# geneInfo

ensembl_gene_id: YML051W
symbol: GAL80
gene_biotype: protein_coding
description:
  Galactose/lactose metabolism regulatory protein GAL80; Transcriptional regulator involved in the repression of GAL genes; involved in the repression of GAL genes in the absence of galactose; inhibits transcriptional activation by Gal4p; inhibition relieved by Gal3p or Gal1p binding; To K.lactis GAL80.


ensembl_gene_id: YML052W
symbol: SUR7
gene_biotype: protein_coding
description:
  Plasma membrane protein, component of eisosomes; long-lived protein that remains stable in eisosomes of mother cells while other eisosome proteins, Pil1p and Lsp1p, turn over; may function to anchor the eisosome in place; sporulation and plasma membrane sphingolipid content are altered in mutants; localizes to furrow-like invaginations (MCC patches).


ensembl_gene_id: YML053C
symbol: YML053C
gene_biotype: protein_coding
description:
  Uncharacterized protein YML053C; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; overexpression causes a cell cycle delay or arrest; YML053C is not an essential gene.


ensembl_gene_id: YML054C
symbol: CYB2
gene_biotype: protein_coding
description:
  Cytochrome b2, mitochondrial; Cytochrome b2 (L-lactate cytochrome-c oxidoreductase); component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions.


ensembl_gene_id: YML055W
symbol: SPC2
gene_biotype: protein_coding
description:
  Subunit of signal peptidase complex; complex catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC25; other members of the complex are Spc1p, Spc1p, and Sec11p.


ensembl_gene_id: YML056C
symbol: IMD4
gene_biotype: protein_coding
description:
  Inosine-5'-monophosphate dehydrogenase 4; Inosine monophosphate dehydrogenase; catalyzes the rate-limiting step in the de novo synthesis of GTP; member of a four-gene family in S. cerevisiae, constitutively expressed; IMD4 has a paralog, IMD3, that arose from the whole genome duplication.


ensembl_gene_id: YML057C-A
symbol: YML057C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized membrane protein YML057C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene CMP2/YML057W.


ensembl_gene_id: YML057W
symbol: CMP2
gene_biotype: protein_coding
description:
  Serine/threonine-protein phosphatase 2B catalytic subunit A2; Calcineurin A; one isoform (the other is Cna1p) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1; regulates the function of Aly1p alpha-arrestin; CMP2 has a paralog, CNA1, that arose from the whole genome duplication; Belongs to the PPP phosphatase family. PP-2B subfamily.


ensembl_gene_id: YML058W
symbol: SML1
gene_biotype: protein_coding
description:
  Ribonucleotide reductase inhibitor; involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase; SML1 has a paralog, DIF1, that arose from the whole genome duplication.


ensembl_gene_id: YML058W-A
symbol: HUG1
gene_biotype: protein_coding
description:
  MEC1-mediated checkpoint protein HUG1; Ribonucleotide reductase inhibitor; intrinsically disordered protein that binds to and inhibits Rnr2p; involved in the Mec1p-mediated checkpoint pathway; transcription is induced by genotoxic stress and by activation of the Rad53p pathway; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YML059C
symbol: NTE1
gene_biotype: protein_coding
description:
  Lysophospholipase NTE1; Serine esterase; homolog of human neuropathy target esterase (NTE); Nte1p-mediated phosphatidylcholine turnover influences transcription factor Opi1p localization, affecting transcriptional regulation of phospholipid biosynthesis genes.


ensembl_gene_id: YML060W
symbol: OGG1
gene_biotype: protein_coding
description:
  DNA-(apurinic or apyrimidinic site) lyase; Nuclear and mitochondrial glycosylase/lyase; specifically excises 7,8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA, repairs oxidative damage to mitochondrial DNA, contributes to UVA resistance; Belongs to the type-1 OGG1 family.


ensembl_gene_id: YML061C
symbol: PIF1
gene_biotype: protein_coding
description:
  DNA helicase, potent G-quadruplex DNA binder/unwinder; possesses strand annealing activity; promotes DNA synthesis during break-induced replication; important for crossover recombination; translation from different start sites produces mitochondrial and nuclear forms; nuclear form is a catalytic inhibitor of telomerase; mitochondrial form involved in DNA repair and recombination; mutations affect Zn, Fe homeostasis; regulated by Rad53p-dependent phosphorylation in rho0 cells.


ensembl_gene_id: YML062C
symbol: MFT1
gene_biotype: protein_coding
description:
  Subunit of the THO complex; THO is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance.


ensembl_gene_id: YML063W
symbol: RPS1B
gene_biotype: protein_coding
description:
  Ribosomal protein 10 (rp10) of the small (40S) subunit; homologous to mammalian ribosomal protein S3A, no bacterial homolog; RPS1B has a paralog, RPS1A, that arose from the whole genome duplication.


ensembl_gene_id: YML064C
symbol: TEM1
gene_biotype: protein_coding
description:
  GTP-binding protein of the Ras superfamily; involved in termination of M-phase; controls actomyosin and septin dynamics during cytokinesis.


ensembl_gene_id: YML065W
symbol: ORC1
gene_biotype: protein_coding
description:
  Largest subunit of the origin recognition complex; involved in directing DNA replication by binding to replication origins; also involved in transcriptional silencing; exhibits ATPase activity; ORC1 has a paralog, SIR3, that arose from the whole genome duplication.


ensembl_gene_id: YML066C
symbol: SMA2
gene_biotype: protein_coding
description:
  Meiosis-specific prospore membrane protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation; Belongs to the SMA2 family.


ensembl_gene_id: YML067C
symbol: ERV41
gene_biotype: protein_coding
description:
  Protein localized to COPII-coated vesicles; forms a complex with Erv46p; involved in the membrane fusion stage of transport; has homology to human ERGIC2 (PTX1) protein.


ensembl_gene_id: YML068W
symbol: ITT1
gene_biotype: protein_coding
description:
  Protein that modulates the efficiency of translation termination; interacts with translation release factors eRF1 (Sup45p) and eRF3 (Sup35p) in vitro, contains a zinc finger domain characteristic of the TRIAD class of proteins; Belongs to the RBR family.


ensembl_gene_id: YML069W
symbol: POB3
gene_biotype: protein_coding
description:
  Subunit of the heterodimeric FACT complex (Spt16p-Pob3p); FACT associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases; protein abundance increases in response to DNA replication stress; Belongs to the SSRP1 family.


ensembl_gene_id: YML070W
symbol: DAK1
gene_biotype: protein_coding
description:
  Dihydroxyacetone kinase; required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation.


ensembl_gene_id: YML072C
symbol: TCB3
gene_biotype: protein_coding
description:
  Tricalbin-3; Cortical ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to the plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; localized to the bud via specific mRNA transport; non-tagged protein detected in a phosphorylated state in mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact; Belongs to the tricalbin family.


ensembl_gene_id: YML073C
symbol: RPL6A
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L6A; N-terminally acetylated; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6A has a paralog, RPL6B, that arose from the whole genome duplication.


ensembl_gene_id: YML074C
symbol: FPR3
gene_biotype: protein_coding
description:
  FK506-binding nuclear protein; Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; affects expression of multiple genes via its role in nucleosome assembly; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p; PPIase domain acts as a transcriptional repressor when tethered to DNA by lexA, and repressor activity is dependent on PPIase activity; FPR3 has a paralog, FPR4, that arose from the whole genome duplication; Belongs to the FKBP-type PPIase family. FKBP3/4 subfamily.


ensembl_gene_id: YML075C
symbol: HMG1
gene_biotype: protein_coding
description:
  HMG-CoA reductase; catalyzes conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; one of two isozymes; localizes to nuclear envelope; overproduction induces formation of karmellae; forms foci at nuclear periphery upon DNA replication stress; HMG1 has a paralog, HMG2, that arose from the whole genome duplication; human homolog HMGCR can complement yeast hmg1 mutant.


ensembl_gene_id: YML076C
symbol: WAR1
gene_biotype: protein_coding
description:
  Weak acid resistance protein 1; Homodimeric Zn2Cys6 zinc finger transcription factor; binds to a weak acid response element to induce transcription of PDR12 and FUN34, encoding an acid transporter and a putative ammonia transporter, respectively.


ensembl_gene_id: YML077W
symbol: BET5
gene_biotype: protein_coding
description:
  Core component of transport protein particle (TRAPP) complexes I-III; TRAPP complexes are related multimeric guanine nucleotide-exchange factors for the GTPase Ypt1p, regulating ER-Golgi traffic (TRAPPI), intra-Golgi traffic (TRAPPII), endosome-Golgi traffic (TRAPPII and III) and autophagy (TRAPPIII); human homology TRAPPC1 complements yeast null mutant; Belongs to the TRAPP small subunits family. BET5 subfamily.


ensembl_gene_id: YML078W
symbol: CPR3
gene_biotype: protein_coding
description:
  Mitochondrial peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; involved in protein refolding after import into mitochondria.


ensembl_gene_id: YML079W
symbol: YML079W
gene_biotype: protein_coding
description:
  Uncharacterized protein YML079W; Non-essential protein of unknown function; has structural resemblance to plant storage and ligand binding proteins (canavalin, glycinin, auxin binding protein) and to some enzymes (epimerase, germin); localizes to the nucleus and cytoplasm.


ensembl_gene_id: YML080W
symbol: DUS1
gene_biotype: protein_coding
description:
  tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]; Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus3p, and Dus4p; modifies pre-tRNA(Phe) at U17; Belongs to the Dus family. Dus1 subfamily.


ensembl_gene_id: YML081C-A
symbol: ATP18
gene_biotype: protein_coding
description:
  Subunit of the mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms.


ensembl_gene_id: YML081W
symbol: TDA9
gene_biotype: protein_coding
description:
  Transcription factor that regulates acetate production; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene; TDA9 has a paralog, RSF2, that arose from the whole genome duplication; Belongs to the RSF2/TDA9 family.


ensembl_gene_id: YML082W
symbol: YML082W
gene_biotype: protein_coding
description:
  Putative cystathionine gamma-synthase YML082W; Putative protein predicted to have carbon-sulfur lyase activity; transcriptionally regulated by Upc2p via an upstream sterol response element; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and the cytoplasm; not an essential gene; YML082W has a paralog, STR2, that arose from the whole genome duplication.


ensembl_gene_id: YML083C
symbol: YML083C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YML083C; Protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions.


ensembl_gene_id: YML084W
symbol: YML084W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YML084W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YML085C
symbol: TUB1
gene_biotype: protein_coding
description:
  Tubulin alpha-1 chain; Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; relative distribution to nuclear foci increases upon DNA replication stress; TUB1 has a paralog, TUB3, that arose from the whole genome duplication.


ensembl_gene_id: YML086C
symbol: ALO1
gene_biotype: protein_coding
description:
  D-Arabinono-1,4-lactone oxidase; catalyzes the final step in biosynthesis of dehydro-D-arabinono-1,4-lactone, which is protective against oxidative stress.


ensembl_gene_id: YML087C
symbol: AIM33
gene_biotype: protein_coding
description:
  Uncharacterized oxidoreductase AIM33; Protein of unknown function, highly conserved across species; homolog of human CYB5R4; null mutant displays reduced frequency of mitochondrial genome loss; AIM33 has a paralog, PGA3, that arose from the whole genome duplication.


ensembl_gene_id: YML088W
symbol: UFO1
gene_biotype: protein_coding
description:
  F-box receptor protein; subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex; binds to phosphorylated Ho endonuclease, allowing its ubiquitination by SCF and subsequent degradation.


ensembl_gene_id: YML089C
symbol: YML089C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YML089C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by calcium shortage.


ensembl_gene_id: YML090W
symbol: YML090W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YML090W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YML089C; exhibits growth defect on a non-fermentable (respiratory) carbon source.


ensembl_gene_id: YML091C
symbol: RPM2
gene_biotype: protein_coding
description:
  Protein subunit of mitochondrial RNase P; has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation; distributed to mitochondria, cytoplasmic processing bodies, and the nucleus.


ensembl_gene_id: YML093W
symbol: UTP14
gene_biotype: protein_coding
description:
  U3 small nucleolar RNA-associated protein 14; Subunit of U3-containing Small Subunit (SSU) processome complex; involved in production of 18S rRNA and assembly of small ribosomal subunit; Belongs to the UTP14 family.


ensembl_gene_id: YML094C-A
symbol: YML094C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YML094C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene GIM5/YML094W; deletion confers sensitivity to GSAO.


ensembl_gene_id: YML094W
symbol: GIM5
gene_biotype: protein_coding
description:
  Prefoldin subunit 5; Subunit of the heterohexameric cochaperone prefoldin complex; prefoldin binds specifically to cytosolic chaperonin and transfers target proteins to it; prefoldin complex also localizes to chromatin of actively transcribed genes in the nucleus and facilitates transcriptional elongation.


ensembl_gene_id: YML095C
symbol: RAD10
gene_biotype: protein_coding
description:
  DNA repair protein RAD10; Single-stranded DNA endonuclease (with Rad1p); cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human ERCC1 protein; Belongs to the ERCC1/RAD10/SWI10 family.


ensembl_gene_id: YML096W
symbol: YML096W
gene_biotype: protein_coding
description:
  Putative protein with similarity to asparagine synthetases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YML096W is not an essential gene and partially overlaps the verified gene RAD10.


ensembl_gene_id: YML097C
symbol: VPS9
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 9; Guanine nucleotide exchange factor (GEF) and ubiquitin receptor; involved in vesicle-mediated vacuolar transport, including Golgi-endosome trafficking and sorting through the multivesicular body (MVB); stimulates the intrinsic guanine nucleotide exchange activity of Rab family members (Vps21p/Ypt52p/Ypt53p); partially redundant with GEF MUK1; required for localization of the CORVET complex to endosomes; similar to mammalian ras inhibitors; contains a Ub-interacting CUE domain.


ensembl_gene_id: YML098W
symbol: TAF13
gene_biotype: protein_coding
description:
  TFIID subunit (19 kDa); involved in RNA polymerase II transcription initiation, similar to histone H4 with atypical histone fold motif of Spt3-like transcription factors.


ensembl_gene_id: YML099C
symbol: ARG81
gene_biotype: protein_coding
description:
  Arginine metabolism regulation protein II; Zinc finger transcription factor involved in arginine-responsive genes; Zn(2)-Cys(6) binuclear cluster domain type; involved in the regulation of arginine-responsive genes; acts with Arg80p and Arg82p.


ensembl_gene_id: YML099W-A
symbol: YML099W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YML099W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF ARG81/YML099C.


ensembl_gene_id: YML100W
symbol: TSL1
gene_biotype: protein_coding
description:
  Large subunit of trehalose 6-phosphate synthase/phosphatase complex; Tps1p-Tps2p complex converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose; contributes to survival to acute lethal heat stress; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress; TSL1 has a paralog, TPS3, that arose from the whole genome duplication.


ensembl_gene_id: YML100W-A
symbol: YML100W-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YML100W-A; Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching.


ensembl_gene_id: YML101C
symbol: CUE4
gene_biotype: protein_coding
description:
  Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; CUE4 has a paralog, CUE1, that arose from the whole genome duplication.


ensembl_gene_id: YML101C-A
symbol: YML101C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YML101C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YML102W
symbol: CAC2
gene_biotype: protein_coding
description:
  Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p; chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure, deactivation of the DNA damage checkpoint after DNA repair, chromatin dynamics during transcription; and repression of divergent transcription; relocalizes to the cytosol in response to hypoxia.


ensembl_gene_id: YML103C
symbol: NUP188
gene_biotype: protein_coding
description:
  Nucleoporin NUP188; Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188.


ensembl_gene_id: YML104C
symbol: MDM1
gene_biotype: protein_coding
description:
  Structural protein MDM1; PtdIns-3-P binding protein that tethers the ER to vacuoles at NVJs; anchored in the ER membrane at nucleus-vacuole junctions and binds phosphatidylinositol 3-phosphate (PtdIns-3-P) in the vacuolar membrane via its Phox homology (PX) domain; expressed predominantly in late G1 to early S phase of the cell cycle; mutation affects nuclear and mitochondrial transmission to daughter buds; similar to 4 human genes, one of which (SNX14) is associated with neurological disease.


ensembl_gene_id: YML105C
symbol: SEC65
gene_biotype: protein_coding
description:
  Subunit of the signal recognition particle (SRP); involved in protein targeting to the ER; interacts with Srp54p; homolog of mammalian SRP19.


ensembl_gene_id: YML106W
symbol: URA5
gene_biotype: protein_coding
description:
  Major orotate phosphoribosyltransferase (OPRTase) isozyme; catalyzes the fifth enzymatic step in de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; URA5 has a paralog, URA10, that arose from the whole genome duplication; Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.


ensembl_gene_id: YML107C
symbol: PML39
gene_biotype: protein_coding
description:
  Pre-mRNA leakage protein 39; Protein required for nuclear retention of unspliced pre-mRNAs; required along with Mlp1p and Pml1p; anchored to nuclear pore complex via Mlp1p and Mlp2p; found with the subset of nuclear pores farthest from the nucleolus; may interact with ribosomes.


ensembl_gene_id: YML108W
symbol: YML108W
gene_biotype: protein_coding
description:
  Uncharacterized protein YML108W; Protein of unknown function; structure defines a new subfamily of the split beta-alpha-beta sandwiches; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YML108W is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress.


ensembl_gene_id: YML109W
symbol: ZDS2
gene_biotype: protein_coding
description:
  Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintenance of Cdc55p in the cytoplasm where it promotes mitotic entry; interacts with silencing proteins at the telomere; implicated in the mitotic exit network through regulation of Cdc14p localization; ZDS2 has a paralog, ZDS1, that arose from the whole genome duplication.


ensembl_gene_id: YML110C
symbol: COQ5
gene_biotype: protein_coding
description:
  2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; respiratory defect of the null mutant is partially complemented by human COQ5; Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.


ensembl_gene_id: YML111W
symbol: BUL2
gene_biotype: protein_coding
description:
  Ubiquitin ligase-binding protein BUL2; Component of the Rsp5p E3-ubiquitin ligase complex; involved in intracellular amino acid permease sorting, functions in heat shock element mediated gene expression, essential for growth in stress conditions; BUL2 has a paralog, BUL1, that arose from the whole genome duplication; Belongs to the BUL1 family.


ensembl_gene_id: YML112W
symbol: CTK3
gene_biotype: protein_coding
description:
  Gamma subunit of C-terminal domain kinase I; CTDK-I phosphorylates RNA polymerase II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and also phosphorylates ribosomal protein Rps2p to increase translational fidelity; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YML113W
symbol: DAT1
gene_biotype: protein_coding
description:
  DNA binding protein that recognizes oligo(dA).oligo(dT) tracts; Arg side chain in its N-terminal pentad Gly-Arg-Lys-Pro-Gly repeat is required for DNA-binding; relocalizes to the cytosol in response to hypoxia; not essential for viability.


ensembl_gene_id: YML115C
symbol: VAN1
gene_biotype: protein_coding
description:
  Component of the mannan polymerase I; complex contains Van1p and Mnn9p and is involved in the first steps of mannan synthesis; mutants are vanadate-resistant.


ensembl_gene_id: YML116W
symbol: ATR1
gene_biotype: protein_coding
description:
  Aminotriazole resistance protein; Multidrug efflux pump of the major facilitator superfamily; required for resistance to aminotriazole and 4-nitroquinoline-N-oxide; ATR1 has a paralog, YMR279C, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YML117W
symbol: NAB6
gene_biotype: protein_coding
description:
  Putative RNA-binding protein; associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP.


ensembl_gene_id: YML118W
symbol: NGL3
gene_biotype: protein_coding
description:
  3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication.


ensembl_gene_id: YML120C
symbol: NDI1
gene_biotype: protein_coding
description:
  Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial; NADH:ubiquinone oxidoreductase; transfers electrons from NADH to ubiquinone in respiratory chain but does not pump protons, in contrast to higher eukaryotic multisubunit respiratory complex I; upon apoptotic stress, is activated in mitochondria by N-terminal cleavage, then translocates to cytoplasm to induce apoptosis; homolog of human AIFM2; yeast NDI1 complements several phenotypes of human cell line with mutated MT-ND4, implicated in Leber hereditary optic neuropathy.


ensembl_gene_id: YML121W
symbol: GTR1
gene_biotype: protein_coding
description:
  GTP-binding protein GTR1; Subunit of a TORC1-stimulating GTPase complex; subunit of the heterodimeric Gtr1-Gtr2 GTPase complex that stimulates TORC1 in response to amino acid stimulation; tethered to the vacuolar membrane as part of the EGOC, a complex required for sorting of Gap1p and microautophagy; involved in phosphate transport and telomeric chromatin silencing; activated by the the Iml1p (GAP) subunit of the SEACIT complex; similar to human RagA and RagB.


ensembl_gene_id: YML122C
symbol: YML122C
gene_biotype: protein_coding
description:
  Uncharacterized protein YML122C; Putative protein of unknown function; conserved among S. cerevisiae strains; YML122C is not an essential gene.


ensembl_gene_id: YML123C
symbol: PHO84
gene_biotype: protein_coding
description:
  High-affinity inorganic phosphate (Pi) transporter; also low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturation requires Pho86p; cells overexpressing Pho84p accumulate heavy metals but do not develop symptoms of metal toxicity.


ensembl_gene_id: YML124C
symbol: TUB3
gene_biotype: protein_coding
description:
  Tubulin alpha-3 chain; Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p; TUB3 has a paralog, TUB1, that arose from the whole genome duplication.


ensembl_gene_id: YML125C
symbol: PGA3
gene_biotype: protein_coding
description:
  Plasma membrane-associated coenzyme Q6 reductase PGA3; Putative cytochrome b5 reductase, localized to the plasma membrane; may be involved in regulation of lifespan; required for maturation of Gas1p and Pho8p, proposed to be involved in protein trafficking; PGA3 has a paralog, AIM33, that arose from the whole genome duplication.


ensembl_gene_id: YML126C
symbol: ERG13
gene_biotype: protein_coding
description:
  3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase; catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis.


ensembl_gene_id: YML127W
symbol: RSC9
gene_biotype: protein_coding
description:
  Chromatin structure-remodeling complex subunit RSC9; Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway; Belongs to the RSC9 family.


ensembl_gene_id: YML128C
symbol: MSC1
gene_biotype: protein_coding
description:
  Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria and is phosphorylated.


ensembl_gene_id: YML129C
symbol: COX14
gene_biotype: protein_coding
description:
  Mitochondrial cytochrome c oxidase (complex IV) assembly factor; also involved in translational regulation of Cox1p and prevention of Cox1p aggregation before assembly; associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; located in the mitochondrial membrane.


ensembl_gene_id: YML130C
symbol: ERO1
gene_biotype: protein_coding
description:
  Endoplasmic oxidoreductin-1; Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining ER redox balance; feedback regulated via reduction and oxidation of regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds; ero1-1 mutation complemented by human ERO1L.


ensembl_gene_id: YML131W
symbol: YML131W
gene_biotype: protein_coding
description:
  Uncharacterized membrane protein YML131W; Protein of unknown function; similar to medium chain dehydrogenase/reductases; expression induced by stresses including osmotic shock, DNA damaging agents, and other chemicals; GFP-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YML133C
symbol: YML133C
gene_biotype: protein_coding
description:
  Putative Y' element ATP-dependent helicase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YML133C contains an intron.


ensembl_gene_id: YML133W-A
symbol: YML133W-A
gene_biotype: protein_coding
description:
  Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the uncharacterized ORF YML133C.


ensembl_gene_id: YMR001C
symbol: CDC5
gene_biotype: protein_coding
description:
  Cell cycle serine/threonine-protein kinase CDC5/MSD2; Polo-like kinase; controls targeting and activation of Rho1p at cell division site via Rho1p guanine nucleotide exchange factors; regulates Spc72p; also functions in adaptation to DNA damage during meiosis; regulates the shape of the nucleus and expansion of the nuclear envelope during mitosis; similar to Xenopus Plx1 and S. pombe Plo1p; human homologs PLK1, PLK3 can each complement yeast cdc5 thermosensitive mutants; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.


ensembl_gene_id: YMR002W
symbol: MIX17
gene_biotype: protein_coding
description:
  Mitochondrial intermembrane space protein; required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YMR003W
symbol: AIM34
gene_biotype: protein_coding
description:
  Altered inheritance of mitochondria protein 34, mitochondrial; Protein of unknown function; GFP-fusion protein localizes to the mitochondria; null mutant is viable and displays reduced frequency of mitochondrial genome loss.


ensembl_gene_id: YMR004W
symbol: MVP1
gene_biotype: protein_coding
description:
  Sorting nexin MVP1; Protein required for sorting proteins to the vacuole; Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole; participates in transcription initiation and/or early elongation of specific genes; interacts with foot domain of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YMR005W
symbol: TAF4
gene_biotype: protein_coding
description:
  TFIID subunit (48 kDa); involved in RNA polymerase II transcription initiation; potential Cdc28p substrate.


ensembl_gene_id: YMR006C
symbol: PLB2
gene_biotype: protein_coding
description:
  Phospholipase B (lysophospholipase) involved in lipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine.


ensembl_gene_id: YMR007W
symbol: YMR007W
gene_biotype: protein_coding
description:
  Uncharacterized protein YMR007W; Putative protein of unknown function; conserved among S. cerevisiae strains; YMR007W is not an essential gene.


ensembl_gene_id: YMR008C
symbol: PLB1
gene_biotype: protein_coding
description:
  Phospholipase B (lysophospholipase) involved in lipid metabolism; required for efficient acyl chain remodeling of newly synthesized phosphatidylethanolamine-derived phosphatidylcholine; required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol; PLB1 has a paralog, PLB3, that arose from the whole genome duplication.


ensembl_gene_id: YMR009W
symbol: ADI1
gene_biotype: protein_coding
description:
  1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Acireductone dioxygenease involved in methionine salvage pathway; transcribed as polycistronic mRNA with YMR010W and regulated post-transcriptionally by RNase III (Rnt1p) cleavage; ADI1 mRNA is induced in heat shock conditions; human ortholog ADI1 can complement yeast adi1 mutant; Belongs to the acireductone dioxygenase (ARD) family.


ensembl_gene_id: YMR010W
symbol: ANY1
gene_biotype: protein_coding
description:
  Scramblase ANY1; Putative protein of unknown function; null allele suppresses the lethality of neo1 and dop1 null alleles, as well as the growth defect of a mon2 null allele, and the cold sensitivity of a drs2 null; proposed function as a phospholipid scramblase that reduces membrane asymmetry; PQ loop family member; localizes to the cytoplasm and endoplasmic reticulum in HTP studies; non-essential gene.


ensembl_gene_id: YMR011W
symbol: HXT2
gene_biotype: protein_coding
description:
  High-affinity glucose transporter of the major facilitator superfamily; expression is induced by low levels of glucose and repressed by high levels of glucose; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.


ensembl_gene_id: YMR012W
symbol: CLU1
gene_biotype: protein_coding
description:
  Clustered mitochondria protein 1; Subunit of the eukaryotic translation initiation factor 3 (eIF3); component of unknown function; deletion causes defects in mitochondrial organization but not in growth or translation initiation; can rescue cytokinesis and mitochondrial organization defects of the Dictyostelium cluA- mutant; eIF3 is also involved in programmed stop codon readthrough.


ensembl_gene_id: YMR013C
symbol: SEC59
gene_biotype: protein_coding
description:
  Dolichol kinase; catalyzes the terminal step in dolichyl monophosphate (Dol-P) biosynthesis; required for viability and for normal rates of lipid intermediate synthesis and protein N-glycosylation; Belongs to the polyprenol kinase family.


ensembl_gene_id: YMR013C-A
symbol: YMR013C-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YMR013C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF SEC59/YML013C.


ensembl_gene_id: YMR013W-A
symbol: YMR013W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YMR013W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the characterized snoRNA gene snR73.


ensembl_gene_id: YMR014W
symbol: BUD22
gene_biotype: protein_coding
description:
  Bud site selection protein 22; Protein required for rRNA maturation and ribosomal subunit biogenesis; required for 18S rRNA maturation; also required for small ribosomal subunit biogenesis; cosediments with pre-ribosomal particles; mutation decreases efficiency of +1 Ty1 frameshifting and transposition, and affects budding pattern.


ensembl_gene_id: YMR015C
symbol: ERG5
gene_biotype: protein_coding
description:
  Cytochrome P450 61; C-22 sterol desaturase; a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs.


ensembl_gene_id: YMR016C
symbol: SOK2
gene_biotype: protein_coding
description:
  Nuclear protein that negatively regulates pseudohyphal differentiation; plays a regulatory role in the cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway; relocalizes to the cytosol in response to hypoxia; SOK2 has a paralog, PHD1, that arose from the whole genome duplication.


ensembl_gene_id: YMR017W
symbol: SPO20
gene_biotype: protein_coding
description:
  Sporulation-specific protein 20; Meiosis-specific subunit of the t-SNARE complex; required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; binds to phosphatidic acid; SNAP-25 homolog.


ensembl_gene_id: YMR018W
symbol: PEX9
gene_biotype: protein_coding
description:
  Peroxisomal targeting signal receptor 9; Putative protein of unknown function with similarity to human PEX5Rp; transcription increases during colony development similar to genes involved in peroxisome biogenesis; YMR018W is not an essential gene; PEX5Rp is also known as peroxin protein 5 related protein.


ensembl_gene_id: YMR019W
symbol: STB4
gene_biotype: protein_coding
description:
  Probable transcriptional regulatory protein STB4; Putative transcription factor; contains a Zn(II)2Cys6 zinc finger domain characteristic of DNA-binding proteins; computational analysis suggests a role in regulation of expression of genes encoding transporters; binds Sin3p in a two-hybrid assay.


ensembl_gene_id: YMR020W
symbol: FMS1
gene_biotype: protein_coding
description:
  Polyamine oxidase; converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis; Belongs to the flavin monoamine oxidase family.


ensembl_gene_id: YMR021C
symbol: MAC1
gene_biotype: protein_coding
description:
  Metal-binding activator 1; Copper-sensing transcription factor; involved in regulation of genes required for high affinity copper transport; required for regulation of yeast copper genes in response to DNA-damaging agents; undergoes changes in redox state in response to changing levels of copper or MMS.


ensembl_gene_id: YMR022W
symbol: UBC7
gene_biotype: protein_coding
description:
  Ubiquitin-conjugating enzyme E2 7; Ubiquitin conjugating enzyme; involved in the ER-associated protein degradation (ERAD) pathway and in the inner nuclear membrane-associated degradation (INMAD) pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly.


ensembl_gene_id: YMR023C
symbol: MSS1
gene_biotype: protein_coding
description:
  tRNA modification GTPase MSS1, mitochondrial; Mitochondrial protein; forms a heterodimer complex with Mto1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; similar to human GTPBP3; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.


ensembl_gene_id: YMR024W
symbol: MRPL3
gene_biotype: protein_coding
description:
  Mitochondrial ribosomal protein of the large subunit; located in close proximity to the polypeptide exit channel of the ribosome; mutations in human homolog MRPL44 cause childhood cardiomyopathy; human MRPL44 deficiency results in inefficient assembly of the mitochondrial ribosome, and in tissue-specific respiratory chain deficiency, manifesting as either Complex I+Complex IV or Complex IV deficiency, depending on a cell type; Belongs to the ribonuclease III family. Mitochondrion- specific ribosomal protein mL44 subfamily.


ensembl_gene_id: YMR025W
symbol: CSI1
gene_biotype: protein_coding
description:
  Cop9 signalosome-interactor 1; Subunit of the Cop9 signalosome; which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling; functional equivalent of canonical Csn6 subunit of the COP9 signalosome.


ensembl_gene_id: YMR026C
symbol: PEX12
gene_biotype: protein_coding
description:
  Peroxisome assembly protein 12; C3HC4-type RING-finger peroxin and E3 ubiquitin ligase; required for peroxisome biogenesis and peroxisomal matrix protein import; forms translocation subcomplex with Pex2p and Pex10p; mutations in human homolog cause peroxisomal disorder; Belongs to the pex2/pex10/pex12 family.


ensembl_gene_id: YMR027W
symbol: YMR027W
gene_biotype: protein_coding
description:
  Damage-control phosphatase YMR027W; A metal-dependent phosphatase, part of the DUF89 protein family; dephosphorylates fructose-1-phosphate; human ortholog, C6orf211 is involved in response to DNA damage; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR027W is not an essential gene; Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.


ensembl_gene_id: YMR028W
symbol: TAP42
gene_biotype: protein_coding
description:
  Type 2A phosphatase-associated protein 42; Essential protein involved in the TOR signaling pathway; physically associates with the protein phosphatase 2A and the SIT4 protein phosphatase catalytic subunits; Belongs to the IGBP1/TAP42 family.


ensembl_gene_id: YMR029C
symbol: FAR8
gene_biotype: protein_coding
description:
  Protein involved in recovery from arrest in response to pheromone; acts in a cell cycle arrest recovery pathway independent from Far1p; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p.


ensembl_gene_id: YMR030W
symbol: RSF1
gene_biotype: protein_coding
description:
  Respiration factor 1; Protein required for respiratory growth; localized to both the nucleus and mitochondrion; may interact with transcription factors to mediate the transition to respiratory growth and activate transcription of nuclear and mitochondrial genes.


ensembl_gene_id: YMR030W-A
symbol: YMR030W-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YMR030W-A; Putative protein of unknown function; mCherry fusion protein localizes to the cytosol.


ensembl_gene_id: YMR031C
symbol: EIS1
gene_biotype: protein_coding
description:
  Eisosome protein 1; Component of the eisosome required for proper eisosome assembly; similar to Uso1p; authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress; EIS1 has a paralog, YKL050C, that arose from the whole genome duplication.


ensembl_gene_id: YMR031W-A
symbol: YMR031W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YMR031W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C.


ensembl_gene_id: YMR032W
symbol: HOF1
gene_biotype: protein_coding
description:
  Cytokinesis protein 2; Protein that regulates actin cytoskeleton organization; required for cytokinesis, actin cable organization, and secretory vesicle trafficking; localized to bud neck; phosphorylated by Dbf2p; regulates actomyosin ring dynamics and septin localization; contains an SH3 domain; N terminus controls cell size and levels of actin cables, while C terminus controls actin cable organization via direct regulation of the formin Bnr1p.


ensembl_gene_id: YMR033W
symbol: ARP9
gene_biotype: protein_coding
description:
  Actin-like protein ARP9; Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation.


ensembl_gene_id: YMR034C
symbol: RCH1
gene_biotype: protein_coding
description:
  Solute carrier RCH1; Putative transporter; localizes to the plasma membrane in response to high levels of extracellular calcium; member of the SLC10 carrier family; identified in a transposon mutagenesis screen as a gene involved in azole resistance; YMR034C is not an essential gene.


ensembl_gene_id: YMR035W
symbol: IMP2-2
gene_biotype: protein_coding
description:
  Catalytic subunit of mitochondrial inner membrane peptidase complex; required for maturation of mitochondrial proteins of the intermembrane space; complex contains two catalytic subunits (Imp1p and Imp2p that differ in substrate specificity), and Som1p.


ensembl_gene_id: YMR036C
symbol: MIH1
gene_biotype: protein_coding
description:
  M-phase inducer phosphatase; Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25; Belongs to the MPI phosphatase family.


ensembl_gene_id: YMR037C
symbol: MSN2
gene_biotype: protein_coding
description:
  Zinc finger protein MSN2; Stress-responsive transcriptional activator; activated in stochastic pulses of nuclear localization in response to various stress conditions; binds DNA at stress response elements of responsive genes; relative distribution to nucleus increases upon DNA replication stress.


ensembl_gene_id: YMR038C
symbol: CCS1
gene_biotype: protein_coding
description:
  Copper chaperone for superoxide dismutase Sod1p; involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within N-terminus is involved in insertion of copper into Sod1p under conditions of copper deprivation; required for regulation of yeast copper genes in response to DNA-damaging agents; protein abundance increases in response to DNA replication stress; human homolog CCS can complement yeast ccs1 null mutant; Belongs to the CCS1 family.


ensembl_gene_id: YMR039C
symbol: SUB1
gene_biotype: protein_coding
description:
  Transcriptional regulator; facilitates elongation through factors that modify RNAP II; role in peroxide resistance involving Rad2p; role in nonhomologous end-joining (NHEJ) of ds breaks in plasmid DNA, but not chromosomal DNA; role in the hyperosmotic stress response through polymerase recruitment at RNAP II and RNAP III genes; negatively regulates sporulation; protein abundance increases in response to DNA replication stress; functionally complemented by human SUB1 (PC4).


ensembl_gene_id: YMR040W
symbol: YET2
gene_biotype: protein_coding
description:
  Endoplasmic reticulum transmembrane protein 2; Protein of unknown function that may interact with ribosomes; based on co-purification experiments; homolog of human BAP31 protein; YET2 has a paralog, YET1, that arose from the whole genome duplication.


ensembl_gene_id: YMR041C
symbol: ARA2
gene_biotype: protein_coding
description:
  D-arabinose 1-dehydrogenase; NAD-dependent arabinose dehydrogenase; involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase; Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.


ensembl_gene_id: YMR042W
symbol: ARG80
gene_biotype: protein_coding
description:
  Arginine metabolism regulation protein I; Transcription factor involved in regulating arginine-responsive genes; acts with Arg81p and Arg82p.


ensembl_gene_id: YMR043W
symbol: MCM1
gene_biotype: protein_coding
description:
  Transcription factor; involved in cell-type-specific transcription and pheromone response; plays a central role in the formation of both repressor and activator complexes; relocalizes to the cytosol in response to hypoxia.


ensembl_gene_id: YMR044W
symbol: IOC4
gene_biotype: protein_coding
description:
  ISWI one complex protein 4; Member of a complex (Isw1b) with Isw1p and Ioc2p; interacts directly with H3K36me3 nucleosomes through its PWWP domain to recruit the Isw1b complex to open reading frames in a Set2p-dependent manner; Isw1b exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing.


ensembl_gene_id: YMR046W-A
symbol: YMR046W-A
gene_biotype: protein_coding
description:
  Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YMR047C
symbol: NUP116
gene_biotype: protein_coding
description:
  FG-nucleoporin component of central core of the nuclear pore complex; contributes directly to nucleocytoplasmic transport and maintenance of the nuclear pore complex (NPC) permeability barrier; forms a stable association with Nup82p, Gle2p and two other FG-nucleoporins (Nsp1p and Nup159p); NUP116 has a paralog, NUP100, that arose from the whole genome duplication.


ensembl_gene_id: YMR048W
symbol: CSM3
gene_biotype: protein_coding
description:
  Chromosome segregation in meiosis protein 3; Replication fork associated factor; required for stable replication fork pausing; component of the DNA replication checkpoint pathway; required for accurate chromosome segregation during meiosis; forms nuclear foci upon DNA replication stress.


ensembl_gene_id: YMR049C
symbol: ERB1
gene_biotype: protein_coding
description:
  Ribosome biogenesis protein ERB1; Constituent of 66S pre-ribosomal particles; forms a complex with Nop7p and Ytm1p that is required for maturation of the large ribosomal subunit; required for maturation of the 25S and 5.8S ribosomal RNAs; homologous to mammalian Bop1.


ensembl_gene_id: YMR052C-A
symbol: YMR052C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YMR052C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YMR052W
symbol: FAR3
gene_biotype: protein_coding
description:
  Factor arrest protein 3; Protein of unknown function; involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far7p, Far8p, Far9p, Far10p, and Far11p; localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YMR053C
symbol: STB2
gene_biotype: protein_coding
description:
  Protein that interacts with Sin3p in a two-hybrid assay; part of a large protein complex with Sin3p and Stb1p; STB2 has a paralog, STB6, that arose from the whole genome duplication.


ensembl_gene_id: YMR054W
symbol: STV1
gene_biotype: protein_coding
description:
  V-type proton ATPase subunit a, Golgi isoform; Subunit a of the vacuolar-ATPase V0 domain; one of two isoforms (Stv1p and Vph1p); Stv1p is located in V-ATPase complexes of the Golgi and endosomes while Vph1p is located in V-ATPase complexes of the vacuole; Belongs to the V-ATPase 116 kDa subunit family.


ensembl_gene_id: YMR055C
symbol: BUB2
gene_biotype: protein_coding
description:
  Mitotic check point protein BUB2; Mitotic exit network regulator; forms GTPase-activating Bfa1p-Bub2p complex that binds Tem1p and spindle pole bodies, blocks cell cycle progression before anaphase in response to spindle and kinetochore damage; Belongs to the BUB2 family.


ensembl_gene_id: YMR056C
symbol: AAC1
gene_biotype: protein_coding
description:
  ADP,ATP carrier protein 1; Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator; relocalizes from mitochondrion to cytoplasm upon DNA replication stress; Belongs to the mitochondrial carrier (TC 2.A.29) family.


ensembl_gene_id: YMR057C
symbol: YMR057C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YMR057C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified ORF AAC1.


ensembl_gene_id: YMR058W
symbol: FET3
gene_biotype: protein_coding
description:
  Iron transport multicopper oxidase FET3; Ferro-O2-oxidoreductase; multicopper oxidase that oxidizes ferrous (Fe2+) to ferric iron (Fe3+) for subsequent cellular uptake by transmembrane permease Ftr1p; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YMR059W
symbol: SEN15
gene_biotype: protein_coding
description:
  Subunit of the tRNA splicing endonuclease; tRNA splicing endonuclease (Sen complex) is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen complex also cleaves the CBP1 mRNA at the mitochondrial surface.


ensembl_gene_id: YMR060C
symbol: SAM37
gene_biotype: protein_coding
description:
  Component of the Sorting and Assembly Machinery (SAM) complex; the SAM (or TOB) complex is located in the mitochondrial outer membrane; binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; contributes to SAM complex stability.


ensembl_gene_id: YMR061W
symbol: RNA14
gene_biotype: protein_coding
description:
  mRNA 3'-end-processing protein RNA14; Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; bridges interaction between Rna15p and Hrp1p in the CF I complex; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; required for gene looping and maintenance of genome stability; relocalizes to the cytosol in response to hypoxia.


ensembl_gene_id: YMR062C
symbol: ARG7
gene_biotype: protein_coding
description:
  Mitochondrial ornithine acetyltransferase; catalyzes the fifth step in arginine biosynthesis; also possesses acetylglutamate synthase activity, regenerates acetylglutamate while forming ornithine; Belongs to the ArgJ family.


ensembl_gene_id: YMR063W
symbol: RIM9
gene_biotype: protein_coding
description:
  pH-response regulator protein palI/RIM9; Plasma membrane protein of unknown function; involved in the proteolytic activation of Rim101p in response to alkaline pH; interacts with Rim21p and Dfg16p to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; has similarity to A. nidulans PalI;; Belongs to the palI/RIM9 family.


ensembl_gene_id: YMR064W
symbol: AEP1
gene_biotype: protein_coding
description:
  Protein required for expression of the mitochondrial OLI1 gene; mitochondrial OLI1 gene encodes subunit 9 of F1-F0 ATP synthase.


ensembl_gene_id: YMR065W
symbol: KAR5
gene_biotype: protein_coding
description:
  Protein required for nuclear membrane fusion during karyogamy; localizes to the membrane with a soluble portion in the endoplasmic reticulum lumen, may form a complex with Jem1p and Kar2p; similar to zebrafish Brambleberry protein; expression of the gene is regulated by pheromone; Belongs to the KAR5 family.


ensembl_gene_id: YMR067C
symbol: UBX4
gene_biotype: protein_coding
description:
  UBX domain-containing protein that interacts with Cdc48p; involved in degradation of polyubiquitinated proteins via the ERAD (ER-associated degradation) pathway; modulates the Cdc48p-Nplp-Ufd1p AAA ATPase complex during its role in delivery of misfolded proteins to the proteasome; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YMR068W
symbol: AVO2
gene_biotype: protein_coding
description:
  Target of rapamycin complex 2 subunit AVO2; Component of a complex containing the Tor2p kinase and other proteins; complex may have a role in regulation of cell growth.


ensembl_gene_id: YMR069W
symbol: NAT4
gene_biotype: protein_coding
description:
  N-alpha-acetyltransferase 40; N alpha-acetyl-transferase; involved in acetylation of the N-terminal residues of histones H4 and H2A; Belongs to the acetyltransferase family. NAA40 subfamily.


ensembl_gene_id: YMR070W
symbol: MOT3
gene_biotype: protein_coding
description:
  Transcriptional activator/repressor MOT3; Transcriptional repressor, activator; role in cellular adjustment to osmotic stress including modulation of mating efficiency; involved in repression of subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, ergosterol biosynthetic genes in response to hyperosmotic stress; contributes to recruitment of Tup1p-Cyc8p general repressor to promoters; relocalizes to cytosol under hypoxia; forms [MOT3+] prion under anaerobic conditions.


ensembl_gene_id: YMR071C
symbol: TVP18
gene_biotype: protein_coding
description:
  Integral membrane protein; localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments; may have a role in intracellular sterol transport.


ensembl_gene_id: YMR072W
symbol: ABF2
gene_biotype: protein_coding
description:
  ARS-binding factor 2, mitochondrial; Mitochondrial DNA-binding protein; involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation; ABF2 has a paralog, IXR1, that arose from the whole genome duplication; human homolog TFAM can complement yeast abf2 mutant, rescuing the loss-of-mitochondrial DNA phenotype in a yeast abf2 strain.


ensembl_gene_id: YMR073C
symbol: IRC21
gene_biotype: protein_coding
description:
  Increased recombination centers protein 21; Protein of unknown function; may be involved in resistance to carboplatin and cisplatin; null mutant displays increase in spontaneous Rad52p foci; contains a lipid-binding domain and binds cardiolipin in a large-scale study.


ensembl_gene_id: YMR074C
symbol: SDD2
gene_biotype: protein_coding
description:
  Uncharacterized protein YMR074C; Protein with homology to human PDCD5; PDCD5 is involved in programmed cell death; N-terminal region forms a conserved triple-helix bundle structure; overproduction suppresses lethality due to expression of the dominant PET9 allele AAC2-A128P; overexpression promotes H2O2-induced apoptosis; YMR074C is not an essential gene; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YMR075C-A
symbol: YMR075C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YMR075C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RCO1/YMR075W.


ensembl_gene_id: YMR075W
symbol: RCO1
gene_biotype: protein_coding
description:
  Transcriptional regulatory protein RCO1; Essential component of the Rpd3S histone deacetylase complex; interacts with Eaf3p.


ensembl_gene_id: YMR076C
symbol: PDS5
gene_biotype: protein_coding
description:
  Cohesion maintenance factor; involved in sister chromatid condensation and cohesion; colocalizes with cohesin on chromosomes; performs its cohesin maintenance function in pre-anaphase cells by protecting the integrity of the cohesion complex; also required during meiosis; relocalizes to the cytosol in response to hypoxia.


ensembl_gene_id: YMR077C
symbol: VPS20
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 20; Myristoylated subunit of the ESCRT-III complex; the endosomal sorting complex required for transport of transmembrane proteins into the multivesicular body pathway to the lysosomal/vacuolar lumen; cytoplasmic protein recruited to endosomal membranes.


ensembl_gene_id: YMR078C
symbol: CTF18
gene_biotype: protein_coding
description:
  Chromosome transmission fidelity protein 18; Subunit of a complex with Ctf8p; shares some subunits with Replication Factor C and is required for sister chromatid cohesion; may have overlapping functions with Rad24p in the DNA damage replication checkpoint; Belongs to the activator 1 small subunits family. CTF18 subfamily.


ensembl_gene_id: YMR079W
symbol: SEC14
gene_biotype: protein_coding
description:
  SEC14 cytosolic factor; Phosphatidylinositol/phosphatidylcholine transfer protein; involved in regulating PtdIns, PtdCho, and ceramide metabolism, products of which regulate intracellular transport and UPR; has a role in localization of lipid raft proteins; functionally homologous to mammalian PITPs; SEC14 has a paralog, YKL091C, that arose from the whole genome duplication.


ensembl_gene_id: YMR080C
symbol: NAM7
gene_biotype: protein_coding
description:
  ATP-dependent RNA helicase of the SFI superfamily; involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; binds to the small ribosomal subunit via an interaction with Rps26; forms cytoplasmic foci upon DNA replication stress.


ensembl_gene_id: YMR081C
symbol: ISF1
gene_biotype: protein_coding
description:
  Increasing suppression factor 1; Serine-rich, hydrophilic protein; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant; ISF1 has a paralog, MBR1, that arose from the whole genome duplication; Belongs to the ISF1/MBR1 family.


ensembl_gene_id: YMR082C
symbol: YMR082C
gene_biotype: protein_coding
description:
  Uncharacterized protein YMR082C; Putative protein of unknown function; conserved among S. cerevisiae strains; YMR082C is not an essential gene.


ensembl_gene_id: YMR083W
symbol: ADH3
gene_biotype: protein_coding
description:
  Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production.


ensembl_gene_id: YMR084W
symbol: YMR084W
gene_biotype: protein_coding
description:
  Putative glutamine--fructose-6-phosphate aminotransferase [isomerizing]; Putative protein of unknown function; YMR084W and adjacent ORF YMR085W are merged in related strains, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1.


ensembl_gene_id: YMR085W
symbol: YMR085W
gene_biotype: protein_coding
description:
  Putative protein of unknown function; YMR085W and adjacent ORF YMR084W are merged in related strains, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1.


ensembl_gene_id: YMR086C-A
symbol: YMR086C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YMR086C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YMR086W
symbol: SEG1
gene_biotype: protein_coding
description:
  Eisosome protein SEG1; Component of eisosome required for proper eisosome assembly; precedes Pil1p/Lsp1p during eisosome formation, controls eisosome length and shape; diffusely distributed, forms heterogeneous patches at plasma membrane in small buds, also found in medium and large buds; expression repressed by cAMP; similar to A. gossypii SEG gene and to S. pombe Sle1p, important for generating eisosomes; SEG1 has a paralog, SEG2, that arose from the whole genome duplication.


ensembl_gene_id: YMR087W
symbol: YMR087W
gene_biotype: protein_coding
description:
  Probable ADP-ribose 1''-phosphate phosphatase YML087W; Putative ADP-ribose-1''-monophosphatase; converts ADP-ribose-1''-monophosphate to ADP-ribose; may have a role in tRNA splicing; contains an A1pp domain.


ensembl_gene_id: YMR089C
symbol: YTA12
gene_biotype: protein_coding
description:
  Mitochondrial respiratory chain complexes assembly protein YTA12; Mitochondrial inner membrane m-AAA protease component; mediates degradation of misfolded or unassembled proteins; also required for correct assembly of mitochondrial enzyme complexes; overexpression of human AFG3L2 complements respiratory defect of yeast afg3 yta12 double null mutation, but overexpression of disease-associated AFG3L2 variants does not; expression of both human SPG7 (paraplegin) and AFG3L2 complements yeast yta12 afg3 double mutation; In the N-terminal section; belongs to the AAA ATPase family.


ensembl_gene_id: YMR090W
symbol: YMR090W
gene_biotype: protein_coding
description:
  UPF0659 protein YMR090W; Putative protein of unknown function; similar to DTDP-glucose 4,6-dehydratases; GFP-fusion protein localizes to the cytoplasm; up-regulated in response to the fungicide mancozeb; not essential for viability; Belongs to the UPF0659 family.


ensembl_gene_id: YMR091C
symbol: NPL6
gene_biotype: protein_coding
description:
  Chromatin structure-remodeling complex subunit RSC7; Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Ldb7p, and Htl1p to form a module important for a broad range of RSC functions.


ensembl_gene_id: YMR092C
symbol: AIP1
gene_biotype: protein_coding
description:
  Actin-interacting protein 1; Actin cortical patch component; interacts with the actin depolymerizing factor cofilin; inhibits elongation of aged ADP-actin filaments decorated with cofilin to maintain a high level of assembly-competent actin species; required to restrict cofilin localization to cortical patches; putative regulator of cytokinesis; contains WD repeats; protein increases in abundance and relocalizes from cytoplasm to plasma membrane upon DNA replication stress.


ensembl_gene_id: YMR094W
symbol: CTF13
gene_biotype: protein_coding
description:
  Subunit of the CBF3 complex; CBF3 binds to the CDE III element of centromeres, bending the DNA upon binding, and may be involved in sister chromatid cohesion during mitosis.


ensembl_gene_id: YMR095C
symbol: SNO1
gene_biotype: protein_coding
description:
  Pyridoxal 5'-phosphate synthase subunit SNO1; Protein of unconfirmed function; involved in pyridoxine metabolism; expression is induced during stationary phase; forms a putative glutamine amidotransferase complex with Snz1p, with Sno1p serving as the glutaminase; Belongs to the glutaminase PdxT/SNO family.


ensembl_gene_id: YMR096W
symbol: SNZ1
gene_biotype: protein_coding
description:
  Pyridoxal 5'-phosphate synthase subunit SNZ1; Protein involved in vitamin B6 biosynthesis; member of a stationary phase-induced gene family; coregulated with SNO1; interacts with Sno1p and with Yhr198p, perhaps as a multiprotein complex containing other Snz and Sno proteins; Belongs to the PdxS/SNZ family.


ensembl_gene_id: YMR097C
symbol: MTG1
gene_biotype: protein_coding
description:
  Mitochondrial GTPase 1; Putative GTPase peripheral to the mitochondrial inner membrane; essential for respiratory competence, likely functions in assembly of the large ribosomal subunit, has homologs in plants and animals.


ensembl_gene_id: YMR098C
symbol: ATP25
gene_biotype: protein_coding
description:
  ATPase synthesis protein 25, mitochondrial; Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA; also required for the Oli1p ring formation; YMR098C is not an essential gene.


ensembl_gene_id: YMR099C
symbol: YMR099C
gene_biotype: protein_coding
description:
  Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase); likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS.


ensembl_gene_id: YMR100W
symbol: MUB1
gene_biotype: protein_coding
description:
  MYND-type zinc finger protein MUB1; MYND domain-containing protein; component of the Mub1p-Ubr2p-Rad6p ubiquitin ligase complex, required for ubiquitination and degradation of Rpn4p; interacts with Ubr2p (E3) and indirectly with Rad6p (E2); short-lived protein degraded in a Ubr2p/Rad6p dependent manner; proposed to function as both a partner and substrate of the Ubr2p/Rad6p ubiquitin ligase; similar to the A. nidulans samB gene.


ensembl_gene_id: YMR101C
symbol: SRT1
gene_biotype: protein_coding
description:
  Forms the dehydrodolichyl diphosphate syntase (DDS) complex with NUS1; involved in synthesis of long-chain dolichols (19-22 isoprene units; as opposed to Rer2p which synthesizes shorter-chain dolichols); localizes to lipid bodies; transcription is induced during stationary phase.


ensembl_gene_id: YMR102C
symbol: YMR102C
gene_biotype: protein_coding
description:
  WD repeat-containing protein YMR102C; Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; not an essential gene; YMR102C has a paralog, DGR2, that arose from the whole genome duplication.


ensembl_gene_id: YMR103C
symbol: YMR103C
gene_biotype: protein_coding
description:
  Uncharacterized protein YMR103C; Putative protein of unknown function; conserved among S. cerevisiae strains; YMR103C is not an essential gene.


ensembl_gene_id: YMR104C
symbol: YPK2
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase YPK2/YKR2; Protein kinase similar to S/T protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; involved in the TORC-dependent phosphorylation of ribosomal proteins Rps6a/b (S6); human homolog SGK2 can complement a ypk1 ypk2 double mutant.


ensembl_gene_id: YMR105C
symbol: PGM2
gene_biotype: protein_coding
description:
  Phosphoglucomutase; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase; protein abundance increases in response to DNA replication stress; PGM2 has a paralog, PGM1, that arose from the whole genome duplication.


ensembl_gene_id: YMR106C
symbol: YKU80
gene_biotype: protein_coding
description:
  ATP-dependent DNA helicase II subunit 2; Subunit of telomeric Ku complex (Yku70p-Yku80p); involved in telomere length maintenance, structure and telomere position effect; required for localization of telomerase ribonucleoprotein via interaction with TLC1 guide RNA; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair; colocalizes with quiescent cell telomere hyperclusters; Belongs to the ku80 family.


ensembl_gene_id: YMR107W
symbol: SPG4
gene_biotype: protein_coding
description:
  Stationary phase protein 4; Protein required for high temperature survival during stationary phase; not required for growth on nonfermentable carbon sources; Belongs to the SPG4 family.


ensembl_gene_id: YMR108W
symbol: ILV2
gene_biotype: protein_coding
description:
  Acetolactate synthase catalytic subunit, mitochondrial; Acetolactate synthase; catalyses the first common step in isoleucine and valine biosynthesis and is the target of several classes of inhibitors, localizes to the mitochondria; expression of the gene is under general amino acid control; Belongs to the TPP enzyme family.


ensembl_gene_id: YMR109W
symbol: MYO5
gene_biotype: protein_coding
description:
  Myosin-5; One of two type I myosin motors; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization; MYO5 has a paralog, MYO3, that arose from the whole genome duplication; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.


ensembl_gene_id: YMR110C
symbol: HFD1
gene_biotype: protein_coding
description:
  Fatty aldehyde dehydrogenase HFD1; Dehydrogenase involved in ubiquinone and sphingolipid metabolism; oxidizes 4-hydroxybenzaldehyde into 4-hydroxybenzoic acid in ubiquinone biosynthesis; converts hexadecenal to hexadecenoic acid in sphingosine 1-phosphate breakdown pathway; located in the mitochondrial outer membrane and also in lipid particles; human homolog ALDH3A2, a fatty aldehyde dehydrogenase (FALDH) mutated in neurocutaneous disorder Sjogren-Larsson syndrome, can complement yeast hfd1 mutant.


ensembl_gene_id: YMR111C
symbol: YMR111C
gene_biotype: protein_coding
description:
  Transcription factor-like protein EUC1; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR111C is not an essential gene; forms nuclear foci upon DNA replication stress.


ensembl_gene_id: YMR112C
symbol: MED11
gene_biotype: protein_coding
description:
  Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential protein.


ensembl_gene_id: YMR113W
symbol: FOL3
gene_biotype: protein_coding
description:
  Dihydrofolate synthetase, involved in folic acid biosynthesis; catalyzes conversion of dihydropteroate to dihydrofolate in folate coenzyme biosynthesis; FOL3 has a paralog, RMA1, that arose from the whole genome duplication.


ensembl_gene_id: YMR114C
symbol: YMR114C
gene_biotype: protein_coding
description:
  Abasic site processing protein YMR114C; Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR114C is not an essential gene; Belongs to the SOS response-associated peptidase family.


ensembl_gene_id: YMR115W
symbol: MGR3
gene_biotype: protein_coding
description:
  Subunit of the mitochondrial (mt) i-AAA protease supercomplex; i-AAA degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr1p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA.


ensembl_gene_id: YMR116C
symbol: ASC1
gene_biotype: protein_coding
description:
  G-protein beta subunit and guanine dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; required to prevent frameshifting at ribosomes stalled at repeated CGA codons; regulates P-body formation induced by replication stress; represses Gcn4p in the absence of amino acid starvation.


ensembl_gene_id: YMR117C
symbol: SPC24
gene_biotype: protein_coding
description:
  Kinetochore protein SPC24; Component of the kinetochore-associated Ndc80 complex; involved in chromosome segregation, spindle checkpoint activity, and kinetochore clustering; evolutionarily conserved; other members include Ndc80p, Nuf2p, Spc24p, and Spc25p.


ensembl_gene_id: YMR118C
symbol: SHH3
gene_biotype: protein_coding
description:
  Putative mitochondrial inner membrane protein of unknown function; although similar to paralogous Sdh3p, Shh3p is not a stoichiometric subunit of either succinate dehydrogenase or of the TIM22 translocase; SHH3 has a paralog, SDH3, that arose from the whole genome duplication.


ensembl_gene_id: YMR119W
symbol: ASI1
gene_biotype: protein_coding
description:
  Protein ASI1; Subunit of the inner nuclear membrane Asi ubiquitin ligase complex; the Asi complex targets both misfolded proteins of the inner nuclear membrane-associated degradation (INMAD) pathway and regulators of sterol biosynthesis for ubiquitin-mediated degradation; acts with Asi2p and Asi3p to ensure the fidelity of SPS-sensor signaling by targeting latent unprocessed forms of Stp1p and Stp2p, maintaining the repressed state of gene expression in the absence of inducing amino acids.


ensembl_gene_id: YMR119W-A
symbol: YMR119W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized membrane protein YMR119W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 3' end of ORF ASI1/YMR119W.


ensembl_gene_id: YMR120C
symbol: ADE17
gene_biotype: protein_coding
description:
  Phosphoribosylaminoimidazolecarboxamide formyltransferase; Enzyme of 'de novo' purine biosynthesis; contains both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities; ADE17 has a paralog, ADE16, that arose from the whole genome duplication; ade16 ade17 mutants require adenine and histidine; Belongs to the PurH family.


ensembl_gene_id: YMR121C
symbol: RPL15B
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L15B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15B has a paralog, RPL15A, that arose from the whole genome duplication; relocalizes from nucleus to nucleolus upon DNA replication stress.


ensembl_gene_id: YMR122C
symbol: YMR122C
gene_biotype: protein_coding
description:
  Uncharacterized protein YMR122C; Putative protein of unknown function; conserved among S. cerevisiae strains; YMR122C is not an essential gene.


ensembl_gene_id: YMR122W-A
symbol: YMR122W-A
gene_biotype: protein_coding
description:
  Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and endoplasmic reticulum.


ensembl_gene_id: YMR123W
symbol: PKR1
gene_biotype: protein_coding
description:
  V-ATPase assembly factor; functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0); protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YMR124W
symbol: EPO1
gene_biotype: protein_coding
description:
  Uncharacterized protein YMR124W; Protein involved in septin-ER tethering; interacts with ER membrane protein, Scs2p, and Shs1p, a septin ring component, at bud neck to create ER diffusion barrier; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W has a paralog, YLR031W, that arose from the whole genome duplication.


ensembl_gene_id: YMR125W
symbol: STO1
gene_biotype: protein_coding
description:
  Large subunit of the nuclear mRNA cap-binding protein complex; interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80; Belongs to the NCBP1 family.


ensembl_gene_id: YMR126C
symbol: DLT1
gene_biotype: protein_coding
description:
  Defect at low temperature protein 1; Protein of unknown function; mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA); Belongs to the DLT1 family.


ensembl_gene_id: YMR127C
symbol: SAS2
gene_biotype: protein_coding
description:
  Histone acetyltransferase (HAT) catalytic subunit of the SAS complex; acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family; other members are Sas4p and Sas5p.


ensembl_gene_id: YMR128W
symbol: ECM16
gene_biotype: protein_coding
description:
  Essential DEAH-box ATP-dependent RNA helicase specific to U3 snoRNP; predominantly nucleolar in distribution; required for 18S rRNA synthesis.


ensembl_gene_id: YMR129W
symbol: POM152
gene_biotype: protein_coding
description:
  Nucleoporin POM152; Glycoprotein subunit of transmembrane ring of nuclear pore complex; contributes to nucleocytoplasmic transport, nuclear pore complex (NPC) biogenesis and spindle pole body duplication; homologous to human NUP210.


ensembl_gene_id: YMR130W
symbol: YMR130W
gene_biotype: protein_coding
description:
  Putative protein of unknown function; YMR130W is not an essential gene; Belongs to the HAD-like hydrolase superfamily.


ensembl_gene_id: YMR131C
symbol: RRB1
gene_biotype: protein_coding
description:
  Ribosome assembly protein RRB1; Specific chaperone for ribosomal protein Rpl3p; binds to nascent Rpl3p during translation; essential gene.


ensembl_gene_id: YMR132C
symbol: JLP2
gene_biotype: protein_coding
description:
  Protein of unknown function; contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein); Belongs to the CCDC25 family.


ensembl_gene_id: YMR133W
symbol: REC114
gene_biotype: protein_coding
description:
  Protein involved in early stages of meiotic recombination; possibly involved in the coordination of recombination and meiotic division; mutations lead to premature initiation of the first meiotic division.


ensembl_gene_id: YMR134W
symbol: ERG29
gene_biotype: protein_coding
description:
  Uncharacterized protein YMR134W; Protein of unknown function involved in ergosterol biosynthesis; conditional mutants produce less ergosterol, display impaired oxygen consumption, respiratory growth, mitochondrial iron utilization, and are more sensitive to oxidative stress; mutant bm-8 has a growth defect on iron-limited medium that is complemented by overexpression of Yfh1p; protein localizes to the cytoplasm, ER and nuclear envelope; highly conserved in ascomycetes.


ensembl_gene_id: YMR135C
symbol: GID8
gene_biotype: protein_coding
description:
  Glucose-induced degradation protein 8; Subunit of GID Complex, binds strongly to central component Vid30p; GID Complex is involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; recruits Rmd5p, Fyv10 and Vid28p to GID Complex; contains LisH, CTLH, and CRA domains that mediate binding to Vid30p (LisH) and Rmd5p and Vid28p (CTLH and CRA); dosage-dependent regulator of START.


ensembl_gene_id: YMR135W-A
symbol: YMR135W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YMR135W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YMR136W
symbol: GAT2
gene_biotype: protein_coding
description:
  Protein containing GATA family zinc finger motifs; similar to Gln3p and Dal80p; expression repressed by leucine.


ensembl_gene_id: YMR137C
symbol: PSO2
gene_biotype: protein_coding
description:
  DNA cross-link repair protein PSO2/SNM1; Nuclease required for DNA single- and double-strand break repair; acts at a post-incision step in repair of breaks that result from interstrand cross-links produced by a variety of mono- and bi-functional psoralen derivatives; induced by UV-irradiation; forms nuclear foci upon DNA replication stress; Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.


ensembl_gene_id: YMR138W
symbol: CIN4
gene_biotype: protein_coding
description:
  GTP-binding protein involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl; regulated by the GTPase-activating protein, Cin2p, the human retinitis pigmentosa 2 (RP2) homolog.


ensembl_gene_id: YMR139W
symbol: RIM11
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase RIM11/MSD1; Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress; RIM11 has a paralog, MRK1, that arose from the whole genome duplication; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.


ensembl_gene_id: YMR140W
symbol: SIP5
gene_biotype: protein_coding
description:
  Protein of unknown function; interacts with both the Reg1p/Glc7p phosphatase and the Snf1p kinase; forms cytoplasmic foci upon DNA replication stress; Belongs to the SIP5 family.


ensembl_gene_id: YMR141C
symbol: YMR141C
gene_biotype: protein_coding
description:
  Uncharacterized protein YMR141C; Putative protein of unknown function; conserved among S. cerevisiae strains; YMR141C is not an essential gene.


ensembl_gene_id: YMR141W-A
symbol: YMR141W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YMR141W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene RPL13B/YMR142C.


ensembl_gene_id: YMR142C
symbol: RPL13B
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L13B; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13B has a paralog, RPL13A, that arose from the whole genome duplication.


ensembl_gene_id: YMR143W
symbol: RPS16A
gene_biotype: protein_coding
description:
  Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S16 and bacterial S9; RPS16A has a paralog, RPS16B, that arose from the whole genome duplication.


ensembl_gene_id: YMR144W
symbol: FDO1
gene_biotype: protein_coding
description:
  Uncharacterized protein YMR144W; Protein involved in directionality of mating type switching; acts with Fkh1p to control which donor mating-type locus is inserted into MAT locus during mating type switching; localized to the nucleus; not an essential gene.


ensembl_gene_id: YMR145C
symbol: NDE1
gene_biotype: protein_coding
description:
  Mitochondrial external NADH dehydrogenase; type II NAD(P)H:quinone oxidoreductase that catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p provide cytosolic NADH to the mitochondrial respiratory chain; NDE1 has a paralog, NDE2, that arose from the whole genome duplication.


ensembl_gene_id: YMR146C
symbol: TIF34
gene_biotype: protein_coding
description:
  eIF3i subunit of the eukaryotic translation initiation factor 3 (eIF3); subunit of the core complex of eIF3; essential for translation; stimulates rate of ribosomal scanning during translation reinitiation; eIF3 is also involved in programmed stop codon readthrough.


ensembl_gene_id: YMR147W
symbol: YMR147W
gene_biotype: protein_coding
description:
  Uncharacterized protein YMR147W; Putative protein of unknown function; SWAT-GFP and mCherry fusion proteins localize to the cell periphery.


ensembl_gene_id: YMR148W
symbol: OSW5
gene_biotype: protein_coding
description:
  Outer spore wall protein 5; Protein of unknown function with possible role in spore wall assembly; predicted to contain an N-terminal transmembrane domain; osw5 null mutant spores exhibit increased spore wall permeability and sensitivity to beta-glucanase digestion; Belongs to the OSW5 family.


ensembl_gene_id: YMR149W
symbol: SWP1
gene_biotype: protein_coding
description:
  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit SWP1; Delta subunit of the oligosaccharyl transferase glycoprotein complex; complex is required for N-linked glycosylation of proteins in the endoplasmic reticulum; Belongs to the SWP1 family.


ensembl_gene_id: YMR150C
symbol: IMP1
gene_biotype: protein_coding
description:
  Catalytic subunit of mitochondrial inner membrane peptidase complex; required for maturation of mitochondrial proteins of the intermembrane space; complex contains two catalytic subunits (Imp1p and Imp2p that differ in substrate specificty) and Som1p.


ensembl_gene_id: YMR151W
symbol: YIM2
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YIM2; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1.


ensembl_gene_id: YMR152W
symbol: YIM1
gene_biotype: protein_coding
description:
  Protein of unknown function; null mutant displays sensitivity to DNA damaging agents; may have a role in lipid metabolism, based on localization to lipid droplets; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YMR153C-A
symbol: YMR153C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YMR153C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps 3' end of verified gene NUP53/YMR153W.


ensembl_gene_id: YMR153W
symbol: NUP53
gene_biotype: protein_coding
description:
  FG-nucleoporin component of central core of nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes directly to nucleocytoplasmic transport; involved in regulation of transcription and mitosis; induces membrane tubulation, which may contribute to nuclear pore assembly; NUP53 has a paralog, ASM4, that arose from the whole genome duplication.


ensembl_gene_id: YMR154C
symbol: RIM13
gene_biotype: protein_coding
description:
  Calpain-like cysteine protease; involved in proteolytic activation of Rim101p in response to alkaline pH; localizes to punctate structures in alkaline conditions and in vps4 mutant; has similarity to A. nidulans palB.


ensembl_gene_id: YMR155W
symbol: YMR155W
gene_biotype: protein_coding
description:
  Uncharacterized membrane protein YMR155W; Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen.


ensembl_gene_id: YMR156C
symbol: TPP1
gene_biotype: protein_coding
description:
  DNA 3'-phosphatase; functions in repair of endogenous damage of double-stranded DNA, activity is specific for removal of 3' phosphates at strand breaks; similar to the l-2-haloacid dehalogenase superfamily; homolog of human polynucleotide kinase/3'-phosphatase.


ensembl_gene_id: YMR157C
symbol: AIM36
gene_biotype: protein_coding
description:
  Protein of unknown function; null mutant displays reduced respiratory growth and elevated frequency of mitochondrial genome loss; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies.


ensembl_gene_id: YMR158C-A
symbol: YMR158C-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YMR158C-A; Putative protein of unknown function; may contain a lipid attachment site; YMR158C-A is not an essential gene.


ensembl_gene_id: YMR158W-B
symbol: YMR158W-B
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YMR158W-B; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene ATG16/YMR159C.


ensembl_gene_id: YMR159C
symbol: ATG16
gene_biotype: protein_coding
description:
  Conserved protein involved in autophagy; interacts with Atg12p-Atg5p conjugates to form Atg12p-Atg5p-Atg16p multimers, which binds to membranes and localizes to the pre-autophagosomal structure and are required for autophagy; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress.


ensembl_gene_id: YMR160W
symbol: YMR160W
gene_biotype: protein_coding
description:
  Uncharacterized protein YMR160W; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole; mutant has enhanced sensitivity to overexpression of mutant huntingtin; YMR160W is not an essential gene; relative distribution within the vacuolar membrane changes upon DNA replication stress.


ensembl_gene_id: YMR161W
symbol: HLJ1
gene_biotype: protein_coding
description:
  Protein HLJ1; Co-chaperone for Hsp40p; anchored in the ER membrane; with its homolog Ydj1p promotes ER-associated protein degradation (ERAD) of integral membrane substrates; similar to E. coli DnaJ.


ensembl_gene_id: YMR162C
symbol: DNF3
gene_biotype: protein_coding
description:
  Probable phospholipid-transporting ATPase DNF3; Trans-golgi network aminophospholipid translocase (flippase); type 4 P-type ATPase; involved in phospholipid translocation, contributing to the maintenance of membrane lipid asymmetry in post-Golgi secretory vesicles; role in protein trafficking between the Golgi and endosomal system; localizes to the trans-Golgi network; localizes to the shmoo tip where it has a redundant role in the cellular response to mating pheromone.


ensembl_gene_id: YMR163C
symbol: INP2
gene_biotype: protein_coding
description:
  Inheritance of peroxisomes protein 2; Peroxisome-specific receptor important for peroxisome inheritance; co-fractionates with peroxisome membranes and co-localizes with peroxisomes in vivo; physically interacts with the myosin V motor Myo2p; INP2 is not an essential gene.


ensembl_gene_id: YMR164C
symbol: MSS11
gene_biotype: protein_coding
description:
  Transcription activator MSS11; Transcription factor; involved in regulation of invasive growth and starch degradation; controls the activation of FLO11 and STA2 in response to nutritional signals; forms a heterodimer with Flo8p that interacts with the Swi/Snf complex during transcriptional activation of FLO1, FLO11, and STA1.


ensembl_gene_id: YMR165C
symbol: PAH1
gene_biotype: protein_coding
description:
  Phosphatidic acid phosphohydrolase 1; Mg2+-dependent phosphatidate (PA) phosphatase; dephosphorylates PA to yield diacylglycerol; regulates phospholipid synthesis, nuclear/ER membrane growth, lipid droplet formation, triacylglycerol synthesis, vacuolar homeostasis and cell wall integrity; phosphorylated by Pho85p/Pho80p, Cdc28p/Cyclin B, PKA, PKC, and CKII, regulating activity, localization, and proteosomal degradation; homolog of mammalian lipins 1 and 2; human homologs LPIN1, LPIN2, LPIN3 complement the null.


ensembl_gene_id: YMR166C
symbol: MME1
gene_biotype: protein_coding
description:
  Mitochondrial magnesium exporter 1; Transporter of the mitochondrial inner membrane that exports magnesium; involved in mitochondrial Mg2+ homeostasis; has similarity to human mitochondrial ATP-Mg/Pi carriers.


ensembl_gene_id: YMR167W
symbol: MLH1
gene_biotype: protein_coding
description:
  Protein required for mismatch repair in mitosis and meiosis; also required for crossing over during meiosis; forms a complex with Pms1p and Msh2p-Msh3p during mismatch repair; human homolog is associated with hereditary non-polyposis colon cancer; Belongs to the DNA mismatch repair MutL/HexB family.


ensembl_gene_id: YMR168C
symbol: CEP3
gene_biotype: protein_coding
description:
  Essential kinetochore protein; component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain.


ensembl_gene_id: YMR169C
symbol: ALD3
gene_biotype: protein_coding
description:
  Cytoplasmic aldehyde dehydrogenase; involved in beta-alanine synthesis; uses NAD+ as the preferred coenzyme; very similar to Ald2p; expression is induced by stress and repressed by glucose.


ensembl_gene_id: YMR170C
symbol: ALD2
gene_biotype: protein_coding
description:
  Cytoplasmic aldehyde dehydrogenase; involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p.


ensembl_gene_id: YMR171C
symbol: EAR1
gene_biotype: protein_coding
description:
  Protein EAR1; Specificity factor required for Rsp5p-dependent ubiquitination; also required for sorting of specific cargo proteins at the multivesicular body; mRNA is targeted to the bud via the mRNA transport system involving She2p.


ensembl_gene_id: YMR172C-A
symbol: YMR172C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized membrane protein YMR172C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps 3' end of ORF HOT1/YMR172W.


ensembl_gene_id: YMR172W
symbol: HOT1
gene_biotype: protein_coding
description:
  High-osmolarity-induced transcription protein 1; Transcription factor for glycerol biosynthetic genes; required for the transient induction of glycerol biosynthetic genes GPD1 and GPP2 in response to high osmolarity; targets Hog1p to osmostress responsive promoters; has similarity to Msn1p and Gcr1p; Belongs to the HOT1 family.


ensembl_gene_id: YMR173W
symbol: DDR48
gene_biotype: protein_coding
description:
  Stress protein DDR48; DNA damage-responsive protein; expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YMR173W-A
symbol: YMR173W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized membrane protein YMR173W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene DDR48/YML173W.


ensembl_gene_id: YMR174C
symbol: PAI3
gene_biotype: protein_coding
description:
  Cytoplasmic proteinase A (Pep4p) inhibitor; dependent on Pbs2p and Hog1p protein kinases for osmotic induction; intrinsically unstructured, N-terminal half becomes ordered in the active site of proteinase A upon contact.


ensembl_gene_id: YMR175W
symbol: SIP18
gene_biotype: protein_coding
description:
  Protein SIP18; Phospholipid-binding hydrophilin; essential to overcome desiccation-rehydration process; expression is induced by osmotic stress; SIP18 has a paralog, GRE1, that arose from the whole genome duplication.


ensembl_gene_id: YMR176W
symbol: ECM5
gene_biotype: protein_coding
description:
  Protein ECM5; Subunit of the Snt2C complex; physically associates with Snt2p and Rpd3p; along with Snt2p, recruits Rpd3p to a small number of promoters; also colocalizes with Snt2p, independently of Rpd3p, to promoters of stress response genes in response to oxidative stress; contains ATP/GTP-binding site motif A; null mutant exhibits increased cellular volume, large drooping buds with elongated necks; relative distribution to the nucleus increases upon DNA replication stress.


ensembl_gene_id: YMR177W
symbol: MMT1
gene_biotype: protein_coding
description:
  Putative metal transporter involved in mitochondrial iron accumulation; MMT1 has a paralog, MMT2, that arose from the whole genome duplication.


ensembl_gene_id: YMR178W
symbol: YMR178W
gene_biotype: protein_coding
description:
  Uncharacterized protein YMR178W; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; YMR178W is not an essential gene; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YMR179W
symbol: SPT21
gene_biotype: protein_coding
description:
  Protein with a role in transcriptional silencing; required for normal transcription at several loci including HTA2-HTB2 and HHF2-HHT2, but not required at the other histone loci; functionally related to Spt10p; localizes to nuclear foci that become diffuse upon DNA replication stress.


ensembl_gene_id: YMR180C
symbol: CTL1
gene_biotype: protein_coding
description:
  RNA 5'-triphosphatase, localizes to both the nucleus and cytoplasm; CTL1 has a paralog, CET1, that arose from the whole genome duplication; Belongs to the fungal TPase family.


ensembl_gene_id: YMR181C
symbol: YMR181C
gene_biotype: protein_coding
description:
  Uncharacterized protein YMR181C; Protein of unknown function; mRNA transcribed as part of a bicistronic transcript with a predicted transcriptional repressor RGM1/YMR182C; mRNA is destroyed by nonsense-mediated decay (NMD); not an essential gene; YMR181C has a paralog, YPL229W, that arose from the whole genome duplication.


ensembl_gene_id: YMR182C
symbol: RGM1
gene_biotype: protein_coding
description:
  Probable transcription repressor protein RGM1; Putative zinc finger DNA binding transcription factor; contains two N-terminal C2H2 zinc fingers and C-terminal proline rich domain; overproduction impairs cell growth and induces expression of genes involved in monosaccharide catabolism and aldehyde metabolism; regulates expression of of Y' telomeric elements and subtelomeric COS genes; relocalizes to the cytosol in response to hypoxia; RGM1 has a paralog, USV1, that arose from the whole genome duplication.


ensembl_gene_id: YMR183C
symbol: SSO2
gene_biotype: protein_coding
description:
  Protein SSO2; Plasma membrane t-SNARE; involved in fusion of secretory vesicles at the plasma membrane; syntaxin homolog that is functionally redundant with Sso1p; SSO2 has a paralog, SSO1, that arose from the whole genome duplication.


ensembl_gene_id: YMR184W
symbol: ADD37
gene_biotype: protein_coding
description:
  Alpha1-proteinase inhibitor-degradation deficient protein 37; Protein of unknown function; involved in ER-associated protein degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YMR184W is not an essential gene; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YMR185W
symbol: RTP1
gene_biotype: protein_coding
description:
  RNA polymerase II assembly factor RTP1; Protein required for the nuclear import and biogenesis of RNA pol II; conflicting evidence on whether null mutant is viable with elongated buds, or inviable; interacts with Rpb2, Rpb3, Nup116p, Nup100p and components of the R2TP complex (Rvb1p, Rvb2p, Pih1p); similar to human TMCO7 gene.


ensembl_gene_id: YMR186W
symbol: HSC82
gene_biotype: protein_coding
description:
  ATP-dependent molecular chaperone HSC82; Cytoplasmic chaperone of the Hsp90 family; plays a role in determining prion variants; redundant in function and nearly identical with Hsp82p, and together they are essential; expressed constitutively at 10-fold higher basal levels than HSP82 and induced 2-3 fold by heat shock; contains two acid-rich unstructured regions that promote the solubility of chaperone-substrate complexes; HSC82 has a paralog, HSP82, that arose from the whole genome duplication.


ensembl_gene_id: YMR189W
symbol: GCV2
gene_biotype: protein_coding
description:
  P subunit of the mitochondrial glycine decarboxylase complex; glycine decarboxylase is required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of 5,10-methylene-THF in the cytoplasm.


ensembl_gene_id: YMR190C
symbol: SGS1
gene_biotype: protein_coding
description:
  ATP-dependent helicase SGS1; RecQ family nucleolar DNA helicase; role in genome integrity maintenance, chromosome synapsis, meiotic joint molecule/crossover formation; stimulates activity of Top3p; rapidly lost in response to rapamycin in Rrd1p-dependent manner; forms nuclear foci upon DNA replication stress; yeast SGS1 complements mutations in human homolog BLM implicated in Bloom syndrome; also similar to human WRN implicated in Werner syndrome; human BLM and WRN can each complement yeast null mutant; Belongs to the helicase family. RecQ subfamily.


ensembl_gene_id: YMR191W
symbol: SPG5
gene_biotype: protein_coding
description:
  Stationary phase protein 5; Protein required for proteasome assembly during quiescence; binds to base of the proteasome regulartory particle; required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources.


ensembl_gene_id: YMR192W
symbol: GYL1
gene_biotype: protein_coding
description:
  Probable GTPase-activating protein GYL1; Putative GTPase activating protein (GAP) with a role in exocytosis; stimulates Gyp5p GAP activity on Ypt1p, colocalizes with Gyp5p at sites of polarized growth; interacts with Gyp5p, Rvs161p, and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; increases in abundance and relocalizes from bud neck to cytoplasm upon DNA replication stress; GYL1 has a paralog, GYP5, that arose from the whole genome duplication.


ensembl_gene_id: YMR193C-A
symbol: YMR193C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YMR193C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YMR193W
symbol: MRPL24
gene_biotype: protein_coding
description:
  Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene.


ensembl_gene_id: YMR194C-A
symbol: YMR194C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YMR194C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YMR194C-B
symbol: CMC4
gene_biotype: protein_coding
description:
  Cx9C motif-containing protein 4, mitochondrial; Protein that localizes to the mitochondrial intermembrane space; localizes via the Mia40p-Erv1p system; contains twin cysteine-x(9)-cysteine motifs; Belongs to the CMC4 family.


ensembl_gene_id: YMR194W
symbol: RPL36A
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L36A; N-terminally acetylated; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L36, no bacterial homolog; RPL36A has a paralog, RPL36B, that arose from the whole genome duplication.


ensembl_gene_id: YMR195W
symbol: ICY1
gene_biotype: protein_coding
description:
  Interacting with cytoskeleton protein 1; Protein of unknown function; required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation; ICY1 has a paralog, ICY2, that arose from the whole genome duplication.


ensembl_gene_id: YMR196W
symbol: YMR196W
gene_biotype: protein_coding
description:
  Uncharacterized protein YMR196W; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR196W is not an essential gene.


ensembl_gene_id: YMR197C
symbol: VTI1
gene_biotype: protein_coding
description:
  t-SNARE VTI1; Protein involved in cis-Golgi membrane traffic; v-SNARE that interacts with two t-SNARES, Sed5p and Pep12p; required for multiple vacuolar sorting pathways; human homolog VTI1A can complement yeast null mutant; Belongs to the VTI1 family.


ensembl_gene_id: YMR198W
symbol: CIK1
gene_biotype: protein_coding
description:
  Spindle pole body-associated protein CIK1; Kinesin-associated protein; required for both karyogamy and mitotic spindle organization, interacts stably and specifically with Kar3p and may function to target this kinesin to a specific cellular role; locus encodes a long and short transcript with differing functions; CIK1 has a paralog, VIK1, that arose from the whole genome duplication.


ensembl_gene_id: YMR199W
symbol: CLN1
gene_biotype: protein_coding
description:
  G1/S-specific cyclin CLN1; G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p); CLN1 has a paralog, CLN2, that arose from the whole genome duplication; cell cycle arrest phenotype of the cln1 cln2 cln3 triple null mutant is complemented by any of human cyclins CCNA2, CCNB1, CCNC, CCND1, or CCNE1.


ensembl_gene_id: YMR200W
symbol: ROT1
gene_biotype: protein_coding
description:
  Protein ROT1; Molecular chaperone involved in protein folding in ER; mutation causes defects in cell wall synthesis and lysis of autophagic bodies, suppresses tor2 mutations, and is synthetically lethal with kar2-1 and with rot2 mutations; involved in N-linked glycosylation and O-mannosylation; transmembrane helix Ser250 is essential for Rot1p to interact with other membrane components and exert its functional role, avoiding exposure of Ser H-bonding group at lipid-exposed surface.


ensembl_gene_id: YMR201C
symbol: RAD14
gene_biotype: protein_coding
description:
  Protein that recognizes and binds damaged DNA during NER; subunit of Nucleotide Excision Repair Factor 1 (NEF1); contains zinc finger motif; homolog of human XPA protein; NER stands for nucleotide excision repair.


ensembl_gene_id: YMR202W
symbol: ERG2
gene_biotype: protein_coding
description:
  C-8 sterol isomerase; catalyzes isomerization of delta-8 double bond to delta-7 position at an intermediate step in ergosterol biosynthesis; transcriptionally down-regulated when ergosterol is in excess; mutation is functionally complemented by human EBP.


ensembl_gene_id: YMR203W
symbol: TOM40
gene_biotype: protein_coding
description:
  Mitochondrial import receptor subunit TOM40; Component of the TOM (translocase of outer membrane) complex; responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore; pre-Tom40p is phosphorylated by PKA, which impairs its import into mitochondria under non-respiratory conditions.


ensembl_gene_id: YMR204C
symbol: INP1
gene_biotype: protein_coding
description:
  Peripheral membrane protein of peroxisomes; involved in peroxisomal inheritance; recruitment to peroxisomes is mediated by interaction with Pex3p at the peroxisomal membrane.


ensembl_gene_id: YMR205C
symbol: PFK2
gene_biotype: protein_coding
description:
  Beta subunit of heterooctameric phosphofructokinase; involved in glycolysis; indispensable for anaerobic growth; activated by fructose-2,6-bisphosphate and AMP; mutation inhibits glucose induction of cell cycle-related genes; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.


ensembl_gene_id: YMR206W
symbol: YMR206W
gene_biotype: protein_coding
description:
  Uncharacterized protein YMR206W; Putative protein of unknown function; not an essential gene; YMR206W has a paralog, YNR014W, that arose from the whole genome duplication.


ensembl_gene_id: YMR207C
symbol: HFA1
gene_biotype: protein_coding
description:
  Acetyl-CoA carboxylase, mitochondrial; Mitochondrial acetyl-coenzyme A carboxylase; catalyzes production of malonyl-CoA in mitochondrial fatty acid biosynthesis; relocalizes from mitochondrion to cytoplasm upon DNA replication stress; genetic and comparative analysis suggests that translation begins at a non-canonical (Ile) start codon at -372 relative to the annotated start codon.


ensembl_gene_id: YMR208W
symbol: ERG12
gene_biotype: protein_coding
description:
  Mevalonate kinase; acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate; human MVK functionally complements the lethality of the erg12 null mutation.


ensembl_gene_id: YMR209C
symbol: YMR209C
gene_biotype: protein_coding
description:
  Uncharacterized protein YMR209C; Putative S-adenosylmethionine-dependent methyltransferase; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively; YMR209C is not an essential gene.


ensembl_gene_id: YMR210W
symbol: MGL2
gene_biotype: protein_coding
description:
  Putative esterase YMR210W; Monoacylglycerol lipase; palmitoyl monoacylglycerol is the preferred substrate; role in triacylglycerol catabolism; minor role in medium-chain fatty acid ethyl ester biosynthesis; contains an alpha/beta hydrolase domain and a typical lipase motif; has similarity to acyltransferases, Eeb1p and Eht1p, and human ABHD1.


ensembl_gene_id: YMR211W
symbol: DML1
gene_biotype: protein_coding
description:
  Essential protein involved in mtDNA inheritance; may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family; Belongs to the misato family.


ensembl_gene_id: YMR212C
symbol: EFR3
gene_biotype: protein_coding
description:
  Protein required for Stt4-containing PI kinase complex localization; required for Stt4-containing phosphoinositide (PI) kinase patch assembly at the plasma membrane; recruited to the plasma membrane via a conserved basic patch near its N-terminus; exhibits synthetic lethal genetic interactions with PHO85; has sequence similarity to the Drosophila rolling blackout (RBO) gene.


ensembl_gene_id: YMR213W
symbol: CEF1
gene_biotype: protein_coding
description:
  Pre-mRNA-splicing factor CEF1; Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p.


ensembl_gene_id: YMR214W
symbol: SCJ1
gene_biotype: protein_coding
description:
  DnaJ-related protein SCJ1; One of several homologs of bacterial chaperone DnaJ; located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins.


ensembl_gene_id: YMR215W
symbol: GAS3
gene_biotype: protein_coding
description:
  Probable 1,3-beta-glucanosyltransferase GAS3; Putative 1,3-beta-glucanosyltransferase; has similarity go other GAS family members; low abundance, possibly inactive member of the GAS family of GPI-containing proteins; localizes to the cell wall; mRNA induced during sporulation.


ensembl_gene_id: YMR216C
symbol: SKY1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase SKY1; SR protein kinase (SRPK); involved in regulating proteins involved in mRNA metabolism and cation homeostasis; similar to human SRPK1.


ensembl_gene_id: YMR217W
symbol: GUA1
gene_biotype: protein_coding
description:
  GMP synthase; highly conserved enzyme that catalyzes the second step in the biosynthesis of GMP from inosine 5'-phosphate (IMP); transcription is not subject to regulation by guanine but is negatively regulated by nutrient starvation; reduction-of-function mutation gua1-G388D causes changes in cellular guanine nucleotide pools, defects in general protein synthesis, and impaired translation of GCN4 mRNA.


ensembl_gene_id: YMR218C
symbol: TRS130
gene_biotype: protein_coding
description:
  Trafficking protein particle complex II-specific subunit 130; Component of transport protein particle (TRAPP) complex II; TRAPPII is a multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p, regulating intra-Golgi and endosome-Golgi traffic.


ensembl_gene_id: YMR219W
symbol: ESC1
gene_biotype: protein_coding
description:
  Silent chromatin protein ESC1; Protein involved in telomeric silencing; required for quiescent cell telomere hypercluster localization at nuclear membrane vicinity; interacts with PAD4-domain of Sir4p.


ensembl_gene_id: YMR220W
symbol: ERG8
gene_biotype: protein_coding
description:
  Phosphomevalonate kinase; an essential cytosolic enzyme that acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate.


ensembl_gene_id: YMR221C
symbol: FMP42
gene_biotype: protein_coding
description:
  Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; physical interaction with Atg27p suggests a possible role in autophagy.


ensembl_gene_id: YMR222C
symbol: FSH2
gene_biotype: protein_coding
description:
  Family of serine hydrolases 2; Putative serine hydrolase that localizes to the cytoplasm; sequence is similar to S. cerevisiae Fsh1p and Fsh3p and the human candidate tumor suppressor OVCA2.


ensembl_gene_id: YMR223W
symbol: UBP8
gene_biotype: protein_coding
description:
  Ubiquitin carboxyl-terminal hydrolase 8; Ubiquitin-specific protease component of the SAGA acetylation complex; required for SAGA (Spt-Ada-Gcn5-Acetyltransferase)-mediated deubiquitination of histone H2B.


ensembl_gene_id: YMR224C
symbol: MRE11
gene_biotype: protein_coding
description:
  Double-strand break repair protein MRE11; Nuclease subunit of the MRX complex with Rad50p and Xrs2p; complex functions in repair of DNA double-strand breaks and in telomere stability; Mre11p associates with Ser/Thr-rich ORFs in premeiotic phase; nuclease activity required for MRX function; widely conserved; forms nuclear foci upon DNA replication stress; Belongs to the MRE11/RAD32 family.


ensembl_gene_id: YMR226C
symbol: YMR226C
gene_biotype: protein_coding
description:
  NADP-dependent 3-hydroxy acid dehydrogenase; NADP(+)-dependent serine dehydrogenase and carbonyl reductase; acts on serine, L-allo-threonine, and other 3-hydroxy acids; green fluorescent protein fusion protein localizes to the cytoplasm and nucleus; may interact with ribosomes, based on co-purification experiments.


ensembl_gene_id: YMR228W
symbol: MTF1
gene_biotype: protein_coding
description:
  Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.


ensembl_gene_id: YMR229C
symbol: RRP5
gene_biotype: protein_coding
description:
  rRNA biogenesis protein RRP5; RNA binding protein involved in synthesis of 18S and 5.8S rRNAs; component of ribosomal small subunit (SSU) processome and 90S preribosome; required for pre-rRNA packaging and compaction of processome into dense terminal balls; part of Mak21p-Noc2p-Rrp5p module that associates with nascent pre-rRNA during transcription with role in biogenesis of large ribosomal subunit; binds single stranded tracts of U's; relocalizes from nucleolus to nucleus upon DNA replication stress.


ensembl_gene_id: YMR230W
symbol: RPS10B
gene_biotype: protein_coding
description:
  Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10B has a paralog, RPS10A, that arose from the whole genome duplication; mutations in the human homolog associated with Diamond-Blackfan anemia.


ensembl_gene_id: YMR231W
symbol: PEP5
gene_biotype: protein_coding
description:
  Histone E3 ligase, component of CORVET membrane tethering complex; peripheral vacuolar membrane protein required for protein trafficking and vacuole biogenesis; interacts with Pep7p; involved in ubiquitination and degradation of excess histones; Belongs to the VPS11 family.


ensembl_gene_id: YMR232W
symbol: FUS2
gene_biotype: protein_coding
description:
  Cell fusion regulator; cytoplasmic protein localized to shmoo tip; required for alignment of parental nuclei before nuclear fusion during mating; contains a Dbl-homology domain; binds specifically with activated Cdc42p.


ensembl_gene_id: YMR233W
symbol: TRI1
gene_biotype: protein_coding
description:
  Protein TRI1; Non-essential sumoylated protein of unknown function; similar to components of human SWI/SNF complex including SMRD3; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, nucleus and nucleolus; TRI1 has a paralog, UAF30, that arose from the whole genome duplication.


ensembl_gene_id: YMR234W
symbol: RNH1
gene_biotype: protein_coding
description:
  Ribonuclease H1; able to bind double-stranded RNAs and RNA-DNA hybrids; associates with RNAse polymerase I.


ensembl_gene_id: YMR235C
symbol: RNA1
gene_biotype: protein_coding
description:
  GTPase activating protein (GAP) for Gsp1p; involved in nuclear transport; Belongs to the RNA1 family.


ensembl_gene_id: YMR236W
symbol: TAF9
gene_biotype: protein_coding
description:
  Subunit (17 kDa) of TFIID and SAGA complexes; involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H3.


ensembl_gene_id: YMR237W
symbol: BCH1
gene_biotype: protein_coding
description:
  Protein BCH1; Member of the ChAPs family (Chs5p-Arf1p-binding proteins); members include Bch1p, Bch2p, Bud7p, and Chs6p; ChAPs family proteins form the exomer complex with Chs5p to mediate export of specific cargo proteins from the Golgi to the plasma membrane; interacts selectively with the activated, GTP-bound form of Arf1p; may interact with ribosomes; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress.


ensembl_gene_id: YMR238W
symbol: DFG5
gene_biotype: protein_coding
description:
  Mannan endo-1,6-alpha-mannosidase DFG5; Putative mannosidase; essential glycosylphosphatidylinositol (GPI)-anchored membrane protein required for cell wall biogenesis in bud formation, involved in filamentous growth, homologous to Dcw1p; Belongs to the glycosyl hydrolase 76 family.


ensembl_gene_id: YMR239C
symbol: RNT1
gene_biotype: protein_coding
description:
  Ribonuclease 3; Nuclear dsRNA-specific ribonuclease (RNase III); involved in rDNA transcription, rRNA processing and U2 snRNA 3' end formation by cleavage of a stem-loop structure at the 3' end of U2 snRNA; involved in polyadenylation-independent transcription termination; involved in the cell wall stress response, regulating the degradation of cell wall integrity and morphogenesis checkpoint genes.


ensembl_gene_id: YMR240C
symbol: CUS1
gene_biotype: protein_coding
description:
  Cold sensitive U2 snRNA suppressor 1; Protein required for assembly of U2 snRNP into the spliceosome; forms a complex with Hsh49p and Hsh155p.


ensembl_gene_id: YMR241W
symbol: YHM2
gene_biotype: protein_coding
description:
  Citrate and oxoglutarate carrier protein; exports citrate from and imports oxoglutarate into the mitochondrion, causing net export of NADPH reducing equivalents; also associates with mt nucleoids and has a role in replication and segregation of the mt genome; Belongs to the mitochondrial carrier (TC 2.A.29) family.


ensembl_gene_id: YMR242C
symbol: RPL20A
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L20A; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20A has a paralog, RPL20B, that arose from the whole genome duplication.


ensembl_gene_id: YMR243C
symbol: ZRC1
gene_biotype: protein_coding
description:
  Zinc/cadmium resistance protein; Vacuolar membrane zinc transporter; transports zinc from cytosol to vacuole for storage; also has role in resistance to zinc shock resulting from sudden influx of zinc into cytoplasm; human ortholog SLC30A10 functions as a Mn transporter and mutations in SLC30A10 cause neurotoxic accumulation of Mn in liver and brain; ZRC1 has a paralog, COT1, that arose from the whole genome duplication; Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.


ensembl_gene_id: YMR244C-A
symbol: COA6
gene_biotype: protein_coding
description:
  Protein involved in cytochrome c oxidase (Complex IV) assembly; involved in delivery of copper to Complex IV; also required for efficient formation of respiratory supercomplexes comprised of Complexes III and IV; localizes to the mitochondrial intermembrane space; ortholog implicated in cardiac defects in zebrafish and human; transcription is induced in response to the DNA-damaging agent MMS; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YMR244W
symbol: YMR244W
gene_biotype: protein_coding
description:
  Uncharacterized protein YMR244W; Putative protein of unknown function; SWAT-GFP fusion protein localizes to the endoplasmic reticulum and vacuole, while mCherry fusion localizes to just the vacuole.


ensembl_gene_id: YMR245W
symbol: YMR245W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YMR245W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YMR246W
symbol: FAA4
gene_biotype: protein_coding
description:
  Long-chain-fatty-acid--CoA ligase 4; Long chain fatty acyl-CoA synthetase; activates fatty acids with a preference for C12:0-C16:0 chain lengths; role in the competitive import of long-chain fatty acids and sphingoid long-chain bases; role in stationary phase survival; localizes to lipid particles and the plasma membrane; role in sphingolipid-to-glycerolipid metabolism; forms cytoplasmic foci upon replication stress; faa1 faa4 double null complemented by any of human ACSBG1, ACSL1, 3, 4, 5, 6, SLC27A2, or 4; Belongs to the ATP-dependent AMP-binding enzyme family.


ensembl_gene_id: YMR247C
symbol: RKR1
gene_biotype: protein_coding
description:
  RING domain E3 ubiquitin ligase; involved in ubiquitin-mediated degradation of non-stop proteins and translationally stalled ER membrane proteins; component of ribosome-bound RQC (ribosome quality control) complex; degrades products of mRNAs lacking a termination codon regardless of a poly(A) tail; functional connections to chromatin modification; homolog of mouse Listerin, mutations in which reported to cause neurodegeneration; Belongs to the LTN1 family.


ensembl_gene_id: YMR247W-A
symbol: YMR247W-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YMR247W-A; Putative protein of unknown function; SWAT-GFP fusion protein localizes to the endoplasmic reticulum and vacuole, while mCherry fusion localizes to just the vacuole.


ensembl_gene_id: YMR250W
symbol: GAD1
gene_biotype: protein_coding
description:
  Glutamate decarboxylase; converts glutamate into gamma-aminobutyric acid (GABA) during glutamate catabolism; involved in response to oxidative stress.


ensembl_gene_id: YMR251W
symbol: GTO3
gene_biotype: protein_coding
description:
  Glutathione S-transferase omega-like 3; Omega class glutathione transferase; putative cytosolic localization.


ensembl_gene_id: YMR251W-A
symbol: HOR7
gene_biotype: protein_coding
description:
  Protein of unknown function; overexpression suppresses Ca2+ sensitivity of mutants lacking inositol phosphorylceramide mannosyltransferases Csg1p and Csh1p; transcription is induced under hyperosmotic stress and repressed by alpha factor; HOR7 has a paralog, DDR2, that arose from the whole genome duplication; To yeast DDR2.


ensembl_gene_id: YMR252C
symbol: YMR252C
gene_biotype: protein_coding
description:
  Uncharacterized protein YMR252C; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YMR252C is not an essential gene.


ensembl_gene_id: YMR253C
symbol: YMR253C
gene_biotype: protein_coding
description:
  Uncharacterized membrane protein YMR253C; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YMR253C is not an essential gene.


ensembl_gene_id: YMR254C
symbol: YMR254C
gene_biotype: protein_coding
description:
  Uncharacterized protein YMR254C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YMR255W
symbol: GFD1
gene_biotype: protein_coding
description:
  mRNA transport factor GFD1; Coiled-coiled protein of unknown function; identified as a high-copy suppressor of a dbp5 mutation; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YMR256C
symbol: COX7
gene_biotype: protein_coding
description:
  Subunit VII of cytochrome c oxidase (Complex IV); Complex IV is the terminal member of the mitochondrial inner membrane electron transport chain.


ensembl_gene_id: YMR257C
symbol: PET111
gene_biotype: protein_coding
description:
  Protein PET111, mitochondrial; Mitochondrial translational activator specific for the COX2 mRNA; located in the mitochondrial inner membrane.


ensembl_gene_id: YMR258C
symbol: ROY1
gene_biotype: protein_coding
description:
  GTPase inhibitor with similarity to F-box proteins; inhibits Ypt52p GTPase activity by preventing Ypt52p from binding GTP; involved in regulating intracellular trafficking; physically interacts with Skp1p.


ensembl_gene_id: YMR259C
symbol: TRM732
gene_biotype: protein_coding
description:
  tRNA (cytidine(32)-2'-O)-methyltransferase non-catalytic subunit TRM732; Protein involved in 2'-O-methylation of C32 of substrate tRNAs; interacts with 2'-O-ribose methyltransferase Trm7p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; non-essential gene; yeast null mutant can be functionally complemented by human THADA, mutations in which have been implicated in epithelial thyroid adenomas, type 2 diabetes, and polycystic ovary syndrome (PCOS).


ensembl_gene_id: YMR260C
symbol: TIF11
gene_biotype: protein_coding
description:
  Translation initiation factor eIF1A; essential protein that forms a complex with Sui1p (eIF1) and the 40S ribosomal subunit and scans for the start codon; C-terminus associates with Fun12p (eIF5B); N terminus interacts with eIF2 and eIF3; Belongs to the eIF-1A family.


ensembl_gene_id: YMR261C
symbol: TPS3
gene_biotype: protein_coding
description:
  Regulatory subunit of trehalose-6-phosphate synthase/phosphatase; involved in synthesis of storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway; TPS3 has a paralog, TSL1, that arose from the whole genome duplication; In the N-terminal section; belongs to the glycosyltransferase 20 family.


ensembl_gene_id: YMR262W
symbol: YMR262W
gene_biotype: protein_coding
description:
  Uncharacterized deoxyribonuclease YMR262W; Protein of unknown function; interacts weakly with Knr4p; YMR262W is not an essential gene.


ensembl_gene_id: YMR263W
symbol: SAP30
gene_biotype: protein_coding
description:
  Transcriptional regulatory protein SAP30; Component of Rpd3L histone deacetylase complex; involved in silencing at telomeres, rDNA, and silent mating-type loci; involved in telomere maintenance; Belongs to the SAP30 family.


ensembl_gene_id: YMR264W
symbol: CUE1
gene_biotype: protein_coding
description:
  Coupling of ubiquitin conjugation to ER degradation protein 1; Ubiquitin-binding protein; ER membrane protein that recruits and integrates the ubiquitin-conjugating enzyme Ubc7p into ER membrane-bound ubiquitin ligase complexes that function in the ER-associated degradation (ERAD) pathway for misfolded proteins; contains a CUE domain that binds ubiquitin to facilitate intramolecular monoubiquitination and to promote diubiquitin elongation, facilitating polyubiquitin chain formation.


ensembl_gene_id: YMR266W
symbol: RSN1
gene_biotype: protein_coding
description:
  Uncharacterized protein RSN1; Membrane protein of unknown function; overexpression suppresses NaCl sensitivity of sro7 mutant cells by restoring sodium pump (Ena1p) localization to the plasma membrane; Belongs to the CSC1 (TC 1.A.17) family.


ensembl_gene_id: YMR267W
symbol: PPA2
gene_biotype: protein_coding
description:
  Mitochondrial inorganic pyrophosphatase; required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate; human ortholog, PPA2, functionally complements the null mutant; mutations in human PPA2 cause a mitochondrial disease resulting in sudden unexpected cardiac arrest in infants; Belongs to the PPase family.


ensembl_gene_id: YMR268C
symbol: PRP24
gene_biotype: protein_coding
description:
  U4/U6 snRNA-associated-splicing factor PRP24; Splicing factor that reanneals snRNPs during spliceosome recycling; reanneals U4 and U6 snRNPs.


ensembl_gene_id: YMR270C
symbol: RRN9
gene_biotype: protein_coding
description:
  RNA polymerase I-specific transcription initiation factor RRN9; Protein involved in promoting high level transcription of rDNA; subunit of UAF (upstream activation factor) for RNA polymerase I.


ensembl_gene_id: YMR271C
symbol: URA10
gene_biotype: protein_coding
description:
  Minor orotate phosphoribosyltransferase (OPRTase) isozyme; catalyzes the fifth enzymatic step in the de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; URA10 has a paralog, URA5, that arose from the whole genome duplication; Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.


ensembl_gene_id: YMR272C
symbol: SCS7
gene_biotype: protein_coding
description:
  Ceramide very long chain fatty acid hydroxylase SCS7; Sphingolipid alpha-hydroxylase; functions in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids, has both cytochrome b5-like and hydroxylase/desaturase domains, not essential for growth; Belongs to the sterol desaturase family. SCS7 subfamily.


ensembl_gene_id: YMR272W-A
symbol: YMR272W-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YMR272W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene SCS7/YMR272C.


ensembl_gene_id: YMR272W-B
symbol: YMR272W-B
gene_biotype: protein_coding
description:
  Uncharacterized protein YMR272W-B; Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; SWAT-GFP fusion protein localizes to the endoplasmic reticulum and vacuole, while mCherry fusion localizes to just the vacuole.


ensembl_gene_id: YMR273C
symbol: ZDS1
gene_biotype: protein_coding
description:
  Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintaining Cdc55p in the cytoplasm where it promotes mitotic entry; involved in mitotic exit through Cdc14p regulation; interacts with silencing proteins at telomeres; has a role in Bcy1p localization; implicated in mRNA nuclear export; ZDS1 has a paralog, ZDS2, that arose from the whole genome duplication.


ensembl_gene_id: YMR274C
symbol: RCE1
gene_biotype: protein_coding
description:
  Type II CAAX prenyl protease; involved in the proteolysis and maturation of Ras and the a-factor mating pheromone; Belongs to the peptidase U48 family.


ensembl_gene_id: YMR275C
symbol: BUL1
gene_biotype: protein_coding
description:
  Ubiquitin ligase-binding protein BUL1; Ubiquitin-binding component of the Rsp5p E3-ubiquitin ligase complex; disruption causes temperature-sensitive growth, overexpression causes missorting of amino acid permeases; BUL1 has a paralog, BUL2, that arose from the whole genome duplication.


ensembl_gene_id: YMR276W
symbol: DSK2
gene_biotype: protein_coding
description:
  Nuclear-enriched ubiquitin-like polyubiquitin-binding protein; required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle; involved in proteolysis; interacts with the proteasome; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YMR277W
symbol: FCP1
gene_biotype: protein_coding
description:
  Carboxy-terminal domain (CTD) phosphatase; essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p); relocalizes to the cytosol in response to hypoxia.


ensembl_gene_id: YMR278W
symbol: PRM15
gene_biotype: protein_coding
description:
  Phosphoribomutase; catalyzes interconversion of ribose-1-phosphate and ribose-5-phosphate; has some phosphoglucomutase activity but primary activity in vivo is phosphoribomutase; contributes to ribose recycling in the pentose phosphate pathway; transcription induced in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; non-essential.


ensembl_gene_id: YMR279C
symbol: YMR279C
gene_biotype: protein_coding
description:
  Uncharacterized transporter YMR279C; Putative boron transporter involved in boron efflux and resistance; overexpression mutant but not null mutant displays boron tolerance phenotype; identified as a heat-induced gene in a high-throughout screen; YMR279C is not an essential gene; YMR279C has a paralog, ATR1, that arose from the whole genome duplication.


ensembl_gene_id: YMR280C
symbol: CAT8
gene_biotype: protein_coding
description:
  Regulatory protein CAT8; Zinc cluster transcriptional activator; necessary for derepression of a variety of genes under non-fermentative growth conditions, active after diauxic shift, binds carbon source responsive elements; relative distribution to the nucleus increases upon DNA replication stress.


ensembl_gene_id: YMR281W
symbol: GPI12
gene_biotype: protein_coding
description:
  N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase; ER membrane protein involved in the second step of GPI anchor assembly; the second step is the de-N-acetylation of the N-acetylglucosaminylphosphatidylinositol intermediate; functional homolog of human PIG-Lp; GPI stands for glycosylphosphatidylinositol; Belongs to the PIGL family.


ensembl_gene_id: YMR282C
symbol: AEP2
gene_biotype: protein_coding
description:
  ATPase expression protein 2, mitochondrial; Mitochondrial protein; likely involved in translation of the mitochondrial OLI1 mRNA; exhibits genetic interaction with the OLI1 mRNA 5'-untranslated leader; Belongs to the AEP2 family.


ensembl_gene_id: YMR283C
symbol: RIT1
gene_biotype: protein_coding
description:
  tRNA A64-2'-O-ribosylphosphate transferase; Initiator methionine 2'-O-ribosyl phosphate transferase; modifies the initiator methionine tRNA at position 64 to distinguish it from elongator methionine tRNA.


ensembl_gene_id: YMR284W
symbol: YKU70
gene_biotype: protein_coding
description:
  ATP-dependent DNA helicase II subunit 1; Subunit of the telomeric Ku complex (Yku70p-Yku80p); involved in telomere length maintenance, structure and telomere position effect; required for localization of telomerase ribonucleoprotein to nucleus via interaction with the TLC1 guide RNA; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair.


ensembl_gene_id: YMR285C
symbol: NGL2
gene_biotype: protein_coding
description:
  RNA exonuclease NGL2; Protein involved in 5.8S rRNA processing; Ccr4p-like RNase required for correct 3'-end formation of 5.8S rRNA at site E; similar to Ngl1p; NGL2 has a paralog, NGL3, that arose from the whole genome duplication.


ensembl_gene_id: YMR287C
symbol: DSS1
gene_biotype: protein_coding
description:
  3'-5' exoribonuclease; component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs.


ensembl_gene_id: YMR288W
symbol: HSH155
gene_biotype: protein_coding
description:
  U2-snRNP associated splicing factor; forms extensive associations with the branch site-3' splice site-3' exon region upon prespliceosome formation; similarity to the mammalian U2 snRNP-associated splicing factor SAP155.


ensembl_gene_id: YMR289W
symbol: ABZ2
gene_biotype: protein_coding
description:
  Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase); catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis.


ensembl_gene_id: YMR290C
symbol: HAS1
gene_biotype: protein_coding
description:
  ATP-dependent RNA helicase; involved in the biogenesis of 40S and 60S ribosome subunits; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles.


ensembl_gene_id: YMR290W-A
symbol: YMR290W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized membrane protein YMR290W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1/YMR290C gene which encodes an ATP-dependent RNA helicase.


ensembl_gene_id: YMR291W
symbol: TDA1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase TDA1; Protein kinase of unknown cellular role; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene; relocalizes from nucleus to cytoplasm upon DNA replication stress.


ensembl_gene_id: YMR292W
symbol: GOT1
gene_biotype: protein_coding
description:
  Homodimeric protein that is packaged into COPII vesicles; cycles between the ER and Golgi; involved in secretory transport but not directly required for aspects of transport assayed in vitro; may influence membrane composition.


ensembl_gene_id: YMR293C
symbol: HER2
gene_biotype: protein_coding
description:
  Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial; Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; required for remodeling of ER caused by Hmg2p overexpression; similar to bacterial GatA glutamyl-tRNA amidotransferase.


ensembl_gene_id: YMR294W
symbol: JNM1
gene_biotype: protein_coding
description:
  Nuclear migration protein JNM1; Component of the yeast dynactin complex; consisting of Nip100p, Jnm1p, and Arp1p; required for proper nuclear migration and spindle partitioning during mitotic anaphase B.


ensembl_gene_id: YMR294W-A
symbol: YMR294W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YMR294W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; substantially overlaps YMR295C; deletion causes sensitivity to unfolded protein response-inducing agents.


ensembl_gene_id: YMR295C
symbol: YMR295C
gene_biotype: protein_coding
description:
  Uncharacterized protein YMR295C; Protein of unknown function that associates with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and bud; not an essential gene; protein abundance increases in response to DNA replication stress; YMR295C has a paralog, YGR273C, that arose from the whole genome duplication.


ensembl_gene_id: YMR296C
symbol: LCB1
gene_biotype: protein_coding
description:
  Component of serine palmitoyltransferase; responsible along with Lcb2p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine.


ensembl_gene_id: YMR297W
symbol: PRC1
gene_biotype: protein_coding
description:
  Vacuolar carboxypeptidase Y (proteinase C, CPY); broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family.


ensembl_gene_id: YMR298W
symbol: LIP1
gene_biotype: protein_coding
description:
  Ceramide synthase subunit; single-span ER membrane protein associated with Lag1p and Lac1p and required for ceramide synthase activity, null mutant grows extremely slowly and is defective in ceramide synthesis; Belongs to the LIP1 family.


ensembl_gene_id: YMR299C
symbol: DYN3
gene_biotype: protein_coding
description:
  Dynein light intermediate chain (LIC); localizes with dynein, null mutant is defective in nuclear migration; Belongs to the dynein light intermediate chain DYN3 family.


ensembl_gene_id: YMR300C
symbol: ADE4
gene_biotype: protein_coding
description:
  Amidophosphoribosyltransferase; Phosphoribosylpyrophosphate amidotransferase (PRPPAT); catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway; also known as amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.


ensembl_gene_id: YMR301C
symbol: ATM1
gene_biotype: protein_coding
description:
  Iron-sulfur clusters transporter ATM1, mitochondrial; Mitochondrial inner membrane ATP-binding cassette (ABC) transporter; exports mitochondrially synthesized precursors of iron-sulfur (Fe/S) clusters to the cytosol; human homolog ABCB7 can complement yeast null mutant; Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.


ensembl_gene_id: YMR302C
symbol: YME2
gene_biotype: protein_coding
description:
  Integral inner mitochondrial membrane protein; role in maintaining mitochondrial nucleoid structure and number; mutants exhibit an increased rate of mitochondrial DNA escape; shows some sequence similarity to exonucleases.


ensembl_gene_id: YMR303C
symbol: ADH2
gene_biotype: protein_coding
description:
  Glucose-repressible alcohol dehydrogenase II; catalyzes the conversion of ethanol to acetaldehyde; involved in the production of certain carboxylate esters; regulated by ADR1.


ensembl_gene_id: YMR304C-A
symbol: YMR304C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized membrane protein YMR304C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 3' end of verified ORF SCW10/YMR305C.


ensembl_gene_id: YMR304W
symbol: UBP15
gene_biotype: protein_coding
description:
  Ubiquitin carboxyl-terminal hydrolase 15; Ubiquitin-specific protease involved in protein deubiquitination; forms a complex with AAA peroxins Pex1p and Pex6p; deubiquitinates mono- and polyubiquitinated forms of Pex5p; deubiquitinates Clb5p, counteracting APC activity, and facilitating both Clb5p accumulation and S phase entry; physically interacts with anaphase-promoting complex/cyclosome (APC/C) activator, Cdh1p; catalytic activity regulated by an N-terminal TRAF-like domain and and C-terminal sequences; Belongs to the peptidase C19 family.


ensembl_gene_id: YMR305C
symbol: SCW10
gene_biotype: protein_coding
description:
  Probable family 17 glucosidase SCW10; Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on mutant phenotype and its regulation by Ste12p; SWC10 has a paralog, SCW4, that arose from the whole genome duplication; Belongs to the glycosyl hydrolase 17 family.


ensembl_gene_id: YMR306C-A
symbol: YMR306C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized membrane protein YMR306C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps 3' end of ORF FKS3/YMR306W.


ensembl_gene_id: YMR306W
symbol: FKS3
gene_biotype: protein_coding
description:
  1,3-beta-glucan synthase component FKS3; Protein involved in spore wall assembly; has similarity to 1,3-beta-D-glucan synthase catalytic subunits Fks1p and Gsc2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Belongs to the glycosyltransferase 48 family.


ensembl_gene_id: YMR307C-A
symbol: YMR307C-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YMR307C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified gene GAS1/YMR307W.


ensembl_gene_id: YMR307W
symbol: GAS1
gene_biotype: protein_coding
description:
  1,3-beta-glucanosyltransferase GAS1; Beta-1,3-glucanosyltransferase; required for cell wall assembly and also has a role in transcriptional silencing; localizes to cell surface via a glycosylphosphatidylinositol (GPI) anchor; also found at nuclear periphery; genetic interactions with histone H3 lysine acetyltransferases GCN5 and SAS3 indicate previously unsuspected functions for Gas1 in DNA damage response and cell cycle regulation; Belongs to the glycosyl hydrolase 72 family.


ensembl_gene_id: YMR308C
symbol: PSE1
gene_biotype: protein_coding
description:
  Importin subunit beta-3; Karyopherin/importin that interacts with the nuclear pore complex; acts as the nuclear import receptor for specific proteins, including Pdr1p, Yap1p, Ste12p, and Aft1p.


ensembl_gene_id: YMR309C
symbol: NIP1
gene_biotype: protein_coding
description:
  eIF3c subunit of the eukaryotic translation initiation factor 3 (eIF3); involved in the assembly of preinitiation complex and start codon selection; eIF3 is also involved in programmed stop codon readthrough.


ensembl_gene_id: YMR310C
symbol: YMR310C
gene_biotype: protein_coding
description:
  Putative methyltransferase; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; not an essential gene; YMR310C has a paralog, YGR283C, that arose from the whole genome duplication; Belongs to the class IV-like SAM-binding methyltransferase superfamily.


ensembl_gene_id: YMR311C
symbol: GLC8
gene_biotype: protein_coding
description:
  Protein GLC8; Regulatory subunit of protein phosphatase 1 (Glc7p); involved in glycogen metabolism and chromosome segregation; proposed to regulate Glc7p activity via conformational alteration; ortholog of the mammalian protein phosphatase inhibitor 2; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YMR312W
symbol: ELP6
gene_biotype: protein_coding
description:
  Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity.


ensembl_gene_id: YMR313C
symbol: TGL3
gene_biotype: protein_coding
description:
  Lipase 3; Bifunctional triacylglycerol lipase and LPE acyltransferase; major lipid particle-localized triacylglycerol (TAG) lipase; catalyzes acylation of lysophosphatidylethanolamine (LPE), a function which is essential for sporulation; protein level and stability of Tgl3p are markedly reduced in the absence of lipid droplets; required with Tgl4p for timely bud formation.


ensembl_gene_id: YMR314W
symbol: PRE5
gene_biotype: protein_coding
description:
  Alpha 6 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress; Belongs to the peptidase T1A family.


ensembl_gene_id: YMR315W
symbol: YMR315W
gene_biotype: protein_coding
description:
  Uncharacterized protein YMR315W; Protein with NADP(H) oxidoreductase activity; transcription is regulated by Stb5p in response to NADPH depletion induced by diamide; promoter contains a putative Stb5p binding site; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YMR316C-A
symbol: YMR316C-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YMR316C-A; Protein of unknown function; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum; mRNA identified as translated by ribosome profiling data; overlaps the verified gene DIA1/YMR316W.


ensembl_gene_id: YMR316C-B
symbol: YMR316C-B
gene_biotype: protein_coding
description:
  Putative uncharacterized membrane protein YMR316C-B; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps 5' end of ORF YMR317W.


ensembl_gene_id: YMR316W
symbol: DIA1
gene_biotype: protein_coding
description:
  Protein of unknown function; involved in invasive and pseudohyphal growth; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern.


ensembl_gene_id: YMR317W
symbol: YMR317W
gene_biotype: protein_coding
description:
  Uncharacterized protein YMR317W; Putative protein of unknown function; has some similarity to sialidase from Trypanosoma; YMR317W is not an essential gene.


ensembl_gene_id: YMR318C
symbol: ADH6
gene_biotype: protein_coding
description:
  NADPH-dependent medium chain alcohol dehydrogenase; has broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YMR320W
symbol: YMR320W
gene_biotype: protein_coding
description:
  Uncharacterized protein YMR320W; Putative protein of unknown function; conserved among S. cerevisiae strains; YMR320W is not an essential gene.


ensembl_gene_id: YMR321C
symbol: YMR321C
gene_biotype: protein_coding
description:
  Putative protein of unknown function; proposed to be a palmitoylated membrane protein; YMR321C has a paralog, SAM4, that arose from a single-locus duplication.


ensembl_gene_id: YMR322C
symbol: SNO4
gene_biotype: protein_coding
description:
  Probable glutathione-independent glyoxalase SNO4; Possible chaperone and cysteine protease; required for transcriptional reprogramming during the diauxic shift and for survival in stationary phase; similar to bacterial Hsp31 and yeast Hsp31p, Hsp32p, and Hsp33p; DJ-1/ThiJ/PfpI superfamily member; predicted involvement in pyridoxine metabolism; induced by mild heat stress and copper deprivation.


ensembl_gene_id: YMR323W
symbol: ERR3
gene_biotype: protein_coding
description:
  Enolase-related protein 3; Enolase, a phosphopyruvate hydratase; catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate; complements the growth defect of an ENO1 ENO2 double mutant in glucose.


ensembl_gene_id: YMR324C
symbol: YMR324C
gene_biotype: protein_coding
description:
  Putative UPF0377 protein YMR324C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; transcription is AZF1 dependent in glycerol-lactate medium and SLT2 dependent in response to the lipid hydroperoxides.


ensembl_gene_id: YMR325W
symbol: PAU19
gene_biotype: protein_coding
description:
  Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions.


ensembl_gene_id: YMR326C
symbol: YMR326C
gene_biotype: protein_coding
description:
  Putative UPF0320 protein YMR326C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the telomere on the right arm of chromosome 13.


ensembl_gene_id: YNL001W
symbol: DOM34
gene_biotype: protein_coding
description:
  Protein that facilitates ribosomal subunit dissociation; Dom34-Hbs1 complex and Rli1p have roles in dissociating inactive ribosomes to facilitate translation restart, particularly ribosomes stalled in 3' UTRs; required for RNA cleavage in no-go decay, but reports conflict on endonuclease activity; Pelota ortholog; protein abundance increases in response to DNA replication stress; DOM34 has a paralog, YCL001W-B, that arose from the whole genome duplication.


ensembl_gene_id: YNL002C
symbol: RLP7
gene_biotype: protein_coding
description:
  Ribosome biogenesis protein RLP7; Nucleolar protein similar to large ribosomal subunit L7 proteins; constituent of 66S pre-ribosomal particles; plays an essential role in processing of precursors to the large ribosomal subunit RNAs; binds junction of ITS2 and ITS2-proximal stem between the 3' end of 5.8S rRNA and the 5' end of 25S rRNA.


ensembl_gene_id: YNL003C
symbol: PET8
gene_biotype: protein_coding
description:
  Putative mitochondrial carrier protein PET8; S-adenosylmethionine transporter of the mitochondrial inner membrane; member of the mitochondrial carrier family; required for biotin biosynthesis and respiratory growth.


ensembl_gene_id: YNL004W
symbol: HRB1
gene_biotype: protein_coding
description:
  Protein HRB1; Poly(A+) RNA-binding protein; key surveillance factor for the selective export of spliced mRNAs from the nucleus to the cytoplasm; preference for intron-containing genes; similar to Npl3p; HRB1 has a paralog, GBP2, that arose from the whole genome duplication.


ensembl_gene_id: YNL006W
symbol: LST8
gene_biotype: protein_coding
description:
  Target of rapamycin complex subunit LST8; Protein required for the transport of Gap1p; required for the transport of amino acid permease Gap1p from the Golgi to the cell surface; component of the TOR signaling pathway; associates with both Tor1p and Tor2p; contains a WD-repeat.


ensembl_gene_id: YNL007C
symbol: SIS1
gene_biotype: protein_coding
description:
  Protein SIS1; Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p; shuttles between cytosol and nucleus; mediates delivery of misfolded proteins into the nucleus for degradation; involved in proteasomal degradation of misfolded cytosolic proteins; protein abundance increases in response to DNA replication stress; polyQ aggregates sequester Sis1p and interfere with clearance of misfolded proteins; similar to bacterial DnaJ proteins and mammalian DnaJB1.


ensembl_gene_id: YNL008C
symbol: ASI3
gene_biotype: protein_coding
description:
  Protein ASI3; Subunit of the inner nuclear membrane Asi ubiquitin ligase complex; Asi complex targets both misfolded proteins of the inner nuclear membrane-associated degradation (INMAD) pathway and regulators of sterol biosynthesis for ubiquitin-mediated degradation; acts with Asi1p and Asi2p to ensure the fidelity of SPS-sensor signaling by targeting latent unprocessed forms of Stp1p and Stp2p, maintaining the repressed state of gene expression in the absence of inducing amino acids.


ensembl_gene_id: YNL009W
symbol: IDP3
gene_biotype: protein_coding
description:
  Peroxisomal NADP-dependent isocitrate dehydrogenase; catalyzes oxidation of isocitrate to alpha-ketoglutarate with the formation of NADP(H+), required for growth on unsaturated fatty acids; IDP3 has a paralog, IDP2, that arose from the whole genome duplication.


ensembl_gene_id: YNL010W
symbol: YNL010W
gene_biotype: protein_coding
description:
  Uncharacterized phosphatase YNL010W; Putative protein of unknown function; similar to phosphoserine phosphatases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; homozygous diploid mutant shows an increase in glycogen accumulation; Belongs to the HAD-like hydrolase superfamily.


ensembl_gene_id: YNL012W
symbol: SPO1
gene_biotype: protein_coding
description:
  Putative meiotic phospholipase SPO1; Meiosis-specific prospore protein; required for meiotic spindle pole body duplication and separation; required to produce bending force necessary for proper prospore membrane assembly during sporulation; has similarity to phospholipase B.


ensembl_gene_id: YNL013C
symbol: YNL013C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YNL013C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF HEF3/YNL014W.


ensembl_gene_id: YNL014W
symbol: HEF3
gene_biotype: protein_coding
description:
  Translational elongation factor EF-3; member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells; HEF3 has a paralog, YEF3, that arose from the whole genome duplication.


ensembl_gene_id: YNL015W
symbol: PBI2
gene_biotype: protein_coding
description:
  Cytosolic inhibitor of vacuolar proteinase B (PRB1); required for efficient vacuole inheritance; with thioredoxin forms protein complex LMA1, which assists in priming SNARE molecules and promotes vacuole fusion; protein abundance increases in response to DNA replication stress; Belongs to the protease inhibitor I9 family.


ensembl_gene_id: YNL016W
symbol: PUB1
gene_biotype: protein_coding
description:
  Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1; Poly (A)+ RNA-binding protein; abundant mRNP-component protein that binds mRNA and is required for stability of many mRNAs; component of glucose deprivation induced stress granules, involved in P-body-dependent granule assembly; implicated in regulation of translation; carries Q/N-rich domain at C- terminus, identified as candidate prion; human homolog Tia1 is critical for normal synaptic plasticity; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YNL017C
symbol: YNL017C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YNL017C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the tRNA ORF tI(AAU)N2.


ensembl_gene_id: YNL018C
symbol: YNL018C
gene_biotype: protein_coding
description:
  Putative protein of unknown function; YNL018C has a paralog, YNL034W, that arose from a segmental duplication; To yeast YNL034w.


ensembl_gene_id: YNL019C
symbol: YNL019C
gene_biotype: protein_coding
description:
  Uncharacterized membrane protein YNL019C; Putative protein of unknown function; expression induced during heat stress; YNL019C has a paralog, YNL033W, that arose from a segmental duplication.


ensembl_gene_id: YNL020C
symbol: ARK1
gene_biotype: protein_coding
description:
  Actin-regulating kinase 1; Serine/threonine protein kinase; involved in regulation of the cortical actin cytoskeleton; involved in control of endocytosis; ARK1 has a paralog, PRK1, that arose from the whole genome duplication.


ensembl_gene_id: YNL021W
symbol: HDA1
gene_biotype: protein_coding
description:
  Histone deacetylase HDA1; Putative catalytic subunit of a class II histone deacetylase complex; role in azole resistance via Hsp90p, and in the heat shock response; Hda1p interacts with the Hda2p-Hda3p subcomplex to form an active tetramer; deletion increases histone H2B, H3 and H4 acetylation; other members of the HDA1 histone deacetylase complex are Hda2p and Hda3p.


ensembl_gene_id: YNL022C
symbol: RCM1
gene_biotype: protein_coding
description:
  rRNA m5C methyltransferase; methylates cytosine at position 2278 of 25S rRNA while Nop2p methylates cytosine at position 2870; contains seven beta-strand methyltransferase motif; localized to the nucleolus; interacts with Trm112p; homolog of NSUN5A, a human gene which is deleted in Williams-Beuren Syndrome.


ensembl_gene_id: YNL023C
symbol: FAP1
gene_biotype: protein_coding
description:
  Protein that binds to Fpr1p; confers rapamycin resistance by competing with rapamycin for Fpr1p binding; accumulates in the nucleus upon treatment of cells with rapamycin; has similarity to D. melanogaster shuttle craft and human NFX1.


ensembl_gene_id: YNL024C
symbol: EFM6
gene_biotype: protein_coding
description:
  Protein-lysine N-methyltransferase EFM6; Putative S-adenosylmethionine-dependent lysine methyltransferase; responsible for modifying Lys-390 in translational elongation factor EF-1 alpha (eEF1A); has seven beta-strand methyltransferase motif; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm.


ensembl_gene_id: YNL024C-A
symbol: KSH1
gene_biotype: protein_coding
description:
  Essential protein suggested to function early in the secretory pathway; inviability is suppressed by overexpression of Golgi protein Tvp23p; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and cytosol respectively; ortholog of human Kish.


ensembl_gene_id: YNL025C
symbol: SSN8
gene_biotype: protein_coding
description:
  Cyclin-like component of the RNA polymerase II holoenzyme; involved in phosphorylation of the RNA polymerase II C-terminal domain; forms a kinase-cyclin pair in the RNAPII holoenzyme with Ssn3p; required for both entry into and execution of the meiotic program; involved in glucose repression and telomere maintenance; cyclin homolog 35% identical to human cyclin C.


ensembl_gene_id: YNL026W
symbol: SAM50
gene_biotype: protein_coding
description:
  Component of the Sorting and Assembly Machinery (SAM) complex; the SAM (or TOB) complex is located in the mitochondrial outer membrane; the complex binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; homologous to bacterial Omp85.


ensembl_gene_id: YNL027W
symbol: CRZ1
gene_biotype: protein_coding
description:
  Transcriptional regulator CRZ1; Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress; can be activated in stochastic pulses of nuclear localization in response to calcium.


ensembl_gene_id: YNL028W
symbol: YNL028W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YNL028W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YNL029C
symbol: KTR5
gene_biotype: protein_coding
description:
  Probable mannosyltransferase KTR5; Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; KTR5 has a paralog, KTR7, that arose from the whole genome duplication.


ensembl_gene_id: YNL030W
symbol: HHF2
gene_biotype: protein_coding
description:
  Histone H4; core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF1); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity.


ensembl_gene_id: YNL031C
symbol: HHT2
gene_biotype: protein_coding
description:
  Histone H3; core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT1); regulated by acetylation, methylation, and phosphorylation; H3K14 acetylation plays an important role in the unfolding of strongly positioned nucleosomes during repair of UV damage.


ensembl_gene_id: YNL032W
symbol: SIW14
gene_biotype: protein_coding
description:
  Inositol phosphatase SIW14; Tyrosine phosphatase involved in actin organization and endocytosis; localized to the cytoplasm.


ensembl_gene_id: YNL033W
symbol: YNL033W
gene_biotype: protein_coding
description:
  Putative protein of unknown function; YNL033W has a paralog, YNL019C, that arose from a segmental duplication; To yeast YNL019c.


ensembl_gene_id: YNL034W
symbol: YNL034W
gene_biotype: protein_coding
description:
  Uncharacterized protein YNL034W; Putative protein of unknown function; not an essential gene; YNL034W has a paralog, YNL018C, that arose from a segmental duplication; To yeast YNL018c.


ensembl_gene_id: YNL035C
symbol: YNL035C
gene_biotype: protein_coding
description:
  Uncharacterized WD repeat-containing protein YNL035C; Nuclear protein of unknown function; relocalizes to the cytosol in response to hypoxia; contains WD-40 domains; not an essential gene; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YNL036W
symbol: NCE103
gene_biotype: protein_coding
description:
  Carbonic anhydrase; metalloenzyme that catalyzes CO2 hydration to bicarbonate, which is an important metabolic substrate, and protons; not expressed under conditions of high CO2, such as inside a growing colony, but transcription is induced in response to low CO2 levels, such as on the colony surface in ambient air; poorly transcribed under aerobic conditions and at an undetectable level under anaerobic conditions; abundance increases in response to DNA replication stress.


ensembl_gene_id: YNL037C
symbol: IDH1
gene_biotype: protein_coding
description:
  Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase; complex catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle; Belongs to the isocitrate and isopropylmalate dehydrogenases family.


ensembl_gene_id: YNL038W
symbol: GPI15
gene_biotype: protein_coding
description:
  Phosphatidylinositol N-acetylglucosaminyltransferase subunit GPI15; Protein involved in the synthesis of GlcNAc-PI; GlcNAc-PI is the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-H protein; GlcNAc-PI stands for N-acetylglucosaminyl phosphatidylinositol.


ensembl_gene_id: YNL039W
symbol: BDP1
gene_biotype: protein_coding
description:
  Essential subunit of RNA polymerase III transcription factor (TFIIIB); TFIIIB is involved in transcription of genes encoding tRNAs, 5S rRNA, U6 snRNA, and other small RNAs.


ensembl_gene_id: YNL040W
symbol: YNL040W
gene_biotype: protein_coding
description:
  Putative alanyl-tRNA editing protein alaX; Protein of unknown function; has strong similarity to alanyl-tRNA synthases from Eubacteria; null mutant displays decreased translation rate and increased readthrough of premature stop codons; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL040W is not an essential gene.


ensembl_gene_id: YNL042W
symbol: BOP3
gene_biotype: protein_coding
description:
  Protein of unknown function; potential Cdc28p substrate; overproduction confers resistance to methylmercury.


ensembl_gene_id: YNL043C
symbol: YNL043C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YNL043C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W.


ensembl_gene_id: YNL044W
symbol: YIP3
gene_biotype: protein_coding
description:
  Prenylated Rab acceptor 1; Protein localized to COPII vesicles; proposed to be involved in ER to Golgi transport; interacts with members of the Rab GTPase family and Yip1p; also interacts with Rtn1p; Belongs to the PRA1 family.


ensembl_gene_id: YNL045W
symbol: LAP2
gene_biotype: protein_coding
description:
  Leucine aminopeptidase 2; Leucyl aminopeptidase yscIV with epoxide hydrolase activity; metalloenzyme containing one zinc atom; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; also known as leukotriene A4 hydrolase.


ensembl_gene_id: YNL046W
symbol: YNL046W
gene_biotype: protein_coding
description:
  Putative protein of unknown function; expression depends on Swi5p; GFP-fusion protein localizes to the endoplasmic reticulum; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO).


ensembl_gene_id: YNL047C
symbol: SLM2
gene_biotype: protein_coding
description:
  Phosphatidylinositol 4,5-bisphosphate-binding protein SLM2; Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm1p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; TORC2 complex substrate and effector; SLM2 has a paralog, SLM1, that arose from the whole genome duplication.


ensembl_gene_id: YNL048W
symbol: ALG11
gene_biotype: protein_coding
description:
  Alpha-1,2-mannosyltransferase; catalyzes sequential addition of the two terminal alpha 1,2-mannose residues to the Man5GlcNAc2-PP-dolichol intermediate during asparagine-linked glycosylation in the ER.


ensembl_gene_id: YNL049C
symbol: SFB2
gene_biotype: protein_coding
description:
  SED5-binding protein 2; Component of the Sec23p-Sfb2p heterodimer of the COPII vesicle coat; required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sfb3p; SFB2 has a paralog, SEC24, that arose from the whole genome duplication.


ensembl_gene_id: YNL052W
symbol: COX5A
gene_biotype: protein_coding
description:
  Subunit Va of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Ap is predominantly expressed during aerobic growth while its isoform Vb (Cox5Bp) is expressed during anaerobic growth; COX5A has a paralog, COX5B, that arose from the whole genome duplication.


ensembl_gene_id: YNL053W
symbol: MSG5
gene_biotype: protein_coding
description:
  Tyrosine-protein phosphatase MSG5; Dual-specificity protein phosphatase; exists in 2 isoforms; required for maintenance of a low level of signaling through the cell integrity pathway, adaptive response to pheromone; regulates and is regulated by Slt2p; dephosphorylates Fus3p; MSG5 has a paralog, SDP1, that arose from the whole genome duplication; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.


ensembl_gene_id: YNL054W
symbol: VAC7
gene_biotype: protein_coding
description:
  Integral vacuolar membrane protein; involved in vacuole inheritance and morphology; activates Fab1p kinase activity under basal conditions and also after hyperosmotic shock.


ensembl_gene_id: YNL055C
symbol: POR1
gene_biotype: protein_coding
description:
  Mitochondrial porin (voltage-dependent anion channel); outer membrane protein required for maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; couples the glutathione pools of the intermembrane space (IMS) and the cytosol; interacts with Om45 and Om14 in the outer membrane; phosphorylated; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YNL056W
symbol: OCA2
gene_biotype: protein_coding
description:
  Tyrosine-protein phosphatase-like protein OCA2; Protein of unknown function; similar to predicted tyrosine phosphatases Oca1p and Siw14p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL056W is not an essential gene.


ensembl_gene_id: YNL057W
symbol: YNL057W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YNL057W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YNL058C
symbol: YNL058C
gene_biotype: protein_coding
description:
  Vacuolar membrane protein YNL058C; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to vacuole; not an essential gene; YNL058C has a paralog, PRM5, that arose from the whole genome duplication.


ensembl_gene_id: YNL059C
symbol: ARP5
gene_biotype: protein_coding
description:
  Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes; promotes nucleosome shifts in the 3 prime direction; Belongs to the actin family.


ensembl_gene_id: YNL061W
symbol: NOP2
gene_biotype: protein_coding
description:
  rRNA m5C methyltransferase; methylates cytosine at position 2870 of 25S rRNA; has an essential function independent of rRNA methylation; contains seven beta-strand methyltransferase motif; essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribosomal particles; rRNA methylation defect and lethality are functionally complemented by human NOP2, a gene upregulated in cancer; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.


ensembl_gene_id: YNL062C
symbol: GCD10
gene_biotype: protein_coding
description:
  tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6; Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p; required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression.


ensembl_gene_id: YNL063W
symbol: MTQ1
gene_biotype: protein_coding
description:
  Mitochondrial MRF1 N(5)-glutamine methyltransferase MTQ1; S-adenosylmethionine-dependent methyltransferase; methylates translational release factor Mrf1p; similar to E.coli PrmC; is not an essential gene.


ensembl_gene_id: YNL064C
symbol: YDJ1
gene_biotype: protein_coding
description:
  Mitochondrial protein import protein MAS5; Type I HSP40 co-chaperone; involved in regulation of HSP90 and HSP70 functions; acts as an adaptor that helps Rsp5p recognize cytosolic misfolded proteins for ubiquitination after heat shock; critical for determining cell size at Start as a function of growth rate; involved in protein translocation across membranes; member of the DnaJ family; chimeric protein in which human p58IPK J domain replaces yeast Ydj1p J domain can complement yeast ydj1 mutant.


ensembl_gene_id: YNL065W
symbol: AQR1
gene_biotype: protein_coding
description:
  Probable transporter AQR1; Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids; AQR1 has a paralog, QDR1, that arose from the whole genome duplication; relocalizes from plasma membrane to cytoplasm upon DNA replication stress.


ensembl_gene_id: YNL066W
symbol: SUN4
gene_biotype: protein_coding
description:
  Probable secreted beta-glucosidase SUN4; Cell wall protein related to glucanases; possibly involved in cell wall septation; member of the SUN family; SUN4 has a paralog, SIM1, that arose from the whole genome duplication.


ensembl_gene_id: YNL067W
symbol: RPL9B
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L9B; homologous to mammalian ribosomal protein L9 and bacterial L6; RPL9B has a paralog, RPL9A, that arose from a single-locus duplication.


ensembl_gene_id: YNL067W-A
symbol: YNL067W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YNL067W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YNL068C
symbol: FKH2
gene_biotype: protein_coding
description:
  Fork head protein homolog 2; Forkhead family transcription factor; rate-limiting activator of replication origins; evolutionarily conserved regulator of lifespan; binds multiple chromosomal elements with distinct specificities, cell cycle dynamics; positively regulates transcriptional elongation; facilitates clustering, activation of early-firing replication origins; negative role in chromatin silencing at HML and HMR; major role in expression of G2/M phase genes; relocalizes to cytosol under hypoxia.


ensembl_gene_id: YNL069C
symbol: RPL16B
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L16B; N-terminally acetylated, binds 5.8 S rRNA; transcriptionally regulated by Rap1p; homologous to mammalian ribosomal protein L13A and bacterial L13; RPL16B has a paralog, RPL16A, that arose from the whole genome duplication.


ensembl_gene_id: YNL070W
symbol: TOM7
gene_biotype: protein_coding
description:
  Mitochondrial import receptor subunit TOM7; Component of the TOM (translocase of outer membrane) complex; responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex; Belongs to the Tom7 family.


ensembl_gene_id: YNL071W
symbol: LAT1
gene_biotype: protein_coding
description:
  Dihydrolipoamide acetyltransferase component (E2) of the PDC; the pyruvate dehydrogenase complex (PDC) catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA.


ensembl_gene_id: YNL072W
symbol: RNH201
gene_biotype: protein_coding
description:
  Ribonuclease H2 catalytic subunit; removes RNA primers during Okazaki fragment synthesis and errant ribonucleotides misincorporated during DNA replication; role in ribonucleotide excision repair; homolog of RNAse HI; related to human AGS4 which causes Aicardi-Goutieres syndrome.


ensembl_gene_id: YNL073W
symbol: MSK1
gene_biotype: protein_coding
description:
  Lysine--tRNA ligase, mitochondrial; Mitochondrial lysine-tRNA synthetase; required for import of both aminoacylated and deacylated forms of tRNA(Lys) into mitochondria and for aminoacylation of mitochondrially encoded tRNA(Lys).


ensembl_gene_id: YNL074C
symbol: MLF3
gene_biotype: protein_coding
description:
  Serine-rich protein of unknown function; predicted to be palmitoylated; overproduction suppresses growth inhibition caused by exposure to immunosuppressant leflunomide; MLF3 has a paralog, VHS2, that arose from the whole genome duplication; To yeast VHS2.


ensembl_gene_id: YNL075W
symbol: IMP4
gene_biotype: protein_coding
description:
  U3 small nucleolar ribonucleoprotein protein IMP4; Component of the SSU processome; SSU processome is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs.


ensembl_gene_id: YNL076W
symbol: MKS1
gene_biotype: protein_coding
description:
  Pleiotropic negative transcriptional regulator; involved in Ras-CAMP and lysine biosynthetic pathways and nitrogen regulation; involved in retrograde (RTG) mitochondria-to-nucleus signaling.


ensembl_gene_id: YNL077W
symbol: APJ1
gene_biotype: protein_coding
description:
  J domain-containing protein APJ1; Chaperone with a role in SUMO-mediated protein degradation; member of the DnaJ-like family; conserved across eukaryotes; overexpression interferes with propagation of the [Psi+] prion; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; forms nuclear foci upon DNA replication stress.


ensembl_gene_id: YNL078W
symbol: NIS1
gene_biotype: protein_coding
description:
  Protein localized in the bud neck at G2/M phase; physically interacts with septins; possibly involved in a mitotic signaling network.


ensembl_gene_id: YNL079C
symbol: TPM1
gene_biotype: protein_coding
description:
  Tropomyosin-1; Major isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; acetylated by the NatB complex and acetylated form binds actin most efficiently; TPM1 has a paralog, TPM2, that arose from the whole genome duplication.


ensembl_gene_id: YNL080C
symbol: EOS1
gene_biotype: protein_coding
description:
  Protein involved in N-glycosylation; deletion mutation confers sensitivity to exidative stress and shows synthetic lethality with mutations in the spindle checkpoint genes BUB3 and MAD1; YNL080C is not an essential gene; Belongs to the EOS1 family.


ensembl_gene_id: YNL081C
symbol: SWS2
gene_biotype: protein_coding
description:
  Putative mitochondrial ribosomal protein of the small subunit; has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency; localizes to vacuole in response to H2O2.


ensembl_gene_id: YNL082W
symbol: PMS1
gene_biotype: protein_coding
description:
  ATP-binding protein required for mismatch repair; required for both mitosis and meiosis; functions as a heterodimer with Mlh1p; binds double- and single-stranded DNA via its N-terminal domain, similar to E. coli MutL.


ensembl_gene_id: YNL083W
symbol: SAL1
gene_biotype: protein_coding
description:
  Truncated non-functional calcium-binding mitochondrial carrier SAL1-1; ADP/ATP transporter; member of the Ca2+-binding subfamily of mitochondrial carriers, with two EF-hand motifs; transport activity of either Sal1p or Pet9p is critical for viability; polymorphic in different S. cerevisiae strains.


ensembl_gene_id: YNL084C
symbol: END3
gene_biotype: protein_coding
description:
  Actin cytoskeleton-regulatory complex protein END3; EH domain-containing protein involved in endocytosis; actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p.


ensembl_gene_id: YNL085W
symbol: MKT1
gene_biotype: protein_coding
description:
  Protein similar to nucleases that forms a complex with Pbp1p; complex may mediate posttranscriptional regulation of HO; involved in propagation of M2 dsRNA satellite of L-A virus; allelic variation affects mitochondrial genome stability, drug resistance, and more; forms cytoplasmic foci upon DNA replication stress; localization to P-bodies under ethanol stress differs between strains.


ensembl_gene_id: YNL086W
symbol: SNN1
gene_biotype: protein_coding
description:
  Subunit of the BLOC-1 complex involved in endosomal maturation; interacts with Msb3p; green fluorescent protein (GFP)-fusion protein localizes to endosomes.


ensembl_gene_id: YNL087W
symbol: TCB2
gene_biotype: protein_coding
description:
  Tricalbin-2; ER protein involved in ER-plasma membrane tethering; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect ER to plasma membrane (PM) and regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1p phosphatase to its substrate PI4P in the PM; contains 3 calcium and lipid binding domains; mRNA is targeted to bud; TCB2 has a paralog, TCB1, that arose from the whole genome duplication.


ensembl_gene_id: YNL088W
symbol: TOP2
gene_biotype: protein_coding
description:
  DNA topoisomerase 2; Topoisomerase II; relieves torsional strain in DNA by cleaving and re-sealing phosphodiester backbone of both positively and negatively supercoiled DNA; cleaves complementary strands; localizes to axial cores in meiosis; required for replication slow zone (RSZ) breakage following Mec1p inactivation; human homolog TOP2A implicated in cancers, and can complement yeast null mutant; Belongs to the type II topoisomerase family.


ensembl_gene_id: YNL089C
symbol: YNL089C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YNL089C; Dubious open reading frame unlikely to encode a functional protein; almost completely overlaps YNL090W/RHO2 which encodes a small GTPase of the Rho/Rac subfamily of Ras-like proteins.


ensembl_gene_id: YNL090W
symbol: RHO2
gene_biotype: protein_coding
description:
  GTP-binding protein RHO2; Non-essential small GTPase of the Rho/Rac family of Ras-like proteins; involved in the establishment of cell polarity and in microtubule assembly.


ensembl_gene_id: YNL091W
symbol: NST1
gene_biotype: protein_coding
description:
  Stress response protein NST1; Protein of unknown function; mediates sensitivity to salt stress; interacts physically with the splicing factor Msl1p and also displays genetic interaction with MSL1.


ensembl_gene_id: YNL092W
symbol: YNL092W
gene_biotype: protein_coding
description:
  Carnosine N-methyltransferase; S-adenosylmethionine-dependent protein methyltransferase; capable of automethylation; member of the seven beta-strand family; YNL092W is not an essential gene; Belongs to the carnosine N-methyltransferase family.


ensembl_gene_id: YNL093W
symbol: YPT53
gene_biotype: protein_coding
description:
  GTP-binding protein YPT53; Stress-induced Rab family GTPase; required for vacuolar protein sorting and endocytosis; involved in ionic stress tolerance; similar to Vps21p and Ypt52p; functional homolog of Vps21p; mammalian Rab5 homolog; YPT53 has a paralog, VPS21, that arose from the whole genome duplication.


ensembl_gene_id: YNL094W
symbol: APP1
gene_biotype: protein_coding
description:
  Phosphatidate phosphatase, converts phosphatidate to diacylglycerol; App1p, Pah1p, Dpp1p, and Lpp1p are responsible for all the phosphatidate phosphatase activity; component of cortical actin patches; interacts with components of endocytic pathway.


ensembl_gene_id: YNL095C
symbol: YNL095C
gene_biotype: protein_coding
description:
  Uncharacterized transporter YNL095C; Putative protein of unknown function; predicted to contain a transmembrane domain; not an essential gene; YNL095C has a paralog, ECM3, that arose from the whole genome duplication.


ensembl_gene_id: YNL096C
symbol: RPS7B
gene_biotype: protein_coding
description:
  Protein component of the small (40S) ribosomal subunit; interacts with Kti11p; deletion causes hypersensitivity to zymocin; homologous to mammalian ribosomal protein S7, no bacterial homolog; RPS7B has a paralog, RPS7A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YNL097C
symbol: PHO23
gene_biotype: protein_coding
description:
  Transcriptional regulatory protein PHO23; Component of the Rpd3L histone deacetylase complex; involved in transcriptional regulation of PHO5; affects termination of snoRNAs and cryptic unstable transcripts (CUTs); C-terminus shares significant sequence identity with the human candidate tumor suppressor p33-ING1 and its isoform ING3.


ensembl_gene_id: YNL097W-A
symbol: YNL097W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YNL097W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified gene PHO23/YNL097C.


ensembl_gene_id: YNL098C
symbol: RAS2
gene_biotype: protein_coding
description:
  Ras-like protein 2; GTP-binding protein; regulates nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; homolog of mammalian Ras proto-oncogenes; RAS2 has a paralog, RAS1, that arose from the whole genome duplication; Belongs to the small GTPase superfamily. Ras family.


ensembl_gene_id: YNL099C
symbol: OCA1
gene_biotype: protein_coding
description:
  Putative protein tyrosine phosphatase; required for cell cycle arrest in response to oxidative damage of DNA.


ensembl_gene_id: YNL100W
symbol: MIC27
gene_biotype: protein_coding
description:
  Component of the MICOS complex; MICOS (formerly MINOS or MitOS) is a mitochondrial inner membrane complex that extends into the intermembrane space and has a role in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane; forms a subcomplex with Mic10p and Mic12p whose assembly and stability requires cardiolipin; Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.


ensembl_gene_id: YNL101W
symbol: AVT4
gene_biotype: protein_coding
description:
  Vacuolar transporter; exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters; localizes to sites of contact between the vacuole and mitochondria (vCLAMPs).


ensembl_gene_id: YNL102W
symbol: POL1
gene_biotype: protein_coding
description:
  Catalytic subunit of the DNA polymerase I alpha-primase complex; required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis.


ensembl_gene_id: YNL103W
symbol: MET4
gene_biotype: protein_coding
description:
  Leucine-zipper transcriptional activator; responsible for regulation of sulfur amino acid pathway; requires different combinations of auxiliary factors Cbf1p, Met28p, Met31p and Met32p; feedforward loop exists in the regulation of genes controlled by Met4p and Met32p; can be ubiquitinated by ubiquitin ligase SCF-Met30p, is either degraded or maintained in an inactive state; regulates degradation of its own DNA-binding cofactors by targeting them to SCF-Met30p; Belongs to the bZIP family.


ensembl_gene_id: YNL103W-A
symbol: YNL103W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YNL103W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MET4/YNL104C.


ensembl_gene_id: YNL104C
symbol: LEU4
gene_biotype: protein_coding
description:
  Alpha-isopropylmalate synthase (2-isopropylmalate synthase); the main isozyme responsible for the first step in the leucine biosynthesis pathway; LEU4 has a paralog, LEU9, that arose from the whole genome duplication; Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.


ensembl_gene_id: YNL105W
symbol: RRT16
gene_biotype: protein_coding
description:
  Putative regulator of rDNA transcription protein 16; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription.


ensembl_gene_id: YNL106C
symbol: INP52
gene_biotype: protein_coding
description:
  Phosphatidylinositol 4,5-bisphosphate 5-phosphatase; Polyphosphatidylinositol phosphatase; dephosphorylates a number of phosphatidylinositol phosphates (PtdInsPs, PIPs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain; INP52 has a paralog, INP53, that arose from the whole genome duplication.


ensembl_gene_id: YNL107W
symbol: YAF9
gene_biotype: protein_coding
description:
  Protein AF-9 homolog; Subunit of NuA4 histone H4 acetyltransferase and SWR1 complexes; may function to antagonize silencing near telomeres; interacts directly with Swc4p; has homology to human leukemogenic protein AF9; contains a YEATS domain.


ensembl_gene_id: YNL108C
symbol: YNL108C
gene_biotype: protein_coding
description:
  Uncharacterized protein YNL108C; Protein phosphatase; similar to prokaryotic phosphotransfer enzymes; null mutant shows alterations in glucose metabolism; GFP-fusion protein localizes to the cytoplasm and nucleus; YNL108C has a paralog, TFC7, that arose from the whole genome duplication.


ensembl_gene_id: YNL109W
symbol: YNL109W
gene_biotype: protein_coding
description:
  Putative uncharacterized membrane protein YNL109W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YNL108C.


ensembl_gene_id: YNL110C
symbol: NOP15
gene_biotype: protein_coding
description:
  Ribosome biogenesis protein 15; Constituent of 66S pre-ribosomal particles; involved in 60S ribosomal subunit biogenesis; localizes to both nucleolus and cytoplasm.


ensembl_gene_id: YNL111C
symbol: CYB5
gene_biotype: protein_coding
description:
  Cytochrome b5; involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation.


ensembl_gene_id: YNL112W
symbol: DBP2
gene_biotype: protein_coding
description:
  ATP-dependent RNA helicase of the DEAD-box protein family; has strong preference for dsRNA; interacts with YRA1; required for assembly of Yra1p, Nab2p and Mex67p onto mRNA and formation of nuclear mRNP; involved in mRNA decay and rRNA processing; may be involved in suppression of transcription from cryptic initiation sites.


ensembl_gene_id: YNL114C
symbol: YNL114C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YNL114C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPC19/YNL113W, an RNA polymerase subunit.


ensembl_gene_id: YNL115C
symbol: YNL115C
gene_biotype: protein_coding
description:
  Uncharacterized vacuolar membrane protein YNL115C; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL115C is not an essential gene.


ensembl_gene_id: YNL116W
symbol: DMA2
gene_biotype: protein_coding
description:
  Ubiquitin-protein ligase (E3); controls septin dynamics and spindle position checkpoint (SPOC) with ligase Dma1p by regulating recruitment of Elm1p to bud neck; regulates levels of eIF2 subunit Gcd11p, as well as abundance, localization, and ubiquitination of Cdk inhibitory kinase Swe1p; ortholog of human RNF8, similar to human Chfr; contains FHA and RING finger domains; DMA2 has a paralog, DMA1, that arose from the whole genome duplication.


ensembl_gene_id: YNL117W
symbol: MLS1
gene_biotype: protein_coding
description:
  Malate synthase, enzyme of the glyoxylate cycle; involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth on oleic acid, otherwise cytosolic; can accept butyryl-CoA as acyl-CoA donor in addition to traditional substrate acetyl-CoA.


ensembl_gene_id: YNL118C
symbol: DCP2
gene_biotype: protein_coding
description:
  m7GpppN-mRNA hydrolase; Catalytic subunit of Dcp1p-Dcp2p decapping enzyme complex; removes 5' cap structure from mRNAs prior to their degradation; also enters nucleus and positively regulates transcription initiation; nudix hydrolase family member; forms cytoplasmic foci upon DNA replication stress; human homolog DCP2 complements yeast dcp2 thermosensitive mutant.


ensembl_gene_id: YNL119W
symbol: NCS2
gene_biotype: protein_coding
description:
  Cytoplasmic tRNA 2-thiolation protein 2; Protein required for uridine thiolation of Lys(UUU) and Glu(UUC) tRNAs; required for the thiolation of uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae; Belongs to the CTU2/NCS2 family.


ensembl_gene_id: YNL120C
symbol: YNL120C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YNL120C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion enhances replication of Brome mosaic virus in S. cerevisiae, but likely due to effects on the overlapping gene.


ensembl_gene_id: YNL121C
symbol: TOM70
gene_biotype: protein_coding
description:
  Mitochondrial import receptor subunit TOM70; Component of the TOM (translocase of outer membrane) complex; involved in the recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins; TOM70 has a paralog, TOM71, that arose from the whole genome duplication.


ensembl_gene_id: YNL122C
symbol: YNL122C
gene_biotype: protein_coding
description:
  Mitochondrial ribosomal protein of the large subunit; homologous to bacterial L35 and human MRPL35 ribosomal proteins.


ensembl_gene_id: YNL123W
symbol: NMA111
gene_biotype: protein_coding
description:
  Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases; Belongs to the peptidase S1C family.


ensembl_gene_id: YNL124W
symbol: NAF1
gene_biotype: protein_coding
description:
  H/ACA ribonucleoprotein complex non-core subunit NAF1; RNA-binding protein required for the assembly of box H/ACA snoRNPs; thus required for pre-rRNA processing; forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; similar to Gar1p; Belongs to the NAF1 family.


ensembl_gene_id: YNL125C
symbol: ESBP6
gene_biotype: protein_coding
description:
  Uncharacterized transporter ESBP6; Protein with similarity to monocarboxylate permeases; appears not to be involved in transport of monocarboxylates such as lactate, pyruvate or acetate across the plasma membrane.


ensembl_gene_id: YNL126W
symbol: SPC98
gene_biotype: protein_coding
description:
  Spindle pole body component SPC98; Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque.


ensembl_gene_id: YNL127W
symbol: FAR11
gene_biotype: protein_coding
description:
  Factor arrest protein 11; Protein involved in recovery from cell cycle arrest; acts in response to pheromone; also involved in regulation of intra-S DNA damage checkpoint and autophagy; is essential for dephosphorylation of Atg13p; interacts with Far3p, Far7p, Far8p, Far9p, Far10p and with the phosphatases Pph21p, Pph22p and Pph3p; has similarity to the N- and C-termini of N. crassa HAM-2; similar to human Fam40A and Fam40B; Belongs to the FAR11 family.


ensembl_gene_id: YNL128W
symbol: TEP1
gene_biotype: protein_coding
description:
  Probable phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TEP1; PTEN homolog with no demonstrated inositol lipid phosphatase activity; plays a role in normal sporulation; homolog of human tumor suppressor gene PTEN/MMAC1/TEP1 and fission yeast ptn1.


ensembl_gene_id: YNL129W
symbol: NRK1
gene_biotype: protein_coding
description:
  Nicotinamide riboside kinase; catalyzes the phosphorylation of nicotinamide riboside and nicotinic acid riboside in salvage pathways for NAD+ biosynthesis.


ensembl_gene_id: YNL130C
symbol: CPT1
gene_biotype: protein_coding
description:
  Cholinephosphotransferase; required for phosphatidylcholine biosynthesis and for inositol-dependent regulation of EPT1 transcription; CPT1 has a paralog, EPT1, that arose from the whole genome duplication; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.


ensembl_gene_id: YNL130C-A
symbol: DGR1
gene_biotype: protein_coding
description:
  2-deoxy-glucose resistant protein 1, mitochondrial; Protein of unknown function; dgr1 null mutant is resistant to 2-deoxy-D-glucose.


ensembl_gene_id: YNL131W
symbol: TOM22
gene_biotype: protein_coding
description:
  Mitochondrial import receptor subunit TOM22; Component of the TOM (Translocase of Outer Membrane) complex; responsible for initial import of mitochondrially directed proteins; mediates interaction between TOM and TIM complexes and acts as a receptor for precursor proteins; Belongs to the Tom22 family.


ensembl_gene_id: YNL132W
symbol: KRE33
gene_biotype: protein_coding
description:
  RNA cytidine acetyltransferase; Protein required for biogenesis of the small ribosomal subunit; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance; essential gene; NAT10, the human homolog, implicated in several types of cancer and premature aging.


ensembl_gene_id: YNL133C
symbol: FYV6
gene_biotype: protein_coding
description:
  Protein of unknown function; required for survival upon exposure to K1 killer toxin; proposed to regulate double-strand break repair via non-homologous end-joining.


ensembl_gene_id: YNL134C
symbol: YNL134C
gene_biotype: protein_coding
description:
  Uncharacterized protein YNL134C; NADH-dependent aldehyde reductase, involved in detoxification of furfural; expression is up-regulated in the presence of furfural and 5-hydroxymethylfurfural, which are compounds generated during lignocellulosic biomass pre-treatment; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YNL135C
symbol: FPR1
gene_biotype: protein_coding
description:
  FK506-binding protein 1; Peptidyl-prolyl cis-trans isomerase (PPIase); binds to the drugs FK506 and rapamycin; also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function; N-terminally propionylated in vivo; mutation is functionally complemented by human FKBP1A.


ensembl_gene_id: YNL136W
symbol: EAF7
gene_biotype: protein_coding
description:
  Chromatin modification-related protein EAF7; Subunit of the NuA4 histone acetyltransferase complex; NuA4 acetylates the N-terminal tails of histones H4 and H2A; Belongs to the EAF7 family.


ensembl_gene_id: YNL137C
symbol: NAM9
gene_biotype: protein_coding
description:
  37S ribosomal protein NAM9, mitochondrial; Mitochondrial ribosomal component of the small subunit; Belongs to the universal ribosomal protein uS4 family.


ensembl_gene_id: YNL138W
symbol: SRV2
gene_biotype: protein_coding
description:
  CAP (cyclase-associated protein); N-terminus binds adenylate cyclase and facilitates activation by RAS; N-terminus forms novel hexameric star-shaped shuriken structures that directly catalyze cofilin-mediated severing of actin filaments; C-terminus binds and recycles cofilin bound, ADP-actin monomers, facilitating regulation of actin dynamics and cell morphogenesis; N- and C-termini can function as physically separate proteins; mCAP1 is the mouse homolog.


ensembl_gene_id: YNL138W-A
symbol: YSF3
gene_biotype: protein_coding
description:
  RDS3 complex subunit 10; Component of the SF3b subcomplex of the U2 snRNP; essential protein required for splicing and for assembly of SF3b.


ensembl_gene_id: YNL139C
symbol: THO2
gene_biotype: protein_coding
description:
  Subunit of the THO complex; THO is required for efficient transcription elongation and involved in transcriptional elongation-associated recombination; required for LacZ RNA expression from certain plasmids; Belongs to the THOC2 family.


ensembl_gene_id: YNL140C
symbol: YNL140C
gene_biotype: protein_coding
description:
  Uncharacterized protein YNL140C; Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps THO2/YNL139C.


ensembl_gene_id: YNL141W
symbol: AAH1
gene_biotype: protein_coding
description:
  Adenine deaminase (adenine aminohydrolase); converts adenine to hypoxanthine; involved in purine salvage; transcriptionally regulated by nutrient levels and growth phase; Aah1p degraded upon entry into quiescence via SCF and the proteasome.


ensembl_gene_id: YNL142W
symbol: MEP2
gene_biotype: protein_coding
description:
  Ammonium transporter MEP2; Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation; Belongs to the ammonia transporter channel (TC 1.A.11.2) family.


ensembl_gene_id: YNL143C
symbol: YNL143C
gene_biotype: protein_coding
description:
  Uncharacterized membrane protein YNL143C; Protein of unknown function; expressed at both mRNA and protein levels.


ensembl_gene_id: YNL144C
symbol: YNL144C
gene_biotype: protein_coding
description:
  Uncharacterized protein YNL144C; Putative protein of unknown function; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; contains a PH domain and binds phosphatidylinositols and phosphatidylethanolamine in a large-scale study; YNL144C has a paralog, YHR131C, that arose from the whole genome duplication; To yeast YHR131c.


ensembl_gene_id: YNL144W-A
symbol: YNL144W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YNL144W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YNL144C.


ensembl_gene_id: YNL145W
symbol: MFA2
gene_biotype: protein_coding
description:
  Mating pheromone a-factor; made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA1.


ensembl_gene_id: YNL146W
symbol: YNL146W
gene_biotype: protein_coding
description:
  Uncharacterized protein YNL146W; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNL146W is not an essential gene.


ensembl_gene_id: YNL147W
symbol: LSM7
gene_biotype: protein_coding
description:
  U6 snRNA-associated Sm-like protein LSm7; Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress.


ensembl_gene_id: YNL148C
symbol: ALF1
gene_biotype: protein_coding
description:
  Tubulin-specific chaperone B; Alpha-tubulin folding protein; similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenance; Belongs to the TBCB family.


ensembl_gene_id: YNL149C
symbol: PGA2
gene_biotype: protein_coding
description:
  Essential protein required for maturation of Gas1p and Pho8p; involved in protein trafficking; GFP-fusion protein localizes to the ER and YFP-fusion protein to the nuclear envelope-ER network; null mutants have a cell separation defect; Belongs to the PGA2 family.


ensembl_gene_id: YNL150W
symbol: YNL150W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YNL150W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; extensive overlap with PGA2/YNL149C, an uncharacterized gene with a proposed role in protein trafficking.


ensembl_gene_id: YNL152W
symbol: INN1
gene_biotype: protein_coding
description:
  Ingression protein 1; Essential protein that associates with contractile actomyosin ring; required for ingression of the plasma membrane into the bud neck during cytokinesis; C2 domain, a membrane targeting module, is required for function; activates chitin synthase activity of Chs2p during cytokinesis.


ensembl_gene_id: YNL153C
symbol: GIM3
gene_biotype: protein_coding
description:
  Prefoldin subunit 4; Subunit of the heterohexameric cochaperone prefoldin complex; prefoldin binds specifically to cytosolic chaperonin and transfers target proteins to it; prefoldin complex also localizes to chromatin of actively transcribed genes in the nucleus and facilitates transcriptional elongation.


ensembl_gene_id: YNL154C
symbol: YCK2
gene_biotype: protein_coding
description:
  Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform; shares redundant functions with Yck1p in morphogenesis, proper septin assembly, endocytic trafficking, and glucose sensing; stabilized by Sod1p binding in the presence of glucose and oxygen, causing glucose repression of respiratory metabolism; involved in the phosphorylation and regulation of glucose sensor Rgt2p; YCK2 has a paralog, YCK1, that arose from the whole genome duplication.


ensembl_gene_id: YNL155W
symbol: CUZ1
gene_biotype: protein_coding
description:
  CDC48-associated ubiquitin-like/zinc finger protein 1; Protein with a role in the ubiquitin-proteasome pathway; interacts with ubiquitinated protein, Cdc48p and the proteasomal regulatory particle; may protect cells from trivalent metalloid induced proteotoxicity; contains a PACE promoter element and is co-regulated with proteasome subunit genes; AN1-type zinc finger protein, with DHHC and ubiquitin-like domains (UBL); ortholog of ZFAND1, a human gene linked to cancer; protein abundance increases under DNA replication stress.


ensembl_gene_id: YNL156C
symbol: NSG2
gene_biotype: protein_coding
description:
  Protein involved in regulation of sterol biosynthesis; specifically stabilizes Hmg2p, one of two HMG-CoA isoenzymes that catalyze the rate-limiting step in sterol biosynthesis; homolog of mammalian INSIG proteins; NSG2 has a paralog, NSG1, that arose from the whole genome duplication.


ensembl_gene_id: YNL157W
symbol: IGO1
gene_biotype: protein_coding
description:
  mRNA stability protein IGO1; Protein required for initiation of G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylated by Rim15p; GFP protein localizes to the cytoplasm and nucleus; IGO1 has a paralog, IGO2, that arose from the whole genome duplication.


ensembl_gene_id: YNL158W
symbol: PGA1
gene_biotype: protein_coding
description:
  GPI mannosyltransferase 2 subunit PGA1; Essential component of GPI-mannosyltransferase II; complex is responsible for second mannose addition to GPI precursors as a partner of Gpi18p; required for maturation of Gas1p and Pho8p; has synthetic genetic interactions with secretory pathway genes.


ensembl_gene_id: YNL159C
symbol: ASI2
gene_biotype: protein_coding
description:
  Protein ASI2; Subunit of the inner nuclear membrane Asi ubiquitin ligase complex; the Asi complex targets both misfolded proteins of the inner nuclear membrane-associated degradation (INMAD) pathway and inner for ubiquitin-mediated degradation; acts with Asi1p and Asi3p to ensure the fidelity of SPS-sensor signaling by targeting latent unprocessed forms of Stp1p and Stp2p, maintaining the repressed state of gene expression in the absence of inducing amino acids.


ensembl_gene_id: YNL160W
symbol: YGP1
gene_biotype: protein_coding
description:
  Protein YGP1; Cell wall-related secretory glycoprotein; induced by nutrient deprivation-associated growth arrest and upon entry into stationary phase; may be involved in adaptation prior to stationary phase entry; YGP1 has a paralog, SPS100, that arose from the whole genome duplication; To yeast sporulation-specific protein SPS100.


ensembl_gene_id: YNL161W
symbol: CBK1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase CBK1; Serine/threonine protein kinase of the the RAM signaling network; Ndr/LATS family member; binds regulatory subunit Mob2p; involved in regulation of cellular morphogenesis, polarized growth, and septum destruction; phosphorylation by Cbk1p regulates localization and activity of Ace2p transcription factor and Ssd1p translational repressor; Cbk1p activity is regulated by both phosphorylation and specific localization; relocalizes to cytoplasm upon DNA replication stress; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. COT [...]


ensembl_gene_id: YNL162W
symbol: RPL42A
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L42A; homologous to mammalian ribosomal protein L36A, no bacterial homolog; RPL42A has a paralog, RPL42B, that arose from the whole genome duplication.


ensembl_gene_id: YNL163C
symbol: RIA1
gene_biotype: protein_coding
description:
  Ribosome assembly protein 1; Cytoplasmic GTPase/eEF2-like factor involved in ribosomal biogenesis; with Sdo1p, a guanine nucleotide exchange factor (GEF), promotes release of Tif6p from 60S ribosomal subunits in the cytoplasm so that they can assemble with 40S subunits to generate mature ribosomes; required for quality control check of newly made large ribosomal subunits before they are released into the pool of translating ribosomes; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family.


ensembl_gene_id: YNL164C
symbol: IBD2
gene_biotype: protein_coding
description:
  Protein IBD2; Component of the BUB2-dependent spindle checkpoint pathway; interacts with Bfa1p and functions upstream of Bub2p and Bfa1p.


ensembl_gene_id: YNL166C
symbol: BNI5
gene_biotype: protein_coding
description:
  Bud neck protein 5; Linker protein responsible for recruitment of myosin to the bud neck; interacts with the C-terminal extensions of septins Cdc11p and Shs1p and binds Myo1p to promote cytokinesis.


ensembl_gene_id: YNL167C
symbol: SKO1
gene_biotype: protein_coding
description:
  CRE-binding bZIP protein SKO1; Basic leucine zipper transcription factor of the ATF/CREB family; forms a complex with Tup1p and Cyc8p to both activate and repress transcription; cytosolic and nuclear protein involved in osmotic and oxidative stress responses.


ensembl_gene_id: YNL168C
symbol: FMP41
gene_biotype: protein_coding
description:
  Uncharacterized mitochondrial hydrolase FMP41; Putative protein of unknown function; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies.


ensembl_gene_id: YNL169C
symbol: PSD1
gene_biotype: protein_coding
description:
  Phosphatidylserine decarboxylase of the mitochondrial inner membrane; converts phosphatidylserine to phosphatidylethanolamine; regulates mitochondrial fusion and morphology by affecting lipid mixing in the mitochondrial membrane and by influencing the ratio of long to short forms of Mgm1p; partly exposed to the mitochondrial intermembrane space; autocatalytically processed; Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.


ensembl_gene_id: YNL170W
symbol: YNL170W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YNL170W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YNL171C
symbol: YNL171C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YNL171C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YNL172W
symbol: APC1
gene_biotype: protein_coding
description:
  Largest subunit of the Anaphase-Promoting Complex/Cyclosome; APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; localizes to nuclear foci that become diffuse upon DNA replication stress; Belongs to the APC1 family.


ensembl_gene_id: YNL173C
symbol: MDG1
gene_biotype: protein_coding
description:
  Signal transduction protein MDG1; Plasma membrane protein; involved in G-protein mediated pheromone signaling pathway; overproduction suppresses bem1 mutations; MDG1 has a paralog, CRP1, that arose from the whole genome duplication.


ensembl_gene_id: YNL174W
symbol: YNL174W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YNL174W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene NOP13/YNL175C.


ensembl_gene_id: YNL175C
symbol: NOP13
gene_biotype: protein_coding
description:
  Nucleolar protein found in preribosomal complexes; contains an RNA recognition motif (RRM); relative distribution to the nucleolus increases upon DNA replication stress.


ensembl_gene_id: YNL176C
symbol: TDA7
gene_biotype: protein_coding
description:
  Topoisomerase I damage affected protein 7; Cell cycle-regulated gene of unknown function; promoter bound by Fkh2p; null mutant is sensitive to expression of the top1-T722A allele; TDA7 has a paralog, YDL211C, that arose from the whole genome duplication.


ensembl_gene_id: YNL178W
symbol: RPS3
gene_biotype: protein_coding
description:
  Protein component of the small (40S) ribosomal subunit; has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; nascent Rps3p is bound by specific chaperone Yar1p during translation; homologous to mammalian ribosomal protein S3 and bacterial S3.


ensembl_gene_id: YNL179C
symbol: YNL179C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YNL179C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance.


ensembl_gene_id: YNL180C
symbol: RHO5
gene_biotype: protein_coding
description:
  GTP-binding protein RHO5; Non-essential small GTPase of the Rho/Rac family of Ras-like proteins; RAC1 ortholog; regulated by phosphorylation and ubiquitination; likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity.


ensembl_gene_id: YNL181W
symbol: PBR1
gene_biotype: protein_coding
description:
  Uncharacterized oxidoreductase YNL181W; Putative oxidoreductase; required for cell viability; Belongs to the short-chain dehydrogenases/reductases (SDR) family.


ensembl_gene_id: YNL182C
symbol: IPI3
gene_biotype: protein_coding
description:
  Pre-rRNA-processing protein IPI3; Component of the Rix1 complex and pre-replicative complexes (pre-RCs); required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-RC formation and maintenance during DNA replication licensing; highly conserved protein which contains several WD40 motifs; IPI3 is an essential gene; other members include Rix1p, Ipi1p, and Ipi3p.


ensembl_gene_id: YNL183C
symbol: NPR1
gene_biotype: protein_coding
description:
  Nitrogen permease reactivator protein; Protein kinase; stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis through phosphorylation of Ldb19p, which prevents its association with the plasma membrane; Npr1p activity is negatively regulated via phosphorylation by the TOR complex; NPR1 has a paralog, PRR2, that arose from the whole genome duplication.


ensembl_gene_id: YNL184C
symbol: YNL184C
gene_biotype: protein_coding
description:
  Uncharacterized protein YNL184C; Protein of unknown function; expressed at both mRNA and protein levels.


ensembl_gene_id: YNL186W
symbol: UBP10
gene_biotype: protein_coding
description:
  Ubiquitin carboxyl-terminal hydrolase 10; Ubiquitin-specific protease, deubiquitinates Ub-protein moieties; interacts with proteins that function in rRNA production and ribosome biogenesis via its intrinsically disordered regions; stabilizes Rpa190p by deubiquitination; controls PCNA deubiquitylation; may regulate silencing by acting on Sir4p; involved in posttranscriptionally regulating Gap1p, possibly other transporters; localized to the nucleolus; null mutant phenotypes are functionally complemented by human USP36; Belongs to the peptidase C19 family.


ensembl_gene_id: YNL187W
symbol: SWT21
gene_biotype: protein_coding
description:
  Protein involved in mRNA splicing; contains a consensus nuclear export signal (NES) sequence similar to the consensus sequence recognized by Crm1p; interacts genetically with Prp40p and Tgs1p; contains WD40 repeats.


ensembl_gene_id: YNL188W
symbol: KAR1
gene_biotype: protein_coding
description:
  Cell division control protein KAR1; Protein involved in karyogamy and spindle pole body duplication; involved in karyogamy during mating; involved in spindle pole body duplication during mitosis; localizes to the half-bridge of the spindle pole body; interacts with Spc72p during karyogamy; also interacts with Cdc31p; essential gene.


ensembl_gene_id: YNL189W
symbol: SRP1
gene_biotype: protein_coding
description:
  Importin subunit alpha; Karyopherin alpha homolog; forms a dimer with karyopherin beta Kap95p to mediate import of nuclear proteins, binds the nuclear localization signal of the substrate during import; involved in cotranslational protein degradation; binds ribosome-bound nascent polypeptides; Srp1p and Sts1p couple proteasomes to nascent polypeptides emerging from the ribosome for cotranslational degradation.


ensembl_gene_id: YNL190W
symbol: YNL190W
gene_biotype: protein_coding
description:
  Hydrophilin essential in desiccation-rehydration process; cell wall protein; contains a putative GPI-attachment site; Belongs to the PGA14 family.


ensembl_gene_id: YNL191W
symbol: DUG3
gene_biotype: protein_coding
description:
  Component of glutamine amidotransferase (GATase II); forms a complex with Dug2p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p).


ensembl_gene_id: YNL192W
symbol: CHS1
gene_biotype: protein_coding
description:
  Chitin synthase I; requires activation from zymogenic form in order to catalyze the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for repairing the chitin septum during cytokinesis; transcription activated by mating factor.


ensembl_gene_id: YNL193W
symbol: YNL193W
gene_biotype: protein_coding
description:
  Uncharacterized protein YNL193W; Putative protein of unknown function; exhibits a two-hybrid interaction with Yhr151cp in a large-scale analysis.


ensembl_gene_id: YNL194C
symbol: YNL194C
gene_biotype: protein_coding
description:
  Integral membrane protein; required for sporulation and plasma membrane sphingolipid content; similar to SUR7; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; GFP-fusion protein is more abundant at MCCs (membrane compartment occupied by Can1) in the presence of glycerol and oleate; YNL194C has a paralog, FMP45, that arose from the whole genome duplication.


ensembl_gene_id: YNL195C
symbol: YNL195C
gene_biotype: protein_coding
description:
  Uncharacterized protein YNL195C; Protein of unknown function; shares a promoter with YNL194C; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YNL195C has a paralog, HBT1, that arose from the whole genome duplication.


ensembl_gene_id: YNL196C
symbol: SLZ1
gene_biotype: protein_coding
description:
  Sporulation-specific protein with a leucine zipper motif; subunit of the MIS complex which controls mRNA methylation during during the induction of sporulation.


ensembl_gene_id: YNL197C
symbol: WHI3
gene_biotype: protein_coding
description:
  RNA binding protein that sequesters CLN3 mRNA in cytoplasmic foci; regulates genes involved in the cell cycle, sister chromatid cohesion, and stress response; acts as a cytoplasmic retention factor for Cdc28p and associated cyclins; regulates cell fate and dose-dependently regulates the critical cell size required for passage through Start; Tpk1p (PKA) mediated phosphorylation (S568) inhibits Whi3p function, decreasing its interaction with CLN3 mRNA; regulates ploidy.


ensembl_gene_id: YNL198C
symbol: YNL198C
gene_biotype: protein_coding
description:
  Uncharacterized protein YNL198C, mitochondrial; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YNL199C
symbol: GCR2
gene_biotype: protein_coding
description:
  Transcriptional activator of genes involved in glycolysis; interacts and functions with the DNA-binding protein Gcr1p.


ensembl_gene_id: YNL200C
symbol: NNR1
gene_biotype: protein_coding
description:
  NADHX epimerase; catalyzes isomerization of (R)- and (S)-NADHX; homologous to AIBP in mammals and the N- terminal domain of YjeF in E.coli; enzyme is widespread in eukaryotes, prokaryotes and archaea; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Belongs to the NnrE/AIBP family.


ensembl_gene_id: YNL201C
symbol: PSY2
gene_biotype: protein_coding
description:
  Subunit of protein phosphatase PP4 complex; Pph3p and Psy2p form the active complex, Psy4p may provide additional substrate specificity; regulates recovery from the DNA damage checkpoint, the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair and efficient Non-Homologous End-Joining (NHEJ) pathway; Pph3p and Psy2p localize to foci on meiotic chromosomes; putative homolog of mammalian R3.


ensembl_gene_id: YNL202W
symbol: SPS19
gene_biotype: protein_coding
description:
  Peroxisomal 2,4-dienoyl-CoA reductase; auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate; Belongs to the short-chain dehydrogenases/reductases (SDR) family.


ensembl_gene_id: YNL203C
symbol: YNL203C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YNL203C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YNL204C
symbol: SPS18
gene_biotype: protein_coding
description:
  Sporulation protein SPS18; Protein of unknown function, contains a putative zinc-binding domain; expressed during sporulation; SPS18 has a paralog, GCS1, that arose from the whole genome duplication.


ensembl_gene_id: YNL205C
symbol: YNL205C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YNL205C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YNL206C
symbol: RTT106
gene_biotype: protein_coding
description:
  Histone chaperone; involved in regulation of chromatin structure in both transcribed and silenced chromosomal regions; affects transcriptional elongation; has a role in regulation of Ty1 transposition; interacts physically and functionally with Chromatin Assembly Factor-1 (CAF-1); Belongs to the RTT106 family.


ensembl_gene_id: YNL207W
symbol: RIO2
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase RIO2; Essential serine kinase involved in the processing of 20S pre-rRNA; involved in the processing of the 20S pre-rRNA into mature 18S rRNA; has similarity to Rio1p.


ensembl_gene_id: YNL208W
symbol: YNL208W
gene_biotype: protein_coding
description:
  Uncharacterized protein YNL208W; Protein of unknown function; may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; potential orthologs found in other fungi.


ensembl_gene_id: YNL209W
symbol: SSB2
gene_biotype: protein_coding
description:
  Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in the folding of newly-synthesized polypeptide chains; member of the HSP70 family; SSB2 has a paralog, SSB1, that arose from the whole genome duplication; Belongs to the heat shock protein 70 family. Ssb-type Hsp70 subfamily.


ensembl_gene_id: YNL210W
symbol: MER1
gene_biotype: protein_coding
description:
  Meiotic recombination 1 protein; mRNA-binding protein required for meiosis-specific mRNA splicing; required for chromosome pairing and meiotic recombination; Mer1p regulon embraces four essential meiotic pre-mRNAs: REC107, HFM1, AMA1 and SPO22.


ensembl_gene_id: YNL211C
symbol: MRX7
gene_biotype: protein_coding
description:
  MIOREX complex component 7; Protein that associates with mitochondrial ribosome; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL211C is not an essential gene.


ensembl_gene_id: YNL212W
symbol: VID27
gene_biotype: protein_coding
description:
  Vacuolar import and degradation protein 27; Cytoplasmic protein of unknown function; possibly involved in vacuolar protein degradation; not essential for proteasome-dependent degradation of fructose-1,6-bisphosphatase (FBPase); null mutants exhibit normal growth; contains two PH-like domains.


ensembl_gene_id: YNL213C
symbol: RRG9
gene_biotype: protein_coding
description:
  Required for respiratory growth protein 9, mitochondrial; Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies.


ensembl_gene_id: YNL214W
symbol: PEX17
gene_biotype: protein_coding
description:
  Membrane peroxin of the peroxisomal importomer complex; complex facilitates the import of peroxisomal matrix proteins; required for peroxisome biogenesis.


ensembl_gene_id: YNL215W
symbol: IES2
gene_biotype: protein_coding
description:
  Ino eighty subunit 2; Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress; Belongs to the IES2 family.


ensembl_gene_id: YNL216W
symbol: RAP1
gene_biotype: protein_coding
description:
  DNA-binding protein RAP1; Essential DNA-binding transcription regulator that binds many loci; involved in transcription activation, repression, chromatin silencing, telomere length maintenance; relocalizes to cytosol under hypoxia; conserved protein with N-terminal BRCT domain, central region with homology to Myb DNA binding domain, and C-terminal Rap1-specific protein-interaction domain (RCT domain); recruits Sir complex to telomeric DNA; present in quiescent cell telomere hyperclusters.


ensembl_gene_id: YNL217W
symbol: YNL217W
gene_biotype: protein_coding
description:
  Putative metallophosphoesterase YNL217W; Putative protein of unknown function; weak sequence similarity to bis (5'-nucleotidyl)-tetraphosphatases; (GFP)-fusion protein localizes to the vacuole; null mutant is highly sensitive to azaserine and resistant to sodium-O-vandate.


ensembl_gene_id: YNL218W
symbol: MGS1
gene_biotype: protein_coding
description:
  Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress; Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.


ensembl_gene_id: YNL219C
symbol: ALG9
gene_biotype: protein_coding
description:
  Alpha-1,2-mannosyltransferase ALG9; Mannosyltransferase, involved in N-linked glycosylation; catalyzes the transfer of both the seventh mannose residue on B-arm and ninth mannose residue on the C-arm from Dol-P-Man to lipid-linked oligosaccharides; human homolog ALG9 can complement yeast null mutant; mutation of human homolog causes type 1 congenital disorders of glycosylation.


ensembl_gene_id: YNL220W
symbol: ADE12
gene_biotype: protein_coding
description:
  Adenylosuccinate synthase; catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence.


ensembl_gene_id: YNL221C
symbol: POP1
gene_biotype: protein_coding
description:
  Ribonucleases P/MRP protein subunit POP1; Subunit of RNase MRP, nuclear RNase P and telomerase complexes; RNase MRP cleaves pre-rRNA, nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs, while telomerase replenishes telomeric DNA; binds to the RPR1 RNA subunit in RNase P.


ensembl_gene_id: YNL222W
symbol: SSU72
gene_biotype: protein_coding
description:
  RNA polymerase II subunit A C-terminal domain phosphatase SSU72; Phosphatase and transcription/RNA-processing factor; associates with TFIIB and cleavage/polyadenylation factor Pta1p; exhibits phosphatase activity on serine-5 and serine-7 of the RNA polymerase II C-terminal domain; affects start site selection and transcriptional read through in vivo.


ensembl_gene_id: YNL223W
symbol: ATG4
gene_biotype: protein_coding
description:
  Conserved cysteine protease required for autophagy; cleaves Atg8p to a form required for autophagosome and Cvt vesicle generation.


ensembl_gene_id: YNL224C
symbol: SQS1
gene_biotype: protein_coding
description:
  Protein that stimulates the ATPase and helicase activities of Prp43p; acts with Prp43p to stimulate 18s rRNA maturation by Nob1p; overexpression antagonizes the suppression of splicing defects by spp382 mutants; component of pre-ribosomal particles; relocalizes from nucleus to nucleolus upon DNA replication stress; Belongs to the SQS1 family.


ensembl_gene_id: YNL225C
symbol: CNM67
gene_biotype: protein_coding
description:
  Chaotic nuclear migration protein 67; Component of the spindle pole body outer plaque; required for spindle orientation and mitotic nuclear migration; CNM67 has a paralog, ADY3, that arose from the whole genome duplication.


ensembl_gene_id: YNL226W
symbol: YNL226W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YNL226W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene JJJ1/YNL227C.


ensembl_gene_id: YNL227C
symbol: JJJ1
gene_biotype: protein_coding
description:
  J protein JJJ1; Co-chaperone that stimulates the ATPase activity of Ssa1p; required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-domain; mutation causes defects in fluid-phase endocytosis.


ensembl_gene_id: YNL228W
symbol: YNL228W
gene_biotype: protein_coding
description:
  Putative uncharacterized membrane protein YNL228W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF YNL227C/JJJ1.


ensembl_gene_id: YNL229C
symbol: URE2
gene_biotype: protein_coding
description:
  Nitrogen catabolite repression transcriptional regulator; inhibits GLN3 transcription in good nitrogen source; role in sequestering Gln3p and Gat1p to the cytoplasm; has glutathione peroxidase activity and can mutate to acquire GST activity; self-assembly under limited nitrogen conditions creates [URE3] prion and releases catabolite repression.


ensembl_gene_id: YNL230C
symbol: ELA1
gene_biotype: protein_coding
description:
  Elongin-A; Elongin A; F-box protein that forms a heterodimer with Elc1p and is required for ubiquitin-dependent degradation of the RNA Polymerase II subunit Rpo21p; subunit of the Elongin-Cullin-Socs (ECS) ligase complex; Belongs to the ELA1 family.


ensembl_gene_id: YNL231C
symbol: PDR16
gene_biotype: protein_coding
description:
  Phosphatidylinositol transfer protein (PITP); controlled by the multiple drug resistance regulator Pdr1p; localizes to lipid particles and microsomes; controls levels of various lipids, may regulate lipid synthesis; homologous to Pdr17p; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YNL232W
symbol: CSL4
gene_biotype: protein_coding
description:
  Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain an S1 RNA binding domain; human homolog EXOSC1 partially complements yeast csl4 null mutant, and can complement inviability of strain in which expression of CSL4 is repressed.


ensembl_gene_id: YNL233W
symbol: BNI4
gene_biotype: protein_coding
description:
  Protein BNI4; Targeting subunit for Glc7p protein phosphatase; localized to the bud neck, required for localization of chitin synthase III to the bud neck via interaction with the chitin synthase III regulatory subunit Skt5p; phosphorylation by Slt2p and Kss1p involved in regulating Bni4p in septum assembly.


ensembl_gene_id: YNL234W
symbol: YNL234W
gene_biotype: protein_coding
description:
  Uncharacterized globin-like protein YNL234W; Protein of unknown function with similarity to globins; has a functional heme-binding domain; mutant has aneuploidy tolerance; transcription induced by stress conditions; may be involved in glucose signaling or metabolism; regulated by Rgt1.


ensembl_gene_id: YNL235C
symbol: YNL235C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YNL235C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SIN4/YNL236W, a subunit of the mediator complex.


ensembl_gene_id: YNL236W
symbol: SIN4
gene_biotype: protein_coding
description:
  Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; contributes to both postive and negative transcriptional regulation; dispensible for basal transcription.


ensembl_gene_id: YNL237W
symbol: YTP1
gene_biotype: protein_coding
description:
  Protein YTP1; Probable type-III integral membrane protein of unknown function; has regions of similarity to mitochondrial electron transport proteins.


ensembl_gene_id: YNL238W
symbol: KEX2
gene_biotype: protein_coding
description:
  Kexin, a subtilisin-like protease (proprotein convertase); a calcium-dependent serine protease involved in the activation of proproteins of the secretory pathway; Belongs to the peptidase S8 family. Furin subfamily.


ensembl_gene_id: YNL239W
symbol: LAP3
gene_biotype: protein_coding
description:
  Cysteine proteinase 1, mitochondrial; Cysteine aminopeptidase with homocysteine-thiolactonase activity; protects cells against homocysteine toxicity; has bleomycin hydrolase activity in vitro; transcription is regulated by galactose via Gal4p; orthologous to human BLMH; Belongs to the peptidase C1 family.


ensembl_gene_id: YNL240C
symbol: NAR1
gene_biotype: protein_coding
description:
  Cytosolic Fe-S cluster assembly factor NAR1; Subunit of the cytosolic iron-sulfur (FeS) protein assembly machinery; required for maturation of cytosolic and nuclear FeS proteins and for normal resistance to oxidative stress; deficiency results in shortened lifespan and sensitivity to paraquat; homologous to human Narf.


ensembl_gene_id: YNL241C
symbol: ZWF1
gene_biotype: protein_coding
description:
  Glucose-6-phosphate dehydrogenase (G6PD); catalyzes the first step of the pentose phosphate pathway; involved in adapting to oxidative stress; protein abundance increases in response to DNA replication stress; homolog of human G6PD which is deficient in patients with hemolytic anemia; human G6PD can complement yeast zwf1 null mutant.


ensembl_gene_id: YNL242W
symbol: ATG2
gene_biotype: protein_coding
description:
  Autophagy-related protein 2; Peripheral membrane protein required for autophagic vesicle formation; also required for vesicle formation during pexophagy and the cytoplasm-to-vaucole targeting (Cvt) pathway; involved in Atg9p cycling between the phagophore assembly site and mitochondria; contains an APT1 domain that binds phosphatidylinositol-3-phosphate; essential for cell cycle progression from G2/M to G1 under nitrogen starvation; forms cytoplasmic foci upon DNA replication stress.


ensembl_gene_id: YNL243W
symbol: SLA2
gene_biotype: protein_coding
description:
  Adaptor protein that links actin to clathrin and endocytosis; involved in membrane cytoskeleton assembly and cell polarization; present in the actin cortical patch of the emerging bud tip; dimer in vivo; Belongs to the SLA2 family.


ensembl_gene_id: YNL244C
symbol: SUI1
gene_biotype: protein_coding
description:
  Translation initiation factor eIF1; component of a complex involved in recognition of the initiator codon; modulates translation accuracy at the initiation phase; Belongs to the SUI1 family.


ensembl_gene_id: YNL245C
symbol: CWC25
gene_biotype: protein_coding
description:
  Pre-mRNA-splicing factor CWC25; Splicing factor required for the first step of pre-mRNA splicing; binding to the spliceosome requires Prp2p and Yju2p; heat-stable protein; has similarity to S. pombe Cwf25p; Belongs to the CWC25 family.


ensembl_gene_id: YNL246W
symbol: VPS75
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 75; NAP family histone chaperone; binds to histones and Rtt109p, stimulating histone acetyltransferase activity; possesses nucleosome assembly activity in vitro; proposed role in vacuolar protein sorting and in double-strand break repair; protein abundance increases in response to DNA replication stress; relocalizes to the cytosol in response to hypoxia.


ensembl_gene_id: YNL247W
symbol: YNL247W
gene_biotype: protein_coding
description:
  Cysteine--tRNA ligase; Cysteinyl-tRNA synthetase; may interact with ribosomes, based on co-purification experiments; human gene CARS allows growth of the yeast haploid null mutant after sporulation of a heterozygous diploid.


ensembl_gene_id: YNL248C
symbol: RPA49
gene_biotype: protein_coding
description:
  RNA polymerase I subunit A49; essential for nucleolar assembly and for high polymerase loading rate; required for nucleolar localization of Rpa34p.


ensembl_gene_id: YNL250W
symbol: RAD50
gene_biotype: protein_coding
description:
  DNA repair protein RAD50; Subunit of MRX complex with Mre11p and Xrs2p; complex is involved in processing double-strand DNA breaks in vegetative cells, initiation of meiotic DSBs, telomere maintenance, and nonhomologous end joining; forms nuclear foci upon DNA replication stress; Belongs to the SMC family. RAD50 subfamily.


ensembl_gene_id: YNL251C
symbol: NRD1
gene_biotype: protein_coding
description:
  Protein NRD1; RNA-binding subunit of Nrd1 complex; complex interacts with exosome to mediate 3'-end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; interacts with CTD of RNA pol II large subunit Rpo21p at phosphorylated Ser5 to direct transcription termination of non-polyadenylated transcripts; H3K4 trimethylation of transcribed regions by Set1p enhances recruitment of Nrd1p to those sites; role in regulation of mitochondrial abundance and cell size.


ensembl_gene_id: YNL254C
symbol: RTC4
gene_biotype: protein_coding
description:
  Restriction of telomere capping protein 4; Protein of unknown function; null mutation suppresses cdc13-1 temperature sensitivity; (GFP)-fusion protein localizes to both the cytoplasm and the nucleus.


ensembl_gene_id: YNL255C
symbol: GIS2
gene_biotype: protein_coding
description:
  Zinc finger protein GIS2; Translational activator for mRNAs with internal ribosome entry sites; associates with polysomes and binds to a specific subset of mRNAs; localizes to RNA processing bodies (P bodies) and to stress granules; may have a role in translation regulation under stress conditions; ortholog of human ZNF9/CNBP, a gene involved in myotonic dystrophy type 2.


ensembl_gene_id: YNL256W
symbol: FOL1
gene_biotype: protein_coding
description:
  6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; Multifunctional enzyme of the folic acid biosynthesis pathway; has dihydropteroate synthetase, dihydro-6-hydroxymethylpterin pyrophosphokinase, and dihydroneopterin aldolase activities; In the central section; belongs to the HPPK family.


ensembl_gene_id: YNL257C
symbol: SIP3
gene_biotype: protein_coding
description:
  Membrane-anchored lipid-binding protein SIP3; Putative sterol transfer protein; has a probable role in retrograde transport of sterols from the plasma membrane to the ER; co-localizes to puncta in the cortical ER with Ysp2p; contains GRAM, StART-like (VASt) and two PH-like domains; one of 6 StART-like domain-containing proteins in yeast that may be involved in sterol transfer between intracellular membranes; conserved across eukaryotes; previously identified as a transcription cofactor that interacts with DNA-bound Snf1p.


ensembl_gene_id: YNL258C
symbol: DSL1
gene_biotype: protein_coding
description:
  Peripheral membrane protein needed for Golgi-to-ER retrograde traffic; mediates Sey1p-independent homotypic ER fusion; forms Dsl1 tethering complex with Sec39p and Tip20p that forms a stable complex with ER SNAREs Sec20p, Ufe1p and Use1p and is functionally conserved from yeast to mammalian cells; component of the ER target site that interacts with coatomer; interacts with different subunits of COPI vesicle coat; interacts with Cin5p; homolog of fly and human ZW10 gene.


ensembl_gene_id: YNL259C
symbol: ATX1
gene_biotype: protein_coding
description:
  Metal homeostasis factor ATX1; Cytosolic copper metallochaperone; transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake; human homolog ATOX1 can complement yeast atx1 mutant; overexpression of human ATOX1 suppresses lysine auxotrophy of the yeast sod1 null mutant, as does overexpression of yeast ATX1.


ensembl_gene_id: YNL260C
symbol: LTO1
gene_biotype: protein_coding
description:
  Essential protein that forms a complex with Rli1p and Yae1p; ortholog of human ORAOV1, which is overexpressed in solid tumors; inviability of null mutant under standard conditions is complemented by overexpression of ORAOV1; essential for growth under standard (aerobic) conditions but not under anaerobic conditions; may have a role in protection of ribosomal assembly and function from damage due to reactive oxygen species.


ensembl_gene_id: YNL261W
symbol: ORC5
gene_biotype: protein_coding
description:
  Subunit of the origin recognition complex (ORC); ORC directs DNA replication by binding to replication origins and is also involved in transcriptional silencing.


ensembl_gene_id: YNL262W
symbol: POL2
gene_biotype: protein_coding
description:
  Catalytic subunit of DNA polymerase (II) epsilon; a chromosomal DNA replication polymerase that exhibits processivity and proofreading exonuclease activity; participates in leading-strand synthesis during DNA replication; also involved in DNA synthesis during DNA repair; interacts extensively with Mrc1p.


ensembl_gene_id: YNL263C
symbol: YIF1
gene_biotype: protein_coding
description:
  Integral membrane protein; required for the fusion of ER-derived COPII transport vesicles with the Golgi; interacts with Yip1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles; homolog of human YIPF3; Belongs to the YIF1 family.


ensembl_gene_id: YNL264C
symbol: PDR17
gene_biotype: protein_coding
description:
  Phosphatidylinositol transfer protein (PITP); downregulates Plb1p-mediated turnover of phosphatidylcholine; forms a complex with Psd2p which appears essential for maintenance of vacuolar PE levels; found in the cytosol and microsomes; homologous to Pdr16p; deletion affects phospholipid composition.


ensembl_gene_id: YNL265C
symbol: IST1
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein IST1; Protein with positive role in the multivesicular body sorting pathway; functions and forms a complex with Did2p; recruitment to endosomes is mediated by the Vps2p-Vps24p subcomplex of ESCRT-III; also interacts with Vps4p.


ensembl_gene_id: YNL266W
symbol: YNL266W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YNL266W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF IST1/YNL265C.


ensembl_gene_id: YNL267W
symbol: PIK1
gene_biotype: protein_coding
description:
  Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton; may control nonselective autophagy and mitophagy through trafficking of Atg9p; Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.


ensembl_gene_id: YNL268W
symbol: LYP1
gene_biotype: protein_coding
description:
  Lysine permease; one of three amino acid permeases (Alp1p, Can1p, Lyp1p) responsible for uptake of cationic amino acids.


ensembl_gene_id: YNL269W
symbol: BSC4
gene_biotype: protein_coding
description:
  Bypass of stop codon protein 4; Protein of unknown function; protein-coding gene that evolved de novo via a series of point mutations in noncoding sequence; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; readthrough is increased upon depletion of Sup35p; may be involved in DNA repair pathway during stationary phase and contribute to robustness of cells when shifted to a nutrient-poor environment.


ensembl_gene_id: YNL270C
symbol: ALP1
gene_biotype: protein_coding
description:
  Basic amino-acid permease; Arginine transporter; expression is normally very low and it is unclear what conditions would induce significant expression; ALP1 has a paralog, CAN1, that arose from the whole genome duplication; Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.


ensembl_gene_id: YNL271C
symbol: BNI1
gene_biotype: protein_coding
description:
  Protein BNI1; Formin; polarisome component; nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables; recruited to the division site in a Glc7p/Ref2p dependent manner following release of Bnr1p; functionally redundant with BNR1.


ensembl_gene_id: YNL272C
symbol: SEC2
gene_biotype: protein_coding
description:
  Guanyl-nucleotide exchange factor for the small G-protein Sec4p; essential for post-Golgi vesicle transport and for autophagy; associates with the exocyst, via exocyst subunit Sec15p, on secretory vesicles; Belongs to the SEC2 family.


ensembl_gene_id: YNL273W
symbol: TOF1
gene_biotype: protein_coding
description:
  Topoisomerase 1-associated factor 1; Subunit of a replication-pausing checkpoint complex; Tof1p-Mrc1p-Csm3p acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA; interacts with the MCM helicase; relocalizes to the cytosol in response to hypoxia.


ensembl_gene_id: YNL274C
symbol: GOR1
gene_biotype: protein_coding
description:
  Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.


ensembl_gene_id: YNL275W
symbol: BOR1
gene_biotype: protein_coding
description:
  Boron efflux transporter of the plasma membrane; binds HCO3-, I-, Br-, NO3- and Cl-; has similarity to the characterized boron efflux transporter A. thaliana BOR1.


ensembl_gene_id: YNL276C
symbol: YNL276C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YNL276C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene MET2/YNL277W.


ensembl_gene_id: YNL277W
symbol: MET2
gene_biotype: protein_coding
description:
  L-homoserine-O-acetyltransferase; catalyzes the conversion of homoserine to O-acetyl homoserine which is the first step of the methionine biosynthetic pathway; Belongs to the AB hydrolase superfamily. MetX family.


ensembl_gene_id: YNL278W
symbol: CAF120
gene_biotype: protein_coding
description:
  Part of the CCR4-NOT transcriptional regulatory complex; involved in controlling mRNA initiation, elongation, and degradation; contains a PH-like domain; CAF120 has a paralog, SKG3, that arose from the whole genome duplication.


ensembl_gene_id: YNL279W
symbol: PRM1
gene_biotype: protein_coding
description:
  Plasma membrane fusion protein PRM1; Pheromone-regulated multispanning membrane protein; involved in membrane fusion during mating; predicted to have 5 transmembrane segments and a coiled coil domain; localizes to the shmoo tip; regulated by Ste12p.


ensembl_gene_id: YNL280C
symbol: ERG24
gene_biotype: protein_coding
description:
  C-14 sterol reductase; acts in ergosterol biosynthesis; mutants accumulate the abnormal sterol ignosterol (ergosta-8,14 dienol), and are viable under anaerobic growth conditions but inviable on rich medium under aerobic conditions; Belongs to the ERG4/ERG24 family.


ensembl_gene_id: YNL281W
symbol: HCH1
gene_biotype: protein_coding
description:
  Hsp90 co-chaperone HCH1; Heat shock protein regulator; binds to Hsp90p and may stimulate ATPase activity; originally identified as a high-copy number suppressor of a HSP90 loss-of-function mutation; role in regulating Hsp90 inhibitor drug sensitivity; GFP-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress; Belongs to the AHA1 family.


ensembl_gene_id: YNL282W
symbol: POP3
gene_biotype: protein_coding
description:
  Ribonucleases P/MRP protein subunit POP3; Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; relocalizes to the cytosol in response to hypoxia.


ensembl_gene_id: YNL283C
symbol: WSC2
gene_biotype: protein_coding
description:
  Cell wall integrity and stress response component 2; Sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway; involved in maintenance of cell wall integrity and recovery from heat shock; required for the arrest of secretion response; WSC2 has a paralog, WSC3, that arose from the whole genome duplication.


ensembl_gene_id: YNL284C
symbol: MRPL10
gene_biotype: protein_coding
description:
  Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL10 and YmL18) on two-dimensional SDS gels.


ensembl_gene_id: YNL285W
symbol: YNL285W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YNL285W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YNL286W
symbol: CUS2
gene_biotype: protein_coding
description:
  Putative checkpoint factor in transcription; binds to U2 snRNA and Prp11p; regulates toggling of the U2 snRNA stem II region between different structures; contains two RNA recognition motifs (RRMs).


ensembl_gene_id: YNL287W
symbol: SEC21
gene_biotype: protein_coding
description:
  Gamma subunit of coatomer; coatomer is a heptameric protein complex that together with Arf1p forms the COPI coat; involved in ER to Golgi transport of selective cargo.


ensembl_gene_id: YNL288W
symbol: CAF40
gene_biotype: protein_coding
description:
  Protein CAF40; Component of the CCR4-NOT transcriptional complex; evolutionarily conserved; involved in controlling mRNA initiation, elongation, and degradation; binds Cdc39p.


ensembl_gene_id: YNL289W
symbol: PCL1
gene_biotype: protein_coding
description:
  PHO85 cyclin-1; Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; is ubiquitinated by Dma1p; phosphorylation by Pho85p targets it for degradation; localizes to sites of polarized cell growth.


ensembl_gene_id: YNL290W
symbol: RFC3
gene_biotype: protein_coding
description:
  Subunit of heteropentameric Replication factor C (RF-C); which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon; relocalizes to the cytosol in response to hypoxia.


ensembl_gene_id: YNL291C
symbol: MID1
gene_biotype: protein_coding
description:
  Stretch-activated cation channel MID1; N-glycosylated integral membrane protein of the ER and plasma membrane; functions as a stretch-activated Ca2+-permeable cation channel required for Ca2+ influx stimulated by pheromone; interacts with Cch1p; forms an oligomer.


ensembl_gene_id: YNL292W
symbol: PUS4
gene_biotype: protein_coding
description:
  Pseudouridine synthase; catalyzes only the formation of pseudouridine-55 (Psi55), a highly conserved tRNA modification, in mitochondrial and cytoplasmic tRNAs; also responsible for pseudouracil modification of some mRNAs; PUS4 overexpression leads to translational derepression of GCN4 (Gcd- phenotype).


ensembl_gene_id: YNL293W
symbol: MSB3
gene_biotype: protein_coding
description:
  Rab GTPase-activating protein; regulates endocytosis via inactivation of Vps21p at endosomes and vacuole fusion via inactivation of Ypt7p at vacuoles; also acts on Ypt52p and Sec4p; localizes to plasma membrane, sites of polarized growth; relocalizes from bud neck to cytoplasm upon DNA replication stress; similar to TBC-domain Tre2 oncogene; MSB3 has a paralog, MSB4, that arose from the whole genome duplication; human homolog USP6NL can complement yeast msb3 msb4 double null.


ensembl_gene_id: YNL294C
symbol: RIM21
gene_biotype: protein_coding
description:
  pH-response regulator protein palH/RIM21; pH sensor molecule, component of the RIM101 pathway; has a role in cell wall construction and alkaline pH response; is glycosylated and phosphorylated; interacts with Dfg16p and Rim9p to form a pH-sensing complex; localization to the plasma membrane is dependent on Dfg16p and Rim9p; has similarity to A. nidulans PalH; Belongs to the palH/RIM21 family.


ensembl_gene_id: YNL296W
symbol: YNL296W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YNL296W; Dubious open reading frame unlikely to encode a functional protein; deletion adversely affects sporulation; deletion mutant exhibits synthetic phenotype under expression of mutant huntingtin fragment, but gene does not have human ortholog.


ensembl_gene_id: YNL297C
symbol: MON2
gene_biotype: protein_coding
description:
  Protein with a role in endocytosis and vacuole integrity; peripheral membrane protein; interacts with and negatively regulates Arl1p; localizes to the endosome; member of the Sec7p family of proteins.


ensembl_gene_id: YNL298W
symbol: CLA4
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase CLA4; Cdc42p-activated signal transducing kinase; member of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p; CLA4 has a paralog, SKM1, that arose from the whole genome duplication.


ensembl_gene_id: YNL299W
symbol: TRF5
gene_biotype: protein_coding
description:
  Non-canonical poly(A) polymerase; involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Pap2p.


ensembl_gene_id: YNL300W
symbol: TOS6
gene_biotype: protein_coding
description:
  Protein TOS6; Glycosylphosphatidylinositol-dependent cell wall protein; expression is periodic and decreases in respone to ergosterol perturbation or upon entry into stationary phase; depletion increases resistance to lactic acid.


ensembl_gene_id: YNL301C
symbol: RPL18B
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L18B; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18B has a paralog, RPL18A, that arose from the whole genome duplication.


ensembl_gene_id: YNL302C
symbol: RPS19B
gene_biotype: protein_coding
description:
  Protein component of the small (40S) ribosomal subunit; required for assembly and maturation of pre-40 S particles; homologous to mammalian ribosomal protein S19, no bacterial homolog; mutations in human RPS19 are associated with Diamond Blackfan anemia; RPS19B has a paralog, RPS19A, that arose from the whole genome duplication.


ensembl_gene_id: YNL303W
symbol: YNL303W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YNL303W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YNL304W
symbol: YPT11
gene_biotype: protein_coding
description:
  GTP-binding protein YPT11; Rab GTPase; Myo2p-binding protein implicated in mother-to-bud transport of cortical endoplasmic reticulum (ER), late Golgi, and mitochondria during cell division; function is regulated at multiple levels; abundance of active Ypt11p forms is controlled by phosphorylation status and degradation; normally a low-abundance protein whose ER localization is only detected when protein is highly over expressed.


ensembl_gene_id: YNL305C
symbol: BXI1
gene_biotype: protein_coding
description:
  Bax inhibitor 1; Protein involved in apoptosis; variously described as containing a BCL-2 homology (BH3) domain or as a member of the BAX inhibitor family; reported to promote apoptosis under some conditions and to inhibit it in others; localizes to ER and vacuole; may link the unfolded protein response to apoptosis via regulation of calcium-mediated signaling; translocates to mitochondria under apoptosis-inducing conditions in a process involving Mir1p and Cor1p; Belongs to the BI1 family. LFG subfamily.


ensembl_gene_id: YNL306W
symbol: MRPS18
gene_biotype: protein_coding
description:
  Mitochondrial ribosomal protein of the small subunit; essential for viability, unlike most other mitoribosomal proteins.


ensembl_gene_id: YNL307C
symbol: MCK1
gene_biotype: protein_coding
description:
  Protein kinase MCK1; Dual-specificity ser/thr and tyrosine protein kinase; roles in chromosome segregation, meiotic entry, genome stability, phosphorylation-dependent protein degradation (Rcn1p and Cdc6p), inhibition of protein kinase A, transcriptional regulation, inhibition of RNA pol III, calcium stress and inhibition of Clb2p-Cdc28p after nuclear division; MCK1 has a paralog, YGK3, that arose from the whole genome duplication.


ensembl_gene_id: YNL308C
symbol: KRI1
gene_biotype: protein_coding
description:
  Protein KRI1; Essential nucleolar protein required for 40S ribosome biogenesis; associate with snR30; physically and functionally interacts with Krr1p; Belongs to the KRI1 family.


ensembl_gene_id: YNL309W
symbol: STB1
gene_biotype: protein_coding
description:
  Protein with role in regulation of MBF-specific transcription at Start; phosphorylated by Cln-Cdc28p kinases in vitro; unphosphorylated form binds Swi6p, which is required for Stb1p function; expression is cell-cycle regulated; STB1 has a paralog, YOL131W, that arose from the whole genome duplication.


ensembl_gene_id: YNL310C
symbol: ZIM17
gene_biotype: protein_coding
description:
  Protein co-chaperone with a zinc finger motif; essential for protein import into mitochondria; may act with Pam18p to facilitate recognition and folding of imported proteins by Ssc1p (mtHSP70) in the mitochondrial matrix; required for the maintenance of Ssc1p solubility and assists in the functional interaction of Ssc1p with substrate proteins.


ensembl_gene_id: YNL311C
symbol: SKP2
gene_biotype: protein_coding
description:
  F-box protein of unknown function; predicted to be part of an SCF ubiquitin protease complex; involved in regulating protein levels of sulfur metabolism enzymes; may interact with ribosomes, based on co-purification experiments.


ensembl_gene_id: YNL312W
symbol: RFA2
gene_biotype: protein_coding
description:
  Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination; RPA protects against inappropriate telomere recombination, and upon telomere uncapping, prevents cell proliferation by a checkpoint-independent pathway; in concert with Sgs1p-Top2p-Rmi1p, stimulates DNA catenation/decatenation activity of Top3p; protein abundance increases in response to DNA replication s.


ensembl_gene_id: YNL313C
symbol: EMW1
gene_biotype: protein_coding
description:
  Essential for maintenance of the cell wall protein 1; Essential conserved protein with a role in cell wall integrity; contains six TPR (tetratricopeptide repeat) domains clustered in the C-terminal region; conditional mutant is suppressed by overexpression of GFA1; protein abundance increases in response to DNA replication stress; Belongs to the TTC27 family.


ensembl_gene_id: YNL314W
symbol: DAL82
gene_biotype: protein_coding
description:
  Protein DAL82; Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain.


ensembl_gene_id: YNL315C
symbol: ATP11
gene_biotype: protein_coding
description:
  Protein ATP11, mitochondrial; Molecular chaperone; required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase; N-terminally propionylated in vivo.


ensembl_gene_id: YNL316C
symbol: PHA2
gene_biotype: protein_coding
description:
  Prephenate dehydratase; catalyzes the conversion of prephanate to phenylpyruvate, which is a step in the phenylalanine biosynthesis pathway.


ensembl_gene_id: YNL317W
symbol: PFS2
gene_biotype: protein_coding
description:
  Polyadenylation factor subunit 2; Integral subunit of the pre-mRNA CPF complex; the cleavage and polyadenylation factor (CPF) complex plays an essential role in mRNA 3'-end formation by bridging different processing factors and thereby promoting the assembly of the processing complex.


ensembl_gene_id: YNL318C
symbol: HXT14
gene_biotype: protein_coding
description:
  Protein with similarity to hexose transporter family members; expression is induced in low glucose and repressed in high glucose; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.


ensembl_gene_id: YNL319W
symbol: YNL319W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YNL319W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HXT14.


ensembl_gene_id: YNL320W
symbol: YNL320W
gene_biotype: protein_coding
description:
  Uncharacterized membrane protein YNL320W; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; To S.pombe bem46 and M.tuberculosis Rv2307c.


ensembl_gene_id: YNL321W
symbol: VNX1
gene_biotype: protein_coding
description:
  Low affinity vacuolar monovalent cation/H(+) antiporter; Calcium/H+ antiporter localized to the endoplasmic reticulum membrane; member of the calcium exchanger (CAX) family; potential Cdc28p substrate; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.


ensembl_gene_id: YNL322C
symbol: KRE1
gene_biotype: protein_coding
description:
  Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor.


ensembl_gene_id: YNL323W
symbol: LEM3
gene_biotype: protein_coding
description:
  Alkylphosphocholine resistance protein LEM3; Membrane protein of the plasma membrane and ER; interacts specifically in vivo with the phospholipid translocase (flippase) Dnf1p; involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane; null mutant requires tryptophan due to mislocalization of tryptophan permease Tat2p.


ensembl_gene_id: YNL324W
symbol: YNL324W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YNL324W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YNL325C
symbol: FIG4
gene_biotype: protein_coding
description:
  Phosphatidylinositol 3,5-bisphosphate (PtdIns[3,5]P) phosphatase; required for efficient mating and response to osmotic shock; physically associates with and regulated by Vac14p; contains a SAC1-like domain; homologous to human FIG4, which is associated with CMT4J, a form of Charcot-Marie-Tooth disorder.


ensembl_gene_id: YNL326C
symbol: PFA3
gene_biotype: protein_coding
description:
  Palmitoyltransferase for Vac8p; required for vacuolar membrane fusion; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; autoacylates; required for vacuolar integrity under stress conditions; Belongs to the DHHC palmitoyltransferase family. PFA3 subfamily.


ensembl_gene_id: YNL327W
symbol: EGT2
gene_biotype: protein_coding
description:
  Protein EGT2; Glycosylphosphatidylinositol (GPI)-anchored cell wall endoglucanase; required for proper cell separation after cytokinesis; expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner.


ensembl_gene_id: YNL328C
symbol: MDJ2
gene_biotype: protein_coding
description:
  Mitochondrial DnaJ homolog 2; Constituent of the mitochondrial import motor; associated with the presequence translocase; function overlaps with that of Pam18p; stimulates the ATPase activity of Ssc1p to drive mitochondrial import; contains a J domain.


ensembl_gene_id: YNL329C
symbol: PEX6
gene_biotype: protein_coding
description:
  Peroxisomal ATPase PEX6; AAA-peroxin; heterodimerizes with AAA-peroxin Pex1p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol; mutations in human PEX6 can lead to severe peroxisomal disorders and early death.


ensembl_gene_id: YNL330C
symbol: RPD3
gene_biotype: protein_coding
description:
  Histone deacetylase, component of both the Rpd3S and Rpd3L complexes; regulates transcription, silencing, autophagy and other processes by influencing chromatin remodeling; forms at least two different complexes which have distinct functions and members; Rpd3(L) recruitment to the subtelomeric region is regulated by interaction with the arginine methyltransferase, Hmt1p.


ensembl_gene_id: YNL331C
symbol: AAD14
gene_biotype: protein_coding
description:
  Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role; members of the AAD gene family comprise three pairs (AAD3 + AAD15, AAD6/AAD16 + AAD4, AAD10 + AAD14) whose two genes are more related to one another than to other members of the family.


ensembl_gene_id: YNL332W
symbol: THI12
gene_biotype: protein_coding
description:
  4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase THI12; Protein involved in synthesis of the thiamine precursor HMP; member of a subtelomeric gene family including THI5, THI11, THI12, and THI13; hydroxymethylpyrimidine is also known as HMP; Belongs to the NMT1/THI5 family.


ensembl_gene_id: YNL333W
symbol: SNZ2
gene_biotype: protein_coding
description:
  Probable pyridoxal 5'-phosphate synthase subunit SNZ2; Member of a stationary phase-induced gene family; transcription of SNZ2 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO2; interacts with Thi11p.


ensembl_gene_id: YNL334C
symbol: SNO2
gene_biotype: protein_coding
description:
  Probable pyridoxal 5'-phosphate synthase subunit SNO2; Protein of unknown function; nearly identical to Sno3p; expression is induced before the diauxic shift and also in the absence of thiamin; Belongs to the glutaminase PdxT/SNO family.


ensembl_gene_id: YNL335W
symbol: DDI3
gene_biotype: protein_coding
description:
  Cyanamide hydratase that detoxifies cyanamide; member of the HD domain metalloprotein superfamily; expression is induced over 100-fold by cyanamide and by SN2-type DNA alkylating agents such as MMS and DMA; induction decreased in rad6 and rad18 mutants; gene and protein are identical to DDI2 and Ddi2p.


ensembl_gene_id: YNL337W
symbol: YNL337W
gene_biotype: protein_coding
description:
  Putative UPF0320 protein YNL337W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YNL338W
symbol: YNL338W
gene_biotype: protein_coding
description:
  Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps TEL14L-XC, which is a telomeric X element core sequence on the left arm of chromosome XIV.


ensembl_gene_id: YNL339C
symbol: YRF1-6
gene_biotype: protein_coding
description:
  Y' element ATP-dependent helicase protein 1 copy 6; Helicase encoded by the Y' element of subtelomeric regions; highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p.


ensembl_gene_id: YNL339W-A
symbol: YNL339W-A
gene_biotype: protein_coding
description:
  Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching.


ensembl_gene_id: YNR001C
symbol: CIT1
gene_biotype: protein_coding
description:
  Citrate synthase, mitochondrial; Citrate synthase; catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein; CIT1 has a paralog, CIT2, that arose from the whole genome duplication.


ensembl_gene_id: YNR001W-A
symbol: YNR001W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YNR001W-A; Dubious open reading frame unlikely to encode a functional protein; identified by homology.


ensembl_gene_id: YNR002C
symbol: ATO2
gene_biotype: protein_coding
description:
  Ammonia transport outward protein 2; Putative transmembrane protein involved in export of ammonia; ammonia is a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Y. lipolytica Gpr1p; ATO2 has a paralog, ADY2, that arose from the whole genome duplication.


ensembl_gene_id: YNR003C
symbol: RPC34
gene_biotype: protein_coding
description:
  RNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex; Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.


ensembl_gene_id: YNR003W-A
symbol: YNR003W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YNR003W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the verified gene RPC34/YNR003C.


ensembl_gene_id: YNR004W
symbol: SWM2
gene_biotype: protein_coding
description:
  Nucleolar protein SWM2; Protein with a role in snRNA and snoRNA cap trimethylation; interacts with Tgs1p and shows similar phenotypes; required for trimethylation of the caps of spliceosomal snRNAs and the U3 snoRNA, and for efficient 3' end processing of U3 snoRNA; may act as a specificity factor for Tgs1p; Belongs to the SWM2 family.


ensembl_gene_id: YNR005C
symbol: YNR005C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YNR005C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YNR006W
symbol: VPS27
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 27; Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiquitin (Ubi4p).


ensembl_gene_id: YNR007C
symbol: ATG3
gene_biotype: protein_coding
description:
  Autophagy-related protein 3; E2-like enzyme; involved in autophagy and cytoplasm-to-vacuole targeting (Cvt) pathway; plays a role in formation of Atg8p-phosphatidylethanolamine conjugates, which are involved in membrane dynamics during autophagy and Cvt; interaction with Atg8p regulated by acetylation by NuA4 histone acetyltransferase Esa1p while attenuation of Atg3 acetylation is mediated by histone deacetylase Rpd3p; Atg12p-Atg5p conjugate enhances E2 activity of Atg3p by rearranging its catalytic site.


ensembl_gene_id: YNR008W
symbol: LRO1
gene_biotype: protein_coding
description:
  Acyltransferase that catalyzes diacylglycerol esterification; one of several acyltransferases that contribute to triglyceride synthesis; Lro1p and Dga1p can O-acylate ceramides; putative homolog of human lecithin cholesterol acyltransferase.


ensembl_gene_id: YNR009W
symbol: NRM1
gene_biotype: protein_coding
description:
  Transcription factor NRM1; Transcriptional co-repressor of MBF-regulated gene expression; Nrm1p associates stably with promoters via MCB binding factor (MBF) to repress transcription upon exit from G1 phase.


ensembl_gene_id: YNR010W
symbol: CSE2
gene_biotype: protein_coding
description:
  Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; component of the Middle domain of mediator; required for regulation of RNA polymerase II activity; relocalizes to the cytosol in response to hypoxia.


ensembl_gene_id: YNR011C
symbol: PRP2
gene_biotype: protein_coding
description:
  Pre-mRNA-splicing factor ATP-dependent RNA helicase-like protein PRP2; RNA-dependent DExD/H-box ATPase; required for activation of spliceosome before first transesterification step in RNA splicing; implicated in rearranging and proofreading snRNA structure in catalytic activation of spliceosome; ortholog of human protein DHX16.


ensembl_gene_id: YNR012W
symbol: URK1
gene_biotype: protein_coding
description:
  Uridine/cytidine kinase; component of the pyrimidine ribonucleotide salvage pathway that converts uridine into UMP and cytidine into CMP; involved in the pyrimidine deoxyribonucleotide salvage pathway, converting deoxycytidine into dCMP.


ensembl_gene_id: YNR013C
symbol: PHO91
gene_biotype: protein_coding
description:
  Low-affinity vacuolar phosphate transporter; exports phosphate from the vacuolar lumen to the cytosol; regulates phosphate and polyphosphate metabolism; acts upstream of Pho81p in regulation of the PHO pathway; localizes to sites of contact between the vacuole and mitochondria (vCLAMPs); deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth.


ensembl_gene_id: YNR014W
symbol: YNR014W
gene_biotype: protein_coding
description:
  Uncharacterized protein YNR014W; Putative protein of unknown function; expression is cell-cycle regulated, Azf1p-dependent, and heat-inducible; YNR014W has a paralog, YMR206W, that arose from the whole genome duplication.


ensembl_gene_id: YNR015W
symbol: SMM1
gene_biotype: protein_coding
description:
  tRNA-dihydrouridine(20) synthase [NAD(P)+]; Dihydrouridine synthase; member of a family of dihydrouridine synthases including Dus1p, Smm1p, Dus3p, and Dus4p; modifies uridine residues at position 20 of cytoplasmic tRNAs; Belongs to the Dus family. Dus2 subfamily.


ensembl_gene_id: YNR016C
symbol: ACC1
gene_biotype: protein_coding
description:
  Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availablity of acetyl-CoA; required for de novo biosynthesis of long-chain fatty acids; ACC1 has a paralog, HFA1, that arose from the whole genome duplication.


ensembl_gene_id: YNR017W
symbol: TIM23
gene_biotype: protein_coding
description:
  Essential component of the TIM23 complex; involved in protein import into mitochondrial matrix and inner membrane; with Tim17p, contributes to architecture and function of the import channel; TIM23 complex is short for the translocase of the inner mitochondrial membrane.


ensembl_gene_id: YNR018W
symbol: RCF2
gene_biotype: protein_coding
description:
  Respiratory supercomplex factor 2, mitochondrial; Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast.


ensembl_gene_id: YNR019W
symbol: ARE2
gene_biotype: protein_coding
description:
  Sterol O-acyltransferase 2; Acyl-CoA:sterol acyltransferase; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the presence of oxygen; ARE2 has a paralog, ARE1, that arose from the whole genome duplication.


ensembl_gene_id: YNR020C
symbol: ATP23
gene_biotype: protein_coding
description:
  Putative metalloprotease of the mitochondrial inner membrane; required for processing of Atp6p; has an additional role in assembly of the F0 sector of the F1F0 ATP synthase complex; substrate of the Mia40p-Erv1p disulfide relay system, and folding is assisted by Mia40p; Belongs to the peptidase M76 family.


ensembl_gene_id: YNR021W
symbol: YNR021W
gene_biotype: protein_coding
description:
  UPF0674 endoplasmic reticulum membrane protein YNR021W; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNR021W is not an essential gene; Belongs to the UPF0674 family.


ensembl_gene_id: YNR023W
symbol: SNF12
gene_biotype: protein_coding
description:
  Transcription regulatory protein SNF12; 73 kDa subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; relocates to the cytosol under hypoxic conditions; deletion mutants are temperature-sensitive; SNF12 has a paralog, RSC6, that arose from the whole genome duplication.


ensembl_gene_id: YNR024W
symbol: MPP6
gene_biotype: protein_coding
description:
  M-phase phosphoprotein 6 homolog; Nuclear exosome-associated RNA binding protein; involved in surveillance of pre-rRNAs and pre-mRNAs, and the degradation of cryptic non-coding RNAs (ncRNA); copurifies with ribosomes; relocalizes to the cytosol in response to hypoxia.


ensembl_gene_id: YNR025C
symbol: YNR025C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YNR025C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion reduces expression of PIS1 gene encoding phosphatidylinositol synthase.


ensembl_gene_id: YNR026C
symbol: SEC12
gene_biotype: protein_coding
description:
  Guanine nucleotide exchange factor (GEF); activates Sar1p by catalyzing the exchange of GDP for GTP; required for the initiation of COPII vesicle formation in ER to Golgi transport; glycosylated integral membrane protein of the ER; SEC12 has a paralog, SED4, that arose from the whole genome duplication; Belongs to the WD repeat SEC12 family.


ensembl_gene_id: YNR027W
symbol: BUD17
gene_biotype: protein_coding
description:
  Putative pyridoxal kinase; a key enzyme in vitamin B6 metabolism; involved in bud-site selection; diploid mutants display a random rather than a bipolar budding pattern; similarity to yeast BUD16 and human pyridoxal kinase (PDXK).


ensembl_gene_id: YNR028W
symbol: CPR8
gene_biotype: protein_coding
description:
  Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; potential role in the secretory pathway; CPR8 has a paralog, CPR4, that arose from the whole genome duplication.


ensembl_gene_id: YNR029C
symbol: YNR029C
gene_biotype: protein_coding
description:
  Uncharacterized protein YNR029C; Putative protein of unknown function; deletion confers reduced fitness in saline.


ensembl_gene_id: YNR030W
symbol: ALG12
gene_biotype: protein_coding
description:
  Alpha-1,6-mannosyltransferase localized to the ER; responsible for addition of alpha-1,6 mannose to dolichol-linked Man7GlcNAc2; acts in the dolichol pathway for N-glycosylation; human homolog ALG12 complements yeast null mutant.


ensembl_gene_id: YNR031C
symbol: SSK2
gene_biotype: protein_coding
description:
  MAP kinase kinase kinase of HOG1 mitogen-activated signaling pathway; interacts with Ssk1p, leading to autophosphorylation and activation of Ssk2p which phosphorylates Pbs2p; also mediates actin cytoskeleton recovery from osmotic stress; a HOG-independent function of Ssk2p mediates the calcium-sensitive phenotype of the ptp2 msg5 double disruptant; SSK2 has a paralog, SSK22, that arose from the whole genome duplication.


ensembl_gene_id: YNR032C-A
symbol: HUB1
gene_biotype: protein_coding
description:
  Ubiquitin-like protein modifier; promotes alternative splicing of SRC1 pre-mRNA; binds non-covalently to the HIND domain of Snu66, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear.


ensembl_gene_id: YNR032W
symbol: PPG1
gene_biotype: protein_coding
description:
  Serine/threonine-protein phosphatase PP2A-like PPG1; Putative serine/threonine protein phosphatase; putative phosphatase of the type 2A-like phosphatase family, required for glycogen accumulation; interacts with Tap42p, which binds to and regulates other protein phosphatases.


ensembl_gene_id: YNR033W
symbol: ABZ1
gene_biotype: protein_coding
description:
  Para-aminobenzoate (PABA) synthase; has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YNR034W
symbol: SOL1
gene_biotype: protein_coding
description:
  6-phosphogluconolactonase-like protein 1; Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol3p and Sol4p; SOL1 has a paralog, SOL2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress; Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.


ensembl_gene_id: YNR034W-A
symbol: EGO4
gene_biotype: protein_coding
description:
  Uncharacterized protein YNR034W-A; Protein of unknown function; expression is regulated by Msn2p/Msn4p; YNR034W-A has a paralog, YCR075W-A, that arose from the whole genome duplication.


ensembl_gene_id: YNR035C
symbol: ARC35
gene_biotype: protein_coding
description:
  Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches; required for cortical localization of calmodulin.


ensembl_gene_id: YNR036C
symbol: MRPS12
gene_biotype: protein_coding
description:
  37S ribosomal protein S12, mitochondrial; Mitochondrial protein; may interact with ribosomes based on co-purification experiments; similar to E. coli and human mitochondrial S12 ribosomal proteins; Belongs to the universal ribosomal protein uS12 family.


ensembl_gene_id: YNR037C
symbol: RSM19
gene_biotype: protein_coding
description:
  Mitochondrial ribosomal protein of the small subunit; has similarity to E. coli S19 ribosomal protein.


ensembl_gene_id: YNR038W
symbol: DBP6
gene_biotype: protein_coding
description:
  ATP-dependent RNA helicase DBP6; Essential protein involved in ribosome biogenesis; putative ATP-dependent RNA helicase of the DEAD-box protein family; human homolog DDX51 complements yeast dbp6 mutant.


ensembl_gene_id: YNR039C
symbol: ZRG17
gene_biotype: protein_coding
description:
  Protein ZRG17; Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Msc2p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; zinc-regulated directly through Zap1p; transcription induced under conditions of zinc deficiency.


ensembl_gene_id: YNR040W
symbol: YNR040W
gene_biotype: protein_coding
description:
  Uncharacterized protein YNR040W; Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies.


ensembl_gene_id: YNR041C
symbol: COQ2
gene_biotype: protein_coding
description:
  4-hydroxybenzoate polyprenyltransferase, mitochondrial; Para hydroxybenzoate polyprenyl transferase; catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis; human COQ2, mutations in which are implicated in an increased risk of mutiple-system atrophy, can complement a yeast coq2 null mutant.


ensembl_gene_id: YNR042W
symbol: YNR042W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YNR042W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2.


ensembl_gene_id: YNR043W
symbol: MVD1
gene_biotype: protein_coding
description:
  Mevalonate pyrophosphate decarboxylase; essential enzyme involved in the biosynthesis of isoprenoids and sterols, including ergosterol; acts as a homodimer; Belongs to the diphosphomevalonate decarboxylase family.


ensembl_gene_id: YNR044W
symbol: AGA1
gene_biotype: protein_coding
description:
  Anchorage subunit of a-agglutinin of a-cells; highly O-glycosylated protein with N-terminal secretion signal and C-terminal signal for addition of GPI anchor to cell wall, linked to adhesion subunit Aga2p via two disulfide bonds; AGA1 has a paralog, FIG2, that arose from the whole genome duplication.


ensembl_gene_id: YNR045W
symbol: PET494
gene_biotype: protein_coding
description:
  Mitochondrial translational activator specific for the COX3 mRNA; acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane.


ensembl_gene_id: YNR046W
symbol: TRM112
gene_biotype: protein_coding
description:
  Multifunctional methyltransferase subunit TRM112; Protein involved in methylation of tRNA, rRNA, and translation factors; also involved in ribosome biogenesis; subunit of tRNA methyltransferase (MTase) complexes in combination with Trm9p and Trm11p; N7-methylates G1575 of 18S rRNA as complex with Bud23p; subunit of complex with Mtq2p that methylates Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; relative distribution to the nucleus increases upon DNA replication stress; functional homolog of human TRMT112.


ensembl_gene_id: YNR047W
symbol: FPK1
gene_biotype: protein_coding
description:
  Flippase kinase 1; Ser/Thr protein kinase; phosphorylates several aminophospholipid translocase family members, regulating phospholipid translocation and membrane asymmetry; phosphorylates and inhibits upstream inhibitory kinase, Ypk1p; localizes to the cytoplasm, early endosome/TGN compartments and thplasma membrane; localizes to the shmoo tip where it has a redundant role in the cellular response to mating pheromone; FPK1 has a paralog, KIN82, that arose from the whole genome duplication.


ensembl_gene_id: YNR048W
symbol: YNR048W
gene_biotype: protein_coding
description:
  Potential noncatalytic subunit for phospholipid translocase Dnf3p; YNR048W has a paralog, CDC50, that arose from the whole genome duplication.


ensembl_gene_id: YNR049C
symbol: MSO1
gene_biotype: protein_coding
description:
  Protein MSO1; Lipid-interacting protein in SNARE complex assembly machinery; acts at late step in secretion; interacts with membranes through two distinct binding sites; shows genetic and physical interactions with Sec1p; required for prospore membrane formation during sporulation; N-terminus closely associates with plasma membrane, C-terminus colocalizes with Sec4p on intracellular membranes; relocalizes from bud neck to nucleus upon DNA replication stress.


ensembl_gene_id: YNR050C
symbol: LYS9
gene_biotype: protein_coding
description:
  Saccharopine dehydrogenase (NADP+, L-glutamate-forming); catalyzes the formation of saccharopine from alpha-aminoadipate 6-semialdehyde, the seventh step in lysine biosynthesis pathway; exhibits genetic and physical interactions with TRM112.


ensembl_gene_id: YNR051C
symbol: BRE5
gene_biotype: protein_coding
description:
  UBP3-associated protein BRE5; Ubiquitin protease cofactor; forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Golgi compartments; null is sensitive to brefeldin A.


ensembl_gene_id: YNR052C
symbol: POP2
gene_biotype: protein_coding
description:
  Poly(A) ribonuclease POP2; RNase of the DEDD superfamily; subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation.


ensembl_gene_id: YNR053C
symbol: NOG2
gene_biotype: protein_coding
description:
  Nucleolar GTP-binding protein 2; Putative GTPase; associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation; recruited by ribosomal proteins L17, L35, and L37 to assembling ribosomes after 27SB pre-rRNA is generated, immediately preceding removal of ITS2; Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.


ensembl_gene_id: YNR054C
symbol: ESF2
gene_biotype: protein_coding
description:
  Pre-rRNA-processing protein ESF2; Essential nucleolar protein involved in pre-18S rRNA processing; binds to RNA and stimulates ATPase activity of Dbp8; involved in assembly of the small subunit (SSU) processome.


ensembl_gene_id: YNR055C
symbol: HOL1
gene_biotype: protein_coding
description:
  Protein HOL1; Putative transporter in the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; mutations in membrane-spanning domains permit cation and histidinol uptake.


ensembl_gene_id: YNR056C
symbol: BIO5
gene_biotype: protein_coding
description:
  7-keto 8-aminopelargonic acid transporter; Putative transmembrane protein involved in the biotin biosynthesis; responsible for uptake of 7-keto 8-aminopelargonic acid; BIO5 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; Belongs to the amino acid-polyamine-organocation (APC) superfamily.


ensembl_gene_id: YNR057C
symbol: BIO4
gene_biotype: protein_coding
description:
  Dethiobiotin synthetase; catalyzes the third step in the biotin biosynthesis pathway; BIO4 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; BIO3 and BIO4 were acquired by horizontal gene transfer (HGT) from bacteria; expression appears to be repressed at low iron levels.


ensembl_gene_id: YNR058W
symbol: BIO3
gene_biotype: protein_coding
description:
  7,8-diamino-pelargonic acid aminotransferase (DAPA); catalyzes the second step in the biotin biosynthesis pathway; BIO3 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; BIO3 and BIO4 were acquired by horizontal gene transfer (HGT) from bacteria; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.


ensembl_gene_id: YNR059W
symbol: MNT4
gene_biotype: protein_coding
description:
  Probable alpha-1,3-mannosyltransferase MNT4; Putative alpha-1,3-mannosyltransferase; not required for protein O-glycosylation; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively.


ensembl_gene_id: YNR060W
symbol: FRE4
gene_biotype: protein_coding
description:
  Ferric reductase transmembrane component 4; Ferric reductase; reduces a specific subset of siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels.


ensembl_gene_id: YNR061C
symbol: YNR061C
gene_biotype: protein_coding
description:
  Uncharacterized vacuolar membrane protein YNR061C; Protein of unknown function; relocalizes from vacuole to cytoplasm upon DNA replication stress.


ensembl_gene_id: YNR063W
symbol: YNR063W
gene_biotype: protein_coding
description:
  Uncharacterized transcriptional regulatory protein YNR063W; Putative zinc-cluster protein of unknown function.


ensembl_gene_id: YNR064C
symbol: YNR064C
gene_biotype: protein_coding
description:
  Uncharacterized hydrolase YNR064C; Epoxide hydrolase; member of the alpha/beta hydrolase fold family; may have a role in detoxification of epoxides; Belongs to the DmpD/TodF/XylF esterase family.


ensembl_gene_id: YNR065C
symbol: YNR065C
gene_biotype: protein_coding
description:
  Uncharacterized membrane glycoprotein YNR065C; Protein of unknown function; protein-protein interactions suggest a possible role in actin patch formation; YNR065C is not an essential gene.


ensembl_gene_id: YNR066C
symbol: YNR066C
gene_biotype: protein_coding
description:
  Uncharacterized membrane glycoprotein YNR066C; Putative membrane-localized protein of unknown function.


ensembl_gene_id: YNR067C
symbol: DSE4
gene_biotype: protein_coding
description:
  Endo-1,3(4)-beta-glucanase 1; Daughter cell-specific secreted protein with similarity to glucanases; degrades cell wall from the daughter side causing daughter to separate from mother.


ensembl_gene_id: YNR068C
symbol: YNR068C
gene_biotype: protein_coding
description:
  Uncharacterized protein YNR068C; Putative protein of unknown function; exhibits homology to C-terminal end of Bul1p; expressed as a readthrough product of BSC5, the readthrough locus being termed BUL3; the BUL3 readthrough product is involved in ubiquitin-mediated sorting of plasma membrane proteins and interacts with WW domains of Rsp5p in vitro, but in a functionally different way than the non-readthrough form.


ensembl_gene_id: YNR069C
symbol: BSC5
gene_biotype: protein_coding
description:
  Bypass of stop codon protein 5; Protein of unknown function; shows homology with N-terminal end of Bul1p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; readthrough expression includes YNR068C and the locus for this readthrough is termed BUL3; Bul3p is involved in ubiquitin-mediated sorting of plasma membrane proteins; readthrough and shortened forms of Bul3p interact with Rsp5p differently in vitro; Belongs to the BUL1 family.


ensembl_gene_id: YNR070W
symbol: PDR18
gene_biotype: protein_coding
description:
  Putative transporter of the ATP-binding cassette (ABC) family; role in plasma membrane sterol incorporation; implicated in pleiotropic drug resistance; provides resistance to ethanol stress and contributes to a decreased intracellular accumulation of ethanol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.


ensembl_gene_id: YNR071C
symbol: YNR071C
gene_biotype: protein_coding
description:
  Uncharacterized isomerase YNR071C; Putative aldose 1-epimerase; Belongs to the aldose epimerase family.


ensembl_gene_id: YNR072W
symbol: HXT17
gene_biotype: protein_coding
description:
  Hexose transporter HXT17; Putative transmembrane polyol transporter; supports growth on and uptake of mannitol and sorbitol with moderate affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; induced by raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose; HXT17 has a paralog, HXT13, that arose from a segmental duplication; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.


ensembl_gene_id: YNR074C
symbol: AIF1
gene_biotype: protein_coding
description:
  Apoptosis-inducing factor 1; Mitochondrial cell death effector; translocates to the nucleus in response to apoptotic stimuli, homolog of mammalian Apoptosis-Inducing Factor, putative reductase; Belongs to the FAD-dependent oxidoreductase family.


ensembl_gene_id: YNR075C-A
symbol: YNR075C-A
gene_biotype: protein_coding
description:
  Putative UPF0377 protein YNR075C-A; Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; Belongs to the UPF0377 family.


ensembl_gene_id: YNR076W
symbol: PAU6
gene_biotype: protein_coding
description:
  Member of the seripauperin multigene family; encoded mainly in subtelomeric regions; SWAT-GFP fusion protein localizes to the endoplasmic reticulum and vacuole, while mCherry fusion localizes to just the vacuole; active during alcoholic fermentation; regulated by anaerobiosis; negatively regulated by oxygen; repressed by heme; identical to Pau18p.


ensembl_gene_id: YOL001W
symbol: PHO80
gene_biotype: protein_coding
description:
  PHO85 cyclin PHO80; Cyclin; interacts with cyclin-dependent kinase Pho85p; regulates the response to nutrient levels and environmental conditions, including the response to phosphate limitation and stress-dependent calcium signaling; Belongs to the cyclin family. PHO80 subfamily.


ensembl_gene_id: YOL002C
symbol: IZH2
gene_biotype: protein_coding
description:
  ADIPOR-like receptor IZH2; Plasma membrane receptor for plant antifungal osmotin; involved in zinc ion homeostasis, apoptosis; negatively regulates ZRT1 and other functionally divergent genes through CCCTC promoter motif (IzRE); modulates FET3 activity in iron-independent manner; affects gene expression by influencing balance of competition between Msn2p/Msn4p and Nrg1p/Nrg2p for binding to IzRE; transcription regulated by Zap1p, zinc, fatty acid levels; homolog of mammalian adiponectin receptor.


ensembl_gene_id: YOL003C
symbol: PFA4
gene_biotype: protein_coding
description:
  Palmitoyltransferase with autoacylation activity; required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases.


ensembl_gene_id: YOL004W
symbol: SIN3
gene_biotype: protein_coding
description:
  Transcriptional regulatory protein SIN3; Component of both the Rpd3S and Rpd3L histone deacetylase complexes; involved in transcriptional repression and activation of diverse processes, including mating-type switching and meiosis; involved in the maintenance of chromosomal integrity.


ensembl_gene_id: YOL005C
symbol: RPB11
gene_biotype: protein_coding
description:
  RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit.


ensembl_gene_id: YOL006C
symbol: TOP1
gene_biotype: protein_coding
description:
  DNA topoisomerase 1; Topoisomerase I; nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination; role in processing ribonucleoside monophosphates in genomic DNA into irreversible single-strand breaks; enzymatic activity and interaction with Nsr1p are negatively regulated by polyphosphorylation.


ensembl_gene_id: YOL007C
symbol: CSI2
gene_biotype: protein_coding
description:
  Chitin synthase 3 complex protein CSI2; Protein of unknown function; green fluorescent protein (GFP)- fusion protein localizes to the mother side of the bud neck and the vacuole; YOL007C is not an essential gene.


ensembl_gene_id: YOL008W
symbol: COQ10
gene_biotype: protein_coding
description:
  Coenzyme Q-binding protein COQ10, mitochondrial; Coenzyme Q (ubiquinone) binding protein; functions in the delivery of Q<sub>6</sub> to its proper location for electron transport during respiration; START domain protein with homologs in bacteria and eukaryotes; respiratory growth defect of the null mutant is functionally complemented by human COQ10A.


ensembl_gene_id: YOL009C
symbol: MDM12
gene_biotype: protein_coding
description:
  Mitochondrial distribution and morphology protein 12; Mitochondrial outer membrane protein, ERMES complex subunit; required for transmission of mitochondria to daughter cells; required for mitophagy; may influence import and assembly of outer membrane beta-barrel proteins; ERMES complex is often co-localized with peroxisomes and with concentrated areas of pyruvate dehydrogenase; Belongs to the MDM12 family.


ensembl_gene_id: YOL010W
symbol: RCL1
gene_biotype: protein_coding
description:
  RNA 3'-terminal phosphate cyclase-like protein; Endonuclease that cleaves pre-rRNA at site A2 for 18S rRNA biogenesis; subunit of U3-containing 90S preribosome processome complex involved in small ribosomal subunit assembly; stimulates Bms1p GTPase and U3 binding activity; similar to RNA cyclase-like proteins but no cyclase activity detected.


ensembl_gene_id: YOL011W
symbol: PLB3
gene_biotype: protein_coding
description:
  Phospholipase B (lysophospholipase) involved in lipid metabolism; hydrolyzes phosphatidylinositol and phosphatidylserine and displays transacylase activity in vitro; PLB3 has a paralog, PLB1, that arose from the whole genome duplication.


ensembl_gene_id: YOL012C
symbol: HTZ1
gene_biotype: protein_coding
description:
  Histone variant H2AZ; exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin; Htz1p-containing nucleosomes facilitate RNA Pol II passage by affecting correct assembly and modification status of RNA Pol II elongation complexes and by favoring efficient nucleosome remodeling.


ensembl_gene_id: YOL013C
symbol: HRD1
gene_biotype: protein_coding
description:
  ERAD-associated E3 ubiquitin-protein ligase HRD1; Ubiquitin-protein ligase involved in ER-associated degradation (ERAD) of misfolded proteins; upon autoubiquitination triggers retrotranslocation of misfolded proteins to cytosol for degradation; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger; likely plays a general role in targeting proteins that persistently associate with and potentially obstruct the ER-localized translocon; Belongs to the HRD1 family.


ensembl_gene_id: YOL013W-B
symbol: YOL013W-B
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YOL013W-B; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; completely overlaps the long terminal repeat (LTR) of a Ty1 element.


ensembl_gene_id: YOL015W
symbol: IRC10
gene_biotype: protein_coding
description:
  Uncharacterized protein IRC10; Protein of unknown function; subunit of the leading edge protein (LEP) complex (Ssp1-Ady3-Don1-Irc10) that forms a ring-like structure at the leading edge of the prospore membrane during meiosis II; null mutant displays increased levels of spontaneous Rad52p foci.


ensembl_gene_id: YOL016C
symbol: CMK2
gene_biotype: protein_coding
description:
  Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK2 has a paralog, CMK1, that arose from the whole genome duplication.


ensembl_gene_id: YOL017W
symbol: ESC8
gene_biotype: protein_coding
description:
  Protein involved in telomeric and mating-type locus silencing; interacts with Sir2p and also interacts with Gal11p, which is a component of the RNA pol II mediator complex; ESC8 has a paralog, IOC3, that arose from the whole genome duplication.


ensembl_gene_id: YOL018C
symbol: TLG2
gene_biotype: protein_coding
description:
  t-SNARE affecting a late Golgi compartment protein 2; Syntaxin-like t-SNARE; forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; required along with VPS45 for an early step of the constitutive CVT pathway; interactions with Vps45 prevents Tlg2p degradation, and facilitates t-SNARE complex formation; homologous to mammalian SNARE protein syntaxin 16 (Sx16).


ensembl_gene_id: YOL019W
symbol: YOL019W
gene_biotype: protein_coding
description:
  Uncharacterized membrane protein YOL019W; Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole; YOL019W has a paralog, DCV1, that arose from the whole genome duplication.


ensembl_gene_id: YOL019W-A
symbol: YOL019W-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YOL019W-A; Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching.


ensembl_gene_id: YOL021C
symbol: DIS3
gene_biotype: protein_coding
description:
  Exosome core complex catalytic subunit; has both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; role in degradation of tRNAs; similar to E. coli RNase R and to human DIS3, which partially complements dis3-81 heat sensitivity; mutations in Dis3p analogous to human mutations implicated in multiple myeloma impair exosome function; protein abundance increases under to DNA replication stress.


ensembl_gene_id: YOL022C
symbol: TSR4
gene_biotype: protein_coding
description:
  20S rRNA accumulation protein 4; Cytoplasmic protein required for correct processing of 20S pre-rRNA; protein required for processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; essential gene in S288C background but not in CEN.PK2.


ensembl_gene_id: YOL024W
symbol: YOL024W
gene_biotype: protein_coding
description:
  Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site; YOL024W has a paralog, IGD1, that arose from the whole genome duplication.


ensembl_gene_id: YOL025W
symbol: LAG2
gene_biotype: protein_coding
description:
  Cullin-associated NEDD8-dissociated protein 1 homolog; Protein that negatively regulates the SCF E3-ubiquitin ligase; regulates by interacting with and preventing neddyation of the cullin subunit, Cdc53p; longevity determinant that is preferentially expressed in young cells; similar to mammalian Cand1.


ensembl_gene_id: YOL026C
symbol: MIM1
gene_biotype: protein_coding
description:
  Mitochondrial protein required for outer membrane protein import; cooperates with Tom70p to import the subset of proteins with multiple alpha-helical transmembrane segments, including Ugo1p, Tom20p, and others; present in a complex with Mim2p in the outer membrane that may create a local environment to facilitate membrane insertion of substrate proteins; also has a role in assembly of Tom20p into the TOM complex; Belongs to the MIM1 family.


ensembl_gene_id: YOL027C
symbol: MDM38
gene_biotype: protein_coding
description:
  Mitochondrial distribution and morphology protein 38; Mitochondrial protein; forms a complex with Mba1p to facilitate recruitment of mRNA-specific translational activators to ribosomes; roles in protein export and K+/H+ exchange; human ortholog Letm1 implicated in Wolf-Hirschhorn syndrome.


ensembl_gene_id: YOL028C
symbol: YAP7
gene_biotype: protein_coding
description:
  Putative basic leucine zipper (bZIP) transcription factor; YAP7 has a paralog, YAP5, that arose from the whole genome duplication.


ensembl_gene_id: YOL029C
symbol: YOL029C
gene_biotype: protein_coding
description:
  Uncharacterized protein YOL029C; Putative protein of unknown function; identified as interacting with Hsc82p and Hsp82p in high-throughput two-hybrid screens.


ensembl_gene_id: YOL030W
symbol: GAS5
gene_biotype: protein_coding
description:
  1,3-beta-glucanosyltransferase; has similarity to Gas1p; localizes to the cell wall; Belongs to the glycosyl hydrolase 72 family.


ensembl_gene_id: YOL031C
symbol: SIL1
gene_biotype: protein_coding
description:
  Nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p; required for protein translocation into the endoplasmic reticulum (ER); homolog of Yarrowia lipolytica SLS1; GrpE-like protein; Belongs to the SIL1 family.


ensembl_gene_id: YOL032W
symbol: OPI10
gene_biotype: protein_coding
description:
  Protein with a possible role in phospholipid biosynthesis; null mutant displays an inositol-excreting phenotype that is suppressed by exogenous choline; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YOL033W
symbol: MSE1
gene_biotype: protein_coding
description:
  Glutamate--tRNA ligase, mitochondrial; Mitochondrial glutamyl-tRNA synthetase; predicted to be palmitoylated; Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.


ensembl_gene_id: YOL034W
symbol: SMC5
gene_biotype: protein_coding
description:
  Structural maintenance of chromosomes protein 5; Subunit of the SMC5-SMC6 complex; the SMC5-SMC6 complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; binds single-stranded DNA and has ATPase activity; supports nucleolar function; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair.


ensembl_gene_id: YOL035C
symbol: YOL035C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YOL035C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YOL036W
symbol: YOL036W
gene_biotype: protein_coding
description:
  Uncharacterized protein YOL036W; Protein of unknown function; potential Cdc28p substrate; YOL036W has a paralog, YIR016W, that arose from the whole genome duplication.


ensembl_gene_id: YOL037C
symbol: YOL037C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YOL037C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOL036W.


ensembl_gene_id: YOL038C-A
symbol: YOL038C-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YOL038C-A; Putative protein of unknown function; identified by SAGE analysis.


ensembl_gene_id: YOL038W
symbol: PRE6
gene_biotype: protein_coding
description:
  Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress; Belongs to the peptidase T1A family.


ensembl_gene_id: YOL039W
symbol: RPP2A
gene_biotype: protein_coding
description:
  60S acidic ribosomal protein P2-alpha; Ribosomal protein P2 alpha; a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; free (non-ribosomal) P2 stimulates the phosphorylation of the eIF2 alpha subunit (Sui2p) by Gcn2p; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm.


ensembl_gene_id: YOL040C
symbol: RPS15
gene_biotype: protein_coding
description:
  Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15 and bacterial S19.


ensembl_gene_id: YOL041C
symbol: NOP12
gene_biotype: protein_coding
description:
  Nucleolar protein involved in pre-25S rRNA processing; also involved in biogenesis of large 60S ribosomal subunit; contains an RNA recognition motif (RRM); binds to Ebp2; similar to Nop13p and Nsr1p; Belongs to the RRM RBM34 family.


ensembl_gene_id: YOL042W
symbol: NGL1
gene_biotype: protein_coding
description:
  RNA exonuclease NGL1; Putative endonuclease; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; Belongs to the CCR4/nocturin family.


ensembl_gene_id: YOL043C
symbol: NTG2
gene_biotype: protein_coding
description:
  Endonuclease III homolog 2; DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair, localizes to the nucleus; sumoylated; NTG2 has a paralog, NTG1, that arose from the whole genome duplication.


ensembl_gene_id: YOL044W
symbol: PEX15
gene_biotype: protein_coding
description:
  Tail-anchored type II integral peroxisomal membrane protein; required for peroxisome biogenesis; cells lacking Pex15p mislocalize peroxisomal matrix proteins to cytosol; overexpression results in impaired peroxisome assembly.


ensembl_gene_id: YOL045W
symbol: PSK2
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase PSK2; PAS-domain containing serine/threonine protein kinase; regulates sugar flux and translation in response to an unknown metabolite by phosphorylating Ugp1p and Gsy2p (sugar flux) and Caf20p, Tif11p and Sro9p (translation); PSK2 has a paralog, PSK1, that arose from the whole genome duplication.


ensembl_gene_id: YOL046C
symbol: YOL046C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YOL046C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene PSK2/YOL045W.


ensembl_gene_id: YOL047C
symbol: LDS2
gene_biotype: protein_coding
description:
  Protein Involved in spore wall assembly; localizes to lipid droplets found on or outside of the prospore membrane; shares similarity with Lds1p and Rrt8p, and a strain mutant for all 3 genes exhibits reduced dityrosine fluorescence relative to the single mutants; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern.


ensembl_gene_id: YOL048C
symbol: RRT8
gene_biotype: protein_coding
description:
  Protein involved in spore wall assembly; shares similarity with Lds1p and Lds2p and a strain mutant for all 3 genes exhibits reduced dityrosine fluorescence relative to the single mutants; identified in a screen for mutants with increased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to lipid particles; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YOL049W
symbol: GSH2
gene_biotype: protein_coding
description:
  Glutathione synthetase; catalyzes the ATP-dependent synthesis of glutathione (GSH) from gamma-glutamylcysteine and glycine; induced by oxidative stress and heat shock.


ensembl_gene_id: YOL050C
symbol: YOL050C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YOL050C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO).


ensembl_gene_id: YOL051W
symbol: GAL11
gene_biotype: protein_coding
description:
  Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors; forms part of the tail domain of mediator.


ensembl_gene_id: YOL052C
symbol: SPE2
gene_biotype: protein_coding
description:
  S-adenosylmethionine decarboxylase; required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically; Belongs to the eukaryotic AdoMetDC family.


ensembl_gene_id: YOL052C-A
symbol: DDR2
gene_biotype: protein_coding
description:
  Protein DDR2; Multi-stress response protein; expression is activated by a variety of xenobiotic agents and environmental or physiological stresses; DDR2 has a paralog, HOR7, that arose from the whole genome duplication.


ensembl_gene_id: YOL053W
symbol: AIM39
gene_biotype: protein_coding
description:
  Protein of unknown function; null mutant displays elevated frequency of mitochondrial genome loss; Belongs to the AIM39 family.


ensembl_gene_id: YOL054W
symbol: PSH1
gene_biotype: protein_coding
description:
  RING finger protein PSH1; E3 ubiquitin ligase targeting centromere-binding protein Cse4p; mediates polyubiquitination and degradation of histone H3 variant Cse4p, preventing its mislocalization to euchromatin independent of Slx5p; ubiquitination of Cse4p may be antagonized by Scm3p.


ensembl_gene_id: YOL055C
symbol: THI20
gene_biotype: protein_coding
description:
  Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20; Trifunctional enzyme of thiamine biosynthesis, degradation and salvage; has hydroxymethylpyrimidine (HMP) kinase, HMP-phosphate (HMP-P) kinase and thiaminase activities; member of a gene family with THI21 and THI22; HMP and HMP-P kinase activity redundant with Thi21p; In the C-terminal section; belongs to the thiaminase-2 family.


ensembl_gene_id: YOL056W
symbol: GPM3
gene_biotype: protein_coding
description:
  Homolog of Gpm1p phosphoglycerate mutase; converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional; GPM3 has a paralog, GPM2, that arose from the whole genome duplication; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily.


ensembl_gene_id: YOL057W
symbol: YOL057W
gene_biotype: protein_coding
description:
  Dipeptidyl-peptidase III; cleaves dipeptides from the amino terminus of target proteins; highly active on synthetic substrate Arg-Arg-2-naphthylamide; mammalian ortholog may be a biomarker for some cancers; Belongs to the peptidase M49 family.


ensembl_gene_id: YOL058W
symbol: ARG1
gene_biotype: protein_coding
description:
  Argininosuccinate synthase; Arginosuccinate synthetase; catalyzes the formation of L-argininosuccinate from citrulline and L-aspartate in the arginine biosynthesis pathway; potential Cdc28p substrate.


ensembl_gene_id: YOL059W
symbol: GPD2
gene_biotype: protein_coding
description:
  Glycerol-3-phosphate dehydrogenase [NAD(+)] 2, mitochondrial; NAD-dependent glycerol 3-phosphate dehydrogenase; expression is controlled by an oxygen-independent signaling pathway required to regulate metabolism under anoxic conditions; located in cytosol and mitochondria; constitutively active but is inactivated via phosphorylation by energy-stress responsive kinase SNF1; GPD2 has a paralog, GPD1, that arose from the whole genome duplication.


ensembl_gene_id: YOL061W
symbol: PRS5
gene_biotype: protein_coding
description:
  Ribose-phosphate pyrophosphokinase 5; 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; forms cytoplasmic foci upon DNA replication stress; Belongs to the ribose-phosphate pyrophosphokinase family.


ensembl_gene_id: YOL062C
symbol: APM4
gene_biotype: protein_coding
description:
  Cargo-binding mu subunit of AP-2; AP-2 is a heterotetrameric endocytic cargo-binding adaptor that facilitates uptake of membrane proteins during clathrin-mediated endocytosis; Apm4p is required for AP-2 function and localization, and binds cell wall stress receptor Mid2p; AP-2 is required for cell polarity responses to pheromone, nutritional status and cell wall damage in S. cerevisiae, and for hyphal growth in C. albicans; AP-2 complex is conserved in mammals; Belongs to the adaptor complexes medium subunit family.


ensembl_gene_id: YOL063C
symbol: CRT10
gene_biotype: protein_coding
description:
  Protein involved in transcriptional regulation of RNR2 and RNR3; expression of the gene is induced by DNA damage and null mutations confer increased resistance to hydroxyurea; N-terminal region has a leucine repeat and a WD40 repeat.


ensembl_gene_id: YOL064C
symbol: MET22
gene_biotype: protein_coding
description:
  Bisphosphate-3'-nucleotidase; involved in salt tolerance and methionine biogenesis; dephosphorylates 3'-phosphoadenosine-5'-phosphate and 3'-phosphoadenosine-5'-phosphosulfate, intermediates of the sulfate assimilation pathway; human homolog BPNT1 complements yeast null mutant; Belongs to the inositol monophosphatase superfamily.


ensembl_gene_id: YOL065C
symbol: INP54
gene_biotype: protein_coding
description:
  Phosphatidylinositol 4,5-bisphosphate 5-phosphatase; role in secretion; localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins.


ensembl_gene_id: YOL066C
symbol: RIB2
gene_biotype: protein_coding
description:
  Bifunctional DRAP deaminase tRNA:pseudouridine synthase; the deaminase catalyzes the third step in riboflavin biosynthesis and the synthase catalyzes formation of pseudouridine at position 32 in cytoplasmic tRNAs; RIB2 has a paralog, PUS9, that arose from the whole genome duplication.


ensembl_gene_id: YOL067C
symbol: RTG1
gene_biotype: protein_coding
description:
  Retrograde regulation protein 1; Transcription factor (bHLH) involved in interorganelle communication; contributes to communication between mitochondria, peroxisomes, and nucleus; target of Hog1p; activated in stochastic pulses of nuclear localization.


ensembl_gene_id: YOL068C
symbol: HST1
gene_biotype: protein_coding
description:
  NAD-dependent protein deacetylase HST1; NAD(+)-dependent histone deacetylase; essential subunit of the Sum1p/Rfm1p/Hst1p complex required for ORC-dependent silencing and meiotic repression; non-essential subunit of the Set3C deacetylase complex; involved in telomere maintenance; HST1 has a paralog, SIR2, that arose from the whole genome duplication.


ensembl_gene_id: YOL069W
symbol: NUF2
gene_biotype: protein_coding
description:
  Kinetochore protein NUF2; Component of the kinetochore-associated Ndc80 complex; involved in chromosome segregation, spindle checkpoint activity, and kinetochore clustering; evolutionarily conserved; other members include Ndc80p, Nuf2p, Spc24p, and Spc25p.


ensembl_gene_id: YOL070C
symbol: NBA1
gene_biotype: protein_coding
description:
  Protein of unknown function; localizes to the bud neck and cytoplasm; interacts with Nap1p; may interact with ribosomes, based on co-purification experiments; potential Cdc28p substrate.


ensembl_gene_id: YOL071W
symbol: SDH5
gene_biotype: protein_coding
description:
  Succinate dehydrogenase assembly factor 2, mitochondrial; Protein required for flavinylation of Sdh1p; binds to Sdh1p and promotes FAD cofactor attachment, which is necessary for succinate dehydrogenase (SDH) complex assembly and activity; mutations in human ortholog PGL2 are associated with neuroendocrine tumors (paraganglioma).


ensembl_gene_id: YOL072W
symbol: THP1
gene_biotype: protein_coding
description:
  Nuclear mRNA export protein THP1; Nuclear pore-associated protein; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; contains a PAM domain implicated in protein-protein binding.


ensembl_gene_id: YOL073C
symbol: DSC2
gene_biotype: protein_coding
description:
  Multi-transmembrane subunit of the DSC ubiquitin ligase complex; similar in sequence to rhomboid pseudoproteases Der1p and UBAC2 that function in ERAD; ortholog of fission yeast dsc2.


ensembl_gene_id: YOL075C
symbol: YOL075C
gene_biotype: protein_coding
description:
  Uncharacterized ABC transporter ATP-binding protein/permease YOL075C; Putative ABC transporter; Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.


ensembl_gene_id: YOL076W
symbol: MDM20
gene_biotype: protein_coding
description:
  Non-catalytic subunit of the NatB N-terminal acetyltransferase; NatB catalyzes N-acetylation of proteins with specific N-terminal sequences; involved in mitochondrial inheritance and actin assembly; Belongs to the MDM20/NAA25 family.


ensembl_gene_id: YOL077C
symbol: BRX1
gene_biotype: protein_coding
description:
  Ribosome biogenesis protein BRX1; Nucleolar protein; constituent of 66S pre-ribosomal particles; depletion leads to defects in rRNA processing and a block in the assembly of large ribosomal subunits; possesses a sigma(70)-like RNA-binding motif.


ensembl_gene_id: YOL077W-A
symbol: ATP19
gene_biotype: protein_coding
description:
  Subunit k of the mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; associated only with the dimeric form of ATP synthase; Belongs to the ATP19 family.


ensembl_gene_id: YOL078W
symbol: AVO1
gene_biotype: protein_coding
description:
  Target of rapamycin complex 2 subunit AVO1; Component of a membrane-bound complex containing the Tor2p kinase; contains Tor2p kinase and other proteins; may have a role in regulation of cell growth; Belongs to the SIN1 family.


ensembl_gene_id: YOL079W
symbol: YOL079W
gene_biotype: protein_coding
description:
  Putative uncharacterized membrane protein YOL079W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YOL081W
symbol: IRA2
gene_biotype: protein_coding
description:
  Inhibitory regulator protein IRA2; GTPase-activating protein; negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions; IRA2 has a paralog, IRA1, that arose from the whole genome duplication; defects in human homolog NF1 are associated with neurofibromatosis.


ensembl_gene_id: YOL082W
symbol: ATG19
gene_biotype: protein_coding
description:
  Autophagy-related protein 19; Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; delivers cargo proteins aminopeptidase I (Ape1p) and alpha-mannosidase (Ams1p) to the phagophore assembly site for packaging into Cvt vesicles; interaction with Atg19p during the Cvt pathway requires phosphorylation by Hrr25p.


ensembl_gene_id: YOL083C-A
symbol: YOL083C-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YOL083C-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by expression profiling and mass spectrometry.


ensembl_gene_id: YOL083W
symbol: ATG34
gene_biotype: protein_coding
description:
  Autophagy-related protein 34; Receptor protein involved in selective autophagy during starvation; specifically involved in the transport of cargo protein alpha-mannosidase (Ams1p); Atg19p paralog.


ensembl_gene_id: YOL084W
symbol: PHM7
gene_biotype: protein_coding
description:
  Phosphate metabolism protein 7; Protein of unknown function; expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YOL085C
symbol: YOL085C
gene_biotype: protein_coding
description:
  Uncharacterized protein YOL085C; Putative protein of unknown function; conserved among S. cerevisiae strains; YOL085C is not an essential gene; partially overlaps dubious ORF YOL085W-A.


ensembl_gene_id: YOL085W-A
symbol: YOL085W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YOL085W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YOL085C.


ensembl_gene_id: YOL086C
symbol: ADH1
gene_biotype: protein_coding
description:
  Alcohol dehydrogenase; fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway; ADH1 has a paralog, ADH5, that arose from the whole genome duplication.


ensembl_gene_id: YOL086W-A
symbol: MHF1
gene_biotype: protein_coding
description:
  Inner kinetochore subunit MHF1; Component of the heterotetrameric MHF histone-fold complex; in humans the MHF complex interacts with both DNA and Mph1p ortholog FANCM, a Fanconi anemia complementation group protein, to stabilize and remodel blocked replication forks and repair damaged DNA; mhf1 srs2 double mutants are MMS hypersensitive; ortholog of human centromere constitutive-associated network (CCAN) subunit CENP-S, also known as MHF1.


ensembl_gene_id: YOL087C
symbol: DUF1
gene_biotype: protein_coding
description:
  DUB-associated factor 1; Ubiquitin-binding protein of unknown function; contains one WD40 repeat in a beta-propeller fold; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; homolog of human WDR48/UAF1, which is involved in regulating the Fanconi anemia pathway; deletion mutant is sensitive to various chemicals including phenanthroline, sanguinarine, and nordihydroguaiaretic acid.


ensembl_gene_id: YOL088C
symbol: MPD2
gene_biotype: protein_coding
description:
  Member of the protein disulfide isomerase (PDI) family; exhibits chaperone activity; overexpression suppresses the lethality of a pdi1 deletion but does not complement all Pdi1p functions; undergoes oxidation by Ero1p.


ensembl_gene_id: YOL089C
symbol: HAL9
gene_biotype: protein_coding
description:
  Halotolerance protein 9; Putative transcription factor containing a zinc finger; overexpression increases salt tolerance through increased expression of the ENA1 (Na+/Li+ extrusion pump) gene while gene disruption decreases both salt tolerance and ENA1 expression; HAL9 has a paralog, TBS1, that arose from the whole genome duplication.


ensembl_gene_id: YOL090W
symbol: MSH2
gene_biotype: protein_coding
description:
  Protein that binds to DNA mismatches; forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity and involved in interstrand cross-link repair; Msh2p-Msh6p binds to and hydrolyzes ATP.


ensembl_gene_id: YOL091W
symbol: SPO21
gene_biotype: protein_coding
description:
  Sporulation-specific protein 21; Component of the meiotic outer plaque of the spindle pole body; involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation; SPO21 has a paralog, YSW1, that arose from the whole genome duplication.


ensembl_gene_id: YOL092W
symbol: YPQ1
gene_biotype: protein_coding
description:
  Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter; YPQ1 has a paralog, RTC2, that arose from the whole genome duplication; Belongs to the laat-1 family.


ensembl_gene_id: YOL093W
symbol: TRM10
gene_biotype: protein_coding
description:
  tRNA methyltransferase; methylates the N-1 position of guanine at position 9 in tRNAs; protein abundance increases in response to DNA replication stress; member of the SPOUT (SpoU-TrmD) methyltransferase family; human ortholog TRMT10A plays a role in the pathogenesis of microcephaly and early onset diabetes; an 18-mer originates from the TRM10 locus; genetic analysis shows the 18-mer is the translation regulator; Belongs to the class IV-like SAM-binding methyltransferase superfamily. TRM10 family.


ensembl_gene_id: YOL095C
symbol: HMI1
gene_biotype: protein_coding
description:
  Mitochondrial inner membrane localized ATP-dependent DNA helicase; required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription; has homology to E. coli helicase uvrD.


ensembl_gene_id: YOL096C
symbol: COQ3
gene_biotype: protein_coding
description:
  O-methyltransferase; catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex; phosphoprotein; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.


ensembl_gene_id: YOL097C
symbol: WRS1
gene_biotype: protein_coding
description:
  Tryptophan--tRNA ligase, cytoplasmic; Cytoplasmic tryptophanyl-tRNA synthetase; aminoacylates tryptophanyl-tRNA; human homolog WARS can complement yeast null mutant; Belongs to the class-I aminoacyl-tRNA synthetase family.


ensembl_gene_id: YOL097W-A
symbol: YOL097W-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YOL097W-A; Putative protein of unknown function; identified by expression profiling and mass spectrometry.


ensembl_gene_id: YOL098C
symbol: SDD3
gene_biotype: protein_coding
description:
  Uncharacterized protein YOL098C; Putative metalloprotease; overproduction suppresses lethality due to expression of the dominant PET9 allele AAC2-A128P.


ensembl_gene_id: YOL099C
symbol: YOL099C
gene_biotype: protein_coding
description:
  Putative uncharacterized membrane protein YOL099C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps verified gene PKH2/YOL100W; may interact with ribosomes.


ensembl_gene_id: YOL100W
symbol: PKH2
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase PKH2; Serine/threonine protein kinase; involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; contains a PH-like domain; redundant with Pkh1p; PKH2 has a paralog, PKH1, that arose from the whole genome duplication.


ensembl_gene_id: YOL101C
symbol: IZH4
gene_biotype: protein_coding
description:
  ADIPOR-like receptor IZH4; Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family; expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism; protein increases in abundance and relocalizes from nucleus to ER upon DNA replication stress; IZH4 has a paralog, IZH1, that arose from the whole genome duplication.


ensembl_gene_id: YOL102C
symbol: TPT1
gene_biotype: protein_coding
description:
  tRNA 2'-phosphotransferase that catalyzes final step in tRNA splicing: the transfer of the 2'-PO(4) from the splice junction to NAD(+) to form ADP-ribose 1''-2''cyclic phosphate and nicotinamide.


ensembl_gene_id: YOL103W
symbol: ITR2
gene_biotype: protein_coding
description:
  Myo-inositol transporter; member of the sugar transporter superfamily; expressed constitutively; ITR2 has a paralog, ITR1, that arose from the whole genome duplication; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.


ensembl_gene_id: YOL104C
symbol: NDJ1
gene_biotype: protein_coding
description:
  Non-disjunction protein 1; Protein that regulates meiotic SPB cohesion and telomere clustering; localizes to both spindle pole bodies (SPBs) and telomeres; required for bouquet formation, effective homolog pairing, ordered cross-over distribution, sister chromatid cohesion at meiotic telomeres, chromosomal segregation and telomere-led rapid prophase movement.


ensembl_gene_id: YOL105C
symbol: WSC3
gene_biotype: protein_coding
description:
  Cell wall integrity and stress response component 3; Sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway; involved in maintenance of cell wall integrity; involved in response to heat shock and other stressors; regulates 1,3-beta-glucan synthesis; WSC3 has a paralog, WSC2, that arose from the whole genome duplication.


ensembl_gene_id: YOL106W
symbol: YOL106W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YOL106W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YOL107W
symbol: YOL107W
gene_biotype: protein_coding
description:
  Transmembrane protein 115 homolog; Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and colocalizes in a punctate pattern with the early golgi/COPI vesicles; YOL107W is not an essential protein; Belongs to the TMEM115 family.


ensembl_gene_id: YOL108C
symbol: INO4
gene_biotype: protein_coding
description:
  Protein INO4; Transcription factor involved in phospholipid synthesis; required for derepression of inositol-choline-regulated genes involved in phospholipid synthesis; forms a complex, with Ino2p, that binds the inositol-choline-responsive element through a basic helix-loop-helix domain.


ensembl_gene_id: YOL109W
symbol: ZEO1
gene_biotype: protein_coding
description:
  Protein ZEO1; Peripheral membrane protein of the plasma membrane; interacts with Mid2p; regulates the cell integrity pathway mediated by Pkc1p and Slt2p; the authentic protein is detected in a phosphorylated state in highly purified mitochondria.


ensembl_gene_id: YOL110W
symbol: SHR5
gene_biotype: protein_coding
description:
  Ras modification protein ERF4; Palmitoyltransferase subunit; this complex adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; palmitoylation is required for Ras2p membrane localization; Palmitoyltransferase is composed of Shr5p and Erf2.


ensembl_gene_id: YOL111C
symbol: MDY2
gene_biotype: protein_coding
description:
  Ubiquitin-like protein MDY2; Protein involved in inserting tail-anchored proteins into ER membranes; forms a complex with Get4p; required for efficient mating; involved in shmoo formation and nuclear migration in the pre-zygote; associates with ribosomes.


ensembl_gene_id: YOL112W
symbol: MSB4
gene_biotype: protein_coding
description:
  GTPase-activating protein of the Ras superfamily; acts primarily on Sec4p, localizes to the bud site and bud tip; msb3 msb4 double mutation causes defects in secretion and actin organization; similar to the TBC-domain Tre2 oncogene; MSB4 has a paralog, MSB3, that arose from the whole genome duplication; human homolog USP6NL can complement yeast msb3 msb4 double null mutant.


ensembl_gene_id: YOL113W
symbol: SKM1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase SKM1; Member of the PAK family of serine/threonine protein kinases; similar to Ste20p; involved in down-regulation of sterol uptake; proposed to be a downstream effector of Cdc42p during polarized growth; SKM1 has a paralog, CLA4, that arose from the whole genome duplication.


ensembl_gene_id: YOL114C
symbol: PTH4
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YOL114C; Protein similar to the human peptidyl-tRNA hydrolase gene ICT1; associates with mitochondrial large subunit; may function in translation termination; YOL114C is not an essential gene.


ensembl_gene_id: YOL115W
symbol: PAP2
gene_biotype: protein_coding
description:
  Non-canonical poly(A) polymerase; involved in nuclear RNA degradation as a component of TRAMP; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; required for mRNA surveillance and maintenance of genome integrity, serving as a link between RNA and DNA metabolism; overlapping but non-redundant functions with Trf5p; relocalizes to cytosol in response to hypoxia.


ensembl_gene_id: YOL116W
symbol: MSN1
gene_biotype: protein_coding
description:
  Protein MSN1; Transcriptional activator; involved in regulation of invertase and glucoamylase expression, invasive growth and pseudohyphal differentiation, iron uptake, chromium accumulation, and response to osmotic stress; localizes to the nucleus; relative distribution to the nucleus increases upon DNA replication stress.


ensembl_gene_id: YOL117W
symbol: RRI2
gene_biotype: protein_coding
description:
  Subunit of the COP9 signalosome (CSN) complex; this complex cleaves the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; plays a role in the mating pheromone response.


ensembl_gene_id: YOL118C
symbol: YOL118C
gene_biotype: protein_coding
description:
  Uncharacterized protein YOL118C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YOL119C
symbol: MCH4
gene_biotype: protein_coding
description:
  Probable transporter MCH4; Protein with similarity to mammalian monocarboxylate permeases; monocarboxylate permeases are involved in transport of monocarboxylic acids across the plasma membrane but mutant is not deficient in monocarboxylate transport; Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.


ensembl_gene_id: YOL120C
symbol: RPL18A
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L18A; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18A has a paralog, RPL18B, that arose from the whole genome duplication.


ensembl_gene_id: YOL121C
symbol: RPS19A
gene_biotype: protein_coding
description:
  Protein component of the small (40S) ribosomal subunit; required for assembly and maturation of pre-40 S particles; homologous to mammalian ribosomal protein S19, no bacterial homolog; mutations in human RPS19 are associated with Diamond Blackfan anemia; RPS19A has a paralog, RPS19B, that arose from the whole genome duplication.


ensembl_gene_id: YOL122C
symbol: SMF1
gene_biotype: protein_coding
description:
  Manganese transporter SMF1; Divalent metal ion transporter; broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins; Belongs to the NRAMP family.


ensembl_gene_id: YOL123W
symbol: HRP1
gene_biotype: protein_coding
description:
  Nuclear polyadenylated RNA-binding protein 4; Subunit of cleavage factor I; cleavage factor I is a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences; required for genome stability.


ensembl_gene_id: YOL124C
symbol: TRM11
gene_biotype: protein_coding
description:
  Catalytic subunit of adoMet-dependent tRNA methyltransferase complex; required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain; another complex member is Trm112p; Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM11 methyltransferase family.


ensembl_gene_id: YOL125W
symbol: TRM13
gene_biotype: protein_coding
description:
  tRNA:m(4)X modification enzyme TRM13; 2'-O-methyltransferase; responsible for modification of tRNA at position 4; C-terminal domain has similarity to Rossmann-fold (RFM) superfamily of RNA methyltransferases; Belongs to the methyltransferase TRM13 family.


ensembl_gene_id: YOL126C
symbol: MDH2
gene_biotype: protein_coding
description:
  Cytoplasmic malate dehydrogenase; one of three isozymes that catalyze interconversion of malate and oxaloacetate; involved in the glyoxylate cycle and gluconeogenesis during growth on two-carbon compounds; interacts with Pck1p and Fbp1.


ensembl_gene_id: YOL127W
symbol: RPL25
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L25; primary rRNA-binding ribosomal protein component of large ribosomal subunit; binds to 25S rRNA via a conserved C-terminal motif; homologous to mammalian ribosomal protein L23A and bacterial L23; Belongs to the universal ribosomal protein uL23 family.


ensembl_gene_id: YOL128C
symbol: YGK3
gene_biotype: protein_coding
description:
  Glycogen synthase kinase-3 homolog YGK3; Protein kinase related to mammalian GSK-3 glycogen synthase kinases; GSK-3 homologs (Mck1p, Rim11p, Mrk1p, Ygk3p) are involved in control of Msn2p-dependent transcription of stress responsive genes and in protein degradation; YGK3 has a paralog, MCK1, that arose from the whole genome duplication.


ensembl_gene_id: YOL129W
symbol: VPS68
gene_biotype: protein_coding
description:
  Vacuolar membrane protein of unknown function; involved in vacuolar protein sorting; also detected in the mitochondria; Belongs to the UPF0220 family.


ensembl_gene_id: YOL130W
symbol: ALR1
gene_biotype: protein_coding
description:
  Magnesium transporter ALR1; Plasma membrane Mg(2+) transporter; expression and turnover are regulated by Mg(2+) concentration; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions; magnesium transport defect of the null mutant is functionally complemented by either of the human genes MAGT1 and TUSC3 that are not orthologous to ALR1; Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.


ensembl_gene_id: YOL131W
symbol: YOL131W
gene_biotype: protein_coding
description:
  Putative protein of unknown function; YOL131W has a paralog, STB1, that arose from the whole genome duplication.


ensembl_gene_id: YOL132W
symbol: GAS4
gene_biotype: protein_coding
description:
  1,3-beta-glucanosyltransferase; involved with Gas2p in spore wall assembly; has similarity to Gas1p; localizes to the cell wall.


ensembl_gene_id: YOL133W
symbol: HRT1
gene_biotype: protein_coding
description:
  RING-box protein HRT1; RING-H2 domain core subunit of multiple ubiquitin ligase complexes; subunit of Skp1-Cullin-F-box (SCF) that tethers the Cdc34p (E2) and Cdc53p (cullin) SCF subunits, and is required for degradation of Gic2p, Far1p, Sic1p and Cln2p; subunit of the Rtt101p-Mms1p-Mms22p ubiquitin ligase that stabilizes replication forks after DNA lesions; subunit of the Cul3p-Elc1p-Ela1p ubiquitin ligase involved in Rpb1p degradation as part of transcription-coupled repair; Belongs to the RING-box family.


ensembl_gene_id: YOL134C
symbol: YOL134C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YOL134C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps HRT1, a verified gene that encodes an SCF ubiquitin ligase subunit.


ensembl_gene_id: YOL136C
symbol: PFK27
gene_biotype: protein_coding
description:
  6-phosphofructo-2-kinase; catalyzes synthesis of fructose-2,6-bisphosphate; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, expression induced by glucose and sucrose, transcriptional regulation involves protein kinase A.


ensembl_gene_id: YOL137W
symbol: BSC6
gene_biotype: protein_coding
description:
  Bypass of stop codon protein 6; Protein of unknown function with 8 putative transmembrane segments; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression.


ensembl_gene_id: YOL138C
symbol: RTC1
gene_biotype: protein_coding
description:
  Restriction of telomere capping protein 1; Subunit of SEACAT, a subcomplex of the SEA complex; Rtc1p, along with Mtc5p and Sea4p, redundantly inhibit the TORC1 inhibitory role of the Iml1p/SEACIT (Iml1p-Npr2p-Npr3p) subcomplex, a GAP for GTPase Gtr1p (EGOC subunit) in response to amino acid limitation, thereby resulting in activation of TORC1 signaling; SEA is a coatomer-related complex that associates dynamically with the vacuole; has N-terminal WD-40 repeats and a C-terminal RING motif; null suppresses cdc13-1.


ensembl_gene_id: YOL139C
symbol: CDC33
gene_biotype: protein_coding
description:
  mRNA cap binding protein and translation initiation factor eIF4E; the eIF4E-cap complex is responsible for mediating cap-dependent mRNA translation via interactions with translation initiation factor eIF4G (Tif4631p or Tif4632p); protein abundance increases in response to DNA replication stress; mutants are defective for adhesion and pseudohyphal growth; human homolog EIF4E can complement yeast cdc33 null mutant.


ensembl_gene_id: YOL140W
symbol: ARG8
gene_biotype: protein_coding
description:
  Acetylornithine aminotransferase, mitochondrial; Acetylornithine aminotransferase; catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.


ensembl_gene_id: YOL141W
symbol: PPM2
gene_biotype: protein_coding
description:
  tRNA wybutosine-synthesizing protein 4; AdoMet-dependent tRNA methyltransferase; also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p.


ensembl_gene_id: YOL142W
symbol: RRP40
gene_biotype: protein_coding
description:
  Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain both S1 and KH RNA binding domains; mutations in the human homolog, EXOSC3, cause pontocerebellar hypoplasia with motor neuron degeneration.


ensembl_gene_id: YOL143C
symbol: RIB4
gene_biotype: protein_coding
description:
  Lumazine synthase (DMRL synthase); catalyzes synthesis of immediate precursor to riboflavin; DMRL synthase stands for 6,7-dimethyl-8-ribityllumazine synthase.


ensembl_gene_id: YOL145C
symbol: CTR9
gene_biotype: protein_coding
description:
  RNA polymerase-associated protein CTR9; Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cyclin genes; involved in SER3 repression by helping to maintain SRG1 transcription-dependent nucleosome occupancy; contains TPR repeats.


ensembl_gene_id: YOL147C
symbol: PEX11
gene_biotype: protein_coding
description:
  Peroxisomal protein required for medium-chain fatty acid oxidation; also required for peroxisome proliferation, possibly by inducing membrane curvature; localization regulated by phosphorylation; transcription regulated by Adr1p and Pip2p-Oaf1p; Belongs to the peroxin-11 family.


ensembl_gene_id: YOL148C
symbol: SPT20
gene_biotype: protein_coding
description:
  Transcription factor SPT20; Subunit of the SAGA transcriptional regulatory complex; involved in maintaining the integrity of the complex; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay.


ensembl_gene_id: YOL149W
symbol: DCP1
gene_biotype: protein_coding
description:
  Subunit of the Dcp1p-Dcp2p decapping enzyme complex; decapping complex removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p; forms cytoplasmic foci upon DNA replication stress.


ensembl_gene_id: YOL150C
symbol: YOL150C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YOL150C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YOL151W
symbol: GRE2
gene_biotype: protein_coding
description:
  3-methylbutanal reductase and NADPH-dependent methylglyoxal reductase; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway; restores resistance to glycolaldehyde by coupling reduction of glycolaldehyde to ethylene glycol and oxidation of NADPH to NADP+; protein abundance increases in response to DNA replication stress; methylglyoxal reductase (NADPH-dependent) is also known as D-lactaldehyde dehydrogenase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.


ensembl_gene_id: YOL152W
symbol: FRE7
gene_biotype: protein_coding
description:
  Ferric/cupric reductase transmembrane component 7; Putative ferric reductase with similarity to Fre2p; expression induced by low copper levels.


ensembl_gene_id: YOL154W
symbol: ZPS1
gene_biotype: protein_coding
description:
  Protein ZPS1; Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH; Belongs to the ZPS1 family.


ensembl_gene_id: YOL155W-A
symbol: YOL155W-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YOL155W-A; Putative protein of unknown function; identified by expression profiling and mass spectrometry.


ensembl_gene_id: YOL156W
symbol: HXT11
gene_biotype: protein_coding
description:
  Hexose transporter; capable of transporting a broad range of substrates including: glucose, fructose, mannose and galactose; polyol transporter that supports the growth on and uptake of xylitol with low affinity when overexpressed in a strain deleted for hexose family members; nearly identical in sequence to Hxt9p; has similarity to major facilitator superfamily (MFS) transporters; involved in pleiotropic drug resistance; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.


ensembl_gene_id: YOL157C
symbol: IMA2
gene_biotype: protein_coding
description:
  Oligo-1,6-glucosidase IMA2; Isomaltase (alpha-1,6-glucosidase/alpha-methylglucosidase); preferred specificity for isomaltose, alpha-methylglucoside, and palatinose, but also exhibits alpha-1,2 glucosidase activity on sucrose and kojibiose, and can cleave the 1,3-alpha linkage of nigerose and turanose and the alpha-1,5 linkage of leucrose in vitro; not required for isomaltose utilization, but Ima2p overexpression allows the ima1 null mutant to grow on isomaltose.


ensembl_gene_id: YOL158C
symbol: ENB1
gene_biotype: protein_coding
description:
  Siderophore iron transporter ENB1; Endosomal ferric enterobactin transporter; expressed under conditions of iron deprivation; member of the major facilitator superfamily; expression is regulated by Rcs1p and affected by chloroquine treatment.


ensembl_gene_id: YOL159C
symbol: CSS3
gene_biotype: protein_coding
description:
  Protein of unknown function, secreted when constitutively expressed; SWAT-GFP, seamless-GFP and mCherry fusion proteins localize to the cell periphery, SWAT-GFP fusion also localizes to the extracellular region, and mCherry fusion also localizes to the vacuole; deletion mutants are viable and have elevated levels of Ty1 retrotransposition and Ty1 cDNA.


ensembl_gene_id: YOL159C-A
symbol: YOL159C-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YOL159C-A; Protein of unknown function; overexpression affects endocytic protein trafficking; identified by sequence comparison with hemiascomycetous yeast species.


ensembl_gene_id: YOL160W
symbol: YOL160W
gene_biotype: protein_coding
description:
  Uncharacterized protein YOL160W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YOL161C
symbol: PAU20
gene_biotype: protein_coding
description:
  Seripauperin-20; Protein of unknown function; member of the seripauperin multigene family encoded mainly in subtelomeric regions; SWAT-GFP and mCherry fusion proteins localize to the vacuole; expression induced by low temperature and also by anaerobic conditions; induced during alcoholic fermentation.


ensembl_gene_id: YOL162W
symbol: YOL162W
gene_biotype: protein_coding
description:
  Putative uncharacterized transporter YOL162W; Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family.


ensembl_gene_id: YOL163W
symbol: YOL163W
gene_biotype: protein_coding
description:
  Putative uncharacterized transporter YOL163W; Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family.


ensembl_gene_id: YOL164W
symbol: BDS1
gene_biotype: protein_coding
description:
  Alkyl/aryl-sulfatase BDS1; Bacterially-derived sulfatase; required for use of alkyl- and aryl-sulfates as sulfur sources; Belongs to the metallo-beta-lactamase superfamily.


ensembl_gene_id: YOL164W-A
symbol: YOL164W-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YOL164W-A; Putative protein of unknown function; identified by fungal homology and RT-PCR.


ensembl_gene_id: YOL165C
symbol: AAD15
gene_biotype: protein_coding
description:
  Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role; AAD15 has a paralog, AAD3, that arose from a segmental duplication; members of the AAD gene family comprise three pairs (AAD3 + AAD15, AAD6/AAD16 + AAD4, AAD10 + AAD14) whose two genes are more related to one another than to other members of the family.


ensembl_gene_id: YOL166C
symbol: YOL166C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YOL166C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YOL166W-A
symbol: YOL166W-A
gene_biotype: protein_coding
description:
  UPF0320 protein YOL166W-A; Protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; Belongs to the UPF0320 family.


ensembl_gene_id: YOR001W
symbol: RRP6
gene_biotype: protein_coding
description:
  Nuclear exosome exonuclease component; has 3'-5' exonuclease activity that is regulated by Lrp1p; involved in RNA processing, maturation, surveillance, degradation, tethering, and export; role in sn/snoRNAs precursor degradation; forms a stable heterodimer with Lrp1p; has similarity to E. coli RNase D and to human PM-Sc1 100 (EXOSC10); mutant displays reduced transcription elongation in the G-less-based.


ensembl_gene_id: YOR002W
symbol: ALG6
gene_biotype: protein_coding
description:
  Alpha 1,3 glucosyltransferase; involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; C998T transition in human ortholog ALG6 causes carbohydrate-deficient glycoprotein syndrome type-Ic; wild-type human ortholog ALG6 can partially complement yeast alg6 mutant; Belongs to the ALG6/ALG8 glucosyltransferase family.


ensembl_gene_id: YOR003W
symbol: YSP3
gene_biotype: protein_coding
description:
  Putative precursor of the subtilisin-like protease III; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum; YSP3 has a paralog, PRB1, that arose from the whole genome duplication; Belongs to the peptidase S8 family.


ensembl_gene_id: YOR004W
symbol: UTP23
gene_biotype: protein_coding
description:
  rRNA-processing protein UTP23; Component of the small subunit processome; involved in 40S ribosomal subunit biogenesis; interacts with snR30 and is required for dissociation of snR30 from large pre-ribosomal particles; has homology to PINc domain protein Fcf1p, although the PINc domain of Utp23p is not required for function; essential protein.


ensembl_gene_id: YOR005C
symbol: DNL4
gene_biotype: protein_coding
description:
  DNA ligase required for nonhomologous end-joining (NHEJ); forms stable heterodimer with required cofactor Lif1p, interacts with Nej1p; involved in meiosis, not essential for vegetative growth; mutations in human ortholog lead to ligase IV syndrome and Dubowitz syndrome; Belongs to the ATP-dependent DNA ligase family.


ensembl_gene_id: YOR006C
symbol: TSR3
gene_biotype: protein_coding
description:
  Ribosome biogenesis protein TSR3; Protein required for 20S pre-rRNA processing; involved in processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress.


ensembl_gene_id: YOR007C
symbol: SGT2
gene_biotype: protein_coding
description:
  Small glutamine-rich tetratricopeptide repeat-containing protein 2; Glutamine-rich cytoplasmic cochaperone; serves as a scaffold bringing together Get4, Get5p, and other TRC complex members that are required to mediate posttranslational insertion of tail-anchored proteins into the ER membrane; interacts with the prion domain of Sup35p; amyloid sensor; plays a role in targeting chaperones to prion aggregates; similar to human cochaperone SGT; forms cytoplasmic foci upon DNA replication stress.


ensembl_gene_id: YOR008C
symbol: SLG1
gene_biotype: protein_coding
description:
  Protein SLG1; Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway; involved in maintenance of cell wall integrity; required for mitophagy; involved in organization of the actin cytoskeleton; secretory pathway Wsc1p is required for the arrest of secretion response.


ensembl_gene_id: YOR008C-A
symbol: YOR008C-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YOR008C-A; Putative protein of unknown function; includes a potential transmembrane domain; deletion results in slightly lengthened telomeres; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively.


ensembl_gene_id: YOR008W-B
symbol: YOR008W-B
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YOR008W-B; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YOR009W
symbol: TIR4
gene_biotype: protein_coding
description:
  Cell wall mannoprotein; expressed under anaerobic conditions and required for anaerobic growth; transcription is also induced by cold shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins.


ensembl_gene_id: YOR010C
symbol: TIR2
gene_biotype: protein_coding
description:
  Cold shock-induced protein TIR2; Putative cell wall mannoprotein; member of the Srp1p/Tip1p family of serine-alanine-rich proteins; transcription is induced by cold shock and anaerobiosis; TIR2 has a paralog, TIR3, that arose from the whole genome duplication.


ensembl_gene_id: YOR011W
symbol: AUS1
gene_biotype: protein_coding
description:
  ATP-dependent permease AUS1; Plasma membrane sterol transporter of the ATP-binding cassette family; required, along with Pdr11p, for uptake of exogenous sterols and their incorporation into the plasma membrane; activity is stimulated by phosphatidylserine; sterol uptake is required for anaerobic growth because sterol biosynthesis requires oxygen; AUS1 has a paralog, PDR11, that arose from the whole genome duplication; Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.


ensembl_gene_id: YOR013W
symbol: IRC11
gene_biotype: protein_coding
description:
  Putative increased recombination centers protein 11; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YOR012C; null mutant displays increased levels of spontaneous Rad52 foci.


ensembl_gene_id: YOR014W
symbol: RTS1
gene_biotype: protein_coding
description:
  Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform; B-type regulatory subunit of protein phosphatase 2A (PP2A); Rts1p and Cdc55p are alternative regulatory subunits for PP2A catalytic subunits, Pph21p and Pph22p; PP2A-Rts1p protects cohesin when recruited by Sgo1p to the pericentromere; highly enriched at centromeres in the absence of Cdc55p; required for maintenance of septin ring organization during cytokinesis, for ring disassembly in G1 and for dephosphorylation of septin, Shs1p; homolog of the mammalian B' subunit of PP2A.


ensembl_gene_id: YOR015W
symbol: YOR015W
gene_biotype: protein_coding
description:
  Uncharacterized protein YOR015W; Putative protein of unknown function; conserved among S. cerevisiae strains; YOR015W is not an essential gene.


ensembl_gene_id: YOR016C
symbol: ERP4
gene_biotype: protein_coding
description:
  Protein ERP4; Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; ERP4 has a paralog, ERP2, that arose from the whole genome duplication; Belongs to the EMP24/GP25L family.


ensembl_gene_id: YOR017W
symbol: PET127
gene_biotype: protein_coding
description:
  Putative mitochondrial translation system component PET127; Protein with a role in 5'-end processing of mitochondrial RNAs; located in the mitochondrial membrane.


ensembl_gene_id: YOR018W
symbol: ROD1
gene_biotype: protein_coding
description:
  Protein ROD1; Alpha-arrestin involved in ubiquitin-dependent endocytosis; activating dephosphorylation relays glucose signaling to transporter endocytosis; calcineurin dephosphorylation is required for Rsp5p-dependent internalization of agonist-occupied Ste2p, as part of signal desensitization; recruits Rsp5p to Ste2p via its 2 PPXY motifs; protein abundance increases in response to DNA replication stress; ROD1 has a paralog, ROG3, that arose from the whole genome duplication.


ensembl_gene_id: YOR019W
symbol: YOR019W
gene_biotype: protein_coding
description:
  Uncharacterized protein YOR019W; Protein of unknown function; may interact with ribosomes, based on co-purification experiments; YOR019W has a paralog, JIP4, that arose from the whole genome duplication.


ensembl_gene_id: YOR020C
symbol: HSP10
gene_biotype: protein_coding
description:
  10 kDa heat shock protein, mitochondrial; Mitochondrial matrix co-chaperonin; inhibits the ATPase activity of Hsp60p, a mitochondrial chaperonin; involved in protein folding and sorting in the mitochondria; 10 kD heat shock protein with similarity to E. coli groES.


ensembl_gene_id: YOR020W-A
symbol: YOR020W-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YOR020W-A; Putative protein of unknown function; conserved in A. gossypii; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies.


ensembl_gene_id: YOR021C
symbol: SFM1
gene_biotype: protein_coding
description:
  Protein arginine N-methyltransferase SFM1; SPOUT methyltransferase; catalyzes omega-monomethylation of Rps3p on Arg-146; not an essential gene; predicted to be involved in rRNA processing and ribosome biogenesis and in biopolymer catabolism.


ensembl_gene_id: YOR022C
symbol: DDL1
gene_biotype: protein_coding
description:
  DDHD domain-containing phospholipase A1; mitochondrial matrix enzyme with sn-1-specific activity, hydrolyzing cardiolipin, PE, PC, PG and PA; implicated in remodeling of mitochondrial phospholipids; antagonistically regulated by Aft1p and Aft2p; in humans, mutations in DDHD1 and DDHD2 genes cause specific types of hereditary spastic paraplegia, while DDL1-defective yeast share similar phenotypes such as mitochondrial dysfunction and defects in lipid metabolism.


ensembl_gene_id: YOR023C
symbol: AHC1
gene_biotype: protein_coding
description:
  Protein AHC1; Subunit of the Ada histone acetyltransferase complex; required for structural integrity of the complex; Ahc2p and Ahc1p are unique to the ADA complex and not shared with the related SAGA and SLIK complexes; Ahc2p may tether Ahc1p to the complex.


ensembl_gene_id: YOR024W
symbol: YOR024W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YOR024W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YOR025W
symbol: HST3
gene_biotype: protein_coding
description:
  NAD-dependent histone deacetylase HST3; Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism.


ensembl_gene_id: YOR026W
symbol: BUB3
gene_biotype: protein_coding
description:
  Cell cycle arrest protein BUB3; Kinetochore checkpoint WD40 repeat protein; localizes to kinetochores during prophase and metaphase, delays anaphase in the presence of unattached kinetochores; forms complexes with Mad1p-Bub1p and with Cdc20p, binds Mad2p and Mad3p; functions at kinetochore to activate APC/C-Cdc20p for normal mitotic progression.


ensembl_gene_id: YOR027W
symbol: STI1
gene_biotype: protein_coding
description:
  Heat shock protein STI1; Hsp90 cochaperone; regulates spatial organization of amyloid-like proteins in the cytosol, thereby buffering the proteotoxicity caused by amyloid-like proteins; interacts with the Ssa group of the cytosolic Hsp70 chaperones and activates Ssa1p ATPase activity; interacts with Hsp90 chaperones and inhibits their ATPase activity; homolog of mammalian Hop.


ensembl_gene_id: YOR028C
symbol: CIN5
gene_biotype: protein_coding
description:
  Basic leucine zipper (bZIP) transcription factor of the yAP-1 family; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; mediates pleiotropic drug resistance and salt tolerance; nuclearly localized under oxidative stress and sequestered in the cytoplasm by Lot6p under reducing conditions; CIN5 has a paralog, YAP6, that arose from the whole genome duplication.


ensembl_gene_id: YOR029W
symbol: YOR029W
gene_biotype: protein_coding
description:
  Uncharacterized protein YOR029W; Putative protein of unknown function; conserved among S. cerevisiae strains; YOR029W is not an essential gene.


ensembl_gene_id: YOR030W
symbol: DFG16
gene_biotype: protein_coding
description:
  Protein DFG16; Probable multiple transmembrane protein; involved in diploid invasive and pseudohyphal growth upon nitrogen starvation; is glycosylated and phosphorylated; interacts with Rim21p and Rim9p in the plasma membrane to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; required for accumulation of processed Rim101p.


ensembl_gene_id: YOR032C
symbol: HMS1
gene_biotype: protein_coding
description:
  bHLH protein with similarity to myc-family transcription factors; overexpression confers hyperfilamentous growth and suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant.


ensembl_gene_id: YOR032W-A
symbol: YOR032W-A
gene_biotype: protein_coding
description:
  Uncharacterized protein YOR032W-A; Protein of unknown function; SWAT-GFP and seamless-GFP fusion proteins localize to the endoplasmic reticulum; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching.


ensembl_gene_id: YOR033C
symbol: EXO1
gene_biotype: protein_coding
description:
  Exodeoxyribonuclease 1; 5'-3' exonuclease and flap-endonuclease; involved in recombination, double-strand break repair, MMS2 error-free branch of the post replication (PRR) pathway and DNA mismatch repair; role in telomere maintenance; member of the Rad2p nuclease family, with conserved N and I nuclease domains; relative distribution to the nucleus increases upon DNA replication stress; EXO1 has a paralog, DIN7, that arose from the whole genome duplication.


ensembl_gene_id: YOR034C
symbol: AKR2
gene_biotype: protein_coding
description:
  Probable palmitoyltransferase AKR2; Ankyrin repeat-containing protein; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; possibly involved in constitutive endocytosis of Ste3p; AKR2 has a paralog, AKR1, that arose from the whole genome duplication.


ensembl_gene_id: YOR034C-A
symbol: YOR034C-A
gene_biotype: protein_coding
description:
  Uncharacterized membrane protein YOR034C-A; Putative protein of unknown function; identified by expression profiling and mass spectrometry.


ensembl_gene_id: YOR035C
symbol: SHE4
gene_biotype: protein_coding
description:
  SWI5-dependent HO expression protein 4; Protein containing a UCS (UNC-45/CRO1/SHE4) domain; binds to myosin motor domains to regulate myosin function; involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization.


ensembl_gene_id: YOR036W
symbol: PEP12
gene_biotype: protein_coding
description:
  Syntaxin PEP12; Target membrane receptor (t-SNARE); for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin.


ensembl_gene_id: YOR037W
symbol: CYC2
gene_biotype: protein_coding
description:
  Mitochondrial peripheral inner membrane protein; contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p).


ensembl_gene_id: YOR038C
symbol: HIR2
gene_biotype: protein_coding
description:
  Protein HIR2; Subunit of HIR nucleosome assembly complex; involved in regulation of histone gene transcription; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene silencing with Asf1p; relocalizes to the cytosol in response to hypoxia.


ensembl_gene_id: YOR039W
symbol: CKB2
gene_biotype: protein_coding
description:
  Beta' regulatory subunit of casein kinase 2 (CK2); a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase.


ensembl_gene_id: YOR040W
symbol: GLO4
gene_biotype: protein_coding
description:
  Hydroxyacylglutathione hydrolase, mitochondrial; Mitochondrial glyoxalase II; catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate; GLO4 has a paralog, GLO2, that arose from the whole genome duplication.


ensembl_gene_id: YOR041C
symbol: YOR041C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YOR041C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the uncharacterized gene CUE5; deletion in cyr1 mutant results in loss of stress resistance.


ensembl_gene_id: YOR042W
symbol: CUE5
gene_biotype: protein_coding
description:
  Ubiquitin-binding protein; functions as ubiquitin-Atg8p adaptor in ubiquitin-dependent autophagy; serves as proteaphagy receptor for inactivated 26S proteasomes; contains CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; CUE5 has a paralog, DON1, that arose from the whole genome duplication; human TOLLIP is a functional CUE-domain homolog, can complement yeast null mutant, rescuing hypersensitivity of cue5 null mutant cells to Htt-96Q.


ensembl_gene_id: YOR043W
symbol: WHI2
gene_biotype: protein_coding
description:
  Growth regulation protein; Protein required for full activation of the general stress response; required with binding partner Psr1p, possibly through Msn2p dephosphorylation; regulates growth during the diauxic shift; negative regulator of G1 cyclin expression; SWAT-GFP, seamless-GFP and mCherry fusion proteins localize to the cell periphery.


ensembl_gene_id: YOR044W
symbol: IRC23
gene_biotype: protein_coding
description:
  Increased recombination centers protein 23; Protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; null mutant displays increased levels of spontaneous Rad52p foci; IRC23 has a paralog, BSC2, that arose from the whole genome duplication.


ensembl_gene_id: YOR045W
symbol: TOM6
gene_biotype: protein_coding
description:
  Mitochondrial import receptor subunit TOM6; Component of the TOM (translocase of outer membrane) complex; responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex.


ensembl_gene_id: YOR046C
symbol: DBP5
gene_biotype: protein_coding
description:
  Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family; involved in mRNA export from the nucleus, remodeling messenger ribonucleoprotein particles (mRNPs), with ATPase activity stimulated by Gle1p, IP6 and Nup159p; involved in translation termination along with Sup45p (eRF1); role in the cellular response to heat stress.


ensembl_gene_id: YOR047C
symbol: STD1
gene_biotype: protein_coding
description:
  Protein involved in control of glucose-regulated gene expression; interacts with kinase Snf1p, glucose sensors Snf3p and Rgt2p, TATA-binding Spt15p; regulator of transcription factor Rgt1p; interactions with Pma1p appear to propagate [GAR+]; STD1 has a paralog, MTH1, that arose from the whole genome duplication; To yeast MTH1.


ensembl_gene_id: YOR048C
symbol: RAT1
gene_biotype: protein_coding
description:
  5'-3' exoribonuclease 2; Nuclear 5' to 3' single-stranded RNA exonuclease; involved in RNA metabolism, including rRNA and snoRNA processing, as well as poly (A+) dependent and independent mRNA transcription termination; required for cotranscriptional pre-rRNA cleavage; displaces Cdk1p from elongating transcripts, especially as RNAPII reaches the poly(A) site, negatively regulates phosphorylation of the CTD of RNAPII, and inhibits RNAPII transcriptional elongation; Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.


ensembl_gene_id: YOR049C
symbol: RSB1
gene_biotype: protein_coding
description:
  Putative sphingoid long-chain base (LCB) efflux transporter; integral membrane transporter that localizes to the plasma membrane and may transport long chain bases (LCBs) from the cytoplasmic side toward the extracytoplasmic side of the membrane; role in glycerophospholipid translocation; suppressor of the sphingoid LCB sensitivity of an LCB-lyase mutation.


ensembl_gene_id: YOR050C
symbol: YOR050C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YOR050C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; null mutant is viable.


ensembl_gene_id: YOR051C
symbol: ETT1
gene_biotype: protein_coding
description:
  Enhancer of translation termination 1; Nuclear protein that inhibits replication of Brome mosaic virus; S. cerevisiae is a model system for studying replication of positive-strand RNA viruses in their natural hosts; deletion increases stop codon readthrough; Belongs to the ETT1 family.


ensembl_gene_id: YOR052C
symbol: TMC1
gene_biotype: protein_coding
description:
  AN1-type zinc finger protein, effector of proteotoxic stress response; stress-inducible transcriptional target of Rpn4p; induced by nitrogen limitation, weak acid, misfolded proteins; short-lived protein, degraded by proteasome; may protect cells from trivalent metalloid induced proteotoxicity; contains PACE promoter element; ortholog of human AIRAP, which stimulates proteasome activity in response to arsenic; protein abundance increases under DNA replication stress.


ensembl_gene_id: YOR053W
symbol: YOR053W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YOR053W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VHS3/YOR054C.


ensembl_gene_id: YOR054C
symbol: VHS3
gene_biotype: protein_coding
description:
  Phosphopantothenoylcysteine decarboxylase subunit VHS3; Negative regulatory subunit of protein phosphatase 1 Ppz1p; involved in coenzyme A biosynthesis; subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex and the CoA-Synthesizing Protein Complex (CoA-SPC: Cab2p, Cab3p, Cab4p, Cab5p, Sis2p and Vhs3p).


ensembl_gene_id: YOR055W
symbol: YOR055W
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YOR055W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data.


ensembl_gene_id: YOR056C
symbol: NOB1
gene_biotype: protein_coding
description:
  20S-pre-rRNA D-site endonuclease NOB1; Protein involved in proteasomal and 40S ribosomal subunit biogenesis; required for cleavage of the 20S pre-rRNA to generate the mature 18S rRNA; cleavage is activated by Fun12p, a GTPase and translation initiation factor; relocalizes from nucleus to nucleolus upon DNA replication stress; Belongs to the NOB1 family.


ensembl_gene_id: YOR057W
symbol: SGT1
gene_biotype: protein_coding
description:
  Cochaperone protein; regulates activity of adenylyl cyclase Cyr1p; involved in kinetochore complex assembly; associates with the SCF (Skp1p/Cdc53p/F box protein) ubiquitin ligase complex; acts as a linker between Skp1p and HSP90 complexes; protein abundance increases in response to DNA replication stress; Belongs to the SGT1 family.


ensembl_gene_id: YOR058C
symbol: ASE1
gene_biotype: protein_coding
description:
  Mitotic spindle midzone-localized microtubule bundling protein; microtubule-associated protein (MAP) family member; required for spindle elongation and stabilization; undergoes cell cycle-regulated degradation by anaphase promoting complex; potential Cdc28p substrate; relative distribution to microtubules decreases upon DNA replication stress; Belongs to the MAP65/ASE1 family.


ensembl_gene_id: YOR059C
symbol: LPL1
gene_biotype: protein_coding
description:
  Lipid droplet phospholipase 1; Phospholipase; contains lipase specific GXSXG motif; maintains lipid droplet (LD) morphology; induced by transcription factor Rpn4p; protein abundance increases in response to DNA replication stress.


ensembl_gene_id: YOR060C
symbol: SLD7
gene_biotype: protein_coding
description:
  Mitochondrial morphogenesis protein SLD7; Protein with a role in chromosomal DNA replication; interacts with Sld3p and reduces its affinity for Cdc45p; deletion mutant has aberrant mitochondria.


ensembl_gene_id: YOR061W
symbol: CKA2
gene_biotype: protein_coding
description:
  Alpha' catalytic subunit of casein kinase 2 (CK2); CK2 is a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; protein abundance increases in response to DNA replication stress; regulates Fkh1p-mediated donor preference during mating-type switching.


ensembl_gene_id: YOR062C
symbol: YOR062C
gene_biotype: protein_coding
description:
  Uncharacterized protein YOR062C; Protein of unknown function; similar to Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; YOR062C has a paralog, YKR075C, that arose from the whole genome duplication.


ensembl_gene_id: YOR063W
symbol: RPL3
gene_biotype: protein_coding
description:
  Ribosomal 60S subunit protein L3; homologous to mammalian ribosomal protein L3 and bacterial L3; plays an important role in function of eIF5B in stimulating 3' end processing of 18S rRNA in context of 80S ribosomes that have not yet engaged in translation; involved in replication and maintenance of killer double stranded RNA virus; Belongs to the universal ribosomal protein uL3 family.


ensembl_gene_id: YOR064C
symbol: YNG1
gene_biotype: protein_coding
description:
  Protein YNG1; Subunit of the NuA3 histone acetyltransferase complex; this complex acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3; shares significant sequence identity with the human candidate tumor suppressor p33-ING1 in C-terminal region.


ensembl_gene_id: YOR065W
symbol: CYT1
gene_biotype: protein_coding
description:
  Cytochrome c1, heme protein, mitochondrial; Cytochrome c1; component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex.


ensembl_gene_id: YOR066W
symbol: MSA1
gene_biotype: protein_coding
description:
  Activator of G1-specific transcription factors MBF and SBF; involved in regulation of the timing of G1-specific gene transcription and cell cycle initiation; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; MSA1 has a paralog, MSA2, that arose from the whole genome duplication.


ensembl_gene_id: YOR067C
symbol: ALG8
gene_biotype: protein_coding
description:
  Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase; Glucosyl transferase; involved in N-linked glycosylation; adds glucose to the dolichol-linked oligosaccharide precursor prior to transfer to protein during lipid-linked oligosaccharide biosynthesis; similar to Alg6p; human homolog ALG8 can complement yeast null mutant; Belongs to the ALG6/ALG8 glucosyltransferase family.


ensembl_gene_id: YOR068C
symbol: VAM10
gene_biotype: protein_coding
description:
  Protein involved in vacuole morphogenesis; acts at an early step of homotypic vacuole fusion that is required for vacuole tethering.


ensembl_gene_id: YOR069W
symbol: VPS5
gene_biotype: protein_coding
description:
  Nexin-1 homolog; required for localizing membrane proteins from a prevacuolar/late endosomal compartment back to late Golgi; structural component of retromer membrane coat complex; forms a retromer subcomplex with Vps17p; required for recruiting the retromer complex to the endosome membranes; VPS5 has a paralog, YKR078W, that arose from the whole genome duplication.


ensembl_gene_id: YOR070C
symbol: GYP1
gene_biotype: protein_coding
description:
  Cis-golgi GTPase-activating protein (GAP) for yeast Rabs; the Rab family members are Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion.


ensembl_gene_id: YOR071C
symbol: NRT1
gene_biotype: protein_coding
description:
  High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; major transporter for 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (acadesine) uptake; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity; Belongs to the purine-cytosine permease (2.A.39) family.


ensembl_gene_id: YOR072W
symbol: YOR072W
gene_biotype: protein_coding
description:
  Uncharacterized protein YOR072W; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive.


ensembl_gene_id: YOR072W-A
symbol: YOR072W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YOR072W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR072W; originally identified by fungal homology and RT-PCR.


ensembl_gene_id: YOR072W-B
symbol: YOR072W-B
gene_biotype: protein_coding
description:
  Uncharacterized protein YOR072W-B; Putative protein of unknown function; identified by expression profiling and mass spectrometry.


ensembl_gene_id: YOR073W
symbol: SGO1
gene_biotype: protein_coding
description:
  Shugoshin; Component of the spindle checkpoint; involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability; recruits condensin to the pericentric region of chromosomes during meiosis; dissociates from pericentromeres when sister kinetochores are under tension; Belongs to the shugoshin family.


ensembl_gene_id: YOR073W-A
symbol: YOR073W-A
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YOR073W-A; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF CDC21/YOR074C; identified by RT-PCR.


ensembl_gene_id: YOR074C
symbol: CDC21
gene_biotype: protein_coding
description:
  Thymidylate synthase; required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S; human homolog TYMSOS can complement yeast cdc21 temperature-sensitive mutant at restrictive temperature.


ensembl_gene_id: YOR075W
symbol: UFE1
gene_biotype: protein_coding
description:
  Syntaxin UFE1; t-SNARE protein required for retrograde vesicular traffic; involved in Sey1p-independent homotypic ER fusion; required for efficient nuclear fusion during mating; forms a complex with the SNAREs Sec22p, Sec20p and Use1p to mediate fusion of Golgi-derived vesicles at the ER; Belongs to the syntaxin family.


ensembl_gene_id: YOR076C
symbol: SKI7
gene_biotype: protein_coding
description:
  Superkiller protein 7; GTP-binding protein that couples the Ski complex and exosome; putative pseudo-translational GTPase involved in 3'-to-5' mRNA decay pathway; interacts with both the cytoplasmic exosome and the Ski complex; eRF3-like domain targets nonstop mRNA for degradation; null mutants have a superkiller phenotype; SKI7 has a paralog, HBS1, that arose from the whole genome duplication; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family.


ensembl_gene_id: YOR077W
symbol: RTS2
gene_biotype: protein_coding
description:
  Basic zinc-finger protein; similar to human and mouse Kin17 proteins which are chromatin-associated proteins involved in UV response and DNA replication.


ensembl_gene_id: YOR078W
symbol: BUD21
gene_biotype: protein_coding
description:
  Bud site selection protein 21; Component of small ribosomal subunit (SSU) processosome; this complex contains U3 snoRNA; required at post-transcriptional step for efficient retrotransposition; absence results in decreased Ty1 Gag:GFP protein levels; originally isolated as bud-site selection mutant that displays a random budding pattern; Belongs to the UTP16 family.


ensembl_gene_id: YOR079C
symbol: ATX2
gene_biotype: protein_coding
description:
  Metal homeostasis factor ATX2; Golgi membrane protein involved in manganese homeostasis; overproduction suppresses the sod1 (copper, zinc superoxide dismutase) null mutation.


ensembl_gene_id: YOR080W
symbol: DIA2
gene_biotype: protein_coding
description:
  Protein DIA2; Origin-binding F-box protein; forms SCF ubiquitin ligase complex with Skp1p and Cdc53p; functions in ubiquitination of silent chromatin structural protein Sir4p; required to target Cdc6p for destruction during G1 phase; required for deactivation of Rad53 checkpoint kinase, completion of DNA replication during recovery from DNA damage, assembly of RSC complex, RSC-mediated transcription regulation, and nucleosome positioning; involved in invasive and pseudohyphal growth; Belongs to the DIA2 family.


ensembl_gene_id: YOR081C
symbol: TGL5
gene_biotype: protein_coding
description:
  Lipase 5; Bifunctional triacylglycerol lipase and LPA acyltransferase; lipid particle-localized triacylglycerol (TAG) lipase involved in triacylglycerol mobilization; catalyzes acylation of lysophosphatidic acid (LPA); potential Cdc28p substrate; TGL5 has a paralog, TGL4, that arose from the whole genome duplication.


ensembl_gene_id: YOR082C
symbol: YOR082C
gene_biotype: protein_coding
description:
  Putative uncharacterized protein YOR082C; Dubious open reading frame; unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YOR083W.


ensembl_gene_id: YOR083W
symbol: WHI5
gene_biotype: protein_coding
description:
  G1-specific transcriptional repressor WHI5; Repressor of G1 transcription; binds to SCB binding factor (SBF) at SCB target promoters in early G1; dilution of Whi5p concentration during cell growth determines cell size; phosphorylation of Whi5p by the CDK, Cln3p/Cdc28p relieves repression and promoter binding by Whi5, and contributes to both the determination of critical cell size at START and cell fate; periodically expressed in G1; Belongs to the WHI5/NRM1 family.


ensembl_gene_id: YOR084W
symbol: LPX1
gene_biotype: protein_coding
description:
  Peroxisomal membrane protein LPX1; Peroxisomal matrix-localized lipase; required for normal peroxisome morphology; contains a peroxisomal targeting signal type 1 (PTS1) and a lipase motif; peroxisomal import requires the PTS1 receptor, Pex5p and self-interaction; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; oleic acid inducible.


ensembl_gene_id: YOR085W
symbol: OST3
gene_biotype: protein_coding
description:
  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 3; Gamma subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins; Belongs to the OST3/OST6 family.


