# geneInfo

ensembl_gene_id: YGL196W
symbol: DSD1
gene_biotype: protein_coding
description:
  D-serine dehydratase (aka D-serine ammonia-lyase); converts D-serine to pyruvate and ammonia by a reaction dependent on pyridoxal 5'-phosphate and zinc; may play a role in D-serine detoxification; L-serine is not a substrate.


ensembl_gene_id: YGL197W
symbol: MDS3
gene_biotype: protein_coding
description:
  Putative component of the TOR regulatory pathway; negative regulator of early meiotic gene expression; required, with Pmd1p, for growth under alkaline conditions; has an N-terminal kelch-like domain; MDS3 has a paralog, PMD1, that arose from the whole genome duplication.


ensembl_gene_id: YGL198W
symbol: YIP4
gene_biotype: protein_coding
description:
  Protein that interacts with Rab GTPases; localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport; Belongs to the YIP1 family.


ensembl_gene_id: YGL199C
symbol: YGL199C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YGL199C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YIP4/YGL198W.


ensembl_gene_id: YGL200C
symbol: EMP24
gene_biotype: protein_coding
description:
  Endosomal protein P24B; Component of the p24 complex; role in misfolded protein quality control; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles.


ensembl_gene_id: YGL201C
symbol: MCM6
gene_biotype: protein_coding
description:
  DNA replication licensing factor MCM6; Protein involved in DNA replication; component of the Mcm2-7 hexameric helicase complex that binds chromatin as a part of the pre-replicative complex; forms a subcomplex with Mcm4p and Mcm7p.


ensembl_gene_id: YGL202W
symbol: ARO8
gene_biotype: protein_coding
description:
  Aromatic/aminoadipate aminotransferase 1; Aromatic aminotransferase I; expression is regulated by general control of amino acid biosynthesis.


ensembl_gene_id: YGL203C
symbol: KEX1
gene_biotype: protein_coding
description:
  Pheromone-processing carboxypeptidase KEX1; Cell death protease essential for hypochlorite-induced apoptosis; involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins.


ensembl_gene_id: YGL204C
symbol: YGL204C
gene_biotype: protein_coding
description:
  Uncharacterized protein YGL204C; Protein of unknown function; mRNA identified as translated by ribosome profiling data; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum.


ensembl_gene_id: YGL205W
symbol: POX1
gene_biotype: protein_coding
description:
  Fatty-acyl coenzyme A oxidase; involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix.


ensembl_gene_id: YGL206C
symbol: CHC1
gene_biotype: protein_coding
description:
  Clathrin heavy chain; subunit of the major coat protein involved in intracellular protein transport and endocytosis; the clathrin triskelion is a trimeric molecule composed of three heavy chains that radiate from a vertex and three light chains which bind noncovalently near the vertex of the triskelion; the light chain (CLC1) is thought to regulate function.


ensembl_gene_id: YGL207W
symbol: SPT16
gene_biotype: protein_coding
description:
  Subunit of the heterodimeric FACT complex (Spt16p-Pob3p); FACT associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases; specifically required for diauxic shift-induced H2B deposition onto rDNA genes; mutations cause reduced nucleosome occupancy over highly transcribed regions; coregulates transcription with Mot1p through preinitiation complex assembly and nucleosome organization.


ensembl_gene_id: YGL208W
symbol: SIP2
gene_biotype: protein_coding
description:
  One of three beta subunits of the Snf1 kinase complex; involved in the response to glucose starvation; null mutants exhibit accelerated aging; N-myristoylprotein localized to the cytoplasm and the plasma membrane; SIP2 has a paralog, GAL83, that arose from the whole genome duplication.


ensembl_gene_id: YGL209W
symbol: MIG2
gene_biotype: protein_coding
description:
  Regulatory protein MIG2; Zinc finger transcriptional repressor; cooperates with Mig1p in glucose-induced gene repression; under low glucose conditions relocalizes to mitochondrion, where it interacts with Ups1p, antagonizes mitochondrial fission factor Dnm1p, indicative of a role in mitochondrial fusion or regulating morphology; regulates filamentous growth in response to glucose depletion; activated in stochastic pulses of nuclear localization in response to low glucose.


ensembl_gene_id: YGL210W
symbol: YPT32
gene_biotype: protein_coding
description:
  GTP-binding protein YPT32/YPT11; Rab family GTPase involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; protein abundance increases in response to DNA replication stress; YPT32 has a paralog, YPT31, that arose from the whole genome duplication.


ensembl_gene_id: YGL211W
symbol: NCS6
gene_biotype: protein_coding
description:
  Cytoplasmic tRNA 2-thiolation protein 1; Protein required for uridine thiolation of Gln, Lys, and Glu tRNAs; required for the thiolation of uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae.


ensembl_gene_id: YGL212W
symbol: VAM7
gene_biotype: protein_coding
description:
  Vacuolar SNARE protein; functions with Vam3p in vacuolar protein trafficking; has an N-terminal PX domain (phosphoinositide-binding module) that binds PtdIns-3-P and mediates membrane binding; SNAP-25 homolog; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YGL213C
symbol: SKI8
gene_biotype: protein_coding
description:
  Antiviral protein SKI8; Ski complex component and WD-repeat protein; mediates 3'-5' RNA degradation by the cytoplasmic exosome; also required for meiotic double-strand break recombination; null mutants have superkiller phenotype.


ensembl_gene_id: YGL214W
symbol: YGL214W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YGL214W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion mutation phenotype is likely due to the overlapping verified ORF SKI8/YGL213C.


ensembl_gene_id: YGL215W
symbol: CLG1
gene_biotype: protein_coding
description:
  PHO85 cyclin CLG1; Cyclin-like protein that interacts with Pho85p; has sequence similarity to G1 cyclins PCL1 and PCL2.


ensembl_gene_id: YGL216W
symbol: KIP3
gene_biotype: protein_coding
description:
  Kinesin-like protein KIP3; Kinesin-related antiparallel sliding motor protein; involved in mitotic spindle positioning; sliding activity promotes bipolar spindle assembly and maintenance of genome stability; inhibits spindle elongation, destabilizing late anaphase spindle microtubules that polymerize beyond the midzone; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily.


ensembl_gene_id: YGL217C
symbol: YGL217C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YGL217C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF KIP3/YGL216W.


ensembl_gene_id: YGL218W
symbol: YGL218W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YGL218W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; 93% of ORF overlaps the verified gene MDM34; deletion in cyr1 mutant results in loss of stress resistance.


ensembl_gene_id: YGL219C
symbol: MDM34
gene_biotype: protein_coding
description:
  Mitochondrial distribution and morphology protein 34; Mitochondrial component of the ERMES complex; links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth; required for mitophagy; ERMES complex is often co-localized with peroxisomes and with concentrated areas of pyruvate dehydrogenase.


ensembl_gene_id: YGL220W
symbol: BOL2
gene_biotype: protein_coding
description:
  BolA-like protein 2; Cytosolic protein involved in repression of iron regulon transcription; forms an iron-independent complex with Fra1p, Grx3p, and Grx4p; null mutant fails to repress the iron regulon and is sensitive to nickel; sequence similarity to human BOLA family member, BOLA2; Belongs to the BolA/IbaG family.


ensembl_gene_id: YGL221C
symbol: NIF3
gene_biotype: protein_coding
description:
  NGG1-interacting factor 3; Protein of unknown function; similar to Listeria monocytogenes major sigma factor (rpoD gene product); the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies.


ensembl_gene_id: YGL222C
symbol: EDC1
gene_biotype: protein_coding
description:
  Enhancer of mRNA-decapping protein 1; RNA-binding protein that activates mRNA decapping directly; binds to mRNA substrate and enhances activity of decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress; EDC1 has a paralog, EDC2, that arose from the whole genome duplication.


ensembl_gene_id: YGL224C
symbol: SDT1
gene_biotype: protein_coding
description:
  Suppressor of disruption of TFIIS; Pyrimidine nucleotidase; responsible for production of nicotinamide riboside and nicotinic acid riboside; overexpression suppresses the 6-AU sensitivity of transcription elongation factor S-II, as well as resistance to other pyrimidine derivatives; SDT1 has a paralog, PHM8, that arose from the whole genome duplication.


ensembl_gene_id: YGL225W
symbol: VRG4
gene_biotype: protein_coding
description:
  Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi; VRG4 has a paralog, HVG1, that arose from the whole genome duplication; Belongs to the TPT transporter family. SLC35D subfamily.


ensembl_gene_id: YGL226C-A
symbol: OST5
gene_biotype: protein_coding
description:
  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST5; Zeta subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes asparagine-linked glycosylation of newly synthesized proteins.


ensembl_gene_id: YGL226W
symbol: MTC3
gene_biotype: protein_coding
description:
  Maintenance of telomere capping protein 3, mitochondrial; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; mtc3 is synthetically sick with cdc13-1.


ensembl_gene_id: YGL227W
symbol: VID30
gene_biotype: protein_coding
description:
  Vacuolar import and degradation protein 30; Central component of GID Complex, involved in FBPase degradation; interacts strongly with Gid8p to serve as a scaffold for other GID Complex subunits; contains SPRY domain and 3 domains that are also found in Gid8p - LisH, CTLH, and CRA; required for association of Vid vesicles and actin patches in vacuole import and degradation pathway; shifts the balance of nitrogen metabolism toward glutamate production; localizes to the nucleus and the cytoplasm.


ensembl_gene_id: YGL228W
symbol: SHE10
gene_biotype: protein_coding
description:
  Protein involved in outer spore wall assembly; likely involved directly in dityrosine layer assembly; putative GPI-anchored protein; overexpression causes growth arrest;; SWAT-GFP, seamless-GFP and mCherry fusion proteins localize to the endoplasmic reticulum; SHE10 has a paralog, OSW7/YFR039C, that arose from the whole genome duplication; paralogs are redundant for spore wall dityrosine assembly.


ensembl_gene_id: YGL229C
symbol: SAP4
gene_biotype: protein_coding
description:
  SIT4-associating protein SAP4; Protein required for function of the Sit4p protein phosphatase; member of a family of similar proteins that form complexes with Sit4p, including Sap155p, Sap185p, and Sap190p; SAP4 has a paralog, SAP155, that arose from the whole genome duplication.


ensembl_gene_id: YGL231C
symbol: EMC4
gene_biotype: protein_coding
description:
  Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm ZK616.6/EMC-4 and fly CG11137; mutation is functionally complemented by human EMC4.


ensembl_gene_id: YGL232W
symbol: TAN1
gene_biotype: protein_coding
description:
  Putative tRNA acetyltransferase; RNA-binding protein required for the formation of the modified nucleoside N(4)-acetylcytidine in serine and leucine tRNAs but not required for the same modification in 18S rRNA; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YGL233W
symbol: SEC15
gene_biotype: protein_coding
description:
  Essential 113 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis prior to SNARE-mediated fusion; interacts with and functions as a downstream effector of active, GTP-bound Sec4p, a Rab family GTPase.


ensembl_gene_id: YGL234W
symbol: ADE5,7
gene_biotype: protein_coding
description:
  Bifunctional purine biosynthetic protein ADE5,7; Enzyme of the 'de novo' purine nucleotide biosynthetic pathway; contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities; In the C-terminal section; belongs to the AIR synthase family.


ensembl_gene_id: YGL235W
symbol: YGL235W
gene_biotype: protein_coding
description:
  Uncharacterized protein YGL235W; Putative protein of unknown function; potential Cdc28p substrate; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2.


ensembl_gene_id: YGL236C
symbol: MTO1
gene_biotype: protein_coding
description:
  Mitochondrial protein; forms heterodimer complex with Mss1p that performs 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants; human homolog MTO1 can complement yeast null mutant; Belongs to the MnmG family.


ensembl_gene_id: YGL237C
symbol: HAP2
gene_biotype: protein_coding
description:
  Transcriptional activator HAP2; Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex; complex is heme-activated and glucose-repressed; complex is a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding; respiratory defect of the null mutant is functionally complemented by human NFYA.


ensembl_gene_id: YGL238W
symbol: CSE1
gene_biotype: protein_coding
description:
  Importin alpha re-exporter; Nuclear envelope protein that acts as a recycling factor; mediates the nuclear export of Srp1p (importin alpha) back to the cytoplasm after its import substrates have been released into the nucleoplasm, thereby allowing the participation of Srp1p in multiple rounds of nuclear import; required for accurate chromosome segregation; homolog of metazoan CAS and human CSE1L, overexpression of which is implicated in cancer progression.


ensembl_gene_id: YGL239C
symbol: YGL239C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YGL239C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified gene CSE1.


ensembl_gene_id: YGL240W
symbol: DOC1
gene_biotype: protein_coding
description:
  Anaphase-promoting complex subunit DOC1; Processivity factor; required for the ubiquitination activity of the anaphase promoting complex (APC), mediates the activity of the APC by contributing to substrate recognition; involved in cyclin proteolysis; contains a conserved DOC1 homology domain; Belongs to the APC10 family.


ensembl_gene_id: YGL241W
symbol: KAP114
gene_biotype: protein_coding
description:
  Importin subunit beta-5; Karyopherin, responsible for nuclear import of specific proteins; cargoes include Spt15p, Sua7p, histones H2A and H2B, and Nap1p; amino terminus shows similarity to those of other importins, particularly Cse1p; localization is primarily nuclear; function is regulated by sumoylation; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YGL242C
symbol: YGL242C
gene_biotype: protein_coding
description:
  Ankyrin repeat-containing protein YGL242C; Protein of unknown function; N-terminally propionylated in vivo; deletion mutant is viable.


ensembl_gene_id: YGL243W
symbol: TAD1
gene_biotype: protein_coding
description:
  tRNA-specific adenosine deaminase; deaminates adenosine-37 to inosine in tRNA-Ala; Belongs to the ADAT1 family.


ensembl_gene_id: YGL244W
symbol: RTF1
gene_biotype: protein_coding
description:
  RNA polymerase-associated protein RTF1; Subunit of RNAPII-associated chromatin remodeling Paf1 complex; regulates gene expression by directing cotranscriptional histone modification, influences transcription and chromatin structure through several independent functional domains; directly or indirectly regulates DNA-binding properties of Spt15p and relative activities of different TATA elements; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay.


ensembl_gene_id: YGL245W
symbol: GUS1
gene_biotype: protein_coding
description:
  Glutamate--tRNA ligase, cytoplasmic; Glutamyl-tRNA synthetase (GluRS); forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm; protein abundance increases in response to DNA replication stress; Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.


ensembl_gene_id: YGL246C
symbol: RAI1
gene_biotype: protein_coding
description:
  Nuclear protein with decapping endonuclease activity; targets mRNAs with unmethylated 7-methylguanosine cap structures and 5'-triphosphates; binds to and stabilizes the exoribonuclease Rat1p; required for pre-rRNA processing; relocalizes to the cytosol in response to hypoxia; homologous to human DOM3Z; Belongs to the DXO/Dom3Z family.


ensembl_gene_id: YGL247W
symbol: BRR6
gene_biotype: protein_coding
description:
  Nucleus export protein BRR6; Essential nuclear envelope integral membrane protein; interacts and functions with Apq12p and Brl1p in lipid homeostasis; mutants are defective in nuclear pore complex biogenesis, nuclear envelope morphology, mRNA nuclear export, and are sensitive to sterol biosynthesis inhibitors and membrane fluidizing agents; exhibits synthetic lethal genetic interactions with genes involved in lipid metabolism; homologous to Brl1p; Belongs to the BRL1/BRR6 family.


ensembl_gene_id: YGL248W
symbol: PDE1
gene_biotype: protein_coding
description:
  3',5'-cyclic-nucleotide phosphodiesterase 1; Low-affinity cyclic AMP phosphodiesterase; controls glucose and intracellular acidification-induced cAMP signaling, target of the cAMP-protein kinase A (PKA) pathway; glucose induces transcription and inhibits translation.


ensembl_gene_id: YGL249W
symbol: ZIP2
gene_biotype: protein_coding
description:
  Meiosis-specific protein; involved in normal synaptonemal complex formation and pairing between homologous chromosomes during meiosis; relocalizes from mitochondrion to cytoplasm upon DNA replication stress; Belongs to the ZIP2 family.


ensembl_gene_id: YGL250W
symbol: RMR1
gene_biotype: protein_coding
description:
  Protein required for meiotic recombination and gene conversion; null mutant displays reduced PIS1 expression and growth defects on non-fermentable carbon sources and minimal media; GFP-fusion protein localizes to both cytoplasm and nucleus; Belongs to the RMR1 family.


ensembl_gene_id: YGL251C
symbol: HFM1
gene_biotype: protein_coding
description:
  Meiosis specific DNA helicase; involved in the conversion of double-stranded breaks to later recombination intermediates and in crossover control; catalyzes the unwinding of Holliday junctions; has ssDNA and dsDNA stimulated ATPase activity.


ensembl_gene_id: YGL252C
symbol: RTG2
gene_biotype: protein_coding
description:
  Retrograde regulation protein 2; Sensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways; Rtg2p is inhibited by the phosphorylated form of Mks1p.


ensembl_gene_id: YGL253W
symbol: HXK2
gene_biotype: protein_coding
description:
  Hexokinase-2; Hexokinase isoenzyme 2; phosphorylates glucose in cytosol; predominant hexokinase during growth on glucose; represses expression of HXK1, GLK1, induces expression of its own gene; antiapoptotic; phosphorylation/dephosphorylation at Ser14 by kinase Snf1p, phosphatase Glc7p-Reg1p regulates nucleocytoplasmic shuttling of Hxk2p; functions downstream of Sit4p in control of cell cycle, mitochondrial function, oxidative stress resistance, chronological lifespan; has paralog HXK1; Belongs to the hexokinase family.


ensembl_gene_id: YGL254W
symbol: FZF1
gene_biotype: protein_coding
description:
  Zinc finger protein FZF1; Transcription factor involved in sulfite metabolism; sole identified regulatory target is SSU1; overexpression suppresses sulfite-sensitivity of many unrelated mutants due to hyperactivation of SSU1, contains five zinc fingers; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YGL255W
symbol: ZRT1
gene_biotype: protein_coding
description:
  Zinc-regulated transporter 1; High-affinity zinc transporter of the plasma membrane; responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor.


ensembl_gene_id: YGL256W
symbol: ADH4
gene_biotype: protein_coding
description:
  Alcohol dehydrogenase isoenzyme type IV; dimeric enzyme demonstrated to be zinc-dependent despite sequence similarity to iron-activated alcohol dehydrogenases; transcription is induced in response to zinc deficiency.


ensembl_gene_id: YGL257C
symbol: MNT2
gene_biotype: protein_coding
description:
  Alpha-1,3-mannosyltransferase MNT2; Mannosyltransferase; involved in adding the 4th and 5th mannose residues of O-linked glycans; Belongs to the MNN1/MNT family.


ensembl_gene_id: YGL258W
symbol: VEL1
gene_biotype: protein_coding
description:
  Protein of unknown function; highly induced in zinc-depleted conditions and has increased expression in NAP1 deletion mutants; VEL1 has a paralog, YOR387C, that arose from a single-locus duplication.


ensembl_gene_id: YGL259W
symbol: YPS5
gene_biotype: protein_coding
description:
  Yapsin-5; Protein with similarity to GPI-anchored aspartic proteases; such proteases are Yap1p and Yap3p; mCherry fusion protein localizes to the vacuole; Belongs to the peptidase A1 family.


ensembl_gene_id: YGL260W
symbol: YGL260W
gene_biotype: protein_coding
description:
  Putative protein of unknown function; transcription is significantly increased in a NAP1 deletion background; deletion mutant has increased accumulation of nickel and selenium; Belongs to the UPF0377 family.


ensembl_gene_id: YGL261C
symbol: PAU11
gene_biotype: protein_coding
description:
  Putative protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions; mRNA expression appears to be regulated by SUT1 and UPC2.


ensembl_gene_id: YGL262W
symbol: YGL262W
gene_biotype: protein_coding
description:
  Putative protein of unknown function; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein; YGL262W is not an essential gene; To yeast YER187w.


ensembl_gene_id: YGR001C
symbol: EFM5
gene_biotype: protein_coding
description:
  Protein-lysine N-methyltransferase EFM5; S-adenosylmethionine-dependent lysine methyltransferase; involved in the trimethylation of eEF1A (Tef1p/Tef2p) at lysine 79; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; required for replication of Brome mosaic virus in budding yeast; expresses a circular RNA; originally misclassified as a N-6-adenine specific DNA methyltransferase based on sequence similarity; both Efm5p and human ortholog N6AMT2 can methylate eEF1a from either species in vitro.


ensembl_gene_id: YGR002C
symbol: SWC4
gene_biotype: protein_coding
description:
  SWR1-complex protein 4; Component of the Swr1p complex that incorporates Htz1p into chromatin; component of the NuA4 histone acetyltransferase complex.


ensembl_gene_id: YGR003W
symbol: CUL3
gene_biotype: protein_coding
description:
  Cullin-3; Ubiquitin-protein ligase; forms a complex with Elc1p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; cullin family member with similarity to Cdc53p and human CUL3; Belongs to the cullin family.


ensembl_gene_id: YGR004W
symbol: PEX31
gene_biotype: protein_coding
description:
  Peroxisomal integral membrane protein; involved in negative regulation of peroxisome size; partially functionally redundant with Pex30p and Pex32p; probably acts at a step downstream of steps mediated by Pex28p and Pex29p; PEX31 has a paralog, PEX30, that arose from the whole genome duplication; Belongs to the PEX28-32 family. PEX30/31 subfamily.


ensembl_gene_id: YGR005C
symbol: TFG2
gene_biotype: protein_coding
description:
  TFIIF (Transcription Factor II) middle subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP30.


ensembl_gene_id: YGR006W
symbol: PRP18
gene_biotype: protein_coding
description:
  Pre-mRNA-splicing factor 18; Splicing factor and component of snRNP U5; factor involved in the positioning of the 3' splice site during the second catalytic step of splicing; interacts with Slu7p.


ensembl_gene_id: YGR007W
symbol: ECT1
gene_biotype: protein_coding
description:
  Ethanolamine-phosphate cytidylyltransferase; catalyzes the second step of phosphatidylethanolamine biosynthesis; involved in the maintenance of plasma membrane; similar to mammalian CTP: phosphocholine cytidylyl-transferases; inability of the null mutant to synthesize phosphatidylethanolamine and phosphatidylcholine from ethanolamine is functionally complemented by human PCYT2.


ensembl_gene_id: YGR008C
symbol: STF2
gene_biotype: protein_coding
description:
  ATPase-stabilizing factor 15 kDa protein; Protein involved in resistance to desiccation stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptosis; binds to F0 sector of mitochondrial F1F0 ATPase in vitro and may modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress; STF2 has a paralog, TMA10, that arose from the whole genome duplication.


ensembl_gene_id: YGR009C
symbol: SEC9
gene_biotype: protein_coding
description:
  t-SNARE protein required for secretory vesicle-plasma membrane fusion; similar to but not functionally redundant with Spo20p; interacts non-exocyst bound Sec6p; SNAP-25 homolog.


ensembl_gene_id: YGR010W
symbol: NMA2
gene_biotype: protein_coding
description:
  Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in de novo and salvage synthesis of NAD(+); homolog of human NMNAT; NMA2 has a paralog, NMA1, that arose from the whole genome duplication.


ensembl_gene_id: YGR011W
symbol: YGR011W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YGR011W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YGR013W
symbol: SNU71
gene_biotype: protein_coding
description:
  U1 small nuclear ribonucleoprotein component SNU71; Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart; Belongs to the SNU71 family.


ensembl_gene_id: YGR014W
symbol: MSB2
gene_biotype: protein_coding
description:
  Signaling mucin MSB2; Mucin family member involved in various signaling pathways; functions as osmosensor in the Sho1p-mediated HOG pathway; functions in Cdc42p- and MAP kinase-dependent filamentous growth signaling pathway; processed into secreted and cell-associated forms by aspartyl protease Yps1p; potential Cdc28p substrate; Belongs to the HKR1/MSB2 family.


ensembl_gene_id: YGR015C
symbol: YGR015C
gene_biotype: protein_coding
description:
  Ethanol acetyltransferase 1; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion.


ensembl_gene_id: YGR017W
symbol: YGR017W
gene_biotype: protein_coding
description:
  Uncharacterized protein YGR017W; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm.


ensembl_gene_id: YGR018C
symbol: YGR018C
gene_biotype: protein_coding
description:
  Uncharacterized protein YGR018C; Protein of unknown function; mRNA identified as translated by ribosome profiling data; partially overlaps the uncharacterized ORF YGR017W.


ensembl_gene_id: YGR019W
symbol: UGA1
gene_biotype: protein_coding
description:
  4-aminobutyrate aminotransferase; Gamma-aminobutyrate (GABA) transaminase; also known as 4-aminobutyrate aminotransferase; involved in the 4-aminobutyrate and glutamate degradation pathways; required for normal oxidative stress tolerance and nitrogen utilization; protein abundance increases in response to DNA replication stress; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.


ensembl_gene_id: YGR020C
symbol: VMA7
gene_biotype: protein_coding
description:
  Subunit F of the V1 peripheral membrane domain of V-ATPase; part of the electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane; the V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase) has eight subunits.


ensembl_gene_id: YGR021W
symbol: YGR021W
gene_biotype: protein_coding
description:
  Probable transcriptional regulatory protein HAH1; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Belongs to the TACO1 family.


ensembl_gene_id: YGR022C
symbol: YGR022C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YGR022C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W.


ensembl_gene_id: YGR023W
symbol: MTL1
gene_biotype: protein_coding
description:
  Protein MTL1; Putative plasma membrane sensor; involved in cell integrity signaling and stress response during glucose starvation and oxidative stress; has structural and functional similarity to Mid2p; MTL1 has a paralog, MID2, that arose from the whole genome duplication.


ensembl_gene_id: YGR024C
symbol: THG1
gene_biotype: protein_coding
description:
  tRNAHis guanylyltransferase; adds a guanosine residue to the 5' end of tRNAH is after transcription and RNase P cleavage; can also catalyze reverse (3'-5') polymerization with certain substrates in a template-dependent reaction; couples nuclear division and migration to cell budding and cytokinesis; essential enzyme conserved among eukaryotes.


ensembl_gene_id: YGR025W
symbol: YGR025W
gene_biotype: protein_coding
description:
  Uncharacterized protein YGR025W; Putative protein of unknown function; conserved across S. cerevisiae strains.


ensembl_gene_id: YGR026W
symbol: YGR026W
gene_biotype: protein_coding
description:
  Uncharacterized membrane protein YGR026W; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery.


ensembl_gene_id: YGR027C
symbol: RPS25A
gene_biotype: protein_coding
description:
  Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S25, no bacterial homolog; RPS25A has a paralog, RPS25B, that arose from the whole genome duplication.


ensembl_gene_id: YGR028W
symbol: MSP1
gene_biotype: protein_coding
description:
  Protein MSP1; Highly-conserved N-terminally anchored AAA-ATPase; distributed in the mitochondrial outer membrane and peroxisomes; involved in mitochondrial protein sorting; functions as an extraction engine in local organelle surveillance to remove and initiate degradation of mistargeted proteins, ensuring fidelity of organelle-specific localization of tail-anchored proteins; contains an N-terminal transmembrane domain and C-terminal cytoplasmic ATPase domain.


ensembl_gene_id: YGR029W
symbol: ERV1
gene_biotype: protein_coding
description:
  Flavin-linked sulfhydryl oxidase of the mitochondrial IMS; N-terminus is an intrinsically disordered domain that in the cytosol helps target Erv1p to mitochondria, and in the intermembrane space oxidizes Mia40p as part of a disulfide relay system that promotes intermembrane space retention of imported proteins; functional ortholog of human GFER (ALR); human GFER carrying N-terminal 21 amino acids of Erv1p functionally complements the lethality of the erv1 null mutation.


ensembl_gene_id: YGR030C
symbol: POP6
gene_biotype: protein_coding
description:
  Ribonucleases P/MRP protein subunit POP6; Subunit of RNase MRP, nuclear RNase P and telomerase; forms a soluble heterodimer with Pop7p that binds P3 domain of RNase MRP and RNase P RNAs; RNase MRP cleaves pre-rRNA, nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs, while telomerase replenishes telomeric DNA; relocalizes to the cytosol in response to hypoxia.


ensembl_gene_id: YGR031C-A
symbol: NAG1
gene_biotype: protein_coding
description:
  Protein involved in yeast cell wall biogenesis; localizes to the cell periphery; production of Nag1p is dependent upon the presence of Slt2p and Rlm1p; gene is nested within and antisense to IMO32.


ensembl_gene_id: YGR031W
symbol: IMO32
gene_biotype: protein_coding
description:
  Probable alcohol acetyltransferase; Conserved mitochondrial protein of unknown function; processed by both mitochondrial processing peptidase and mitochondrial octapeptidyl aminopeptidase; gene contains the nested antisense gene NAG1.


ensembl_gene_id: YGR032W
symbol: GSC2
gene_biotype: protein_coding
description:
  Catalytic subunit of 1,3-beta-glucan synthase; involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; GSC2 has a paralog, FKS1, that arose from the whole genome duplication; Belongs to the glycosyltransferase 48 family.


ensembl_gene_id: YGR033C
symbol: TIM21
gene_biotype: protein_coding
description:
  Mitochondrial import inner membrane translocase subunit TIM21; Nonessential component of the TIM23 complex; interacts with the Translocase of the Outer Mitochondrial membrane (TOM complex) and with respiratory enzymes; may regulate the Translocase of the Inner Mitochondrial membrane (TIM23 complex) activity.


ensembl_gene_id: YGR034W
symbol: RPL26B
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L26B; binds to 5.8S rRNA; non-essential even when paralog is also deleted; deletion has minimal affections on ribosome biosynthesis; homologous to mammalian ribosomal protein L26 and bacterial L24; RPL26B has a paralog, RPL26A, that arose from the whole genome duplication.


ensembl_gene_id: YGR035C
symbol: YGR035C
gene_biotype: protein_coding
description:
  Uncharacterized protein YGR035C; Putative protein of unknown function, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; YGR035C has a paralog, YLR346C, that arose from the whole genome duplication.


ensembl_gene_id: YGR036C
symbol: CAX4
gene_biotype: protein_coding
description:
  Dolichyldiphosphatase; Dolichyl pyrophosphate (Dol-P-P) phosphatase; has a luminally oriented active site in the ER; cleaves the anhydride linkage in Dol-P-P; required for Dol-P-P-linked oligosaccharide intermediate synthesis and protein N-glycosylation.


ensembl_gene_id: YGR037C
symbol: ACB1
gene_biotype: protein_coding
description:
  Acyl-CoA-binding protein; transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes; subject to starvation-induced, Grh1p-mediated unconventional secretion; protein abundance increases in response to DNA replication stress; Belongs to the ACBP family.


ensembl_gene_id: YGR038W
symbol: ORM1
gene_biotype: protein_coding
description:
  Protein that mediates sphingolipid homeostasis; evolutionarily conserved, required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control; ORM1 has a paralog, ORM2, that arose from the whole genome duplication.


ensembl_gene_id: YGR039W
symbol: YGR039W
gene_biotype: protein_coding
description:
  Uncharacterized protein YGR039W; Putative protein of unknown function; conserved among S. cerevisiae strains; YGR039W is not an essential gene.


ensembl_gene_id: YGR040W
symbol: KSS1
gene_biotype: protein_coding
description:
  Mitogen-activated protein kinase (MAPK); involved in signal transduction pathways that control filamentous growth and pheromone response; regulates septum assembly, and may directly phosphorylate Bni4p; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains.


ensembl_gene_id: YGR041W
symbol: BUD9
gene_biotype: protein_coding
description:
  Protein involved in bud-site selection; mutant has increased aneuploidy tolerance; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the distal pole; BUD9 has a paralog, BUD8, that arose from the whole genome duplication; To yeast BUD8.


ensembl_gene_id: YGR042W
symbol: MTE1
gene_biotype: protein_coding
description:
  Uncharacterized protein YGR042W; Protein of unknown function; involved in maintenance of proper telomere length; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; forms nuclear foci upon DNA replication stress.


ensembl_gene_id: YGR043C
symbol: NQM1
gene_biotype: protein_coding
description:
  Transaldolase of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift; NQM1 has a paralog, TAL1, that arose from the whole genome duplication.


ensembl_gene_id: YGR044C
symbol: RME1
gene_biotype: protein_coding
description:
  Zinc finger protein involved in control of meiosis; prevents meiosis by repressing IME1 expression and promotes mitosis by activating CLN2 expression; directly repressed by a1-alpha2 regulator; mediates cell type control of sporulation; relocalizes from nucleus to cytoplasm upon DNA replication stress.


ensembl_gene_id: YGR045C
symbol: YGR045C
gene_biotype: protein_coding
description:
  Uncharacterized protein YGR045C; Putative protein of unknown function; conserved across S. cerevisiae strains.


ensembl_gene_id: YGR046W
symbol: TAM41
gene_biotype: protein_coding
description:
  Mitochondrial phosphatidate cytidylyltransferase (CDP-DAG synthase); required for cardiolipin biosynthesis; viability of null mutant is strain-dependent; mRNA is targeted to the bud; mutant displays defect in mitochondrial protein import, likely due to altered membrane lipid composition; Belongs to the TAM41 family.


ensembl_gene_id: YGR047C
symbol: TFC4
gene_biotype: protein_coding
description:
  Subunit of RNA polymerase III transcription initiation factor complex; one of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA domain of TFIIIC that binds BoxA DNA promoter sites of tRNA and similar genes; has TPR motifs; human homolog is TFIIIC-102.


ensembl_gene_id: YGR048W
symbol: UFD1
gene_biotype: protein_coding
description:
  Ubiquitin fusion degradation protein 1; Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; polyubiquitin binding protein that assists in the dislocation of misfolded, ERAD substrates that are subsequently delivered to the proteasome for degradation; involved in regulated destruction of ER membrane proteins such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); involved in mobilizing membrane bound transcription factors by regulated Ub/proteasome-dependent processing (RUP).


ensembl_gene_id: YGR049W
symbol: SCM4
gene_biotype: protein_coding
description:
  Protein SCM4; Mitochondrial outer membrane protein of unknown function; predicted to have 4 transmembrane segments; import is mediated by Tom70p and Mim1p; interacts genetically with a cdc4 mutation; SCM4 has a paralog, ATG33, that arose from the whole genome duplication.


ensembl_gene_id: YGR050C
symbol: YGR050C
gene_biotype: protein_coding
description:
  Uncharacterized protein YGR050C; Protein of unknown function; mRNA identified as translated by ribosome profiling data.


ensembl_gene_id: YGR051C
symbol: YGR051C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YGR051C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; YGR051C is not an essential gene.


ensembl_gene_id: YGR052W
symbol: FMP48
gene_biotype: protein_coding
description:
  Probable serine/threonine-protein kinase FMP48; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.


ensembl_gene_id: YGR054W
symbol: YGR054W
gene_biotype: protein_coding
description:
  Eukaryotic initiation factor eIF2A; associates specifically with both 40S subunits and 80 S ribosomes, and interacts genetically with both eIF5b and eIF4E; homologous to mammalian eIF2A; Belongs to the WD repeat EIF2A family.


ensembl_gene_id: YGR055W
symbol: MUP1
gene_biotype: protein_coding
description:
  High affinity methionine permease; integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake; To yeast low affinity methionine permease (MUP3).


ensembl_gene_id: YGR056W
symbol: RSC1
gene_biotype: protein_coding
description:
  Chromatin structure-remodeling complex subunit RSC1; Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; contains two essential bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook; RSC1 has a paralog, RSC2, that arose from the whole genome duplication; Belongs to the RSC1 family.


ensembl_gene_id: YGR057C
symbol: LST7
gene_biotype: protein_coding
description:
  Protein LST7; Subunit of the Lst4p-Lst7p GTPase activating protein complex for Gtr2p; stimulates the GTPase activity of Rag family GTPase Gtr2p, within the context of the Gtr1p-Gtr2p heterodimer, after amino acid stimulation; required for activation of TORC1 in response to amino acid stimulation; recruited to the vacuolar membrane during amino acid starvation and released from the membrane by TORC1; required for the transport of amino acid permease Gap1p from the Golgi to the cell surface.


ensembl_gene_id: YGR058W
symbol: PEF1
gene_biotype: protein_coding
description:
  Peflin; Penta-EF-hand protein; required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly.


ensembl_gene_id: YGR059W
symbol: SPR3
gene_biotype: protein_coding
description:
  Sporulation-regulated protein 3; Sporulation-specific homolog of the CDC3/10/11/12 family of genes; septin protein involved in sporulation; regulated by ABFI; the yeast CDC3/10/11/12 family is a family of bud neck microfilament genes; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.


ensembl_gene_id: YGR060W
symbol: ERG25
gene_biotype: protein_coding
description:
  Methylsterol monooxygenase; C-4 methyl sterol oxidase; catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol; human MSMO1 functionally complements the growth defect caused by repression of ERG25 expression.


ensembl_gene_id: YGR061C
symbol: ADE6
gene_biotype: protein_coding
description:
  Phosphoribosylformylglycinamidine synthase; Formylglycinamidine-ribonucleotide (FGAM)-synthetase; catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway.


ensembl_gene_id: YGR062C
symbol: COX18
gene_biotype: protein_coding
description:
  Cytochrome c oxidase assembly protein COX18, mitochondrial; Protein required for membrane insertion of C-terminus of Cox2p; mitochondrial integral inner membrane protein; interacts genetically and physically with Mss2p and Pnt1p; similar to S. cerevisiae Oxa1, N. crassa Oxa2p, and E. coli YidC; respiratory defect of the null mutant is functionally complemented by human COX18 carrying the N-terminal 54 amino acids of S. cerevisiae Cox18p; Belongs to the OXA1/ALB3/YidC family.


ensembl_gene_id: YGR063C
symbol: SPT4
gene_biotype: protein_coding
description:
  Spt4p/5p (DSIF) transcription elongation factor complex subunit; the Spt4/5 complex binds to ssRNA in a sequence-specific manner, and along with RNAP I and II has multiple roles regulating transcriptional elongation, RNA processing, quality control, and transcription-coupled repair; localizes to kinetochores and heterochromatin, influencing chromosomal dynamics and silencing; required for transcription through long trinucleotide repeats in ORFs and non-protein coding regions.


ensembl_gene_id: YGR064W
symbol: YGR064W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YGR064W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SPT4/YGR063C.


ensembl_gene_id: YGR065C
symbol: VHT1
gene_biotype: protein_coding
description:
  Vitamin H transporter; High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin; Belongs to the major facilitator superfamily. Allantoate permease family.


ensembl_gene_id: YGR068C
symbol: ART5
gene_biotype: protein_coding
description:
  Arrestin-related trafficking adapter 5; Protein proposed to regulate endocytosis of plasma membrane proteins; regulates by recruiting the ubiquitin ligase Rsp5p to its target in the plasma membrane; SWAT-GFP and mCherry fusion proteins localize to the cytosol.


ensembl_gene_id: YGR068W-A
symbol: YGR068W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YGR068W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps with the uncharacterized ORF YGR068C.


ensembl_gene_id: YGR069W
symbol: YGR069W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YGR069W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YGR070W
symbol: ROM1
gene_biotype: protein_coding
description:
  Guanine nucleotide exchange factor (GEF) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP; ROM1 has a paralog, ROM2, that arose from the whole genome duplication.


ensembl_gene_id: YGR071C
symbol: ENV11
gene_biotype: protein_coding
description:
  Late endosome and vacuole interface protein 11; Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and fragmented vacuoles; deletion mutant has increased glycogen accumulation and displays elongated buds; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; ENV11 has a paralog, VID22, that arose from the whole genome duplication.


ensembl_gene_id: YGR072W
symbol: UPF3
gene_biotype: protein_coding
description:
  Component of the nonsense-mediated mRNA decay (NMD) pathway; along with Nam7p and Nmd2p; involved in decay of mRNA containing nonsense codons; involved in telomere maintenance; Belongs to the RENT3 family.


ensembl_gene_id: YGR073C
symbol: YGR073C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YGR073C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; extensively overlaps essential SMD1 gene encoding a U6 snRNP protein.


ensembl_gene_id: YGR074W
symbol: SMD1
gene_biotype: protein_coding
description:
  Small nuclear ribonucleoprotein Sm D1; Core Sm protein Sm D1; part of heteroheptameric complex (with Smb1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; relocalizes to the cytosol in response to hypoxia; homolog of human Sm D1; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YGR075C
symbol: PRP38
gene_biotype: protein_coding
description:
  Pre-mRNA-splicing factor 38; Unique component of the U4/U6.U5 tri-snRNP particle; tri-snRNP is required for conformational changes which result in the catalytic activation of the spliceosome; dispensable for spliceosome assembly; Belongs to the PRP38 family.


ensembl_gene_id: YGR076C
symbol: MRPL25
gene_biotype: protein_coding
description:
  Mitochondrial ribosomal protein of the large subunit; mutation confers increased replicative lifespan.


ensembl_gene_id: YGR077C
symbol: PEX8
gene_biotype: protein_coding
description:
  Peroxisomal biogenesis factor 8; Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p.


ensembl_gene_id: YGR078C
symbol: PAC10
gene_biotype: protein_coding
description:
  Prefoldin subunit 3; Part of the heteromeric co-chaperone GimC/prefoldin complex; complex promotes efficient protein folding; Belongs to the prefoldin subunit alpha family.


ensembl_gene_id: YGR080W
symbol: TWF1
gene_biotype: protein_coding
description:
  Twinfilin-1; Twinfilin; highly conserved actin monomer-sequestering protein involved in regulation of the cortical actin cytoskeleton; coordinates actin filament severing and monomer sequestering at sites of rapid actin turnover; composed of two cofilin-like regions, stimulates actin depolymerization as does the mouse homolog, mTwf1.


ensembl_gene_id: YGR081C
symbol: SLX9
gene_biotype: protein_coding
description:
  Ribosome biogenesis protein SLX9; Protein required for pre-rRNA processing; associated with the 90S pre-ribosome and 43S small ribosomal subunit precursor; interacts with U3 snoRNA; deletion mutant has synthetic fitness defect with an sgs1 deletion mutant; Belongs to the SLX9 family.


ensembl_gene_id: YGR082W
symbol: TOM20
gene_biotype: protein_coding
description:
  Mitochondrial import receptor subunit TOM20; Component of the TOM (translocase of outer membrane) complex; responsible for recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins.


ensembl_gene_id: YGR083C
symbol: GCD2
gene_biotype: protein_coding
description:
  Delta subunit of the translation initiation factor eIF2B; the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression; Belongs to the eIF-2B alpha/beta/delta subunits family.


ensembl_gene_id: YGR085C
symbol: RPL11B
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L11B; expressed at half the level of Rpl11Ap; involved in ribosomal assembly; depletion causes degradation of 60S proteins and RNA; homologous to mammalian ribosomal protein L11 and bacterial L5; RPL11B has a paralog, RPL11A, that arose from the whole genome duplication.


ensembl_gene_id: YGR086C
symbol: PIL1
gene_biotype: protein_coding
description:
  Sphingolipid long chain base-responsive protein PIL1; Eisosome core component; eisosomes are large immobile cell cortex structures associated with endocytosis; detected in phosphorylated state in mitochondria; phosphorylated on Thr233 upon Pkc1p hyperactivation in a Slt2p MAPK-dependent fashion; null mutant shows activation of Pkc1p/Ypk1p stress resistance pathways; member of BAR domain family; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress.


ensembl_gene_id: YGR087C
symbol: PDC6
gene_biotype: protein_coding
description:
  Minor isoform of pyruvate decarboxylase; decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation; Belongs to the TPP enzyme family.


ensembl_gene_id: YGR089W
symbol: NNF2
gene_biotype: protein_coding
description:
  Protein that exhibits physical and genetic interactions with Rpb8p; Rpb8p is a subunit of RNA polymerases I, II, and III; computational analysis of large-scale protein-protein interaction data suggests a role in chromosome segregation.


ensembl_gene_id: YGR090W
symbol: UTP22
gene_biotype: protein_coding
description:
  U3 small nucleolar RNA-associated protein 22; Component of the small-subunit processome; required for nuclear export of tRNAs; may facilitate binding of Utp8p to aminoacylated tRNAs and their delivery to Los1p for export; conserved from yeast to mammals.


ensembl_gene_id: YGR091W
symbol: PRP31
gene_biotype: protein_coding
description:
  Pre-mRNA-processing factor 31; Splicing factor; component of the U4/U6-U5 snRNP complex; Belongs to the PRP31 family.


ensembl_gene_id: YGR092W
symbol: DBF2
gene_biotype: protein_coding
description:
  Cell cycle protein kinase DBF2; Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis; localization is cell cycle regulated; activated by Cdc15p during the exit from mitosis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs; phosphorylates Chs2p to regulate primary septum formation and Hof1p to regulate cytokinesis; DBF2 has a paralog, DBF20, that arose from the whole genome duplication.


ensembl_gene_id: YGR093W
symbol: DRN1
gene_biotype: protein_coding
description:
  CWF19-like protein DRN1; Splicing factor that modulates turnover of branched RNAs by Dbr1p; interacts with spliceosomal components and branched RNA splicing products; enhances Dbr1p debranching in vitro; conserved protein with domain organization identical from yeast to human; N-terminal homology to Dbr1p N-terminus, but Dbr1p catalytic residues not conserved; relocalizes to the cytosol in response to hypoxia.


ensembl_gene_id: YGR094W
symbol: VAS1
gene_biotype: protein_coding
description:
  Valine--tRNA ligase, mitochondrial; Mitochondrial and cytoplasmic valyl-tRNA synthetase; human homolog VARS2 implicated in mitochondrial diseases, can partially complement yeast null mutant; Belongs to the class-I aminoacyl-tRNA synthetase family.


ensembl_gene_id: YGR095C
symbol: RRP46
gene_biotype: protein_coding
description:
  Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp46p (EXOSC5).


ensembl_gene_id: YGR096W
symbol: TPC1
gene_biotype: protein_coding
description:
  Mitochondrial thiamine pyrophosphate carrier 1; Mitochondrial membrane transporter; mediates uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria; expression appears to be regulated by carbon source; member of the mitochondrial carrier family.


ensembl_gene_id: YGR097W
symbol: ASK10
gene_biotype: protein_coding
description:
  Activator of SKN7 protein 10; Regulator of the Fps1p glycerol channel; under nonstress conditions, binds to Fps1p to positively regulate glycerol transport; under osmotic stress, multiple phosphorylation by Hog1p causes Ask10p to dissociate from Fps1p; forms homodimers and heterodimerizes with paralog Rgc1p; phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; associates with RNA polymerase II holoenzyme.


ensembl_gene_id: YGR098C
symbol: ESP1
gene_biotype: protein_coding
description:
  Separin; Separase, a caspase-like cysteine protease; promotes sister chromatid separation by mediating dissociation of the cohesin Scc1p from chromatin; inhibits protein phosphatase 2A-Cdc55p to promote mitotic exit; inhibited by Pds1p; relative distribution to the nucleus increases upon DNA replication stress.


ensembl_gene_id: YGR099W
symbol: TEL2
gene_biotype: protein_coding
description:
  Telomere length regulation protein TEL2; Subunit of the ASTRA complex, involved in chromatin remodeling; subunit of the telomere cap complex DNA-binding protein specific to single-stranded yeast telomeric DNA repeats, required for telomere length regulation and telomere position effect; involved in the stability or biogenesis of PIKKs such as TORC1; Belongs to the TEL2 family.


ensembl_gene_id: YGR100W
symbol: MDR1
gene_biotype: protein_coding
description:
  Cytoplasmic GTPase-activating protein; activates Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function.


ensembl_gene_id: YGR101W
symbol: PCP1
gene_biotype: protein_coding
description:
  Rhomboid protein 1, mitochondrial; Mitochondrial serine protease; required for the processing of various mitochondrial proteins and maintenance of mitochondrial DNA and morphology; belongs to the rhomboid-GlpG superfamily of intramembrane peptidases.


ensembl_gene_id: YGR102C
symbol: GTF1
gene_biotype: protein_coding
description:
  Glutamyl-tRNA(Gln) amidotransferase subunit F, mitochondrial; Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria.


ensembl_gene_id: YGR103W
symbol: NOP7
gene_biotype: protein_coding
description:
  Pescadillo homolog; Component of several different pre-ribosomal particles; forms a complex with Ytm1p and Erb1p that is required for maturation of the large ribosomal subunit; required for exit from G<sub>0</sub> and the initiation of cell proliferation.


ensembl_gene_id: YGR104C
symbol: SRB5
gene_biotype: protein_coding
description:
  Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; required for proper termination of transcription for some genes; involved in telomere maintenance.


ensembl_gene_id: YGR105W
symbol: VMA21
gene_biotype: protein_coding
description:
  Integral membrane protein required for V-ATPase function; not an actual component of the vacuolar H+-ATPase (V-ATPase) complex; diverged ortholog of human XMEA (X-linked Myopathy with Excessive Autophagy); functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER).


ensembl_gene_id: YGR106C
symbol: VOA1
gene_biotype: protein_coding
description:
  ER protein that functions in assembly of the V0 sector of V-ATPase; functions with other assembly factors; null mutation enhances the vacuolar ATPase (V-ATPase) deficiency of a vma21 mutant impaired in endoplasmic reticulum (ER) retrieval; Belongs to the VOA1 family.


ensembl_gene_id: YGR107W
symbol: YGR107W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YGR107W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YGR108W
symbol: CLB1
gene_biotype: protein_coding
description:
  G2/mitotic-specific cyclin-1; B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome; CLB1 has a paralog, CLB2, that arose from the whole genome duplication.


ensembl_gene_id: YGR109C
symbol: CLB6
gene_biotype: protein_coding
description:
  S-phase entry cyclin-6; B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1; CLB6 has a paralog, CLB5, that arose from the whole genome duplication.


ensembl_gene_id: YGR110W
symbol: CLD1
gene_biotype: protein_coding
description:
  Mitochondrial cardiolipin-specific phospholipase; functions upstream of Taz1p to generate monolyso-cardiolipin; transcription increases upon genotoxic stress; involved in restricting Ty1 transposition; has homology to mammalian CGI-58; Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.


ensembl_gene_id: YGR111W
symbol: YGR111W
gene_biotype: protein_coding
description:
  Uncharacterized protein YGR111W; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus.


ensembl_gene_id: YGR112W
symbol: SHY1
gene_biotype: protein_coding
description:
  Cytochrome oxidase assembly protein SHY1; Mitochondrial inner membrane protein required for complex IV assembly; associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; similar to human SURF1 involved in Leigh Syndrome; complex IV is also known as cytochrome c oxidase.


ensembl_gene_id: YGR113W
symbol: DAM1
gene_biotype: protein_coding
description:
  Essential subunit of the Dam1 complex (aka DASH complex); cooperates with Duo1p to connect the DASH complex with the microtubules (MT); couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; Ipl1p target for regulating kinetochore-MT attachments.


ensembl_gene_id: YGR114C
symbol: YGR114C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YGR114C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; open reading frame overlaps 5' end of the essential gene SPT6.


ensembl_gene_id: YGR115C
symbol: YGR115C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YGR115C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified and essential ORF SPT6/YGR115C.


ensembl_gene_id: YGR116W
symbol: SPT6
gene_biotype: protein_coding
description:
  Transcription elongation factor SPT6; Nucleosome remodeling protein; functions in various aspects of transcription, chromatin maintenance, and RNA processing; required for the maintenance of chromatin structure during transcription in order to inhibit transcription from promoters within the coding region; required for H3K36 trimethylation but not dimethylation by Set2p.


ensembl_gene_id: YGR117C
symbol: YGR117C
gene_biotype: protein_coding
description:
  Uncharacterized protein YGR117C; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm.


ensembl_gene_id: YGR118W
symbol: RPS23A
gene_biotype: protein_coding
description:
  Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit; required for translational accuracy; homologous to mammalian ribosomal protein S23 and bacterial S12; RPS23A has a paralog, RPS23B, that arose from the whole genome duplication; deletion of both RPS23A and RPS23B is lethal.


ensembl_gene_id: YGR119C
symbol: NUP57
gene_biotype: protein_coding
description:
  FG-nucleoporin component of central core of the nuclear pore complex; contributes directly to nucleocytoplasmic transport and maintenance of the nuclear pore complex (NPC) permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup49p).


ensembl_gene_id: YGR120C
symbol: COG2
gene_biotype: protein_coding
description:
  Essential component of the conserved oligomeric Golgi complex; a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments; the components of the Golgi complex are Gog1p through Cog8p.


ensembl_gene_id: YGR121C
symbol: MEP1
gene_biotype: protein_coding
description:
  Ammonium transporter MEP1; Ammonium permease; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation; human homolog RHCG complements yeast null mutant; mutations in human homolog RHCG implicated in metabolic acidosis; MEP1 has a paralog, MEP3, that arose from the whole genome duplication.


ensembl_gene_id: YGR122C-A
symbol: YGR122C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YGR122C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; similar to YLR334C and YOL106W.


ensembl_gene_id: YGR122W
symbol: YGR122W
gene_biotype: protein_coding
description:
  Uncharacterized protein YGR122W; Protein that may be involved in pH regulation; probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex; null mutant does not properly process Rim101p and has decreased resistance to rapamycin; GFP-fusion protein is cytoplasmic; relative distribution to cytoplasm increases upon DNA replication stress.


ensembl_gene_id: YGR123C
symbol: PPT1
gene_biotype: protein_coding
description:
  Protein serine/threonine phosphatase; regulates Hsp90 chaperone by affecting its ATPase and cochaperone binding activities; has similarity to human phosphatase PP5; present in both the nucleus and cytoplasm; expressed during logarithmic growth; Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.


ensembl_gene_id: YGR124W
symbol: ASN2
gene_biotype: protein_coding
description:
  Asparagine synthetase; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway; ASN2 has a paralog, ASN1, that arose from the whole genome duplication.


ensembl_gene_id: YGR125W
symbol: YGR125W
gene_biotype: protein_coding
description:
  Uncharacterized vacuolar membrane protein YGR125W; Putative protein of unknown function; deletion mutant has decreased rapamycin resistance but normal wormannin resistance; green fluorescent protein (GFP)-fusion protein localizes to the vacuole.


ensembl_gene_id: YGR126W
symbol: YGR126W
gene_biotype: protein_coding
description:
  Uncharacterized protein YGR126W; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS.


ensembl_gene_id: YGR127W
symbol: YGR127W
gene_biotype: protein_coding
description:
  Uncharacterized protein YGR127W; Putative protein of unknown function; expression is regulated by Msn2p/Msn4p, indicating a possible role in stress response.


ensembl_gene_id: YGR128C
symbol: UTP8
gene_biotype: protein_coding
description:
  U3 small nucleolar RNA-associated protein 8; Nucleolar protein required for export of tRNAs from the nucleus; also copurifies with the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA.


ensembl_gene_id: YGR129W
symbol: SYF2
gene_biotype: protein_coding
description:
  Pre-mRNA-splicing factor SYF2; Member of the NineTeen Complex (NTC); NTC contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; relocalizes to the cytosol in response to hypoxia; isy1 syf2 cells have defective spindles activiating cell cycle arrest.


ensembl_gene_id: YGR130C
symbol: YGR130C
gene_biotype: protein_coding
description:
  Uncharacterized protein YGR130C; Component of the eisosome with unknown function; GFP-fusion protein localizes to the cytoplasm; specifically phosphorylated in vitro by mammalian diphosphoinositol pentakisphosphate (IP7).


ensembl_gene_id: YGR131W
symbol: FHN1
gene_biotype: protein_coding
description:
  Non-classical export protein 2 homolog 1; Protein of unknown function; induced by ketoconazole; promoter region contains sterol regulatory element motif, which has been identified as a Upc2p-binding site; overexpression complements function of Nce102p in NCE102 deletion strain; FHN1 has a paralog, NCE102, that arose from the whole genome duplication.


ensembl_gene_id: YGR132C
symbol: PHB1
gene_biotype: protein_coding
description:
  Prohibitin-1; Subunit of the prohibitin complex (Phb1p-Phb2p); prohibitin is a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation; prohibitin deficiency induces a mitochondrial unfolded protein response (mtUPR).


ensembl_gene_id: YGR133W
symbol: PEX4
gene_biotype: protein_coding
description:
  Ubiquitin-conjugating enzyme E2-21 kDa; Peroxisomal ubiquitin conjugating enzyme; required for peroxisomal matrix protein import and peroxisome biogenesis.


ensembl_gene_id: YGR134W
symbol: CAF130
gene_biotype: protein_coding
description:
  Protein CAF130; Subunit of the CCR4-NOT transcriptional regulatory complex; CCR4-NOT complex is evolutionarily-conserved and involved in controlling mRNA initiation, elongation, and degradation.


ensembl_gene_id: YGR135W
symbol: PRE9
gene_biotype: protein_coding
description:
  Alpha 3 subunit of the 20S proteasome; the only nonessential 20S subunit; may be replaced by the alpha 4 subunit (Pre6p) under stress conditions to create a more active proteasomal isoform; Belongs to the peptidase T1A family.


ensembl_gene_id: YGR136W
symbol: LSB1
gene_biotype: protein_coding
description:
  LAS seventeen-binding protein 1; Negative regulator of actin nucleation-promoting factor activity; interacts with Las17p, a homolog of human Wiskott-Aldrich Syndrome protein (WASP), via an N-terminal SH3 domain, and along with PIN3 cooperatively inhibits the nucleation of actin filaments; overexpression blocks receptor-mediated endocytosis; protein increases in abundance and forms nuclear foci in response to DNA replication stress; LSB1 has a paralog, PIN3, that arose from the whole genome duplication.


ensembl_gene_id: YGR137W
symbol: YGR137W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YGR137W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YGR138C
symbol: TPO2
gene_biotype: protein_coding
description:
  Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; TPO2 has a paralog, TPO3, that arose from the whole genome duplication; Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.


ensembl_gene_id: YGR139W
symbol: YGR139W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YGR139W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YGR140W
symbol: CBF2
gene_biotype: protein_coding
description:
  Essential kinetochore protein; component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere; Cbf2p also binds to the CDEII region possibly forming a different multimeric complex, ubiquitinated in vivo; sumoylated in an Mms21p-dependent manner; relative distribution to the spindle pole body decreases upon DNA replication stress.


ensembl_gene_id: YGR141W
symbol: VPS62
gene_biotype: protein_coding
description:
  Vacuolar protein sorting (VPS) protein; required for cytoplasm to vacuole targeting of proteins; VPS62 has a paralog, TDA6, that arose from the whole genome duplication.


ensembl_gene_id: YGR142W
symbol: BTN2
gene_biotype: protein_coding
description:
  v-SNARE binding protein; facilitates specific protein retrieval from a late endosome to the Golgi; modulates arginine uptake, possible role in mediating pH homeostasis between the vacuole and plasma membrane H(+)-ATPase; contributes to prion curing; preferentially expressed after severe ethanol stress.


ensembl_gene_id: YGR143W
symbol: SKN1
gene_biotype: protein_coding
description:
  Protein involved in sphingolipid biosynthesis; type II membrane protein; SKN1 has a paralog, KRE6, that arose from the whole genome duplication.


ensembl_gene_id: YGR144W
symbol: THI4
gene_biotype: protein_coding
description:
  Thiazole synthase; abundant protein involved in the formation of the thiazole moiety of thiamine during thiamine biosynthesis; acts more as a co-substrate rather than an enzyme by providing the sulphur source for thiazole formation; undergoes a single turnover only; required for mitochondrial genome stability in response to DNA damaging agents; Belongs to the THI4 family.


ensembl_gene_id: YGR145W
symbol: ENP2
gene_biotype: protein_coding
description:
  Ribosome biogenesis protein ENP2; Component of the SSU; required for pre-18S rRNA processing, biogenesis of the small ribosomal subunit; interacts with U3 snoRNA, Mpp10p and Bfr2p; contains WD repeats, and has homology to Spb1p.


ensembl_gene_id: YGR146C
symbol: ECL1
gene_biotype: protein_coding
description:
  Protein of unknown function; mitochondrial-dependent role in the extension of chronological lifespan; overexpression increases oxygen consumption and respiratory activity while deletion results in reduced oxygen consumption under conditions of caloric restriction; induced by iron homeostasis transcription factor Aft2p; multicopy suppressor of temperature sensitive hsf1 mutant; induced by treatment with 8-methoxypsoralen and UVA irradiation.


ensembl_gene_id: YGR147C
symbol: NAT2
gene_biotype: protein_coding
description:
  Putative N-terminal acetyltransferase 2; Protein of unknown function; has an apparent role in acetylation of N-terminal methionine residues.


ensembl_gene_id: YGR148C
symbol: RPL24B
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L24B; not essential for translation but may be required for normal translation rate; homologous to mammalian ribosomal protein L24, no bacterial homolog; RPL24B has a paralog, RPL24A, that arose from the whole genome duplication.


ensembl_gene_id: YGR149W
symbol: GPC1
gene_biotype: protein_coding
description:
  Glycerophosphocholine acyltransferase (GPCAT); involved in in phosphatidylcholine (PC) synthesis; uses acetyl-CoA to acylate glycero-3-phosphocholine to yield lyso-PC; also catalyzes acylation of glycerophosphoethanolamine with acyl-CoA; predicted to be an integal membrane protein.


ensembl_gene_id: YGR150C
symbol: CCM1
gene_biotype: protein_coding
description:
  Mitochondrial group I intron splicing factor CCM1; Mitochondrial 15S rRNA-binding protein; required for intron removal of COB and COX1 pre-mRNAs; has separable roles in stabilizing mitochondrial 15S rRNA and in maturation of the COB and COX1 mRNAs; contains pentatricopeptide repeat (PPR) motifs; mutant is respiratory deficient and has defective plasma membrane electron transport.


ensembl_gene_id: YGR151C
symbol: YGR151C
gene_biotype: protein_coding
description:
  Uncharacterized protein YGR151C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF RSR1/BUD1/YGR152C; relative distribution to the nucleus increases upon DNA replication stress.


ensembl_gene_id: YGR152C
symbol: RSR1
gene_biotype: protein_coding
description:
  Ras-related protein RSR1; GTP-binding protein of the Ras superfamily; required for bud site selection, morphological changes in response to mating pheromone, and efficient cell fusion; localized to the plasma membrane; significantly similar to mammalian Rap GTPases.


ensembl_gene_id: YGR154C
symbol: GTO1
gene_biotype: protein_coding
description:
  Glutathione S-transferase omega-like 1; Omega-class glutathione transferase; induced under oxidative stress; putative peroxisomal localization.


ensembl_gene_id: YGR155W
symbol: CYS4
gene_biotype: protein_coding
description:
  Cystathionine beta-synthase; catalyzes synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis; responsible for hydrogen sulfide generation; advances passage through START by promoting cell growth which requires catalytic activity, and reducing critical cell size independent of catalytic activity; mutations in human ortholog CBS cause homocystinuria; human CBS can complement yeast null mutant.


ensembl_gene_id: YGR156W
symbol: PTI1
gene_biotype: protein_coding
description:
  Protein PTI1; Essential component of CPF (cleavage and polyadenylation factor); involved in 3' end formation of snoRNA and mRNA; interacts directly with Pta1p; relocalizes to the cytosol in response to hypoxia; similar to mammalian Cleavage-Stimulation Factor CstF-64.


ensembl_gene_id: YGR157W
symbol: CHO2
gene_biotype: protein_coding
description:
  Phosphatidylethanolamine methyltransferase (PEMT); catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis.


ensembl_gene_id: YGR158C
symbol: MTR3
gene_biotype: protein_coding
description:
  Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6).


ensembl_gene_id: YGR159C
symbol: NSR1
gene_biotype: protein_coding
description:
  Nucleolar protein that binds nuclear localization sequences; required for pre-rRNA processing and ribosome biogenesis; binds to single stranded telomeric DNA and mRNA; methylated by Hmt1p; interaction with Top1p and nucleolar localization are negatively regulated by polyphosphorylation.


ensembl_gene_id: YGR160W
symbol: YGR160W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YGR160W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YGR161W-C
symbol: YGR161W-C
gene_biotype: protein_coding
description:
  Uncharacterized protein YGR161W-C; Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species.


ensembl_gene_id: YGR162W
symbol: TIF4631
gene_biotype: protein_coding
description:
  Translation initiation factor eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); interacts with Pab1p and with eIF4A (Tif1p); also has a role in biogenesis of the large ribosomal subunit; TIF4631 has a paralog, TIF4632, that arose from the whole genome duplication.


ensembl_gene_id: YGR163W
symbol: GTR2
gene_biotype: protein_coding
description:
  GTP-binding protein GTR2; Subunit of a TORC1-stimulating GTPase complex; subunit of the Gtr1-Gtr2 GTPase complex that stimulates TORC1 in response to amino acid stimulation; stimulates the GTPase activity of Gtr1p; negatively regulates the Ran/Tc4 GTPase cycle; activates transcription; tethered to the vacuolar membrane as part of the EGO complex (EGOC); required for sorting of Gap1p; activated by the the Lst4p-Lst7p GAP complex; localizes to cytoplasm and to chromatin; homolog of human RagC and.


ensembl_gene_id: YGR164W
symbol: YGR164W
gene_biotype: protein_coding
description:
  Uncharacterized protein YGR164W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YGR165W
symbol: MRPS35
gene_biotype: protein_coding
description:
  Mitochondrial ribosomal protein of the small subunit; null mutant does not grow on glycerol, is sensitive to 2,4-dichlorophenol, and accumulates large lipid droplets.


ensembl_gene_id: YGR166W
symbol: TRS65
gene_biotype: protein_coding
description:
  Trafficking protein particle complex II-specific subunit 65; Component of transport protein particle (TRAPP) complex II; TRAPPII is a multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p, regulating intra-Golgi and endosome-Golgi traffic; role in cell wall beta-glucan biosynthesis and the stress response.


ensembl_gene_id: YGR167W
symbol: CLC1
gene_biotype: protein_coding
description:
  Clathrin light chain; subunit of the major coat protein involved in intracellular protein transport and endocytosis; regulates endocytic progression; thought to regulate clathrin function; the clathrin triskelion is a trimeric molecule composed of three heavy chains that radiate from a vertex and three light chains which bind noncovalently near the vertex of the triskelion.


ensembl_gene_id: YGR169C
symbol: PUS6
gene_biotype: protein_coding
description:
  tRNA:pseudouridine synthase; catalyzes the conversion of uridine to pseudouridine at position 31 in cytoplasmic and mitochondrial tRNAs; mutation of Asp168 to Ala abolishes enzyme activity; not essential for viability.


ensembl_gene_id: YGR169C-A
symbol: LSO2
gene_biotype: protein_coding
description:
  Protein with a potential role in response to iron deprivation; localizes to nucleus and cytoplasm, and nuclear localization is enhanced under iron-replete conditions; null mutant exhibits slow growth during iron deprivation; LSO2 has a paralog, LSO1, that arose from the whole genome duplication.


ensembl_gene_id: YGR170W
symbol: PSD2
gene_biotype: protein_coding
description:
  Phosphatidylserine decarboxylase 2 alpha chain; Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes; converts phosphatidylserine to phosphatidylethanolamine; controls vacuolar membrane phospholipid content by regulating phospholipids in compartments that will eventually give rise to the vacuole; loss of Psd2p causes a specific reduction in vacuolar membrane PE levels while total PE levels are not significantly affected.


ensembl_gene_id: YGR171C
symbol: MSM1
gene_biotype: protein_coding
description:
  Methionine--tRNA ligase, mitochondrial; Mitochondrial methionyl-tRNA synthetase (MetRS); functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p.


ensembl_gene_id: YGR172C
symbol: YIP1
gene_biotype: protein_coding
description:
  Integral membrane protein; required for the biogenesis of ER-derived COPII transport vesicles; interacts with Yif1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles; human homolog YIPF5 can complement yeast yip1 mutant.


ensembl_gene_id: YGR173W
symbol: RBG2
gene_biotype: protein_coding
description:
  Ribosome-interacting GTPase 2; Protein with a role in translation; forms a complex with Gir2p; has similarity to mammalian developmentally regulated GTP-binding protein; Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.


ensembl_gene_id: YGR174C
symbol: CBP4
gene_biotype: protein_coding
description:
  Assembly factor CBP4; Mitochondrial protein required for assembly of cytochrome bc1 complex; interacts with the Cbp3p-Cbp6p complex and newly synthesized cytochrome b (Cobp) to promote assembly of Cobp into the cytochrome bc1 complex.


ensembl_gene_id: YGR174W-A
symbol: YGR174W-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YGR174W-A; Putative protein of unknown function; predicted to have a role in cell budding based on computational guilt by association analysis.


ensembl_gene_id: YGR175C
symbol: ERG1
gene_biotype: protein_coding
description:
  Squalene epoxidase; catalyzes the epoxidation of squalene to 2,3-oxidosqualene; plays an essential role in the ergosterol-biosynthesis pathway and is the specific target of the antifungal drug terbinafine; human SQLE functionally complements the lethality of the erg1 null mutation.


ensembl_gene_id: YGR176W
symbol: YGR176W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YGR176W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YGR177C
symbol: ATF2
gene_biotype: protein_coding
description:
  Alcohol O-acetyltransferase 2; Alcohol acetyltransferase; may play a role in steroid detoxification; forms volatile esters during fermentation, which is important for brewing and winemaking.


ensembl_gene_id: YGR178C
symbol: PBP1
gene_biotype: protein_coding
description:
  PAB1-binding protein 1; Component of glucose deprivation induced stress granules; involved in P-body-dependent granule assembly; similar to human ataxin-2; interacts with Pab1p to regulate mRNA polyadenylation; interacts with Mkt1p to regulate HO translation; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress.


ensembl_gene_id: YGR179C
symbol: OKP1
gene_biotype: protein_coding
description:
  Inner kinetochore subunit OKP1; Outer kinetochore protein required for accurate chromosome segregation; component of COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) a kinetochore sub-complex which functions as a platform for kinetochore assembly; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-Q and fission yeast fta7.


ensembl_gene_id: YGR180C
symbol: RNR4
gene_biotype: protein_coding
description:
  Ribonucleoside-diphosphate reductase small chain 2; Ribonucleotide-diphosphate reductase (RNR) small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits; relocalizes from nucleus to cytoplasm upon DNA replication stress; RNR4 has a paralog, RNR2, that arose from the whole genome duplication.


ensembl_gene_id: YGR181W
symbol: TIM13
gene_biotype: protein_coding
description:
  Mitochondrial import inner membrane translocase subunit TIM13; Mitochondrial intermembrane space protein; forms a complex with Tim8p that delivers a subset of hydrophobic proteins to the TIM22 complex for insertion into the inner membrane.


ensembl_gene_id: YGR182C
symbol: YGR182C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YGR182C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TIM13/YGR181W.


ensembl_gene_id: YGR183C
symbol: QCR9
gene_biotype: protein_coding
description:
  Subunit 9 of ubiquinol cytochrome-c reductase (Complex III); Complex III is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex; Belongs to the UQCR10/QCR9 family.


ensembl_gene_id: YGR184C
symbol: UBR1
gene_biotype: protein_coding
description:
  E3 ubiquitin ligase (N-recognin); heterodimerizes with Rad6p to recognize and ubiquitinate substrates of the N-end rule pathway; role in endoplasmic reticulum-associated protein degradation (ERAD) in the absence of canonical ER membrane ligases or after stress; major role in targeting misfolded cytosolic proteins for degradation; regulates peptide transport via Cup9p ubiquitination; mutation in human UBR1 causes Johansson-Blizzard Syndrome (JBS).


ensembl_gene_id: YGR185C
symbol: TYS1
gene_biotype: protein_coding
description:
  Tyrosine--tRNA ligase, cytoplasmic; Cytoplasmic tyrosyl-tRNA synthetase; required for cytoplasmic protein synthesis; interacts with positions 34 and 35 of the tRNATyr anticodon; mutations in human ortholog YARS are associated with Charcot-Marie-Tooth (CMT) neuropathies; human ortholog YARS functionally complements the heat sensitivity of a ts allele; protein abundance increases in response to DNA replication stress; Belongs to the class-I aminoacyl-tRNA synthetase family.


ensembl_gene_id: YGR186W
symbol: TFG1
gene_biotype: protein_coding
description:
  TFIIF (Transcription Factor II) largest subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP74.


ensembl_gene_id: YGR187C
symbol: HGH1
gene_biotype: protein_coding
description:
  Nonessential protein of unknown function; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; similar to mammalian BRP16 (Brain protein 16); relative distribution to the nucleus increases upon DNA replication stress.


ensembl_gene_id: YGR188C
symbol: BUB1
gene_biotype: protein_coding
description:
  Protein kinase involved in the cell cycle checkpoint into anaphase; in complex with Mad1p and Bub3p, prevents progression into anaphase in presence of spindle damage; Cdc28p-mediated phosphorylation at Bub1p-T566 is important for degradation in anaphase and adaptation of checkpoint to prolonged mitotic arrest; associates with centromere DNA via Skp1p; involved in Sgo1p relocalization in response to sister kinetochore tension; paralog MAD3 arose from whole genome duplication.


ensembl_gene_id: YGR189C
symbol: CRH1
gene_biotype: protein_coding
description:
  Probable glycosidase CRH1; Chitin transglycosylase; functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar and functionally redundant to Utr2; localizes to sites of polarized growth; expression induced by cell wall stress.


ensembl_gene_id: YGR190C
symbol: YGR190C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YGR190C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene HIP1/YGR191W.


ensembl_gene_id: YGR192C
symbol: TDH3
gene_biotype: protein_coding
description:
  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 3; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; GAPDH-derived antimicrobial peptides secreted by S. cerevisiae are active against a wide variety of wine-related yeasts and bacteria; binds AU-rich RNA.


ensembl_gene_id: YGR193C
symbol: PDX1
gene_biotype: protein_coding
description:
  E3-binding protein of the mitochondrial pyruvate dehydrogenase complex; plays a structural role in the complex by binding and positioning dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide acetyltransferase (E2) core.


ensembl_gene_id: YGR194C
symbol: XKS1
gene_biotype: protein_coding
description:
  Xylulokinase; converts D-xylulose and ATP to xylulose 5-phosphate and ADP; rate limiting step in fermentation of xylulose; required for xylose fermentation by recombinant S. cerevisiae strains.


ensembl_gene_id: YGR195W
symbol: SKI6
gene_biotype: protein_coding
description:
  Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp41p (EXOSC4).


ensembl_gene_id: YGR197C
symbol: SNG1
gene_biotype: protein_coding
description:
  Protein involved in resistance to nitrosoguanidine and 6-azauracil; expression is regulated by transcription factors involved in multidrug resistance; SNG1 has a paralog, YJR015W, that arose from the whole genome duplication.


ensembl_gene_id: YGR198W
symbol: YPP1
gene_biotype: protein_coding
description:
  Cargo-transport protein involved in endocytosis; interacts with phosphatidylinositol-4-kinase Stt4p; is required, along with Efr3p, for the assembly and recruitment of multiple copies of the kinase into phosphoinositide kinase (PIK) patches at the plasma membrane; positively regulates Stt4p; GFP-fusion protein localizes to the cytoplasm; YGR198W is an essential gene.


ensembl_gene_id: YGR199W
symbol: PMT6
gene_biotype: protein_coding
description:
  Dolichyl-phosphate-mannose--protein mannosyltransferase 6; Protein O-mannosyltransferase; transfers mannose from dolichyl phosphate-D-mannose to protein serine/threonine residues of secretory proteins; reaction is essential for cell wall rigidity; member of a family of mannosyltransferases.


ensembl_gene_id: YGR200C
symbol: ELP2
gene_biotype: protein_coding
description:
  Subunit of Elongator complex; binds to microtubules via conserved alkaline residues; has two seven-bladed WD40 &#946; propellers; Elongator complex is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin; Belongs to the WD repeat ELP2 family.


ensembl_gene_id: YGR202C
symbol: PCT1
gene_biotype: protein_coding
description:
  Cholinephosphate cytidylyltransferase; a rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding; contains an element within the regulatory domain involved in both silencing and activation of enzymatic activity.


ensembl_gene_id: YGR203W
symbol: YCH1
gene_biotype: protein_coding
description:
  CDC25-like phosphatase YCH1; Phosphatase with sequence similarity to Cdc25p; Arr2p and Mih1p; member of the single-domain rhodanese homology superfamily; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus.


ensembl_gene_id: YGR204C-A
symbol: YGR204C-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YGR204C-A; Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching.


ensembl_gene_id: YGR204W
symbol: ADE3
gene_biotype: protein_coding
description:
  C-1-tetrahydrofolate synthase, cytoplasmic; Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase; involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine; null mutation causes auxotrophy for adenine and histidine.


ensembl_gene_id: YGR205W
symbol: TDA10
gene_biotype: protein_coding
description:
  Probable ATP-dependent kinase TDA10; ATP-binding protein of unknown function; crystal structure resembles that of E.coli pantothenate kinase and other small kinases; null mutant is sensitive to expression of the top1-T722A allele.


ensembl_gene_id: YGR206W
symbol: MVB12
gene_biotype: protein_coding
description:
  Multivesicular body sorting factor 12; ESCRT-I subunit required to stabilize ESCRT-I core complex oligomers; the ESCRT-I core complex (Stp22p, Vps28p, Srn2p) is involved in ubiquitin-dependent sorting of proteins into the endosome; deletion mutant is sensitive to rapamycin and nystatin.


ensembl_gene_id: YGR207C
symbol: CIR1
gene_biotype: protein_coding
description:
  Probable electron transfer flavoprotein subunit beta; Mitochondrial protein that interacts with frataxin (Yfh1p); putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-beta; may have a role in oxidative stress response.


ensembl_gene_id: YGR208W
symbol: SER2
gene_biotype: protein_coding
description:
  Phosphoserine phosphatase of the phosphoglycerate pathway; involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source.


ensembl_gene_id: YGR209C
symbol: TRX2
gene_biotype: protein_coding
description:
  Thioredoxin-2; Cytoplasmic thioredoxin isoenzyme; part of thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p; required for ER-Golgi transport and vacuole inheritance; with Trx1p, facilitates mitochondrial import of small Tims Tim9p, Tim10p, Tim13p by maintaining them in reduced form; abundance increases under DNA replication stress; TRX2 has a paralog, TRX1, that arose from the whole genome duplication.


ensembl_gene_id: YGR210C
symbol: YGR210C
gene_biotype: protein_coding
description:
  Uncharacterized GTP-binding protein YGR210C; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm.


ensembl_gene_id: YGR211W
symbol: ZPR1
gene_biotype: protein_coding
description:
  Essential protein with two zinc fingers; present in nucleus of growing cells, relocates to cytoplasm in starved cells via a process mediated by Cpr1p; binds translation elongation factor eEF-1 (Tef1p); relative distribution to nucleus increases upon DNA replication stress; human ZPR1 gene can complement yeast by allowing growth during down-regulation of yeast zpr1.


ensembl_gene_id: YGR212W
symbol: SLI1
gene_biotype: protein_coding
description:
  N-acetyltransferase; confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin.


ensembl_gene_id: YGR213C
symbol: RTA1
gene_biotype: protein_coding
description:
  Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of protein; RTA1 has a paralog, YLR046C, that arose from the whole genome duplication; Belongs to the lipid-translocating exporter (LTE) (TC 9.A.26.1) family.


ensembl_gene_id: YGR214W
symbol: RPS0A
gene_biotype: protein_coding
description:
  Ribosomal 40S subunit protein S0A; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2; RPS0A has a paralog, RPS0B, that arose from the whole genome duplication.


ensembl_gene_id: YGR216C
symbol: GPI1
gene_biotype: protein_coding
description:
  Phosphatidylinositol N-acetylglucosaminyltransferase subunit GPI1; Membrane protein involved in the synthesis of GlcNAc-PI; N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI) is the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; human and mouse GPI1p are functional homologs.


ensembl_gene_id: YGR217W
symbol: CCH1
gene_biotype: protein_coding
description:
  Calcium-channel protein CCH1; Voltage-gated high-affinity calcium channel; involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and partially co-localizes with Mid1p; however, evidence suggests CCH1 is not required for Mid1p function.


ensembl_gene_id: YGR218W
symbol: CRM1
gene_biotype: protein_coding
description:
  Exportin-1; Major karyopherin; involved in export of proteins, RNAs, and ribosomal subunits from the nucleus; exportin.


ensembl_gene_id: YGR219W
symbol: YGR219W
gene_biotype: protein_coding
description:
  Uncharacterized protein YGR219W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRPL9/YGR220C.


ensembl_gene_id: YGR221C
symbol: TOS2
gene_biotype: protein_coding
description:
  Protein involved in localization of Cdc24p to the site of bud growth; may act as a membrane anchor; localizes to the bud neck and bud tip; potentially phosphorylated by Cdc28p; TOS2 has a paralog, SKG6, that arose from the whole genome duplication; Belongs to the SKG6/TOS2 family.


ensembl_gene_id: YGR222W
symbol: PET54
gene_biotype: protein_coding
description:
  Protein PET54; Mitochondrial inner membrane protein; binds to the 5' UTR of the COX3 mRNA to activate its translation together with Pet122p and Pet494p; also binds to the COX1 Group I intron AI5 beta to facilitate exon ligation during splicing.


ensembl_gene_id: YGR223C
symbol: HSV2
gene_biotype: protein_coding
description:
  SVP1-like protein 2; Phosphatidylinositol 3,5-bisphosphate-binding protein; plays a role in micronucleophagy; belongs to the PROPPIN family of proteins; predicted to fold as a seven-bladed beta-propeller; displays punctate cytoplasmic localization; Belongs to the WD repeat SVP1 family.


ensembl_gene_id: YGR224W
symbol: AZR1
gene_biotype: protein_coding
description:
  Azole resistance protein 1; Plasma membrane transporter of the major facilitator superfamily; involved in resistance to azole drugs such as ketoconazole and fluconazole.


ensembl_gene_id: YGR225W
symbol: AMA1
gene_biotype: protein_coding
description:
  Meiosis-specific APC/C activator protein AMA1; Activator of meiotic anaphase promoting complex (APC/C); Cdc20p family member; required for initiation of spore wall assembly; required for Clb1p degradation during meiosis; prevents premature assembly of the meiosis I spindle, required for DSB induced prophase I arrest; Belongs to the WD repeat CDC20/Fizzy family.


ensembl_gene_id: YGR226C
symbol: YGR226C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YGR226C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; overlaps significantly with a verified ORF, AMA1/YGR225W.


ensembl_gene_id: YGR227W
symbol: DIE2
gene_biotype: protein_coding
description:
  Dolichyl-phosphoglucose-dependent alpha-1,2-glucosyltransferase; located in the ER; functions in pathway that synthesizes the dolichol-linked oligosaccharide precursor for N-linked protein glycosylation; has a role in regulation of ITR1 and INO1; human homolog ALG10B can complement yeast die2 null mutant.


ensembl_gene_id: YGR228W
symbol: YGR228W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YGR228W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SMI1/YGR229C.


ensembl_gene_id: YGR229C
symbol: SMI1
gene_biotype: protein_coding
description:
  Cell wall assembly regulator SMI1; Protein involved in the regulation of cell wall synthesis; proposed to be involved in coordinating cell cycle progression with cell wall integrity.


ensembl_gene_id: YGR230W
symbol: BNS1
gene_biotype: protein_coding
description:
  Protein of unknown function; overexpression bypasses need for Spo12p, but not required for meiosis; BNS1 has a paralog, SPO12, that arose from the whole genome duplication.


ensembl_gene_id: YGR231C
symbol: PHB2
gene_biotype: protein_coding
description:
  Prohibitin-2; Subunit of the prohibitin complex (Phb1p-Phb2p); prohibitin is a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation; prohibitin deficiency induces a mitochondrial unfolded protein response (mtUPR).


ensembl_gene_id: YGR232W
symbol: NAS6
gene_biotype: protein_coding
description:
  Probable 26S proteasome regulatory subunit p28; Evolutionarily conserved 19S regulatory particle assembly-chaperone; proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); ortholog of human oncoprotein gankyrin, also known as p28, which interacts with the Rb tumor suppressor and CDK4/6.


ensembl_gene_id: YGR233C
symbol: PHO81
gene_biotype: protein_coding
description:
  Phosphate system positive regulatory protein PHO81; Cyclin-dependent kinase (CDK) inhibitor; regulates Pho80p-Pho85p and Pcl7p-Pho85p cyclin-CDK complexes in response to phosphate levels; inhibitory activity for Pho80p-Pho85p requires myo-D-inositol heptakisphosphate (IP7) generated by Vip1p; relative distribution to the nucleus increases upon DNA replication stress.


ensembl_gene_id: YGR234W
symbol: YHB1
gene_biotype: protein_coding
description:
  Flavohemoprotein; Nitric oxide oxidoreductase; flavohemoglobin that plays role in oxidative and nitrosative stress responses; protects against nitration of cellular targets and against cell growth inhibition under aerobic or anaerobic conditions; yeast flavohemoglobin Yhb1p and human homolog neuroglobin NGB protect cells against alpha-synuclein cytotoxicity and aggregate formation; protein increases in abundance, relocalizes from nucleus to cytoplasmic foci upon DNA replication stress; Belongs to the globin family. Two-domain flavohemoproteins subfamily.


ensembl_gene_id: YGR235C
symbol: MIC26
gene_biotype: protein_coding
description:
  MICOS subunit MIC26; Component of the MICOS complex; MICOS (formerly MINOS or MitOS) is a mitochondrial inner membrane complex that extends into the intermembrane space and has a role in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane; Mic26p is a non-essential component of the complex.


ensembl_gene_id: YGR236C
symbol: SPG1
gene_biotype: protein_coding
description:
  Stationary phase gene 1 protein; Protein required for high temperature survival during stationary phase; not required for growth on nonfermentable carbon sources; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies.


ensembl_gene_id: YGR237C
symbol: YGR237C
gene_biotype: protein_coding
description:
  Uncharacterized protein YGR237C; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm.


ensembl_gene_id: YGR238C
symbol: KEL2
gene_biotype: protein_coding
description:
  Kelch repeat-containing protein 2; Protein that negatively regulates mitotic exit; forms a complex with Kel1p and Bud14p that regulates Bnr1p (formin) to affect actin cable assembly, cytokinesis, and polarized growth; functions in a complex with Kel1p, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate.


ensembl_gene_id: YGR239C
symbol: PEX21
gene_biotype: protein_coding
description:
  Peroxin required for peroxisomal matrix protein targeting; acts on proteins containing the PTS2 targeting sequence; interacts with Pex7p; constitutively expressed; partially redundant with Pex18p; required for import of the Gpd1p-Pnc1p heterodimer in which only Gpd1p has a peroxisomal targeting signal; relative distribution to cytoplasmic foci increases upon DNA replication stress; Belongs to the peroxin-21 family.


ensembl_gene_id: YGR240C
symbol: PFK1
gene_biotype: protein_coding
description:
  Alpha subunit of heterooctameric phosphofructokinase; involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.


ensembl_gene_id: YGR240C-A
symbol: YGR240C-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YGR240C-A; Putative protein of unknown function; identified by fungal homology and RT-PCR.


ensembl_gene_id: YGR241C
symbol: YAP1802
gene_biotype: protein_coding
description:
  Protein of the AP180 family, involved in clathrin cage assembly; binds Pan1p and clathrin; YAP1802 has a paralog, YAP1801, that arose from the whole genome duplication; Belongs to the AP180 family.


ensembl_gene_id: YGR242W
symbol: YGR242W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YGR242W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YAP1802/YGR241C.


ensembl_gene_id: YGR243W
symbol: MPC3
gene_biotype: protein_coding
description:
  Highly conserved subunit of the mitochondrial pyruvate carrier (MPC); expressed during growth on nonfermentable carbon sources, and heterodimerizes with Mpc1p to form the respiratory isoform of MPC; MPC localizes to the mitochondrial inner membrane and mediates pyruvate uptake; MPC3 paralog, MPC2, heterodimerizes with Mpc1p to form the fermentative MPC isoform; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YGR244C
symbol: LSC2
gene_biotype: protein_coding
description:
  Beta subunit of succinyl-CoA ligase; succinyl-CoA ligase is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate.


ensembl_gene_id: YGR245C
symbol: SDA1
gene_biotype: protein_coding
description:
  Protein required for actin organization and passage through Start; highly conserved nuclear protein; required for actin cytoskeleton organization; plays a critical role in G1 events; binds Nap1p; involved in 60S ribosome biogenesis; Belongs to the SDA1 family.


ensembl_gene_id: YGR246C
symbol: BRF1
gene_biotype: protein_coding
description:
  TFIIIB B-related factor; one of three subunits of RNA polymerase III transcription initiation factor TFIIIB, binds TFIIIC and TBP and recruits RNA pol III to promoters, amino-terminal half is homologous to TFIIB; mutations in human homolog are associated with autosomal recessive cerebellar-facial-dental syndrome.


ensembl_gene_id: YGR247W
symbol: CPD1
gene_biotype: protein_coding
description:
  2',3'-cyclic-nucleotide 3'-phosphodiesterase; Cyclic nucleotide phosphodiesterase; hydrolyzes ADP-ribose 1'', 2''-cyclic phosphate to ADP-ribose 1''-phosphate; may have a role in tRNA splicing; no detectable phenotype is conferred by null mutation or by overexpression; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YGR248W
symbol: SOL4
gene_biotype: protein_coding
description:
  6-phosphogluconolactonase; protein abundance increases in response to DNA replication stress; SOL4 has a paralog, SOL3, that arose from the whole genome duplication.


ensembl_gene_id: YGR249W
symbol: MGA1
gene_biotype: protein_coding
description:
  Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants.


ensembl_gene_id: YGR250C
symbol: RIE1
gene_biotype: protein_coding
description:
  Uncharacterized RNA-binding protein YGR250C; Putative RNA binding protein; localizes to stress granules induced by glucose deprivation; interacts with Rbg1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YGR251W
symbol: NOP19
gene_biotype: protein_coding
description:
  Nucleolar protein 19; Ribosome biogenesis factor; nucleolar protein associated with pre-rRNA components of the 90S preribosome, required for cleavage of pre-rRNA at A0, A1 and A2 sites; interacts with RNA helicase Dhr2p and RNA helicase-like protein Utp25p; required for incorporation of Utp25p into preribosomes.


ensembl_gene_id: YGR252W
symbol: GCN5
gene_biotype: protein_coding
description:
  Catalytic subunit of ADA and SAGA histone acetyltransferase complexes; modifies N-terminal lysines on histones H2B and H3; acetylates Rsc4p, a subunit of the RSC chromatin-remodeling complex, altering replication stress tolerance; relocalizes to the cytosol in response to hypoxia; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; greater involvement in repression of RNAPII-dependent transcription than in activation; Belongs to the acetyltransferase family. GCN5 subfamily.


ensembl_gene_id: YGR253C
symbol: PUP2
gene_biotype: protein_coding
description:
  Alpha 5 subunit of the 20S proteasome; involved in ubiquitin-dependent catabolism; human homolog is subunit zeta; Belongs to the peptidase T1A family.


ensembl_gene_id: YGR254W
symbol: ENO1
gene_biotype: protein_coding
description:
  Enolase I, a phosphopyruvate hydratase; catalyzes conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression repressed in response to glucose; protein abundance increases in response to DNA replication stress; N-terminally propionylated in vivo; ENO1 has a paralog, ENO2, that arose from the whole genome duplication.


ensembl_gene_id: YGR255C
symbol: COQ6
gene_biotype: protein_coding
description:
  Flavin-dependent monooxygenase involved in ubiquinone biosynthesis; responsible for hydroxylation at position C5 and deamination at C4 during ubiquinone (Coenzyme Q) biosynthesis; localizes to matrix face of mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human homolog COQ6 can complement yeast null mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS).


ensembl_gene_id: YGR256W
symbol: GND2
gene_biotype: protein_coding
description:
  6-phosphogluconate dehydrogenase (decarboxylating); catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone; GND2 has a paralog, GND1, that arose from the whole genome duplication.


ensembl_gene_id: YGR257C
symbol: MTM1
gene_biotype: protein_coding
description:
  Mitochondrial protein of the mitochondrial carrier family; high affinity pyridoxal 5'-phosphate (PLP) transporter, important for delivery of PLP cofactor to mitochondrial enzymes; involved in mitochondrial iron homeostasis and in activating mitochondrial Sod2p by facilitating insertion of an essential manganese cofactor.


ensembl_gene_id: YGR258C
symbol: RAD2
gene_biotype: protein_coding
description:
  DNA repair protein RAD2; Single-stranded DNA endonuclease; cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein.


ensembl_gene_id: YGR259C
symbol: YGR259C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YGR259C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF TNA1/YGR260W.


ensembl_gene_id: YGR260W
symbol: TNA1
gene_biotype: protein_coding
description:
  High affinity nicotinic acid plasma membrane permease; responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA); Belongs to the major facilitator superfamily. Allantoate permease family.


ensembl_gene_id: YGR261C
symbol: APL6
gene_biotype: protein_coding
description:
  Beta3-like subunit of the yeast AP-3 complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; exists in both cytosolic and peripherally associated membrane-bound pools.


ensembl_gene_id: YGR262C
symbol: BUD32
gene_biotype: protein_coding
description:
  Protein kinase; component of the EKC/KEOPS complex with Kae1p, Cgi121p, Pcc1p, and Gon7p; Pyrococcus Bud32 ortholog functions as a P-loop ATPase rather than a protein kinase in the context of the complex; EKC/KEOPS complex is required for t6A tRNA modification and telomeric TG1-3 recombination; may have role in transcription; mutation is functionally complemented by human TP53RK.


ensembl_gene_id: YGR263C
symbol: SAY1
gene_biotype: protein_coding
description:
  Steryl acetyl hydrolase 1; Sterol deacetylase; component of the sterol acetylation/deacetylation cycle along with Atf2p; active both in the endoplasmic reticulum (ER) and in lipid droplets; integral membrane protein with active site in the ER lumen; green fluorescent protein (GFP)-fusion protein localizes to the ER; Belongs to the 'GDXG' lipolytic enzyme family.


ensembl_gene_id: YGR264C
symbol: MES1
gene_biotype: protein_coding
description:
  Methionine--tRNA ligase, cytoplasmic; Methionyl-tRNA synthetase; forms a complex with glutamyl-tRNA synthetase (Gus1p) and Arc1p, which increases the catalytic efficiency of both tRNA synthetases; also has a role in nuclear export of tRNAs; mutations in human ortholog MARS are associated with pediatric pulmonary alveolar proteinosis.


ensembl_gene_id: YGR265W
symbol: YGR265W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YGR265W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MES1/YGR264C, which encodes methionyl-tRNA synthetase.


ensembl_gene_id: YGR266W
symbol: YGR266W
gene_biotype: protein_coding
description:
  Uncharacterized protein YGR266W; Protein of unknown function; predicted to contain a single transmembrane domain; mutant has increased aneuploidy tolerance; localized to both the mitochondrial outer membrane and the plasma membrane; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YGR267C
symbol: FOL2
gene_biotype: protein_coding
description:
  GTP-cyclohydrolase I, catalyzes first step in folic acid biosynthesis; human homolog GCH1 is implicated in dopa-responsive dystonia (DRD), and can complement yeast null mutant.


ensembl_gene_id: YGR268C
symbol: HUA1
gene_biotype: protein_coding
description:
  Proline-rich protein HUA1; Cytoplasmic protein containing a zinc finger domain; sequence similarity to that of Type I J-proteins; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly.


ensembl_gene_id: YGR269W
symbol: YGR269W
gene_biotype: protein_coding
description:
  Uncharacterized protein YGR269W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF HUA1/YGR268C.


ensembl_gene_id: YGR270C-A
symbol: YGR270C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YGR270C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF YTA7/YGR270W.


ensembl_gene_id: YGR270W
symbol: YTA7
gene_biotype: protein_coding
description:
  Tat-binding homolog 7; Protein that localizes to chromatin; has a role in regulation of histone gene expression; has a bromodomain-like region that interacts with the N-terminal tail of histone H3, and an ATPase domain; relocalizes to the cytosol in response to hypoxia; potentially phosphorylated by Cdc28p.


ensembl_gene_id: YGR271C-A
symbol: EFG1
gene_biotype: protein_coding
description:
  rRNA-processing protein EFG1; Essential protein required for maturation of 18S rRNA; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus.


ensembl_gene_id: YGR271W
symbol: SLH1
gene_biotype: protein_coding
description:
  Antiviral helicase SLH1; Putative RNA helicase related to Ski2p; involved in translation inhibition of non-poly(A) mRNAs; required for repressing propagation of dsRNA viruses; Belongs to the helicase family. SKI2 subfamily.


ensembl_gene_id: YGR273C
symbol: YGR273C
gene_biotype: protein_coding
description:
  Uncharacterized protein YGR273C; Putative protein of unknown function; expression downregulated by treatment with 8-methoxypsoralen plus UVA irradiation; not an essential gene; YGR273C has a paralog, YMR295C, that arose from the whole genome duplication; To yeast YMR295c.


ensembl_gene_id: YGR274C
symbol: TAF1
gene_biotype: protein_coding
description:
  TFIID subunit, involved in RNA pol II transcription initiation; possesses in vitro histone acetyltransferase activity but its role in vivo appears to be minor; involved in promoter binding and G1/S progression; relocalizes to the cytosol in response to hypoxia.


ensembl_gene_id: YGR275W
symbol: RTT102
gene_biotype: protein_coding
description:
  Regulator of Ty1 transposition protein 102; Component of both the SWI/SNF and RSC chromatin remodeling complexes; suggested role in chromosome maintenance; possible weak regulator of Ty1 transposition; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YGR276C
symbol: RNH70
gene_biotype: protein_coding
description:
  RNA exonuclease 1; 3'-5' exoribonuclease; required for maturation of 3' ends of 5S rRNA and tRNA-Arg3 from dicistronic transcripts; Belongs to the REXO1/REXO3 family.


ensembl_gene_id: YGR277C
symbol: CAB4
gene_biotype: protein_coding
description:
  Phosphopantetheine adenylyltransferase; Subunit of the CoA-Synthesizing Protein Complex (CoA-SPC); subunits of this complex are: Cab2p, Cab3p, Cab4p, Cab5p, Sis2p and Vhs3p; probable pantetheine-phosphate adenylyltransferase (PPAT); PPAT catalyzes the fourth step in the biosynthesis of coenzyme A from pantothenate; null mutant lethality is complemented by E. coli coaD (encoding PPAT) and by human COASY.


ensembl_gene_id: YGR278W
symbol: CWC22
gene_biotype: protein_coding
description:
  Pre-mRNA-splicing factor CWC22; Spliceosome-associated protein that is required for pre-mRNA splicing; necessary for Prp2p function at the first catalytic step of splicing; has similarity to S. pombe Cwf22p; CWC22 is an essential protein.


ensembl_gene_id: YGR279C
symbol: SCW4
gene_biotype: protein_coding
description:
  Probable family 17 glucosidase SCW4; Cell wall protein with similarity to glucanases; scw4 scw10 double mutants exhibit defects in mating; SCW4 has a paralog, SCW10, that arose from the whole genome duplication; Belongs to the glycosyl hydrolase 17 family.


ensembl_gene_id: YGR280C
symbol: PXR1
gene_biotype: protein_coding
description:
  Essential protein involved in rRNA and snoRNA maturation; competes with TLC1 RNA for binding to Est2p, suggesting a role in negative regulation of telomerase; human homolog inhibits telomerase; contains a G-patch RNA interacting domain.


ensembl_gene_id: YGR281W
symbol: YOR1
gene_biotype: protein_coding
description:
  Oligomycin resistance ATP-dependent permease YOR1; Plasma membrane ATP-binding cassette (ABC) transporter; multidrug transporter mediates export of many different organic anions including oligomycin; homolog of human cystic fibrosis transmembrane receptor (CFTR).


ensembl_gene_id: YGR282C
symbol: BGL2
gene_biotype: protein_coding
description:
  Endo-beta-1,3-glucanase; major protein of the cell wall, involved in cell wall maintenance; involved in incorporation of newly synthesized mannoprotein molecules into the cell wall.


ensembl_gene_id: YGR283C
symbol: YGR283C
gene_biotype: protein_coding
description:
  Putative methyltransferase; may interact with ribosomes, based on co-purification experiments; predicted to be involved in ribosome biogenesis; null mutant is resistant to fluconazole; GFP-fusion protein localizes to the nucleolus; YGR283C has a paralog, YMR310C, that arose from the whole genome duplication; Belongs to the class IV-like SAM-binding methyltransferase superfamily.


ensembl_gene_id: YGR284C
symbol: ERV29
gene_biotype: protein_coding
description:
  Protein localized to COPII-coated vesicles; involved in vesicle formation and incorporation of specific secretory cargo; protein abundance increases in response to DNA replication stress; Belongs to the SURF4 family.


ensembl_gene_id: YGR285C
symbol: ZUO1
gene_biotype: protein_coding
description:
  Zuotin; Ribosome-associated chaperone; zuotin functions in ribosome biogenesis and as a chaperone for nascent polypeptide chains in partnership with Ssz1p and SSb1/2; contains a DnaJ domain and functions as a J-protein partner for Ssb1p and Ssb2p; human gene DNAJC2 can partially complement yeast zuo1 null mutant.


ensembl_gene_id: YGR286C
symbol: BIO2
gene_biotype: protein_coding
description:
  Biotin synthase, mitochondrial; Biotin synthase; catalyzes the conversion of dethiobiotin to biotin, which is the last step of the biotin biosynthesis pathway; complements E. coli bioB mutant; Belongs to the radical SAM superfamily. Biotin synthase family.


ensembl_gene_id: YGR287C
symbol: IMA1
gene_biotype: protein_coding
description:
  Oligo-1,6-glucosidase IMA1; Major isomaltase (alpha-1,6-glucosidase/alpha-methylglucosidase); required for isomaltose utilization; preferred specificity for isomaltose, alpha-methylglucoside, and palatinose, but also exhibits alpha-1,2 glucosidase activity on sucrose and kojibiose, and can cleave the 1,3-alpha linkage of nigerose and turanose and the alpha-1,5 linkage of leucrose in vitro; member of the IMA isomaltase family; Belongs to the glycosyl hydrolase 13 family.


ensembl_gene_id: YGR288W
symbol: MAL13
gene_biotype: protein_coding
description:
  Maltose fermentation regulatory protein MAL13; MAL-activator protein; part of complex locus MAL1; nonfunctional in genomic reference strain S288C; Belongs to the MAL13 family.


ensembl_gene_id: YGR289C
symbol: MAL11
gene_biotype: protein_coding
description:
  General alpha-glucoside permease; High-affinity maltose transporter (alpha-glucoside transporter); inducible; encoded in the MAL1 complex locus; broad substrate specificity that includes maltotriose; required for isomaltose utilization.


ensembl_gene_id: YGR290W
symbol: YGR290W
gene_biotype: protein_coding
description:
  Putative uncharacterized membrane protein YGR290W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; putative HLH protein; partially overlaps the verified ORF MAL11/YGR289C (a high-affinity maltose transporter).


ensembl_gene_id: YGR291C
symbol: YGR291C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YGR291C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YGR292W
symbol: MAL12
gene_biotype: protein_coding
description:
  Alpha-glucosidase MAL12; Maltase (alpha-D-glucosidase); inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose; Belongs to the glycosyl hydrolase 13 family.


ensembl_gene_id: YGR293C
symbol: YGR293C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YGR293C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YGR294W.


ensembl_gene_id: YGR294W
symbol: PAU12
gene_biotype: protein_coding
description:
  Seripauperin-12; Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions; SWAT-GFP fusion protein localizes to both the endoplasmic reticulum and vacuole.


ensembl_gene_id: YGR296C-A
symbol: YGR296C-A
gene_biotype: protein_coding
description:
  Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps TEL07R.


ensembl_gene_id: YGR296C-B
symbol: YGR296C-B
gene_biotype: protein_coding
description:
  Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; contained completely within TEL07R.


ensembl_gene_id: YGR296W
symbol: YRF1-3
gene_biotype: protein_coding
description:
  Y' element ATP-dependent helicase protein 1 copy 3; Helicase encoded by the Y' element of subtelomeric regions; highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p.


ensembl_gene_id: YHL001W
symbol: RPL14B
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L14B; homologous to mammalian ribosomal protein L14, no bacterial homolog; RPL14B has a paralog, RPL14A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YHL002C-A
symbol: YHL002C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized membrane protein YHL002C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF HSE1/YHL002W.


ensembl_gene_id: YHL002W
symbol: HSE1
gene_biotype: protein_coding
description:
  Class E vacuolar protein-sorting machinery protein HSE1; Subunit of the endosomal Vps27p-Hse1p complex; complex is required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes.


ensembl_gene_id: YHL003C
symbol: LAG1
gene_biotype: protein_coding
description:
  Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p; forms ER foci upon DNA replication stress; homolog of human CERS2, a tumor metastasis suppressor gene whose silencing enhances invasion/metastasis of prostate cancer cells; LAG1 has a paralog, LAC1, that arose from the whole genome duplication.


ensembl_gene_id: YHL005C
symbol: YHL005C
gene_biotype: protein_coding
description:
  Uncharacterized protein YHL005C; Putative protein of unknown function; conserved among S. cerevisiae strains; YHL005C is not an essential gene.


ensembl_gene_id: YHL006C
symbol: SHU1
gene_biotype: protein_coding
description:
  Suppressor of HU sensitivity involved in recombination protein 1; Component of Shu complex (aka PCSS complex); Shu complex also includes Psy3, Csm2, Shu2, and promotes error-free DNA repair, mediates inhibition of Srs2p function; essential for promoting the establishment of homolog bias during meiotic homologous recombination; promotes both crossover (CO) and non-crossover (NCO) pathways of meiotic recombination and formation of Rad51p filaments.


ensembl_gene_id: YHL006W-A
symbol: YHL006W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YHL006W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF STE20/YHL007C.


ensembl_gene_id: YHL007C
symbol: STE20
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase STE20; Cdc42p-activated signal transducing kinase; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p; member of the PAK (p21-activated kinase) family; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.


ensembl_gene_id: YHL008C
symbol: YHL008C
gene_biotype: protein_coding
description:
  Uncharacterized transporter YHL008C; Putative protein of unknown function; may be involved in the uptake of chloride ions; does not appear to be involved in monocarboxylic acid transport; green fluorescent protein (GFP)-fusion protein localizes to the vacuole.


ensembl_gene_id: YHL010C
symbol: ETP1
gene_biotype: protein_coding
description:
  RING finger protein ETP1; Protein of unknown function required for growth on ethanol; contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localization sequences.


ensembl_gene_id: YHL011C
symbol: PRS3
gene_biotype: protein_coding
description:
  Ribose-phosphate pyrophosphokinase 3; 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; Belongs to the ribose-phosphate pyrophosphokinase family.


ensembl_gene_id: YHL012W
symbol: YHL012W
gene_biotype: protein_coding
description:
  Probable UTP--glucose-1-phosphate uridylyltransferase; Putative UTP glucose-1-phosphate uridylyltransferase; YHL012W has a paralog, UGP1, that arose from the whole genome duplication; Belongs to the UDPGP type 1 family.


ensembl_gene_id: YHL013C
symbol: OTU2
gene_biotype: protein_coding
description:
  OTU domain-containing protein 2; Protein of unknown function; may interact with ribosomes, based on co-purification experiments; member of the ovarian tumor-like (OTU) superfamily of predicted cysteine proteases; shows cytoplasmic localization; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YHL014C
symbol: YLF2
gene_biotype: protein_coding
description:
  Obg-like ATPase homolog; Protein of unknown function; has weak similarity to E. coli GTP-binding protein gtp1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies.


ensembl_gene_id: YHL015W
symbol: RPS20
gene_biotype: protein_coding
description:
  Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; homologous to mammalian ribosomal protein S20 and bacterial S10.


ensembl_gene_id: YHL016C
symbol: DUR3
gene_biotype: protein_coding
description:
  Plasma membrane transporter for both urea and polyamines; expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.


ensembl_gene_id: YHL017W
symbol: YHL017W
gene_biotype: protein_coding
description:
  Uncharacterized membrane protein YHL071W; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein co-localizes with clathrin-coated vesicles; YHL017W has a paralog, PTM1, that arose from the whole genome duplication; Belongs to the LU7TM family.


ensembl_gene_id: YHL018W
symbol: YHL018W
gene_biotype: protein_coding
description:
  Putative 4a-hydroxytetrahydrobiopterin dehydratase; green fluorescent protein (GFP)-fusion protein localizes to mitochondria and is induced in response to the DNA-damaging agent MMS.


ensembl_gene_id: YHL019C
symbol: APM2
gene_biotype: protein_coding
description:
  Protein of unknown function; homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport; Belongs to the adaptor complexes medium subunit family.


ensembl_gene_id: YHL019W-A
symbol: YHL019W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized membrane protein YHL019W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene APM2/YHL019C.


ensembl_gene_id: YHL020C
symbol: OPI1
gene_biotype: protein_coding
description:
  Transcriptional repressor OPI1; Transcriptional regulator of a variety of genes; phosphorylation by protein kinase A stimulates Opi1p function in negative regulation of phospholipid biosynthetic genes; involved in telomere maintenance; null exhibits disrupted mitochondrial metabolism and low cardiolipin content, strongly correlated with overproduction of inositol; binds to phosphatidic acid.


ensembl_gene_id: YHL021C
symbol: AIM17
gene_biotype: protein_coding
description:
  Probable oxidoreductase AIM17; Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss; Belongs to the gamma-BBH/TMLD family.


ensembl_gene_id: YHL022C
symbol: SPO11
gene_biotype: protein_coding
description:
  Meiosis-specific protein that initiates meiotic recombination; initiates meiotic recombination by catalyzing the formation of double-strand breaks in DNA via a transesterification reaction; required for homologous chromosome pairing and synaptonemal complex formation; Belongs to the TOP6A family.


ensembl_gene_id: YHL023C
symbol: NPR3
gene_biotype: protein_coding
description:
  Nitrogen permease regulator 3; Subunit of the Iml1p/SEACIT complex; SEACIT (Iml1p-Npr2p-Npr3p) is a subcomplex of SEAC, a coatomer-related complex that associates dynamically with the vacuole; Npr3p may have a structural or regulatory role, supporting Iml1p function as a GAP for the Rag family GTPase Gtr1p, and leading to inhibition of TORC1 signaling in response to amino acid deprivation; SEACIT is required for non-nitrogen-starvation-induced autophagy; null mutant has meiotic defects; human NPRL3 homolog.


ensembl_gene_id: YHL024W
symbol: RIM4
gene_biotype: protein_coding
description:
  Meiotic activator RIM4; Putative RNA-binding protein; required for the expression of early and middle sporulation genes.


ensembl_gene_id: YHL025W
symbol: SNF6
gene_biotype: protein_coding
description:
  Transcription regulatory protein SNF6; Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf5p; relocates to the cytosol under hypoxic conditions.


ensembl_gene_id: YHL026C
symbol: YHL026C
gene_biotype: protein_coding
description:
  Uncharacterized protein YHL026C; Putative protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; SWAT-GFP fusion protein localizes to the cell periphery, while mCherry fusion localizes to both the cell periphery and vacuole; YHL026C is not an essential gene; in 2005 the start site was moved 141 nt upstream (see Locus History).


ensembl_gene_id: YHL027W
symbol: RIM101
gene_biotype: protein_coding
description:
  pH-response transcription factor pacC/RIM101; Cys2His2 zinc-finger transcriptional repressor; involved in alkaline responsive gene repression as part of adaptation to alkaline conditions; involved in cell wall assembly; required for alkaline pH-stimulated haploid invasive growth and sporulation; activated by alkaline-dependent proteolytic processing which results in removal of the C-terminal tail; similar to A. nidulans PacC; Belongs to the pacC/RIM101 family.


ensembl_gene_id: YHL028W
symbol: WSC4
gene_biotype: protein_coding
description:
  Cell wall integrity and stress response component 4; Endoplasmic reticulum (ER) membrane protein; involved in the translocation of soluble secretory proteins and insertion of membrane proteins into the ER membrane; may also have a role in the stress response but has only partial functional overlap with WSC1-3.


ensembl_gene_id: YHL029C
symbol: OCA5
gene_biotype: protein_coding
description:
  Oxidant-induced cell-cycle arrest protein 5; Cytoplasmic protein required for replication of Brome mosaic virus; S. cerevisiae is a model system for studying replication of positive-strand RNA viruses in their natural hosts; Belongs to the OCA5 family.


ensembl_gene_id: YHL030W
symbol: ECM29
gene_biotype: protein_coding
description:
  Proteasome component ECM29; Scaffold protein; assists in association of the proteasome core particle with the regulatory particle; inhibits proteasomal ATPase activity; degraded by the mature proteasome after assembly; contains HEAT-like repeats; protein increases in abundance and relocalizes from nucleus to cytoplasm upon DNA replication stress; Belongs to the ECM29 family.


ensembl_gene_id: YHL030W-A
symbol: YHL030W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YHL030W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene GOS1/YHL031C.


ensembl_gene_id: YHL031C
symbol: GOS1
gene_biotype: protein_coding
description:
  Golgi SNAP receptor complex member 1; v-SNARE protein involved in Golgi transport; homolog of the mammalian protein GOS-28/GS28.


ensembl_gene_id: YHL032C
symbol: GUT1
gene_biotype: protein_coding
description:
  Glycerol kinase; converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p; Belongs to the FGGY kinase family.


ensembl_gene_id: YHL033C
symbol: RPL8A
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L8A; required for processing of 27SA3 pre-rRNA to 27SB pre-rRNA during assembly of large ribosomal subunit; depletion leads to a turnover of pre-rRNA; L8 binds to Domain I of 25S and 5.8 S rRNAs; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8A has a paralog, RPL8B, that arose from the whole genome duplication.


ensembl_gene_id: YHL034C
symbol: SBP1
gene_biotype: protein_coding
description:
  Single-stranded nucleic acid-binding protein; Protein that binds eIF4G and has a role in repression of translation; has an RGG motif; found in cytoplasmic P bodies; binds to mRNAs under glucose starvation stress, most often in the 5' UTR; found associated with small nucleolar RNAs snR10 and snR11; SBP1 has a paralog, RNP1, that arose from the whole genome duplication; Belongs to the RRM GAR family.


ensembl_gene_id: YHL034W-A
symbol: YHL034W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YHL034W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF SBP1/YHL034C.


ensembl_gene_id: YHL035C
symbol: VMR1
gene_biotype: protein_coding
description:
  ABC transporter ATP-binding protein/permease VMR1; Vacuolar membrane protein; involved in multiple drug resistance and metal sensitivity; ATP-binding cassette (ABC) family member involved in drug transport; potential Cdc28p substrate; induced under respiratory conditions; VMR1 has a paralog, YBT1, that arose from the whole genome duplication.


ensembl_gene_id: YHL037C
symbol: YHL037C
gene_biotype: protein_coding
description:
  Uncharacterized protein YHL037C; Putative protein of unknown function; conserved among S. cerevisiae strains.


ensembl_gene_id: YHL038C
symbol: CBP2
gene_biotype: protein_coding
description:
  Cytochrome B pre-mRNA-processing protein 2; Required for splicing of the group I intron bI5 of the COB pre-mRNA; nuclear-encoded mitochondrial protein that binds to the RNA to promote splicing; also involved in but not essential for splicing of the COB bI2 intron and the intron in the 21S rRNA gene.


ensembl_gene_id: YHL039W
symbol: EFM1
gene_biotype: protein_coding
description:
  Protein-lysine N-methyltransferase EFM1; Lysine methyltransferase; involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm.


ensembl_gene_id: YHL040C
symbol: ARN1
gene_biotype: protein_coding
description:
  ARN family transporter for siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores; protein increases in abundance and relocalizes to the vacuole upon DNA replication stress; Belongs to the major facilitator superfamily.


ensembl_gene_id: YHL041W
symbol: YHL041W
gene_biotype: protein_coding
description:
  Uncharacterized protein YHL041W; Putative protein of unknown function; conserved across S. cerevisiae strains.


ensembl_gene_id: YHL042W
symbol: YHL042W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YHL042W; Protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins; SWAT-GFP and mCherry fusion proteins localize to the vacuole.


ensembl_gene_id: YHL043W
symbol: ECM34
gene_biotype: protein_coding
description:
  Protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins; SWAT-GFP, seamless-GFP and mCherry C-terminal fusion proteins localize to the cytosol; Belongs to the DUP/COS family.


ensembl_gene_id: YHL044W
symbol: YHL044W
gene_biotype: protein_coding
description:
  DUP240 protein YHL044W; Putative integral membrane protein; member of DUP240 gene family; green fluorescent protein (GFP)-fusion protein localizes to the plasma membrane in a punctate pattern.


ensembl_gene_id: YHL046C
symbol: PAU13
gene_biotype: protein_coding
description:
  Seripauperin-13; Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expression is induced after ethanol shock; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively; Belongs to the SRP1/TIP1 family. Seripauperin subfamily.


ensembl_gene_id: YHL046W-A
symbol: YHL046W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YHL046W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF ARN2/YHL047C.


ensembl_gene_id: YHL047C
symbol: ARN2
gene_biotype: protein_coding
description:
  Siderophore iron transporter ARN2; Transporter; member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to the siderophore triacetylfusarinine C; Belongs to the major facilitator superfamily.


ensembl_gene_id: YHL048C-A
symbol: YHL048C-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YHL048C-A; Putative protein of unknown function; identified by expression profiling and mass spectrometry.


ensembl_gene_id: YHL048W
symbol: COS8
gene_biotype: protein_coding
description:
  Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins; Belongs to the DUP/COS family.


ensembl_gene_id: YHL050W-A
symbol: YHL050W-A
gene_biotype: protein_coding
description:
  Putative UPF0479 protein YHL050W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; Belongs to the UPF0479 family.


ensembl_gene_id: YHR001W
symbol: OSH7
gene_biotype: protein_coding
description:
  Oxysterol-binding protein; part of family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability; OSH7 has a paralog, OSH6, that arose from the whole genome duplication.


ensembl_gene_id: YHR001W-A
symbol: QCR10
gene_biotype: protein_coding
description:
  Subunit of the ubiqunol-cytochrome c oxidoreductase complex; this complex comprises part of the mitochondrial respiratory chain; members include Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p and comprises part of the mitochondrial respiratory chain; Belongs to the UQCR11/QCR10 family.


ensembl_gene_id: YHR002W
symbol: LEU5
gene_biotype: protein_coding
description:
  Mitochondrial carrier protein; involved in the accumulation of CoA in the mitochondrial matrix; homolog of human Graves disease protein SLC25A16, which complements yeast null mutant; does not encode an isozyme of Leu4p, as first hypothesized.


ensembl_gene_id: YHR003C
symbol: TCD1
gene_biotype: protein_coding
description:
  tRNA threonylcarbamoyladenosine dehydratase; required for the ct6A tRNA base modification, where an adenosine at position 37 is modified to form a cyclized active ester with an oxazolone ring; localized to the mitochondrial outer membrane; TCD1 has a paralog, TCD2, that arose from the whole genome duplication.


ensembl_gene_id: YHR004C
symbol: NEM1
gene_biotype: protein_coding
description:
  Nuclear envelope morphology protein 1; Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology and sporulation; homolog of the human protein Dullard; Belongs to the Dullard family.


ensembl_gene_id: YHR005C
symbol: GPA1
gene_biotype: protein_coding
description:
  Guanine nucleotide-binding protein alpha-1 subunit; Subunit of the G protein involved in pheromone response; GTP-binding alpha subunit of the heterotrimeric G protein; negatively regulates the mating pathway by sequestering G(beta)gamma and by triggering an adaptive response; activates Vps34p at the endosome; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YHR005C-A
symbol: TIM10
gene_biotype: protein_coding
description:
  Mitochondrial import inner membrane translocase subunit TIM10; Essential protein of the mitochondrial intermembrane space; forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner membrane.


ensembl_gene_id: YHR006W
symbol: STP2
gene_biotype: protein_coding
description:
  Transcription factor; activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes; STP2 has a paralog, STP1, that arose from the whole genome duplication.


ensembl_gene_id: YHR007C
symbol: ERG11
gene_biotype: protein_coding
description:
  Lanosterol 14-alpha-demethylase; catalyzes C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in ergosterol biosynthesis pathway; transcriptionally down-regulated when ergosterol is in excess; member of cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p; human CYP51A1 functionally complements the lethality of the erg11 null mutation.


ensembl_gene_id: YHR007C-A
symbol: YHR007C-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YHR007C-A; Putative protein of unknown function; identified by expression profiling and mass spectrometry; SWAT-GFP fusion protein localizes to the nucleus.


ensembl_gene_id: YHR008C
symbol: SOD2
gene_biotype: protein_coding
description:
  Mitochondrial manganese superoxide dismutase; protects cells against oxygen toxicity and oxidative stress; human mitochondrial SOD2 can complement a yeast null mutant and human cytoplasmic SOD1 can also complement when targeted to the mitochondrial matrix.


ensembl_gene_id: YHR009C
symbol: TDA3
gene_biotype: protein_coding
description:
  Putative oxidoreductase involved in late endosome to Golgi transport; physical and genetical interactions with Btn2p; null mutant is viable, has extended S phase, and sensitive to expression of top1-T722A allele; similar to human FOXRED1.


ensembl_gene_id: YHR010W
symbol: RPL27A
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L27A; homologous to mammalian ribosomal protein L27, no bacterial homolog; RPL27A has a paralog, RPL27B, that arose from the whole genome duplication.


ensembl_gene_id: YHR011W
symbol: DIA4
gene_biotype: protein_coding
description:
  Serine--tRNA ligase, mitochondrial; Probable mitochondrial seryl-tRNA synthetase; mutant displays increased invasive and pseudohyphal growth; Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.


ensembl_gene_id: YHR012W
symbol: VPS29
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 29; Subunit of the membrane-associated retromer complex; endosomal protein; essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval; Belongs to the VPS29 family.


ensembl_gene_id: YHR013C
symbol: ARD1
gene_biotype: protein_coding
description:
  Subunit of protein N-terminal acetyltransferase NatA; NatA comprises Nat1p, Ard1p, Nat5p; acetylates many proteins to influence telomeric silencing, cell cycle, heat-shock resistance, mating, sporulation, early stages of mitophagy; protein abundance increases under DNA replication stress; mutations in human homolog X-linked NAA10 lead to Ogden syndrome (S37P) and intellectual disability (R116W); expression of human NAA10 and NAA15 can complement ard1 nat1 double mutant.


ensembl_gene_id: YHR014W
symbol: SPO13
gene_biotype: protein_coding
description:
  Meiosis-specific protein SPO13; Meiotic regulator; involved in maintaining sister chromatid cohesion during meiosis I as well as promoting proper attachment of kinetochores to the spindle during meiosis I and meiosis II; anaphase-promoting complex (APC) substrate that is degraded during anaphase I; expressed only in meiotic cells.


ensembl_gene_id: YHR015W
symbol: MIP6
gene_biotype: protein_coding
description:
  Putative RNA-binding protein; interacts with Mex67p, which is a component of the nuclear pore involved in nuclear mRNA export; MIP6 has a paralog, PES4, that arose from the whole genome duplication.


ensembl_gene_id: YHR016C
symbol: YSC84
gene_biotype: protein_coding
description:
  Actin-binding protein; involved in bundling of actin filaments and endocytosis of actin cortical patches; activity stimulated by Las17p; contains SH3 domain similar to Rvs167p; YSC84 has a paralog, LSB3, that arose from the whole genome duplication.


ensembl_gene_id: YHR017W
symbol: YSC83
gene_biotype: protein_coding
description:
  UPF0744 protein YSC83; Non-essential mitochondrial protein of unknown function; mRNA induced during meiosis, peaking between mid to late prophase of meiosis I; similar to S. douglasii YSD83.


ensembl_gene_id: YHR018C
symbol: ARG4
gene_biotype: protein_coding
description:
  Argininosuccinate lyase; catalyzes the final step in the arginine biosynthesis pathway; Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.


ensembl_gene_id: YHR019C
symbol: DED81
gene_biotype: protein_coding
description:
  Asparagine--tRNA ligase, cytoplasmic; Cytosolic asparaginyl-tRNA synthetase; required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA; Belongs to the class-II aminoacyl-tRNA synthetase family.


ensembl_gene_id: YHR020W
symbol: YHR020W
gene_biotype: protein_coding
description:
  Putative proline--tRNA ligase YHR020W; Prolyl-tRNA synthetase; N-terminal domain shows weak homology to prokaryotic posttransfer editing domain, but does not possess posttransfer editing activity; may interact with ribosomes, based on co-purification experiments.


ensembl_gene_id: YHR021C
symbol: RPS27B
gene_biotype: protein_coding
description:
  Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S27, no bacterial homolog; RPS27B has a paralog, RPS27A, that arose from the whole genome duplication.


ensembl_gene_id: YHR021W-A
symbol: ECM12
gene_biotype: protein_coding
description:
  Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity.


ensembl_gene_id: YHR022C-A
symbol: YHR022C-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YHR022C-A; Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching.


ensembl_gene_id: YHR023W
symbol: MYO1
gene_biotype: protein_coding
description:
  Myosin-1; Type II myosin heavy chain; required for wild-type cytokinesis and cell separation; localizes to the actomyosin ring; binds to myosin light chains Mlc1p and Mlc2p through its IQ1 and IQ2 motifs respectively.


ensembl_gene_id: YHR024C
symbol: MAS2
gene_biotype: protein_coding
description:
  Alpha subunit of the mitochondrial processing protease (MPP); essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins.


ensembl_gene_id: YHR025W
symbol: THR1
gene_biotype: protein_coding
description:
  Homoserine kinase; conserved protein required for threonine biosynthesis; long-lived protein that is preferentially retained in mother cells and forms cytoplasmic filaments; expression is regulated by the GCN4-mediated general amino acid control pathway.


ensembl_gene_id: YHR026W
symbol: VMA16
gene_biotype: protein_coding
description:
  Subunit c'' of the vacuolar ATPase; v-ATPase functions in acidification of the vacuole; one of three proteolipid subunits of the V0 domain.


ensembl_gene_id: YHR027C
symbol: RPN1
gene_biotype: protein_coding
description:
  Non-ATPase base subunit of the 19S RP of the 26S proteasome; may participate in the recognition of several ligands of the proteasome; contains a leucine-rich repeat (LRR) domain, a site for protein-protein interactions; RP is the acronym for regulatory particle.


ensembl_gene_id: YHR028C
symbol: DAP2
gene_biotype: protein_coding
description:
  Dipeptidyl aminopeptidase; synthesized as a glycosylated precursor; localizes to the vacuolar membrane; similar to Ste13p.


ensembl_gene_id: YHR028W-A
symbol: YHR028W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YHR028W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF DAP2/YHR028C.


ensembl_gene_id: YHR029C
symbol: YHI9
gene_biotype: protein_coding
description:
  Uncharacterized isomerase YHI9; Protein of unknown function; null mutant is defective in unfolded protein response; possibly involved in a membrane regulation metabolic pathway; member of the PhzF superfamily, though most likely not involved in phenazine production.


ensembl_gene_id: YHR030C
symbol: SLT2
gene_biotype: protein_coding
description:
  Mitogen-activated protein kinase SLT2/MPK1; Serine/threonine MAP kinase; coordinates expression of all 19S regulatory particle assembly-chaperones (RACs) to control proteasome abundance; involved in regulating maintenance of cell wall integrity, cell cycle progression, nuclear mRNA retention in heat shock, septum assembly; required for mitophagy, pexophagy; affects recruitment of mitochondria to phagophore assembly site; plays role in adaptive response of cells to cold; regulated by the PKC1-mediated signaling pathway; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kin [...]


ensembl_gene_id: YHR031C
symbol: RRM3
gene_biotype: protein_coding
description:
  DNA helicase involved in rDNA replication and Ty1 transposition; binds to and suppresses DNA damage at G4 motifs in vivo; relieves replication fork pauses at telomeric regions; structurally and functionally related to Pif1p; Belongs to the helicase family.


ensembl_gene_id: YHR032C-A
symbol: YHR032C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YHR032C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YHR032W-A.


ensembl_gene_id: YHR032W
symbol: ERC1
gene_biotype: protein_coding
description:
  Ethionine resistance-conferring protein 1; Member of the multi-drug and toxin extrusion (MATE) family; the MATE family is part of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily; overproduction confers ethionine resistance and accumulation of S-adenosylmethionine.


ensembl_gene_id: YHR032W-A
symbol: YHR032W-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YHR032W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YHR032C-A.


ensembl_gene_id: YHR033W
symbol: YHR033W
gene_biotype: protein_coding
description:
  Uncharacterized protein YHR033W; Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; YHR033W has a paralog, PRO1, that arose from the whole genome duplication.


ensembl_gene_id: YHR034C
symbol: PIH1
gene_biotype: protein_coding
description:
  Protein interacting with Hsp90 1; Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly large protein complexes such as box C/D snoRNPs and RNA polymerase II.


ensembl_gene_id: YHR035W
symbol: NEL1
gene_biotype: protein_coding
description:
  GTPase-activating protein NEL1; Activator of Sar1p GTPase activity; paralog of Sec23 but does not associate with the COPII components; not an essential gene; Belongs to the SEC23/SEC24 family. SEC23 subfamily.


ensembl_gene_id: YHR036W
symbol: BRL1
gene_biotype: protein_coding
description:
  Nucleus export protein BRL1; Essential nuclear envelope/ER integral membrane protein; interacts and functions with Apq12p and Brr6p in lipid homeostasis; mutants are defective in nuclear pore complex biogenesis, mRNA nuclear export and are sensitive to sterol biosynthesis inhibitors and membrane fluidizing agents; identified as a dosage suppressor of a temperature sensitive mutation in the major karyopherin, CRM1; homologous to Brr6p; Belongs to the BRL1/BRR6 family.


ensembl_gene_id: YHR037W
symbol: PUT2
gene_biotype: protein_coding
description:
  Delta-1-pyrroline-5-carboxylate dehydrogenase; nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of human homolog ALDH4A1 causes type II hyperprolinemia (HPII), an autosomal recessive inborn error of metabolism; human homolog ALDH4A1 can complement yeast null mutant.


ensembl_gene_id: YHR038W
symbol: RRF1
gene_biotype: protein_coding
description:
  Ribosome-recycling factor, mitochondrial; Mitochondrial ribosome recycling factor; essential for mitochondrial protein synthesis and for the maintenance of the respiratory function of mitochondria.


ensembl_gene_id: YHR039C
symbol: MSC7
gene_biotype: protein_coding
description:
  Putative aldehyde dehydrogenase-like protein YHR039C; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; msc7 mutants are defective in directing meiotic recombination events to homologous chromatids.


ensembl_gene_id: YHR039C-A
symbol: VMA10
gene_biotype: protein_coding
description:
  Subunit G of the V1 peripheral membrane domain of V-ATPase; part of the electrogenic proton pump found throughout the endomembrane system; involved in vacuolar acidification; the V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase) has eight subunits.


ensembl_gene_id: YHR041C
symbol: SRB2
gene_biotype: protein_coding
description:
  Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; general transcription factor involved in telomere maintenance.


ensembl_gene_id: YHR042W
symbol: NCP1
gene_biotype: protein_coding
description:
  NADP-cytochrome P450 reductase; involved in ergosterol biosynthesis; associated and coordinately regulated with Erg11p; In the N-terminal section; belongs to the flavodoxin family.


ensembl_gene_id: YHR043C
symbol: DOG2
gene_biotype: protein_coding
description:
  2-deoxyglucose-6-phosphate phosphatase; member of a family of low molecular weight phosphatases, induced by oxidative and osmotic stress, confers 2-deoxyglucose resistance when overexpressed; DOG2 has a paralog, DOG1, that arose from a single-locus duplication; the last half of DOG1 and DOG2 are subject to gene conversions among S. cerevisiae, S. paradoxus, and S. mikatae.


ensembl_gene_id: YHR044C
symbol: DOG1
gene_biotype: protein_coding
description:
  2-deoxyglucose-6-phosphate phosphatase; member of a family of low molecular weight phosphatases; confers 2-deoxyglucose resistance when overexpressed; DOG1 has a paralog, DOG2, that arose from a single-locus duplication; the last half of DOG1 and DOG2 are subject to gene conversions among S. cerevisiae, S. paradoxus, and S. mikatae.


ensembl_gene_id: YHR045W
symbol: YHR045W
gene_biotype: protein_coding
description:
  Putative protein of unknown function; possible role in iron metabolism and/or amino acid and carbohydrate metabolism; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum.


ensembl_gene_id: YHR046C
symbol: INM1
gene_biotype: protein_coding
description:
  Inositol monophosphatase; involved in biosynthesis of inositol and in phosphoinositide second messenger signaling; INM1 expression increases in the presence of inositol and decreases upon exposure to antibipolar drugs lithium and valproate.


ensembl_gene_id: YHR047C
symbol: AAP1
gene_biotype: protein_coding
description:
  Alanine/arginine aminopeptidase; Arginine/alanine amino peptidase; overproduction stimulates glycogen accumulation; AAP1 has a paralog, APE2, that arose from the whole genome duplication.


ensembl_gene_id: YHR048W
symbol: YHK8
gene_biotype: protein_coding
description:
  Probable drug/proton antiporter YHK8; Presumed antiporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles.


ensembl_gene_id: YHR049C-A
symbol: YHR049C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YHR049C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YHR049W
symbol: FSH1
gene_biotype: protein_coding
description:
  Family of serine hydrolases 1; Putative serine hydrolase; localizes to both the nucleus and cytoplasm; sequence is similar to S. cerevisiae Fsh2p and Fsh3p and the human candidate tumor suppressor OVCA2.


ensembl_gene_id: YHR050W
symbol: SMF2
gene_biotype: protein_coding
description:
  Divalent metal ion transporter involved in manganese homeostasis; has broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins; Belongs to the NRAMP family.


ensembl_gene_id: YHR050W-A
symbol: YHR050W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YHR050W-A; Protein of unknown function; identified by expression profiling and mass spectrometry.


ensembl_gene_id: YHR051W
symbol: COX6
gene_biotype: protein_coding
description:
  Subunit VI of cytochrome c oxidase (Complex IV); Complex IV is the terminal member of the mitochondrial inner membrane electron transport chain; expression is regulated by oxygen levels.


ensembl_gene_id: YHR052W
symbol: CIC1
gene_biotype: protein_coding
description:
  Proteasome-interacting protein CIC1; Essential protein that interacts with proteasome components; has a potential role in proteasome substrate specificity; also copurifies with 66S pre-ribosomal particles.


ensembl_gene_id: YHR052W-A
symbol: YHR052W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YHR052W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps CUP1-1.


ensembl_gene_id: YHR053C
symbol: CUP1-1
gene_biotype: protein_coding
description:
  Metallothionein; binds copper and mediates resistance to high concentrations of copper and cadmium; locus is variably amplified in different strains, with two copies, CUP1-1 and CUP1-2, in the genomic sequence reference strain S288C; CUP1-1 has a paralog, CUP1-2, that arose from a segmental duplication.


ensembl_gene_id: YHR054C
symbol: YHR054C
gene_biotype: protein_coding
description:
  Uncharacterized protein YHR054C; Putative protein of unknown function; partial duplicate of RSC30/YHR056C, truncated remnant of segmental duplication; To yeast YHR056c.


ensembl_gene_id: YHR054W-A
symbol: YHR054W-A
gene_biotype: protein_coding
description:
  Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps CUP1-2.


ensembl_gene_id: YHR055C
symbol: CUP1-2
gene_biotype: protein_coding
description:
  Metallothionein; binds copper and mediates resistance to high concentrations of copper and cadmium; locus is variably amplified in different strains, with two copies, CUP1-1 and CUP1-2, in the genomic sequence reference strain S288C; CUP1-2 has a paralog, CUP1-1, that arose from a segmental duplication.


ensembl_gene_id: YHR056C
symbol: RSC30
gene_biotype: protein_coding
description:
  Chromatin structure-remodeling complex protein RSC30; Component of the RSC chromatin remodeling complex; non-essential gene required for regulation of ribosomal protein genes and the cell wall/stress response; null mutants are osmosensitive; RSC30 has a paralog, RSC3, that arose from the whole genome duplication.


ensembl_gene_id: YHR056W-A
symbol: YHR056W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized membrane protein YHR056W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps ORF RSC30/YHR056C.


ensembl_gene_id: YHR057C
symbol: CPR2
gene_biotype: protein_coding
description:
  Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; potential role in the secretory pathway; seamless-GFP and mCherry fusion proteins localize to the vacuole, while SWAT-GFP fusion localizes to both the endoplasmic reticulum and vacuole; suppresses toxicity of slow-folding human Z-type alpha1-antitrypsin variant associated with liver cirrhosis and emphysema.


ensembl_gene_id: YHR058C
symbol: MED6
gene_biotype: protein_coding
description:
  Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YHR059W
symbol: FYV4
gene_biotype: protein_coding
description:
  Protein FYV4, mitochondrial; Protein of unknown function; required for survival upon exposure to K1 killer toxin; Belongs to the mitochondrion-specific ribosomal protein mS41 family.


ensembl_gene_id: YHR060W
symbol: VMA22
gene_biotype: protein_coding
description:
  Protein that is required for vacuolar H+-ATPase (V-ATPase) function; peripheral membrane protein; not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER).


ensembl_gene_id: YHR061C
symbol: GIC1
gene_biotype: protein_coding
description:
  GTPase-interacting component 1; Protein involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain; relocalizes from bud neck to nucleus upon DNA replication stress; GIC1 has a paralog, GIC2, that arose from the whole genome duplication.


ensembl_gene_id: YHR062C
symbol: RPP1
gene_biotype: protein_coding
description:
  Ribonuclease P/MRP protein subunit RPP1; Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; relocalizes to the cytosol in response to hypoxia; Belongs to the eukaryotic/archaeal RNase P protein component 3 family.


ensembl_gene_id: YHR063C
symbol: PAN5
gene_biotype: protein_coding
description:
  2-dehydropantoate 2-reductase; part of the pantothenic acid pathway, structurally homologous to E. coli panE.


ensembl_gene_id: YHR063W-A
symbol: YHR063W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized membrane protein YHR063W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF SSZ1/YHR064C.


ensembl_gene_id: YHR064C
symbol: SSZ1
gene_biotype: protein_coding
description:
  Ribosome-associated complex subunit SSZ1; Hsp70 protein that interacts with Zuo1p (a DnaJ homolog); interacts with Zuo1p to form a ribosome-associated complex that binds the ribosome via the Zuo1p subunit; also involved in pleiotropic drug resistance via sequential activation of PDR1 and PDR5; binds ATP.


ensembl_gene_id: YHR065C
symbol: RRP3
gene_biotype: protein_coding
description:
  ATP-dependent rRNA helicase RRP3; Protein involved in rRNA processing; required for maturation of the 35S primary transcript of pre-rRNA and for cleavage leading to mature 18S rRNA; homologous to eIF-4a, which is a DEAD box RNA-dependent ATPase with helicase activity.


ensembl_gene_id: YHR066W
symbol: SSF1
gene_biotype: protein_coding
description:
  Ribosome biogenesis protein SSF1; Constituent of 66S pre-ribosomal particles; required for ribosomal large subunit maturation; functionally redundant with Ssf2p; member of the Brix family; SSF1 has a paralog, SSF2, that arose from the whole genome duplication.


ensembl_gene_id: YHR067W
symbol: HTD2
gene_biotype: protein_coding
description:
  Mitochondrial 3-hydroxyacyl-thioester dehydratase; involved in fatty acid biosynthesis, required for respiratory growth and for normal mitochondrial morphology.


ensembl_gene_id: YHR068W
symbol: DYS1
gene_biotype: protein_coding
description:
  Deoxyhypusine synthase; catalyzes formation of deoxyhypusine, the first step in hypusine biosynthesis; triggers posttranslational hypusination of translation elongation factor eIF-5A and regulates its intracellular levels; tetrameric; human homolog DHPS allows growth of yeast haploid dys1 null mutant after sporulation of heterozygous diploid.


ensembl_gene_id: YHR069C
symbol: RRP4
gene_biotype: protein_coding
description:
  Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain RNA binding domains; has similarity to human hRrp4p (EXOSC2).


ensembl_gene_id: YHR069C-A
symbol: YHR069C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized membrane protein YHR069C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps ORF TRM5/YHR070W.


ensembl_gene_id: YHR070C-A
symbol: YHR070C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YHR070C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene TRM5/YHR070W.


ensembl_gene_id: YHR070W
symbol: TRM5
gene_biotype: protein_coding
description:
  tRNA(m(1)G37)methyltransferase; methylates a tRNA base adjacent to the anticodon that has a role in prevention of frameshifting; localized to both cytoplasm and mitochondria, and modifies both cytoplasmic and mitochondrial tRNAs; mutations in human ortholog TRMT5 are associated with skeletal muscle respiratory chain deficiencies, and trm5 mutations analogous to disease mutations decrease respiration; Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.


ensembl_gene_id: YHR071C-A
symbol: YHR071C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YHR071C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF ERG7/YHR072W.


ensembl_gene_id: YHR071W
symbol: PCL5
gene_biotype: protein_coding
description:
  PHO85 cyclin-5; Cyclin; interacts with and phosphorylated by Pho85p cyclin-dependent kinase (Cdk), induced by Gcn4p at level of transcription, specifically required for Gcn4p degradation, may be sensor of cellular protein biosynthetic capacity; Belongs to the cyclin family. PCL1,2 subfamily.


ensembl_gene_id: YHR072W
symbol: ERG7
gene_biotype: protein_coding
description:
  Lanosterol synthase; an essential enzyme that catalyzes the cyclization of squalene 2,3-epoxide, a step in ergosterol biosynthesis; human LSS functionally complements the lethality of the erg7 null mutation; Belongs to the terpene cyclase/mutase family.


ensembl_gene_id: YHR073C-B
symbol: YHR073C-B
gene_biotype: protein_coding
description:
  Uncharacterized protein YHR073C-B; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified ORF YHR073W; identified by expression profiling and mass spectrometry.


ensembl_gene_id: YHR073W
symbol: OSH3
gene_biotype: protein_coding
description:
  Member of an oxysterol-binding protein family; this family has seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability; contains FFAT motif; interacts with ER anchor Scs2p at patches at the plasma membrane; regulated by sterol binding; Belongs to the OSBP family.


ensembl_gene_id: YHR073W-A
symbol: YHR073W-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YHR073W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified ORF YHR073W; identified by expression profiling and mass spectrometry.


ensembl_gene_id: YHR074W
symbol: QNS1
gene_biotype: protein_coding
description:
  Glutamine-dependent NAD(+) synthetase; essential for the formation of NAD(+) from nicotinic acid adenine dinucleotide.


ensembl_gene_id: YHR075C
symbol: PPE1
gene_biotype: protein_coding
description:
  Protein phosphatase methylesterase 1; Protein with carboxyl methyl esterase activity; may have a role in demethylation of the phosphoprotein phosphatase catalytic subunit; also identified as a small subunit mitochondrial ribosomal protein; Belongs to the AB hydrolase superfamily.


ensembl_gene_id: YHR076W
symbol: PTC7
gene_biotype: protein_coding
description:
  Type 2C serine/threonine protein phosphatase (PP2C); alternatively spliced to create two mRNA isoforms; protein from spliced form localizes to the mitochondria while the one from the unspliced form is localized to the nuclear envelope; activates coenzyme Q6 biosynthesis by dephosphorylation of demethoxy-Q6 hydroxylase Coq7p.


ensembl_gene_id: YHR077C
symbol: NMD2
gene_biotype: protein_coding
description:
  Protein involved in the nonsense-mediated mRNA decay (NMD) pathway; interacts with Nam7p and Upf3p; involved in telomere maintenance.


ensembl_gene_id: YHR079C
symbol: IRE1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase/endoribonuclease IRE1; Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; role in homeostatic adaptation to ER stress; Kar2p binds inactive Ire1p and releases from it upon ER stress.


ensembl_gene_id: YHR079C-A
symbol: SAE3
gene_biotype: protein_coding
description:
  Pachytene arrest protein SAE3; Meiosis-specific protein involved in meiotic recombination; involved in DMC1-dependent meiotic recombination; forms heterodimer with Mei5p; proposed to be an assembly factor for Dmc1p.


ensembl_gene_id: YHR080C
symbol: LAM4
gene_biotype: protein_coding
description:
  Membrane-anchored lipid-binding protein LAM4; Sterol-binding protein that localizes to puncta in the cortical ER; sterol binding occurs via two StART-like domains; one of six StART-like domain-containing proteins in yeast that may be involved in intracellular sterol transfer between membranes; conserved across eukaryotes; has both GRAM and StART-like (VASt) domains; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies.


ensembl_gene_id: YHR081W
symbol: LRP1
gene_biotype: protein_coding
description:
  Nuclear exosome-associated nucleic acid binding protein; involved in RNA processing, surveillance, degradation, tethering, and export; forms a stable heterodimer with Rrp6p and regulates its exonucleolytic activity; rapidly degraded by the proteasome in the absence of Rrp6p; homolog of mammalian nuclear matrix protein C1D involved in regulation of DNA repair and recombination.


ensembl_gene_id: YHR082C
symbol: KSP1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase KSP1; Serine/threonine protein kinase; associates with TORC1 and likely involved in TOR signaling cascades; negative regulator of autophagy; nuclear translocation required for haploid filamentous growth; regulates filamentous growth induced nuclear translocation of Bcy1p, Fus3p, and Sks1p; overproduction causes allele-specific suppression of prp20-10; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YHR083W
symbol: SAM35
gene_biotype: protein_coding
description:
  Component of the sorting and assembly machinery (SAM) complex; the SAM (or TOB) complex is located in the mitochondrial outer membrane; the complex binds precursors of beta-barrel proteins and facilitates their insertion into the outer membrane.


ensembl_gene_id: YHR084W
symbol: STE12
gene_biotype: protein_coding
description:
  Protein STE12; Transcription factor that is activated by a MAPK signaling cascade; activates genes involved in mating or pseudohyphal/invasive growth pathways; cooperates with Tec1p transcription factor to regulate genes specific for invasive growth.


ensembl_gene_id: YHR085W
symbol: IPI1
gene_biotype: protein_coding
description:
  Pre-rRNA-processing protein IPI1; Component of the Rix1 complex and possibly pre-replicative complexes; required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-replicative complex (pre-RC) formation and maintenance during DNA replication licensing; relocalizes to the cytosol in response to hypoxia; essential gene; Belongs to the IPI1/TEX10 family.


ensembl_gene_id: YHR086W
symbol: NAM8
gene_biotype: protein_coding
description:
  RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of REC107 pre-mRNA; Nam8p regulon embraces the meiotic pre-mRNAs of REC107, HFM1, AMA1 SPO22 and PCH2; the putative RNA binding domains RRM2 and RRM3 are required for Nam8p meiotic function.


ensembl_gene_id: YHR086W-A
symbol: YHR086W-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YHR086W-A; Putative protein of unknown function; identified by fungal homology and RT-PCR; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively.


ensembl_gene_id: YHR087W
symbol: RTC3
gene_biotype: protein_coding
description:
  Restriction of telomere capping protein 3; Protein of unknown function involved in RNA metabolism; has structural similarity to SBDS, the human protein mutated in Shwachman-Diamond Syndrome (the yeast SBDS ortholog = SDO1); null mutation suppresses cdc13-1 temperature sensitivity; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YHR088W
symbol: RPF1
gene_biotype: protein_coding
description:
  Ribosome production factor 1; Protein involved in assembly and export of the large ribosomal subunit; nucleolar protein; constituent of 66S pre-ribosomal particles; contains a sigma(70)-like motif, which is thought to bind RNA.


ensembl_gene_id: YHR089C
symbol: GAR1
gene_biotype: protein_coding
description:
  H/ACA ribonucleoprotein complex subunit GAR1; Protein component of the H/ACA snoRNP pseudouridylase complex; involved in the modification and cleavage of the 18S pre-rRNA; Belongs to the GAR1 family.


ensembl_gene_id: YHR090C
symbol: YNG2
gene_biotype: protein_coding
description:
  Chromatin modification-related protein YNG2; Subunit of NuA4, an essential histone acetyltransferase complex; positions Piccolo NuA4 for efficient acetylation of histone H4 or histone H2A; relocalizes to the cytosol in response to hypoxia; similar to human tumor suppressor ING1 and its isoforms ING4 and ING5.


ensembl_gene_id: YHR091C
symbol: MSR1
gene_biotype: protein_coding
description:
  Arginine--tRNA ligase, mitochondrial; Mitochondrial arginyl-tRNA synthetase; mutations in human ortholog are associated with pontocerebellar hypoplasia type 6; MSR1 has a paralog, YDR341C, that arose from the whole genome duplication; Belongs to the class-I aminoacyl-tRNA synthetase family.


ensembl_gene_id: YHR092C
symbol: HXT4
gene_biotype: protein_coding
description:
  High-affinity glucose transporter; member of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose; HXT4 has a paralog, HXT7, that arose from the whole genome duplication.


ensembl_gene_id: YHR093W
symbol: AHT1
gene_biotype: protein_coding
description:
  Hexose transport activator protein; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; multicopy suppressor of glucose transport defects, likely due to the presence of an HXT4 regulatory element in the region.


ensembl_gene_id: YHR094C
symbol: HXT1
gene_biotype: protein_coding
description:
  Low-affinity glucose transporter of the major facilitator superfamily; expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting; HXT1 has a paralog, HXT6, what arose from the whole genome duplication; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.


ensembl_gene_id: YHR095W
symbol: YHR095W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YHR095W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YHR096C
symbol: HXT5
gene_biotype: protein_coding
description:
  Hexose transporter with moderate affinity for glucose; induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs; HXT5 has a paralog, HXT3, that arose from the whole genome duplication.


ensembl_gene_id: YHR097C
symbol: YHR097C
gene_biotype: protein_coding
description:
  Uncharacterized protein YHR097C; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; YHR097C has a paralog, PAL1, that arose from the whole genome duplication.


ensembl_gene_id: YHR098C
symbol: SFB3
gene_biotype: protein_coding
description:
  SED5-binding protein 3; Component of the Sec23p-Sfb3p heterodimer of the COPII vesicle coat; COPII coat is required for cargo selection during vesicle formation in ER to Golgi transport; scaffolding function of Lst1p required to generate vesicles that can accommodate difficult cargo proteins that include large oligomeric assemblies and asymmetrically distributed membrane proteins; homologous to Sec24p and Sfb2p; Belongs to the SEC23/SEC24 family. SEC24 subfamily.


ensembl_gene_id: YHR099W
symbol: TRA1
gene_biotype: protein_coding
description:
  Transcription-associated protein 1; Subunit of SAGA and NuA4 histone acetyltransferase complexes; interacts with acidic activators (e.g., Gal4p) which leads to transcription activation; similar to human TRRAP, which is a cofactor for c-Myc mediated oncogenic transformation; Belongs to the PI3/PI4-kinase family. TRA1 subfamily.


ensembl_gene_id: YHR100C
symbol: GEP4
gene_biotype: protein_coding
description:
  Mitochondrial phosphatidylglycerophosphatase (PGP phosphatase); dephosphorylates phosphatidylglycerolphosphate to generate phosphatidylglycerol, an essential step during cardiolipin biosynthesis; null mutant is sensitive to tunicamycin, DTT; Belongs to the GEP4 family.


ensembl_gene_id: YHR101C
symbol: BIG1
gene_biotype: protein_coding
description:
  Protein BIG1; Integral membrane protein of the endoplasmic reticulum; required for normal content of cell wall beta-1,6-glucan; Belongs to the BIG1 family.


ensembl_gene_id: YHR102W
symbol: KIC1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase KIC1; Protein kinase of the PAK/Ste20 family, required for cell integrity; physically interacts with Cdc31p (centrin), which is a component of the spindle pole body; part of the RAM network that regulates cellular polarity and morphogenesis.


ensembl_gene_id: YHR103W
symbol: SBE22
gene_biotype: protein_coding
description:
  Protein involved in bud growth; involved in the transport of cell wall components from the Golgi to the cell surface; similar in structure and functionally redundant with Sbe2p; SBE22 has a paralog, SBE2, that arose from the whole genome duplication.


ensembl_gene_id: YHR104W
symbol: GRE3
gene_biotype: protein_coding
description:
  Aldose reductase; involved in methylglyoxal, d-xylose, arabinose, and galactose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by the HOG pathway; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YHR105W
symbol: YPT35
gene_biotype: protein_coding
description:
  Endosomal protein of unknown function; contains a phox (PX) homology domain; binds to both phosphatidylinositol-3-phosphate (PtdIns(3)P) and proteins involved in ER-Golgi or vesicular transport; Belongs to the YPT35 family.


ensembl_gene_id: YHR106W
symbol: TRR2
gene_biotype: protein_coding
description:
  Mitochondrial thioredoxin reductase; involved in protection against oxidative stress, required with Glr1p to maintain the redox state of Trx3p; contains active-site motif (CAVC) present in prokaryotic orthologs; binds NADPH and FAD; TRR2 has a paralog, TRR1, that arose from the whole genome duplication.


ensembl_gene_id: YHR107C
symbol: CDC12
gene_biotype: protein_coding
description:
  Cell division control protein 12; Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells.


ensembl_gene_id: YHR108W
symbol: GGA2
gene_biotype: protein_coding
description:
  ADP-ribosylation factor-binding protein GGA2; Protein that regulates Arf1p, Arf2p to facilitate Golgi trafficking; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin; GGA2 has a paralog, GGA1, that arose from the whole genome duplication.


ensembl_gene_id: YHR109W
symbol: CTM1
gene_biotype: protein_coding
description:
  Cytochrome c lysine methyltransferase; trimethylates residue 72 of apo-cytochrome c (Cyc1p) in the cytosol; not required for normal respiratory growth.


ensembl_gene_id: YHR111W
symbol: UBA4
gene_biotype: protein_coding
description:
  Adenylyltransferase and sulfurtransferase UBA4; E1-like protein that activates Urm1p before urmylation; also acts in thiolation of the wobble base of cytoplasmic tRNAs by adenylating and then thiolating Urm1p; receives sulfur from Tum1p; In the N-terminal section; belongs to the HesA/MoeB/ThiF family. UBA4 subfamily.


ensembl_gene_id: YHR112C
symbol: YHR112C
gene_biotype: protein_coding
description:
  Uncharacterized trans-sulfuration enzyme YHR112C; Protein of unknown function; localizes to the cytoplasm and nucleus; overexpression affects protein trafficking through the endocytic pathway; Belongs to the trans-sulfuration enzymes family.


ensembl_gene_id: YHR113W
symbol: APE4
gene_biotype: protein_coding
description:
  Cytoplasmic aspartyl aminopeptidase with possible vacuole function; Cvt pathway cargo protein; cleaves unblocked N-terminal acidic amino acids from peptide substrates; forms a 12-subunit homo-oligomer; M18 metalloprotease family.


ensembl_gene_id: YHR114W
symbol: BZZ1
gene_biotype: protein_coding
description:
  SH3 domain protein implicated in regulating actin polymerization; able to recruit actin polymerization machinery through its SH3 domains; colocalizes with cortical actin patches and Las17p; interacts with type I myosins.


ensembl_gene_id: YHR115C
symbol: DMA1
gene_biotype: protein_coding
description:
  Ubiquitin-protein ligase (E3); controls septin dynamics, spindle position checkpoint (SPOC) with ligase Dma2p by regulating recruitment of Elm1p to bud neck; regulates levels of eIF2 subunit Gcd11p, as well as abundance, localization, and ubiquitination of Cdk inhibitory kinase Swe1p; ubiquitinates cyclin Pcl1p; ortholog of human RNF8, similar to human Chfr; contains FHA, RING fingers; DMA1 has a paralog, DMA2, that arose from the whole genome duplication.


ensembl_gene_id: YHR116W
symbol: COX23
gene_biotype: protein_coding
description:
  Cytochrome c oxidase-assembly factor COX23, mitochondrial; Protein that functions in mitochondrial copper homeostasis; mitochondrial intermembrane space protein; essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs.


ensembl_gene_id: YHR117W
symbol: TOM71
gene_biotype: protein_coding
description:
  Protein TOM71; Mitochondrial outer membrane protein; probable minor component of the TOM (translocase of outer membrane) complex responsible for recognition and import of mitochondrially directed proteins; TOM71 has a paralog, TOM70, that arose from the whole genome duplication.


ensembl_gene_id: YHR118C
symbol: ORC6
gene_biotype: protein_coding
description:
  Subunit of the origin recognition complex (ORC); ORC directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; phosphorylated by Cdc28p; mutation in the human Orc6p is linked to Meier-Gorlin syndrome.


ensembl_gene_id: YHR119W
symbol: SET1
gene_biotype: protein_coding
description:
  Histone-lysine N-methyltransferase, H3 lysine-4 specific; Histone methyltransferase, subunit of the COMPASS (Set1C) complex; COMPASS methylates histone H3K4; Set1p-dependent H3K4 trimethylation recruits Nrd1p, allowing efficient termination of snoRNAs and cryptic unstable transcripts (CUTs) by Nrd1p-Nab3p-Sen1p pathway; modulates histone acetylation levels in promoter proximal regions to ensure efficient Nrd1p-dependent termination; required in transcriptional silencing near telomeres and at silent mating type loci; has a SET domain; Belongs to the class V-like SAM-binding methyltransf [...]


ensembl_gene_id: YHR120W
symbol: MSH1
gene_biotype: protein_coding
description:
  DNA-binding protein of the mitochondria; involved in repair of mitochondrial DNA; has ATPase activity and binds to DNA mismatches; has homology to E. coli MutS; transcription is induced during meiosis.


ensembl_gene_id: YHR121W
symbol: LSM12
gene_biotype: protein_coding
description:
  Protein of unknown function that may function in RNA processing; interacts with Pbp1p and Pbp4p and associates with ribosomes; contains an RNA-binding LSM domain and an AD domain; GFP-fusion protein is induced by the DNA-damaging agent MMS; relative distribution to the nucleus increases upon DNA replication stress; Belongs to the LSM12 family.


ensembl_gene_id: YHR122W
symbol: CIA2
gene_biotype: protein_coding
description:
  MIP18 family protein YHR122W; Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Met18p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; ortholog of human FAM96B.


ensembl_gene_id: YHR123W
symbol: EPT1
gene_biotype: protein_coding
description:
  Sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase; not essential for viability; EPT1 has a paralog, CPT1, that arose from the whole genome duplication.


ensembl_gene_id: YHR124W
symbol: NDT80
gene_biotype: protein_coding
description:
  Meiosis-specific transcription factor; required for exit from pachytene and for full meiotic recombination; activates middle sporulation genes; competes with Sum1p for binding to promoters containing middle sporulation elements (MSE).


ensembl_gene_id: YHR125W
symbol: YHR125W
gene_biotype: protein_coding
description:
  Uncharacterized protein YHR125W; Putative protein of unknown function; conserved across S. cerevisiae strains.


ensembl_gene_id: YHR126C
symbol: ANS1
gene_biotype: protein_coding
description:
  Probable GPI-anchored protein ANS1; Putative GPI protein; SWAT-GFP and mCherry fusion proteins localize to the vacuole; transcription dependent upon Azf1p.


ensembl_gene_id: YHR127W
symbol: YHR127W
gene_biotype: protein_coding
description:
  Uncharacterized protein YHR127W; Protein of unknown function; localizes to the nucleus; required for asymmetric localization of Kar9p during mitosis.


ensembl_gene_id: YHR128W
symbol: FUR1
gene_biotype: protein_coding
description:
  Uracil phosphoribosyltransferase; synthesizes UMP from uracil; involved in the pyrimidine salvage pathway.


ensembl_gene_id: YHR129C
symbol: ARP1
gene_biotype: protein_coding
description:
  Centractin; Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; forms actin-like short filament composed of 9 or 10 Arp1p monomers; putative ortholog of mammalian centractin.


ensembl_gene_id: YHR130C
symbol: YHR130C
gene_biotype: protein_coding
description:
  Uncharacterized protein YHR130C; Putative protein of unknown function; conserved among S. cerevisiae strains; YHR130C is not an essential gene.


ensembl_gene_id: YHR131C
symbol: YHR131C
gene_biotype: protein_coding
description:
  PH domain-containing protein YHR131C; Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; overexpression causes cell cycle delay or arrest; contains a PH domain and binds phosphatidylinositols and other lipids in a large-scale study; YHR131C has a paralog, YNL144C, that arose from the whole genome duplication.


ensembl_gene_id: YHR131W-A
symbol: YHR131W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YHR131W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YHR131C.


ensembl_gene_id: YHR132C
symbol: ECM14
gene_biotype: protein_coding
description:
  Putative metallocarboxypeptidase ECM14; Putative metalloprotease with similarity to zinc carboxypeptidases; required for normal cell wall assembly; Belongs to the peptidase M14 family.


ensembl_gene_id: YHR132W-A
symbol: IGO2
gene_biotype: protein_coding
description:
  mRNA stability protein IGO2; Protein required for initiation of G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylated by Rim15p; GFP protein localizes to the cytoplasm and nucleus; IGO2 has a paralog, IGO1, that arose from the whole genome duplication; Belongs to the endosulfine family.


ensembl_gene_id: YHR133C
symbol: NSG1
gene_biotype: protein_coding
description:
  Protein involved in regulation of sterol biosynthesis; specifically stabilizes Hmg2p, one of two HMG-CoA isoenzymes that catalyze the rate-limiting step in sterol biosynthesis; forms foci at the nuclear periphery upon DNA replication stress; relocalizes to the cytosol in response to hypoxia; homolog of mammalian INSIG proteins; NSG1 has a paralog, NSG2, that arose from the whole genome duplication.


ensembl_gene_id: YHR134W
symbol: WSS1
gene_biotype: protein_coding
description:
  DNA-dependent metalloprotease WSS1; SUMO-ligase and SUMO-targeted metalloprotease; involved in DNA repair; removes DNA-protein crosslinks at stalled replication forks during replication of damaged DNA; clears chromatin-bound sumoylated proteins; localizes to single spot on nuclear periphery of mother cells but not daughters; exhibits vacuolar localization upon genotoxic stress; activated by DNA binding; member of minigluzincins protease family with mammalian DVC1/Spartan; Belongs to the peptidase M3 family. WSS1-like metalloprotease (WLM) subfamily.


ensembl_gene_id: YHR135C
symbol: YCK1
gene_biotype: protein_coding
description:
  Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform; shares redundant functions with Yck2p in morphogenesis, proper septin assembly, endocytic trafficking, and glucose sensing; stabilized by Sod1p binding in the presence of glucose and oxygen, causing glucose repression of respiratory metabolism; involved in the phosphorylation and regulation of glucose sensor Rgt2p; YCK1 has a paralog, YCK2, that arose from the whole genome duplication.


ensembl_gene_id: YHR136C
symbol: SPL2
gene_biotype: protein_coding
description:
  Protein with similarity to cyclin-dependent kinase inhibitors; downregulates low-affinity phosphate transport during phosphate limitation by targeting Pho87p to the vacuole; upstream region harbors putative hypoxia response element (HRE) cluster; overproduction suppresses a plc1 null mutation; promoter shows an increase in Snf2p occupancy after heat shock; GFP-fusion protein localizes to the cytoplasm.


ensembl_gene_id: YHR137C-A
symbol: YHR137C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YHR137C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps verified gene ARO9/YHR137W; identified by gene-trapping, expression analysis, and genome-wide homology searching.


ensembl_gene_id: YHR137W
symbol: ARO9
gene_biotype: protein_coding
description:
  Aromatic aminotransferase II; catalyzes the first step of tryptophan, phenylalanine, and tyrosine catabolism; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.


ensembl_gene_id: YHR138C
symbol: YHR138C
gene_biotype: protein_coding
description:
  Uncharacterized protein YHR138C; Protein of unknown function; similar to Pbi2p; double null mutant lacking Pbi2p and Yhr138cp exhibits highly fragmented vacuoles; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YHR139C
symbol: SPS100
gene_biotype: protein_coding
description:
  Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall; expression also induced in cells treated with the mycotoxin patulin; SPS100 has a paralog, YGP1, that arose from the whole genome duplication.


ensembl_gene_id: YHR139C-A
symbol: YHR139C-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YHR139C-A; Putative protein of unknown function; conserved across S. cerevisiae strains.


ensembl_gene_id: YHR141C
symbol: RPL42B
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L42B; required for propagation of the killer toxin-encoding M1 double-stranded RNA satellite of the L-A double-stranded RNA virus; homologous to mammalian ribosomal protein L36A, no bacterial homolog; RPL42B has a paralog, RPL42A, that arose from the whole genome duplication.


ensembl_gene_id: YHR142W
symbol: CHS7
gene_biotype: protein_coding
description:
  Chitin synthase export chaperone; Protein of unknown function; may be involved in chitin biosynthesis by regulation of Chs3p export from the ER; relocalizes from bud neck to ER upon DNA replication stress.


ensembl_gene_id: YHR143W
symbol: DSE2
gene_biotype: protein_coding
description:
  Protein DSE2; Daughter cell-specific secreted protein with similarity to glucanases; degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP.


ensembl_gene_id: YHR143W-A
symbol: RPC10
gene_biotype: protein_coding
description:
  RNA polymerase subunit ABC10-alpha, found in RNA pol I, II, and III; relocalizes from nucleolus to cytoplasm upon DNA replication stress.


ensembl_gene_id: YHR144C
symbol: DCD1
gene_biotype: protein_coding
description:
  Deoxycytidine monophosphate (dCMP) deaminase; involved in dUMP and dTMP biosynthesis; expression is NOT cell cycle regulated.


ensembl_gene_id: YHR145C
symbol: YHR145C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YHR145C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YHR146W
symbol: CRP1
gene_biotype: protein_coding
description:
  Protein that binds to cruciform DNA structures; CRP1 has a paralog, MDG1, that arose from the whole genome duplication.


ensembl_gene_id: YHR148W
symbol: IMP3
gene_biotype: protein_coding
description:
  U3 small nucleolar ribonucleoprotein protein IMP3; Component of the SSU processome; SSU processome is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA; Belongs to the universal ribosomal protein uS4 family.


ensembl_gene_id: YHR149C
symbol: SKG6
gene_biotype: protein_coding
description:
  Protein SKG6; Integral membrane protein; localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p; SKG6 has a paralog, TOS2, that arose from the whole genome duplication.


ensembl_gene_id: YHR150W
symbol: PEX28
gene_biotype: protein_coding
description:
  Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; Belongs to the peroxin-2832 family. Peroxin-28 subfamily.


ensembl_gene_id: YHR151C
symbol: MTC6
gene_biotype: protein_coding
description:
  Protein of unknown function; mtc6 is synthetically sick with cdc13-1; SWAT-GFP and mCherry fusion proteins localize to the vacuole while SWAT-GFP fusion also localizes to the endoplasmic reticulum.


ensembl_gene_id: YHR152W
symbol: SPO12
gene_biotype: protein_coding
description:
  Sporulation-specific protein 12; Nucleolar protein of unknown function; positive regulator of mitotic exit; involved in regulating release of Cdc14p from the nucleolus in early anaphase, may play similar role in meiosis; SPO12 has a paralog, BNS1, that arose from the whole genome duplication.


ensembl_gene_id: YHR153C
symbol: SPO16
gene_biotype: protein_coding
description:
  Sporulation-specific protein 16; Meiosis-specific protein involved in synaptonemal complex assembly; implicated in regulation of crossover formation; required for sporulation.


ensembl_gene_id: YHR154W
symbol: RTT107
gene_biotype: protein_coding
description:
  Regulator of Ty1 transposition protein 107; Protein implicated in Mms22-dependent DNA repair during S phase; involved in recruiting the SMC5/6 complex to double-strand breaks; DNA damage induces phosphorylation by Mec1p at one or more SQ/TQ motifs; interacts with Mms22p and Slx4p; has four BRCT domains; has a role in regulation of Ty1 transposition; relative distribution to nuclear foci increases upon DNA replication stress.


ensembl_gene_id: YHR155W
symbol: LAM1
gene_biotype: protein_coding
description:
  Membrane-anchored lipid-binding protein LAM1; Putative sterol transfer protein; localizes to puncta in the cortical ER; probable role in retrograde transport of sterols from the plasma membrane to the ER; one of six StART-like domain-containing proteins in yeast that may be involved in sterol transfer between intracellular membranes; conserved across eukaryotes; contains GRAM, StART-like (VASt) and two PH-like domains; Belongs to the SIP3 family.


ensembl_gene_id: YHR156C
symbol: LIN1
gene_biotype: protein_coding
description:
  Protein LIN1; Non-essential component of U5 snRNP; nuclear protein; physically interacts with Irr1p of cohesin complex; may link together proteins involved in chromosome segregation, mRNA splicing and DNA replication.


ensembl_gene_id: YHR157W
symbol: REC104
gene_biotype: protein_coding
description:
  Protein involved in early stages of meiotic recombination; required for meiotic crossing over; forms a complex with Rec102p and Spo11p necessary during the initiation of recombination.


ensembl_gene_id: YHR158C
symbol: KEL1
gene_biotype: protein_coding
description:
  Kelch repeat-containing protein 1; Protein required for proper cell fusion and cell morphology; forms a complex with Bud14p and Kel2p that regulates Bnr1p (formin) to affect actin cable assembly, cytokinesis, and polarized growth; functions in a complex with Kel2p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate.


ensembl_gene_id: YHR159W
symbol: TDA11
gene_biotype: protein_coding
description:
  Topoisomerase I damage affected protein 11; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; potential Cdc28p substrate; null mutant is sensitive to expression of the top1-T722A allele.


ensembl_gene_id: YHR160C
symbol: PEX18
gene_biotype: protein_coding
description:
  Peroxin; required for targeting of peroxisomal matrix proteins containing PTS2; interacts with Pex7p; partially redundant with Pex21p; primarily responsible for peroxisomal import during growth on oleate, and expression is induced during oleate growth.


ensembl_gene_id: YHR161C
symbol: YAP1801
gene_biotype: protein_coding
description:
  Protein of the AP180 family, involved in clathrin cage assembly; binds Pan1p and clathrin; YAP1801 has a paralog, YAP1802, that arose from the whole genome duplication.


ensembl_gene_id: YHR162W
symbol: MPC2
gene_biotype: protein_coding
description:
  Highly conserved subunit of the mitochondrial pyruvate carrier (MPC); expressed during growth on fermentable carbon sources, and heterodimerizes with Mpc1p to form the fermentative isoform of MPC; MPC localizes to the mitochondrial inner membrane and mediates pyruvate uptake; MPC2 paralog, MPC3, heterodimerizes with Mpc1p to form the respiratory MPC isoform.


ensembl_gene_id: YHR163W
symbol: SOL3
gene_biotype: protein_coding
description:
  6-phosphogluconolactonase; catalyzes the second step of the pentose phosphate pathway; weak multicopy suppressor of los1-1 mutation; homologous to Sol2p and Sol1p; SOL3 has a paralog, SOL4, that arose from the whole genome duplication.


ensembl_gene_id: YHR164C
symbol: DNA2
gene_biotype: protein_coding
description:
  Tripartite DNA replication factor; single-stranded DNA-dependent ATPase, ATP-dependent nuclease, helicase; tracking protein for flap cleavage during Okazaki fragment maturation; involved in DNA repair/processing of meiotic DNA double strand breaks; component of telomeric chromatin with cell-cycle dependent localization; required for telomerase-dependent telomere synthesis; forms nuclear foci upon DNA replication stress; human homolog DNA2 complements yeast dna2 mutant.


ensembl_gene_id: YHR165C
symbol: PRP8
gene_biotype: protein_coding
description:
  Pre-mRNA-splicing factor 8; Component of U4/U6-U5 snRNP complex; involved in second catalytic step of splicing; participates in spliceosomal assembly through its interaction with U1 snRNA; largest and most evolutionarily conserved protein of the spliceosome; mutations in human ortholog, PRPF8, cause Retinitis pigmentosa and missplicing in Myelodysplastic syndrome; mouse ortholog interacts with androgen receptor and may have a role in prostate cancer.


ensembl_gene_id: YHR165W-A
symbol: YHR165W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YHR165W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps ORF PRP8/YHR165C.


ensembl_gene_id: YHR167W
symbol: THP2
gene_biotype: protein_coding
description:
  Subunit of the THO and TREX complexes; THO connects transcription elongation and mitotic recombination, and TREX is recruited to activated genes and couples transcription to mRNA export; involved in telomere maintenance.


ensembl_gene_id: YHR168W
symbol: MTG2
gene_biotype: protein_coding
description:
  GTPase MTG2, mitochondrial; Putative GTPase; member of the Obg family; peripheral protein of the mitochondrial inner membrane that associates with the large ribosomal subunit; required for mitochondrial translation, possibly via a role in ribosome assembly; Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.


ensembl_gene_id: YHR169W
symbol: DBP8
gene_biotype: protein_coding
description:
  ATPase, putative RNA helicase of the DEAD-box family; component of 90S preribosome complex involved in production of 18S rRNA and assembly of 40S small ribosomal subunit; ATPase activity stimulated by association with Esf2p; Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily.


ensembl_gene_id: YHR170W
symbol: NMD3
gene_biotype: protein_coding
description:
  Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex; Belongs to the NMD3 family.


ensembl_gene_id: YHR171W
symbol: ATG7
gene_biotype: protein_coding
description:
  Ubiquitin-like modifier-activating enzyme ATG7; Autophagy-related protein and dual specificity member of the E1 family; mediates the attachment of Atg12p to Atg5p and Atg8p to phosphatidylethanolamine which are required steps in autophagosome formation; E1 enzymes are also known as ubiquitin-activating enzymes; involved in methionine restriction extension of chronological lifespan in an autophagy-dependent manner; Belongs to the ATG7 family.


ensembl_gene_id: YHR172W
symbol: SPC97
gene_biotype: protein_coding
description:
  Spindle pole body component SPC97; Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque.


ensembl_gene_id: YHR173C
symbol: YHR173C
gene_biotype: protein_coding
description:
  Uncharacterized protein YHR173C; Protein of unknown function; expressed at both mRNA and protein levels; SWAT-GFP and mCherry fusion proteins localize to the vacuole.


ensembl_gene_id: YHR174W
symbol: ENO2
gene_biotype: protein_coding
description:
  Enolase II, a phosphopyruvate hydratase; catalyzes conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression induced in response to glucose; ENO2 has a paralog, ENO1, that arose from the whole genome duplication.


ensembl_gene_id: YHR175W
symbol: CTR2
gene_biotype: protein_coding
description:
  Low-affinity copper transporter of the vacuolar membrane; mutation confers resistance to toxic copper concentrations, while overexpression confers resistance to copper starvation; regulated by nonsense-mediated mRNA decay pathway.


ensembl_gene_id: YHR175W-A
symbol: YHR175W-A
gene_biotype: protein_coding
description:
  Uncharacterized membrane protein YHR175W-A; Putative protein of unknown function; identified by fungal homology and RT-PCR.


ensembl_gene_id: YHR176W
symbol: FMO1
gene_biotype: protein_coding
description:
  Flavin-containing monooxygenase; localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins.


ensembl_gene_id: YHR177W
symbol: YHR177W
gene_biotype: protein_coding
description:
  Uncharacterized protein YHR177W; Putative transcription factor containing a WOPR domain; binds DNA in vitro; similar to C. albicans Wor1p transcription factor that regulates white-opaque switching; overexpression causes a cell cycle delay or arrest.


ensembl_gene_id: YHR178W
symbol: STB5
gene_biotype: protein_coding
description:
  Protein STB5; Transcription factor; involved in regulating multidrug resistance and oxidative stress response; forms a heterodimer with Pdr1p; contains a Zn(II)2Cys6 zinc finger domain that interacts with a pleiotropic drug resistance element in vitro.


ensembl_gene_id: YHR179W
symbol: OYE2
gene_biotype: protein_coding
description:
  NADPH dehydrogenase 2; Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); responsible for geraniol reduction into citronellol during fermentation; homologous to Oye3p with different ligand binding and catalytic properties; may be involved in sterol metabolism, oxidative stress response, and programmed cell death; protein abundance increases in response to DNA replication stress; Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.


ensembl_gene_id: YHR180C-B
symbol: YHR180C-B
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YHR180C-B; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the dubious ORF YHR180W-A.


ensembl_gene_id: YHR180W
symbol: YHR180W
gene_biotype: protein_coding
description:
  Uncharacterized protein YHR180W; Putative protein of unknown function; conserved among S. cerevisiae strains.


ensembl_gene_id: YHR180W-A
symbol: YHR180W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YHR180W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps dubious ORF YHR180C-B and long terminal repeat YHRCsigma3.


ensembl_gene_id: YHR181W
symbol: SVP26
gene_biotype: protein_coding
description:
  Integral membrane protein of the early Golgi apparatus and ER; involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment.


ensembl_gene_id: YHR182C-A
symbol: YHR182C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YHR182C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF GND1/YHR183W.


ensembl_gene_id: YHR182W
symbol: YHR182W
gene_biotype: protein_coding
description:
  Uncharacterized protein YHR182W; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and cytoplasm; relocalizes from bud neck to cytoplasm upon DNA replication stress.


ensembl_gene_id: YHR183W
symbol: GND1
gene_biotype: protein_coding
description:
  6-phosphogluconate dehydrogenase (decarboxylating); catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone and adaptation to oxidative stress; GND1 has a paralog, GND2, that arose from the whole genome duplication.


ensembl_gene_id: YHR184W
symbol: SSP1
gene_biotype: protein_coding
description:
  Sporulation-specific protein 1; Protein involved in the control of meiotic nuclear division; involved in the coordination of meiosis with spore formation; subunit of the leading edge protein (LEP) complex (Ssp1-Ady3-Don1-Irc10) that forms a ring-like structure at the leading edge of the prospore membrane during meiosis II; required for assembly of the leading edge coat and both prospore membrane shaping and organization; transcription is induced midway through meiosis.


ensembl_gene_id: YHR185C
symbol: PFS1
gene_biotype: protein_coding
description:
  Sporulation protein required for prospore membrane formation; required for prospore membrane formation at selected spindle poles; ensures functionality of all four spindle pole bodies during meiosis II; not required for meiotic recombination or meiotic chromosome segregation.


ensembl_gene_id: YHR186C
symbol: KOG1
gene_biotype: protein_coding
description:
  Subunit of TORC1; TORC1 is a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors; Belongs to the WD repeat RAPTOR family.


ensembl_gene_id: YHR187W
symbol: IKI1
gene_biotype: protein_coding
description:
  Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin; Belongs to the ELP5 family.


ensembl_gene_id: YHR188C
symbol: GPI16
gene_biotype: protein_coding
description:
  GPI transamidase component GPI16; Subunit of the glycosylphosphatidylinositol transamidase complex; transmembrane protein; adds GPIs to newly synthesized proteins; human PIG-Tp homolog.


ensembl_gene_id: YHR189W
symbol: PTH1
gene_biotype: protein_coding
description:
  Peptidyl-tRNA hydrolase; One of two mitochondrially-localized peptidyl-tRNA hydrolases; dispensable for respiratory growth on rich medium, but required for respiratory growth on minimal medium; see also PTH2.


ensembl_gene_id: YHR190W
symbol: ERG9
gene_biotype: protein_coding
description:
  Squalene synthase; Farnesyl-diphosphate farnesyl transferase (squalene synthase); joins two farnesyl pyrophosphate moieties to form squalene in the sterol biosynthesis pathway.


ensembl_gene_id: YHR191C
symbol: CTF8
gene_biotype: protein_coding
description:
  Chromosome transmission fidelity protein 8; Subunit of a complex with Ctf18p; shares some subunits with Replication Factor C; required for sister chromatid cohesion; Belongs to the CTF8 family.


ensembl_gene_id: YHR192W
symbol: LNP1
gene_biotype: protein_coding
description:
  Endoplasmic reticulum junction formation protein lunapark; Lunapark family member involved in ER network formation; regulates the ER asymmetry-induced inheritance block during ER stress; localizes to ER junctions and this localization is regulated by the yeast atlastin ortholog Sey1p; interacts with the reticulon protein Rtn1p; induced in response to the DNA-damaging agent MMS.


ensembl_gene_id: YHR193C
symbol: EGD2
gene_biotype: protein_coding
description:
  Alpha subunit of the nascent polypeptide-associated complex (NAC); involved in protein sorting and translocation; associated with cytoplasmic ribosomes.


ensembl_gene_id: YHR193C-A
symbol: YHR193C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YHR193C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps verified ORF MDM31/YHR194W.


ensembl_gene_id: YHR194W
symbol: MDM31
gene_biotype: protein_coding
description:
  Mitochondrial distribution and morphology protein 31; Mitochondrial protein that may have a role in phospholipid metabolism; inner membrane protein with similarity to Mdm32p; required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MMM2, MDM10, MDM12, and MDM34; Belongs to the MDM31/MDM32 family.


ensembl_gene_id: YHR195W
symbol: NVJ1
gene_biotype: protein_coding
description:
  Nucleus-vacuole junction protein 1; Nuclear envelope protein; anchored to the nuclear inner membrane, that interacts with the vacuolar membrane protein Vac8p to promote formation of nucleus-vacuole junctions during piecemeal microautophagy of the nucleus (PMN).


ensembl_gene_id: YHR197W
symbol: RIX1
gene_biotype: protein_coding
description:
  Pre-rRNA-processing protein RIX1; Component of the Rix1 complex and possibly pre-replicative complexes; required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-replicative complex (pre-RC) formation and maintenance during DNA replication licensing; relocalizes to the cytosol in response to hypoxia; essential gene; Belongs to the RIX1/PELP1 family.


ensembl_gene_id: YHR198C
symbol: AIM18
gene_biotype: protein_coding
description:
  Altered inheritance of mitochondria protein 18, mitochondrial; Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss.


ensembl_gene_id: YHR199C
symbol: AIM46
gene_biotype: protein_coding
description:
  Altered inheritance of mitochondria protein 46, mitochondrial; Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss.


ensembl_gene_id: YHR199C-A
symbol: NBL1
gene_biotype: protein_coding
description:
  N-terminal-borealin-like protein; Subunit of the conserved chromosomal passenger complex (CPC); complex regulates mitotic chromosome segregation; not required for the kinase activity of the complex; mediates the interaction of Sli15p and Bir1p; other complex members are Ipl1p, Sli15p, and Bir1p; Belongs to the borealin family.


ensembl_gene_id: YHR200W
symbol: RPN10
gene_biotype: protein_coding
description:
  Non-ATPase base subunit of the 19S RP of the 26S proteasome; N-terminus plays a role in maintaining the structural integrity of the regulatory particle (RP); binds selectively to polyubiquitin chains; homolog of the mammalian S5a protein.


ensembl_gene_id: YHR201C
symbol: PPX1
gene_biotype: protein_coding
description:
  Exopolyphosphatase; hydrolyzes inorganic polyphosphate (poly P) into Pi residues; located in the cytosol, plasma membrane, and mitochondrial matrix; Belongs to the PPase class C family.


ensembl_gene_id: YHR202W
symbol: YHR202W
gene_biotype: protein_coding
description:
  Uncharacterized protein YHR202W; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole, while HA-tagged protein is found in the soluble fraction, suggesting cytoplasmic localization.


ensembl_gene_id: YHR203C
symbol: RPS4B
gene_biotype: protein_coding
description:
  Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4B has a paralog, RPS4A, that arose from the whole genome duplication.


ensembl_gene_id: YHR204W
symbol: MNL1
gene_biotype: protein_coding
description:
  ER degradation-enhancing alpha-mannosidase-like protein 1; Alpha-1,2-specific exomannosidase of the endoplasmic reticulum; involved in glycan trimming of both folded and misfolded glycoproteins; complexes with Pdi1p, and trims a mannose from Man8GlcNac2 glycans to generate Man7GlcNac2, an oligosaccharide signal on glycoproteins destined for ER-associated protein degradation; requires Pdi1p for stability and substrate recognition; human homolog EDEM1 can complement yeast null mutant; Belongs to the glycosyl hydrolase 47 family.


ensembl_gene_id: YHR205W
symbol: SCH9
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase SCH9; AGC family protein kinase; functional ortholog of mammalian S6 kinase; phosphorylated by Tor1p and required for TORC1-mediated regulation of ribosome biogenesis, translation initiation, and entry into G0 phase; involved in transactivation of osmostress-responsive genes; regulates G1 progression, cAPK activity and nitrogen activation of the FGM pathway; integrates nutrient signals and stress signals from sphingolipids to regulate lifespan.


ensembl_gene_id: YHR206W
symbol: SKN7
gene_biotype: protein_coding
description:
  Transcription factor SKN7; Nuclear response regulator and transcription factor; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; part of a branched two-component signaling system; required for optimal induction of heat-shock genes in response to oxidative stress; involved in osmoregulation; relocalizes to the cytosol in response to hypoxia; SKN7 has a paralog, HMS2, that arose from the whole genome duplication.


ensembl_gene_id: YHR207C
symbol: SET5
gene_biotype: protein_coding
description:
  Putative protein lysine methyltransferase SET5; Methyltransferase involved in methylation of histone H4 Lys5, -8, -12; S-adenosylmethionine-dependent; zinc-finger protein, contains one canonical and two unusual fingers in unusual arrangements; deletion enhances replication of positive-strand RNA virus; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET5 subfamily.


ensembl_gene_id: YHR208W
symbol: BAT1
gene_biotype: protein_coding
description:
  Branched-chain-amino-acid aminotransferase, mitochondrial; Mitochondrial branched-chain amino acid (BCAA) aminotransferase; preferentially involved in BCAA biosynthesis; homolog of murine ECA39; highly expressed during logarithmic phase and repressed during stationary phase; BAT1 has a paralog, BAT2, that arose from the whole genome duplication; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.


ensembl_gene_id: YHR209W
symbol: CRG1
gene_biotype: protein_coding
description:
  Probable S-adenosylmethionine-dependent methyltransferase CRG1; S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin; Belongs to the methyltransferase superfamily.


ensembl_gene_id: YHR210C
symbol: YHR210C
gene_biotype: protein_coding
description:
  Uncharacterized isomerase YHR210C; Putative aldose 1-epimerase superfamily protein; non-essential gene; highly expressed under anaeorbic conditions; Belongs to the aldose epimerase family.


ensembl_gene_id: YHR211W
symbol: FLO5
gene_biotype: protein_coding
description:
  Flocculation protein FLO5; Lectin-like cell wall protein (flocculin) involved in flocculation; binds mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; important for co-flocculation with other yeasts, mediating interaction with specific species; FLO5 has a paralog, FLO1, that arose from a segmental duplication; Belongs to the flocculin family.


ensembl_gene_id: YHR212C
symbol: YHR212C
gene_biotype: protein_coding
description:
  Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; YHR212C has a paralog, YAR060C, that arose from a segmental duplication.


ensembl_gene_id: YHR212W-A
symbol: YHR212W-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YAR061W; Pseudogenic fragment with similarity to flocculins; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; SWAT-GFP, seamless-GFP and mCherry fusion proteins localize to the endoplasmic reticulum; YHR212W-A has a paralog, YAR061W, that arose from a segmental duplication.


ensembl_gene_id: YHR213W
symbol: YHR213W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YAR062W; Pseudogenic fragment with similarity to flocculins; YHR213W has a paralog, YAR062W, that arose from a segmental duplication; Belongs to the flocculin family.


ensembl_gene_id: YHR213W-A
symbol: YHR213W-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YHR213W-A; Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching.


ensembl_gene_id: YHR213W-B
symbol: YHR213W-B
gene_biotype: protein_coding
description:
  Uncharacterized protein YHR213W-B; Pseudogenic fragment with similarity to flocculins; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; YHR213W-B has a paralog, YAR064W, that arose from a segmental duplication.


ensembl_gene_id: YHR214C-D
symbol: YHR214C-D
gene_biotype: protein_coding
description:
  Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; SWAT-GFP and mCherry fusion proteins localize to the nucleus and endoplasmic reticulum respectively; YHR214C-D has a paralog, YAR069C, that arose from a segmental duplication.


ensembl_gene_id: YHR214W
symbol: YHR214W
gene_biotype: protein_coding
description:
  Putative protein of unknown function; predicted to be a glycosylphosphatidylinositol-modified (GPI) protein; YHR214W has a paralog, YAR066W, that arose from a segmental duplication.


ensembl_gene_id: YHR214W-A
symbol: YHR214W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YHR214W-A; Dubious open reading frame; induced by zinc deficiency; YHR214W-A has a paralog, YAR068W, that arose from a segmental duplication.


ensembl_gene_id: YHR215W
symbol: PHO12
gene_biotype: protein_coding
description:
  One of three repressible acid phosphatases; glycoprotein that is transported to the cell surface by the secretory pathway; pregulated by phosphate starvation; PHO12 has a paralog, PHO11, that arose from a segmental duplication.


ensembl_gene_id: YHR216W
symbol: IMD2
gene_biotype: protein_coding
description:
  Inosine-5'-monophosphate dehydrogenase 2; Inosine monophosphate dehydrogenase; catalyzes the rate-limiting step in GTP biosynthesis, expression is induced by mycophenolic acid resulting in resistance to the drug, expression is repressed by nutrient limitation; IMD2 has a paralog, YAR073W/YAR075W, that arose from a segmental duplication.


ensembl_gene_id: YHR217C
symbol: YHR217C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YHR217C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; located in the telomeric region TEL08R.


ensembl_gene_id: YHR218W-A
symbol: YHR218W-A
gene_biotype: protein_coding
description:
  Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely within telomere TEL08L.


ensembl_gene_id: YHR219C-A
symbol: YHR219C-A
gene_biotype: protein_coding
description:
  Putative UPF0479 protein YHR219C-A; Dubious open reading frame unlikely to encode a functional protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; Belongs to the UPF0479 family.


ensembl_gene_id: YHR219W
symbol: YHR219W
gene_biotype: protein_coding
description:
  Putative protein of unknown function with similarity to helicases; located in the telomere region on the right arm of chromosome VIII.


ensembl_gene_id: YIL001W
symbol: YIL001W
gene_biotype: protein_coding
description:
  Ankyrin repeat-containing protein YIL001W; Putative protein of unknown function; contains a BTB/POZ domain which generally function in protein interactions; deletion slightly improved competitive fitness in rich media; GFP-tagged protein is localized to the cytoplasm.


ensembl_gene_id: YIL002C
symbol: INP51
gene_biotype: protein_coding
description:
  Phosphatidylinositol 4,5-bisphosphate 5-phosphatase; synaptojanin-like protein with an N-terminal Sac1 domain, plays a role in phosphatidylinositol 4,5-bisphosphate homeostasis and in endocytosis; null mutation confers cold-tolerant growth; In the central section; belongs to the inositol 1,4,5- trisphosphate 5-phosphatase family.


ensembl_gene_id: YIL002W-A
symbol: YIL002W-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YIL002W-A; Putative protein of unknown function; identified by expression profiling and mass spectrometry.


ensembl_gene_id: YIL003W
symbol: CFD1
gene_biotype: protein_coding
description:
  Cytosolic Fe-S cluster assembly factor CFD1; Highly conserved iron-sulfur cluster binding protein; localized in the cytoplasm; forms a complex with Nbp35p that is involved in iron-sulfur protein assembly in the cytosol.


ensembl_gene_id: YIL004C
symbol: BET1
gene_biotype: protein_coding
description:
  Type II membrane protein required for vesicular transport; required for vesicular transport between the endoplasmic reticulum and Golgi complex; v-SNARE with similarity to synaptobrevins; Belongs to the BET1 family.


ensembl_gene_id: YIL005W
symbol: EPS1
gene_biotype: protein_coding
description:
  ER-retained PMA1-suppressing protein 1; ER protein with chaperone and co-chaperone activity; involved in retention of resident ER proteins; has a role in recognizing proteins targeted for ER-associated degradation (ERAD), member of the protein disulfide isomerase family.


ensembl_gene_id: YIL006W
symbol: YIA6
gene_biotype: protein_coding
description:
  Mitochondrial nicotinamide adenine dinucleotide transporter 1; Mitochondrial NAD+ transporter; involved in the transport of NAD+ into the mitochondria (see also YEA6); member of the mitochondrial carrier subfamily; disputed role as a pyruvate transporter; has putative mouse and human orthologs; YIA6 has a paralog, YEA6, that arose from the whole genome duplication.


ensembl_gene_id: YIL007C
symbol: NAS2
gene_biotype: protein_coding
description:
  Probable 26S proteasome regulatory subunit p27; Evolutionarily conserved 19S regulatory particle assembly-chaperone; involved in assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); non-essential gene; interacts with Rpn4p; protein abundance increases in response to DNA replication stress; ortholog of human p27; Belongs to the proteasome subunit p27 family.


ensembl_gene_id: YIL008W
symbol: URM1
gene_biotype: protein_coding
description:
  Ubiquitin-related modifier 1; Ubiquitin-like protein involved in thiolation of cytoplasmic tRNAs; receives sulfur from the E1-like enzyme Uba4p and transfers it to tRNA; also functions as a protein tag with roles in nutrient sensing and oxidative stress response.


ensembl_gene_id: YIL009C-A
symbol: EST3
gene_biotype: protein_coding
description:
  Telomere replication protein EST3; Component of the telomerase holoenzyme; involved in telomere replication; synthesis of the full-length protein results from a programmed +1 ribosomal frameshift.


ensembl_gene_id: YIL009W
symbol: FAA3
gene_biotype: protein_coding
description:
  Long-chain-fatty-acid--CoA ligase 3; Long chain fatty acyl-CoA synthetase; activates imported fatty acids with a preference for C16:0-C18:0 chain lengths; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; Belongs to the ATP-dependent AMP-binding enzyme family.


ensembl_gene_id: YIL010W
symbol: DOT5
gene_biotype: protein_coding
description:
  Peroxiredoxin DOT5; Nuclear thiol peroxidase; functions as an alkyl-hydroperoxide reductase during post-diauxic growth; Belongs to the peroxiredoxin family. BCP/PrxQ subfamily.


ensembl_gene_id: YIL011W
symbol: TIR3
gene_biotype: protein_coding
description:
  Cell wall mannoprotein; member of Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth; TIR3 has a paralog, TIR2, that arose from the whole genome duplication.


ensembl_gene_id: YIL012W
symbol: YIL012W
gene_biotype: protein_coding
description:
  Uncharacterized protein YIL012W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YIL013C
symbol: PDR11
gene_biotype: protein_coding
description:
  ATP-dependent permease PDR11; ATP-binding cassette (ABC) transporter; multidrug transporter involved in multiple drug resistance; mediates sterol uptake when sterol biosynthesis is compromised; regulated by Pdr1p; required for anaerobic growth; PDR11 has a paralog, AUS1, that arose from the whole genome duplication; Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.


ensembl_gene_id: YIL014W
symbol: MNT3
gene_biotype: protein_coding
description:
  Alpha-1,3-mannosyltransferase; adds the fourth and fifth alpha-1,3-linked mannose residues to O-linked glycans during protein O-glycosylation; Belongs to the MNN1/MNT family.


ensembl_gene_id: YIL015W
symbol: BAR1
gene_biotype: protein_coding
description:
  Barrierpepsin; Aspartyl protease; secreted into the periplasmic space of mating type a cell; helps cells find mating partners; cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest; Belongs to the peptidase A1 family.


ensembl_gene_id: YIL016W
symbol: SNL1
gene_biotype: protein_coding
description:
  HSP70 co-chaperone SNL1; Ribosome-associated protein; proposed to act in protein synthesis and nuclear pore complex biogenesis and maintenance as well as protein folding; has similarity to the mammalian BAG-1 protein.


ensembl_gene_id: YIL017C
symbol: VID28
gene_biotype: protein_coding
description:
  Vacuolar import and degradation protein 28; GID Complex subunit, serves as adaptor for regulatory subunit Vid24p; protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); localized to the nucleus and the cytoplasm.


ensembl_gene_id: YIL018W
symbol: RPL2B
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L2B; homologous to mammalian ribosomal protein L2 and bacterial L2; RPL2B has a paralog, RPL2A, that arose from the whole genome duplication; expression is upregulated at low temperatures.


ensembl_gene_id: YIL020C
symbol: HIS6
gene_biotype: protein_coding
description:
  1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Enzyme that catalyzes the fourth step in the histidine pathway; Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts.


ensembl_gene_id: YIL020C-A
symbol: YIL020C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YIL020C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps origin of replication ARS918, partially overlaps ORF RPB3/YIL021W.


ensembl_gene_id: YIL021C-A
symbol: YIL021C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YIL021C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps verified gene RPB3/YIL021W; identified by gene-trapping, expression analysis, and genome-wide homology searching.


ensembl_gene_id: YIL021W
symbol: RPB3
gene_biotype: protein_coding
description:
  RNA polymerase II third largest subunit B44; part of central core; similar to prokaryotic alpha subunit.


ensembl_gene_id: YIL022W
symbol: TIM44
gene_biotype: protein_coding
description:
  Mitochondrial import inner membrane translocase subunit TIM44; Essential component of the TIM23 complex; tethers the import motor and regulatory factors (PAM complex) to the translocation channel (Tim23p-Tim17p core complex); TIM23 complex is short for the translocase of the inner mitochondrial membrane; Belongs to the Tim44 family.


ensembl_gene_id: YIL023C
symbol: YKE4
gene_biotype: protein_coding
description:
  Zinc transporter; localizes to the ER; null mutant is sensitive to calcofluor white, leads to zinc accumulation in cytosol; ortholog of the mouse KE4 and member of the ZIP (ZRT, IRT-like Protein) family; Belongs to the ZIP transporter (TC 2.A.5) family. KE4/Catsup subfamily.


ensembl_gene_id: YIL024C
symbol: YIL024C
gene_biotype: protein_coding
description:
  Uncharacterized protein YIL024C; Putative protein of unknown function; non-essential gene; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p.


ensembl_gene_id: YIL025C
symbol: YIL025C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YIL025C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YIL026C
symbol: IRR1
gene_biotype: protein_coding
description:
  Subunit of the cohesin complex; which is required for sister chromatid cohesion during mitosis and meiosis and interacts with centromeres and chromosome arms; relocalizes to the cytosol in response to hypoxia; essential for viability; Belongs to the SCC3 family.


ensembl_gene_id: YIL027C
symbol: EMC5
gene_biotype: protein_coding
description:
  Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response, and also shows K1 killer toxin resistance; homologous to worm B0334.15/EMC-5, fly CG15168, human MMGT.


ensembl_gene_id: YIL028W
symbol: YIL028W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YIL028W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YIL029C
symbol: YIL029C
gene_biotype: protein_coding
description:
  Uncharacterized protein YIL029C; Putative protein of unknown function; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YIL029C has a paralog, YPR071W, that arose from a single-locus duplication.


ensembl_gene_id: YIL029W-A
symbol: YIL029W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YIL029W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF SSM4/YIL030C.


ensembl_gene_id: YIL030C
symbol: SSM4
gene_biotype: protein_coding
description:
  ERAD-associated E3 ubiquitin-protein ligase DOA10; Membrane-embedded ubiquitin-protein ligase; ER and inner nuclear membrane localized RING-CH domain E3 ligase involved in ER-associated protein degradation (ERAD); targets misfolded cytosolic/nucleoplasmic domains of soluble and membrane embedded proteins (ERAD-C) and a transmembrane domain containing substrate (ERAD-M), Sbh2p; C-terminal element (CTE), conserved in human ortholog MARCH10/TEB4, determines substrate selectivity.


ensembl_gene_id: YIL030W-A
symbol: YIL030W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized membrane protein YIL030W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps ORF ULP2/YIL031W.


ensembl_gene_id: YIL031W
symbol: ULP2
gene_biotype: protein_coding
description:
  Ubiquitin-like-specific protease 2; Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins; plays a role in chromosome cohesion at centromeric regions and recovery from checkpoint arrest induced by DNA damage or DNA replication defects; potential Cdc28p substrate; human homolog PML implicated in promyelocytic leukemia can partially complement yeast null mutant; Belongs to the peptidase C48 family.


ensembl_gene_id: YIL032C
symbol: YIL032C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YIL032C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YIL033C
symbol: BCY1
gene_biotype: protein_coding
description:
  Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA); PKA is a component of a signaling pathway that controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation.


ensembl_gene_id: YIL034C
symbol: CAP2
gene_biotype: protein_coding
description:
  Beta subunit of the capping protein heterodimer (Cap1p and Cap2p); capping protein (CP) binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches; protein increases in abundance and relocalizes from bud neck to plasma membrane upon DNA replication stress.


ensembl_gene_id: YIL035C
symbol: CKA1
gene_biotype: protein_coding
description:
  Alpha catalytic subunit of casein kinase 2 (CK2); a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; regulates Fkh1p-mediated donor preference during mating-type switching.


ensembl_gene_id: YIL036W
symbol: CST6
gene_biotype: protein_coding
description:
  ATF/CREB activator 2; Basic leucine zipper (bZIP) transcription factor from ATF/CREB family involved in stress-responsive regulatory network; mediates transcriptional activation of NCE103 in response to low CO2 levels; proposed to be a regulator of oleate responsive genes; involved in utilization of non-optimal carbon sources and chromosome stability; relocalizes to the cytosol in response to hypoxia; CST6 has a paralog, ACA1, that arose from the whole genome duplication.


ensembl_gene_id: YIL037C
symbol: PRM2
gene_biotype: protein_coding
description:
  Pheromone-regulated protein; predicted to have 4 transmembrane segments and a coiled coil domain; regulated by Ste12p; required for efficient nuclear fusion.


ensembl_gene_id: YIL038C
symbol: NOT3
gene_biotype: protein_coding
description:
  General negative regulator of transcription subunit 3; Component of the CCR4-NOT core complex, involved in mRNA decapping; involved in transcription initiation and elongation and in mRNA degradation; conserved lysine in human homolog of Not3p and Not5p is mutated in cancers.


ensembl_gene_id: YIL039W
symbol: TED1
gene_biotype: protein_coding
description:
  Protein TED1; GPI-glycan remodelase; conserved phosphoesterase domain-containing protein; acts together with Emp24p/Erv25p in cargo exit from the ER; functional ortholog of mammalian GPI-glycan remodelase PGAP5; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO).


ensembl_gene_id: YIL040W
symbol: APQ12
gene_biotype: protein_coding
description:
  Nuclear envelope/ER integral membrane protein; interacts and functions with Brr6p and Brl1p in lipid homeostasis; mutants are defective in nuclear pore complex biogenesis, nuclear envelope morphology, mRNA export from the nucleus and are sensitive to sterol biosynthesis inhibitors and membrane fluidizing agents; exhibits synthetic lethal genetic interactions with genes involved in lipid metabolism; Belongs to the APQ12 family.


ensembl_gene_id: YIL041W
symbol: GVP36
gene_biotype: protein_coding
description:
  BAR domain protein that localizes to early and late Golgi vesicles; required for adaptation to varying nutrient concentrations, fluid-phase endocytosis, polarization of the actin cytoskeleton, and vacuole biogenesis.


ensembl_gene_id: YIL042C
symbol: PKP1
gene_biotype: protein_coding
description:
  Mitochondrial protein kinase; involved in negative regulation of pyruvate dehydrogenase complex activity by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp2p and phosphatases Ptc5p and Ptc6p.


ensembl_gene_id: YIL043C
symbol: CBR1
gene_biotype: protein_coding
description:
  NADH-cytochrome b5 reductase 1; Cytochrome b reductase; not essential for viability; also detected in mitochondria; mutation in conserved NADH binding domain of the human ortholog results in type I methemoglobinemia.


ensembl_gene_id: YIL044C
symbol: AGE2
gene_biotype: protein_coding
description:
  ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector; involved in Trans-Golgi-Network (TGN) transport; contains C2C2H2 cysteine/histidine motif.


ensembl_gene_id: YIL045W
symbol: PIG2
gene_biotype: protein_coding
description:
  GSY2-interacting protein PIG2; Putative type-1 protein phosphatase targeting subunit; tethers Glc7p type-1 protein phosphatase to Gsy2p glycogen synthase; PIG2 has a paralog, GIP2, that arose from the whole genome duplication.


ensembl_gene_id: YIL046W
symbol: MET30
gene_biotype: protein_coding
description:
  F-box protein containing five copies of the WD40 motif; controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and regulates Met4p, localizes within the nucleus; dissociation of Met30p from SCF complex in response to cadmium stress is regulated by Cdc48p.


ensembl_gene_id: YIL046W-A
symbol: YIL046W-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YIL046W-A; Putative protein of unknown function; identified by expression profiling and mass spectrometry.


ensembl_gene_id: YIL047C
symbol: SYG1
gene_biotype: protein_coding
description:
  Plasma membrane protein of unknown function; truncation and overexpression suppresses lethality of G-alpha protein deficiency.


ensembl_gene_id: YIL047C-A
symbol: YIL047C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YIL047C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF SYG1/YIL047C.


ensembl_gene_id: YIL048W
symbol: NEO1
gene_biotype: protein_coding
description:
  Probable phospholipid-transporting ATPase NEO1; Phospholipid translocase (flippase), role in phospholipid asymmetry of plasma membrane; involved in endocytosis, vacuolar biogenesis and Golgi to ER vesicle-mediated transport; localizes to endosomes and the Golgi apparatus.


ensembl_gene_id: YIL049W
symbol: DFG10
gene_biotype: protein_coding
description:
  Probable polyprenol reductase; catalyzes conversion of polyprenol to dolichol, the precursor for N-glycosylation; involved in filamentous growth; mutations in human homolog SRD5A3 confer CDG (Congenital Disorders of Glycosylation); human SRD5A3 can complement yeast null mutant.


ensembl_gene_id: YIL050W
symbol: PCL7
gene_biotype: protein_coding
description:
  Pho85p cyclin of the Pho80p subfamily; forms a functional kinase complex with Pho85p which phosphorylates Mmr1p and is regulated by Pho81p; involved in glycogen metabolism, expression is cell-cycle regulated; PCL7 has a paralog, PCL6, that arose from the whole genome duplication.


ensembl_gene_id: YIL051C
symbol: MMF1
gene_biotype: protein_coding
description:
  Mitochondrial protein required for transamination of isoleucine; but not of valine or leucine; may regulate specificity of branched-chain transaminases Bat1p and Bat2p; induction of expression in response to stress is mediated by a Hog1p-regulated antisense RNA and gene looping; interacts genetically with mitochondrial ribosomal protein genes; MMF1 has a paralog, HMF1, that arose from the whole genome duplication.


ensembl_gene_id: YIL052C
symbol: RPL34B
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication.


ensembl_gene_id: YIL053W
symbol: GPP1
gene_biotype: protein_coding
description:
  Glycerol-1-phosphate phosphohydrolase 1; Constitutively expressed DL-glycerol-3-phosphate phosphatase; also known as glycerol-1-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and osmotic stress; GPP1 has a paralog, GPP2, that arose from the whole genome duplication.


ensembl_gene_id: YIL054W
symbol: YIL054W
gene_biotype: protein_coding
description:
  Uncharacterized membrane protein YIL054W; Protein of unknown function; expressed at both mRNA and protein levels.


ensembl_gene_id: YIL056W
symbol: VHR1
gene_biotype: protein_coding
description:
  Transcription factor VHR1; Transcriptional activator; required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations; VHR1 has a paralog, VHR2, that arose from the whole genome duplication.


ensembl_gene_id: YIL057C
symbol: RGI2
gene_biotype: protein_coding
description:
  Respiratory growth induced protein 2; Protein of unknown function; involved in energy metabolism under respiratory conditions; expression induced under carbon limitation and repressed under high glucose; RGI2 has a paralog, RGI1, that arose from the whole genome duplication.


ensembl_gene_id: YIL058W
symbol: YIL058W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YIL058W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YIL059C
symbol: YIL059C
gene_biotype: protein_coding
description:
  Uncharacterized protein YIL059C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YIL060W.


ensembl_gene_id: YIL060W
symbol: YIL060W
gene_biotype: protein_coding
description:
  Uncharacterized protein YIL060W; Mitochondrial protein of unknown function; required for respiratory growth; mutant accumulates less glycogen than does wild type; null mutation results in a decrease in plasma membrane electron transport; YIL060W is not an essential gene.


ensembl_gene_id: YIL061C
symbol: SNP1
gene_biotype: protein_coding
description:
  U1 small nuclear ribonucleoprotein 70 kDa homolog; Component of U1 snRNP required for mRNA splicing via spliceosome; substrate of the arginine methyltransferase Hmt1p; may interact with poly(A) polymerase to regulate polyadenylation; homolog of human U1 70K protein; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YIL062C
symbol: ARC15
gene_biotype: protein_coding
description:
  Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches; has mRNA binding activity; Belongs to the ARPC5 family.


ensembl_gene_id: YIL063C
symbol: YRB2
gene_biotype: protein_coding
description:
  Ran-specific GTPase-activating protein 2; Protein of unknown function; involved in nuclear processes of the Ran-GTPase cycle; involved in nuclear protein export; contains Ran Binding Domain and FxFG repeats; interacts with Srm1p, GTP-Gsp1p, Rna1p and Crm1p; relocalizes to the cytosol in response to hypoxia; not essential for viability.


ensembl_gene_id: YIL064W
symbol: EFM4
gene_biotype: protein_coding
description:
  Protein-lysine N-methyltransferase EFM4; Lysine methyltransferase; involved in the dimethylation of eEF1A (Tef1p/Tef2p) at lysine 316; sequence similarity to S-adenosylmethionine-dependent methyltransferases of the seven beta-strand family; role in vesicular transport; Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.


ensembl_gene_id: YIL065C
symbol: FIS1
gene_biotype: protein_coding
description:
  Protein involved in mitochondrial fission and peroxisome abundance; may have a distinct role in tethering protein aggregates to mitochondria in order to retain them in the mother cell; required for localization of Dnm1p and Mdv1p during mitochondrial division; mediates ethanol-induced apoptosis and ethanol-induced mitochondrial fragmentation; Belongs to the FIS1 family.


ensembl_gene_id: YIL066C
symbol: RNR3
gene_biotype: protein_coding
description:
  Ribonucleoside-diphosphate reductase large chain 2; Minor isoform of large subunit of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits; RNR3 has a paralog, RNR1, that arose from the whole genome duplication.


ensembl_gene_id: YIL066W-A
symbol: YIL066W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized membrane protein YIL066W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF YIL067C.


ensembl_gene_id: YIL068C
symbol: SEC6
gene_biotype: protein_coding
description:
  Essential 88kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; anchors the assembled complex to sites of secretion; interacts with SM-like protein and SNARE regulator Sec1p and may recruit it to sites of secretion; binds to SNARE complexes binteracting with Sec9p.


ensembl_gene_id: YIL068W-A
symbol: YIL068W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YIL068W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF SEC6/YIL068C.


ensembl_gene_id: YIL069C
symbol: RPS24B
gene_biotype: protein_coding
description:
  Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S24, no bacterial homolog; RPS24B has a paralog, RPS24A, that arose from the whole genome duplication.


ensembl_gene_id: YIL070C
symbol: MAM33
gene_biotype: protein_coding
description:
  Mitochondrial acidic protein MAM33; Specific translational activator for the mitochondrial COX1 mRNA; acidic protein of the mitochondrial matrix; related to the human complement receptor gC1q-R; Belongs to the MAM33 family.


ensembl_gene_id: YIL071C
symbol: PCI8
gene_biotype: protein_coding
description:
  Possible shared subunit of Cop9 signalosome (CSN) and eIF3; binds eIF3b subunit Prt1p, has possible dual functions in transcriptional and translational control, contains a PCI (Proteasome-COP9 signalosome (CSN)-eIF3) domain.


ensembl_gene_id: YIL071W-A
symbol: YIL071W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YIL071W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF PCI8/YIL071C.


ensembl_gene_id: YIL072W
symbol: HOP1
gene_biotype: protein_coding
description:
  Meiosis-specific protein required for chromosome synapsis; displays Red1p dependent localization to the unsynapsed axial-lateral elements of the synaptonemal complex; required for chiasma formation; in vitro, displays the ability to promote intra- and intermolecular synapsis between double-stranded DNA molecules and to fold DNA into rigid protein-DNA filaments.


ensembl_gene_id: YIL073C
symbol: SPO22
gene_biotype: protein_coding
description:
  Sporulation-specific protein 22; Meiosis-specific protein essential for chromosome synapsis; involved in completion of nuclear divisions during meiosis; induced early in meiosis.


ensembl_gene_id: YIL074C
symbol: SER33
gene_biotype: protein_coding
description:
  D-3-phosphoglycerate dehydrogenase 2; 3-phosphoglycerate dehydrogenase and alpha-ketoglutarate reductase; 3PG dehydrogenase that catalyzes the first step in serine and glycine biosynthesis; also functions as an alpha-ketoglutarate reductase, converting alpha-ketoglutarate to D-2-hydroxyglutarate (D-2HG); localizes to the cytoplasm; SER33 has a paralog, SER3, that arose from the whole genome duplication.


ensembl_gene_id: YIL075C
symbol: RPN2
gene_biotype: protein_coding
description:
  Subunit of the 26S proteasome; substrate of the N-acetyltransferase Nat1p; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YIL076W
symbol: SEC28
gene_biotype: protein_coding
description:
  Epsilon-COP subunit of the coatomer; regulates retrograde Golgi-to-ER protein traffic; stabilizes Cop1p, the alpha-COP and the coatomer complex; non-essential for cell growth; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YIL077C
symbol: YIL077C
gene_biotype: protein_coding
description:
  PUP1 protein homolog; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); Belongs to the PUP1 family.


ensembl_gene_id: YIL078W
symbol: THS1
gene_biotype: protein_coding
description:
  Threonine--tRNA ligase, cytoplasmic; Threonyl-tRNA synthetase; essential cytoplasmic protein; human homolog TARS can complement yeast null mutant.


ensembl_gene_id: YIL079C
symbol: AIR1
gene_biotype: protein_coding
description:
  Zinc knuckle protein; involved in nuclear RNA processing and degradation as a component of the TRAMP complex; stimulates the poly(A) polymerase activity of Pap2p in vitro; AIR1 has a paralog, AIR2, that arose from the whole genome duplication; although Air1p and Air2p are homologous TRAMP subunits, they have nonredundant roles in regulation of substrate specificity of the exosome.


ensembl_gene_id: YIL082W
symbol: YIL082W
gene_biotype: protein_coding
description:
  Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag.


ensembl_gene_id: YIL083C
symbol: CAB2
gene_biotype: protein_coding
description:
  Phosphopantothenate--cysteine ligase CAB2; Subunit of the CoA-Synthesizing Protein Complex (CoA-SPC); subunits of this complex are: Cab2p, Cab3p, Cab4p, Cab5p, Sis2p and Vhs3p; probable phosphopantothenoylcysteine synthetase (PPCS), which catalyzes the second step of coenzyme A biosynthesis from pantothenate; null mutant lethality is complemented by human homolog PPCS and by E. coli coaBC (encoding a bifunctional enzyme with PPCS activity).


ensembl_gene_id: YIL084C
symbol: SDS3
gene_biotype: protein_coding
description:
  Transcriptional regulatory protein SDS3; Component of the Rpd3L histone deacetylase complex; required for its structural integrity and catalytic activity, involved in transcriptional silencing and required for sporulation; relocalizes to the cytosol in response to hypoxia; cells defective in SDS3 display pleiotropic phenotypes.


ensembl_gene_id: YIL085C
symbol: KTR7
gene_biotype: protein_coding
description:
  Probable mannosyltransferase KTR7; Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; KTR7 has a paralog, KTR5, that arose from the whole genome duplication.


ensembl_gene_id: YIL086C
symbol: YIL086C
gene_biotype: protein_coding
description:
  Uncharacterized protein YIL086C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YIL087C
symbol: AIM19
gene_biotype: protein_coding
description:
  Protein of unknown function; mitochondrial protein that physically interacts with Tim23p; null mutant displays reduced respiratory growth; Belongs to the AIM19 family.


ensembl_gene_id: YIL088C
symbol: AVT7
gene_biotype: protein_coding
description:
  Vacuolar amino acid transporter 7; Putative transporter; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters.


ensembl_gene_id: YIL089W
symbol: YIL089W
gene_biotype: protein_coding
description:
  Uncharacterized membrane protein YIL089W; Protein of unknown function found in the ER and vacuole lumen; overexpression of YIL089W affects endocytic protein trafficking.


ensembl_gene_id: YIL090W
symbol: ICE2
gene_biotype: protein_coding
description:
  Protein ICE2; Integral ER membrane protein with type-III transmembrane domains; required for maintenance of ER zinc homeostasis; necessary for efficient targeting of Trm1p tRNA methyltransferase to inner nuclear membrane; mutations cause defects in cortical ER morphology in both the mother and daughter cells.


ensembl_gene_id: YIL091C
symbol: UTP25
gene_biotype: protein_coding
description:
  U3 small nucleolar RNA-associated protein 25; Nucleolar protein; required for 35S pre-RNA processing and 40S ribosomal subunit biogenesis.


ensembl_gene_id: YIL092W
symbol: YIL092W
gene_biotype: protein_coding
description:
  Uncharacterized protein YIL092W; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus.


ensembl_gene_id: YIL094C
symbol: LYS12
gene_biotype: protein_coding
description:
  Homoisocitrate dehydrogenase, mitochondrial; Homo-isocitrate dehydrogenase; an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine, in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipate.


ensembl_gene_id: YIL095W
symbol: PRK1
gene_biotype: protein_coding
description:
  Actin-regulating kinase PRK1; Protein serine/threonine kinase; regulates the organization and function of the actin cytoskeleton and reduces endocytic ability of cell through the phosphorylation of the Pan1p-Sla1p-End3p protein complex; PRK1 has a paralog, ARK1, that arose from the whole genome duplication.


ensembl_gene_id: YIL096C
symbol: BMT5
gene_biotype: protein_coding
description:
  Methyltransferase required for m3U2634 methylation of the 25S rRNA; S-adenosylmethionine-dependent; associates with precursors of the 60S ribosomal subunit; predicted to be involved in ribosome biogenesis; Belongs to the class I-like SAM-binding methyltransferase superfamily. BMT5 family.


ensembl_gene_id: YIL097W
symbol: FYV10
gene_biotype: protein_coding
description:
  Protein FYV10; Subunit of GID complex; involved in proteasome-dependent catabolite inactivation of gluconeogenic enzymes FBPase, PEPCK, and c-MDH; forms dimer with Rmd5p that is then recruited to GID Complex by Gid8p; contains a degenerate RING finger motif needed for GID complex ubiquitin ligase activity in vivo, as well as CTLH and CRA domains; plays role in anti-apoptosis; required for survival upon exposure to K1 killer toxin; Belongs to the FYV10 family.


ensembl_gene_id: YIL098C
symbol: FMC1
gene_biotype: protein_coding
description:
  ATP synthase assembly factor FMC1, mitochondrial; Mitochondrial matrix protein; required for assembly or stability at high temperature of the F1 sector of mitochondrial F1F0 ATP synthase; null mutant temperature sensitive growth on glycerol is suppressed by multicopy expression of Odc1p.


ensembl_gene_id: YIL099W
symbol: SGA1
gene_biotype: protein_coding
description:
  Intracellular sporulation-specific glucoamylase; involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation.


ensembl_gene_id: YIL100C-A
symbol: YIL100C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YIL100C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YIL100W
symbol: YIL100W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YIL100W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the dubious ORF YIL100C-A.


ensembl_gene_id: YIL101C
symbol: XBP1
gene_biotype: protein_coding
description:
  Transcriptional repressor; binds promoter sequences of cyclin genes, CYS3, and SMF2; not expressed during log phase of growth, but induced by stress or starvation during mitosis, and late in meiosis; represses 15% of all yeast genes as cells transition to quiescence; important for maintaining G1 arrest and for longevity of quiescent cells; member of Swi4p/Mbp1p family; phosphorylated by Cdc28p; relative distribution to nucleus increases upon DNA replication stress.


ensembl_gene_id: YIL102C-A
symbol: YIL102C-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YIL102C-A; Putative protein of unknown function; identified based on comparisons of the genome sequences of six Saccharomyces species; SWAT-GFP, seamless-GFP and mCherry fusion proteins localize to the endoplasmic reticulum.


ensembl_gene_id: YIL103W
symbol: DPH1
gene_biotype: protein_coding
description:
  2-(3-amino-3-carboxypropyl)histidine synthase subunit 1; Protein required for synthesis of diphthamide; required along with Dph2p, Kti11p, Jjj3p, and Dph5p; diphthamide is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph2p and Kti11p.


ensembl_gene_id: YIL104C
symbol: SHQ1
gene_biotype: protein_coding
description:
  Chaperone protein; required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing; functions as an RNA mimic; forms a complex with Naf1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; homology with known Hsp90p cochaperones; relocalizes to the cytosol in response to hypoxia; Belongs to the SHQ1 family.


ensembl_gene_id: YIL105C
symbol: SLM1
gene_biotype: protein_coding
description:
  Phosphatidylinositol 4,5-bisphosphate-binding protein SLM1; Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; TORC2 complex substrate and effector; protein abundance increases in response to DNA replication stress; SLM1 has a paralog, SLM2, that arose from the whole genome duplication.


ensembl_gene_id: YIL105W-A
symbol: YIL105W-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YIL105W-A; Protein of unknown function; completely overlaps the verified gene SLM1; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; mRNA identified as translated by ribosome profiling data.


ensembl_gene_id: YIL106W
symbol: MOB1
gene_biotype: protein_coding
description:
  DBF2 kinase activator protein MOB1; Component of the mitotic exit network; associates with and is required for the activation and Cdc15p-dependent phosphorylation of the Dbf2p kinase; required for cytokinesis and cell separation; component of the CCR4 transcriptional complex; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress; Belongs to the MOB1/phocein family.


ensembl_gene_id: YIL107C
symbol: PFK26
gene_biotype: protein_coding
description:
  6-phosphofructo-2-kinase; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A.


ensembl_gene_id: YIL108W
symbol: YIL108W
gene_biotype: protein_coding
description:
  Putative zinc metalloproteinase YIL108W; Putative metalloendopeptidase; forms cytoplasmic foci upon DNA replication stress; Belongs to the peptidase M10B family.


ensembl_gene_id: YIL109C
symbol: SEC24
gene_biotype: protein_coding
description:
  Protein transport protein SEC24; Component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat; required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sfb3p; SEC24 has a paralog, SFB2, that arose from the whole genome duplication; Belongs to the SEC23/SEC24 family. SEC24 subfamily.


ensembl_gene_id: YIL110W
symbol: HPM1
gene_biotype: protein_coding
description:
  AdoMet-dependent methyltransferase; involved in a novel 3-methylhistidine modification of ribosomal protein Rpl3p; seven beta-strand MTase family member; null mutant exhibits a weak vacuolar protein sorting defect and caspofungin resistance; Belongs to the methyltransferase superfamily. METTL18 family.


ensembl_gene_id: YIL111W
symbol: COX5B
gene_biotype: protein_coding
description:
  Subunit Vb of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Bp is predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth; COX5B has a paralog, COX5A, that arose from the whole genome duplication.


ensembl_gene_id: YIL112W
symbol: HOS4
gene_biotype: protein_coding
description:
  Protein HOS4; Subunit of the Set3 complex; complex is a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; potential Cdc28p substrate.


ensembl_gene_id: YIL113W
symbol: SDP1
gene_biotype: protein_coding
description:
  Stress-inducible dual-specificity MAP kinase phosphatase; negatively regulates Slt2p MAP kinase by direct dephosphorylation, diffuse localization under normal conditions shifts to punctate localization after heat shock; SDP1 has a paralog, MSG5, that arose from the whole genome duplication; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.


ensembl_gene_id: YIL114C
symbol: POR2
gene_biotype: protein_coding
description:
  Mitochondrial outer membrane protein porin 2; Putative mitochondrial porin (voltage-dependent anion channel); not required for mitochondrial membrane permeability or mitochondrial osmotic stability; POR2 has a paralog, POR1, that arose from the whole genome duplication.


ensembl_gene_id: YIL115C
symbol: NUP159
gene_biotype: protein_coding
description:
  FG-nucleoporin component of central core of the nuclear pore complex; also part of the nuclear pore complex (NPC) cytoplasmic filaments; contributes directly to nucleocytoplasmic transport; regulates ADP release from the ATP-dependent RNA helicase Dbp5p; forms a stable association with Nup82p, Gle2p and two other FG-nucleoporins (Nsp1p and Nup116p).


ensembl_gene_id: YIL115W-A
symbol: YIL115W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YIL115W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene NUP159/YIL115C.


ensembl_gene_id: YIL116W
symbol: HIS5
gene_biotype: protein_coding
description:
  Histidinol-phosphate aminotransferase; catalyzes the seventh step in histidine biosynthesis; responsive to general control of amino acid biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts.


ensembl_gene_id: YIL117C
symbol: PRM5
gene_biotype: protein_coding
description:
  Pheromone-regulated protein, predicted to have 1 transmembrane segment; induced during cell integrity signaling; PRM5 has a paralog, YNL058C, that arose from the whole genome duplication.


ensembl_gene_id: YIL118W
symbol: RHO3
gene_biotype: protein_coding
description:
  GTP-binding protein RHO3; Non-essential small GTPase of the Rho/Rac family of Ras-like proteins; involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p.


ensembl_gene_id: YIL119C
symbol: RPI1
gene_biotype: protein_coding
description:
  Negative RAS protein regulator protein; Transcription factor, allelic differences between S288C and Sigma1278b; mediates fermentation stress tolerance by modulating cell wall integrity; overexpression suppresses heat shock sensitivity of wild-type RAS2 overexpression and also suppresses cell lysis defect of mpk1 mutation; allele from S288c can confer fMAPK pathway independent transcription of FLO11; S288C and Sigma1278b alleles differ in number of tandem repeats within ORF.


ensembl_gene_id: YIL120W
symbol: QDR1
gene_biotype: protein_coding
description:
  Quinidine resistance protein 1; Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; involved in spore wall assembly; sequence similarity to DTR1 and QDR3, and the triple mutant dtr1 qdr1 qdr3 exhibits reduced dityrosine fluorescence relative to the single mutants; required for resistance to quinidine, ketoconazole, fluconazole, and barban; QDR1 has a paralog, AQR1, that arose from the whole genome duplication.


ensembl_gene_id: YIL121W
symbol: QDR2
gene_biotype: protein_coding
description:
  Quinidine resistance protein 2; Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; exports copper; has broad substrate specificity and can transport many mono- and divalent cations; transports a variety of drugs and is required for resistance to quinidine, barban, cisplatin, and bleomycin; contributes to potassium homeostasis; expression is regulated by copper.


ensembl_gene_id: YIL122W
symbol: POG1
gene_biotype: protein_coding
description:
  Transcriptional activator POG1; Nuclear chromatin-associated protein of unknown function; may have a role in cell cycle regulation; overexpression promotes recovery from pheromone induced arrest and suppresses the stress sensitivity caused by a mutation in the E3 ubiquitin ligase Rsp5p; binds upstream of BAR1 and cell cycle-related genes; phsosphoylated form may be ubiquitinated by Dma2p; potential Cdc28p substrate; SBF regulated.


ensembl_gene_id: YIL123W
symbol: SIM1
gene_biotype: protein_coding
description:
  Probable secreted beta-glucosidase SIM1; Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p); may participate in DNA replication; promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated; SIM1 has a paralog, SUN4, that arose from the whole genome duplication.


ensembl_gene_id: YIL124W
symbol: AYR1
gene_biotype: protein_coding
description:
  Bifunctional triacylglycerol lipase and 1-acyl DHAP reductase; NADPH-dependent 1-acyl dihydroxyacetone phosphate reductase involved in phosphatidic acid biosynthesis; lipid droplet triacylglycerol lipase involved in the mobilization of non-polar lipids; found in lipid particles, the endoplasmic reticulum and the mitochondrial outer membrane; required for spore germination; role in cell wall biosynthesis; capable of metabolizing steroid hormones; oleic acid inducible; Belongs to the short-chain dehydrogenases/reductases (SDR) family.


ensembl_gene_id: YIL125W
symbol: KGD1
gene_biotype: protein_coding
description:
  2-oxoglutarate dehydrogenase, mitochondrial; Subunit of the mitochondrial alpha-ketoglutarate dehydrogenase complex; catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA.


ensembl_gene_id: YIL126W
symbol: STH1
gene_biotype: protein_coding
description:
  Nuclear protein STH1/NPS1; ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; promotes base excision repair in chromatin; essential helicase-related protein homologous to Snf2p.


ensembl_gene_id: YIL127C
symbol: RRT14
gene_biotype: protein_coding
description:
  Regulator of rDNA transcription protein 14; Putative protein of unknown function; identified in a screen for mutants with decreased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis.


ensembl_gene_id: YIL128W
symbol: MET18
gene_biotype: protein_coding
description:
  DNA repair/transcription protein MET18/MMS19; Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Cia2p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; ortholog of human MMS19; Belongs to the MET18/MMS19 family.


ensembl_gene_id: YIL129C
symbol: TAO3
gene_biotype: protein_coding
description:
  Cell morphogenesis protein PAG1; Component of the RAM signaling network; is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p; To S.pombe mor2.


ensembl_gene_id: YIL130W
symbol: ASG1
gene_biotype: protein_coding
description:
  Activator of stress genes 1; Zinc cluster protein proposed to be a transcriptional regulator; regulator involved in the stress response; null mutants have a respiratory deficiency, calcofluor white sensitivity and slightly increased cycloheximide resistance; Belongs to the ASG1 family.


ensembl_gene_id: YIL131C
symbol: FKH1
gene_biotype: protein_coding
description:
  Fork head protein homolog 1; Forkhead family transcription factor; rate-limiting replication origin activator; evolutionarily conserved lifespan regulator; binds multiple chromosomal elements with distinct specificities, cell cycle dynamics; regulates transcription elongation, chromatin silencing at mating loci, expression of G2/M phase genes; facilitates clustering, activation of early-firing replication origins; binds HML recombination enhancer, regulates donor preference during mating-type switching.


ensembl_gene_id: YIL132C
symbol: CSM2
gene_biotype: protein_coding
description:
  Chromosome segregation in meiosis protein 2; Component of Shu complex (aka PCSS complex); Shu complex also includes Psy3, Shu1, Shu2, and promotes error-free DNA repair,; Shu complex mediates inhibition of Srs2p function; promotes formation of Rad51p filaments; Psy3p and Csm2p contain similar DNA-binding regions which work together to form a single DNA binding site; required for accurate chromosome segregation during meiosis.


ensembl_gene_id: YIL133C
symbol: RPL16A
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L16A; N-terminally acetylated, binds 5.8 S rRNA; transcriptionally regulated by Rap1p; homologous to mammalian ribosomal protein L13A and bacterial L13; RPL16A has a paralog, RPL16B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YIL134C-A
symbol: YIL134C-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YIL134C-A; Putative protein of unknown function; identified by fungal homology and RT-PCR.


ensembl_gene_id: YIL134W
symbol: FLX1
gene_biotype: protein_coding
description:
  Mitochondrial FAD carrier protein FLX1; Mitochondrial flavin adenine dinucleotide transporter; FAD is a synthesis product of riboflavin; human homolog SLC25A32 is implicated in multiple acyl-CoA dehydrogenase deficiency (MADD) or glutaric aciduria type II (GAII), and can complement yeast null mutant; Belongs to the mitochondrial carrier (TC 2.A.29) family.


ensembl_gene_id: YIL135C
symbol: VHS2
gene_biotype: protein_coding
description:
  Protein VHS2; Regulator of septin dynamics; involved in the regulation of septin dynamics at bud neck after mitotic entry, likely by stabilizing septin structure; regulated at post-translational level by cell cycle dependent phosphorylation; likely phosphorylated by Cdc28p and dephosphorylated by Cdc14p before cytokinesis; high-copy suppressor of synthetic lethality of sis2 sit4 double mutant; VHS2 has a paralog, MLF3, that arose from the whole genome duplication.


ensembl_gene_id: YIL136W
symbol: OM45
gene_biotype: protein_coding
description:
  Mitochondrial outer membrane protein of unknown function; major constituent of the outer membrane, extending into the intermembrane space; interacts with porin (Por1p) and with Om14p; imported via the presequence pathway involving the TOM and TIM23 complexes, then assembled in the outer membrane by Mim1p; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YIL137C
symbol: TMA108
gene_biotype: protein_coding
description:
  Protein TMA108; Ribosome-associated, nascent chain binding factor; binds N-terminal region of nascent peptides during translation; recognizes target proteins via its putative metallopeptidase peptide-binding pocket.


ensembl_gene_id: YIL138C
symbol: TPM2
gene_biotype: protein_coding
description:
  Tropomyosin-2; Minor isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; appears to have distinct and also overlapping functions with Tpm1p; TPM2 has a paralog, TPM1, that arose from the whole genome duplication.


ensembl_gene_id: YIL139C
symbol: REV7
gene_biotype: protein_coding
description:
  Accessory subunit of DNA polymerase zeta; involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair; forms a complex with Rev3p, Pol31p and Pol32p; Belongs to the MAD2 family.


ensembl_gene_id: YIL140W
symbol: AXL2
gene_biotype: protein_coding
description:
  Integral plasma membrane protein; required for axial budding in haploid cells; localizes to the incipient bud site and bud neck; glycosylated by Pmt4p; potential Cdc28p substrate.


ensembl_gene_id: YIL141W
symbol: YIL141W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YIL141W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YIL142C-A
symbol: YIL142C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YIL142C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF CCT2/YIL142W.


ensembl_gene_id: YIL142W
symbol: CCT2
gene_biotype: protein_coding
description:
  T-complex protein 1 subunit beta; Subunit beta of the cytosolic chaperonin Cct ring complex; related to Tcp1p, required for the assembly of actin and tubulins in vivo.


ensembl_gene_id: YIL143C
symbol: SSL2
gene_biotype: protein_coding
description:
  General transcription and DNA repair factor IIH helicase subunit XPB; Component of RNA polymerase transcription factor TFIIH holoenzyme; acts as dsDNA-dependent translocase in context of TFIIH, unwinds DNA strands during initiation and promotes transcription start site (TSS) scanning; has DNA-dependent ATPase/helicase activity; interacts functionally with TFIIB, has roles in TSS selection and gene looping to juxtapose initiation and termination regions; involved in DNA repair; relocalizes to cytosol under hypoxia; homolog of human ERCC3; Belongs to the helicase family. RAD25/XPB subfamily.


ensembl_gene_id: YIL144W
symbol: NDC80
gene_biotype: protein_coding
description:
  Component of the kinetochore-associated Ndc80 complex; conserved coiled-coil protein involved in chromosome segregation, spindle checkpoint activity, and kinetochore assembly and clustering; evolutionarily conserved; complex members include Ndc80p, Nuf2p, Scp24p, and Spc25p; modified by sumoylation.


ensembl_gene_id: YIL145C
symbol: PAN6
gene_biotype: protein_coding
description:
  Pantoate--beta-alanine ligase; Pantothenate synthase; also known as pantoate-beta-alanine ligase, required for pantothenic acid biosynthesis, deletion causes pantothenic acid auxotrophy, homologous to E. coli panC.


ensembl_gene_id: YIL146C
symbol: ATG32
gene_biotype: protein_coding
description:
  Autophagy-related protein 32; Mitochondrial outer membrane protein required to initiate mitophagy; recruits the autophagy adaptor protein Atg11p and the ubiquitin-like protein Atg8p to the mitochondrial surface to initiate mitophagy, the selective vacuolar degradation of mitochondria in response to starvation; can promote pexophagy when placed ectopically in the peroxisomal membrane; regulates mitophagy and ethanol production during alcoholic fermentation.


ensembl_gene_id: YIL147C
symbol: SLN1
gene_biotype: protein_coding
description:
  Osmosensing histidine protein kinase SLN1; Transmembrane histidine phosphotransfer kinase and osmosensor; regulates MAP kinase cascade; transmembrane protein with an intracellular kinase domain that signals to Ypd1p and Ssk1p, thereby forming a phosphorelay system similar to bacterial two-component regulators.


ensembl_gene_id: YIL148W
symbol: RPL40A
gene_biotype: protein_coding
description:
  Ubiquitin-ribosomal 60S subunit protein L40A fusion protein; cleaved to yield ubiquitin and ribosomal protein L40A; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40A has a paralog, RPL40B, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress.


ensembl_gene_id: YIL149C
symbol: MLP2
gene_biotype: protein_coding
description:
  Myosin-like protein associated with the nuclear envelope; nuclear basket protein that connects the nuclear pore complex with the nuclear interior; involved in the Tel1p pathway that controls telomere length; MLP2 has a paralog, MLP1, that arose from the whole genome duplication.


ensembl_gene_id: YIL150C
symbol: MCM10
gene_biotype: protein_coding
description:
  Minichromosome maintenance protein 10; Essential chromatin-associated protein; involved in initiation of DNA replication; required for association of MCM2-7 complex with replication origins; required to stabilize catalytic subunit of DNA polymerase-alpha; self-associates through its N-terminal domain.


ensembl_gene_id: YIL151C
symbol: ESL1
gene_biotype: protein_coding
description:
  hEST1A/B (SMG5/6)-like protein; contributes to environment-sensing adaptive gene expression responses; Esl1p and Esl2p contain a 14-3-3-like domain and a putative PilT N-terminus ribonuclease domain; ESL1 has a paralog, ESL2, that arose from the whole genome duplication.


ensembl_gene_id: YIL153W
symbol: RRD1
gene_biotype: protein_coding
description:
  Peptidyl-prolyl cis/trans-isomerase; activator of the phosphotyrosyl phosphatase activity of PP2A; involved in G1 phase progression, microtubule dynamics, bud morphogenesis and DNA repair; required for rapid reduction of Sgs1p levels in response to rapamycin; subunit of the Tap42p-Sit4p-Rrd1p complex; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; Belongs to the PTPA-type PPIase family.


ensembl_gene_id: YIL154C
symbol: IMP2
gene_biotype: protein_coding
description:
  Sugar utilization regulatory protein IMP2; Transcriptional activator involved in maintenance of ion homeostasis; also involved in protection against DNA damage caused by bleomycin and other oxidants; contains a C-terminal leucine-rich repeat.


ensembl_gene_id: YIL155C
symbol: GUT2
gene_biotype: protein_coding
description:
  Mitochondrial glycerol-3-phosphate dehydrogenase; expression is repressed by both glucose and cAMP and derepressed by non-fermentable carbon sources in a Snf1p, Rsf1p, Hap2/3/4/5 complex dependent manner.


ensembl_gene_id: YIL156W
symbol: UBP7
gene_biotype: protein_coding
description:
  Ubiquitin-specific protease that cleaves ubiquitin-protein fusions; UBP7 has a paralog, UBP11, that arose from the whole genome duplication.


ensembl_gene_id: YIL156W-A
symbol: YIL156W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized membrane protein YIL156W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF COA1/YIL157C.


ensembl_gene_id: YIL156W-B
symbol: YIL156W-B
gene_biotype: protein_coding
description:
  Uncharacterized protein YIL156W-B; Putative protein of unknown function; originally identified based on homology to <i>Ashbya gossypii</i> and other related yeasts; SWAT-GFP and mCherry fusion proteins localize to the vacuole, while SWAT-GFP fusion also localizes to the endoplasmic reticulum.


ensembl_gene_id: YIL157C
symbol: COA1
gene_biotype: protein_coding
description:
  Cytochrome c oxidase assembly factor 1; Mitochondrial inner membrane protein; required for assembly of the cytochrome c oxidase complex (complex IV); interacts with complex IV assembly factor Shy1p during the early stages of assembly.


ensembl_gene_id: YIL158W
symbol: AIM20
gene_biotype: protein_coding
description:
  Altered inheritance of mitochondria protein 20; Protein of unknown function; overexpression causes cell cycle delay or arrest; green fluorescent protein (GFP)-fusion protein localizes to vacuole; null mutant displays elevated frequency of mitochondrial genome loss; relocalizes from nucleus to cytoplasm upon DNA replication stress; AIM20 has a paralog, SKG1, that arose from the whole genome duplication.


ensembl_gene_id: YIL159W
symbol: BNR1
gene_biotype: protein_coding
description:
  BNI1-related protein 1; Formin; nucleates the formation of linear actin filaments; involved in processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables; activity is regulated by Hof1p and by the Bud14p-Kel1p-Kel2p complex; dephosphorylated and delocalized from the division site in a Glc7p/Ref2p-dependent manner; functionally redundant with BNI1.


ensembl_gene_id: YIL160C
symbol: POT1
gene_biotype: protein_coding
description:
  3-ketoacyl-CoA thiolase, peroxisomal; 3-ketoacyl-CoA thiolase with broad chain length specificity; cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids.


ensembl_gene_id: YIL161W
symbol: YIL161W
gene_biotype: protein_coding
description:
  Uncharacterized protein YIL161W; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; mRNA is enriched in Scp160p-associated mRNPs; YIL161W is a non-essential gene.


ensembl_gene_id: YIL162W
symbol: SUC2
gene_biotype: protein_coding
description:
  Invertase; sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively.


ensembl_gene_id: YIL163C
symbol: YIL163C
gene_biotype: protein_coding
description:
  Uncharacterized protein YIL163C; Protein of unknown function; mRNA identified as translated by ribosome profiling data.


ensembl_gene_id: YIL164C
symbol: NIT1
gene_biotype: protein_coding
description:
  Putative nitrilase-like protein NIT1; Nitrilase; member of the nitrilase branch of the nitrilase superfamily; in closely related species and other S. cerevisiae strain backgrounds YIL164C and adjacent ORF, YIL165C, likely constitute a single ORF encoding a nitrilase gene; Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.


ensembl_gene_id: YIL165C
symbol: YIL165C
gene_biotype: protein_coding
description:
  Putative protein of unknown function; mutant exhibits mitophagy defects; in closely related species and other S. cerevisiae strain backgrounds YIL165C and adjacent ORF, YIL164C, likely constitute a single ORF encoding a nitrilase gene; Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.


ensembl_gene_id: YIL166C
symbol: YIL166C
gene_biotype: protein_coding
description:
  Uncharacterized transporter YIL166C; Putative protein with similarity to allantoate permease; similar to the allantoate permease (Dal5p) subfamily of the major facilitator superfamily; mRNA expression is elevated by sulfur limitation; YIL166C is a non-essential gene.


ensembl_gene_id: YIL169C
symbol: CSS1
gene_biotype: protein_coding
description:
  Protein of unknown function, secreted when constitutively expressed; SWAT-GFP, seamless-GFP and mCherry fusion proteins localize to the cell periphery, SWAT-GFP fusion also localizes to the extracellular region, and mCherry fusion also localizes to the vacuole; S/T rich and highly similar to YOL155C, a putative glucan alpha-1,4-glucosidase; transcript is induced in both high and low pH environments; non-essential gene; Belongs to the SRP1/TIP1 family.


ensembl_gene_id: YIL171W-A
symbol: YIL171W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized membrane protein YIL171W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF IMA3/YIL172C.


ensembl_gene_id: YIL172C
symbol: IMA3
gene_biotype: protein_coding
description:
  Oligo-1,6-glucosidase IMA3; Alpha-glucosidase; weak, but broad substrate specificity for alpha-1,4- and alpha-1,6-glucosides; member of IMA isomaltase family; not required for isomaltose utilization, but Ima3p overexpression allows the ima1 null mutant to grow on isomaltose; lower activitiy and thermostability in vitro than Ima2p despite sequence difference of only 3 amino acids; cleaves alpha-1,3 linkage of nigerose and turanose, but not alpha-1,5 of leucrose; identical to IMA4; Belongs to the glycosyl hydrolase 13 family.


ensembl_gene_id: YIL173W
symbol: VTH1
gene_biotype: protein_coding
description:
  VPS10 homolog 1; Putative membrane glycoprotein; has strong similarity to Vth2p and Pep1p/Vps10p; may be involved in vacuolar protein sorting.


ensembl_gene_id: YIL176C
symbol: PAU14
gene_biotype: protein_coding
description:
  Seripauperin-14; Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions; identical to Pau1p; Belongs to the SRP1/TIP1 family. Seripauperin subfamily.


ensembl_gene_id: YIL177W-A
symbol: YIL177W-A
gene_biotype: protein_coding
description:
  Putative UPF0479 protein YJL225W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the uncharacterized gene YIL177C; Belongs to the UPF0479 family.


ensembl_gene_id: YIR001C
symbol: SGN1
gene_biotype: protein_coding
description:
  Cytoplasmic RNA-binding protein; contains an RNA recognition motif (RRM); may have a role in mRNA translation, as suggested by genetic interactions with genes encoding proteins involved in translational initiation.


ensembl_gene_id: YIR002C
symbol: MPH1
gene_biotype: protein_coding
description:
  3'-5' DNA helicase involved in error-free bypass of DNA lesions; binds flap DNA, stimulates activity of Rad27p and Dna2p; prevents crossovers between ectopic sequences by removing substrates for Mus81-Mms4 or Rad1-Rad10 cleavage; homolog of human FANCM Fanconi anemia protein that is involved in stabilizing and remodeling blocked replication forks; member of SF2 DExD/H superfamily of helicases; nonsense or missense mutations in FANCM can make people more likely to get cancer.


ensembl_gene_id: YIR003W
symbol: AIM21
gene_biotype: protein_coding
description:
  Protein of unknown function; involved in mitochondrial migration along actin filament; may interact with ribosomes; GFP-fusion protein colocalizes with Sac1p to the actin cytoskeleton; Belongs to the AIM21 family.


ensembl_gene_id: YIR004W
symbol: DJP1
gene_biotype: protein_coding
description:
  DnaJ-like protein 1; Cytosolic J-domain-containing protein; required for peroxisomal protein import and involved in peroxisome assembly; facilitates import of Mim1p and Mim2p into the mitochondrial outer membrane; homologous to E. coli DnaJ.


ensembl_gene_id: YIR005W
symbol: IST3
gene_biotype: protein_coding
description:
  Component of the U2 snRNP; required for the first catalytic step of splicing and for spliceosomal assembly; interacts with Rds3p and is required for Mer1p-activated splicing; diploid mutants have a specific defect in MATa1 pre-mRNA splicing which leads to haploid gene expression in diploids; Belongs to the IST3 family.


ensembl_gene_id: YIR006C
symbol: PAN1
gene_biotype: protein_coding
description:
  Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p; associates with actin patches on cell cortex; promotes protein-protein interactions essential for endocytosis; binds to and activates Arp2/3 complex in vitro; phosphorylation of Thr-1225 is regulated by MAPK Hog1p in response to osmotic stress; previously thought to be a subunit of poly(A) ribonuclease.


ensembl_gene_id: YIR007W
symbol: EGH1
gene_biotype: protein_coding
description:
  Ergosteryl-beta-glucosidase; Steryl-beta-glucosidase with broad specificity for aglycones; has a role in ergosteryl-beta-glucoside catabolism; required for normal vacuolar morphology; has similarity to the C. neoformans ergosteryl-beta-glucosidase EGCrP2; localizes to the cytosol.


ensembl_gene_id: YIR008C
symbol: PRI1
gene_biotype: protein_coding
description:
  Subunit of DNA primase; DNA primase is required for DNA synthesis and double-strand break repair; Belongs to the eukaryotic-type primase small subunit family.


ensembl_gene_id: YIR009W
symbol: MSL1
gene_biotype: protein_coding
description:
  U2 small nuclear ribonucleoprotein B'; U2B component of U2 snRNP; involved in splicing, binds the U2 snRNA stem-loop IV in vitro but requires association of Lea1p for in vivo binding; does not contain the conserved C-terminal RNA binding domain found in other family members.


ensembl_gene_id: YIR010W
symbol: DSN1
gene_biotype: protein_coding
description:
  Kinetochore-associated protein DSN1; Essential component of the MIND kinetochore complex; joins kinetochore subunits contacting DNA to those contacting microtubules; Dsn1p phosphorylation promotes interaction between outer and inner kinetochore proteins; kinetochore receptor for monopolin, via interaction with subunit Csm1p; essential for meiotic but not mitotic chromosome segregation; MIND complex consists of Mtw1p, Nnf1p, Nsl1p and Dsn1p; modified by sumoylation; phosphorylated by monopolin subunit Hrr25p.


ensembl_gene_id: YIR011C
symbol: STS1
gene_biotype: protein_coding
description:
  Tethering factor for nuclear proteasome STS1; Protein required for localizing proteasomes to the nucleus; involved in cotranslational protein degradation; mediates interaction between nuclear import factor Srp1p and the proteasome; Sts1p and Srp1p couple proteasomes to nascent polypeptides emerging from the ribosome for cotranslational degradation; involved in ubiquitin-mediated protein degradation; Belongs to the cut8/STS1 family.


ensembl_gene_id: YIR012W
symbol: SQT1
gene_biotype: protein_coding
description:
  Ribosome assembly protein SQT1; Specific chaperone for ribosomal protein Rpl10p; binds nascent Rpl10p during translation; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YIR013C
symbol: GAT4
gene_biotype: protein_coding
description:
  Protein containing GATA family zinc finger motifs; involved in spore wall assembly; sequence similarity to GAT3, and the double mutant gat3 gat4 exhibits reduced dityrosine fluorescence relative to the single mutants.


ensembl_gene_id: YIR014W
symbol: YIR014W
gene_biotype: protein_coding
description:
  Vacuole localized DSC protein 1; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; YIR014W is a non-essential gene.


ensembl_gene_id: YIR015W
symbol: RPR2
gene_biotype: protein_coding
description:
  Ribonuclease P protein subunit RPR2; Subunit of nuclear RNase P; nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; not shared between RNase MRP and RNase P, in contrast to all other RNase P protein subunits; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YIR016W
symbol: YIR016W
gene_biotype: protein_coding
description:
  Uncharacterized protein YIR016W; Putative protein of unknown function; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; overexpression causes a cell cycle delay or arrest; non-essential gene; YIR016W has a paralog, YOL036W, that arose from the whole genome duplication.


ensembl_gene_id: YIR017C
symbol: MET28
gene_biotype: protein_coding
description:
  bZIP transcriptional activator in the Cbf1p-Met4p-Met28p complex; participates in the regulation of sulfur metabolism.


ensembl_gene_id: YIR017W-A
symbol: YIR017W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YIR017W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YIR018C-A
symbol: YIR018C-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YIR018C-A; Putative protein of unknown function; identified by expression profiling and mass spectrometry.


ensembl_gene_id: YIR018W
symbol: YAP5
gene_biotype: protein_coding
description:
  Basic leucine zipper (bZIP) iron-sensing transcription factor; involved in diauxic shift; YAP5 has a paralog, YAP7, that arose from the whole genome duplication.


ensembl_gene_id: YIR019C
symbol: FLO11
gene_biotype: protein_coding
description:
  Flocculation protein FLO11; GPI-anchored cell surface glycoprotein (flocculin); required for pseudohyphal and invasive growth, flocculation, and biofilm formation; major determinant of colony morphology; transcription regulated by the MAPK pathway (Ste12p and Tec1p) and the cAMP pathway (Flo8p); required for formation of fibrous interconnections between cells of a wild strain; role in co-flocculation with other yeast species; cleaved and shed from cells, contributing to their surface properties; Belongs to the flocculin family. Highly divergent.


ensembl_gene_id: YIR020C
symbol: YIR020C
gene_biotype: protein_coding
description:
  Uncharacterized protein YIR020C; Protein of unknown function; mRNA identified as translated by ribosome profiling data; SWAT-GFP fusion protein localizes to the endoplasmic reticulum.


ensembl_gene_id: YIR020C-B
symbol: YIR020C-B
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YIR020C-B; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified ORF MRS1.


ensembl_gene_id: YIR020W-A
symbol: YIR020W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YIR020W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YIR021W
symbol: MRS1
gene_biotype: protein_coding
description:
  Splicing protein; required for splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA; MRS1 has a paralog, CCE1, that arose from the whole genome duplication.


ensembl_gene_id: YIR021W-A
symbol: YIR021W-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YIR021W-A; Putative protein of unknown function; identified by expression profiling and mass spectrometry.


ensembl_gene_id: YIR022W
symbol: SEC11
gene_biotype: protein_coding
description:
  18kDa catalytic subunit of the Signal Peptidase Complex (SPC); the Signal Peptidase Complex cleaves the signal sequence of proteins targeted to the endoplasmic reticulum; other members are Spc1p, Spc2p, Spc3p, and Sec11p.


ensembl_gene_id: YIR023C-A
symbol: YIR023C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized membrane protein YIR023C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF DAL81/YIR023W.


ensembl_gene_id: YIR023W
symbol: DAL81
gene_biotype: protein_coding
description:
  Transcriptional activator protein DAL81; Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism.


ensembl_gene_id: YIR024C
symbol: INA22
gene_biotype: protein_coding
description:
  Inner membrane assembly complex subunit 22; F1F0 ATP synthase peripheral stalk assembly factor; subunit of the matrix-exposed inner mitochondrial membrane localized INA complex (Ina22p-Ina17p) involved in assembly of the F1F0 peripheral stalk; co-purifies with Aim43p, ATP synthase subunits, and cytochrome bc1 complex assembly factors; interacts with Arh1p, a mitochondrial oxidoreductase; deletion mutant has a respiratory growth defect.


ensembl_gene_id: YIR025W
symbol: MND2
gene_biotype: protein_coding
description:
  Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); necessary for maintaining sister chromatid cohesion in prophase I of meiosis by inhibiting premature ubiquitination and subsequent degradation of substrates by the APC(Ama1) ubiquitin ligase; Belongs to the APC15 family.


ensembl_gene_id: YIR026C
symbol: YVH1
gene_biotype: protein_coding
description:
  Tyrosine-protein phosphatase YVH1; Dual specificity protein phosphatase; regulates growth, sporulation, and glycogen accumulation in a cAMP-dependent protein kinase cascade dependent manner; mutants are defective in 60S ribosome assembly; positively regulates pre-autophagosomal structure (PAS) formation upon nitrogen starvation or rapamycin treatment.


ensembl_gene_id: YIR027C
symbol: DAL1
gene_biotype: protein_coding
description:
  Allantoinase; converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression; Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family.


ensembl_gene_id: YIR028W
symbol: DAL4
gene_biotype: protein_coding
description:
  Allantoin permease; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation; Belongs to the purine-cytosine permease (2.A.39) family.


ensembl_gene_id: YIR029W
symbol: DAL2
gene_biotype: protein_coding
description:
  Allantoicase; converts allantoate to urea and ureidoglycolate in the second step of allantoin degradation; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation.


ensembl_gene_id: YIR030C
symbol: DCG1
gene_biotype: protein_coding
description:
  Protein of unknown function; expression is sensitive to nitrogen catabolite repression and regulated by Dal80p; contains transmembrane domain; Belongs to the HyuE racemase family.


ensembl_gene_id: YIR030W-A
symbol: YIR030W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YIR030W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF DAL7/YIR031C.


ensembl_gene_id: YIR031C
symbol: DAL7
gene_biotype: protein_coding
description:
  Malate synthase; can accept butyryl-CoA as acyl-CoA donor in addition to traditional substrate acetyl-CoA; recycles glyoxylate generated during allantoin degradation; SWAT-GFP and mCherry fusion proteins localize to the cytosol; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation.


ensembl_gene_id: YIR032C
symbol: DAL3
gene_biotype: protein_coding
description:
  Ureidoglycolate lyase; converts ureidoglycolate to glyoxylate and urea in the third step of allantoin degradation; expression is sensitive to nitrogen catabolite repression; this enzyme is sometimes referred to ureidoglycolate hydrolase but should not be confused with the Arabidopsis thaliana ureidoglycolate hydrolase enzyme which converts ureidoglycolate to glyoxylate, ammonia and carbon dioxide.


ensembl_gene_id: YIR033W
symbol: MGA2
gene_biotype: protein_coding
description:
  ER membrane protein involved in regulation of OLE1 transcription; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting; MGA2 has a paralog, SPT23, that arose from the whole genome duplication.


ensembl_gene_id: YIR034C
symbol: LYS1
gene_biotype: protein_coding
description:
  Saccharopine dehydrogenase (NAD+, L-lysine-forming); catalyzes the conversion of saccharopine to L-lysine, which is the final step in the lysine biosynthesis pathway; also has mRNA binding activity; Belongs to the AlaDH/PNT family.


ensembl_gene_id: YIR036C
symbol: IRC24
gene_biotype: protein_coding
description:
  Benzil reductase ((S)-benzoin forming) IRC24; Putative benzil reductase;(GFP)-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS; sequence similarity with short-chain dehydrogenase/reductases; null mutant has increased spontaneous Rad52p foci; Belongs to the short-chain dehydrogenases/reductases (SDR) family.


ensembl_gene_id: YIR036W-A
symbol: YIR036W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized membrane protein YIR036W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF IRC24/YIR036C.


ensembl_gene_id: YIR037W
symbol: HYR1
gene_biotype: protein_coding
description:
  Glutathione peroxidase-like peroxiredoxin HYR1; Thiol peroxidase; functions as a hydroperoxide receptor to sense intracellular hydroperoxide levels and transduce a redox signal to the Yap1p transcription factor; HYR1 has a paralog, GPX1, that arose from the whole genome duplication.


ensembl_gene_id: YIR038C
symbol: GTT1
gene_biotype: protein_coding
description:
  ER associated glutathione S-transferase; capable of homodimerization; glutathione transferase for Yvc1p vacuolar cation channel; expression induced during the diauxic shift and throughout stationary phase; functional overlap with Gtt2p, Grx1p, and Grx2p.


ensembl_gene_id: YIR039C
symbol: YPS6
gene_biotype: protein_coding
description:
  Aspartic proteinase yapsin-6; Putative GPI-anchored aspartic protease; member of the yapsin family of proteases involved in cell wall growth and maintenance.


ensembl_gene_id: YIR040C
symbol: YIR040C
gene_biotype: protein_coding
description:
  Putative UPF0377 protein YIR040C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; Belongs to the UPF0377 family.


ensembl_gene_id: YIR041W
symbol: PAU15
gene_biotype: protein_coding
description:
  Seripauperin-15; Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions; SWAT-GFP and mCherry fusion proteins localize to the vacuole; Belongs to the SRP1/TIP1 family. Seripauperin subfamily.


ensembl_gene_id: YJL002C
symbol: OST1
gene_biotype: protein_coding
description:
  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1; Alpha subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes asparagine-linked glycosylation of newly synthesized proteins; Belongs to the OST1 family.


ensembl_gene_id: YJL004C
symbol: SYS1
gene_biotype: protein_coding
description:
  Protein SYS1; Integral membrane protein of the Golgi; required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation.


ensembl_gene_id: YJL005W
symbol: CYR1
gene_biotype: protein_coding
description:
  Adenylate cyclase; required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation.


ensembl_gene_id: YJL006C
symbol: CTK2
gene_biotype: protein_coding
description:
  Beta subunit of C-terminal domain kinase I (CTDK-I); which phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity; relocalizes to the cytosol in response to hypoxia.


ensembl_gene_id: YJL007C
symbol: YJL007C
gene_biotype: protein_coding
description:
  Uncharacterized protein YJL007C; Putative protein of unknown function; conserved among S. cerevisiae strains.


ensembl_gene_id: YJL008C
symbol: CCT8
gene_biotype: protein_coding
description:
  T-complex protein 1 subunit theta; Subunit of the cytosolic chaperonin Cct ring complex; related to Tcp1p, required for the assembly of actin and tubulins in vivo.


ensembl_gene_id: YJL009W
symbol: YJL009W
gene_biotype: protein_coding
description:
  Uncharacterized protein YJL009W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps CCT8/YJL008C, a verified gene encoding a subunit of the cytosolic chaperonin Cct ring complex.


ensembl_gene_id: YJL010C
symbol: NOP9
gene_biotype: protein_coding
description:
  Nucleolar protein 9; Essential subunit of U3-containing 90S preribosome; involved in production of 18S rRNA and assembly of small ribosomal subunit; also part of pre-40S ribosome and required for its export into cytoplasm; binds RNA and contains pumilio domain; Belongs to the NOP9 family.


ensembl_gene_id: YJL011C
symbol: RPC17
gene_biotype: protein_coding
description:
  RNA polymerase III subunit C17; physically interacts with C31, C11, and TFIIIB70; may be involved in the recruitment of pol III by the preinitiation complex; protein abundance increases in response to DNA replication stress; relocalizes to the cytosol in response to hypoxia.


ensembl_gene_id: YJL012C
symbol: VTC4
gene_biotype: protein_coding
description:
  Vacuolar transporter chaperone 4; Vacuolar membrane polyphosphate polymerase; subunit of the vacuolar transporter chaperone (VTC) complex involved in synthesis and transfer of polyP to the vacuole; regulates membrane trafficking; role in non-autophagic vacuolar fusion; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YJL013C
symbol: MAD3
gene_biotype: protein_coding
description:
  Subunit of spindle-assembly checkpoint complex; involved in delaying anaphase onset in cells with defects in mitotic spindle assembly; pseudosubstrate inhibitor of APC(Cdc20), the anaphase promoting complex involved in securin (Pds1p) turnover; MAD3 has a paralog, BUB1, that arose from the whole genome duplication.


ensembl_gene_id: YJL014W
symbol: CCT3
gene_biotype: protein_coding
description:
  T-complex protein 1 subunit gamma; Subunit of the cytosolic chaperonin Cct ring complex; related to Tcp1p, required for the assembly of actin and tubulins in vivo; capable of binding Q/N rich proteins and mediating their folding.


ensembl_gene_id: YJL015C
symbol: YJL015C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YJL015C; Dubious open reading frame unlikely to encode a functional protein; expression if heat-inducible; located in promoter region of essential CCT3 gene encoding a subunit of the cytosolic chaperonin Cct ring complex, overlaps ORF YJL016W.


ensembl_gene_id: YJL016W
symbol: TPH3
gene_biotype: protein_coding
description:
  Uncharacterized protein YJL016W; Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; contains two adjacent PH-like domains; conserved in closely related Saccharomyces species.


ensembl_gene_id: YJL019W
symbol: MPS3
gene_biotype: protein_coding
description:
  Spindle pole body assembly component MPS3; Nuclear envelope protein; required for SPB insertion, SPB duplication, Kar5p localization near the SPB and nuclear fusion; interacts with Mps2p to tether half-bridge to core SPB; N-terminal acetylation by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; member of the SUN protein family (Sad1-UNC-84 homology).


ensembl_gene_id: YJL020C
symbol: BBC1
gene_biotype: protein_coding
description:
  Myosin tail region-interacting protein MTI1; Protein possibly involved in assembly of actin patches; interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3p and Myo5p; localized predominantly to cortical actin patches.


ensembl_gene_id: YJL020W-A
symbol: YJL020W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YJL020W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL020C/BBC1.


ensembl_gene_id: YJL022W
symbol: YJL022W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YJL009W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130.


ensembl_gene_id: YJL023C
symbol: PET130
gene_biotype: protein_coding
description:
  Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies.


ensembl_gene_id: YJL024C
symbol: APS3
gene_biotype: protein_coding
description:
  AP-3 complex subunit sigma; Small subunit of the clathrin-associated adaptor complex AP-3; involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YJL025W
symbol: RRN7
gene_biotype: protein_coding
description:
  RNA polymerase I-specific transcription initiation factor RRN7; Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p; Belongs to the RRN7/TAF1B family.


ensembl_gene_id: YJL026C-A
symbol: YJL026C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YJL026C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL026W/RNR2.


ensembl_gene_id: YJL026W
symbol: RNR2
gene_biotype: protein_coding
description:
  Ribonucleoside-diphosphate reductase small chain 1; Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits; RNR2 has a paralog, RNR4, that arose from the whole genome duplication; Belongs to the ribonucleoside diphosphate reductase small chain family.


ensembl_gene_id: YJL028W
symbol: YJL028W
gene_biotype: protein_coding
description:
  Uncharacterized protein YJL028W; Protein of unknown function; may interact with ribosomes, based on co-purification experiments.


ensembl_gene_id: YJL029C
symbol: VPS53
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 53; Component of the GARP (Golgi-associated retrograde protein) complex; GARP is required for the recycling of proteins from endosomes to the late Golgi, and for mitosis after DNA damage induced checkpoint arrest; required for vacuolar protein sorting; members of the GARP complex are Vps51p-Vps52p-Vps53p-Vps54p; human ortholog is implicated in progressive cerebello-cerebral atrophy type 2 (PCCA2).


ensembl_gene_id: YJL030W
symbol: MAD2
gene_biotype: protein_coding
description:
  Component of the spindle-assembly checkpoint complex; delays onset of anaphase in cells with defects in mitotic spindle assembly; forms a complex with Mad1p; regulates APC/C activity during prometaphase and metaphase of meiosis I; gene dosage imbalance between MAD1 and MAD2 leads to chromosome instability.


ensembl_gene_id: YJL031C
symbol: BET4
gene_biotype: protein_coding
description:
  Alpha subunit of Type II geranylgeranyltransferase; required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p.


ensembl_gene_id: YJL032W
symbol: YJL032W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YJL032W; Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential BET4 gene encoding the alpha subunit of Type II geranylgeranyltransferase.


ensembl_gene_id: YJL033W
symbol: HCA4
gene_biotype: protein_coding
description:
  DEAD box RNA helicase; component of the SSU; interacts with Bfr2p and Enp2p; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis; Belongs to the DEAD box helicase family. DDX10/DBP4 subfamily.


ensembl_gene_id: YJL034W
symbol: KAR2
gene_biotype: protein_coding
description:
  Endoplasmic reticulum chaperone BiP; ATPase involved in protein import into the ER; also acts as a chaperone to mediate protein folding in the ER and may play a role in ER export of soluble proteins; regulates the unfolded protein response via interaction with Ire1p.


ensembl_gene_id: YJL035C
symbol: TAD2
gene_biotype: protein_coding
description:
  Subunit of tRNA-specific adenosine-34 deaminase; forms a heterodimer with Tad3p that converts adenosine to inosine at the wobble position of several tRNAs; Belongs to the cytidine and deoxycytidylate deaminase family. ADAT2 subfamily.


ensembl_gene_id: YJL036W
symbol: SNX4
gene_biotype: protein_coding
description:
  Sorting nexin; involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans-Golgi network and in cytoplasm to vacuole transport; contains a PX phosphoinositide-binding domain; forms complexes with Snx41p and with Atg20p.


ensembl_gene_id: YJL037W
symbol: IRC18
gene_biotype: protein_coding
description:
  Protein involved in outer spore wall assembly; possible role in assembly of the dityrosine layer; similar to adjacent ORF, LOH1; irc18 loh1 double mutant exhibits reduced dityrosine fluorescence relative to single mutants; SWAT-GFP fusion protein localizes to the ER and vacuole, while mCherry fusion localizes to the vacuole; expression induced in respiratory-deficient cells and carbon-limited chemostat culture; null mutant displays increased levels of spontaneous Rad52p foci; Belongs to the OSW4/6 family.


ensembl_gene_id: YJL038C
symbol: LOH1
gene_biotype: protein_coding
description:
  Protein involved in outer spore wall assembly; likely involved directly in dityrosine layer assembly; induced during sporulation; repressed during vegetative growth by Sum1p and Hst1p; sequence similar to adjacent ORF, IRC18/YJL037W, and the irc18 loh1 double mutant exhibits reduced dityrosine fluorescence relative to the single mutants; SWAT-GFP and mCherry fusion proteins localize to the cytosol; proposed role in maintenance of genome integrity.


ensembl_gene_id: YJL039C
symbol: NUP192
gene_biotype: protein_coding
description:
  Nucleoporin NUP192; Essential subunit of inner ring of nuclear pore complex (NPC); plays a role in modulating transport through the NPC; homologous to human NUP205.


ensembl_gene_id: YJL041W
symbol: NSP1
gene_biotype: protein_coding
description:
  FG-nucleoporin component of central core of the nuclear pore complex; also part of the nuclear pore complex (NPC) nuclear basket; contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nup82p, Gle2p and two other FG-nucleoporins (Nup159p and Nup116p); also found in stable complex with Nic96p and two other FG-nucleoproteins (Nup49p and Nup57p).


ensembl_gene_id: YJL042W
symbol: MHP1
gene_biotype: protein_coding
description:
  MAP-homologous protein 1; Microtubule-associated protein involved in microtubule organization; involved in assembly and stabilization of microtubules; overproduction results in cell cycle arrest at G2 phase; similar to Drosophila protein MAP and to mammalian MAP4 proteins.


ensembl_gene_id: YJL044C
symbol: GYP6
gene_biotype: protein_coding
description:
  GTPase-activating protein (GAP) for yeast Rab family member Ypt6p; involved in vesicle mediated protein transport.


ensembl_gene_id: YJL045W
symbol: YJL045W
gene_biotype: protein_coding
description:
  Succinate dehydrogenase [ubiquinone] flavoprotein subunit 2, mitochondrial; Minor succinate dehydrogenase isozyme; participates in oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner; YJL045W has a paralog, SDH1, that arose from the whole genome duplication.


ensembl_gene_id: YJL046W
symbol: AIM22
gene_biotype: protein_coding
description:
  Putative lipoate-protein ligase; required along with Lip2 and Lip5 for lipoylation of Lat1p and Kgd2p; similar to E. coli LplA; null mutant displays reduced frequency of mitochondrial genome loss; Belongs to the LplA family.


ensembl_gene_id: YJL047C
symbol: RTT101
gene_biotype: protein_coding
description:
  Cullin-8; Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex; role in anaphase progression; required for recovery after DSB repair; implicated in Mms22-dependent DNA repair; involved with Mms1p in nonfunctional rRNA decay; modified by the ubiquitin-like protein, Rub1p.


ensembl_gene_id: YJL048C
symbol: UBX6
gene_biotype: protein_coding
description:
  UBX (ubiquitin regulatory X) domain-containing protein; interacts with Cdc48p, transcription is repressed when cells are grown in media containing inositol and choline; UBX6 has a paralog, UBX7, that arose from the whole genome duplication.


ensembl_gene_id: YJL049W
symbol: CHM7
gene_biotype: protein_coding
description:
  Uncharacterized protein YJL049W; Yeast homolog of human CHMP7, localizes to the endoplasmic reticulum presumably as part of an ESCRT-III like complex; null mutant has growth defect at 37 C in an apq12 deletion background; non-essential gene.


ensembl_gene_id: YJL050W
symbol: MTR4
gene_biotype: protein_coding
description:
  ATP-dependent 3'-5' RNA helicase of the DExD/H family; involved in nuclear RNA processing and degradation both as a component of TRAMP complex and in TRAMP-independent processes; TRAMP unwinds RNA duplexes, with Mtr4p unwinding activity stimulated by Pap2p/Air2p but not dependent on ongoing polyadenylation; contains an arch domain, with two coiled-coil arms/stalks and a globular fist/KOW domain, which has RNA binding activity and is required for 5.8S rRNA processing; Belongs to the helicase family. SKI2 subfamily.


ensembl_gene_id: YJL051W
symbol: IRC8
gene_biotype: protein_coding
description:
  Uncharacterized protein IRC8; Bud tip localized protein of unknown function; mRNA is targeted to the bud by a She2p dependent transport system; mRNA is cell cycle regulated via Fkh2p, peaking in G2/M phase; null mutant displays increased levels of spontaneous Rad52p foc.


ensembl_gene_id: YJL052C-A
symbol: YJL052C-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YJL052C-A; Putative protein of unknown function; identified based on comparison to related yeast species; mCherry fusion protein localizes to the vacuole.


ensembl_gene_id: YJL052W
symbol: TDH1
gene_biotype: protein_coding
description:
  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 1; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress; GAPDH-derived antimicrobial peptides secreted by S. cerevisiae are active against a wide variety of wine-related yeasts and bateria.


ensembl_gene_id: YJL053W
symbol: PEP8
gene_biotype: protein_coding
description:
  Carboxypeptidase Y-deficient protein 8; Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress; Belongs to the VPS26 family.


ensembl_gene_id: YJL054W
symbol: TIM54
gene_biotype: protein_coding
description:
  Mitochondrial import inner membrane translocase subunit TIM54; Component of the mitochondrial TIM22 complex; involved in insertion of polytopic proteins into the inner membrane.


ensembl_gene_id: YJL055W
symbol: YJL055W
gene_biotype: protein_coding
description:
  LOG family protein YJL055W; Putative protein of unknown function; functions together with HAM1 to mediate resistance to 5-FU; specifically reduces the incorporation of 5-FU into RNA, without affecting uptake or incorporation of uracil into RNA; proposed to be involved in the metabolism of purine and pyrimidine base analogues; deletion mutants are sensitive to HAP and AHA.


ensembl_gene_id: YJL056C
symbol: ZAP1
gene_biotype: protein_coding
description:
  Zinc-responsive transcriptional regulator ZAP1; Zinc-regulated transcription factor; binds to zinc-responsive promoters to induce transcription of certain genes in presence of zinc, represses other genes in low zinc; regulates its own transcription; contains seven zinc-finger domains.


ensembl_gene_id: YJL057C
symbol: IKS1
gene_biotype: protein_coding
description:
  Probable serine/threonine-protein kinase IKS1; Protein kinase of unknown cellular role; putative serine/threonine kinase; expression is induced during mild heat stress; deletion mutants are hypersensitive to copper sulphate and resistant to sorbate; interacts with an N-terminal fragment of Sst2p.


ensembl_gene_id: YJL058C
symbol: BIT61
gene_biotype: protein_coding
description:
  Subunit of TORC2 membrane-associated complex; involved in regulation of cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity; BIT61 has a paralog, BIT2, that arose from the whole genome duplication.


ensembl_gene_id: YJL059W
symbol: YHC3
gene_biotype: protein_coding
description:
  Protein required for the ATP-dependent transport of arginine; vacuolar membrane protein; involved in the ATP-dependent transport of arginine into the vacuole and possibly in balancing ion homeostasis; human homolog CLN3 involved in Batten disease (juvenile onset neuronal ceroid lipofuscinosis) can complement yeast null mutant; Belongs to the battenin family.


ensembl_gene_id: YJL060W
symbol: BNA3
gene_biotype: protein_coding
description:
  Probable kynurenine--oxoglutarate transaminase BNA3; Kynurenine aminotransferase; catalyzes formation of kynurenic acid from kynurenine; potential Cdc28p substrate.


ensembl_gene_id: YJL061W
symbol: NUP82
gene_biotype: protein_coding
description:
  Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins (Nsp1p, Nup159p, and Nup116p); relocalizes to the cytosol in response to hypoxia.


ensembl_gene_id: YJL062W
symbol: LAS21
gene_biotype: protein_coding
description:
  GPI ethanolamine phosphate transferase 2; Integral plasma membrane protein; involved in the synthesis of the glycosylphosphatidylinositol (GPI) core structure; mutations affect cell wall integrity.


ensembl_gene_id: YJL062W-A
symbol: COA3
gene_biotype: protein_coding
description:
  Mitochondrial protein required for cytochrome c oxidase assembly; also involved in translational regulation of Cox1p and prevention of Cox1p aggregation before assembly; located in the mitochondrial inner membrane.


ensembl_gene_id: YJL064W
symbol: YJL064W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YJL064W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL065C/DLS1.


ensembl_gene_id: YJL065C
symbol: DLS1
gene_biotype: protein_coding
description:
  Protein DLS1; Subunit of ISW2/yCHRAC chromatin accessibility complex; ISW2/yCHRAC also includes Itc1p, Isw2p, and Dpb4p; involved in inheritance of telomeric silencing; DLS1 has a paralog, DPB3, that arose from the whole genome duplication.


ensembl_gene_id: YJL067W
symbol: YJL067W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YJL067W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YJL068C
symbol: YJL068C
gene_biotype: protein_coding
description:
  Esterase that can function as an S-formylglutathione hydrolase; non-essential intracellular esterase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D.


ensembl_gene_id: YJL069C
symbol: UTP18
gene_biotype: protein_coding
description:
  Small-subunit processome protein involved in pre-18S rRNA maturation; part of a subunit of the 90S preribosomal particle capable of interacting directly with the 5' ETS of the 35S pre-rRNA; contains WD40 repeats.


ensembl_gene_id: YJL070C
symbol: YJL070C
gene_biotype: protein_coding
description:
  Inactive deaminase YJL070C; Putative metallo-dependent hydrolase superfamily protein; similar to AMP deaminases but lacks key catalytic residues and does not rescue purine nucleotide metabolic defect of quadruple aah1 ade8 amd1 his1 mutant; may regulate purine nucleotide homeostasis as overexpression in an AMD1 strain grown in adenine results in greatly reduced GDP and GTP intracellular levels; not an essential gene; YJL070C has a paralog, YBR284W, that arose from the whole genome duplication.


ensembl_gene_id: YJL071W
symbol: ARG2
gene_biotype: protein_coding
description:
  Amino-acid acetyltransferase, mitochondrial; Acetylglutamate synthase (glutamate N-acetyltransferase); mitochondrial enzyme that catalyzes the first step in the biosynthesis of the arginine precursor ornithine; forms a complex with Arg5,6p.


ensembl_gene_id: YJL072C
symbol: PSF2
gene_biotype: protein_coding
description:
  Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p); complex is localized to DNA replication origins and implicated in assembly of the DNA replication machinery; Belongs to the GINS2/PSF2 family.


ensembl_gene_id: YJL073W
symbol: JEM1
gene_biotype: protein_coding
description:
  DnaJ-like chaperone required for nuclear membrane fusion during mating; localizes to the ER membrane; exhibits genetic interactions with KAR2.


ensembl_gene_id: YJL074C
symbol: SMC3
gene_biotype: protein_coding
description:
  Structural maintenance of chromosomes protein 3; Subunit of the multiprotein cohesin complex; required for sister chromatid cohesion in mitotic cells; also required, with Rec8p, for cohesion and recombination during meiosis; phylogenetically conserved SMC chromosomal ATPase family member.


ensembl_gene_id: YJL075C
symbol: APQ13
gene_biotype: protein_coding
description:
  Putative uncharacterized protein APQ13; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the verified gene NET1; null mutant is sensitive to sorbate.


ensembl_gene_id: YJL076W
symbol: NET1
gene_biotype: protein_coding
description:
  Nucleolar protein NET1; Core subunit of the RENT complex; involved in nucleolar silencing and telophase exit; stimulates transcription by RNA polymerase I and regulates nucleolar structure; NET1 has a paralog, TOF2, that arose from the whole genome duplication; To yeast YKR010c.


ensembl_gene_id: YJL077C
symbol: ICS3
gene_biotype: protein_coding
description:
  Increased copper sensitivity protein 3; Protein with a role in copper homeostasis; possible role in vacuolar sorting and processing of secretory proteins; null mutants are hypersensitive to sortin2.


ensembl_gene_id: YJL077W-A
symbol: YJL077W-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YJL077W-A; Protein of unknown function; mRNA identified as translated by ribosome profiling data; completely overlaps the verified gene YJL077C/ICS3.


ensembl_gene_id: YJL077W-B
symbol: YJL077W-B
gene_biotype: protein_coding
description:
  Uncharacterized protein YJL077W-B; Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching.


ensembl_gene_id: YJL078C
symbol: PRY3
gene_biotype: protein_coding
description:
  Cell wall-associated protein involved in export of acetylated sterols; member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); role in mating efficiency; expression of full-length transcript is daughter cell-specific; in response to alpha factor, a short transcript starting at +452 is expressed and the long form is repressed by Ste12p.


ensembl_gene_id: YJL079C
symbol: PRY1
gene_biotype: protein_coding
description:
  Sterol binding protein involved in the export of acetylated sterols; secreted glycoprotein and member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); sterol export function is redundant with that of PRY2; may be involved in detoxification of hydrophobic compounds; PRY1 has a paralog, PRY2, that arose from the whole genome duplication.


ensembl_gene_id: YJL080C
symbol: SCP160
gene_biotype: protein_coding
description:
  Protein SCP160; Essential RNA-binding G protein effector of mating response pathway; ligand-activated RNA-binding protein that delivers RNAs involved in polarization and perpetualizing mating signal to shmoo tip during pheromone signaling; Scp160p-mediated RNA trafficking essential for chemotropism and successful mating; mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins.


ensembl_gene_id: YJL081C
symbol: ARP4
gene_biotype: protein_coding
description:
  Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes.


ensembl_gene_id: YJL082W
symbol: IML2
gene_biotype: protein_coding
description:
  Protein required for clearance of inclusion bodies; localizes to the inclusion bodies formed under protein misfolding stress; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; IML2 has a paralog, YKR018C, that arose from the whole genome duplication.


ensembl_gene_id: YJL083W
symbol: TAX4
gene_biotype: protein_coding
description:
  Protein TAX4; EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; TAX4 has a paralog, IRS4, that arose from the whole genome duplication.


ensembl_gene_id: YJL084C
symbol: ALY2
gene_biotype: protein_coding
description:
  Arrestin-related trafficking adapter 3; Alpha arrestin; controls nutrient-mediated intracellular sorting of permease Gap1p; interacts with AP-1 subunit Apl4p; phosphorylated by Npr1p and also by cyclin-CDK complex Pcl7p-Pho85p; promotes endocytosis of plasma membrane proteins; ALY2 has a paralog, ALY1, that arose from the whole genome duplication.


ensembl_gene_id: YJL085W
symbol: EXO70
gene_biotype: protein_coding
description:
  Subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis prior to SNARE-mediated fusion; PtdIns[4,5]P2-binding protein that localizes to exocytic sites in an actin-independent manner, targeting and anchoring the exocyst with Sec3p; involved in exocyst assembly; direct downstream effector of Rho3p and Cdc42p; relocalizes from bud neck to cytoplasm upon DNA replication stress.


ensembl_gene_id: YJL086C
symbol: YJL086C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YJL086C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL085W/EXO70 and YJL087C/TRL1.


ensembl_gene_id: YJL087C
symbol: TRL1
gene_biotype: protein_coding
description:
  tRNA ligase; required for tRNA splicing and for both splicing and translation of HAC1 mRNA in the UPR; has phosphodiesterase, polynucleotide kinase, and ligase activities; localized at the inner nuclear envelope and partially to polysomes.


ensembl_gene_id: YJL088W
symbol: ARG3
gene_biotype: protein_coding
description:
  Ornithine carbamoyltransferase; also known as carbamoylphosphate:L-ornithine carbamoyltransferase; catalyzes the biosynthesis of the arginine precursor citrulline.


ensembl_gene_id: YJL089W
symbol: SIP4
gene_biotype: protein_coding
description:
  Protein SIP4; C6 zinc cluster transcriptional activator; binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus.


ensembl_gene_id: YJL090C
symbol: DPB11
gene_biotype: protein_coding
description:
  DNA replication initiation protein; loads DNA pol epsilon onto pre-replication complexes at origins; checkpoint sensor recruited to stalled replication forks by the checkpoint clamp complex where it activates Mec1p; along with Rfa1p, binds to ultrafine anaphase bridges in mitotic cells and prevents accumulation of chromatin bridges by stimulating the Mec1p kinase and suppressing homologous recombination; ortholog of human TopBP1; forms nuclear foci upon DNA replication stress.


ensembl_gene_id: YJL091C
symbol: GWT1
gene_biotype: protein_coding
description:
  GPI-anchored wall transfer protein 1; Protein involved in the inositol acylation of GlcN-PI; the inositol acylation of glucosaminyl phosphatidylinositol (GlcN-PI) forms glucosaminyl(acyl)phosphatidylinositol (GlcN(acyl)PI), an intermediate in the biosynthesis of glycosylphosphatidylinositol (GPI) anchors; Belongs to the PIGW family.


ensembl_gene_id: YJL092W
symbol: SRS2
gene_biotype: protein_coding
description:
  DNA helicase and DNA-dependent ATPase; involved in DNA repair and checkpoint recovery, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; blocks trinucleotide repeat expansion; affects genome stability; disassembles Rad51p nucleoprotein filaments during meiotic recombination; stimulates activity of the Mus81p-Mms4p endonuclease, independently of Srs2p catalytic activity; functional homolog of human RTEL1.


ensembl_gene_id: YJL093C
symbol: TOK1
gene_biotype: protein_coding
description:
  Outward-rectifier potassium channel of the plasma membrane; has two pore domains in tandem, each of which forms a functional channel permeable to potassium; carboxy tail functions to prevent inner gate closures; target of K1 toxin.


ensembl_gene_id: YJL094C
symbol: KHA1
gene_biotype: protein_coding
description:
  K(+)/H(+) antiporter 1; Putative K+/H+ antiporter; has a probable role in intracellular cation homeostasis; localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies.


ensembl_gene_id: YJL095W
symbol: BCK1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase BCK1/SLK1/SSP31; MAPKKK acting in the protein kinase C signaling pathway; the kinase C signaling pathway controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p; MAPKKK is an acronym for mitogen-activated protein (MAP) kinase kinase kinase.


ensembl_gene_id: YJL097W
symbol: PHS1
gene_biotype: protein_coding
description:
  Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase PHS1; Essential 3-hydroxyacyl-CoA dehydratase of the ER membrane; involved in elongation of very long-chain fatty acids; evolutionarily conserved, similar to mammalian PTPLA and PTPLB; involved in sphingolipid biosynthesis and protein trafficking.


ensembl_gene_id: YJL098W
symbol: SAP185
gene_biotype: protein_coding
description:
  SIT4-associating protein SAP185; Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap190p; SAP185 has a paralog, SAP190, that arose from the whole genome duplication; Belongs to the SAPS family.


ensembl_gene_id: YJL099W
symbol: CHS6
gene_biotype: protein_coding
description:
  Chitin biosynthesis protein CHS6; Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; primary component of the Chs5/6 complex that binds directly to membranes; CHS6 has a paralog, BCH2, that arose from the whole genome duplication.


ensembl_gene_id: YJL100W
symbol: LSB6
gene_biotype: protein_coding
description:
  Type II phosphatidylinositol 4-kinase; binds Las17p, a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; Belongs to the PI3/PI4-kinase family.


ensembl_gene_id: YJL101C
symbol: GSH1
gene_biotype: protein_coding
description:
  Glutamate--cysteine ligase; Gamma glutamylcysteine synthetase; catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury; protein abundance increases in response to DNA replication stress; Belongs to the glutamate--cysteine ligase type 3 family.


ensembl_gene_id: YJL102W
symbol: MEF2
gene_biotype: protein_coding
description:
  Mitochondrial elongation factor involved in translational elongation; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.


ensembl_gene_id: YJL103C
symbol: GSM1
gene_biotype: protein_coding
description:
  Glucose starvation modulator protein 1; Putative zinc cluster protein of unknown function; proposed to be involved in the regulation of energy metabolism, based on patterns of expression and sequence analysis; Belongs to the ERT1/acuK family.


ensembl_gene_id: YJL104W
symbol: PAM16
gene_biotype: protein_coding
description:
  Subunit of the import motor (PAM complex); the PAM complex is a  component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); forms a 1:1 subcomplex with Pam18p and inhibits its cochaperone activity; contains a J-like domain; Belongs to the TIM16/PAM16 family.


ensembl_gene_id: YJL105W
symbol: SET4
gene_biotype: protein_coding
description:
  Protein of unknown function, contains a SET domain; SET4 has a paralog, SET3, that arose from the whole genome duplication.


ensembl_gene_id: YJL106W
symbol: IME2
gene_biotype: protein_coding
description:
  Serine/threonine protein kinase involved in activation of meiosis; associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p; human CDK2 can complement ime2 null mutant.


ensembl_gene_id: YJL107C
symbol: YJL107C
gene_biotype: protein_coding
description:
  Uncharacterized UPF0442 protein YJL107C; Putative protein of unknown function; expression is induced by activation of the HOG1 mitogen-activated signaling pathway and this induction is Hog1p/Pbs2p dependent; YJL107C and adjacent ORF, YJL108C are merged in related fungi.


ensembl_gene_id: YJL108C
symbol: PRM10
gene_biotype: protein_coding
description:
  Pheromone-regulated protein; proposed to be involved in mating; predicted to have 5 transmembrane segments; induced by treatment with 8-methoxypsoralen and UVA irradiation.


ensembl_gene_id: YJL109C
symbol: UTP10
gene_biotype: protein_coding
description:
  Nucleolar protein; component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; mutant has increased aneuploidy tolerance.


ensembl_gene_id: YJL110C
symbol: GZF3
gene_biotype: protein_coding
description:
  GATA zinc finger protein; negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding; function requires a repressive carbon source; dimerizes with Dal80p and binds to Tor1p; GZF3 has a paralog, DAL80, that arose from the whole genome duplication.


ensembl_gene_id: YJL111W
symbol: CCT7
gene_biotype: protein_coding
description:
  T-complex protein 1 subunit eta; Subunit of the cytosolic chaperonin Cct ring complex; related to Tcp1p, required for the assembly of actin and tubulins in vivo; mutant has increased aneuploidy tolerance.


ensembl_gene_id: YJL112W
symbol: MDV1
gene_biotype: protein_coding
description:
  Peripheral protein of cytosolic face of mitochondrial outer membrane; required for mitochondrial fission; interacts with Fis1p and with the self-assembled oligomeric form of the dynamin-related GTPase Dnm1p; contains WD repeats; MDV1 has a paralog, CAF4, that arose from the whole genome duplication.


ensembl_gene_id: YJL115W
symbol: ASF1
gene_biotype: protein_coding
description:
  Histone chaperone ASF1; Nucleosome assembly factor; involved in chromatin assembly, disassembly; required for recovery after DSB repair; role in H3K56 acetylation required for expression homeostasis, buffering mRNA synthesis rate against gene dosage changes in S phase; anti-silencing protein, derepresses silent loci when overexpressed; role in regulating Ty1 transposition; relocalizes to cytosol under hypoxia; growth defect of asf1 null is functionally complemented by either human ASF1A or ASF1B.


ensembl_gene_id: YJL116C
symbol: NCA3
gene_biotype: protein_coding
description:
  Protein involved in mitochondrion organization; functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; SWAT-GFP, seamless-GFP and mCherry fusion proteins localize to the vacuole; member of the SUN family; expression induced in cells treated with the mycotoxin patulin; NCA3 has a paralog, UTH1, that arose from the whole genome duplication.


ensembl_gene_id: YJL117W
symbol: PHO86
gene_biotype: protein_coding
description:
  Inorganic phosphate transporter PHO86; Endoplasmic reticulum (ER) resident protein; required for ER exit of the high-affinity phosphate transporter Pho84p, specifically required for packaging of Pho84p into COPII vesicles; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YJL118W
symbol: YJL118W
gene_biotype: protein_coding
description:
  Uncharacterized protein YJL118W; Protein of unknown function; may interact with ribosomes, based on co-purification experiments; YJL118W is a non-essential gene; deletion enhances the toxicity of heterologously expressed human alpha-synuclein.


ensembl_gene_id: YJL119C
symbol: YJL119C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YJL119C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YJL120W
symbol: YJL120W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YJL120W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL121C/RPE1; deletion confers sensitivity to GSAO.


ensembl_gene_id: YJL121C
symbol: RPE1
gene_biotype: protein_coding
description:
  D-ribulose-5-phosphate 3-epimerase; catalyzes a reaction in the non-oxidative part of the pentose-phosphate pathway; mutants are sensitive to oxidative stress.


ensembl_gene_id: YJL122W
symbol: ALB1
gene_biotype: protein_coding
description:
  Ribosome biogenesis protein ALB1; Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit; interacts directly with Arx1p; responsible for Tif6p recycling defects in absence of Rei1p.


ensembl_gene_id: YJL123C
symbol: MTC1
gene_biotype: protein_coding
description:
  Maintenance of telomere capping protein 1; Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to COPI-coated vesicles (early Golgi); mtc1 is synthetically lethal with cdc13-1.


ensembl_gene_id: YJL124C
symbol: LSM1
gene_biotype: protein_coding
description:
  Sm-like protein LSm1; Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs; also enters the nucleus and positively regulates transcription initiation; unlike most Sm-like proteins, Lsm1p requires both its SM-domain and C-terminal domain for RNA-binding; binds to mRNAs under glucose starvation, most often in the 3' UTR; forms cytoplasmic foci upon DNA replication stress.


ensembl_gene_id: YJL125C
symbol: GCD14
gene_biotype: protein_coding
description:
  tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61; Subunit of tRNA (1-methyladenosine) methyltransferase; required, along with Gcd10p, for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression; Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.


ensembl_gene_id: YJL126W
symbol: NIT2
gene_biotype: protein_coding
description:
  Deaminated glutathione amidase; Nit protein; one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member; Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.


ensembl_gene_id: YJL127C
symbol: SPT10
gene_biotype: protein_coding
description:
  Protein SPT10; Histone H3 acetylase with a role in transcriptional regulation; sequence-specific activator of histone genes, binds specifically and cooperatively to pairs of UAS elements in core histone promoters, functions at or near TATA box; involved in S phase-specific acetylation of H3K56 at histone promoters, which is required for recruitment of SWI/SNF nucleosome remodeling complex and subsequent transcription.


ensembl_gene_id: YJL127C-B
symbol: YJL127C-B
gene_biotype: protein_coding
description:
  UPF0618 protein YJL127C-B; Putative protein of unknown function; identified based on homology to the filamentous fungus, <i>Ashbya gossypii</i>; SWAT-GFP and seamless-GFP fusion proteins localize to the mitochondria.


ensembl_gene_id: YJL127W-A
symbol: YJL127W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YJL127W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YJL128C
symbol: PBS2
gene_biotype: protein_coding
description:
  MAP kinase kinase of the HOG signaling pathway; activated under severe osmotic stress; mitophagy-specific regulator; plays a role in regulating Ty1 transposition; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.


ensembl_gene_id: YJL129C
symbol: TRK1
gene_biotype: protein_coding
description:
  Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation; TRK1 has a paralog, TRK2, that arose from the whole genome duplication; Belongs to the TrkH potassium transport family.


ensembl_gene_id: YJL130C
symbol: URA2
gene_biotype: protein_coding
description:
  Glutamine-dependent carbamoyl-phosphate synthase; Bifunctional carbamoylphosphate synthetase/aspartate transcarbamylase; catalyzes the first two enzymatic steps in the de novo biosynthesis of pyrimidines; both activities are subject to feedback inhibition by UTP; In the central section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily.


ensembl_gene_id: YJL131C
symbol: AIM23
gene_biotype: protein_coding
description:
  Altered inheritance of mitochondria protein 23, mitochondrial; Mitochondrial translation initiation factor 3 (IF3, mIF3); evolutionarily conserved; binds to E. coli ribosomes in vitro; null mutant displays severe respiratory growth defect and elevated frequency of mitochondrial genome loss.


ensembl_gene_id: YJL132W
symbol: YJL132W
gene_biotype: protein_coding
description:
  Uncharacterized protein YJL132W; Putative protein of unknown function; localizes to the membrane fraction; possible Zap1p-regulated target gene induced by zinc deficiency; YJL132W is a non-essential gene.


ensembl_gene_id: YJL133C-A
symbol: YJL133C-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YJL133C-A; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies.


ensembl_gene_id: YJL133W
symbol: MRS3
gene_biotype: protein_coding
description:
  Mitochondrial RNA-splicing protein MRS3; Iron transporter, mediates Fe2+ transport across inner mito membrane; mitochondrial carrier family member; active under low-iron conditions; may transport other cations; MRS3 has a paralog, MRS4, that arose from the whole genome duplication.


ensembl_gene_id: YJL134W
symbol: LCB3
gene_biotype: protein_coding
description:
  Long-chain base-1-phosphate phosphatase; specific for dihydrosphingosine-1-phosphate, regulates ceramide and long-chain base phosphates levels, involved in incorporation of exogenous long chain bases in sphingolipids; LCB3 has a paralog, YSR3, that arose from the whole genome duplication.


ensembl_gene_id: YJL135W
symbol: YJL135W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YJL135W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL134W/LCB3.


ensembl_gene_id: YJL136C
symbol: RPS21B
gene_biotype: protein_coding
description:
  Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication.


ensembl_gene_id: YJL137C
symbol: GLG2
gene_biotype: protein_coding
description:
  Glycogenin-2; Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin; GLG2 has a paralog, GLG1, that arose from the whole genome duplication.


ensembl_gene_id: YJL138C
symbol: TIF2
gene_biotype: protein_coding
description:
  Translation initiation factor eIF4A; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G; protein abundance increases in response to DNA replication stress; TIF2 has a paralog, TIF1, that arose from the whole genome duplication.


ensembl_gene_id: YJL139C
symbol: YUR1
gene_biotype: protein_coding
description:
  Probable mannosyltransferase YUR1; Mannosyltransferase involved in protein N-glycosylation; member of the KTR1 family; located in the Golgi apparatus; YUR1 has a paralog, KTR2, that arose from the whole genome duplication; Belongs to the glycosyltransferase 15 family.


ensembl_gene_id: YJL140W
symbol: RPB4
gene_biotype: protein_coding
description:
  RNA polymerase II subunit B32; forms dissociable heterodimer with Rpb7p; Rpb4/7 dissociates from RNAPII as Ser2 CTD phosphorylation increases; Rpb4/7 regulates cellular lifespan via mRNA decay process; involved in recruitment of 3'-end processing factors to transcribing RNAPII complex, export of mRNA to cytoplasm under stress conditions; also involved in translation initiation.


ensembl_gene_id: YJL141C
symbol: YAK1
gene_biotype: protein_coding
description:
  Dual specificity protein kinase YAK1; Serine-threonine protein kinase; component of a glucose-sensing system that inhibits growth in response to glucose availability; upon nutrient deprivation Yak1p phosphorylates Pop2p to regulate mRNA deadenylation, the co-repressor Crf1p to inhibit transcription of ribosomal genes, and the stress-responsive transcription factors Hsf1p and Msn2p; nuclear localization negatively regulated by the Ras/PKA signaling pathway in the presence of glucose.


ensembl_gene_id: YJL142C
symbol: IRC9
gene_biotype: protein_coding
description:
  Putative uncharacterized protein IRC9; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified gene YJL141C; null mutant displays increased levels of spontaneous Rad52p foci.


ensembl_gene_id: YJL143W
symbol: TIM17
gene_biotype: protein_coding
description:
  Mitochondrial import inner membrane translocase subunit TIM17; Essential component of the TIM23 complex; with Tim23p, contributes to the architecture and function of the import channel; may link the import motor to the core Translocase of the Inner Mitochondrial membrane (TIM23 complex); Belongs to the Tim17/Tim22/Tim23 family.


ensembl_gene_id: YJL144W
symbol: YJL144W
gene_biotype: protein_coding
description:
  Uncharacterized protein YJL144W; Cytoplasmic hydrophilin essential in desiccation-rehydration process; expression induced by osmotic stress, starvation and during stationary phase; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YJL145W
symbol: SFH5
gene_biotype: protein_coding
description:
  Non-classical phosphatidylinositol transfer protein (PITP); exhibits PI- but not PC-transfer activity; localizes to the peripheral endoplasmic reticulum, cytosol and microsomes; similar to Sec14p; partially relocalizes to the plasma membrane upon DNA replication stress.


ensembl_gene_id: YJL146W
symbol: IDS2
gene_biotype: protein_coding
description:
  Protein involved in modulation of Ime2p activity during meiosis; appears to act indirectly to promote Ime2p-mediated late meiotic functions; found in growing cells and degraded during sporulation.


ensembl_gene_id: YJL147C
symbol: MRX5
gene_biotype: protein_coding
description:
  MIOREX complex component 5; Protein that associates with mitochondrial ribosome; homozygous diploid deletion strain has a sporulation defect characterized by elevated dityrosine in the soluble fraction; expression induced by calcium shortage; YJL147W is a non-essential gene.


ensembl_gene_id: YJL148W
symbol: RPA34
gene_biotype: protein_coding
description:
  RNA polymerase I subunit A34.5; essential for nucleolar assembly and for high polymerase loading rate; nucleolar localization depends on Rpa49p; Belongs to the eukaryotic RPA34 RNA polymerase subunit family.


ensembl_gene_id: YJL149W
symbol: DAS1
gene_biotype: protein_coding
description:
  F-box protein DAS1; Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C.


ensembl_gene_id: YJL150W
symbol: YJL150W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YJL150W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YJL151C
symbol: SNA3
gene_biotype: protein_coding
description:
  Protein involved in efficient MVB sorting of proteins to the vacuole; may function as an RSP5 adapter protein for MVB cargos; integral membrane protein localized to vacuolar intralumenal vesicles.


ensembl_gene_id: YJL152W
symbol: YJL152W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YJL152W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YJL153C
symbol: INO1
gene_biotype: protein_coding
description:
  Inositol-3-phosphate synthase; involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element; Belongs to the myo-inositol 1-phosphate synthase family.


ensembl_gene_id: YJL154C
symbol: VPS35
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 35; Endosomal subunit of membrane-associated retromer complex; required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p; overexpression of wild-type human VPS35 or Parkinson's-associated vps35-D686N or vps35-P299S variants complements Ni2+ resistance and Cd2+ sensitivity of yeast vps35 null mutant.


ensembl_gene_id: YJL155C
symbol: FBP26
gene_biotype: protein_coding
description:
  Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YJL156C
symbol: SSY5
gene_biotype: protein_coding
description:
  SPS-sensor serine protease component SSY5; Serine protease of SPS plasma membrane amino acid sensor system; contains an inhibitory domain that dissociates in response to extracellular amino acids, freeing a catalytic domain to activate transcription factor Stp1p; other members are Ssy1p and Ptr3p.


ensembl_gene_id: YJL156W-A
symbol: YJL156W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YJL156W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YJL157C
symbol: FAR1
gene_biotype: protein_coding
description:
  CDK inhibitor and nuclear anchor; during the cell cycle Far1p sequesters the GEF Cdc24p in the nucleus; phosphorylation by Cdc28p-Cln results in SCFCdc4 complex-mediated ubiquitin-dependent degradation, releasing Cdc24p for export and activation of GTPase Cdc42p; in response to pheromone, phosphorylation of Far1p by MAPK Fus3p results in association with, and inhibition of Cdc28p-Cln, as well as Msn5p mediated nuclear export of Far1p-Cdc24p, targeting Cdc24p to polarity sites.


ensembl_gene_id: YJL158C
symbol: CIS3
gene_biotype: protein_coding
description:
  Cell wall mannoprotein CIS3; Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family.


ensembl_gene_id: YJL159W
symbol: HSP150
gene_biotype: protein_coding
description:
  Cell wall mannoprotein HSP150; O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication.


ensembl_gene_id: YJL160C
symbol: PIR5
gene_biotype: protein_coding
description:
  Cell wall protein PIR5; Putative protein of unknown function; member of the PIR (Proteins with Internal Repeats) family of cell wall proteins; SWAT-GFP fusion protein localizes to the endoplasmic reticulum and vacuole, and mCherry fusion localizes to the vacuole; non-essential gene that is required for sporulation; mRNA is weakly cell cycle regulated, peaking in mitosis; YJL160C has a paralog, PIR1, that arose from the whole genome duplication.


ensembl_gene_id: YJL161W
symbol: FMP33
gene_biotype: protein_coding
description:
  Mitochondrial membrane protein FMP33; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies.


ensembl_gene_id: YJL162C
symbol: JJJ2
gene_biotype: protein_coding
description:
  J protein JJJ2; Protein of unknown function; contains a J-domain, which is a region with homology to the E. coli DnaJ protein.


ensembl_gene_id: YJL164C
symbol: TPK1
gene_biotype: protein_coding
description:
  cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; phosphorylates and inhibits Whi3p to promote G1/S phase passage; partially redundant with Tpk2p and Tpk3p; phosphorylates pre-Tom40p, which impairs its import into mitochondria under non-respiratory conditions; TPK1 has a paralog, TPK3, that arose from the whole genome duplication.


ensembl_gene_id: YJL165C
symbol: HAL5
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase HAL5; Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters; HAL5 has a paralog, KKQ8, that arose from the whole genome duplication.


ensembl_gene_id: YJL166W
symbol: QCR8
gene_biotype: protein_coding
description:
  Subunit 8 of ubiquinol cytochrome-c reductase (Complex III); Complex III is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p; Belongs to the UQCRQ/QCR8 family.


ensembl_gene_id: YJL167W
symbol: ERG20
gene_biotype: protein_coding
description:
  Farnesyl pyrophosphate synthetase; has both dimethylallyltranstransferase and geranyltranstransferase activities; catalyzes the formation of C15 farnesyl pyrophosphate units for isoprenoid and sterol biosynthesis.


ensembl_gene_id: YJL168C
symbol: SET2
gene_biotype: protein_coding
description:
  Histone-lysine N-methyltransferase, H3 lysine-36 specific; Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36 (H3K36), which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain(CTD) of Rpo21p; H3K36me3 (trimethylation) requires Spt6p, proline 38 on H3, CTD of Rpo21p, Ctk1p, and C-terminal SRI domain of Ste2p; relocalizes to the cytosol in response to hypoxia.


ensembl_gene_id: YJL169W
symbol: YJL169W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YJL169W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL168C/SET2.


ensembl_gene_id: YJL170C
symbol: ASG7
gene_biotype: protein_coding
description:
  Protein that regulates signaling from G protein beta subunit Ste4p; contributes to relocalization of Ste4p within the cell; specific to a-cells and induced by alpha-factor.


ensembl_gene_id: YJL171C
symbol: TOH1
gene_biotype: protein_coding
description:
  GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress; Belongs to the PGA52 family.


ensembl_gene_id: YJL173C
symbol: RFA3
gene_biotype: protein_coding
description:
  Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein complex involved in DNA replication, repair, recombination; RPA protects against inappropriate telomere recombination, and upon telomere uncapping, prevents cell proliferation by a checkpoint-independent pathway; with Sgs1p-Top2p-Rmi1p, stimulates DNA catenation/decatenation activity of Top3p; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YJL174W
symbol: KRE9
gene_biotype: protein_coding
description:
  Glycoprotein involved in cell wall beta-glucan assembly; null mutation leads to severe growth defects, aberrant multibudded morphology, and mating defects.


ensembl_gene_id: YJL175W
symbol: YJL175W
gene_biotype: protein_coding
description:
  Putative uncharacterized membrane protein YJL175W; Dubious open reading frame unlikely to encode a functional protein; deletion confers resistance to cisplatin, hypersensitivity to 5-fluorouracil, and growth defect at high pH with high calcium; overlaps gene for SWI3 transcription factor.


ensembl_gene_id: YJL176C
symbol: SWI3
gene_biotype: protein_coding
description:
  Subunit of the SWI/SNF chromatin remodeling complex; SWI/SNF regulates transcription by remodeling chromosomes; contains SANT domain that is required for SWI/SNF assembly; is essential for displacement of histone H2A-H2B dimers during ATP-dependent remodeling; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; relocates to the cytosol under hypoxic conditions.


ensembl_gene_id: YJL177W
symbol: RPL17B
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L17B; required for processing of 27SB pre-rRNA and formation of stable 66S assembly intermediates; homologous to mammalian ribosomal protein L17 and bacterial L22; RPL17B has a paralog, RPL17A, that arose from the whole genome duplication.


ensembl_gene_id: YJL178C
symbol: ATG27
gene_biotype: protein_coding
description:
  Autophagy-related protein 27; Type I membrane protein involved in autophagy and the Cvt pathway; may be involved in membrane delivery to the phagophore assembly site; Belongs to the ATG27 family.


ensembl_gene_id: YJL179W
symbol: PFD1
gene_biotype: protein_coding
description:
  Subunit of heterohexameric prefoldin; prefoldin binds cytosolic chaperonin and transfers target proteins to it; involved in the biogenesis of actin and of alpha- and gamma-tubulin; prefoldin complex also localizes to chromatin of actively transcribed genes in the nucleus and facilitates transcriptional elongation.


ensembl_gene_id: YJL180C
symbol: ATP12
gene_biotype: protein_coding
description:
  Protein ATP12, mitochondrial; Assembly factor for F1 sector of mitochondrial F1F0 ATP synthase; conserved protein; required for assembly of alpha and beta subunits into F1 sector of mitochondrial F1F0 ATP synthase; human homolog ATPAF2 can complement yeast atp12 mutant; mutation of human homolog reduces active ATP synthase levels and is associated with the disorder ATPAF2 deficiency.


ensembl_gene_id: YJL181W
symbol: RBH1
gene_biotype: protein_coding
description:
  UPF0508 protein YJL181W; Putative protein of unknown function; expression is cell-cycle regulated as shown by microarray analysis; potential regulatory target of Mbp1p, which binds to the YJL181W promoter region; contains a PH-like domain; RBH1 has a paralog, RBH2, that arose from the whole genome duplication; Belongs to the UPF0508 family.


ensembl_gene_id: YJL182C
symbol: YJL182C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YJL182C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YJL181W.


ensembl_gene_id: YJL183W
symbol: MNN11
gene_biotype: protein_coding
description:
  Probable alpha-1,6-mannosyltransferase MNN11; Subunit of a Golgi mannosyltransferase complex; this complex also contains Anp1p, Mnn9p, Mnn10p, and Hoc1p, and mediates elongation of the polysaccharide mannan backbone; has homology to Mnn10p; Belongs to the glycosyltransferase 34 family.


ensembl_gene_id: YJL184W
symbol: GON7
gene_biotype: protein_coding
description:
  Component of the EKC/KEOPS protein complex; EKC/KEOPS complex is required for t6A tRNA modification and telomeric TG1-3 recombination; may have role in transcription; implicated in osmotic stress response; other complex members are Kae1p, Cgi121p, Pcc1p, and Bud32p; Belongs to the GON7 family.


ensembl_gene_id: YJL185C
symbol: ATG36
gene_biotype: protein_coding
description:
  Autophagy-related protein 36; Pex3p interacting protein, required for pexophagy; interacts with Atg8p and Atg11p; mRNA is weakly cell cycle regulated, peaking in G2 phase; YJL185C is a non-essential gene.


ensembl_gene_id: YJL186W
symbol: MNN5
gene_biotype: protein_coding
description:
  Alpha-1,2-mannosyltransferase; responsible for addition of the second alpha-1,2-linked mannose of the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment; Belongs to the MNN1/MNT family.


ensembl_gene_id: YJL187C
symbol: SWE1
gene_biotype: protein_coding
description:
  Mitosis inhibitor protein kinase SWE1; Protein kinase that regulates the G2/M transition; negative regulator of the Cdc28p kinase; morphogenesis checkpoint kinase; positive regulator of sphingolipid biosynthesis via Orm2p; phosphorylates a tyrosine residue in the N-terminus of Hsp90 in a cell-cycle associated manner, thus modulating the ability of Hsp90 to chaperone a selected clientele; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog of S. pombe Wee1p; potential Cdc28p substrate.


ensembl_gene_id: YJL188C
symbol: BUD19
gene_biotype: protein_coding
description:
  Putative uncharacterized protein BUD19; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay.


ensembl_gene_id: YJL189W
symbol: RPL39
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L39; required for ribosome biogenesis; loss of both Rpl31p and Rpl39p confers lethality; also exhibits genetic interactions with SIS1 and PAB1; homologous to mammalian ribosomal protein L39, no bacterial homolog.


ensembl_gene_id: YJL190C
symbol: RPS22A
gene_biotype: protein_coding
description:
  Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22A has a paralog, RPS22B, that arose from the whole genome duplication.


ensembl_gene_id: YJL191W
symbol: RPS14B
gene_biotype: protein_coding
description:
  Protein component of the small (40S) ribosomal subunit; required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; homologous to mammalian ribosomal protein S14 and bacterial S11; RPS14B has a paralog, RPS14A, that arose from the whole genome duplication.


ensembl_gene_id: YJL192C
symbol: SOP4
gene_biotype: protein_coding
description:
  ER-membrane protein; subunit of evolutionarily conserved EMC (Endoplasmic Reticulum Membrane Complex) implicated in ERAD (ER-associated degradation) and proper assembly of multi-pass transmembrane (TM) proteins; EMC acts in yeast as an ER-mitochondria tether that interacts with outer membrane protein Tom5 of TOM (Translocase of the Mitochondrial Outer Membrane) complex; suppressor of pma1-7, deletion of SOP4 slows down export of wild-type Pma1p and Pma1-7 from the ER.


ensembl_gene_id: YJL193W
symbol: YJL193W
gene_biotype: protein_coding
description:
  Uncharacterized transporter YJL193W; Putative protein of unknown function; predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect.


ensembl_gene_id: YJL194W
symbol: CDC6
gene_biotype: protein_coding
description:
  Cell division control protein 6; Essential ATP-binding protein required for DNA replication; component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; homologous to S. pombe Cdc18p; relocalizes from nucleus to cytoplasm upon DNA replication stress; degraded in response to plasma membrane stress.


ensembl_gene_id: YJL195C
symbol: YJL195C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YJL195C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL194W/CDC6.


ensembl_gene_id: YJL196C
symbol: ELO1
gene_biotype: protein_coding
description:
  Elongation of fatty acids protein 1; Elongase I, medium-chain acyl elongase; catalyzes carboxy-terminal elongation of unsaturated C12-C16 fatty acyl-CoAs to C16-C18 fatty acids; ELO1 has a paralog, ELO2, that arose from the whole genome duplication.


ensembl_gene_id: YJL197C-A
symbol: YJL197C-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YJL197C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL197C/UBP12.


ensembl_gene_id: YJL197W
symbol: UBP12
gene_biotype: protein_coding
description:
  Ubiquitin carboxyl-terminal hydrolase 12; Ubiquitin-specific protease; cleaves ubiquitin from ubiquitinated proteins; present in the nucleus and cytoplasm; Belongs to the peptidase C19 family.


ensembl_gene_id: YJL198W
symbol: PHO90
gene_biotype: protein_coding
description:
  Low-affinity phosphate transporter; acts upstream of Pho81p in regulation of the PHO pathway; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth; PHO90 has a paralog, PHO87, that arose from the whole genome duplication; Belongs to the CitM (TC 2.A.11) transporter family.


ensembl_gene_id: YJL199C
symbol: MBB1
gene_biotype: protein_coding
description:
  Uncharacterized protein MBB1; Putative protein of unknown function; conserved among S. cerevisiae strains, not conserved in closely related Saccharomyces species; protein detected in large-scale protein-protein interaction studies; YJL199C is not an essential gene.


ensembl_gene_id: YJL200C
symbol: ACO2
gene_biotype: protein_coding
description:
  Homocitrate dehydratase, mitochondrial; Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol.


ensembl_gene_id: YJL201W
symbol: ECM25
gene_biotype: protein_coding
description:
  Non-essential protein of unknown function; promoter contains a consensus binding sequence for factor Abf1p.


ensembl_gene_id: YJL202C
symbol: YJL202C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YJL202C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 3' end of essential PRP21 gene encoding a subunit of the SF3a splicing factor complex.


ensembl_gene_id: YJL203W
symbol: PRP21
gene_biotype: protein_coding
description:
  Pre-mRNA-splicing factor PRP21; Subunit of the SF3a splicing factor complex; required for spliceosome assembly.


ensembl_gene_id: YJL204C
symbol: RCY1
gene_biotype: protein_coding
description:
  Recyclin-1; F-box protein involved in recycling endocytosed proteins; involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth; direct interaction with C-terminal cytoplasmic region of Drs2p plays an important role for Drs2p function in endocytic recycling pathway.


ensembl_gene_id: YJL205C
symbol: NCE101
gene_biotype: protein_coding
description:
  Non-classical export protein 1; Protein of unknown function; involved in secretion of proteins that lack classical secretory signal sequences; SWAT-GFP and mCherry fusion proteins localize to the cytosol; Belongs to the NCE101 family.


ensembl_gene_id: YJL206C
symbol: YJL206C
gene_biotype: protein_coding
description:
  Putative protein of unknown function; similar to transcriptional regulators from the Zn[2]-Cys[6] binuclear cluster protein family; mRNA is weakly cell cycle regulated, peaking in S phase; induced rapidly upon MMS treatment; Belongs to the ASG1 family.


ensembl_gene_id: YJL207C
symbol: LAA1
gene_biotype: protein_coding
description:
  AP-1 accessory protein; colocalizes with clathrin to the late-Golgi apparatus; involved in TGN-endosome transport; physically interacts with AP-1; similar to the mammalian p200; may interact with ribosomes; YJL207C is a non-essential gene.


ensembl_gene_id: YJL208C
symbol: NUC1
gene_biotype: protein_coding
description:
  Major mitochondrial nuclease; has RNAse and DNA endo- and exonucleolytic activities; roles in mitochondrial recombination, apoptosis and maintenance of polyploidy; involved in fragmentation of genomic DNA during PND (programmed nuclear destruction); encodes ortholog of mammalian endoG; Belongs to the DNA/RNA non-specific endonuclease family.


ensembl_gene_id: YJL209W
symbol: CBP1
gene_biotype: protein_coding
description:
  Cytochrome B pre-mRNA-processing protein 1; Mitochondrial protein, regulator of COB mRNA stability and translation; interacts with the 5'-untranslated region of the COB mRNA; found in a complex at the inner membrane along with Pet309p; localizes to mitochondrial foci upon DNA replication stress.


ensembl_gene_id: YJL210W
symbol: PEX2
gene_biotype: protein_coding
description:
  Peroxisomal biogenesis factor 2; RING-finger peroxin and E3 ubiquitin ligase; peroxisomal membrane protein with a C-terminal zinc-binding RING domain, forms translocation subcomplex with Pex10p and Pex12p which functions in peroxisomal matrix protein import.


ensembl_gene_id: YJL211C
symbol: YJL211C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YJL211C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL210W/PEX2.


ensembl_gene_id: YJL212C
symbol: OPT1
gene_biotype: protein_coding
description:
  Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family.


ensembl_gene_id: YJL213W
symbol: YJL213W
gene_biotype: protein_coding
description:
  Uncharacterized protein YJL213W; Protein of unknown function that may interact with ribosomes; periodically expressed during the yeast metabolic cycle; phosphorylated in vitro by the mitotic exit network (MEN) kinase complex, Dbf2p/Mob1p; Belongs to the metallo-dependent hydrolases superfamily.


ensembl_gene_id: YJL214W
symbol: HXT8
gene_biotype: protein_coding
description:
  Hexose transporter HXT8; Protein of unknown function with similarity to hexose transporters; expression is induced by low levels of glucose and repressed by high levels of glucose.


ensembl_gene_id: YJL215C
symbol: YJL215C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YJL215C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YJL216C
symbol: IMA5
gene_biotype: protein_coding
description:
  Oligo-1,6-glucosidase IMA5; Alpha-glucosidase; specificity for isomaltose, maltose, and palatinose, but not alpha-methylglucoside; most distant member of the IMA isomaltase family, but with similar catalytic properties as Ima1p and Ima2p; not required for isomaltose utilization, but Ima5p overexpression allows the ima1 null mutant to grow on isomaltose; can cleave alpha-1,3 linkage of nigerose and turanose and alpha-1,5 linkage of leucrose and is very sensitive to temperature in vitro.


ensembl_gene_id: YJL217W
symbol: REE1
gene_biotype: protein_coding
description:
  Cytoplasmic protein involved in the regulation of enolase (ENO1); mRNA expression is induced by calcium shortage, copper deficiency (via Mac1p) and the presence of galactose (via Gal4p); mRNA expression is also regulated by the cell cycle.


ensembl_gene_id: YJL218W
symbol: YJL218W
gene_biotype: protein_coding
description:
  Putative acetyltransferase; similar to bacterial galactoside O-acetyltransferases; induced by oleate in an OAF1/PIP2-dependent manner; promoter contains an oleate response element consensus sequence; non-essential gene; Belongs to the transferase hexapeptide repeat family.


ensembl_gene_id: YJL219W
symbol: HXT9
gene_biotype: protein_coding
description:
  Putative hexose transporter that is nearly identical to Hxt11p; has similarity to major facilitator superfamily (MFS) transporters, expression of HXT9 is regulated by transcription factors Pdr1p and Pdr3p; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.


ensembl_gene_id: YJL220W
symbol: YJL220W
gene_biotype: protein_coding
description:
  Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL221C/FSP2.


ensembl_gene_id: YJL221C
symbol: IMA4
gene_biotype: protein_coding
description:
  Alpha-glucosidase; weak, but broad substrate specificity for alpha-1,4- and alpha-1,6-glucosides; member of IMA isomaltase family; not required for isomaltose utilization, but Ima4p overexpression allows the ima1 null mutant to grow on isomaltose; identical to IMA3.


ensembl_gene_id: YJL222W
symbol: VTH2
gene_biotype: protein_coding
description:
  VPS10 homolog 2; Putative membrane glycoprotein; has strong similarity to Vth1p and Pep1p/Vps10p; may be involved in vacuolar protein sorting.


ensembl_gene_id: YJL222W-A
symbol: YJL222W-A
gene_biotype: protein_coding
description:
  Putative UPF0377 protein YIL174W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; Belongs to the UPF0377 family.


ensembl_gene_id: YJL222W-B
symbol: YJL222W-B
gene_biotype: protein_coding
description:
  Putative UPF0377 protein YIL175W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; Belongs to the UPF0377 family.


