# geneInfo

ensembl_gene_id: F22F1.1.1
symbol: hil-3
gene_biotype: protein_coding
description:
  Histone H1.3; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.


ensembl_gene_id: F22F7.7a.1
symbol: F22F7.7
gene_biotype: protein_coding
description:
  Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.


ensembl_gene_id: F23B12.5.1
symbol: dlat-1
gene_biotype: protein_coding
description:
  Pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).


ensembl_gene_id: F23B12.6.1
symbol: fntb-1
gene_biotype: protein_coding
description:
  Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.


ensembl_gene_id: F23B12.9.1
symbol: egl-1
gene_biotype: protein_coding
description:
  Programmed cell death activator egl-1; Plays a major role in programmed cell death (PCD or apoptosis) by negatively regulating ced-9. Binds to and directly inhibits the activity of ced-9, releasing the cell death activator ced-4 from a ced- 9/ced-4 containing protein complex and allowing ced-4 to activate the cell-killing caspase ced-3. Required to activate programmed cell death in the sister cells of the serotonergic neurosecretory motor (NSM) neurons during embryogenesis. Required to activate programmed cell death in the sister cells of the M4 motor neuron and I1 pharyngeal neuron du [...]


ensembl_gene_id: F23B2.4.1
symbol: daf-10
gene_biotype: protein_coding
description:
  Intraflagellar transport protein 122 homolog; Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein- coupled receptors (GPCRs). Plays a role in chemotaxis and sensory perception. Required for entry into and exit from the dauer larval stage and this may be mediated by daf-12, daf-16 and daf-41. Controls the behavioral response, namely the avoidance response, and pathogen-responsive gene expression in the response to pathogenic bacteria such as E.coli and P. aeruginosa.


ensembl_gene_id: F23B2.5a.1
symbol: flp-1
gene_biotype: protein_coding
description:
  FMRFamide-like neuropeptides 1; Together with flp-18, plays a homeostatic role by acting on the GABAergic neural transmission at neuromuscular junctions to prevent overexcitation of the locomotor circuit. DPNFLRF-amide: Inhibits the activity of dissected pharyngeal myogenic muscle system; Belongs to the FARP (FMRFamide related peptide) family.


ensembl_gene_id: F23C8.4.2
symbol: ubxn-1
gene_biotype: protein_coding
description:
  UBX domain-containing protein 1; Ubiquitin-binding protein which acts as an adapter for ATPase cdc-48.1 and/or cdc-48.2, conferring substrate specificity. Together with ubxn-2 and ubxn-3, plays a role in hermaphrodite spermatogenesis probably by promoting the degradation of sex determination terminal factor tra-1.


ensembl_gene_id: F23C8.9.1
symbol: tipn-1
gene_biotype: protein_coding
description:
  Protein TIPIN homolog; Required for normal progression of S-phase. Important for cell survival after DNA damage or replication stress. Belongs to the CSM3 family.


ensembl_gene_id: F23F1.5.1
symbol: F23F1.5
gene_biotype: protein_coding
description:
  Snurportin-1; Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs. Belongs to the snurportin family.


ensembl_gene_id: F23F1.8a.1
symbol: rpt-4
gene_biotype: protein_coding
description:
  Probable 26S proteasome regulatory subunit 10B; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).


ensembl_gene_id: F23F12.6.2
symbol: rpt-3
gene_biotype: protein_coding
description:
  Probable 26S proteasome regulatory subunit 6B; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).


ensembl_gene_id: F23H11.2.1
symbol: F23H11.2
gene_biotype: protein_coding
description:
  TATA box-binding protein-associated factor RNA polymerase I subunit B; Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment (By similarity).


ensembl_gene_id: F23H11.9a.1
symbol: crls-1
gene_biotype: protein_coding
description:
  Probable cardiolipin synthase (CMP-forming); Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) by specifically transferring a phosphatidyl group from CDP-diacylglycerol to phosphatidylglycerol (PG). CL is a key phospholipid in mitochondrial membranes and plays important roles in maintaining the functional integrity and dynamics of mitochondria under both optimal and stress conditions; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.


ensembl_gene_id: F23H12.2.1
symbol: tomm-20
gene_biotype: protein_coding
description:
  Mitochondrial import receptor subunit TOM20 homolog; Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins (By similarity). Together with tomm-22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the translocation pore.


ensembl_gene_id: F23H12.4a.1
symbol: sqt-3
gene_biotype: protein_coding
description:
  Cuticle collagen 1; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.


ensembl_gene_id: F23H12.6.1
symbol: gcy-13
gene_biotype: protein_coding
description:
  Receptor-type guanylate cyclase gcy-13; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity).


ensembl_gene_id: F25B3.6.1
symbol: rtfo-1
gene_biotype: protein_coding
description:
  RNA polymerase-associated protein RTF1 homolog; Component of the PAF1 complex which is a multifunctional complex involved in transcription initiation via genetic interactions with TATA-binding proteins, elongation and transcription-coupled histone modification.


ensembl_gene_id: F25B4.1.2
symbol: gcst-1
gene_biotype: protein_coding
description:
  Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.


ensembl_gene_id: F25B4.6.1
symbol: hmgs-1
gene_biotype: protein_coding
description:
  Hydroxymethylglutaryl-CoA synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.


ensembl_gene_id: F25B5.2b.1
symbol: nop-1
gene_biotype: protein_coding
description:
  Pseudocleavage protein nop-1; Required for formation of the pseudocleavage furrow during the first cleavage of the embryo and also mediates aster-induced furrowing during cytokinesis. Promotes cortical recruitment of ani-1 and nmy-2 during pseudocleavage and cytokinesis and promotes the accumulation of actin at furrowing regions. Regulates establishment of embryonic cell polarity.


ensembl_gene_id: F25B5.4a.2
symbol: ubq-1
gene_biotype: protein_coding
description:
  Ubiquitin-related; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involved in protein degrad [...]


ensembl_gene_id: F25B5.5.1
symbol: F25B5.5
gene_biotype: protein_coding
description:
  CDK5RAP1-like protein; Potential regulator of CDK5 activity; Belongs to the methylthiotransferase family. MiaB subfamily.


ensembl_gene_id: F25B5.6b.1
symbol: F25B5.6
gene_biotype: protein_coding
description:
  Putative folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.


ensembl_gene_id: F25C8.3d.1
symbol: unc-80
gene_biotype: protein_coding
description:
  Protein unc-80; Probable component of the nca-1 sodium channel complex, a cation channel that regulates neuronal activity by transmitting depolarization signals to synapses. Regulates the transition from slow to rapid forms of locomotion. Required for localization of nca-1 along axons and in non-synaptic regions. Contributes to endocytosis defects in synaptojanin mutants. Involved in the control of anasthetic response to halothane.


ensembl_gene_id: F25C8.5.1
symbol: ttll-9
gene_biotype: protein_coding
description:
  Probable tubulin polyglutamylase ttll-9; Polyglutamylase that forms polyglutamate side chains on tubulin (By similarity). Acts when complexed with other proteins (Probable). Appears to be dispensable for polar spindle formation in dividing embryonic cells, for cilia-dependent osmotic avoidance and for male mating behavior. Probably by regulating microtubule stability via the glutamylation of tubulin, regulates PLM axon developmental growth.


ensembl_gene_id: F25D1.1a.1
symbol: ppm-1.A
gene_biotype: protein_coding
description:
  Protein phosphatase ppm-1.A; Probable phosphatase which regulates axon termination in ALM and PLM neurons, and synaptic branch extension and/or stabilization in PLM neurons. Plays a role in synapse formation in GABAergic DD motor neurons probably by dephosphorylating pmk-3 thereby negatively regulating a MAP kinase pathway that includes dlk-1, mkk-4 and pmk-3. Belongs to the PP2C family.


ensembl_gene_id: F25D1.4.1
symbol: degt-1
gene_biotype: protein_coding
description:
  DEGenerin-related Touch-involved channel; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.


ensembl_gene_id: F25D7.1.1
symbol: cup-2
gene_biotype: protein_coding
description:
  Derlin-1; Specifically required for the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Belongs to the derlin family.


ensembl_gene_id: F25D7.3a.1
symbol: blmp-1
gene_biotype: protein_coding
description:
  B lymphocyte-induced maturation protein 1 homolog; Transcription factor which binds to enhancer elements in the promoter region of genes. Regulates the expression of the transcription factor bed-3 to control vulval development. Promotes terminal differentiation in the hypodermis and is involved in regulation of gonadal outgrowth and entry into the dauer stage. Regulates the timing of dorsalward migration of the distal tip cells of the hermaphrodite gonad by inhibiting precocious unc-5 and lin-29 expression which in turn prevents early dorsalward turning. Plays a role in male tail tip m [...]


ensembl_gene_id: F25E2.4.1
symbol: ifd-2
gene_biotype: protein_coding
description:
  Intermediate filament protein ifd-2; Cytoplasmic intermediate filaments provide mechanical strength to cells. Not essential protein.


ensembl_gene_id: F25F2.2.1
symbol: cdh-4
gene_biotype: protein_coding
description:
  Cadherin-4; Potential calcium-dependent cell-adhesion protein that controls axon guidance in the ventral cord.


ensembl_gene_id: F25F8.2.1
symbol: glc-2
gene_biotype: protein_coding
description:
  Glutamate-gated chloride channel subunit beta; Glutamate-gated chloride channel subunit; channel properties depend on the subunit composition. Glutamate binding triggers a rapidly reversible current in heteromeric channels formed by glc-1 and glc-2, while the anti-helmintic drug ivermectin and other avermectins trigger a permanently open channel configuration. Channels containing only glc- 2 are activated by glutamate, but not by ivermectin (in vitro). The heteromeric channel formed by glc-1 and glc-2 is also activated by ibotenate, and it is blocked by picrotoxin and flufenamic acid.


ensembl_gene_id: F25G6.3.1
symbol: acr-16
gene_biotype: protein_coding
description:
  Acetylcholine receptor subunit alpha-type acr-16; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane (By similarity). A subunit of the levamisole-insensitive nicotinic receptor.


ensembl_gene_id: F25G6.5b.1
symbol: stdh-4
gene_biotype: protein_coding
description:
  Putative steroid dehydrogenase 4; Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.


ensembl_gene_id: F25G6.8.1
symbol: F25G6.8
gene_biotype: protein_coding
description:
  Signal recognition particle 14 kDa protein; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding (By similarity).


ensembl_gene_id: F25H2.10.1
symbol: rla-0
gene_biotype: protein_coding
description:
  60S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10.


ensembl_gene_id: F25H2.11.1
symbol: tct-1
gene_biotype: protein_coding
description:
  Translationally-controlled tumor protein homolog; Involved in calcium binding and microtubule stabilization. Belongs to the TCTP family.


ensembl_gene_id: F25H2.13.2
symbol: rtel-1
gene_biotype: protein_coding
description:
  Regulator of telomere elongation helicase 1 homolog; ATP-dependent DNA helicase implicated in DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Belongs to the helicase family. RAD3/XPD subfamily.


ensembl_gene_id: F25H2.8.2
symbol: ubc-25
gene_biotype: protein_coding
description:
  Ubiquitin-conjugating enzyme E2 25; Catalyzes the covalent attachment of ubiquitin to other proteins (Potential). Required for the maintenance of neuromuscular function.


ensembl_gene_id: F25H2.9.1
symbol: pas-5
gene_biotype: protein_coding
description:
  Proteasome subunit alpha type-5; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).


ensembl_gene_id: F25H5.4a.3
symbol: eef-2
gene_biotype: protein_coding
description:
  Elongation factor 2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Involved in the morphogenesis of epidermal tissues; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic trans [...]


ensembl_gene_id: F25H8.3b.1
symbol: gon-1
gene_biotype: protein_coding
description:
  A disintegrin and metalloproteinase with thrombospondin motifs gon-1; Secreted metalloprotease required for distal tip cell (DTC) migration along the body wall basement membranes, a key step that promotes gonad morphogenesis. Probably acts by remodeling the basement membrane during cell migration. Required to restrict presynaptic growth at the neuromuscular junctions (NMJ) in late larval stage and in adult motor neurons, probably by controlling collagen IV emb-9 degradation, a component of the synapse basement membrane. Also involved in the organization of adult muscle morphology. Has  [...]


ensembl_gene_id: F25H8.6.1
symbol: bed-3
gene_biotype: protein_coding
description:
  Zinc finger BED domain-containing protein 3; Probable transcription factor involved in vulval organogenesis. During vulval development, may play a role in the regulation of cell cycle regulators such as cul-1. Plays a role in larval molting.


ensembl_gene_id: F26A3.2a.2
symbol: ncbp-2
gene_biotype: protein_coding
description:
  Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi). The CBC complex is involved in miRNA-mediated RNA interference and is required for primary microRNAs (miRNAs) processing. In the CBC complex, ncbp-2 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires ncbp-1 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap stru [...]


ensembl_gene_id: F26B1.2a.1
symbol: hrpk-1
gene_biotype: protein_coding
description:
  Heterogeneous nuclear ribonucleoprotein K homolog; RNA-binding protein which functions together with alg-1, a component of the miRNA loading complex, to modulate the processing and activity of specific miRNAs such as miR-58 and let-7 to regulate gene expression at the post-transcriptional level during embryonic, hypodermal and neuronal development. Promotes the lsy-6-mediated repression of cog-1 in uterine cells. In embryos, may play a role in the DNA damage response.


ensembl_gene_id: F26B1.3.1
symbol: ima-2
gene_biotype: protein_coding
description:
  Importin subunit alpha-2; Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Promotes docking of import substrates to the nuclear envelope. Seems to act as a cytosolic receptor for both simple and bipartite NLS motifs (By similarity).


ensembl_gene_id: F26C11.2.1
symbol: unc-4
gene_biotype: protein_coding
description:
  Homeobox protein unc-4; Transcription factor that regulates synaptic specificity. Determines the pattern of synaptic input to VA motor neurons. Acts together with unc-37 by repressing the expression of VB-specific genes such as ceh-12, thereby preventing the adoption of VB motor neurons. Has no role in axonal guidance or outgrowth. Belongs to the paired homeobox family. Unc-4 subfamily.


ensembl_gene_id: F26D11.11b.1
symbol: let-413
gene_biotype: protein_coding
description:
  Protein lap1; Critical role in assembling adherens junctions; adapter protein involved in polarizing protein trafficking in epithelial cells. Necessary to maintain, not establish, the entire terminal web (organelle-depleted, intermediate filament-rich layer of cytoplasm that underlies the apical microvilli of polarized epithelial cells) or brush border assembly at the apical surface gut cells. Required for correct localization of ifb-2 intermediate filaments in the terminal web. Required for dlg-1 lateral localization. With dlg-1, cooperatively regulates ajm-1 localization to apical ju [...]


ensembl_gene_id: F26E4.1.1
symbol: sur-6
gene_biotype: protein_coding
description:
  Serine/threonine-protein phosphatase 2A regulatory subunit sur-6; Probable regulatory subunit of serine/threonine phosphatase let-92. Together with let-92 and constant regulatory subunit paa-1, positively regulates centriole duplication during early embryonic cell divisions by preventing the degradation of sas-5 and kinase zyg-1. In addition, during vulva development, may play a role with phosphatase let-92 and regulatory subunit paa-1 in the induction of vulva cell precursors by positively regulating let-60/Ras- MAP kinase signaling, probably by promoting lin-45 activation. In intesti [...]


ensembl_gene_id: F26E4.10a.1
symbol: drsh-1
gene_biotype: protein_coding
description:
  Ribonuclease 3; Executes the initial step of microRNA (miRNA) processing in the nucleus, that is the cleavage of pri-miRNA to release pre-miRNA. Involved in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in fertility. Required for the function or synthesis of the let-7 miRNA. Belongs to the ribonuclease III family.


ensembl_gene_id: F26E4.12.1
symbol: gpx-1
gene_biotype: protein_coding
description:
  Glutathione peroxidase 1; May constitute a glutathione peroxidase-like protective system against oxidative stresses.


ensembl_gene_id: F26E4.8b.1
symbol: tba-1
gene_biotype: protein_coding
description:
  Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.


ensembl_gene_id: F26F12.7.1
symbol: let-418
gene_biotype: protein_coding
description:
  Protein let-418; Part of a NuRD (Nucleosome Remodeling and Deacetylase) complex which is implicated in the synMuv B pathway that negatively regulates specification of vulval cell fate. This negative regulation is thought to be mediated via interaction with the promoter of lin-39, a key regulator in vulva development, and is dependent on the presence lin-1. Contributes to negative regulation of lag-2 which is expressed in the gut during larval development. Has a broad role in development. In association with akir-1, plays a role in regulating the transcription of antimicrobial peptide g [...]


ensembl_gene_id: F26F4.10a.2
symbol: rars-1
gene_biotype: protein_coding
description:
  Probable arginine--tRNA ligase, cytoplasmic; Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis.


ensembl_gene_id: F26F4.11.1
symbol: rpb-8
gene_biotype: protein_coding
description:
  Probable DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively (By similarity); Belongs to the eukaryotic RPB8 RNA polymerase subunit family.


ensembl_gene_id: F26F4.3.1
symbol: rom-1
gene_biotype: protein_coding
description:
  Rhomboid-related protein 1; Serine protease which activates lin-3 isoform a in the proximal vulva precursor cells (VPC) during vulva development to transmit the inductive anchor cell signal to the distal VPCs.


ensembl_gene_id: F26G1.4.1
symbol: ttm-2
gene_biotype: protein_coding
description:
  Protein ttm-2; Involved in resistance to B.thuringiensis pore-forming toxin Cry5B downstream of the sek-1 and pmk-1 MAPK kinase pathway.


ensembl_gene_id: F26G1.7.1
symbol: msp-3
gene_biotype: protein_coding
description:
  Major sperm protein 3; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.


ensembl_gene_id: F26H11.2a.1
symbol: nurf-1
gene_biotype: protein_coding
description:
  Nucleosome-remodeling factor subunit NURF301-like; Histone-binding component of a NURF-like (nucleosome remodeling factor-like) complex, which would catalyze ATP-dependent nucleosome sliding and facilitate transcription of chromatin (Probable). Involved in vulval cell fates. Belongs to the BPTF family.


ensembl_gene_id: F26H11.5.2
symbol: exl-1
gene_biotype: protein_coding
description:
  Chloride intracellular channel exl-1; Probable chloride channel; Belongs to the chloride channel CLIC family.


ensembl_gene_id: F26H9.4.1
symbol: nmat-2
gene_biotype: protein_coding
description:
  Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2; Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate. Belongs to the eukaryotic NMN adenylyltransferase family.


ensembl_gene_id: F26H9.5.1
symbol: F26H9.5
gene_biotype: protein_coding
description:
  Probable phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine.


ensembl_gene_id: F26H9.7.1
symbol: uev-3
gene_biotype: protein_coding
description:
  Ubiquitin-conjugating enzyme E2 variant 3; Possible negative regulator of polyubiquitination (By similarity). May modulate the activity of the p38 MAP kinase pnk-3. May have a role in axon termination and synaptic transmission at motor and mechanosensory neurons. Plays a role in intraflagellar transport in cilia and cilium length regulation ; Belongs to the ubiquitin-conjugating enzyme family.


ensembl_gene_id: F27C1.8.1
symbol: dpy-5
gene_biotype: protein_coding
description:
  Cuticle collagen dpy-5; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.


ensembl_gene_id: F27D4.1.1
symbol: F27D4.1
gene_biotype: protein_coding
description:
  Probable electron transfer flavoprotein subunit alpha, mitochondrial; The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF- ubiquinone oxidoreductase (ETF dehydrogenase) (By similarity).


ensembl_gene_id: F27D9.1a.1
symbol: unc-18
gene_biotype: protein_coding
description:
  Putative acetylcholine regulator unc-18; May participate in the axonal transport system and influences the acetylcholine flow in motor neurons. Probably by regulating neuronal transmission downstream of lin-3 and receptor lin-23 and phospholipase plc-3 and upstream of innexin unc-7 and egl-4/PKG in ALA neurons, involved in the decrease in pharyngeal pumping during the quiescent state that precedes each larval molt ; Belongs to the STXBP/unc-18/SEC1 family.


ensembl_gene_id: F27D9.5.2
symbol: pcca-1
gene_biotype: protein_coding
description:
  Propionyl-CoA carboxylase alpha chain, mitochondrial; This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other metabolites. Propionyl-CoA carboxylase catalyzes the carboxylation of propionyl- CoA/propanoyl-CoA to D-methylmalonyl-CoA/(S)-methylmalonyl-CoA (By similarity). Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl car [...]


ensembl_gene_id: F27E11.1a.1
symbol: slc-28.1
gene_biotype: protein_coding
description:
  Sodium/nucleoside cotransporter; Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.


ensembl_gene_id: F27E11.3.1
symbol: cfz-2
gene_biotype: protein_coding
description:
  Frizzled-2; Receptor for Wnt proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of gsk-3 kinase, nuclear accumulation of beta- catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of gsk-3 kinase. Both pathways seem to inv [...]


ensembl_gene_id: F27E5.1.1
symbol: asah-2
gene_biotype: protein_coding
description:
  Probable acid ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.


ensembl_gene_id: F28B12.2i.1
symbol: egl-44
gene_biotype: protein_coding
description:
  Transcription enhancer factor-like protein egl-44; Acts upstream of egl-46 to prevent touch cell differentiation in FLP neurons. Also promotes HSN neuron development. In association with egl-46, regulates cell cycle exit in the neuronal Q cell lineage. May be involved in thermal stress response downstream of yap-1.


ensembl_gene_id: F28B12.3.1
symbol: vrk-1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase VRK1; Serine/threonine kinase that phosphorylates baf-1, thus regulating the association of baf-1 with chromatin and nuclear membrane proteins during nuclear envelope formation. May act through the egl-17 signaling pathway. Essential in hermaphrodites for formation of the vulva, uterus, and uterine seam cells and for development and maintenance of the somatic gonad and thus the germ line. Acts to prevent cep-1 from triggering an inappropriate cell cycle arrest, thereby promoting germ cell proliferation. Regulates anchor cell polarity and the timing of an [...]


ensembl_gene_id: F28B3.7a.1
symbol: him-1
gene_biotype: protein_coding
description:
  Structural maintenance of chromosomes protein 1; Involved in chromosome cohesion during cell cycle and in DNA repair (By similarity). Required for chromosome segregation during mitosis. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped (By similarity). At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate (By similarity).


ensembl_gene_id: F28C1.2b.1
symbol: egl-10
gene_biotype: protein_coding
description:
  Regulator of G-protein signaling egl-10; Involved in egg-laying and locomotion. May regulate G protein goa-1 signaling.


ensembl_gene_id: F28D1.10.2
symbol: gex-3
gene_biotype: protein_coding
description:
  Membrane-associated protein gex-3; Rac effector required for tissue morphogenesis, cell migrations and egg laying. May play a role in egg laying and in yolk protein clatherin-mediated endocytosis by oocytes during oogenesis.


ensembl_gene_id: F28D1.11.1
symbol: dpm-3
gene_biotype: protein_coding
description:
  Probable dolichol-phosphate mannosyltransferase subunit 3; Stabilizer subunit of the dolichol-phosphate-mannose synthase complex.


ensembl_gene_id: F28F8.3.2
symbol: lsm-5
gene_biotype: protein_coding
description:
  U6 snRNA-associated Sm-like protein LSm5; Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA; Belongs to the snRNP Sm proteins family.


ensembl_gene_id: F28F8.6.1
symbol: atx-3
gene_biotype: protein_coding
description:
  Ataxin-3 homolog; Acts as chain editing deubiquitinating enzyme that binds and cleaves 'Lys-48'-linked polyubiquitin chains, with a preference for chains containing four or more ubiquitin molecules thereby modulating protein degradation by the ubiquitin-proteasome pathway. Probably by regulating the IGF-1-insulin-like pathway, regulates lifespan. Regulates germline DNA double-strand-break repair and apoptosis in response to DNA damage by recruiting E4 ubiquitin- protein ligase ufd-2 to DNA repair foci. Interacts with key regulators of transcription and represses transcription (By simil [...]


ensembl_gene_id: F28F9.1.1
symbol: zag-1
gene_biotype: protein_coding
description:
  Zinc finger E-box-binding homeobox protein zag-1; Down-regulates expression of genes involved in either the synthesis or reuptake of serotonin, dopamine and GABA. Acts as a transcriptional repressor to regulate multiple, discrete, neuron- specific aspects of terminal differentiation, including cell migration, axonal development and gene expression. Required for axon guidance. Involved in the proper development of the pharynx. Directly represses its own transcription by interacting with conserved E-box sequence motifs 5'-CACCTG-3' in its own promoter.


ensembl_gene_id: F28H1.3.4
symbol: aars-2
gene_biotype: protein_coding
description:
  Alanine--tRNA ligase, cytoplasmic; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family.


ensembl_gene_id: F28H6.1a.1
symbol: akt-2
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase akt-2; Acts downstream of PI3 kinase age-1 and kinase pdk-1 in the daf-2/insulin receptor-like transduction pathway. Essential role in regulating developmental arrest at the dauer stage. Phosphorylates Forkhead-related daf- 16 and the longevity-promoting skn-1 transcription factors, which inhibits their entry into the nucleus and antagonizes their functions. Role in immune function and pathogen resistance. Downstream of age-1 and together with akt-2 and sgk-1, promotes cell survival during embryonic development. Belongs to the protein kinase superfamily. [...]


ensembl_gene_id: F28H7.4.1
symbol: selt-1.2
gene_biotype: protein_coding
description:
  Thioredoxin reductase-like selenoprotein T homolog selt-1.2; Probably has thioredoxin reductase-like oxidoreductase activity; Belongs to the SelWTH family. SELT subfamily.


ensembl_gene_id: F29B9.1.2
symbol: F29B9.1
gene_biotype: protein_coding
description:
  Protein-lysine N-methyltransferase CELE_F29B9.1; S-adenosyl-L-methionine-dependent protein-lysine N- methyltransferase that methylates elongation factor 1-alpha. Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.


ensembl_gene_id: F29B9.2c.1
symbol: jmjd-1.2
gene_biotype: protein_coding
description:
  Lysine-specific demethylase 7 homolog; Histone demethylase required for nervous system development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3, thereby playing a central role in histone code. Promotes mitochondrial stress- induced longevity ; Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily.


ensembl_gene_id: F29B9.4c.1
symbol: psr-1
gene_biotype: protein_coding
description:
  Bifunctional arginine demethylase and lysyl-hydroxylase psr-1; Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase.


ensembl_gene_id: F29B9.6.2
symbol: ubc-9
gene_biotype: protein_coding
description:
  SUMO-conjugating enzyme UBC9; Accepts the ubiquitin-like protein smo-1 from the aos-1-uba-2 E1 complex and catalyzes its covalent attachment to other proteins with the help of an E3 ligase such as gei-17. Required to sumoylate the ETS transcription factor lin-1 and the Polycomb protein sop-2. Required for embryonic development, fertility, vulval morphogenesis and inhibition of vulval cell fates. Belongs to the ubiquitin-conjugating enzyme family.


ensembl_gene_id: F29C12.4.2
symbol: gfm-1
gene_biotype: protein_coding
description:
  Elongation factor G, mitochondrial; Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.


ensembl_gene_id: F29C4.1a.1
symbol: daf-1
gene_biotype: protein_coding
description:
  Cell surface receptor daf-1; Controls the dauer/nondauer developmental decision in a range of environmental conditions. Involved in regulating entry into quiescence triggered by satiety. Involved in sensitivity to CO2 levels.


ensembl_gene_id: F29C4.6.1
symbol: tut-1
gene_biotype: protein_coding
description:
  Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position; Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.


ensembl_gene_id: F29C4.8j.1
symbol: col-99
gene_biotype: protein_coding
description:
  Putative cuticle collagen 99; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment (By similarity).


ensembl_gene_id: F29D10.4.1
symbol: hum-1
gene_biotype: protein_coding
description:
  Heavy chain, Unconventional Myosin; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.


ensembl_gene_id: F29D11.1.1
symbol: lrp-1
gene_biotype: protein_coding
description:
  Low-density lipoprotein receptor-related protein; May act as a receptor for the endocytosis of extracellular ligands such as chylomicron remnants, protease-inhibitor complexes and vitellogenin; Belongs to the LDLR family.


ensembl_gene_id: F29D11.2.1
symbol: capg-1
gene_biotype: protein_coding
description:
  Condensin complex subunit capg-1; Member of two distinct condensin I complexes, the condensin I complex and the condensin I-like dosage compensation complex. The condensin I complex is required for conversion of interphase chromatin into mitotic-like condensed chromosomes and for chromosome segregation in meiosis and mitosis. As a member of the condensin I complex, further controls crossover number and distribution in meiosis by restricting double strand break formation, probably by influencing higher-order chromosome structure. Regulatory subunit of the condensin I-like dosage compens [...]


ensembl_gene_id: F29F11.1.1
symbol: sqv-4
gene_biotype: protein_coding
description:
  UDP-glucose 6-dehydrogenase; Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate. Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.


ensembl_gene_id: F29F11.3.1
symbol: tut-2
gene_biotype: protein_coding
description:
  Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with tut-1/ctu-1 that ligates sulfur from thiocarboxylated urm-1 onto the uridine of tRNAs at wobble position.


ensembl_gene_id: F29F11.5d.1
symbol: ceh-22
gene_biotype: protein_coding
description:
  Homeobox protein ceh-22; Involved in combinatorial activation of gene expression in pharyngeal muscle. Specifically binds a site necessary for activity of the B subelement of myo-2 enhancer.


ensembl_gene_id: F29F11.6.1
symbol: gsp-1
gene_biotype: protein_coding
description:
  Serine/threonine-protein phosphatase PP1-alpha; Serine/threonine-protein phosphatase which antagonizes the function of air-2 in the regulation of chromosome cohesion. Dephosphorylates histone H3 at 'Ser-10'. Dephosphorylates translation initiation factor eIF2alpha. Involved in the activation of chloride channel clh-3 during cell swelling and meiotic maturation. Belongs to the PPP phosphatase family. PP-1 subfamily.


ensembl_gene_id: F29G9.2a.1
symbol: picc-1
gene_biotype: protein_coding
description:
  PAC-1 interacting and coiled-coil domain-containing protein 1; Linker protein which helps to recruit the Rho GTPase- activating protein, pac-1, to adherens junctions.


ensembl_gene_id: F29G9.4b.1
symbol: fos-1
gene_biotype: protein_coding
description:
  Transcription factor fos-1; Developmentally regulated transcription factor which binds and recognizes the enhancer DNA sequence 5'-TGA[CG]TCA-3'. [Isoform b]: Required for ovulation. Controls plc-1 expression in the spermatheca to regulate spermathecal valve dilation. Acts with hda-1 as a downstream repressor of the kgb-1 mediated stress response pathway that transcriptionally represses genes involved in the response to heavy metals, such as kreg-1 ; Belongs to the bZIP family. Fos subfamily.


ensembl_gene_id: F29G9.5.1
symbol: rpt-2
gene_biotype: protein_coding
description:
  Probable 26S proteasome regulatory subunit 4; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). May play a role in the degradation of microtubule severing protein mei-1.


ensembl_gene_id: F30A10.10.1
symbol: usp-48
gene_biotype: protein_coding
description:
  Ubiquitin carboxyl-terminal hydrolase usp-48; Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin (By similarity). Involved in the processing of poly- ubiquitin precursors as well as that of ubiquitinated proteins (By similarity). Required post-developmentally to restrict the plasticity of epidermal cells, probably by regulating gene expression ; Belongs to the peptidase C19 family.


ensembl_gene_id: F30A10.8.1
symbol: stn-1
gene_biotype: protein_coding
description:
  Syntrophin-1; Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex (DGC). May also act by slowing calcium channel activity via a direct or indirect mechanism potentially involving other second messengers. Plays an early role in the formation of the neuromuscular junction and is necessary for muscle maintenance.


ensembl_gene_id: F30B5.1.1
symbol: dpy-13
gene_biotype: protein_coding
description:
  Cuticle collagen dpy-13; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Mutations in dpy-13 affects the body shape.


ensembl_gene_id: F30H5.2.1
symbol: nlp-32
gene_biotype: protein_coding
description:
  Neuropeptide-like protein 32; May have antimicrobial activity; Belongs to the YARP (YGGW-amide related peptide) family.


ensembl_gene_id: F31B12.1a.1
symbol: plc-1
gene_biotype: protein_coding
description:
  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. plc-1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine-exchange factor (RasGEF) activity (By similarity). By activating IP3 receptor itr-1-mediated intracellular Ca(2+) release via the production of IP3, regulates ovulation by controlling contraction and/or dilation of the di [...]


ensembl_gene_id: F31C3.1.2
symbol: cyn-5
gene_biotype: protein_coding
description:
  Peptidyl-prolyl cis-trans isomerase 5; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.


ensembl_gene_id: F31C3.5.1
symbol: psf-2
gene_biotype: protein_coding
description:
  Probable DNA replication complex GINS protein PSF2; The GINS complex plays an essential role in the initiation of DNA replication.


ensembl_gene_id: F31D5.3b.1
symbol: cpna-1
gene_biotype: protein_coding
description:
  Copine family protein 1; Involved in the assembly of dense bodies and M lines during body wall muscle development. Acts by recruiting downstream of integrin-associated protein pat-6/actopaxin several dense bodies and M line components including unc-89, lim-9, scpl-1 and unc-96 to integrin- mediated attachment sites.


ensembl_gene_id: F31E3.1.1
symbol: ceh-20
gene_biotype: protein_coding
description:
  Homeobox protein ceh-20; Transcription factor that binds to the 5'-TGATNNAT(G/T)(G/A)- 3' PBC/Hox lineage enhancer region of sem-2 to promote cell fate specification in the postembryonic mesoderm (also known as the M lineage). Has a role in the mig-13 pathway to promote the guidance, migration and positioning of Q neuroblasts and their descendants along the anteroposterior body axis and the anterior migration of BDU interneurons. Also required for normal vulval formation.


ensembl_gene_id: F31E3.3.1
symbol: rfc-4
gene_biotype: protein_coding
description:
  Replication factor C subunit 4; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. This subunit may be involved in the elongation of the multiprimed DNA template (By similarity).


ensembl_gene_id: F31E3.5.3
symbol: eef-1A.1
gene_biotype: protein_coding
description:
  Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.


ensembl_gene_id: F31E8.2b.1
symbol: snt-1
gene_biotype: protein_coding
description:
  Synaptotagmin-1; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone (By similarity). Involved in necrotic cell death.


ensembl_gene_id: F31F6.6.1
symbol: nac-1
gene_biotype: protein_coding
description:
  Sodium-dependent low-affinity dicarboxylate transporter 1; Low affinity sodium-dicarboxylate cotransporter that accepts a range of tricarboxylic acid-cycle intermediates with 4-5 carbon atoms. There is no interaction with monocarboxylates. Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.


ensembl_gene_id: F32A11.6.1
symbol: moe-3
gene_biotype: protein_coding
description:
  CCCH-type zinc finger protein moe-3; Zinc-finger protein that may play a role in oocyte maturation and fertility.


ensembl_gene_id: F32A5.6.1
symbol: prx-13
gene_biotype: protein_coding
description:
  Probable peroxisomal membrane protein PEX13; Component of the peroxisomal translocation machinery with PEX14 and PEX17. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PAS10/PEX5) (By similarity); Belongs to the peroxin-13 family.


ensembl_gene_id: F32A5.7.1
symbol: lsm-4
gene_biotype: protein_coding
description:
  Probable U6 snRNA-associated Sm-like protein LSm4; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.


ensembl_gene_id: F32A6.3c.1
symbol: vps-41
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways. Believed to act in part as a core component of the putative HOPS endosomal tethering complex which is proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to rab-7 on the late endosomal membrane  [...]


ensembl_gene_id: F32A7.3c.2
symbol: eva-1
gene_biotype: protein_coding
description:
  Protein eva-1; Acts as a receptor for slt-1. Required for the guidance of the AVM pioneer axon to the ventral nerve cord. Acts as a unc-40 coreceptor to enhance the sensitivity of unc-40 to the madd-4 midline guidance cue to guide muscle arm extensions (muscle arms) and AVM mechanosensory axons towards the dorsoventral midline. Belongs to the EVA1 family.


ensembl_gene_id: F32A7.6.1
symbol: aex-5
gene_biotype: protein_coding
description:
  Endoprotease aex-5; Probable serine endoprotease which cleaves preproteins at paired basic amino acids. May process FMRFamide-like (flp) and neuropeptide-like protein (nlp) neuropeptides. In muscles, involved in neuronal retrograde signaling by regulating presynaptic activity and localization of synaptic vesicle fusion protein unc-13 at the neuromuscular junction (NMJ). Acts in the intestine to regulate anterior body muscle contractions (aBOC) and the expulsion steps during the defecation motor program (DMP). Probably by regulating DMP, required for fatty acid uptake by intestinal cell [...]


ensembl_gene_id: F32B4.4a.1
symbol: F32B4.4
gene_biotype: protein_coding
description:
  Pharyngeal muscle protein 2; Involved in pharyngeal muscle development and ensures pharyngeal grinder function during feeding. Plays a role in the defense against the accumulation of ingested live pathogenic bacteria in the intestine. Has a role in the determination of life span.


ensembl_gene_id: F32B5.8a.1
symbol: cpz-1
gene_biotype: protein_coding
description:
  Cathepsin Z-1; Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity (By similarity). Plays an essential role in molting, a process during larval stages in which a new cuticle is formed and the old cuticle is shed. Probably, required for the degradation of the old cuticle. Belongs to the peptidase C1 family.


ensembl_gene_id: F32B6.1.1
symbol: nhr-4
gene_biotype: protein_coding
description:
  Nuclear hormone receptor family member nhr-4; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family.


ensembl_gene_id: F32B6.6.1
symbol: msp-77
gene_biotype: protein_coding
description:
  Major sperm protein 77/79; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.


ensembl_gene_id: F32D1.10.1
symbol: mcm-7
gene_biotype: protein_coding
description:
  DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]


ensembl_gene_id: F32D1.1a.2
symbol: figl-1
gene_biotype: protein_coding
description:
  Fidgetin-like protein 1; Has a role in spindle assembly which acts in the progression through mitosis during embryogenesis. Required for fertility.


ensembl_gene_id: F32D1.5a.1
symbol: F32D1.5
gene_biotype: protein_coding
description:
  GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.


ensembl_gene_id: F32D8.6.1
symbol: emo-1
gene_biotype: protein_coding
description:
  Protein transport protein Sec61 subunit gamma; Required for oocyte development and ovulation. Required for the translocation of secretory and transmembrane proteins into the endoplasmic reticulum in vitro ; Belongs to the SecE/SEC61-gamma family.


ensembl_gene_id: F32E10.2.3
symbol: cec-4
gene_biotype: protein_coding
description:
  Chromo domain-containing protein cec-4; Chromatin anchor protein which binds to methylated lysine residues on histone H3, thereby recruiting heterochromatin to the nuclear periphery. May be required for the correct positioning of chromatin and nucleoli in embryos.


ensembl_gene_id: F32E10.4.1
symbol: ima-3
gene_biotype: protein_coding
description:
  Importin subunit alpha-3; Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Promotes docking of import substrates to the nuclear envelope. Seems to act as a cytosolic receptor for both simple and bipartite NLS motifs. Necessary for correct nucleoporin localization within the germline. Belongs to the importin alpha family.


ensembl_gene_id: F32G8.6.1
symbol: cat-4
gene_biotype: protein_coding
description:
  GTP cyclohydrolase 1; Involved in serotonin and dopamine biosynthesis that affects movement, mating behavior, foraging behavior, and cell migration.


ensembl_gene_id: F32H2.1a.1
symbol: snpc-4
gene_biotype: protein_coding
description:
  snRNA-activating protein complex subunit 4 homolog; Binds to the promoter regions of RNA polymerase II and III small-nuclear RNA genes, type 3 RNA polymerase III non-coding RNA genes, small nucleolar RNAs and transfer RNA genes. Required for expression of mature 21U-RNAs.


ensembl_gene_id: F32H2.2b.2
symbol: mdt-31
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 31; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).


ensembl_gene_id: F32H2.3.1
symbol: spd-2
gene_biotype: protein_coding
description:
  Spindle-defective protein 2; Required both for centrosome duplication and maturation. Required for pericentriolar material (PCM) recruitment.


ensembl_gene_id: F33A8.1.1
symbol: let-858
gene_biotype: protein_coding
description:
  Pre-mRNA-splicing factor CWC22 homolog; Required for pre-mRNA splicing and for exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay (By similarity). Required for early embryogenesis and tissue differentiation; Belongs to the CWC22 family.


ensembl_gene_id: F33A8.5.1
symbol: sdhd-1
gene_biotype: protein_coding
description:
  Putative succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).


ensembl_gene_id: F33D4.2a.1
symbol: itr-1
gene_biotype: protein_coding
description:
  Inositol 1,4,5-trisphosphate receptor itr-1; Receptor for inositol 1,4,5-trisphosphate, a second messenger that regulates intracellular calcium homeostasis. Binds in vitro to both inositol 1,4,5-trisphosphate (1,4,5-InsP3) and inositol 2,4,5-trisphosphate (2,4,5-InsP3) with high affinity and does not discriminate between the phosphate at 1 or 2 position. Can also bind inositol 1,3,4,5-tetrakisphosphate (1,3,4,5-InsP4) and inositol 4,5-bisphosphate (4,5-InsP2), but with lower affinity. Acts as a timekeeper/rhythm generator via calcium signaling, affecting the defecation cycle and pharyn [...]


ensembl_gene_id: F33D4.3.1
symbol: flp-13
gene_biotype: protein_coding
description:
  FMRFamide-like neuropeptides 13; FMRFamides and FMRFamide-like peptides are neuropeptides.  APEASPFIRF-amide: Inhibits muscle tension in somatic muscle. Potent inhibitor of the activity of the dissected pharyngeal myogenic muscle system. [SPSAVPLIRF-amide]: Acts as a ligand for the npr-22 receptor in vitro. [ASSAPLIRF-amide]: Acts as a ligand for the npr-22 receptor in vitro; Belongs to the FARP (FMRFamide related peptide) family.


ensembl_gene_id: F33D4.4.1
symbol: F33D4.4
gene_biotype: protein_coding
description:
  Putative sphingolipid delta(4)-desaturase; Acts as a sphingolipid delta(4)-desaturase; Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.


ensembl_gene_id: F33E2.2a.1
symbol: dlk-1
gene_biotype: protein_coding
description:
  Mitogen-activated protein kinase kinase kinase dlk-1; Component of a MAP kinase pathway that functions presynaptically to regulate synaptic architecture and presynaptic differentiation. Phosphorylates and activates mkk-4. Has a role in axonal regrowth following injury and synaptogenesis. Also promotes tubulin post-translational modifications that protect microtubules. Plays a role in cilium length regulation, possibly by reducing rab-5 mediated endocytosis, and may also have a role in intraflagellar transport in cilia. Plays a role in the formation of muscle connections, also called mu [...]


ensembl_gene_id: F33H1.1b.1
symbol: daf-19
gene_biotype: protein_coding
description:
  RFX-like transcription factor daf-19; May be a transcription factor that regulates some genes of ciliated sensory neurons. May activate the expression of the shared components of sensory cilia, but not the cell-type-specific expression; Belongs to the RFX family.


ensembl_gene_id: F33H2.5.1
symbol: pole-1
gene_biotype: protein_coding
description:
  DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.


ensembl_gene_id: F34D6.3.1
symbol: sup-9
gene_biotype: protein_coding
description:
  Two pore potassium channel protein sup-9; Potassium channel involved in coordination of muscle contraction. Activity is regulated by sup-18 ; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.


ensembl_gene_id: F35B12.5a.2
symbol: sas-5
gene_biotype: protein_coding
description:
  Spindle assembly abnormal protein 5; Required for centrosome duplication. Essential for daughter- centriole formation. Requires both maternal and partenal expression, suggesting that it regulates centriole duplication during both spermatogenesis and early embryogenesis.


ensembl_gene_id: F35B3.5c.1
symbol: ptrn-1
gene_biotype: protein_coding
description:
  Patronin (microtubule-binding protein) homolog; Required for microtubule stability and anchorage by binding to the minus ends of microtubules. Acts redundantly with noca-1 to control circumferential microtubule assembly along the body which is necessary for larval development, viability, morphology and integrity of the epidermis. Promotes microtubule stability and polymerization in neurons. Involved in the maintenance of neurite morphology in ALM and PLM neurons. May play a role in synaptic protein localization in the PLM neuron. May act upstream of dlk-1 in neuronal regeneration. Play [...]


ensembl_gene_id: F35C8.3.1
symbol: jkk-1
gene_biotype: protein_coding
description:
  Dual specificity mitogen-activated protein kinase kinase jkk-1; Dual specificity protein kinase which acts as an essential component of the JNK signal transduction pathway. May phosphorylate jnk-1. Plays a role in coordinating locomotion via D-type GABAergic motoneurons and in regulating synaptic vesicle transport downstream of adapter protein unc-16 and probably by activating jnk-1. Positively regulates lifespan. Upon environmental stress such as heat stress regulates daf-16 nuclear translocation probably by activating jnk-1. Regulates germline cell apoptosis in response to heavy meta [...]


ensembl_gene_id: F35C8.4.1
symbol: syx-3
gene_biotype: protein_coding
description:
  Putative syntaxin-3; Potentially involved in docking of synaptic vesicles at presynaptic active zones (By similarity). Acts in the intestine to regulate anterior body muscle contractions (aBOC) and the expulsion steps during the defecation motor program (DMP).


ensembl_gene_id: F35C8.6.1
symbol: pfn-2
gene_biotype: protein_coding
description:
  Profilin-2; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG (By similarity).


ensembl_gene_id: F35D11.11b.1
symbol: che-10
gene_biotype: protein_coding
description:
  Rootletin; Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus. Required for cilia integrity and function in sensory neurons. Maintains cilia integrity, partly by modulating the assembly and transport of intraflagellar proteins along the ciliary axoneme. Required for normal mating behavior and normal responses to environmental and chemical stimuli.


ensembl_gene_id: F35D2.5a.1
symbol: syd-1
gene_biotype: protein_coding
description:
  Rho GTPase-activating protein syd-1; Probable GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Regulates the localization and assembly of presynaptic components during presynaptic development and is required for specifying the identity of axons during initial polarity acquisition. In these roles it is thought to act cell autonomously downstream of syg-1 and syg-2 and upstream of syd-2, possibly as a positive regulator of the latter. Required for the control of movement, egg-laying and the correct localization of elks-1.


ensembl_gene_id: F35D6.1a.1
symbol: fem-1
gene_biotype: protein_coding
description:
  Sex-determining protein fem-1; Sex-determining protein; essential for the adoption of the male sexual fate in all tissues. Substrate recognition subunit of the cullin-RING-based CBC(fem-1) (Cul2-ElonginB-ElonginC) E3 ubiquitin- protein ligase complex which mediates in association with cofactors fem-2 and fem-3 the ubiquitination and subsequent proteasomal degradation of tra-1.


ensembl_gene_id: F35E8.12.1
symbol: nhr-108
gene_biotype: protein_coding
description:
  Nuclear hormone receptor family member nhr-108; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family.


ensembl_gene_id: F35F11.1.1
symbol: cdc-73
gene_biotype: protein_coding
description:
  Cell division cycle protein 73; Component of the PAF1 complex which is a multifunctional complex involved in transcription initiation via genetic interactions with TATA-binding proteins, elongation and transcription-coupled histone modification; Belongs to the CDC73 family.


ensembl_gene_id: F35G12.3a.2
symbol: sel-5
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase sel-5; Serine/threonine-protein kinase which may play a role in lin- 12-mediated cell-fate decisions.


ensembl_gene_id: F35G12.4c.1
symbol: wdr-48
gene_biotype: protein_coding
description:
  WD repeat-containing protein 48 homolog; Together with wdr-20, binds to and stimulates the activity of the deubiquitinating enzyme usp-46, leading to deubiquitination and stabilization of the glr-1 glutamate receptor.


ensembl_gene_id: F35G12.6.1
symbol: mab-21
gene_biotype: protein_coding
description:
  Protein male abnormal 21; Acts in a cell autonomous fashion to specify the properties of the sensory ray and non-autonomously in the choice of hypodermal versus neuroblast cell fate. Belongs to the mab-21 family.


ensembl_gene_id: F35G12.8.2
symbol: smc-4
gene_biotype: protein_coding
description:
  Structural maintenance of chromosomes protein 4; Central component of the condensin I complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin I complex introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases. Converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (By similarity). Also a central component of the condensin II complex, a complex that seems to play a role in prophase chromosome condensation. Both the condensin complex I and II play a role in  [...]


ensembl_gene_id: F35G12.9.2
symbol: apc-11
gene_biotype: protein_coding
description:
  Anaphase-promoting complex subunit 11; Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins. Developmental role in early embryogenesis and the metaphase to anaphase transition in meiosis and mitosis. In vitro, recruits the ubiquitin-conjugating enzyme ubc-2 to exert ubiquitin ligase activity. Belongs to the RING-box family.


ensembl_gene_id: F35G2.4.1
symbol: phy-2
gene_biotype: protein_coding
description:
  Prolyl 4-hydroxylase subunit alpha-2; Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins; Belongs to the P4HA family.


ensembl_gene_id: F35H10.4.1
symbol: vha-5
gene_biotype: protein_coding
description:
  V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.


ensembl_gene_id: F35H10.7a.2
symbol: nprl-3
gene_biotype: protein_coding
description:
  GATOR complex protein NPRL3; As a component of the GATOR complex may function in the amino acid-sensing branch of the TORC1 signaling pathway.


ensembl_gene_id: F35H12.3.1
symbol: sel-12
gene_biotype: protein_coding
description:
  Presenilin sel-12; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1). Provides the major presenilin function compared to hop-1 and spe-4. Required cell-autonomously for correct neurite connectivity of the AIY cholinergic interneurons and their correct functioning in thermotaxis. Required for mesodermal patterning of muscle function. Promotes basement membrane gap formation during tissue remodeling ; Belongs to the peptidase A22A family.


ensembl_gene_id: F35H8.3.1
symbol: zfp-2
gene_biotype: protein_coding
description:
  Zinc finger protein zfp-2; Probable zinc finger transcription factor that acts as a transcriptional repressor. Acts redundantly with the transcriptional repressor lin-35 to control the development of somatic gonad lineages. May, in addition, suppress sensitivity to RNAi.


ensembl_gene_id: F35H8.7.1
symbol: wee-1.1
gene_biotype: protein_coding
description:
  Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase wee-1.1; Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.


ensembl_gene_id: F36A4.10.1
symbol: col-34
gene_biotype: protein_coding
description:
  Cuticle collagen 34; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.


ensembl_gene_id: F36A4.7.2
symbol: ama-1
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerase II subunit RPB1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cl [...]


ensembl_gene_id: F36D3.2.1
symbol: nhr-54
gene_biotype: protein_coding
description:
  Nuclear hormone receptor family member nhr-54; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family.


ensembl_gene_id: F36D4.3b.1
symbol: hum-2
gene_biotype: protein_coding
description:
  Dilute domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.


ensembl_gene_id: F36D4.5a.1
symbol: F36D4.5
gene_biotype: protein_coding
description:
  Desumoylating isopeptidase 1 homolog; Protease which deconjugates SUMO from some substrate proteins. Has isopeptidase but not SUMO-processing activity (By similarity). Collaborates with ubql-1 in the export of ubiquitinated proteins from the nucleus to the cytoplasm.


ensembl_gene_id: F36F2.6.1
symbol: fcp-1
gene_biotype: protein_coding
description:
  RNA polymerase II subunit A C-terminal domain phosphatase; During the late stages of oogenesis, dephosphorylates 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit ama-1. Similarly, dephosphorylates 'Ser-5' of ama-1 in early embryonic cells prior to the activation of the zygotic transcription program at the 4-cell embryonic stage. May dephosphorylate 'Ser-2' of the ama-1 heptad repeats YSPTSPS in embryonic somatic and germline cells.


ensembl_gene_id: F36H1.4f.1
symbol: lin-3
gene_biotype: protein_coding
description:
  Protein lin-3; Probable ligand for tyrosine kinase receptor let-23. Essential for vulval induction, where it acts downstream of the synthetic multivulva (synMuv) class genes. Probably by activating let-23, phospholipase plc-3 and inositol 1,4,5-trisphosphate receptor itr-1 signaling cascade, plays a role in ovulation by promoting gonadal sheath cell contractions and spermatheca dilatation during ovulation. Probably by regulating neuronal transmission in ALA neurons, mediates the decrease in pharyngeal pumping and locomotion during the quiescent state that precedes each larval molt, by  [...]


ensembl_gene_id: F36H1.5c.1
symbol: hrg-4
gene_biotype: protein_coding
description:
  Heme transporter hrg-4; Heme transporter that mediates heme uptake across the plasma membrane; Belongs to the HRG family.


ensembl_gene_id: F36H1.6.1
symbol: alh-3
gene_biotype: protein_coding
description:
  10-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.


ensembl_gene_id: F37A4.8.1
symbol: isw-1
gene_biotype: protein_coding
description:
  Chromatin-remodeling complex ATPase chain isw-1; Energy-transducing component of a NURF-like (nucleosome- remodeling factor-like) complex, which would catalyze ATP-dependent nucleosome sliding and facilitate transcription of chromatin (Probable). Involved in vulval cell fates. Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.


ensembl_gene_id: F37A4.9.1
symbol: bath-41
gene_biotype: protein_coding
description:
  BTB and MATH domain-containing protein 41; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.


ensembl_gene_id: F37B12.2.1
symbol: gcs-1
gene_biotype: protein_coding
description:
  Glutamate--cysteine ligase; Plays a role in resistance to arsenite. May play a role in the oxidative stress response induced by reactive oxygen species produced during infection by pathogenic bacteria. Together with trxr-1, required for the reduction of disulfide groups in the cuticle during molting.


ensembl_gene_id: F37B4.2.1
symbol: ifc-1
gene_biotype: protein_coding
description:
  Intermediate filament protein ifc-1; Cytoplasmic intermediate filaments provide mechanical strength to cells. Not essential protein.


ensembl_gene_id: F37B4.7.1
symbol: folt-2
gene_biotype: protein_coding
description:
  Folate-like transporter 2; Unlike folt-1, does not appear to act as a folate transporter; Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.


ensembl_gene_id: F37C12.2.2
symbol: epg-4
gene_biotype: protein_coding
description:
  Ectopic P granules protein 4; Involved in autophagy. Thought to act in autophagasome and omegasome formation.


ensembl_gene_id: F37C12.4.2
symbol: rpl-36
gene_biotype: protein_coding
description:
  60S ribosomal protein L36; Component of the large ribosomal subunit. Belongs to the eukaryotic ribosomal protein eL36 family.


ensembl_gene_id: F37E3.1.1
symbol: ncbp-1
gene_biotype: protein_coding
description:
  Nuclear cap-binding protein subunit 1; Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi). The CBC complex is involved in miRNA-mediated RNA interference and is required for primary microRNAs (miRNAs) processing. In the CBC complex, ncbp-1 does not bind directly capped RNAs (m7GpppG- capped RNA) but is required to stabilize the movement of the N-terminal loop of ncbp-2 and lock the CBC into a high affinity cap-binding state with the c [...]


ensembl_gene_id: F37F2.2.1
symbol: F37F2.2
gene_biotype: protein_coding
description:
  Probable signal recognition particle 19 kDa protein; Signal-recognition-particle assembly, binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.


ensembl_gene_id: F37H8.1.1
symbol: lir-3
gene_biotype: protein_coding
description:
  Transcription factor lir-3; Positively regulates the RNA polymerase III-associated transcription of small non-coding RNAs.


ensembl_gene_id: F38A5.1a.1
symbol: odr-8
gene_biotype: protein_coding
description:
  Ufm1-specific protease; Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ufm-1, a ubiquitin-like modifier protein bound to a number of target proteins (By similarity). Required, with oct-4, for the localization of a subset of 7 transmembrane domain odorant receptors, including odr-10, to the cilia of olfactory neurons AWA and AWC. Operates in aggregation behavior, and responses to oxygen levels; Belongs to the peptidase C78 family.


ensembl_gene_id: F38A6.1a.1
symbol: pha-4
gene_biotype: protein_coding
description:
  Defective pharyngeal development protein 4; Acts as a transcription factor required for formation of the pharyngeal primordium. Binds to the consensus sequence 5'-T[AG]TT[TG][AG][TC]-3' with variations of the sequence affecting onset of target gene expression. Activates a wide array of pharyngeal genes including ceh-22 and myo-2 and represses ectodermal genes lin-26 and elt-3, ensuring pharyngeal cell fate. Required for recruitment of htz-1 to a subset of pharyngeal promoters to ensure gene activation and also acts synergistically with tbx-2 in pharyngeal development. Acts in the regul [...]


ensembl_gene_id: F38A6.2a.2
symbol: elp-1
gene_biotype: protein_coding
description:
  Echinoderm microtubule-associated protein-like elp-1; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic; Belongs to the WD repeat EMAP family.


ensembl_gene_id: F38A6.3b.1
symbol: hif-1
gene_biotype: protein_coding
description:
  Hypoxia-inducible factor 1; A transcription factor which is a key regulator in various cellular processes; including environment stress resistance (oxygen levels, hydrogen sulfide and cyanide levels and heat), negative regulation of cell apoptosis in ASJ neurons by inhibition of cep-1 via transcriptional activation of tyr-2, resistance/susceptibility to pathogenic bacteria, lifespan and brood size. Involved in mediating susceptibility to enteropathogenic E.coli. Increased levels of hif-1 activity confer resistance to P.aeruginosa-mediated death but also confer susceptibility to S.aureu [...]


ensembl_gene_id: F38B2.1d.1
symbol: ifa-1
gene_biotype: protein_coding
description:
  Intermediate filament protein ifa-1; Cytoplasmic intermediate filaments make up the structural component of the cytoskeleton providing mechanical strength to cells. Essential protein required during embryogenesis especially for survival past the L1 larva stage, involved in intestine morphogenesis.


ensembl_gene_id: F38B2.4a.1
symbol: F38B2.4
gene_biotype: protein_coding
description:
  Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.


ensembl_gene_id: F38B6.4.1
symbol: F38B6.4
gene_biotype: protein_coding
description:
  Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family.  In the central section; belongs to the AIR synthase family.


ensembl_gene_id: F38B6.6.1
symbol: F38B6.6
gene_biotype: protein_coding
description:
  Protein O-mannosyl-transferase TMTC1; Transfers mannosyl residues to the hydroxyl group of serine or threonine residues.


ensembl_gene_id: F38E1.5.1
symbol: gpa-2
gene_biotype: protein_coding
description:
  Guanine nucleotide-binding protein alpha-2 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Involved in behavioral responses to P.aeruginosa by controlling the expression of daf-7, a member of the TGF-beta family, in ASJ sensory neurons. Belongs to the G-alpha family. G(q) subfamily.


ensembl_gene_id: F38E1.7.1
symbol: mom-2
gene_biotype: protein_coding
description:
  Protein mom-2; Ligand for members of the frizzled family of seven transmembrane receptors. Required in embryonic development for endoderm specification and the correct positioning and orientation of the mitotic spindles and division planes in blastomere cells. Involved in cleavage axis determination. Binds to receptor tyrosine kinase cam-1. Together with wnt ligand lin-44, plays a role in controlling vulva precursor cell P7.p lineage orientation during vulva development, probably by acting as a ligand for tyrosine kinase receptor lin-18. May act redundantly with other Wnt ligands such  [...]


ensembl_gene_id: F38E11.5.1
symbol: copb-2
gene_biotype: protein_coding
description:
  Probable coatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity); Belongs to the WD repeat COPB2 family.


ensembl_gene_id: F38E11.7a.1
symbol: wrt-3
gene_biotype: protein_coding
description:
  Warthog protein 3; Intercellular signal essential for a variety of patterning events during development.


ensembl_gene_id: F38H4.9.2
symbol: let-92
gene_biotype: protein_coding
description:
  Serine/threonine-protein phosphatase 2A catalytic subunit; Protein phosphatase which plays an essential role in early embryonic cell division. Probably together with constant regulatory subunit paa-1 and regulatory subunit sur-6, positively regulates centriole duplication by preventing the degradation of sas-5 and kinase zyg-1. In addition, plays a role in the recruitment of sas- 6 and maybe sas-5 to centrioles and may dephosphorylate sas-5 and zyg-1 negative regulator szy-20. During vulva development, may play a role with regulatory subunits paa-1 and sur-6 in the induction of vulva c [...]


ensembl_gene_id: F39B1.1.1
symbol: piki-1
gene_biotype: protein_coding
description:
  Phosphatidylinositol 3-kinase piki-1; Phosphatidylinositol 3-kinase involved in clearance of apoptotic cell corpses by phagosomes. Phagosome maturation requires two sequential and non-overlapping pulses of phosphatidylinositol-3- phosphate (PI3P) on the vesicle surface which mediates recruitment of sortins snx-1 and lst-4 and small GTPases rab-5, rab-2 and rab-7. The first pulse is initiated by piki-1, then maintained by vps-34 which also produces the second pulse. Unlike vps-34, not involved in the formation of PI3P in early endosomes; Belongs to the PI3/PI4-kinase family.


ensembl_gene_id: F39B2.11.1
symbol: mtx-1
gene_biotype: protein_coding
description:
  Metaxin-1 homolog; Involved in transport of proteins into the mitochondrion. Essential for embryonic development (By similarity); Belongs to the metaxin family.


ensembl_gene_id: F39B2.2.1
symbol: uev-1
gene_biotype: protein_coding
description:
  Ubiquitin-conjugating enzyme E2 variant 1; Involved in protein ubiquitination, but has no ubiquitin ligase activity on its own. The uev-1-ubc-13 heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. Involved in sorting Lys-63-linked polyubiquitinated maternal membrane proteins for degradation by targeting to multivesicular bodies. Required for glr-1-containing glutamate receptor trafficking in neurons. May have a role in synaptic transmission at motorneurons. May be involved in the ubiquitination and growth of intracellular polygluta [...]


ensembl_gene_id: F39B2.4b.1
symbol: sur-2
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 23; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors (By similarity). Functi [...]


ensembl_gene_id: F39B2.7.1
symbol: mtcu-1
gene_biotype: protein_coding
description:
  TrmE-type G domain-containing protein; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.


ensembl_gene_id: F39C12.2b.1
symbol: add-1
gene_biotype: protein_coding
description:
  Adducin-related protein 1; Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network.


ensembl_gene_id: F39C12.3b.1
symbol: tsp-14
gene_biotype: protein_coding
description:
  Tetraspanin-14; Together with tsp-12, regulates cell fate specification in the postembryonic mesodermal M lineage, body size and male development, probably by positively modulating BMP-like Sma/Mab signaling. Together with tsp-12, probably acts by modulating the activation of glp-1, Notch-like receptor, to regulate germline maturation ; Belongs to the tetraspanin (TM4SF) family.


ensembl_gene_id: F39C12.4.1
symbol: ntc-1
gene_biotype: protein_coding
description:
  Nematocin; Ligand for the G-protein coupled receptor ntr-1. Plays a role in gustatory associative learning. Also plays a role in male mating behavior.


ensembl_gene_id: F39H11.3.1
symbol: cdk-8
gene_biotype: protein_coding
description:
  Cyclin-dependent kinase 8; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C- terminal domain) of the l [...]


ensembl_gene_id: F39H2.1.1
symbol: flp-22
gene_biotype: protein_coding
description:
  FMRFamide-like neuropeptides 22; FMRFamides and FMRFamide-like peptides are neuropeptides. Belongs to the FARP (FMRFamide related peptide) family.


ensembl_gene_id: F39H2.2a.2
symbol: sig-7
gene_biotype: protein_coding
description:
  Peptidyl-prolyl cis-trans isomerase sig-7; Probable PPIase that accelerates the folding of proteins (By similarity). It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Involved in RNA polymerase II (RNA pol II)-mediated transcription elongation, and in primary transcript splicing, including co-transcriptional trans- splicing, in association with the catalytic subunit of the RNA pol II complex ama-1. Also plays a role in the regulation of elongation-dependent phosphorylation of ama-1 to control transcription. Involved in the transc [...]


ensembl_gene_id: F40A3.5.1
symbol: nipi-4
gene_biotype: protein_coding
description:
  Protein nipi-4; Pseudokinase which plays a role in resistance to fungal infection by promoting expression of antimicrobial peptides (nlp-29, nlp-31, nlp-34, cnc-1, cnc-2 and cnc-4) in the epidermis. In addition, up-regulates nlp-29 expression upon physical wounding and in response to phorbol ester PMA treatment; Belongs to the protein kinase superfamily. Tyr protein kinase family.


ensembl_gene_id: F40B5.2a.1
symbol: F40B5.2
gene_biotype: protein_coding
description:
  Putative metallophosphoesterase F40B5.2; Belongs to the metallophosphoesterase superfamily. LOC643853 family.


ensembl_gene_id: F40E10.1.1
symbol: hch-1
gene_biotype: protein_coding
description:
  Zinc metalloproteinase nas-34; Metalloprotease (By similarity). Required for normal hatching and migration of neuroblasts. May act by degrading eggshell proteins at hatching.


ensembl_gene_id: F40E10.3.1
symbol: csq-1
gene_biotype: protein_coding
description:
  Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.


ensembl_gene_id: F40E10.4.1
symbol: slt-1
gene_biotype: protein_coding
description:
  Slit homolog 1 protein; Functions as a ligand for sax-3 receptor during larval development. Acts via the sax-3/Robo receptor to direct ventral axon guidance and guidance at the midline during embryonic development.


ensembl_gene_id: F40F11.2.1
symbol: mig-38
gene_biotype: protein_coding
description:
  Abnormal cell migration protein 38; During gonad development, involved in distal tip cell (DTC) migration from the dorsal side of the hermaphrodite body to the midbody which allows for the formation of gonad arms. Role in gonad DTC migration may be in association with integrin related proteins ina-1 and mig-15.


ensembl_gene_id: F40F4.2.1
symbol: lbp-2
gene_biotype: protein_coding
description:
  Fatty acid-binding protein homolog 2; May play a role in sequestering potentially toxic fatty acids and their peroxidation products, or it may be involved in the maintenance of the impermeable lipid layer of the eggshell.


ensembl_gene_id: F40F4.3.2
symbol: lbp-1
gene_biotype: protein_coding
description:
  Fatty acid-binding protein homolog 1; May play a role in sequestering potentially toxic fatty acids and their peroxidation products, or it may be involved in the maintenance of the impermeable lipid layer of the eggshell. Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.


ensembl_gene_id: F40F4.4a.1
symbol: lbp-3
gene_biotype: protein_coding
description:
  Fatty acid-binding protein homolog 3; May play a role in sequestering potentially toxic fatty acids and their peroxidation products, or it may be involved in the maintenance of the impermeable lipid layer of the eggshell. Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.


ensembl_gene_id: F40F4.6b.1
symbol: irg-7
gene_biotype: protein_coding
description:
  Protein irg-7; Plays a role in innate immunity, probably via the atf-7 pathway, to confer resistance to pathogenic bacteria. May also play a role in the regulation of longevity.


ensembl_gene_id: F40F8.1b.1
symbol: F40F8.1
gene_biotype: protein_coding
description:
  UMP-CMP kinase 2; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.


ensembl_gene_id: F40F8.9.2
symbol: lsm-1
gene_biotype: protein_coding
description:
  U6 snRNA-associated Sm-like protein LSm1; Probably involved with other LSm subunits in the general process of degradation of mRNAs.


ensembl_gene_id: F40G9.1.1
symbol: sec-20
gene_biotype: protein_coding
description:
  Yeast SEC homolog; Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.


ensembl_gene_id: F41C3.4.1
symbol: eas-1
gene_biotype: protein_coding
description:
  Probable Golgi transport protein 1; May be involved in fusion of ER-derived transport vesicles with the Golgi complex; Belongs to the GOT1 family.


ensembl_gene_id: F41C6.1.1
symbol: unc-6
gene_biotype: protein_coding
description:
  Netrin unc-6; Component of an extracellular matrix cue that guides dorsoventral migrations on the epidermis. Required for the guidance of pioneer axons and migrating cells along the body wall. During gonad morphogenesis, involved in distal tip cell (DTC) migration from the dorsal side of the hermaphrodite body to the midbody to allow for formation of gonad arms. Its association with either unc-40 or unc-5 receptors will lead to axon attraction or repulsion, respectively. Involved in the positioning of ray 1, the most anterior ray sensilium, in the male tail. Required for the formation  [...]


ensembl_gene_id: F41E6.13a.1
symbol: atg-18
gene_biotype: protein_coding
description:
  Autophagy-related protein 18; Component of the autophagy machinery that is recruited to phosphatidylinositols on preautophagosomal structures, which are early autophagic structures, to promote autophagosome formation, and the subsequent degradation and clearance of engulfed apoptotic cells and P- granules in somatic cells. In particular, binds with high affinity to phosphatidylinositols including phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 5-phosphate (PtdIns(5)P), and more weakly to phosphatidylinositol 3,5-bis [...]


ensembl_gene_id: F41F3.2.1
symbol: soc-1
gene_biotype: protein_coding
description:
  Multisubstrate adapter protein soc-1; Adapter protein which modulates signaling mediated by several receptor tyrosine kinases. Plays a role in fluid homeostasis, probably downstream of receptor egl-15 and upstream of let-60/Ras. Involved in nicotinic acetylcholine receptor (nAChR)-mediated sensitivity to nicotine and levamisole and gamma- aminobutyric acid (GABA)receptor-mediated sensitivity to muscimol. Regulates synaptic levels of nAchR receptor subunit lev-1 and unc-38, and GABA receptor subunit unc-49 in the nerve cord, probably downstream of egl-15. Regulates motility. During the  [...]


ensembl_gene_id: F41H10.6c.1
symbol: hda-6
gene_biotype: protein_coding
description:
  Histone deacetylase 6; Probable histone deacetylase. Histone deacetylases are responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity).


ensembl_gene_id: F41H10.7.2
symbol: elo-5
gene_biotype: protein_coding
description:
  Elongation of very long chain fatty acids protein 5; Condensing enzyme that elongates saturated and monounsaturated very long chain fatty acids (VLCFAs) and monomethyl branched-chain fatty acids (mmBCFAs). Required for the formation of isopentadecanoate (C15iso) and isoheptadecanoate (C17iso). Belongs to the ELO family.


ensembl_gene_id: F41H10.8.1
symbol: elo-6
gene_biotype: protein_coding
description:
  Elongation of very long chain fatty acids protein 6; Condensing enzyme that elongates saturated and monounsaturated very long chain fatty acids (VLCFAs) and monomethyl branched-chain fatty acids (mmBCFAs). Required for the formation of isoheptadecanoate (C17iso).


ensembl_gene_id: F42A10.4a.1
symbol: efk-1
gene_biotype: protein_coding
description:
  Eukaryotic elongation factor 2 kinase; Phosphorylates 2 adjacent threonine residues, 'Thr-57' and 'Thr-59', in the N-terminus of eukaryotic elongation factor-2.


ensembl_gene_id: F42A6.7d.2
symbol: hrp-1
gene_biotype: protein_coding
description:
  Heterogeneous nuclear ribonucleoprotein A1; This protein is a component of ribonucleosomes. Overexpression gradually increases telomere length, leading to increase lifespan.


ensembl_gene_id: F42A8.2.2
symbol: sdhb-1
gene_biotype: protein_coding
description:
  Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).


ensembl_gene_id: F42A8.3.1
symbol: cup-15
gene_biotype: protein_coding
description:
  Coelomocyte uptake defective protein 15; Modulates the transport of substances from the endosomal to lysosomal compartments. Plays a role in lysosome formation and function in coelomocytes.


ensembl_gene_id: F42A9.2.1
symbol: lin-49
gene_biotype: protein_coding
description:
  Protein lin-49; Essential protein required to maintain expression of homeotic genes egl-5 and mab-5. May play an analogous role to the trithorax Group (trxG) proteins. TrxG proteins form multiprotein complexes that are required to maintain the transcriptionally active state of homeotic genes throughout development. May act via a modification of chromatin.


ensembl_gene_id: F42D1.2.1
symbol: tatn-1
gene_biotype: protein_coding
description:
  Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate.


ensembl_gene_id: F42D1.3.2
symbol: sprr-2
gene_biotype: protein_coding
description:
  Sex peptide receptor-related protein 2; G-protein coupled receptor for the neuropeptide like protein nlp-38. Plays a role in several types of aversive gustatory associative learning including gustatory plasticity and salt avoidance learning. Its role in salt avoidance learning may be through activation of the transcription factor crh- 1/CREB and de novo transcription and translation, which in turn promotes the formation of long-term memory.


ensembl_gene_id: F42E11.4.1
symbol: tni-1
gene_biotype: protein_coding
description:
  Troponin I 1; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to muscle actomyosin ATPase activity.


ensembl_gene_id: F42F12.2.1
symbol: zig-2
gene_biotype: protein_coding
description:
  Zwei Ig domain protein zig-2; Probably not involved in maintaining the position of ASI and ASH head neuron cell bodies and ventral nerve cord axons of PVQ, PVP, RMEV, AVK and HSN neurons.


ensembl_gene_id: F42F12.4.2
symbol: F42F12.4
gene_biotype: protein_coding
description:
  1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).


ensembl_gene_id: F42G10.2.1
symbol: mkk-4
gene_biotype: protein_coding
description:
  MAP kinase kinase mkk-4; Activity is required in presynaptic neurons, in a dose- dependent manner, for normal presynaptic development and morphology. Plays a role in the formation of muscle connections, also called muscle arm extensions, between the body wall and the motor axons in the dorsal and ventral cord.


ensembl_gene_id: F42G4.3e.2
symbol: zyx-1
gene_biotype: protein_coding
description:
  Zyxin; Functions as both a mechanical stabilizer (via LIM domains) of focal adhesions and as a sensor component for muscle cell damage (via N-terminus). Regulates, stabilizes and maintains posterior lateral mechanosensory (PLM) synaptic branch extension and new synapse formation and growth during larval development.


ensembl_gene_id: F42G8.12.1
symbol: isp-1
gene_biotype: protein_coding
description:
  Cytochrome b-c1 complex subunit Rieske, mitochondrial; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.


ensembl_gene_id: F42G8.3a.1
symbol: pmk-2
gene_biotype: protein_coding
description:
  Mitogen-activated protein kinase pmk-2; Responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating downstream targets.


ensembl_gene_id: F42G8.4a.1
symbol: pmk-3
gene_biotype: protein_coding
description:
  Mitogen-activated protein kinase pmk-3; Responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating downstream targets. Involved in axon regeneration after injury, probably downstream of dlk-1 and mkk-4 and upstream of mak-2. May phosphorylate mak-2. Plays a role in cilium length regulation, possibly by reducing rab-5 mediated endocytosis. Plays a role in the formation of muscle connections, also called muscle arm extensions, between the body wall and the motor axons in the dorsal and ventral cord.


ensembl_gene_id: F42G8.6.1
symbol: moc-3
gene_biotype: protein_coding
description:
  Adenylyltransferase and sulfurtransferase MOCS3; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl- adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (- COSH) of their C-terminus. The reaction probably involves hydrogen sulfide [...]


ensembl_gene_id: F42G9.2.2
symbol: cyn-6
gene_biotype: protein_coding
description:
  Peptidyl-prolyl cis-trans isomerase 6; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.


ensembl_gene_id: F42G9.7.1
symbol: snt-2
gene_biotype: protein_coding
description:
  Synaptotagmin 2; Ca(2+) sensor involved in Ca(2+)-dependent secretion of the nlp-40 neuropeptide from intestinal cells. Involved in the defecation motor program, which is a coordinated series of three muscle contractions that occurs every 45 seconds.


ensembl_gene_id: F42G9.8.1
symbol: tpst-2
gene_biotype: protein_coding
description:
  Putative protein-tyrosine sulfotransferase; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate; Belongs to the protein sulfotransferase family.


ensembl_gene_id: F42H10.5a.2
symbol: mig-39
gene_biotype: protein_coding
description:
  Zinc finger BED domain-containing protein 39; Regulates the timing and orientation of distal tip cell migration during gonadal development. May act in parallel to cacn-1 and Rac GTPases to control the anterior and posterior migration of distal tip cells.


ensembl_gene_id: F42H11.2.1
symbol: lem-3
gene_biotype: protein_coding
description:
  Ankyrin repeat and LEM domain-containing protein 1 homolog; Endonuclease which, in association with baf-1, plays an essential role during embryogenesis in the DNA repair response following DNA damage probably by ensuring proper chromosome segregation. Also required during postembryonic cell divisions after DNA damage caused by ionizing radiation to ensure normal cell proliferation. Resolves chromatin bridges in late mitosis that result from incomplete DNA replication, defective chromosome condensation or unresolved recombination intermediates. Together with brc-1, contributes to genome [...]


ensembl_gene_id: F43C1.2b.1
symbol: mpk-1
gene_biotype: protein_coding
description:
  Mitogen-activated protein kinase mpk-1; Function in let-60 Ras signaling pathway; acts downstream of lin-45 raf kinase, but before the lin-1 gene product in controlling vulval cell differentiation. Plays a negative role in proximal germline proliferation in the mitotic zone. Required for progression of developing oocytes through the pachytene stage. In oocytes, inhibits the activity of the chloride channel clh-3, likely by activating gck-3. Plays a role in response to M.nematophilum-mediated bacterial infection by promoting tail swelling and preventing constipation. Involved in fluid h [...]


ensembl_gene_id: F43C9.4a.2
symbol: mig-13
gene_biotype: protein_coding
description:
  Abnormal cell migration protein 13; Probable receptor that acts as an upstream signaling protein to promote the guidance, migration and positioning of the right Q neuroblast (QR) and its descendants along the anteroposterior body axis, and also the anterior migration of BDU interneurons during larval development. Associates with and recruits the downstream components tyrosine kinase abl-1 and the tyrosine kinase adapter protein sem-5 to the leading edge of migrating Q neuroblasts and their descendants to activate signaling through the two parallel wve-1 and wsp-1 pathways, respectively [...]


ensembl_gene_id: F43D9.6.1
symbol: urm-1
gene_biotype: protein_coding
description:
  Ubiquitin-related modifier 1 homolog; Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress spec [...]


ensembl_gene_id: F43E2.8a.2
symbol: hsp-4
gene_biotype: protein_coding
description:
  Endoplasmic reticulum chaperone BiP homolog; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Required for ER dynamics during the first embryonic cell divisions. Specifically, controls ER transition into sheet-like structures at the onset of mitosis, possibly by regulating homotypic membrane fusion. Belongs to the heat shock protein 70 family.


ensembl_gene_id: F43G6.9.1
symbol: patr-1
gene_biotype: protein_coding
description:
  Protein PAT1 homolog 1; RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery (By similarity); Belongs to the PAT1 family.


ensembl_gene_id: F43G9.1.2
symbol: idha-1
gene_biotype: protein_coding
description:
  Probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial; Belongs to the isocitrate and isopropylmalate dehydrogenases family.


ensembl_gene_id: F43G9.5.1
symbol: cfim-1
gene_biotype: protein_coding
description:
  Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The  [...]


ensembl_gene_id: F43G9.6a.1
symbol: fer-1
gene_biotype: protein_coding
description:
  Sperm vesicle fusion protein fer-1; Required for the fusion of the membranous organelles (MOs) with the plasma membrane, a process essential in spermiogenesis.


ensembl_gene_id: F43H9.2b.1
symbol: sptl-2
gene_biotype: protein_coding
description:
  Serine palmitoyltransferase 2; Component of the serine palmitoyltransferase (SPT) that catalyzes the first committed step in sphingolipid biosynthesis, which is the condensation of an acyl-CoA species and L-serine. The catalytic core is composed of a heterodimer of sptl-1 and sptl-2 or sptl-1 and sptl-3 (By similarity). Required for the specification of abicobasal polarity and development of the gut lumen; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.


ensembl_gene_id: F44A6.2.2
symbol: sex-1
gene_biotype: protein_coding
description:
  Steroid hormone receptor family member cnr14; Belongs to the nuclear hormone receptor family. NR1 subfamily.


ensembl_gene_id: F44B9.1a.2
symbol: dpf-6
gene_biotype: protein_coding
description:
  Dipeptidyl peptidase family member 6; Removes N-terminal dipeptides sequentially from polypeptides (By similarity). Essential for control of distal tip cell migration.


ensembl_gene_id: F44B9.3a.1
symbol: cit-1.2
gene_biotype: protein_coding
description:
  Cyclin-T1.2; Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy- terminal domain) of the large subunit of RNA polymerase II (RNAP II).


ensembl_gene_id: F44B9.4a.1
symbol: cit-1.1
gene_biotype: protein_coding
description:
  Cyclin-T1.1; Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy- terminal domain) of the large subunit of RNA polymerase II (RNAP II).


ensembl_gene_id: F44B9.6.1
symbol: lin-36
gene_biotype: protein_coding
description:
  Protein lin-36; Required to negatively regulate vulval development. Antagonizes Ras-mediated vulval induction. Acts cell autonomously.


ensembl_gene_id: F44B9.8.1
symbol: F44B9.8
gene_biotype: protein_coding
description:
  Probable replication factor C subunit 5; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1.


ensembl_gene_id: F44C4.3.1
symbol: cpr-4
gene_biotype: protein_coding
description:
  Cathepsin B-like cysteine proteinase 4; Thiol protease which shows activity against the fluorogenic substrate z-Arg-Arg-AMC; Belongs to the peptidase C1 family.


ensembl_gene_id: F44C4.5.1
symbol: ppt-1
gene_biotype: protein_coding
description:
  Palmitoyl-protein thioesterase 1; Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides.


ensembl_gene_id: F44C8.11.1
symbol: nhr-96
gene_biotype: protein_coding
description:
  Nuclear hormone receptor family member nhr-96; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family.


ensembl_gene_id: F44C8.2.2
symbol: nhr-134
gene_biotype: protein_coding
description:
  Nuclear hormone receptor family member nhr-134; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family.


ensembl_gene_id: F44C8.3.1
symbol: nhr-18
gene_biotype: protein_coding
description:
  Nuclear hormone receptor family member nhr-18; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family.


ensembl_gene_id: F44C8.4.1
symbol: nhr-103
gene_biotype: protein_coding
description:
  Nuclear hormone receptor family member nhr-103; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family.


ensembl_gene_id: F44C8.8a.1
symbol: nhr-133
gene_biotype: protein_coding
description:
  Nuclear hormone receptor family member nhr-133; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family.


ensembl_gene_id: F44F4.13.1
symbol: sra-11
gene_biotype: protein_coding
description:
  Serpentine receptor class alpha-11; A G protein-coupled receptor required for olfactory imprinting a requisite in ordorant response such as benzaldehyde and isoamylalcohol; Belongs to the nematode receptor-like protein sra family.


ensembl_gene_id: F44F4.2.2
symbol: egg-3
gene_biotype: protein_coding
description:
  Protein tyrosine phosphatase-like protein egg-3; Probable pseudophosphatase required for the oocyte-to-zygote transition during which it regulates the polarized dispersal of the cortical actin cytoskeleton, the synthesis of the eggshell chitin layer and the formation of the polar bodies after meiosis I and II. Acts as scaffold to tether kinase mbk-2 and pseudophosphatases egg-4 and egg-5 to the oocyte cortex and thus restricts mbk-2 activity to the cortex during meiosis I. Regulates mbk-2 localization to cytoplasmic foci during meiosis II. Also required for chitin synthase chs-1 locali [...]


ensembl_gene_id: F44G4.2.1
symbol: F44G4.2
gene_biotype: protein_coding
description:
  Probable NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).


ensembl_gene_id: F44G4.4c.1
symbol: tdp-1
gene_biotype: protein_coding
description:
  Tar DNA-binding protein homolog 1; RNA-binding protein which regulates transcription, splicing and RNA-editing. Limits the accumulation of double- stranded RNA by maintaining the abundance of the mature RNA transcripts that are formed from double-stranded precursor RNAs. Stress response protein that acts downstream of daf-16 in the insulin/IGF pathway to regulate longevity and the cellular stress response to osmotic, oxidative, proteotoxic and endoplasmic reticulum stress. Involved in the regulation of physiological processes including aging, fertility, growth and locomotion.


ensembl_gene_id: F44G4.8a.1
symbol: dep-1
gene_biotype: protein_coding
description:
  Receptor-type tyrosine-protein phosphatase dep-1; Phosphatase which may dephosphorylate receptor let-23 and thereby regulate cell fate during the development of the vulva and the excretory system. By inhibiting let-23 signaling prevents the establishment of a primary cell fate in the descendants of vulva precursor cells P5.p and P7.p. Similarly, may prevent duct cell fate in ABpr precursor. Also dephosphorylates the beta-integrin subunit pat-3, probably within the alpha pat-2/beta pat-3 integrin receptor complex, which leads to down- stream effects including the negative regulation of  [...]


ensembl_gene_id: F45E1.6.1
symbol: his-71
gene_biotype: protein_coding
description:
  Histone H3.3 type 1; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central  [...]


ensembl_gene_id: F45E10.1c.1
symbol: unc-53
gene_biotype: protein_coding
description:
  Adapter protein unc-53; Involved in the migration and outgrowth of muscles, axons and excretory canals.


ensembl_gene_id: F45E12.1b.1
symbol: cnep-1
gene_biotype: protein_coding
description:
  CTD nuclear envelope phosphatase 1 homolog; Serine/threonine protein phosphatase that may dephosphorylate and activate lipin-like phosphatases. Lipins are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol.


ensembl_gene_id: F45E12.3.1
symbol: cul-4
gene_biotype: protein_coding
description:
  Cullin-4; Component of cullin-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. In association with ddb-1 directs ubiquitination of cdt-1 during S phase and is required for restraining DNA rereplication. Probably is involved in ubiquitination of cki-1.


ensembl_gene_id: F45E4.1.1
symbol: arf-1.1
gene_biotype: protein_coding
description:
  ADP-ribosylation factor 1-like 1; GTP-binding protein that may be involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus; Belongs to the small GTPase superfamily. Arf family.


ensembl_gene_id: F45E4.3a.1
symbol: cla-1
gene_biotype: protein_coding
description:
  Protein clarinet; Required for synapse development in the active zone of presynaptic terminals of specific neurons including serotonergic NSM neurons. The active zone is a protein-dense neuronal region within the presynaptic bouton, from which synaptic vesicles send neurotransmitter signals across the synapse. Plays a role in the recruitment and clustering of synaptic vesicles in the active zone of presynaptic terminals in serotonergic NSM neurons, and coordinates the release of synaptic vesicles at presynaptic terminals to regulate neurotransmission at neuromuscular junctions. Regulat [...]


ensembl_gene_id: F45G2.10.1
symbol: F45G2.10
gene_biotype: protein_coding
description:
  MIP18 family protein F45G2.10; May play a role in chromosome segregation through establishment of sister chromatid cohesion; Belongs to the MIP18 family.


ensembl_gene_id: F45G2.2a.1
symbol: myo-6
gene_biotype: protein_coding
description:
  Myosin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.


ensembl_gene_id: F45G2.4.2
symbol: cope-1
gene_biotype: protein_coding
description:
  Coatomer subunit epsilon; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity).


ensembl_gene_id: F45G2.5.1
symbol: bli-5
gene_biotype: protein_coding
description:
  Kunitz-type protein bli-5; Appears to lack serine protease inhibitor activity in vitro when tested with bovine pancreatic alpha-chymotrypsin and elastase. Involved in cuticle biosynthesis.


ensembl_gene_id: F45G2.8.1
symbol: F45G2.8
gene_biotype: protein_coding
description:
  Mitochondrial import inner membrane translocase subunit tim-16; Regulates ATP-dependent protein translocation into the mitochondrial matrix; Belongs to the TIM16/PAM16 family.


ensembl_gene_id: F45G2.9.1
symbol: F45G2.9
gene_biotype: protein_coding
description:
  rRNA methyltransferase 2, mitochondrial; S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methyluridine at position 808 (Um808) in the mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA.


ensembl_gene_id: F45H11.2.1
symbol: ned-8
gene_biotype: protein_coding
description:
  NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex uba-3-ula-1 and linkage to the E2 enzyme ubc-12. Attachment of ned-8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.


ensembl_gene_id: F45H7.4.2
symbol: prk-2
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase prk-2; Involved in the negative regulation of synaptic differentiation in PLM neurons; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. PIM subfamily.


ensembl_gene_id: F45H7.6b.1
symbol: hecw-1
gene_biotype: protein_coding
description:
  E3 ubiquitin-protein ligase hecw-1; E3 ubiquitin-protein ligase (By similarity). Functions in the OLL neurons in the anterior ganglion to inhibit avoidance to microbial pathogens such as P.aeruginosa although worms do display avoidance behavior, vacating a P.aeruginosa lawn within 24 hours. Likely to act by inhibiting the neuropeptide receptor npr-1.


ensembl_gene_id: F46A8.10.1
symbol: scrm-6
gene_biotype: protein_coding
description:
  Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane.


ensembl_gene_id: F46A9.5.4
symbol: skr-1
gene_biotype: protein_coding
description:
  Skp1-related protein; Probable essential component of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates cell proliferation during embryonic and larval development. Involved in synapse elimination in early synapse development. May negatively regulate the apoptotic activity of cep-1 in response to genotoxic stress. Plays a role in sex determination.


ensembl_gene_id: F46C3.1.1
symbol: pek-1
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 2-alpha kinase pek-1; Phosphorylates the alpha subunit of eukaryotic translation- initiation factor 2 (eIF2alpha), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. May phosphorylate eIF2alpha during hypoxia. Proposed to have a role in alleviating endoplasmic reticulum stress ; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.


ensembl_gene_id: F46C5.8.1
symbol: rer-1
gene_biotype: protein_coding
description:
  Protein RER1 homolog; May be involved in protein transport along the secretory pathway; Belongs to the RER1 family.


ensembl_gene_id: F46C8.5.1
symbol: ceh-14
gene_biotype: protein_coding
description:
  Homeobox protein ceh-14; Confers thermosensory function to neurons. Required for correct AFD-mediated thermotaxis.


ensembl_gene_id: F46C8.6.1
symbol: dpy-7
gene_biotype: protein_coding
description:
  Cuticle collagen dpy-7; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Mutations in dpy-7 affects the body shape.


ensembl_gene_id: F46F11.1a.1
symbol: F46F11.1
gene_biotype: protein_coding
description:
  Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis- diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2- InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to p [...]


ensembl_gene_id: F46F11.5.2
symbol: vha-10
gene_biotype: protein_coding
description:
  Probable V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.


ensembl_gene_id: F46F2.2c.2
symbol: kin-20
gene_biotype: protein_coding
description:
  Casein kinase I isoform delta; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity). Is a developmental timer that specifies temporal cell fate selection; acts to control the temporal identity of hypodermal seam cells. Required during late-larval development to prevent adult fates, particularly cell cycle exit and fusion, from being expressed too early.


ensembl_gene_id: F46F6.4a.1
symbol: dyf-6
gene_biotype: protein_coding
description:
  Intraflagellar transport protein 46 homolog; Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. May be required for ciliary entrance and transport of specific ciliary cargo proteins such as che-3 which are related to motility. Required for normal morphology and function of ciliated amphid sensory neurons.


ensembl_gene_id: F46G10.3.1
symbol: sir-2.3
gene_biotype: protein_coding
description:
  NAD-dependent protein deacylase sir-2.3; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues. Plays a role in oxidative stress resistance. Might promote neuronal cell death under ischemic conditions and cell death in touch neurons induced by mec-4 channel hyperactivation, possibly downstream of the insulin-like receptor daf-2. Might attenuate the reactive oxygen species (ROS) scavenging system, that eliminates ROS in ischemic conditions, under dietary deprivation and when glycolysis is blocked ; Belongs to the sirtuin family. Clas [...]


ensembl_gene_id: F46G10.7c.1
symbol: sir-2.2
gene_biotype: protein_coding
description:
  NAD-dependent protein deacylase sir-2.2; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues. Plays a role in oxidative stress resistance.


ensembl_gene_id: F46H6.1.1
symbol: rhi-1
gene_biotype: protein_coding
description:
  Probable rho GDP-dissociation inhibitor; Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.


ensembl_gene_id: F47A4.2.1
symbol: dpy-22
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 12; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Functio [...]


ensembl_gene_id: F47A4.3a.1
symbol: rrc-1
gene_biotype: protein_coding
description:
  GTPase-activating protein rrc-1; Functions as a GTPase-activating protein (GAP) for ced- 10/rac-1 and CDC42.


ensembl_gene_id: F47B10.1.1
symbol: suca-1
gene_biotype: protein_coding
description:
  Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.


ensembl_gene_id: F47B10.7.1
symbol: acbp-3
gene_biotype: protein_coding
description:
  Acyl-CoA-binding protein homolog 3; Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters.


ensembl_gene_id: F47D12.1c.1
symbol: gar-2
gene_biotype: protein_coding
description:
  Muscarinic acetylcholine receptor gar-2; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover (By similarity). Regulates the activity of ventral cord motor neurons. Couples to the G(o) alpha G-protein subunit goa-1 to negatively regulate cholinergic receptor activity in the presence of high levels of the neurotransmitter acetylcholine in ventral cord motor neurons. As acetylcholin [...]


ensembl_gene_id: F47F2.1b.1
symbol: F47F2.1
gene_biotype: protein_coding
description:
  cAMP-dependent protein kinase, catalytic subunit-like; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. cAMP subfamily.


ensembl_gene_id: F47F6.1d.1
symbol: lin-42
gene_biotype: protein_coding
description:
  Period protein homolog lin-42; Transcriptional repressor which interacts with the promoter region of target genes. Has a specific role in developmental timing where it regulates temporal expression of a number of miRNAs and mRNAs. Controls temporal cell fate transition during embryonic and early larval development by restricting the expression of specific miRNAs, including let-7, miR-48, lin-4, miR-35 and miR-58. Restricts the accumulation of lin-29 in the hypodermis to the larval L4 stage, thus controlling terminal differentiation of seam cells. Has a role in the miRNA-mediated specif [...]


ensembl_gene_id: F47G4.7.1
symbol: smd-1
gene_biotype: protein_coding
description:
  S-adenosylmethionine decarboxylase alpha chain; Essential for biosynthesis of the polyamines spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.


ensembl_gene_id: F47G6.1a.1
symbol: dyb-1
gene_biotype: protein_coding
description:
  Dystrobrevin-1; Plays a role in cholinergic transmission and as a functional partner of dystrophin (dys-1), necessary for muscle maintenance.


ensembl_gene_id: F48A11.1c.1
symbol: chs-2
gene_biotype: protein_coding
description:
  Chitin synthase chs-2; May be involved in chitin synthesis in the pharynx during larval development; Belongs to the chitin synthase family. Class IV subfamily.


ensembl_gene_id: F48A11.5a.1
symbol: ubxn-3
gene_biotype: protein_coding
description:
  UBX domain-containing protein 3; Ubiquitin-binding protein which acts as an adapter for ATPase cdc-48.1 and/or cdc-48.2, conferring substrate specificity. Together with ubxn-1 and ubxn-2, plays a role in hermaphrodite spermatogenesis probably by promoting the degradation of sex determination terminal factor tra-1. During mitosis, ensures the degradation of DNA licensing factor cdt-1 and the disassembly of the DNA replication CMG helicase complex by promoting the dissociation from chromatin of several of its components including cdc-45 and sld-5.


ensembl_gene_id: F48C1.7.1
symbol: spe-11
gene_biotype: protein_coding
description:
  Spermatocyte protein spe-11; Paternally sperm-supplied factor required for embryogenesis. Plays a role in preventing polyspermy possibly by promoting the formation of a continuous and cohesive eggshell chitin layer.


ensembl_gene_id: F48C11.1.1
symbol: gpa-6
gene_biotype: protein_coding
description:
  Guanine nucleotide-binding protein alpha-6 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems; Belongs to the G-alpha family.


ensembl_gene_id: F48D6.3.1
symbol: hlh-13
gene_biotype: protein_coding
description:
  Helix-loop-helix protein 13; Transcriptional activator (By similarity). Shown to have a role in the negative regulation of exit from L1 arrest and dauer diapause dependent on IIS signaling (insulin and insulin-like growth factor (IGF) signaling). Hypodermal expression is regulated by IIS/daf- 16 while neuronal expression is not under the control of IIS/daf-16.


ensembl_gene_id: F48E3.7.1
symbol: lgc-11
gene_biotype: protein_coding
description:
  Acetylcholine receptor (51.1 kD) (Acr-22); Belongs to the ligand-gated ion channel (TC 1.A.9) family.


ensembl_gene_id: F48E8.1a.1
symbol: lon-1
gene_biotype: protein_coding
description:
  Protein lon-1; Regulates body size morphogenesis, but does not affect male tail development; Belongs to the CRISP family.


ensembl_gene_id: F48E8.5.2
symbol: paa-1
gene_biotype: protein_coding
description:
  Probable serine/threonine-protein phosphatase PP2A regulatory subunit; Acts as a scaffolding protein for phosphatase let-92 and its regulatory subunits (Probable). Probably together with let-92 and regulatory subunit sur-6, regulates centriole duplication, microtubule outgrowth and mitotic spindle stability during early embryonic cell division by preventing the degradation of sas-5 and kinase zyg-1. During vulva development, may play a role with phosphatase let-92 and regulatory subunit sur-6 in the induction of vulva cell precursors by positively regulating let-60/Ras- MAP kinase sign [...]


ensembl_gene_id: F48E8.6.1
symbol: disl-2
gene_biotype: protein_coding
description:
  DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'.


ensembl_gene_id: F48F5.5.1
symbol: fce-2
gene_biotype: protein_coding
description:
  CAAX prenyl protease 2 homolog; Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins; Belongs to the peptidase U48 family.


ensembl_gene_id: F48F7.2.2
symbol: syx-2
gene_biotype: protein_coding
description:
  Putative syntaxin-2; Potentially involved in docking of synaptic vesicles at presynaptic active zones; Belongs to the syntaxin family.


ensembl_gene_id: F49B2.5.1
symbol: src-2
gene_biotype: protein_coding
description:
  Tyrosine protein-kinase src-2; Non-receptor tyrosine-protein kinase which may play a role in larval and pharynx development. Unlike src-1, does not play a role in embryonic development.


ensembl_gene_id: F49C12.13.1
symbol: vha-17
gene_biotype: protein_coding
description:
  V-type proton ATPase subunit e; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.


ensembl_gene_id: F49C12.8.1
symbol: rpn-7
gene_biotype: protein_coding
description:
  26S proteasome non-ATPase regulatory subunit 6; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.


ensembl_gene_id: F49E10.3.1
symbol: flp-7
gene_biotype: protein_coding
description:
  FMRFamide-like neuropeptides 7; FMRFamides and FMRFamide-like peptides are neuropeptides. flp-7 stimulates serotonin-induced fat loss by binding to and activating the npr-22 receptor which leads to induction of the atgl-1 lipase and subsequent fat loss. SPMQRSSMVRF-amide: Acts as a ligand for the npr-22 receptor in vitro. [SPMDRSKMVRF-amide]: Acts as a ligand for the npr-22 receptor in vitro.


ensembl_gene_id: F49E10.5a.1
symbol: ctbp-1
gene_biotype: protein_coding
description:
  C-terminal-binding protein 1; Binds DNA and represses gene expression. Plays a role in regulation of life span, possibly by regulating transcription of genes important for lipid metabolism.


ensembl_gene_id: F49E11.1b.1
symbol: mbk-2
gene_biotype: protein_coding
description:
  Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2; Required for oocyte-to-zygote transition in which it phosphorylates oocyte proteins, including mei-1, oma-1, oma-2, mex-5, and mex-6, modifying their activity and/or stability following meiosis. Functions in both spindle positioning and in the posterior localization of cytoplasmic determinants, including pie-1, pos-1, and pgl-1, in early embryos. Involved in the asymmetric distribution of plk-1 at the 2-cell embryonic stage.


ensembl_gene_id: F49E11.3.1
symbol: amt-2
gene_biotype: protein_coding
description:
  Putative ammonium transporter 2; Involved in the uptake of ammonia (Probable). Implicated in aging; Belongs to the ammonia transporter channel (TC 1.A.11.2) family.


ensembl_gene_id: F49E12.1.1
symbol: skpo-1
gene_biotype: protein_coding
description:
  Peroxidase skpo-1; Involved in hypodermal immune response against some types of bacterial infection. Probably utilizes H(2)O(2) produced by the NADPH oxidase bli-3. May play a role in cuticule biosynthesis. Belongs to the peroxidase family. XPO subfamily.


ensembl_gene_id: F49E12.5a.1
symbol: sra-13
gene_biotype: protein_coding
description:
  Serpentine receptor class alpha-13; Chemosensory receptor that negatively regulates RAS/MAPK signaling during vulva induction and the negative regulation of olfaction of volitile attractants. Required for the suppression of vulval induction in response to food starvation. Signaling acts through the GPA-5 G-alpha protein subunit; Belongs to the nematode receptor-like protein sra family.


ensembl_gene_id: F49E2.1b.1
symbol: F49E2.1
gene_biotype: protein_coding
description:
  Cyclic pyranopterin monophosphate synthase; Isoform mocs1a and isoform mocs1b probably form a complex that catalyzes the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP). mocs1a catalyzes the cyclization of GTP to (8S)- 3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate and mocs1b catalyzes the subsequent conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'- triphosphate to cPMP; In the N-terminal section; belongs to the radical SAM superfamily. MoaA family.


ensembl_gene_id: F49E7.1a.1
symbol: rme-6
gene_biotype: protein_coding
description:
  Receptor-mediated endocytosis protein 6; Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in endocytosis. Acts by regulating the activation of rab-5 by exchanging bound GDP for free GTP at clathrin coated pits.


ensembl_gene_id: F49E8.3b.1
symbol: pam-1
gene_biotype: protein_coding
description:
  Puromycin-sensitive aminopeptidase; Aminopeptidase. Required for the exit from meiosis, probably upstream of cyclin cyb-3. Involved in the establishment of the anterior-posterior polarity at the embryonic 1-cell stage by regulating the dynamics of sperm-donated centrosomes. Plays a role in oocyte maturation. Required for embryonic development. Belongs to the peptidase M1 family.


ensembl_gene_id: F49E8.4.1
symbol: cdd-2
gene_biotype: protein_coding
description:
  Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.


ensembl_gene_id: F49E8.5.3
symbol: dif-1
gene_biotype: protein_coding
description:
  Protein dif-1; Seems to play a role in the maintenance of tissue differentiation in the developing embryo, but not for its initiation.


ensembl_gene_id: F52A8.2a.1
symbol: gpb-2
gene_biotype: protein_coding
description:
  Guanine nucleotide-binding protein subunit beta-2; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.


ensembl_gene_id: F52A8.6a.1
symbol: kbrl-1
gene_biotype: protein_coding
description:
  NF-kappa-B inhibitor-interacting Ras-like protein; Atypical Ras-like protein that may act as a regulator of NF- kappa-B activity.


ensembl_gene_id: F52B11.2a.1
symbol: F52B11.2
gene_biotype: protein_coding
description:
  Probable phosphomannomutase; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions; Belongs to the eukaryotic PMM family.


ensembl_gene_id: F52B5.5a.2
symbol: cep-1
gene_biotype: protein_coding
description:
  Transcription factor cep-1; Transcriptional activator that binds the same DNA consensus sequence as p53. Has a role in normal development to ensure proper meiotic chromosome segregation. Promotes apoptosis under conditions of cellular and genotoxic stress in response to DNA damage, hypoxia, or starvation. Regulates germline apoptosis in response to DNA damage. Its pro-apoptotic activity is inhibited when bound to ape-1 in vitro. Plays a role in cell cycle arrest in the germline in response to DNA damage by UV-C light. However, not required for survival in response to DNA damage induced [...]


ensembl_gene_id: F52C12.1a.1
symbol: F52C12.1
gene_biotype: protein_coding
description:
  Probable tyrosyl-DNA phosphodiesterase; DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead- end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. May have low 3'exonuclease activity and may be able to remove a sin [...]


ensembl_gene_id: F52C12.2.1
symbol: F52C12.2
gene_biotype: protein_coding
description:
  Probable ribosome biogenesis protein CELE_F52C12.2; Probable pre-rRNA processing protein involved in ribosome biogenesis.


ensembl_gene_id: F52C9.1.1
symbol: sorf-2
gene_biotype: protein_coding
description:
  Suppressor of organelle fusion 2; Together with sorf-1 negatively regulates the levels of phosphatidylinositol 3-phosphate (PtdIns3P) to enable the conversion of early endosomes to late endosomes. Binds to sorf-1 and the sorf-1-sorf- 2 complex likely acts through bec-1, a non-catalytic subunit of phosphatidylinositol 3-kinase (PI3K), to suppress PI3K activity, thereby negatively regulating endosomal PtdIns3P levels. Belongs to the WD repeat WDR81 family.


ensembl_gene_id: F52C9.8b.1
symbol: pqe-1
gene_biotype: protein_coding
description:
  Putative RNA exonuclease pqe-1; Putative RNA exonuclease which protects neurons from the toxic effects of expanded poly-Q disease proteins. It is unknown whether this is via participation in the pathogenic mechanism underlying poly-Q-induced neurodegeneration or if it is by acting as a genetic modifier of the age of onset or progression of neurodegeneration. Regulates gene expression in neurons.


ensembl_gene_id: F52D10.3a.3
symbol: ftt-2
gene_biotype: protein_coding
description:
  14-3-3-like protein 2; Required for extension of life-span by sir-2.1. Promotes nuclear export of yap-1. Negatively regulates the transcriptional activity of daf-16 by sequestering it to the cytoplasm. Belongs to the 14-3-3 family.


ensembl_gene_id: F52E1.10.2
symbol: vha-18
gene_biotype: protein_coding
description:
  Probable V-type proton ATPase subunit H 1; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates the ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (By similarity).


ensembl_gene_id: F52E1.4b.1
symbol: gcy-7
gene_biotype: protein_coding
description:
  Receptor-type guanylate cyclase gcy-7; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Unlike other guanylate cyclases expressed in ASE neurons, may not play a role in chemotaxis responses toward salt ions in ASEL (ASE left) sensory neurons.


ensembl_gene_id: F52E1.9b.1
symbol: F52E1.9
gene_biotype: protein_coding
description:
  Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).


ensembl_gene_id: F52E10.1.1
symbol: sdc-1
gene_biotype: protein_coding
description:
  Zinc finger protein sdc-1; Embryonic transcription factor regulating downstream genes involved specifically in the sex determination and dosage compensation pathways, or regulating other genes involved in the coordinate control of both processes. Component of the SDC complex that functions in sex determination and in X chromosome dosage compensation specifically in hermaphrodite (XX) animals. Involved in the recruitment of the condensin I-like dosage compensation complex to the male sex-determining autosomal gene her-1, thereby contributing to its repression and initiating hermaphrodit [...]


ensembl_gene_id: F52E10.5.1
symbol: ifa-3
gene_biotype: protein_coding
description:
  Intermediate filament protein ifa-3; Cytoplasmic intermediate filaments provide mechanical strength to cells. Essential protein, involved in attachment structures in epidermal cells that connect muscles to the external cuticle. Required for epidermal morphogenesis in embryos. Probable component of embryonic epidermal attachment structures.


ensembl_gene_id: F52E4.7.1
symbol: sec-3
gene_biotype: protein_coding
description:
  Exocyst complex component 1; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.


ensembl_gene_id: F52F12.1a.1
symbol: oct-1
gene_biotype: protein_coding
description:
  Organic cation transporter 1; Transports organic cations such as tetraethylammonium (TEA). Displays a broad substrate specificity.


ensembl_gene_id: F52F12.3.1
symbol: mom-4
gene_biotype: protein_coding
description:
  Mitogen-activated protein kinase kinase kinase mom-4; Part of the Wnt signaling pathway essential for the specification of the mesodermal cell fate in early embryos. Stimulates the wrm-1/lit-1-dependent phosphorylation of pop-1 and plays a role in the initial nuclear accumulation of wrm-1. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.


ensembl_gene_id: F52F12.6a.1
symbol: ztf-11
gene_biotype: protein_coding
description:
  Zinc finger protein ztf-11; Transcriptional repressor which promotes neuronal differentiation during embryonic and postembryonic neurogenesis. Together with components of the MuvB corepressor complex, negatively regulates the expression of non-neuronal genes during neurogenesis. Required for the generation of postembryonic neurons from epidermal cells. Belongs to the MYT1 family.


ensembl_gene_id: F52G2.1b.1
symbol: dcap-2
gene_biotype: protein_coding
description:
  mRNA-decapping enzyme 2; RNA-decapping enzyme although it does not bind cap. May contribute to gene regulation in multiple RNA pathways including monomethylguanosine- and trimethylguanosine-capped RNAs. Belongs to the Nudix hydrolase family. DCP2 subfamily.


ensembl_gene_id: F52H3.1.1
symbol: let-268
gene_biotype: protein_coding
description:
  Multifunctional procollagen lysine hydroxylase and glycosyltransferase; Multifunctional enzyme that catalyzes a series of post- translational modifications on Lys residues in procollagen. Catalyzes the formation of hydroxylysine residues in -Xaa-Lys-Gly- sequences in type IV collagens (By similarity). Transfers galactose onto hydroxylysine groups, giving rise to galactosyl 5- hydroxylysine (By similarity). Catalyzes the subsequent transfer of glucose moieties, giving rise to 1,2-glucosylgalactosyl-5-hydroxylysine residues. Essential for normal biosynthesis and secretion of type IV coll [...]


ensembl_gene_id: F52H3.2.1
symbol: mtcu-2
gene_biotype: protein_coding
description:
  Protein MTO1 homolog, mitochondrial; Involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs. Belongs to the MnmG family.


ensembl_gene_id: F53A2.6a.2
symbol: ife-1
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 4E-1; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. All 5 eIF4E proteins bind monomethyl cap structures. Only ife-1, ife-2 and ife-5 bind trimethyl cap structures which result from trans-splicing. Translation of trimethyl cap structure mRNAs may be regulated by intracellular redox state; disulfide bonds change the width and depth of the cap-binding cavity determining selectivit [...]


ensembl_gene_id: F53A2.8b.2
symbol: mtm-6
gene_biotype: protein_coding
description:
  Myotubularin-related protein 6; May dephosphorylate phosphatidylinositol-3-phosphate (PI3P). In association with mtm-9, plays a role in endosome trafficking probably by regulating phosphatidylinositol-3-phosphate levels. Regulates fluid phase endocytosis in coelomocytes. Controls the endosomal localization of sorting nexin snx-3 and the levels of sorting receptor mig-14. By regulating the retrograde transport of mig-14, may be involved in the secretion of Wnt ligands such as egl-20. Regulates posterior migration of QL neuroblast descendants and the anterior migration of QR neuroblast d [...]


ensembl_gene_id: F53A3.4b.1
symbol: pqn-41
gene_biotype: protein_coding
description:
  Polyglutamine-repeat protein pqn-41; [Isoform d]: In males, required for non-apoptotic death of the linker cell once it has finished guiding gonad elongation at the end of larval development. May be involved in nuclear envelope crenellation in the linker cell. [Isoform b]: In males, promotes linker cell survival.


ensembl_gene_id: F53A9.2.1
symbol: kreg-1
gene_biotype: protein_coding
description:
  Protein kreg-1; Plays a role in the stress response to heavy metals such as copper, probably in a fos-1/kgb-1-dependent manner.


ensembl_gene_id: F53A9.4.1
symbol: jbts-14
gene_biotype: protein_coding
description:
  Transmembrane protein 237 homolog; Component of the transition zone in primary cilia. Required for ciliogenesis; Belongs to the TMEM237 family.


ensembl_gene_id: F53B1.7.1
symbol: gpa-5
gene_biotype: protein_coding
description:
  Guanine nucleotide-binding protein alpha-5 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems; Belongs to the G-alpha family.


ensembl_gene_id: F53B2.3.1
symbol: eak-4
gene_biotype: protein_coding
description:
  Protein eak-4; Together with eak-6 and sdf-9, negatively regulates dauer larva formation downstream of insulin-like receptor daf-2 and in parallel with age-1, pdk-1 and akt-1.


ensembl_gene_id: F53B6.1.1
symbol: tsp-15
gene_biotype: protein_coding
description:
  Tetraspanin-15; Plays a role in cuticle biogenesis. In complex with doxa-1 and the dual oxidase bli-3, promotes the generation of reactive oxygen species (ROS) and tyrosine cross-linking of collagen, thus stabilizing cuticular extracellular matrix ; Belongs to the tetraspanin (TM4SF) family.


ensembl_gene_id: F53B6.2a.1
symbol: madd-4
gene_biotype: protein_coding
description:
  Protein madd-4; Component of an extracellular matrix cue that is involved in the guidance of dorsoventral midline migrations and in the specification of postsynaptic domains at neuromuscular junctions (NMJs). Acts as a ligand for the netrin receptor unc-40 and the neuroligin receptor nlg-1. Secreted by the dorsal and ventral nerve cords to attract sensory axons and muscle membrane extensions called muscle arms. In parallel with unc-6 and slt-1, involved in the netrin receptor unc-40 dependent guidance of the AVM and PVM mechanosensory axons along the dorsal-ventral axis. The unc-40 cor [...]


ensembl_gene_id: F53B7.3.2
symbol: isy-1
gene_biotype: protein_coding
description:
  Protein isy-1; Regulates the processing of the mir-60 microRNA (miRNA), which in turn negatively regulates the expression of the transcription factor zip-10. Does not affect the splicing of zip-10 ; Belongs to the ISY1 family.


ensembl_gene_id: F53C11.3.1
symbol: F53C11.3
gene_biotype: protein_coding
description:
  Uncharacterized oxidoreductase F53C11.3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily.


ensembl_gene_id: F53E2.2.2
symbol: unc-60-2
gene_biotype: protein_coding
description:
  Actin-depolymerizing factor 1, isoforms a/b; Depolymerizes growing actin filaments in muscle cells; required for the assembly of actin filaments into the functional contractile myofilament lattice of muscle. Competes with unc-87 for actin binding and inhibits the actin-bundling activity of unc-87.


ensembl_gene_id: F53F10.3.1
symbol: mpc-2
gene_biotype: protein_coding
description:
  Probable mitochondrial pyruvate carrier 2; May mediate the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.


ensembl_gene_id: F53F4.10.1
symbol: F53F4.10
gene_biotype: protein_coding
description:
  Probable NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).


ensembl_gene_id: F53F4.3.1
symbol: tbcb-1
gene_biotype: protein_coding
description:
  Tubulin-specific chaperone B; Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer.


ensembl_gene_id: F53G12.1.2
symbol: rab-11.1
gene_biotype: protein_coding
description:
  Ras-related protein rab-11.1; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Involved in regulating the meiotic maturation of oocytes. Plays a role in egg shell formation, regulating exocytosis of chondroitin proteoglycans following fertilization. Controls cor [...]


ensembl_gene_id: F53G12.10.3
symbol: rpl-7
gene_biotype: protein_coding
description:
  60S ribosomal protein L7; Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs (By similarity).


ensembl_gene_id: F53G12.6.1
symbol: spe-8
gene_biotype: protein_coding
description:
  Spermatocyte protein spe-8; Probable non-receptor tyrosine-protein kinase which plays a role in spermatid activation (spermiogenesis) in hermaphrodites.


ensembl_gene_id: F53G2.7.1
symbol: mnat-1
gene_biotype: protein_coding
description:
  CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex.


ensembl_gene_id: F53H10.2a.1
symbol: saeg-1
gene_biotype: protein_coding
description:
  Suppressor of activated egl-4 protein 1; As a likely component of a histone deacetylase complex, together with saeg-2 and hda-2, functions downstream of the cAMP- dependent kinase egl-4 to regulate the expression of genes required for egg-laying and foraging.


ensembl_gene_id: F53H8.2.1
symbol: arr-1
gene_biotype: protein_coding
description:
  Beta-arrestin arr-1; Adapter protein required for olfactory adaptation and recovery to volatile odorants, probably by desensitization of G-protein coupled receptors (GPCR). May play a role in clathrin-mediated GPCR endocytosis. Acts as positive regulator of insulin-like daf-2 signaling pathway probably by forming a complex with mpz-1 and phosphatase daf-18 likely resulting in daf-18 inhibition. Involved in egg-laying.


ensembl_gene_id: F53H8.4.1
symbol: sms-2
gene_biotype: protein_coding
description:
  Phosphatidylcholine:ceramide cholinephosphotransferase 2; Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide.


ensembl_gene_id: F54A3.3.1
symbol: cct-3
gene_biotype: protein_coding
description:
  T-complex protein 1 subunit gamma; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis (By similarity). Known to play a role, in vitro, in the folding of actin and tubulin (By similarity). Plays a role in microtubule polymerization.


ensembl_gene_id: F54A3.5.1
symbol: F54A3.5
gene_biotype: protein_coding
description:
  MICOS complex subunit Mic10; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.


ensembl_gene_id: F54A5.3a.1
symbol: shc-1
gene_biotype: protein_coding
description:
  SHC-transforming protein homolog 1; Scaffold protein which plays an important role in the activation of the JNK pathway composed of mlk-1, mek-1 and kgb-1; by bringing together mek-1 and mlk-1, promotes mlk-1-mediated phosphorylation and activation of mek-1 which in turn phosphorylates kgb-1. In addition, negatively modulates the activation of the insulin/IGF-1-like signaling (IIS) probably by inhibiting the insulin receptor daf-2. Positively regulates the activity of the transcription factor daf-16/FOXO by both inhibiting IIS and activating the JNK pathway. Involved in the response to [...]


ensembl_gene_id: F54B11.3a.1
symbol: unc-84
gene_biotype: protein_coding
description:
  Nuclear migration and anchoring protein unc-84; Involved in nuclear migration and anchoring in hypodermal precursor cells. Most likely recruits anc-1 to the nuclear envelope where anc-1 functions to tether the nucleus to the actin cytoskeleton. Component of the unc-83-unc-84 LINC (LInker of Nucleoskeleton and Cytoskeleton) complex where it recruits and interacts with unc-83 to form a bridge connecting the nuclear envelope to the cytoskeleton which allows for nuclear transport along microtubules. Its role in nuclear migration may be in association with lamin, lmn-1. Regulates nuclear mi [...]


ensembl_gene_id: F54B3.3.1
symbol: atad-3
gene_biotype: protein_coding
description:
  ATPase family AAA domain-containing protein 3; Essential for mitochondrial network organization, mitochondrial metabolism and cell growth at organism and cellular level. Important during development for the up-regulation of mitochondrial activity during the transition to higher larval stages. Regulates mitochondrial iron homeostasis. May play an important role in mitochondrial protein synthesis (By similarity). May also participate in mitochondrial DNA replication (By similarity). May bind to mitochondrial DNA D-loops and contribute to nucleoid stability (By similarity). Plays a role i [...]


ensembl_gene_id: F54C1.2.1
symbol: dom-3
gene_biotype: protein_coding
description:
  Decapping nuclease dom-3; Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping and pyrophosphohydrolase activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA. Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5' end triphosphate to release pyrophosphates (By similarity).


ensembl_gene_id: F54C1.3a.1
symbol: mes-3
gene_biotype: protein_coding
description:
  Polycomb protein mes-3; Component of a Polycomb group (PcG) complex. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. The mes-2/mes-3/mes- 6 complex may participate in the global inactivation of the X chromosomes in germline cells. The complex may act via methylation of histone H3 'Lys-27', rendering chromatin heritably changed in its expressibility. This complex is [...]


ensembl_gene_id: F54C1.5a.1
symbol: dyf-1
gene_biotype: protein_coding
description:
  Tetratricopeptide repeat protein 30 homolog; Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip. Specifically required for the kinesin osm-3 to dock onto and move the IFT particles which contain these precursors. Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. May be required for ciliary entrance and transport of specific ciliary cargo proteins such as che-3 which are related to motili [...]


ensembl_gene_id: F54C4.2.1
symbol: spt-4
gene_biotype: protein_coding
description:
  Transcription elongation factor SPT4; May function as a component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II. DSIF may enhance transcriptional pausing at sites proximal to the promoter, which may in turn facilitate the assembly of an elongation competent RNA polymerase II complex.


ensembl_gene_id: F54C8.1.1
symbol: F54C8.1
gene_biotype: protein_coding
description:
  Probable 3-hydroxyacyl-CoA dehydrogenase F54C8.1; Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.


ensembl_gene_id: F54C8.2.1
symbol: cpar-1
gene_biotype: protein_coding
description:
  Histone H3-like centromeric protein cpar-1; Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. Not required for chromosome segregation during meiosis.


ensembl_gene_id: F54C8.3.2
symbol: emb-30
gene_biotype: protein_coding
description:
  Abnormal embryogenesis protein 30; Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (By similarity). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins (By similarity). Developmental role in early embryogenesis and the metaphase to anaphase transition in oocyte and spermatocyte meiosis and mitosis in somatic and germ cells. Required for embryonic anterior- posterior axis formation. Negatively regulat [...]


ensembl_gene_id: F54C9.1.2
symbol: iff-2
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 5A-2; mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis (By similarity). Acts in somatic tissues and its function in the soma is essential for normal growth and reproduction.


ensembl_gene_id: F54C9.10.2
symbol: arl-1
gene_biotype: protein_coding
description:
  ADP-ribosylation factor-like protein 1; GTP-binding protein that may be involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. Plays a role in male tail tip morphogenesis.


ensembl_gene_id: F54C9.5.1
symbol: rpl-5
gene_biotype: protein_coding
description:
  60S ribosomal protein L5; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through  [...]


ensembl_gene_id: F54C9.8.1
symbol: puf-5
gene_biotype: protein_coding
description:
  Pumilio domain-containing protein 5; RNA-binding protein that binds to the consensus sequence 5'- CUCUGUAUCUUGU-3' in mRNA 3'-UTRs and modulates mRNA expression and stability. Functions redundantly with puf-6 and puf-7 in oocyte formation and organization, early embryonic cell divisions, and repression of expression of glp-1 and other maternal mRNAs in late oogenesis.


ensembl_gene_id: F54D1.4a.1
symbol: nhr-7
gene_biotype: protein_coding
description:
  Nuclear hormone receptor family member nhr-7; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family.


ensembl_gene_id: F54D5.11.1
symbol: gtf-2E2
gene_biotype: protein_coding
description:
  Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.


ensembl_gene_id: F54D5.14.1
symbol: smc-6
gene_biotype: protein_coding
description:
  Structural maintenance of chromosomes protein 6 homolog smc-6; Core component of the smc-5/smc-6 complex. Involved in DNA double-strand break repair by promoting sister- chromatid homologous recombination during meiosis. Also plays a role in the DNA damage repair of ultraviolet (UV) radiation-induced DNA lesions. Promotes efficient DNA replication.


ensembl_gene_id: F54D7.4.1
symbol: zig-7
gene_biotype: protein_coding
description:
  Zwei Ig domain protein zig-7; Probably not involved in maintaining the position of ASI and ASH head neuron cell bodies and ventral nerve cord axons of PVQ, PVP, RMEV, AVK and HSN neurons.


ensembl_gene_id: F54D8.2.1
symbol: cox-6A
gene_biotype: protein_coding
description:
  Cytochrome c oxidase subunit 6A, mitochondrial; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane [...]


ensembl_gene_id: F54E7.1a.1
symbol: pst-2
gene_biotype: protein_coding
description:
  Adenosine 3'-phospho 5'-phosphosulfate transporter 2; Mediates the transport of adenosine 3'-phospho 5'- phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi (By similarity).


ensembl_gene_id: F54E7.3i.1
symbol: par-3
gene_biotype: protein_coding
description:
  Partitioning defective protein 3; In cooperation with pkc-3, required for establishing cell polarity and regulating spindle orientation in the early embryo. Localization is crucial for recruiting par-6 and pkc-3 to the peripheral apical cortex and restricting par-2 to basolateral surfaces. Necessary for apicobasal and anterior-posterior asymmetries associated with cell adhesion and gastrulation during the first few cycles of embryogenesis, and also for epithelial cell polarity in the distal spermatheca. Regulates the asymmetric localization of csnk-1, ppk-1 and gpr-1/2 during the first [...]


ensembl_gene_id: F54E7.7.1
symbol: rcan-1
gene_biotype: protein_coding
description:
  Calcipressin-like protein; Inhibits tax-6/calcineurin A phosphatase activity and thereby negatively regulates calcineurin-mediated functions. Plays a role in modulating temperature-dependent calcium responses in AFD neurons and in addition, also negatively regulates thermotaxis in a tax-6-dependent manner in AFD neurons. In response to changes in intracellular calcium levels may also regulate nuclear translocation of transcriptional regulators such as crtc-1. May play a role in regulating body size. Plays a role in male tail tip morphogenesis. Belongs to the RCAN family.


ensembl_gene_id: F54F2.1.1
symbol: pat-2
gene_biotype: protein_coding
description:
  Integrin alpha pat-2; Required for muscle development probably through the regulation of the actin-myosin cytoskeleton. Component of an integrin containing attachment complex, which is required for muscle maintenance. During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles, probably through lamins such as epi-1, lam-2 and unc-52. Required for distal tip cell migration and dorsal pathfinding. Required for egg-laying. May play a role in cell motility and cell-cell interactions (By similarity). Plays a role in vu [...]


ensembl_gene_id: F54F2.2a.2
symbol: zfp-1
gene_biotype: protein_coding
description:
  Zinc finger protein zfp-1; Recruits the histone methyltransferase dot-1.1 to chromatin to methylate 'Lys-79' of histone H3 and activate transcription. Recognizes and binds histone H3 methylated at 'Lys- 4' (H3K4me) at the promoters of target genes. During stress, the zfp-1-dot-1.1 complex also plays a role in the deubiquitination of histone H2B sites, which negatively modulates the RNA polymerase II-induced transcription of highly expressed genes. In response to stress, binds to the pdk-1 promoter to negatively regulate pdk-1 expression, which negatively modulates daf-16/FOXO-mediated  [...]


ensembl_gene_id: F54F3.4.1
symbol: dhrs-4
gene_biotype: protein_coding
description:
  Dehydrogenase/reductase SDR family member 4; Catalyzes the reduction of isatin, 4-oxonon-2-enal, 9,10- phenanthrenequinone, menadione, 2,3-hexaenadione, 3,4-hexanedione and 2,3-heptanedione.


ensembl_gene_id: F54F7.5.1
symbol: mes-1
gene_biotype: protein_coding
description:
  Protein mes-1; During early embryogenesis, controls asymmetric cell division and the asymmetric localization of P granules of germline precursor P2 and its descendant P3. Probably upstream of tyrosine kinase src-1, plays a role in endoderm development by controlling spindle orientation during EMS blastomere cell division. Controls EMS spindle orientation probably by promoting lin-5 and gpr-1/2 enrichment at, and let-99 exclusion from the junction between P2 and EMS cells.


ensembl_gene_id: F54G8.2.1
symbol: dgk-3
gene_biotype: protein_coding
description:
  Probable diacylglycerol kinase 3; Involved in AFD-neuron mediated thermotaxis. Regulates behavior to environmental temperature. Thought to have a role in olfactory adaptation by affecting diacylglycerol levels. Belongs to the eukaryotic diacylglycerol kinase family.


ensembl_gene_id: F54G8.3.1
symbol: ina-1
gene_biotype: protein_coding
description:
  Integrin alpha ina-1; Plays a role in cell migration, axon fasciculation, and morphogenesis. During gonad morphogenesis, involved in distal tip cells (DTC)-mediated guidance of gonad elongation, in maintaining their sharp tapering morphology and in their migration. Involved in the anterior-posterior positioning of QR neuroblast descendants by regulating the migratory speed of QR.p. Probably by acting as a receptor for apoptotic cells, plays a role in the clearance of apoptotic cells during mid-embryogenesis. Belongs to the integrin alpha chain family.


ensembl_gene_id: F54H12.1a.1
symbol: aco-2
gene_biotype: protein_coding
description:
  Probable aconitate hydratase, mitochondrial; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.


ensembl_gene_id: F54H12.6.1
symbol: eef-1B.1
gene_biotype: protein_coding
description:
  Probable elongation factor 1-beta/1-delta 1; EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP; Belongs to the EF-1-beta/EF-1-delta family.


ensembl_gene_id: F55A11.2.1
symbol: syx-5
gene_biotype: protein_coding
description:
  Putative syntaxin-5; Potentially involved in docking of synaptic vesicles at presynaptic active zones; Belongs to the syntaxin family.


ensembl_gene_id: F55A11.3.1
symbol: sel-11
gene_biotype: protein_coding
description:
  E3 ubiquitin-protein ligase hrd-1; Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated ubc-7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system, which is also called the ER-associated degradation (ERAD) system, involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins. Protects cells from ER stress-induced apoptosis. Thought to play  [...]


ensembl_gene_id: F55A11.4a.1
symbol: F55A11.4
gene_biotype: protein_coding
description:
  Putative calcium-binding mitochondrial carrier F55A11.4; Mitochondrial and calcium-binding carrier that catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane.


ensembl_gene_id: F55A12.8.1
symbol: nath-10
gene_biotype: protein_coding
description:
  RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires a tRNA-binding adapter protein for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.


ensembl_gene_id: F55A3.3.1
symbol: spt-16
gene_biotype: protein_coding
description:
  FACT complex subunit spt-16; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment  [...]


ensembl_gene_id: F55A8.2h.1
symbol: egl-4
gene_biotype: protein_coding
description:
  cGMP-dependent protein kinase egl-4; Promotes chemoreceptor gene expression in response to increased cGMP levels by antagonizing the gene repression functions of the class II HDAC hda-4 and the mef-2 transcription factor. Regulates gene expression via recruitment of a histone deacetylase complex containing hda-2, saeg-1 and saeg-2. Represses body size and lifespan through the dbl-1 and insulin pathways, respectively. May also signal through daf-3 and/or daf-5. Role in egg-laying, dauer formation and motility. Regulates behavioral responses to various chemosensory stimuli in sensory neu [...]


ensembl_gene_id: F55B12.1.1
symbol: ceh-24
gene_biotype: protein_coding
description:
  Homeobox protein ceh-24; Probable transcriptional regulator that is required in neural development for the normal formation of sublateral cholinergic motor neuron processes. Plays a role in regulating the expression of acetylcholine transporter protein unc-17 in the sublateral processes. In particular, it is required in sublateral motor neurons for a left- right turning behavior that occurs during the lethargus phase of the normal sleep process called 'flipping'. During 'flipping' animals rotate 180 degrees about their longitudinal axis.


ensembl_gene_id: F55B12.3a.1
symbol: sel-10
gene_biotype: protein_coding
description:
  F-box/WD repeat-containing protein sel-10; Probable substrate recognition component of SCF (SKP1-CUL-F- box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates synapse elimination in early development in the motor neuron HSNL. Cell autonomous negative regulator of lin-12/Notch-mediated signaling, with respect to lin-12 activity in cell fate decisions and tumorigenesis. May target the intracellular domains of lin-12/Notch proteins for ubiquitin-dependent degradation. Involved in sex determin [...]


ensembl_gene_id: F55B12.5.2
symbol: nrf-5
gene_biotype: protein_coding
description:
  Nose resistant to fluoxetine protein 5; Plays a role in the uptake of a range of molecules including phosphatidylserine, lipids and xenobiotic compounds from the intestine to surrounding tissues. Possesses lipid transfer activity. Mediates transport of lipids from intestine to reproductive tract. Binds phosphatidylserine. Plays a role in efficient clearance of cell corpses by mediating phosphatidylserine appearance on phagocytic cells, thus promoting phagocytic engulfment of apoptotic cells. Vital for embryonic development.


ensembl_gene_id: F55C10.1a.1
symbol: cnb-1
gene_biotype: protein_coding
description:
  Protein phosphatase 2B regulatory subunit cnb-1; Regulatory subunit of tax-6/calcineurin A, a calcium- dependent, calmodulin-stimulated protein phosphatase. Confers calcium sensitivity. Plays a role in egg- laying, fertility, growth, movement and cuticle development. Plays a role in sensitivity to CO2 levels. Regulates expression of tax-6 inhibitor rcn-1. Negatively regulates nicotinic acetylcholine receptor (nAChR) sensitivity to nicotine. Negatively regulates lifespan. Involved in endocytic processes including coelomocyte endocytosis, intestine apical endocytosis and synaptic vesicle [...]


ensembl_gene_id: F55C10.3.1
symbol: col-155
gene_biotype: protein_coding
description:
  Putative cuticle collagen 155; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment (By similarity).


ensembl_gene_id: F55C5.5.1
symbol: tsfm-1
gene_biotype: protein_coding
description:
  Elongation factor Ts, mitochondrial; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family.


ensembl_gene_id: F55C5.8.1
symbol: srpa-68
gene_biotype: protein_coding
description:
  Probable signal recognition particle subunit SRP68; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP68 binds the 7S RNA, SRP72 binds to this complex subsequently. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function (By similarity).


ensembl_gene_id: F55D10.3.1
symbol: glit-1
gene_biotype: protein_coding
description:
  Neuroligin-like protein glit-1; Probable neuronal cell surface protein thought to be involved in cell-cell-interactions (Probable). Confers protection against oxidative stress. Plays a role in protecting dopaminergic neurons against oxidative stress-induced neurodegeneration ; Belongs to the type-B carboxylesterase/lipase family.


ensembl_gene_id: F55D10.5.1
symbol: acc-3
gene_biotype: protein_coding
description:
  Acetylcholine-gated chloride channel subunit acc-3; Probable acetylcholine-gated chloride channel regulatory subunit. Does not have ion channel activity alone as a homopentamer, but forms a functional heteropentameric ion channel with acc-1. Belongs to the ligand-gated ion channel (TC 1.A.9) family.


ensembl_gene_id: F55D12.4a.1
symbol: unc-55
gene_biotype: protein_coding
description:
  Nuclear hormone receptor unc-55; Acts as a transcriptional regulator. Required for ventral D (VD) motor neurons to adopt their normal synaptic pattern. Suppresses expression of flp-13 in VD motor neurons to ensure formation of the correct synaptic pattern. Maintains low cAMP levels in VD motor neurons by enhancing expression of pde-4 which hydrolyzes cAMP and repressing expression of acy-1 which catalyzes cAMP formation. This prevents respecification of synapses by VD neurons. During copulation, required in males for correct movement of the spicules, a pair of prong-like structures whi [...]


ensembl_gene_id: F55F3.3a.1
symbol: nkb-3
gene_biotype: protein_coding
description:
  Probable sodium/potassium-transporting ATPase subunit beta-3; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane (By similarity). Implicated in genomic response to various soil bacteria that affects fitness, lifespan and brood size.


ensembl_gene_id: F55F8.5.2
symbol: wdr-12
gene_biotype: protein_coding
description:
  Ribosome biogenesis protein WDR12 homolog; Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit; Belongs to the WD repeat WDR12/YTM1 family.


ensembl_gene_id: F55G1.13.1
symbol: egas-4
gene_biotype: protein_coding
description:
  EGF plus ASC domain ion channel; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.


ensembl_gene_id: F55G1.4.2
symbol: rod-1
gene_biotype: protein_coding
description:
  Kinetochore-associated protein rod-1; Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for chromosome segregation, the assembly of the dynein-dynactin and mdf-1-mdf-2 complexes onto kinetochores and spindle pole separation. Plays a role in nuclear envelope breakdown. Its function related to the spindle assembly machinery and kinetochore-microtubule attachments likely depends on its association in the mitotic RZZ complex. The RZZ complex recruits the spindly-like protein spdl-1 to kinetochores. To prevent irregular chromosome [...]


ensembl_gene_id: F55G1.8.2
symbol: plk-3
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase plk-3; May be required for cell division and may have a role during G1 or S phase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.


ensembl_gene_id: F55H2.1b.1
symbol: sod-4
gene_biotype: protein_coding
description:
  Extracellular superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family.


ensembl_gene_id: F55H2.2.3
symbol: vha-14
gene_biotype: protein_coding
description:
  V-type proton ATPase subunit D; Subunit of the peripheral V1 complex of vacuolar ATPase. V- ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system; Belongs to the V-ATPase D subunit family.


ensembl_gene_id: F55H2.6.1
symbol: clu-1
gene_biotype: protein_coding
description:
  Clustered mitochondria protein homolog; mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria; Belongs to the CLU family.


ensembl_gene_id: F56A11.1.2
symbol: gex-2
gene_biotype: protein_coding
description:
  Cytoplasmic FMR1-interacting protein homolog; Required for initial steps of body morphogenesis. May play a role in egg laying and yolk protein clatherin-mediated endocytosis by oocytes during oogenesis. Plays a role in the formation of muscle connections, also called muscle arm extensions, between the body wall and the motor axons in the dorsal and ventral cord.


ensembl_gene_id: F56A11.3.1
symbol: efn-4
gene_biotype: protein_coding
description:
  Ephrin-4; Regulates the formation or stabilization of cell-cell contacts at several stages of epithelial morphogenesis. In early embryonic development, involved in ventral closure of the epidermis. During male tail morphogenesis, regulates precursor cell sorting together with mab-20 and allows the formation of distinct sensory rays. Probably acts as a ligand for lad-2 to regulate axon guidance of several neurons including SDQL, SDQR, SMD and PLN neurons during neurogenesis.


ensembl_gene_id: F56A12.1.1
symbol: unc-39
gene_biotype: protein_coding
description:
  Homeobox protein unc-39; Probable transcription factor required for differentiation and migration of neuronal cells, such as RID and CAN neurons. Specifically, plays a role in the terminal differentiation of RID peptidergic neurons. Also required for CAN neuron axon guidance.


ensembl_gene_id: F56A3.2.1
symbol: slx-1
gene_biotype: protein_coding
description:
  Structure-specific endonuclease subunit SLX1 homolog; Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA (Potential). Has a preference for replication forks over 5' flap structures or Holliday junctions and shows much lower activity toward 3' flap structures. Required for proper crossover distribution through inhibition of crossover formation at the c [...]


ensembl_gene_id: F56A3.4.1
symbol: spd-5
gene_biotype: protein_coding
description:
  Spindle-defective protein 5; Plays a central role in centrosome maturation and mitotic spindle assembly during the first division of the zygote. Required for the centrosomal localization of air-1 and zyg-9. Probably not required in late embryogenesis and during larval development.


ensembl_gene_id: F56A8.7a.2
symbol: unc-64
gene_biotype: protein_coding
description:
  Syntaxin-1A homolog; Plays a critical role in several secretory processes, including cuticle secretion and neurotransmitter release, and probably assists in neuronal membrane maturation or the final stages of neuronal differentiation. Essential for embryonic viability and development. Has a role in dauer formation and adult life span. Required for locomotion. Probably by regulating neuronal transmission downstream of lin-3 and receptor lin-23 and phospholipase plc-3 and upstream of innexin unc-7 and egl-4/PKG in ALA neurons, involved in the decrease in pharyngeal pumping during the qui [...]


ensembl_gene_id: F56B6.2a.1
symbol: rgs-7
gene_biotype: protein_coding
description:
  Regulator of G-protein signaling rgs-7; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunit egl-30 (G-alpha(q)), thereby driving it into its inactive GDP-bound form. May organize egl-30 into a stable multiprotein signaling complex, and thereby persistently inhibit egl-30 when triggered by calcium or phospholipids.


ensembl_gene_id: F56B6.4a.1
symbol: gyg-1
gene_biotype: protein_coding
description:
  Glycogenin-1; Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for gsy-1.


ensembl_gene_id: F56C11.1.1
symbol: bli-3
gene_biotype: protein_coding
description:
  Dual oxidase 1; Plays a role in cuticle biogenesis. In complex with doxa-1 and tsp-15, produces reactive oxygen species (ROS), which are probably used by mlt-7 for tyrosine cross-linking, thus stabilizing cuticular extracellular matrix. May regulate the production of ROS by playing a role in modulating proline catabolism. Required in combination with mlt-7 for correct formation of cross-links in cuticle collagens. Association with the GTPase rho-1 promotes ROS production and this interaction may be modulated by memo-1, in order to control the oxidative stress response and longevity. In [...]


ensembl_gene_id: F56C9.1.1
symbol: gsp-2
gene_biotype: protein_coding
description:
  Serine/threonine-protein phosphatase PP1-beta; Serine/threonine-protein phosphatase essential for chromosomal dynamics during meiosis and mitosis. During meiosis, promotes chromosomal cohesion and germline immortality via a small RNA- mediated genome silencing pathway. Antagonizes the function of air-2 kinase during meiosis I and mitosis to promote chromatid cohesion and spindle attachment. Dephosphorylates histone H3 at 'Ser-10' (Probable). Dephosphorylates histone H3 at 'Thr-3' (Probable). Also involved in the activation of chloride channel clh-3 during cell swelling and meiotic matu [...]


ensembl_gene_id: F56D1.2.1
symbol: ilcr-2
gene_biotype: protein_coding
description:
  Interleukin cytokine receptor-related protein 2; Forms a receptor complex together with receptor ilcr-1, which upon activation acts as a modulator of neuronal activity. Binding of the ligand ilc-17.1 to the ilcr-1/2 receptor complex triggers a signaling cascade that activates the downsteam signaling components actl-1, pik-1 and nfki-1, and results in increased neuronal activity in RMG interneurons in response to input from oxygen-sensing neurons. This leads to increased animal movement and promotes aggregation behavior.


ensembl_gene_id: F56D1.3.1
symbol: mrps-16
gene_biotype: protein_coding
description:
  Probable 28S ribosomal protein S16, mitochondrial; Belongs to the bacterial ribosomal protein bS16 family.


ensembl_gene_id: F56D1.4b.1
symbol: clr-1
gene_biotype: protein_coding
description:
  Receptor-type tyrosine-protein phosphatase; Possesses an intrinsic protein tyrosine phosphatase (PTPase) activity. Regulates egl-15 activity which is required for hypodermis-mediated fluid homeostasis and protein degradation in muscle. During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles. Plays a role in nicotinic acetylcholine receptor (nAChR)-mediated sensitivity to nicotine. Regulates synaptic levels of nAchR subunit lev-1 in the nerve cord. Promotes the outgrowth of the quaternary dendritic branches of  [...]


ensembl_gene_id: F56D1.7.1
symbol: daz-1
gene_biotype: protein_coding
description:
  DAZ protein 1; RNA-binding protein that plays a central role in oogenesis, but not for spermatogenesis. Required for meiotic entry and germline differentiation, at the pachytene stage of meiosis I of female germline regardless of the sex of the soma. May act by regulating translation of specific mRNAs, possibly by binding to their 3'-UTR.


ensembl_gene_id: F56D2.6a.1
symbol: ddx-15
gene_biotype: protein_coding
description:
  Pre-mRNA-splicing factor ATP-dependent RNA helicase ddx-15; Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA.


ensembl_gene_id: F56D2.7.1
symbol: ced-6
gene_biotype: protein_coding
description:
  Cell death protein 6; May function as an adapter protein in a pathway that mediates recognition and phagocytosis of apoptotic cells during normal development. Promotes engulfment of cells at both early and late stages of apoptosis. Required for actin reorganization around apoptotic cells. Belongs to the ced-6 family.


ensembl_gene_id: F56F3.1.1
symbol: ifet-1
gene_biotype: protein_coding
description:
  Translational repressor ifet-1; Involved in translational repression of multiple mRNAs in the distal gonad. Recruited to the 3' untranslated region (UTR) of zif-1 by oma-1 and is required for translational repression of zif-1. May also be involved in translational repression of mei-1 through recruitment to the mei-1 3' UTR by oma-1. Required for oogenesis but not spermatogenesis, for P granule formation and for the localization of car-1 and cgh-1 to P granules. Required for normal spindle orientation in early embryos.


ensembl_gene_id: F56F4.5.1
symbol: pept-3
gene_biotype: protein_coding
description:
  Peptide transporter 3; Neuron-specific, H(+)-coupled oligopeptide transporter with broad specificity towards di- and tripeptides in a Na(+) and Cl(-)- independent manner. Shows H(+) channel activity in the absence of peptide substrates; Belongs to the PTR2/POT transporter (TC 2.A.17) family.


ensembl_gene_id: F56G4.5.1
symbol: png-1
gene_biotype: protein_coding
description:
  Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase; Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta- aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native protein [...]


ensembl_gene_id: F56H1.4.1
symbol: rpt-5
gene_biotype: protein_coding
description:
  26S protease regulatory subunit 6A; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required (By similarity). Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair (By similarity). Belongs to the heterohexameric ring of AAA [...]


ensembl_gene_id: F56H1.5.1
symbol: ccpp-1
gene_biotype: protein_coding
description:
  Cytosolic carboxypeptidase 1; Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation of proteins such as tubulins (Probable). Via the deglutamylation of tubulin, regulates the localization and velocity of kinesin motors and the structural integrity of microtubules in sensory cilia. In male CEM sensory neurons, regulates the cilia release of bioactive extracellular vesicles. Also regulates microtubule dynamics in uterine muscle cells.


ensembl_gene_id: F56H1.6.1
symbol: rad-8
gene_biotype: protein_coding
description:
  Reticulon-4-interacting protein 1, mitochondrial; Plays a role in oxygen metabolism in the mitochondria by regulating the levels of reactive oxygen species (ROS) thereby conferring resistance to oxidative stress. Involved in resistance to P.aeruginosa PA14 infection. Regulates lifespan. Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.


ensembl_gene_id: F56H11.1g.1
symbol: fbl-1
gene_biotype: protein_coding
description:
  Fibulin-1; Incorporated into fibronectin-containing matrix fibers. Plays a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Important for certain developmental processes and contributes to the supramolecular organization of ECM architecture, in particular to those of basement membranes.  [Isoform c]: Involved in the assembly of the flexible hemicentin-containing tracks found joining the pharynx and body-wall- muscle basement membranes; Belongs to the fibulin family.


ensembl_gene_id: F56H6.5.1
symbol: gmd-2
gene_biotype: protein_coding
description:
  GDP-mannose 4,6 dehydratase 2; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.


ensembl_gene_id: F56H9.3.1
symbol: gpa-8
gene_biotype: protein_coding
description:
  Guanine nucleotide-binding protein alpha-8 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems; Belongs to the G-alpha family.


ensembl_gene_id: F56H9.4b.1
symbol: gpa-9
gene_biotype: protein_coding
description:
  Guanine nucleotide-binding protein alpha-9 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.


ensembl_gene_id: F56H9.5.2
symbol: lin-25
gene_biotype: protein_coding
description:
  Protein lin-25; Participates in the inductive signaling pathway downstream of let-60 Ras and the RAF/MAP kinase cascade to regulate specification and differentiation of many cell types. Positively regulates the fate of vulval precursor cells. Required for induction of the P12 and excretory duct cell fates. In males, it is also required for proper formation of spicules. Does not function in the signaling pathway that promotes exit from pachytene. Plays a role in responses to M.nematophilum-mediated bacterial infection by promoting tail swelling and preventing constipation.


ensembl_gene_id: F57A10.5.1
symbol: nhr-60
gene_biotype: protein_coding
description:
  Nuclear hormone receptor family member nhr-60; Orphan nuclear receptor (Potential). Required for embryonic and larval morphogenesis and probably for seam cell positioning and migration; Belongs to the nuclear hormone receptor family.


ensembl_gene_id: F57B1.2.1
symbol: sun-1
gene_biotype: protein_coding
description:
  Sun domain-containing protein 1; Involved in centrosome attachment to the nucleus. Required for zyg-12 localization to the nuclear envelope. Together with pot-1, it is required to anchor telomeres to the nuclear envelope in embryos.


ensembl_gene_id: F57B10.10.1
symbol: dad-1
gene_biotype: protein_coding
description:
  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit dad-1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across th [...]


ensembl_gene_id: F57B10.11.1
symbol: bag-1
gene_biotype: protein_coding
description:
  BAG family molecular chaperone regulator 1; May inhibit the chaperone activity of HSP70/HSC70 by promoting substrate release in an ATP-dependent manner.


ensembl_gene_id: F57B10.12.1
symbol: mei-2
gene_biotype: protein_coding
description:
  Meiotic spindle formation protein 2; Forms a heterodimeric complex in conjunction with mei-1 which severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays. May act to target mei-1 within the cell. Required specifically for meiotic spindle formation in the female germline.


ensembl_gene_id: F57B10.3a.1
symbol: ipgm-1
gene_biotype: protein_coding
description:
  2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate.


ensembl_gene_id: F57B7.4.1
symbol: mig-17
gene_biotype: protein_coding
description:
  Metalloprotease mig-17; Metalloprotease. Acts in the basement membrane to control directional migration of distal tip cells (DTCs) along the body wall basement membranes, a key step that promotes gonad morphogenesis. Regulates DTC migration probably by recruiting fibulin fbl-1, type IV collagen let-2 and nidogen nid-1 to the gonad basement membrane thereby promoting the remodeling of the basement membrane. During larval development and probably upstream of basement membrane proteins fbl-1, let-2 and nid-1, regulates pharynx length, probably by regulating pharyngeal cell length. Does no [...]


ensembl_gene_id: F57B9.1.3
symbol: F57B9.1
gene_biotype: protein_coding
description:
  Putative pyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).


ensembl_gene_id: F57B9.10a.1
symbol: rpn-6.1
gene_biotype: protein_coding
description:
  Probable 26S proteasome regulatory subunit rpn-6.1; Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, rpn-6.1 is required for proteasome assembly. Plays a key role in increased proteasome activity in response to proteotoxic stress: induced by daf-16, promoting enhanced assembly of the 26S proteasome and higher proteasome activity, leading to extended lifespan.


ensembl_gene_id: F57B9.4a.1
symbol: coq-2
gene_biotype: protein_coding
description:
  4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate; Belongs to the UbiA prenyltransferase family.


ensembl_gene_id: F57B9.6a.2
symbol: inf-1
gene_biotype: protein_coding
description:
  Eukaryotic initiation factor 4A; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon; Belongs to the DEAD box helicase family. eIF4A subfamily.


ensembl_gene_id: F57C2.3.1
symbol: pot-2
gene_biotype: protein_coding
description:
  Protection of telomeres homolog 2; Telomeric DNA-binding protein, which binds to two or more single-stranded G-rich repeat sequences (G-strand), with high specificity to the 5'-TTAGGC-3' sequence. In addition, repeat sequence binding requires a 3' single-stranded telomeric overhang. Acts redundantly with pot-1 to negatively regulate telomerase-mediated telomere extension. Also regulates telomere length by the telomerase-independent telomere maintenance pathway called ALT (alternative lengthening of telomeres). Does not appear to have a role in anchoring telomeres to the nuclear envelop [...]


ensembl_gene_id: F57C7.3a.1
symbol: sdn-1
gene_biotype: protein_coding
description:
  Probable syndecan; Cell surface proteoglycan that bears heparan sulfate (By similarity). Required for correct mitotic spindle orientation of the ABar blastomere division plane and this may be through modulation of astral microtubule array, and in association with the wnt-signaling proteins mig-5 and dsh-2. Involved in the migration of AQR and PQR neurons, which descend from the Q neuroblasts. Promotes the axon guidance of D-type motor neurons.


ensembl_gene_id: F57C9.3a.1
symbol: glo-2
gene_biotype: protein_coding
description:
  Biogenesis of lysosome-related organelles complex 1 subunit 6; Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in gut granule biogenesis. Belongs to the BLOC1S6 family.


ensembl_gene_id: F57F5.2c.1
symbol: gcy-33
gene_biotype: protein_coding
description:
  Soluble guanylate cyclase gcy-33; Synthesizes cyclic GMP (cGMP) from GTP (By similarity). May be involved in sensitivity to quinine by regulating egl-4 activity through the production of cGMP. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.


ensembl_gene_id: F57F5.4a.2
symbol: add-2
gene_biotype: protein_coding
description:
  Adducin-related protein 2; Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network; Belongs to the aldolase class II family. Adducin subfamily.


ensembl_gene_id: F57F5.5c.1
symbol: pkc-1
gene_biotype: protein_coding
description:
  Protein kinase C-like 1B; PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. Involved in neuropeptide secretion in motor axons. Likely to act via the extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/MAPK) pathway in the signaling response to various sensory neurons; temperature, odor, taste, and osmolality. Its role in regulation differs depending on the neuron in which it is acting; thermosensation in AFD neurons, osmolality in ASH neuro [...]


ensembl_gene_id: F57H12.1.1
symbol: arf-3
gene_biotype: protein_coding
description:
  ADP-ribosylation factor related (20.5 kD) (Arf-3); Belongs to the small GTPase superfamily. Arf family.


ensembl_gene_id: F57H12.7a.1
symbol: mec-17
gene_biotype: protein_coding
description:
  Alpha-tubulin N-acetyltransferase 1; Specifically acetylates 'Lys-40' in alpha-tubulin/mec-12 on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act [...]


ensembl_gene_id: F58A3.2c.1
symbol: egl-15
gene_biotype: protein_coding
description:
  Myoblast growth factor receptor egl-15; Receptor tyrosine kinase required for larval development. May phosphorylate adapter protein soc-1 which in turn may result in the recruitment and/or activation of phosphatase ptp-2. May activate the Ras/MAPK kinase signaling pathway which includes sem-5, sos-1, let-60/Ras, lin-45/Raf, mek-2 and mpk-1. Acts in the hypodermis to regulate axon growth and fluid homeostasis. Activates protein degradation in muscles. Probably following interaction with ligand let-756, regulates negatively membrane protrusion from body wall muscles during larval develop [...]


ensembl_gene_id: F58A4.10.1
symbol: ubc-7
gene_biotype: protein_coding
description:
  Probable ubiquitin-conjugating enzyme E2 7; Catalyzes the covalent attachment of ubiquitin to other proteins.


ensembl_gene_id: F58A4.14a.1
symbol: bbs-4
gene_biotype: protein_coding
description:
  Bardet-Biedl syndrome 4 protein homolog; Component of the BBSome complex (By similarity). The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia (By similarity). The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function (By similarity). Required for proper BBSome complex assembly and its ciliary localization (By similarity). May be required for microtubule anchoring at the centrosome but not for microtubule nucleation (By similarity). May be required for the dynein- m [...]


ensembl_gene_id: F58A4.3.1
symbol: hcp-3
gene_biotype: protein_coding
description:
  Histone H3-like centromeric protein hcp-3; Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division (By similarity). Might promote cleavage furrow stability during cytokinesis. Not required for chromosome segregation during meiosis.


ensembl_gene_id: F58A4.4a.1
symbol: pri-1
gene_biotype: protein_coding
description:
  DNA primase small subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.


ensembl_gene_id: F58A4.8.1
symbol: tbg-1
gene_biotype: protein_coding
description:
  Tubulin gamma chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly.


ensembl_gene_id: F58A4.9.2
symbol: rpac-19
gene_biotype: protein_coding
description:
  Probable DNA-directed RNA polymerases I and III subunit RPAC2; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively (By similarity).


ensembl_gene_id: F58A6.10b.1
symbol: srb-12
gene_biotype: protein_coding
description:
  Serpentine receptor class beta-12; G-protein coupled receptor (Probable). Plays a role in the navigational capacity of sperm and promotes the targeting of sperm derived from males to the fertilization site in the uterus of hermaphrodites.


ensembl_gene_id: F58A6.11.1
symbol: srb-13
gene_biotype: protein_coding
description:
  Serpentine receptor class beta-13; G-protein coupled receptor that antagonizes the negative effects of the gcy-35 oxygen sensor on spermatogenesis. This leads to the maintenance of mitochondrial function in developing spermatocytes and/or spermatids prior to testis maturation during the early larval stages. Regulates the navigational capacity of sperm during hyperoxic conditions ensuring the proper targeting of sperm derived from males to the fertilization site in the uterus of hermaphrodites. May act in the same signaling pathway as the neuropeptide flp-21.


ensembl_gene_id: F58A6.6.1
symbol: srb-16
gene_biotype: protein_coding
description:
  Serpentine receptor class beta-16; G-protein coupled receptor (Probable). Plays a role in the navigational capacity of sperm and promotes the targeting of sperm derived from males to the fertilization site in the uterus of hermaphrodites ; Belongs to the nematode receptor-like protein srb family.


ensembl_gene_id: F58B3.2.1
symbol: lys-5
gene_biotype: protein_coding
description:
  Lysozyme-like protein 5; Plays a role in resistance to Gram-positive bacteria S.aureus or B.thuringiensis infection.


ensembl_gene_id: F58B6.2.1
symbol: exc-6
gene_biotype: protein_coding
description:
  Excretory canal abnormal protein 6; Constitutively active protein required for microtubule and F- actin growth, structural maintenance and organization during excretory cell tubulogenesis.


ensembl_gene_id: F58D5.4a.1
symbol: ksr-2
gene_biotype: protein_coding
description:
  Kinase suppressor of Ras B; Probable inactive protein kinase which positively regulates Ras-mediated signaling probably acting at the level of let-60/ras or/and lin-45/raf. In the germline, regulates meiotic progression during oogenesis and mpk-1 (isoform b) phosphorylation. Plays a role in meiotic recombination events. Functions redundantly with ksr-1 in the Ras-mediated regulation of larval survival, the development of excretory canal, in determining vulval precursor cell fate during vulval induction and in mpk-1 phosphorylation in somatic cells.


ensembl_gene_id: F58E6.1.1
symbol: sta-2
gene_biotype: protein_coding
description:
  Signal transducer and activator of transcription b; Carries out a dual function: signal transduction and activation of transcription (By similarity). By regulating the up- regulation in the epidermis of antimicrobial peptides nlp-29, plays a role in resistance to fungal infection and in the response to physical wounding and phorbol ester PMA treatment. Belongs to the transcription factor STAT family.


ensembl_gene_id: F58F12.1.1
symbol: F58F12.1
gene_biotype: protein_coding
description:
  ATP synthase subunit delta, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP turnover in the catalytic domain of F(1) is coupled via a rotary mechanism of the c [...]


ensembl_gene_id: F58G1.1.1
symbol: wago-4
gene_biotype: protein_coding
description:
  Argonaute protein wago-4; Argonaute protein which is involved in the endogenous small interfering RNA (endo-siRNA) pathway and is required for RNA-mediated gene silencing (RNAi) in the germline. Interacts with secondary 22G-RNAs, which are RNA-dependent RNA polymerase-derived endo-siRNAs, typically 22 nucleotides in length with a 5'guanosine residue. Also interacts with the mRNA targets of 22G-RNAs. Associates with znfx-1 to mediate small RNA-directed transgenerational epigenetic inheritance of both germline- and soma-expressed genes. Belongs to the argonaute family. WAGO subfamily.


ensembl_gene_id: F58G11.2a.1
symbol: rde-12
gene_biotype: protein_coding
description:
  DEAD-box ATP-dependent RNA helicase rde-12; Probable ATP-dependent RNA helicase involved in RNAi-mediated gene silencing. Specifically required in the endogenous siRNA pathway for biogenesis of secondary endogenous small interfering RNA (siRNA) intermediates called 22G-RNAs. May associate with and recruit rde- 10 to primary siRNA-targeted mRNA for secondary siRNA synthesis. May be recruited to target mRNAs by rde-1 and/or ergo-1.


ensembl_gene_id: F58G4.1.1
symbol: myo-5
gene_biotype: protein_coding
description:
  MYOsin heavy chain structural genes; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.


ensembl_gene_id: F58G6.4b.1
symbol: acc-1
gene_biotype: protein_coding
description:
  Acetylcholine-gated chloride channel subunit acc-1; Acetylcholine-gated chloride channel subunit. Forms functional homopentameric (in vitro) and functional heteropentameric ion channels with acc-3 and acc-4 ion channel subunits. Currents in channels are triggered in response to acetylcholine, but not in response to GABA, glutamate, glycine, histamine or dopamine.


ensembl_gene_id: F58H1.3a.2
symbol: F58H1.3
gene_biotype: protein_coding
description:
  Enolase-phosphatase E1; Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).


ensembl_gene_id: F58H12.1.1
symbol: kin-29
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase kin-29; Regulates chemoreceptor expression by phosphorylating the hda-4 class II histone deacetylase (HDAC) and inhibiting the gene repression functions of hda-4 and the mef-2 transcription factor, enabling the correct sensing and transduction of food signals. Role in determining body size, the dauer decision and serotonin-mediated egg laying. May modulate the Sma/Mab pathway and regulates development in the later larval stages.


ensembl_gene_id: F59A2.4a.1
symbol: clpf-1
gene_biotype: protein_coding
description:
  Protein clpf-1; Required for endonucleolytic cleavage during polyadenylation- dependent pre-mRNA 3'-end formation; Belongs to the Clp1 family. Clp1 subfamily.


ensembl_gene_id: F59A6.1a.1
symbol: nsy-1
gene_biotype: protein_coding
description:
  Mitogen-activated protein kinase kinase kinase nsy-1; Serine/threonine-protein kinase which, by phosphorylating and activating sek-1, plays an important role in the activation of the p38 pathway also composed of the downstream effectors sek-1 and pmk-1. Downstream of CaMKII unc-43 and adapter protein tir-1, plays a role in determining asymmetric cell fates in olfactory AWC neurons during neuronal development. Activation results in the repression of odorant receptor str-2 expression in one of the 2 AWC neurons. Involved in resistance to pathogenic Gram-positive and Gram-negative bacteri [...]


ensembl_gene_id: F59A7.4.1
symbol: hil-6
gene_biotype: protein_coding
description:
  Putative histone H1.6; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.


ensembl_gene_id: F59B1.9a.1
symbol: acr-23
gene_biotype: protein_coding
description:
  Betaine receptor acr-23; Betaine receptor that functions as a ligand-gated non- selective monovalent cation channel in mechanosensory neurons to maintain basal levels of locomotion. The channel is permeable to Na(+) and K(+) but not to Ba(2+) or Ca(2+) ions. Elicits current in response to betaine, very weak current in response to choline, virtually no current in response to acetylcholine and nicotine, and no current in response to glycine and GABA.


ensembl_gene_id: F59B10.1.1
symbol: myrf-1
gene_biotype: protein_coding
description:
  Myelin regulatory factor homolog 1, C-terminal; [Myelin regulatory factor homolog 1]: Constitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor homolog 1, N-terminal component that specifically activates transcription of genes involved in synaptic rewiring during nervous system maturation. [Myelin regulatory factor homolog 1, N-terminal]: Transcription factor that specifically activates expression of genes involved in synaptic rewiring during nervous system maturation. Specifically required for dorsal D (DD) GABA [...]


ensembl_gene_id: F59B2.2.1
symbol: skat-1
gene_biotype: protein_coding
description:
  Probable amino acid transporter skat-1; Plays a role in the accumulation of vital dyes and endogenous fluorescent compounds in lysosome related organelles. Has an effect on lysosome related organelle (LRO) function, in a pathway with serotonin.


ensembl_gene_id: F59B2.3.3
symbol: F59B2.3
gene_biotype: protein_coding
description:
  N-acetylglucosamine-6-phosphate deacetylase; Belongs to the metallo-dependent hydrolases superfamily. NagA family.


ensembl_gene_id: F59B2.5a.1
symbol: rpn-6.2
gene_biotype: protein_coding
description:
  Probable 26S proteasome regulatory subunit rpn-6.2; Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, rpn-6.2 is required for proteasome assembly (By similarity).


ensembl_gene_id: F59B2.6.1
symbol: zif-1
gene_biotype: protein_coding
description:
  Zinc finger-interacting factor 1; Probable substrate recognition component of a CBC (Cul2- ElonginB-ElonginC) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Ensures germline precursor cell asymmetry by targeting germline proteins for destruction if expressed in non-germline cells. This process also requires elc-1, cul-2, rbx-1 and ubc-2.


ensembl_gene_id: F59B2.7.1
symbol: rab-6.1
gene_biotype: protein_coding
description:
  Ras-related protein Rab-6.1; Protein transport. Probably involved in vesicular traffic (By similarity); Belongs to the small GTPase superfamily. Rab family.


ensembl_gene_id: F59C6.7a.1
symbol: che-13
gene_biotype: protein_coding
description:
  Intraflagellar transport protein che-13; Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. May be required for ciliary entrance and transport of specific ciliary cargo proteins such as che-3 which are related to motility. Required for the formation of chemosensory cilia that detect chemosensory cues ; Belongs to the IFT57 family.


ensembl_gene_id: F59D8.1.1
symbol: vit-3
gene_biotype: protein_coding
description:
  Vitellogenin-3; Precursor of the egg-yolk proteins that are sources of nutrients during embryonic development.


ensembl_gene_id: F59D8.2.1
symbol: vit-4
gene_biotype: protein_coding
description:
  Vitellogenin-4; Precursor of the egg-yolk proteins that are sources of nutrients during embryonic development.


ensembl_gene_id: F59E10.1.1
symbol: orc-2
gene_biotype: protein_coding
description:
  Origin recognition complex subunit 2; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (By similarity).


ensembl_gene_id: F59E10.2.1
symbol: cyn-4
gene_biotype: protein_coding
description:
  Peptidyl-prolyl cis-trans isomerase 4; May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins. May also function as a chaperone, playing a role in intracellular transport of proteins. May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on proteins. Influences the hermaphrodite switch from spermatogenesis to oogenesis. Required for body wall muscle cell development.


ensembl_gene_id: F59E10.3.1
symbol: copz-1
gene_biotype: protein_coding
description:
  Probable coatomer subunit zeta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity). The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its associatio [...]


ensembl_gene_id: F59E12.13.3
symbol: fut-3
gene_biotype: protein_coding
description:
  Alpha-(1,3)-fucosyltransferase fut-3; Catalyzes the addition of fucose in alpha 1-3 linkage. Unlike fut-1, does not add fucose to Man-alpha-1->3-(Man-alpha-1->6)-Man-beta- 1->4-GlcNAc-beta-1->4-GlcNAc-beta-1-Asn (M3), Man-alpha-1->3-(Man- alpha-1->6)-Man-beta-1->4-GlcNAc-beta-1->4-(Fuc-alpha-1->6)-GlcNAc- beta-1-Asn (M3F6) or GlcNAc-beta-1->2-Man-alpha-1->3-(GlcNAc-beta-1->2- Man-alpha-1->6)-Man-beta-1-4-GlcNAc-beta-1->4-(Fuc-alpha-1->6)-GlcNAc- beta-1-Asn (GnM3F6) acceptors; Belongs to the glycosyltransferase 10 family.


ensembl_gene_id: F59E12.2.2
symbol: zyg-1
gene_biotype: protein_coding
description:
  Probable serine/threonine-protein kinase zyg-1; Protein kinase that plays a central role in centrosome duplication, control of centrosome size, spindle formation and nuclear envelope breakdown during cell divisions. Paternal copy is required to regulate synthesis of daughter centrioles prior to fertilization. Maternal copy regulates centrosome duplication during later cell cycles. Functions upstream of sas-5 and sas-6, and is required for their localization to the centrosome. Its role in nuclear envelope breakdown is mediated by the spindly-like protein spdl-1 and the RZZ complex, whic [...]


ensembl_gene_id: F59E12.4b.1
symbol: npl-4.1
gene_biotype: protein_coding
description:
  Nuclear protein localization protein 4 homolog 1; In association with ufd-1 and ATPase cdc-48.1 and/or cdc- 48.2, involved in the cytoplasmic elimination of misfolded proteins exported from the ER. This pathway, known as ERAD, prevents the activation of the unfolded protein response (UPR) caused by the accumulation of misfolded proteins in the ER. During S phase and in association with ufd-1, cdc-48.1 and/or cdc-48.2 and ubxn-3, ensures the degradation of DNA licensing factor cdt-1 after the initiation of DNA replication and thus the disassembly of the DNA replication CGM helicase comp [...]


ensembl_gene_id: F59E12.5b.1
symbol: npl-4.2
gene_biotype: protein_coding
description:
  Nuclear protein localization protein 4 homolog 2; In association with ufd-1 and ATPase cdc-48.1 and/or cdc- 48.2, involved in the cytoplasmic elimination of misfolded proteins exported from the ER. This pathway, known as ERAD, prevents the activation of the unfolded protein response (UPR) caused by the accumulation of misfolded proteins in the ER. During S phase and in association with ufd-1, cdc-48.1 and/or cdc-48.2 and ubxn-3, ensures the degradation of DNA licensing factor cdt-1 after the initiation of DNA replication and thus the disassembly of the DNA replication CGM helicase comp [...]


ensembl_gene_id: F59F3.1.1
symbol: ver-3
gene_biotype: protein_coding
description:
  Tyrosine-protein kinase receptor ver-3; Receptor tyrosine kinase which may be involved, downstream of pvf-1, in the positioning of ray 1, the most anterior ray sensillum in the male tail.


ensembl_gene_id: F59F3.5.2
symbol: ver-4
gene_biotype: protein_coding
description:
  Tyrosine-protein kinase receptor ver-4; Receptor tyrosine kinase which may be involved, downstream of pvf-1, in the positioning of ray 1, the most anterior ray sensillum in the male tail.


ensembl_gene_id: F59F4.4.1
symbol: acl-1
gene_biotype: protein_coding
description:
  Putative 1-acyl-sn-glycerol-3-phosphate acyltransferase acl-1; Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.


ensembl_gene_id: F59F5.6.1
symbol: syd-2
gene_biotype: protein_coding
description:
  Liprin-alpha; May play a role in regulating the structure of the neuronal region, called the active zone, from which synaptic vesicles send neurotransmitter signals across the synapse. This may be in association with the liprin-beta protein hlb-1 ; Belongs to the liprin family. Liprin-alpha subfamily.


ensembl_gene_id: F59G1.1b.1
symbol: cgt-3
gene_biotype: protein_coding
description:
  Ceramide glucosyltransferase 3; Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide. Seems to be the major active form in the nematode.


ensembl_gene_id: F59G1.5.2
symbol: ptp-2
gene_biotype: protein_coding
description:
  Tyrosine-protein phosphatase non-receptor type ptp-2; Involved in embryonic and larval development. Plays a role in oogenesis by regulating mpk-1 phosphorylation and oocyte maturation in response to major sperm protein (MSP). During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles probably downstream of receptor egl-15. Plays a role in fluid homeostasis probably downstream of receptor egl-15 and adapter soc-1. Promotes vulva induction and negatively regulates fertility probably downstream of receptor let-23. N [...]


ensembl_gene_id: F59G1.7.1
symbol: frh-1
gene_biotype: protein_coding
description:
  Frataxin, mitochondrial; Promotes the biosynthesis of heme as well as the assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+). May be able to store large amounts of the metal in the form of a ferrihydrite mineral by oligomerization. Belongs to the frataxin family.


ensembl_gene_id: F59H5.1.1
symbol: gbas-1
gene_biotype: protein_coding
description:
  G-protein alpha subunit activating protein gbas-1; Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates G-protein alpha subunit goa-1.


ensembl_gene_id: H01A20.1.1
symbol: nhr-3
gene_biotype: protein_coding
description:
  Nuclear hormone receptor family member nhr-3; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family.


ensembl_gene_id: H02I12.1.1
symbol: cbd-1
gene_biotype: protein_coding
description:
  Chitin-binding domain protein cbd-1; In unfertilized oocytes, maintains egg-1 and egg-2 at the plasma membrane together with chitin synthase chs-1 and kinase mbk-2. Essential for the formation of a continuous and cohesive chitin layer following fertilization.


ensembl_gene_id: H03A11.1.1
symbol: famk-1
gene_biotype: protein_coding
description:
  Extracellular serine/threonine protein kinase CeFam20; Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs. Belongs to the FAM20 family.


ensembl_gene_id: H06H21.3.1
symbol: eif-1.A
gene_biotype: protein_coding
description:
  S1-like domain-containing protein; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.


ensembl_gene_id: H06H21.6.1
symbol: ubxn-6
gene_biotype: protein_coding
description:
  UBX domain-containing protein 6; Probably acts as an adapter for ATPase cdc-48.1 and/or cdc- 48.2, conferring substrate specificity. Involved in the lysosomal clearance of cellular material in diet restricted conditions.


ensembl_gene_id: H06I04.2a.1
symbol: sft-1
gene_biotype: protein_coding
description:
  SURF1-like protein; Probably involved in the biogenesis of the COX complex. Belongs to the SURF1 family.


ensembl_gene_id: H06I04.3a.1
symbol: H06I04.3
gene_biotype: protein_coding
description:
  Putative rRNA methyltransferase; Probable methyltransferase involved in the maturation of rRNA and in the biogenesis of ribosomal subunits.


ensembl_gene_id: H06I04.4a.3
symbol: ubl-1
gene_biotype: protein_coding
description:
  Ubiquitin-like protein 1-40S ribosomal protein S27a; In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.


ensembl_gene_id: H06O01.3a.1
symbol: ctg-1
gene_biotype: protein_coding
description:
  Protein ctg-1; Vesicle trafficking protein (Probable). Functions in uterine cells to promote basement membrane (BM) mobility and BM gap formation during tissue remodeling.


ensembl_gene_id: H12I13.4.1
symbol: fbf-1
gene_biotype: protein_coding
description:
  Fem-3 mRNA-binding factor 1; Involved in the control of stem cells and sex determination in the C.elegans hermaphrodite germline. May also play a role in the hermaphrodite germline proliferation and oogenesis. Binds specifically to the regulatory region of fem-3 3'-UTR and mediates the sperm/oocyte switch. Negatively regulates gld-3 expression, possibly by directly binding to two sites within the 3'-UTR of gld-3 isoform b. In association with the cye-1/cdk-2 complex, negatively regulates gld-1 expression in the distal germline cells of the mitotic zone. By binding to the 3'-UTR, repres [...]


ensembl_gene_id: H13N06.3a.1
symbol: gob-1
gene_biotype: protein_coding
description:
  Trehalose-phosphatase; Catalyzes the hydrolysis of trehalose 6-phosphate to trehalose and phosphate; prevents the accumulation of toxic levels of trehalose 6-phosphate.


ensembl_gene_id: H13N06.6b.1
symbol: tbh-1
gene_biotype: protein_coding
description:
  Tyramine beta-hydroxylase; Required for the conversion of tyramine to octopamine, a precursor of octapamine but probably itself a neurotransmitter. Involved in the regulation of egg laying, which is inhibited by tyramine. Due to its involvement in octopamine biosynthesis, also required for crtc-1-dependent regulation of AMPK-mediated longevity. Belongs to the copper type II ascorbate-dependent monooxygenase family.


ensembl_gene_id: H14A12.2a.1
symbol: fum-1
gene_biotype: protein_coding
description:
  Probable fumarate hydratase, mitochondrial; Catalyzes the reversible stereospecific interconversion of fumarate to L-malate. In mitochondrion, catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.


ensembl_gene_id: H14A12.4.1
symbol: mls-1
gene_biotype: protein_coding
description:
  T-box transcription factor mls-1; Probable transcription factor required for the cell fate specification of non-striated uterine muscle precursor cells. Furthermore, may function with the transcriptional corepressor unc-37.


ensembl_gene_id: H14E04.1.1
symbol: strm-1
gene_biotype: protein_coding
description:
  Sterol 4-C-methyltransferase strm-1; Catalyzes the methyl transfer from S-adenosyl-methionine to the C-4 of cholesterol and other sterols. May irreversibly shunt sterols away from dafachronic acid production. Dafachronic acids bind directly to the nuclear hormone receptor (NHR) daf-12, suppressing dauer formation and inducing reproductive growth.


ensembl_gene_id: H14E04.5.1
symbol: cic-1
gene_biotype: protein_coding
description:
  Cyclin-C; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin- dependent kinase cdk-8 that phosphoryl [...]


ensembl_gene_id: H15N14.1c.1
symbol: adr-1
gene_biotype: protein_coding
description:
  A-to-I RNA editing regulator adr-1; Required for the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. Does not have deaminase activity but binds to dsRNA and regulates A-to-I RNA editing, possibly by modulating the accessibility of the double-stranded RNA-specific adenosine deaminase adr-2 for target adenosines. Regulates editing efficiency of specific adenosines in 3' untranslated regions of target mRNAs. Represses editing efficiency of the Y75B8A.8 3' UTR in neurons. Required for correct expression and A-to-I editing of  [...]


ensembl_gene_id: H15N14.2a.1
symbol: nsf-1
gene_biotype: protein_coding
description:
  Vesicle-fusing ATPase; Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin (By similarity); Belongs to the AAA ATPase family.


ensembl_gene_id: H17B01.1b.1
symbol: fgt-1
gene_biotype: protein_coding
description:
  Facilitated glucose transporter protein 1; Facilitative glucose transporter that plays a role in glucose metabolism and regulation of longevity. May also play a role in lipid metabolism. Glucose transport activity of isoform a is competitively inhibited by mannose, galactose and fructose, suggesting ability to transport also other hexose sugars.


ensembl_gene_id: H19M22.3a.1
symbol: zmp-2
gene_biotype: protein_coding
description:
  Matrix metalloproteinase-B; Metalloprotease involved in molting, a process during larval stages in which a new cuticle is formed and the old cuticle is shed. Plays a role in thermotolerance probably by preventing the accumulation of oxidized lipoproteins and cholesterol.


ensembl_gene_id: H20J04.5.1
symbol: pfd-2
gene_biotype: protein_coding
description:
  Prefoldin subunit 2; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity); Belongs to the prefoldin subunit beta family.


ensembl_gene_id: H20J04.8.2
symbol: mog-2
gene_biotype: protein_coding
description:
  Probable U2 small nuclear ribonucleoprotein A; This protein is associated with sn-RNP U2. It helps the A' protein to bind stem loop IV of U2 snRNA. Required maternally for early embryonic development and zygotically for germline and somatic development. Has a role in the switch from mitosis to meiosis. Might function in alternative splicing.


ensembl_gene_id: H21P03.2.1
symbol: H21P03.2
gene_biotype: protein_coding
description:
  Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.


ensembl_gene_id: H21P03.3b.1
symbol: sms-1
gene_biotype: protein_coding
description:
  Phosphatidylcholine:ceramide cholinephosphotransferase 1; Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide.


ensembl_gene_id: H22K11.1.1
symbol: asp-3
gene_biotype: protein_coding
description:
  Aspartic protease 3; Aspartic protease (Probable). Part of the necrosis cell death pathway. Involved in neuronal cell degeneration. Involved in heat stress response.


ensembl_gene_id: H23L24.3b.1
symbol: ttll-11
gene_biotype: protein_coding
description:
  Tubulin polyglutamylase ttll-11; Polyglutamylase which preferentially modifies tubulin. Involved in the side-chain initiation step of the polyglutamylation reaction. By controlling tubulin glutamylation, regulates ciliary specialization and motor-based transport. Promotes the formation of A and B tubule singlets by splaying microtubule doublets in cilia. Together with ttll-4 and 5, required for male mating. [Isoform b]: Specifically promotes tubulin glutamylation in male ciliated CEM, HOB and RnB neurons that release bioactive extracellular vesicles. Regulates the localization of TRP c [...]


ensembl_gene_id: H23L24.5.1
symbol: parg-2
gene_biotype: protein_coding
description:
  Poly(ADP-ribose) glycohydrolase 2; Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. Poly(ADP-ribose) metabolism may be required for maintenance of the normal function of neuronal cells (By similarity).


ensembl_gene_id: H24K24.3b.1
symbol: H24K24.3
gene_biotype: protein_coding
description:
  Alcohol dehydrogenase class-3; Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione (By similarity). Plays a role in the calcium flux to the cytoplasm in the ASJ sensory neurons upon removal of a nitric oxide stimulus.


ensembl_gene_id: H24K24.4a.1
symbol: trm-2A
gene_biotype: protein_coding
description:
  RRM domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.


ensembl_gene_id: H25P06.2b.1
symbol: cdk-9
gene_biotype: protein_coding
description:
  Probable cyclin-dependent kinase 9; Essential member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (C- terminal domain) of the large subunit of RNA polymerase II (RNAP II) and spt-5.


ensembl_gene_id: H27M09.2.1
symbol: rpb-5
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerases I, II, and III subunit RPABC1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RPB5 is part of the lower  [...]


ensembl_gene_id: H27M09.3.1
symbol: syp-4
gene_biotype: protein_coding
description:
  Synaptonemal complex protein 4; Constitutes an element of the transverse filaments of the synaptonemal complex (SC), formed between homologous chromosomes during meiotic prophase I, and is required for the assembly of the central region of the SC. Required for chromosome synapsis and chiasma formation between homologous chromosomes during meiosis, mechanisms that are crucial for crossover formation and meiotic recombination.


ensembl_gene_id: H28G03.6.1
symbol: mtm-5
gene_biotype: protein_coding
description:
  Myotubularin-related protein 5; Probably acts as an adapter for other myotubularin-like phosphatases (Probable); Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily.


ensembl_gene_id: H28O16.1a.2
symbol: atp-1
gene_biotype: protein_coding
description:
  ATP synthase subunit alpha, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the  [...]


ensembl_gene_id: H35N03.1.1
symbol: exp-1
gene_biotype: protein_coding
description:
  Gamma-aminobutyric acid receptor exp-1; GABA receptor that functions as an excitatory cation channel. Permeable to monovalent cations such as Na(+) and K(+). Has negligible divalent cation permeability. Does not act as a chloride channel. Mediates enteric muscle contractions required for defecation. Probably by regulating the defecation motor program, required for fatty acid uptake by intestinal cells.


ensembl_gene_id: H38K22.2a.1
symbol: dcn-1
gene_biotype: protein_coding
description:
  Defective in cullin neddylation protein 1; Required for neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity. Does not act by preventing deneddylation, but rather facilitates neddylation, possibly by acting with rbx-1 to recruit the Nedd8-charged E2 enzyme to the cullin component of SCF-type complexes.


ensembl_gene_id: H38K22.5a.2
symbol: gly-6
gene_biotype: protein_coding
description:
  Probable N-acetylgalactosaminyltransferase 6; Probable glycopeptide transferase involved in O-linked oligosaccharide biosynthesis. Glycopeptide transferases catalyze the transfer of an N-acetyl-D-galactosamine residue to an already glycosylated peptide (By similarity). In contrast to other members of the family, it does not act as a peptide transferase that transfers GalNAc onto serine or threonine residue on peptides that have been tested. Some peptide transferase activity is however not excluded, considering that its appropriate peptide substrate may remain unidentified.


ensembl_gene_id: H39E23.1d.1
symbol: par-1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase par-1; Required for cytoplasmic partitioning and asymmetric cell division in early embryogenesis. Phosphorylates and restricts the asymmetry effector mex-5 (and possibly also mex-6) to the anterior cytoplasm of the zygote. Regulates mes-1 expression during early embryogenesis. Critical role in postembryonic vulval morphogenesis. Involved in the establishment of neuronal polarity.


ensembl_gene_id: H42K12.1b.1
symbol: pdk-1
gene_biotype: protein_coding
description:
  3-phosphoinositide-dependent protein kinase 1; Involved in the daf-2/insulin receptor-like transduction pathway, which controls longevity and prevents developmental arrest at the dauer stage. Phosphorylates and activates sgk-1, akt-1 and akt-2. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.


ensembl_gene_id: JC8.10b.1
symbol: unc-26
gene_biotype: protein_coding
description:
  Synaptojanin; Probable inositol 5-phosphatase which regulates synaptic vesicle recycling in neurons by regulating clathrin-mediated endocytosis; In the central section; belongs to the inositol 1,4,5- trisphosphate 5-phosphatase family.


ensembl_gene_id: JC8.3a.1
symbol: rpl-12
gene_biotype: protein_coding
description:
  60S ribosomal protein L12; Binds directly to 26S ribosomal RNA; Belongs to the universal ribosomal protein uL11 family.


ensembl_gene_id: JC8.6a.1
symbol: lin-54
gene_biotype: protein_coding
description:
  Protein lin-54; Synthetic multivulva class B (synMuvB) protein. SynMuvB proteins are required to repress the induction of vulval development by Ras signaling and probably act by forming the multiprotein DRM complex that repress transcription; Belongs to the lin-54 family.


ensembl_gene_id: K01B6.1.1
symbol: fozi-1
gene_biotype: protein_coding
description:
  Formin-homology and zinc finger domains protein 1; Acts redundantly with hlh-1 to promote body wall muscle cell and coelomocyte specification in postembryonic mesoderm progenitors, probably through suppression of sem-2; Belongs to the formin homology family.


ensembl_gene_id: K01C8.10.1
symbol: cct-4
gene_biotype: protein_coding
description:
  T-complex protein 1 subunit delta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.


ensembl_gene_id: K01C8.3b.1
symbol: tdc-1
gene_biotype: protein_coding
description:
  Tyrosine decarboxylase; Required for the decarboxylation of tyrosine to tyramine, a precursor of octopamine but probably also itself a neurotransmitter. Involved in the regulation of egg laying, which is inhibited by tyramine. Also involved in controlling locomotion and head movements. Due to its involvement in octopamine biosynthesis, also required for crtc-1-dependent regulation of AMPK-mediated longevity which requires octopamine signaling ; Belongs to the group II decarboxylase family.


ensembl_gene_id: K01C8.9.2
symbol: nst-1
gene_biotype: protein_coding
description:
  Guanine nucleotide-binding protein-like 3 homolog; May play a role in regulating cellular proliferation in both germline and somatic tissues.


ensembl_gene_id: K01G5.1.1
symbol: rnf-113
gene_biotype: protein_coding
description:
  Probable E3 ubiquitin-protein ligase rnf113; May function as E3 ubiquitin-protein ligase that catalyzes the transfer of ubiquitin onto target proteins. May play a role in DNA repair via its role in the synthesis of 'Lys-63'-linked polyubiquitin chains that recruit proteins involved in repair to sites of DNA damage by alkylating agents.


ensembl_gene_id: K01G5.4.1
symbol: ran-1
gene_biotype: protein_coding
description:
  GTP-binding nuclear protein ran-1; Ran GTPase system comprises ran-1, ran-2 and ran-3 and is essential in nucleocytoplasmic transport. Ran-1 is a GTP-binding protein that mediates the interaction between mitotic chromosomes and kinetochore microtubules. Plays a crucial role in nuclear envelope assembly at the end of each cell division. Required for the import of protein into the nucleus and also for RNA export. RCC1 (ran-3)/Ran (ran-1) complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA.


ensembl_gene_id: K01G5.5.1
symbol: K01G5.5
gene_biotype: protein_coding
description:
  Putative H/ACA ribonucleoprotein complex subunit 4; Plays a central role in ribosomal RNA processing. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity); Belongs to the pseudouridine synthase TruB family.


ensembl_gene_id: K01G5.6.2
symbol: rib-2
gene_biotype: protein_coding
description:
  Exostosin-2 homolog; Glycosyltransferase required for the biosynthesis of heparan sulfate. Initiates heparan sulfate synthesis by transferring GlcNAc to the (GlcA-Gal-Gal- Xyl-)Ser core linker (GlcNAcT-I activity). In association with rib-1, is also responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains (GlcNAcT-II and GlcAT-II activities). Required for normal ventral epidermal enclosure during the early stages of embryonic development. In addition, involved in the elon [...]


ensembl_gene_id: K01H12.1a.1
symbol: dph-3
gene_biotype: protein_coding
description:
  DPH3 homolog; Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2 (By similarity).


ensembl_gene_id: K01H12.2.1
symbol: ant-1.3
gene_biotype: protein_coding
description:
  Mitochondrial adenine nucleotide translocase 1.3; Belongs to the mitochondrial carrier (TC 2.A.29) family.


ensembl_gene_id: K02A2.3b.1
symbol: kcc-3
gene_biotype: protein_coding
description:
  Potassium/chloride cotransporter 3; Probable potassium/chloride cotransporter that functions in the amphid sheath glial cells to regulate thermotaxis behavior. By maintaining chloride homeostasis, negatively regulates guanylate cyclase gcy-8 in the thermosensory AFD neurons and thereby controls the microvilli receptive ending morphology of the AFD neurons and thermotaxis. Modulates the temperature-evoked neuronal activity of the AFD neurons such as calcium responses to temperature gradients. Might also play a role in the chemotaxis behavior mediated by the sensory neurons AWA and AWC.


ensembl_gene_id: K02A4.1.1
symbol: bcat-1
gene_biotype: protein_coding
description:
  Branched-chain-amino-acid aminotransferase, cytosolic; Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.


ensembl_gene_id: K02A4.2.3
symbol: gpc-1
gene_biotype: protein_coding
description:
  Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.


ensembl_gene_id: K02B12.1.1
symbol: ceh-6
gene_biotype: protein_coding
description:
  Homeobox protein ceh-6; Vital for embryonic development and essential for the proper function of the excretory cell. Required for the transdifferentiation of the Y rectal epithelial cell to the PDA motor neuron during larval development.


ensembl_gene_id: K02B12.4b.1
symbol: axl-1
gene_biotype: protein_coding
description:
  Axin-like protein 1; Works in parallel with pry-1 in negatively regulating bar-1 signaling in vulval precursor cells and Q neuroblasts. Shown to have a role in excretory cell development.


ensembl_gene_id: K02B2.1.1
symbol: pfkb-1.2
gene_biotype: protein_coding
description:
  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase; Synthesis and degradation of fructose 2,6-bisphosphate.


ensembl_gene_id: K02B2.3.1
symbol: mcu-1
gene_biotype: protein_coding
description:
  Calcium uniporter protein, mitochondrial; Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes a pore- forming and calcium-conducting subunit (By similarity). Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways (By similarity). Required for rapid mitochondrial calcium uptake and mitochondrial reactive oxygen species (mtROS) production after wounding.


ensembl_gene_id: K02D10.5.1
symbol: snap-29
gene_biotype: protein_coding
description:
  Soluble NSF attachment protein 29; SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion; Belongs to the SNAP-25 family.


ensembl_gene_id: K02D7.1b.1
symbol: K02D7.1
gene_biotype: protein_coding
description:
  Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.


ensembl_gene_id: K02D7.5.1
symbol: swt-1
gene_biotype: protein_coding
description:
  Sugar transporter SWEET1; Mediates both low-affinity uptake and efflux of sugar across the membrane; Belongs to the SWEET sugar transporter family.


ensembl_gene_id: K02E10.8b.1
symbol: syg-1
gene_biotype: protein_coding
description:
  Synaptogenesis protein syg-1; Cell adhesion protein. Involved in synapse formation in the HSNL egg-laying motor neuron. Inhibits assembly of the SCF(sel-10) E3 ubiquitin ligase complex at synapses, and protects them from elimination. Also required for F- actin assembly at the synaptic region and for axon branch formation.


ensembl_gene_id: K02F2.2.2
symbol: ahcy-1
gene_biotype: protein_coding
description:
  Adenosylhomocysteinase; Adenosylhomocysteine is a competitive inhibitor of S- adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.


ensembl_gene_id: K02F3.10.1
symbol: moma-1
gene_biotype: protein_coding
description:
  MICOS complex subunit MIC27; Sustains mitochondrial morphology probably through maintaining cristae morphology. May act as a component of the MICOS complex, a large protein complex of the mitochondria (By similarity).


ensembl_gene_id: K02F3.12a.1
symbol: K02F3.12
gene_biotype: protein_coding
description:
  Putative ATP-dependent DNA helicase Q1; DNA helicase that may play a role in the repair of DNA that is damaged by ultraviolet light or other mutagens. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction (By similarity). Belongs to the helicase family. RecQ subfamily.


ensembl_gene_id: K02F3.2b.1
symbol: K02F3.2
gene_biotype: protein_coding
description:
  Probable calcium-binding mitochondrial carrier K02F3.2; Mitochondrial and calcium-binding carrier that catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane.


ensembl_gene_id: K02F3.6.1
symbol: ceeh-1
gene_biotype: protein_coding
description:
  Epoxide hydrolase 1; Catalyzes the hydrolysis of epoxide-containing fatty acids. Active in vitro against trans-1,3-diphenylpropene oxide (t-DPPO), epoxyeicosatrienoic acids (EETs) including 8,9-EET, 11,12-EET and 14,15-EET and the linoleic acid metabolites 12,13-epoxy-9-octadecenoate (12,13-EpOME) and 9,10-epoxy-12-octadecenoate (9,10-EpOME). Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.


ensembl_gene_id: K02G10.4a.1
symbol: flp-11
gene_biotype: protein_coding
description:
  FMRFamide-like neuropeptides 11; FMRFamides and FMRFamide-like peptides are neuropeptides.  [ASGGMRNALVRF-amide]: Acts as a ligand for the npr-22 receptor in vitro; Belongs to the FARP (FMRFamide related peptide) family.


ensembl_gene_id: K02G10.6.1
symbol: hyl-2
gene_biotype: protein_coding
description:
  Ceramide synthase hyl-2; Catalyzes the acylation of sphingosine to form ceramides. Exhibits substrate preference for fatty acyl-coA chains containing 20 and 22 carbons. Required for adaptation of the nematode to anoxia. Anoxia tolerance may require one or more of the ceramide species that are either specifically or preferentially synthesized by hyl-2, and seems to be effected by a pathway that is parallel to that involving daf-2.


ensembl_gene_id: K03A1.5.2
symbol: sur-5
gene_biotype: protein_coding
description:
  Acetoacetyl-CoA synthetase; Activates acetoacetate to acetoacetyl-CoA (By similarity). Negatively regulates let-60 Ras activity during vulval induction. Belongs to the ATP-dependent AMP-binding enzyme family.


ensembl_gene_id: K03B4.3b.3
symbol: taf-10
gene_biotype: protein_coding
description:
  Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family.


ensembl_gene_id: K03B8.9.1
symbol: deg-3
gene_biotype: protein_coding
description:
  Acetylcholine receptor subunit alpha-type deg-3; Subunit of the non-synaptic neuronal acetylcholine receptor, which may play a role in chemotaxis towards choline. After binding choline or acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion- conducting channel across the plasma membrane ; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.


ensembl_gene_id: K03D3.10.1
symbol: rac-2
gene_biotype: protein_coding
description:
  Ras-related protein rac-2; During gonad morphogenesis, plays a role in distal tip cell (DTC)-mediated guidance of gonad elongation.


ensembl_gene_id: K03E5.3a.1
symbol: cdk-2
gene_biotype: protein_coding
description:
  Cyclin-dependent kinase 2; Serine/threonine-protein kinase which, in association with cye-1, regulates proliferation, quiescent state and cell fate during the development of several cell lineages. . In the embryo, initiates the establishment of cell polarity through the recruitment of the centrosomal proteins spd-2 and spd-5 during prophase. Phosphorylation and inhibition of the translational repressor gld-1 by the cdk-2/cye-1 complex regulates the pool of germline stem cells and the size of the mitotic zone in the gonads by preventing entry into meiosis.


ensembl_gene_id: K03E6.6.1
symbol: pfn-3
gene_biotype: protein_coding
description:
  Profilin-3; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Also binds to poly(L-proline) and phosphatidylinositol 4,5-bisphosphate micelles.


ensembl_gene_id: K03E6.7.1
symbol: rei-2
gene_biotype: protein_coding
description:
  Guanine nucleotide exchange factor rei-2; Guanine nucleotide exchange factor for Rab GTPase Rab-11.1 (By similarity). May spatially and temporally regulate the distribution of Rab-11.1 to target membranes during embryogenesis. May play a role in cytokinesis, probably by targeting rab-11.1 to the cleavage furrows ; Belongs to the SH3BP5 family.


ensembl_gene_id: K03F8.2.1
symbol: acr-5
gene_biotype: protein_coding
description:
  Acetylcholine receptor subunit alpha-type acr-5; Possible acetylcholine receptor; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.


ensembl_gene_id: K03H1.2.2
symbol: mog-1
gene_biotype: protein_coding
description:
  Probable pre-mRNA-splicing factor ATP-dependent RNA helicase mog-1; Probable ATP-binding RNA helicase involved in pre-mRNA splicing; Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily.


ensembl_gene_id: K03H9.2.1
symbol: col-75
gene_biotype: protein_coding
description:
  Putative cuticle collagen 75; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment (By similarity).


ensembl_gene_id: K04A8.6b.1
symbol: dre-1
gene_biotype: protein_coding
description:
  F-box protein dre-1; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins including blmp-1. Heterochronic protein which is required for the timing of gonad development and epidermal seam cell differentiation. Regulates tail-spike cell death through inhibition of the apoptosis regulator ced-9.


ensembl_gene_id: K04B12.1.1
symbol: plx-2
gene_biotype: protein_coding
description:
  Plexin-2; Involved as a receptor for mab-20/sema-2a in the formation or stabilization of cell-cell contacts at several stages of epithelial morphogenesis. In early embryonic development, required for proper ventral closure of the epidermis. During male tail morphogenesis, involved in precursor cell sorting and in the formation of distinct sensory rays. Involved in axon guidance of SDQL neurons during neurogenesis. Probably in response to stimulation by mab-20, regulates fln-1-mediated remodeling of the actin cytoskeleton and thus axon guidance and/or fasciculation of DD/VD neurons. Bel [...]


ensembl_gene_id: K04B12.3a.1
symbol: smg-8
gene_biotype: protein_coding
description:
  Protein smg-8; Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Probable component of kinase complex containing smg-1 and recruited to stalled ribosomes. Belongs to the SMG8 family.


ensembl_gene_id: K04C2.4.2
symbol: brd-1
gene_biotype: protein_coding
description:
  BRCA1-associated RING domain protein 1; Involved in ubiquitination. Constituent of the CeBCD complex that possesses E3 ubiquitin-protein ligase activity. Involved in DNA repair. Has a reactive role in the response to DNA damage by ionizing radiation. Protects against chromosome non-disjunction and fragmentation to aid chromosome stability.


ensembl_gene_id: K04D7.1.3
symbol: rack-1
gene_biotype: protein_coding
description:
  Guanine nucleotide-binding protein subunit beta-2-like 1; Required for the expression of antimicrobial peptide nlp-29 in response to fungal infection or physical injury.


ensembl_gene_id: K04E7.2.1
symbol: pept-1
gene_biotype: protein_coding
description:
  Peptide transporter family 1; Low-affinity peptide transporter that is necessary for proton-dependent uptake of di- or tripeptides, and to a minor extent tetrapeptides, in the intestine. Transport is independent of sodium and chloride ions. Controls the uptake of dietary fatty acids, plays a role in fatty acid synthesis and is responsible for dipeptide-induced acidification of the intestine. Regulates cellular pH differences together with the antiporter protein, nhx-2. Amino acid uptake and absorption levels influence the insulin signaling/daf-2 and let-363/TOR pathways, subsequently a [...]


ensembl_gene_id: K04F10.2.1
symbol: K04F10.2
gene_biotype: protein_coding
description:
  Protein KIAA0556 homolog; May regulate ciliary A-tubule number and, along with arl-13, controls cilium integrity.


ensembl_gene_id: K04F10.4d.1
symbol: bli-4
gene_biotype: protein_coding
description:
  Endoprotease bli-4; Serine endoprotease which cleaves proproteins at paired basic amino acids (Probable). Involved in cuticle biosynthesis probably by cleaving pro-collagen into its mature form. Acts in ASEL sensory neurons to regulate high salt chemotaxis responses probably by cleaving insulin-like protein ins-6 into its mature and active form. Essential for embryonic and larval development. isoform a, isoform e, isoform f, isoform g and isoform h are involved in cuticle biosynthesis but are dispensable for larval development.


ensembl_gene_id: K04G11.4.1
symbol: wdr-5.2
gene_biotype: protein_coding
description:
  WD repeat-containing protein wdr-5.2; Sex determining protein required in the germline to promote the spermatogenesis to oogenesis switch during the late larval stages of development. Acts with the sex determining factor tra-1, and redundantly with wdr-5.1, to regulate fog-3 expression, which in turn determines germ cell fate. Not required for methylation of histone H3 'Lys-4'.


ensembl_gene_id: K04G2.1.2
symbol: eif-2beta
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 2 subunit 2; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyz [...]


ensembl_gene_id: K04G2.2.1
symbol: aho-3
gene_biotype: protein_coding
description:
  Alpha/beta hydrolase domain-containing protein aho-3; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins (By similarity). Acts in sensory neurons including AWC to regulate starvation-induced thermotaxis plasticity and salt learning behavior; Belongs to the AB hydrolase superfamily. ABHD17 family.


ensembl_gene_id: K04G2.3.1
symbol: cdc-48.3
gene_biotype: protein_coding
description:
  ATPase family protein 2 homolog; ATP-dependent chaperone which uses the energy provided by ATP hydrolysis to generate mechanical force to disassemble protein complexes (By similarity). Required for various steps of embryonic mitosis including centrosome duplication, spindle assembly, ER dynamics and cell cycle progression. Regulates the stability and activity of kinase air-2, a component of the chromosomal passenger complex (CPC). Inhibits air-2 kinase activity from metaphase to late telophase and negatively regulates air-2 stability during mitotic exit. Controls ER transition into she [...]


ensembl_gene_id: K04G2.8b.1
symbol: apr-1
gene_biotype: protein_coding
description:
  Adenomatous polyposis coli protein-related protein 1; Has a role in endoderm cell specification and pharyngeal development. Required for the migration of epithelial cells, organization of the anterior seam cells and ceh-13 expression during embryo morphogenesis. Prevents hyperactivation of the Wnt signaling pathway during endoderm development, probably by preventing hmp-2 nuclear translocation. During larval development, apr-1 is required for expression of lin-39 in P3-8.p. Shown to negatively regulate Wnt signaling in vulval precursor cells. Has a role in cell division by establishing [...]


ensembl_gene_id: K04G7.3a.2
symbol: ogt-1
gene_biotype: protein_coding
description:
  UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase; Addition of nucleotide-activated sugars directly onto the polypeptide through O-glycosidic linkage with the hydroxyl of serine or threonine.


ensembl_gene_id: K04G7.4a.1
symbol: nuo-4
gene_biotype: protein_coding
description:
  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.


ensembl_gene_id: K04H4.1a.1
symbol: emb-9
gene_biotype: protein_coding
description:
  Collagen alpha-1(IV) chain; Collagen type IV is specific for basement membranes (Probable). Required to restrict presynaptic growth at the neuromuscular junctions (NMJ) in late larval stage and in adult motor neurons. May play a role in axon regeneration in embryos following injury in D-type motor neurons.


ensembl_gene_id: K04H4.6b.1
symbol: crn-6
gene_biotype: protein_coding
description:
  Cell death-related nuclease 6; Involved in the degradation of chromosomal DNA. Contributes to cell killing; Belongs to the DNase II family.


ensembl_gene_id: K05B2.3.1
symbol: ifa-4
gene_biotype: protein_coding
description:
  Intermediate filament protein ifa-4; Cytoplasmic intermediate filaments provide mechanical strength to cells. Non-essential protein.


ensembl_gene_id: K05C4.1.1
symbol: pbs-5
gene_biotype: protein_coding
description:
  Proteasome subunit pbs-5; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles (By similarity). Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins (By similarity). The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular funct [...]


ensembl_gene_id: K05C4.6b.1
symbol: hmp-2
gene_biotype: protein_coding
description:
  Beta-catenin-like protein hmp-2; Required for cell migration during body enclosure and cell shape changes during body elongation. Plays a role in recruitment of the cadherin protein hmr-1 to adherens junctions.


ensembl_gene_id: K05F1.7.1
symbol: msp-63
gene_biotype: protein_coding
description:
  Major sperm protein 63; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.


ensembl_gene_id: K06A1.1.1
symbol: aptf-1
gene_biotype: protein_coding
description:
  Transcription factor aptf-1; Transcription factor, which is required in the single sleep- active ring interneuron RIS for sleep-like behavioral quiescence induced by neuropeptide signaling in larvae. Regulates gene expression of sleep-inducing FMRFamide-like neuropeptide flp-11 in RIS.


ensembl_gene_id: K06A1.5.1
symbol: atg-16.2
gene_biotype: protein_coding
description:
  Autophagic-related protein 16.2; Most likely a component of the atg-5-atg-12-atg-16.1/atg-16.2 complex, which is recruited to the preautophagosomal membrane and associates with lgg-2 to promote autophagosome formation. Plays a role in the recruitment of lipidated lgg-1 probably to the autophagosome membrane to promote autophagosome formation. Furthermore, association with atg-5 is required for the nucleation of lgg-1 positive autophagosomes. Although its role in autophagosome formation may be distinct to the role of atg-16.2, it functions in a partially redundant manner with atg-16.1 t [...]


ensembl_gene_id: K06A4.3.1
symbol: gsnl-1
gene_biotype: protein_coding
description:
  Gelsolin-like protein 1; Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). Binds actin but does not nucleate actin polymerization, albeit slows down elongation by blocking the barbed ends. By promoting actin depolymerization, required for the elimination of presynaptic components downstream of the egl-1, ced-4 and ced-3 apoptotic pathway during larval development. Belongs to the villin/gelsolin family.


ensembl_gene_id: K06A4.5.1
symbol: haao-1
gene_biotype: protein_coding
description:
  3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.


ensembl_gene_id: K06A5.4.1
symbol: knl-2
gene_biotype: protein_coding
description:
  Kinetochore null protein 2; Required for the recruitment of hcp-3, hcp-4, knl-1, bub-1 and lin-53 to kinetochores, kinetochore assembly, chromosome condensation and chromosome segregation in meiosis and mitosis.


ensembl_gene_id: K06B4.1.1
symbol: nhr-51
gene_biotype: protein_coding
description:
  Nuclear hormone receptor family member nhr-51; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family.


ensembl_gene_id: K06B4.10.1
symbol: nhr-199
gene_biotype: protein_coding
description:
  Nuclear hormone receptor family member nhr-199; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family.


ensembl_gene_id: K06B4.11.1
symbol: nhr-53
gene_biotype: protein_coding
description:
  Nuclear hormone receptor family member nhr-53; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family.


ensembl_gene_id: K06B4.2.1
symbol: nhr-52
gene_biotype: protein_coding
description:
  Nuclear hormone receptor family member nhr-52; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family.


ensembl_gene_id: K06B4.6.2
symbol: nhr-268
gene_biotype: protein_coding
description:
  Nuclear hormone receptor family member nhr-268; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family.


ensembl_gene_id: K06B4.7.1
symbol: nhr-197
gene_biotype: protein_coding
description:
  Nuclear hormone receptor family member nhr-197; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family.


ensembl_gene_id: K06H7.3.3
symbol: vms-1
gene_biotype: protein_coding
description:
  Protein vms-1; Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway. Component of an evolutionarily conserved system for ubiquitin-mediated mitochondria-associated protein degradation (MAD) (By similarity). Dispensable for viability and growth but is required for protection against oxidative stress and for wild- type life span.


ensembl_gene_id: K06H7.4.1
symbol: grp-1
gene_biotype: protein_coding
description:
  GTP exchange factor for ARFs 1; Promotes guanine-nucleotide exchange on ARF. Promotes the activation of ARF through replacement of GDP with GTP (By similarity). Plays a role in cell shedding during embryogenesis, probably by promoting the endocytosis of cell adhesion molecules.


ensembl_gene_id: K06H7.6.1
symbol: apc-2
gene_biotype: protein_coding
description:
  Anaphase-promoting complex subunit 2; Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins. Developmental role in early embryogenesis and the metaphase to anaphase transition in meiosis and mitosis.


ensembl_gene_id: K06H7.8.1
symbol: K06H7.8
gene_biotype: protein_coding
description:
  Putative serine/threonine-protein kinase K06H7.1; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.


ensembl_gene_id: K07A1.11.1
symbol: rba-1
gene_biotype: protein_coding
description:
  Probable histone-binding protein rba-1; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA (By similarity). Plays a role in regulating cell cycle progression. Required to repress the induction of vulval development by Ras signaling. In association with the zinc finger protein ztf-11, negatively regulates the expression of non- neuronal genes during neurogenesis. Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.


ensembl_gene_id: K07A1.12.1
symbol: lin-53
gene_biotype: protein_coding
description:
  Probable histone-binding protein lin-53; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA (By similarity). Required for hcp-3 and his-1 stabilization, localization of hcp-3 to centromeres and for proper chromosome segregation. Synthetic multivulva class B (synMuvB) protein. SynMuvB proteins are required to repress the induction of vulval development by Ras signaling and probably act by forming the multiprotein DRM complex that repres [...]


ensembl_gene_id: K07A1.9a.1
symbol: ate-1
gene_biotype: protein_coding
description:
  Arginyl-tRNA--protein transferase 1; Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Belongs to the R-transferase family.


ensembl_gene_id: K07A12.2.1
symbol: egg-6
gene_biotype: protein_coding
description:
  Leucine-rich repeat-containing protein egg-6; Required for apical extracellular matrix organization and epithelial junction maintenance.


ensembl_gene_id: K07A12.3.1
symbol: asg-1
gene_biotype: protein_coding
description:
  Probable ATP synthase subunit g 1, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism  [...]


ensembl_gene_id: K07A9.2.1
symbol: cmk-1
gene_biotype: protein_coding
description:
  Calcium/calmodulin-dependent protein kinase type 1; Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade which results in transcriptional activation. Transcriptional activation occurs at least in part through phosphorylation of crh-1. Regulates gene expression, sensory morphology, and function of the AFD thermosensory neurons. Involved in long-term adaptation of AFD neurons to temperatures warmer than the initial acclimatized cultivation temperature. Acts in the FLP thermal nociceptors to moderate the responsiveness to noxious [...]


ensembl_gene_id: K07B1.1.3
symbol: try-5
gene_biotype: protein_coding
description:
  Trypsin-like protease try-5; Serine protease which, in males, acts as a promoting signal during mating to activate sperm.


ensembl_gene_id: K07B1.2.1
symbol: coq-6
gene_biotype: protein_coding
description:
  Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6; Belongs to the UbiH/COQ6 family.


ensembl_gene_id: K07B1.3.1
symbol: ucp-4
gene_biotype: protein_coding
description:
  UnCoupling Protein (Mitochondrial substrate carrier); Belongs to the mitochondrial carrier (TC 2.A.29) family.


ensembl_gene_id: K07C11.5.2
symbol: cri-2
gene_biotype: protein_coding
description:
  Putative metalloproteinase inhibitor tag-225; Complexes with metalloproteinases and irreversibly inactivates them by binding to their catalytic zinc cofactor. Belongs to the protease inhibitor I35 (TIMP) family.


ensembl_gene_id: K07C5.1.1
symbol: arx-2
gene_biotype: protein_coding
description:
  Actin-related protein 2; Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (By similarity).


ensembl_gene_id: K07C5.4.1
symbol: nol-56
gene_biotype: protein_coding
description:
  Nucleolar protein 56; Required for 60S ribosomal subunit synthesis. Belongs to the NOP5/NOP56 family.


ensembl_gene_id: K07C5.5.1
symbol: ceeh-2
gene_biotype: protein_coding
description:
  Epoxide hydrolase 2; Catalyzes the hydrolysis of epoxide-containing fatty acids. Active in vitro against trans-1,3-diphenylpropene oxide (t-DPPO), epoxyeicosatrienoic acids (EETs) including 8,9-EET, 11,12-EET and 14,15-EET and the linoleic acid metabolites 12,13-epoxy-9-octadecenoate (12,13-EpOME) and 9,10-epoxy-12-octadecenoate (9,10-EpOME). Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.


ensembl_gene_id: K07C5.6.1
symbol: K07C5.6
gene_biotype: protein_coding
description:
  Pre-mRNA-splicing factor SLU7; Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Belongs to the SLU7 family.


ensembl_gene_id: K07C5.7.1
symbol: ttll-15
gene_biotype: protein_coding
description:
  Probable tubulin polyglutamylase ttll-15; Probable polyglutamylase that forms polyglutamate side chains on tubulin. Probably acts when complexed with other proteins. Appears to be dispensable for polar spindle formation in dividing embryonic cells, for cilia-dependent osmotic avoidance and for male mating behavior. Regulates microtubule dynamics in uterine muscle cells. Belongs to the tubulin--tyrosine ligase family.


ensembl_gene_id: K07D4.3.1
symbol: rpn-11
gene_biotype: protein_coding
description:
  26S proteasome non-ATPase regulatory subunit 14; Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The function of the 'Lys-63'-specific deubiquitination of the proteasome is unclear (By similarity).


ensembl_gene_id: K07D8.1.1
symbol: mup-4
gene_biotype: protein_coding
description:
  Transmembrane matrix receptor MUP-4; Required for junctional attachments between hypodermis and muscle, and between the apical epithelial surface and the cuticular matrix. Essential for enclosure of the embryo by the hypodermis, hypodermal integrity, embryo elongation, and maintenance of hypodermal morphology in fully elongated embryos.


ensembl_gene_id: K07E1.1.2
symbol: K07E1.1
gene_biotype: protein_coding
description:
  1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase homolog 2; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene); Belongs to the acireductone dioxygenase (ARD) family.


ensembl_gene_id: K07E12.1a.2
symbol: dig-1
gene_biotype: protein_coding
description:
  Mesocentin; Encodes an adhesion molecule involved in sensory map formation. Functions during sensory process development in the nervous system.


ensembl_gene_id: K07E3.7b.1
symbol: catp-5
gene_biotype: protein_coding
description:
  Cation-transporting ATPase catp-5; Involved in the uptake and/or transport of polyamines, probably through ATP hydrolysis. This contributes to the maintenance of intracellular polyamine levels. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.


ensembl_gene_id: K07E3.8.2
symbol: vem-1
gene_biotype: protein_coding
description:
  Protein vem-1; Transmembrane protein required for the axon guidance of a subset of ventral nerve cord-associated interneurons and motor neurons. May function with the netrin receptor unc-40 in axon guidance.


ensembl_gene_id: K07H8.3.1
symbol: daf-31
gene_biotype: protein_coding
description:
  N-alpha-acetyltransferase daf-31; Catalytic subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity (By similarity). Plays a role in regulating larval development, metabolism and longevity. Functions downstream or alongside daf-3, daf-12 and daf-16 in the dauer formation pathway. Functions upstream of daf-15 to enable animal development.


ensembl_gene_id: K07H8.6c.1
symbol: vit-6
gene_biotype: protein_coding
description:
  Vitellogenin-6; Precursor of the egg-yolk proteins that are sources of nutrients during embryonic development (Probable). May play a role in cholesterol uptake. May be involved in thermotolerance.


ensembl_gene_id: K08A8.1a.1
symbol: mek-1
gene_biotype: protein_coding
description:
  Dual specificity mitogen-activated protein kinase kinase mek-1; Dual specificity protein kinase which may phosphorylate kgb-1 and thereby is an essential component of the JNK pathway composed of mlk-1, mek-1 and kgb-1. May also have a synergistic role with sek-1 in phosphorylating pmk-1. Involved in the response to environmental stress including heavy metal ions (Cu(2+) and Cd(2+)), oxidative stress and starvation. In association with sek-1, regulates germline cell apoptosis in response to oxidative, osmotic and heat shock stresses. Involved in resistance to pathogenic bacteria infecti [...]


ensembl_gene_id: K08A8.2a.2
symbol: sox-2
gene_biotype: protein_coding
description:
  Transcription factor sox-2; Probable transcription factor that regulates the lineage progression of embryonic blast cells and controls the postmitotic specification and differentiation of neurons. Cooperates with additional factors to direct the differentiation of the olfactory neurons, functioning with the transcription factor ceh-36 to specify AWC neurons and with the LIM homeodomain factor lim-4 to suppress AWC terminal differentiation and promote AWB neuron differentiation. Plays a role in the terminal differentiation of glutamatergic and cholinergic neurons. Required for natural r [...]


ensembl_gene_id: K08B12.5a.2
symbol: mrck-1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase mrck-1; Serine/threonine-protein kinase that may phosphorylate and inactivate the phosphatase mel-11, and thereby contribute to the regulation of myosin II contractility during embryonic elongation. Involved in controlling canal length and Golgi/ER integrity during excretory canal elongation.


ensembl_gene_id: K08B4.6.1
symbol: cpi-1
gene_biotype: protein_coding
description:
  Cystatin cpi-1; Cysteine protease inhibitor which inhibits members of the peptidase C1 family. Does not inhibit asparaginyl endopeptidase. May play a protective role against exogenous cysteine proteases derived from soil bacteria or fungi, or rotting fruits and vegetation. Belongs to the cystatin family.


ensembl_gene_id: K08C7.3f.1
symbol: epi-1
gene_biotype: protein_coding
description:
  Laminin-like protein epi-1; During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles, probably downstream of the integrin complex formed by pat-2 and pat-3.


ensembl_gene_id: K08D12.2.1
symbol: rpi-2
gene_biotype: protein_coding
description:
  Protein XRP2; Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization.


ensembl_gene_id: K08D9.3a.1
symbol: apx-1
gene_biotype: protein_coding
description:
  Anterior pharynx in excess protein 1; Involved in the specification of the blastomere cell ABP fate. Contributes to the establishment of the dorsal-ventral axis in the early embryo.


ensembl_gene_id: K08E3.3b.1
symbol: toca-2
gene_biotype: protein_coding
description:
  Transducer of Cdc42-dependent actin assembly protein 2 homolog; Plays a role in protein trafficking, actin organization and embryonic morphogenesis. Potentially acts as cdc-42 effector. May play a role in egg laying. Together with toca-1, is required for protein trafficking regulating yolk protein clathrin-mediated endocytosis by oocytes during oogenesis and retrograde recycling and the sorting of recycling endosome cargo proteins such as mig-14. Also, together with toca-2, controls the distribution of actin at cell junctions. Belongs to the FNBP1 family.


ensembl_gene_id: K08E3.7a.2
symbol: pdr-1
gene_biotype: protein_coding
description:
  E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.


ensembl_gene_id: K08E3.8.1
symbol: mdt-29
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 29; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).


ensembl_gene_id: K08E4.1.2
symbol: spt-5
gene_biotype: protein_coding
description:
  Transcription elongation factor SPT5; May function as a component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II. DSIF may enhance transcriptional pausing at sites proximal to the promoter, which may in turn facilitate the assembly of an elongation competent RNA polymerase II complex. Belongs to the SPT5 family.


ensembl_gene_id: K08E5.2a.1
symbol: nac-3
gene_biotype: protein_coding
description:
  Sodium-dependent high-affinity dicarboxylate transporter 3; High-affinity sodium-dicarboxylate cotransporter that accepts a range of tricarboxylic acid-cycle intermediates with 4-5 carbon atoms. There is no interaction with monocarboxylates. Plays a role in the regulation of life span.


ensembl_gene_id: K08E5.3a.1
symbol: mua-3
gene_biotype: protein_coding
description:
  Transmembrane cell adhesion receptor mua-3; Involved in cell adhesion and required for organ positioning and attachment. At the hypodermal surface, required for attachment of the hypdermermis to the basal cuticle in postembryonic development, possibly through intermediate filaments of the cytoskeleton.


ensembl_gene_id: K08E7.3.1
symbol: let-99
gene_biotype: protein_coding
description:
  Protein let-99; Required for the proper orientation of spindles after the establishment of polarity. May play a role in interactions between the astral microtubules and the cortical cytoskeleton. Required for asymmetric forces on nuclei and spindles. Acts downstream of the PAR signaling as an intermediate that transduces polarity information to the machinery that positions the mitotic spindle, possibly by regulating force generation. Regulates gpr-1/2 asymmetric cortical localization during the first embryonic cell divisions. Acts antagonistically to the gpr-1/2 signaling pathway. Regu [...]


ensembl_gene_id: K08E7.7a.1
symbol: cul-6
gene_biotype: protein_coding
description:
  Cullin-6; Probable core component of cullin-based SCF-like E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins.


ensembl_gene_id: K08E7.9.1
symbol: pgp-1
gene_biotype: protein_coding
description:
  Multidrug resistance protein pgp-1; Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells; Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.


ensembl_gene_id: K08F11.3.1
symbol: cif-1
gene_biotype: protein_coding
description:
  COP9/Signalosome and eIF3 complex-shared subunit 1; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation (Potential). Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essen [...]


ensembl_gene_id: K08F11.5.1
symbol: miro-1
gene_biotype: protein_coding
description:
  Mitochondrial Rho GTPase 1; Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution.


ensembl_gene_id: K08F4.11.1
symbol: gst-3
gene_biotype: protein_coding
description:
  Glutathione S-transferase 3; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Belongs to the GST superfamily. Sigma family.


ensembl_gene_id: K08F4.3.1
symbol: K08F4.3
gene_biotype: protein_coding
description:
  Translocon-associated protein subunit beta; TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.


ensembl_gene_id: K08F4.6.1
symbol: gst-2
gene_biotype: protein_coding
description:
  Glutathione S-transferase 2; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Belongs to the GST superfamily. Sigma family.


ensembl_gene_id: K08F4.7.1
symbol: gst-4
gene_biotype: protein_coding
description:
  Glutathione S-transferase 4; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (By similarity). May play a role in the detoxification of reactive oxygen species produced during pathogenic bacterial infection.


ensembl_gene_id: K08F4.8.1
symbol: msp-38
gene_biotype: protein_coding
description:
  Major sperm protein 38; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.


ensembl_gene_id: K08F8.1a.2
symbol: mak-1
gene_biotype: protein_coding
description:
  MAP kinase-activated protein kinase mak-1; Serine/threonine-protein kinase which may play a role in body wall muscle contraction. May phosphorylate unc-22/twitchin. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.


ensembl_gene_id: K08F8.3.2
symbol: fut-1
gene_biotype: protein_coding
description:
  Alpha-(1,3)-fucosyltransferase fut-1; Preferentially catalyzes the addition of fucose in alpha 1-3 linkage to the first GlcNAc residue (with or without alpha 1,6-linked fucose), next to the peptide chains in N-glycans. Unlike in mammals, does not require the prior action of N-acetylglucosaminyltransferase I to generate complex N-glycans.


ensembl_gene_id: K08F8.4a.1
symbol: pah-1
gene_biotype: protein_coding
description:
  Phenylalanine-4-hydroxylase; Catalyzes the hydroxylation of L-phenylalanine to L-tyrosine. Catalyzes the hydroxylation of tryptophan to 5-hydroxy-L-tryptophan. Plays a role in the biosynthesis of a melanin-like cuticle pigment. Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.


ensembl_gene_id: K08F8.6.1
symbol: let-19
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 13; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Require [...]


ensembl_gene_id: K08H10.4.1
symbol: uda-1
gene_biotype: protein_coding
description:
  Nucleoside-diphosphatase uda-1; Hydrolyzes UDP and GDP but not any other nucleoside di-, mono- or triphosphates. May promote reglycosylation reactions involved in glycoproteins folding and quality control in the endoplasmic reticulum; Belongs to the GDA1/CD39 NTPase family.


ensembl_gene_id: K09A9.1.1
symbol: nipi-3
gene_biotype: protein_coding
description:
  Protein nipi-3; By regulating the up-regulation in the epidermis of antimicrobial peptides nlp-29 and nlp-31, plays a role in resistance to fungal infection.


ensembl_gene_id: K09A9.5.1
symbol: gas-1
gene_biotype: protein_coding
description:
  Probable NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).


ensembl_gene_id: K09B11.1a.2
symbol: pik-1
gene_biotype: protein_coding
description:
  Pelle-like serine/threonine-protein kinase pik-1; Through association with the adapter actl-1, may act downstream of the receptor complex composed of ilcr-1 and ilcr-2, which is a signaling complex that modulates neuronal activity and animal behavior in response to sensory neuron input.


ensembl_gene_id: K09C8.1.1
symbol: pbo-4
gene_biotype: protein_coding
description:
  Na(+)/H(+) exchanger protein 7; Na+/H+ exchanger which mediates the transient acidification of the coelomic space and plays a role in contraction of posterior body muscles during defecation. Probably by regulating the defecation motor program, required for fatty acid uptake by intestinal cells.


ensembl_gene_id: K09C8.4.1
symbol: lge-1
gene_biotype: protein_coding
description:
  Glycosyltransferase-like protein LARGE; Probable glycosyltransferase; Belongs to the glycosyltransferase 8 family.


ensembl_gene_id: K09F5.2.1
symbol: vit-1
gene_biotype: protein_coding
description:
  Vitellogenin-1; Precursor of the egg-yolk proteins that are sources of nutrients during embryonic development.


ensembl_gene_id: K10B2.1b.2
symbol: lin-23
gene_biotype: protein_coding
description:
  F-box/WD repeat-containing protein lin-23; Functions cell autonomously to negatively regulate cell cycle progression. Required to restrain cell proliferation in response to developmental cues. Probably recognizes and binds to some proteins and promotes their ubiquitination and degradation (By similarity).


ensembl_gene_id: K10B2.5.1
symbol: ani-2
gene_biotype: protein_coding
description:
  Anillin-like protein 2; Required to maintain the structure of the rachis, the central cytoplasmic core of the syncytial adult gonad. Failure to maintain the rachis leads to premature dissociation of oocytes and thereby impedes oogenesis.


ensembl_gene_id: K10B3.9.2
symbol: mai-1
gene_biotype: protein_coding
description:
  ATPase inhibitor mai-1, mitochondrial; Thought to be a regulatory component of the ATP-synthesizing complex in the mitochondria.


ensembl_gene_id: K10B4.6a.1
symbol: cwn-1
gene_biotype: protein_coding
description:
  Protein Wnt-1; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Binds receptor tyrosine kinase cam-1. Together with Wnt ligand cwn-2, regulates the migration of CAN, ALM, BDU and HSN neurons during embryogenesis, the migration of QL and QR neuroblast descendants during larval development, and polarity of ALM neurons. Also acts with the Wnt ligand egl-20 to direct HSN neuron migration. Acts  [...]


ensembl_gene_id: K10C3.2.1
symbol: ensa-1
gene_biotype: protein_coding
description:
  ENdoSulfine Alpha; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. Belongs to the endosulfine family.


ensembl_gene_id: K10C3.3.1
symbol: zig-1
gene_biotype: protein_coding
description:
  Zwei Ig domain protein zig-1; Probably not involved in maintaining the position of ASI and ASH head neuron cell bodies and ventral nerve cord axons of PVQ, PVP, RMEV, AVK and HSN neurons.


ensembl_gene_id: K10C3.6c.2
symbol: nhr-49
gene_biotype: protein_coding
description:
  Nuclear hormone receptor family member nhr-49; Orphan nuclear receptor. Regulates expression of lipid desaturase, fat-7 ; Belongs to the nuclear hormone receptor family.


ensembl_gene_id: K10C8.1.1
symbol: parn-1
gene_biotype: protein_coding
description:
  3'-5' exoribonuclease parn-1; Involved in transcriptome surveillance. Required for piwi- interacting RNAs (piRNAs) 3'-end trimming, which is important for both fertility and piRNA-directed gene silencing. Has 3' to 5' exonuclease activity in vitro.


ensembl_gene_id: K10C9.3.1
symbol: K10C9.3
gene_biotype: protein_coding
description:
  Ribonuclease T2 protein rnst-2; Probable endoribonuclease involved in the autophagy-mediated degradation of ribosomal RNA and ribosomal proteins in lysosomes.


ensembl_gene_id: K10D2.1a.1
symbol: hira-1
gene_biotype: protein_coding
description:
  Protein HIRA; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family.


ensembl_gene_id: K10D2.4.1
symbol: emb-1
gene_biotype: protein_coding
description:
  Anaphase-promoting complex subunit emb-1; Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins (By similarity). Developmental role in early embryogenesis and the metaphase to anaphase transition in meiosis and mitosis. May be required for germline proliferation. Required for male tail development and hermaphrodite vulva formation.


ensembl_gene_id: K10D2.6.2
symbol: emb-8
gene_biotype: protein_coding
description:
  NADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5; In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.


ensembl_gene_id: K10D2.7.1
symbol: K10D2.7
gene_biotype: protein_coding
description:
  Molybdopterin synthase sulfur carrier subunit; Acts as a sulfur carrier required for molybdopterin biosynthesis. Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group. In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. After interaction with MOCS2B, the sulfur is then transferred to precursor Z to form molybdopterin.


ensembl_gene_id: K10G6.1.1
symbol: lin-31
gene_biotype: protein_coding
description:
  Protein lin-31; Lin-31 regulates how vulval precursor cells choose their fate. It helps specify three alternative cell fates in vulval development.


ensembl_gene_id: K10G9.3b.1
symbol: pad-2
gene_biotype: protein_coding
description:
  GDP-fucose protein O-fucosyltransferase 2; Catalyzes the reaction that attaches fucose through an O- glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X(2,3)-S/T-C2-X(2)-G of thrombospondin type I repeats (TSRs) where C1 and C2 are the first and second cysteines of the repeat, respectively. O-fucosylates members of several protein families including the ADAMTS superfamily and the thrombosporin (TSP) and spondin families. Required for the proper secretion of ADAMTS family members such as ADAMSL1 and ADAMST13 (By similarity). Belongs to the glycos [...]


ensembl_gene_id: K10H10.2.2
symbol: cysl-2
gene_biotype: protein_coding
description:
  Bifunctional L-3-cyanoalanine synthase/cysteine synthase; Primarily catalyzes the formation of cyanoalanine and hydrogen sulfide from cysteine and hydrogen cyanide. Can also catalyze, although less efficiently, the formation of cyanoalanine and hydrogen sulfide from either S-sulfocysteine or O-acetylserine and hydrogen cyanide and the formation of cysteine from either S-sulfocysteine or O- acetylserine and hydrogen sulfide. By catalyzing the assimilation of cyanide produced by P.aeruginosa, mediates resistance to infection. Involved in fertility, growth and aging. Does not mediate surv [...]


ensembl_gene_id: K11B4.2.1
symbol: blos-9
gene_biotype: protein_coding
description:
  BLOC-1-related complex subunit 8 homolog; May participate in the coupling of lysosomes to microtubule plus-end-directed kinesin motor; Belongs to the BORCS8 family.


ensembl_gene_id: K11C4.4.1
symbol: odc-1
gene_biotype: protein_coding
description:
  Ornithine decarboxylase; Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.


ensembl_gene_id: K11D12.10c.1
symbol: mlk-1
gene_biotype: protein_coding
description:
  Mitogen-activated protein kinase kinase kinase mlk-1; Serine/threonine-protein kinase which, by phosphorylating and activating mek-1, plays an important role in the activation of the JNK pathway composed of mlk-1, mek-1 and kgb-1. Involved in the response to environmental stress such as heavy metals. By activating the JNK pathway downstream of tyrosine receptor svh-2, plays a role in axon regeneration after injury.


ensembl_gene_id: K11D2.2.1
symbol: asah-1
gene_biotype: protein_coding
description:
  Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH.


ensembl_gene_id: K11D2.3a.2
symbol: unc-101
gene_biotype: protein_coding
description:
  AP-1 complex subunit mu-1-I; Component of the adaptor complexes which link clathrin to receptors in coated vesicles (Probable). Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration (Probable). Required for many aspects of development and behavior, including negative regulation of vulval differentiation. Required for the dendritic localization of potassium channel kvs-4 in the cholinergic motor neuron DA9.


ensembl_gene_id: K11D9.2a.1
symbol: sca-1
gene_biotype: protein_coding
description:
  Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.


ensembl_gene_id: K11E8.1r.1
symbol: unc-43
gene_biotype: protein_coding
description:
  Calcium/calmodulin-dependent protein kinase type II; Acts in the signaling of a variety of pathways and processes. Phosphorylates 'Ser-319' of daf-16 in response to stress signals, such as heat, starvation and oxidation, which plays a role in prolonging lifespan. Required for viability under chronic osmotic stress in which it acts downstream of osr-1. Has roles in locomotion, oocyte maturation, brood size, egg laying, defecation, meiotic maturation and neuronal cell fate specification. Required for the regulation of synaptic density and neuromuscular junction morphology. Regulates the  [...]


ensembl_gene_id: K11G12.2.1
symbol: acr-2
gene_biotype: protein_coding
description:
  Acetylcholine receptor subunit beta-type acr-2; Non-alpha subunit of nicotinic acetylcholine receptor (nAChR). Acts in cholinergic motoneurons to regulate presynaptic neurotransmitter release, thereby ensuring normal level of excitation of cholinergic motoneurons during locomotion. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.


ensembl_gene_id: K11G12.3.1
symbol: smf-2
gene_biotype: protein_coding
description:
  NRAMP-like transporter smf-2; Probable divalent metal ion transporter which regulates Mn(2+) uptake.


ensembl_gene_id: K11G12.4a.1
symbol: smf-1
gene_biotype: protein_coding
description:
  NRAMP-like transporter smf-1; Probable divalent metal ion transporter which regulates Mn(2+) uptake; Belongs to the NRAMP family.


ensembl_gene_id: K11G12.6b.1
symbol: K11G12.6
gene_biotype: protein_coding
description:
  Lipase maturation factor; Involved in the maturation of specific proteins in the endoplasmic reticulum; Belongs to the lipase maturation factor family.


ensembl_gene_id: K11G12.7.1
symbol: acr-3
gene_biotype: protein_coding
description:
  Acetylcholine receptor subunit beta-type acr-3; Non-alpha subunit of nicotinic acetylcholine receptor (nAChR). Probably acts in cholinergic motoneurons to regulate presynaptic neurotransmitter release, thereby ensuring normal level of excitation of cholinergic motoneurons during locomotion.


ensembl_gene_id: K11H3.3.1
symbol: K11H3.3
gene_biotype: protein_coding
description:
  Putative tricarboxylate transport protein, mitochondrial; Transport of citrate across inner mitochondrial membrane. Belongs to the mitochondrial carrier (TC 2.A.29) family.


ensembl_gene_id: K12C11.2.1
symbol: smo-1
gene_biotype: protein_coding
description:
  Small ubiquitin-related modifier; Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex aos-1-uba-2 and linkage to the E2 enzyme ubc-9, and can be promoted by an E3 ligase such as gei-17. Required for embryonic dev [...]


ensembl_gene_id: K12C11.4a.1
symbol: dapk-1
gene_biotype: protein_coding
description:
  Death-associated protein kinase dapk-1; Negative regulator of epidermal barrier repair and innate immune responses to wounding. The role in epidermal tissue integrity and wound healing is established through the inhibition of epidermal microtubule stability, possibly via the negative regulation of the microtubule minus-end binding protein ptrn-1. In epidermis, prevents expression of specific unc-44 isoforms probably by promoting nuclear localization of pinn-1, which in turn may affect sydn-1-ssup-72-mediated regulation of alternative polyadenylation of unc-44 mRNA. Appears to act downs [...]


ensembl_gene_id: K12D12.1.1
symbol: top-2
gene_biotype: protein_coding
description:
  DNA topoisomerase 2 top-2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks (By similarity). Essential during mitosis in the adult germline and during embryogenesis for proper segregation of daughter chromosomes. Required for centromere resolution during mitosis. Required for chromosome segregation in anaphase of meiosis I during spermatogenesis. Promotes cleavage furrow stability during cytokinesis upon the presence of chromatin obstructions. Promotes DNA break formation upon zygotic genome [...]


ensembl_gene_id: K12F2.1.1
symbol: myo-3
gene_biotype: protein_coding
description:
  Myosin-3; Essential for muscle contraction. Involved in ovulation likely by regulating the contraction of gonadal myoepithelial sheath cells. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.


ensembl_gene_id: K12F2.2a.1
symbol: vab-8
gene_biotype: protein_coding
description:
  Kinesin-like protein vab-8; Required for posterior migration of cells and axon growth cones during nervous system assembly. [Isoform b]: Specifically required for CAN cell migration.


ensembl_gene_id: K12H4.1.1
symbol: pros-1
gene_biotype: protein_coding
description:
  Homeobox protein prospero homolog 1; Transcription factor involved in developmental processes (By similarity). Controls the transcription of genes required for excretory canal formation.


ensembl_gene_id: K12H4.3.1
symbol: K12H4.3
gene_biotype: protein_coding
description:
  Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. Belongs to the BRX1 family.


ensembl_gene_id: K12H4.4.1
symbol: K12H4.4
gene_biotype: protein_coding
description:
  Probable signal peptidase complex subunit 3; Component of the microsomal signal peptidase complex which removes signal peptides and other N-terminal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.


ensembl_gene_id: K12H4.8.2
symbol: dcr-1
gene_biotype: protein_coding
description:
  Death-promoting deoxyribonuclease; Involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. It produces 21 to 23 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs. Seems to process the precursor of the small temporal RNA let-7 which is involved in developmental timing. Belongs to the helicase family. Dicer subfamily.


ensembl_gene_id: LLC1.1a.1
symbol: tra-3
gene_biotype: protein_coding
description:
  Calpain-5; Required for the correct female sexual development of the soma and germline in hermaphrodite animals, while being fully dispensable in males. Has calcium-dependent proteolytic activity and is involved in the cleavage of tra-2, for which it acts as a potentiator. Capable of calcium-dependent autolysis. Part of the necrosis cell death pathway. Required for necrosis of intestinal cells induced by B.thuringiensis endotoxin Cry6Aa ; Belongs to the peptidase C2 family.


ensembl_gene_id: M01A10.3.2
symbol: ostd-1
gene_biotype: protein_coding
description:
  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...]


ensembl_gene_id: M01B12.3.1
symbol: arx-7
gene_biotype: protein_coding
description:
  Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.


ensembl_gene_id: M01B12.5a.2
symbol: riok-1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase RIO1; Involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit (By similarity). Despite the protein kinase domain is proposed to act predominantly as an ATPase (By similarity). The catalytic activity regulates its dynamic association with the 40S subunit (By similarity). Plays a role in oogenesis by regulating germ cell proliferation, progression through diplotene and diakinesis stages and oocyte maturation. Regulates germline development probably by regulating the phosphorylation of mpk- 1. Involved in larval development. ECO:0 [...]


ensembl_gene_id: M01D7.6.1
symbol: emr-1
gene_biotype: protein_coding
description:
  Emerin homolog 1; Involved in chromosome segregation and cell division, probably via its interaction with lmn-1, the main component of nuclear lamina. Has some overlapping function with lem-2. May play a role in radiation- induced DNA damage repair response.


ensembl_gene_id: M01E11.7a.1
symbol: tns-1
gene_biotype: protein_coding
description:
  Tensin homolog; Probable phosphatase which regulates axon regeneration after injury by linking the svh-2 and integrin signaling pathways.


ensembl_gene_id: M01E5.5a.2
symbol: top-1
gene_biotype: protein_coding
description:
  DNA topoisomerase 1; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)- enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus remo [...]


ensembl_gene_id: M01E5.6.1
symbol: sepa-1
gene_biotype: protein_coding
description:
  Protein sepa-1; Adapter protein that connects P-granules in somatic cells with the autophagic machinery. Association with other adapters such as epg-2 and P-granule components such as pgl-3 is required for the accumulation and degradation of P-granules by autophagy in somatic cells. This ensures exclusive localization of the P-granules in germ cells.


ensembl_gene_id: M01F1.3.3
symbol: M01F1.3
gene_biotype: protein_coding
description:
  Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives; Belongs to the radical SAM superfamily. Lipoyl synthase family.


ensembl_gene_id: M01G5.5.1
symbol: snf-6
gene_biotype: protein_coding
description:
  Sodium-dependent acetylcholine transporter; Mediates sodium-dependent uptake of acetylcholine at neuromuscular junctions during periods of increased synaptic activity, may also prevent spillover to adjacent synaptic sites. Not involved in the uptake of other neurotransmitters (GABA, glycine, proline and glutamate) and there was also no inhibition of uptake by adding an excess of other candidate substrates (GABA, glycine, taurine, creatine, proline, alanine, carnitine, glutamate and betaine). Required for muscle integrity; altered transport of acetylcholine due to loss of dystrophin-gly [...]


ensembl_gene_id: M02B1.1a.1
symbol: srf-3
gene_biotype: protein_coding
description:
  UDP-galactose/UDP-N-acetylglucosamine transporter srf-3; Acts as a transporter of both UDP-galactose and UDP-N- acetylglucosamine into the Golgi lumen.


ensembl_gene_id: M02B7.3b.1
symbol: osm-3
gene_biotype: protein_coding
description:
  Osmotic avoidance abnormal protein 3; Kinesin motor protein which is required for the anterograde intraflagellar transport (IFT) along the middle segment of the sensory neuron cilia together with the kinesin II motor complex (composed of klp-11, klp-20 and kap-1) and on its own, is required for IFT along the distal segment. In addition, regulates the length of cilia. May have a role during neurogenesis and axonal transport.


ensembl_gene_id: M02H5.6a.1
symbol: nhr-98
gene_biotype: protein_coding
description:
  Nuclear hormone receptor family member nhr-98; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family.


ensembl_gene_id: M03A1.1b.1
symbol: vab-1
gene_biotype: protein_coding
description:
  Ephrin receptor 1; Receptor for members of the ephrin family (By similarity). Receptor for major sperm proteins (MSPs), that functions as sperm- sensing checkpoint which inhibits oocyte meiotic maturation and ovulation when sperm are not available for fertilization. Specifically, functions to negatively regulates oocyte maturation and MAPK activation in the absence of MSPs. Required for the MSP-mediated increase in the basal sheath cell contraction rate in somatic cells. Phosphorylates phosphatase daf-18/PTEN which probably promotes daf-18 degradation. By inactivating daf-18, regulates [...]


ensembl_gene_id: M03A8.2.2
symbol: atg-2
gene_biotype: protein_coding
description:
  Autophagy-related protein 2; Component of the epg-6/atg-2 complex, which is involved in the generation of autophagosomes from omegasomes and in the distribution of atg-9 and atg-13 during the autophagy-mediated degradation of protein aggregates. Involved in autophagy-mediated degradation of ribosomal RNA and ribosomal proteins in lysosomes, which is essential for maintaining nucleotide homeostasis.


ensembl_gene_id: M03C11.2.1
symbol: chl-1
gene_biotype: protein_coding
description:
  ATP-dependent DNA helicase chl-1; Required for normal cell proliferation and chromosome stability. Plays a role in DNA repair during replication. Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.


ensembl_gene_id: M03C11.5.2
symbol: ymel-1
gene_biotype: protein_coding
description:
  ATP-dependent zinc metalloprotease YME1 homolog; ATP-dependent metalloprotease that catalyzes the degradation of folded and unfolded proteins with a suitable degron sequence in the mitochondrial intermembrane region (By similarity). Plays an important role in regulating mitochondrial morphology and function (By similarity); In the C-terminal section; belongs to the peptidase M41 family.


ensembl_gene_id: M03C11.8.1
symbol: M03C11.8
gene_biotype: protein_coding
description:
  DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double- strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs (By similarity).


ensembl_gene_id: M03E7.5.3
symbol: memb-2
gene_biotype: protein_coding
description:
  Golgi SNAP receptor complex member 2; Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.


ensembl_gene_id: M03F4.2a.1
symbol: act-4
gene_biotype: protein_coding
description:
  Actin-4; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.


ensembl_gene_id: M03F8.2b.1
symbol: pst-1
gene_biotype: protein_coding
description:
  Adenosine 3'-phospho 5'-phosphosulfate transporter 1; Mediates the transport of adenosine 3'-phospho 5'- phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi (By similarity).


ensembl_gene_id: M03F8.4.1
symbol: galt-1
gene_biotype: protein_coding
description:
  Beta-1,4-galactosyltransferase galt-1; Catalyzes the transfer of beta-galactose from UDP-galactose to position 4 of alpha-1,6-linked fucose at the reducing end GlcNAc in N-glycan cores. Involved in susceptibility to the nematotoxic C.cinerea galectin Cgl2, likely by contributing to the synthesis of core alpha-1,6-fucosylated N-glycans to which Cgl2 binds.


ensembl_gene_id: M04B2.1.1
symbol: mep-1
gene_biotype: protein_coding
description:
  MOG interacting and ectopic P-granules protein 1; Has a broad role in development, specifically in the genetic pathway SynMuvB that negatively regulates specification of the vulval cell fate. Required for fem-3 3'-UTR-mediated repression in the regulation of the sperm/oocyte switch. Acts by regulating the translation of fem-3 mRNA, by binding to its 3'-UTR.


ensembl_gene_id: M04C7.1.1
symbol: gpa-15
gene_biotype: protein_coding
description:
  Guanine nucleotide-binding protein alpha-15 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems; Belongs to the G-alpha family.


ensembl_gene_id: M04C9.5b.1
symbol: dyf-5
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase dyf-5; Serine/threonine-protein kinase which is required for ciliogenesis. Regulates the length and the morphology of sensory neuron cilia. In addition, plays a role in the anterograde intraflagellar transport (IFT) in the cilia by regulating the undocking of kinesin-II motor complex (composed of klp-11, klp-20 and kap-1) before reaching the distal segment and the docking of kinesin motor osm-3 onto IFT cargos; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. RCK subfamily.


ensembl_gene_id: M04G12.3.1
symbol: gcy-34
gene_biotype: protein_coding
description:
  Soluble guanylate cyclase gcy-34; Synthesizes cyclic GMP (cGMP) from GTP (By similarity). May be involved in sensitivity to quinine by regulating egl-4 activity through the production of cGMP. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.


ensembl_gene_id: M106.1.1
symbol: mix-1
gene_biotype: protein_coding
description:
  Mitotic chromosome and X-chromosome-associated protein mix-1; Essential protein required for both chromosome condensation and segregation and X-chromosome dosage compensation depending on its binding partners. Central component of the condensin I complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases. Converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (By similarity). Central component o [...]


ensembl_gene_id: M106.5.1
symbol: cap-2
gene_biotype: protein_coding
description:
  F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.


ensembl_gene_id: M142.1c.1
symbol: unc-119
gene_biotype: protein_coding
description:
  Protein unc-119; Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Plays a key role in ciliary membrane localization of proteins. Required for the establishment or function of the nervous system.


ensembl_gene_id: M142.4.1
symbol: vab-7
gene_biotype: protein_coding
description:
  Homeobox protein vab-7; Required for posterior-specific pattern formation in the embryo and may have a role in regulating egl-5 expression.


ensembl_gene_id: M142.6a.1
symbol: rle-1
gene_biotype: protein_coding
description:
  Regulation of longevity by E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase. Regulates the activity of daf-16 and is thereby involved in regulating aging and stress resistance. Regulates nsy-1 activity and thereby attenuates the activation of sek-1 and pmk-1, two components of the p38 pathway, which results in susceptibility to pathogenic bacterial infection.


ensembl_gene_id: M142.8a.1
symbol: M142.8
gene_biotype: protein_coding
description:
  Protein-lysine N-methyltransferase M142.8; S-adenosyl-L-methionine-dependent protein-lysine N- methyltransferase that methylates elongation factor 1-alpha. Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.


ensembl_gene_id: M163.3.1
symbol: his-24
gene_biotype: protein_coding
description:
  Histone 24; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.


ensembl_gene_id: M163.4.1
symbol: gfi-3
gene_biotype: protein_coding
description:
  Protein gfi-3; Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins. Required for the metaphase to anaphase transition in meiosis.


ensembl_gene_id: M176.3.1
symbol: chch-3
gene_biotype: protein_coding
description:
  MICOS complex subunit MIC19; Plays a role in maintaining mitochondrial morphology. May act as a component of the MICOS complex, a large protein complex of the mitochondria (By similarity). Belongs to the MICOS complex subunit Mic19 family. Metazoan Mic19 subfamily.


ensembl_gene_id: M176.6a.1
symbol: kin-15
gene_biotype: protein_coding
description:
  Receptor-like tyrosine-protein kinase kin-15; May be specifically involved in cell-cell interactions regulating cell fusions that generate the hypodermis during postembryonic development. It has a role in the development of the HYP7 hypodermal syncytium.


ensembl_gene_id: M176.7.1
symbol: kin-16
gene_biotype: protein_coding
description:
  Receptor-like tyrosine-protein kinase kin-16; May be specifically involved in cell-cell interactions regulating cell fusions that generate the hypodermis during postembryonic development. It has a role in the development of the HYP7 hypodermal syncytium.


ensembl_gene_id: M18.2.1
symbol: dlc-2
gene_biotype: protein_coding
description:
  Probable dynein light chain 2, cytoplasmic; Acts as one of several non-catalytic accessory components of a dynein complex; Belongs to the dynein light chain family.


ensembl_gene_id: M18.5.1
symbol: ddb-1
gene_biotype: protein_coding
description:
  DNA damage-binding protein 1; Plays a role in DNA repair. May be a component of an E3 ubiquitin-protein ligase which promotes histone ubiquitination in response to UV irradiation. Histone ubiquitination may be important for subsequent DNA repair (By similarity). Promotes the degradation of the replication licensing factor cdt-1 during S-phase, thereby preventing rereplication of DNA during a single round of cell division.


ensembl_gene_id: M195.3.1
symbol: amt-3
gene_biotype: protein_coding
description:
  Putative ammonium transporter 3; Involved in the uptake of ammonia; Belongs to the ammonia transporter channel (TC 1.A.11.2) family.


ensembl_gene_id: M28.5.1
symbol: M28.5
gene_biotype: protein_coding
description:
  NHP2-like protein 1 homolog; Binds to the 5'-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding (By similarity); Belongs to the eukaryotic ribosomal protein eL8 family.


ensembl_gene_id: M6.1b.1
symbol: ifc-2
gene_biotype: protein_coding
description:
  Intermediate filament protein ifc-2; Cytoplasmic intermediate filaments provide mechanical strength to cells. Not essential protein, although its absence leads to mild defects in locomotion.


ensembl_gene_id: M7.1.1
symbol: let-70
gene_biotype: protein_coding
description:
  Ubiquitin-conjugating enzyme E2 2; Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity). Mediates the selective degradation of short- lived and abnormal proteins. Plays a role in the DNA damage response. In particular, in response to ionizing radiation, associates with the E3 ubiquitin-protein ligase brc-1-brd-1 heterodimer on chromatin to activate E3-ubiquitin ligase activity of the heterodimer, and thus its DNA damage repair mechanisms ; Belongs to the ubiquitin-conjugating enzyme family.


ensembl_gene_id: M7.5.1
symbol: atg-7
gene_biotype: protein_coding
description:
  Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for autophagy.


ensembl_gene_id: M79.1a.1
symbol: abl-1
gene_biotype: protein_coding
description:
  Tyrosine-protein kinase abl-1; Functions downstream of migratory protein mig-13 and is involved in Q neuroblast migration during larval development. Recruited by mig-13 to the leading edge of Q neuroblasts and their descendents to signal downstream, likely to the wve-1 pathway, and direct migration along the anteroposterior body axis. Promotes germline cell apoptosis in response to oxidative, osmotic and heat shock stresses. Belongs to the protein kinase superfamily. Tyr protein kinase family. ABL subfamily.


ensembl_gene_id: M79.4.1
symbol: flp-19
gene_biotype: protein_coding
description:
  FMRFamide-like neuropeptides 19; FMRFamides and FMRFamide-like peptides are neuropeptides. WANQVRF-amide inhibits the activity of dissected pharyngeal myogenic muscle system; Belongs to the FARP (FMRFamide related peptide) family.


ensembl_gene_id: M88.6b.1
symbol: pan-1
gene_biotype: protein_coding
description:
  P-granule-associated novel protein 1; Regulates diverse developmental processes including larval molting and gonad maturation.


ensembl_gene_id: MTCE.11.1
symbol: nduo-1
gene_biotype: protein_coding
description:
  NADH-ubiquinone oxidoreductase chain 1; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.


ensembl_gene_id: MTCE.12.1
symbol: atp-6
gene_biotype: protein_coding
description:
  ATP synthase subunit a; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subuni [...]


ensembl_gene_id: MTCE.16.1
symbol: nduo-2
gene_biotype: protein_coding
description:
  NADH-ubiquinone oxidoreductase chain 2; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).


ensembl_gene_id: MTCE.21.1
symbol: ctb-1
gene_biotype: protein_coding
description:
  Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c (By similarity). Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.


ensembl_gene_id: MTCE.23.1
symbol: ctc-3
gene_biotype: protein_coding
description:
  Cytochrome c oxidase subunit 3; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...]


ensembl_gene_id: MTCE.25.1
symbol: nduo-4
gene_biotype: protein_coding
description:
  NADH-ubiquinone oxidoreductase chain 4; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.


ensembl_gene_id: MTCE.26.1
symbol: ctc-1
gene_biotype: protein_coding
description:
  Cytochrome c oxidase subunit 1; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...]


ensembl_gene_id: MTCE.3.1
symbol: nduo-6
gene_biotype: protein_coding
description:
  NADH-ubiquinone oxidoreductase chain 6; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).


ensembl_gene_id: MTCE.31.1
symbol: ctc-2
gene_biotype: protein_coding
description:
  Cytochrome c oxidase subunit 2; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...]


ensembl_gene_id: MTCE.34.1
symbol: nduo-3
gene_biotype: protein_coding
description:
  NADH-ubiquinone oxidoreductase chain 3; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).


ensembl_gene_id: MTCE.35.1
symbol: nduo-5
gene_biotype: protein_coding
description:
  NADH-ubiquinone oxidoreductase chain 5; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).


ensembl_gene_id: MTCE.4.1
symbol: ndfl-4
gene_biotype: protein_coding
description:
  NADH-ubiquinone oxidoreductase chain 4L; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).


ensembl_gene_id: PAR2.1.1
symbol: mtss-1
gene_biotype: protein_coding
description:
  Single-stranded DNA-binding protein, mitochondrial; Has a role in germline cell development and proliferation which affects the frequency of apoptosis. Required for mitochondrial DNA replication and transcription and fertility.


ensembl_gene_id: PAR2.3a.2
symbol: aak-1
gene_biotype: protein_coding
description:
  5'-AMP-activated protein kinase catalytic subunit alpha-1; Probably does not act as a sensor that couples lifespan to information about energy levels and insulin-like signals. Together with aak-2, involved in the establishment of germline stem cell (GSC) quiescence during dauer development. Plays a role in the maintenance of glycogen stores which are necessary for resistance to hyperosmotic stress.


ensembl_gene_id: PAR2.4a.3
symbol: mig-22
gene_biotype: protein_coding
description:
  Chondroitin sulfate synthase mig-22; Has both beta-1,3-glucuronic acid and beta-1,4-N- acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP- GalNAc to the non-reducing end of the elongating chondroitin polymer (By similarity). Required together with sqv-5 for the biosynthesis of chondroitin. Chondroitin is involved in organogenesis of the vulva, maturation of the gonad, and neural development. May have a specific role in unc- 6/netrin-mediated dorsal guidance of gonadal distal tip cells. Glycosyltransfera [...]


ensembl_gene_id: R01B10.1a.1
symbol: cpi-2
gene_biotype: protein_coding
description:
  Cystatin cpi-2; Cysteine protease inhibitor which inhibits members of the peptidase C1 family. Does not inhibit asparaginyl endopeptidase. Required for the uptake and/or processing of yolk proteins during the development of oocytes, probably by regulating the catalytic activity of cysteine proteases cpl-1 and cpz-1. May play a protective role against exogenous cysteine proteases derived from soil bacteria or fungi, or rotting fruits and vegetation. Belongs to the cystatin family.


ensembl_gene_id: R01B10.4.1
symbol: R01B10.4
gene_biotype: protein_coding
description:
  Post-GPI attachment to proteins factor 3; Involved in the lipid remodeling steps of GPI-anchor maturation; Belongs to the PGAP3 family.


ensembl_gene_id: R01E6.1b.1
symbol: odr-1
gene_biotype: protein_coding
description:
  Receptor-type guanylate cyclase gcy-10; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Regulates chemotaxis responses toward volatile odorants in AWC sensory neurons and their avoidance in AWB sensory neurons. May be involved in sensitivity to quinine by regulating egl-4 activity through the production of cGMP. Involved in phototransduction in ASJ neurons downstream of G protein coupled-photoreceptor lite-1. Required to maintain the expression of putative olfactory receptor str-2 in AWC neurons in adults. In AWB and AWC sensory neurons, media [...]


ensembl_gene_id: R01H10.1.1
symbol: div-1
gene_biotype: protein_coding
description:
  DNA polymerase alpha subunit B; May play an essential role at the early stage of chromosomal DNA replication by coupling the polymerase alpha/primase complex to the cellular replication machinery. Required for the distribution of pie-1 in cell divsion.


ensembl_gene_id: R01H10.3c.2
symbol: cor-1
gene_biotype: protein_coding
description:
  Coronin-like protein cor-1; Required to direct the migration of Q neuroblasts along the anterior axis of the body during larval development. This is dependent on its asymmetric expression in Q neuroblasts. Belongs to the WD repeat coronin family.


ensembl_gene_id: R01H10.6.1
symbol: bbs-5
gene_biotype: protein_coding
description:
  Bardet-Biedl syndrome 5 protein homolog; Component of the BBSome complex (By similarity). The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia (By similarity). The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function (By similarity). Required for BBSome complex ciliary localization but not for the proper complex assembly (By similarity). Required, redundantly with bbs-4, for cilia biogenesis and both the assembly and movement of intraflagellar transport proteins al [...]


ensembl_gene_id: R01H10.8.1
symbol: cnk-1
gene_biotype: protein_coding
description:
  Connector enhancer of kinase suppressor of ras; Non-essential component of the Ras signaling pathway.


ensembl_gene_id: R01H2.3.2
symbol: egg-2
gene_biotype: protein_coding
description:
  LDL receptor repeat-containing protein egg-2; Probable receptor which is required for the oocyte-to-zygote transition although its exact function is controversial. Redundantly with egg-1, seems to be required for fertilization probably by promoting the interaction or fusion between sperm and oocyte. Conversely, shown to be dispensable for fertilization but required together with egg-1 for the formation of a continuous and cohesive eggshell chitin layer by maintaining a homogenous distribution of chitin synthase chs-1 at the unfertilized oocyte cell membrane. Appears to recruit or maint [...]


ensembl_gene_id: R01H2.5.1
symbol: ger-1
gene_biotype: protein_coding
description:
  GDP-L-fucose synthase; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction; Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.


ensembl_gene_id: R02D1.1a.1
symbol: nhr-125
gene_biotype: protein_coding
description:
  Nuclear hormone receptor family member nhr-125; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family.


ensembl_gene_id: R02E12.6.2
symbol: hrg-1
gene_biotype: protein_coding
description:
  Heme transporter hrg-1; Heme transporter that regulates intracellular heme availability through the endosomal or lysosomal compartment. Belongs to the HRG family.


ensembl_gene_id: R02F2.2.1
symbol: osg-1
gene_biotype: protein_coding
description:
  Rho guanine nucleotide exchange factor osg-1; Probable guanine nucleotide exchange factor which regulates the Rho GTPase rho-1. Functions in ASE sensory neurons where it promotes neuronal degeneration under conditions of oxidative stress.


ensembl_gene_id: R03A10.3.1
symbol: mocs-1
gene_biotype: protein_coding
description:
  Molybdenum cofactor sulfurase; Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.


ensembl_gene_id: R03D7.1.1
symbol: metr-1
gene_biotype: protein_coding
description:
  Probable methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity).


ensembl_gene_id: R03D7.4.1
symbol: tceb-3
gene_biotype: protein_coding
description:
  Transcription elongation factor B polypeptide 3; SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).


ensembl_gene_id: R03D7.5a.1
symbol: R03D7.5
gene_biotype: protein_coding
description:
  Putative serine/threonine-protein kinase R03D7.5; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.


ensembl_gene_id: R03D7.6a.1
symbol: gst-5
gene_biotype: protein_coding
description:
  Probable glutathione S-transferase 5; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (By similarity). May play a role in the detoxification of reactive oxygen species produced during pathogenic bacterial infection. Belongs to the GST superfamily. Sigma family.


ensembl_gene_id: R03E9.4.1
symbol: irk-1
gene_biotype: protein_coding
description:
  Inward rectifier potassium channel irk-1; Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Required for modulation of the activity of the hermaphrodite-specific neurons (HSNs) by the G-protein coupled neuropeptide receptor egl-6 which in turn controls egg-laying behavior.


ensembl_gene_id: R03G5.2.1
symbol: sek-1
gene_biotype: protein_coding
description:
  Dual specificity mitogen-activated protein kinase kinase sek-1; Dual specificity protein kinase which acts as an essential component of the p38 signal transduction pathway which is also composed of upstream effector nsy-1 and downstream effector pmk-1. May phosphorylate pmk-1. Downstream of CaMKII unc-43 and adapter protein tir- 1, plays a role in determining asymmetric cell fates in olfactory AWC neurons during neuronal development. Activation results in the repression of odorant receptor str-2 expression in one of the 2 AWC neurons. Involved in resistance to pathogenic Gram-positive  [...]


ensembl_gene_id: R04A9.2.1
symbol: nrde-3
gene_biotype: protein_coding
description:
  Nuclear RNAi defective-3 protein; Transports small interfering RNAs (siRNAs) from the cytoplasm to the nucleus. Required for RNA interference (RNAi) in nuclei. Required for exogenous RNAi-induced H3K27 methylation.


ensembl_gene_id: R04A9.4.1
symbol: ife-2
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 4E-2; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. All 5 eIF4E proteins bind monomethyl cap structures. Only ife-1, ife-2 and ife-5 bind trimethyl cap structures which result from trans-splicing. Translation of trimethyl cap structure mRNAs may be regulated by intracellular redox state; disulfide bonds change the width and depth of the cap-binding cavity determining selectivit [...]


ensembl_gene_id: R04B3.2.1
symbol: R04B3.2
gene_biotype: protein_coding
description:
  Putative N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase; Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins.


ensembl_gene_id: R04B5.4b.1
symbol: nhr-12
gene_biotype: protein_coding
description:
  Nuclear hormone receptor family member nhr-12; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family.


ensembl_gene_id: R04E5.10a.1
symbol: ifd-1
gene_biotype: protein_coding
description:
  Intermediate filament protein ifd-1; Cytoplasmic intermediate filaments provide mechanical strength to cells. Not essential protein.


ensembl_gene_id: R04E5.2.1
symbol: cnnm-2
gene_biotype: protein_coding
description:
  Metal transporter cnnm-2; Probable metal transporter. Probably acts redundantly with the other metal transport proteins cnnm-1, cnnm-3, cnnm-4 and cnnm-5 to regulate Mg(2+) homeostasis.


ensembl_gene_id: R05D11.3.1
symbol: ran-4
gene_biotype: protein_coding
description:
  Probable nuclear transport factor 2; Facilitates protein transport into the nucleus. Could be part of a multicomponent system of cytosolic factors that assemble at the pore complex during nuclear import (By similarity).


ensembl_gene_id: R05D11.6.1
symbol: paxt-1
gene_biotype: protein_coding
description:
  Partner of xrn-2 protein 1; Plays a role in maintenance of steady-state concentration and turnover of microRNAs (miRNA) by degradation of mature miRNA in complex with the exoribonuclease xrn-2. Stabilizes and enhances the accumulation and activity of the exoribonuclease xrn-2, and thus contributes to miRNA turnover.


ensembl_gene_id: R05D3.11.1
symbol: met-2
gene_biotype: protein_coding
description:
  Histone-lysine N-methyltransferase met-2; Histone methyltransferase which is required for the mono- and dimethylation of 'Lys-9' of histone H3. This increases the efficiency of set-25-mediated trimethylation of histone H3 'Lys-9'. Involved in the transcriptional repression of lin-3 which is required for the negative regulation of vulval cell fate specification during postembryonic development. Has a role in blocking checkpoint signaling and mediating the transcriptional silencing of meiotic sex chromosome inactivation; a mechanism which enables checkpoint proteins to distinguish betwee [...]


ensembl_gene_id: R05D3.12a.1
symbol: R05D3.12
gene_biotype: protein_coding
description:
  Putative DNA topoisomerase 2, mitochondrial; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks (By similarity); Belongs to the type II topoisomerase family.


ensembl_gene_id: R05D3.4b.1
symbol: rfp-1
gene_biotype: protein_coding
description:
  E3 ubiquitin-protein ligase bre-1; E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-117' of histone H2B. H2B 'Lys-117' ubiquitination gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. Belongs to the BRE1 family.


ensembl_gene_id: R05D3.6.1
symbol: R05D3.6
gene_biotype: protein_coding
description:
  Putative ATP synthase subunit epsilon, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechan [...]


ensembl_gene_id: R05D3.7.1
symbol: unc-116
gene_biotype: protein_coding
description:
  Kinesin heavy chain; Microtubule-dependent motor protein required for organelle transport. Plays a role in endosome transport. Required for the transport of mitochondria along the axon of motor neurons. Involved in the nuclear migration of hyp7 hypodermal precursor cells. Required for the formation of dendritic branches of PVD sensory neurons. In non-ciliated neurons such as the PVD and PHC neurons, required for the organization of minus-end out microtubules in dendrites. Involved in the localization of unc-33 to neurites.


ensembl_gene_id: R05F9.3.1
symbol: msp-32
gene_biotype: protein_coding
description:
  Major sperm protein 32; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.


ensembl_gene_id: R05F9.5.1
symbol: gst-9
gene_biotype: protein_coding
description:
  Probable glutathione S-transferase 9; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Belongs to the GST superfamily. Sigma family.


ensembl_gene_id: R05F9.8.1
symbol: msp-33
gene_biotype: protein_coding
description:
  Major sperm protein 33; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.


ensembl_gene_id: R05G6.4.1
symbol: R05G6.4
gene_biotype: protein_coding
description:
  Nitric oxide synthase-interacting protein homolog; Negatively regulates nitric oxide production by inducing nitric oxide synthase translocation to actin cytoskeleton and inhibiting its enzymatic activity; Belongs to the NOSIP family.


ensembl_gene_id: R05G6.7.1
symbol: vdac-1
gene_biotype: protein_coding
description:
  Probable voltage-dependent anion-selective channel; Forms a channel through the cell membrane that allows diffusion of small hydrophilic molecules.


ensembl_gene_id: R05H10.5b.1
symbol: gpx-2
gene_biotype: protein_coding
description:
  Glutathione peroxidase 2; May constitute a glutathione peroxidase-like protective system against oxidative stresses.


ensembl_gene_id: R05H5.1.1
symbol: srd-2
gene_biotype: protein_coding
description:
  Serpentine receptor class delta-2; Thought to be a chemosensory receptor. Belongs to the nematode receptor-like protein srd family.


ensembl_gene_id: R05H5.6.1
symbol: srb-6
gene_biotype: protein_coding
description:
  Serpentine receptor class beta-6; Mediates recognition and avoidance of Streptomyces species by detecting dodecanoic acid secreted by the bacteria. Also mediates avoidance of decanoic acid which is not secreted by Streptomyces species but this may represent an additional important avoidance response in the environment; Belongs to the nematode receptor-like protein srb family.


ensembl_gene_id: R06A4.7.1
symbol: mes-2
gene_biotype: protein_coding
description:
  Histone-lysine N-methyltransferase mes-2; Polycomb group (PcG) protein. Catalytic subunit of a the mes- 2/mes-3/mes-6 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target genes. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. The mes-2/mes-3/mes-6 complex may participate in the global inactivation of the X c [...]


ensembl_gene_id: R06A4.9a.1
symbol: pfs-2
gene_biotype: protein_coding
description:
  pre-mRNA 3' end processing protein pfs-2; Essential for both cleavage and polyadenylation of pre-mRNA 3' ends (By similarity). Involved in neuron development, probably by regulating pre-mRNA 3'-end processing.


ensembl_gene_id: R06B10.4b.1
symbol: trp-2
gene_biotype: protein_coding
description:
  TRP (Transient receptor potential) channel family; Belongs to the transient receptor (TC 1.A.4) family.


ensembl_gene_id: R06B9.6.1
symbol: mig-14
gene_biotype: protein_coding
description:
  Protein wntless homolog; Probable sorting receptor which regulates endocytosis and secretion of the wnt ligand egl-20. Recycling of mig-14 from the plasma membrane to the Golgi apparatus by the retromer complex is essential for its function. Its endosomal trafficking is regulated by its association with sorting nexin snx-3 on early endosomes and the mtm-6/mtm-9 myotubularin complex. Required in embryonic development for endoderm specification and the correct positioning and orientation of the mitotic spindles and division planes in blastomere cells. Functions during vulval development, [...]


ensembl_gene_id: R06C7.1.1
symbol: wago-1
gene_biotype: protein_coding
description:
  Argonaute protein wago-1; Argonaute protein which is involved in the endogenous small interfering RNA (endo-siRNA) pathway. Interacts with secondary 22G- RNAs, which are RNA-dependent RNA polymerase-derived endo-siRNAs, typically 22 nucleotides in length with a 5'guanosine residue. In the germline, functions in a genome surveillance system to silence transposons and aberrant transcripts.


ensembl_gene_id: R06C7.5a.2
symbol: adsl-1
gene_biotype: protein_coding
description:
  Adenylosuccinate lyase; Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate.


ensembl_gene_id: R06C7.6.1
symbol: R06C7.6
gene_biotype: protein_coding
description:
  Protein N-terminal glutamine amidohydrolase; Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position.


ensembl_gene_id: R06C7.7b.1
symbol: lin-61
gene_biotype: protein_coding
description:
  Protein lin-61; Synthetic multivulva class B (synMuvB) protein required to repress the induction of vulval development by Ras signaling. Unlike other synMuv proteins it does not associate with the multiprotein DRM complex and the NuRD-like complex. Interaction with methylated histone H3 is essential for vulva development. It has a role in maintaining genome stability.


ensembl_gene_id: R06C7.8.1
symbol: bub-1
gene_biotype: protein_coding
description:
  Mitotic checkpoint serine/threonine-protein kinase bub-1; Serine/threonine-protein kinase essential for spindle- assembly checkpoint signaling. Plays a key role in the recruitment of the checkpoint proteins bub-3, mdf-1 and mdf-2 to unattached kinetochores. mdf-1 recruitment is independent of bub-1 kinase activity. Has a role in the correct kinetochore localization of the spindly-like protein spdl-1. In addition, during meiotic anaphase I, controls the recruitment of hcp- 1/2 and klp-19 to the ring-shaped domain formed between chromosomes. Involved in chromosome alignment, chromosome h [...]


ensembl_gene_id: R06F6.1.1
symbol: cdl-1
gene_biotype: protein_coding
description:
  Histone RNA hairpin-binding protein; Involved in histone pre-mRNA 3' processing. Required for chromosome condensation, progression of cell death and morphogenesis.


ensembl_gene_id: R06F6.2.1
symbol: vps-11
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion (By similarity). The HOPS complex is proposed to be recruited to Rab7 on the lat [...]


ensembl_gene_id: R06F6.5b.1
symbol: npp-19
gene_biotype: protein_coding
description:
  Nucleoporin NUP35; Functions as a component of the nuclear pore complex (NPC) (By similarity). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors (By similarity). Required for the proper organization of chromosomes on the mitotic spindle during anaphase.


ensembl_gene_id: R06F6.8b.1
symbol: R06F6.8
gene_biotype: protein_coding
description:
  Guanine nucleotide exchange factor subunit R06F6.8; Probable component of a guanine nucleotide exchange factor (GEF) that may be required for efficient fusion of endosome-derived vesicles with the Golgi; Belongs to the RIC1 family.


ensembl_gene_id: R07A4.1.1
symbol: egl-36
gene_biotype: protein_coding
description:
  Potassium voltage-gated channel protein egl-36; Voltage-dependent potassium channel involved in the excitation of muscles operating egg-laying and defecation. Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Shaw sub-subfamily.


ensembl_gene_id: R07B1.1.1
symbol: vab-15
gene_biotype: protein_coding
description:
  Homeobox protein vab-15; Probable transcription factor needed for the proper production of touch cell precursors. Essential for embryonic morphogenesis.


ensembl_gene_id: R07B1.4.1
symbol: gst-36
gene_biotype: protein_coding
description:
  Probable glutathione S-transferase gst-36; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles; Belongs to the GST superfamily. Sigma family.


ensembl_gene_id: R07B7.5.1
symbol: kmo-1
gene_biotype: protein_coding
description:
  Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.


ensembl_gene_id: R07D5.1d.1
symbol: unc-7
gene_biotype: protein_coding
description:
  Innexin unc-7; Structural component of the gap junctions (By similarity). Required for coordinated locomotion. Probably by regulating neuronal transmission downstream of lin-3 and receptor lin- 23 and phospholipase plc-3 in ALA neurons, involved in the decrease in pharyngeal pumping during the quiescent state that precedes each larval molt.


ensembl_gene_id: R07E4.4.1
symbol: mig-23
gene_biotype: protein_coding
description:
  Nucleoside-diphosphatase mig-23; Seems to be able to hydrolyze ADP, UDP and GDP. Supports mig- 17 glycosylation and surface expression, which is required for proper migration of distal tip cells during gonad morphogenesis.


ensembl_gene_id: R07E4.6c.1
symbol: kin-2
gene_biotype: protein_coding
description:
  cAMP-dependent protein kinase regulatory subunit; Controls the rhythmic contraction of enteric muscles probably by regulating G-protein coupled receptor aex-2-mediated calcium influx in GABAergic DVB neurons; Belongs to the cAMP-dependent kinase regulatory chain family.


ensembl_gene_id: R07E5.13.1
symbol: mpc-1
gene_biotype: protein_coding
description:
  Probable mitochondrial pyruvate carrier 1; May mediate the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.


ensembl_gene_id: R07E5.14.1
symbol: rnp-4
gene_biotype: protein_coding
description:
  RNA-binding protein 8A; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.


ensembl_gene_id: R07E5.19.1
symbol: R07E5.19
gene_biotype: protein_coding
description:
  Vacuolar ATPase assembly integral membrane protein VMA21 homolog; Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum; Belongs to the VMA21 family.


ensembl_gene_id: R07E5.2.1
symbol: prdx-3
gene_biotype: protein_coding
description:
  Probable peroxiredoxin prdx-3; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events; Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.


ensembl_gene_id: R07G3.1.1
symbol: cdc-42
gene_biotype: protein_coding
description:
  Cell division control protein 42 homolog; Plays an essential role in spindle orientation and organizing cellular and embryonic polarity by controlling the localization and activity of PAR (partitioning-defective) proteins. Required for maintaining the asymmetric cortical localization of the anterior complex proteins par-3 and par-6, the posterior cortical protein par-2, and pkc-3. Involved in hypodermal cell fusion, together with pak-1 and ced-10, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. During gonad morphogenesis, plays a role in dista [...]


ensembl_gene_id: R07G3.5.1
symbol: pgam-5
gene_biotype: protein_coding
description:
  Serine/threonine-protein phosphatase Pgam5, mitochondrial; Displays phosphatase activity for serine/threonine residues. Has apparently no phosphoglycerate mutase activity (By similarity). Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily.


ensembl_gene_id: R07G3.6.1
symbol: osm-8
gene_biotype: protein_coding
description:
  Osmotic avoidance abnormal protein 8; Negative regulator of the osmotic stress response. Acts via the transmembrane protein ptr-23.


ensembl_gene_id: R07G3.9.1
symbol: oig-4
gene_biotype: protein_coding
description:
  Immunoglobulin domain-containing protein oig-4; Required for the localization of acetylcholine receptors at neuromuscular junctions and for subsequently controlling the response evoked by receptor stimulation.


ensembl_gene_id: R08C7.10b.1
symbol: wapl-1
gene_biotype: protein_coding
description:
  Wings apart-like protein homolog 1; Regulator of meiotic chromosome structure and function, playing a role in sister chromatid cohesion, possibly via antagonizing the coh-3/-4 association with axial elements in nuclei during late prophase, cohesin association with chromatin, DNA double strand break repair and polar body positioning following meiotic divisions during oogenesis. Regulates the morphogenesis and temporal assembly of axial elements to control the organization of meiotic chromosomes in pachytene nuclei and is also involved in meiotic chromosomal remodeling in late pachytene  [...]


ensembl_gene_id: R08C7.2a.2
symbol: chat-1
gene_biotype: protein_coding
description:
  CDC50 family protein chat-1; Probable chaperone protein for the phospholipid-transporting ATPase tat-1. Regulates cell membrane structure and function. Plays a role in maintaining the membrane phosphatidylserine asymmetry and the formation of the tubular membrane structure. Involved in membrane trafficking and is specifically involved in the recycling and degradation of endocytic cargo and this is likely with the phospholipid-transporting ATPase tat-1.


ensembl_gene_id: R08C7.3.3
symbol: htz-1
gene_biotype: protein_coding
description:
  Histone H2A.V; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). Required to maintain non-distal tip cell (DTC) fate of somatic gonadal  [...]


ensembl_gene_id: R08D7.2.2
symbol: rpap-2
gene_biotype: protein_coding
description:
  Putative RNA polymerase II subunit B1 CTD phosphatase rpap-2; Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation. Belongs to the RPAP2 family.


ensembl_gene_id: R08D7.3.1
symbol: eif-3.D
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 3 subunit D; mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7- methylguanosine cap of a subset of mRNAs.


ensembl_gene_id: R08D7.6a.1
symbol: pde-2
gene_biotype: protein_coding
description:
  Probable 3',5'-cyclic phosphodiesterase pde-2; May negatively regulate the activity of cGMP-dependent protein kinase egl-4 which in turn controls body size.


ensembl_gene_id: R08E3.4b.1
symbol: ztf-16
gene_biotype: protein_coding
description:
  Zinc finger protein ztf-16; Positively regulates the expression of ver-1 in the amphid sheath glia of amphid sensory neurons. Together with ehn-3, plays a role in somatic gonad development and is required for proper gonadal primordium assembly and somatic gonad precursor cell morphology ; Belongs to the Ikaros C2H2-type zinc-finger protein family.


ensembl_gene_id: R08E5.2.1
symbol: cysl-3
gene_biotype: protein_coding
description:
  Cysteine synthase 3; Primarily catalyzes the formation of cysteine and acetate from O-acetylserine and hydrogen sulfide. Can also catalyze the formation of cysteine and acetate from S-sulfocysteine and hydrogen sulfide and the formation of cyanoalanine and hydrogen sulfide from either S-sulfocysteine or O-acetylserine and hydrogen cyanide. Belongs to the cysteine synthase/cystathionine beta- synthase family.


ensembl_gene_id: R08F11.1a.1
symbol: R08F11.1
gene_biotype: protein_coding
description:
  Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide.


ensembl_gene_id: R09A1.1a.1
symbol: ergo-1
gene_biotype: protein_coding
description:
  Piwi-like protein ergo-1; Argonaute protein required for gene silencing in the endogenous RNA interference (RNAi) pathway. Involved in the 26G RNAi pathway and associates with both unmethylated and methylated 26G small interfering RNAs (26G- siRNAs), which are a class of 26 nucleotide siRNAs that possess a guanine residue at the 5'-end. Associated 26G-siRNAs are methylated by the methyltransferase henn-1, which stabilizes the siRNAs. Association with 26G- siRNAs is required for the biogenesis of secondary 22G-siRNAs (a class of 22 nucleotide siRNAs that possess a triphosphorylated guan [...]


ensembl_gene_id: R09B3.4.1
symbol: ubc-12
gene_biotype: protein_coding
description:
  NEDD8-conjugating enzyme ubc-12; Accepts the ubiquitin-like protein NEDD8 from the uba-3-ula-1 E1 complex and catalyzes its covalent attachment to other proteins. Plays a role in male tail tip morphogenesis.


ensembl_gene_id: R09B3.5.1
symbol: mag-1
gene_biotype: protein_coding
description:
  Protein mago nashi homolog; Involved in hermaphrodite germline sex determination. May allow oogenesis by inhibiting the function of one or more of the masculinizing genes (fog, fem, and gld) which act during the fourth larval stage to promote transient sperm production in the hermaphrodite germline; Belongs to the mago nashi family.


ensembl_gene_id: R09B5.4.1
symbol: fpn-1.2
gene_biotype: protein_coding
description:
  Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.


ensembl_gene_id: R09E12.3.1
symbol: sti-1
gene_biotype: protein_coding
description:
  Stress-induced-phosphoprotein 1; Plays a role in gonad development. Up-regulates longevity and thermotolerance. Binds daf-21/hsp90 and inhibits its ATPase activity.


ensembl_gene_id: R09G11.1.1
symbol: sup-10
gene_biotype: protein_coding
description:
  Putative potassium channel regulatory protein sup-10; May contribute to coordination of muscle contraction as regulatory subunit of a nonessential potassium channel complex.


ensembl_gene_id: R09H10.3a.1
symbol: R09H10.3
gene_biotype: protein_coding
description:
  Probable 5-hydroxyisourate hydrolase R09H10.3; Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo- 4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.


ensembl_gene_id: R102.5b.1
symbol: allo-1
gene_biotype: protein_coding
description:
  Allophagy receptor allo-1; Autophagy receptor, which is required for allophagy, an autophagic process in which paternal organelles, including mitochondria and membranous organelles, are degraded in early embryos. After fertilization, recruited to ubiquitin-modified paternal organelles and is required for the formation of autophagosomes around the paternal organelles. Also plays a role in the regulation of autophagy in germ cells.


ensembl_gene_id: R107.1b.1
symbol: nac-2
gene_biotype: protein_coding
description:
  Sodium-dependent high-affinity dicarboxylate transporter 2; High-affinity sodium-dicarboxylate cotransporter that accepts a range of tricarboxylic acid-cycle intermediates with 4-5 carbon atoms. There is no interaction with monocarboxylates (By similarity). Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.


ensembl_gene_id: R107.2.1
symbol: R107.2
gene_biotype: protein_coding
description:
  ATP-dependent (S)-NAD(P)H-hydrate dehydratase; Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Belongs to the NnrD/CARKD family.


ensembl_gene_id: R107.4b.1
symbol: ikke-1
gene_biotype: protein_coding
description:
  Inhibitor of nuclear factor kappa-B kinase epsilon subunit homolog 1; Serine/threonine-protein kinase, which plays a role in regulating allophagy, an autophagic process in which paternal organelles, including mitochondria and membranous organelles, are degraded in embryos. Phosphorylates the allophagy receptor allo-1, which is required for allophagy.


ensembl_gene_id: R107.6b.1
symbol: cls-2
gene_biotype: protein_coding
description:
  Protein CLASP-2; Probable microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Required for the formation of mitotic and meiotic spindles. Specifically promotes the polymerization of kinetochore-bound microtubules. Also required for cytoplasmic streaming. Essential for embryonic development.


ensembl_gene_id: R107.7.2
symbol: gst-1
gene_biotype: protein_coding
description:
  Glutathione S-transferase P; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (By similarity). Prevents dopaminergic CEP neuron degeneration in response to Mn(2+).


ensembl_gene_id: R107.8.1
symbol: lin-12
gene_biotype: protein_coding
description:
  Protein lin-12; Involved in several cell fate decisions that require cell- cell interactions. It is possible that lin-12 encodes a membrane-bound receptor for a signal that enables expression of the ventral uterine precursor cell fate. Activity in cell fate decisions and tumorigenesis is negatively regulated by sel-10. Functions in uterine cells to promote basement membrane mobility during tissue remodeling.


ensembl_gene_id: R10E11.1b.1
symbol: cbp-1
gene_biotype: protein_coding
description:
  Protein cbp-1; Acetyltransferase enzyme. Acetylates histones, giving a specific tag for transcriptional activation (By similarity). May prevent DNA damage-induced apoptosis by inhibiting cep-1-dependent transcription activation of the programmed cell death activator egl-1.


ensembl_gene_id: R10E11.2.1
symbol: vha-2
gene_biotype: protein_coding
description:
  V-type proton ATPase 16 kDa proteolipid subunit 2; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase (By similarity). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells (By similarity). Involved in necrotic cell death. Required along with other vacuolar ATPase components for the removal of protein aggregates which form in immature oocytes in the distal gonad. This removal occurs as the oocytes mature and move to the proximal gonad, is triggered by the introduction of sperm through mating and occ [...]


ensembl_gene_id: R10E11.3a.2
symbol: usp-46
gene_biotype: protein_coding
description:
  Ubiquitin carboxyl-terminal hydrolase 46; Regulates the abundance of the glr-1 glutamate receptor in the ventral nerve cord by promoting its deubiquitination and preventing its degradation in the lysosome. Contributes to the regulation of embryonic polarity.


ensembl_gene_id: R10E11.4.1
symbol: sqv-3
gene_biotype: protein_coding
description:
  Xylosylprotein 4-beta-galactosyltransferase; Glycosyltransferase required for the biosynthesis of the tetrasaccharide (GlcA-Gal-Gal-Xyl-)Ser core linker of heparan sulfate and chondroitin sulfate. Required for embryonic development. Involved in vulval epithelium invagination ; Belongs to the glycosyltransferase 7 family.


ensembl_gene_id: R10E11.8.1
symbol: vha-1
gene_biotype: protein_coding
description:
  V-type proton ATPase 16 kDa proteolipid subunit 1; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Required along with other vacuolar ATPase components for the removal of protein aggregates which form in immature oocytes in the distal gonad. This removal occurs as the oocytes mature and move to the proximal gonad, is triggered by the introduction of sperm through mating and occurs before fertilization. The introduction of sperm triggers V-AT [...]


ensembl_gene_id: R10E12.1b.1
symbol: alx-1
gene_biotype: protein_coding
description:
  Apoptosis-linked gene 2-interacting protein X 1; Required for lin-12 degradation after it has been internalised in the vulval precursor cells.


ensembl_gene_id: R10E4.4.2
symbol: mcm-5
gene_biotype: protein_coding
description:
  DNA replication licensing factor mcm-5; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentia [...]


ensembl_gene_id: R10E4.5d.1
symbol: nth-1
gene_biotype: protein_coding
description:
  Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family.


ensembl_gene_id: R10E4.9.1
symbol: R10E4.9
gene_biotype: protein_coding
description:
  Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors  [...]


ensembl_gene_id: R10H10.2.1
symbol: spe-26
gene_biotype: protein_coding
description:
  Spermatocyte protein spe-26; May play a role in the spermatocyte cytoskeleton, possibly interacting with actin.


ensembl_gene_id: R10H10.5.1
symbol: gpa-7
gene_biotype: protein_coding
description:
  Guanine nucleotide-binding protein alpha-7 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.


ensembl_gene_id: R11A5.2.1
symbol: nud-2
gene_biotype: protein_coding
description:
  Protein nud-2; Part of a complex with lis-1, which is recruited to the nuclear envelope by unc-83, where, in turn, it recruits dynein to the nuclear surface and regulates nuclear migration in hypodermal precursor cells. Plays a role in GABAergic synaptic vesicle localization in the ventral nerve cord ; Belongs to the nudE family.


ensembl_gene_id: R11A5.7.1
symbol: suro-1
gene_biotype: protein_coding
description:
  Putative carboxypeptidase suro-1; May play a role in processing or organization of cuticle collagen proteins, including rol-6 and col-19.


ensembl_gene_id: R11A8.4a.1
symbol: sir-2.1
gene_biotype: protein_coding
description:
  NAD-dependent protein deacetylase sir-2.1; NAD-dependent deacetylase (By similarity). Required for a reduction of the 'Lys-16' acetylation of histone H4 (H4K16ac) on dosage-compensated X chromosomes in hermaphrodites. Plays a role in germ cell and somatic cell apoptosis in response to DNA damage. Functions upstream of daf-16 in the insulin-like signaling pathway, promoting daf-16 mediated transcriptional activation and increased lifespan. May also regulate lifespan independently of daf-16 by modulating the transcription of genes involved in the stress response of the endoplasmic reticu [...]


ensembl_gene_id: R11D1.11.1
symbol: dhs-21
gene_biotype: protein_coding
description:
  L-xylulose reductase; Catalyzes the NADPH-dependent reduction of L-xylulose, D- xylulose, L-(+) erythrulose, D-erythrose, D-threose, L-ribulose, 1,4- dibromo-2,3-butanedione and 2,3-heptanedione. Also active against isatin, 9,10-phenanthrenequinone, menadione, 2,3- hexaenadione and 3,4-hexahenadione. No activity observed when tested using NADH rather than NADPH.


ensembl_gene_id: R11G1.4a.1
symbol: sax-1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase sax-1; Acts with sax-2 to restrict the growth of both primary and secondary neurites. Regulates mechanosensory tiling by controlling the termination point of sensory dendrites; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.


ensembl_gene_id: R12B2.4.1
symbol: him-10
gene_biotype: protein_coding
description:
  Kinetochore protein Nuf2 homolog; Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation in mitosis and meiosis and spindle checkpoint activity. The ndc-80 complex synergistically enhances the affinity of the ska-1 complex for microtubules and may allow the ndc-80 complex to track depolymerizing microtubules. Belongs to the NUF2 family.


ensembl_gene_id: R12B2.5a.1
symbol: mdt-15
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Require [...]


ensembl_gene_id: R12C12.1a.2
symbol: gldc-1
gene_biotype: protein_coding
description:
  Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine.


ensembl_gene_id: R12E2.10.1
symbol: egg-5
gene_biotype: protein_coding
description:
  Inactive protein-tyrosine phosphatase egg-5; Inactive phosphatase which acts redundantly with egg-4 in the oocyte-to-zygote transition. Required for polarized cortical actin cytoskeleton rearrangement in the oocyte before and after fertilization. Together with egg-4, required for the cortical localization of kinase mbk-2 in maturing oocyte until the end of meiosis I. Also required for kinase mbk-2, pseudophosphatase egg-3 and chitin synthase chs-1 localization to cytoplasmic foci after fertilization.


ensembl_gene_id: R12E2.11.2
symbol: R12E2.11
gene_biotype: protein_coding
description:
  Orotate phosphoribosyltransferase; Phosphoribosyltransferase which catalyzes the formation of UMP from uracil in vitro and thus may be involved in UMP biosynthesis via the salvage pathway. May also participate in the first step of UMP synthesis by catalyzing the formation of orotidine 5'-phosphate, a UMP precursor, from orotate.


ensembl_gene_id: R12E2.5.2
symbol: inx-16
gene_biotype: protein_coding
description:
  Innexin-16; Structural component of the gap junctions (By similarity). Required for signals downstream of defecation clock. Belongs to the pannexin family.


ensembl_gene_id: R12H7.2.1
symbol: asp-4
gene_biotype: protein_coding
description:
  Aspartic protease 4; Aspartic protease, which is part of the necrosis cell death pathway. Involved in neuronal cell degeneration. Involved in heat stress response. Belongs to the peptidase A1 family.


ensembl_gene_id: R134.1.1
symbol: gcy-3
gene_biotype: protein_coding
description:
  Receptor-type guanylate cyclase gcy-3; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity).


ensembl_gene_id: R134.2.1
symbol: gcy-2
gene_biotype: protein_coding
description:
  Receptor-type guanylate cyclase gcy-2; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity).


ensembl_gene_id: R13A5.12.1
symbol: lpd-7
gene_biotype: protein_coding
description:
  Pescadillo homolog; Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit; Belongs to the pescadillo family.


ensembl_gene_id: R13F6.10.1
symbol: cra-1
gene_biotype: protein_coding
description:
  N-terminal acetyltransferase B complex subunit NAA25 homolog; Non-catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of proteins beginning with Met-Asp or Met-Glu (By similarity). Required for chromosome organization and arrangement; specifically for assembly of the central region components of the synaptonemal complex onto chromosomes during meiosis and for DNA double stranded break formation and repair. Acts downstream of xnd-1 to regulate levels of histone acetylation in germ and somatic cell nuclei by controlling acetyl-CoA produ [...]


ensembl_gene_id: R13F6.4e.1
symbol: ten-1
gene_biotype: protein_coding
description:
  Teneurin-1; Plays a role in the gonadal basement membrane maintenance and/or adhesion early in development. Contributes to the guidance of pharyngeal neurons.


ensembl_gene_id: R13F6.9.1
symbol: sma-3
gene_biotype: protein_coding
description:
  Dwarfin sma-3; Involved in TGF-beta pathway. Plays a role in male tail tip morphogenesis ; Belongs to the dwarfin/SMAD family.


ensembl_gene_id: R13G10.1.1
symbol: dpy-27
gene_biotype: protein_coding
description:
  Chromosome condensation protein dpy-27; Central component of the condensin I-like dosage compensation complex that associates specifically with hermaphrodite X chromosomes to reduce their gene transcription throughout development. Its strong similarity with the condensin subunit smc4 suggests that it may reduce the X-chromosome transcript level by condensing the chromatin structure during interphase. Involved in the recruitment of the dosage compensation proteins mix-1 and dpy-21 to the X chromosome. Might be involved in the reduction of histone H4 lysine 16 acetylation (H4K16ac) on do [...]


ensembl_gene_id: R13G10.4.1
symbol: cnnm-5
gene_biotype: protein_coding
description:
  Metal transporter cnnm-5; Probable metal transporter. Probably acts redundantly with the other metal transport proteins cnnm-1, cnnm-2, cnnm-3 and cnnm-4 to regulate Mg(2+) homeostasis.


ensembl_gene_id: R13H4.4b.1
symbol: hmp-1
gene_biotype: protein_coding
description:
  Alpha-catenin-like protein hmp-1; Required for cell migration during body enclosure and cell shape changes during body elongation. Required for proper localization of other junctional components, such as pac-1 ; Belongs to the vinculin/alpha-catenin family.


ensembl_gene_id: R13H8.1h.1
symbol: daf-16
gene_biotype: protein_coding
description:
  Forkhead box protein O; Forkhead-type transcription factor. Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region. Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation. Longevity signaling predominantly arises from expression in the intestine. Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2. Inhibition is required for the carbon [...]


ensembl_gene_id: R144.5.1
symbol: smcr-8
gene_biotype: protein_coding
description:
  Guanine nucleotide exchange protein smcr-8; Part of a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy; Belongs to the SMCR8 family.


ensembl_gene_id: R144.7b.1
symbol: larp-1
gene_biotype: protein_coding
description:
  La-related protein 1; RNA-binding protein that promotes oogenesis by repressing fem-3 expression during germline development. Binds poly-U and poly-G stretches of RNA in vitro. Regulates target RNAs expression either by regulating their stability or translation.


ensembl_gene_id: R144.9.1
symbol: mdt-11
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 11; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).


ensembl_gene_id: R151.3.4
symbol: rpl-6
gene_biotype: protein_coding
description:
  60S ribosomal protein L6; Component of the large ribosomal subunit. Belongs to the eukaryotic ribosomal protein eL6 family.


ensembl_gene_id: R151.5a.1
symbol: dpy-31
gene_biotype: protein_coding
description:
  Zinc metalloproteinase dpy-31; Metalloprotease which cleaves the carboxyl terminus of procollagens, such as sqt-3, to mature collagens (By similarity). Involved in cuticular collagen maturation.


ensembl_gene_id: R151.6.1
symbol: R151.6
gene_biotype: protein_coding
description:
  Derlin-2; May be required for the degradation process of some specific misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Its precise function remains unclear, but its ability to complement der1 mutations in C.cerevisiae, suggests a similar function in the degradation of ER misfolded proteins.


ensembl_gene_id: R151.9.1
symbol: pfd-5
gene_biotype: protein_coding
description:
  Probable prefoldin subunit 5; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity); Belongs to the prefoldin subunit alpha family.


ensembl_gene_id: R153.1d.1
symbol: pde-4
gene_biotype: protein_coding
description:
  Probable 3',5'-cyclic phosphodiesterase pde-4; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (By similarity). Antagonizes dorsal D (DD) motor neuron respecification by reducing levels of cAMP.


ensembl_gene_id: R155.1a.1
symbol: mboa-6
gene_biotype: protein_coding
description:
  Lysophospholipid acyltransferase 5; Probable acyltransferase which may mediate the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (LPCAT activity). May also catalyze the conversion of lysophosphatidylethanolamine (1-acyl-2-hydroxy-sn-glycero-3- phosphoethanolamine or LPE) into phosphatidylethanolamine (1,2-diacyl- sn-glycero-3-phosphoethanolamine or PE) (LPEAT activity), as well as the conversion of lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero- 3-phospho-L-serine or LPS) in [...]


ensembl_gene_id: R160.1a.1
symbol: dpy-23
gene_biotype: protein_coding
description:
  AP-2 complex subunit mu; Component of the adaptor complexes which link clathrin to receptors in coated vesicles (By similarity). Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration (By similarity). AP50 is a subunit of the plasma membrane adaptor (By similarity). Essential wnt/egl-20 signaling protein that functions in wnt/egl-20-producing cells. Required for the AP-2 complex-mediated endocytosis of membrane proteins including wntless homolog mig-14 in egl-20-producing cells. During [...]


ensembl_gene_id: R160.7.1
symbol: lst-2
gene_biotype: protein_coding
description:
  Lateral signaling target protein 2; Negative regulator of epidermal growth factor receptor (EGFR) signaling; Belongs to the lst-2 family.


ensembl_gene_id: R166.4.1
symbol: pro-1
gene_biotype: protein_coding
description:
  Pre-rRNA-processing protein pro-1; Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit (By similarity). Required for processing ITS2 sequences from rRNA intermediates during 26S rRNA maturation. Required in the soma to promote normal proliferation and prevent germline tumor formation. Belongs to the WD repeat IPI3/WDR18 family.


ensembl_gene_id: R166.5b.1
symbol: mnk-1
gene_biotype: protein_coding
description:
  MAP kinase-interacting serine/threonine-protein kinase mnk-1; Serine/threonine-protein kinase which is required in the germline to regulate positively lifespan. May play a role in body wall muscle contraction. May be involved in embryonic cytokinesis.


ensembl_gene_id: R186.4.1
symbol: lin-46
gene_biotype: protein_coding
description:
  Molybdopterin molybdenumtransferase; Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.


ensembl_gene_id: R53.1a.2
symbol: flad-1
gene_biotype: protein_coding
description:
  Molybdenum cofactor biosynthesis protein-like region; Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme; In the N-terminal section; belongs to the MoaB/Mog family.


ensembl_gene_id: R53.4.1
symbol: R53.4
gene_biotype: protein_coding
description:
  Putative ATP synthase subunit f, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of  [...]


ensembl_gene_id: R53.6.2
symbol: psf-1
gene_biotype: protein_coding
description:
  Probable DNA replication complex GINS protein PSF1; The GINS complex plays an essential role in the initiation of DNA replication.


ensembl_gene_id: R74.1.1
symbol: lars-1
gene_biotype: protein_coding
description:
  Leucine--tRNA ligase; Involved in protein synthesis. Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.


ensembl_gene_id: R74.6.1
symbol: pelo-1
gene_biotype: protein_coding
description:
  Protein pelota homolog; Required for normal chromosome segregation during cell division and genomic stability. May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs. May have ribonuclease activity.


ensembl_gene_id: R74.7.1
symbol: R74.7
gene_biotype: protein_coding
description:
  Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.


ensembl_gene_id: T01A4.1c.1
symbol: gcy-28
gene_biotype: protein_coding
description:
  Receptor-type guanylate cyclase gcy-28; Guanylate cyclase involved in the production of the second messenger cGMP. Regulates olfactory perception in AWC sensory neurons although may not be involved in the primary sensory transduction steps. [Isoform d]: Regulates sensory integration of conflicting sensory cues in AIA interneurons.


ensembl_gene_id: T01B11.3.1
symbol: syx-4
gene_biotype: protein_coding
description:
  Putative syntaxin-4; Potentially involved in docking of synaptic vesicles at presynaptic active zones.


ensembl_gene_id: T01B11.4.1
symbol: ant-1.4
gene_biotype: protein_coding
description:
  Mitochondrial adenine nucleotide translocase 1.4; Belongs to the mitochondrial carrier (TC 2.A.29) family.


ensembl_gene_id: T01B7.4.1
symbol: cyn-11
gene_biotype: protein_coding
description:
  Peptidyl-prolyl cis-trans isomerase 11; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. PPIase H subfamily.


ensembl_gene_id: T01B7.7.2
symbol: rol-6
gene_biotype: protein_coding
description:
  Cuticle collagen rol-6; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Involved in body morphogenesis.


ensembl_gene_id: T01C1.2.1
symbol: mbr-1
gene_biotype: protein_coding
description:
  Mblk-1-related factor 1; May act as transcription activator (By similarity). Plays a role in neurogenesis by regulating neurite pruning between left and right AIM neurons and left and right RIF neurons during larval development. Regulates olfactory plasticity.


