I membrane protein required for incorporation of Ost3p or Ost6p into the OST complex; Belongs to the OST4 family.


ensembl_gene_id: YDL233W
symbol: MFG1
gene_biotype: protein_coding
description:
  Regulator of filamentous growth; interacts with FLO11 promoter and regulates FLO11 expression; binds to transcription factors Flo8p and Mss11p; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YDL233W is not an essential gene; Belongs to the MFG1 family.


ensembl_gene_id: YDL234C
symbol: GYP7
gene_biotype: protein_coding
description:
  GTPase-activating protein for yeast Rab family members; members include Ypt7p (most effective), Ypt1p, Ypt31p, and Ypt32p (in vitro); involved in vesicle mediated protein trafficking; contains a PH-like domain.


ensembl_gene_id: YDL235C
symbol: YPD1
gene_biotype: protein_coding
description:
  Osmotic stress-responsive phosphorelay intermediate sensor protein; phosphorylated by the plasma membrane sensor Sln1p in response to osmotic stress and then in turn phosphorylates the response regulators Ssk1p in the cytosol and Skn7p in the nucleus; Belongs to the YPD1 family.


ensembl_gene_id: YDL236W
symbol: PHO13
gene_biotype: protein_coding
description:
  4-nitrophenylphosphatase; Conserved phosphatase acting as a metabolite repair enzyme; shows specific dephosphorylating activity on two side-products of central carbohydrate metabolism, 2-phosphoglycolate and 4-phosphoerythronate; alkaline phosphatase specific for p-nitrophenyl phosphate; also has protein phosphatase activity; human ortholog PGP shows similar substrate specificity, deletion causes similar metabolite accumulation phenotypes, suggesting conserved role in eliminating glycolytic byproducts.


ensembl_gene_id: YDL237W
symbol: AIM6
gene_biotype: protein_coding
description:
  Altered inheritance of mitochondria protein 6; Protein of unknown function; required for respiratory growth; YDL237W is not an essential gene.


ensembl_gene_id: YDL238C
symbol: GUD1
gene_biotype: protein_coding
description:
  Guanine deaminase; a catabolic enzyme of the guanine salvage pathway producing xanthine and ammonia from guanine; activity is low in exponentially-growing cultures but expression is increased in post-diauxic and stationary-phase cultures.


ensembl_gene_id: YDL239C
symbol: ADY3
gene_biotype: protein_coding
description:
  Accumulates dyads protein 3; Protein required for spore wall formation; subunit of the leading edge protein (LEP) complex (Ssp1-Ady3-Don1-Irc10) that forms a ring-like structure at the leading edge of the prospore membrane during meiosis II; mediates assembly of the LEP complex, formation of the ring-like structure via interaction with spindle pole body components and prospore membrane maturation; potentially phosphorylated by Cdc28p; ADY3 has a paralog, CNM67, that arose from the whole.


ensembl_gene_id: YDL240C-A
symbol: YDL240C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YDL240C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by sequence comparison with hemiascomycetous yeast species.


ensembl_gene_id: YDL240W
symbol: LRG1
gene_biotype: protein_coding
description:
  Rho-GTPase-activating protein LRG1; GTPase-activating protein (GAP); contains Rho1p-specific GAP activity, interacting with activated forms of Rho1p; functions along with Sac7p as a negative regulator of the Pkc1p-mediated cell wall integrity signaling pathway; negative regulator of cell wall 1,3-beta-glucan biosynthesis; required for efficient cell fusion; contains a RhoGAP domain and three Lin-11-Isl1-Mec-3 (LIM) domains.


ensembl_gene_id: YDL241W
symbol: YDL241W
gene_biotype: protein_coding
description:
  Uncharacterized protein YDL241W; Putative protein of unknown function; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum; YDL241W is not an essential gene.


ensembl_gene_id: YDL242W
symbol: YDL242W
gene_biotype: protein_coding
description:
  Uncharacterized protein YDL242W; Putative protein of unknown function; conserved across S. cerevisiae strains.


ensembl_gene_id: YDL243C
symbol: AAD4
gene_biotype: protein_coding
description:
  Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin; members of the AAD gene family comprise three pairs (AAD3 + AAD15, AAD6/AAD16 + AAD4, AAD10 + AAD14) whose two genes are more related to one another than to other members of the family.


ensembl_gene_id: YDL244W
symbol: THI13
gene_biotype: protein_coding
description:
  4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase THI13; Protein involved in synthesis of the thiamine precursor HMP; member of a subtelomeric gene family including THI5, THI11, THI12, and THI13; hydroxymethylpyrimidine is also known as HMP.


ensembl_gene_id: YDL245C
symbol: HXT15
gene_biotype: protein_coding
description:
  Hexose transporter HXT15; Putative transmembrane polyol transporter; supports growth on and uptake of mannitol, sorbitol and xylitol with moderate affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; similarity to hexose transporters; expression is induced by low levels of glucose and repressed by high levels of glucose; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.


ensembl_gene_id: YDL247W
symbol: MPH2
gene_biotype: protein_coding
description:
  Alpha-glucosides permease MPH2; Alpha-glucoside permease; transports maltose, maltotriose, alpha-methylglucoside, and turanose; almost identical to Mph3p; encoded in a subtelomeric position in a region likely to have undergone duplication.


ensembl_gene_id: YDL247W-A
symbol: YDL247W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YDL247W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by sequence comparison with hemiascomycetous yeast species.


ensembl_gene_id: YDL248W
symbol: COS7
gene_biotype: protein_coding
description:
  Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies.


ensembl_gene_id: YDR001C
symbol: NTH1
gene_biotype: protein_coding
description:
  Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; phosphorylated and activated by Cdc28p at the G1/S phase transition to coordinately regulate carbohydrate metabolism and the cell cycle; inhibited by Dcs1p; NTH1 has a paralog, NTH2, that arose from the whole genome duplication; Belongs to the glycosyl hydrolase 37 family.


ensembl_gene_id: YDR002W
symbol: YRB1
gene_biotype: protein_coding
description:
  Ran-specific GTPase-activating protein 1; Ran GTPase binding protein; involved in nuclear protein import and RNA export, ubiquitin-mediated protein degradation during the cell cycle; shuttles between the nucleus and cytoplasm; is essential; homolog of human RanBP1.


ensembl_gene_id: YDR003W
symbol: RCR2
gene_biotype: protein_coding
description:
  Vacuolar protein; presumably functions within the endosomal-vacuolar trafficking pathway, affecting events that determine whether plasma membrane proteins are degraded or routed to the plasma membrane; RCR2 has a paralog, RCR1, that arose from the whole genome duplication.


ensembl_gene_id: YDR003W-A
symbol: YDR003W-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YDR003W-A; Putative protein of unknown function; identified by expression profiling and mass spectrometry.


ensembl_gene_id: YDR004W
symbol: RAD57
gene_biotype: protein_coding
description:
  DNA repair protein RAD57; Protein that stimulates strand exchange; stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad55p; Belongs to the RecA family.


ensembl_gene_id: YDR005C
symbol: MAF1
gene_biotype: protein_coding
description:
  Highly conserved negative regulator of RNA polymerase III; involved in tRNA processing and stability; inhibits tRNA degradation via rapid tRNA decay (RTD) pathway; binds N-terminal domain of Rpc160p subunit of Pol III to prevent closed-complex formation; regulated by phosphorylation mediated by TORC1, protein kinase A, Sch9p, casein kinase 2; localizes to cytoplasm during vegetative growth and translocates to nucleus and nucleolus under stress conditions.


ensembl_gene_id: YDR006C
symbol: SOK1
gene_biotype: protein_coding
description:
  Protein of unknown function; overexpression suppresses the growth defect of mutants lacking protein kinase A activity; involved in cAMP-mediated signaling; localized to the nucleus; similar to the mouse testis-specific protein PBS13; Belongs to the TCP11 family.


ensembl_gene_id: YDR007W
symbol: TRP1
gene_biotype: protein_coding
description:
  Phosphoribosylanthranilate isomerase; catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA); enhances vegetative growth at low and high temperatures when used as an auxotrophic marker in strains such as W303.


ensembl_gene_id: YDR008C
symbol: YDR008C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YDR008C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps TRP1/YDR007W on opposite strand.


ensembl_gene_id: YDR009W
symbol: GAL3
gene_biotype: protein_coding
description:
  Protein GAL3; Transcriptional regulator; involved in activation of the GAL genes in response to galactose; forms a complex with Gal80p to relieve Gal80p inhibition of Gal4p; binds galactose and ATP but does not have galactokinase activity; GAL3 has a paralog, GAL1, that arose from the whole genome duplication; Belongs to the GHMP kinase family. GalK subfamily.


ensembl_gene_id: YDR010C
symbol: YDR010C
gene_biotype: protein_coding
description:
  Uncharacterized protein YDR010C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YDR011W
symbol: SNQ2
gene_biotype: protein_coding
description:
  Protein SNQ2; Plasma membrane ATP-binding cassette (ABC) transporter; multidrug transporter involved in multidrug resistance and resistance to singlet oxygen species; Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.


ensembl_gene_id: YDR012W
symbol: RPL4B
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L4B; homologous to mammalian ribosomal protein L4 and bacterial L4; RPL4B has a paralog, RPL4A, that arose from the whole genome duplication.


ensembl_gene_id: YDR013W
symbol: PSF1
gene_biotype: protein_coding
description:
  Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p); complex is localized to DNA replication origins and implicated in assembly of the DNA replication machinery.


ensembl_gene_id: YDR014W
symbol: RAD61
gene_biotype: protein_coding
description:
  Protein RAD61; Subunit of a complex that inhibits sister chromatid cohesion; also negatively regulates chromosome condensation; inhibited by Eco1p-acetylated cohesin subunits Smc3p and Mcd1p; binds Smc3p ATPase head of cohesin; related to the human Wapl protein that controls the association of cohesin with chromatin.


ensembl_gene_id: YDR014W-A
symbol: HED1
gene_biotype: protein_coding
description:
  Meiosis-specific protein; down-regulates Rad51p-mediated mitotic recombination when the meiotic recombination machinery is impaired; promotes synapsis and required for the normal morphogenesis of synaptonemal complex; prevents the recruitment of Rad54p to site-specific DNA double-strand breaks in vivo; early meiotic gene, transcribed specifically during meiotic prophase.


ensembl_gene_id: YDR015C
symbol: YDR015C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YDR015C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene HED1/YDR014W-A.


ensembl_gene_id: YDR017C
symbol: KCS1
gene_biotype: protein_coding
description:
  Inositol hexakisphosphate and inositol heptakisphosphate kinase; generation of high energy inositol pyrophosphates by Kcs1p is required for many processes such as vacuolar biogenesis, stress response, RNA polymerase I-mediated rRNA transcription and telomere maintenance; inositol hexakisphosphate is also known as IP6; inositol heptakisphosphate is also known as IP7; Belongs to the inositol phosphokinase (IPK) family.


ensembl_gene_id: YDR018C
symbol: YDR018C
gene_biotype: protein_coding
description:
  Uncharacterized acyltransferase YDR018C; Probable membrane protein with three predicted transmembrane domains; similar to C. elegans F55A11.5 and maize 1-acyl-glycerol-3-phosphate acyltransferase; YDR018C has a paralog, CST26, that arose from the whole genome duplication.


ensembl_gene_id: YDR019C
symbol: GCV1
gene_biotype: protein_coding
description:
  T subunit of the mitochondrial glycine decarboxylase complex; glycine decarboxylase is required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm.


ensembl_gene_id: YDR020C
symbol: DAS2
gene_biotype: protein_coding
description:
  Putative uridine kinase DAS2; Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; weak similarity with uridine kinases and with phosphoribokinases; Belongs to the uridine kinase family.


ensembl_gene_id: YDR021W
symbol: FAL1
gene_biotype: protein_coding
description:
  ATP-dependent RNA helicase FAL1; Nucleolar protein required for maturation of 18S rRNA; member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases; 18S rRNA biogenesis defect of the null mutant is functionally complemented by human EIF4A3; Belongs to the DEAD box helicase family. DDX48/FAL1 subfamily.


ensembl_gene_id: YDR022C
symbol: ATG31
gene_biotype: protein_coding
description:
  Autophagy-related protein 31; Autophagy-specific protein required for autophagosome formation; forms a complex with Atg17p and Atg29p that localizes other proteins to the pre-autophagosomal structure; constitutively phosphorylated, and phosphorylation of residue S174 is required for function; high-copy suppressor of CIK1 deletion.


ensembl_gene_id: YDR023W
symbol: SES1
gene_biotype: protein_coding
description:
  Serine--tRNA ligase, cytoplasmic; Cytosolic seryl-tRNA synthetase; class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p.


ensembl_gene_id: YDR024W
symbol: FYV1
gene_biotype: protein_coding
description:
  Putative uncharacterized protein FYV1; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; mutation decreases survival upon exposure to K1 killer toxin.


ensembl_gene_id: YDR025W
symbol: RPS11A
gene_biotype: protein_coding
description:
  Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S11 and bacterial S17; N-terminally propionylated in vivo; RPS11A has a paralog, RPS11B, that arose from the whole genome duplication.


ensembl_gene_id: YDR026C
symbol: NSI1
gene_biotype: protein_coding
description:
  RNA polymerase I termination factor; binds to rDNA terminator element, required for efficient Pol I termination; required for rDNA silencing at NTS1; facilities association of Sir2p with NTS1, contributes to rDNA stability and cell longevity; interacts physically with Fob1p and RENT subunits, Sir2p and Net1p; may interact with ribosomes, based on co-purification experiments; Myb-like DNA-binding protein; NSI1 has a paralog, REB1, that arose from the whole genome duplication.


ensembl_gene_id: YDR027C
symbol: VPS54
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 54; Component of the GARP (Golgi-associated retrograde protein) complex; GARP is required for the recycling of proteins from endosomes to the late Golgi, and for mitosis after DNA damage induced checkpoint arrest; potentially phosphorylated by Cdc28p; members of the GARP complex are Vps51p-Vps52p-Vps53p-Vps54p.


ensembl_gene_id: YDR028C
symbol: REG1
gene_biotype: protein_coding
description:
  Regulatory subunit of type 1 protein phosphatase Glc7p; involved in negative regulation of glucose-repressible genes; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; REG1 has a paralog, REG2, that arose from the whole genome duplication.


ensembl_gene_id: YDR029W
symbol: YDR029W
gene_biotype: protein_coding
description:
  Uncharacterized protein YDR029W; Putative protein of unknown function; conserved among S. cerevisiae strains; YDR029W is not an essential gene.


ensembl_gene_id: YDR030C
symbol: RAD28
gene_biotype: protein_coding
description:
  Radiation-sensitive protein 28; Protein involved in DNA repair; related to the human CSA protein that is involved in transcription-coupled repair nucleotide excision repair.


ensembl_gene_id: YDR031W
symbol: MIX14
gene_biotype: protein_coding
description:
  Mitochondrial intermembrane space protein of unknown function; required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YDR032C
symbol: PST2
gene_biotype: protein_coding
description:
  Protoplast secreted protein 2; Protein with similarity to a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; PST2 has a paralog, RFS1, that arose from the whole genome duplication.


ensembl_gene_id: YDR033W
symbol: MRH1
gene_biotype: protein_coding
description:
  Protein that localizes primarily to the plasma membrane; also found at the nuclear envelope; long-lived protein that is asymmetrically retained in the plasma membrane of mother cells; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; null mutation confers sensitivity to acetic acid; Belongs to the archaeal/bacterial/fungal opsin family.


ensembl_gene_id: YDR034C
symbol: LYS14
gene_biotype: protein_coding
description:
  Lysine biosynthesis regulatory protein LYS14; Transcriptional activator involved in regulating lysine biosynthesis; involved in the regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer.


ensembl_gene_id: YDR034W-B
symbol: YDR034W-B
gene_biotype: protein_coding
description:
  Cysteine-rich and transmembrane domain-containing protein YDR034W-B; Predicted tail-anchored plasma membrane protein; contains conserved CYSTM module; related proteins in other organisms may be involved in response to stress; N- and C-terminal fusion proteins localize to the cell periphery; YDR034W-B has a paralog, YBR056W-A, that arose from the whole genome duplication; Belongs to the CYSTM1 family.


ensembl_gene_id: YDR035W
symbol: ARO3
gene_biotype: protein_coding
description:
  Phospho-2-dehydro-3-deoxyheptonate aldolase, phenylalanine-inhibited; 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase; catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan.


ensembl_gene_id: YDR036C
symbol: EHD3
gene_biotype: protein_coding
description:
  3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; 3-hydroxyisobutyryl-CoA hydrolase; member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosis.


ensembl_gene_id: YDR038C
symbol: ENA5
gene_biotype: protein_coding
description:
  Protein with similarity to P-type ATPase sodium pumps; member of the Na+ efflux ATPase family; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IID subfamily.


ensembl_gene_id: YDR039C
symbol: ENA2
gene_biotype: protein_coding
description:
  P-type ATPase sodium pump; involved in Na+ efflux to allow salt tolerance; likely not involved in Li+ efflux; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IID subfamily.


ensembl_gene_id: YDR041W
symbol: RSM10
gene_biotype: protein_coding
description:
  Mitochondrial ribosomal protein of the small subunit; has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins.


ensembl_gene_id: YDR042C
symbol: YDR042C
gene_biotype: protein_coding
description:
  Uncharacterized protein YDR042C; Putative protein of unknown function; expression is increased in ssu72-ts69 mutant.


ensembl_gene_id: YDR043C
symbol: NRG1
gene_biotype: protein_coding
description:
  Transcriptional regulator NRG1; Transcriptional repressor; recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response; activated in stochastic pulses of nuclear localization in response to low glucose.


ensembl_gene_id: YDR044W
symbol: HEM13
gene_biotype: protein_coding
description:
  Oxygen-dependent coproporphyrinogen-III oxidase; Coproporphyrinogen III oxidase; oxygen-requiring enzyme that catalyzes sixth step in heme biosynthetic pathway; transcription is repressed by oxygen and heme (via Rox1p and Hap1p); human homolog CPOX can complement yeast mutant and allow growth of haploid null after sporulation of a heterozygous diploid; Belongs to the aerobic coproporphyrinogen-III oxidase family.


ensembl_gene_id: YDR045C
symbol: RPC11
gene_biotype: protein_coding
description:
  RNA polymerase III subunit C11; mediates pol III RNA cleavage activity and is important for termination of transcription; homologous to TFIIS.


ensembl_gene_id: YDR046C
symbol: BAP3
gene_biotype: protein_coding
description:
  Valine amino-acid permease; Amino acid permease; involved in uptake of cysteine, leucine, isoleucine and valine; BAP3 has a paralog, BAP2, that arose from the whole genome duplication; Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.


ensembl_gene_id: YDR047W
symbol: HEM12
gene_biotype: protein_coding
description:
  Uroporphyrinogen decarboxylase; catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda.


ensembl_gene_id: YDR048C
symbol: YDR048C
gene_biotype: protein_coding
description:
  Putative uncharacterized membrane protein YDR048C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps ORF VMS1/YDR049W.


ensembl_gene_id: YDR049W
symbol: VMS1
gene_biotype: protein_coding
description:
  Protein VMS1; Component of a Cdc48p-complex involved in protein quality control; exhibits cytosolic and ER-membrane localization, with Cdc48p, during normal growth, and contributes to ER-associated degradation (ERAD) of specific substrates at a step after their ubiquitination; forms a mitochondrially-associated complex with Cdc48p and Npl4p under oxidative stress that is required for ubiquitin-mediated mitochondria-associated protein degradation (MAD); conserved in C. elegans and humans; Belongs to the ANKZF1/VMS1 family.


ensembl_gene_id: YDR050C
symbol: TPI1
gene_biotype: protein_coding
description:
  Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding region; inhibition of Tpi1p activity by PEP (phosphoenolpyruvate) stimulates redox metabolism in respiring cells; E104D mutation in human homolog TPI1 causes a rare autosomal disease; human TPI1 can complement yeast null mutant.


ensembl_gene_id: YDR051C
symbol: DET1
gene_biotype: protein_coding
description:
  Acid phosphatase; involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel; Belongs to the phosphoglycerate mutase family.


ensembl_gene_id: YDR052C
symbol: DBF4
gene_biotype: protein_coding
description:
  Regulatory subunit of Cdc7p-Dbf4p kinase complex; required for Cdc7p kinase activity and initiation of DNA replication; phosphorylates the Mcm2-7 family of proteins; cell cycle regulated; relative distribution to the nucleus increases upon DNA replication stress; co-expression of human CDC7 and DBF4 complements single cdc7 or dbf4 null mutations or the cdc7 dbf4 double null mutation.


ensembl_gene_id: YDR053W
symbol: YDR053W
gene_biotype: protein_coding
description:
  Putative protein of unknown function; open reading frame overlaps 5' end of essential DBF4 gene encoding the regulatory subunit of the Cdc7p-Dbf4p kinase complex.


ensembl_gene_id: YDR054C
symbol: CDC34
gene_biotype: protein_coding
description:
  Ubiquitin-conjugating enzyme (E2); catalytic subunit of SCF ubiquitin-protein ligase complex (together with Skp1p, Rbx1p, Cdc53p, and an F-box protein) that regulates cell cycle progression by targeting key substrates for degradation; protein abundance increases in response to DNA replication stress; human CDC34 functionally complements the thermosensitivity of the cdc34-2 mutant.


ensembl_gene_id: YDR055W
symbol: PST1
gene_biotype: protein_coding
description:
  Cell wall protein that contains a putative GPI-attachment site; secreted by regenerating protoplasts; up-regulated by activation of the cell integrity pathway, as mediated by Rlm1p; upregulated by cell wall damage via disruption of FKS1; PST1 has a paralog, ECM33, that arose from the whole genome duplication; Belongs to the SPS2 family.


ensembl_gene_id: YDR056C
symbol: EMC10
gene_biotype: protein_coding
description:
  Putative protein of unknown function; subunit of evolutionarily conserved EMC (Endoplasmic Reticulum Membrane Complex) implicated in ERAD (ER-associated degradation) and proper assembly of multi-pass transmembrane (TM) proteins; EMC acts in yeast as an ER-mitochondria tether that interacts with outer membrane protein Tom5p of TOM (Translocase of the Mitochondrial Outer Membrane) complex; YDR056C is not an essential protein.


ensembl_gene_id: YDR057W
symbol: YOS9
gene_biotype: protein_coding
description:
  Protein OS-9 homolog; ER quality-control lectin; integral subunit of the HRD ligase; participates in efficient ER retention of misfolded proteins by recognizing them and delivering them to Hrd1p; binds to glycans with terminal alpha-1,6 linked mannose on misfolded N-glycosylated proteins and participates in targeting proteins to ERAD; member of the OS-9 protein family.


ensembl_gene_id: YDR058C
symbol: TGL2
gene_biotype: protein_coding
description:
  Lipase 2; Triacylglycerol lipase that is localized to the mitochondria; has lipolytic activity towards triacylglycerols and diacylglycerols when expressed in E. coli.


ensembl_gene_id: YDR059C
symbol: UBC5
gene_biotype: protein_coding
description:
  Ubiquitin-conjugating enzyme; mediates selective degradation of short-lived, abnormal, or excess proteins, including histone H3; central component of the cellular stress response; expression is heat inducible; protein abundance increases in response to DNA replication stress; UBC5 has a paralog, UBC4, that arose from the whole genome duplication.


ensembl_gene_id: YDR060W
symbol: MAK21
gene_biotype: protein_coding
description:
  Ribosome biogenesis protein MAK21; Constituent of 66S pre-ribosomal particles; required for large (60S) ribosomal subunit biogenesis; acts as part of a Mak21p-Noc2p-Rrp5p module that associates with nascent pre-rRNA during transcription and has a role in bigenesis of the large ribosomal subunit; involved in nuclear export of pre-ribosomes; required for maintenance of dsRNA virus; homolog of human CAATT-binding protein.


ensembl_gene_id: YDR061W
symbol: YDR061W
gene_biotype: protein_coding
description:
  Protein with similarity to ABC transporter family members; lacks predicted membrane-spanning regions; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance.


ensembl_gene_id: YDR062W
symbol: LCB2
gene_biotype: protein_coding
description:
  Component of serine palmitoyltransferase; responsible along with Lcb1p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.


ensembl_gene_id: YDR063W
symbol: AIM7
gene_biotype: protein_coding
description:
  Protein that interacts with Arp2/3 complex; interacts with Arp2/3 complex to stimulate actin filament debranching and inhibit actin nucleation; has similarity to Cof1p and also to human glia maturation factor (GMF); null mutant displays elevated mitochondrial genome loss; Belongs to the actin-binding proteins ADF family. GMF subfamily.


ensembl_gene_id: YDR064W
symbol: RPS13
gene_biotype: protein_coding
description:
  Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S13 and bacterial S15.


ensembl_gene_id: YDR065W
symbol: RRG1
gene_biotype: protein_coding
description:
  Protein of unknown function; required for vacuolar acidification and mitochondrial genome maintenance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Belongs to the RRG1 family.


ensembl_gene_id: YDR066C
symbol: RTR2
gene_biotype: protein_coding
description:
  RNA polymerase II subunit B1 CTD phosphatase RTR2; Protein of unknown function; exhibits genetic interactions with Rtr1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YDR066C is not an essential gene; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress; RTR2 has a paralog, RTR1, that arose from the whole genome duplication.


ensembl_gene_id: YDR067C
symbol: OCA6
gene_biotype: protein_coding
description:
  Putative tyrosine-protein phosphatase OCA6; Cytoplasmic protein required for replication of Brome mosaic virus; S. cerevisiae is a model system for studying positive-strand RNA virus replication; null mutation confers sensitivity to tunicamycin and DTT.


ensembl_gene_id: YDR068W
symbol: DOS2
gene_biotype: protein_coding
description:
  Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm.


ensembl_gene_id: YDR069C
symbol: DOA4
gene_biotype: protein_coding
description:
  Ubiquitin hydrolase; deubiquitinates intralumenal vesicle (ILVs) cargo proteins; required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins destined for the vacuole; DOA4 has a paralog, UBP5, that arose from the whole genome duplication; Belongs to the peptidase C19 family.


ensembl_gene_id: YDR070C
symbol: FMP16
gene_biotype: protein_coding
description:
  Protein FMP16, mitochondrial; Protein of unknown function; may be involved in responding to conditions of stress; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YDR071C
symbol: PAA1
gene_biotype: protein_coding
description:
  Polyamine N-acetyltransferase 1; Polyamine acetyltransferase; acetylates polyamines (e.g. putrescine, spermidine, spermine) and also aralkylamines (e.g. tryptamine, phenylethylamine); may be involved in transcription and/or DNA replication; Belongs to the acetyltransferase family. AANAT subfamily.


ensembl_gene_id: YDR072C
symbol: IPT1
gene_biotype: protein_coding
description:
  Inositolphosphotransferase; involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), the most abundant sphingolipid; can mutate to resistance to the antifungals syringomycin E and DmAMP1 and to K. lactis zymocin.


ensembl_gene_id: YDR073W
symbol: SNF11
gene_biotype: protein_coding
description:
  Transcription regulatory protein SNF11; Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; interacts with a highly conserved 40-residue sequence of Snf2p; relocates to the cytosol under hypoxic conditions.


ensembl_gene_id: YDR074W
symbol: TPS2
gene_biotype: protein_coding
description:
  Trehalose-phosphatase; Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex; involved in synthesis of the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway; protein abundance increases in response to DNA replication stress; In the N-terminal section; belongs to the glycosyltransferase 20 family.


ensembl_gene_id: YDR075W
symbol: PPH3
gene_biotype: protein_coding
description:
  Catalytic subunit of protein phosphatase PP4 complex; Pph3p and Psy2p form active complex, Psy4p may provide substrate specificity; regulates recovery from the DNA damage checkpoint, the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair and efficient Non-Homologous End-Joining (NHEJ) pathway; involved in activation of Gln3p to alleviate nitrogen catabolite repression; Pph3p and Psy2p localize to foci on meiotic chromosomes.


ensembl_gene_id: YDR076W
symbol: RAD55
gene_biotype: protein_coding
description:
  DNA repair protein RAD55; Protein that stimulates strand exchange; stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57p; Belongs to the RecA family. RAD55 subfamily.


ensembl_gene_id: YDR077W
symbol: SED1
gene_biotype: protein_coding
description:
  Cell wall protein SED1; Major stress-induced structural GPI-cell wall glycoprotein; associates with translating ribosomes, possible role in mitochondrial genome maintenance; ORF contains two distinct variable minisatellites; SED1 has a paralog, SPI1, that arose from the whole genome duplication.


ensembl_gene_id: YDR078C
symbol: SHU2
gene_biotype: protein_coding
description:
  Suppressor of hydroxyurea sensitivity protein 2; Component of Shu complex (aka PCSS complex); Shu complex also includes Psy3, Csm2, Shu1, and promotes error-free DNA repair, Shu complex mediates inhibition of Srs2p function; promotes formation of Rad51p filaments; important for both mitotic and meiotic homologous recombination, and contains a conserved SWIM domain that is necessary for both.


ensembl_gene_id: YDR079C-A
symbol: TFB5
gene_biotype: protein_coding
description:
  Component of RNA polymerase II general transcription factor TFIIH; involved in transcription initiation and in nucleotide-excision repair; relocalizes to the cytosol in response to hypoxia; homolog of Chlamydomonas reinhardtii REX1-S protein involved in DNA repair; Belongs to the TFB5 family.


ensembl_gene_id: YDR079W
symbol: PET100
gene_biotype: protein_coding
description:
  Protein PET100, mitochondrial; Chaperone that facilitates the assembly of cytochrome c oxidase; integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme.


ensembl_gene_id: YDR080W
symbol: VPS41
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 41; Subunit of the HOPS endocytic tethering complex; vacuole membrane protein that functions as a Rab GTPase effector, interacting specifically with the GTP-bound conformation of Ypt7p, facilitating tethering, docking and promoting membrane fusion events at the late endosome and vacuole; required for both membrane and protein trafficking; Yck3p-mediated phosphorylation regulates the organization of vacuolar fusion sites.


ensembl_gene_id: YDR081C
symbol: PDC2
gene_biotype: protein_coding
description:
  Protein PDC2; Transcription factor for thiamine-regulated genes; required for expression of the two isoforms of pyruvate decarboxylase (PDC1 and PDC5) along with thiamine biosynthetic genes; binds a DNA sequence in the PDC5 promoter; mutant fails to grow on 2% glucose and thus is scored as inviable under standard conditions.


ensembl_gene_id: YDR082W
symbol: STN1
gene_biotype: protein_coding
description:
  Protein STN1; Telomere end-binding and capping protein; plays a key role with Pol12p in linking telomerase action with completion of lagging strand synthesis, and in a regulatory step required for telomere capping; similar to human Stn1.


ensembl_gene_id: YDR083W
symbol: RRP8
gene_biotype: protein_coding
description:
  25S rRNA (adenine(645)-N(1))-methyltransferase; Nucleolar S-adenosylmethionine-dependent rRNA methyltransferase; methylates adenine (m1A) of the large subunit (LSU) rRNA at position 645; involved in pre-rRNA cleavage at site A2; mutation is synthetically lethal with a gar1 mutation; deletion disrupts telomere maintenance by influencing the expression of neighboring gene STN1; Belongs to the methyltransferase superfamily. RRP8 family.


ensembl_gene_id: YDR084C
symbol: TVP23
gene_biotype: protein_coding
description:
  Integral membrane protein; localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; Belongs to the TVP23 family.


ensembl_gene_id: YDR085C
symbol: AFR1
gene_biotype: protein_coding
description:
  Protein required for pheromone-induced projection (shmoo) formation; regulates septin architecture during mating; has an RVXF motif that mediates targeting of Glc7p to mating projections; interacts with Cdc12p; AFR1 has a paralog, YER158C, that arose from the whole genome duplication; To yeast YER158C.


ensembl_gene_id: YDR086C
symbol: SSS1
gene_biotype: protein_coding
description:
  Protein transport protein SSS1; Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p); this complex forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p); interacts with Ost4p and Wbp1p; Belongs to the SecE/SEC61-gamma family.


ensembl_gene_id: YDR087C
symbol: RRP1
gene_biotype: protein_coding
description:
  Ribosomal RNA-processing protein 1; Essential evolutionarily conserved nucleolar protein; necessary for biogenesis of 60S ribosomal subunits and for processing of pre-rRNAs to mature rRNA; associated with several distinct 66S pre-ribosomal particles; Belongs to the RRP1 family.


ensembl_gene_id: YDR088C
symbol: SLU7
gene_biotype: protein_coding
description:
  Pre-mRNA-splicing factor SLU7; RNA splicing factor; required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain; Belongs to the SLU7 family.


ensembl_gene_id: YDR089W
symbol: VTC5
gene_biotype: protein_coding
description:
  Uncharacterized protein YDR089W; Novel subunit of the vacuolar transporter chaperone complex; vacuolar transmembrane protein that regulates biosynthesis of polyphosphate; deletion reduces and overexpression increases polyP accumulation; SPX domain (Syg1, Pho81, Xpr1)-containing protein involved in phosphate homeostasis; relocalizes from vacuole to cytoplasm upon DNA replication stress.


ensembl_gene_id: YDR091C
symbol: RLI1
gene_biotype: protein_coding
description:
  Translation initiation factor RLI1; Essential Fe-S protein; required for ribosome biogenesis, translation initiation/termination; facilitates binding of multifactor complex (MFC) of initiation factors to small ribosomal subunit; Dom34-Hbs1 complex and Rli1p work in dissociating inactive ribosomes, thereby facilitating translation restart; forms complex with Lto1p and Yae1p; dependency on ROS-labile FeS clusters, activity in nuclear ribosomal-subunit export impaired by mild oxidative stress.


ensembl_gene_id: YDR092W
symbol: UBC13
gene_biotype: protein_coding
description:
  E2 ubiquitin-conjugating enzyme; involved in the error-free DNA postreplication repair pathway; interacts with Mms2p to assemble ubiquitin chains at the Ub Lys-63 residue; DNA damage triggers redistribution from the cytoplasm to the nucleus.


ensembl_gene_id: YDR093W
symbol: DNF2
gene_biotype: protein_coding
description:
  Phospholipid-transporting ATPase DNF2; Aminophospholipid translocase (flippase); type 4 P-type ATPase; involved in phospholipid translocation, contributing to endocytosis, protein transport, and cellular polarization; localizes primarily to the plasma membrane; localizes to the shmoo tip where it has a redundant role in the cellular response to mating pheromone; DNF2 has a paralog, DNF1, that arose from the whole genome duplication.


ensembl_gene_id: YDR094W
symbol: YDR094W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YDR094W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2/YDR093W.


ensembl_gene_id: YDR095C
symbol: YDR095C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YDR095C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YDR096W
symbol: GIS1
gene_biotype: protein_coding
description:
  Transcriptional activator/repressor GIS1; Histone demethylase and transcription factor; regulates genes during nutrient limitation; activity modulated by proteasome-mediated proteolysis; has JmjC and JmjN domain in N-terminus that interact, promoting stability and proper transcriptional activity; contains two transactivating domains downstream of Jmj domains and a C-terminal DNA binding domain; relocalizes to the cytosol in response to hypoxia; GIS1 has a paralog, RPH1, that arose from the whole genome duplication.


