# geneInfo

ensembl_gene_id: YDR097C
symbol: MSH6
gene_biotype: protein_coding
description:
  Protein required for mismatch repair in mitosis and meiosis; forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; also involved in interstrand cross-link repair; potentially phosphorylated by Cdc28p.


ensembl_gene_id: YDR098C
symbol: GRX3
gene_biotype: protein_coding
description:
  Monothiol glutaredoxin-3; Glutathione-dependent oxidoreductase; hydroperoxide and superoxide-radical responsive; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage; with Grx4p, binds to Aft1p in iron-replete conditions, promoting its dissociation from promoters; evidence exists indicating that the translation start site is not Met1 as currently annotated, but rather Met36; GRX3 has a paralog, GRX4, that arose from the whole genome duplication.


ensembl_gene_id: YDR099W
symbol: BMH2
gene_biotype: protein_coding
description:
  14-3-3 protein, minor isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; abundance relative to Bmh1p increases during sporulation.


ensembl_gene_id: YDR101C
symbol: ARX1
gene_biotype: protein_coding
description:
  Probable metalloprotease ARX1; Nuclear export factor for the ribosomal pre-60S subunit; shuttling factor which directly binds FG rich nucleoporins and facilities translocation through the nuclear pore complex; interacts directly with Alb1p; responsible for Tif6p recycling defects in the absence of Rei1; associated with the ribosomal export complex.


ensembl_gene_id: YDR102C
symbol: YDR102C
gene_biotype: protein_coding
description:
  Uncharacterized protein YDR102C; Putative protein of unknown function; conserved among S. cerevisiae strains; YDR102C is not an essential gene; homozygous diploid deletion strain exhibits high budding index.


ensembl_gene_id: YDR103W
symbol: STE5
gene_biotype: protein_coding
description:
  Protein STE5; Pheromone-responsive MAPK scaffold protein; couples activation of the G-protein-coupled pheromone receptor to MAPK activation; intramolecular interaction of PH and VWA domains blocks activation of assembled signaling cascade components (Ste11p, Ste7p and Fus3p) under basal conditions; Gbeta-gamma (Ste4p-Ste18p)-dependent docking at the plasma membrane and binding of PI(4,5)P2 by the PH domain relieves autoinhibition, resulting in pheromone-dependent pathway activation.


ensembl_gene_id: YDR104C
symbol: SPO71
gene_biotype: protein_coding
description:
  Sporulation-specific protein 71; Meiosis-specific protein required for prospore membrane morphogenesis; localizes to the prospore membrane (PSM) during sporulation; required for PSM elongation and closure; genetically antagonistic to SPO1; recruits Vps13p to the PSM during sporulation; interacts and functions cooperatively with Spo73p; mutants have defects in the PSM, aberrant spore wall formation and reduced PtdIns-phosphate pools in the PSM; contains three PH-like domains.


ensembl_gene_id: YDR105C
symbol: TMS1
gene_biotype: protein_coding
description:
  Vacuolar membrane protein of unknown function; is conserved in mammals; predicted to contain eleven transmembrane helices; interacts with Pdr5p, a protein involved in multidrug resistance.


ensembl_gene_id: YDR106W
symbol: ARP10
gene_biotype: protein_coding
description:
  Actin-like protein ARP10; Component of the dynactin complex; localized to the pointed end of the Arp1p filament; may regulate membrane association of the complex; Belongs to the actin family. ARP10 subfamily.


ensembl_gene_id: YDR107C
symbol: TMN2
gene_biotype: protein_coding
description:
  Transmembrane 9 superfamily member 2; Protein with a role in cellular adhesion and filamentous growth; similar to Tmn3p; member of the evolutionarily conserved Transmembrane Nine family of proteins with nine membrane-spanning segments; TMN2 has a paralog, EMP70, that arose from the whole genome duplication; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.


ensembl_gene_id: YDR108W
symbol: TRS85
gene_biotype: protein_coding
description:
  Trafficking protein particle complex III-specific subunit 85; Component of transport protein particle (TRAPP) complex III; TRAPPIII is a multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p, regulating endosome-Golgi traffic and required for membrane expansion during autophagy and the CVT pathway; directs Ypt1p to the PAS; late post-replication meiotic role.


ensembl_gene_id: YDR110W
symbol: FOB1
gene_biotype: protein_coding
description:
  Nucleolar protein that binds the rDNA replication fork barrier site; required for replication fork blocking, recombinational hotspot activity, condensin recruitment to replication fork barrier (RFB), and rDNA repeat segregation; related to retroviral integrases.


ensembl_gene_id: YDR111C
symbol: ALT2
gene_biotype: protein_coding
description:
  Probable alanine aminotransferase; Catalytically inactive alanine transaminase; expression is repressed in the presence of alanine and repression is mediated by Nrg1p; ALT2 has a paralog, ALT1, that arose from the whole genome duplication; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.


ensembl_gene_id: YDR112W
symbol: IRC2
gene_biotype: protein_coding
description:
  Putative uncharacterized membrane protein IRC2; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps ALT2/YDR111C; null mutant displays increased levels of spontaneous Rad52p foci.


ensembl_gene_id: YDR113C
symbol: PDS1
gene_biotype: protein_coding
description:
  Securin; inhibits anaphase by binding separin Esp1p; blocks cyclin destruction and mitotic exit, essential for meiotic progression and mitotic cell cycle arrest; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation.


ensembl_gene_id: YDR114C
symbol: YDR114C
gene_biotype: protein_coding
description:
  Uncharacterized protein YDR114C; Putative protein of unknown function; deletion mutant exhibits poor growth at elevated pH and calcium.


ensembl_gene_id: YDR115W
symbol: MRX14
gene_biotype: protein_coding
description:
  Putative mitochondrial ribosomal protein of the large subunit; similar to E. coli L34 ribosomal protein; required for respiratory growth, as are most mitochondrial ribosomal proteins; protein increases in abundance and relocalizes to the plasma membrane upon DNA replication stress.


ensembl_gene_id: YDR117C
symbol: TMA64
gene_biotype: protein_coding
description:
  Translation machinery-associated protein 64; Protein of unknown function that associates with ribosomes; has a putative RNA binding domain; in mammals the corresponding protein, eIF2D, has been shown to possess translation initiation factor activity.


ensembl_gene_id: YDR118W
symbol: APC4
gene_biotype: protein_coding
description:
  Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; relative distribution to the nucleus increases upon DNA replication stress.


ensembl_gene_id: YDR118W-A
symbol: YDR118W-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YDR118W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified using a combination of expression profiling and mass spectrometry.


ensembl_gene_id: YDR119W
symbol: VBA4
gene_biotype: protein_coding
description:
  Protein of unknown function; proposed role as a basic amino acid permease based on phylogeny; GFP-fusion protein localizes to vacuolar membrane; physical interaction with Atg27p suggests a possible role in autophagy; non-essential gene; Belongs to the major facilitator superfamily.


ensembl_gene_id: YDR119W-A
symbol: COX26
gene_biotype: protein_coding
description:
  Cytochrome c oxidase subunit 26, mitochondrial; Stabilizes or regulates formation of respiratory chain supercomplexes composed of Complex III (ubiquinol-cytochrome c reductase) and Complex IV (cytochrome c oxidase).


ensembl_gene_id: YDR120C
symbol: TRM1
gene_biotype: protein_coding
description:
  tRNA (guanine(26)-N(2))-dimethyltransferase, mitochondrial; tRNA methyltransferase; two forms of protein are made by alternative translation starts; localizes to both nucleus and mitochondrion to produce modified base N2,N2-dimethylguanosine in tRNAs in both compartments; nuclear Trm1p is evenly distributed around inner nuclear membrane in WT, but mislocalizes as puncta near ER-nucleus junctions in spindle pole body (SPB) mutants; both Trm1p inner nuclear membrane targeting and maintenance depend upon SPB.


ensembl_gene_id: YDR121W
symbol: DPB4
gene_biotype: protein_coding
description:
  Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex; involved in both chromosomal DNA replication and inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; interacts with extranucleosomal DNA and acts as anchor point for ISW2 complex that retains its position on DNA during nucleosome mobilization.


ensembl_gene_id: YDR122W
symbol: KIN1
gene_biotype: protein_coding
description:
  Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; KIN1 has a paralog, KIN2, that arose from the whole genome duplication; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.


ensembl_gene_id: YDR123C
symbol: INO2
gene_biotype: protein_coding
description:
  Protein INO2; Transcription factor; component of the heteromeric Ino2p/Ino4p basic helix-loop-helix transcription activator that binds inositol/choline-responsive elements (ICREs), required for derepression of phospholipid biosynthetic genes in response to inositol depletion; involved in diauxic shift.


ensembl_gene_id: YDR124W
symbol: YDR124W
gene_biotype: protein_coding
description:
  Uncharacterized protein YDR124W; Putative protein of unknown function; non-essential gene; expression is strongly induced by alpha factor.


ensembl_gene_id: YDR125C
symbol: ECM18
gene_biotype: protein_coding
description:
  Protein of unknown function; ECM18 has a paralog, ICT1, that arose from the whole genome duplication; Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.


ensembl_gene_id: YDR126W
symbol: SWF1
gene_biotype: protein_coding
description:
  Palmitoyltransferase that acts on transmembrane proteins; including the SNAREs Snc1p, Syn8p, Tlg1p and likely all SNAREs; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; may have a role in vacuole fusion.


ensembl_gene_id: YDR127W
symbol: ARO1
gene_biotype: protein_coding
description:
  3-phosphoshikimate 1-carboxyvinyltransferase; Pentafunctional arom protein; catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids; In the N-terminal section; belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.  In the 3rd section; belongs to the shikimate kinase family.  In the C-terminal section; belongs to the shikimate dehydrogenase family.


ensembl_gene_id: YDR128W
symbol: MTC5
gene_biotype: protein_coding
description:
  Maintenance of telomere capping protein 5; Subunit of SEACAT, a subcomplex of the SEA complex; Mtc1p, along with Rtc1p and Sea4p, redundantly inhibit the TORC1 inhibitory role of the Iml1p/SEACIT (Iml1p-Npr2p-Npr3p) subcomplex, a GAP for GTPase Gtr1p (EGOC subunit) in response to amino acid limitation, thereby resulting in activation of TORC1 signaling; SEA is a coatomer-related complex that associates dynamically with the vacuole; relative distribution to the vacuolar membrane decreases upon DNA replication stress.


ensembl_gene_id: YDR129C
symbol: SAC6
gene_biotype: protein_coding
description:
  Fimbrin, actin-bundling protein; cooperates with Scp1p in organization and maintenance of the actin cytoskeleton; phosphorylated by Cdc28p/Clb2p in metaphase on T103, to regulate conformation, and modulate actin filament binding affinity and actin cable dynamics; relocalizes from the plasma membrane to the cytoplasm upon DNA replication stress; human homologs PLS3 and LCP1 implicated in spinocerebellar ataxia type 2 (SCA2) can each complement yeast null mutant.


ensembl_gene_id: YDR130C
symbol: FIN1
gene_biotype: protein_coding
description:
  Filament protein FIN1; Spindle pole body-related intermediate filament protein; forms cell cycle-specific filaments between spindle pole bodies in dividing cells; localizes to poles and microtubules of spindle during anaphase and contributes to spindle stability; involved in Glc7p localization and regulation; relative distribution to the nucleus increases upon DNA replication stress.


ensembl_gene_id: YDR131C
symbol: YDR131C
gene_biotype: protein_coding
description:
  F-box protein subunit of SCF ubiquitin ligase complex; substrate-specific adaptor subunit that recruits substrates to a core ubiquitination complex.


ensembl_gene_id: YDR132C
symbol: YDR132C
gene_biotype: protein_coding
description:
  Uncharacterized protein YDR132C; Protein of unknown function; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; YDR132C has a paralog, YLR108C, that arose from the whole genome duplication.


ensembl_gene_id: YDR133C
symbol: YDR133C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YDR133C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps YDR134C.


ensembl_gene_id: YDR135C
symbol: YCF1
gene_biotype: protein_coding
description:
  Metal resistance protein YCF1; Vacuolar glutathione S-conjugate transporter; ABC-C transporter of the ATP-binding cassette family; required for vacuole fusion; forms stable complexes with vacuole fusion machinery; regulates Vam7p recruitment to vacuoles; role in detoxifying metals (Cd, Hg, As); transports GSSG that is not immediately reduced in cytosol to vacuole; transports unconjugated bilirubin, selenodigluthatione, oxidized glutathione; similar to human cystic fibrosis protein CFTR; Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.


ensembl_gene_id: YDR136C
symbol: VPS61
gene_biotype: protein_coding
description:
  Putative uncharacterized protein VPS61; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; 4% of ORF overlaps the verified gene RGP1; deletion causes a vacuolar protein sorting defect.


ensembl_gene_id: YDR137W
symbol: RGP1
gene_biotype: protein_coding
description:
  Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p); this complex catalyzes nucleotide exchange on Ypt6p; Belongs to the RGP1 family.


ensembl_gene_id: YDR138W
symbol: HPR1
gene_biotype: protein_coding
description:
  Subunit of THO/TREX complexes; this complex couple transcription elongation with mitotic recombination and with mRNA metabolism and export, subunit of an RNA Pol II complex; regulates lifespan; involved in telomere maintenance; similar to Top1p.


ensembl_gene_id: YDR139C
symbol: RUB1
gene_biotype: protein_coding
description:
  NEDD8-like protein RUB1; Ubiquitin-like protein with similarity to mammalian NEDD8; conjugation (neddylation) substrates include the cullins Cdc53p, Rtt101p, and Cul3p; activated by Ula1p and Uba3p (E1 enzyme pair); conjugation mediated by Ubc12p (E2 enzyme).


ensembl_gene_id: YDR140W
symbol: MTQ2
gene_biotype: protein_coding
description:
  eRF1 methyltransferase catalytic subunit MTQ2; S-adenosylmethionine-dependent methyltransferase; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC; member of the seven beta-strand family; Belongs to the eukaryotic/archaeal PrmC-related family.


ensembl_gene_id: YDR141C
symbol: DOP1
gene_biotype: protein_coding
description:
  Protein dopey; Golgi-localized, leucine-zipper domain containing protein; involved in endosome to Golgi transport, organization of the ER, establishing cell polarity, and morphogenesis; detected in highly purified mitochondria in high-throughput studies.


ensembl_gene_id: YDR142C
symbol: PEX7
gene_biotype: protein_coding
description:
  Peroxisomal signal receptor for peroxisomal matrix proteins; recognizes the N-terminal nonapeptide signal (PTS2); WD repeat protein; defects in human homolog cause lethal rhizomelic chondrodysplasia punctata (RCDP).


ensembl_gene_id: YDR143C
symbol: SAN1
gene_biotype: protein_coding
description:
  Ubiquitin-protein ligase; involved in proteasome-dependent degradation of aberrant nuclear proteins; targets substrates with regions of exposed hydrophobicity containing 5 or more contiguous hydrophobic residues; contains intrinsically disordered regions that contribute to substrate recognition; prefers a window of exposed hydrophobicity that causes a particular level of protein insolubility, suggesting that San1p evolved to target highly aggregation-prone proteins.


ensembl_gene_id: YDR144C
symbol: MKC7
gene_biotype: protein_coding
description:
  Aspartic proteinase MKC7; GPI-anchored aspartyl protease; member of the yapsin family of proteases involved in cell wall growth and maintenance; shares functions with Yap3p and Kex2p; MKC7 has a paralog, YPS1, that arose from the whole genome duplication.


ensembl_gene_id: YDR145W
symbol: TAF12
gene_biotype: protein_coding
description:
  Subunit (61/68 kDa) of TFIID and SAGA complexes; involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H2A; overexpression of the human ortholog, TAF12, an oncogene involved in the formation of choroid plexus carcinomas, results in dosage chromosomal instability (dCIN) in a human cell line similar to the dCIN observed in yeast overexpressors.


ensembl_gene_id: YDR146C
symbol: SWI5
gene_biotype: protein_coding
description:
  Transcriptional factor SWI5; Transcription factor that recruits Mediator and Swi/Snf complexes; activates transcription of genes expressed at the M/G1 phase boundary and in G1 phase; required for expression of the HO gene controlling mating type switching; localization to nucleus occurs during G1 and appears to be regulated by phosphorylation by Cdc28p kinase; SWI5 has a paralog, ACE2, that arose from the whole genome duplication.


ensembl_gene_id: YDR147W
symbol: EKI1
gene_biotype: protein_coding
description:
  Ethanolamine kinase; primarily responsible for phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; exhibits some choline kinase activity, thus contributing to phosphatidylcholine synthesis via the CDP-choline pathway; EKI1 has a paralog, CKI1, that arose from the whole genome duplication.


ensembl_gene_id: YDR148C
symbol: KGD2
gene_biotype: protein_coding
description:
  2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase); Dihydrolipoyl transsuccinylase; component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated.


ensembl_gene_id: YDR149C
symbol: YDR149C
gene_biotype: protein_coding
description:
  Putative uncharacterized membrane protein YDR149C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene NUM1/YDR150W; null mutation blocks anaerobic growth.


ensembl_gene_id: YDR150W
symbol: NUM1
gene_biotype: protein_coding
description:
  Protein required for nuclear migration; component of the mitochondria-ER-cortex-ancor (MECA); required for the association of mitochondria with the cell cortex and for accurate distribution of mitochondrial network; interacts with Mdm36p to link the ER and mitochondria at the cortex; localizes to the mother cell cortex and the bud tip; may mediate interactions of dynein and cytoplasmic microtubules with the cell cortex.


ensembl_gene_id: YDR151C
symbol: CTH1
gene_biotype: protein_coding
description:
  mRNA decay factor CTH1; Member of the CCCH zinc finger family; similar to mammalian Tis11 protein, which activates transcription and also has a role in mRNA degradation; may function with Tis11p in iron homeostasis; CTH1 has a paralog, TIS11, that arose from the whole genome duplication.


ensembl_gene_id: YDR152W
symbol: GIR2
gene_biotype: protein_coding
description:
  Protein GIR2; Highly-acidic RWD domain-containing cytoplasmic protein; forms a highly conserved complex with Rbg2p that is responsible for efficient cell growth under amino acid starvation and binds translational activator Gcn1p in dose-dependent manner according to stress level; associates with translating ribosomes; intrinsically unstructured protein whose stability is enhanced upon binding Rbg2p; Belongs to the RWDD1/GIR2 family.


ensembl_gene_id: YDR153C
symbol: ENT5
gene_biotype: protein_coding
description:
  Epsin-5; Protein containing an N-terminal epsin-like domain; involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p, clathrin adaptor complex AP-1, and clathrin.


ensembl_gene_id: YDR154C
symbol: YDR154C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YDR154C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; null mutant exhibits synthetic phenotype with alpha-synuclein.


ensembl_gene_id: YDR155C
symbol: CPR1
gene_biotype: protein_coding
description:
  Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds the drug cyclosporin A; N-terminally propionylated in vivo; protein abundance increases in response to DNA replication stress; Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.


ensembl_gene_id: YDR157W
symbol: YDR157W
gene_biotype: protein_coding
description:
  Uncharacterized protein YDR157W; Putative protein of unknown function; conserved across S. cerevisiae strains.


ensembl_gene_id: YDR158W
symbol: HOM2
gene_biotype: protein_coding
description:
  Aspartic beta semi-aldehyde dehydrogenase; catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis; Belongs to the aspartate-semialdehyde dehydrogenase family.


ensembl_gene_id: YDR159W
symbol: SAC3
gene_biotype: protein_coding
description:
  Nuclear mRNA export protein SAC3; mRNA export factor; required for biogenesis of the small ribosomal subunit; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; similar to the human germinal center-associated nuclear protein (GANP).


ensembl_gene_id: YDR160W
symbol: SSY1
gene_biotype: protein_coding
description:
  SPS-sensor component SSY1; Component of the SPS plasma membrane amino acid sensor system; senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes; other members are Ssy1p, Ptr3p, and Ssy5p.


ensembl_gene_id: YDR161W
symbol: ACL4
gene_biotype: protein_coding
description:
  Specific assembly chaperone for ribosomal protein Rpl4p; binds to an evolutionarily conserved surface extension of nascent Rpl4p and chaperones Rpl4p until its assembly into the pre-ribosome; transcriptionally co-regulated with rRNA and ribosome biosynthesis genes; Belongs to the ACL4 family.


ensembl_gene_id: YDR162C
symbol: NBP2
gene_biotype: protein_coding
description:
  NAP1-binding protein 2; Protein involved in the HOG (high osmolarity glycerol) pathway; negatively regulates Hog1p by recruitment of phosphatase Ptc1p the Pbs2p-Hog1p complex; interacts with Bck1p and down regulates the cell wall integrity pathway; found in the nucleus and cytoplasm, contains an SH3 domain and a Ptc1p binding domain (PBM).


ensembl_gene_id: YDR163W
symbol: CWC15
gene_biotype: protein_coding
description:
  Pre-mRNA-splicing factor CWC15; Non-essential protein involved in pre-mRNA splicing; component of a complex containing Cef1p; has similarity to S. pombe Cwf15p; Belongs to the CWC15 family.


ensembl_gene_id: YDR164C
symbol: SEC1
gene_biotype: protein_coding
description:
  Sm-like protein involved in docking and fusion of exocytic vesicles; binds to assembled SNARE complexes at the membrane and stimulates membrane fusion; localization to sites of secretion (bud neck and bud tip) is dependent on SNARE function; interacts directly with essential exocyst subunit Sec6p.


ensembl_gene_id: YDR165W
symbol: TRM82
gene_biotype: protein_coding
description:
  Catalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p; relocalizes to the cytosol in response to hypoxia; mutation in human ortholog WDR4 causes microcephalic primordial dwarfism.


ensembl_gene_id: YDR166C
symbol: SEC5
gene_biotype: protein_coding
description:
  Essential 107kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; involved in assembly of the exocyst complex; required with Sec3p for ER inheritance where it promotes anchoring of the cortical ER at the bud tip; Belongs to the SEC5 family.


ensembl_gene_id: YDR167W
symbol: TAF10
gene_biotype: protein_coding
description:
  Subunit (145 kDa) of TFIID and SAGA complexes; involved in RNA polymerase II transcription initiation and in chromatin modification.


ensembl_gene_id: YDR168W
symbol: CDC37
gene_biotype: protein_coding
description:
  Essential Hsp90p co-chaperone; necessary for passage through the START phase of the cell cycle; stabilizes protein kinase nascent chains and participates along with Hsp90p in their folding; Belongs to the CDC37 family.


ensembl_gene_id: YDR169C
symbol: STB3
gene_biotype: protein_coding
description:
  Protein STB3; Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress.


ensembl_gene_id: YDR169C-A
symbol: YDR169C-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YDR169C-A; Putative protein of unknown function; identified by fungal homology and RT-PCR.


ensembl_gene_id: YDR170C
symbol: SEC7
gene_biotype: protein_coding
description:
  Protein transport protein SEC7; Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors; involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport; found in the cytoplasm and on Golgi-associated coated vesicles.


ensembl_gene_id: YDR171W
symbol: HSP42
gene_biotype: protein_coding
description:
  Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress.


ensembl_gene_id: YDR172W
symbol: SUP35
gene_biotype: protein_coding
description:
  Eukaryotic peptide chain release factor GTP-binding subunit; Translation termination factor eRF3; has a role in mRNA deadenylation and decay; altered protein conformation creates the [PSI(+)] prion that modifies cellular fitness, alters translational fidelity by affecting reading frame selection, and results in a nonsense suppressor phenotype; many stress-response genes are repressed in the presence of [PSI(+)].


ensembl_gene_id: YDR173C
symbol: ARG82
gene_biotype: protein_coding
description:
  Inositol polyphosphate multikinase (IPMK); sequentially phosphorylates Ins(1,4,5)P3 to form Ins(1,3,4,5,6)P5; also has diphosphoinositol polyphosphate synthase activity; regulates arginine-, phosphate-, and nitrogen-responsive genes.


ensembl_gene_id: YDR174W
symbol: HMO1
gene_biotype: protein_coding
description:
  Chromatin associated high mobility group (HMG) family member; involved in compacting, bending, bridging and looping DNA; rDNA-binding component that regulates transcription from RNA polymerase I promoters; regulates start site selection of ribosomal protein genes via RNA polymerase II promoters; role in genome maintenance; associates with a 5'-3' DNA helicase and Fpr1p, a prolyl isomerase; relocalizes to the cytosol in response to hypoxia.


ensembl_gene_id: YDR176W
symbol: NGG1
gene_biotype: protein_coding
description:
  Subunit of chromatin modifying histone acetyltransferase complexes; member of the ADA complex, the SAGA complex, and the SLIK complex; transcriptional regulator involved in glucose repression of Gal4p-regulated genes.


ensembl_gene_id: YDR177W
symbol: UBC1
gene_biotype: protein_coding
description:
  Ubiquitin-conjugating enzyme; key E2 partner with Ubc4p for the anaphase-promoting complex (APC); mediates selective degradation of short-lived and abnormal proteins; plays a role in vesicle biogenesis and ER-associated protein degradation (ERAD); component of the cellular stress response; protein abundance increases in response to DNA replication stress key E2 partner with Ubc4p for the anaphase-promoting complex (APC).


ensembl_gene_id: YDR178W
symbol: SDH4
gene_biotype: protein_coding
description:
  Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial; Membrane anchor subunit of succinate dehydrogenase (SDH); involved in coupling the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; has similarity to human SDH subunit D (SDHD), which is implicated in paraganglioma.


ensembl_gene_id: YDR179C
symbol: CSN9
gene_biotype: protein_coding
description:
  Subunit of the Cop9 signalosome; Cop9 signalosome is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling.


ensembl_gene_id: YDR179W-A
symbol: NVJ3
gene_biotype: protein_coding
description:
  Uncharacterized protein YDR179W-A; Protein with a potential role in tethering ER and vacuoles; localizes to nucleus-vacuole junctions in an Mdm1p-dependent manner; contains a lipid-binding PXA domain.


ensembl_gene_id: YDR180W
symbol: SCC2
gene_biotype: protein_coding
description:
  Sister chromatid cohesion protein 2; Subunit of cohesin loading factor (Scc2p-Scc4p); a complex required for loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during DSB repair via histone H2AX; promotes gene expression program that supports translational fidelity; evolutionarily-conserved adherin; relocalizes to cytosol in response to hypoxia; human disorder Cornelia de Lange syndrome is caused by mutations in NIPBL, the human ortholog of SCC2.


ensembl_gene_id: YDR181C
symbol: SAS4
gene_biotype: protein_coding
description:
  Something about silencing protein 4; Subunit of the SAS complex (Sas2p, Sas4p, Sas5p); acetylates free histones and nucleosomes and regulates transcriptional silencing; required for the HAT activity of Sas2p.


ensembl_gene_id: YDR182W
symbol: CDC1
gene_biotype: protein_coding
description:
  Cell division control protein 1; Putative mannose-ethanolamine phosphate phosphodiesterase; involved in GPI-anchor remodeling prior to the attachment of cell wall proteins to beta 1,3-glucan, removing ethanolamine phosphate from the first mannose of GPI anchors; mutants display elevated Ca2+-dependent signaling resulting in secondary actin polarization and Golgi inheritance defects; enzyme is Mn2+-dependent; mutants have cell division cycle defect and fragile cell walls; Belongs to the metallophosphoesterase superfamily. MPPE1 family.


ensembl_gene_id: YDR182W-A
symbol: YDR182W-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YDR182W-A; Putative protein of unknown function; identified by fungal homology and RT-PCR.


ensembl_gene_id: YDR183C-A
symbol: YDR183C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YDR183C-A; Dubious open reading frame unlikely to encode a functional protein; identified by fungal homology and RT-PCR.


ensembl_gene_id: YDR183W
symbol: PLP1
gene_biotype: protein_coding
description:
  Phosducin-like protein 1; Protein that interacts with CCT (chaperonin containing TCP-1) complex; has a role in actin and tubulin folding; has weak similarity to phosducins, which are G-protein regulators; Belongs to the phosducin family.


ensembl_gene_id: YDR184C
symbol: ATC1
gene_biotype: protein_coding
description:
  Nuclear protein; possibly involved in regulation of cation stress responses and/or in the establishment of bipolar budding pattern; relative distribution to the nucleus decreases upon DNA replication stress.


ensembl_gene_id: YDR185C
symbol: UPS3
gene_biotype: protein_coding
description:
  Mitochondrial protein of unknown function; similar to Ups1p and Ups2p which are involved in regulation of mitochondrial cardiolipin and phosphatidylethanolamine levels; null is viable but interacts synthetically with ups1 and ups2 mutations; UPS3 has a paralog, UPS2, that arose from the whole genome duplication.


ensembl_gene_id: YDR186C
symbol: SND1
gene_biotype: protein_coding
description:
  Protein involved in SRP-independent targeting of substrates to the ER; component of an alternative ER targeting pathway that has partial functional redundancy with the GET pathway; preference for substrates with downstream transmembrane domains; interacts with Env10p/Snd2p and Pho88p/Snd3p; can compensate for loss of SRP; may interact with ribosomes, based on co-purification experiments; GFP-fusion protein localizes to the cytoplasm.


ensembl_gene_id: YDR187C
symbol: YDR187C
gene_biotype: protein_coding
description:
  Putative uncharacterized membrane protein YDR187C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF CCT6/YDR188W.


ensembl_gene_id: YDR188W
symbol: CCT6
gene_biotype: protein_coding
description:
  T-complex protein 1 subunit zeta; Subunit of the cytosolic chaperonin Cct ring complex; related to Tcp1p, essential protein that is required for the assembly of actin and tubulins in vivo; contains an ATP-binding motif.


ensembl_gene_id: YDR189W
symbol: SLY1
gene_biotype: protein_coding
description:
  Hydrophilic protein involved in ER/Golgi vesicle trafficking; SM (Sec1/Munc-18) family protein that binds the tSNARE Sed5p and stimulates its assembly into a trans-SNARE membrane-protein complex.


ensembl_gene_id: YDR190C
symbol: RVB1
gene_biotype: protein_coding
description:
  RuvB-like protein 1; ATP-dependent DNA helicase, also known as pontin; member of the AAA+ and RuvB-like protein families; similar to Rvb2p; conserved component of multiple complexes including the INO80 complex, the Swr1 complex, and the R2TP complex (Rvb1-Rvb2-Tah1-Pih1); involved in multiple processes such as chromatin remodeling, box C/D snoRNP assembly, and RNA polymerase II assembly.


ensembl_gene_id: YDR191W
symbol: HST4
gene_biotype: protein_coding
description:
  NAD-dependent histone deacetylase HST4; NAD(+)-dependent protein deacetylase; deacetylation targets are primarily mitochondrial proteins; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism; accumulates in mitochondria in response to biotin starvation and may link biotin metabolism with energy homeostasis; member of the Sir2 family and may be the functional equivalent of human SIRT3.


ensembl_gene_id: YDR192C
symbol: NUP42
gene_biotype: protein_coding
description:
  FG-nucleoporin component of central core of the nuclear pore complex; also part of the nuclear pore complex (NPC) cytoplasmic filaments; contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier and is involved in gene tethering at the nuclear periphery; interacts with Gle1p.


ensembl_gene_id: YDR193W
symbol: YDR193W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YDR193W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YDR194C
symbol: MSS116
gene_biotype: protein_coding
description:
  ATP-dependent RNA helicase MSS116, mitochondrial; Mitochondrial transcription elongation factor; DEAD-box protein; required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing; promotes RNA folding by stabilizing an early assembly intermediate.


ensembl_gene_id: YDR194W-A
symbol: YDR194W-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YDR194W-A; Putative protein of unknown function; identified by fungal homology and RT-PCR.


ensembl_gene_id: YDR195W
symbol: REF2
gene_biotype: protein_coding
description:
  RNA end formation protein 2; RNA-binding protein; involved in the cleavage step of mRNA 3'-end formation prior to polyadenylation, and in snoRNA maturation; part of holo-CPF subcomplex APT, which associates with 3'-ends of snoRNA- and mRNA-encoding genes; putative regulatory subunit of type 1 protein phosphatase Glc7p, required for actomyosin ring formation, and for timely dephosphorylation and release of Bnr1p from the division site; relocalizes to the cytosol in response to hypoxia.


ensembl_gene_id: YDR196C
symbol: CAB5
gene_biotype: protein_coding
description:
  Dephospho-CoA kinase CAB5; Subunit of the CoA-Synthesizing Protein Complex (CoA-SPC); subunits of this complex are: Cab2p, Cab3p, Cab4p, Cab5p, Sis2p and Vhs3p; probable dephospho-CoA kinase (DPCK) that catalyzes the last step in coenzyme A biosynthesis; null mutant lethality is complemented by human homolog DCAKD and by E. coli coaE (encoding DPCK); detected in purified mitochondria in high-throughput studies; also localized to lipid droplets.


ensembl_gene_id: YDR197W
symbol: CBS2
gene_biotype: protein_coding
description:
  Mitochondrial translational activator of the COB mRNA; interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader.


ensembl_gene_id: YDR198C
symbol: RKM2
gene_biotype: protein_coding
description:
  Ribosomal protein lysine methyltransferase; responsible for trimethylation of the lysine residue at position 3 of Rpl12Ap and Rpl12Bp; Belongs to the class V-like SAM-binding methyltransferase superfamily. RKM2 family.


ensembl_gene_id: YDR199W
symbol: YDR199W
gene_biotype: protein_coding
description:
  Putative uncharacterized membrane protein YDR199W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64/YDR200C; computationally predicted to have thiol-disulfide oxidoreductase activity.


ensembl_gene_id: YDR200C
symbol: VPS64
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 64; Protein required for cytoplasm to vacuole targeting of proteins; forms a complex with Far3p and Far7p to Far11p involved in recovery from pheromone-induced cell cycle arrest; mutant has increased aneuploidy tolerance; VPS64 has a paralog, FAR10, that arose from the whole genome duplication.


ensembl_gene_id: YDR201W
symbol: SPC19
gene_biotype: protein_coding
description:
  Essential subunit of the Dam1 complex (aka DASH complex); complex couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body.


ensembl_gene_id: YDR202C
symbol: RAV2
gene_biotype: protein_coding
description:
  Regulator of V-ATPase in vacuolar membrane protein 2; Subunit of RAVE complex (Rav1p, Rav2p, Skp1p); the RAVE complex associates with the V1 domain of the vacuolar membrane (H+)-ATPase (V-ATPase) and promotes assembly and reassembly of the holoenzyme.


ensembl_gene_id: YDR203W
symbol: YDR203W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YDR203W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF RAV2/YDR202C.


ensembl_gene_id: YDR204W
symbol: COQ4
gene_biotype: protein_coding
description:
  Protein with a role in ubiquinone (Coenzyme Q) biosynthesis; possibly functioning in stabilization of Coq7p; located on matrix face of mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex; human homolog COQ4 can complement yeast coq4 null mutant.


ensembl_gene_id: YDR205W
symbol: MSC2
gene_biotype: protein_coding
description:
  Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids.


ensembl_gene_id: YDR206W
symbol: EBS1
gene_biotype: protein_coding
description:
  Protein involved in translation inhibition and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors; EBS1 has a paralog, EST1, that arose from the whole genome duplication.


ensembl_gene_id: YDR207C
symbol: UME6
gene_biotype: protein_coding
description:
  Transcriptional regulatory protein UME6; Rpd3L histone deacetylase complex subunit; key transcriptional regulator of early meiotic genes; involved in chromatin remodeling and transcriptional repression via DNA looping; binds URS1 upstream regulatory sequence, represses transcription by recruiting conserved histone deacetylase Rpd3p (through co-repressor Sin3p) and chromatin-remodeling factor Isw2p; couples metabolic responses to nutritional cues with initiation and progression of meiosis, forms compl.


ensembl_gene_id: YDR208W
symbol: MSS4
gene_biotype: protein_coding
description:
  Phosphatidylinositol-4-phosphate 5-kinase; involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutation.


ensembl_gene_id: YDR209C
symbol: YDR209C
gene_biotype: protein_coding
description:
  Uncharacterized protein YDR209C; Putative protein of unknown function; conserved among S. cerevisiae strains; YDR209C is not an essential gene; partially overlaps uncharacterized gene YDR210W.


ensembl_gene_id: YDR210W
symbol: YDR210W
gene_biotype: protein_coding
description:
  Cysteine-rich and transmembrane domain-containing protein YDR210W; Predicted tail-anchored plasma membrane protein; contains a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; Belongs to the CYSTM1 family.


ensembl_gene_id: YDR211W
symbol: GCD6
gene_biotype: protein_coding
description:
  Catalytic epsilon subunit of the translation initiation factor eIF2B; eIF2B is the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression; forms cytoplasmic foci upon DNA replication stress; Belongs to the eIF-2B gamma/epsilon subunits family.


ensembl_gene_id: YDR212W
symbol: TCP1
gene_biotype: protein_coding
description:
  Alpha subunit of chaperonin-containing T-complex; complex mediates protein folding in the cytosol; involved in actin cytoskeleton maintenance; overexpression in neurons suppresses formation of pathogenic conformations of huntingtin protein.


ensembl_gene_id: YDR213W
symbol: UPC2
gene_biotype: protein_coding
description:
  Sterol uptake control protein 2; Sterol regulatory element binding protein; induces sterol biosynthetic genes, upon sterol depletion; acts as a sterol sensor, binding ergosterol in sterol rich conditions; relocates from intracellular membranes to perinuclear foci upon sterol depletion; redundant activator of filamentation with ECM22, up-regulating the expression of filamentous growth genes; contains a Zn[2]-Cys[6] binuclear cluster; UPC2 has a paralog, ECM22, that arose from the whole genome duplication.


ensembl_gene_id: YDR214W
symbol: AHA1
gene_biotype: protein_coding
description:
  Hsp90 co-chaperone AHA1; Co-chaperone that binds Hsp82p and activates its ATPase activity; plays a role in determining prion variants; similar to Hch1p; expression is regulated by stresses such as heat shock; protein abundance increases in response to DNA replication stress; Belongs to the AHA1 family.


ensembl_gene_id: YDR215C
symbol: YDR215C
gene_biotype: protein_coding
description:
  Uncharacterized protein YDR215C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein.


ensembl_gene_id: YDR216W
symbol: ADR1
gene_biotype: protein_coding
description:
  Regulatory protein ADR1; Carbon source-responsive zinc-finger transcription factor; required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization.


ensembl_gene_id: YDR217C
symbol: RAD9
gene_biotype: protein_coding
description:
  DNA damage-dependent checkpoint protein; required for cell-cycle arrest in G1/S, intra-S, and G2/M, plays a role in postreplication repair (PRR) pathway; transmits checkpoint signal by activating Rad53p and Chk1p; hyperphosphorylated by Mec1p and Tel1p; multiple cyclin dependent kinase consensus sites and the C-terminal BRCT domain contribute to DNA damage checkpoint activation; Rad9p Chk1 Activating Domain (CAD) is phosphorylated at multiple sites by Cdc28p/Clb2p.


ensembl_gene_id: YDR218C
symbol: SPR28
gene_biotype: protein_coding
description:
  Sporulation-regulated protein 28; Sporulation-specific homolog of the CDC3/10/11/12 family of genes; meiotic septin expressed at high levels during meiotic divisions and ascospore formation; the yeast CDC3/10/11/12 family is a family of bud neck microfilament genes; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.


ensembl_gene_id: YDR219C
symbol: MFB1
gene_biotype: protein_coding
description:
  Mitochondria-associated F-box protein; involved in maintenance of normal mitochondrial morphology; interacts with Skp1p through the F-box motif; preferentially localizes to the mother cell during budding.


ensembl_gene_id: YDR220C
symbol: YDR220C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YDR220C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; null mutant exhibits synthetic phenotype with alpha-synuclein.


ensembl_gene_id: YDR221W
symbol: GTB1
gene_biotype: protein_coding
description:
  Glucosidase II beta subunit, forms a complex with alpha subunit Rot2p; involved in removal of two glucose residues from N-linked glycans during glycoprotein biogenesis in the ER; relocalizes from ER to cytoplasm upon DNA replication stress.


ensembl_gene_id: YDR222W
symbol: YDR222W
gene_biotype: protein_coding
description:
  SVF1-like protein YDR222W; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YDR222W has a paralog, YLR225C, that arose from the whole genome duplication; Belongs to the SVF1 family.


ensembl_gene_id: YDR223W
symbol: CRF1
gene_biotype: protein_coding
description:
  Transcription factor CRF1; Transcriptional corepressor; involved in repression of ribosomal protein (RP) gene transcription via the TOR signaling pathway which promotes accumulation of Crf1p in the nucleus; role in repression of RP genes varies by strain; CRF1 has a paralog, IFH1, that arose from the whole genome duplication.


ensembl_gene_id: YDR224C
symbol: HTB1
gene_biotype: protein_coding
description:
  Histone H2B; core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB2; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates reassembly after DNA replication, transcriptional activation, meiotic DSB formation and H3 methylation.


ensembl_gene_id: YDR225W
symbol: HTA1
gene_biotype: protein_coding
description:
  Histone H2A; core histone protein required for chromatin assembly and chromosome function; one of two nearly identical subtypes (see also HTA2); DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p; N-terminally propionylated in vivo.


ensembl_gene_id: YDR226W
symbol: ADK1
gene_biotype: protein_coding
description:
  Adenylate kinase, required for purine metabolism; localized to the cytoplasm and the mitochondria; lacks cleavable signal sequence; protein abundance increases in response to DNA replication stress; mutations affecting Adk1p catalytic activity deregulate expression of phosphate utilization genes PHO5 and PHO84; human homolog AK1 can complement yeast adk1 mutant.


ensembl_gene_id: YDR227W
symbol: SIR4
gene_biotype: protein_coding
description:
  Regulatory protein SIR4; SIR protein involved in assembly of silent chromatin domains; silent information regulator (SIR) along with SIR2 and SIR3; involved in assembly of silent chromatin domains at telomeres and the silent mating-type loci; some alleles of SIR4 prolong lifespan; required for telomere hypercluster formation in quiescent yeast cells.


ensembl_gene_id: YDR228C
symbol: PCF11
gene_biotype: protein_coding
description:
  Protein PCF11; mRNA 3' end processing factor; essential component of cleavage and polyadenylation factor IA (CF IA), involved in pre-mRNA 3' end processing and in transcription termination; binds C-terminal domain of largest subunit of RNA pol II (Rpo21p); required for gene looping; relocalizes to the cytosol in response to hypoxia.


ensembl_gene_id: YDR229W
symbol: IVY1
gene_biotype: protein_coding
description:
  Protein IVY1; Phospholipid-binding protein that interacts with both Ypt7p and Vps33p; may partially counteract the action of Vps33p and vice versa, localizes to the rim of the vacuole as cells approach stationary phase.


ensembl_gene_id: YDR230W
symbol: YDR230W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YDR230W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20/YDR231C.


ensembl_gene_id: YDR231C
symbol: COX20
gene_biotype: protein_coding
description:
  Mitochondrial inner membrane protein; required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase; Belongs to the COX20 family.


ensembl_gene_id: YDR232W
symbol: HEM1
gene_biotype: protein_coding
description:
  5-aminolevulinate synthase, mitochondrial; 5-aminolevulinate synthase; catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p; has a pyridoxal phosphate cofactor whose insertion is mediated by Mcx1p; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.


ensembl_gene_id: YDR233C
symbol: RTN1
gene_biotype: protein_coding
description:
  Reticulon-like protein 1; Reticulon protein; involved in nuclear pore assembly and maintenance of tubular ER morphology; promotes membrane curvature; regulates the ER asymmetry-induced inheritance block during ER stress; role in ER-derived peroxisomal biogenesis; increases tubular ER when overexpressed; mutants have reduced phosphatidylserine transfer between the ER and mitochondria; interacts with exocyst subunit Sec6p, Yip3p, and Sbh1p; member of the RTNLA subfamily.


ensembl_gene_id: YDR234W
symbol: LYS4
gene_biotype: protein_coding
description:
  Homoaconitase, mitochondrial; Homoaconitase; catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway.


ensembl_gene_id: YDR235W
symbol: PRP42
gene_biotype: protein_coding
description:
  U1 small nuclear ribonucleoprotein component PRP42; U1 snRNP protein involved in splicing; required for U1 snRNP biogenesis; contains multiple tetriatricopeptide repeats.


ensembl_gene_id: YDR236C
symbol: FMN1
gene_biotype: protein_coding
description:
  Riboflavin kinase, produces riboflavin monophosphate (FMN); FMN is a necessary cofactor for many enzymes; predominantly localizes to the microsomal fraction and also found in the mitochondrial inner membrane; human RFK functionally complements the lethality of the null mutation.


ensembl_gene_id: YDR237W
symbol: MRPL7
gene_biotype: protein_coding
description:
  Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein.


ensembl_gene_id: YDR238C
symbol: SEC26
gene_biotype: protein_coding
description:
  Coatomer subunit beta; Essential beta-coat protein of the COPI coatomer; involved in ER-to-Golgi protein trafficking and maintenance of normal ER morphology; shares 43% sequence identity with mammalian beta-coat protein (beta-COP).


ensembl_gene_id: YDR239C
symbol: YDR239C
gene_biotype: protein_coding
description:
  Uncharacterized protein YDR239C; Protein of unknown function; may interact with ribosomes, based on co-purification experiments.


ensembl_gene_id: YDR240C
symbol: SNU56
gene_biotype: protein_coding
description:
  56 kDa U1 small nuclear ribonucleoprotein component; Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart; interacts with mRNA in commitment complex.


ensembl_gene_id: YDR241W
symbol: BUD26
gene_biotype: protein_coding
description:
  Putative uncharacterized protein BUD26; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; 1% of ORF overlaps the verified gene SNU56; diploid mutant displays a weak budding pattern phenotype in a systematic assay.


ensembl_gene_id: YDR243C
symbol: PRP28
gene_biotype: protein_coding
description:
  Pre-mRNA-splicing ATP-dependent RNA helicase PRP28; RNA binding protein; involved in RNA isomerization at the 5' splice site and for exchange of U6 for U1 snRNA at the 5' splice site; similar to the RNA helicases of the DEAD-box family.


ensembl_gene_id: YDR244W
symbol: PEX5
gene_biotype: protein_coding
description:
  Peroxisomal membrane signal receptor for peroxisomal matrix proteins; receptor for the C-terminal tripeptide signal sequence (PTS1) of peroxisomal matrix proteins; required for peroxisomal matrix protein import; also proposed to have PTS1-receptor independent functions.


ensembl_gene_id: YDR245W
symbol: MNN10
gene_biotype: protein_coding
description:
  Probable alpha-1,6-mannosyltransferase MNN10; Subunit of a Golgi mannosyltransferase complex; complex mediates elongation of the polysaccharide mannan backbone; membrane protein of the mannosyltransferase family; other members of the complex are Anp1p, Mnn9p, Mnn11p, and Hoc1p; Belongs to the glycosyltransferase 34 family.


ensembl_gene_id: YDR246W
symbol: TRS23
gene_biotype: protein_coding
description:
  Core component of transport protein particle (TRAPP) complexes I-III; TRAPP complexes are related multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p, regulating ER-Golgi traffic (TRAPPI), intra-Golgi traffic (TRAPPII), endosome-Golgi traffic (TRAPPII and III) and autophagy (TRAPPIII); human homolog is TRAPPC4.


ensembl_gene_id: YDR246W-A
symbol: YDR246W-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YDR246W-A; Putative protein of unknown function; identified by fungal homology and RT-PCR.


ensembl_gene_id: YDR247W
symbol: VHS1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase VHS1; Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; VHS1 has a paralog, SKS1, that arose from the whole genome duplication.


ensembl_gene_id: YDR248C
symbol: YDR248C
gene_biotype: protein_coding
description:
  Putative gluconokinase; sequence similarity to bacterial and human gluconokinase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; upregulated by deletion of the RNAP-II associated factor, PAF1.


ensembl_gene_id: YDR250C
symbol: YDR250C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YDR250C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YDR251W
symbol: PAM1
gene_biotype: protein_coding
description:
  Essential protein of unknown function; exhibits variable expression during colony morphogenesis; overexpression permits survival without protein phosphatase 2A, inhibits growth, and induces a filamentous phenotype; PAM1 has a paralog, SVL3, that arose from the whole genome duplication.


ensembl_gene_id: YDR252W
symbol: BTT1
gene_biotype: protein_coding
description:
  Heterotrimeric nascent polypeptide-associated complex beta3 subunit; complex binds ribosomes via its beta-subunits in close proximity to nascent polypeptides; interacts with Caf130p of the CCR4-NOT complex; similar to human BTF3; BTT1 has a paralog, EGD1, that arose from the whole genome duplication; Belongs to the NAC-beta family.


ensembl_gene_id: YDR253C
symbol: MET32
gene_biotype: protein_coding
description:
  Transcriptional regulator MET32; Zinc-finger DNA-binding transcription factor; involved in transcriptional regulation of the methionine biosynthetic genes; targets strong transcriptional activator Met4p to promoters of sulfur metabolic genes; feedforward loop exists in the regulation of genes controlled by Met4p and Met32p; lack of such a loop for MET31 may account for the differential actions of Met32p and Met31p; MET32 has a paralog, MET31, that arose from the whole genome duplication.


ensembl_gene_id: YDR254W
symbol: CHL4
gene_biotype: protein_coding
description:
  Inner kinetochore subunit CHL4; Outer kinetochore protein required for chromosome stability; involved in new kinetochore assembly and sister chromatid cohesion; forms a stable complex with Iml3p; peripheral component of the Ctf19 kinetochore complex that interacts with Ctf19p, Ctf3p, and Mif2p; required for the spindle assembly checkpoint; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-N and fission yeast mis15; Belongs to the CENP-N/CHL4 family.


ensembl_gene_id: YDR255C
symbol: RMD5
gene_biotype: protein_coding
description:
  E3 ubiquitin-protein ligase RMD5; Component of GID Complex that confers ubiquitin ligase (U3) activity; necessary for polyubiquitination and degradation of the gluconeogenic enzyme fructose-1,6-bisphosphatase; forms dimer with Fyv10p that is then recruited to GID Complex by Gid8p; also required for sporulation; conserved protein that has a degenerate RING finger domain.


ensembl_gene_id: YDR256C
symbol: CTA1
gene_biotype: protein_coding
description:
  Catalase A; breaks down hydrogen peroxide in the peroxisomal matrix formed by acyl-CoA oxidase (Pox1p) during fatty acid beta-oxidation; Belongs to the catalase family.


ensembl_gene_id: YDR257C
symbol: RKM4
gene_biotype: protein_coding
description:
  Ribosomal lysine methyltransferase; specific for monomethylation of Rpl42ap and Rpl42bp (lysine 55); nuclear SET-domain containing protein.


ensembl_gene_id: YDR258C
symbol: HSP78
gene_biotype: protein_coding
description:
  Heat shock protein 78, mitochondrial; Oligomeric mitochondrial matrix chaperone; cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; able to prevent the aggregation of misfolded proteins as well as resolubilize protein aggregates.


ensembl_gene_id: YDR259C
symbol: YAP6
gene_biotype: protein_coding
description:
  Basic leucine zipper (bZIP) transcription factor; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; overexpression increases sodium and lithium tolerance; computational analysis suggests a role in regulation of expression of genes involved in carbohydrate metabolism; YAP6 has a paralog, CIN5, that arose from the whole genome duplication.


ensembl_gene_id: YDR260C
symbol: SWM1
gene_biotype: protein_coding
description:
  Subunit of the anaphase-promoting complex (APC); APC is an E3 ubiquitin ligase that regulates the metaphase-anaphase transition and exit from mitosis; required for activation of the daughter-specific gene expression and spore wall maturation; Belongs to the APC13 family.


ensembl_gene_id: YDR261C
symbol: EXG2
gene_biotype: protein_coding
description:
  Glucan 1,3-beta-glucosidase 2; Exo-1,3-beta-glucanase; involved in cell wall beta-glucan assembly; may be anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor.


ensembl_gene_id: YDR262W
symbol: YDR262W
gene_biotype: protein_coding
description:
  FAS1 domain-containing protein YDR262W; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole and is induced in response to the DNA-damaging agent MMS; gene expression increases in response to Zymoliase treatment.


ensembl_gene_id: YDR263C
symbol: DIN7
gene_biotype: protein_coding
description:
  DNA damage-inducible protein DIN7; Mitochondrial nuclease functioning in DNA repair and replication; modulates the stability of the mitochondrial genome, induced by exposure to mutagens, also induced during meiosis at a time nearly coincident with commitment to recombination; DIN7 has a paralog, EXO1, that arose from the whole genome duplication; Belongs to the XPG/RAD2 endonuclease family.


ensembl_gene_id: YDR264C
symbol: AKR1
gene_biotype: protein_coding
description:
  Palmitoyltransferase AKR1; Palmitoyl transferase involved in protein palmitoylation; acts as a negative regulator of pheromone response pathway; required for endocytosis of pheromone receptors; involved in cell shape control; contains ankyrin repeats; AKR1 has a paralog, AKR2, that arose from the whole genome duplication; any of several human homologs encoding DHHC-type zinc fingers (ZDHHC) can complement temperature sensitivity of yeast akr1 null mutant; Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.


ensembl_gene_id: YDR265W
symbol: PEX10
gene_biotype: protein_coding
description:
  Peroxisome biogenesis factor 10; Peroxisomal membrane E3 ubiquitin ligase; required for for Ubc4p-dependent Pex5p ubiquitination and peroxisomal matrix protein import; contains zinc-binding RING domain; mutations in human homolog cause various peroxisomal disorders.


ensembl_gene_id: YDR266C
symbol: HEL2
gene_biotype: protein_coding
description:
  RING finger ubiquitin ligase (E3); involved in ubiquitination and degradation of excess histones; interacts with Ubc4p and Rad53p; null mutant sensitive to hydroxyurea (HU); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; computational analysis suggests a role as a transcription factor.


ensembl_gene_id: YDR267C
symbol: CIA1
gene_biotype: protein_coding
description:
  Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at late step of Fe-S cluster assembly; forms CIA targeting complex with Cia2p and Met18p that directs Fe-S cluster incorporation into subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, telomere maintenance; contains WD40 repeats; human homolog CIAO1 can complement yeast cia1 null mutant.


ensembl_gene_id: YDR268W
symbol: MSW1
gene_biotype: protein_coding
description:
  Tryptophan--tRNA ligase, mitochondrial; Mitochondrial tryptophanyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.


ensembl_gene_id: YDR269C
symbol: YDR269C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YDR269C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YDR270W
symbol: CCC2
gene_biotype: protein_coding
description:
  Cu(+2)-transporting P-type ATPase; required for export of copper from the cytosol into an extracytosolic compartment; similar to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism; human homologs ATP7A and ATP7B both complement yeast null mutant.


ensembl_gene_id: YDR271C
symbol: YDR271C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YDR271C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CCC2/YDR270W.


ensembl_gene_id: YDR272W
symbol: GLO2
gene_biotype: protein_coding
description:
  Hydroxyacylglutathione hydrolase, cytoplasmic isozyme; Cytoplasmic glyoxalase II; catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate; GLO2 has a paralog, GLO4, that arose from the whole genome duplication.


ensembl_gene_id: YDR273W
symbol: DON1
gene_biotype: protein_coding
description:
  Donuts protein 1; Meiosis-specific component of the spindle pole body; subunit of the leading edge protein (LEP) complex (Ssp1-Ady3-Don1-Irc10) that forms a ring-like structure at the leading edge of the prospore membrane (PSM) during meiosis II; required for PSM growth and closure; DON1 has a paralog, CUE5, that arose from the whole genome.


ensembl_gene_id: YDR274C
symbol: YDR274C
gene_biotype: protein_coding
description:
  Uncharacterized protein YDR274C; Putative protein of unknown function; conserved among S. cerevisiae strains; YDR274C is not an essential gene.


ensembl_gene_id: YDR275W
symbol: BSC2
gene_biotype: protein_coding
description:
  Bypass of stop codon protein 2; Protein of unknown function; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; null mutant displays increased translation rate and increased readthrough of premature stop codons; BSC2 has a paralog, IRC23, that arose from the whole genome duplication.


ensembl_gene_id: YDR276C
symbol: PMP3
gene_biotype: protein_coding
description:
  Small plasma membrane protein; confers resistance to amphotericin B and is a potential target of this common antifungal drug; related to a family of plant polypeptides that are overexpressed under high salt concentration or low temperature; not essential for viability; deletion causes hyperpolarization of the plasma membrane potential; Belongs to the UPF0057 (PMP3) family.


ensembl_gene_id: YDR277C
symbol: MTH1
gene_biotype: protein_coding
description:
  Protein MTH1; Negative regulator of the glucose-sensing signal transduction pathway; required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation; MTH1 has a paralog, STD1, that arose from the whole genome duplication.


ensembl_gene_id: YDR278C
symbol: YDR278C
gene_biotype: protein_coding
description:
  Uncharacterized protein YDR278C; Putative protein of unknown function; conserved among S. cerevisiae strains; YDR278C is not an essential gene.


ensembl_gene_id: YDR279W
symbol: RNH202
gene_biotype: protein_coding
description:
  Ribonuclease H2 subunit; required for RNase H2 activity; role in ribonucleotide excision repair; related to human AGS2 that causes Aicardi-Goutieres syndrome.


ensembl_gene_id: YDR280W
symbol: RRP45
gene_biotype: protein_coding
description:
  Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9); protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YDR281C
symbol: PHM6
gene_biotype: protein_coding
description:
  Phosphate metabolism protein 6; Protein of unknown function; expression is regulated by phosphate levels.


ensembl_gene_id: YDR282C
symbol: MRX10
gene_biotype: protein_coding
description:
  MIOREX complex component 10; Mitochondrial inner membrane protein of unknown function; associates with mitochondrial ribosome; localizes to the inner membrane with the C terminus facing the intermembrane space; ortholog of human RMND1, mutation in which is implicated in infantile encephaloneuromyopathy and defective mitochondrial translation.


ensembl_gene_id: YDR283C
symbol: GCN2
gene_biotype: protein_coding
description:
  eIF-2-alpha kinase GCN2; Protein kinase; phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; contributes to DNA damage checkpoint control.


ensembl_gene_id: YDR284C
symbol: DPP1
gene_biotype: protein_coding
description:
  Diacylglycerol pyrophosphate (DGPP) phosphatase; zinc-regulated vacuolar membrane-associated lipid phosphatase, dephosphorylates DGPP to phosphatidate (PA) and Pi, then PA to diacylglycerol; involved in lipid signaling and cell metabolism; Belongs to the PA-phosphatase related phosphoesterase family.


ensembl_gene_id: YDR285W
symbol: ZIP1
gene_biotype: protein_coding
description:
  Transverse filament protein of the synaptonemal complex; required for normal levels of meiotic recombination and pairing between homologous chromosome during meiosis; required for meiotic recombination between non-allelc sites; potential Cdc28p substrate.


ensembl_gene_id: YDR286C
symbol: YDR286C
gene_biotype: protein_coding
description:
  Glutaredoxin-like protein YDR286C; Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site; Belongs to the glutaredoxin family. YDR286C subfamily.


ensembl_gene_id: YDR287W
symbol: INM2
gene_biotype: protein_coding
description:
  Inositol monophosphatase; involved in biosynthesis of inositol; enzymatic activity requires magnesium ions and is inhibited by lithium and sodium ions; inm1 inm2 double mutant lacks inositol auxotrophy.


ensembl_gene_id: YDR288W
symbol: NSE3
gene_biotype: protein_coding
description:
  Non-structural maintenance of chromosome element 3; Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YDR289C
symbol: RTT103
gene_biotype: protein_coding
description:
  Regulator of Ty1 transposition protein 103; Protein involved in transcription termination by RNA polymerase II; interacts with exonuclease Rat1p and Rai1p; has an RPR domain (carboxy-terminal domain interacting domain); also involved in regulation of Ty1 transposition; Belongs to the UPF0400 (RTT103) family.


ensembl_gene_id: YDR290W
symbol: YDR290W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YDR290W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RTT103.


ensembl_gene_id: YDR291W
symbol: HRQ1
gene_biotype: protein_coding
description:
  ATP-dependent helicase HRQ1; 3'-5' DNA helicase that has DNA strand annealing activity; helicase activity is stimulated by fork structure and 3'-tail length of substrates; acts with Rad4p in nucleotide-excision repair; belongs to the widely conserved RecQ family of proteins which are involved in maintaining genomic integrity; similar to the human RecQ4p implicated in Rothmund-Thomson syndrome (RTS).


ensembl_gene_id: YDR292C
symbol: SRP101
gene_biotype: protein_coding
description:
  Signal recognition particle (SRP) receptor alpha subunit; contain GTPase domains; involved in SRP-dependent protein targeting; interacts with the beta subunit, Srp102p.


ensembl_gene_id: YDR293C
symbol: SSD1
gene_biotype: protein_coding
description:
  Protein SSD1; Translational repressor with a role in polar growth and wall integrity; regulated by Cbk1p phosphorylation to effect bud-specific translational control and localization of specific mRNAs; interacts with TOR pathway components; contains a functional N-terminal nuclear localization sequence and nucleocytoplasmic shuttling appears to be critical to Ssd1p function; Belongs to the RNR ribonuclease family.


ensembl_gene_id: YDR294C
symbol: DPL1
gene_biotype: protein_coding
description:
  Dihydrosphingosine phosphate lyase; regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs), degrades phosphorylated long chain bases, prefers C16 dihydrosphingosine-l-phosphate as a substrate.


ensembl_gene_id: YDR295C
symbol: HDA2
gene_biotype: protein_coding
description:
  Subunit of the HDA1 histone deacetylase complex; possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex contains Hda1p homodimer and an Hda2p-Hda3p heterodimer; involved in telomere maintenance; relocalizes to the cytosol in response to hypoxia.


ensembl_gene_id: YDR296W
symbol: MHR1
gene_biotype: protein_coding
description:
  Mitochondrial ribosomal protein of the large subunit; also involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress.


ensembl_gene_id: YDR297W
symbol: SUR2
gene_biotype: protein_coding
description:
  Sphingolipid C4-hydroxylase SUR2; Sphinganine C4-hydroxylase; catalyses the conversion of sphinganine to phytosphingosine in sphingolipid biosyntheis; Belongs to the sterol desaturase family.


ensembl_gene_id: YDR298C
symbol: ATP5
gene_biotype: protein_coding
description:
  Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated; Belongs to the ATPase delta chain family.


ensembl_gene_id: YDR299W
symbol: BFR2
gene_biotype: protein_coding
description:
  Protein BFR2; Component of the SSU and 90S preribosomes; involved in pre-18S rRNA processing; binds to U3 snoRNA and Mpp10p; multicopy suppressor of sensitivity to Brefeldin A; expression is induced during lag phase and also by cold shock.


ensembl_gene_id: YDR300C
symbol: PRO1
gene_biotype: protein_coding
description:
  Glutamate 5-kinase; Gamma-glutamyl kinase; catalyzes the first step in proline biosynthesis; required for nitrogen starvation-induced ribophagy but not for nonselective autophagy; PRO1 has a paralog, YHR033W, that arose from the whole genome duplication; Belongs to the glutamate 5-kinase family.


ensembl_gene_id: YDR301W
symbol: CFT1
gene_biotype: protein_coding
description:
  Protein CFT1; RNA-binding subunit of the mRNA cleavage and polyadenylation factor; involved in poly(A) site recognition and required for both pre-mRNA cleavage and polyadenylation, 51% sequence similarity with mammalian AAUAA-binding subunit of CPSF.


ensembl_gene_id: YDR302W
symbol: GPI11
gene_biotype: protein_coding
description:
  Glycosylphosphatidylinositol anchor biosynthesis protein 11; ER membrane protein involved in a late step of GPI anchor assembly; involved in the addition of phosphoethanolamine to the multiply mannosylated glycosylphosphatidylinositol (GPI) intermediate; human PIG-Fp is a functional homolog.


ensembl_gene_id: YDR303C
symbol: RSC3
gene_biotype: protein_coding
description:
  Chromatin structure-remodeling complex protein RSC3; Component of the RSC chromatin remodeling complex; essential gene required for maintenance of proper ploidy and regulation of ribosomal protein genes and the cell wall/stress response; RSC3 has a paralog, RSC30, that arose from the whole genome duplication.


ensembl_gene_id: YDR304C
symbol: CPR5
gene_biotype: protein_coding
description:
  Peptidyl-prolyl cis-trans isomerase (cyclophilin) of the ER; catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; transcriptionally induced in response to unfolded proteins in the ER; CPR5 has a paralog, CPR2, that arose from the whole genome duplication.


ensembl_gene_id: YDR305C
symbol: HNT2
gene_biotype: protein_coding
description:
  Bis(5'-adenosyl)-triphosphatase; Dinucleoside triphosphate hydrolase; has similarity to the tumor suppressor FHIT and belongs to the histidine triad (HIT) superfamily of nucleotide-binding proteins.


ensembl_gene_id: YDR307W
symbol: PMT7
gene_biotype: protein_coding
description:
  Probable dolichyl-phosphate-mannose--protein mannosyltransferase 7; Putative protein mannosyltransferase similar to Pmt1p; has a potential role in protein O-glycosylation.


ensembl_gene_id: YDR308C
symbol: SRB7
gene_biotype: protein_coding
description:
  Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; target of the global repressor Tup1p.


ensembl_gene_id: YDR309C
symbol: GIC2
gene_biotype: protein_coding
description:
  GTPase-interacting component 2; Redundant rho-like GTPase Cdc42p effector; involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain and with PI(4,5)P2 via a polybasic region; GIC2 has a paralog, GIC1, that arose from the whole genome duplication.


ensembl_gene_id: YDR310C
symbol: SUM1
gene_biotype: protein_coding
description:
  Suppressor of mar1-1 protein; Transcriptional repressor that regulates middle-sporulation genes; required for mitotic repression of middle sporulation-specific genes; also acts as general replication initiation factor; involved in telomere maintenance, chromatin silencing; regulated by pachytene checkpoint.


ensembl_gene_id: YDR311W
symbol: TFB1
gene_biotype: protein_coding
description:
  Subunit of TFIIH and nucleotide excision repair factor 3 complexes; required for nucleotide excision repair, target for transcriptional activators; relocalizes to the cytosol in response to hypoxia.


ensembl_gene_id: YDR312W
symbol: SSF2
gene_biotype: protein_coding
description:
  Ribosome biogenesis protein SSF2; Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication.


ensembl_gene_id: YDR313C
symbol: PIB1
gene_biotype: protein_coding
description:
  E3 ubiquitin-protein ligase PIB1; RING-type ubiquitin ligase of the endosomal and vacuolar membranes; binds phosphatidylinositol(3)-phosphate; contains a FYVE finger domain.


ensembl_gene_id: YDR315C
symbol: IPK1
gene_biotype: protein_coding
description:
  Inositol 1,3,4,5,6-pentakisphosphate 2-kinase; nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable; human IPPK can complement ipk1 null mutant.


ensembl_gene_id: YDR316W
symbol: OMS1
gene_biotype: protein_coding
description:
  Methyltransferase OMS1, mitochondrial; Protein integral to the mitochondrial membrane; has a conserved methyltransferase motif and is predicted to be an RNA methyltransferase; multicopy suppressor of respiratory defects caused by OXA1 mutations.


ensembl_gene_id: YDR318W
symbol: MCM21
gene_biotype: protein_coding
description:
  Inner kinetochore subunit MCM21; Component of the kinetochore sub-complex COMA; COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) bridges kinetochore subunits in contact with centromeric DNA with subunits bound to microtubules during kinetochore assembly; involved in minichromosome maintenance; modified by sumoylation; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-O and fission yeast mal2; Belongs to the CENP-O/MCM21 family.


ensembl_gene_id: YDR319C
symbol: YFT2
gene_biotype: protein_coding
description:
  FIT family protein YFT2; Protein required for normal ER membrane biosynthesis; member of the highly conserved FIT family of proteins involved in triglyceride droplet biosynthesis and homologous to human FIT2; interacts with Sst2p and Hsp82p in high-throughput two-hybrid screens.


ensembl_gene_id: YDR320C
symbol: SWA2
gene_biotype: protein_coding
description:
  Auxilin-like clathrin uncoating factor SWA2; Auxilin-like protein involved in vesicular transport; clathrin-binding protein required for uncoating of clathrin-coated vesicles.


ensembl_gene_id: YDR320W-B
symbol: YDR320W-B
gene_biotype: protein_coding
description:
  Uncharacterized protein YDR320W-B; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene DAD4/YDR320C-A.


ensembl_gene_id: YDR321W
symbol: ASP1
gene_biotype: protein_coding
description:
  Cytosolic L-asparaginase, involved in asparagine catabolism; catalyzes hydrolysis of L-asparagine to aspartic acid and ammonia; important enzyme for the treatment of acute lymphoblastic leukemia; has low glutaminase activity and dependence; synthesized constitutively.


ensembl_gene_id: YDR322C-A
symbol: TIM11
gene_biotype: protein_coding
description:
  Subunit e of mitochondrial F1F0-ATPase; ATPase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; essential for the dimeric and oligomeric state of ATP synthase, which in turn determines the shape of inner membrane cristae.


ensembl_gene_id: YDR322W
symbol: MRPL35
gene_biotype: protein_coding
description:
  Mitochondrial ribosomal protein of the large subunit; Belongs to the phosphatidylethanolamine-binding protein family. Mitochondrion-specific ribosomal protein mL38 subfamily.


ensembl_gene_id: YDR323C
symbol: PEP7
gene_biotype: protein_coding
description:
  Adaptor protein involved in vesicle-mediated vacuolar protein sorting; multivalent adaptor protein; facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance.


ensembl_gene_id: YDR324C
symbol: UTP4
gene_biotype: protein_coding
description:
  U3 small nucleolar RNA-associated protein 4; Subunit of U3-containing 90S preribosome and SSU processome complexes; involved in production of 18S rRNA and assembly of small ribosomal subunit; member of t-Utp subcomplex involved with transcription of 35S rRNA transcript; Small Subunit processome is also known as SSU processome.


ensembl_gene_id: YDR325W
symbol: YCG1
gene_biotype: protein_coding
description:
  Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation and chromatin binding by the complex; required for tRNA genes clustering at the nucleolus; required for replication slow zone breakage following Mec1p inactivation; transcription is cell cycle regulated, peaking in mitosis and declining in G1; protein is constitutively degraded by the proteasome; rate limiting for condensin recruitment to chromatin.


ensembl_gene_id: YDR326C
symbol: YSP2
gene_biotype: protein_coding
description:
  Membrane-anchored lipid-binding protein YSP2; Sterol-binding protein; has a probable role in retrograde transport of sterols from the plasma membrane to the ER; contains two StART-like domains that bind sterols and a GRAM domain; co-localizes to puncta in the cortical ER with Sip3p; one of six StART-like domain-containing proteins in yeast that may be involved in sterol transfer between intracellular membranes; conserved across eukaryotes.


ensembl_gene_id: YDR327W
symbol: YDR327W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YDR327W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SKP1.


ensembl_gene_id: YDR328C
symbol: SKP1
gene_biotype: protein_coding
description:
  Evolutionarily conserved kinetochore protein; part of multiple protein complexes, including the SCF ubiquitin ligase complex, the CBF3 complex that binds centromeric DNA, and the RAVE complex that regulates assembly of the V-ATPase; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YDR329C
symbol: PEX3
gene_biotype: protein_coding
description:
  Peroxisomal biogenesis factor 3; Peroxisomal membrane protein (PMP); required for proper localization and stability of PMPs; anchors peroxisome retention factor Inp1p at the peroxisomal membrane; interacts with Pex19p.


ensembl_gene_id: YDR330W
symbol: UBX5
gene_biotype: protein_coding
description:
  UBX domain-containing protein that interacts with Cdc48p; ubiquitin regulatory X is also known as UBX.


ensembl_gene_id: YDR331W
symbol: GPI8
gene_biotype: protein_coding
description:
  GPI-anchor transamidase; ER membrane glycoprotein subunit of the GPI transamidase complex; adds glycosylphosphatidylinositol (GPI) anchors to newly synthesized proteins; human PIG-K protein is a functional homolog.


ensembl_gene_id: YDR332W
symbol: IRC3
gene_biotype: protein_coding
description:
  Putative ATP-dependent helicase IRC3; Double-stranded DNA-dependent helicase of the DExH/D-box family; required for maintenance of the mitochondrial (mt) genome; null mutant accumulates double-stranded breaks in mt DNA; localizes to the mt matrix; Belongs to the helicase family. IRC3 subfamily.


ensembl_gene_id: YDR333C
symbol: RQC1
gene_biotype: protein_coding
description:
  Component of the ribosome quality control complex (RQC); RQC (Rqc1p-Rkr1p-Tae2p-Cdc48p-Npl4p-Ufd1p) is a ribosome-bound complex required for the degradation of polypeptides arising from stalled translation; required along with Rkr1p for recruitment of the Cdc48p-Npl4p-Ufd1p AAA ATPase complex to the RQC; Belongs to the TCF25 family.


ensembl_gene_id: YDR334W
symbol: SWR1
gene_biotype: protein_coding
description:
  Helicase SWR1; Swi2/Snf2-related ATPase; structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; relocalizes to the cytosol in response to hypoxia; chronological aging factor that mediates lifespan extension by dietary restriction; Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.


ensembl_gene_id: YDR335W
symbol: MSN5
gene_biotype: protein_coding
description:
  Protein MSN5; Karyopherin; involved in nuclear import and export of proteins, including import of replication protein A and export of Far1p and transcription factors Swi5p, Swi6p, Msn2p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm; exportin-5 homolog.


ensembl_gene_id: YDR336W
symbol: MRX8
gene_biotype: protein_coding
description:
  MIOREX complex component 8; Protein that associates with mitochondrial ribosome; sumoylated under stress conditions in a genome wide study; YDR336W is not an essential gene.


ensembl_gene_id: YDR338C
symbol: YDR338C
gene_biotype: protein_coding
description:
  Uncharacterized transporter YDR338C; Putative protein of unknown function; member of the multi-drug and toxin extrusion (MATE) family of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily.


ensembl_gene_id: YDR339C
symbol: FCF1
gene_biotype: protein_coding
description:
  rRNA-processing protein FCF1; Putative PINc domain nuclease; required for early cleavages of 35S pre-rRNA and maturation of 18S rRNA; component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; copurifies with Faf1p.


ensembl_gene_id: YDR341C
symbol: YDR341C
gene_biotype: protein_coding
description:
  Arginine--tRNA ligase, cytoplasmic; Arginyl-tRNA synthetase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDR341C has a paralog, MSR1, that arose from the whole genome duplication.


ensembl_gene_id: YDR342C
symbol: HXT7
gene_biotype: protein_coding
description:
  High-affinity glucose transporter; member of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels; HXT7 has a paralog, HXT4, that arose from the whole genome duplication.


ensembl_gene_id: YDR343C
symbol: HXT6
gene_biotype: protein_coding
description:
  High-affinity glucose transporter; member of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3; HXT6 has a paralog, HXT1, that arose from the whole genome duplication; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.


ensembl_gene_id: YDR344C
symbol: YDR344C
gene_biotype: protein_coding
description:
  Uncharacterized protein YDR344C; Putative protein of unknown function; conserved among S. cerevisiae strains.


ensembl_gene_id: YDR345C
symbol: HXT3
gene_biotype: protein_coding
description:
  Low affinity glucose transporter of the major facilitator superfamily; expression is induced in low or high glucose conditions; HXT3 has a paralog, HXT5, that arose from the whole genome duplication.


ensembl_gene_id: YDR346C
symbol: SVF1
gene_biotype: protein_coding
description:
  Survival factor 1; Protein with a potential role in cell survival pathways; required for the diauxic growth shift; expression in mammalian cells increases survival under conditions inducing apoptosis; mutant has increased aneuploidy tolerance; Belongs to the SVF1 family.


ensembl_gene_id: YDR347W
symbol: MRP1
gene_biotype: protein_coding
description:
  Mitochondrial ribosomal protein of the small subunit; MRP1 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator, and with PET123, encoding a small subunit mitochondrial ribosomal protein.


ensembl_gene_id: YDR348C
symbol: PAL1
gene_biotype: protein_coding
description:
  Protein of unknown function thought to be involved in endocytosis; physically interacts with Ede1p and is found at endocytic sites at cell periphery during early stages of endocytosis; green fluorescent protein (GFP)-fusion protein localizes to bud neck; potential Cdc28p substrate; similar to S. pombe Pal1 protein; relocalizes from bud neck to cytoplasm upon DNA replication stress; PAL1 has a paralog, YHR097C, that arose from the whole genome duplication.


ensembl_gene_id: YDR349C
symbol: YPS7
gene_biotype: protein_coding
description:
  Aspartic proteinase yapsin-7; Putative GPI-anchored aspartic protease; member of the yapsin family of proteases involved in cell wall growth and maintenance; located in the cytoplasm and endoplasmic reticulum; Belongs to the peptidase A1 family.


ensembl_gene_id: YDR350C
symbol: ATP22
gene_biotype: protein_coding
description:
  Specific translational activator for the mitochondrial ATP6 mRNA; Atp6p encodes a subunit of F1F0 ATP synthase; localized to the mitochondrial inner membrane; Belongs to the ATP22 family.


ensembl_gene_id: YDR351W
symbol: SBE2
gene_biotype: protein_coding
description:
  Protein required for bud growth; involved in transport of cell wall components from the Golgi to the cell surface; SBE2 has a paralog, SBE22, that arose from the whole genome duplication.


ensembl_gene_id: YDR352W
symbol: YPQ2
gene_biotype: protein_coding
description:
  Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; member of the PQ-loop family, with seven transmembrane domains; mutant phenotype is functionally complemented by rat PQLC2 vacuolar transporter; Belongs to the laat-1 family.


ensembl_gene_id: YDR353W
symbol: TRR1
gene_biotype: protein_coding
description:
  Cytoplasmic thioredoxin reductase; key regulatory enzyme that determines the redox state of the thioredoxin system, which acts as a disulfide reductase system and protects cells against both oxidative and reductive stress; protein abundance increases in response to DNA replication stress; TRR1 has a paralog, TRR2, that arose from the whole genome duplication; Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.


ensembl_gene_id: YDR354C-A
symbol: YDR354C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YDR354C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps TRP4; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching.


ensembl_gene_id: YDR354W
symbol: TRP4
gene_biotype: protein_coding
description:
  Anthranilate phosphoribosyl transferase; transferase of the tryptophan biosynthetic pathway; catalyzes the phosphoribosylation of anthranilate; subject to the general control system of amino acid biosynthesis.


ensembl_gene_id: YDR355C
symbol: YDR355C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YDR355C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified essential ORF SPC110/YDR356W.


ensembl_gene_id: YDR356W
symbol: SPC110
gene_biotype: protein_coding
description:
  Inner plaque spindle pole body (SPB) component; ortholog of human kendrin; gamma-tubulin small complex (gamma-TuSC) receptor that interacts with Spc98p to recruit the complex to the nuclear side of the SPB, connecting nuclear microtubules to the SPB; promotes gamma-TuSC assembly and oligomerization to initiate microtubule nucleation; interacts with Tub4p-complex and calmodulin; phosphorylated by Mps1p in cell cycle-dependent manner.


ensembl_gene_id: YDR357C
symbol: CNL1
gene_biotype: protein_coding
description:
  Subunit of the BLOC-1 complex involved in endosomal maturation; interacts with Msb3p; null mutant is sensitive to drug inducing secretion of vacuolar cargo; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; Belongs to the BLOC1S4 family.


ensembl_gene_id: YDR358W
symbol: GGA1
gene_biotype: protein_coding
description:
  ADP-ribosylation factor-binding protein GGA1; Golgi-localized protein with homology to gamma-adaptin; interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner in order to facilitate traffic through the late Golgi; GGA1 has a paralog, GGA2, that arose from the whole genome duplication.


ensembl_gene_id: YDR359C
symbol: EAF1
gene_biotype: protein_coding
description:
  Chromatin modification-related protein EAF1; Component of the NuA4 histone acetyltransferase complex; acts as a platform for assembly of NuA4 subunits into the native complex; required for initiation of pre-meiotic DNA replication, likely due to its requirement for expression of IME1; Belongs to the EAF1 family.


ensembl_gene_id: YDR360W
symbol: OPI7
gene_biotype: protein_coding
description:
  Putative uncharacterized protein OPI7; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified gene VID21/YDR359C.


ensembl_gene_id: YDR361C
symbol: BCP1
gene_biotype: protein_coding
description:
  Essential protein involved in nuclear export of Mss4p; Mss4p is a lipid kinase that generates phosphatidylinositol 4,5-biphosphate and plays a role in actin cytoskeleton organization and vesicular transport; Belongs to the BCP1 family.


ensembl_gene_id: YDR362C
symbol: TFC6
gene_biotype: protein_coding
description:
  Subunit of RNA polymerase III transcription initiation factor complex; one of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; cooperates with Tfc3p in DNA binding; human homolog is TFIIIC-110.


ensembl_gene_id: YDR363W
symbol: ESC2
gene_biotype: protein_coding
description:
  Sumo-like domain protein; prevents accumulation of toxic intermediates during replication-associated recombinational repair; roles in silencing, lifespan, chromatid cohesion and the intra-S-phase DNA damage checkpoint; RENi family member.


ensembl_gene_id: YDR363W-A
symbol: SEM1
gene_biotype: protein_coding
description:
  26S proteasome complex subunit SEM1; 19S proteasome regulatory particle lid subcomplex component; role in Ub-dependent proteolysis and proteasome stability; involved in TREX-2 mediated mRNA export, and in the prevention of transcription-associated genome instability; ubiquitinated by Nedd4-like E3-ligase, Rsp5p; human ortholog DSS1, a BRCA1 binding protein implicated in cancer, complements the yeast null; drives trinucleotide repeat expansion; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YDR364C
symbol: CDC40
gene_biotype: protein_coding
description:
  Pre-mRNA-processing factor 17; Pre-mRNA splicing factor; important for catalytic step II of pre-mRNA splicing and plays a role in cell cycle progression, particularly at the G1/S phase transition; required for DNA synthesis during mitosis and meiosis; has WD repeats; thermosensitivity of the cdc40 null mutant is functionally complemented by a chimeric construct containing the N-terminal 156 amino acids of yeast Cdc40p fused to the C-terminal two thirds (297 amino acids) of human CDC40.


ensembl_gene_id: YDR365C
symbol: ESF1
gene_biotype: protein_coding
description:
  Pre-rRNA-processing protein ESF1; Nucleolar protein involved in pre-rRNA processing; depletion causes severely decreased 18S rRNA levels.


ensembl_gene_id: YDR367W
symbol: KEI1
gene_biotype: protein_coding
description:
  Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene.


ensembl_gene_id: YDR368W
symbol: YPR1
gene_biotype: protein_coding
description:
  Putative reductase 1; NADPH-dependent aldo-keto reductase; reduces multiple substrates including 2-methylbutyraldehyde and D,L-glyceraldehyde, expression is induced by osmotic and oxidative stress; functionally redundant with other aldo-keto reductases; protein abundance increases in response to DNA replication stress; YPR1 has a paralog, GCY1, that arose from the whole genome duplication; human homolog AKR1B1 can complement yeast null mutant.


ensembl_gene_id: YDR369C
symbol: XRS2
gene_biotype: protein_coding
description:
  Protein required for DNA repair; component of the Mre11 complex, which is involved in double strand breaks, meiotic recombination, telomere maintenance, and checkpoint signaling.


ensembl_gene_id: YDR370C
symbol: DXO1
gene_biotype: protein_coding
description:
  Decapping and exoribonuclease protein 1; mRNA 5'-end-capping quality-control protein; has distributive, 5'-3' exoRNase activity; similar to Rai1p;; Belongs to the DXO/Dom3Z family.


ensembl_gene_id: YDR371C-A
symbol: YDR371C-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YDR371C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the uncharacterized gene CTS2/YDR371W; identified by expression profiling and mass spectrometry.


ensembl_gene_id: YDR372C
symbol: VPS74
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 74; Golgi phosphatidylinositol-4-kinase effector and PtdIns4P sensor; interacts with the cytosolic domains of cis and medial glycosyltransferases, and in the PtdIns4P-bound state mediates the targeting of these enzymes to the Golgi; interacts with the catalytic domain of Sac1p, the major cellular PtdIns4P phosphatase, to direct dephosphosphorylation of the Golgi pool of PtdIns4P; tetramerization required for function; ortholog of human GOLPH3/GPP34/GMx33; Belongs to the GOLPH3/VPS74 family.


ensembl_gene_id: YDR373W
symbol: FRQ1
gene_biotype: protein_coding
description:
  N-myristoylated calcium-binding protein; may have a role in intracellular signaling through its regulation of the phosphatidylinositol 4-kinase Pik1p; member of the recoverin/frequenin branch of the EF-hand superfamily; human NCS1 functionally complements the heat sensitivity of a frq1 ts mutant.


ensembl_gene_id: YDR374C
symbol: PHO92
gene_biotype: protein_coding
description:
  Methylated RNA-binding protein 1; Posttranscriptional regulator of phosphate metabolism; facilitates PHO4 mRNA degradation by interacting with Pop2p; regulates PHO4 mRNA stability by binding to PHO4's 3'UTR in a phosphate-dependent manner; contains highly conserved YTH (YT521-B Homology) domain that exhibits RNA-binding activity; human homolog YTHDF2 can complement yeast null mutant.


ensembl_gene_id: YDR374W-A
symbol: WIP1
gene_biotype: protein_coding
description:
  Inner kinetochore subunit WIP1; Kinetochore localized protein of unknown function; interacts with Cnn1p (CENP-T); orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-W and fission yeast new1.


ensembl_gene_id: YDR375C
symbol: BCS1
gene_biotype: protein_coding
description:
  Mitochondrial chaperone BCS1; Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane and delivers it to an assembly intermediate of respiratory Complex III; also required for assembly of the Qcr10p subunit; mutation is functionally complemented by human homolog BCS1L, linked to neonatal diseases.


ensembl_gene_id: YDR376W
symbol: ARH1
gene_biotype: protein_coding
description:
  Probable NADPH:adrenodoxin oxidoreductase, mitochondrial; Oxidoreductase of the mitochondrial inner membrane; involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability; Belongs to the ferredoxin--NADP reductase type 1 family.


ensembl_gene_id: YDR377W
symbol: ATP17
gene_biotype: protein_coding
description:
  Subunit f of the F0 sector of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis.


ensembl_gene_id: YDR378C
symbol: LSM6
gene_biotype: protein_coding
description:
  U6 snRNA-associated Sm-like protein LSm6; Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.


ensembl_gene_id: YDR379C-A
symbol: SDH6
gene_biotype: protein_coding
description:
  Mitochondrial protein involved in assembly of succinate dehydrogenase; has a role in maturation of the Sdh2p subunit; member of the LYR protein family; mutations in human ortholog SDHAF1 are associated with infantile leukoencephalopathy.


ensembl_gene_id: YDR379W
symbol: RGA2
gene_biotype: protein_coding
description:
  GTPase-activating protein for polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; regulated by Pho85p and Cdc28p; RGA2 has a paralog, RGA1, that arose from the whole genome duplication.


ensembl_gene_id: YDR380W
symbol: ARO10
gene_biotype: protein_coding
description:
  Transaminated amino acid decarboxylase; Phenylpyruvate decarboxylase; catalyzes decarboxylation of phenylpyruvate to phenylacetaldehyde, which is the first specific step in the Ehrlich pathway; involved in protein N-terminal Met and Ala catabolism.


ensembl_gene_id: YDR381W
symbol: YRA1
gene_biotype: protein_coding
description:
  Nuclear polyadenylated RNA-binding protein; required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p; interacts with DBP2; inhibits the helicase activity of Dbp2; functionally redundant with Yra2p, another REF family member.


ensembl_gene_id: YDR382W
symbol: RPP2B
gene_biotype: protein_coding
description:
  60S acidic ribosomal protein P2-beta; Ribosomal protein P2 beta; a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; free (non-ribosomal) P2 stimulates the phosphorylation of the eIF2 alpha subunit (Sui2p) by Gcn2p; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm.


ensembl_gene_id: YDR383C
symbol: NKP1
gene_biotype: protein_coding
description:
  Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein fta4; Belongs to the NKP1 family.


ensembl_gene_id: YDR384C
symbol: ATO3
gene_biotype: protein_coding
description:
  Ammonia transport outward protein 3; Plasma membrane protein, putative ammonium transporter; regulation pattern suggests a possible role in export of ammonia from the cell; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family of putative transporters.


ensembl_gene_id: YDR385W
symbol: EFT2
gene_biotype: protein_coding
description:
  Elongation factor 2 (EF-2), also encoded by EFT1; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT2 has a paralog, EFT1, that arose from the whole genome duplication.


ensembl_gene_id: YDR386W
symbol: MUS81
gene_biotype: protein_coding
description:
  Subunit of structure-specific Mms4p-Mus81p endonuclease; cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; promotes template switching during break-induced replication (BIR), causing non-reciprocal translocations (NRTs); helix-hairpin-helix protein; phosphorylation of non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates function of Mms4p-Mus81p; Belongs to the XPF family.


ensembl_gene_id: YDR387C
symbol: CIN10
gene_biotype: protein_coding
description:
  Probable metabolite transport protein YDR387C; Putative transporter; member of the sugar porter family; non-essential gene; overexpression results in elevated colony sectoring, an indicator of chromosomal instability.


ensembl_gene_id: YDR388W
symbol: RVS167
gene_biotype: protein_coding
description:
  Reduced viability upon starvation protein 167; Calmodulin-binding actin-associated protein; roles in endocytic membrane tabulation and constriction, and exocytosis; N-BAR domain protein that interacts with Rvs161p to regulate actin cytoskeleton, endocytosis, and viability following starvation or osmotic stress; recruited to bud tips by Gyl1p and Gyp5p during polarized growth; homolog of mammalian amphiphysin.


ensembl_gene_id: YDR389W
symbol: SAC7
gene_biotype: protein_coding
description:
  GTPase-activating protein SAC7; GTPase activating protein (GAP) for Rho1p; regulator of a Tor2p-mediated, Rho1p GTPase switch that controls organization of the actin cytoskeleton; negative regulator of the RHO1-PKC1-MAPK cell integrity (CWI) and membrane fluidity homeostasis signaling pathways; potential Cdc28p substrate; SAC7 has a paralog, BAG7, that arose from the whole genome duplication.


ensembl_gene_id: YDR390C
symbol: UBA2
gene_biotype: protein_coding
description:
  Ubiquitin-activating enzyme E1-like; Subunit of heterodimeric nuclear SUMO activating enzyme E1 with Aos1p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability.


ensembl_gene_id: YDR391C
symbol: YDR391C
gene_biotype: protein_coding
description:
  Uncharacterized protein YDR391C; Putative protein of unknown function; possibly involved in zinc homeostasis; Bdf1p-dependent transcription induced by salt stress; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus.


ensembl_gene_id: YDR392W
symbol: SPT3
gene_biotype: protein_coding
description:
  Protein SPT3; Subunit of the SAGA and SAGA-like transcriptional regulatory complexes; interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters; relocalizes to the cytosol in response to hypoxia.


ensembl_gene_id: YDR393W
symbol: SHE9
gene_biotype: protein_coding
description:
  Sensitive to high expression protein 9, mitochondrial; Protein required for normal mitochondrial morphology; mitochondrial inner membrane protein; may be involved in fission of the inner membrane; forms a homo-oligomeric complex; Belongs to the SHE9 family.


ensembl_gene_id: YDR394W
symbol: RPT3
gene_biotype: protein_coding
description:
  ATPase of the 19S regulatory particle of the 26S proteasome; one of ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; substrate of N-acetyltransferase B.


ensembl_gene_id: YDR395W
symbol: SXM1
gene_biotype: protein_coding
description:
  Importin beta SMX1; Nuclear transport factor (karyopherin); involved in protein transport between the cytoplasm and nucleoplasm; similar to Nmd5p, Cse1p, Lph2p, and the human cellular apoptosis susceptibility protein, CAS1; Belongs to the importin beta family.


ensembl_gene_id: YDR396W
symbol: YDR396W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YDR396W; Dubious open reading frame unlikely to encode a functional protein; extensively overlaps essential NCB2 gene encoding the beta subunit of the NC2 dimeric histone-fold complex.


ensembl_gene_id: YDR397C
symbol: NCB2
gene_biotype: protein_coding
description:
  Subunit of a heterodimeric NC2 transcription regulator complex; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2beta; complex also includes Bur6p.


ensembl_gene_id: YDR398W
symbol: UTP5
gene_biotype: protein_coding
description:
  U3 small nucleolar RNA-associated protein 5; Subunit of U3-containing Small Subunit (SSU) processome complex; involved in production of 18S rRNA and assembly of small ribosomal subunit.


ensembl_gene_id: YDR399W
symbol: HPT1
gene_biotype: protein_coding
description:
  Dimeric hypoxanthine-guanine phosphoribosyltransferase; catalyzes the transfer of the phosphoribosyl portion of 5-phosphoribosyl-alpha-1-pyrophosphate to a purine base (either guanine or hypoxanthine) to form pyrophosphate and a purine nucleotide (either guanosine monophosphate or inosine monophosphate); mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome.


ensembl_gene_id: YDR400W
symbol: URH1
gene_biotype: protein_coding
description:
  Uridine nucleosidase (uridine-cytidine N-ribohydrolase); cleaves N-glycosidic bonds in nucleosides; involved in the pyrimidine salvage and nicotinamide riboside salvage pathways; Belongs to the IUNH family.


ensembl_gene_id: YDR401W
symbol: YDR401W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YDR401W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YDR402C
symbol: DIT2
gene_biotype: protein_coding
description:
  Cytochrome P450-DIT2; N-formyltyrosine oxidase; sporulation-specific microsomal enzyme involved in the production of N,N-bisformyl dityrosine required for spore wall maturation, homologous to cytochrome P-450s; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively.


ensembl_gene_id: YDR403W
symbol: DIT1
gene_biotype: protein_coding
description:
  Sporulation-specific enzyme required for spore wall maturation; involved in the production of a soluble LL-dityrosine-containing precursor of the spore wall; transcripts accumulate at the time of prospore enclosure.


ensembl_gene_id: YDR404C
symbol: RPB7
gene_biotype: protein_coding
description:
  RNA polymerase II subunit B16; forms dissociable heterodimer with Rpb4p; Rpb4/7 dissociates from RNAPII as Ser2 CTD phosphorylation increases; Rpb4/7 regulates cellular lifespan via mRNA decay process; involved in recruitment of 3'-end processing factors to transcribing RNA polymerase II complex, export of mRNA to cytoplasm under stress conditions; also involved in translation initiation.


ensembl_gene_id: YDR406W
symbol: PDR15
gene_biotype: protein_coding
description:
  ATP-dependent permease PDR15; Plasma membrane ATP binding cassette (ABC) transporter; multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element; PDR15 has a paralog, PDR5, that arose from the whole genome duplication.


ensembl_gene_id: YDR406W-A
symbol: YDR406W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YDR406W-A; Dubious open reading frame unlikely to encode a functional protein; identified by fungal homology and RT-PCR.


ensembl_gene_id: YDR407C
symbol: TRS120
gene_biotype: protein_coding
description:
  Trafficking protein particle complex II-specific subunit 120; Component of transport protein particle (TRAPP) complex II; TRAPPII is a multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p, regulating intra-Golgi and endosome-Golgi traffic; Belongs to the TRS120 family.


ensembl_gene_id: YDR408C
symbol: ADE8
gene_biotype: protein_coding
description:
  Phosphoribosylglycinamide formyltransferase; Phosphoribosyl-glycinamide transformylase; catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway.


ensembl_gene_id: YDR409W
symbol: SIZ1
gene_biotype: protein_coding
description:
  SUMO E3 ligase; promotes attachment of small ubiquitin-related modifier sumo (Smt3p) to primarily cytoplasmic proteins; regulates Rsp5p ubiquitin ligase activity and is in turn itself regulated by Rsp5p; required for sumoylation of septins and histone H3 variant Cse4p, a prerequisite for STUbL-mediated Ub-dependent degradation; localizes to the septin ring; acts as an adapter between E2, Ubc9p and substrates; tends to compensate for survival of DNA damage in absence of Nfi1p.


ensembl_gene_id: YDR410C
symbol: STE14
gene_biotype: protein_coding
description:
  Protein-S-isoprenylcysteine O-methyltransferase; Farnesyl cysteine-carboxyl methyltransferase; mediates the carboxyl methylation step during C-terminal CAAX motif processing of a-factor and RAS proteins in the endoplasmic reticulum, localizes to the ER membrane; Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.


ensembl_gene_id: YDR411C
symbol: DFM1
gene_biotype: protein_coding
description:
  DER1-like family member protein 1; Endoplasmic reticulum (ER) localized protein; involved in ER-associated protein degradation (ERAD), ER stress, and homeostasis; interacts with components of ERAD-L and ERAD-C and Cdc48p; derlin-like family member similar to Der1p; Belongs to the derlin family.


ensembl_gene_id: YDR412W
symbol: RRP17
gene_biotype: protein_coding
description:
  Ribosomal RNA-processing protein 17; Component of the pre-60S pre-ribosomal particle; required for cell viability under standard (aerobic) conditions but not under anaerobic conditions; exonuclease required for 5' end processing of pre-60S ribosomal RNA.


ensembl_gene_id: YDR413C
symbol: YDR413C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YDR413C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the essential uncharacterized ORF YDR412W that is implicated in rRNA processing.


ensembl_gene_id: YDR414C
symbol: ERD1
gene_biotype: protein_coding
description:
  Protein ERD1; Predicted membrane protein required for lumenal ER protein retention; mutants secrete the endogenous ER protein, BiP (Kar2p); Belongs to the ERD1 family.


ensembl_gene_id: YDR415C
symbol: YDR415C
gene_biotype: protein_coding
description:
  Probable aminopeptidase YDR415C; Putative aminopeptidase; SWAT-GFP fusion protein localizes to the endoplasmic reticulum and vacuole, while mCherry fusion localizes to the vacuole.


ensembl_gene_id: YDR416W
symbol: SYF1
gene_biotype: protein_coding
description:
  Pre-mRNA-splicing factor SYF1; Member of the NineTeen Complex (NTC); that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; null mutant has splicing defect and arrests in G2/M; relocalizes to the cytosol in response to hypoxia; homologs in human and C. elegans.


ensembl_gene_id: YDR417C
symbol: YDR417C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YDR417C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RPL12B/YDR418W.


ensembl_gene_id: YDR418W
symbol: RPL12B
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L12B; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12B has a paralog, RPL12A, that arose from the whole genome duplication.


ensembl_gene_id: YDR419W
symbol: RAD30
gene_biotype: protein_coding
description:
  DNA polymerase eta; involved in translesion synthesis during post-replication repair; catalyzes the synthesis of DNA opposite cyclobutane pyrimidine dimers and other lesions; involved in formation of post-replicative damage-induced genome-wide cohesion; may also have a role in protection against mitochondrial mutagenesis; mutations in human pol eta are responsible for XPV.


ensembl_gene_id: YDR420W
symbol: HKR1
gene_biotype: protein_coding
description:
  Signaling mucin HKR1; Mucin family member that functions as an osmosensor in the HOG pathway; large, highly glycosylated protein that functions redundantly with Msb2p in Sho1p-mediated osmostresss induction of the HOG signaling pathway; cytoplasmic domain interacts with Ahk1p a scaffold protein that prevents cross talk with the Kss1p MAPK of the filamentous growth pathway; mutant displays defects in beta-1,3 glucan synthesis and bud site selection; Belongs to the HKR1/MSB2 family.


ensembl_gene_id: YDR421W
symbol: ARO80
gene_biotype: protein_coding
description:
  Zinc finger transcriptional activator of the Zn2Cys6 family; activates transcription of aromatic amino acid catabolic genes in the presence of aromatic amino acids.


ensembl_gene_id: YDR422C
symbol: SIP1
gene_biotype: protein_coding
description:
  Alternate beta-subunit of the Snf1p kinase complex; may confer substrate specificity; vacuolar protein containing KIS (Kinase-Interacting Sequence) and ASC (Association with Snf1 kinase Complex) domains involved in protein interactions.


ensembl_gene_id: YDR423C
symbol: CAD1
gene_biotype: protein_coding
description:
  AP-1-like basic leucine zipper (bZIP) transcriptional activator; involved in stress responses, iron metabolism, and pleiotropic drug resistance; controls a set of genes involved in stabilizing proteins; binds consensus sequence TTACTAA; CAD1 has a paralog, YAP1, that arose from the whole genome duplication.


ensembl_gene_id: YDR424C
symbol: DYN2
gene_biotype: protein_coding
description:
  Cytoplasmic light chain dynein, microtubule motor protein; required for intracellular transport and cell division; involved in mitotic spindle positioning; forms complex with dynein intermediate chain Pac11p that promotes Dyn1p homodimerization, potentiates motor processivity; Dyn2p-Pac11p complex important for interaction of dynein motor complex with dynactin complex; acts as molecular glue to dimerize, stabilize Nup82-Nsp1-Nup159 complex module of cytoplasmic pore filaments.


ensembl_gene_id: YDR425W
symbol: SNX41
gene_biotype: protein_coding
description:
  Sorting nexin; involved in the retrieval of late-Golgi SNAREs from the post-Golgi endosome to the trans-Golgi network; interacts with Snx4p.


ensembl_gene_id: YDR426C
symbol: YDR426C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YDR426C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SNX41.


ensembl_gene_id: YDR427W
symbol: RPN9
gene_biotype: protein_coding
description:
  Non-ATPase regulatory subunit of the 26S proteasome; similar to putative proteasomal subunits in other species; null mutant is temperature sensitive and exhibits cell cycle and proteasome assembly defects; protein abundance increases in response to DNA replication stress; relocalizes to the cytosol in response to hypoxia.


ensembl_gene_id: YDR428C
symbol: BNA7
gene_biotype: protein_coding
description:
  Formylkynurenine formamidase; involved in the de novo biosynthesis of NAD from tryptophan via kynurenine.


ensembl_gene_id: YDR429C
symbol: TIF35
gene_biotype: protein_coding
description:
  eIF3g subunit of the eukaryotic translation initiation factor 3 (eIF3); subunit of the core complex of eIF3; is essential for translation; stimulates resumption of ribosomal scanning during translation reinitiation; eIF3 is also involved in programmed stop codon readthrough.


ensembl_gene_id: YDR430C
symbol: CYM1
gene_biotype: protein_coding
description:
  Mitochondrial presequence protease; Lysine-specific metalloprotease of the pitrilysin family; metalloprotease of the intermembrane space; degrades proteins and presequence peptides cleaved from imported proteins; required for normal mitochondrial morphology.


ensembl_gene_id: YDR431W
symbol: YDR431W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YDR431W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YDR432W
symbol: NPL3
gene_biotype: protein_coding
description:
  Nucleolar protein 3; RNA-binding protein; promotes elongation, regulates termination, and carries poly(A) mRNA from nucleus to cytoplasm; represses translation initiation by binding eIF4G; required for pre-mRNA splicing; interacts with E3 ubiquitin ligase Bre1p, linking histone ubiquitination to mRNA processing; may have role in telomere maintenance; dissociation from mRNAs promoted by Mtr10p; phosphorylated by Sky1p in cytoplasm; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YDR433W
symbol: YDR433W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YDR433W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YDR434W
symbol: GPI17
gene_biotype: protein_coding
description:
  GPI transamidase component GPI17; Transmembrane protein; subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-S homolog.


ensembl_gene_id: YDR435C
symbol: PPM1
gene_biotype: protein_coding
description:
  Carboxyl methyltransferase; methylates the C terminus of the protein phosphatase 2A catalytic subunit (Pph21p or Pph22p), which is important for complex formation with regulatory subunits; required for methionine to inhibit autophagy and promote growth.


ensembl_gene_id: YDR436W
symbol: PPZ2
gene_biotype: protein_coding
description:
  Serine/threonine-protein phosphatase PP-Z2; Serine/threonine protein phosphatase Z, isoform of Ppz1p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance; Belongs to the PPP phosphatase family. PP-Z subfamily.


ensembl_gene_id: YDR437W
symbol: GPI19
gene_biotype: protein_coding
description:
  Subunit of GPI-GlcNAc transferase involved in synthesis of GlcNAc-PI; N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI) is the first intermediate in glycosylphosphatidylinositol (GPI) anchor synthesis; shares similarity with mammalian PIG-P; Belongs to the GPI19 family.


ensembl_gene_id: YDR438W
symbol: THI74
gene_biotype: protein_coding
description:
  Mitochondrial transporter repressible by thiamine; THI74 has a paralog, YML018C, that arose from the whole genome duplication; shows sequence homology to human gene SLC35F3, a thiamine transporter implicated in hypertension.


ensembl_gene_id: YDR439W
symbol: LRS4
gene_biotype: protein_coding
description:
  Monopolin complex subunit LRS4; Nucleolar protein that forms a complex with Csm1p; and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation.


ensembl_gene_id: YDR440W
symbol: DOT1
gene_biotype: protein_coding
description:
  Histone-lysine N-methyltransferase, H3 lysine-79 specific; Nucleosomal histone H3-Lys79 methylase; methylation is required for telomeric silencing, meiotic checkpoint control, and DNA damage response.


ensembl_gene_id: YDR441C
symbol: APT2
gene_biotype: protein_coding
description:
  Potential adenine phosphoribosyltransferase; encodes a protein with similarity to adenine phosphoribosyltransferase, but artificially expressed protein exhibits no enzymatic activity; APT2 has a paralog, APT1, that arose from the whole genome duplication.


ensembl_gene_id: YDR442W
symbol: YDR442W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YDR442W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YDR443C
symbol: SSN2
gene_biotype: protein_coding
description:
  Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for stable association of Srb10p-Srb11p kinase; essential for transcriptional regulation.


ensembl_gene_id: YDR444W
symbol: YDR444W
gene_biotype: protein_coding
description:
  Putative lipase YDR444W; Putative hydrolase acting on ester bonds; Belongs to the putative lipase ROG1 family.


ensembl_gene_id: YDR445C
symbol: YDR445C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YDR445C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YDR446W
symbol: ECM11
gene_biotype: protein_coding
description:
  Meiosis-specific protein; component of the Synaptonemal Complex (SC) along with Gmc2p; required for efficient crossover formation and for the efficient loading of the SC transverse filament protein, Zip1p; is SUMOlytaed in a Gmc2p manner, and SUMOylation is required for its function in meiosis; GFP fusion protein is present in discrete clusters in the nucleus throughout mitosis; may be involved in maintaining chromatin structure.


ensembl_gene_id: YDR447C
symbol: RPS17B
gene_biotype: protein_coding
description:
  Ribosomal protein 51 (rp51) of the small (40s) subunit; homologous to mammalian ribosomal protein S17, no bacterial homolog; RPS17B has a paralog, RPS17A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YDR448W
symbol: ADA2
gene_biotype: protein_coding
description:
  Transcriptional adapter 2; Transcription coactivator; component of the ADA and SAGA transcriptional adaptor/HAT (histone acetyltransferase) complexes.


ensembl_gene_id: YDR449C
symbol: UTP6
gene_biotype: protein_coding
description:
  Nucleolar protein; component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA.


ensembl_gene_id: YDR450W
symbol: RPS18A
gene_biotype: protein_coding
description:
  Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18A has a paralog, RPS18B, that arose from the whole genome duplication; protein increases in abundance and relocalizes from cytoplasm to nuclear foci upon DNA replication stress.


ensembl_gene_id: YDR451C
symbol: YHP1
gene_biotype: protein_coding
description:
  Homeobox protein YHP1; Homeobox transcriptional repressor; binds Mcm1p and early cell cycle box (ECB) elements of cell cycle regulated genes, thereby restricting ECB-mediated transcription to the M/G1 interval; YHP1 has a paralog, YOX1, that arose from the whole genome duplication.


ensembl_gene_id: YDR452W
symbol: PPN1
gene_biotype: protein_coding
description:
  Endopolyphosphatase; Dual endo- and exopolyphosphatase with a role in phosphate metabolism; acts as both an endopolyphosphatase cleaving long chains of polyphosphate distributively to generate shorter polymer chains and as an exopolyphosphatase catalyzing the hydrolysis of terminal phosphate from polyphosphate; localizes to the vacuole, nucleus and cytosol; functions as a homodimer; relocalizes from vacuole to cytoplasm upon DNA replication stress.


ensembl_gene_id: YDR453C
symbol: TSA2
gene_biotype: protein_coding
description:
  Peroxiredoxin TSA2; Stress inducible cytoplasmic thioredoxin peroxidase; cooperates with Tsa1p in the removal of reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; deletion enhances the mutator phenotype of tsa1 mutants; protein abundance increases in response to DNA replication stress; TSA2 has a paralog, TSA1, that arose from the whole genome duplication; Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.


ensembl_gene_id: YDR454C
symbol: GUK1
gene_biotype: protein_coding
description:
  Guanylate kinase; converts GMP to GDP; required for growth and mannose outer chain elongation of cell wall N-linked glycoproteins.


ensembl_gene_id: YDR455C
symbol: YDR455C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YDR455C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W.


ensembl_gene_id: YDR456W
symbol: NHX1
gene_biotype: protein_coding
description:
  Endosomal/prevacuolar sodium/hydrogen exchanger; Na+/H+ and K+/H+ exchanger; required for intracellular sequestration of Na+ and K+; located in the vacuole and late endosome compartments; required for osmotolerance to acute hypertonic shock and for vacuolar fusion; ortholog of human NHE9, which is linked to autism; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.


ensembl_gene_id: YDR457W
symbol: TOM1
gene_biotype: protein_coding
description:
  E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus and may regulate transcriptional coactivators; involved in degradation of excess histones; interacts with Dia2p and is required for Dia2p degradation; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase; Belongs to the UPL family. TOM1/PTR1 subfamily.


ensembl_gene_id: YDR458C
symbol: HEH2
gene_biotype: protein_coding
description:
  Inner nuclear membrane (INM) protein; contains helix-extension-helix (HEH) motif, nuclear localization signal sequence; targeting to the INM requires the Srp1p-Kap95p karyopherins and the Ran cycle; HEH2 has a paralog, SRC1, that arose from the whole genome duplication.


ensembl_gene_id: YDR459C
symbol: PFA5
gene_biotype: protein_coding
description:
  Palmitoyltransferase with autoacylation activity; likely functions in pathway(s) outside Ras; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; Belongs to the DHHC palmitoyltransferase family. PFA5 subfamily.


ensembl_gene_id: YDR460W
symbol: TFB3
gene_biotype: protein_coding
description:
  Subunit of TFIIH and nucleotide excision repair factor 3 complexes; involved in transcription initiation, required for nucleotide excision repair; ring finger protein similar to mammalian CAK and TFIIH subunit.


ensembl_gene_id: YDR461W
symbol: MFA1
gene_biotype: protein_coding
description:
  Mating pheromone a-factor; made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA2.


ensembl_gene_id: YDR463W
symbol: STP1
gene_biotype: protein_coding
description:
  Transcription factor; contains a N-terminal regulatory motif (RI) that acts as a cytoplasmic retention determinant and as an Asi dependent degron in the nucleus; undergoes proteolytic processing by SPS (Ssy1p-Ptr3p-Ssy5p)-sensor component Ssy5p in response to extracellular amino acids; activates transcription of amino acid permease genes and may have a role in tRNA processing; STP1 has a paralog, STP2, that arose from the whole genome duplication.


ensembl_gene_id: YDR464C-A
symbol: YDR464C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YDR464C-A; Dubious open reading frame unlikely to encode a functional protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching.


ensembl_gene_id: YDR464W
symbol: SPP41
gene_biotype: protein_coding
description:
  Protein of unknown function; involved in negative regulation of expression of spliceosome components PRP4 and PRP3; relocalizes to the cytosol in response to hypoxia.


ensembl_gene_id: YDR465C
symbol: RMT2
gene_biotype: protein_coding
description:
  Arginine N5 methyltransferase; methylates ribosomal protein Rpl12 (L12) on Arg67; relative distribution to the nucleus increases upon DNA replication stress.


ensembl_gene_id: YDR466W
symbol: PKH3
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase PKH3; Protein kinase with similarity to mammalian PDK1 and yeast Pkh1p/Phk2p; yeast Pkh1p and Pkh2p are two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant.


ensembl_gene_id: YDR467C
symbol: YDR467C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YDR467C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YDR468C
symbol: TLG1
gene_biotype: protein_coding
description:
  Essential t-SNARE that mediates fusion of vesicles with the late Golgi; forms a complex with Tlg2p and Vti1p; mediates fusion of endosome-derived vesicles with the late Golgi; binds the docking complex VFT (Vps fifty-three) through interaction with Vps51p; Belongs to the syntaxin family.


ensembl_gene_id: YDR469W
symbol: SDC1
gene_biotype: protein_coding
description:
  COMPASS component SDC1; Subunit of the COMPASS (Set1C) complex; COMPASS methylates lysine 4 of histone H3 and is required in chromatin silencing at telomeres; contains a Dpy-30 domain that mediates interaction with Bre2p; similar to C. elegans and human DPY-30.


ensembl_gene_id: YDR470C
symbol: UGO1
gene_biotype: protein_coding
description:
  Outer membrane component of the mitochondrial fusion machinery; binds to Fzo1p and Mgm1p to link these two GTPases during mitochondrial fusion; involved in fusion of both the outer and inner membranes; facilitates dimerization of Fzo1p during fusion; import into the outer membrane is mediated by Tom70p and Mim1p; has similarity to carrier proteins but likely not a transporter; similar to human SLC25A46 implicated in optic atroprophy spectrum disorder.


ensembl_gene_id: YDR471W
symbol: RPL27B
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L27B; homologous to mammalian ribosomal protein L27, no bacterial homolog; RPL27B has a paralog, RPL27A, that arose from the whole genome duplication.


ensembl_gene_id: YDR472W
symbol: TRS31
gene_biotype: protein_coding
description:
  Core component of transport protein particle (TRAPP) complexes I-III; TRAPP complexes are related multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p, regulating ER-Golgi traffic (TRAPPI), intra-Golgi traffic (TRAPPII), endosome-Golgi traffic (TRAPPII and III) and autophagy (TRAPPIII).


ensembl_gene_id: YDR473C
symbol: PRP3
gene_biotype: protein_coding
description:
  U4/U6 small nuclear ribonucleoprotein PRP3; Splicing factor; component of the U4/U6-U5 snRNP complex.


ensembl_gene_id: YDR475C
symbol: JIP4
gene_biotype: protein_coding
description:
  Uncharacterized protein JIP4; Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence; JIP4 has a paralog, YOR019W, that arose from the whole genome duplication.


ensembl_gene_id: YDR476C
symbol: YDR476C
gene_biotype: protein_coding
description:
  Uncharacterized protein YDR476C; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR476C is not an essential gene.


ensembl_gene_id: YDR477W
symbol: SNF1
gene_biotype: protein_coding
description:
  AMP-activated S/T protein kinase; forms a complex with Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis; regulates nucleocytoplasmic shuttling of Hxk2p; regulates filamentous growth and acts as a non-canonical GEF, activating Arf3p during invasive growth; SUMOylation by Mms21p inhibits its function and targets Snf1p for destruction via the Slx5-Slx8 Ub ligase.


ensembl_gene_id: YDR478W
symbol: SNM1
gene_biotype: protein_coding
description:
  Ribonuclease MRP complex subunit; ribonuclease (RNase) MRP cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RNase MRP.


ensembl_gene_id: YDR479C
symbol: PEX29
gene_biotype: protein_coding
description:
  ER-resident protein involved in peroxisomal biogenesis; ER-localized protein that associates with peroxisomes; interacts with Pex30p and reticulons Rtn1p and Yop1p to regulate peroxisome biogenesis from the ER; role in peroxisomal-destined vesicular flow from the ER; regulates peroxisomal size, number and distribution; Pex28p and Pex29p may act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; forms ER foci upon DNA replication stress.


ensembl_gene_id: YDR480W
symbol: DIG2
gene_biotype: protein_coding
description:
  Down-regulator of invasive growth 2; MAP kinase-responsive inhibitor of the Ste12p transcription factor; involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p; DIG2 has a paralog, DIG1, that arose from the whole genome duplication.


ensembl_gene_id: YDR481C
symbol: PHO8
gene_biotype: protein_coding
description:
  Repressible vacuolar alkaline phosphatase; regulated by levels of Pi and by Pho4p, Pho9p, Pho80p, Pho81p and Pho85p; dephosphorylates phosphotyrosyl peptides; contributes to NAD+ metabolism by producing nicotinamide riboside from NMN.


ensembl_gene_id: YDR482C
symbol: CWC21
gene_biotype: protein_coding
description:
  Pre-mRNA-splicing factor CWC21; Protein involved in RNA splicing by the spliceosome; component of a complex containing Cef1p; interacts genetically with ISY1 and BUD13; may bind RNA; has similarity to S. pombe Cwf21p; Belongs to the CWC21 family.


ensembl_gene_id: YDR483W
symbol: KRE2
gene_biotype: protein_coding
description:
  Glycolipid 2-alpha-mannosyltransferase; Alpha1,2-mannosyltransferase of the Golgi; involved in protein mannosylation; KRE2 has a paralog, KTR6, that arose from the whole genome duplication.


ensembl_gene_id: YDR484W
symbol: VPS52
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 52; Component of the GARP (Golgi-associated retrograde protein) complex; GARP is required for the recycling of proteins from endosomes to the late Golgi, and for mitosis after DNA damage induced checkpoint arrest; involved in localization of actin and chitin; members of the GARP complex are Vps51p-Vps52p-Vps53p-Vps54p.


ensembl_gene_id: YDR485C
symbol: VPS72
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 72; Htz1p-binding component of the SWR1 complex; exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; may function as a lock that prevents removal of H2AZ from nucleosomes; required for vacuolar protein sorting.


ensembl_gene_id: YDR486C
symbol: VPS60
gene_biotype: protein_coding
description:
  Protein involved in late endosome to vacuole transport; cytoplasmic and vacuolar membrane protein; required for normal filament maturation during pseudohyphal growth; may function in targeting cargo proteins for degradation; interacts with Vta1p; Belongs to the SNF7 family.


ensembl_gene_id: YDR487C
symbol: RIB3
gene_biotype: protein_coding
description:
  3,4-dihydroxy-2-butanone-4-phosphate synthase (DHBP synthase); required for riboflavin biosynthesis from ribulose-5-phosphate, also has an unrelated function in mitochondrial respiration.


ensembl_gene_id: YDR488C
symbol: PAC11
gene_biotype: protein_coding
description:
  WD repeat-containing protein PAC11; Dynein intermediate chain, microtubule motor protein; required for intracellular transport and cell division; acts in cytoplasmic dynein pathway; forms complex with dynein light chain Dyn2p that promotes Dyn1p homodimerization and potentiates motor processivity; Dyn2p-Pac11p complex is also important for interaction of dynein motor complex with dynactin complex; forms cortical cytoplasmic microtubule capture site with Num1p; essential in the absence of CIN8.


ensembl_gene_id: YDR489W
symbol: SLD5
gene_biotype: protein_coding
description:
  Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p); complex is localized to DNA replication origins and implicated in assembly of the DNA replication machinery; Belongs to the GINS4/SLD5 family.


ensembl_gene_id: YDR490C
symbol: PKH1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase PKH1; Serine/threonine protein kinase; involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; contains a PH-like domain; redundant with Pkh2p; PKH1 has a paralog, PKH2, that arose from the whole genome duplication.


ensembl_gene_id: YDR491C
symbol: YDR491C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YDR491C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YDR492W
symbol: IZH1
gene_biotype: protein_coding
description:
  ADIPOR-like receptor IZH1; Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc; IZH1 has a paralog, IZH4, that arose from the whole genome duplication.


ensembl_gene_id: YDR493W
symbol: MZM1
gene_biotype: protein_coding
description:
  Mitochondrial zinc maintenance protein 1, mitochondrial; Protein required for assembly of the cytochrome bc(1) complex; acts as a chaperone for Rip1p and facilitates its insertion into the complex at a late stage of assembly; localized to the mitochondrial matrix; null mutant exhibits a respiratory growth defect and reduced mitochondrial zinc levels, which is characteristic of mutations affecting bc(1) complex assembly; member of the LYR protein family; human LYRM7 is a functional ortholog.


ensembl_gene_id: YDR494W
symbol: RSM28
gene_biotype: protein_coding
description:
  Mitochondrial ribosomal protein of the small subunit; genetic interactions suggest a possible role in promoting translation initiation.


ensembl_gene_id: YDR495C
symbol: VPS3
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 3; Component of CORVET membrane tethering complex; cytoplasmic protein required for the sorting and processing of soluble vacuolar proteins, acidification of the vacuolar lumen, and assembly of the vacuolar H+-ATPase.


ensembl_gene_id: YDR496C
symbol: PUF6
gene_biotype: protein_coding
description:
  Pumilio-homology domain protein; binds the 3' UTR of ASH1 mRNA and represses its translation, resulting in proper asymmetric localization of ASH1 mRNA; required at post-transcriptional step for efficient retrotransposition; absence results in decreased Ty1 Gag:GFP protein levels; co-sediments with the 60S ribosomal subunit and is required for its biogenesis; Belongs to the PUF6 family.


ensembl_gene_id: YDR497C
symbol: ITR1
gene_biotype: protein_coding
description:
  Myo-inositol transporter; member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p; relative distribution to the vacuole increases upon DNA replication stress; ITR1 has a paralog, ITR2, that arose from the whole genome duplication.


ensembl_gene_id: YDR498C
symbol: SEC20
gene_biotype: protein_coding
description:
  Membrane glycoprotein v-SNARE; involved in retrograde transport from the Golgi to the endoplasmic reticulum (ER); required for N- and O-glycosylation in the Golgi but not in the ER and for efficient nuclear fusion during mating; mediates Sey1p-independent homotypic ER fusion; interacts with the Dsl1p complex through Tip20p; Belongs to the SEC20 family.


ensembl_gene_id: YDR499W
symbol: LCD1
gene_biotype: protein_coding
description:
  Essential protein required for the DNA integrity checkpoint pathways; interacts physically with Mec1p; putative homolog of S. pombe Rad26 and human ATRIP; forms nuclear foci upon DNA replication stress.


ensembl_gene_id: YDR500C
symbol: RPL37B
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L37B; required for processing of 27SB pre-rRNA and formation of stable 66S assembly intermediates; protein abundance increases in response to DNA replication stress; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37B has a paralog, RPL37A, that arose from the whole genome duplication.


ensembl_gene_id: YDR501W
symbol: PLM2
gene_biotype: protein_coding
description:
  Protein PLM2; Putative transcription factor, contains Forkhead Associated domain; found associated with chromatin; target of SBF transcription factor; induced in response to DNA damaging agents and deletion of telomerase; PLM2 has a paralog, TOS4, that arose from the whole genome duplication; Belongs to the PLM2/TOS4 family.


ensembl_gene_id: YDR502C
symbol: SAM2
gene_biotype: protein_coding
description:
  S-adenosylmethionine synthase 2; S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; comparative analysis suggests that a mitochondrially targeted form may result from translation starting at a non-canonical codon upstream of the annotated start codon.


ensembl_gene_id: YDR503C
symbol: LPP1
gene_biotype: protein_coding
description:
  Lipid phosphate phosphatase; catalyzes Mg(2+)-independent dephosphorylation of phosphatidic acid (PA), lysophosphatidic acid, and diacylglycerol pyrophosphate; involved in control of the cellular levels of phosphatidylinositol and PA.


ensembl_gene_id: YDR504C
symbol: SPG3
gene_biotype: protein_coding
description:
  Stationary phase protein 3; Protein required for high temperature survival during stationary phase; not required for growth on nonfermentable carbon sources; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum.


ensembl_gene_id: YDR505C
symbol: PSP1
gene_biotype: protein_coding
description:
  Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication.


ensembl_gene_id: YDR506C
symbol: GMC1
gene_biotype: protein_coding
description:
  Putative multicopper oxidase GMC1; Protein involved in meiotic progression; mutants are delayed in meiotic nuclear division and are defective in synaptonemal complex assembly; possible membrane-localized protein; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively.


ensembl_gene_id: YDR507C
symbol: GIN4
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase GIN4; Protein kinase involved in bud growth and assembly of the septin ring; proposed to have kinase-dependent and kinase-independent activities; undergoes autophosphorylation; similar to Hsl1p; GIN4 has a paralog, KCC4, that arose from the whole genome duplication.


ensembl_gene_id: YDR508C
symbol: GNP1
gene_biotype: protein_coding
description:
  High-affinity glutamine permease; also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids; GNP1 has a paralog, AGP1, that arose from the whole genome duplication.


ensembl_gene_id: YDR509W
symbol: YDR509W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YDR509W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YDR510C-A
symbol: YDR510C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YDR510C-A; Dubious open reading frame unlikely to encode a functional protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching.


ensembl_gene_id: YDR510W
symbol: SMT3
gene_biotype: protein_coding
description:
  Ubiquitin-like protein of the SUMO family; conjugated to lysine residues of target proteins; associates with transcriptionally active genes; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics; human homolog SUMO1 can complement yeast null mutant.


ensembl_gene_id: YDR511W
symbol: SDH7
gene_biotype: protein_coding
description:
  Mitochondrial protein involved in assembly of succinate dehydrogenase; has a role in maturation of the Sdh2p subunit; localized to the mitochondrial intermembrane space; required for acetate utilization and gluconeogenesis; mutation in Drosophila ortholog SDHAF3 causes reduced succinate dehydrogenase activity and neuronal and muscular dysfunction; member of the LYR protein family.


ensembl_gene_id: YDR512C
symbol: EMI1
gene_biotype: protein_coding
description:
  Early meiotic induction protein 1; Non-essential protein of unknown function; required for transcriptional induction of the early meiotic-specific transcription factor IME1, also required for sporulation; contains twin cysteine-x9-cysteine motifs; deletion affects mitochondrial morphology.


ensembl_gene_id: YDR513W
symbol: GRX2
gene_biotype: protein_coding
description:
  Glutaredoxin-2; Cytoplasmic glutaredoxin; thioltransferase, glutathione-dependent disulfide oxidoreductase involved in maintaining redox state of target proteins, also exhibits glutathione peroxidase activity, expression induced in response to stress; GRX2 has two in-frame start codons resulting in a shorter isoform that is retained in the cytosol and a longer form translocated to the mitochondrial matrix; GRX2 has a paralog, GRX1, that arose from the whole genome duplication.


ensembl_gene_id: YDR514C
symbol: YDR514C
gene_biotype: protein_coding
description:
  Uncharacterized protein YDR514C; Protein of unknown function that localizes to mitochondria; overexpression affects endocytic protein trafficking; YDR514C has a paralog, GFD2, that arose from the whole genome duplication.


ensembl_gene_id: YDR515W
symbol: SLF1
gene_biotype: protein_coding
description:
  RNA binding protein that associates with polysomes; may be involved in regulating mRNA translation; involved in the copper-dependent mineralization of copper sulfide complexes on cell surface in cells cultured in copper salts; SLF1 has a paralog, SRO9, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YDR516C
symbol: EMI2
gene_biotype: protein_coding
description:
  Putative glucokinase-2; Non-essential protein of unknown function; required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expression regulated by glucose-repression transcription factors Mig1/2p; EMI2 has a paralog, GLK1, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress; Belongs to the hexokinase family.


ensembl_gene_id: YDR517W
symbol: GRH1
gene_biotype: protein_coding
description:
  GRASP65 homolog protein 1; Acetylated cis-Golgi protein, involved in ER to Golgi transport; homolog of human GRASP65; forms a complex with the coiled-coil protein Bug1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YDR518W
symbol: EUG1
gene_biotype: protein_coding
description:
  Protein disulfide-isomerase EUG1; Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER.


ensembl_gene_id: YDR519W
symbol: FPR2
gene_biotype: protein_coding
description:
  Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase); binds to the drugs FK506 and rapamycin; expression pattern suggests possible involvement in ER protein trafficking; relocalizes from nucleus to vacuole upon DNA replication stress; mutation is functionally complemented by human FKBP2.


ensembl_gene_id: YDR520C
symbol: URC2
gene_biotype: protein_coding
description:
  Uracil catabolism protein 2; Putative Zn(II)2Cys6 motif containing transcription factor; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; similar to S. kluyveri Urc2p involved in uracil catabolism.


ensembl_gene_id: YDR521W
symbol: YDR521W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YDR521W; Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol.


ensembl_gene_id: YDR522C
symbol: SPS2
gene_biotype: protein_coding
description:
  Protein expressed during sporulation; SPS2 has a paralog, SPS22, that arose from the whole genome duplication; redundant with Sps22p for organization of the beta-glucan layer of the spore wall; S. pombe ortholog is a spore wall component.


ensembl_gene_id: YDR523C
symbol: SPS1
gene_biotype: protein_coding
description:
  Sporulation-specific protein 1; Putative protein serine/threonine kinase; localizes to the nucleus and cytoplasm; required for efficient spore packaging, prospore membrane development and closure and localization of enzymes involved in spore wall synthesis; interacts with and required for Ssp1p phosphorylation and turnover; member of the GCKIII subfamily of STE20 kinases; multiply phosphorylated on S/T residues; interacts with 14-3-3 proteins, Bmh1p and Bmh2p; expressed at the end of meiosis.


ensembl_gene_id: YDR524C
symbol: AGE1
gene_biotype: protein_coding
description:
  ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector; involved in the secretory and endocytic pathways; contains C2C2H2 cysteine/histidine motif.


ensembl_gene_id: YDR524C-A
symbol: YDR524C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YDR524C-A; Dubious open reading frame unlikely to encode a functional protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching.


ensembl_gene_id: YDR524C-B
symbol: YDR524C-B
gene_biotype: protein_coding
description:
  Uncharacterized protein YDR524C-B; Putative protein of unknown function; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum; YDR524C-B has a paralog, YCL048W-A, that arose from the whole genome duplication.


ensembl_gene_id: YDR524W-C
symbol: YDR524W-C
gene_biotype: protein_coding
description:
  Uncharacterized protein YDR524W-C; Putative protein of unknown function; small ORF identified by SAGE; deletion strains are moderately sensitive to the radiomimetic drug bleomycin.


ensembl_gene_id: YDR525W
symbol: API2
gene_biotype: protein_coding
description:
  Uncharacterized protein API2; Putative protein of unknown function; conserved among S. cerevisiae strains; not conserved in closely related Saccharomyces species; 26% of ORF overlaps the dubious ORF YDR524C-A; insertion mutation in a cdc34-2 mutant background causes altered bud morphology.


ensembl_gene_id: YDR525W-A
symbol: SNA2
gene_biotype: protein_coding
description:
  Protein of unknown function; has similarity to Pmp3p, which is involved in cation transport; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; Belongs to the UPF0057 (PMP3) family.


ensembl_gene_id: YDR526C
symbol: YDR526C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YDR526C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YDR527W
symbol: RBA50
gene_biotype: protein_coding
description:
  Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1; Belongs to the RPAP1 family.


ensembl_gene_id: YDR528W
symbol: HLR1
gene_biotype: protein_coding
description:
  Protein involved in regulation of cell wall composition and integrity; also involved in cell wall response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; HLR1 has a paralog, LRE1, that arose from the whole genome duplication.


ensembl_gene_id: YDR529C
symbol: QCR7
gene_biotype: protein_coding
description:
  Subunit 7 of ubiquinol cytochrome-c reductase (Complex III); Complex III is a component of the mitochondrial inner membrane electron transport chain; oriented facing the mitochondrial matrix; N-terminus appears to play a role in complex assembly; Belongs to the UQCRB/QCR7 family.


ensembl_gene_id: YDR530C
symbol: APA2
gene_biotype: protein_coding
description:
  Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase II; AP4A phosphorylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; APA2 has a paralog, APA1, that arose from the whole genome duplication.


ensembl_gene_id: YDR531W
symbol: CAB1
gene_biotype: protein_coding
description:
  Pantothenate kinase, ATP:D-pantothenate 4'-phosphotransferase; catalyzes the first committed step in the universal biosynthetic pathway for synthesis of coenzyme A (CoA); transcriptionally regulated by Upc2p via a sterol response element.


ensembl_gene_id: YDR532C
symbol: KRE28
gene_biotype: protein_coding
description:
  Spindle pole body component KRE28; Subunit of a kinetochore-microtubule binding complex; complex bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components; complex also includes Spc105p; modified by sumoylation.


ensembl_gene_id: YDR533C
symbol: HSP31
gene_biotype: protein_coding
description:
  Glutathione-independent glyoxalase HSP31; Methylglyoxalase that converts methylglyoxal to D-lactate; involved in oxidative stress resistance, diauxic shift, and stationary phase survival; has similarity to E. coli Hsp31 and C. albicans Glx3p; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease and cancer; exists as a dimer and contains a putative metal-binding site; protein abundance increases in response to DNA replication stress; Belongs to the peptidase C56 family. HSP31-like subfamily.


ensembl_gene_id: YDR534C
symbol: FIT1
gene_biotype: protein_coding
description:
  Facilitator of iron transport 1; Mannoprotein that is incorporated into the cell wall; incorporated via a glycosylphosphatidylinositol (GPI) anchor; involved in the retention of siderophore-iron in the cell wall.


ensembl_gene_id: YDR535C
symbol: YDR535C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YDR535C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; YDR535C is not an essential gene.


ensembl_gene_id: YDR536W
symbol: STL1
gene_biotype: protein_coding
description:
  Sugar transporter STL1; Glycerol proton symporter of the plasma membrane; subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock.


ensembl_gene_id: YDR537C
symbol: YDR537C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YDR537C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps verified ORF PAD1/YDR538W.


ensembl_gene_id: YDR538W
symbol: PAD1
gene_biotype: protein_coding
description:
  Flavin prenyltransferase PAD1, mitochondrial; Phenylacrylic acid decarboxylase; confers resistance to cinnamic acid, decarboxylates aromatic carboxylic acids to the corresponding vinyl derivatives; also has mRNA binding activity; homolog of E. coli UbiX; co-overproduction of Pad1p and Fdc1p greatly increases cinnamic acid decarboxylase activity.


ensembl_gene_id: YDR539W
symbol: FDC1
gene_biotype: protein_coding
description:
  Ferulic acid decarboxylase, also active on p-coumaric acid; essential for decarboxylation of aromatic carboxylic acids to corresponding vinyl derivatives; co-overproduction of Pad1p and Fdc1p greatly increases cinnamic acid decarboxylase activity; structure implicates Glu285 as the general base in the nonoxidative decarboxylation reaction catalyzed by Fdc1p; homolog of E. coli UbiD; GFP-fusion protein localizes to cytoplasm.


ensembl_gene_id: YDR540C
symbol: IRC4
gene_biotype: protein_coding
description:
  Uncharacterized protein IRC4; Protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus.


ensembl_gene_id: YDR541C
symbol: YDR541C
gene_biotype: protein_coding
description:
  Putative uncharacterized oxidoreductase YDR541C; Aldehyde reductase; substrates include both aromatic and aliphatic aldehydes; uses NADPH as cofactor; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively; Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.


ensembl_gene_id: YDR542W
symbol: PAU10
gene_biotype: protein_coding
description:
  Seripauperin-10; Protein of unknown function; SWAT-GFP fusion protein localizes to the endoplasmic reticulum and vacuole, while mCherry fusion localizes to the vacuole; member of the seripauperin multigene family encoded mainly in subtelomeric regions; Belongs to the SRP1/TIP1 family. Seripauperin subfamily.


ensembl_gene_id: YDR543C
symbol: YDR543C
gene_biotype: protein_coding
description:
  Putative UPF0320 protein YDR543C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YDR544C
symbol: YDR544C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YDR544C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YDR545C-A
symbol: YDR545C-A
gene_biotype: protein_coding
description:
  Putative UPF0479 protein YDR545C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF YRF1-1/YDR545W; Belongs to the UPF0479 family.


ensembl_gene_id: YDR545W
symbol: YRF1-1
gene_biotype: protein_coding
description:
  Y' element ATP-dependent helicase protein 1 copy 1; Helicase encoded by the Y' element of subtelomeric regions; highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p.


ensembl_gene_id: YEL001C
symbol: IRC22
gene_biotype: protein_coding
description:
  Increased recombination centers protein 22; Protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci; Belongs to the IRC22 family.


ensembl_gene_id: YEL002C
symbol: WBP1
gene_biotype: protein_coding
description:
  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1; Beta subunit of the oligosaccharyl transferase glycoprotein complex; required for N-linked glycosylation of proteins in the endoplasmic reticulum; human homolog DDOST can complement yeast growth defect during down-regulation of yeast gene.


ensembl_gene_id: YEL003W
symbol: GIM4
gene_biotype: protein_coding
description:
  Prefoldin subunit 2; Subunit of the heterohexameric cochaperone prefoldin complex; complex binds specifically to cytosolic chaperonin and transfers target proteins to it.


ensembl_gene_id: YEL004W
symbol: YEA4
gene_biotype: protein_coding
description:
  UDP-N-acetylglucosamine transporter YEA4; Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter; required for cell wall chitin synthesis; localized to the ER; Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.


ensembl_gene_id: YEL005C
symbol: VAB2
gene_biotype: protein_coding
description:
  Subunit of the BLOC-1 complex involved in endosomal maturation; interacts with Vps21p-GFP; has potential role in vacuolar function, as suggested by its ability to bind Vac8p; likely member of; Vab2p-GFP-fusion localizes to cytoplasm in punctate pattern.


ensembl_gene_id: YEL006W
symbol: YEA6
gene_biotype: protein_coding
description:
  Mitochondrial nicotinamide adenine dinucleotide transporter 2; Putative mitochondrial NAD+ transporter; member of the mitochondrial carrier subfamily (see also YIA6); has putative human ortholog; YEA6 has a paralog, YIA6, that arose from the whole genome duplication.


ensembl_gene_id: YEL007W
symbol: MIT1
gene_biotype: protein_coding
description:
  Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1.


ensembl_gene_id: YEL008C-A
symbol: YEL008C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YEL008C-A; Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching.


ensembl_gene_id: YEL008W
symbol: YEL008W
gene_biotype: protein_coding
description:
  Uncharacterized protein YEL008W; Putative protein of unknown function; conserved among S. cerevisiae strains; YEL008W is not an essential gene; predicted to be involved in metabolism.


ensembl_gene_id: YEL009C
symbol: GCN4
gene_biotype: protein_coding
description:
  General control protein GCN4; bZIP transcriptional activator of amino acid biosynthetic genes;  activator responds to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels; Belongs to the bZIP family. GCN4 subfamily.


ensembl_gene_id: YEL009C-A
symbol: YEL009C-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YEL009C-A; Putative protein of unknown function; conserved among S. cerevisiae strains; overlaps ORF YEL010W.


ensembl_gene_id: YEL010W
symbol: YEL010W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YEL010W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YEL011W
symbol: GLC3
gene_biotype: protein_coding
description:
  Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress; glycogen accumulation defect of the null mutant is functionally complemented by human GBE1, which is associated with glycogen storage disease; Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.


ensembl_gene_id: YEL012W
symbol: UBC8
gene_biotype: protein_coding
description:
  Ubiquitin-conjugating enzyme that regulates gluconeogenesis; negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro.


ensembl_gene_id: YEL013W
symbol: VAC8
gene_biotype: protein_coding
description:
  Vacuolar protein 8; Phosphorylated and palmitoylated vacuolar membrane protein; interacts with Atg13p, required for the cytoplasm-to-vacuole targeting (Cvt) pathway; interacts with Nvj1p to form nucleus-vacuole junctions.


ensembl_gene_id: YEL014C
symbol: YEL014C
gene_biotype: protein_coding
description:
  Uncharacterized protein YEL014C; Putative protein of unknown function; conserved among S. cerevisiae strains.


ensembl_gene_id: YEL015W
symbol: EDC3
gene_biotype: protein_coding
description:
  Enhancer of mRNA-decapping protein 3; Non-essential conserved protein with a role in mRNA decapping; specifically affects the function of the decapping enzyme Dcp1p; mediates decay of the RPS28B mRNA via binding to both Rps28Bp (or Rps28Ap) and the RPS28B mRNA; mediates decay of the YRA1 mRNA by a different, translation-independent mechanism; localizes to cytoplasmic mRNA processing bodies; forms cytoplasmic foci upon DNA replication stress.


ensembl_gene_id: YEL016C
symbol: NPP2
gene_biotype: protein_coding
description:
  Ectonucleotide pyrophosphatase/phosphodiesterase 2; Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp1p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; involved in spore wall assembly; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum; NPP2 has a paralog, NPP1, that arose from the whole genome duplication; npp1 npp2 double mutant exhibits reduced dityrosine fluorescence relative to single mutants.


ensembl_gene_id: YEL017C-A
symbol: PMP2
gene_biotype: protein_coding
description:
  Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p); regulates plasma membrane H(+)-ATPase activity; protein abundance increases in response to DNA replication stress; PMP2 has a paralog, PMP1, that arose from the whole genome duplication.


ensembl_gene_id: YEL017W
symbol: GTT3
gene_biotype: protein_coding
description:
  Glutathione transferase 3; Protein of unknown function may be involved in glutathione metabolism; function suggested by computational analysis of large-scale protein-protein interaction data; N- and C-terminal fusion proteins localize to the cell periphery.


ensembl_gene_id: YEL018C-A
symbol: YEL018C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized membrane protein YEL018C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF EAF5/YEL018W.


ensembl_gene_id: YEL018W
symbol: EAF5
gene_biotype: protein_coding
description:
  Chromatin modification-related protein EAF5; Non-essential subunit of the NuA4 acetyltransferase complex; Esa1p-associated factor; relocalizes to the cytosol in response to hypoxia.


ensembl_gene_id: YEL019C
symbol: MMS21
gene_biotype: protein_coding
description:
  Highly conserved SUMO E3 ligase subunit of SMC5-SMC6 complex; required for anchoring dsDNA breaks to the nuclear periphery; SMC5-SMC6 plays a key role in removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; required for efficient sister chromatid cohesion; mutants are sensitive to MMS, show increased spontaneous mutation and mitotic recombination; SUMOylates and inhibits Snf1p function; supports nucleolar function; Belongs to the NSE2 family.


ensembl_gene_id: YEL020C
symbol: PXP1
gene_biotype: protein_coding
description:
  Putative 2-hydroxyacyl-CoA lyase; Peroxisomal matrix protein; well-conserved in fungi; contains tripartite homology domain of thiamine pyrophosphate (TPP) enzymes; targeted to peroxisomes by Pex5p; contains low sequence identity with Pdc1p; mRNA identified as translated by ribosome profiling data.


ensembl_gene_id: YEL020C-B
symbol: YEL020C-B
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YEL020C-B; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified gene YEL020W-A; identified by fungal homology and RT-PCR.


ensembl_gene_id: YEL020W-A
symbol: TIM9
gene_biotype: protein_coding
description:
  Mitochondrial import inner membrane translocase subunit TIM9; Essential protein of the mitochondrial intermembrane space; forms a complex with Tim10p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner membrane.


ensembl_gene_id: YEL021W
symbol: URA3
gene_biotype: protein_coding
description:
  Orotidine-5'-phosphate (OMP) decarboxylase; catalyzes the sixth enzymatic step in the de novo biosynthesis of pyrimidines, converting OMP into uridine monophosphate (UMP); converts 5-FOA into 5-fluorouracil, a toxic compound.


ensembl_gene_id: YEL022W
symbol: GEA2
gene_biotype: protein_coding
description:
  Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA2 has a paralog, GEA1, that arose from the whole genome duplication.


ensembl_gene_id: YEL023C
symbol: YEL023C
gene_biotype: protein_coding
description:
  Uncharacterized protein YEL023C; Putative protein of unknown function; expression is increased greatly during sporulation; YEL023C is not an essential gene.


ensembl_gene_id: YEL024W
symbol: RIP1
gene_biotype: protein_coding
description:
  Ubiquinol-cytochrome-c reductase; a Rieske iron-sulfur protein of the mitochondrial cytochrome bc1 complex; transfers electrons from ubiquinol to cytochrome c1 during respiration; during import, Rip1p is first imported into the mitochondrial matrix where it is processed, acquires its Fe-S cluster, and is folded, then is translocated into the inner membrane by the action of a homo-oligomer of Bcs1p, and finally is delivered by Bcs1p to Complex III for assembly.


ensembl_gene_id: YEL025C
symbol: YEL025C
gene_biotype: protein_coding
description:
  Uncharacterized protein YEL025C; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus.


ensembl_gene_id: YEL026W
symbol: SNU13
gene_biotype: protein_coding
description:
  13 kDa ribonucleoprotein-associated protein; RNA binding protein; part of U3 snoRNP involved in rRNA processing, part of U4/U6-U5 tri-snRNP involved in mRNA splicing, similar to human 15.5K protein; Belongs to the eukaryotic ribosomal protein eL8 family.


ensembl_gene_id: YEL027W
symbol: VMA3
gene_biotype: protein_coding
description:
  V-type proton ATPase subunit c; Proteolipid subunit c of the V0 domain of vacuolar H(+)-ATPase; dicyclohexylcarbodiimide binding subunit; required for vacuolar acidification and important for copper and iron metal ion homeostasis; Belongs to the V-ATPase proteolipid subunit family.


ensembl_gene_id: YEL028W
symbol: YEL028W
gene_biotype: protein_coding
description:
  Uncharacterized protein YEL028W; Putative protein of unknown function; conserved among S. cerevisiae strains; YEL028C is not an essential gene.


ensembl_gene_id: YEL029C
symbol: BUD16
gene_biotype: protein_coding
description:
  Putative pyridoxal kinase; a key enzyme involved in pyridoxal 5'-phosphate synthesis, the active form of vitamin B6; required for genome integrity; involved in bud-site selection; similarity to yeast BUD17 and human pyridoxal kinase (PDXK).


ensembl_gene_id: YEL030C-A
symbol: YEL030C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YEL030C-A; Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching.


ensembl_gene_id: YEL030W
symbol: ECM10
gene_biotype: protein_coding
description:
  Heat shock protein of the Hsp70 family; localized in mitochondrial nucleoids, plays a role in protein translocation, interacts with Mge1p in an ATP-dependent manner; overexpression induces extensive mitochondrial DNA aggregations; ECM10 has a paralog, SSC1, that arose from the whole genome duplication.


ensembl_gene_id: YEL031W
symbol: SPF1
gene_biotype: protein_coding
description:
  Manganese-transporting ATPase 1; P-type ATPase, ion transporter of the ER membrane; required to maintain normal lipid composition of intracellular compartments and proper targeting of mitochondrial outer membrane tail-anchored proteins; involved in ER function and Ca2+ homeostasis; required for regulating Hmg2p degradation; confers sensitivity to a killer toxin (SMKT) produced by Pichia farinosa KK1.


ensembl_gene_id: YEL032C-A
symbol: YEL032C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YEL032C-A; Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching.


ensembl_gene_id: YEL032W
symbol: MCM3
gene_biotype: protein_coding
description:
  DNA replication licensing factor MCM3; Protein involved in DNA replication; component of the Mcm2-7 hexameric helicase complex that binds chromatin as a part of the pre-replicative complex.


ensembl_gene_id: YEL033W
symbol: MTC7
gene_biotype: protein_coding
description:
  Maintenance of telomere capping protein 7; Protein of unknown function; predicted metabolic role based on network analysis derived from ChIP experiments, a large-scale deletion study and localization of transcription factor binding sites; null mutant is sensitive to temperature oscillation in a cdc13-1 mutant.


ensembl_gene_id: YEL034C-A
symbol: YEL034C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YEL034C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps HYP2/YEL034W, a verified gene that encodes eiF-5A.


ensembl_gene_id: YEL034W
symbol: HYP2
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 5A-1; Translation elongation factor eIF-5A; required for translation of proteins containing polyproline stretches, including Bni1p, and this leads to a requirement for mating projection formation; structural homolog of bacterial EF-P; undergoes an essential hypusination modification; HYP2 has a paralog, ANB1, that arose from the whole genome duplication; human EIF5A complements the inviability of the yeast hyp2 anb1 double null mutant.


ensembl_gene_id: YEL035C
symbol: UTR5
gene_biotype: protein_coding
description:
  Protein of unknown function; transcription may be regulated by Gcr1p; essential for growth under standard (aerobic) conditions but not under anaerobic conditions.


ensembl_gene_id: YEL036C
symbol: ANP1
gene_biotype: protein_coding
description:
  Subunit of the alpha-1,6 mannosyltransferase complex; type II membrane protein; has a role in retention of glycosyltransferases in the Golgi; involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol.


ensembl_gene_id: YEL037C
symbol: RAD23
gene_biotype: protein_coding
description:
  UV excision repair protein RAD23; Protein with ubiquitin-like N terminus; subunit of Nuclear Excision Repair Factor 2 (NEF2) with Rad4p that binds damaged DNA; enhances protein deglycosylation activity of Png1p; also involved, with Rad4p, in ubiquitylated protein turnover; Rad4p-Rad23p heterodimer binds to promoters of DNA damage response genes to repress their transcription in the absence of DNA damage.


ensembl_gene_id: YEL038W
symbol: UTR4
gene_biotype: protein_coding
description:
  Enolase-phosphatase E1; Protein with sequence similarity to acireductone synthases; involved in methionine salvage; found in both the cytoplasm and nucleus; Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.


ensembl_gene_id: YEL039C
symbol: CYC7
gene_biotype: protein_coding
description:
  Cytochrome c isoform 2, expressed under hypoxic conditions; also known as iso-2-cytochrome c; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; protein abundance increases in response to DNA replication stress; CYC7 has a paralog, CYC1, that arose from the whole genome duplication.


ensembl_gene_id: YEL040W
symbol: UTR2
gene_biotype: protein_coding
description:
  Probable glycosidase CRH2; Chitin transglycosylase; functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar to and functionally redundant with Crh1; glycosylphosphatidylinositol (GPI)-anchored protein localized to bud neck.


ensembl_gene_id: YEL041W
symbol: YEF1
gene_biotype: protein_coding
description:
  ATP-NADH kinase; phosphorylates both NAD and NADH; homooctameric structure consisting of 60-kDa subunits; similar to Pos5p; overexpression complements certain pos5 phenotypes; YEF1 has a paralog, UTR1, that arose from the whole genome duplication.


ensembl_gene_id: YEL042W
symbol: GDA1
gene_biotype: protein_coding
description:
  Guanosine-diphosphatase; Guanosine diphosphatase located in the Golgi; involved in the transport of GDP-mannose into the Golgi lumen, converting GDP to GMP after mannose is transferred to substrates; null mutants are defective in sporulation and pre-meiotic S phase entry; orthologous to human ENTPD6, a meiosis-associated non-obstructive azoospermia (NOA) related gene identified in GWAS studies; Belongs to the GDA1/CD39 NTPase family.


ensembl_gene_id: YEL043W
symbol: YEL043W
gene_biotype: protein_coding
description:
  Uncharacterized protein YEL043W; Predicted cytoskeleton protein involved in intracellular signaling; based on quantitative analysis of protein-protein interaction maps; may interact with ribosomes, based on co-purification studies; contains fibronectin type III domain fold.


ensembl_gene_id: YEL044W
symbol: IES6
gene_biotype: protein_coding
description:
  Chromatin-remodeling complex subunit IES6; Component of the INO80 chromatin remodeling complex; critical for INO80 function; involved in regulation of chromosome segregation and maintenance of normal centromeric chromatin structure; human ortholog INO80C is a member of the human INO80 complex; implicated in DNA repair based on genetic interactions with RAD52 epistasis genes; Belongs to the IES6 family.


ensembl_gene_id: YEL045C
symbol: YEL045C
gene_biotype: protein_coding
description:
  Uncharacterized protein YEL045C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion gives MMS sensitivity, growth defect under alkaline conditions, less than optimal growth upon citric acid stress.


ensembl_gene_id: YEL046C
symbol: GLY1
gene_biotype: protein_coding
description:
  Low specificity L-threonine aldolase; Threonine aldolase; catalyzes the cleavage of L-allo-threonine and L-threonine to glycine; involved in glycine biosynthesis.


ensembl_gene_id: YEL047C
symbol: FRD1
gene_biotype: protein_coding
description:
  Soluble fumarate reductase; required with isoenzyme Osm1p for anaerobic growth; may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; similar to Arxula adeninovorans fumarate reductase; protein abundance increases in response to DNA replication stress; FRD1 has a paralog, OSM1, that arose from the whole genome duplication; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.


ensembl_gene_id: YEL048C
symbol: TCA17
gene_biotype: protein_coding
description:
  TRAPP-associated protein TCA17; Component of transport protein particle (TRAPP) complex II; TRAPPII is a multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p, regulating intra-Golgi and endosome-Golgi traffic; promotes association of TRAPPII-specific subunits with the TRAPP core complex; sedlin related; human Sedlin mutations cause SEDT, a skeletal disorder.


ensembl_gene_id: YEL049W
symbol: PAU2
gene_biotype: protein_coding
description:
  Seripauperin-2; Member of the seripauperin multigene family; encoded mainly in subtelomeric region; active during alcoholic fermentation; regulated by anaerobiosis; negatively regulated by oxygen; repressed by heme.


ensembl_gene_id: YEL050C
symbol: RML2
gene_biotype: protein_coding
description:
  Mitochondrial ribosomal protein of the large subunit (L2); has similarity to E. coli L2 ribosomal protein; mutant allele (fat21) causes inability to utilize oleate, and induce oleic acid oxidation; may interfere with activity of the Adr1p transcription factor.


ensembl_gene_id: YEL050W-A
symbol: YEL050W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YEL050W-A; Dubious open reading frame unlikely to encode a functional protein; identified by fungal homology and RT-PCR.


ensembl_gene_id: YEL051W
symbol: VMA8
gene_biotype: protein_coding
description:
  Subunit D of the V1 peripheral membrane domain of V-ATPase; part of the electrogenic proton pump found throughout the endomembrane system; plays a role in the coupling of proton transport and ATP hydrolysis; the V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase) has eight subunits.


ensembl_gene_id: YEL052W
symbol: AFG1
gene_biotype: protein_coding
description:
  Protein that may act as a chaperone for cytochrome c oxidase subunits; conserved protein; may act as a chaperone in the degradation of misfolded or unassembled cytochrome c oxidase subunits; localized to matrix face of the mitochondrial inner membrane; member of the AAA family but lacks a protease domain.


ensembl_gene_id: YEL053C
symbol: MAK10
gene_biotype: protein_coding
description:
  N-alpha-acetyltransferase 35, NatC auxiliary subunit; Non-catalytic subunit of the NatC N-terminal acetyltransferase; required for replication of dsRNA virus; expression is glucose-repressible; human NatC ortholog, Naa35, requires co-expression of the human catalytic subunit, Naa30, to functionally complement the null allele; Belongs to the MAK10 family.


ensembl_gene_id: YEL053W-A
symbol: YEL053W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized membrane protein YEL053W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene RPL12A/YEL054C.


ensembl_gene_id: YEL054C
symbol: RPL12A
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L12A; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12A has a paralog, RPL12B, that arose from the whole genome duplication.


ensembl_gene_id: YEL055C
symbol: POL5
gene_biotype: protein_coding
description:
  rDNA transcriptional regulator POL5; DNA Polymerase phi; has sequence similarity to the human MybBP1A and weak sequence similarity to B-type DNA polymerases, not required for chromosomal DNA replication; required for the synthesis of rRNA.


ensembl_gene_id: YEL056W
symbol: HAT2
gene_biotype: protein_coding
description:
  Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing.


ensembl_gene_id: YEL057C
symbol: SDD1
gene_biotype: protein_coding
description:
  Uncharacterized protein YEL057C; Protein of unknown function; overproduction suppresses lethality due to expression of the dominant PET9 allele AAC2-A128P; may have a role in telomere maintenance; target of UME6 regulation.


ensembl_gene_id: YEL058W
symbol: PCM1
gene_biotype: protein_coding
description:
  Essential N-acetylglucosamine-phosphate mutase; converts GlcNAc-6-P to GlcNAc-1-P, which is a precursor for the biosynthesis of chitin and for the formation of N-glycosylated mannoproteins and glycosylphosphatidylinositol anchors.


ensembl_gene_id: YEL059C-A
symbol: SOM1
gene_biotype: protein_coding
description:
  Protein SOM1, mitochondrial; Subunit of the mitochondrial inner membrane peptidase (IMP); IMP is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs.


ensembl_gene_id: YEL059W
symbol: HHY1
gene_biotype: protein_coding
description:
  Hypersensitivity to hygromycin-B protein 1; Dubious open reading frame unlikely to encode a functional protein; mutant is hypersensitive to hygromycin B indicative of defects in vacuolar trafficking.


ensembl_gene_id: YEL060C
symbol: PRB1
gene_biotype: protein_coding
description:
  Cerevisin; Vacuolar proteinase B (yscB) with H3 N-terminal endopeptidase activity; serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation; activity inhibited by Pbi2p; protein abundance increases in response to DNA replication stress; PRB1 has a paralog, YSP3, that arose from the whole genome duplication.


ensembl_gene_id: YEL061C
symbol: CIN8
gene_biotype: protein_coding
description:
  Kinesin-like protein CIN8; Kinesin motor protein; involved in mitotic spindle assembly and chromosome segregation.


ensembl_gene_id: YEL062W
symbol: NPR2
gene_biotype: protein_coding
description:
  Nitrogen permease regulator 2; Subunit of the Iml1p/SEACIT complex; SEACIT (Iml1p-Npr2p-Npr3p) is a subcomplex of the SEA complex, a coatomer-related complex that associates dynamically with the vacuole; Npr2p may have a structural or regulatory role, supporting Iml1p function as a GAP for the Rag family GTPase Gtr1p, and resulting in inhibition of TORC1 signaling in response to amino acid deprivation; SEACIT is required for non-nitrogen-starvation-induced autophagy; homolog of human tumor suppressor NPRL2.


ensembl_gene_id: YEL063C
symbol: CAN1
gene_biotype: protein_coding
description:
  Plasma membrane arginine permease; requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance; CAN1 has a paralog, ALP1, that arose from the whole genome duplication.


ensembl_gene_id: YEL064C
symbol: AVT2
gene_biotype: protein_coding
description:
  Vacuolar amino acid transporter 2; Putative transporter; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters; Belongs to the amino acid/polyamine transporter 2 family.


ensembl_gene_id: YEL065W
symbol: SIT1
gene_biotype: protein_coding
description:
  Siderophore iron transporter 1; Ferrioxamine B transporter; member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p; Belongs to the major facilitator superfamily.


ensembl_gene_id: YEL066W
symbol: HPA3
gene_biotype: protein_coding
description:
  D-amino-acid N-acetyltransferase HPA3; D-Amino acid N-acetyltransferase that detoxifies D-amino acids; catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA is first substrate bound and CoA is last product liberated; acetylates histones and polyamines, also autoacetylates.


ensembl_gene_id: YEL067C
symbol: YEL067C
gene_biotype: protein_coding
description:
  Uncharacterized protein YEL067C; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies.


ensembl_gene_id: YEL068C
symbol: YEL068C
gene_biotype: protein_coding
description:
  Uncharacterized protein YEL068C; Protein of unknown function; expressed at both mRNA and protein levels; SWAT-GFP and seamless-GFP fusion proteins localize to the endoplasmic reticulum and mCherry fusion protein localizes to the vacuole.


ensembl_gene_id: YEL069C
symbol: HXT13
gene_biotype: protein_coding
description:
  Hexose transporter HXT13; Putative transmembrane polyol transporter; supports growth on and uptake of mannitol and sorbitol with moderate affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; induced by non-fermentable carbon sources; induced in low glucose, repressed in high glucose; HXT13 has a paralog, HXT17, that arose from a segmental duplication; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.


ensembl_gene_id: YEL070W
symbol: DSF1
gene_biotype: protein_coding
description:
  Mannitol dehydrogenase; deletion suppresses mutation of mpt5; DSF1 has a paralog, MAN2, that arose from a segmental duplication.


ensembl_gene_id: YEL071W
symbol: DLD3
gene_biotype: protein_coding
description:
  D-2-hydroxyglutarate--pyruvate transhydrogenase DLD3; 2-hydroxyglutarate transhydrogenase, and minor D-lactate dehydrogenase; converts D-2-hydroxyglutarate (D-2HG), an oncometabolite, to alpha-ketoglutarate in the presence of FAD, with concomitant reduction of pyruvate to D-lactate; minor lactate dehydrogenase activity; component of the retrograde regulon that consists of genes whose expression are stimulated by damage to mitochondria and reduced in cells grown with glutamate as the sole nitrogen source; located in the cytoplasm.


ensembl_gene_id: YEL073C
symbol: YEL073C
gene_biotype: protein_coding
description:
  Uncharacterized protein YEL073C; Putative protein of unknown function; located adjacent to ARS503 and the telomere on the left arm of chromosome V; regulated by inositol/choline.


ensembl_gene_id: YEL074W
symbol: YEL074W
gene_biotype: protein_coding
description:
  Putative UPF0320 protein YEL074W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; large scale expression analysis showed an increase in mRNA accumulation in strains mutant for exosome components.


ensembl_gene_id: YEL075W-A
symbol: YEL075W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YEL075W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YEL076C-A
symbol: YEL076C-A
gene_biotype: protein_coding
description:
  Putative protein of unknown function; Belongs to the helicase family. Yeast subtelomeric Y' repeat subfamily.


ensembl_gene_id: YEL077W-A
symbol: YEL077W-A
gene_biotype: protein_coding
description:
  Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching.


ensembl_gene_id: YER001W
symbol: MNN1
gene_biotype: protein_coding
description:
  Alpha-1,3-mannosyltransferase; integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family; Belongs to the MNN1/MNT family.


ensembl_gene_id: YER002W
symbol: NOP16
gene_biotype: protein_coding
description:
  Nucleolar protein 16; Constituent of 66S pre-ribosomal particles; involved in 60S ribosomal subunit biogenesis; Belongs to the NOP16 family.


ensembl_gene_id: YER003C
symbol: PMI40
gene_biotype: protein_coding
description:
  Mannose-6-phosphate isomerase; catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation.


ensembl_gene_id: YER004W
symbol: FMP52
gene_biotype: protein_coding
description:
  Protein FMP52, mitochondrial; Protein of unknown function; localized to the mitochondrial outer membrane; induced by treatment with 8-methoxypsoralen and UVA irradiation; Belongs to the FMP52 family.


ensembl_gene_id: YER005W
symbol: YND1
gene_biotype: protein_coding
description:
  Apyrase with wide substrate specificity; helps prevent inhibition of glycosylation by hydrolyzing nucleoside tri- and diphosphates that inhibit glycotransferases; partially redundant with Gda1p; mediates adenovirus E4orf4-induced toxicity.


ensembl_gene_id: YER006C-A
symbol: YER006C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YER006C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF PAC2/YER007W.


ensembl_gene_id: YER006W
symbol: NUG1
gene_biotype: protein_coding
description:
  Nuclear GTP-binding protein NUG1; GTPase that associates with nuclear 60S pre-ribosomes; required for export of 60S ribosomal subunits from the nucleus.


ensembl_gene_id: YER007C-A
symbol: TMA20
gene_biotype: protein_coding
description:
  Translation machinery-associated protein 20; Protein of unknown function that associates with ribosomes; has a putative RNA binding domain; interacts with Tma22p; null mutant exhibits translation defects; has homology to human oncogene MCT-1; protein abundance increases in response to DNA replication stress; Belongs to the TMA20 family.


ensembl_gene_id: YER007W
symbol: PAC2
gene_biotype: protein_coding
description:
  Protein PAC2; Microtubule effector required for tubulin heterodimer formation; binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl.


ensembl_gene_id: YER008C
symbol: SEC3
gene_biotype: protein_coding
description:
  Subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to sites of exocytosis prior to SNARE-mediated fusion; PtdIns[4,5]P2-binding protein that localizes to exocytic sites in a Rho1p-dependent, actin-independent manner, targeting and anchoring the exocyst to the plasma membrane with Exo70p; direct GTP Rho1p effector; required for ER inheritance; relocalizes away from bud neck upon DNA replication stress; Belongs to the SEC3 family.


ensembl_gene_id: YER009W
symbol: NTF2
gene_biotype: protein_coding
description:
  Nuclear transport factor 2; Nuclear envelope protein; interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport.


ensembl_gene_id: YER010C
symbol: YER010C
gene_biotype: protein_coding
description:
  Bifunctional HMG aldolase/oxaloacetate decarboxylase; requires divalent metal ions for activity; competitively inhibited by oxalate; forms a ring-shaped homotrimer; similar to members of the prokaryotic RraA family of class II (divalent metal ion dependent) pyruvate aldolases from the meta cleavage pathways of protocatechuate and gallate.


ensembl_gene_id: YER011W
symbol: TIR1
gene_biotype: protein_coding
description:
  Cold shock-induced protein TIR1; Cell wall mannoprotein; expression is downregulated at acidic pH and induced by cold shock and anaerobiosis; abundance is increased in cells cultured without shaking; member of the Srp1p/Tip1p family of serine-alanine-rich proteins; Belongs to the SRP1/TIP1 family.


ensembl_gene_id: YER012W
symbol: PRE1
gene_biotype: protein_coding
description:
  Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle; Belongs to the peptidase T1B family.


ensembl_gene_id: YER013W
symbol: PRP22
gene_biotype: protein_coding
description:
  DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase; associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes; required for proofreading the exon ligation reaction.


ensembl_gene_id: YER014C-A
symbol: BUD25
gene_biotype: protein_coding
description:
  Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern.


ensembl_gene_id: YER014W
symbol: HEM14
gene_biotype: protein_coding
description:
  Protoporphyrinogen oxidase; a mitochondrial enzyme that catalyzes the seventh step in the heme biosynthetic pathway, converting protoporphyrinogen IX to protoporphyrin IX; inhibited by diphenyl ether-type herbicides.


ensembl_gene_id: YER015W
symbol: FAA2
gene_biotype: protein_coding
description:
  Long-chain-fatty-acid--CoA ligase 2; Medium chain fatty acyl-CoA synthetase; activates imported fatty acids; accepts a wide range of fatty acid chain lengths with a preference for medium chains, C9:0-C13:0; localized to the peroxisome; comparative analysis suggests that a mitochondrially targeted form may result from translation starting at a non-canonical codon upstream of the annotated start codon.


ensembl_gene_id: YER016W
symbol: BIM1
gene_biotype: protein_coding
description:
  Protein BIM1; Microtubule plus end-tracking protein; together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally; homolog of human end binding protein 1 (EB1); Belongs to the MAPRE family.


ensembl_gene_id: YER017C
symbol: AFG3
gene_biotype: protein_coding
description:
  Mitochondrial respiratory chain complexes assembly protein AFG3; Mitochondrial inner membrane m-AAA protease component; mediates degradation of misfolded or unassembled proteins; also required for correct assembly of mitochondrial enzyme complexes; involved in cytoplasmic mRNA translation and aging; expression of human homolog AFG3L2 can complement yeast yta12 afg3 double mutant; In the N-terminal section; belongs to the AAA ATPase family.


ensembl_gene_id: YER018C
symbol: SPC25
gene_biotype: protein_coding
description:
  Kinetochore protein SPC25; Component of the kinetochore-associated Ndc80 complex; involved in chromosome segregation, spindle checkpoint activity, and kinetochore clustering; evolutionarily conserved; other members include Ndc80p, Nuf2p, Spc24p, and Spc25p.


ensembl_gene_id: YER019C-A
symbol: SBH2
gene_biotype: protein_coding
description:
  Ssh1p-Sss1p-Sbh2p complex component; involved in protein translocation into the endoplasmic reticulum; SBH2 has a paralog, SBH1, that arose from the whole genome duplication; Belongs to the SEC61-beta family.


ensembl_gene_id: YER019W
symbol: ISC1
gene_biotype: protein_coding
description:
  Inositol phosphosphingolipid phospholipase C; mitochondrial membrane localized; hydrolyzes complex sphingolipids to produce ceramide; activates genes required for non-fermentable carbon source metabolism during diauxic shift; activated by phosphatidylserine, cardiolipin, and phosphatidylglycerol; mediates Na+ and Li+ halotolerance; ortholog of mammalian neutral sphingomyelinase type 2.


ensembl_gene_id: YER020W
symbol: GPA2
gene_biotype: protein_coding
description:
  Guanine nucleotide-binding protein alpha-2 subunit; Nucleotide binding alpha subunit of the heterotrimeric G protein; interacts with the receptor Gpr1p, has signaling role in response to nutrients; required for the recruitment of Ras-GTP at the plasma membrane and in the nucleus.


ensembl_gene_id: YER021W
symbol: RPN3
gene_biotype: protein_coding
description:
  Essential non-ATPase regulatory subunit of the 26S proteasome lid; similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control.


ensembl_gene_id: YER022W
symbol: SRB4
gene_biotype: protein_coding
description:
  Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for basal RNA polymerase II transcription; homozygosity of the human MED17 L371P mutation is associated with infantile cerebral and cerebellar atrophy with poor myelination.


ensembl_gene_id: YER023C-A
symbol: YER023C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YER023C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps verified gene PRO3; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching.


ensembl_gene_id: YER024W
symbol: YAT2
gene_biotype: protein_coding
description:
  Carnitine O-acetyltransferase YAT2; Carnitine acetyltransferase; has similarity to Yat1p, which is a carnitine acetyltransferase associated with the mitochondrial outer membrane.


ensembl_gene_id: YER025W
symbol: GCD11
gene_biotype: protein_coding
description:
  Gamma subunit of the translation initiation factor eIF2; involved in the identification of the start codon; binds GTP when forming the ternary complex with GTP and tRNAi-Met; mutations in human ortholog cause X-linked intellectual disability (XLID); Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.


ensembl_gene_id: YER026C
symbol: CHO1
gene_biotype: protein_coding
description:
  CDP-diacylglycerol--serine O-phosphatidyltransferase; Phosphatidylserine synthase; functions in phospholipid biosynthesis; catalyzes the reaction CDP-diaclyglycerol + L-serine = CMP + L-1-phosphatidylserine, transcriptionally repressed by myo-inositol and choline.


ensembl_gene_id: YER027C
symbol: GAL83
gene_biotype: protein_coding
description:
  One of three possible beta-subunits of the Snf1 kinase complex; allows nuclear localization of the Snf1 kinase complex in the presence of a nonfermentable carbon source; necessary and sufficient for phosphorylation of the Mig2p transcription factor in response to alkaline stress; functionally redundant with SIP1 and SIP2 for the phosphorylation of Mig1p in response to glucose deprivation; contains a glycogen-binding domain.


ensembl_gene_id: YER028C
symbol: MIG3
gene_biotype: protein_coding
description:
  Transcription corepressor MIG3; Transcriptional regulator; partially nonfunctional in S288C strains but has a major role in catabolite repression and ethanol response in some other strains; involved in response to toxic agents; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genesenvironment; Belongs to the creA/MIG C2H2-type zinc-finger protein family.


ensembl_gene_id: YER029C
symbol: SMB1
gene_biotype: protein_coding
description:
  Small nuclear ribonucleoprotein-associated protein B; Core Sm protein Sm B; part of heteroheptameric complex (with Smd1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm B and Sm B'; Belongs to the snRNP SmB/SmN family.


ensembl_gene_id: YER030W
symbol: CHZ1
gene_biotype: protein_coding
description:
  Histone chaperone for Htz1p/H2A-H2B dimer; required for the stabilization of the Chz1p-Htz1-H2B complex; has overlapping function with Nap1p; null mutant displays weak sensitivity to MMS and benomyl; contains a highly conserved CHZ motif; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YER031C
symbol: YPT31
gene_biotype: protein_coding
description:
  GTP-binding protein YPT31/YPT8; Rab family GTPase; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; YPT31 has a paralog, YPT32, that arose from the whole genome duplication; localizes to the transitional and late Golgi.


ensembl_gene_id: YER032W
symbol: FIR1
gene_biotype: protein_coding
description:
  Factor interacting with REF2; Protein involved in 3' mRNA processing; interacts with Ref2p; APCC(Cdh1) substrate; potential Cdc28p substrate.


ensembl_gene_id: YER033C
symbol: ZRG8
gene_biotype: protein_coding
description:
  Zinc-regulated protein 8; Protein of unknown function; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GFP-fusion protein is localized to the cytoplasm; transcription induced under conditions of zinc deficiency.


ensembl_gene_id: YER034W
symbol: YER034W
gene_biotype: protein_coding
description:
  Uncharacterized protein YER034W; Protein of unknown function; non-essential gene; expression induced upon calcium shortage; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YER035W
symbol: EDC2
gene_biotype: protein_coding
description:
  Enhancer of mRNA-decapping protein 2; RNA-binding protein that directly activates mRNA decapping; binds mRNA substrate and enhances activity of decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein increases in abundance and relocalizes to nucleolus and to nuclear foci upon DNA replication stress; EDC2 has a paralog, EDC1, that arose from the whole genome duplication.


ensembl_gene_id: YER036C
symbol: ARB1
gene_biotype: protein_coding
description:
  ABC transporter ATP-binding protein ARB1; ATPase of the ATP-binding cassette (ABC) family; involved in 40S and 60S ribosome biogenesis, has similarity to Gcn20p; shuttles from nucleus to cytoplasm, physically interacts with Tif6p, Lsg1p; human homolog ABCF2 can complement yeast ARB1 mutant; Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.


ensembl_gene_id: YER037W
symbol: PHM8
gene_biotype: protein_coding
description:
  Phosphate metabolism protein 8; Lysophosphatidic acid (LPA) phosphatase, nucleotidase; principle and physiological nucleotidase working on GMP, UMP and CMP; involved in LPA hydrolysis in response to phosphate starvation and ribose salvage pathway; phosphatase activity is soluble and Mg2+ dependent; expression is induced by low phosphate levels and by inactivation of Pho85p; repressed by Gcn4p under normal conditions; PHM8 has a paralog, SDT1, that arose from the whole genome duplication.


ensembl_gene_id: YER038C
symbol: KRE29
gene_biotype: protein_coding
description:
  DNA repair protein KRE29; Subunit of the SMC5-SMC6 complex; this complex is involved in removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance.


ensembl_gene_id: YER039C
symbol: HVG1
gene_biotype: protein_coding
description:
  Probable GDP-mannose transporter 2; Protein of unknown function; HVG1 has a paralog, VRG4, that arose from the whole genome duplication; Belongs to the TPT transporter family. SLC35D subfamily.


ensembl_gene_id: YER039C-A
symbol: YER039C-A
gene_biotype: protein_coding
description:
  Putative protein of unknown function; YER039C-A is not an essential gene; Belongs to the TPT transporter family. SLC35D subfamily.


ensembl_gene_id: YER040W
symbol: GLN3
gene_biotype: protein_coding
description:
  Nitrogen regulatory protein GLN3; Transcriptional activator of genes regulated by nitrogen catabolite repression; localization and activity regulated by quality of nitrogen source and Ure2p.


ensembl_gene_id: YER041W
symbol: YEN1
gene_biotype: protein_coding
description:
  Holliday junction resolvase; promotes template switching during break-induced replication (BIR), causing non-reciprocal translocations (NRTs); localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1; similar to S. cerevisiae endonuclease Rth1p.


ensembl_gene_id: YER042W
symbol: MXR1
gene_biotype: protein_coding
description:
  Methionine-S-sulfoxide reductase; involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR2; involved in the regulation of lifespan; reduced activity of human homolog implicated in Alzheimer disease.


ensembl_gene_id: YER043C
symbol: SAH1
gene_biotype: protein_coding
description:
  Adenosylhomocysteinase; S-adenosyl-L-homocysteine hydrolase; catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor; regulates cellular lipid homoeostasis by regulating phosphatidylcholine(PC)synthesis and triacylglycerol (TG) levels.


ensembl_gene_id: YER044C
symbol: ERG28
gene_biotype: protein_coding
description:
  Ergosterol biosynthetic protein 28; Endoplasmic reticulum membrane protein; may facilitate protein-protein interactions between the Erg26p dehydrogenase and the Erg27p 3-ketoreductase and/or tether these enzymes to the ER, also interacts with Erg6p.


ensembl_gene_id: YER044C-A
symbol: MEI4
gene_biotype: protein_coding
description:
  Meiosis-specific protein involved in forming DSBs; involved in double-strand break (DSBs) formation during meiotic recombination; required for chromosome synapsis and production of viable spores.


ensembl_gene_id: YER045C
symbol: ACA1
gene_biotype: protein_coding
description:
  ATF/CREB activator 1; ATF/CREB family basic leucine zipper (bZIP) transcription factor; binds as a homodimer to the ATF/CREB consensus sequence TGACGTCA; important for carbon source utilization; target genes include GRE2 and COS8; ACA1 has a paralog, CST6, that arose from the whole genome duplication.


ensembl_gene_id: YER046W
symbol: SPO73
gene_biotype: protein_coding
description:
  Sporulation-specific protein 73; Meiosis-specific protein required for prospore membrane morphogenesis; required for the proper shape of the prospore membrane (PSM) and for spore wall formation; functions cooperatively with SPO71 in PSM elongation; physically interacts with Spo71p; genetically antagonistic to SPO1, similar to SPO71; localizes to the PSM; required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis; dysferlin domain-only protein; Belongs to the SPO73 family.


ensembl_gene_id: YER046W-A
symbol: YER046W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YER046W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF SAP1/YER047C.


ensembl_gene_id: YER047C
symbol: SAP1
gene_biotype: protein_coding
description:
  Protein SAP1; Putative ATPase of the AAA family; interacts with the Sin1p transcriptional repressor in the two-hybrid system.


ensembl_gene_id: YER048C
symbol: CAJ1
gene_biotype: protein_coding
description:
  Protein CAJ1; Nuclear type II J heat shock protein of the E. coli dnaJ family; contains a leucine zipper-like motif, binds to non-native substrates for presentation to Ssa3p, may function during protein translocation, assembly and disassembly.


ensembl_gene_id: YER048W-A
symbol: ISD11
gene_biotype: protein_coding
description:
  Protein ISD11; Cysteine desulfurase (Nfs1p) activator; essential for the formation of the persulfide intermediate at the desulfurase active site during pyridoxal phosphate-dependent desulfuration of cysteine; required for mitochondrial iron-sulfur cluster biosynthesis; exclusive to eukaryotes, implicated as eukaryotic supplement to the bacterium-derived Fe-S cluster (ISC) assembly apparatus; involved in regulation of iron metabolism; member of the LYR protein family.


ensembl_gene_id: YER049W
symbol: TPA1
gene_biotype: protein_coding
description:
  Prolyl 3,4-dihydroxylase TPA1; Fe(II)/2-oxoglutarate-dependent dioxygenase family member; catalyzes the repair of methyl-base lesions in both ss and dsDNA by oxidative demethylation; Poly(rA)-binding protein involved in mRNA poly(A) tail length and mRNA stability; role in translation termination efficiency; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; similar to human prolyl 4-hydroxylase OGFOD1; binds Fe(II) and 2-oxoglutarate.


ensembl_gene_id: YER050C
symbol: RSM18
gene_biotype: protein_coding
description:
  Mitochondrial ribosomal protein of the small subunit; has similarity to E. coli S18 ribosomal protein.


ensembl_gene_id: YER051W
symbol: JHD1
gene_biotype: protein_coding
description:
  JmjC domain family histone demethylase specific for H3-K36; similar to proteins found in human, mouse, drosophila, X. laevis, C. elegans, and S. pombe; Belongs to the JHDM1 histone demethylase family.


ensembl_gene_id: YER052C
symbol: HOM3
gene_biotype: protein_coding
description:
  Aspartokinase; Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis; Belongs to the aspartokinase family.


ensembl_gene_id: YER053C
symbol: PIC2
gene_biotype: protein_coding
description:
  Mitochondrial copper and phosphate carrier; imports copper and inorganic phosphate into mitochondria; functionally redundant with Mir1p but less abundant than Mir1p under normal conditions; expression is induced at high temperature.


ensembl_gene_id: YER053C-A
symbol: YER053C-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YER053C-A; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YER054C
symbol: GIP2
gene_biotype: protein_coding
description:
  GLC7-interacting protein 2; Putative regulatory subunit of protein phosphatase Glc7p; involved in glycogen metabolism; contains a conserved motif (GVNK motif) that is also found in Gac1p, Pig1p, and Pig2p; GIP2 has a paralog, PIG2, that arose from the whole genome duplication.


ensembl_gene_id: YER055C
symbol: HIS1
gene_biotype: protein_coding
description:
  ATP phosphoribosyltransferase; a hexameric enzyme, catalyzes the first step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control.


ensembl_gene_id: YER056C
symbol: FCY2
gene_biotype: protein_coding
description:
  Purine-cytosine permease; mediates purine (adenine, guanine, and hypoxanthine) and cytosine accumulation; relative distribution to the vacuole increases upon DNA replication stress.


ensembl_gene_id: YER056C-A
symbol: RPL34A
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L34A; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34A has a paralog, RPL34B, that arose from the whole genome duplication.


ensembl_gene_id: YER057C
symbol: HMF1
gene_biotype: protein_coding
description:
  Protein HMF1; Member of the p14.5 protein family; functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high-dosage growth inhibitor; forms a homotrimer in vitro; HMF1 has a paralog, MMF1, that arose from the whole genome duplication; Belongs to the RutC family.


ensembl_gene_id: YER058W
symbol: PET117
gene_biotype: protein_coding
description:
  Protein PET117, mitochondrial; Protein required for assembly of cytochrome c oxidase; Belongs to the PET117 family.


ensembl_gene_id: YER059W
symbol: PCL6
gene_biotype: protein_coding
description:
  Pho85p cyclin of the Pho80p subfamily; forms the major Glc8p kinase together with Pcl7p and Pho85p; involved in the control of glycogen storage by Pho85p; stabilized by Elongin C binding; PCL6 has a paralog, PCL7, that arose from the whole genome duplication.


ensembl_gene_id: YER060W
symbol: FCY21
gene_biotype: protein_coding
description:
  Putative purine-cytosine permease; very similar to Fcy2p but cannot substitute for its function; Belongs to the purine-cytosine permease (2.A.39) family.


ensembl_gene_id: YER061C
symbol: CEM1
gene_biotype: protein_coding
description:
  3-oxoacyl-[acyl-carrier-protein] synthase homolog; Mitochondrial beta-keto-acyl synthase; possible role in fatty acid synthesis; required for mitochondrial respiration; human homolog OXSM can complement yeast cem1 null mutant; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.


ensembl_gene_id: YER062C
symbol: GPP2
gene_biotype: protein_coding
description:
  Glycerol-1-phosphate phosphohydrolase 2; DL-glycerol-3-phosphate phosphatase involved in glycerol biosynthesis; also known as glycerol-1-phosphatase; induced in response to hyperosmotic or oxidative stress, and during diauxic shift; GPP2 has a paralog, GPP1, that arose from the whole genome duplication; Belongs to the HAD-like hydrolase superfamily. DOG/GPP family.


ensembl_gene_id: YER063W
symbol: THO1
gene_biotype: protein_coding
description:
  Protein THO1; Conserved nuclear RNA-binding protein; specifically binds to transcribed chromatin in a THO- and RNA-dependent manner, genetically interacts with shuttling hnRNP NAB2; overproduction suppresses transcriptional defect caused by hpr1 mutation.


ensembl_gene_id: YER064C
symbol: VHR2
gene_biotype: protein_coding
description:
  Transcription factor VHR2; Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress.


ensembl_gene_id: YER065C
symbol: ICL1
gene_biotype: protein_coding
description:
  Isocitrate lyase; catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose.


ensembl_gene_id: YER066C-A
symbol: YER066C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YER066C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YER067W.


ensembl_gene_id: YER066W
symbol: RRT13
gene_biotype: protein_coding
description:
  Regulator of rDNA transcription protein 13; Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription.


ensembl_gene_id: YER067C-A
symbol: YER067C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized membrane protein YER067C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps ORF RGI1/YER067W.


ensembl_gene_id: YER067W
symbol: RGI1
gene_biotype: protein_coding
description:
  Respiratory growth induced protein 1; Protein of unknown function; involved in energy metabolism under respiratory conditions; protein abundance is increased upon intracellular iron depletion or in response to DNA replication stress; RGI1 has a paralog, RGI2, that arose from the whole genome duplication.


ensembl_gene_id: YER068C-A
symbol: YER068C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized membrane protein YER068C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF ARG5,6/YER069W.


ensembl_gene_id: YER068W
symbol: MOT2
gene_biotype: protein_coding
description:
  General negative regulator of transcription subunit 4; Ubiquitin-protein ligase subunit of the CCR4-NOT complex; with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p; CCR4-NOT has roles in transcription regulation, mRNA degradation, and post-transcriptional modifications; regulates levels of DNA Polymerase-{alpha} to promote efficient and accurate DNA replication.


ensembl_gene_id: YER069W
symbol: ARG5,6
gene_biotype: protein_coding
description:
  Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the 3rd step in arginine biosynthesis; synthesized as a precursor which is processed in the mitochondrion to yield mature NAGK and NAGSA; enzymes form a metabolon complex with Arg2p; NAGK C-terminal domain stabilizes the enzymes, slows catalysis and is involved in feed-back inhibition by arginine.


ensembl_gene_id: YER070W
symbol: RNR1
gene_biotype: protein_coding
description:
  Ribonucleoside-diphosphate reductase large chain 1; Major isoform of large subunit of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits; relative distribution to the nucleus increases upon DNA replication stress; RNR1 has a paralog, RNR3, that arose from the whole genome duplication.


ensembl_gene_id: YER071C
symbol: TDA2
gene_biotype: protein_coding
description:
  Topoisomerase I damage affected protein 2; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; null mutant is sensitive to expression of the top1-T722A allele.


ensembl_gene_id: YER072W
symbol: VTC1
gene_biotype: protein_coding
description:
  Regulatory subunit of the vacuolar transporter chaperone (VTC) complex; VTC complex is involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion; also has mRNA binding activity; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YER073W
symbol: ALD5
gene_biotype: protein_coding
description:
  Mitochondrial aldehyde dehydrogenase; involved in regulation or biosynthesis of electron transport chain components and acetate formation; activated by K+; utilizes NADP+ as the preferred coenzyme; constitutively expressed.


ensembl_gene_id: YER074W
symbol: RPS24A
gene_biotype: protein_coding
description:
  Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S24, no bacterial homolog; RPS24A has a paralog, RPS24B, that arose from the whole genome duplication.


ensembl_gene_id: YER074W-A
symbol: YOS1
gene_biotype: protein_coding
description:
  Integral membrane protein required for ER to Golgi transport; localized to the Golgi, the ER, and COPII vesicles; interacts with Yip1p and Yif1p.


ensembl_gene_id: YER075C
symbol: PTP3
gene_biotype: protein_coding
description:
  Tyrosine-protein phosphatase 3; Phosphotyrosine-specific protein phosphatase; involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the cytoplasm.


ensembl_gene_id: YER076C
symbol: YER076C
gene_biotype: protein_coding
description:
  Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; analysis of HA-tagged protein suggests a membrane localization; To yeast killer toxin KHR.


ensembl_gene_id: YER076W-A
symbol: YER076W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized membrane protein YER076W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER076C.


ensembl_gene_id: YER077C
symbol: MRX1
gene_biotype: protein_coding
description:
  MIOREX complex component 1; Protein that associates with mitochondrial ribosome; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; null mutation results in a decrease in plasma membrane electron transport.


ensembl_gene_id: YER078C
symbol: ICP55
gene_biotype: protein_coding
description:
  Intermediate cleaving peptidase 55; Mitochondrial aminopeptidase; cleaves the N termini of at least 38 imported proteins after cleavage by the mitochondrial processing peptidase (MPP), thereby increasing their stability; member of the aminopeptidase P family.


ensembl_gene_id: YER078W-A
symbol: YER078W-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YER078W-A; Putative protein of unknown function; identified by fungal homology and RT-PCR.


ensembl_gene_id: YER079C-A
symbol: YER079C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized membrane protein YER079C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps ORF AIM9/YER080W.


ensembl_gene_id: YER080W
symbol: AIM9
gene_biotype: protein_coding
description:
  Altered inheritance of mitochondria protein 9, mitochondrial; Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss.


ensembl_gene_id: YER081W
symbol: SER3
gene_biotype: protein_coding
description:
  D-3-phosphoglycerate dehydrogenase 1; 3-phosphoglycerate dehydrogenase and alpha-ketoglutarate reductase; 3PG dehydrogenase that catalyzes the first step in serine and glycine biosynthesis; also functions as an alpha-ketoglutarate reductase, converting alpha-ketoglutarate to D-2-hydroxyglutarate (D-2HG); localizes to the cytoplasm; SER3 has a paralog, SER33, that arose from the whole genome duplication.


ensembl_gene_id: YER083C
symbol: GET2
gene_biotype: protein_coding
description:
  Golgi to ER traffic protein 2; Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for meiotic nuclear division; Belongs to the GET2 family.


ensembl_gene_id: YER084W
symbol: YER084W
gene_biotype: protein_coding
description:
  Uncharacterized protein YER084W; Protein of unknown function; expressed at both mRNA and protein levels.


ensembl_gene_id: YER084W-A
symbol: YER084W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized membrane protein YER084W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps uncharacterized ORF YER085C.


ensembl_gene_id: YER086W
symbol: ILV1
gene_biotype: protein_coding
description:
  Threonine dehydratase, mitochondrial; Threonine deaminase, catalyzes first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation; Belongs to the serine/threonine dehydratase family.


ensembl_gene_id: YER087C-A
symbol: YER087C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YER087C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF AIM10/YER087W.


ensembl_gene_id: YER087C-B
symbol: SBH1
gene_biotype: protein_coding
description:
  Protein transport protein SBH1; Beta subunit of Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p); involved in protein translocation into the endoplasmic reticulum; interacts with the exocyst complex and also with Rtn1p; cotranslationally N-acetylated by NatA; SBH1 has a paralog, SBH2, that arose from the whole genome duplication; Belongs to the SEC61-beta family.


ensembl_gene_id: YER087W
symbol: AIM10
gene_biotype: protein_coding
description:
  Probable proline--tRNA ligase, mitochondrial; Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss.


ensembl_gene_id: YER088C
symbol: DOT6
gene_biotype: protein_coding
description:
  Transcriptional regulatory protein DOT6; Protein involved in rRNA and ribosome biogenesis; activated in stochastic pulses of nuclear localization; binds polymerase A and C motif; subunit of the RPD3L histone deacetylase complex; has chromatin specific SANT domain; involved in telomeric gene silencing and filamentation; relative distribution to the nucleus increases upon DNA replication stress; Belongs to the DOT6 family.


ensembl_gene_id: YER088C-A
symbol: YER088C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YER088C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORFs PTC2/YER089C and YER088W-B.


ensembl_gene_id: YER088W-B
symbol: YER088W-B
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YER088W-B; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the ORF PTC2/YER089C; identified by gene-trapping, expression analysis, and homology searching.


ensembl_gene_id: YER089C
symbol: PTC2
gene_biotype: protein_coding
description:
  Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p to limit maximal osmostress induced kinase activity; dephosphorylates Ire1p to downregulate the unfolded protein response; dephosphorylates Cdc28p; inactivates the DNA damage checkpoint; PTC2 has a paralog, PTC3, that arose from the whole genome duplication.


ensembl_gene_id: YER090C-A
symbol: YER090C-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YER090C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YER090W
symbol: TRP2
gene_biotype: protein_coding
description:
  Anthranilate synthase; catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p.


ensembl_gene_id: YER091C
symbol: MET6
gene_biotype: protein_coding
description:
  5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; Cobalamin-independent methionine synthase; involved in methionine biosynthesis and regeneration; requires a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to bacterial metE homologs.


ensembl_gene_id: YER091C-A
symbol: YER091C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YER091C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YER092W
symbol: IES5
gene_biotype: protein_coding
description:
  Ino eighty subunit 5; Non-essential INO80 chromatin remodeling complex subunit; deletion affects telomere maintenance via recombination.


ensembl_gene_id: YER093C
symbol: TSC11
gene_biotype: protein_coding
description:
  Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p); TORC2 is a membrane-associated complex that regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; involved in sphingolipid metabolism; contains a RasGEFN domain; Belongs to the RICTOR family.


ensembl_gene_id: YER093C-A
symbol: AIM11
gene_biotype: protein_coding
description:
  Protein of unknown function; null mutant is viable but shows increased loss of mitochondrial genome and synthetic interaction with prohibitin (phb1); contains an intron; SWAT-GFP and mCherry fusion proteins localize to the mitochondria; YER093C-A has a paralog, YBL059W, that arose from the whole genome duplication.


ensembl_gene_id: YER094C
symbol: PUP3
gene_biotype: protein_coding
description:
  Beta 3 subunit of the 20S proteasome; involved in ubiquitin-dependent catabolism; human homolog is subunit C10.


ensembl_gene_id: YER095W
symbol: RAD51
gene_biotype: protein_coding
description:
  DNA repair protein RAD51; Strand exchange protein; forms a helical filament with DNA that searches for homology; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; homolog of Dmc1p and bacterial RecA protein.


ensembl_gene_id: YER096W
symbol: SHC1
gene_biotype: protein_coding
description:
  Protein SHC1; Sporulation-specific activator of Chs3p (chitin synthase III); required for the synthesis of the chitosan layer of ascospores; transcriptionally induced at alkaline pH; SHC1 has a paralog, SKT5, that arose from the whole genome duplication.


ensembl_gene_id: YER097W
symbol: YER097W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YER097W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YER098W
symbol: UBP9
gene_biotype: protein_coding
description:
  Ubiquitin-specific protease that cleaves ubiquitin-protein fusions; UBP9 has a paralog, UBP13, that arose from the whole genome duplication; Belongs to the peptidase C19 family.


ensembl_gene_id: YER099C
symbol: PRS2
gene_biotype: protein_coding
description:
  Ribose-phosphate pyrophosphokinase 2; 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP; which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS2 has a paralog, PRS4, that arose from the whole genome duplication.


ensembl_gene_id: YER100W
symbol: UBC6
gene_biotype: protein_coding
description:
  Ubiquitin-conjugating enzyme involved in ERAD; located at the cytosolic side of the ER membrane; tail region contains a transmembrane segment at the C-terminus; substrate of the ubiquitin-proteasome pathway; ER-associated protein degradation is also known as ERAD.


ensembl_gene_id: YER101C
symbol: AST2
gene_biotype: protein_coding
description:
  Protein AST2; Lipid raft associated protein; overexpression restores Pma1p localization to lipid rafts which is required for targeting of Pma1p to the plasma membrane; sometimes classified in the medium-chain dehydrogenase/reductases (MDRs) superfamily; AST2 has a paralog, AST1, that arose from the whole genome duplication.


ensembl_gene_id: YER102W
symbol: RPS8B
gene_biotype: protein_coding
description:
  Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S8, no bacterial homolog; RPS8B has a paralog, RPS8A, that arose from the whole genome duplication.


ensembl_gene_id: YER103W
symbol: SSA4
gene_biotype: protein_coding
description:
  Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the HSP70 family; cytoplasmic protein that concentrates in nuclei upon starvation; SSA4 has a paralog, SSA3, that arose from the whole genome duplication.


ensembl_gene_id: YER105C
symbol: NUP157
gene_biotype: protein_coding
description:
  Nucleoporin NUP157; Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and tethering of DNA to the nuclear periphery; both Nup170p and NUP157p are similar to human Nup155p; NUP157 has a paralog, NUP170, that arose from the whole genome duplication; Belongs to the non-repetitive/WGA-negative nucleoporin family.


ensembl_gene_id: YER106W
symbol: MAM1
gene_biotype: protein_coding
description:
  Monopolin complex subunit MAM1; Monopolin; meiosis-specific kinetochore-associated protein involved in monopolar attachment of sister kinetochores to the meiotic spindle; subunit of monopolin, a complex that prevents biorientation of sister kinetochores to ensure homolog biorientation during meiosis I; regulates the conformation, enzyme kinetics and substrate specificity of the Dsn1p kinase, Hrr1p; expressed only during the first meiotic division.


ensembl_gene_id: YER107C
symbol: GLE2
gene_biotype: protein_coding
description:
  Nucleoporin GLE2; RNA export factor associated with the nuclear pore complex (NPC); associates with NUP116p; required for polyadenylated RNA export but not for protein import; homologous to S. pombe Rae1p and human RAE1.


ensembl_gene_id: YER107W-A
symbol: YER107W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized membrane protein YER107W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified ORF GLE2/YER107C.


ensembl_gene_id: YER110C
symbol: KAP123
gene_biotype: protein_coding
description:
  Importin subunit beta-4; Karyopherin beta; mediates nuclear import of ribosomal proteins prior to assembly into ribosomes and import of histones H3 and H4; localizes to the nuclear pore, nucleus, and cytoplasm; exhibits genetic interactions with RAI1.


ensembl_gene_id: YER111C
symbol: SWI4
gene_biotype: protein_coding
description:
  Regulatory protein SWI4; DNA binding component of the SBF complex (Swi4p-Swi6p); a transcriptional activator that in concert with MBF (Mbp1-Swi6p) regulates late G1-specific transcription of targets including cyclins and genes required for DNA synthesis and repair; Slt2p-independent regulator of cold growth; acetylation at two sites, K1016 and K1066, regulates interaction with Swi6p.


ensembl_gene_id: YER112W
symbol: LSM4
gene_biotype: protein_coding
description:
  U6 snRNA-associated Sm-like protein LSm4; Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; forms cytoplasmic foci upon DNA replication stress.


ensembl_gene_id: YER113C
symbol: TMN3
gene_biotype: protein_coding
description:
  Transmembrane 9 superfamily member 3; Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn2p; member of Transmembrane Nine family with 9 transmembrane segments; localizes to Golgi; induced by 8-methoxypsoralen plus UVA irradiation; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.


ensembl_gene_id: YER114C
symbol: BOI2
gene_biotype: protein_coding
description:
  Protein implicated in polar growth, functionally redundant with Boi1p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; BOI2 has a paralog, BOI1, that arose from the whole genome duplication.


ensembl_gene_id: YER115C
symbol: SPR6
gene_biotype: protein_coding
description:
  Protein of unknown function; expressed during sporulation; not required for sporulation, but gene exhibits genetic interactions with other genes required for sporulation.


ensembl_gene_id: YER116C
symbol: SLX8
gene_biotype: protein_coding
description:
  Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex; role in proteolysis of spindle positioning protein Kar9, DNA repair proteins Rad52p and Rad57p; stimulated by SUMO-modified substrates; contains a C-terminal RING domain; forms nuclear foci upon DNA replication stress; required for maintenance of genome integrity like human ortholog RNF.


ensembl_gene_id: YER117W
symbol: RPL23B
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L23B; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23B has a paralog, RPL23A, that arose from the whole genome duplication.


ensembl_gene_id: YER118C
symbol: SHO1
gene_biotype: protein_coding
description:
  High osmolarity signaling protein SHO1; Transmembrane osmosensor for filamentous growth and HOG pathways; involved in activation of the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol (HOG) response pathway; phosphorylated by Hog1p; interacts with Pbs2p, Msb2p, Hkr1p, and Ste11p.


ensembl_gene_id: YER119C
symbol: AVT6
gene_biotype: protein_coding
description:
  Vacuolar amino acid transporter 6; Vacuolar aspartate and glutamate exporter; member of a family of seven genes (AVT1-7) related to vesicular GABA-glycine transporters; involved in compartmentalizing acidic amino acids in response to nitrogen starvation; AVT6 has a paralog, AVT5, that arose from the whole genome duplication.


ensembl_gene_id: YER119C-A
symbol: YER119C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YER119C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene SCS2.


ensembl_gene_id: YER120W
symbol: SCS2
gene_biotype: protein_coding
description:
  Integral ER membrane protein, regulates phospholipid metabolism; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to plasma membrane (PM) and regulate PI4P levels by controlling access of Sac1p phosphatase to substrate PI4P in the PM; interacts with FFAT motifs in Opi1p, Swh1p, Osh2p, and Osh3p; involved in telomeric silencing; VAP homolog; SCS2 has a paralog, SCS22, that arose from the whole genome duplication; Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.


ensembl_gene_id: YER121W
symbol: YER121W
gene_biotype: protein_coding
description:
  Uncharacterized protein YER121W; Putative protein of unknown function; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy.


ensembl_gene_id: YER122C
symbol: GLO3
gene_biotype: protein_coding
description:
  ADP-ribosylation factor GTPase activating protein (ARF GAP); involved in ER-Golgi transport; shares functional similarity with Gcs1p.


ensembl_gene_id: YER123W
symbol: YCK3
gene_biotype: protein_coding
description:
  Casein kinase I homolog 3; Palmitoylated vacuolar membrane-localized casein kinase I isoform; negatively regulates vacuole fusion during hypertonic stress via phosphorylation of Vps41p; shares essential functions with Hrr25p; regulates vesicle fusion in AP-3 pathway; Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.


ensembl_gene_id: YER124C
symbol: DSE1
gene_biotype: protein_coding
description:
  Protein DSE1; Daughter cell-specific protein; may regulate cross-talk between the mating and filamentation pathways; deletion affects cell separation after division and sensitivity to alpha-factor and drugs affecting the cell wall; relocalizes from bud neck to cytoplasm upon DNA replication stress; Belongs to the WD repeat DSE1 family.


ensembl_gene_id: YER125W
symbol: RSP5
gene_biotype: protein_coding
description:
  NEDD4 family E3 ubiquitin ligase; regulates processes including: MVB sorting, the heat shock response, transcription, endocytosis and ribosome stability; ubiquitinates Sec23p, Sna3p, Ste4p, Nfi1p, Rpo21p and Sem1p; autoubiquitinates; deubiquitinated by Ubp2p; regulated by SUMO ligase Siz1p, in turn regulates Siz1p SUMO ligase activity; required for efficient Golgi-to-ER trafficking in COPI mutants; mutant tolerates aneuploidy; human homolog implicated in Liddle syndrome; Belongs to the RSP5/NEDD4 family.


ensembl_gene_id: YER126C
symbol: NSA2
gene_biotype: protein_coding
description:
  Ribosome biogenesis protein NSA2; Protein constituent of 66S pre-ribosomal particles; contributes to processing of the 27S pre-rRNA; recruited by ribosomal proteins L17, L35, and L37 to assembling ribosomes after 27SB pre-rRNA is generated, immediately preceding removal of ITS2.


ensembl_gene_id: YER127W
symbol: LCP5
gene_biotype: protein_coding
description:
  U3 small nucleolar ribonucleoprotein protein LCP5; Essential protein involved in maturation of 18S rRNA; depletion leads to inhibited pre-rRNA processing and reduced polysome levels; localizes primarily to the nucleolus.


ensembl_gene_id: YER128W
symbol: VFA1
gene_biotype: protein_coding
description:
  VPS4-associated protein 1; Protein that interacts with Vps4p and has a role in vacuolar sorting; stimulates the ATPase activity of Vps4; localizes to endosomes in a Vps4-dependent manner; overexpression causes canavanine sensitivity and confers a partial class D vacuole morphology.


ensembl_gene_id: YER129W
symbol: SAK1
gene_biotype: protein_coding
description:
  Upstream serine/threonine kinase for the SNF1 complex; plays a role in pseudohyphal groth; partially redundant with Elm1p and Tos3p; members of this family have functional orthology with LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome; SAK1 has a paralog, TOS3, that arose from the whole genome duplication.


ensembl_gene_id: YER130C
symbol: COM2
gene_biotype: protein_coding
description:
  Zinc finger protein YER130C; Transcription factor that binds IME1 Upstream Activation Signal (UAS)ru; COM2 transcription is regulated by Haa1p, Sok2p and Zap1p transcriptional activators; may bind the IME1 promoter under all growth conditions to negatively regulate its transcription in the absence of a positive regulator that binds more effectively; repressor activity may depend on phosphorylation by PKA; C. albicans homolog (MNL1) plays a role in adaptation to stress.


ensembl_gene_id: YER131W
symbol: RPS26B
gene_biotype: protein_coding
description:
  Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S26, no bacterial homolog; RPS26B has a paralog, RPS26A, that arose from the whole genome duplication; human homolog can partially complement an RPS26A, RPS26B double null mutant; mutations in the human gene are associated with Diamond-Blackfan anemia.


ensembl_gene_id: YER132C
symbol: PMD1
gene_biotype: protein_coding
description:
  Protein with an N-terminal kelch-like domain; putative negative regulator of early meiotic gene expression; required, with Mds3p, for growth under alkaline conditions; PMD1 has a paralog, MDS3, that arose from the whole genome duplication.


ensembl_gene_id: YER133W
symbol: GLC7
gene_biotype: protein_coding
description:
  Serine/threonine-protein phosphatase PP1-2; Type 1 S/T protein phosphatase (PP1) catalytic subunit; involved in glycogen metabolism, sporulation and mitotic progression; interacts with multiple regulatory subunits; regulates actomyosin ring formation; subunit of CPF; recruited to mating projections by Afr1p interaction; regulates nucleocytoplasmic shuttling of Hxk2p; import into the nucleus is inhibited during spindle assembly checkpoint arrest; involved in dephosphorylating Rps6a/b and Bnr1p.


ensembl_gene_id: YER133W-A
symbol: YER133W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YER133W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps ORF YER134C.


ensembl_gene_id: YER134C
symbol: YER134C
gene_biotype: protein_coding
description:
  Magnesium-dependent acid phosphatase; member of the haloacid dehalogenase superfamily; non-essential gene; Belongs to the HAD-like hydrolase superfamily.


ensembl_gene_id: YER135C
symbol: YER135C
gene_biotype: protein_coding
description:
  Uncharacterized protein YER135C; Putative protein of unknown function; conserved among S. cerevisiae strains; YER135C is not an essential gene.


ensembl_gene_id: YER136W
symbol: GDI1
gene_biotype: protein_coding
description:
  Rab GDP-dissociation inhibitor; GDP dissociation inhibitor; regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins.


ensembl_gene_id: YER137W-A
symbol: YER137W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YER137W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF YER137C.


ensembl_gene_id: YER138W-A
symbol: YER138W-A
gene_biotype: protein_coding
description:
  Putative protein of unknown function; YER138W-A has a paralog, YBL107W-A, that arose from a single-locus duplication.


ensembl_gene_id: YER139C
symbol: RTR1
gene_biotype: protein_coding
description:
  RNA polymerase II subunit B1 CTD phosphatase RTR1; CTD phosphatase; dephosphorylates S5-P in the C-terminal domain of Rpo21p; has a cysteine-rich motif required for function and conserved in eukaryotes; shuttles between the nucleus and cytoplasm; RTR1 has a paralog, RTR2, that arose from the whole genome duplication; Belongs to the RPAP2 family.


ensembl_gene_id: YER140W
symbol: EMP65
gene_biotype: protein_coding
description:
  Endoplasmic reticulum membrane protein 65; Integral membrane protein of the ER; forms an ER-membrane associated protein complex with Slp1p; identified along with SLP1 in a screen for mutants defective in the unfolded protein response (UPR); proposed to function in the folding of integral membrane proteins; interacts genetically with MPS3; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Belongs to the TAPT1 family.


ensembl_gene_id: YER141W
symbol: COX15
gene_biotype: protein_coding
description:
  Cytochrome c oxidase assembly protein COX15; Protein required for the hydroxylation of heme O to form heme A; heme A is an essential prosthetic group for cytochrome c oxidase; Belongs to the COX15/CtaA family.


ensembl_gene_id: YER142C
symbol: MAG1
gene_biotype: protein_coding
description:
  3-methyl-adenine DNA glycosylase; involved in protecting DNA against alkylating agents; initiates base excision repair by removing damaged bases to create abasic sites that are subsequently repaired; protein abundance increases in response to DNA replication stress; Belongs to the alkylbase DNA glycosidase AlkA family.


ensembl_gene_id: YER143W
symbol: DDI1
gene_biotype: protein_coding
description:
  DNA damage-inducible v-SNARE binding protein; role in suppression of protein secretion; may play a role in S-phase checkpoint control; has ubiquitin-associated (UBA), ubiquitin-like (UBL), and retroviral-like proteinase (RVP) domains.


ensembl_gene_id: YER144C
symbol: UBP5
gene_biotype: protein_coding
description:
  Putative ubiquitin-specific protease; concentrates at the bud neck; UBP5 has a paralog, DOA4, that arose from the whole genome duplication; Belongs to the peptidase C19 family.


ensembl_gene_id: YER145C
symbol: FTR1
gene_biotype: protein_coding
description:
  High affinity iron permease; involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by iron; protein abundance increases in response to DNA replication stress; Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.


ensembl_gene_id: YER145C-A
symbol: YER145C-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YER145C-A; Putative protein of unknown function; conserved among S. cerevisiae strains; overlaps verified ORF LSM5/YER146W.


ensembl_gene_id: YER146W
symbol: LSM5
gene_biotype: protein_coding
description:
  U6 snRNA-associated Sm-like protein LSm5; Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA.


ensembl_gene_id: YER147C
symbol: SCC4
gene_biotype: protein_coding
description:
  MAU2 chromatid cohesion factor homolog; Subunit of cohesin loading factor (Scc2p-Scc4p); complex is required for the loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during double-strand break repair via phosphorylated histone H2AX.


ensembl_gene_id: YER147C-A
symbol: YER147C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized membrane protein YER147C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF SPT15/YER148W.


ensembl_gene_id: YER148W
symbol: SPT15
gene_biotype: protein_coding
description:
  TATA-binding protein (TBP); general transcription factor that interacts with other factors to form the preinitiation complex at promoters; essential for viability, highly conserved; yeast gene can complement mutations in human homolog TBP.


ensembl_gene_id: YER148W-A
symbol: YER148W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized membrane protein YER148W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF PEA2/YER149C.


ensembl_gene_id: YER149C
symbol: PEA2
gene_biotype: protein_coding
description:
  Protein PEA2; Coiled-coil 12S polarisome subunit; required for polarity establishment, apical bud growth, shmoo formation, filamentous differentiation; involved in Bni1p localization at sites of polarized growth, controlling polarized assembly of actin cables; role in apical growth affects diploid-specific bipolar bud site selection; retains Slt2p at bud tip to regulate ER inheritance; role in Ca2+ influx, cell fusion; S288C allele encoding Leu409 rather than Met linked with non-invasion.


ensembl_gene_id: YER150W
symbol: SPI1
gene_biotype: protein_coding
description:
  GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; SPI1 has a paralog, SED1, that arose from the whole genome duplication; Belongs to the SED1 family.


ensembl_gene_id: YER151C
symbol: UBP3
gene_biotype: protein_coding
description:
  Ubiquitin carboxyl-terminal hydrolase 3; Ubiquitin-specific protease involved in transport and osmotic response; negatively regulates Ras/PKA signaling; interacts with Bre5p to coregulate anterograde, retrograde transport between ER and Golgi; involved in transcription elongation in response to osmostress through phosphorylation at Ser695 by Hog1p; inhibitor of gene silencing; role in ribophagy; cleaves ubiquitin fusions but not polyubiquitin; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YER152C
symbol: YER152C
gene_biotype: protein_coding
description:
  Uncharacterized protein YER152C; Protein with 2-aminoadipate transaminase activity; shares amino acid similarity with the aminotransferases Aro8p and Aro9p; YER152C is not an essential gene.


ensembl_gene_id: YER152W-A
symbol: YER152W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YER152W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF YER152C.


ensembl_gene_id: YER153C
symbol: PET122
gene_biotype: protein_coding
description:
  Protein PET122, mitochondrial; Mitochondrial translational activator specific for the COX3 mRNA; acts together with Pet54p and Pet494p; located in the mitochondrial inner membrane.


ensembl_gene_id: YER154W
symbol: OXA1
gene_biotype: protein_coding
description:
  Mitochondrial inner membrane insertase; mediates the insertion of both mitochondrial- and nuclear-encoded proteins from the matrix into the inner membrane; also has a role in insertion of carrier proteins into the inner membrane; acts as a voltage-gated ion channel, activated by substrate peptides; interacts with mitochondrial ribosomes; conserved from bacteria to animals.


ensembl_gene_id: YER155C
symbol: BEM2
gene_biotype: protein_coding
description:
  GTPase-activating protein BEM2/IPL2; Rho GTPase activating protein (RhoGAP); involved in the control of cytoskeleton organization and cellular morphogenesis; required for bud emergence; potential GAP for Rho4p.


ensembl_gene_id: YER156C
symbol: YER156C
gene_biotype: protein_coding
description:
  UPF0160 protein YER156C; Putative protein of unknown function; interacts with Hsp82p and copurifies with Ipl1p; expression is copper responsive and downregulated in strains deleted for MAC1, a copper-responsive transcription factor; similarity to mammalian MYG1.


ensembl_gene_id: YER157W
symbol: COG3
gene_biotype: protein_coding
description:
  Essential component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments.


ensembl_gene_id: YER158C
symbol: YER158C
gene_biotype: protein_coding
description:
  Uncharacterized protein YER158C; Protein of unknown function; potentially phosphorylated by Cdc28p; YER158C has a paralog, AFR1, that arose from the whole genome duplication.


ensembl_gene_id: YER158W-A
symbol: YER158W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YER158W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching.


ensembl_gene_id: YER159C
symbol: BUR6
gene_biotype: protein_coding
description:
  Subunit of a heterodimeric NC2 transcription regulator complex; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha; complex also includes Ncb2p; bur6 ncb2 double mutation is functionally complemented by coexpression of human DRAP1 and DR1, although the single bur6 mutation is not complemented by its ortholog DRAP1.


ensembl_gene_id: YER161C
symbol: SPT2
gene_biotype: protein_coding
description:
  Protein involved in negative regulation of transcription; required for RNA polyadenylation; exhibits regulated interactions with both histones and SWI-SNF components; relocalizes to the cytosol in response to hypoxia; similar to mammalian HMG1 proteins.


ensembl_gene_id: YER162C
symbol: RAD4
gene_biotype: protein_coding
description:
  Protein that recognizes and binds damaged DNA (with Rad23p) during NER; subunit of Nuclear Excision Repair Factor 2 (NEF2); also involved, with Rad23p, in turnover of ubiquitylated proteins; Rad4p-Rad23p heterodimer binds to promoters of DNA damage response genes to repress their transcription in the absence of DNA damage; NER stands for nucleotide excision repair; Belongs to the XPC family.


ensembl_gene_id: YER163C
symbol: GCG1
gene_biotype: protein_coding
description:
  Glutathione-specific gamma-glutamylcyclotransferase; Gamma-glutamyl cyclotransferase; cleaves the gamma-glutamyl bond of glutathione to yield 5-oxoproline and a Cys-Gly dipeptide; similar to mammalian pro-apoptotic protein ChaC1; expression of mouse ChaC1 in yeast increases apoptosis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; periodically expressed during the metabolic cycle.


ensembl_gene_id: YER164W
symbol: CHD1
gene_biotype: protein_coding
description:
  Chromo domain-containing protein 1; Chromatin remodeler that regulates various aspects of transcription; acts in in conjunction with Isw1b to regulate chromatin structure and maintain chromatin integrity during transcription elongation by RNAP II by preventing trans-histone exchange over coding regions; contains a chromo domain, a helicase domain and a DNA-binding domain; component of both the SAGA and SLIK complexes.


ensembl_gene_id: YER165C-A
symbol: YER165C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized membrane protein YER165C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene DNF1/YER166W.


ensembl_gene_id: YER165W
symbol: PAB1
gene_biotype: protein_coding
description:
  Polyadenylate-binding protein, cytoplasmic and nuclear; Poly(A) binding protein; part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G; stimulates, but is not required for the deadenylation activity of the Pan2p-Pan3p poly(A)-ribonuclease complex; Belongs to the polyadenylate-binding protein type-1 family.


ensembl_gene_id: YER166W
symbol: DNF1
gene_biotype: protein_coding
description:
  Phospholipid-transporting ATPase DNF1; Aminophospholipid translocase (flippase); type 4 P-type ATPase; involved in phospholipid translocation, contributing to endocytosis, protein transport, and cellular polarization; localizes primarily to the plasma membrane; localizes to the shmoo tip where it has a redundant role in the cellular response to mating pheromone; DNF1 has a paralog, DNF2, that arose from the whole genome duplication.


ensembl_gene_id: YER167W
symbol: BCK2
gene_biotype: protein_coding
description:
  Protein BCK2; Serine/threonine-rich protein involved in PKC1 signaling pathway; protein kinase C (PKC1) signaling pathway controls cell integrity; overproduction suppresses pkc1 mutations.


ensembl_gene_id: YER168C
symbol: CCA1
gene_biotype: protein_coding
description:
  CCA tRNA nucleotidyltransferase, mitochondrial; ATP (CTP):tRNA-specific tRNA nucleotidyltransferase; different forms targeted to the nucleus, cytosol, and mitochondrion are generated via the use of multiple transcriptional and translational start sites; human homolog TRNT1 complements yeast null mutant.


ensembl_gene_id: YER169W
symbol: RPH1
gene_biotype: protein_coding
description:
  DNA damage-responsive transcriptional repressor RPH1; JmjC domain-containing histone demethylase; targets tri- and dimethylated H3K36; associates with actively transcribed regions and promotes elongation; repressor of autophagy-related genes in nutrient-replete conditions; damage-responsive repressor of PHR1; phosphorylated by the Rad53p-dependent DNA damage checkpoint pathway and by a Rim1p-mediated event during starvation; target of stress-induced hormesis; RPH1 has a paralog, GIS1, that arose from the whole genome duplication.


ensembl_gene_id: YER170W
symbol: ADK2
gene_biotype: protein_coding
description:
  GTP:AMP phosphotransferase, mitochondrial; Mitochondrial adenylate kinase; catalyzes the reversible synthesis of GTP and AMP from GDP and ADP; may serve as a back-up for synthesizing GTP or ADP depending on metabolic conditions; 3' sequence of ADK2 varies with strain background.


ensembl_gene_id: YER171W
symbol: RAD3
gene_biotype: protein_coding
description:
  5' to 3' DNA helicase; involved in nucleotide excision repair and transcription; subunit of RNA polII initiation factor TFIIH and of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPD protein; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress; Belongs to the helicase family. RAD3/XPD subfamily.


ensembl_gene_id: YER172C
symbol: BRR2
gene_biotype: protein_coding
description:
  Pre-mRNA-splicing helicase BRR2; RNA-dependent ATPase RNA helicase (DEIH box); required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis; homologous to human U5-200kD.


ensembl_gene_id: YER172C-A
symbol: YER172C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YER172C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF RAD24/YER173W.


ensembl_gene_id: YER173W
symbol: RAD24
gene_biotype: protein_coding
description:
  Checkpoint protein; involved in the activation of the DNA damage and meiotic pachytene checkpoints; subunit of a clamp loader that loads Rad17p-Mec3p-Ddc1p onto DNA; homolog of human and S. pombe Rad17 protein.


ensembl_gene_id: YER174C
symbol: GRX4
gene_biotype: protein_coding
description:
  Monothiol glutaredoxin-4; Glutathione-dependent oxidoreductase; hydroperoxide and superoxide-radical responsive; monothiol glutaredoxin subfamily member along with Grx3p and Grx5p; protects cells from oxidative damage; with Grx3p, binds to Aft1p in iron-replete conditions, promoting its dissociation from promoters; mutant has increased aneuploidy tolerance; transcription regulated by Yap5p; GRX4 has a paralog, GRX3, that arose from the whole genome duplication.


ensembl_gene_id: YER175C
symbol: TMT1
gene_biotype: protein_coding
description:
  Trans-aconitate methyltransferase; cytosolic enzyme that catalyzes the methyl esterification of 3-isopropylmalate, an intermediate of the leucine biosynthetic pathway, and trans-aconitate, which inhibits the citric acid cycle; Belongs to the methyltransferase superfamily. Tam family.


ensembl_gene_id: YER175W-A
symbol: YER175W-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YER175W-A; Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching.


ensembl_gene_id: YER176W
symbol: ECM32
gene_biotype: protein_coding
description:
  Putative ATP-dependent RNA helicase ECM32; DNA dependent ATPase/DNA helicase; helicase belonging to the Dna2p- and Nam7p-like family of helicases that is involved in modulating translation termination; interacts with the translation termination factors, localized to polysomes.


ensembl_gene_id: YER177W
symbol: BMH1
gene_biotype: protein_coding
description:
  14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of exocytosis, vesicle transport, Ras/MAPK and rapamycin-sensitive signaling, aggresome formation, spindle position checkpoint; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; antiapoptotic gene similar to human 14-3-3; BMH1 has a paralog, BMH2, that arose from whole genome duplication.


ensembl_gene_id: YER178W
symbol: PDA1
gene_biotype: protein_coding
description:
  E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex; catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA; phosphorylated; regulated by glucose; PDH complex is concentrated in spots within the mitochondrial matrix, often near the ERMES complex and near peroxisomes.


ensembl_gene_id: YER179W
symbol: DMC1
gene_biotype: protein_coding
description:
  Meiotic recombination protein DMC1; Meiosis-specific recombinase required for double-strand break repair; also required for pairing between homologous chromosomes; required for the normal morphogenesis of synaptonemal complex; homolog of Rad51p and the bacterial RecA protein; binds ssDNA and dsDNA, forms helical filaments; stimulated by Rdh54p.


ensembl_gene_id: YER180C
symbol: ISC10
gene_biotype: protein_coding
description:
  Meiosis-specific protein ISC10; Protein required for sporulation; transcript is induced 7.5 hours after induction of meiosis, expected to play significant role in the formation of reproductive cells.


ensembl_gene_id: YER180C-A
symbol: SLO1
gene_biotype: protein_coding
description:
  SCOCO-like protein 1; Protein interacting with Arl3p; Arl3p is a GTPase of the Ras superfamily involved in vesicle-tethering at the Golgi; putative ortholog of human SCOCO.


ensembl_gene_id: YER181C
symbol: YER181C
gene_biotype: protein_coding
description:
  Mitochondrial protein of unknown function; conserved among S. cerevisiae strains; extensively overlaps a Ty1 LTR; YER181C is not an essential gene.


ensembl_gene_id: YER182W
symbol: FMP10
gene_biotype: protein_coding
description:
  Uncharacterized mitochondrial membrane protein FMP10; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Belongs to the FMP10 family.


ensembl_gene_id: YER183C
symbol: FAU1
gene_biotype: protein_coding
description:
  5-formyltetrahydrofolate cyclo-ligase; 5,10-methenyltetrahydrofolate synthetase; involved in folic acid biosynthesis.


ensembl_gene_id: YER184C
symbol: TOG1
gene_biotype: protein_coding
description:
  Transcription factor TOG1; Transcriptional activator of oleate genes; regulates genes involved in fatty acid utilization; zinc cluster protein; deletion confers sensitivity to Calcufluor white, and prevents growth on glycerol or lactate as sole carbon source.


ensembl_gene_id: YER185W
symbol: PUG1
gene_biotype: protein_coding
description:
  Protoporphyrin uptake protein 1; Plasma membrane protein involved in protoprophyrin and heme transport; roles in the uptake of protoprophyrin IX and the efflux of heme; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of proteins.


ensembl_gene_id: YER187W
symbol: YER187W
gene_biotype: protein_coding
description:
  Uncharacterized protein YER187W; Putative protein of unknown function; induced in respiratory-deficient cells; To yeast killer toxin KHS and to YGL262w.


ensembl_gene_id: YER188W
symbol: YER188W
gene_biotype: protein_coding
description:
  Uncharacterized protein YER188W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; large-scale analyses show mRNA expression increases under anaerobic conditions and two-hybrid interactions with Sst2p.


ensembl_gene_id: YER190C-A
symbol: YER190C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YER190C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF YRF1-2/YER190W; identified by gene-trapping, expression analysis, and homology.


ensembl_gene_id: YER190C-B
symbol: YER190C-B
gene_biotype: protein_coding
description:
  UPF0479 membrane protein YEL077W-A; Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching.


ensembl_gene_id: YER190W
symbol: YRF1-2
gene_biotype: protein_coding
description:
  Y' element ATP-dependent helicase protein 1 copy 2; Helicase encoded by the Y' element of subtelomeric regions; highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p; induced by treatment with 8-methoxypsoralen and UVA irradiation.


ensembl_gene_id: YFL001W
symbol: DEG1
gene_biotype: protein_coding
description:
  tRNA:pseudouridine synthase; introduces pseudouridines at position 38 or 39 in tRNA; also responsible for pseudouracil modification of some mRNAs; important for maintenance of translation efficiency and normal cell growth, localizes to both the nucleus and cytoplasm; non-essential for viability.


ensembl_gene_id: YFL002C
symbol: SPB4
gene_biotype: protein_coding
description:
  Putative ATP-dependent RNA helicase; nucleolar protein required for synthesis of 60S ribosomal subunits at a late step in the pathway; sediments with 66S pre-ribosomes in sucrose gradients; Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.


ensembl_gene_id: YFL003C
symbol: MSH4
gene_biotype: protein_coding
description:
  MutS protein homolog 4; Protein involved in meiotic recombination; required for normal levels of crossing over, colocalizes with Zip2p to discrete foci on meiotic chromosomes, has homology to bacterial MutS protein; Belongs to the DNA mismatch repair MutS family.


ensembl_gene_id: YFL004W
symbol: VTC2
gene_biotype: protein_coding
description:
  Regulatory subunit of the vacuolar transporter chaperone (VTC) complex; involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion; VTC2 has a paralog, VTC3, that arose from the whole genome duplication; Belongs to the VTC2/3 family.


ensembl_gene_id: YFL005W
symbol: SEC4
gene_biotype: protein_coding
description:
  Ras-related protein SEC4; Rab family GTPase; essential for vesicle-mediated exocytic secretion and autophagy; associates with the exocyst component Sec15p and may regulate polarized delivery of transport vesicles to the exocyst at the plasma membrane.


ensembl_gene_id: YFL007W
symbol: BLM10
gene_biotype: protein_coding
description:
  Proteasome activator; binds the core proteasome (CP) and stimulates proteasome-mediated protein degradation by inducing gate opening; required for sequestering CP into proteasome storage granule (PSG) during quiescent phase and for nuclear import of CP in proliferating cells; required for resistance to bleomycin, may be involved in protecting against oxidative damage; similar to mammalian PA200.


ensembl_gene_id: YFL008W
symbol: SMC1
gene_biotype: protein_coding
description:
  Structural maintenance of chromosomes protein 1; Subunit of the multiprotein cohesin complex; essential protein involved in chromosome segregation and in double-strand DNA break repair; SMC chromosomal ATPase family member, binds DNA with a preference for DNA with secondary structure; Belongs to the SMC family. SMC1 subfamily.


ensembl_gene_id: YFL009W
symbol: CDC4
gene_biotype: protein_coding
description:
  Cell division control protein 4; F-box protein required for both the G1/S and G2/M phase transitions; modular substrate specificity factor which associates with core SCF (Cdc53p, Skp1p and Hrt1p/Rbx1p) to form the SCFCdc4 complex; SCFCdc4 acts as a ubiquitin-protein ligase directing ubiquitination of cyclin-dependent kinase (CDK) phosphorylated substrates, such as: Sic1p, Far1p, Cdc6p, Clb6p, and Cln3p.


ensembl_gene_id: YFL010C
symbol: WWM1
gene_biotype: protein_coding
description:
  WW domain containing protein of unknown function; binds to Mca1p, a caspase-related protease that regulates H2O2-induced apoptosis; overexpression causes G1 phase growth arrest and clonal death that is suppressed by overexpression of MCA1.


ensembl_gene_id: YFL010W-A
symbol: AUA1
gene_biotype: protein_coding
description:
  Protein required for the negative regulation by ammonia of Gap1p; Gap1p is a general amino acid permease.


ensembl_gene_id: YFL012W
symbol: YFL012W
gene_biotype: protein_coding
description:
  Uncharacterized protein YFL012W; Putative protein of unknown function; transcribed during sporulation; null mutant exhibits increased resistance to rapamycin.


ensembl_gene_id: YFL012W-A
symbol: YFL012W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YFL012W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene IES1/YFL013C.


ensembl_gene_id: YFL013C
symbol: IES1
gene_biotype: protein_coding
description:
  Subunit of the INO80 chromatin remodeling complex; relocalizes to the cytosol in response to hypoxia.


ensembl_gene_id: YFL013W-A
symbol: YFL013W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YFL013W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps IES1/YFL013C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching.


ensembl_gene_id: YFL014W
symbol: HSP12
gene_biotype: protein_coding
description:
  12 kDa heat shock protein; Plasma membrane protein involved in maintaining membrane organization; involved in maintaining organization during stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension.


ensembl_gene_id: YFL015C
symbol: YFL015C
gene_biotype: protein_coding
description:
  Uncharacterized protein YFL015C; Putative protein of unknown function; conserved across S. cerevisiae strains; partially overlaps dubious ORF YFL015W-A; YFL015C is not an essential gene.


ensembl_gene_id: YFL015W-A
symbol: YFL015W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized membrane protein YFL015W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF YFL015C.


ensembl_gene_id: YFL016C
symbol: MDJ1
gene_biotype: protein_coding
description:
  DnaJ homolog 1, mitochondrial; Co-chaperone that stimulates HSP70 protein Ssc1p ATPase activity; involved in protein folding/refolding in the mitochodrial matrix; required for proteolysis of misfolded proteins; member of the HSP40 (DnaJ) family of chaperones.


ensembl_gene_id: YFL017C
symbol: GNA1
gene_biotype: protein_coding
description:
  Glucosamine-6-phosphate acetyltransferase; evolutionarily conserved; required for multiple cell cycle events including passage through START, DNA synthesis, and mitosis; involved in UDP-N-acetylglucosamine synthesis, forms GlcNAc6P from AcCoA; Belongs to the acetyltransferase family. GNA1 subfamily.


ensembl_gene_id: YFL017W-A
symbol: SMX2
gene_biotype: protein_coding
description:
  Small nuclear ribonucleoprotein G; Core Sm protein Sm G; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx3p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm G.


ensembl_gene_id: YFL018C
symbol: LPD1
gene_biotype: protein_coding
description:
  Dihydrolipoyl dehydrogenase, mitochondrial; Dihydrolipoamide dehydrogenase; the lipoamide dehydrogenase component (E3) of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multi-enzyme complexes; PDH complex is concentrated in spots within the mitochondrial matrix, often near the ERMES complex and near peroxisomes; LPD1 has a paralog, IRC15, that arose from the whole genome duplication; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.


ensembl_gene_id: YFL019C
symbol: YFL019C
gene_biotype: protein_coding
description:
  Uncharacterized protein YFL019C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; YFL019C is not an essential gene.


ensembl_gene_id: YFL020C
symbol: PAU5
gene_biotype: protein_coding
description:
  Seripauperin-5; Member of the seripauperin multigene family; encoded mainly in subtelomeric regions; induced during alcoholic fermentation; induced by low temperature and also by anaerobic conditions; negatively regulated by oxygen and repressed by heme.


ensembl_gene_id: YFL021C-A
symbol: YFL021C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized membrane protein YFL021C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF GAT1/YFL021W.


ensembl_gene_id: YFL021W
symbol: GAT1
gene_biotype: protein_coding
description:
  Transcriptional regulatory protein GAT1; Transcriptional activator of nitrogen catabolite repression genes; contains a GATA-1-type zinc finger DNA-binding motif; activity and localization regulated by nitrogen limitation and Ure2p; different translational starts produce two major and two minor isoforms that are differentially regulated and localized.


ensembl_gene_id: YFL022C
symbol: FRS2
gene_biotype: protein_coding
description:
  Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase; forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.


ensembl_gene_id: YFL023W
symbol: BUD27
gene_biotype: protein_coding
description:
  Bud site selection protein 27; Unconventional prefoldin protein involved in translation initiation; required for correct assembly of RNAP I, II, and III in an Rpb5p-dependent manner; shuttles between nucleus and cytoplasm; mutants have inappropriate expression of nutrient sensitive genes due to translational derepression of Gcn4p transcription factor; diploid mutants show random budding; ortholog of human URI/RMP.


ensembl_gene_id: YFL024C
symbol: EPL1
gene_biotype: protein_coding
description:
  Enhancer of polycomb-like protein 1; Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex; conserved region at N-terminus is essential for interaction with the NPC (nucleosome core particle); required for autophagy; homologous to Drosophila Enhancer of Polycomb; coding sequence contains length polymorphisms in different strains.


ensembl_gene_id: YFL025C
symbol: BST1
gene_biotype: protein_coding
description:
  GPI inositol deacylase of the endoplasmic reticulum (ER); negatively regulates COPII vesicle formation; prevents production of vesicles with defective subunits; required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules; functional ortholog of human PGAP1, mutation of which is associated with intellectual disability and encephalopathy.


ensembl_gene_id: YFL026W
symbol: STE2
gene_biotype: protein_coding
description:
  Receptor for alpha-factor pheromone; seven transmembrane-domain GPCR that interacts with both pheromone and a heterotrimeric G protein to initiate the signaling response that leads to mating between haploid a and alpha cells; Belongs to the G-protein coupled receptor 4 family.


ensembl_gene_id: YFL027C
symbol: GYP8
gene_biotype: protein_coding
description:
  GTPase-activating protein for yeast Rab family members; Ypt1p is the preferred in vitro substrate but also acts on Sec4p, Ypt31p and Ypt32p; involved in the regulation of ER to Golgi vesicle transport.


ensembl_gene_id: YFL028C
symbol: CAF16
gene_biotype: protein_coding
description:
  CCR4-associated factor 16; Part of evolutionarily-conserved CCR4-NOT regulatory complex; contains single ABC-type ATPase domain but no transmembrane domain; interacts with several subunits of Mediator; Belongs to the ABC transporter superfamily.


ensembl_gene_id: YFL029C
symbol: CAK1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase CAK1; Cyclin-dependent kinase-activating kinase; required for passage through the cell cycle; phosphorylates and activates Cdc28p; nucleotide-binding pocket differs significantly from those of most other protein kinases.


ensembl_gene_id: YFL030W
symbol: AGX1
gene_biotype: protein_coding
description:
  Alanine--glyoxylate aminotransferase 1; Alanine:glyoxylate aminotransferase (AGT); catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; similar to mammalian and plant alanine:glyoxylate aminotransferases; human homolog AGXT complements yeast null mutant; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.


ensembl_gene_id: YFL031C-A
symbol: YFL031C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YFL031C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps HAC1/YFL031W; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching.


ensembl_gene_id: YFL031W
symbol: HAC1
gene_biotype: protein_coding
description:
  Transcriptional activator HAC1; Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog); regulates the unfolded protein response, via UPRE binding, and membrane biogenesis; ER stress-induced splicing pathway facilitates efficient Hac1p synthesis; two functional forms of Hac1p are produced; translation initiation is repressed under non-stress conditions; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YFL032W
symbol: YFL032W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YFL032W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HAC1/YFL031W; YFL032W is not an essential gene.


ensembl_gene_id: YFL033C
symbol: RIM15
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase RIM15; Protein kinase involved in cell proliferation in response to nutrients; glucose-repressible; involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; phosphorylates Igo1p and Igo2p; substrate of Pho80p-Pho85p kinase.


ensembl_gene_id: YFL034C-A
symbol: RPL22B
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L22A; required for translation of long 5' UTR of IME1 mRNA and meiotic entry; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22B has a paralog, RPL22A, that arose from the whole genome duplication.


ensembl_gene_id: YFL034C-B
symbol: MOB2
gene_biotype: protein_coding
description:
  Activator of Cbk1p kinase; component of the RAM signaling network that regulates cellular polarity and morphogenesis; activation of Cbk1p facilitates the Ace2p-dependent daughter cell-specific transcription of genes involved in cell separation; similar to Mob1p.


ensembl_gene_id: YFL034W
symbol: MIL1
gene_biotype: protein_coding
description:
  Probable lipase MIL1; Predicted lipase; binds variant medium clathrin chain Apm2p and contributes to its membrane recruitment; putative integral membrane protein that interacts with Rpp0p component of ribosomal stalk; Belongs to the TMCO4 family.


ensembl_gene_id: YFL036W
symbol: RPO41
gene_biotype: protein_coding
description:
  Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation; Rpo41p also synthesizes RNA primers for mitochondrial DNA replication.


ensembl_gene_id: YFL037W
symbol: TUB2
gene_biotype: protein_coding
description:
  Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria.


ensembl_gene_id: YFL038C
symbol: YPT1
gene_biotype: protein_coding
description:
  GTP-binding protein YPT1; Rab family GTPase; involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by type II protein geranylgeranyltransferase (Bet2p-Bet4p); binds to unspliced HAC1 mRNA; regulates the unfolded protein response (UPR) by promoting the decay of HAC1 RNA; localizes to the early Golgi, the transitional Golgi and ER membranes, pre-autophagosomal structures, and cytoplasmic vesicles.


ensembl_gene_id: YFL039C
symbol: ACT1
gene_biotype: protein_coding
description:
  Actin; structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions.


ensembl_gene_id: YFL040W
symbol: YFL040W
gene_biotype: protein_coding
description:
  Probable metabolite transport protein YFL040W; Putative transporter; member of the sugar porter family; YFL040W is not an essential gene; may have a role in intracellular sterol transport.


ensembl_gene_id: YFL041W
symbol: FET5
gene_biotype: protein_coding
description:
  Iron transport multicopper oxidase FET5; Multicopper oxidase; integral membrane protein with similarity to Fet3p; may have a role in iron transport.


ensembl_gene_id: YFL041W-A
symbol: YFL041W-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YFL041W-A; Putative protein of unknown function; identified by fungal homology and RT-PCR.


ensembl_gene_id: YFL042C
symbol: LAM5
gene_biotype: protein_coding
description:
  Membrane-anchored lipid-binding protein LAM5; Putative sterol transfer protein; one of six StART-like domain-containing proteins in yeast that may be involved in sterol transfer between intracellular membranes; conserved across eukaryotes; has both GRAM and StART-like (VASt) domains; localizes to membrane contact sites throughout the cell, including nucleus-vacuole junctions and ER-mitochondrial contact sites.


ensembl_gene_id: YFL044C
symbol: OTU1
gene_biotype: protein_coding
description:
  Ubiquitin thioesterase OTU1; Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p; may contribute to regulation of protein degradation by deubiquitylating substrates that have been ubiquitylated by Ufd2p; member of the Ovarian Tumor (OTU) family; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YFL045C
symbol: SEC53
gene_biotype: protein_coding
description:
  Phosphomannomutase; involved in synthesis of GDP-mannose and dolichol-phosphate-mannose; required for folding and glycosylation of secretory proteins in the ER lumen; Belongs to the eukaryotic PMM family.


ensembl_gene_id: YFL046W
symbol: FMP32
gene_biotype: protein_coding
description:
  Protein FMP32, mitochondrial; Putative assembly factor for cytochrome c oxidase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; has similarity to human MCUR1/CCDC90A.


ensembl_gene_id: YFL047W
symbol: RGD2
gene_biotype: protein_coding
description:
  Rho-GTPase-activating protein RGD2; GTPase-activating protein (RhoGAP) for Cdc42p and Rho5p; relocalizes from bud neck to cytoplasm upon DNA replication stress.


ensembl_gene_id: YFL048C
symbol: EMP47
gene_biotype: protein_coding
description:
  Protein EMP47; Integral membrane component of ER-derived COPII-coated vesicles; functionS in ER to Golgi transport; EMP47 has a paralog, EMP46, that arose from the whole genome duplication; Belongs to the EMP46/EMP47 family.


ensembl_gene_id: YFL049W
symbol: SWP82
gene_biotype: protein_coding
description:
  SWI/SNF global transcription activator complex subunit SWP82; Member of the SWI/SNF chromatin remodeling complex; has an as yet unidentified role in the complex; has identifiable counterparts in closely related yeast species; abundantly expressed in many growth conditions; paralog of Npl6p; relocates to the cytosol under hypoxic conditions; Belongs to the RSC7/SWP82 family. SWP82 subfamily.


ensembl_gene_id: YFL050C
symbol: ALR2
gene_biotype: protein_coding
description:
  Magnesium transporter ALR2; Probable Mg(2+) transporter; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions; plays a role in regulating Ty1 transposition.


ensembl_gene_id: YFL051C
symbol: YFL051C
gene_biotype: protein_coding
description:
  Uncharacterized membrane protein YFL051C; Putative protein of unknown function; SWAT-GFP fusion protein localizes to the cell periphery while mCherry fusion protein localizes to both the cell periphery and vacuole; YFL051C is not an essential gene.


ensembl_gene_id: YFL052W
symbol: ZNF1
gene_biotype: protein_coding
description:
  Zinc cluster transcription factor that regulates respiratory growth; binds to promoters of genes involved in respiration, gluconeogenesis, and the glyoxylate shunt; required for normal carbon source utilization and stress response; Belongs to the MAL13 family.


ensembl_gene_id: YFL053W
symbol: DAK2
gene_biotype: protein_coding
description:
  Dihydroxyacetone kinase; required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation; Belongs to the dihydroxyacetone kinase (DAK) family.


ensembl_gene_id: YFL054C
symbol: AQY3
gene_biotype: protein_coding
description:
  Aquaglycerol porin AQY3; Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol.


ensembl_gene_id: YFL055W
symbol: AGP3
gene_biotype: protein_coding
description:
  Low-affinity amino acid permease; may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation; plays a role in regulating Ty1 transposition; Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.


ensembl_gene_id: YFL058W
symbol: THI5
gene_biotype: protein_coding
description:
  4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase THI5; Protein involved in synthesis of the thiamine precursor HMP; member of a subtelomeric gene family including THI5, THI11, THI12, and THI13; hydroxymethylpyrimidine is also known as HMP; Belongs to the NMT1/THI5 family.


ensembl_gene_id: YFL059W
symbol: SNZ3
gene_biotype: protein_coding
description:
  Probable pyridoxal 5'-phosphate synthase subunit SNZ3; Member of a stationary phase-induced gene family; expressed in the presence of galactose; transcription of SNZ3 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO3.


ensembl_gene_id: YFL060C
symbol: SNO3
gene_biotype: protein_coding
description:
  Probable pyridoxal 5'-phosphate synthase subunit SNO3; Protein of unknown function; nearly identical to Sno2p; expression is induced before the diauxic shift and also in the absence of thiamin.


ensembl_gene_id: YFL061W
symbol: DDI2
gene_biotype: protein_coding
description:
  Cyanamide hydratase that detoxifies cyanamide; member of the HD domain metalloprotein superfamily; expression is induced over 100-fold by cyanamide and by SN2-type DNA alkylating agents such as MMS and DMA; induction decreased in rad6 and rad18 mutants; gene and protein are identical to DDI3 and Ddi3p.


ensembl_gene_id: YFL063W
symbol: YFL063W
gene_biotype: protein_coding
description:
  Putative UPF0320 protein YFL063W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YFL065C
symbol: YFL065C
gene_biotype: protein_coding
description:
  Uncharacterized protein YFL065C; Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation.


ensembl_gene_id: YFL066C
symbol: YFL066C
gene_biotype: protein_coding
description:
  Helicase-like protein encoded within the telomeric Y' element; induced by treatment with 8-methoxypsoralen and UVA irradiation; SWAT-GFP and mCherry fusion proteins localize to the nucleus.


ensembl_gene_id: YFL067W
symbol: YFL067W
gene_biotype: protein_coding
description:
  Uncharacterized membrane protein YFL067W; Protein of unknown function; down-regulated at low calcium levels; mCherry fusion protein localizes to the vacuole.


ensembl_gene_id: YFL068W
symbol: YFL068W
gene_biotype: protein_coding
description:
  UPF0479 membrane protein YFL068W; Putative protein of unknown function; SWAT-GFP and mCherry fusion proteins localize to the cytosol.


ensembl_gene_id: YFR001W
symbol: LOC1
gene_biotype: protein_coding
description:
  60S ribosomal subunit assembly/export protein LOC1; Nuclear protein involved in asymmetric localization of ASH1 mRNA; binds double-stranded RNA in vitro; constituent of 66S pre-ribosomal particles; required at post-transcriptional step for efficient retrotransposition; absence results in decreased Ty1 Gag:GFP protein levels; relocalizes from nucleus to cytoplasm upon DNA replication stress.


ensembl_gene_id: YFR002W
symbol: NIC96
gene_biotype: protein_coding
description:
  Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins (Nsp1p, Nup57p, and Nup49p).


ensembl_gene_id: YFR003C
symbol: YPI1
gene_biotype: protein_coding
description:
  Regulatory subunit of the type I protein phosphatase (PP1) Glc7p; Glc7p participates in the regulation of a variety of metabolic processes including mitosis and glycogen metabolism; in vitro evidence suggests Ypi1p is an inhibitor of Glc7p while in vivo evidence suggests it is an activator; overproduction causes decreased cellular content of glycogen; partial depletion causes lithium sensitivity, while overproduction confers lithium-tolerance.


ensembl_gene_id: YFR004W
symbol: RPN11
gene_biotype: protein_coding
description:
  Ubiquitin carboxyl-terminal hydrolase RPN11; Metalloprotease subunit of 19S regulatory particle; part of 26S proteasome lid; couples the deubiquitination and degradation of proteasome substrates; involved, independent of catalytic activity, in fission of mitochondria and peroxisomes; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YFR005C
symbol: SAD1
gene_biotype: protein_coding
description:
  Pre-mRNA-splicing factor SAD1; Conserved zinc-finger domain protein involved in pre-mRNA splicing; critical for splicing of nearly all intron-containing genes; required for assembly of U4 snRNA into the U4/U6 particle.


ensembl_gene_id: YFR006W
symbol: YFR006W
gene_biotype: protein_coding
description:
  Uncharacterized peptidase YFR006W; Putative X-Pro aminopeptidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YFR006W is not an essential gene.


ensembl_gene_id: YFR007W
symbol: YFH7
gene_biotype: protein_coding
description:
  ATP-dependent kinase YFH7; Putative kinase with similarity to the PRK/URK/PANK kinase subfamily; the PRK/URK/PANK subfamily of P-loop kinases is also known as phosphoribulokinase/uridine kinase/bacterial pantothenate kinase; Belongs to the YFH7 family.


ensembl_gene_id: YFR008W
symbol: FAR7
gene_biotype: protein_coding
description:
  Factor arrest protein 7; Protein involved in recovery from pheromone-induced cell cycle arrest; acts in a Far1p-independent pathway; interacts with Far3p, Far8p, Far9p, Far10p, and Far11p; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YFR009W
symbol: GCN20
gene_biotype: protein_coding
description:
  Protein GCN20; Positive regulator of the Gcn2p kinase activity; forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA; Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.


ensembl_gene_id: YFR009W-A
symbol: YFR009W-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YFR009W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YFR009W; identified by expression profiling and mass spectrometry.


ensembl_gene_id: YFR010W
symbol: UBP6
gene_biotype: protein_coding
description:
  Ubiquitin-specific protease; situated in the base subcomplex of the 26S proteasome, releases free ubiquitin from branched polyubiquitin chains en bloc, rather than from the distal tip of the chain; negatively regulates degradation of ubiquitinated proteins by the proteasome; works in opposition to Hul5p polyubiquitin elongation activity; mutant has aneuploidy tolerance; human homolog UBP14 complements yeast null mutant.


ensembl_gene_id: YFR010W-A
symbol: YFR010W-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YFR010W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the uncharacterized gene YFR011C; identified by expression profiling and mass spectrometry.


ensembl_gene_id: YFR011C
symbol: MIC19
gene_biotype: protein_coding
description:
  Component of the MICOS complex; MICOS (formerly MINOS or MitOS) is a mitochondrial inner membrane complex that extends into the intermembrane space and has a role in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane; Mic19p is peripheral to the inner membrane and may connect Mic60p with the Mic10p-Mic12p-Mic27p subcomplex; both yeast and human Mic19p become oxidized, and oxidation may regulate MICOS.


ensembl_gene_id: YFR012W
symbol: DCV1
gene_biotype: protein_coding
description:
  Protein of unknown function; deletion mutant shows strong genetic interaction with cdc28-as1 mutant in the presence of 1-NM-PP1; DCV1 has a paralog, YOL019W, that arose from the whole genome duplication.


ensembl_gene_id: YFR013W
symbol: IOC3
gene_biotype: protein_coding
description:
  ISWI one complex protein 3; Subunit of the Isw1a complex; Isw1a has nucleosome-stimulated ATPase activity and represses transcription initiation by specific positioning of a promoter proximal dinucleosome; promotes nucleosome shifts in the 5 prime direction; IOC3 has a paralog, ESC8, that arose from the whole genome duplication.


ensembl_gene_id: YFR014C
symbol: CMK1
gene_biotype: protein_coding
description:
  Calmodulin-dependent protein kinase; may play a role in stress response, many Ca++/calmodulin dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK1 has a paralog, CMK2, that arose from the whole genome duplication.


ensembl_gene_id: YFR015C
symbol: GSY1
gene_biotype: protein_coding
description:
  Glycogen [starch] synthase isoform 1; Glycogen synthase; expression induced by glucose limitation, nitrogen starvation, environmental stress, and entry into stationary phase; GSY1 has a paralog, GSY2, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress; Belongs to the glycosyltransferase 3 family.


ensembl_gene_id: YFR016C
symbol: YFR016C
gene_biotype: protein_coding
description:
  Uncharacterized protein YFR016C; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and bud; interacts with Spa2p; YFR016C is not an essential gene.


ensembl_gene_id: YFR017C
symbol: IGD1
gene_biotype: protein_coding
description:
  Cytoplasmic protein that inhibits Gdb1p glycogen debranching activity; required for normal intracellular accumulation of glycogen; phosphorylated in vivo; expression increases during wine fermentation; protein abundance increases in response to DNA replication stress; IGD1 has a paralog, YOL024W, that arose from the whole genome duplication.


ensembl_gene_id: YFR018C
symbol: YFR018C
gene_biotype: protein_coding
description:
  Uncharacterized protein YFR018C; Putative protein of unknown function; SWAT-GFP and seamless GFP fusion proteins localize to the endoplasmic reticulum and mCherry fusion protein localizes to the vacuole.


ensembl_gene_id: YFR019W
symbol: FAB1
gene_biotype: protein_coding
description:
  1-phosphatidylinositol-3-phosphate 5-kinase; vacuolar membrane kinase that generates phosphatidylinositol (3,5)P2, which is involved in vacuolar sorting and homeostasis.


ensembl_gene_id: YFR020W
symbol: CSS2
gene_biotype: protein_coding
description:
  Protein of unknown function, secreted when constitutively expressed; SWAT-GFP fusion protein localizes to the endoplasmic reticulum (ER) and extracellular region, while mCherry fusion protein localizes to the ER and vacuole; mRNA identified as translated by ribosome profiling data; CSS2 is a non-essential gene.


ensembl_gene_id: YFR021W
symbol: ATG18
gene_biotype: protein_coding
description:
  Autophagy-related protein 18; Phosphoinositide binding protein; required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein; relocalizes from vacuole to cytoplasm upon DNA replication stress; has 4 mammalian homologs WIPI1, WIPI2, WIPI3 and WIPI4/WDR45; mutations in human WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood.


ensembl_gene_id: YFR022W
symbol: ROG3
gene_biotype: protein_coding
description:
  Protein ROG3; Alpha-arrestin involved in ubiquitin-dependent endocytosis; contributes to desensitization of agonist-occupied alpha-factor receptor Ste2p by Rsp5p-independent internalization; PPXY motif-mediated binding of the ubiquitin ligase Rsp5p is not required for adaptation; mutation suppresses the temperature sensitivity of an mck1 rim11 double mutant; SWAT-GFP and mCherry fusion proteins localize to the cytosol; ROG3 has a paralog, ROD1, that arose from the whole genome duplication.


ensembl_gene_id: YFR023W
symbol: PES4
gene_biotype: protein_coding
description:
  Poly(A) binding protein, suppressor of DNA polymerase epsilon mutation; PES4 has a paralog, MIP6, that arose from the whole genome duplication.


ensembl_gene_id: YFR024C-A
symbol: LSB3
gene_biotype: protein_coding
description:
  Protein containing a C-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein abundance increases in response to DNA replication stress; LSB3 has a paralog, YSC84, that arose from the whole genome duplication.


ensembl_gene_id: YFR025C
symbol: HIS2
gene_biotype: protein_coding
description:
  Histidinol-phosphatase; Histidinolphosphatase; catalyzes the eighth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control.


ensembl_gene_id: YFR026C
symbol: ULI1
gene_biotype: protein_coding
description:
  Protein of unknown function; involved in and induced by the endoplasmic reticulum unfolded protein response (UPR); SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum.


ensembl_gene_id: YFR027W
symbol: ECO1
gene_biotype: protein_coding
description:
  N-acetyltransferase ECO1; Acetyltransferase; required for establishment of sister chromatid cohesion; acetylates Mps3p to regulate nuclear organization; modifies Smc3p at replication forks and Mcd1p in response to dsDNA breaks; phosphorylated by three kinases (Cdc28p, Cdc7p, Mck1p) to generate pair of phosphates spaced precisely for recognition by ubiquitin ligase SCF-Cdc4; mutations in human homolog ESCO2 cause Roberts syndrome; relative distribution to nucleus increases upon DNA replication stress.


ensembl_gene_id: YFR028C
symbol: CDC14
gene_biotype: protein_coding
description:
  Tyrosine-protein phosphatase CDC14; Protein phosphatase required for mitotic exit; required for rDNA segregation, cytokinesis, meiosis I spindle disassembly, environmental stress response; held in nucleolus by Cdc55p in early meiosis, liberated by FEAR and Mitotic Exit Network in anaphase, enabling it to effect a decrease in CDK/B-cyclin activity and mitotic exit; sequestered in metaphase II, released upon entry into anaphase II; human homolog CDC14A can complement thermosensitivity of yeast cdc14-1 mutant.


ensembl_gene_id: YFR029W
symbol: PTR3
gene_biotype: protein_coding
description:
  SPS-sensor component PTR3; Component of the SPS plasma membrane amino acid sensor system; senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes; other members are Ssy1p, Ptr3p, and Ssy5p.


ensembl_gene_id: YFR030W
symbol: MET10
gene_biotype: protein_coding
description:
  Sulfite reductase [NADPH] flavoprotein component; Subunit alpha of assimilatory sulfite reductase; complex converts sulfite into sulfide.


ensembl_gene_id: YFR031C
symbol: SMC2
gene_biotype: protein_coding
description:
  Structural maintenance of chromosomes protein 2; Subunit of the condensin complex; condensin reorganizes chromosomes during both mitosis and meiosis; essential SMC chromosomal ATPase family member that forms a subcomplex with Smc2p that has ATP-hydrolyzing and DNA-binding activity, but other condensin subunits are required for chromatin binding; required for clustering of tRNA genes at the nucleolus.


ensembl_gene_id: YFR031C-A
symbol: RPL2A
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L2A; homologous to mammalian ribosomal protein L2 and bacterial L2; RPL2A has a paralog, RPL2B, that arose from the whole genome duplication.


ensembl_gene_id: YFR032C
symbol: RRT5
gene_biotype: protein_coding
description:
  Regulator of rDNA transcription protein 5; Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; expressed at high levels during sporulation.


ensembl_gene_id: YFR032C-A
symbol: RPL29
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L29; not essential for translation, but required for proper joining of large and small ribosomal subunits and for normal translation rate; homologous to mammalian ribosomal protein L29, no bacterial homolog; Belongs to the eukaryotic ribosomal protein eL29 family.


ensembl_gene_id: YFR032C-B
symbol: YFR032C-B
gene_biotype: protein_coding
description:
  Uncharacterized protein YFR032C-B; Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching.


ensembl_gene_id: YFR033C
symbol: QCR6
gene_biotype: protein_coding
description:
  Subunit 6 of the ubiquinol cytochrome-c reductase complex; the complex, also known as the cytochrome bc(1) complex or Complex III, is a component of the mitochondrial inner membrane electron transport chain; highly acidic protein; required for maturation of cytochrome c1; may be loosely associated with the complex since it is easily released into the intermembrane space; Belongs to the UQCRH/QCR6 family.


ensembl_gene_id: YFR034C
symbol: PHO4
gene_biotype: protein_coding
description:
  Phosphate system positive regulatory protein PHO4; Basic helix-loop-helix (bHLH) transcription factor of the myc-family; activates transcription cooperatively with Pho2p in response to phosphate limitation; binding to 'CACGTG' motif is regulated by chromatin restriction, competitive binding of Cbf1p to the same DNA binding motif and cooperation with Pho2p; function is regulated by phosphorylation at multiple sites and by phosphate availability.


ensembl_gene_id: YFR034W-A
symbol: YFR034W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YFR034W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps YFR035C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching.


ensembl_gene_id: YFR035C
symbol: YFR035C
gene_biotype: protein_coding
description:
  Uncharacterized protein YFR035C; Putative protein of unknown function; deletion mutant exhibits synthetic phenotype with alpha-synuclein.


ensembl_gene_id: YFR036W
symbol: CDC26
gene_biotype: protein_coding
description:
  Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; relocalizes to the cytosol in response to hypoxia; Belongs to the CDC26 family.


ensembl_gene_id: YFR036W-A
symbol: YFR036W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YFR036W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps verified ORF RSC8/YFR037C.


ensembl_gene_id: YFR037C
symbol: RSC8
gene_biotype: protein_coding
description:
  Chromatin structure-remodeling complex protein RSC8; Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters.


ensembl_gene_id: YFR038W
symbol: IRC5
gene_biotype: protein_coding
description:
  Uncharacterized ATP-dependent helicase IRC5; Putative ATPase containing the DEAD/H helicase-related sequence motif; null mutant displays increased levels of spontaneous Rad52p foci; SWAT-GFP and mCherry fusion proteins localize to the nucleus.


ensembl_gene_id: YFR039C
symbol: OSW7
gene_biotype: protein_coding
description:
  Protein involved in outer spore wall assembly; likely involved directly in dityrosine layer assembly; may be involved in response to high salt and changes in carbon source; SWAT-GFP, seamless-GFP and mCherry fusion proteins localize to the endoplasmic reticulum; deletion mutant has decreased spore survival in Drosophila feces; OSW7 has a paralog, SHE10, that arose from the whole genome duplication; paralogs are redundant for spore wall dityrosine assembly.


ensembl_gene_id: YFR040W
symbol: SAP155
gene_biotype: protein_coding
description:
  SIT4-associating protein SAP155; Protein required for function of the Sit4p protein phosphatase; forms a complex with Sit4p; member of a family of similar proteins including Sap4p, Sap185p, and Sap190p; protein abundance increases in response to DNA replication stress; SAP155 has a paralog, SAP4, that arose from the whole genome duplication; Belongs to the SAPS family.


ensembl_gene_id: YFR041C
symbol: ERJ5
gene_biotype: protein_coding
description:
  ER-localized J domain-containing protein 5; Type I membrane protein with a J domain; required to preserve the folding capacity of the endoplasmic reticulum; loss of the non-essential ERJ5 gene leads to a constitutively induced unfolded protein response; Belongs to the DnaJ family.


ensembl_gene_id: YFR042W
symbol: KEG1
gene_biotype: protein_coding
description:
  Beta-1,6-glucan synthesis-associated protein KEG1; Integral membrane protein of the ER; physically interacts with Kre6p; has a role in the synthesis of beta-1,6-glucan in the cell wall; required for cell viability.


ensembl_gene_id: YFR043C
symbol: IRC6
gene_biotype: protein_coding
description:
  Increased recombination centers protein 6; Clathrin coat accessory factor; involved in clathrin-mediated vesicle trafficking; may function to link the AP-1 clathrin adaptor complex with the Rab GTPase Ypt31p; has structural similarity to G-proteins; mouse homolog Aagab (p34) functionally complements irc6 null mutation; null mutant displays increased levels of spontaneous Rad52p foci.


ensembl_gene_id: YFR044C
symbol: DUG1
gene_biotype: protein_coding
description:
  Cys-Gly metallodipeptidase DUG1; Cys-Gly metallo-di-peptidase; forms a complex with Dug2p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p); human homolog CNDP2 can complement yeast dug1 mutant.


ensembl_gene_id: YFR045W
symbol: YFR045W
gene_biotype: protein_coding
description:
  Uncharacterized mitochondrial carrier YFR045W; Putative mitochondrial transport protein; null mutant is viable, exhibits decreased levels of chitin and normal resistance to calcofluor white.


ensembl_gene_id: YFR046C
symbol: CNN1
gene_biotype: protein_coding
description:
  Inner kinetochore subunit CNN1; Kinetochore protein; associated with the essential kinetochore proteins Nnf1p and Spc24p; phosphorylated by Clb5-Cdk1, Mps1p, Ipl1p and to a lesser extent by Clb2-Cdk1; localizes to the lower region of the Ndc80 complex during anaphase and regulates KMN activity by inhibiting the Mtw1 and Spc105 complexes from binding to the Ndc80 complex; similar to metazoan CENP-T; Belongs to the CENP-T/CNN1 family.


ensembl_gene_id: YFR047C
symbol: BNA6
gene_biotype: protein_coding
description:
  Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Quinolinate phosphoribosyl transferase; required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p; Belongs to the NadC/ModD family.


ensembl_gene_id: YFR049W
symbol: YMR31
gene_biotype: protein_coding
description:
  37S ribosomal protein YMR-31, mitochondrial; Subunit of the mitochondrial alpha-ketoglutarate dehydrogenase; recruits E3 subunit (Lpd1p) to the E1-E2 (Kgd1p, Kgd2p) core; has similarity to human mitochondrial ribosomal protein MRP-S36.


ensembl_gene_id: YFR051C
symbol: RET2
gene_biotype: protein_coding
description:
  Delta subunit of the coatomer complex (COPI); COPI coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER; Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.


ensembl_gene_id: YFR052C-A
symbol: YFR052C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YFR052C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps ORF HXK1/YFR053C.


ensembl_gene_id: YFR052W
symbol: RPN12
gene_biotype: protein_coding
description:
  Subunit of the 19S regulatory particle of the 26S proteasome lid; synthetically lethal with RPT1, which is an ATPase component of the 19S regulatory particle; physically interacts with Nob1p and Rpn3p; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YFR053C
symbol: HXK1
gene_biotype: protein_coding
description:
  Hexokinase-1; Hexokinase isoenzyme 1; a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves hexokinase Hxk2p; HXK1 has a paralog, HXK2, that arose from the whole genome duplication.


ensembl_gene_id: YFR054C
symbol: YFR054C
gene_biotype: protein_coding
description:
  Uncharacterized protein YFR054C; Putative protein of unknown function; conserved among S. cerevisiae strains.


ensembl_gene_id: YFR055W
symbol: IRC7
gene_biotype: protein_coding
description:
  Putative cystathionine beta-lyase; Beta-lyase involved in the production of thiols; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner and by copper levels in a Mac1-dependent manner.


ensembl_gene_id: YFR056C
symbol: YFR056C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YFR056C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W.


ensembl_gene_id: YGL001C
symbol: ERG26
gene_biotype: protein_coding
description:
  Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating; C-3 sterol dehydrogenase; catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; human homolog NSDHL implicated in CK syndrome, and can complement yeast null mutant; molecular target of natural product and antifungal compound FR171456.


ensembl_gene_id: YGL002W
symbol: ERP6
gene_biotype: protein_coding
description:
  Protein ERP6; Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; ERP6 has a paralog, ERP1, that arose from the whole genome duplication; Belongs to the EMP24/GP25L family.


ensembl_gene_id: YGL003C
symbol: CDH1
gene_biotype: protein_coding
description:
  Activator of anaphase-promoting complex/cyclosome (APC/C); antagonist of the spindle assembly checkpoint; directs ubiquitination of cyclins resulting in mitotic exit; targets the APC/C to specific substrates including: Cdc20p, Ase1p, Cin8p, Fin1p and Clb5p; partially active in metaphase, and fully active in anaphase; cell-cycle regulated; Belongs to the WD repeat CDC20/Fizzy family.


ensembl_gene_id: YGL004C
symbol: RPN14
gene_biotype: protein_coding
description:
  26S proteasome regulatory subunit RPN14; Evolutionarily conserved 19S regulatory particle assembly-chaperone; proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p.


ensembl_gene_id: YGL005C
symbol: COG7
gene_biotype: protein_coding
description:
  Component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments.


ensembl_gene_id: YGL006W
symbol: PMC1
gene_biotype: protein_coding
description:
  Vacuolar Ca2+ ATPase involved in depleting cytosol of Ca2+ ions; prevents growth inhibition by activation of calcineurin in the presence of elevated concentrations of calcium; similar to mammalian PMCA1a.


ensembl_gene_id: YGL007C-A
symbol: YGL007C-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YGL007C-A; Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; deletion exhibits slow-growth phenotype; computationally predicted to have a role in cell budding.


ensembl_gene_id: YGL007W
symbol: BRP1
gene_biotype: protein_coding
description:
  Uncharacterized protein BRP1; Putative protein of unknown function; conserved among S. cerevisiae strains; located in the upstream region of PMA1; deletion leads to polyamine resistance due to downregulation of PMA1.


ensembl_gene_id: YGL008C
symbol: PMA1
gene_biotype: protein_coding
description:
  Plasma membrane P2-type H+-ATPase; pumps protons out of cell; major regulator of cytoplasmic pH and plasma membrane potential; long-lived protein asymmetrically distributed at plasma membrane between mother cells and buds; accumulates at high levels in mother cells during aging, buds emerge with very low levels of Pma1p, newborn cells have low levels of Pma1p; Hsp30p plays a role in Pma1p regulation; interactions with Std1p appear to propagate [GAR+]; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.


ensembl_gene_id: YGL009C
symbol: LEU1
gene_biotype: protein_coding
description:
  3-isopropylmalate dehydratase; Isopropylmalate isomerase; catalyzes the second step in the leucine biosynthesis pathway; Belongs to the aconitase/IPM isomerase family.


ensembl_gene_id: YGL010W
symbol: MPO1
gene_biotype: protein_coding
description:
  Uncharacterized endoplasmic reticulum membrane protein YGL010W; Protein involved in metabolism of phytosphingosine; not an essential gene.


ensembl_gene_id: YGL011C
symbol: SCL1
gene_biotype: protein_coding
description:
  Alpha 1 subunit of the 20S proteasome; involved in the degradation of ubiquitinated substrates; 20S proteasome is the core complex of the 26S proteasome; essential for growth; detected in the mitochondria; Belongs to the peptidase T1A family.


ensembl_gene_id: YGL012W
symbol: ERG4
gene_biotype: protein_coding
description:
  C-24(28) sterol reductase; catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol; Belongs to the ERG4/ERG24 family.


ensembl_gene_id: YGL013C
symbol: PDR1
gene_biotype: protein_coding
description:
  Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; relocalizes to the cytosol in response to hypoxia; PDR1 has a paralog, PDR3, that arose from the whole genome duplication.


ensembl_gene_id: YGL014C-A
symbol: YGL014C-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YGL014C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by expression profiling and mass spectrometry.


ensembl_gene_id: YGL014W
symbol: PUF4
gene_biotype: protein_coding
description:
  Pumilio homology domain family member 4; Member of the PUF protein family; PUF family is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding nucleolar ribosomal RNA-processing factors.


ensembl_gene_id: YGL015C
symbol: YGL015C
gene_biotype: protein_coding
description:
  Uncharacterized protein YGL015C; Putative protein of unknown function; null mutants accumulate cargo in the Golgi.


ensembl_gene_id: YGL016W
symbol: KAP122
gene_biotype: protein_coding
description:
  Importin beta-like protein KAP122; Karyopherin beta; responsible for import of the Toa1p-Toa2p complex into the nucleus; binds to nucleoporins Nup1p and Nup2p; may play a role in regulation of pleiotropic drug resistance.


ensembl_gene_id: YGL017W
symbol: ATE1
gene_biotype: protein_coding
description:
  Arginyl-tRNA--protein transferase 1; Arginyl-tRNA-protein transferase; catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway; Belongs to the R-transferase family.


ensembl_gene_id: YGL018C
symbol: JAC1
gene_biotype: protein_coding
description:
  J-type co-chaperone JAC1, mitochondrial; Specialized J-protein that functions in Fe-S cluster biogenesis; functions with Hsp70 in Fe-S cluster biogenesis in mitochondria; involved in iron metabolism; contains a J domain typical to J-type chaperones; localizes to the mitochondrial matrix.


ensembl_gene_id: YGL019W
symbol: CKB1
gene_biotype: protein_coding
description:
  Beta regulatory subunit of casein kinase 2 (CK2); a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases.


ensembl_gene_id: YGL020C
symbol: GET1
gene_biotype: protein_coding
description:
  Golgi to ER traffic protein 1; Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for normal mitochondrial morphology and inheritance.


ensembl_gene_id: YGL021W
symbol: ALK1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase Haspin homolog ALK1; Protein kinase; along with its paralog, ALK2, required for proper spindle positioning and nuclear segregation following mitotic arrest, proper organization of cell polarity factors in mitosis, proper localization of formins and polarity factors, and survival in cells that activate spindle assembly checkpoint; phosphorylated in response to DNA damage; ALK1 has a paralog, ALK2, that arose from the whole genome duplication; similar to mammalian haspins.


ensembl_gene_id: YGL022W
symbol: STT3
gene_biotype: protein_coding
description:
  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3; Subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes asparagine-linked glycosylation of newly synthesized proteins; forms a subcomplex with Ost3p and Ost4p and is directly involved in catalysis; Belongs to the STT3 family.


ensembl_gene_id: YGL024W
symbol: YGL024W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YGL024W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF PGD1/YGL025C.


ensembl_gene_id: YGL025C
symbol: PGD1
gene_biotype: protein_coding
description:
  Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for basal and activated transcription; direct target of Cyc8p-Tup1p transcriptional corepressor.


ensembl_gene_id: YGL026C
symbol: TRP5
gene_biotype: protein_coding
description:
  Tryptophan synthase; catalyzes the last step of tryptophan biosynthesis; regulated by the general control system of amino acid biosynthesis; In the N-terminal section; belongs to the TrpA family.


ensembl_gene_id: YGL027C
symbol: CWH41
gene_biotype: protein_coding
description:
  Processing alpha glucosidase I; ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress; Belongs to the glycosyl hydrolase 63 family.


ensembl_gene_id: YGL028C
symbol: SCW11
gene_biotype: protein_coding
description:
  Probable family 17 glucosidase SCW11; Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on its regulation by Ste12p.


ensembl_gene_id: YGL029W
symbol: CGR1
gene_biotype: protein_coding
description:
  rRNA-processing protein CGR1; Protein involved in nucleolar integrity and processing of pre-rRNA; has a role in processing rRNA for the 60S ribosome subunit; transcript is induced in response to cytotoxic stress but not genotoxic stress; relocalizes from nucleus to nucleolus upon DNA replication stress.


ensembl_gene_id: YGL030W
symbol: RPL30
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L30; involved in pre-rRNA processing in the nucleolus; autoregulates splicing of its transcript; homologous to mammalian ribosomal protein L30, no bacterial homolog.


ensembl_gene_id: YGL031C
symbol: RPL24A
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L24A; not essential for translation but may be required for normal translation rate; homologous to mammalian ribosomal protein L24, no bacterial homolog; RPL24A has a paralog, RPL24B, that arose from the whole genome duplication.


ensembl_gene_id: YGL032C
symbol: AGA2
gene_biotype: protein_coding
description:
  Adhesion subunit of a-agglutinin of a-cells; C-terminal sequence acts as a ligand for alpha-agglutinin (Sag1p) during agglutination, modified with O-linked oligomannosyl chains, linked to anchorage subunit Aga1p via two disulfide bonds.


ensembl_gene_id: YGL033W
symbol: HOP2
gene_biotype: protein_coding
description:
  Homologous-pairing protein 2; Meiosis-specific protein that localizes to chromosomes; prevents synapsis between nonhomologous chromosomes and ensures synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair; heterodimer of Hop2p-Mnd1p stimulates the Dmc1p-mediated strand invasion.


ensembl_gene_id: YGL034C
symbol: YGL034C
gene_biotype: protein_coding
description:
  Uncharacterized protein YGL034C; Putative protein of unknown function; conserved among S. cerevisiae strains; YGL034C is not an essential gene.


ensembl_gene_id: YGL035C
symbol: MIG1
gene_biotype: protein_coding
description:
  Regulatory protein MIG1; Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase; regulates filamentous growth along with Mig2p in response to glucose depletion; activated in stochastic pulses of nuclear localization, shuttling between cytosol and nucleus depending on external glucose levels and its phosphorylation state; Belongs to the creA/MIG C2H2-type zinc-finger protein family.


ensembl_gene_id: YGL036W
symbol: YGL036W
gene_biotype: protein_coding
description:
  Uncharacterized protein YGL036W; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YGL036W is not an essential gene.


ensembl_gene_id: YGL037C
symbol: PNC1
gene_biotype: protein_coding
description:
  Nicotinamidase that converts nicotinamide to nicotinic acid; part of the NAD(+) salvage pathway; required for life span extension by calorie restriction; lacks a peroxisomal targeting signal but is imported into peroxisomes via binding to Gpd1p; PNC1 expression responds to all known stimuli that extend replicative life span; protein increases in abundance and relative distribution to cytoplasmic foci decreases upon DNA replication stress.


ensembl_gene_id: YGL038C
symbol: OCH1
gene_biotype: protein_coding
description:
  Initiation-specific alpha-1,6-mannosyltransferase; Mannosyltransferase of the cis-Golgi apparatus; initiates the polymannose outer chain elongation of N-linked oligosaccharides of glycoproteins; Belongs to the glycosyltransferase 32 family.


ensembl_gene_id: YGL039W
symbol: YGL039W
gene_biotype: protein_coding
description:
  Putative uncharacterized oxidoreductase YGL039W; Aldehyde reductase; reduces aliphatic aldehyde substrates using NADH as cofactor; shown to reduce carbonyl compounds to chiral alcohols.


ensembl_gene_id: YGL040C
symbol: HEM2
gene_biotype: protein_coding
description:
  Delta-aminolevulinic acid dehydratase; Aminolevulinate dehydratase; a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus; human homolog ALAD can complement yeast hem2 mutant.


ensembl_gene_id: YGL041C
symbol: YGL041C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YGL041C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YGL041C-B
symbol: YGL041C-B
gene_biotype: protein_coding
description:
  Uncharacterized protein YGL041C-B; Putative protein of unknown function; identified by fungal homology and RT-PCR; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum.


ensembl_gene_id: YGL041W-A
symbol: YGL041W-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YGL041W-A, mitochondrial; Putative protein of unknown function; conserved in fungi; identified by expression profiling and mass spectrometry.


ensembl_gene_id: YGL042C
symbol: YGL042C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YGL042C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene DST1.


ensembl_gene_id: YGL043W
symbol: DST1
gene_biotype: protein_coding
description:
  General transcription elongation factor TFIIS; enables RNA polymerase II to read through blocks to elongation by stimulating cleavage of nascent transcripts stalled at transcription arrest sites; maintains RNAPII elongation activity on ribosomal protein genes during conditions of transcriptional stress; Belongs to the TFS-II family.


ensembl_gene_id: YGL044C
symbol: RNA15
gene_biotype: protein_coding
description:
  mRNA 3'-end-processing protein RNA15; Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; interacts with the A-rich polyadenylation signal in complex with Rna14p and Hrp1p; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; required for gene looping and maintenance of genome stability.


ensembl_gene_id: YGL045W
symbol: RIM8
gene_biotype: protein_coding
description:
  pH-response regulator protein palF/RIM8; Protein involved in proteolytic activation of Rim101p; part of response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family.


ensembl_gene_id: YGL047W
symbol: ALG13
gene_biotype: protein_coding
description:
  UDP-N-acetylglucosamine transferase subunit ALG13; Catalytic component of UDP-GlcNAc transferase; required for the second step of dolichyl-linked oligosaccharide synthesis; anchored to the ER membrane via interaction with Alg14p; similar to bacterial and human glycosyltransferases; protein abundance increases in response to DNA replication stress; both human homologs ALG13 and ALG14 are required to complement yeast alg13 mutant.


ensembl_gene_id: YGL048C
symbol: RPT6
gene_biotype: protein_coding
description:
  ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; bound by ubiquitin-protein ligases Ubr1p and Ufd4p; localized mainly to the nucleus throughout the cell cycle; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YGL049C
symbol: TIF4632
gene_biotype: protein_coding
description:
  Translation initiation factor eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); associates with the poly(A)-binding protein Pab1p, also interacts with eIF4A (Tif1p); TIF4632 has a paralog, TIF4631, that arose from the whole genome duplication.


ensembl_gene_id: YGL050W
symbol: TYW3
gene_biotype: protein_coding
description:
  tRNA wybutosine-synthesizing protein 3; tRNA methyltransferase required for synthesis of wybutosine; a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions; Belongs to the TYW3 family.


ensembl_gene_id: YGL051W
symbol: MST27
gene_biotype: protein_coding
description:
  Multicopy suppressor of SEC21 protein 27; Putative integral membrane protein, involved in vesicle formation; forms complex with Mst28p; member of DUP240 gene family; binds COPI and COPII vesicles; MST27 has a paralog, MST28, that arose from a segmental duplication.


ensembl_gene_id: YGL052W
symbol: YGL052W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YGL052W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MST27.


ensembl_gene_id: YGL053W
symbol: PRM8
gene_biotype: protein_coding
description:
  Pheromone-regulated protein; contains with 2 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; forms a complex with Prp9p in the ER; member of DUP240 gene family; PRM8 has a paralog, PRM9, that arose from a segmental duplication.


ensembl_gene_id: YGL054C
symbol: ERV14
gene_biotype: protein_coding
description:
  ER-derived vesicles protein ERV14; COPII-coated vesicle protein; involved in vesicle formation and incorporation of specific secretory cargo; required for the delivery of bud-site selection protein Axl2p and Nha1p antiporter to cell surface; related to Drosophila cornichon; ERV14 has a paralog, ERV15, that arose from the whole genome duplication.


ensembl_gene_id: YGL055W
symbol: OLE1
gene_biotype: protein_coding
description:
  Acyl-CoA desaturase 1; Delta(9) fatty acid desaturase; required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria.


ensembl_gene_id: YGL056C
symbol: SDS23
gene_biotype: protein_coding
description:
  Protein involved in cell separation during budding; one of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; SDS23 has a paralog, SDS24, that arose from the whole genome duplication.


ensembl_gene_id: YGL057C
symbol: GEP7
gene_biotype: protein_coding
description:
  Genetic interactor of prohibitin 7, mitochondrial; Protein of unknown function; null mutant exhibits a respiratory growth defect and synthetic interactions with prohibitin (phb1) and gem1; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Belongs to the GEP7 family.


ensembl_gene_id: YGL058W
symbol: RAD6
gene_biotype: protein_coding
description:
  Ubiquitin-conjugating enzyme (E2); involved in postreplication repair as a heterodimer with Rad18p, regulation of K63 polyubiquitination in response to oxidative stress, DSBR and checkpoint control as a heterodimer with Bre1p, ubiquitin-mediated N-end rule protein degradation as a heterodimer with Ubr1p, ERAD with Ubr1p in the absence of canonical ER membrane ligases, and Rpn4p turnover as part of proteasome homeostasis, in complex with Ubr2p and Mub1p.


ensembl_gene_id: YGL059W
symbol: PKP2
gene_biotype: protein_coding
description:
  Mitochondrial protein kinase; negatively regulates activity of the pyruvate dehydrogenase complex by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp1p and phosphatases Ptc5p and Ptc6p; relocalizes from mitochondrion to cytoplasm upon DNA replication stress.


ensembl_gene_id: YGL060W
symbol: YBP2
gene_biotype: protein_coding
description:
  YAP1-binding protein 2; Central kinetochore associated protein; mediates mitotic progression; interacts with several central kinetochore proteins and centromeric histone Cse4p; role in resistance to oxidative stress; similar to Slk19p; YBP2 has a paralog, YBP1, that arose from the whole genome duplication.


ensembl_gene_id: YGL061C
symbol: DUO1
gene_biotype: protein_coding
description:
  Essential subunit of the Dam1 complex (aka DASH complex); cooperates with Dam1p to connect the DASH complex with microtubules (MT); couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis.


ensembl_gene_id: YGL062W
symbol: PYC1
gene_biotype: protein_coding
description:
  Pyruvate carboxylase isoform; cytoplasmic enzyme that converts pyruvate to oxaloacetate; differentially regulated than isoform Pyc2p; mutations in the human homolog are associated with lactic acidosis; PYC1 has a paralog, PYC2, that arose from the whole genome duplication.


ensembl_gene_id: YGL063C-A
symbol: YGL063C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YGL063C-A; Dubious open reading frame unlikely to encode a functional protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching.


ensembl_gene_id: YGL063W
symbol: PUS2
gene_biotype: protein_coding
description:
  Mitochondrial tRNA:pseudouridine synthase; acts at positions 27 and 28, but not at position 72; efficiently and rapidly targeted to mitochondria, specifically dedicated to mitochondrial tRNA modification; mutation also affects pseudouridylation of some nuclear-encoded mRNAs; PUS2 has a paralog, PUS1, that arose from the whole genome duplication.


ensembl_gene_id: YGL064C
symbol: MRH4
gene_biotype: protein_coding
description:
  Mitochondrial ATP-dependent RNA helicase of the DEAD-box family; required for assembly of the large subunit of mitochondrial ribosomes; binds to the large subunit rRNA, 21S_rRNA; localizes to the matrix face of the mitochondrial inner membrane and associates with the large subunit precursor and with mature ribosomes.


ensembl_gene_id: YGL065C
symbol: ALG2
gene_biotype: protein_coding
description:
  Alpha-1,3/1,6-mannosyltransferase ALG2; Mannosyltransferase in the N-linked glycosylation pathway; catalyzes two consecutive steps in the N-linked glycosylation pathway; alg2 mutants exhibit temperature-sensitive growth and abnormal accumulation of the lipid-linked oligosaccharide Man2GlcNAc2-PP-Dol; human ALG2 complements the temperature sensitivity and dolichol-linked oligosaccharide biosynthesis defect of the alg2-1 mutant, but mutant form from a patient with CDG-Ii fails to complement; Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.


ensembl_gene_id: YGL066W
symbol: SGF73
gene_biotype: protein_coding
description:
  SAGA-associated factor 73; Subunit of DUBm module of SAGA and SLIK; has roles in anchoring deubiquitination module (DUBm) into SAGA and SLIK complexes, maintaining organization and ubiquitin-binding conformation of Ubp8p, thereby contributing to overall DUBm activity; involved in preinitiation complex assembly at promoters; relocalizes to cytosol under hypoxia; human homolog ATXN7 implicated in spinocerebellar ataxia, and can complement yeast null mutant.


ensembl_gene_id: YGL067W
symbol: NPY1
gene_biotype: protein_coding
description:
  NADH diphosphatase (pyrophosphatase); hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes; nudix hydrolase family member.


ensembl_gene_id: YGL068W
symbol: MNP1
gene_biotype: protein_coding
description:
  Mitochondrial ribosomal protein of the large subunit; has similarity to E. coli L7/L12 and human MRPL7 ribosomal proteins; associates with the mitochondrial nucleoid; required for normal respiratory growth.


ensembl_gene_id: YGL069C
symbol: YGL069C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YGL069C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; 92% of ORF overlaps the uncharacterized ORF YGL068W; deletion in cyr1 mutant results in loss of stress resistance.


ensembl_gene_id: YGL070C
symbol: RPB9
gene_biotype: protein_coding
description:
  RNA polymerase II subunit B12.6; contacts DNA; mutations affect transcription start site selection and fidelity of transcription.


ensembl_gene_id: YGL071W
symbol: AFT1
gene_biotype: protein_coding
description:
  Iron-regulated transcriptional activator AFT1; Transcription factor involved in iron utilization and homeostasis; binds consensus site PyPuCACCCPu and activates transcription in response to changes in iron availability; in iron-replete conditions localization is regulated by Grx3p, Grx4p, and Fra2p, and promoter binding is negatively regulated via Grx3p-Grx4p binding; AFT1 has a paralog, AFT2, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress.


ensembl_gene_id: YGL072C
symbol: YGL072C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YGL072C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HSF1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2.


ensembl_gene_id: YGL073W
symbol: HSF1
gene_biotype: protein_coding
description:
  Trimeric heat shock transcription factor; activates multiple genes in response to highly diverse stresses; recognizes variable heat shock elements (HSEs) consisting of inverted NGAAN repeats; monitors translational status of cell through an RQC (Ribosomal Quality Control)-mediated translation-stress signal; involved in diauxic shift; posttranslationally regulated; human homolog HSF1 with linker region mutations can complement yeast hsf1 mutant; Belongs to the HSF family.


ensembl_gene_id: YGL074C
symbol: YGL074C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YGL074C; Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential HSF1 gene encoding heat shock transcription factor.


ensembl_gene_id: YGL075C
symbol: MPS2
gene_biotype: protein_coding
description:
  Monopolar spindle protein 2; Essential membrane protein localized at nuclear envelope and SPBs; required for insertion of the newly duplicated spindle pole body into the nuclear envelope; potentially phosphorylated by Cdc28p; MPS2 has a paralog, CSM4, that arose from the whole genome duplication.


ensembl_gene_id: YGL076C
symbol: RPL7A
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L7A; required for processing of 27SA3 pre-rRNA to 27SB pre-rRNA during assembly of large ribosomal subunit; depletion leads to a turnover of pre-rRNA; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2); binds to Domain II of 25S and 5.8S rRNAs; homologous to mammalian ribosomal protein L7 and bacterial L30; RPL7A has a paralog, RPL7B, that arose from the whole genome duplication.


ensembl_gene_id: YGL077C
symbol: HNM1
gene_biotype: protein_coding
description:
  Plasma membrane transporter for choline, ethanolamine, and carnitine; involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress; co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol.


ensembl_gene_id: YGL078C
symbol: DBP3
gene_biotype: protein_coding
description:
  ATP-dependent RNA helicase DBP3; RNA-Dependent ATPase, member of DExD/H-box family; involved in cleavage of site A3 within the ITS1 spacer during rRNA processing; not essential for growth, but deletion causes severe slow-growth phenotype.


ensembl_gene_id: YGL079W
symbol: KXD1
gene_biotype: protein_coding
description:
  Subunit of the BLOC-1 complex involved in endosomal maturation; null mutant is sensitive to drug inducing secretion of vacuolar cargo; GFP-fusion protein localizes to the endosome; Belongs to the KXD1 family.


ensembl_gene_id: YGL080W
symbol: MPC1
gene_biotype: protein_coding
description:
  Highly conserved subunit of mitochondrial pyruvate carrier (MPC); MPC is a mitochondrial inner membrane complex that mediates pyruvate uptake and comprises Mpc1p and Mpc2p during fermentative growth, or Mcp1p and Mpc3p during respiratory growth; null mutant displays slow growth that is complemented by expression of human or mouse ortholog; mutation in human ortholog MPC1 is associated with lactic acidosis and hyperpyruvatemia.


ensembl_gene_id: YGL081W
symbol: YGL081W
gene_biotype: protein_coding
description:
  Uncharacterized protein YGL081W; Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis.


ensembl_gene_id: YGL082W
symbol: YGL082W
gene_biotype: protein_coding
description:
  Uncharacterized protein YGL082W; Putative protein of unknown function; predicted prenylation/proteolysis target of Afc1p and Rce1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; not an essential gene; YGL082W has a paralog, YPL191C, that arose from the whole genome duplication.


ensembl_gene_id: YGL083W
symbol: SCY1
gene_biotype: protein_coding
description:
  Protein kinase-like protein SCY1; Putative kinase; suppressor of GTPase mutant; similar to bovine rhodopsin kinase; may have a role in intracellular sterol transport.


ensembl_gene_id: YGL084C
symbol: GUP1
gene_biotype: protein_coding
description:
  Glycerol uptake protein 1; Plasma membrane protein involved in remodeling GPI anchors; member of the MBOAT family of putative membrane-bound O-acyltransferases; role in misfolded protein quality control; proposed to be involved in glycerol transport; homolog of the mammalian Hedgehog pathway modulator HHATL; GUP1 has a paralog, GUP2, that arose from the whole genome duplication.


ensembl_gene_id: YGL085W
symbol: LCL3
gene_biotype: protein_coding
description:
  Probable endonuclease LCL3; Putative protein of unknown function; mutant has long chronological lifespan; has homology to Staphylococcus aureus nuclease; GFP-fusion protein localizes to mitochondria; is induced in response to the DNA-damaging agent MMS.


ensembl_gene_id: YGL086W
symbol: MAD1
gene_biotype: protein_coding
description:
  Coiled-coil protein involved in spindle-assembly checkpoint; required for inhibition of karyopherin/importin Pse1p (aka Kap121p) upon spindle assembly checkpoint arrest; phosphorylated by Mps1p upon checkpoint activation which leads to inhibition of anaphase promoting complex activity; forms a complex with Mad2p; gene dosage imbalance between MAD1 and MAD2 leads to chromosome instability; Belongs to the MAD1 family.


ensembl_gene_id: YGL087C
symbol: MMS2
gene_biotype: protein_coding
description:
  Ubiquitin-conjugating enzyme variant; involved in error-free postreplication repair; forms a heteromeric complex with Ubc13p, an active ubiquitin-conjugating enzyme; cooperates with chromatin-associated RING finger proteins, Rad18p and Rad5p; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YGL088W
symbol: YGL088W
gene_biotype: protein_coding
description:
  Uncharacterized protein YGL088W; Putative protein of unknown function; conserved across S. cerevisiae strains; partially overlaps snR10, a snoRNA required for preRNA processing.


ensembl_gene_id: YGL089C
symbol: MF(ALPHA)2
gene_biotype: protein_coding
description:
  Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)1, which is more highly expressed; binds copper(II) ions.


ensembl_gene_id: YGL090W
symbol: LIF1
gene_biotype: protein_coding
description:
  Ligase-interacting factor 1; Component of the DNA ligase IV complex; this complex mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein.


ensembl_gene_id: YGL091C
symbol: NBP35
gene_biotype: protein_coding
description:
  Cytosolic Fe-S cluster assembly factor NBP35; Essential cytoplasmic iron-sulfur cluster binding protein; forms a complex with Cfd1p that is involved in iron-sulfur protein assembly in the cytosol; similar to P-loop NTPases.


ensembl_gene_id: YGL092W
symbol: NUP145
gene_biotype: protein_coding
description:
  Nucleoporin NUP145C; Essential protein with distinct roles in two nuclear pore subcomplexes; catalyzes its own proteolytic cleavage in vivo to generate a C-terminal fragment that is a structural component of the Nup84p subcomplex (with roles in NPC biogenesis and localization of genes to the nuclear periphery), and an N-terminal fragment that is one of several FG-nucleoporins within the NPC central core directly responsible for nucleocytoplasmic transport; homologous to human NUP98.


ensembl_gene_id: YGL093W
symbol: SPC105
gene_biotype: protein_coding
description:
  Spindle pole body component SPC105; Subunit of a kinetochore-microtubule binding complex; complex bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components; complex also includes Kre28p; modified by sumoylation.


ensembl_gene_id: YGL094C
symbol: PAN2
gene_biotype: protein_coding
description:
  Catalytic subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex; complex acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes; Belongs to the peptidase C19 family. PAN2 subfamily.


ensembl_gene_id: YGL095C
symbol: VPS45
gene_biotype: protein_coding
description:
  Protein of the Sec1p/Munc-18 family; essential for vacuolar protein sorting; required for the function of Pep12p and the early endosome/late Golgi SNARE Tlg2p; essential for fusion of Golgi-derived vesicles with the prevacuolar compartment.


ensembl_gene_id: YGL096W
symbol: TOS8
gene_biotype: protein_coding
description:
  Homeobox protein TOS8; Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication.


ensembl_gene_id: YGL097W
symbol: SRM1
gene_biotype: protein_coding
description:
  Nucleotide exchange factor for Gsp1p; localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p; human homolog of the RAN GEF, RCC1, can complement a temperature sensitive point mutant.


ensembl_gene_id: YGL098W
symbol: USE1
gene_biotype: protein_coding
description:
  Essential SNARE protein localized to the ER; involved in retrograde traffic from the Golgi to the ER and Sey1p-independent homotypic ER fusion; required for efficient nuclear fusion during mating; forms a complex with the SNAREs Sec22p, Sec20p and Ufe1p.


ensembl_gene_id: YGL099W
symbol: LSG1
gene_biotype: protein_coding
description:
  Large subunit GTPase 1; Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm; Belongs to the TRAFAC class YlqF/YawG GTPase family. LSG1 subfamily.


ensembl_gene_id: YGL100W
symbol: SEH1
gene_biotype: protein_coding
description:
  Nucleoporin SEH1; Subunit of the Nup84 nuclear pore and SEACAT subcomplexes; involved in nucleocytoplasmic transport and NPC biogenesis in the nuclear pore subcomplex; subunit of SEACAT, a subcomplex of the SEA complex that inhibits the TORC1 inhibitory role of SEACIT (Iml1p-Npr2p-Npr3p), a GAP for Gtr1p in response to amino acid limitation, thereby resulting in activation of TORC1 signaling; SEA is a coatomer-related complex that associates dynamically with the vacuole; human SEH1 homolog.


ensembl_gene_id: YGL101W
symbol: YGL101W
gene_biotype: protein_coding
description:
  HD domain-containing protein YGL101W; Protein of unknown function; non-essential gene; interacts with the DNA helicase Hpr5p; YGL101W has a paralog, YBR242W, that arose from the whole genome duplication.


ensembl_gene_id: YGL102C
symbol: YGL102C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YGL102C; Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential RPL28 gene encoding a large subunit ribosomal protein.


ensembl_gene_id: YGL103W
symbol: RPL28
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L28; homologous to mammalian ribosomal protein L27A and bacterial L15; may have peptidyl transferase activity; can mutate to cycloheximide resistance.


ensembl_gene_id: YGL104C
symbol: VPS73
gene_biotype: protein_coding
description:
  Mitochondrial protein; mutation affects vacuolar protein sorting; putative transporter; member of the sugar porter family; VPS73 has a paralog, YBR241C, that arose from the whole genome duplication; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.


ensembl_gene_id: YGL105W
symbol: ARC1
gene_biotype: protein_coding
description:
  tRNA-aminoacylation cofactor ARC1; Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases; involved in tRNA delivery, stimulating catalysis, and ensuring localization; also binds quadruplex nucleic acids; protein abundance increases in response to DNA replication stress; methionyl-tRNA synthetase is Mes1p; glutamyl-tRNA synthetase is Gus1p.


ensembl_gene_id: YGL106W
symbol: MLC1
gene_biotype: protein_coding
description:
  Essential light chain for Myo1p; light chain for Myo2p; stabilizes Myo2p by binding to the neck region; interacts with Myo1p, Iqg1p, and Myo2p to coordinate formation and contraction of the actomyosin ring with targeted membrane deposition.


ensembl_gene_id: YGL107C
symbol: RMD9
gene_biotype: protein_coding
description:
  Mitochondrial protein required for respiratory growth; mutant phenotype and genetic interactions suggest a role in delivering mt mRNAs to ribosomes; located on matrix face of the inner membrane and loosely associated with mitoribosomes; RMD9 has a paralog, YBR238C, that arose from the whole genome duplication.


ensembl_gene_id: YGL108C
symbol: YGL108C
gene_biotype: protein_coding
description:
  Uncharacterized protein YGL108C; Protein of unknown function, predicted to be palmitoylated; SWAT-GFP, seamless-GFP and mCherry C-terminal fusion proteins localize to the cytosol, while N-terminal GFP fusion protein localizes to the cell periphery; protein abundance increases in response to DNA replication stress; To S.pombe new13.


ensembl_gene_id: YGL109W
symbol: YGL109W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YGL109W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the uncharacterized gene YGL108C.


ensembl_gene_id: YGL110C
symbol: CUE3
gene_biotype: protein_coding
description:
  Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination.


ensembl_gene_id: YGL111W
symbol: NSA1
gene_biotype: protein_coding
description:
  Ribosome biogenesis protein NSA1; Constituent of 66S pre-ribosomal particles; involved in 60S ribosomal subunit biogenesis.


ensembl_gene_id: YGL112C
symbol: TAF6
gene_biotype: protein_coding
description:
  Subunit (60 kDa) of TFIID and SAGA complexes; involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4; relocalizes to the cytosol in response to hypoxia.


ensembl_gene_id: YGL113W
symbol: SLD3
gene_biotype: protein_coding
description:
  Protein involved in the initiation of DNA replication; required for proper assembly of replication proteins at the origins of replication; interacts with Cdc45p; localizes to nuclear foci that become diffuse upon DNA replication stress; homologous to the human Treslin/Ticrr protein.


ensembl_gene_id: YGL114W
symbol: YGL114W
gene_biotype: protein_coding
description:
  Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters.


ensembl_gene_id: YGL115W
symbol: SNF4
gene_biotype: protein_coding
description:
  Activating gamma subunit of the AMP-activated Snf1p kinase complex; additional subunits of the complex are Snf1p and a Sip1p/Sip2p/Gal83p family member; activates glucose-repressed genes, represses glucose-induced genes; role in sporulation, and peroxisome biogenesis; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YGL116W
symbol: CDC20
gene_biotype: protein_coding
description:
  Activator of anaphase-promoting complex/cyclosome (APC/C); APC/C is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; cell-cycle regulated; potential Cdc28p substrate; relative distribution to the nucleus increases upon DNA replication stress; Belongs to the WD repeat CDC20/Fizzy family.


ensembl_gene_id: YGL118C
symbol: YGL118C
gene_biotype: protein_coding
description:
  Uncharacterized protein YGL118C; Putative protein of unknown function; conserved among S. cerevisiae strains; YGL118C is not an essential gene.


ensembl_gene_id: YGL119W
symbol: COQ8
gene_biotype: protein_coding
description:
  Atypical kinase COQ8, mitochondrial; ATPase required for ubiquinone biosynthesis and respiratory growth; maintains levels of CoQ biosynthetic proteins; binds to CoQ biosynthesis intermediates; UbiB protein kinase-like family member that lacks canonical protein kinase activity; similar to prokaryotic proteins involved in ubiquinone biosynthesis; human homolog ADCK3 complements a coq8 null, is associated with CoQ and respiratory-chain deficiencies, and is mutated in autosomal-recessive cerebellar ataxia type 2.


ensembl_gene_id: YGL120C
symbol: PRP43
gene_biotype: protein_coding
description:
  Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43; RNA helicase in the DEAH-box family; functions in both RNA polymerase I and polymerase II transcript metabolism; catalyzes removal of U2, U5, and U6 snRNPs from the postsplicing lariat-intron ribonucleoprotein complex; required for efficient biogenesis of both small- and large-subunit rRNAs; acts with Sqs1p to promote 20S to 18S rRNA processing catalyzed by endonuclease Nob1p; Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily.


ensembl_gene_id: YGL121C
symbol: GPG1
gene_biotype: protein_coding
description:
  Proposed gamma subunit of the heterotrimeric G protein; interacts with the receptor Gpr1p; involved in regulation of pseudohyphal growth; requires Gpb1p or Gpb2p to interact with Gpa2p; overproduction causes prion curing.


ensembl_gene_id: YGL122C
symbol: NAB2
gene_biotype: protein_coding
description:
  Nuclear polyadenylated RNA-binding protein; required for nuclear mRNA export and poly(A) tail length control; stimulates RNA polymerase III transcription by enhancing TFIIIB binding to promoters; protects mRNA against decay by the nuclear exosome in a poly(A)-tail-dependent manner; involved in forming export-competent mRNPs in the nucleus; autoregulates mRNA levels; NLS binds Kap104p; protein abundance increases under DNA replication stress; related to human hnRNPs; Belongs to the NAB2 family.


ensembl_gene_id: YGL123C-A
symbol: YGL123C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YGL123C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene RPS2/YGL123W.


ensembl_gene_id: YGL123W
symbol: RPS2
gene_biotype: protein_coding
description:
  Protein component of the small (40S) subunit; essential for control of translational accuracy; phosphorylation by C-terminal domain kinase I (CTDK-I) enhances translational accuracy; methylated on one or more arginine residues by Hmt1p; homologous to mammalian ribosomal protein S2 and bacterial S5.


ensembl_gene_id: YGL124C
symbol: MON1
gene_biotype: protein_coding
description:
  Vacuolar fusion protein MON1; Subunit of a heterodimeric guanine nucleotide exchange factor (GEF); subunit of the Mon1-Ccz1 GEF complex which stimulates nucleotide exchange and activation of Ypt7p, a Rab family GTPase involved in membrane tethering and fusion events at the late endosome and vacuole; GEF activity is stimulated by membrane association and anionic phospholipids; role in localizing Ypt7p to the vacuolar membrane; required for autophagy, the CVT pathway and mitophagy; potential Cdc28 substrate; Belongs to the MON1/SAND family.


ensembl_gene_id: YGL125W
symbol: MET13
gene_biotype: protein_coding
description:
  Major isozyme of methylenetetrahydrofolate reductase; catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway.


ensembl_gene_id: YGL126W
symbol: SCS3
gene_biotype: protein_coding
description:
  FIT family protein SCS3; Protein required for inositol prototrophy; required for normal ER membrane biosynthesis; ortholog of the FIT family of proteins involved in triglyceride droplet biosynthesis and homologous to human FIT2; disputed role in the synthesis of inositol phospholipids from inositol.


ensembl_gene_id: YGL127C
symbol: SOH1
gene_biotype: protein_coding
description:
  Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; involved in telomere maintenance; conserved with other metazoan MED31 subunits.


ensembl_gene_id: YGL128C
symbol: CWC23
gene_biotype: protein_coding
description:
  Pre-mRNA-splicing factor CWC23; Component of a complex containing Cef1p; putatively involved in pre-mRNA splicing; has similarity to E. coli DnaJ and other DnaJ-like proteins and to S. pombe Cwf23p.


ensembl_gene_id: YGL129C
symbol: RSM23
gene_biotype: protein_coding
description:
  Mitochondrial ribosomal protein of the small subunit; has similarity to mammalian apoptosis mediator proteins; null mutation prevents induction of apoptosis by overproduction of metacaspase Mca1p.


ensembl_gene_id: YGL130W
symbol: CEG1
gene_biotype: protein_coding
description:
  mRNA-capping enzyme subunit alpha; Guanylyltransferase involved in mRNA 5' capping; subunit of mRNA capping enzyme, which is a heterotetramer composed of two molecules of Ceg1p and a homodimer of Cet1p, the mRNA 5'-triphosphatase subunit; nuclear import of Ceg1p requires interaction with Cet1p; mammalian capping enzyme is a single bifunctional polypeptide; human homolog RNGTT can complement yeast ceg1 null mutant.


ensembl_gene_id: YGL131C
symbol: SNT2
gene_biotype: protein_coding
description:
  Subunit of Snt2C complex, RING finger ubiquitin ligase (E3); physically associates with Ecm5p and Rpd3p; along with Ecm5p, recruits Rpd3p to small number of promoters; colocalizes with Ecm5p, independently of Rpd3p, to promoters of stress response genes upon oxidative stress; involved in ubiquitination, degradation of excess histones; interacts with Ubc4p; role in regulating genes encoding amine transporters; relocalizes from nucleus to cytoplasm upon DNA replication stress.


ensembl_gene_id: YGL132W
symbol: YGL132W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YGL132W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene SNT2/YGL131C.


ensembl_gene_id: YGL133W
symbol: ITC1
gene_biotype: protein_coding
description:
  Imitation switch two complex protein 1; Subunit of ATP-dependent Isw2p-Itc1p chromatin remodeling complex; required for repression of a-specific genes, repression of early meiotic genes during mitotic growth, and repression of INO1; similar to mammalian Acf1p, the regulatory subunit of the mammalian ATP-utilizing chromatin assembly and modifying factor (ACF) complex; ITC1 has a paralog, YPL216W, that arose from the whole genome duplication.


ensembl_gene_id: YGL134W
symbol: PCL10
gene_biotype: protein_coding
description:
  Pho85p cyclin; recruits, activates, and targets Pho85p cyclin-dependent protein kinase to its substrate; PCL10 has a paralog, PCL8, that arose from the whole genome duplication.


ensembl_gene_id: YGL135W
symbol: RPL1B
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L1B; N-terminally acetylated; homologous to mammalian ribosomal protein L10A and bacterial L1; RPL1B has a paralog, RPL1A, that arose from the whole genome duplication; rpl1a rpl1b double null mutation is lethal.


ensembl_gene_id: YGL136C
symbol: MRM2
gene_biotype: protein_coding
description:
  Mitochondrial 2' O-ribose methyltransferase; required for methylation of U(2791) in 21S rRNA; MRM2 deletion confers thermosensitive respiration and loss of mitochondrial DNA; has similarity to Spb1p and Trm7p, and to E. coli FtsJ/RrmJ; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.


ensembl_gene_id: YGL137W
symbol: SEC27
gene_biotype: protein_coding
description:
  Coatomer subunit beta; Essential beta'-coat protein of the COPI coatomer; involved in ER-to-Golgi and Golgi-to-ER transport; contains WD40 domains that mediate cargo selective interactions; 45% sequence identity to mammalian beta'-COP.


ensembl_gene_id: YGL138C
symbol: YGL138C
gene_biotype: protein_coding
description:
  Uncharacterized protein YGL138C; Putative protein of unknown function; has no significant sequence similarity to any known protein.


ensembl_gene_id: YGL139W
symbol: FLC3
gene_biotype: protein_coding
description:
  Putative flavin carrier protein 3; Putative FAD transporter, similar to Flc1p and Flc2p; localized to the ER; FLC3 has a paralog, FLC1, that arose from the whole genome duplication; Belongs to the transient receptor potential (TRP) ion channel family.


ensembl_gene_id: YGL140C
symbol: YGL140C
gene_biotype: protein_coding
description:
  Uncharacterized membrane protein YGL140C; Putative protein of unknown function; non-essential gene; contains multiple predicted transmembrane domains.


ensembl_gene_id: YGL141W
symbol: HUL5
gene_biotype: protein_coding
description:
  Probable E3 ubiquitin-protein ligase HUL5; Multiubiquitin chain assembly factor (E4); proteasome processivity factor that elongates polyUb chains on substrates, opposing Ubp6p, a branched polyubiquitin protease; required for retrograde transport of misfolded proteins during ERAD; required for ubiquitination of a subset of cytosolic misfolded proteins upon heat shock.


ensembl_gene_id: YGL142C
symbol: GPI10
gene_biotype: protein_coding
description:
  GPI mannosyltransferase 3; Integral membrane protein involved in GPI anchor synthesis; putative alpha 1,2 mannosyltransferase required for addition of the third mannose onto the glycosylphosphatidylinositol (GPI) core structure; human PIG-Bp is a functional homolog.


ensembl_gene_id: YGL143C
symbol: MRF1
gene_biotype: protein_coding
description:
  Mitochondrial translation release factor; involved in stop codon recognition and hydrolysis of the peptidyl-tRNA bond during mitochondrial translation; lack of MRF1 causes mitochondrial genome instability.


ensembl_gene_id: YGL144C
symbol: ROG1
gene_biotype: protein_coding
description:
  Putative lipase ROG1; Lipase with specificity for monoacylglycerol; preferred substrate is 1-oleoylglycerol; null mutation affects lipid droplet morphology and overexpression causes increased accumulation of reactive oxygen species.


ensembl_gene_id: YGL145W
symbol: TIP20
gene_biotype: protein_coding
description:
  Peripheral membrane protein required for COPI vesicle fusion to the ER; mediates Sey1p-independent homotypic ER fusion; prohibits back-fusion of COPII vesicles with the ER; forms a tethering complex with Sec39p and Dsl1p that interacts with ER SNAREs Sec20p and Use1p.


ensembl_gene_id: YGL146C
symbol: RRT6
gene_biotype: protein_coding
description:
  Regulator of rDNA transcription protein 6; Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins.


ensembl_gene_id: YGL147C
symbol: RPL9A
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L9A; homologous to mammalian ribosomal protein L9 and bacterial L6; RPL9A has a paralog, RPL9B, that arose from a single-locus duplication.


ensembl_gene_id: YGL148W
symbol: ARO2
gene_biotype: protein_coding
description:
  Bifunctional chorismate synthase and flavin reductase; catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YGL149W
symbol: YGL149W
gene_biotype: protein_coding
description:
  Uncharacterized protein YGL149W; Putative protein of unknown function; conserved among S. cerevisiae strains; YGL149W is not an essential gene.


ensembl_gene_id: YGL150C
symbol: INO80
gene_biotype: protein_coding
description:
  Chromatin-remodeling ATPase INO80; ATPase and nucleosome spacing factor; subunit of complex containing actin and actin-related proteins that has chromatin remodeling activity and 3' to 5' DNA helicase activity in vitro; promotes nucleosome shifts in the 3 prime direction; has a role in modulating stress gene transcription.


ensembl_gene_id: YGL151W
symbol: NUT1
gene_biotype: protein_coding
description:
  Component of the RNA polymerase II mediator complex; mediator is required for transcriptional activation and also has a role in basal transcription.


ensembl_gene_id: YGL152C
symbol: YGL152C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YGL152C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF PEX14/YGL153W.


ensembl_gene_id: YGL153W
symbol: PEX14
gene_biotype: protein_coding
description:
  Peroxisomal membrane protein PEX14; Central component of the peroxisomal importomer complex; peroxisomal protein import machinery docking complex component; interacts with both PTS1 (Pex5p) and PTS2 (Pex7p) peroxisomal matrix protein signal recognition factors and membrane receptor Pex13p.


ensembl_gene_id: YGL154C
symbol: LYS5
gene_biotype: protein_coding
description:
  L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase; Phosphopantetheinyl transferase involved in lysine biosynthesis; converts inactive apo-form of Lys2p (alpha-aminoadipate reductase) into catalytically active holo-form by posttranslational addition of phosphopantetheine; Belongs to the P-Pant transferase superfamily. AcpS family.


ensembl_gene_id: YGL155W
symbol: CDC43
gene_biotype: protein_coding
description:
  Beta subunit of geranylgeranyltransferase type I; subunit of the Ram2p-Cdc43p heterodimer that catalyzes the geranylgeranylation of the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis.


ensembl_gene_id: YGL156W
symbol: AMS1
gene_biotype: protein_coding
description:
  Alpha-mannosidase; Vacuolar alpha mannosidase; involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway.


ensembl_gene_id: YGL157W
symbol: ARI1
gene_biotype: protein_coding
description:
  NADPH-dependent aldehyde reductase; utilizes aromatic and alophatic aldehyde substrates; member of the short-chain dehydrogenase/reductase superfamily.


ensembl_gene_id: YGL158W
symbol: RCK1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase RCK1; Protein kinase involved in oxidative stress response; promotes pseudohyphal growth via activation of Ubp3p phosphorylation; identified as suppressor of S. pombe cell cycle checkpoint mutations; RCK1 has a paralog, RCK2, that arose from the whole genome duplication.


ensembl_gene_id: YGL159W
symbol: YGL159W
gene_biotype: protein_coding
description:
  Uncharacterized protein YGL159W; Putative protein of unknown function; deletion mutant has no detectable phenotype.


ensembl_gene_id: YGL160W
symbol: AIM14
gene_biotype: protein_coding
description:
  Probable metalloreductase AIM14; NADPH oxidase localized to the perinuclear ER; produces superoxide from NADPH; overexpression causes MCA1 dependent apoptosis; likely involved in superoxide-mediated regulation of the actin cytoskeleton; member of a conserved superfamily of NADPH oxidases (NOX enzymes); has similarity to iron/copper reductases (FRE1-8), particularly Fre8p; Belongs to the ferric reductase (FRE) family. AIM14 subfamily.


ensembl_gene_id: YGL161C
symbol: YIP5
gene_biotype: protein_coding
description:
  Protein that interacts with Rab GTPases; localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport.


ensembl_gene_id: YGL162W
symbol: SUT1
gene_biotype: protein_coding
description:
  Sterol uptake protein 1; Zn(II)2Cys6 family transcription factor; positively regulates sterol uptake genes under anaerobic conditions; involved in hypoxic gene expression; represses filamentation-inducing genes during vegetative growth; positively regulates mating with SUT2 by repressing expression of genes that act as mating inhibitors; repressed by STE12; relocalizes from the nucleus to the cytoplasm upon DNA replication stress; SUT1 has a paralog, SUT2, that arose from the whole genome duplication.


ensembl_gene_id: YGL163C
symbol: RAD54
gene_biotype: protein_coding
description:
  DNA repair and recombination protein RAD54; DNA-dependent ATPase that stimulates strand exchange; modifies the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family of DNA translocases; forms nuclear foci upon DNA replication stress.


ensembl_gene_id: YGL164C
symbol: YRB30
gene_biotype: protein_coding
description:
  Ran-specific GTPase-activating protein 30; RanGTP-binding protein; inhibits RanGAP1 (Rna1p)-mediated GTP hydrolysis of RanGTP (Gsp1p); shares similarity to proteins in other fungi but not in higher eukaryotes.


ensembl_gene_id: YGL165C
symbol: YGL165C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YGL165C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CUP2/YGL166W.


ensembl_gene_id: YGL166W
symbol: CUP2
gene_biotype: protein_coding
description:
  Transcriptional activator protein CUP2; Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations; required for regulation of copper genes in response to DNA-damaging reagents; CUP2 has a paralog, HAA1, that arose from the whole genome duplication.


ensembl_gene_id: YGL167C
symbol: PMR1
gene_biotype: protein_coding
description:
  Calcium-transporting ATPase 1; High affinity Ca2+/Mn2+ P-type ATPase; required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting, processing; D53A mutant (Mn2+ transporting) is rapamycin sensitive, Q783A mutant (Ca2+ transporting) is rapamycin resistant; Mn2+ transport into Golgi lumen required for rapamycin sensitivity; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease; human ATP2C1 can complement yeast null mutant; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.


ensembl_gene_id: YGL168W
symbol: HUR1
gene_biotype: protein_coding
description:
  Putative uncharacterized protein HUR1; Protein of unknown function; reported null mutant phenotype of hydroxyurea sensitivity may be due to effects on overlapping PMR1 gene.


ensembl_gene_id: YGL169W
symbol: SUA5
gene_biotype: protein_coding
description:
  Threonylcarbamoyl-AMP synthase; Protein involved in threonylcarbamoyl adenosine biosynthesis; Sua5p and Qri7p are necessary and sufficient for RNA t6A modification in vitro; null mutant lacks N6-threonylcarbamoyl adenosine (t6A) modification in the anticodon loop of ANN-decoding tRNA; member of conserved YrdC/Sua5 family; binds single-stranded telomeric DNA and null mutant has abnormal telomere length.


ensembl_gene_id: YGL170C
symbol: SPO74
gene_biotype: protein_coding
description:
  Sporulation-specific protein 74; Component of the meiotic outer plaque of the spindle pole body; involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation.


ensembl_gene_id: YGL171W
symbol: ROK1
gene_biotype: protein_coding
description:
  ATP-dependent RNA helicase ROK1; RNA-dependent ATPase; involved in pre-rRNA processing at sites A0, A1, and A2, and in control of cell cycle progression; contains two upstream open reading frames (uORFs) in 5' untranslated region which regulate translation; Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.


ensembl_gene_id: YGL172W
symbol: NUP49
gene_biotype: protein_coding
description:
  FG-nucleoporin component of central core of the nuclear pore complex; contributes directly to nucleocytoplasmic transport and maintenance of the nuclear pore complex (NPC) permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup57p).


ensembl_gene_id: YGL173C
symbol: XRN1
gene_biotype: protein_coding
description:
  5'-3' exoribonuclease 1; Evolutionarily-conserved 5'-3' exonuclease; component of cytoplasmic processing (P) bodies involved in mRNA decay; also enters the nucleus and positively regulates transcription initiation and elongation; plays a role in microtubule-mediated processes, filamentous growth, ribosomal RNA maturation, and telomere maintenance; activated by the scavenger decapping enzyme Dcs1p.


ensembl_gene_id: YGL174W
symbol: BUD13
gene_biotype: protein_coding
description:
  Pre-mRNA-splicing factor CWC26; Subunit of the RES complex; RES complex is required for nuclear pre-mRNA retention and splicing; involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern due to a specific defect in MATa1 pre-mRNA splicing which leads to haploid gene expression in diploids; Belongs to the CWC26 family.


ensembl_gene_id: YGL175C
symbol: SAE2
gene_biotype: protein_coding
description:
  DNA endonuclease SAE2; Endonuclease required for telomere elongation; required for telomeric 5' C-rich strand resection; involved in ds-break repair and processing hairpin DNA structures with the MRX complex; function requires sumoylation and phosphorylation; exists as inactive oligomers that are transiently released into smaller active units by phosphorylation; DNA damage triggers Sae2p removal, so active Sae2p is present only transiently; sequence and functional similarity with human CtIP/RBBP8; Belongs to the COM1/SAE2/CtIP family.


ensembl_gene_id: YGL176C
symbol: YGL176C
gene_biotype: protein_coding
description:
  Uncharacterized protein YGL176C; Putative protein of unknown function; deletion mutant is viable and has no detectable phenotype.


ensembl_gene_id: YGL177W
symbol: YGL177W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YGL177W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YGL178W
symbol: MPT5
gene_biotype: protein_coding
description:
  Suppressor protein MPT5; mRNA-binding protein of the PUF family; binds to specific mRNAs, often in the 3' UTR; has broad specificity and binds to more than 1000 mRNAs (16% of the transcriptome); recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity.


ensembl_gene_id: YGL179C
symbol: TOS3
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase TOS3; Protein kinase; related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p; functionally orthologous to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome; TOS3 has a paralog, SAK1, that arose from the whole genome duplication.


ensembl_gene_id: YGL180W
symbol: ATG1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase ATG1; Protein serine/threonine kinase; required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; structurally required for phagophore assembly site formation; during autophagy forms a complex with Atg13p and Atg17p; essential for cell cycle progression from G2/M to G1 under nitrogen starvation.


ensembl_gene_id: YGL181W
symbol: GTS1
gene_biotype: protein_coding
description:
  Protein involved in Arf3p regulation and in transcription regulation; localizes to the nucleus and to endocytic patches; contains an N-terminal Zn-finger and ArfGAP homology domain, a C-terminal glutamine-rich region, and a UBA (ubiquitin associated) domain; gts1 mutations affect budding, cell size, heat tolerance, sporulation, life span, ultradian rhythms, endocytosis; expression oscillates in a pattern similar to metabolic oscillations.


ensembl_gene_id: YGL182C
symbol: YGL182C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YGL182C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MND1/YGL183C.


ensembl_gene_id: YGL183C
symbol: MND1
gene_biotype: protein_coding
description:
  Protein required for recombination and meiotic nuclear division; forms a complex with Hop2p, which is involved in chromosome pairing and repair of meiotic double-strand breaks.


ensembl_gene_id: YGL184C
symbol: STR3
gene_biotype: protein_coding
description:
  Peroxisomal cystathionine beta-lyase; converts cystathionine into homocysteine; may be redox regulated by Gto1p; involved in the release of the aromatic thiol 3-mercaptohexanol during wine fermentation.


ensembl_gene_id: YGL185C
symbol: YGL185C
gene_biotype: protein_coding
description:
  Putative protein with sequence similar to hydroxyacid dehydrogenases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm.


ensembl_gene_id: YGL186C
symbol: TPN1
gene_biotype: protein_coding
description:
  Plasma membrane pyridoxine (vitamin B6) transporter; member of the purine-cytosine permease subfamily within the major facilitator superfamily; proton symporter with similarity to Fcy21p, Fcy2p, and Fcy22p.


ensembl_gene_id: YGL187C
symbol: COX4
gene_biotype: protein_coding
description:
  Subunit IV of cytochrome c oxidase; the terminal member of the mitochondrial inner membrane electron transport chain; precursor N-terminal 25 residues are cleaved during mitochondrial import; phosphorylated; spermidine enhances translation.


ensembl_gene_id: YGL188C
symbol: YGL188C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YGL188C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YGL189C
symbol: RPS26A
gene_biotype: protein_coding
description:
  Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S26, no bacterial homolog; RPS26A has a paralog, RPS26B, that arose from the whole genome duplication; human homolog can partially complement an RPS26A, RPS26B double null mutant; mutations in the human gene are associated with Diamond-Blackfan anemia.


ensembl_gene_id: YGL190C
symbol: CDC55
gene_biotype: protein_coding
description:
  Regulatory subunit B of protein phosphatase 2A (PP2A); Zds1p/2p-dependent localization to cytoplasm promotes mitotic entry; localization to nucleus prevents mitotic exit; required for correct nuclear division, chromosome segregation during achiasmate meiosis; maintains nucleolar sequestration of Cdc14p during early meiosis; limits formation of PP2A-Rts1p holocomplexes to ensure timely dissolution of sister chromosome cohesion; homolog of mammalian B55.


ensembl_gene_id: YGL191W
symbol: COX13
gene_biotype: protein_coding
description:
  Subunit VIa of cytochrome c oxidase; present in a subclass of cytochrome c oxidase complexes that may have a role in mimimizing generation of reactive oxygen species; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP; required for assembly of Rcf2p into cytochrome c oxidase - cytochrome bc1 supercomplexes.


ensembl_gene_id: YGL192W
symbol: IME4
gene_biotype: protein_coding
description:
  N6-adenosine-methyltransferase IME4; mRNA N6-adenosine methyltransferase required for entry into meiosis; mediates N6-adenosine methylation of bulk mRNA during the induction of sporulation which includes the meiotic regulators IME1, IME2 and IME4 itself; repressed in haploids via production of antisense IME4 transcripts; transcribed in diploid cells where antisense transcription is repressed; orthologous to human METTL3 (MT-A70); Belongs to the MT-A70-like family.


ensembl_gene_id: YGL193C
symbol: YGL193C
gene_biotype: protein_coding
description:
  Uncharacterized protein YGL193C; Haploid-specific gene repressed by a1-alpha2; turned off in sir3 null strains, absence enhances the sensitivity of rad52-327 cells to campothecin almost 100-fold.


ensembl_gene_id: YGL194C
symbol: HOS2
gene_biotype: protein_coding
description:
  Histone deacetylase and subunit of Set3 and Rpd3L complexes; required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; co-localizes with Cmr1p in nuclear foci in response to DNA damage by MMS.


ensembl_gene_id: YGL194C-A
symbol: YGL194C-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YGL194C-A; Putative protein of unknown function; identified based on comparisons of the genome sequences of six Saccharomyces species; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum.


ensembl_gene_id: YGL195W
symbol: GCN1
gene_biotype: protein_coding
description:
  eIF-2-alpha kinase activator GCN1; Positive regulator of the Gcn2p kinase activity; forms a complex with Gcn20p; proposed to stimulate Gcn2p activation by an uncharged tRNA; Belongs to the GCN1 family.


