# geneInfo

ensembl_gene_id: AC3.10.1
symbol: spe-10
gene_biotype: protein_coding
description:
  Palmitoyltransferase spe-10; Involved in spermatogenesis, specifically in the morphogenesis of fibrous body-membranous organelles (FB-MO), which are Golgi-derived organelles used for transporting sperm-specific components, in spermatocytes and in their localization into budding spermatids. Required for the proper formation of spermatids and spermatozoa.


ensembl_gene_id: AC7.2c.1
symbol: soc-2
gene_biotype: protein_coding
description:
  Leucine-rich repeat protein soc-2; Acts as a Ras effector and participates in MAPK pathway activation. Probably acts as a regulatory subunit of protein phosphatase that specifically dephosphorylates Raf kinase and stimulates Raf activity at specialized signaling complexes upon Ras activation. Required for vulval development. Involved in fluid homeostasis. Plays a role in nicotinic acetylcholine receptor (nAChR)-mediated sensitivity to nicotine.


ensembl_gene_id: AH6.1.1
symbol: gcy-1
gene_biotype: protein_coding
description:
  Receptor-type guanylate cyclase gcy-1; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Involved in the sensing of K+ gradient by the ASE right (ASER) sensory neuron.


ensembl_gene_id: AH6.2.1
symbol: sfxn-1.1
gene_biotype: protein_coding
description:
  Sideroflexin-1.1; Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway. Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors. Belongs to the sideroflexin family.


ensembl_gene_id: AH6.5.1
symbol: mex-6
gene_biotype: protein_coding
description:
  Zinc finger protein mex-6; Functions with mex-5 to affect embryonic viability, establish soma germline asymmetry in embryos and establish plk-1, pie-1, mex-1, and pos-1 asymmetry in embryos. Also affects formation of intestinal cells.


ensembl_gene_id: AH9.1.1
symbol: AH9.1
gene_biotype: protein_coding
description:
  Probable G-protein coupled receptor AH9.1; Not known. Putative receptor; Belongs to the G-protein coupled receptor 1 family.


ensembl_gene_id: AH9.2.1
symbol: crn-4
gene_biotype: protein_coding
description:
  Cell death-related nuclease 4; Involved in the degradation of chromosomal DNA. Contributes to cell killing.


ensembl_gene_id: AH9.4.1
symbol: AH9.4
gene_biotype: protein_coding
description:
  Probable G-protein coupled receptor AH9.4; Not known. Putative receptor; Belongs to the G-protein coupled receptor 1 family.


ensembl_gene_id: B0024.12.1
symbol: gna-1
gene_biotype: protein_coding
description:
  Glucosamine 6-phosphate N-acetyltransferase; Belongs to the acetyltransferase family. GNA1 subfamily.


ensembl_gene_id: B0024.13.1
symbol: B0024.13
gene_biotype: protein_coding
description:
  Polyprenol reductase; Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N- glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism (By similarity).


ensembl_gene_id: B0024.6b.1
symbol: gcy-6
gene_biotype: protein_coding
description:
  Receptor-type guanylate cyclase gcy-6; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Regulates chemotaxis responses toward the salt ion Mg(2+) and to a lesser extent toward Cl(1-) in ASE left (ASEL) sensory neuron.


ensembl_gene_id: B0024.8a.1
symbol: che-12
gene_biotype: protein_coding
description:
  Crescerin-like protein che-12; Required for normal structure and function of sensory cilia on amphid neurons, especially for the formation of distal ciliary structures, but is less important for normal assembly of middle and basal ciliary structures. Plays a role in the organization of axoneme microtubule bundles in sensory cilia. Required for normal structure and function of the ASER neuron that mediates attraction to NaCl. Required for normal chemotaxis to NaCl. Required for normal avoidance response to high osmolarity. In contrast, is not required for normal chemotaxis to isoamyl al [...]


ensembl_gene_id: B0024.9a.2
symbol: trx-2
gene_biotype: protein_coding
description:
  Probable thioredoxin-2; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.


ensembl_gene_id: B0025.1a.1
symbol: vps-34
gene_biotype: protein_coding
description:
  Phosphatidylinositol 3-kinase catalytic subunit type 3; Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate. Together with bec-1, mediates the production of phosphatidylinositol 3-phosphate on intracellular vesicles and thereby regulates membrane trafficking. Plays a role in endosome-to-Golgi retrograde transport of mig-14. Involved in clearance of apoptotic cell corpses by phagosomes. Phagosome maturation requires two sequential and non-overlapping pulses of phosphatidylinositol-3-phosphate (PI3P) on the vesicle surface which mediates recr [...]


ensembl_gene_id: B0025.2.1
symbol: csn-2
gene_biotype: protein_coding
description:
  COP9 signalosome complex subunit 2; Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. The CSN complex plays an essential role in embryogenesis and oogenesis and is required to regulate microtubule stability in the early embryo. Mediates mei-3/katanin targeting for degradation at the mei [...]


ensembl_gene_id: B0035.10.1
symbol: his-45
gene_biotype: protein_coding
description:
  Histone H3; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.


ensembl_gene_id: B0035.11.1
symbol: leo-1
gene_biotype: protein_coding
description:
  RNA polymerase-associated protein LEO1; Component of the PAF1 complex which is a multifunctional complex involved in transcription initiation via genetic interactions with TATA-binding proteins, elongation and transcription-coupled histone modification.


ensembl_gene_id: B0035.14a.2
symbol: dnj-1
gene_biotype: protein_coding
description:
  DnaJ homolog subfamily B member 1; Acts as a co-chaperone with Hsp70 required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum-associated degradation (ERAD) pathway (By similarity). Acts by determining Hsp70's ATPase and polypeptide-binding activities (By similarity). Can also act as a chaperone that promotes maturation of potassium channel unc-103 by stabilizing nascent channel subunits and assembling them into tetramers ; Belongs to the DnaJ family. DNAJB12/DNAJB14 subfamily.


ensembl_gene_id: B0035.16.1
symbol: mttu-1
gene_biotype: protein_coding
description:
  Probable mitochondrial tRNA-specific 2-thiouridylase 1; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base. Belongs to the MnmA/TRMU family.


ensembl_gene_id: B0035.4.2
symbol: pfd-4
gene_biotype: protein_coding
description:
  Probable prefoldin subunit 4; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity); Belongs to the prefoldin subunit beta family.


ensembl_gene_id: B0035.5.1
symbol: gspd-1
gene_biotype: protein_coding
description:
  Glucose-6-phosphate 1-dehydrogenase; Cytosolic glucose-6-phosphate dehydrogenase that catalyzes the first and rate-limiting step of the oxidative branch within the pentose phosphate pathway/shunt, an alternative route to glycolysis for the dissimilation of carbohydrates and a major source of reducing power and metabolic intermediates for fatty acid and nucleic acid biosynthetic processes.


ensembl_gene_id: B0035.7.1
symbol: his-47
gene_biotype: protein_coding
description:
  Histone H2A; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.


ensembl_gene_id: B0035.8.1
symbol: his-48
gene_biotype: protein_coding
description:
  Probable histone H2B 4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.


ensembl_gene_id: B0035.9.1
symbol: his-46
gene_biotype: protein_coding
description:
  Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.


ensembl_gene_id: B0041.6a.1
symbol: ptps-1
gene_biotype: protein_coding
description:
  Putative 6-pyruvoyl tetrahydrobiopterin synthase; Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin (By similarity); Belongs to the PTPS family.


ensembl_gene_id: B0041.7.2
symbol: xnp-1
gene_biotype: protein_coding
description:
  Transcriptional regulator ATRX homolog; Required for embryonic development and gonadogenesis. Also, functions redundantly with the transcriptional repressor lin-35 to regulate somatic gonad development.


ensembl_gene_id: B0205.3.2
symbol: rpn-10
gene_biotype: protein_coding
description:
  26S proteasome non-ATPase regulatory subunit 4; Binds and presumably selects ubiquitin-conjugates for destruction (By similarity). Required for protein degradation and ubiquitin-proteasome system (UBS) function and regulates proteasomal subunit expression. Involvement in UBS might be cell type specific. Regulator of the autophagy-lysosome pathway that may confer resistance to autophagy by regulating the expression of autophagy-related proteins such as lgg-1, and by regulating lysosome formation, possibly by modulating elt-2 activity. Required for fertility, sperm production, and sex de [...]


ensembl_gene_id: B0205.7.1
symbol: kin-3
gene_biotype: protein_coding
description:
  Casein kinase II subunit alpha; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. The alpha chain contains the catalytic site. May participate in Wnt signaling. Modulates two aspects of male mating behavior; response to hermaphrodite contact and vulval location, acting in the same pathway as lov-1 and pkd-2.


ensembl_gene_id: B0207.3b.1
symbol: gpa-14
gene_biotype: protein_coding
description:
  Guanine nucleotide-binding protein alpha-14 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems; Belongs to the G-alpha family.


ensembl_gene_id: B0207.4.1
symbol: air-2
gene_biotype: protein_coding
description:
  Aurora/IPL1-related protein kinase 2; Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of chromosome segregation and cytokinesis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation. Required for histone H3 phosphorylation during segregation of homologous chromosomes in meiosis and mitosis. Required for histone H3 'Ser- 10' phosphorylation. Phosphorylates tlk-1 at 'Ser-634', which enhances its activity. Phosphorylates zen-4 at 'Ser- 680'. Required f [...]


ensembl_gene_id: B0207.6.1
symbol: B0207.6
gene_biotype: protein_coding
description:
  GPN-loop GTPase 2; Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family.


ensembl_gene_id: B0213.3.1
symbol: nlp-28
gene_biotype: protein_coding
description:
  Neuropeptide-like protein 28; May have antimicrobial activity; Belongs to the YARP (YGGW-amide related peptide) family.


ensembl_gene_id: B0213.4.1
symbol: nlp-29
gene_biotype: protein_coding
description:
  Neuropeptide-like protein 29; Antimicrobial peptides that have antibacterial activity against the Gram-negative bacteria S.marcescens. Has antifungal activity against D.coniospora. May play a role in response to physical injury and osmotic stress ; Belongs to the YARP (YGGW-amide related peptide) family.


ensembl_gene_id: B0213.5.1
symbol: nlp-30
gene_biotype: protein_coding
description:
  Neuropeptide-like protein 30; May have antimicrobial activity. May play a role in response to fungal infection; Belongs to the YARP (YGGW-amide related peptide) family.


ensembl_gene_id: B0213.6.1
symbol: nlp-31
gene_biotype: protein_coding
description:
  Neuropeptide-like protein 31; Antimicrobial peptides that have antifungal activity against D.coniospora. Has weak antibacterial activity against Gram-positive bacteria M.luteus and Gram-negative E.coli.


ensembl_gene_id: B0218.1.4
symbol: faah-1
gene_biotype: protein_coding
description:
  Fatty acid amide hydrolase 1; Degrades bioactive fatty acid amides like palmitoyl ethanolamide (PEA), palmitoleoyl ethanolamide (POEA), oleoyl ethanolamide (OEA), linoleoyl ethanolamide (LOEA), arachidonoyl ethanolamide (anandamide, or AEA), and eicosapentaneoyl ethanolamide (EPEA), thereby serving to terminate the signaling functions of these molecules. EPEA promotes dauer formation and may constitute a signal of high nutrient availability. Breakdown of EPEA may promote lifespan extension when nutrient availability is high. Facilitates axon regeneration after injury by degradating inh [...]


ensembl_gene_id: B0218.3.1
symbol: pmk-1
gene_biotype: protein_coding
description:
  Mitogen-activated protein kinase pmk-1; Serine/threonine kinase which responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating downstream targets. Phosphorylates snk-1 which probably regulates skn-1 nuclear translocation in response to oxidative stress. Probably by activating skn-1, involved in the up- regulation of gcs-1 and glutathione-S-transferase gst-4 expression upon bacteria infection. Up-regulates expression of gcs-1 in intestinal cells upon arsenite treatment. Functions downstream of the MAPKK sek-1 and the MAPKKK nsy-1 as the MAP kinase [...]


ensembl_gene_id: B0222.2.1
symbol: pitr-2
gene_biotype: protein_coding
description:
  Phosphate transporter; Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport. Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.


ensembl_gene_id: B0222.7.1
symbol: col-145
gene_biotype: protein_coding
description:
  Putative cuticle collagen 145; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment (By similarity).


ensembl_gene_id: B0222.8.1
symbol: col-10
gene_biotype: protein_coding
description:
  Cuticle collagen 10; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment (By similarity).


ensembl_gene_id: B0222.9.1
symbol: gad-3
gene_biotype: protein_coding
description:
  Probable aldehyde oxidase gad-3; May be involved in the metabolism of 1-methylnicotinamide (MNA). Linked to regulation of longevity through generation of reactive oxygen species, where it probably functions in a pathway downstream of the sirtuin sir-2.1 and the nicotinamide N-methyltransferase anmt-1. Belongs to the xanthine dehydrogenase family.


ensembl_gene_id: B0228.5a.1
symbol: trx-1
gene_biotype: protein_coding
description:
  Thioredoxin-1; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Shown to facilitate the reduction of insulin disulfide bonds. Might play a role in the reversible nitrosylation of cysteine residues in target proteins, and thereby contributing to the response to intracellular nitric oxide. Shapes the ASJ sensory neuron biphasic response to nitric oxide (NO) exposure; trans-nitrosylation activity might inhibit calcium flux to the cytoplasm in ASJ neurons when exposed to  [...]


ensembl_gene_id: B0228.7.3
symbol: B0228.7
gene_biotype: protein_coding
description:
  S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.


ensembl_gene_id: B0240.1.1
symbol: rhr-2
gene_biotype: protein_coding
description:
  Ammonium_transp domain-containing protein; Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.


ensembl_gene_id: B0240.3a.1
symbol: daf-11
gene_biotype: protein_coding
description:
  Receptor-type guanylate cyclase daf-11; Guanylate cyclase involved in the production of the second messenger cGMP. In addition, regulates cGMP levels by controlling the transcription of 3',5'-cyclic phosphodiesterase pde-1 and pde-5 mRNAs. Involved in the olfactory, light and pheromone sensing pathways. Part of the chemosensory mechanism of the ASJ sensory neuron that controls dauer formation and dauer recovery. Promotes the calcium flux in ASJ sensory neurons in response to onset and removal of a nitric oxide (NO) stimulus and is thereby required for the behavioral avoidance response  [...]


ensembl_gene_id: B0240.4.1
symbol: npp-22
gene_biotype: protein_coding
description:
  Nucleoporin ndc-1; Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope; Belongs to the NDC1 family.


ensembl_gene_id: B0244.2.1
symbol: ida-1
gene_biotype: protein_coding
description:
  Receptor-type tyrosine-protein phosphatase-like ida-1; Regulates dense-core vesicle (DCV) trafficking and/or secretion. Probably by controlling DCV trafficking, plays a role in the AVG neuron-mediated formation of the right axon tract of the ventral nerve cord. Involved in locomotion by regulating acetylcholine release. Probably by controlling the secretion of FLP neuropeptides, regulates the turning step of male mating behavior. Plays a role in preventing dauer formation. Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily.


ensembl_gene_id: B0244.8.1
symbol: egg-1
gene_biotype: protein_coding
description:
  LDL receptor repeat-containing protein egg-1; Probable receptor which is required for the oocyte-to-zygote transition although its exact function is controversial. Redundantly with egg-2, seems to be required for fertilization probably by promoting the interaction or fusion between sperm and oocyte. Conversely, shown to be dispensable for fertilization but required together with egg-2 for the formation of a continuous and cohesive eggshell chitin layer by maintaining a homogenous distribution of chitin synthase chs-1 at the unfertilized oocyte cell membrane. Appears to recruit or maint [...]


ensembl_gene_id: B0252.2.2
symbol: asm-1
gene_biotype: protein_coding
description:
  Sphingomyelin phosphodiesterase 1; Converts sphingomyelin to ceramide. Belongs to the acid sphingomyelinase family.


ensembl_gene_id: B0252.3b.1
symbol: B0252.3
gene_biotype: protein_coding
description:
  Putative transporter B0252.3; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.


ensembl_gene_id: B0252.4b.1
symbol: cyn-10
gene_biotype: protein_coding
description:
  Peptidyl-prolyl cis-trans isomerase 10; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.


ensembl_gene_id: B0261.2a.1
symbol: let-363
gene_biotype: protein_coding
description:
  Target of rapamycin homolog; Serine/threonine-protein kinase that regulates the mRNA translation machinery, probably by modulating the activity of translation factors such as eIF-4G and eIF-2. It may have some protein kinase activity instead of lipid kinase activity. May play a role in P-granule degradation by autophagy in somatic cells during embryogenesis. Required, during larval development, for the establishment of the proper number of germline progenitors, probably upstream of rsks-1 and ife-1. Required for larval development. May act as a mediator of lifespan regulation by insuli [...]


ensembl_gene_id: B0272.1.1
symbol: tbb-4
gene_biotype: protein_coding
description:
  Tubulin beta-4 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.


ensembl_gene_id: B0272.2.1
symbol: memb-1
gene_biotype: protein_coding
description:
  Golgi SNAP receptor complex member 2 homolog memb-1; Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.


ensembl_gene_id: B0272.3.1
symbol: B0272.3
gene_biotype: protein_coding
description:
  Probable 3-hydroxyacyl-CoA dehydrogenase B0272.3; Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.


ensembl_gene_id: B0273.2.2
symbol: puf-7
gene_biotype: protein_coding
description:
  Pumilio domain-containing protein 7; RNA-binding protein that binds to the consensus sequence 5'- CUCUGUAUCUUGU-3' in mRNA 3'-UTRs and modulates mRNA expression and stability. Functions redundantly with puf-5 and puf-6 in oocyte formation and organization, early embryonic cell divisions, and repression of expression of glp-1 and other maternal mRNAs in late oogenesis.


ensembl_gene_id: B0273.4c.1
symbol: unc-5
gene_biotype: protein_coding
description:
  Netrin receptor unc-5; Receptor for netrin (unc-6) required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon migration is mediated by the secreted unc-6, which promotes attraction of neurons and axons through binding to the unc-40 receptor, while repulsion requires both unc-5 and unc-40 receptors. Involved in the ventral-dorsal and anterior-posterior migration of distal tip cells along the body, which may be mediated by Wnt receptor mom-5, ced- 10/Rac, ced-12/ELMO and mig-2/RhoG.


ensembl_gene_id: B0280.10a.1
symbol: pot-1
gene_biotype: protein_coding
description:
  Protection of telomeres homolog 1; Telomeric DNA-binding protein, which binds to single-stranded C-rich repeat sequences, with high specificity to the 5'-GCCTAA-3' sequence. Repeat sequence binding can be at the 5' or 3' telomeric end. May have a role in protecting the 5' end of the C-rich strand of the telomere. Acts redundantly with pot-2 to negatively regulate telomerase-mediated telomere extension. Also regulates telomere length by the telomerase-independent telomere maintenance pathway called ALT (alternative lengthening of telomeres). Through sun-1, anchors telomeres to the nucle [...]


ensembl_gene_id: B0280.12b.1
symbol: glr-2
gene_biotype: protein_coding
description:
  Glutamate receptor 2; L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of glutamate are mediated by a variety of receptors that are named according to their selective agonists. Required for response to mechanical and osmotic stimuli; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.


ensembl_gene_id: B0280.1a.1
symbol: ggtb-1
gene_biotype: protein_coding
description:
  Probable geranylgeranyl transferase type-2 subunit beta; Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal.


ensembl_gene_id: B0280.4.1
symbol: odd-1
gene_biotype: protein_coding
description:
  Protein odd-skipped-related 1; May function as transcription regulator (Probable). Essential for larval development. Required for morphogenesis and function of the digestive tract. Belongs to the Odd C2H2-type zinc-finger protein family.


ensembl_gene_id: B0280.5.1
symbol: cpg-2
gene_biotype: protein_coding
description:
  Chondroitin proteoglycan-2; Required for polar body extrusion during cytokinesis in embryo development. Affects cortical granule size. Has roles in meiotic chromosome segregation, osmotic barrier function and polarization in conjunction with cpg-2. Binds chitin.


ensembl_gene_id: B0280.8.1
symbol: nhr-10
gene_biotype: protein_coding
description:
  Nuclear hormone receptor family member nhr-10; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family.


ensembl_gene_id: B0280.9.1
symbol: B0280.9
gene_biotype: protein_coding
description:
  U3 small nucleolar RNA-associated protein 18 homolog; Involved in nucleolar processing of pre-18S ribosomal RNA. Belongs to the WD repeat UTP18 family.


ensembl_gene_id: B0285.1b.1
symbol: cdk-12
gene_biotype: protein_coding
description:
  Cyclin-dependent kinase 12; Cyclin-dependent kinase which displays CTD kinase activity: hyperphosphorylates 'Ser-2' in the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit, thereby acting as a key regulator of transcription elongation. Required for normal reproduction.


ensembl_gene_id: B0285.4.2
symbol: lcmt-1
gene_biotype: protein_coding
description:
  Leucine carboxyl methyltransferase 1; Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha- leucine ester residues; Belongs to the methyltransferase superfamily. LCMT family.


ensembl_gene_id: B0285.5.1
symbol: hse-5
gene_biotype: protein_coding
description:
  D-glucuronyl C5-epimerase; Converts D-glucuronic acid residues adjacent to N-sulfate sugar residues to L-iduronic acids (By similarity). Plays a role in the early migration of AQR and PQR neurons, which descend from the Q neuroblasts ; Belongs to the D-glucuronyl C5-epimerase family.


ensembl_gene_id: B0285.9.2
symbol: ckb-2
gene_biotype: protein_coding
description:
  Choline kinase B2; Catalyzes the first step in phosphatidylcholine biosynthesis. Phosphorylates choline.


ensembl_gene_id: B0286.3.1
symbol: pacs-1
gene_biotype: protein_coding
description:
  Phosphoribosylaminoimidazole-succinocarboxamide synthase; In the C-terminal section; belongs to the AIR carboxylase family. Class II subfamily.


ensembl_gene_id: B0302.1a.1
symbol: sid-3
gene_biotype: protein_coding
description:
  Tyrosine-protein kinase sid-3; Tyrosine-protein kinase which plays a role in RNA-mediated gene silencing by mediating import of double-stranded RNA (dsRNA) into cells. Not required for import of ingested dsRNA into intestinal cells but involved in subsequent export from intestinal cells to internal tissues.


ensembl_gene_id: B0303.15.1
symbol: mrpl-11
gene_biotype: protein_coding
description:
  Probable 39S ribosomal protein L11, mitochondrial; Belongs to the universal ribosomal protein uL11 family.


ensembl_gene_id: B0303.2.1
symbol: anmt-1
gene_biotype: protein_coding
description:
  Nicotinamide N-methyltransferase; Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions (By similarity). Involved in regulation of lifespan extension downstream of the sirtuin sir-2.1, probably through its role in nicotinic acid metabolism.


ensembl_gene_id: B0303.8.1
symbol: sdz-1
gene_biotype: protein_coding
description:
  Skn-1 dependent zygotic transcript 1 protein; May have a role in mesendoderm development during embryogenesis.


ensembl_gene_id: B0303.9.1
symbol: vps-33.1
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 33A; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways. Believed to act as a component of the putative HOPS endosomal tethering complex which is proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE- mediated membrane fusion. The HOPS complex is proposed to be recruited to rab-7 on the late endosomal membrane and to regulate lat [...]


ensembl_gene_id: B0304.1b.2
symbol: hlh-1
gene_biotype: protein_coding
description:
  Myoblast determination protein 1 homolog; Accumulation defines the body wall muscle cell fate during embryogenesis. Acts redundantly with fozi-1 to promote body wall muscle cell and coelomocyte specification in postembryonic mesoderm progenitors, probably through suppression of sem-2.


ensembl_gene_id: B0334.2a.1
symbol: twk-5
gene_biotype: protein_coding
description:
  TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.


ensembl_gene_id: B0334.8a.1
symbol: age-1
gene_biotype: protein_coding
description:
  Phosphatidylinositol 3-kinase age-1; Phosphatidylinositol 3-kinase homolog that regulates longevity and diapause. Promotes cell survival during embryonic development by recruiting akt-1/2 to the plasma membrane through the production of PtdIns(3,4,5)P3. Could function in the development or neuroendocrine signaling of the dauer pathway. Mediates susceptibility to enteropathogenic E.coli infection. May negatively regulate AYI interneuron neurite outgrowth. Plays a role in aversive olfactory learning when an odor is associated with food deprivation. Regulates this process by promoting the [...]


ensembl_gene_id: B0336.11a.1
symbol: hpo-28
gene_biotype: protein_coding
description:
  Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.


ensembl_gene_id: B0336.1a.1
symbol: wrm-1
gene_biotype: protein_coding
description:
  Armadillo repeat-containing protein wrm-1; Antagonistic role in the Wnt signaling pathway that operates in embryogenesis. When located at the cortex it has been shown to inhibit Wnt signaling during asymmetric cell division but when relocated to the nucleus it shows positive regulation. Has a role in blastomere signaling during endoderm specification. Activates lit-1- dependent kinase activity. Wrm-1/lit-1 complex promotes phosphorylation, down-regulation and subcellular relocation of pop-1. Can substitute for bar-1 indicating functional redundancy. Appears to have a role in centrosome [...]


ensembl_gene_id: B0336.2.3
symbol: arf-1.2
gene_biotype: protein_coding
description:
  ADP-ribosylation factor 1-like 2; GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. Involved in endoplasmic reticulum dynamics during embryogenesis. Also required for adult germline function. Plays a role in cell shedding during embryogenesis probably by promoting the endocytosis of cell adhesion molecules. During neurogenesis, involved in cell autonomous Q.p neuroblast asymmetric divisions that generate one precursor cell and one apoptotic cell, probably by controlling endocytosis.


ensembl_gene_id: B0336.8.1
symbol: lgg-3
gene_biotype: protein_coding
description:
  Ubiquitin-like protein atg-12; Ubiquitin-like protein involved in autophagy vesicles formation (By similarity). Conjugation with atg-5 through a ubiquitin- like conjugating system involving also atg-7 as an E1-like activating enzyme and atg-10 as an E2-like conjugating enzyme, is essential for its function (By similarity). Most likely a component of an atg-5-lgg- 3-atg-16 complex that promotes autophagosome formation by associating with lgg-2, but not lgg-1, at the preautophagosomal membrane. Probably, as part of an atg-5-lgg- 3-atg-16 complex, required for lgg-1 lipidation; the comple [...]


ensembl_gene_id: B0336.9d.1
symbol: swp-1
gene_biotype: protein_coding
description:
  Protein SWAP; It is a regulator of pre-mRNA splicing (and, possibly, of other RNA processing events). It may regulate its own expression at the level of RNA processing.


ensembl_gene_id: B0348.4d.1
symbol: egl-8
gene_biotype: protein_coding
description:
  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) which plays an important role in the regulation of intracellular signaling cascades (By similarity). Required in the nervous system to modulate neuronal activity. Facilitates synaptic transmission at neuromuscular junctions by regulating the release of acetylcholine from the motor neurons and thus affecting locomotion. Plays a role in efficient egg laying and defecation. Involved in axon regeneration  [...]


ensembl_gene_id: B0348.6b.1
symbol: ife-3
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 4E-3; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. All 5 eIF4E proteins bind monomethyl cap structures. Only ife-1, ife-2 and ife-5 bind trimethyl cap structures which result from trans-splicing. Translation of trimethyl cap structure mRNAs may be regulated by intracellular redox state; disulfide bonds change the width and depth of the cap-binding cavity determining selectivit [...]


ensembl_gene_id: B0361.5b.1
symbol: psd-1
gene_biotype: protein_coding
description:
  Phosphatidylserine decarboxylase proenzyme, mitochondrial; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.


ensembl_gene_id: B0361.6.1
symbol: B0361.6
gene_biotype: protein_coding
description:
  Putative methyltransferase B0361.6; Belongs to the class IV-like SAM-binding methyltransferase superfamily.


ensembl_gene_id: B0361.8.1
symbol: algn-11
gene_biotype: protein_coding
description:
  GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase; Mannosyltransferase involved in the last steps of the synthesis of Man5GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum. Catalyzes the addition of the 4th and 5th mannose residues to the dolichol-linked oligosaccharide chain.


ensembl_gene_id: B0365.1.1
symbol: acly-2
gene_biotype: protein_coding
description:
  ATP-citrate synthase; In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.


ensembl_gene_id: B0393.1.2
symbol: rps-0
gene_biotype: protein_coding
description:
  40S ribosomal protein SA; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.


ensembl_gene_id: B0395.1.1
symbol: nhx-1
gene_biotype: protein_coding
description:
  Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.


ensembl_gene_id: B0395.3.2
symbol: B0395.3
gene_biotype: protein_coding
description:
  Carn_acyltransf domain-containing protein; Belongs to the carnitine/choline acetyltransferase family.


ensembl_gene_id: B0403.2.2
symbol: ubc-17
gene_biotype: protein_coding
description:
  Probable ubiquitin-conjugating enzyme protein 17; Belongs to the ubiquitin-conjugating enzyme family.


ensembl_gene_id: B0403.4.1
symbol: pdi-6
gene_biotype: protein_coding
description:
  Protein disulfide-isomerase A6 homolog; May function as a chaperone that inhibits aggregation of misfolded proteins (By similarity). May negatively regulate the unfolded protein response (UPR) through binding to UPR sensors ; Belongs to the protein disulfide isomerase family.


ensembl_gene_id: B0412.2.1
symbol: daf-7
gene_biotype: protein_coding
description:
  Dauer larva development regulatory growth factor daf-7; May act as a negative regulator of dauer larva development by transducing chemosensory information from ASI neurons. Involved in sensitivity to CO2 levels.


ensembl_gene_id: B0414.3.1
symbol: hil-5
gene_biotype: protein_coding
description:
  Histone H1.5; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.


ensembl_gene_id: B0414.5.1
symbol: cpb-3
gene_biotype: protein_coding
description:
  Cytoplasmic polyadenylation element-binding protein 3; Cytoplasmic polyadenylation element binding protein that binds to and regulates the translation of specific mRNAs (By similarity). May not be required for oogenesis.


ensembl_gene_id: B0414.6.1
symbol: glh-3
gene_biotype: protein_coding
description:
  ATP-dependent RNA helicase glh-3; Probable ATP-binding RNA helicase; Belongs to the DEAD box helicase family. DDX4/VASA subfamily.


ensembl_gene_id: B0414.8a.1
symbol: vps-51
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 51 homolog; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex facilitates tethering as well as SNARE complex assembly at the Golgi. Plays a role in the trafficking of cargo to dense-core vesicles, probably through association with the EARP-interacting protein eipr-1. Important for neuronal function. Belongs to the VPS51 family.


ensembl_gene_id: B0416.6.1
symbol: gly-13
gene_biotype: protein_coding
description:
  Putative alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase; Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans (By similarity); Belongs to the glycosyltransferase 13 family.


ensembl_gene_id: B0432.2.1
symbol: djr-1.1
gene_biotype: protein_coding
description:
  Glutathione-independent glyoxalase DJR-1.1; Catalyzes the conversion of methylglyoxal (MG) or glyoxal (GO) to D-lactate or glycolic acid respectively in a single glutathione (GSH)-independent step. May play a role in detoxifying endogenously produced glyoxals. Involved in protection against glyoxal-induced cell death.


ensembl_gene_id: B0432.3.1
symbol: mrpl-41
gene_biotype: protein_coding
description:
  39S ribosomal protein L41, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mL41 family.


ensembl_gene_id: B0432.4.1
symbol: misc-1
gene_biotype: protein_coding
description:
  Mitochondrial 2-oxoglutarate/malate carrier protein; Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism (By similarity). Maintains mitochondrial fusion and fission events, and the organization and morphology of cristae. Furthermore, plays a role in the oxidative stress response regulating endo [...]


ensembl_gene_id: B0432.5a.1
symbol: cat-2
gene_biotype: protein_coding
description:
  Tyrosine 3-monooxygenase; Involved in the synthesis of catecholamines, such as dopamine. Has a role in serotonin signaling. Required for normal explorative and foraging behavior.


ensembl_gene_id: B0454.1.1
symbol: lin-8
gene_biotype: protein_coding
description:
  Protein lin-8; Acts as a synthetic multivulva class A (synMuvA) protein and redundantly inhibits lin-3/EGF expression to prevent inappropriate vulva induction.


ensembl_gene_id: B0457.1a.1
symbol: lat-1
gene_biotype: protein_coding
description:
  Latrophilin-like protein 1; Has a role in the establishment of anterior-posterior polarity in tissues during embryogenesis. Required for the alignment of the mitotic spindles and division planes. May have a role in cell death events. Required for normal defection and oocyte fertilization. Involved in sperm function. Operates in pharyngeal pumping during feeding. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.


ensembl_gene_id: B0464.2a.1
symbol: ctr-9
gene_biotype: protein_coding
description:
  RNA polymerase-associated protein CTR9; Component of the PAF1 complex which is a multifunctional complex involved in transcription initiation via genetic interactions with TATA-binding proteins, elongation and transcription-coupled histone modification (By similarity). Ctr-9 is required for epidermal microtubule organization during morphogenesis.


ensembl_gene_id: B0464.4a.2
symbol: bre-3
gene_biotype: protein_coding
description:
  Beta-1,4-mannosyltransferase bre-3; Glycosyltransferase with a proposed role in glycosphingolipid biosynthesis. Involved in susceptibility to pore-forming crystal toxins in conjunction with bre- 1, bre-2, bre-4 and bre-5. Involved in resistance to the nematotoxic C.cinerea galectin Cgl2. Has a role in determining brood size.


ensembl_gene_id: B0464.5a.2
symbol: spk-1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase spk-1; Required for embryogenesis and germline development in both adult hermaphrodites and males. SR-protein kinase (SRPK) that binds directly to and phosphorylates the RS domain of rsp-3/CeSF2 in vitro.


ensembl_gene_id: B0464.7.1
symbol: baf-1
gene_biotype: protein_coding
description:
  Barrier-to-autointegration factor 1; DNA-binding protein which plays an essential role in nuclear envelope formation. Required for normal chromosome segregation during mitosis. Associates with the nuclear lamina via its interaction with LEM domain containing proteins emr-1 and lem-2. In association with lem-3, plays a role in radiation-induced DNA damage repair response. Belongs to the BAF family.


ensembl_gene_id: B0464.9.1
symbol: B0464.9
gene_biotype: protein_coding
description:
  Probable protein phosphatase methylesterase 1; Demethylates proteins that have been reversibly carboxymethylated; Belongs to the AB hydrolase superfamily.


ensembl_gene_id: B0478.1a.1
symbol: jnk-1
gene_biotype: protein_coding
description:
  Stress-activated protein kinase jnk-1; Serine/threonine-protein kinase which responds to activation by environmental stress by phosphorylating a number of transcription factors such as daf-16, and thus regulates transcriptional activity. By phosphorylating daf-16, plays a role in daf-16 nuclear translocation in intestinal cells in response to environmental stresses such as heat and oxidative stresses. Downstream of jkk-1, may coordinate locomotion via type-D GABAergic motoneurons and regulates synaptic vesicle transport in conjunction with unc-16. Independently of jkk-1, may regulate s [...]


ensembl_gene_id: B0491.1.1
symbol: B0491.1
gene_biotype: protein_coding
description:
  GPI mannosyltransferase 1; Mannosyltransferase involved in glycosylphosphatidylinositol- anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN- acyl-PI during GPI precursor assembly.


ensembl_gene_id: B0491.2.1
symbol: sqt-1
gene_biotype: protein_coding
description:
  Cuticle collagen sqt-1; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. This is a collagen critical for organismal morphogenesis. Mutations in sqt-1 can lengthen, shorten, or helically twist the entire animal.


ensembl_gene_id: B0495.2a.1
symbol: cdk-11.1
gene_biotype: protein_coding
description:
  Cyclin-dependent kinase 11.1; Probable cyclin-dependent kinase whose activity is most likely regulated by the cyclin cyl-1/Cylin-L. Important for normal oocyte and sperm development; probably required during multiple stages of gametogenesis. Plays a role in the activation of RAS-ERK signaling in the germ line. Also acts partially redundantly with cdk-11.2 to ensure embryonic viability. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.


ensembl_gene_id: B0495.4.1
symbol: nhx-2
gene_biotype: protein_coding
description:
  Na(+)/H(+) exchanger protein 2; Na(+)/H(+) antiporter that promotes normal di- or tripeptide transporter function, recovery following the peptide-induced acidification of the intestinal cytoplasm and maintenance of the peptide-dependent intestinal pH homeostasis. Regulator of free fatty acid uptake from the diet together with the dipeptide transporter pept- 1. May play a timekeeper role in defecation cycle but is not necessary for pbo-4-dependent proton release. May play a role in the regulation of lifespan independent of the stress response pathway.


ensembl_gene_id: B0511.10.1
symbol: eif-3.E
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.


ensembl_gene_id: B0511.13b.1
symbol: B0511.13
gene_biotype: protein_coding
description:
  Metallophosphoesterase 1 homolog; Metallophosphoesterase required for transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI- anchor proteins; Belongs to the metallophosphoesterase superfamily. MPPE1 family.


ensembl_gene_id: B0511.9c.1
symbol: cdc-26
gene_biotype: protein_coding
description:
  Anaphase-promoting complex subunit CDC26; Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins. Developmental role in early embryogenesis and the metaphase to anaphase transition in meiosis and mitosis. Required for embryonic anterior-posterior axis formation. Belongs to the CDC26 family.


ensembl_gene_id: B0513.5a.1
symbol: prdh-1
gene_biotype: protein_coding
description:
  Proline dehydrogenase 1, mitochondrial; Converts proline to delta-1-pyrroline-5-carboxylate (By similarity). Through proline catabolism, promotes reactive oxygen species (ROS) production and the transcription of skn-1 target genes in response to bacterial infection by P.aeruginosa.


ensembl_gene_id: B0523.3.1
symbol: pgl-2
gene_biotype: protein_coding
description:
  P granule abnormality protein 2; Transient component of P-granule which is involved in germline development.


ensembl_gene_id: B0523.5.1
symbol: fli-1
gene_biotype: protein_coding
description:
  Protein flightless-1 homolog; May play a key role in embryonic cellularization by interacting with both the cytoskeleton and other cellular components.


ensembl_gene_id: B0545.1a.1
symbol: tpa-1
gene_biotype: protein_coding
description:
  Protein kinase C-like 1; Diacylglycerol (DAG)-dependent serine/threonine-protein kinase that phosphorylates a range of cellular proteins (Probable). Phosphorylates mlk-1, a component of the JNK pathway. Involved in axon regeneration after injury probably by activating the JNK pathway. Plays a role in resistance to fungal infection and in wound healing by promoting expression of antimicrobial peptide nlp- 29 in the epidermis downstream of gpa-12 and plc-3 and upstream of tir- 1-p38-like pathway. Probably by regulating neuronal transmission in ALA neurons, regulates the decrease in phary [...]


ensembl_gene_id: B0546.1.1
symbol: mai-2
gene_biotype: protein_coding
description:
  ATPase inhibitor mai-2, mitochondrial; Thought to be a regulatory component of the ATP-synthesizing complex in the mitochondria. Activity is pH dependent.


ensembl_gene_id: B0547.1.1
symbol: csn-5
gene_biotype: protein_coding
description:
  COP9 signalosome complex subunit 5; Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of  [...]


ensembl_gene_id: B0563.6a.1
symbol: B0563.6
gene_biotype: protein_coding
description:
  Probable G-protein coupled receptor B0563.6; Not known. Putative receptor; Belongs to the G-protein coupled receptor 1 family.


ensembl_gene_id: B0564.10b.1
symbol: unc-30
gene_biotype: protein_coding
description:
  Homeobox protein unc-30; Transcriptional regulator within D-type neurons that controls terminal differentiation. Required for the development and function of the 19 inhibitory GABAergic (gamma-aminobutyric-acid- secreting) D-type motor neurons, which control locomotion. Plays a role in regulating synapse formation in dorsal D (DD) and ventral D (VD) GABAergic motor neurons, possibly in part by regulating the expression of the neural regulator oig-1. Also required for expression of flp-13 in DD motor neurons. Plays a role in respecification of DD motor neurons through regulation of gene [...]


ensembl_gene_id: B0564.11.1
symbol: rde-11
gene_biotype: protein_coding
description:
  RNA interference defective protein 11; In complex with rde-10, required in the endogenous and exogenous siRNA pathway for biogenesis and accumulation of secondary small interfering RNA (siRNA) intermediates, such as 22G-siRNAs derived from ergo-1 targets.


ensembl_gene_id: B0564.1a.1
symbol: exos-4.1
gene_biotype: protein_coding
description:
  Putative exosome complex component RRP41; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events; Belongs to the RNase PH family.


ensembl_gene_id: B0564.1b.2
symbol: tin-9.2
gene_biotype: protein_coding
description:
  Mitochondrial import inner membrane translocase subunit Tim10B; Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as the external driving force. In the TIM22 complex, it may act as a docking point for the soluble 70 kDa complex that guides the target proteins in transit through the aqueous mitochondrial intermembrane space (By similarity).


ensembl_gene_id: BE10.2.1
symbol: agmo-1
gene_biotype: protein_coding
description:
  Alkylglycerol monooxygenase; Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids; Belongs to the sterol desaturase family. TMEM195 subfamily.


ensembl_gene_id: C01A2.7b.1
symbol: nlp-38
gene_biotype: protein_coding
description:
  Neuropeptide-like protein 38; Plays a role in several types of aversive gustatory associative learning including gustatory plasticity and salt avoidance learning. [MIP-1-2]: Neuropeptide ligand for the G-protein coupled receptor sprr-2.


ensembl_gene_id: C01B12.4.1
symbol: osta-1
gene_biotype: protein_coding
description:
  Organic solute transporter alpha-like protein 1; Probable transporter; Belongs to the OST-alpha family.


ensembl_gene_id: C01B7.6.1
symbol: rpm-1
gene_biotype: protein_coding
description:
  E3 ubiquitin-protein ligase rpm-1; Atypical E3 ubiquitin-protein ligase which specifically mediates ubiquitination of threonine and serine residues on target proteins, instead of ubiquitinating lysine residues (By similarity). Shows esterification activity towards both threonine and serine, with a preference for threonine, and acts via two essential catalytic cysteine residues that relay ubiquitin to its substrate via thioester intermediates (By similarity). Mediates ubiquitination and subsequent proteasomal degradation of target proteins, including dlk-1. Negatively regulates a p38 MA [...]


ensembl_gene_id: C01C10.3.1
symbol: acl-12
gene_biotype: protein_coding
description:
  Putative 1-acyl-sn-glycerol-3-phosphate acyltransferase acl-12; Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.


ensembl_gene_id: C01C4.1.1
symbol: nlp-1
gene_biotype: protein_coding
description:
  Neuropeptide-like protein 1; In AWC olfactory sensory neurons, required for the detection of preferred food sources.


ensembl_gene_id: C01C7.1a.1
symbol: ark-1
gene_biotype: protein_coding
description:
  Ack-related non-receptor tyrosine kinase; Probable tyrosine protein kinase which plays a role in vulva development, probably by acting as a negative regulator of the let- 23/EGFR and let-60/ras pathway. Involved in the negative regulation of germline development.


ensembl_gene_id: C01F1.1.1
symbol: gtf-2F1
gene_biotype: protein_coding
description:
  Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family.


ensembl_gene_id: C01F6.4a.1
symbol: fem-3
gene_biotype: protein_coding
description:
  Sex-determination protein fem-3; Required for male development. In XO (male) animals, fem-3 directs male differentiation in all tissues. In XX (hermaphrodite) animals, it specifies the first 80 or so germ cells to be sperm. Negatively regulates male development when bound to tra-2. Together with fem-2 associates with the CBC(fem-1) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of tra-1.


ensembl_gene_id: C01F6.6b.1
symbol: nrfl-1
gene_biotype: protein_coding
description:
  Na(+)/H(+) exchange regulatory cofactor-like protein nrfl-1; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression (By similarity). Anchors the amino acid transporter protein aat-6 to the apical cell membrane of intestinal cells, particularly in older animals, in order to maintain amino acid homeostasis. May play a role in promoting fertility.


ensembl_gene_id: C01G10.10a.1
symbol: C01G10.10
gene_biotype: protein_coding
description:
  Probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 (By similarity). Involved in mitochondrial genome maintenance; Belongs to the KAE1 / TsaD family.


ensembl_gene_id: C01G10.9.2
symbol: C01G10.9
gene_biotype: protein_coding
description:
  Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.


ensembl_gene_id: C01G5.6.1
symbol: ddi-1
gene_biotype: protein_coding
description:
  Protein DDI1 homolog 1; Aspartic protease. Required for the cleavage and activation of transcription factors such as isoform a of the transcription factor skn-1, which in turn regulates the expression of proteasomal subunits such as rpt-3; Belongs to the DDI1 family.


ensembl_gene_id: C01G5.8a.1
symbol: fan-1
gene_biotype: protein_coding
description:
  Fanconi-associated nuclease 1 homolog; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family.


ensembl_gene_id: C01G6.6a.2
symbol: mtrr-1
gene_biotype: protein_coding
description:
  Methionine synthase reductase; Involved in the reductive regeneration of cob(I)alamin cofactor required for the maintenance of methionine synthase in a functional state.


ensembl_gene_id: C01G6.8a.1
symbol: cam-1
gene_biotype: protein_coding
description:
  Tyrosine-protein kinase receptor cam-1; Tyrosine-protein kinase receptor for Wnt ligands egl-20, mom- 2 and cwn-1. Involved in the final positioning of migrating ALM, CAN, BDU and HSN neurons during development. Involved in the anterior-posterior migration of QR neuroblast descendants, QR.p and QR.pa, by maintaining QR.p cell polarization, probably through mig-2. In addition, plays a role in ASI sensory neuron positioning and functions. Regulates asymmetric division of V cells (seam cells) and CA/CP neuroblast, and axon outgrowth. Probably by acting as a receptor for Wnt ligand cwn- 2, [...]


ensembl_gene_id: C01H6.5a.1
symbol: nhr-23
gene_biotype: protein_coding
description:
  Nuclear hormone receptor family member nhr-23; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family. NR1 subfamily.


ensembl_gene_id: C01H6.6.1
symbol: cnnm-4
gene_biotype: protein_coding
description:
  Metal transporter cnnm-4; Probable metal transporter. Probably acts redundantly with the other metal transport proteins cnnm-1, cnnm-2, cnnm-3 and cnnm-5 to regulate Mg(2+) homeostasis.


ensembl_gene_id: C02A12.4.1
symbol: lys-7
gene_biotype: protein_coding
description:
  Lysozyme-like protein 7; Plays a role in resistance to Gram-positive bacteria B.thuringiensis and M.nematophilum and Gram-negative bacteria S.boydii or S.flexneri infection and to fungus C.neoformans infection. Plays a role in susceptibility to Gram-negative bacterium S.typhimurium infection. Belongs to the glycosyl hydrolase 25 family.


ensembl_gene_id: C02B10.2.1
symbol: snpn-1
gene_biotype: protein_coding
description:
  SNAPIN protein homolog; Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in gut granule biogenesis. Belongs to the SNAPIN family.


ensembl_gene_id: C02B4.1.1
symbol: adt-1
gene_biotype: protein_coding
description:
  A disintegrin and metalloproteinase with thrombospondin motifs adt-1; Plays a role in ray morphogenesis in the male tail, probably by remodeling the extracellular matrix (ECM) in the cuticle.


ensembl_gene_id: C02B8.4.1
symbol: hlh-8
gene_biotype: protein_coding
description:
  Twist-related protein; Acts as a transcriptional regulator. Involved in postembryonic mesodermal cell fate specification. Activates ceh-24 and egl-15 during mesodermal patterning.


ensembl_gene_id: C02C2.3.1
symbol: cup-4
gene_biotype: protein_coding
description:
  Acetylcholine receptor-like protein cup-4; Thought to regulate endocytosis in coelomocytes through modulation of phospholipase C activity. Possible acetylcholine receptor; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.


ensembl_gene_id: C02C2.5.1
symbol: sup-18
gene_biotype: protein_coding
description:
  Iodotyrosine dehalogenase 1 homolog; May contribute to coordination of muscle contraction as regulatory subunit of the nonessential sup-9 potassium channel complex. May act downstream of sup-10.


ensembl_gene_id: C02C6.1b.1
symbol: dyn-1
gene_biotype: protein_coding
description:
  Dynamin; Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis (By similarity). Required for coelomocyte endocytosis. Involved in apoptotic cell phagocytosis. Required for recruitment of phosphatidylinositol 3- kinase piki-1 to phagosomes. May play a role in rab-5 recruitment to cell-corpses-containing phagosomes but not to endosomes. Required for embryonic and larval development. Belongs to the TRAFAC class dynamin-like GTPase supe [...]


ensembl_gene_id: C02D4.2e.1
symbol: ser-2
gene_biotype: protein_coding
description:
  Tyramine receptor Ser-2; G-protein coupled receptor for tyramine, a known neurotransmitter and neuromodulator and direct precursor of octopamine. The rank order of potency is tyramine > octopamine > dopamine > serotonin > epinephrine = norepinephrine.


ensembl_gene_id: C02D5.3.2
symbol: gsto-2
gene_biotype: protein_coding
description:
  Probable glutathione transferase omega-2; Exhibits glutathione-dependent thiol transferase activity. Has dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) (By similarity); Belongs to the GST superfamily. Omega family.


ensembl_gene_id: C02E11.1b.1
symbol: nra-4
gene_biotype: protein_coding
description:
  Nicotinic receptor-associated protein 4; Involved in the recognition and selection of protein complexes to exit the endoplasmic reticulum (ER). In muscles, regulates levamisole-sensitive nicotinic acetylcholine receptor (L-AChR) subunit composition, possibly by allowing only specific L-AChR subunit combinations to exit the ER. Specifically, may promote the inclusion of alpha subunit unc-38 into and the exclusion of unc-29 from L-AChR. Regulates L- AChR sensitivity to agonists such as nicotine and levamisole at neuro- muscular junctions.


ensembl_gene_id: C02E7.1a.1
symbol: catp-2
gene_biotype: protein_coding
description:
  Cation_ATPase_N domain-containing protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.


ensembl_gene_id: C02F12.1b.1
symbol: tsp-17
gene_biotype: protein_coding
description:
  Tetraspanin-17; Protects dopaminergic neurons against oxidative stress- induced neurodegeneration. May act partly via dopamine receptor dop-2 to negatively regulate dopamine reuptake transporter dat-1 activity. Also plays a role in modulating behaviors linked to dopamine signaling. Confers protection against oxidative stress in the whole body.


ensembl_gene_id: C02F12.3.1
symbol: snet-1
gene_biotype: protein_coding
description:
  Protein snet-1; Negatively regulates chemotaxis and olfactory plasticity which is the change from positive chemotaxis to dispersal after prolonged exposure to an odorant. May be down-regulated in response to pheromone exposure, resulting in promotion of olfactory plasticity.


ensembl_gene_id: C02F4.2b.1
symbol: tax-6
gene_biotype: protein_coding
description:
  Serine/threonine-protein phosphatase 2B catalytic subunit; Calcium-dependent, calmodulin-stimulated protein phosphatase. Dephosphorylates arrd-17. Dephosphorylates daf-16 at 'Ser-319' which regulates daf-16 nuclear translocation. Dephosphorylates calcium permeable cation channel pkd-2 at 'Ser-534'. Regulates male mating behavior including response to hermaphrodite contact and vulva location and localization of pkd-2 to neuronal cilium. Negatively regulates several sensory behaviors including thermotaxis in ADF neurons, osmosensation in ASH neurons, olfaction adaptation in AWC neurons a [...]


ensembl_gene_id: C02F5.1.1
symbol: knl-1
gene_biotype: protein_coding
description:
  Kinetochore null protein 1; Proposed to be part of the KMN network incorporating the MIS12 complex and NDC80 complex that is required for establishing the kinetochore-microtubule interface that aids in chromosome segregation during meiotic and mitotic cell division. Appears to function downstream of hcp-3 (CENP-A) and hcp-4 (CENP-C) in the kinetochore assembly hierarchy. Has a role in the correct localization of the spindly-like protein spdl-1 and the RZZ complex that is composed of rod-1, czw-1 and zwl-1 to kinetochores. Required for the recruitment of spindle-assembly checkpoint comp [...]


ensembl_gene_id: C02F5.3.1
symbol: C02F5.3
gene_biotype: protein_coding
description:
  Uncharacterized GTP-binding protein C02F5.3; Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.


ensembl_gene_id: C02F5.6b.1
symbol: henn-1
gene_biotype: protein_coding
description:
  Small RNA 2'-O-methyltransferase; Methyltransferase that adds a 2'-O-methyl group at the 3'-end of PIWI-interacting RNAs (piRNAs) and small interfering RNAs (siRNAs) which are classes of regulatory RNAs that are involved in gene silencing in endogenous RNA interference (RNAi) pathways. Methylation protects the 3'-end of small RNAs from tailing and trimming and could constitute a recognition signal for appropriate argonaute machineries (Probable). Methylates and stabilizes 26G-siRNAs (a class of 26 nucleotide siRNAs that possess a monophosphorylated guanine residue at the 5'-end) when t [...]


ensembl_gene_id: C02F5.7b.3
symbol: fbxl-1
gene_biotype: protein_coding
description:
  F-box/LRR-repeat protein fbxl-1; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (By similarity). Plays a role in regulating the entry into the dauer state. In hermaphrodites, may play a role in modulating the rate of defecation.


ensembl_gene_id: C02F5.9.1
symbol: pbs-6
gene_biotype: protein_coding
description:
  Proteasome subunit beta type-1; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).


ensembl_gene_id: C02H7.3a.1
symbol: aex-3
gene_biotype: protein_coding
description:
  MAP kinase-activating death domain protein; Plays a novel and significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Plays an important regulatory role in physiological cell death, caspase-mediated apoptosis (By similarity). Converts GDP-bound inactive form of rab-3 and cab-1 to the GTP-bound active forms. Regulator of presynaptic activity that interacts with rab-3 to regulate synaptic vesicle release. Is also a regulator of the cab-1 synaptic transmission pathway. Probably by converting rab-3 to its GTP-bound active form, plays a role  [...]


ensembl_gene_id: C03B8.4.1
symbol: lin-13
gene_biotype: protein_coding
description:
  Zinc finger protein lin-13; Involved in repression of vulval fate, possibly by a tumor suppressor protein Rb-mediated mechanism.


ensembl_gene_id: C03C10.1.1
symbol: kin-19
gene_biotype: protein_coding
description:
  Casein kinase I isoform alpha; Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.


ensembl_gene_id: C03C10.2.1
symbol: C03C10.2
gene_biotype: protein_coding
description:
  Putative casein kinase I C03C10.2; Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.


ensembl_gene_id: C03C10.3.1
symbol: rnr-2
gene_biotype: protein_coding
description:
  Ribonucleoside-diphosphate reductase small chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.


ensembl_gene_id: C03C10.4.1
symbol: rei-1
gene_biotype: protein_coding
description:
  Guanine nucleotide exchange factor rei-1; Guanine nucleotide exchange factor for Rab GTPase Rab-11.1. Spatially and temporally regulates the distribution of Rab-11.1 to target membranes during embryogenesis. Plays a role in cytokinesis, probably by targeting rab-11.1 to the cleavage furrows.


ensembl_gene_id: C03D6.3a.1
symbol: cel-1
gene_biotype: protein_coding
description:
  Polynucleotide 5'-triphosphatase; Bifunctional mRNA-capping enzyme exhibiting RNA 5'- triphosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the gmp moiety of GTP to the 5'-diphosphate terminus.


ensembl_gene_id: C03D6.4.1
symbol: npp-14
gene_biotype: protein_coding
description:
  Nuclear pore complex protein 14; May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex (By similarity). Plays a role in apoptosis by tethering caspase ced-3 to the nuclear membrane preventing its autoprocessing in absence of ced-4.


ensembl_gene_id: C03D6.5.1
symbol: asfl-1
gene_biotype: protein_coding
description:
  Probable histone chaperone asf-1-like protein; Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly.


ensembl_gene_id: C03D6.6.1
symbol: lab-1
gene_biotype: protein_coding
description:
  Long arms of the bivalent protein 1; Involved in sister chromatid cohesion during mitosis and meiosis. In association with the gsp-2 phosphatase, it both restricts the localization and antagonizes the function of the air-2 kinase during meiosis I and mitosis to promote chromatid cohesion and spindle attachment. This in turn, drives germ cell immortality. Furthermore, may play a role in ensuring the timely assembly of the synaptonemal complex during prophase I of meiosis.


ensembl_gene_id: C03D6.8.1
symbol: rpl-24.2
gene_biotype: protein_coding
description:
  Probable ribosome biogenesis protein RLP24; Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of NOG1 to pre-60S particles (By similarity).


ensembl_gene_id: C03F11.1.1
symbol: kcnl-3
gene_biotype: protein_coding
description:
  Small conductance calcium-activated potassium channel-like protein 3; Forms a voltage-independent potassium channel activated by intracellular calcium.


ensembl_gene_id: C03G5.1.1
symbol: sdha-1
gene_biotype: protein_coding
description:
  Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.


ensembl_gene_id: C03G5.7.1
symbol: flp-5
gene_biotype: protein_coding
description:
  FMRFamide-like neuropeptides 5; FMRFamides and FMRFamide-like peptides are neuropeptides. GAKFIRF-amide has an excitatory effect on dissected pharyngeal myogenic muscle system; Belongs to the FARP (FMRFamide related peptide) family.


ensembl_gene_id: C04A2.3a.1
symbol: egl-27
gene_biotype: protein_coding
description:
  Egg-laying defective protein 27; Transcription factor which promotes stress survival and delays aging. Required for cell cycle progression and development of the mesodermal and endodermal embryonic lineages. Required for normal T-cell polarity, for correct migration of QL neuroblast descendants and other cells, for embryonic patterning and for the embryonic expression of hlh-8. Also required for the transdifferentiation of the Y rectal epithelial cell to the PDA motor neuron during larval development.


ensembl_gene_id: C04C3.3.1
symbol: pdhb-1
gene_biotype: protein_coding
description:
  Pyruvate dehydrogenase E1 component subunit beta, mitochondrial; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).


ensembl_gene_id: C04C3.5b.1
symbol: dyf-3
gene_biotype: protein_coding
description:
  Clusterin-associated protein 1 homolog; Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. May be required for ciliary entrance and transport of specific ciliary cargo proteins such as che-3 which are related to motility. Required for sensory cilia biogenesis ; Belongs to the CLUAP1 family.


ensembl_gene_id: C04D8.1c.1
symbol: pac-1
gene_biotype: protein_coding
description:
  GTPase-activating protein pac-1; GTPase-activating protein for members of the Rho subfamily including Rac1, RhoA and cdc42 and other Ras-related subfamilies including let-60. Mediates radial (inner-outer) polarity and gastrulation by excluding par-6 from contacted cell surfaces; acts by inactivating cdc42 at inner cell surfaces which limits active cdc42 to outer cell surfaces devoid of cell-cell contacts, where cdc42 can bind and recruit par-6. Required for blastomere polarization.


ensembl_gene_id: C04E12.7.1
symbol: scrm-3
gene_biotype: protein_coding
description:
  Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family.


ensembl_gene_id: C04E7.2.1
symbol: sor-3
gene_biotype: protein_coding
description:
  Sop-2-related protein 3; Probably acts synergistically with sop-2 to maintain the transcriptionally repressive state of homeotic genes in order to regulate various neurogenic identities. Specification of some neuronal identities also involves expression of non-Hox genes. Specifies dopaminergic and serotonergic neuronal cell fate, and regulates neurotransmitter choice and axon pathfinding.


ensembl_gene_id: C04F12.10.1
symbol: fce-1
gene_biotype: protein_coding
description:
  CAAX prenyl protease 1 homolog; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family.


ensembl_gene_id: C04F5.1.2
symbol: sid-1
gene_biotype: protein_coding
description:
  Systemic RNA interference defective protein 1; Plays a role in RNA-mediated gene silencing by acting cell- autonomously as a channel for the transport of double-stranded RNA (dsRNA) between cells. Mediates the spread of dsRNA and subsequent silencing of genes in cells distant from the site of dsRNA introduction. Selective for dsRNA. Preferentially binds long dsRNA, from 50 base pairs up to 700. Short 20 base-pair long molecules are not bound. May also bind dsDNA, but with lower affinity. Binding may be sequence-independent. Belongs to the SID1 family.


ensembl_gene_id: C04F6.1.1
symbol: vit-5
gene_biotype: protein_coding
description:
  Vitellogenin-5; Precursor of the egg-yolk proteins that are sources of nutrients during embryonic development.


ensembl_gene_id: C04F6.4a.2
symbol: unc-78
gene_biotype: protein_coding
description:
  Actin-interacting protein 1; Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins. Regulator of actin organization in myofibrils.


ensembl_gene_id: C04G2.4.1
symbol: msp-36
gene_biotype: protein_coding
description:
  Major sperm protein 10/36/56/76; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.


ensembl_gene_id: C04G2.6.2
symbol: dis-3
gene_biotype: protein_coding
description:
  Probable exosome complex exonuclease RRP44; Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. dis-3 has both 3'-5' exonuclease and endonuclease activities (By similarity).


ensembl_gene_id: C04G6.1a.1
symbol: mpk-2
gene_biotype: protein_coding
description:
  Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.


ensembl_gene_id: C04H5.1.1
symbol: C04H5.1
gene_biotype: protein_coding
description:
  Multifunctional methyltransferase subunit TRM112-like protein; Acts as an activator of both RNA and protein methyltransferases.


ensembl_gene_id: C04H5.3.1
symbol: gcy-29
gene_biotype: protein_coding
description:
  Receptor-type guanylate cyclase gcy-29; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity).


ensembl_gene_id: C04H5.6a.1
symbol: mog-4
gene_biotype: protein_coding
description:
  Probable pre-mRNA-splicing factor ATP-dependent RNA helicase mog-4; ATP-binding RNA helicase involved in pre-mRNA splicing (Probable). Operates during embryogenesis.


ensembl_gene_id: C05B10.1b.1
symbol: lip-1
gene_biotype: protein_coding
description:
  Dual specificity protein phosphatase lip-1; Dephosphorylates MAP kinase mpk-1. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.


ensembl_gene_id: C05B5.7b.1
symbol: rgs-1
gene_biotype: protein_coding
description:
  Regulator of G-protein signaling rgs-1; Inhibits G protein signaling in nervous system, interacting preferentially with the G(O) subfamily member goa-1. In vitro, protein acts as a GTPase activator of goa-1. Rgs-1 and rgs-2 redundantly adjust signaling when worms are fed to allow rapid induction of egg-laying behavior.


ensembl_gene_id: C05C10.3.1
symbol: C05C10.3
gene_biotype: protein_coding
description:
  Probable succinyl-CoA:3-ketoacid coenzyme A transferase, mitochondrial; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.


ensembl_gene_id: C05C10.6b.1
symbol: ufd-3
gene_biotype: protein_coding
description:
  Ubiquitin fusion degradation protein 3 homolog; Plays a role in protein ubiquitination, sorting and degradation through its association with cdc-48.1 and/or cdc-48.2.


ensembl_gene_id: C05C8.2.1
symbol: krr-1
gene_biotype: protein_coding
description:
  KRR1 small subunit processome component; Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.


ensembl_gene_id: C05C8.9a.1
symbol: hyls-1
gene_biotype: protein_coding
description:
  Hydrolethalus syndrome protein 1 homolog; Plays an important role ciliogenesis. Belongs to the HYLS1 family.


ensembl_gene_id: C05D10.2a.1
symbol: mapk-15
gene_biotype: protein_coding
description:
  Mitogen-activated protein kinase 15; Atypical MAPK protein. Regulates primary cilium formation in sensory neurons and the localization of ciliary proteins involved in cilium structure, transport, and signaling. Acts in dopamine (DA) neurons to support synaptic membrane dat-1 availability via activation of rho-1 thereby sustaining normal levels of DA clearance. Plays a role in male mating behavior, probably in part through regulating the localization of the polycystin pkd-2. Functions postembryonically in the URX sensory neurons to constrain URX dendrite growth throughout lifetime, prob [...]


ensembl_gene_id: C05D10.3a.1
symbol: wht-1
gene_biotype: protein_coding
description:
  ABC transporter ATP-binding protein/permease wht-1; Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.


ensembl_gene_id: C05D11.12.2
symbol: let-721
gene_biotype: protein_coding
description:
  Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial; Accepts electrons from ETF and reduces ubiquinone. Belongs to the ETF-QO/FixC family.


ensembl_gene_id: C05D11.2.1
symbol: vps-16
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion (By similarity). The HOPS complex is proposed to be recruited to rab-7 on the la [...]


ensembl_gene_id: C05D11.3.1
symbol: txdc-9
gene_biotype: protein_coding
description:
  Thioredoxin domain-containing protein 9; Required for normal microtubule organization and function. Regulates tubulin acetylation in ALM and PLM neurons.


ensembl_gene_id: C05D11.4.1
symbol: let-756
gene_biotype: protein_coding
description:
  Protein let-756; Required for larval development. Probably by binding receptor egl-15, regulates negatively membrane protrusion from body wall muscles during larval development.


ensembl_gene_id: C05D11.5.1
symbol: C05D11.5
gene_biotype: protein_coding
description:
  Putative hydroxypyruvate isomerase; Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde); Belongs to the hyi family.


ensembl_gene_id: C05D11.7b.2
symbol: atgl-1
gene_biotype: protein_coding
description:
  Patanin-like phospholipase domain-containing protein; Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets (By similarity). May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion. Acts coordinately with lid-1 within the lipolytic cascade to distribute stored energy to tissues. Together with lipid droplet protein cgi-58, regulates lipid reserves as well as lipid droplet size and localization during t [...]


ensembl_gene_id: C05D2.1a.2
symbol: daf-4
gene_biotype: protein_coding
description:
  Cell surface receptor daf-4; Involved in TGF-beta pathway. May be a receptor for daf-7. Controls the dauer/nondauer developmental decision in a range of environmental conditions. Regulates body size and male tail patterning. Involved in regulating entry into quiescence triggered by satiety. Involved in sensitivity to CO2 levels. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.


ensembl_gene_id: C05D9.5.1
symbol: ife-4
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 4E-4; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. All 5 eIF4E proteins bind monomethyl cap structures. Only ife-1, ife-2 and ife-5 bind trimethyl cap structures which result from trans-splicing. Translation of trimethyl cap structure mRNAs may be regulated by intracellular redox state; disulfide bonds change the width and depth of the cap-binding cavity determining selectivit [...]


ensembl_gene_id: C05E11.1b.1
symbol: lnp-1
gene_biotype: protein_coding
description:
  Endoplasmic reticulum junction formation protein lunapark-1; Plays a role in tubular endoplasmic reticulum network formation and maintenance (By similarity). May be involved in central nervous system development. Has a presynaptic role in neurotransmission. Likely to operate in synaptogenesis by regulating vesicular transport or localization. Required for correct localization of rab-3 and snb-1; Belongs to the lunapark family.


ensembl_gene_id: C05E11.4.1
symbol: amt-1
gene_biotype: protein_coding
description:
  Putative ammonium transporter 1; Involved in the uptake of ammonia; Belongs to the ammonia transporter channel (TC 1.A.11.2) family.


ensembl_gene_id: C05E4.9a.2
symbol: icl-1
gene_biotype: protein_coding
description:
  Bifunctional glyoxylate cycle protein; In the C-terminal section; belongs to the malate synthase family.


ensembl_gene_id: C05G5.4.2
symbol: sucl-1
gene_biotype: protein_coding
description:
  Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.


ensembl_gene_id: C05H8.1b.1
symbol: ckk-1
gene_biotype: protein_coding
description:
  Calcium/calmodulin-dependent protein kinase kinase; Calcium/calmodulin-dependent protein kinase which phosphorylates cmk-1. Component of a calcium-triggered signaling cascade involved in CRE-mediated transcriptional activation, probably through cmk-1-mediated crh-1/CREB phosphorylation.


ensembl_gene_id: C06A1.1.1
symbol: cdc-48.1
gene_biotype: protein_coding
description:
  Transitional endoplasmic reticulum ATPase homolog 1; ATP-dependent chaperone which probably uses the energy provided by ATP hydrolysis to generate mechanical force to unfold substrate proteins, disassemble protein complexes, and disaggregate protein aggregates. Can also prevent aggregation of unfolded proteins also in an ATP- independent manner. Targets polyubiquitinated proteins for proteasomal degradation by binding to 'Lys-48'-linked polyubiquitin chains. Involved in the cytoplasmic elimination of misfolded proteins exported from the ER. This pathway, known as ERAD, prevents the act [...]


ensembl_gene_id: C06A1.5.1
symbol: rpb-6
gene_biotype: protein_coding
description:
  Probable DNA-directed RNA polymerases I, II, and III subunit RPABC2; DNA-dependent RNA polymerases catalyze the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RPB6 is part of t [...]


ensembl_gene_id: C06A12.4a.1
symbol: gcy-27
gene_biotype: protein_coding
description:
  Receptor-type guanylate cyclase gcy-27; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). May be involved in sensitivity to quinine by regulating egl-4 activity through the production of cGMP. Promotes the calcium flux to the cytoplasm in ASJ sensory neurons upon removal of a nitric oxide (NO) stimulus and is thereby involved in the behavioral avoidance response to NO-producing organisms like P.aeruginosa.


ensembl_gene_id: C06A5.7b.1
symbol: unc-94
gene_biotype: protein_coding
description:
  Tropomodulin; Acts as the pointed end capping protein which maintains the length and dynamics of the actin filament. Blocks the elongation and depolymerization of the actin filaments at the pointed end (By similarity); Belongs to the tropomodulin family.


ensembl_gene_id: C06A8.5.1
symbol: spdl-1
gene_biotype: protein_coding
description:
  Spindly-like protein spdl-1; Transient kinetochore component required for chromosome and spindle pole alignment and chromosome segregation during mitosis. Functions downstream of the RZZ complex to mediate kinetochore-microtubule attachments and nuclear envelope breakdown during cell division. Required for kinetochore assembly and localizes the checkpoint proteins mdf-1 and mdf-2, dynein and dynactin to unattached kinetochores. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end [...]


ensembl_gene_id: C06B3.4.1
symbol: stdh-1
gene_biotype: protein_coding
description:
  Putative steroid dehydrogenase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.


ensembl_gene_id: C06B3.5.1
symbol: stdh-3
gene_biotype: protein_coding
description:
  Putative steroid dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.


ensembl_gene_id: C06B3.8.1
symbol: gcy-32
gene_biotype: protein_coding
description:
  Soluble guanylate cyclase gcy-32; Synthesizes cyclic GMP (cGMP) from GTP (By similarity). Influences aerotaxis responses, aggregation and bordering behaviors (gathering around the edge of a bacterial lawn) in combination with other soluble guanylate cyclases.


ensembl_gene_id: C06B8.1.1
symbol: nhr-150
gene_biotype: protein_coding
description:
  Nuclear hormone receptor family member nhr-150; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family.


ensembl_gene_id: C06E1.10.1
symbol: rha-2
gene_biotype: protein_coding
description:
  Putative ATP-dependent RNA helicase rha-2; Probable ATP-binding RNA helicase; Belongs to the DEAD box helicase family. DEAH subfamily.


ensembl_gene_id: C06E1.3.1
symbol: doxa-1
gene_biotype: protein_coding
description:
  Dual oxidase maturation factor 1; Plays a role in cuticle biogenesis. In complex with tsp-15 and the dual oxidase bli-3, promotes the generation of reactive oxygen species (ROS) and tyrosine cross-linking of collagen, thus stabilizing cuticular extracellular matrix.


ensembl_gene_id: C06E1.4.1
symbol: glr-1
gene_biotype: protein_coding
description:
  Glutamate receptor 1; Non-NMDA (N-methyl-D-aspartate) ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of glutamate are mediated by a variety of receptors that are named according to their selective agonists. May contribute to a sensory discrimination between mechanical and chemical stimuli. Plays a role in controlling movement in response to environmental cues such as food availability and mechanosensory stimulation such as the nose touch response. In AIB interneurons, promotes om [...]


ensembl_gene_id: C06E2.3.1
symbol: ubc-21
gene_biotype: protein_coding
description:
  Probable ubiquitin-conjugating enzyme E2 21; Catalyzes the covalent attachment of ubiquitin to other proteins.


ensembl_gene_id: C06E7.1a.1
symbol: sams-3
gene_biotype: protein_coding
description:
  Probable S-adenosylmethionine synthase 3; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate; Belongs to the AdoMet synthase family.


ensembl_gene_id: C06E7.3a.2
symbol: sams-4
gene_biotype: protein_coding
description:
  Probable S-adenosylmethionine synthase 4; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate; Belongs to the AdoMet synthase family.


ensembl_gene_id: C06G3.11.1
symbol: tin-9.1
gene_biotype: protein_coding
description:
  Mitochondrial import inner membrane translocase subunit Tim9; Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (Probable). Belongs to the small Tim family.


ensembl_gene_id: C06G3.2.1
symbol: klp-18
gene_biotype: protein_coding
description:
  Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.


ensembl_gene_id: C06G3.7a.1
symbol: trxr-1
gene_biotype: protein_coding
description:
  Thioredoxin reductase 1; Together with glutathione reductase gsr-1, required for the reduction of disulfide groups in the cuticle during molting.


ensembl_gene_id: C06G3.9.2
symbol: ufl-1
gene_biotype: protein_coding
description:
  E3 UFM1-protein ligase 1 homolog; E3 UFM1-protein ligase that mediates ufmylation of target proteins.


ensembl_gene_id: C06G4.2a.2
symbol: clp-1
gene_biotype: protein_coding
description:
  Calpain clp-1; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates (By similarity). Required for assembly and maintenance of integrin attachment complexes which are essential for maintenance of adult muscle. Proteolytic activity is activated in response to increased intracellular Ca(2+) levels during cell degeneration and promotes necrotic cell death.


ensembl_gene_id: C06G4.5.1
symbol: npr-17
gene_biotype: protein_coding
description:
  Probable G-protein coupled receptor C06G4.5; Putative receptor; Belongs to the G-protein coupled receptor 1 family.


ensembl_gene_id: C06G8.2.2
symbol: pept-2
gene_biotype: protein_coding
description:
  Peptide transporter family 2; Proton-dependent uptake of di- or tripeptides, and to a minor extent tetrapeptides. Transport is independent of sodium and chloride ions. Protein shows high affinity to peptide substrates. Belongs to the PTR2/POT transporter (TC 2.A.17) family.


ensembl_gene_id: C06H2.4.1
symbol: folt-1
gene_biotype: protein_coding
description:
  Folate transporter 1; Folate transporter; Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.


ensembl_gene_id: C07A12.4a.1
symbol: pdi-2
gene_biotype: protein_coding
description:
  Protein disulfide-isomerase 2; Involved in cuticle formation. May play a role in the unfolded protein response. Belongs to the protein disulfide isomerase family.


ensembl_gene_id: C07A12.5a.1
symbol: spr-3
gene_biotype: protein_coding
description:
  Suppressor of presenilin protein 3; Probable transcriptional regulator, which participates in the transcriptional repression of the presenilin protein hop-1.


ensembl_gene_id: C07A9.3b.1
symbol: tlk-1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase tousled-like 1; Essential for appropriate transcription during embryonic development. May act during transcription elongation to activate the RNA polymerase II large subunit (ama-1) by phosphorylating the Ser-2 residues of the C-terminal domain 7-residue repeats. Does not phosphorylate histone H3.


ensembl_gene_id: C07B5.5.1
symbol: nuc-1
gene_biotype: protein_coding
description:
  Deoxyribonuclease-2; Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Implicated in apoptosis. Belongs to the DNase II family.


ensembl_gene_id: C07E3.1a.2
symbol: stip-1
gene_biotype: protein_coding
description:
  Septin and tuftelin-interacting protein 1 homolog; May be involved in pre-mRNA splicing (By similarity). Required for embryonic development and survival.


ensembl_gene_id: C07E3.2.1
symbol: pro-2
gene_biotype: protein_coding
description:
  Nucleolar complex protein 2 homolog; Required for normal somatic gonad development and for regulation of germline development and proliferation.


ensembl_gene_id: C07G1.1.1
symbol: svh-1
gene_biotype: protein_coding
description:
  Serine protease svh-1; Serine protease which ensures proper pharyngeal pumping during larval growth by regulating the levels of extracellular matrix component fbl-1. Independently of its enzymatic activity and probably by acting as a ligand for tyrosine-protein kinase receptor svh-2, involved in axon regeneration after injury by promoting the generation of productive and stable growth cones. May play a role in gonad development.


ensembl_gene_id: C07G1.3c.2
symbol: pct-1
gene_biotype: protein_coding
description:
  Cyclin-dependent kinase 17; Serine/threonine-protein kinase, which, in association with cyy-1, regulates the trafficking of synaptic vesicles in the DA9 motor neuron and probably also in the DD motor neurons and in RIA interneurons.


ensembl_gene_id: C07G2.1a.1
symbol: cpg-1
gene_biotype: protein_coding
description:
  Chondroitin proteoglycan 1; Required for polar body extrusion during cytokinesis in embryo development. Affects cortical granule size. Has roles in meiotic chromosome segregation, osmotic barrier function and polarization in conjunction with cpg-2. Binds chitin.


ensembl_gene_id: C07G2.3a.1
symbol: cct-5
gene_biotype: protein_coding
description:
  T-complex protein 1 subunit epsilon; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.


ensembl_gene_id: C07H6.3.1
symbol: cls-1
gene_biotype: protein_coding
description:
  Protein CLASP-1; Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (By similarity). Operates redundantly with cls-2 and cls-3 in regulating microtubule processes which position the spindle during asymmetric cell division.


ensembl_gene_id: C07H6.5.1
symbol: cgh-1
gene_biotype: protein_coding
description:
  ATP-dependent RNA helicase cgh-1; Probable RNA helicase required for oocyte and sperm function. Also required to prevent the physiological germline apoptosis mechanism killing essentially all developing oocytes. Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.


ensembl_gene_id: C07H6.6.1
symbol: clk-2
gene_biotype: protein_coding
description:
  Telomere length regulation protein clk-2; DNA damage checkpoint protein required for DNA damage-induced cell cycle arrest and apoptosis, thereby playing a role in genome stability. Regulator of telomere length. Belongs to the TEL2 family.


ensembl_gene_id: C07H6.7.2
symbol: lin-39
gene_biotype: protein_coding
description:
  Homeobox protein lin-39; Transcription factor that binds to the consensus 5'- TGATNNAT(G/T)(G/A)-3' PBC/Hox motif of target genes to regulate gene expression. Binds to the consensus PBC/Hox motif lineage enhancer region of sem-2 to promote cell fate specification in the postembryonic mesoderm (also known as the M lineage). Regulates the expression of mig-13 which controls the asymmetric distribution of actin cytoskeleton-binding protein cor-1 in Q neuroblasts. This in turn controls the polarity migration of Q neuroblasts and the subsequent mid-body region-specific development. Belongs  [...]


ensembl_gene_id: C08A9.1.1
symbol: sod-3
gene_biotype: protein_coding
description:
  Superoxide dismutase [Mn] 2, mitochondrial; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.


ensembl_gene_id: C08B11.1.2
symbol: zyg-11
gene_biotype: protein_coding
description:
  Early embryogenesis protein zyg-11; Acts as target recruitment subunit in the E3 ubiquitin ligase complex zyg-11-cul-2-elc-1. Required for metaphase to anaphase transition and M phase exit at meiosis II. Regulates polarity establishment.


ensembl_gene_id: C08B11.2.1
symbol: hda-2
gene_biotype: protein_coding
description:
  Putative histone deacetylase 2; Probably responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (By similarity). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). As a likely component of a histone deacetylase complex, together with saeg-1 and hda-2, functions downstream of the cAMP-dependent kinase e [...]


ensembl_gene_id: C08B11.4.1
symbol: nrf-6
gene_biotype: protein_coding
description:
  Nose resistant to fluoxetine protein 6; Plays a role in the uptake of a range of molecules including lipids and xenobiotic compounds from the intestine to surrounding tissues. Mediates transport of lipids from intestine to the reproductive tract. Required for efficient yolk transport into oocytes. Vital for embryonic development; Belongs to the acyltransferase 3 family.


ensembl_gene_id: C08B11.5.1
symbol: sap-49
gene_biotype: protein_coding
description:
  Splicing factor 3B subunit 4; Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. SF3B4 has been found in complex 'B' and 'C' as well. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron (By similarity).


ensembl_gene_id: C08B11.7.1
symbol: ubh-4
gene_biotype: protein_coding
description:
  Ubiquitin carboxyl-terminal hydrolase ubh-4; Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C- terminal glycine of ubiquitin; Belongs to the peptidase C12 family.


ensembl_gene_id: C08B11.8.1
symbol: C08B11.8
gene_biotype: protein_coding
description:
  Probable dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase; Adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation (By similarity). Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol (By similarity). Belongs to the ALG6/ALG8 glucosyltransferase family.


ensembl_gene_id: C08B6.7b.1
symbol: wdr-20
gene_biotype: protein_coding
description:
  WD repeat-containing protein 20 homolog; Together with wdr-48, binds to and stimulates the activity of the deubiquitinating enzyme usp-46, leading to deubiquitination and stabilization of the glr-1 glutamate receptor.


ensembl_gene_id: C08B6.9.1
symbol: aos-1
gene_biotype: protein_coding
description:
  SUMO-activating enzyme subunit aos-1; The dimeric enzyme acts as an E1 ligase for smo-1. It mediates ATP-dependent activation of smo-1 and formation of a thioester with a conserved cysteine residue on uba-2 (Probable).


ensembl_gene_id: C08C3.2b.1
symbol: bath-15
gene_biotype: protein_coding
description:
  BTB and MATH domain-containing protein 15; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.


ensembl_gene_id: C08C3.3.1
symbol: mab-5
gene_biotype: protein_coding
description:
  Homeobox protein mab-5; Transcription factor that binds to the promoter region of the transcription factor lin-39 to repress its expression in Q neuroblasts and thereby direct left Q neuroblast (QL) daughter cell migration. During postembryonic development, required for posterior-specific pattern formation. Within the posterior body region, controls epidermal, neuronal, and mesodermal cell differentiation. Belongs to the Antp homeobox family.


ensembl_gene_id: C08F8.1a.1
symbol: pfd-1
gene_biotype: protein_coding
description:
  Probable prefoldin subunit 1; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity). Has a role in gonadogenesis; Belongs to the prefoldin subunit beta family.


ensembl_gene_id: C08F8.2b.2
symbol: C08F8.2
gene_biotype: protein_coding
description:
  ATP-dependent RNA helicase SUV3 homolog, mitochondrial; ATPase and DNA/RNA helicase able to unwind DNA/DNA, DNA/RNA and RNA/RNA duplexes in the 5'-3' direction.


ensembl_gene_id: C08F8.8.1
symbol: nhr-67
gene_biotype: protein_coding
description:
  Nuclear hormone receptor family member nhr-67; Orphan nuclear receptor. In males, plays an essential role in the migration of the linker cell which guides gonad elongation during the L3 and L4 stages of larval development by negatively regulating the expression of netrin receptor unc-5 at the mid-L3 stage.


ensembl_gene_id: C08H9.3a.1
symbol: C08H9.3
gene_biotype: protein_coding
description:
  Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase; Adds the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol (By similarity).


ensembl_gene_id: C08H9.5.1
symbol: old-1
gene_biotype: protein_coding
description:
  Tyrosine-protein kinase receptor old-1; Receptor tyrosine kinase which plays a role in promoting longevity and resistance to stresses including UV irradiation and high temperatures, probably downstream of daf-16.


ensembl_gene_id: C09B8.1a.1
symbol: ipp-5
gene_biotype: protein_coding
description:
  Probable type I inositol 1,4,5-trisphosphate 5-phosphatase; Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type I family.


ensembl_gene_id: C09B8.7a.1
symbol: pak-1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase pak-1; Required for hypodermal cell fusion, together with cdc-42 and ced-10, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. Plays a redundant role with max-2 in dorsal axonal guidance in ventral cord commissural motoneurons and in P neuroblast migration. Acts probably downstream of Rho GTPases mig-2 and ced-10 to regulate these 2 processes. Involved in orientating axonal growth of HSN neurons. During gonad morphogenesis and probably in association with pix-1 and git-1, involved in the migration of distal tip ce [...]


ensembl_gene_id: C09B9.6.1
symbol: msp-55
gene_biotype: protein_coding
description:
  Major sperm protein 55/57; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.


ensembl_gene_id: C09C7.1.1
symbol: zig-4
gene_biotype: protein_coding
description:
  Zwei Ig domain protein zig-4; Required for maintaining axon position of PVQ and PVP neurons postembryonically in the ventral nerve cord (VNC) by preventing axons drifting into the opposite side of the VNC that could occur during body growth and movement.


ensembl_gene_id: C09D1.1b.1
symbol: unc-89
gene_biotype: protein_coding
description:
  Muscle M-line assembly protein unc-89; Structural component of the muscle M line which is involved in assembly and organization of sarcomere myofilaments. The large isoform a, isoform b, isoform d and isoform f play an essential role in maintaining the organization of sarcomeres but not myofilament alignment during body wall muscle development whereas the small isoform c and isoform d appear to have a minor role. Isoform b and isoform f are required for the organization of unc-15/paramyosin into sarcomere thick filaments in body wall muscles. By binding mel-26, a substrate adapter of t [...]


ensembl_gene_id: C09D4.1a.1
symbol: C09D4.1
gene_biotype: protein_coding
description:
  Uncharacterized MFS-type transporter C09D4.1; Belongs to the major facilitator superfamily. Feline leukemia virus subgroup C receptor (TC 2.A.1.28.1) family.


ensembl_gene_id: C09D8.1j.1
symbol: ptp-3
gene_biotype: protein_coding
description:
  Tyrosine-protein phosphatase Lar-like; Has a role in early neural and epidermal development; neuroblast movements during closure of the gastrulation cleft and epidermal morphogenesis. Vab-1 and ptp-3 may function redundantly within the same sets of neuronal precursors.


ensembl_gene_id: C09E7.3.1
symbol: oig-1
gene_biotype: protein_coding
description:
  Immunoglobulin domain-containing protein oig-1; Plays a role in neural development, where it temporally regulates synapse formation in the D-type inhibitory GABAergic motor neurons, dorsal D (DD) and ventral D (VD) motor neurons. Controls the translocation of postsynaptic proteins, such as the acetylcholine receptor subunit acr- 12, and presynaptic proteins, such as snb-1, along nerve cords to prevent premature synapse remodeling/formation.


ensembl_gene_id: C09F5.2a.1
symbol: orai-1
gene_biotype: protein_coding
description:
  Protein orai; Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel subunit which mediates Ca(2+) influx and increase in Ca(2+)-selective current by synergy with the Ca(2+) sensor, stim-1. Required for Ca(2+) and IP3-dependent contractile activity of sheath cells and the spermatheca. Affects brood size and somatic cell function. Belongs to the Orai family.


ensembl_gene_id: C09G12.8b.1
symbol: ced-10
gene_biotype: protein_coding
description:
  Ras-related protein ced-10; Required in engulfing to control the phagocytosis of apoptotic cell corpses. Required in embryonic development for the correct positioning and orientation of the mitotic spindles and division planes in blastomere cells. Involved in hypodermal cell fusion, together with pak-1 and cdc-42, leading to embryonic body elongation, which involves dramatic cytoskeletal reorganization. ced-2 and ced-5 function to activate ced-10 in a GTPase signaling pathway that controls the polarized extension of cell surfaces. Plays a redundant role with mig-2 in dorsal axonal guid [...]


ensembl_gene_id: C09G4.1b.1
symbol: hyl-1
gene_biotype: protein_coding
description:
  Ceramide synthase hyl-1; Catalyzes the acylation of sphingosine to form ceramides. Exhibits substrate preference for fatty acyl-coA chains containing 24 and 26 carbons.


ensembl_gene_id: C09G4.3.1
symbol: cks-1
gene_biotype: protein_coding
description:
  Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function (By similarity). Has a role in the exit from M phase during early mitotic cell division. More specifically, thought to act by degrading B-type cyclins that causes breakdown of nuclear envelope and exit mitosis; Belongs to the CKS family.


ensembl_gene_id: C09G4.5.1
symbol: mes-6
gene_biotype: protein_coding
description:
  Polycomb protein mes-6; Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. The mes-2/mes-3/mes- 6 complex may participate in the global inactivation of the X chromosomes in germline cells. The complex may act via methylation of histone H3 'Lys-27', rendering chromatin heritably changed in its expressibility. This complex is required to ex [...]


ensembl_gene_id: C09G5.1.1
symbol: ggr-1
gene_biotype: protein_coding
description:
  Glycine receptor subunit beta-type 4; Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Contributes to the generation of inhibitory postsynaptic currents.


ensembl_gene_id: C09G5.2a.1
symbol: dph-2
gene_biotype: protein_coding
description:
  2-(3-amino-3-carboxypropyl)histidine synthase subunit 2; Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2. Belongs to the DPH1/DPH2 family. DPH2 subfamily.


ensembl_gene_id: C09G5.3.1
symbol: col-79
gene_biotype: protein_coding
description:
  Putative cuticle collagen 79; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment (By similarity).


ensembl_gene_id: C09G5.4.1
symbol: col-39
gene_biotype: protein_coding
description:
  Cuticle collagen 39; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment (By similarity).


ensembl_gene_id: C09G5.5.1
symbol: col-80
gene_biotype: protein_coding
description:
  Putative cuticle collagen 80; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment (By similarity).


ensembl_gene_id: C09G5.6.1
symbol: bli-1
gene_biotype: protein_coding
description:
  Cuticle collagen bli-1; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. This collagen is required for proper strut formation within the unique medial layer of the adult cuticle.


ensembl_gene_id: C09G5.8a.1
symbol: mks-5
gene_biotype: protein_coding
description:
  Protein fantom; Thought to have an important role in cilia formation and cilia-mediated chemosensation. Involved in the docking of other MKS/MKSR proteins localized to the transition zone of the cilia. Belongs to the RPGRIP1 family.


ensembl_gene_id: C09G9.6.1
symbol: oma-1
gene_biotype: protein_coding
description:
  CCCH-type zinc finger protein oma-1; Zinc-finger RNA-binding protein that binds to 5'-UA[AU]-3' motifs in the 3'-UTR of maternal mRNAs to suppress translation in oocytes and embryos. Acts as a ribonucleoprotein particle component that may exert part of its function within cytoplasmic foci of unfertilized oocytes. Acts redundantly with oma-2 to control the temporal expression and distribution of maternal proteins and thereby promote meiotic progression, oocyte maturation, fertilization and embryonic development. Recruits the translational repressor ifet-1 to the 3'-UTR of mei-1 and zif- [...]


ensembl_gene_id: C09H10.3.1
symbol: nuo-1
gene_biotype: protein_coding
description:
  NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain.


ensembl_gene_id: C09H6.1a.1
symbol: spr-4
gene_biotype: protein_coding
description:
  Suppressor of presenilin protein 4; Probable transcriptional regulator, which participates in the transcriptional repression of the presenilin protein hop-1. Might play a role in the oxidative stress response.


ensembl_gene_id: C09H6.2a.1
symbol: lin-10
gene_biotype: protein_coding
description:
  Protein lin-10; Required specifically for the determination of 3 vulval precursor cell fates P5.p, P6.p and P7.p during late second and early third larval stages; required for basolateral localization of receptor tyrosine kinase let-23. Could have a general but redundant role in development, functioning in diverse cell lineages to control cell fates. Regulates the trafficking of the glutamate receptor glr-1 in the ventral nerve cord.


ensembl_gene_id: C09H6.3.1
symbol: mau-2
gene_biotype: protein_coding
description:
  Maternal uncoordinated protein 2; Required for association of the cohesin complex with chromatin during interphase. Involved in sister chromatid cohesion and normal progression through prometaphase. Required for normal development until the fourth larval stage. Functions cell autonomously to guide migrations during the development of the nervous system. Participates in the guidance of mechanosensory neuron AVM by a slt-1- independent mechanism. Regulates chromosome segregation in early embryos.


ensembl_gene_id: C10A4.8.1
symbol: mnm-2
gene_biotype: protein_coding
description:
  Zinc finger protein mnm-2; Required in the M3 pharyngeal motor neuron to guide the growth cone of the sister M2 motor neuron during axon development.


ensembl_gene_id: C10C6.6.1
symbol: catp-8
gene_biotype: protein_coding
description:
  Probable manganese-transporting ATPase catp-8; Mediates manganese transport into the endoplasmic reticulum. The ATPase activity is required for cellular manganese homeostasis.


ensembl_gene_id: C10E2.3a.1
symbol: hda-4
gene_biotype: protein_coding
description:
  Histone deacetylase 4; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). May be involved in muscle development.


ensembl_gene_id: C10F3.2.1
symbol: dhs-16
gene_biotype: protein_coding
description:
  3 beta-hydroxysteroid dehydrogenase dhs-16; 3 beta-hydroxysteroid dehydrogenase that converts 3 beta- hydroxysteroids to 3-ketosteroids, an essential step in the production of Delta(7)-dafachronic acid from cholesterol. Dafachronic acids bind directly to the nuclear hormone receptor (NHR) daf-12, suppressing dauer formation and inducing reproductive growth. Required for longevity in the absence of the germline. Belongs to the short-chain dehydrogenases/reductases (SDR) family.


ensembl_gene_id: C10F3.4b.1
symbol: mcp-1
gene_biotype: protein_coding
description:
  GDP-D-glucose phosphorylase 1; Specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells. Belongs to the GDPGP1 family.


ensembl_gene_id: C10F3.5a.1
symbol: pcm-1
gene_biotype: protein_coding
description:
  Protein-L-isoaspartate O-methyltransferase; Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. This enzyme does not act on D-aspartyl residues.


ensembl_gene_id: C10F3.6.2
symbol: fut-8
gene_biotype: protein_coding
description:
  Alpha-(1,6)-fucosyltransferase; Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. The addition is prevented if the GlcNAc residue is already fucosylated. Involved in susceptibility to the nematotoxic C.cinerea galectin Cgl2, likely by contributing to the synthesis of core alpha-1,6-fucosylated N-glycans to which Cgl2 binds.


ensembl_gene_id: C10G6.1a.2
symbol: egal-1
gene_biotype: protein_coding
description:
  Egalitarian protein homolog; Part of a complex with bicd-1 and dlc-1, which is recruited to the nuclear envelope by unc-83, where in turn, it recruits dynein to the nuclear surface and regulates nuclear migration in hypodermal precursor cells.


ensembl_gene_id: C10G8.5a.1
symbol: ncx-2
gene_biotype: protein_coding
description:
  Na_Ca_ex domain-containing protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.


ensembl_gene_id: C10G8.6.1
symbol: ceh-34
gene_biotype: protein_coding
description:
  Homeobox protein ceh-34; Acts as a transcription regulator. Binds to the cis-regulatory element of proapoptotic factor egl-1 gene and together with eya-1 activates egl-1 expression to promote motor neuron M4 sister cell apoptosis. Also promotes apoptosis of I1 pharyngeal neuron sister cell. Together with eya- 1, required to specify the coelomocyte fate in embryonic and postembryonic precursors. Belongs to the SIX/Sine oculis homeobox family.


ensembl_gene_id: C10H11.9.1
symbol: let-502
gene_biotype: protein_coding
description:
  Rho-associated protein kinase let-502; Negatively regulates mel-11 to relieve the inhibition of mlc- 4, allowing contraction of the circumferentially oriented microfilaments in epidermal cells and thereby regulating myosin II contractility during spermathecal contraction, cleavage furrow contraction in early embryos, and embryonic elongation and morphogenesis. Required for P-cell migration. May also play a role in oocyte cellularization.


ensembl_gene_id: C11G6.4a.1
symbol: nhr-28
gene_biotype: protein_coding
description:
  Nuclear hormone receptor family member nhr-28; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family.


ensembl_gene_id: C12C8.3a.1
symbol: lin-41
gene_biotype: protein_coding
description:
  Protein lin-41; Heterochronic protein which acts downstream of let-7 in temporal patterning. Plays a role in the developmental timing of postembryonic hypodermal seam cell division and fusion events and adult alae production. Represses lin-29 during late larval stages, which prevents terminal differentiation of hypodermal seam cells and promotes their division. Involved in post-transcriptional gene regulation, uses two independent pathways. Has direct and specific RNA-binding activity and, depending on the location (5'UTR or 3'UTR) of the target site, triggers either mRNA decay or repr [...]


ensembl_gene_id: C12D12.2a.1
symbol: glt-1
gene_biotype: protein_coding
description:
  Excitatory amino acid transporter; Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium (By similarity).


ensembl_gene_id: C12D8.10b.2
symbol: akt-1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase akt-1; Acts downstream of PI3 kinase age-1 and kinase pdk-1 in the daf-2/insulin receptor-like transduction pathway. Phosphorylates Forkhead-related daf-16 and the longevity-promoting skn-1 transcription factors, which inhibits their entry into the nucleus and antagonizes their functions. Has an essential role in regulating developmental arrest at the dauer stage. Plays a role in immune function and pathogen resistance. Regulates salt chemotaxis learning. Downstream of age-1 and together with akt-2 and sgk-1, promotes cell survival during embryonic devel [...]


ensembl_gene_id: C12D8.11.2
symbol: rop-1
gene_biotype: protein_coding
description:
  60 kDa SS-A/Ro ribonucleoprotein homolog; RNA-binding protein that binds to a single small cytoplasmic RNA molecule known as Y RNA. May stabilize this RNA from degradation; Belongs to the Ro 60 kDa family.


ensembl_gene_id: C12D8.5.1
symbol: daf-36
gene_biotype: protein_coding
description:
  Cholesterol 7-desaturase; Catalyzes the production of 7-dehydrocholesterol (7-DHC) by the desaturation of the C7-C8 single bond of cholesterol. This reaction is the first step in the synthesis of the steroid hormone Delta(7)- dafachronic acid. Dafachronic acids bind directly to the nuclear hormone receptor (NHR) daf-12, suppressing dauer formation and inducing reproductive growth.


ensembl_gene_id: C13B4.2.1
symbol: usp-14
gene_biotype: protein_coding
description:
  Ubiquitin carboxyl-terminal hydrolase 14; Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome (By similarity). Belongs to the peptidase C19 family. USP14/UBP6 subfamily.


ensembl_gene_id: C13B9.3.2
symbol: copd-1
gene_biotype: protein_coding
description:
  Probable coatomer subunit delta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity).


ensembl_gene_id: C13B9.4a.2
symbol: pdfr-1
gene_biotype: protein_coding
description:
  Calcitonin receptor-like protein 1; G-protein coupled receptor for PDF neuropeptides. Activated by peptides PDF-1 and PDF-2 but to a lesser extent with isoform c. Isoforms a and b are thought to act through the G-alpha(s) type of G proteins to elevate cAMP levels whereas isoform c inhibits cAMP levels through the G-alpha(i/o) type of G proteins. Involved in locomotion; more specifically mate searching behavior independent of nutritional status. Might have a role in touch sensitivity.


ensembl_gene_id: C13C12.1b.1
symbol: cal-1
gene_biotype: protein_coding
description:
  Calmodulin-like protein; This protein resembles calmodulin in sequence but possibly resembles troponin C in function.


ensembl_gene_id: C13C4.1.1
symbol: nhr-153
gene_biotype: protein_coding
description:
  Nuclear hormone receptor family member nhr-153; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family.


ensembl_gene_id: C13C4.2.1
symbol: nhr-154
gene_biotype: protein_coding
description:
  Nuclear hormone receptor family member nhr-154; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family.


ensembl_gene_id: C13C4.3a.1
symbol: nhr-136
gene_biotype: protein_coding
description:
  Nuclear hormone receptor family member nhr-136; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family.


ensembl_gene_id: C13D9.8.1
symbol: ncx-9
gene_biotype: protein_coding
description:
  Mitochondrial sodium/calcium exchanger protein; Mitochondrial sodium/calcium antiporter that mediates sodium- dependent calcium efflux from mitochondrion, thereby acting as a key regulator of mitochondrion calcium homeostasis (Probable). Required for patterning of neural circuits: functions in the same pathway as RAC- dependent effectors of the unc-6/netrin signaling pathway to set left/ right patterning of the VD/DD GABAergic circuit. Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.


ensembl_gene_id: C13G3.3c.1
symbol: pptr-2
gene_biotype: protein_coding
description:
  Serine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit.


ensembl_gene_id: C13G5.1.1
symbol: ceh-16
gene_biotype: protein_coding
description:
  Homeobox protein engrailed-like ceh-16; Required in the seam cells during embryonic development. Represses the fusion of the seam cells with the neighboring dorsal and ventral epidermal cells by repressing the expression of the fusion effector eff-1. Required for early seam cell differentiation. Triggers the expression of elt-5 and other seam cell markers and is indispensable for alae formation (a hallmark of seam cell differentiation). Required for the maintenance of correct boundaries between the lateral rows of seam cells and the ventral and dorsal row of epidermal cells during embr [...]


ensembl_gene_id: C14A4.1.1
symbol: dohh-1
gene_biotype: protein_coding
description:
  Deoxyhypusine hydroxylase; Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L- lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF- 5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function.


ensembl_gene_id: C14A4.11.1
symbol: ccm-3
gene_biotype: protein_coding
description:
  Programmed cell death protein 10 homolog; Involved in excretory canal elongation during postembryonic development. Plays a role in promoting Golgi stability, ER integrity and vesicle transport probably by regulating the activation of Rho GTPase cdc-42. Involved in fertility.


ensembl_gene_id: C14A4.3.1
symbol: C14A4.3
gene_biotype: protein_coding
description:
  Alpha-1,2-mannosyltransferase algn-9; Catalyzes the transfer of mannose from Dol-P-Man to lipid- linked oligosaccharides.


ensembl_gene_id: C14B1.4.2
symbol: wdr-5.1
gene_biotype: protein_coding
description:
  WD repeat-containing protein wdr-5.1; Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. Required for di- and trimethylation, particularly for the trimethylation at 'Lys-4' of histone H3. Not required for demethylation of histone H3 'Lys-27'. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, germline establishment, maintenance and function. Implicated in the epigenetic inheritance of lifespan over several generations. Acts in the germline to limit the longevity of the soma, pr [...]


ensembl_gene_id: C14B1.5.1
symbol: dph-1
gene_biotype: protein_coding
description:
  2-(3-amino-3-carboxypropyl)histidine synthase subunit 1; Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2.


ensembl_gene_id: C14B9.4b.1
symbol: plk-1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase plk-1; Required for oocyte nuclear envelope breakdown before entry of oocyte into spermatheca. In meiotic cells, required for spindle dynamics and probably for spindle attachment to the chromosomes. Zygotic role in the development of the germline and nerve cord. In mitotic cells, plays a role in spindle organization and centrosome maturation. Involved in asymmetric nuclear localization of cdc- 25.1 during embryogenesis which affects cell division timing. Together with plk- 2, regulates cytoplasm polarity in early embryos. May play a minor role in chromos [...]


ensembl_gene_id: C14B9.6a.3
symbol: gei-8
gene_biotype: protein_coding
description:
  Nuclear receptor corepressor 1; Mediates transcriptional repression by certain nuclear receptors. Plays a role in development and neuronal function. May play a role in muscle-specific oxidative mitochondrial metabolism.


ensembl_gene_id: C14B9.8b.1
symbol: C14B9.8
gene_biotype: protein_coding
description:
  Probable phosphorylase b kinase regulatory subunit alpha; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin (By similarity).


ensembl_gene_id: C14C10.6.1
symbol: erg-28
gene_biotype: protein_coding
description:
  Probable ergosterol biosynthetic protein 28 homolog; Promotes the translocation of slo-1 potassium ion channels from the endoplasmic reticulum to its final destination at the plasma membrane, probably by shielding from premature proteasomal degradation in the endoplasmic reticulum; Belongs to the ERG28 family.


ensembl_gene_id: C14F11.3.1
symbol: lite-1
gene_biotype: protein_coding
description:
  High-energy light unresponsive protein 1; Photoreceptor for short wavelength (UV) light that mediates UV-light-induced avoidance behavior. Directly senses and absorbs both UV-A and UV-B light with very high efficiency. Absorption of UV-B but not UV-A light shows resistance to photobleaching. In contrast to other photoreceptors, does not use a prosthetic chromophore to capture photons and only depends on its protein conformation.


ensembl_gene_id: C14F5.1a.1
symbol: dct-1
gene_biotype: protein_coding
description:
  NIP3 homolog; Initiates apoptosis in a BH3-independent mechanism possibly by recruiting ced-3 to mitochondria and other cytoplasmic membranes. Has a role in lifespan and tumor growth. Required for the induction of mitophagy under stress conditions. Belongs to the NIP3 family.


ensembl_gene_id: C14F5.2.1
symbol: zig-3
gene_biotype: protein_coding
description:
  Zwei Ig domain protein zig-3; Required for maintaining axon position of PVQ and PVP neurons postembryonically in the ventral nerve cord (VNC) by preventing axons drifting into the opposite side of the VNC that could occur during body growth and movement.


ensembl_gene_id: C14F5.5.1
symbol: sem-5
gene_biotype: protein_coding
description:
  Sex muscle abnormal protein 5; Adapter protein which modulates signaling mediated by several receptor tyrosine kinases such as egl-15 and let-23 probably acting upstream of let-60/ras. Negatively regulates vulva induction probably downstream of let-23. Involved in sex myoblast migration. Negatively regulates fluid homeostasis probably downstream of egl-15. During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles probably downstream of egl- 15. Involved in cytoskeleton dynamics and is recruited by mig-13 to the  [...]


ensembl_gene_id: C15A11.3.1
symbol: sol-1
gene_biotype: protein_coding
description:
  Suppressor of lurcher protein 1; Accessory protein required for glutamate-gated currents. May participate in the gating of non-NMDA (N-methyl-D-aspartate) ionotropic glutamate receptors such as glr-1.


ensembl_gene_id: C15A11.5.1
symbol: col-7
gene_biotype: protein_coding
description:
  Cuticle collagen 7; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.


ensembl_gene_id: C15B12.5b.1
symbol: gar-1
gene_biotype: protein_coding
description:
  Probable muscarinic acetylcholine receptor gar-1; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.


ensembl_gene_id: C15B12.6a.1
symbol: actl-1
gene_biotype: protein_coding
description:
  ACT1-like protein; May act as an adapter to facilitate downstream signaling for the receptor complex composed of ilcr-1 and ilcr-2, which is a signaling complex that modulates neuronal activity and animal behavior in response to sensory neuron input.


ensembl_gene_id: C15B12.7b.1
symbol: cdf-1
gene_biotype: protein_coding
description:
  Cation diffusion facilitator family protein 1; Involved in the regulation of Pn.p cell fate determination. Involved in zinc metabolism and the decrease of the cytosolic zinc concentration which is thought to modulate Ras signaling. Involved in zinc transport from the intestinal lumen to the pseudocoelum.


ensembl_gene_id: C15C6.4.1
symbol: C15C6.4
gene_biotype: protein_coding
description:
  Ribonuclease P protein subunit p29; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.


ensembl_gene_id: C15C7.1.1
symbol: syx-6
gene_biotype: protein_coding
description:
  Putative syntaxin 6; Potentially involved in docking of synaptic vesicles at presynaptic active zones; Belongs to the syntaxin family.


ensembl_gene_id: C15C7.7.1
symbol: C15C7.7
gene_biotype: protein_coding
description:
  GDP-fucose protein O-fucosyltransferase 1; Catalyzes the reaction that attaches fucose through an O- glycosidic linkage to a conserved serine or threonine residue in EGF domains; Belongs to the glycosyltransferase 65 family.


ensembl_gene_id: C15F1.3a.1
symbol: tra-2
gene_biotype: protein_coding
description:
  Sex-determining transformer protein 2; Plays a major role in controlling sexual cell fates. Promotes female development in XX animals where it sequesters one or more of the FEM proteins to the membrane thereby freeing the tra-1 protein (a putative transcription factor) to enter the nucleus and promote female development. In XO animals it acts as a receptor for her-1 which prevents it from binding to FEM proteins thereby repressing the activity of tra-1. Negatively regulates male development when bound to fem-3 and is required together with tra-1 for promoting spermatogenesis. Also requ [...]


ensembl_gene_id: C15F1.4.1
symbol: eif-2Bgamma
gene_biotype: protein_coding
description:
  Probable translation initiation factor eIF-2B subunit gamma; Catalyzes the exchange of eukaryotic initiation factor 2- bound GDP for GTP; Belongs to the eIF-2B gamma/epsilon subunits family.


ensembl_gene_id: C15F1.6.1
symbol: art-1
gene_biotype: protein_coding
description:
  Probable very-long-chain enoyl-CoA reductase art-1; Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precurso [...]


ensembl_gene_id: C15F1.7a.1
symbol: sod-1
gene_biotype: protein_coding
description:
  Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity). Required for normal brood size. May be involved in regulating mpk-1 phosphorylation downstream of phosphatase ptp-2 during oocyte maturation.


ensembl_gene_id: C15H11.3.1
symbol: nxf-1
gene_biotype: protein_coding
description:
  Nuclear RNA export factor 1; Involved in RNA export from the nucleus to the cytoplasm; Belongs to the NXF family.


ensembl_gene_id: C15H11.6.2
symbol: nxf-2
gene_biotype: protein_coding
description:
  Nuclear RNA export factor 2; May be involved in the export of cellular mRNA to the cytoplasm; Belongs to the NXF family.


ensembl_gene_id: C15H11.7.1
symbol: pas-1
gene_biotype: protein_coding
description:
  Proteasome subunit alpha type-6; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).


ensembl_gene_id: C15H11.8.2
symbol: rpoa-12
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.


ensembl_gene_id: C15H11.9.1
symbol: rrbs-1
gene_biotype: protein_coding
description:
  Ribosome biogenesis regulatory protein homolog; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family.


ensembl_gene_id: C15H9.6a.5
symbol: hsp-3
gene_biotype: protein_coding
description:
  Heat shock 70 kDa protein C; Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.


ensembl_gene_id: C15H9.7.1
symbol: kynu-1
gene_biotype: protein_coding
description:
  Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.


ensembl_gene_id: C16A11.1b.1
symbol: gpa-11
gene_biotype: protein_coding
description:
  Guanine nucleotide-binding protein alpha-11 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Mediates the transduction of food and serotonin signals, which modulates the avoidance response to the odorant octanol. Has a role in lifespan to promote longevity.


ensembl_gene_id: C16A3.10.2
symbol: oatr-1
gene_biotype: protein_coding
description:
  Probable ornithine aminotransferase, mitochondrial; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.


ensembl_gene_id: C16A3.1c.1
symbol: smrc-1
gene_biotype: protein_coding
description:
  SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1; ATP-dependent annealing helicase that catalyzes the rewinding of the stably unwound DNA.


ensembl_gene_id: C16A3.7.1
symbol: nfx-1
gene_biotype: protein_coding
description:
  Transcriptional repressor NF-X1 homolog; May play a role in transcription regulation; Belongs to the NFX1 family.


ensembl_gene_id: C16B8.1.2
symbol: lin-18
gene_biotype: protein_coding
description:
  Inactive tyrosine-protein kinase RYK; Has no detectable kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo (By similarity). Receptor which may act as a receptor for Wnt ligand mom-2. Plays a role in controlling P7.p vulva precursor cell lineage orientation during vulva development. Regulates pop-1 asymmetric distribution in P7.p and its daughter cells. Plays a role in the migration of ALM neurons during embryogenesis.


ensembl_gene_id: C16C10.10.1
symbol: glod-4
gene_biotype: protein_coding
description:
  Glyoxalase 1; Thought to act as a glyoxalase. May remove methylglyoxal from mitochondrial proteins. Has roles in reducing oxidative stress and increasing lifespan.


ensembl_gene_id: C16C10.12a.1
symbol: wht-3
gene_biotype: protein_coding
description:
  ABC transporter ATP-binding protein/permease wht-3; Required for efficient RNA interference (RNAi) of pop-1 indicating a role in the germline development. Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.


ensembl_gene_id: C16C10.2.1
symbol: C16C10.2
gene_biotype: protein_coding
description:
  Probable U3 small nucleolar RNA-associated protein 11; Involved in nucleolar processing of pre-18S ribosomal RNA.


ensembl_gene_id: C16C10.4.1
symbol: C16C10.4
gene_biotype: protein_coding
description:
  Probable histone deacetylase complex subunit SAP18; Acts in transcription repression. Involved in the tethering of the SIN3 complex to core histone proteins (By similarity). Belongs to the SAP18 family.


ensembl_gene_id: C16C10.5.1
symbol: rnf-121
gene_biotype: protein_coding
description:
  RING finger protein 121; Required for the cessation of distal tip cell migration at the end of larval morphogenesis; Belongs to the RNF121 family.


ensembl_gene_id: C16C10.6.1
symbol: ccdc-55
gene_biotype: protein_coding
description:
  Nuclear speckle splicing regulatory protein 1 homolog; Required for the cessation of distal tip cell migration at the end of larval morphogenesis; Belongs to the NSRP1 family.


ensembl_gene_id: C16C10.7a.1
symbol: rnf-5
gene_biotype: protein_coding
description:
  E3 ubiquitin ligase rnf-5; E3 ubiquitin ligase that plays a role in the maintenance of muscle cell boundaries and muscle dense bodies, which establish the adhesion sites of the muscle cells to the extracellular matrix. Ubiquitinates the LIM domain protein unc-95, thereby regulating its dislocalization from muscle dense bodies and weakening the link between the muscle cells and the hypodermis. Regulation of unc-95 dissociation from muscle dense bodies by ubiquitination plays an important role in ecdysis during molting. Plays a role in the cessation of distal tip cell migration at the en [...]


ensembl_gene_id: C17A2.8.1
symbol: nhr-72
gene_biotype: protein_coding
description:
  Nuclear hormone receptor family member nhr-75; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family.


ensembl_gene_id: C17C3.8.1
symbol: hlh-26
gene_biotype: protein_coding
description:
  Helix-loop-helix protein 26; Binds DNA via the E-box sequence 5'-CACGTG-3'. Binds DNA as a homodimer. Represses lag-2 transcription during embryogenesis via Notch signaling, in an unc-37-dependent manner. Also represses tbx-37 independent of Notch signaling.


ensembl_gene_id: C17D12.6a.1
symbol: spe-9
gene_biotype: protein_coding
description:
  Sperm transmembrane protein 9; Required for fertilization. May be required for cell adhesion and/or function as a signaling molecule.


ensembl_gene_id: C17E4.9a.1
symbol: nkb-1
gene_biotype: protein_coding
description:
  Sodium/potassium-transporting ATPase subunit beta-1; Non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane (By similarity). May also may function in the peptidic vesicle transport pathway from the endoplasmic reticulum for the defecation behaviors.


ensembl_gene_id: C17E7.8b.1
symbol: nhr-124
gene_biotype: protein_coding
description:
  Nuclear hormone receptor family member nhr-124; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family.


ensembl_gene_id: C17F4.6c.1
symbol: gcy-19
gene_biotype: protein_coding
description:
  Receptor-type guanylate cyclase gcy-19; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity).


ensembl_gene_id: C17G1.6a.1
symbol: nas-37
gene_biotype: protein_coding
description:
  Zinc metalloproteinase nas-37; Metalloprotease (By similarity). Plays an essential role in molting, a process during larval stages in which a new cuticle is formed and the old cuticle is shed. Required during ecdysis, the opening of the cuticle to allow the worm to escape.


ensembl_gene_id: C17G1.7.1
symbol: cysl-1
gene_biotype: protein_coding
description:
  Cysteine synthase 1; Catalyzes the formation of cysteine and acetate from O- acetylserine and hydrogen sulfide. By metabolizing hydrogen sulfide produced by cysl-2-mediated cyanide assimilation, mediates resistance to P.aeruginosa infection. Mediates survival in high levels of hydrogen sulfide. By sequestering egl-9, which in turn promotes hif-1- mediated transcription, regulates behavioral responses to hypoxia ; Belongs to the cysteine synthase/cystathionine beta- synthase family.


ensembl_gene_id: C17G1.8.2
symbol: tsp-21
gene_biotype: protein_coding
description:
  Tetraspanin-21; Regulates cell fate specification in the postembryonic mesodermal M lineage and body size, probably by positively modulating BMP-like Sma/Mab signaling at the ligand-receptor level. Promotes ventral fate specification in the M lineage, probably by positively modulating lin-12/Notch signaling; Belongs to the tetraspanin (TM4SF) family.


ensembl_gene_id: C17G10.4h.1
symbol: cdc-14
gene_biotype: protein_coding
description:
  Tyrosine-protein phosphatase cdc-14; Protein phosphatase that negatively regulates the G1-to-S phase transition to inhibit the cell cycle and establish quiescence in cells of multiple lineages including vulval, hypodermal and intestinal. Promotes nuclear accumulation and activity of the cyclin-dependent kinase inhibitor cki-1 which leads to inhibition of G1 progression during vulval tissue development. Has been shown to not be required for cytokinesis. However, in the embryo, in a contrasting study, has been shown to act as a regulator of central spindle formation and cytokinesis, and  [...]


ensembl_gene_id: C17G10.9e.1
symbol: eif-3.L
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 3 subunit L; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.


ensembl_gene_id: C18A11.5c.1
symbol: xol-1
gene_biotype: protein_coding
description:
  XO lethal protein 1; Acts as a primary sex-determining factor that promotes sexual differentiation. Absolutely required for proper sexual differentiation and male viability. High expression during gastrulation triggers male development, while low expression at that time triggers hermaphrodite development. Although related to GHMP kinase, its mode of action remains unclear; Belongs to the GHMP kinase family. Xol-1 subfamily.


ensembl_gene_id: C18A11.7a.1
symbol: dim-1
gene_biotype: protein_coding
description:
  Disorganized muscle protein 1; Stabilizes the attachment of the myofilament lattice to the muscle cell membrane. Isoform b is sufficient for wild-type function.


ensembl_gene_id: C18A3.1.1
symbol: damt-1
gene_biotype: protein_coding
description:
  DNA N6-methyl methyltransferase; Methylates DNA on the 6th position of adenine (N(6)- methyladenosine). N(6)-methyladenosine (m6A) DNA is involved in epigenetic transgenerational inheritance. Belongs to the MT-A70-like family.


ensembl_gene_id: C18A3.6a.1
symbol: rab-3
gene_biotype: protein_coding
description:
  Ras-related protein Rab-3; Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal (By similarity). Plays a role in the recruitment of endophilin unc-57 to synaptic vesicles. Probably by controlling dense-core vesicle trafficking, plays a role in the AVG neuron-mediated formation of the right axon tract of the ventral nerve cord. Belongs to the small GTPase superfamily. Rab family.


ensembl_gene_id: C18B12.3.1
symbol: dsc-1
gene_biotype: protein_coding
description:
  Homeobox protein dsc-1; Transcriptional regulator which plays a role in the expulsion step of defecation by controlling enteric muscle-specific expression of exp-1 which is required for enteric muscle contraction. Not required for exp-1 expression in the PDA neuron. Also involved in controlling the length of the defecation cycle.


ensembl_gene_id: C18C4.10b.1
symbol: klc-2
gene_biotype: protein_coding
description:
  Kinesin light chain; Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport (Probable). The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (Probable). Recruits unc-83 (within the unc-83-unc-84 LINC complex) to the nuclear envelope during nuclear migration to mediate the link between the nuclear envelope and the microtubule cytoskeleton in hypodermal precursor cells.


ensembl_gene_id: C18C4.9.1
symbol: glb-6
gene_biotype: protein_coding
description:
  Globin-like protein 6; May play a role as physiological sensor for oxygen via redox signaling and/or electron transport.


ensembl_gene_id: C18E3.8.1
symbol: hop-1
gene_biotype: protein_coding
description:
  Presenilin hop-1; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1). Probably works redundantly of lin-12, which provides more presenilin function.


ensembl_gene_id: C18E9.10b.1
symbol: sftd-3
gene_biotype: protein_coding
description:
  Vesicle transport protein; May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex. Belongs to the SFT2 family.


ensembl_gene_id: C18E9.11b.1
symbol: ooc-5
gene_biotype: protein_coding
description:
  Torsin-like protein; May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins; Belongs to the ClpA/ClpB family. Torsin subfamily.


ensembl_gene_id: C18E9.3d.1
symbol: szy-20
gene_biotype: protein_coding
description:
  Suppressor of zyg-1 protein 20; RNA binding protein that is required for normal cell division and cytokinesis during embryonic development. Functions with RNA-binding protein atx-2 to ensure embryonic cell division, and to this end, plays a role in the regulation of centrosome assembly, position and size, and in astral microtubule outgrowth and nucleation. Furthermore, negatively regulates the levels of the protein kinase zyg-1 at the centrosome. Also involved in ensuring centrosome attachment to the nuclear envelope.


ensembl_gene_id: C18E9.6.1
symbol: tomm-40
gene_biotype: protein_coding
description:
  Mitochondrial import receptor subunit TOM40 homolog; Channel-forming protein essential for import of protein precursors into mitochondria. Specifically required for nnt-1 accumulation in the mitochondria and may be involved in the secretion of daf-28/insulin from the mitochondria. Required for embryonic and larval development.


ensembl_gene_id: C18G1.2a.1
symbol: elt-7
gene_biotype: protein_coding
description:
  Transcription factor elt-7; Transcriptional activator that binds to the consensus sequence 5'-[AT]GATA[AG]-3'. Required for gut- specific differentiation, specifically acting with the GATA region- binding transcription factor elt-2 to control normal gene expression and promote normal formation of the intestine. May have a protective role in response to infection by Gram-negative bacteria such as P.aeruginosa.


ensembl_gene_id: C18G1.4a.1
symbol: pgl-3
gene_biotype: protein_coding
description:
  Guanyl-specific ribonuclease pgl-3; Guanyl-specific endoribonuclease which cleaves the phosphodiester bond in single-stranded RNA between the 3'-guanylic residue and the 5'-OH residue of adjacent nucleotide, resulting in the formation of a corresponding 2',3'-cyclic phosphate intermediate. P-granule component involved in germline development. Together with the P-granule component pgl-1, is involved in the formation of P-granules. Together with pgl- 1, probably recruits other granule components such as pos-1, mex-3 and glh-1, and RNA to P-granules. In vitro, binds mRNA; this interaction [...]


ensembl_gene_id: C18G1.5.1
symbol: hil-4
gene_biotype: protein_coding
description:
  Histone H1.4; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.


ensembl_gene_id: C18H9.7.1
symbol: rpy-1
gene_biotype: protein_coding
description:
  43 kDa receptor-associated protein of the synapse homolog; Postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction.


ensembl_gene_id: C23G10.4b.1
symbol: rpn-2
gene_biotype: protein_coding
description:
  26S proteasome non-ATPase regulatory subunit 1; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.


ensembl_gene_id: C23G10.7b.1
symbol: C23G10.7
gene_biotype: protein_coding
description:
  Probable tRNA (uracil-O(2)-)-methyltransferase; Probable adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase; Belongs to the TRM44 family.


ensembl_gene_id: C23H3.4a.2
symbol: sptl-1
gene_biotype: protein_coding
description:
  Serine palmitoyltransferase 1; Component of the serine palmitoyltransferase (SPT) that catalyzes the first committed step in sphingolipid biosynthesis, which is the condensation of an acyl-CoA species and L-serine. The catalytic core is composed of a heterodimer of sptl-1 and sptl-2 or sptl-1 and sptl-3 (By similarity). Required for the specification of abicobasal polarity and development of the gut lumen.


ensembl_gene_id: C24A3.6.1
symbol: twk-18
gene_biotype: protein_coding
description:
  TWiK family of potassium channels protein 18; Outwardly rectifying potassium channel protein; activity is sharply augmented by increase in temperature. Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.


ensembl_gene_id: C24B5.2c.1
symbol: spas-1
gene_biotype: protein_coding
description:
  Probable spastin homolog spas-1; Severs microtubules, probably in an ATP-dependent fashion. Belongs to the AAA ATPase family. Spastin subfamily.


ensembl_gene_id: C24F3.4a.1
symbol: qns-1
gene_biotype: protein_coding
description:
  Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family.


ensembl_gene_id: C24G6.13a.1
symbol: C24G6.13
gene_biotype: protein_coding
description:
  Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial; Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Belongs to the COX16 family.


ensembl_gene_id: C24G6.8.1
symbol: cox-16
gene_biotype: protein_coding
description:
  Probable peptidyl-tRNA hydrolase 2; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis; Belongs to the PTH2 family.


ensembl_gene_id: C24G7.1.1
symbol: delm-2
gene_biotype: protein_coding
description:
  DEgenerin Linked to Mechanosensation; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.


ensembl_gene_id: C24H11.9.1
symbol: mdt-21
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).


ensembl_gene_id: C25A1.10a.2
symbol: dao-5
gene_biotype: protein_coding
description:
  Nucleolar protein dao-5; Nucleolar protein which binds to RNA polymerase I and rDNA and is required for efficient RNA polymerase I-mediated rDNA transcription. Maintains the epigenetically active status of rDNA chromatin which facilitates rDNA transcription and sustains germline development, ensuring fertility. Plays a role in the modulation of nucleolus size. May play a role in the regulation of lifespan. Belongs to the NOLC1 family.


ensembl_gene_id: C25A1.11a.1
symbol: aha-1
gene_biotype: protein_coding
description:
  Aryl hydrocarbon receptor nuclear translocator homolog; Has a role in cellular differentiation. Required for pharyngeal development. In collaboration with ahr-1 it is involved in RMEL/R and SDQR neuron cell migration. Acts in the cellular response to hypoxia. Involved in aggregation behavior by regulating soluble guanylate cyclase gene expression in the URX neurons.


ensembl_gene_id: C25A1.12b.2
symbol: lid-1
gene_biotype: protein_coding
description:
  Abhydrolase domain-containing protein lid-1; Acts coordinately with atgl-1 within the lipolytic cascade to distribute stored energy to tissues during nutritional deprivation. Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.


ensembl_gene_id: C25A1.3.1
symbol: tag-72
gene_biotype: protein_coding
description:
  mRNA cap guanine-N7 methyltransferase; mRNA-capping methyltransferase that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Binds RNA containing 5'-terminal GpppC (By similarity); Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.


ensembl_gene_id: C25A1.5.1
symbol: fath-1
gene_biotype: protein_coding
description:
  Fatty acid 2-hydroxylase; Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...]


ensembl_gene_id: C25A1.6.1
symbol: nola-3
gene_biotype: protein_coding
description:
  Putative H/ACA ribonucleoprotein complex subunit 3; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity).


ensembl_gene_id: C25A1.9a.1
symbol: rsa-1
gene_biotype: protein_coding
description:
  Serine/threonine-protein phosphatase 2A regulatory subunit rsa-1; Regulatory subunit of phosphatase let-92 which recruits let- 92/paa-1 complex to the centrosomes, thereby regulating microtubule outgrowth from centrosomes and mitotic spindle assembly ensuring the stability of kinetochore microtubules.


ensembl_gene_id: C25A11.4f.1
symbol: ajm-1
gene_biotype: protein_coding
description:
  Apical junction molecule; Controls adherens junction integrity. Required for the correct rate and completion of elongation of the embryos.


ensembl_gene_id: C25D7.3.1
symbol: sdc-3
gene_biotype: protein_coding
description:
  Zinc finger protein sdc-3; Component of the SDC complex that functions in sex determination and in X chromosome dosage compensation specifically in hermaphrodite (XX) animals. Plays a central role in the recruitment of the condensin I-like dosage compensation complex to the male sex-determining autosomal gene her-1, thereby contributing to its repression and initiating hermaphrodite sexual development. Involved in the recruitment and assembly of the dosage compensation complex and the dosage compensation protein dpy-21 onto the X chromosomes in hermaphrodites, which leads to a reductio [...]


ensembl_gene_id: C25D7.8.2
symbol: otub-1
gene_biotype: protein_coding
description:
  Ubiquitin thioesterase otubain-like; Hydrolase that can remove conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation. Specifically cleaves 'Lys-48'-linked polyubiquitin.


ensembl_gene_id: C25E10.9.1
symbol: swm-1
gene_biotype: protein_coding
description:
  Serine protease inhibitor swm-1; Serine protease inhibitor (Probable). Probably by inhibiting serine protease tyr-5 in males, prevents the maturation of spermatids into mature motile spermatozoa until their transfer into a hermaphrodite. Also required for efficient sperm transfer and thus for male fertility.


ensembl_gene_id: C25F6.2a.1
symbol: dlg-1
gene_biotype: protein_coding
description:
  Disks large homolog 1; Essential multidomain scaffolding protein required for normal development (Probable). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells (By similarity). Required for proper embryonic elongation. Acts upstream of ajm-1 and becomes localized to apical junctions independently of ajm-1. With let-413, cooperatively regulates ajm-1 localization to apical junctions. Belongs to the MAGUK family.


ensembl_gene_id: C25F6.3.1
symbol: dpyd-1
gene_biotype: protein_coding
description:
  Dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine (By similarity). Involved in the degradation of the chemotherapeutic drug 5-fluorouracil.


ensembl_gene_id: C25F6.4.1
symbol: ddr-1
gene_biotype: protein_coding
description:
  Discoidin domain-containing receptor A; Receptor which, together with svh-4, is involved in axon guidance to establish the tracts for the ventral and dorsal nerve cords during nervous system development. May play a role in axon regeneration following injury in D-type motor neurons ; Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.


ensembl_gene_id: C25G4.5.1
symbol: dpy-26
gene_biotype: protein_coding
description:
  Condensin complex subunit dpy-26; Required for both chromosome condensation and segregation and for X-chromosome dosage compensation depending on its binding partners. Member of the condensin I complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes and for proper chromosome segregation in mitosis and meiosis. As a member of the condensin I complex, further controls the crossover number and distribution in meiosis by restricting double strand break formation, probably by influencing higher-order chromosome structure. Plays a role in rob [...]


ensembl_gene_id: C25G6.5.1
symbol: npr-11
gene_biotype: protein_coding
description:
  Putative neuropeptide Y receptor 11; Could be a receptor for neuropeptide Y and peptide YY; Belongs to the G-protein coupled receptor 1 family.


ensembl_gene_id: C25H3.12.1
symbol: ift-43
gene_biotype: protein_coding
description:
  Intraflagellar transport protein 43 homolog; As a component of IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein- coupled receptors (GPCRs), it is involved in ciliogenesis (Probable). In particular, may act redundantly with the intraflagellar transport protein ift-139 to regulate the transport of specific ciliary cargo proteins such as che-3 which are related to motility.


ensembl_gene_id: C25H3.5.1
symbol: flp-27
gene_biotype: protein_coding
description:
  FMRFamide-like neuropeptides 27; FMRFamides and FMRFamide-like peptides are neuropeptides. Belongs to the FARP (FMRFamide related peptide) family.


ensembl_gene_id: C26B2.6.1
symbol: elpc-4
gene_biotype: protein_coding
description:
  Putative elongator complex protein 4; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs; Belongs to the ELP4 family.


ensembl_gene_id: C26C6.2.1
symbol: goa-1
gene_biotype: protein_coding
description:
  Guanine nucleotide-binding protein G(o) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. In the 1-cell embryo, probably together with gpa-16, controls nuclear rotation and spindle elongation during mitosis. During the first embryonic cell divisions, plays a role in gpr-1/2 cortical localization and in the proper orientation of EMS blastomere mitotic spindle. Polarity determinants (par genes) may regulate lin- 5/gpr-1/gpr-2/goa-1 locally to create  [...]


ensembl_gene_id: C26C6.3.1
symbol: nas-36
gene_biotype: protein_coding
description:
  Zinc metalloproteinase nas-36; Metalloprotease (By similarity). Involved in molting, a process during larval stages in which a new cuticle is formed and the old cuticle is shed.


ensembl_gene_id: C26D10.1.1
symbol: ran-3
gene_biotype: protein_coding
description:
  Regulator of chromosome condensation; Key component of the Ran GTPase system, which comprises ran- 1, ran-2 and ran-3 and is essential in nucleocytoplasmic transport. Promotes the exchange of Ran-bound GDP by GTP and regulates the onset of chromosome condensation in the S phase. Binds to the chromatin. RCC1 (ran-3)/RAN (ran-1) complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA.


ensembl_gene_id: C26D10.2a.1
symbol: hel-1
gene_biotype: protein_coding
description:
  Spliceosome RNA helicase DDX39B homolog; Required for mRNA export out of the nucleus. May play a role in spliceosome assembly.


ensembl_gene_id: C26E6.4.1
symbol: rpb-2
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerase II subunit RPB2; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB2 is  [...]


ensembl_gene_id: C26E6.5.1
symbol: fsn-1
gene_biotype: protein_coding
description:
  F-box/SPRY domain-containing protein 1; Component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which is required for the restriction and/or maturation of synapses in GABAergic neuromuscular junction (NMJ) presynaptic neurons. Promotes NRJ synapse development and synaptic transmission by negatively regulating the daf- 2/InsR pathway in muscles. By targeting convertase egl-3 for degradation, negatively modulates insulin-like protein ins-4 and ins-6 processing. May stabilize synapse formation by promoting the down-regulation of scd-2. Regulates axon termination in PLM an [...]


ensembl_gene_id: C26E6.8b.1
symbol: ula-1
gene_biotype: protein_coding
description:
  NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric uba-3-ula-1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-rfl-1 (uba-3) thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of ubc-12. Required for rfl-1 (uba-3) nuclear localization during early embryonic development. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.


ensembl_gene_id: C26E6.9c.1
symbol: set-2
gene_biotype: protein_coding
description:
  Histone-lysine N-methyltransferase set-2; Histone methyltransferase that specifically di- and trimethylates 'Lys-4' of histone H3 at all developmental stages and in adult germ cells. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Implicated in the epigenetic inheritance of lifespan over several generations. Acts in the germline to limit the longevity of the soma, probably by regulating a lipid metabolism pathway that signals from the germline to the intestine, thereby preventing accumulation of mono-unsaturated fatty acids. Methylation in th [...]


ensembl_gene_id: C26G2.1b.1
symbol: syg-2
gene_biotype: protein_coding
description:
  Synaptogenesis protein syg-2; Cell adhesion protein. Determines synapse formation. Required for correct localization of syg-1 at synaptic sites.


ensembl_gene_id: C27A12.5.1
symbol: ceh-2
gene_biotype: protein_coding
description:
  Homeobox protein ceh-2; Required for activity of the M3 pharyngeal motor neuron. Belongs to the EMX homeobox family.


ensembl_gene_id: C27A2.1.1
symbol: smc-5
gene_biotype: protein_coding
description:
  Structural maintenance of chromosomes protein 5; Core component of the smc-5/smc-6 complex. Functions in DNA double strand break repair by promoting sister- chromatid homologous recombination during meiosis. Acts in a DNA repair pathway for removal of ionizing radiation- and ultraviolet (UV) radiation-induced DNA lesions that is distinct from classical nucleotide excision repair and the translesion synthesis pathway. Also involved in the recovery of stalled replication forks. Belongs to the SMC family. SMC5 subfamily.


ensembl_gene_id: C27A2.3.2
symbol: ify-1
gene_biotype: protein_coding
description:
  Securin-like protein; Acts as a chaperone and as an inhibitor for separase sep-1. Plays an essential role in maintaining chromosome cohesion prior to meiotic and mitotic anaphase, in cytokinesis and in organizing the spindle and the centrosome. Ubiquitination-dependent degradation at the onset of anaphase is likely to activate sep-1 resulting in the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. Also required for cortical granule exocytosis.


ensembl_gene_id: C27B7.1b.1
symbol: spr-2
gene_biotype: protein_coding
description:
  Suppressor of presenilin-2; Potential corepressor protein, which may affect chromatin structure and/or transcription. May participate in the transcriptional repression of the presenilin protein hop-1. Belongs to the nucleosome assembly protein (NAP) family.


ensembl_gene_id: C27B7.8.1
symbol: rap-1
gene_biotype: protein_coding
description:
  Ras-related protein Rap-1; Required in the hypodermis for proper formation of the cuticle; Belongs to the small GTPase superfamily. Ras family.


ensembl_gene_id: C27C12.7.2
symbol: dpf-2
gene_biotype: protein_coding
description:
  Dipeptidyl peptidase family member 2; Removes N-terminal dipeptides sequentially from polypeptides (By similarity). Essential for control of distal tip cell migration. Belongs to the peptidase S9B family. DPPIV subfamily.


ensembl_gene_id: C27D11.1.1
symbol: egl-45
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 3 subunit A; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.


ensembl_gene_id: C27D6.6.1
symbol: srb-5
gene_biotype: protein_coding
description:
  Serpentine receptor class beta-5; G-protein coupled receptor (Probable). Plays a role in the navigational capacity of sperm and promotes the targeting of sperm derived from males to the fertilization site in the uterus of hermaphrodites.


ensembl_gene_id: C27F2.5.1
symbol: vps-22
gene_biotype: protein_coding
description:
  Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family.


ensembl_gene_id: C27H5.5c.1
symbol: col-36
gene_biotype: protein_coding
description:
  Cuticle collagen 36; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.


ensembl_gene_id: C27H5.7a.1
symbol: dyf-13
gene_biotype: protein_coding
description:
  Intraflagellar transport protein 56 homolog; Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. May be required for ciliary entrance and transport of specific ciliary cargo proteins such as che-3 which are related to motility.


ensembl_gene_id: C27H6.1a.1
symbol: unc-41
gene_biotype: protein_coding
description:
  Putative stoned B-like protein; Potential adapter protein, which may be involved in endocytic vesicle recycling of synaptic vesicles; Belongs to the Stoned B family.


ensembl_gene_id: C27H6.2.1
symbol: ruvb-1
gene_biotype: protein_coding
description:
  RuvB-like 1; Possesses single-stranded DNA-stimulated ATPase and ATP dependent DNA helicase (3' to 5') activity suggesting a role in nuclear processes such as recombination and transcription (By similarity). May participate in several chromatin remodeling complexes that mediate the ATP-dependent exchange of histones and remodel chromatin by shifting nucleosomes (By similarity). Involvement in these complexes is likely required for transcriptional activation of selected genes and DNA repair in response to DNA damage (By similarity). Involved in the Ce- Tor signaling pathway whereby it i [...]


ensembl_gene_id: C27H6.9.1
symbol: C27H6.9
gene_biotype: protein_coding
description:
  Mitochondrial genome maintenance exonuclease 1; Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance; Belongs to the MGME1 family.


ensembl_gene_id: C28A5.4b.1
symbol: ceh-43
gene_biotype: protein_coding
description:
  Homeobox protein ceh-43; Required for development of the anterior hypdermis during embryonic morphogenesis for cell adhesion; also affects embryonic and larval viability.


ensembl_gene_id: C28D4.1.1
symbol: nhr-100
gene_biotype: protein_coding
description:
  Nuclear hormone receptor family member nhr-100; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family.


ensembl_gene_id: C28G1.3.1
symbol: sec-15
gene_biotype: protein_coding
description:
  Exocyst complex component 6; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC15 family.


ensembl_gene_id: C28H8.1.1
symbol: bcl-7
gene_biotype: protein_coding
description:
  BCL7-like protein; Required for the terminal differentiation of seam cells, and the differentiation of distal tip cells important for normal somatic gonad and germ cell development. Plays a role in the Wnt signaling pathway, regulating the expression of beta-catenin homologs wrm-1, bar- 1 and sys-1, and the localization of wrm-1 and the wnt signaling pathway component pop-1 during asymmetric cell division of seam cells and the Z-cell lineage of the somatic gonad, respectively. May have a pro-apoptotic role, possibly linked to the negative regulation of expression of anti-apoptotic fact [...]


ensembl_gene_id: C28H8.11a.2
symbol: tdo-2
gene_biotype: protein_coding
description:
  Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. Involved in regulation of protein homeostasis, longevity and reproducive life span. Specifically regulates proteotoxicity due to age-related aggregation of proteins like alpha- synuclein, via its effects on tryptophan metabolism.


ensembl_gene_id: C28H8.12.1
symbol: dnc-2
gene_biotype: protein_coding
description:
  Probable dynactin subunit 2; Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. May play a role in synapse formation during brain development (By similarity); Belongs to the dynactin subunit 2 family.


ensembl_gene_id: C28H8.4.1
symbol: C28H8.4
gene_biotype: protein_coding
description:
  ER lumen protein-retaining receptor erd-2.2; Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi (By similarity); Belongs to the ERD2 family.


ensembl_gene_id: C28H8.6a.1
symbol: pxl-1
gene_biotype: protein_coding
description:
  Paxillin homolog 1; Required for myofilament organization of the pharyngeal sarcomeres and for pharyngeal muscle contractions and hence for pharyngeal pumping. Together with lin-8, might be required for myofilament organization in the body wall muscles ; Belongs to the paxillin family.


ensembl_gene_id: C29A12.3a.1
symbol: lig-1
gene_biotype: protein_coding
description:
  DNA ligase 1; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.


ensembl_gene_id: C29E4.1.1
symbol: col-90
gene_biotype: protein_coding
description:
  Putative cuticle collagen 90; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment (By similarity).


ensembl_gene_id: C29E4.10.1
symbol: C29E4.10
gene_biotype: protein_coding
description:
  Putative galactocerebrosidase; Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Belongs to the glycosyl hydrolase 59 family.


ensembl_gene_id: C29E4.2.1
symbol: kle-2
gene_biotype: protein_coding
description:
  Condensin-2 complex subunit kle-2; Regulatory subunit of the condensin II complex, a complex that seems to play a role in prophase chromosome condensation and in chromosome segregation in mitosis and in meiosis.


ensembl_gene_id: C29E4.3a.1
symbol: ran-2
gene_biotype: protein_coding
description:
  Ran GTPase-activating protein 2; GTPase system comprising ran-1, ran-2 and ran-3 is essential in nucleocytoplasmic trafficking. Ran-2 is a GTPase activator for the nuclear RAS-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state. Required for correct chromosome alignment and segregation on the metaphase plate.


ensembl_gene_id: C29E4.4.1
symbol: npp-15
gene_biotype: protein_coding
description:
  Nuclear pore complex protein 15; Important for early nematode development. Belongs to the nucleoporin Nup133 family.


ensembl_gene_id: C29E4.7.1
symbol: gsto-1
gene_biotype: protein_coding
description:
  Glutathione transferase omega-1; Exhibits glutathione-dependent thiol transferase activity (By similarity). Has dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid (By similarity). Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) (By similarity). Protects against environmental stress and oxidative stress ; Belongs to the GST superfamily. Omega family.


ensembl_gene_id: C29E4.8.2
symbol: let-754
gene_biotype: protein_coding
description:
  Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.


ensembl_gene_id: C29E6.1a.2
symbol: let-653
gene_biotype: protein_coding
description:
  Protein let-653; Required for epithelial tube development and shaping. Involved in the morphogenesis and function of the three unicellular tubes of the excretory system, the canal cell, the duct cell and the pore cell. Also plays a role in cuticle development, alae formation and shaping of the vulval lumen. Required for larval development.


ensembl_gene_id: C29E6.2a.1
symbol: trpa-1
gene_biotype: protein_coding
description:
  Transient receptor potential cation channel subfamily A member 1 homolog; Receptor-activated non-selective cation channel involved in the nose-touch response and foraging behavior. Contributes to the neural responses of sensory neurons to touch, particularly after repeated mechanical stimulation. Has no apparent role in thermosensory or chemosensory behaviors.


ensembl_gene_id: C29F3.2.1
symbol: wrt-8
gene_biotype: protein_coding
description:
  Warthog protein 8 C-product; Intercellular signal essential for a variety of patterning events during development.


ensembl_gene_id: C29F7.3.1
symbol: C29F7.3
gene_biotype: protein_coding
description:
  UMP-CMP kinase 1; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.


ensembl_gene_id: C29F9.7.1
symbol: pat-4
gene_biotype: protein_coding
description:
  Integrin-linked protein kinase homolog pat-4; Probable pseudokinase that acts as an adapter protein. Component of an integrin containing attachment complex, which is required for muscle development and maintenance. Involved in the assembly of dense bodies and M lines during body wall muscle development by recruiting several of their components including integrin pat-3, cpna-1, unc-89 and unc- 112 to integrin-mediated attachment sites. Plays a role in distal tip cell (DTC) migration and in oocyte development probably by regulating the actin cytoskeleton. During the formation of neuromus [...]


ensembl_gene_id: C29H12.3a.1
symbol: rgs-3
gene_biotype: protein_coding
description:
  Regulator of G-protein signaling rgs-3; Modulates chemotaxis responses by regulating positively the sensitivity to CO2 levels in BAG neurons and by regulating negatively the sensitivity to quinine in ASH sensory neurons.


ensembl_gene_id: C30A5.2.1
symbol: rfs-1
gene_biotype: protein_coding
description:
  RAD51-like protein 1; Has a role in the homologous recombination repair (HRR) of genomic DNA during meiosis. Required for rad-51 recruitment onto ssDNA gaps generated at stalled replication fork barriers.


ensembl_gene_id: C30A5.3.1
symbol: mob-4
gene_biotype: protein_coding
description:
  MOB-like protein phocein; May play a role in membrane trafficking, specifically in membrane budding reactions; Belongs to the MOB1/phocein family.


ensembl_gene_id: C30A5.7b.1
symbol: unc-86
gene_biotype: protein_coding
description:
  Transcription factor unc-86; Transcription factor required for correct cell fate determination and differentiation in diverse neuronal cell lineages where it plays a role in specifying the fate of daughter cells during cell divisions. Involved in sensory neuron production and function. Binds both alone and with mec-3 to the mec-3 promoter to initiate and maintain mec-3 expression which is required for sensory neuron differentiation. In addition, binds both alone and with mec-3 to the promoters of mec-4 and mec-7 which act to regulate sensory neuron function. Involved in determining the [...]


ensembl_gene_id: C30B5.3.1
symbol: cpb-2
gene_biotype: protein_coding
description:
  Cytoplasmic polyadenylation element-binding protein 2; Cytoplasmic polyadenylation element binding protein that binds to and regulates the translation of specific mRNAs (By similarity). Not required for oogenesis.


ensembl_gene_id: C30B5.5.1
symbol: daf-37
gene_biotype: protein_coding
description:
  G-protein coupled receptor daf-37; G-protein coupled receptor (GPCR) that forms a heterodimer with daf-38 to control dauer formation and behavior. Receptor for the ascaroside pheromone ascr#2. Required for the response to dauer inducing pheromones, specifically the ascaroside ascr#2. May serve neuronal specific roles in response to ascr#2 with expression in ASI neurons controlling dauer formation in larvae, and expression in ASK neurons playing a role in longevity and hermaphrodite repulsion. May function upstream of the daf-11, daf-7 and daf-2 signaling pathways.


ensembl_gene_id: C30C11.2.1
symbol: rpn-3
gene_biotype: protein_coding
description:
  26S proteasome non-ATPase regulatory subunit 3; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.


ensembl_gene_id: C30D11.1j.1
symbol: unc-103
gene_biotype: protein_coding
description:
  Potassium voltage-gated channel unc-103; Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly (By similarity). Regulates the movements of the male's copulatory spicules before and during male mating behavior ; Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv11.1/KCNH2 sub-subfamily.


ensembl_gene_id: C30F12.1.1
symbol: rege-1
gene_biotype: protein_coding
description:
  Endoribonuclease rege-1; Endonuclease which binds to the 3'UTR of target mRNAs and induces degradation of the transcript. Negatively regulates the expression of the transcription factor ets-4, which probably controls the expression of lipid metabolism genes. May play a role in the clearance of apoptotic cell corpses.


ensembl_gene_id: C30F8.2.1
symbol: vha-16
gene_biotype: protein_coding
description:
  V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family.


ensembl_gene_id: C30F8.4a.1
symbol: kin-32
gene_biotype: protein_coding
description:
  Inactive tyrosine-protein kinase kin-32; Has apparently no tyrosine kinase activity in vitro when expressed in mammalian cells; Belongs to the protein kinase superfamily. Tyr protein kinase family. FAK subfamily.


ensembl_gene_id: C30G4.3.1
symbol: gcy-11
gene_biotype: protein_coding
description:
  Receptor-type guanylate cyclase gcy-11; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity).


ensembl_gene_id: C32A3.1a.1
symbol: sel-8
gene_biotype: protein_coding
description:
  Protein lag-3; glp-1 and lin-12 promote signaling by recruiting lag-3 to target promoters, where it functions as a transcriptional activator. May regulate phosphatase lip-1 mRNA transcription downstream of glp-1.


ensembl_gene_id: C32A3.2.1
symbol: mrps-31
gene_biotype: protein_coding
description:
  28S ribosomal protein S31, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mS31 family.


ensembl_gene_id: C32D5.2.1
symbol: sma-6
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase sma-6; Involved in TGF-beta pathway. May be a receptor for daf-7; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.


ensembl_gene_id: C32D5.5.1
symbol: set-4
gene_biotype: protein_coding
description:
  Histone-lysine N-methyltransferase Suv4-20; Histone methyltransferase that specifically di- and trimethylates 'Lys-20' of histone H4 (H4K20me2/me3). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression (By similarity). Contributes to dosage compensation of X chromosome-relative to autosome-linked gene expression, possibly by converting H4K20me1 to H4K20m2/me3 on autosomes. Involved in the regulation of growth and body fat metabolism downstream of the TOR complex 2 pathway.


ensembl_gene_id: C32D5.9.1
symbol: lgg-1
gene_biotype: protein_coding
description:
  Protein lgg-1; Ubiquitin-like modifier involved in the formation of autophagosomal vacuoles (autophagosomes). When lipidated mediates tethering between adjacent membranes and stimulates membrane fusion during autophagy. Recruits lipidated-lgg-2 to maturing autophagosomes. Acts in the aggrephagy pathway, which is the macroautophagic degradation of ubiquitinated protein aggregates, and preferentially interacts with autophagy proteins and substrates containing LIR motifs to mediate autophagosome formation and protein aggregate degradation. In particular, binds to components of the unc-51- [...]


ensembl_gene_id: C32E12.2.1
symbol: pde-5
gene_biotype: protein_coding
description:
  Probable 3',5'-cyclic phosphodiesterase pde-5; Redundantly with pde-1, plays a role in the AFD thermosensory neurons to regulate microvilli receptive ending morphology, possibly by regulating cGMP levels.


ensembl_gene_id: C32E12.5.2
symbol: sem-2
gene_biotype: protein_coding
description:
  Transcription factor sem-2; Probable transcription factor required for embryogenesis, vulval development and cell fate specification of the postembryonic mesoderm (also known as the M lineage). Specifically, required for the specification of sex myoblast cells and their development into the muscles that are necessary for egg-laying. In addition, may be involved in RME GABAergic motor neuron progenitor cell fate specification.


ensembl_gene_id: C32E8.10c.1
symbol: unc-11
gene_biotype: protein_coding
description:
  Phosphatidylinositol-binding clathrin assembly protein unc-11; Assembly protein recruiting clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. May be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. Involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. Required for the efficient targeting of the synaptic vesicle protein synaptobrevin. Belongs to the PICALM/SNAP91 family.


ensembl_gene_id: C32E8.11.1
symbol: ubr-1
gene_biotype: protein_coding
description:
  E3 ubiquitin-protein ligase ubr-1; E3 ubiquitin-protein ligase which is a component of the N-end rule pathway (By similarity). Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N- end rule, leading to their ubiquitination and subsequent degradation (By similarity). In complex with ced-3, required for the ced-3-mediated cleavage and subsequent degradation of the heterochronic protein lin-28 to regulate seam cell fate patterning during larval development. Negatively regulates glutamate metabolism through the aspartate aminotrans [...]


ensembl_gene_id: C32E8.7.1
symbol: ric-19
gene_biotype: protein_coding
description:
  Resistance to inhibitors of cholinesterase protein 19; May be involved in a role in neurotransmitter secretion.


ensembl_gene_id: C32F10.2.1
symbol: lin-35
gene_biotype: protein_coding
description:
  Retinoblastoma-like protein homolog lin-35; Key regulator of cell division which acts as a transcriptional repressor and negatively regulates cell cycle progression in its active unphosphorylated form, but allows cell cycle progression when phosphorylated. When unphosphorylated and in its active form, interacts with E2F transcription factors such as efl-1 to repress their transcriptional activity and negatively regulate the progression through the G1 phase of the cell cycle during postembryonic development. May furthermore act with cell cycle regulator cki-1 to negatively regulate cell [...]


ensembl_gene_id: C32F10.5.1
symbol: hmg-3
gene_biotype: protein_coding
description:
  FACT complex subunit ssrp1-B; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment [...]


ensembl_gene_id: C32F10.6.1
symbol: nhr-2
gene_biotype: protein_coding
description:
  Nuclear hormone receptor family member nhr-2; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family.


ensembl_gene_id: C33A11.1.1
symbol: nfki-1
gene_biotype: protein_coding
description:
  ANK repeat-containing protein nipk-1; Acts downstream of the receptor complex composed of ilcr-1 and ilcr-2, which is a signaling complex that modulates neuronal activity and animal behavior in response to sensory neuron input. Mediates signaling of the complex; Belongs to the iASPP family.


ensembl_gene_id: C33A12.1.1
symbol: C33A12.1
gene_biotype: protein_coding
description:
  Probable NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).


ensembl_gene_id: C33B4.3c.1
symbol: shn-1
gene_biotype: protein_coding
description:
  Protein shank; Scaffold protein that most likely acts in the postsynaptic density (PSD) of excitatory synapses which orchestrates synapse formation and maintenance at neuromuscular junctions. Associates with and trafficks the L-type calcium channel egl-19 to the cell surface of body wall muscles to ensure the function of the calcium channel and therefore maintain the Ca(2+) current density. The maintenance of Ca(2+) also allows for the downstream regulation of Ca(2+)-induced expression of genes such as gem-4. Plays a role in the regulation of the defecation cycle, and this may be in as [...]


ensembl_gene_id: C33D12.2a.1
symbol: cnnm-3
gene_biotype: protein_coding
description:
  Metal transporter cnnm-3; Probable metal transporter. Probably acts redundantly with the other metal transport proteins cnnm-1, cnnm-2, cnnm-4 and cnnm-5 to regulate Mg(2+) homeostasis. Promotes postembryonic gonad development by regulating Mg(2+) levels, probably via AMPK signaling.


ensembl_gene_id: C33D12.6.1
symbol: rsef-1
gene_biotype: protein_coding
description:
  Ras and EF-hand domain-containing protein homolog; Binds GTP and GDP (By similarity). Plays a role in uterine seam cell development.


ensembl_gene_id: C33D12.7.1
symbol: ceh-30
gene_biotype: protein_coding
description:
  Homeobox protein ceh-30; Cell-type specific anti-apoptotic transcription factor required for the sexually dimorphic survival of the male-specific CEM (cephalic male) sensory neurons during sex determination. In hermaphrodites, the homologous cells undergo programmed cell death due to transcriptional repression of ceh-30 by tra-1, the terminal regulator in the sex determination pathway.


ensembl_gene_id: C33D3.1.1
symbol: elt-2
gene_biotype: protein_coding
description:
  Transcription factor elt-2; Transcriptional activator that binds to the consensus sequence 5'-[AT]GATA[AG]-3'. Predominantly directs the transcription of intestinal genes such as ges-1, cpr-6, pho-1, ftn-1 and lev-11, and itself. Required for gut-specific differentiation, specifically acting with the GATA region-binding transcription factor elt-7 to control normal gene expression and promote normal formation of the intestine. Regulates intestinal gene expression in response to hypoxia to promote longevity. Regulates tissue specific gene expression at basal levels and in response to bac [...]


ensembl_gene_id: C33F10.5d.1
symbol: rig-6
gene_biotype: protein_coding
description:
  Contactin rig-6; Probable cell adhesion protein involved in patterning of the nervous system, playing a role in ALM and PLM touch receptor axon growth and VNC axon navigation. By associating with the transmembrane protein sax-7, mediates axonal interactions to establish synaptic connections between the AVG interneuron and the two PHC sensory neurons. Also required for non-neuronal cell migration in the excretory canal, regulating excretory canal elongation and excretory cell morphogenesis. Plays a role in regulating male mating behavior.


ensembl_gene_id: C33F10.9.1
symbol: msp-40
gene_biotype: protein_coding
description:
  Major sperm protein 19/31/40/45/50/51/53/59/61/65/81/113/142; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.


ensembl_gene_id: C33G3.1b.1
symbol: dyc-1
gene_biotype: protein_coding
description:
  Dystrophin-like protein 1; Together with dys-1 and hlh-1, participates in a common muscular function.


ensembl_gene_id: C33G8.6.1
symbol: nhr-42
gene_biotype: protein_coding
description:
  Nuclear hormone receptor family member nhr-42; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family.


ensembl_gene_id: C33H5.12a.1
symbol: rsp-6
gene_biotype: protein_coding
description:
  Probable splicing factor, arginine/serine-rich 6; Plays a functionally redundant role in shifting germ cell sexual differentiation in hermaprodites. Required for the development of somatic gonad structures and for progression from larval stage to adulthood; Belongs to the splicing factor SR family.


ensembl_gene_id: C33H5.15b.1
symbol: sgo-1
gene_biotype: protein_coding
description:
  Shugoshin; Component of cell cycle checkpoints, which ensures chromosome segregation during meiosis and mitosis. During meiotic prophase, it is involved in the regulation of the synapsis checkpoint, which monitors whether homologous chromosomes have synapsed, and the DNA damage response. Plays a central role in chromosome cohesion during cell division by preventing premature dissociation of cohesin complex after prophase, when most of cohesin complex dissociates from chromosomes arms (By similarity). Belongs to the shugoshin family.


ensembl_gene_id: C33H5.18b.2
symbol: cdgs-1
gene_biotype: protein_coding
description:
  Phosphatidate cytidylyltransferase; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol (PtdIns); Belongs to the CDS family.


ensembl_gene_id: C33H5.9.1
symbol: sec-10
gene_biotype: protein_coding
description:
  Exocyst complex component 5; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC10 family.


ensembl_gene_id: C34B2.10.1
symbol: C34B2.10
gene_biotype: protein_coding
description:
  Probable signal peptidase complex subunit 1; Microsomal signal peptidase is a membrane-bound endoproteinase that removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.


ensembl_gene_id: C34B2.6.1
symbol: lonp-1
gene_biotype: protein_coding
description:
  Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner. Involved in the degradation of transcription factor atfs-1 in the mi [...]


ensembl_gene_id: C34B2.7.1
symbol: sdha-2
gene_biotype: protein_coding
description:
  Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).


ensembl_gene_id: C34B7.3.1
symbol: cyp-36A1
gene_biotype: protein_coding
description:
  Probable cytochrome P450 CYP36A1; Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.


ensembl_gene_id: C34C12.3.1
symbol: pph-6
gene_biotype: protein_coding
description:
  Serine/threonine-protein phosphatase 6 catalytic subunit; Catalytic subunit of protein phosphatase 6 (PP6) (By similarity). In complex with saps-1, promotes actomyosin contractility during cytokinesis by regulating the organization of cortical non- muscle myosin II nmy-2 and thus contributing to correct spindle positioning. Also required for the proper generation of pulling forces on spindle poles during anaphase by regulating the cortical localization of gpr-1, gpr-2 and lin-5. Belongs to the PPP phosphatase family. PP-6 (PP-V) subfamily.


ensembl_gene_id: C34C12.8.1
symbol: C34C12.8
gene_biotype: protein_coding
description:
  GrpE protein homolog, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins (By similarity).


ensembl_gene_id: C34C6.5a.1
symbol: sphk-1
gene_biotype: protein_coding
description:
  Sphingosine kinase 1; Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on sphinganine (By similarity). Required for neurotransmitter release from neuromuscular junctions. Acts by recruiting the synaptic vesicle priming protein unc-13 to synapses  (Probable).


ensembl_gene_id: C34D1.3.1
symbol: odr-3
gene_biotype: protein_coding
description:
  Guanine nucleotide-binding protein alpha-17 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. This specific G-alpha subunit plays an important role in olfaction and in cilia morphogenesis. Involved in chemotactic responses to attractants diacetyl, pyrazine, 2,4,5-trimethylthiazole, benzaldehyde, isoamyl alcohol, butanone and 2,3-pentanedione. Displays a redundant function with gpa-3 in chemotactic responses. Involved in avoidance responses to copper, sodium dodecyl sulfate and linoleic acid. I [...]


ensembl_gene_id: C34D4.12a.1
symbol: cyn-12
gene_biotype: protein_coding
description:
  Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.


ensembl_gene_id: C34D4.13.1
symbol: mutd-1
gene_biotype: protein_coding
description:
  Biogenesis of lysosome-related organelles complex 1 subunit 5; Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in gut granule biogenesis; Belongs to the BLOC1S5 family.


ensembl_gene_id: C34D4.14f.1
symbol: hecd-1
gene_biotype: protein_coding
description:
  E3 ubiquitin-protein ligase hecd-1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity). Involved in the ubiquitination and proteasomal-mediated degradation of cytoplasmic and mitochondrial proteins. Positively regulates lin-12 activity in the anchor cell (AC)/vulval precursor (VU) cell fate decision. Negatively regulates glp-1 activity in germline proliferation. May play a role in the formation of fibrous organelles, a hemidesmosome-like s [...]


ensembl_gene_id: C34E10.1.1
symbol: gop-3
gene_biotype: protein_coding
description:
  SAM50-like protein gop-3; May play a role in the maintenance of the structure of mitochondrial cristae; Belongs to the SAM50/omp85 family.


ensembl_gene_id: C34E10.2.1
symbol: gop-2
gene_biotype: protein_coding
description:
  GPN-loop GTPase 1; Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family.


ensembl_gene_id: C34E10.4b.1
symbol: prx-10
gene_biotype: protein_coding
description:
  Tryptophan--tRNA ligase, mitochondrial; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family.


ensembl_gene_id: C34E10.5.2
symbol: prmt-5
gene_biotype: protein_coding
description:
  Protein arginine N-methyltransferase 5; Catalyzes the symmetrical dimethylation of arginine residues in targets such as small nuclear ribonucleoproteins, histone H2A/H4 and cbp-1. Dimethylation occurs in a distributive manner where the protein is released after the addition of the first methyl group prior to rebinding for the addition of the second methyl group. Plays a role in the negative regulation of DNA damage-induced apoptosis. By methylating cbp-1, may prevent apoptosis by repressing the capacity of cbp-1 to enhance cep-1 dependent transcription activation of the programmed cell [...]


ensembl_gene_id: C34E10.6.1
symbol: atp-2
gene_biotype: protein_coding
description:
  ATP synthase subunit beta, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the c [...]


ensembl_gene_id: C34E10.7.1
symbol: cnd-1
gene_biotype: protein_coding
description:
  Neurogenic differentiation factor 1; Acts as a transcriptional regulator whose activity is required for several aspects of motor neuron fate specification, including cell division patterns, proper spatiotemporal expression of fate-specific markers, and normal axonal morphology and pathfinding.


ensembl_gene_id: C34E10.8.1
symbol: sumv-1
gene_biotype: protein_coding
description:
  Protein sumv-1; Nuclear factor that influences the activity of genes involved in vulval development.


ensembl_gene_id: C34F11.3d.1
symbol: ampd-1
gene_biotype: protein_coding
description:
  AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.


ensembl_gene_id: C34F11.6.1
symbol: msp-49
gene_biotype: protein_coding
description:
  Major sperm protein 49; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.


ensembl_gene_id: C34F6.4.1
symbol: hst-2
gene_biotype: protein_coding
description:
  Heparan sulfate 2-O-sulfotransferase hst-2; Catalyzes the transfer of sulfate to the C2-position of selected hexuronic acid residues within the maturing heparan sulfate (HS). Involved in cell adhesion and guidance by specifically modifying proteoglycans in the extracellular matrix and on the cell surface that are essential for axon migrations.


ensembl_gene_id: C34F6.8.3
symbol: idh-2
gene_biotype: protein_coding
description:
  Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family.


ensembl_gene_id: C34G6.7a.1
symbol: stam-1
gene_biotype: protein_coding
description:
  Signal transducing adapter molecule 1; Binds, sorts and targets the polycystin complex (lov-1 and pkd-2) for lysosomal degradation, acting on early endosomes located at the ciliary base. Functions in the germline together with the ephrin receptor (vab-1) signaling pathway to negatively regulate MAPK activation. May have a role as a positive regulator of meiotic maturation in oocytes, acting independently of vab-1.


ensembl_gene_id: C34H3.2.1
symbol: odd-2
gene_biotype: protein_coding
description:
  Protein odd-skipped-related 2; May function as transcription regulator (Probable). Required for morphogenesis and function of the digestive tract. Belongs to the Odd C2H2-type zinc-finger protein family.


ensembl_gene_id: C35A11.4.1
symbol: C35A11.4
gene_biotype: protein_coding
description:
  MFS domain-containing protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.


ensembl_gene_id: C35B1.1.1
symbol: ubc-1
gene_biotype: protein_coding
description:
  Ubiquitin-conjugating enzyme E2 1; Catalyzes the covalent attachment of ubiquitin to other proteins; Belongs to the ubiquitin-conjugating enzyme family.


ensembl_gene_id: C35B8.2b.1
symbol: vav-1
gene_biotype: protein_coding
description:
  Protein vav-1; Acts as guanine nucleotide exchange factor (GEF) for Rho GTPase. Has a critical roles in the generation of rhythmic behaviors: feeding, defecation and ovulation by dynamically regulating the concentration of intracellular calcium. Plays a role in male tail tip morphogenesis.


ensembl_gene_id: C35C5.1.2
symbol: sdc-2
gene_biotype: protein_coding
description:
  Sex determination and dosage compensation protein sdc-2; Component of the SDC complex that functions in sex determination and in X chromosome dosage compensation specifically in hermaphrodite (XX) animals. Required for the recruitment of the condensin I-like dosage compensation complex to the male sex-determining autosomal gene her-1, thereby contributing to its repression and initiating hermaphrodite sexual development. Plays a central role in X-chromosome recognition and in the recruitment and assembly of the dosage compensation complex and the dosage compensation protein dpy-21 onto [...]


ensembl_gene_id: C35C5.3b.1
symbol: selt-1.1
gene_biotype: protein_coding
description:
  Thioredoxin reductase-like selenoprotein T homolog selt-1.1; Probably has thioredoxin reductase-like oxidoreductase activity. Plays a role in regulating the oxidative stress response, and odorant and pathogenic bacteria avoidance behavior.


ensembl_gene_id: C35D10.16.1
symbol: arx-6
gene_biotype: protein_coding
description:
  Probable actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament (By similarity).


ensembl_gene_id: C35D10.17.1
symbol: C35D10.17
gene_biotype: protein_coding
description:
  COX assembly mitochondrial protein 2 homolog; May be involved in cytochrome c oxidase biogenesis. Belongs to the CMC family.


ensembl_gene_id: C35D10.4.1
symbol: coq-8
gene_biotype: protein_coding
description:
  Atypical kinase coq-8, mitochondrial; Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. Its substrate specificity is unclear: either acts as protein kinase that phosphorylates other proteins in the CoQ complex to stabilize their interactions or acts as a small molecule kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway.


ensembl_gene_id: C35D10.9b.2
symbol: ced-4
gene_biotype: protein_coding
description:
  Cell death protein 4; Component of the egl-1, ced-9, ced-4 and ced-3 apoptotic signaling cascade required for the initiation of programmed cell death in cells fated to die during embryonic and postembryonic development. During oogenesis, required for germline apoptosis downstream of ced-9 and upstream of ced-3 but independently of egl-1. May regulate germline apoptosis in response to DNA damage, probably downstream of let-60/ras and mpk-1 pathway. Regulates CEP neuron apoptosis in response to high Al(3+) levels. During male tail morphogenesis, promotes apoptosis of the tail-spike cell  [...]


ensembl_gene_id: C36A4.8a.1
symbol: brc-1
gene_biotype: protein_coding
description:
  Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of polyubiquitin chains and plays a central role in DNA repair. Plays a role in triggering cellular responses at damage sites in response to DNA damage that may be induced by UV and ionizing radiation for example. Functions in double-strand break repair, and is required for homologous recombination between sister chromatids in meiotic and mitotic cells. In particular, protects against chromosome non-disjunction and nuclear fragmentation during meiotic double-strand  [...]


ensembl_gene_id: C36B1.4.2
symbol: pas-4
gene_biotype: protein_coding
description:
  Proteasome subunit alpha type-7; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.


ensembl_gene_id: C36B1.7.1
symbol: dhfr-1
gene_biotype: protein_coding
description:
  Putative dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).


ensembl_gene_id: C36B1.8b.1
symbol: gls-1
gene_biotype: protein_coding
description:
  Germline survival defective-1; Required maternally for germline survival by forming a maternal complex with gld-3. During hermaphrodite development forms a complex with gld-3 which promotes the sperm/oocyte switch freeing the translational repressor fbf to turn off sperm promoting factors. Required for proper oocyte differentiation and oogenic meiotic arrest. Stimulates the enzymatic activity of gld-4 and together they prevent gld-1 mRNA degradation.


ensembl_gene_id: C36E8.5.4
symbol: tbb-2
gene_biotype: protein_coding
description:
  Tubulin beta-2 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain; Belongs to the tubulin family.


ensembl_gene_id: C36H8.3.1
symbol: flp-9
gene_biotype: protein_coding
description:
  FMRFamide-like neuropeptides 9; FMRFamides and FMRFamide-like peptides are neuropeptides. Belongs to the FARP (FMRFamide related peptide) family.


ensembl_gene_id: C37A2.4a.1
symbol: cye-1
gene_biotype: protein_coding
description:
  G1/S-specific cyclin-E; Essential for the control of the cell cycle at the G1/S (start) transition. In association with cdk-2, regulates proliferation, quiescent state and cell fate during the development of several cell lineages. In the embryo, initiates the establishment of cell polarity through the recruitment of the centrosomal proteins spd-2 and spd-5 during prophase. During the development of the vulva, controls the onset of vulval cell terminal differentiation by controlling the duration of G1 phase. During hypoderm development at early larval stages, controls syncytial fate of  [...]


ensembl_gene_id: C37A2.6.1
symbol: C37A2.6
gene_biotype: protein_coding
description:
  Electron transfer flavoprotein beta subunit lysine methyltransferase homolog; Probable methyltransferase.


ensembl_gene_id: C37A2.7.1
symbol: C37A2.7
gene_biotype: protein_coding
description:
  60S acidic ribosomal protein P2; Plays an important role in the elongation step of protein synthesis.


ensembl_gene_id: C37A5.9.1
symbol: pry-1
gene_biotype: protein_coding
description:
  Axin-like protein pry-1; Works in parallel with axl-1 in negatively regulating bar-1 signaling in vulval precursor cells and Q neuroblasts. Inhibits Wnt signaling, which affects tissue specific expression of Hox genes, egl- 5, lin-39 and mab-5. This in turn affects QR (postembryonic neuroblast) cell migration, vulval cell fate specification, and the development of sensory structures by the seam cell lineage. Has a role in alae V cell patterning, ray formation in the male tail and axon guidance. Does not affect B cell polarity.


ensembl_gene_id: C37C3.2.1
symbol: C37C3.2
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 5; Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]).


ensembl_gene_id: C37C3.6b.1
symbol: mig-6
gene_biotype: protein_coding
description:
  Papilin; Involved in pharynx morphogenesis probably by remodeling the basement membrane. [Isoform b]: Plays a role in post embryonic distal cell tip migration. Essential extracellular matrix (ECM) protein required for hypodermal enclosure in the embryo.


ensembl_gene_id: C37C3.8c.1
symbol: memo-1
gene_biotype: protein_coding
description:
  Protein memo-1 homolog; Plays a role in the oxidative stress response and the maintenance of longevity by regulating the interaction between GTPase rho-1 and oxidase bli-3. In turn, this serves to modulate bli-3 activity and the control of reactive oxygen species production. May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton (By similarity); Belongs to the MEMO1 family.


ensembl_gene_id: C37E2.1.2
symbol: idhb-1
gene_biotype: protein_coding
description:
  Probable isocitrate dehydrogenase [NAD] subunit beta, mitochondrial; Belongs to the isocitrate and isopropylmalate dehydrogenases family.


ensembl_gene_id: C37E2.4.1
symbol: ceh-36
gene_biotype: protein_coding
description:
  Homeobox protein ceh-36; Mediates chemosensory function of ASE and AWC neurons. In ASE neurons, required to diversify the fate of the ASEL neurons from the ASER neurons. In cooperation with the transcription factor sox-2, required for the differentiation of AWC olfactory neurons. May regulate the expression of sox-2 in AWC olfactory neurons. Belongs to the paired homeobox family.


ensembl_gene_id: C37E2.5a.1
symbol: ceh-37
gene_biotype: protein_coding
description:
  Homeobox protein ceh-37; Binds to the telomeric DNA sequence 5'-TTAGGC-3', requiring at least 1.5 repeats for binding. Bends telomeric DNA and may provide chromosome stability. Also required for development of AWB olfactory neurons; Belongs to the paired homeobox family.


ensembl_gene_id: C37H5.2.1
symbol: abhd-5.1
gene_biotype: protein_coding
description:
  Abhydrolase domain-containing protein abhd-5.1; Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.


ensembl_gene_id: C37H5.3a.1
symbol: abhd-5.2
gene_biotype: protein_coding
description:
  Abhydrolase domain-containing protein abhd-5.2; Acts coordinately with phospholipase atgl-1 within the lipolytic cascade to distribute stored energy to tissues to maintain energy levels during the dauer phase. Localizes atgl-1 to lipid droplets, possibly to facilitate triglyceride hydrolysis. Regulates lipid droplet size, lipid content, the exchange of lipids between lipid droplets and fusion of lipid droplets during the dauer phase. Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.


ensembl_gene_id: C37H5.6a.1
symbol: adss-1
gene_biotype: protein_coding
description:
  Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.


ensembl_gene_id: C38C10.1.1
symbol: tkr-1
gene_biotype: protein_coding
description:
  Probable G-protein coupled receptor tkr-1; Not known. Putative receptor; Belongs to the G-protein coupled receptor 1 family.


ensembl_gene_id: C38C10.4.1
symbol: gpr-2
gene_biotype: protein_coding
description:
  G-protein regulator 2; In the 1-cell embryo, probably together with gpr-1, controls nuclear rotation and spindle elongation during mitosis. Complex of gpr-1 and gpr-2, in association with lin- 5, activates G-protein signaling to affect mitotic spindle force. Polarity determinants (par genes) may regulate lin- 5/gpr-1/gpr-2/goa-1 locally to create the asymmetric forces that drive spindle movement.


ensembl_gene_id: C38C10.5b.1
symbol: rgr-1
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required [...]


ensembl_gene_id: C38C3.5.1
symbol: unc-60
gene_biotype: protein_coding
description:
  Actin-depolymerizing factor 2, isoform c; Depolymerizes growing actin filaments in muscle cells; required for the assembly of actin filaments into the functional contractile myofilament lattice of muscle. Belongs to the actin-binding proteins ADF family.


ensembl_gene_id: C38D4.3.1
symbol: mel-28
gene_biotype: protein_coding
description:
  Protein mel-28; Nuclear envelope protein which has essential roles in assembly of nuclear pore complexes and in chromatin maintenance during the cell cycle. Appears to be a stable structural component of the nuclear envelope during interphase. In dividing cells, localizes to kinetochores during early stages of mitosis and then to chromatin during late mitosis. Important for several mitotic processes including chromosome condensation, kinetochore assembly, chromosome segregation and cell-cycle timing. In postmitotic cells, plays a role in the early steps of nuclear pore complex assembly [...]


ensembl_gene_id: C38D4.6a.1
symbol: pal-1
gene_biotype: protein_coding
description:
  Homeobox protein pal-1; Transcriptional activator. Interacts with promoter regions for tbx-8.9, tbx-9, elt-1, hnd-1, scrt-1, and vab-7 genes. Binds the sequence ATTTATGAC. Binds to the enhancer region of the hlh-1 gene promoter during embryonic body wall muscle development. Activates the gene for mab-5 in embryo development. Necessary for vab-7 expression in C blastomeres in the posterior of embryos. Required for posterior V6 neuroectoblast cell fate specification during postembryonic neurogenesis (patterning) which generates the characteristic ray lineage during male tail development. [...]


ensembl_gene_id: C38H2.2.2
symbol: C38H2.2
gene_biotype: protein_coding
description:
  Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1; Glycosyltransferase that generates the core 1 O-glycan Gal- beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins.


ensembl_gene_id: C39B5.6.1
symbol: C39B5.6
gene_biotype: protein_coding
description:
  Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Belongs to the GatB/GatE family. GatB subfamily.


ensembl_gene_id: C39E9.14a.2
symbol: dli-1
gene_biotype: protein_coding
description:
  Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.


ensembl_gene_id: C40C9.5e.1
symbol: nlg-1
gene_biotype: protein_coding
description:
  Neuroligin-1; Probable neuronal cell surface protein thought to be involved in cell-cell-interactions by forming intercellular junctions through binding to beta-neurexins (By similarity). Plays a role in the clustering of the GABA(A) receptor unc-49 at postsynaptic sites in neuromuscular junctions (NMJs) via the interaction with madd-4 and neurexin nrx-1 and is thereby required for normal GABAergic synaptic transmission. Belongs to the type-B carboxylesterase/lipase family.


ensembl_gene_id: C40H1.1.1
symbol: cpb-1
gene_biotype: protein_coding
description:
  Cytoplasmic polyadenylation element-binding protein 1; Cytoplasmic polyadenylation element binding protein that binds to and regulates the translation of specific mRNAs. Essential for progression through meiosis. Involved in spermatogenesis.


ensembl_gene_id: C40H1.4.1
symbol: elo-4
gene_biotype: protein_coding
description:
  Putative fatty acid elongation protein 4; Could be implicated in synthesis of very long chain fatty acids; Belongs to the ELO family.


ensembl_gene_id: C40H1.6.1
symbol: ufc-1
gene_biotype: protein_coding
description:
  Ubiquitin-fold modifier-conjugating enzyme 1; E2-like enzyme which forms an intermediate with ufm-1. The intermediate is formed via a thioester linkage (By similarity).


ensembl_gene_id: C40H5.5a.1
symbol: ttx-3
gene_biotype: protein_coding
description:
  LIM/homeobox protein ttx-3; Required for specification of the AIA and AIY interneurons and the NSM neurons. Positively regulates the expression of a number of genes including ceh-23, kal-1, hen-1, ser-2, unc-17 and sra-11 in AIY interneurons and cat-4, flp-4, bas-1, ptps-1 and mgl-1 in NSM neurons. Also acts in an autoregulatory feedback loop to maintain its own expression. Plays a role in the thermotactic response, olfactory imprinting, regulation of longevity, control of dauer formation and axon outgrowth and pathfinding. Not required for normal chemosensory behavior.


ensembl_gene_id: C41C4.1.1
symbol: chst-1
gene_biotype: protein_coding
description:
  Carbohydrate sulfotransferase chst-1; Catalyzes the transfer of sulfate to position 4 of non- reducing N-acetylgalactosamine (GalNAc) residue of chondroitin.


ensembl_gene_id: C41C4.4a.1
symbol: ire-1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase/endoribonuclease ire-1; Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto- activation. The active endoribonuclease domain splices xbp-1 precursor mRNA to produce the mature form which then induces transcription of UPR target genes. Unfolded protein response (UPR) transcriptional activation by ire-1, as well as translational attenuation by pek-1 in a complementary pathway, maintains ER homeostasis. Regulates the transcriptional up-regulation of nucleoside-diphosphatase apy-1 upon ER str [...]


ensembl_gene_id: C41C4.5e.2
symbol: unc-105
gene_biotype: protein_coding
description:
  Degenerin-like protein unc-105; Ion channel which is permeable to small monovalent cations. Shown not to be H+-ion gated. May be mechanosensitive and is required for growth and muscle development; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.


ensembl_gene_id: C41C4.6.1
symbol: ulp-4
gene_biotype: protein_coding
description:
  Ubiquitin-like protease 4; Protease required for deconjugation of smo-1 conjugates from target proteins which is necessary for cell cycle progression. Required for respiration and the maintenance of normal mitochondrial homeostasis.


ensembl_gene_id: C41C4.7a.1
symbol: ctns-1
gene_biotype: protein_coding
description:
  Cystinosin homolog; Thought to transport cystine out of lysosomes (By similarity). May play a role in the degradation of engulfed apoptotic cells.


ensembl_gene_id: C41C4.8.2
symbol: cdc-48.2
gene_biotype: protein_coding
description:
  Transitional endoplasmic reticulum ATPase homolog 2; ATP-dependent chaperone which probably uses the energy provided by ATP hydrolysis to generate mechanical force to unfold substrate proteins, disassemble protein complexes, and disaggregate protein aggregates. However, able to prevent aggregation of unfolded proteins also in an ATP-independent manner. Targets polyubiquitinated proteins for proteasomal degradation by binding to 'Lys-48'-linked polyubiquitin chains. Involved in the cytoplasmic elimination of misfolded proteins exported from the ER. This pathway, known as ERAD, prevents  [...]


ensembl_gene_id: C41D11.2.1
symbol: eif-3.H
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 3 subunit H; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.


ensembl_gene_id: C41D11.8.1
symbol: cps-6
gene_biotype: protein_coding
description:
  Endonuclease G, mitochondrial; Endonuclease important for programmed cell death; it mediates apoptotic DNA fragmentation.


ensembl_gene_id: C41G6.5.1
symbol: nhr-164
gene_biotype: protein_coding
description:
  Nuclear hormone receptor family member nhr-164; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family.


ensembl_gene_id: C41G7.3.1
symbol: C41G7.3
gene_biotype: protein_coding
description:
  Messenger RNA-binding inhibitor of apoptosis 1; RNA-binding protein which binds to its own mRNA and target mRNAs to negatively regulate gene expression to modulate apoptosis and differentiation in the germline. Negatively regulates the expression of the argonaute protein wago-4, and may thus play a role in RNA-mediated gene silencing (RNAi) in the germline.


ensembl_gene_id: C41G7.5a.1
symbol: ahr-1
gene_biotype: protein_coding
description:
  Aryl hydrocarbon receptor protein 1; Probable ligand-activated transcriptional activator. Acts as a transcriptional regulator in GABAergic motor neuron cell fate specification and development. Promotes cell-type-specific expression of guanylate cyclase genes that have key roles in aggregation behavior and hyperoxia avoidance. Has no role in carbon dioxide avoidance.


ensembl_gene_id: C42C1.11a.1
symbol: ltah-1.1
gene_biotype: protein_coding
description:
  Aminopeptidase ltah-1.1; Aminopeptidase which preferentially removes N-terminal Arg and Lys residues from peptides and proteins.


ensembl_gene_id: C42C1.13b.1
symbol: C42C1.13
gene_biotype: protein_coding
description:
  Protein-lysine methyltransferase C42C1.13; Protein-lysine N-methyltransferase. Belongs to the methyltransferase superfamily. METTL21 family.


ensembl_gene_id: C42D4.8.1
symbol: rpc-1
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.


ensembl_gene_id: C42D8.2a.1
symbol: vit-2
gene_biotype: protein_coding
description:
  Vitellogenin-2; Precursor of the egg-yolk proteins that are sources of nutrients during embryonic development.


ensembl_gene_id: C42D8.4b.1
symbol: ets-5
gene_biotype: protein_coding
description:
  ETS domain-containing transcription factor ets-5; Transcription factor that plays a role in the differentiation and function of the CO(2)- and O(2)-sensing BAG neurons. The BAG neurons are required for the behavioral avoidance of environmental CO(2) and the sensing of decreased O(2) levels. Promotes the expression of genes that play a role in CO(2)- and O(2)-sensing and in egg-laying in the BAG neurons. Positively regulates the transcription of the receptor-type guanylate cyclase gcy-9, which is a critical component of the CO(2) transduction pathway, in the BAG neurons. May mediate tra [...]


ensembl_gene_id: C42D8.5a.2
symbol: acn-1
gene_biotype: protein_coding
description:
  Inactive angiotensin-converting enzyme-related protein; Inactive as a metallopeptidase, due to a lack of active site residues. Required for larval molting, male tail development, and formation of adult alae. Acts in the heterochronic pathway and plays a role in the developmental timing of postembryonic hypodermal seam cell division and adult alae production. Acts synergistically with apl-1 in let-7 regulated postembryonic cell division events. Might act downstream of the heterochronic protein lin-41. Negative regulator of lifespan, heat and oxidative stress response and age-related deg [...]


ensembl_gene_id: C42D8.8a.1
symbol: apl-1
gene_biotype: protein_coding
description:
  Amyloid-beta-like protein; Required for normal developmental progression throughout all life stages. Specifically required for the molt stage during all larval transitions and morphogenesis. Acts with heterochronic genes, including members of the let-7 family, to regulate larval stage to adult transition. Acts synergistically with acn-1 in let-7 regulated postembryonic cell division of hypodermal seam cells. Acts in multiple pathways to influence daf-12 and daf-16 activity to in turn regulate physiological and reproductive processes such as body size and egg- laying. May play a role in [...]


ensembl_gene_id: C43C3.1.2
symbol: ifp-1
gene_biotype: protein_coding
description:
  Intermediate filament protein ifp-1; Cytoplasmic intermediate filaments provide mechanical strength to cells. Not essential protein.


ensembl_gene_id: C43C3.2f.1
symbol: npr-18
gene_biotype: protein_coding
description:
  Neuropeptide receptor 18; Probable receptor for neuropeptide ligand nlp-9 that plays a role in octopamine signaling and specifically, the octapamine inhibition of aversion responses in olfactory sensory neurons. In AWB olfactory sensory neurons, required for the detection of preferred food sources. Belongs to the G-protein coupled receptor 1 family.


ensembl_gene_id: C43C3.3.1
symbol: dyf-7
gene_biotype: protein_coding
description:
  Protein dyf-7; Required for permeability of amphid and phasmid neurons to external dyes, chemotaxis to ammonium chloride, avoidance of high osmotic stimuli, male mating and dauer formation. Along with dex-1, enables neurite growth and maintenance by anchoring amphid dendritic tips during neuron cell body migration in embryonic and larval development.


ensembl_gene_id: C43E11.10.1
symbol: cdc-6
gene_biotype: protein_coding
description:
  Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.


ensembl_gene_id: C43E11.7.1
symbol: ndx-7
gene_biotype: protein_coding
description:
  Putative nudix hydrolase 7; Probably mediates the hydrolysis of some nucleoside diphosphate derivatives; Belongs to the Nudix hydrolase family.


ensembl_gene_id: C43E11.8.1
symbol: exoc-7
gene_biotype: protein_coding
description:
  Exocyst complex component 7; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.


ensembl_gene_id: C43E11.9.1
symbol: C43E11.9
gene_biotype: protein_coding
description:
  60S ribosome subunit biogenesis protein NIP7 homolog; Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly; Belongs to the NIP7 family.


ensembl_gene_id: C43G2.1c.1
symbol: paqr-1
gene_biotype: protein_coding
description:
  Progestin and adipoQ receptor-like protein 1; Probable receptor, which may be involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Belongs to the ADIPOR family.


ensembl_gene_id: C43G2.2a.1
symbol: bicd-1
gene_biotype: protein_coding
description:
  Protein bicaudal D homolog; Part of a complex with dlc-1 and egal-1, which is recruited to the nuclear envelope by unc-83, where in turn, it recruits dynein to the nuclear surface and regulates nuclear migration in hypodermal precursor cells  (Probable). Required for the formation of dendritic branches of PVD sensory neurons ; Belongs to the BicD family.


ensembl_gene_id: C43H8.1.1
symbol: arch-1
gene_biotype: protein_coding
description:
  Protein archease-like; Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RtcB (F16A11.2).


ensembl_gene_id: C43H8.2.2
symbol: mafr-1
gene_biotype: protein_coding
description:
  Repressor of RNA polymerase III transcription MAF1; Element of the TORC1 signaling pathway that acts as a mediator of diverse signals and that represses RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA. Belongs to the MAF1 family.


ensembl_gene_id: C44B11.3.1
symbol: mec-12
gene_biotype: protein_coding
description:
  Detyrosinated tubulin alpha-3 chain; Tubulin is the major constituent of microtubules (Probable). It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (Probable). Component of the large-diameter neuronal microtubules which contains 15 protofilaments. Plays a role in mechanosensory transduction (touch sensitivity).


ensembl_gene_id: C44B12.2a.1
symbol: ost-1
gene_biotype: protein_coding
description:
  SPARC; Has a high affinity for collagen. Affects nematode body morphology and mobility. Essential for C.elegans development and muscle function. The cysteine-rich region could have protease inhibitory activity or may provide the framework for a protein binding module. Probable role in skeletal morphogenesis; Belongs to the SPARC family.


ensembl_gene_id: C44B7.1.1
symbol: psmd-9
gene_biotype: protein_coding
description:
  Probable 26S proteasome non-ATPase regulatory subunit 9; Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the 19S regulatory complex (RC); Belongs to the proteasome subunit p27 family.


ensembl_gene_id: C44B7.12.1
symbol: C44B7.12
gene_biotype: protein_coding
description:
  Adenosine deaminase-like protein; Catalyzes the hydrolysis of the free cytosolic methylated adenosine nucleotide N(6)-methyl-AMP (N6-mAMP) to produce inositol monophosphate (IMP) and methylamine. Is required for the catabolism of cytosolic N6-mAMP, which is derived from the degradation of mRNA containing N6-methylated adenine (m6A); Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.


ensembl_gene_id: C44B7.3.1
symbol: aff-1
gene_biotype: protein_coding
description:
  Cell fusion protein aff-1; Required for cell fusion events during development including the fusion of anchor cells (AC), vulval A and vulval D rings, and late epidermal seam cells. Required for amphid sheath cell fusion induced by entry into dauer stage.


ensembl_gene_id: C44B7.4.1
symbol: clhm-1
gene_biotype: protein_coding
description:
  Calcium homeostasis modulator protein; Pore-forming subunit of a voltage-gated ion channel. Permeable to monovalent cations, divalent cations and anions with selectivity Ca(2+) > Mg(2+) > Na(+) = K(+) > Cl(-). Acts both as a voltage-gated and calcium-activated ion channel. Required for normal locomotion; Belongs to the CALHM family.


ensembl_gene_id: C44C1.3.1
symbol: ncs-1
gene_biotype: protein_coding
description:
  Neuronal calcium sensor 1; Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Can substitute for calmodulin and directly activate PDE, NO synthase, and calcineurin. Regulates associative learning and memory in a calcium dependent manner.


ensembl_gene_id: C44C10.4.1
symbol: smcl-1
gene_biotype: protein_coding
description:
  Structural maintenance of chromosomes-like protein 1; Acts as a modulator of condensin function, possibly by binding to the condensin SMC subunits and thereby inhibiting their function. Negatively regulates the condensin I complex in mitotic chromosome segregation. Negatively regulates the condensin I-like dosage compensation complex, which functions in the regulation of X chromosome-linked gene transcription, by limiting the association of the complex with the X chromosomes.


ensembl_gene_id: C44C8.6.2
symbol: mak-2
gene_biotype: protein_coding
description:
  MAP kinase-activated protein kinase mak-2; Serine/threonine-protein kinase which is involved in maintaining synapse and axon morphology as well as touch neuron axon regeneration after injury by regulating cebp-1 mRNA stability downstream of the dlk-1, mkk-4 and pmk-3 signaling cascade. May play a role in body wall muscle contraction. Plays a role in the formation of muscle connections, also called muscle arm extensions, between the body wall and the motor axons in the dorsal and ventral cord.


ensembl_gene_id: C44E12.3c.1
symbol: twk-17
gene_biotype: protein_coding
description:
  Putative potassium channel subunit n2P17m2-2; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.


ensembl_gene_id: C44E4.6.3
symbol: acbp-1
gene_biotype: protein_coding
description:
  Acyl-CoA-binding protein homolog 1; Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters.


ensembl_gene_id: C44H4.2.1
symbol: let-4
gene_biotype: protein_coding
description:
  Leucine-rich repeat-containing protein let-4; Required for apical extracellular matrix organization and epithelial junction maintenance.


ensembl_gene_id: C44H4.5.1
symbol: tap-1
gene_biotype: protein_coding
description:
  TGF-beta-activated kinase 1 and MAP3K7-binding protein 1; Involved in the Wnt signaling pathway by regulating mom-4 kinase activity.


ensembl_gene_id: C45B11.1a.1
symbol: pak-2
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase pak-2; Serine/threonine-protein kinase which plays a redundant role with pak-1 in embryogenesis but, in contrast to pak-1, is not involved in commissural axon guidance of ventral cord motoneurons or in distal tip cell (DTC) migration.


ensembl_gene_id: C45G3.5.1
symbol: gip-2
gene_biotype: protein_coding
description:
  Gamma-tubulin interacting protein 2; Recruited to hemidesomosomes in early embryonic elongation to direct the nucleation and growth of non-centrosomal microtubules.


ensembl_gene_id: C45G7.2.1
symbol: ilys-2
gene_biotype: protein_coding
description:
  Invertebrate-type lysozyme 2; Has bacteriolytic activity against Gram-positive bacteria (By similarity). May play a role in resistance to Gram-positive bacterium S.aureus infection.


ensembl_gene_id: C45G7.3.1
symbol: ilys-3
gene_biotype: protein_coding
description:
  Invertebrate-type lysozyme 3; Has bacteriolytic activity against Gram-positive bacteria. Plays a role in defense against bacterial pathogens. Involved in pharyngeal grinder function by enabling proper lysis of ingested bacteria; Belongs to the glycosyl hydrolase 22 family. Type-I lysozyme subfamily.


ensembl_gene_id: C45G9.2.1
symbol: C45G9.2
gene_biotype: protein_coding
description:
  Uncharacterized tRNA-dihydrouridine synthase-like protein C45G9.2; Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs; Belongs to the Dus family.


ensembl_gene_id: C45G9.7.1
symbol: C45G9.7
gene_biotype: protein_coding
description:
  Tax1-binding protein 3 homolog; May regulate a number of protein-protein interactions by competing for PDZ domain binding sites.


ensembl_gene_id: C46A5.3a.1
symbol: col-14
gene_biotype: protein_coding
description:
  Cuticle collagen 14; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.


ensembl_gene_id: C46C2.1n.2
symbol: wnk-1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase WNK; Serine/threonine-protein kinase which phosphorylates gck-3. Plays a role in osmotic stress responses during which it increases gpdh-1 translation, likely by phosphorylating gck-3. Essential for larval development and the tubular formation of the excretory canals.


ensembl_gene_id: C46E1.2.1
symbol: gcy-36
gene_biotype: protein_coding
description:
  Soluble guanylate cyclase gcy-36; Plays a central role in social feeding behavior by synthesizing 3',5'-cyclic guanosine monophosphate (cGMP) from GTP. Oxygen, which probably binds to its heme-binding sites, may regulate social behavior by modulating its activity. cGMP is a common second messenger in sensory transduction and is implicated in oxygen sensation. Indeed, C.elegans exhibits a strong behavioral preference for 5-12% oxygen, avoiding higher and lower oxygen levels; a higher level of oxygen inducing a naturally polymorphic social feeding behavior. Involved in avoidance of hyper [...]


ensembl_gene_id: C46F11.1a.1
symbol: unc-93
gene_biotype: protein_coding
description:
  Putative potassium channel regulatory protein unc-93; May contribute to coordination of muscle contraction as regulatory subunit of a nonessential potassium channel complex. Plays a role in the formation of muscle connections, also called muscle arm extensions, between the body wall and the motor axons in the dorsal and ventral cord ; Belongs to the unc-93 family.


ensembl_gene_id: C46F11.2a.1
symbol: gsr-1
gene_biotype: protein_coding
description:
  Glutathione reductase, mitochondrial; Maintains high levels of reduced glutathione in the cytosol. Involved in resistance to oxidative stress and starvation. Together with thioredoxin reductase txtr- 1, required for the reduction of disulfide groups in the cuticle during molting.


ensembl_gene_id: C46H11.3.1
symbol: C46H11.3
gene_biotype: protein_coding
description:
  Probable actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.


ensembl_gene_id: C46H11.4a.1
symbol: lfe-2
gene_biotype: protein_coding
description:
  Inositol-trisphosphate 3-kinase homolog; Probably by regulating inositol 1,4,5-trisphosphate levels, negatively regulates posterior body wall muscle contractions required for defecation and let-23 signaling pathway that controls spermathecal dilation and ovulation. May also regulate ovulation downstream of actin cross-linker fln-1.


ensembl_gene_id: C47A10.5a.1
symbol: ddo-1
gene_biotype: protein_coding
description:
  D-aspartate oxidase 1; Selectively catalyzes the oxidative deamination of D- aspartate and its N-methylated derivative, N-methyl D-aspartate. Highest catalytic efficiency for D-Glu followed by D-Asp and NMDA. May play a role in the egg-laying events and early development of the worm, in addition to quality control of the germ cells. Belongs to the DAMOX/DASOX family.


ensembl_gene_id: C47B2.3.3
symbol: tba-2
gene_biotype: protein_coding
description:
  Tubulin alpha-2 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain; Belongs to the tubulin family.


ensembl_gene_id: C47B2.5.2
symbol: eif-6
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis. Involved in miRNA-mediated gene silencing.


ensembl_gene_id: C47B2.6b.1
symbol: gale-1
gene_biotype: protein_coding
description:
  UDP-glucose 4-epimerase; Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversi [...]


ensembl_gene_id: C47D12.1a.1
symbol: trr-1
gene_biotype: protein_coding
description:
  Transcription-associated protein 1; Influences germ cell fate in hermaphrodites. Acts downstream of tra-2 and tra-3 and through the Tip60 histone acetyltransferase complex to regulate germ cell fate decisions (By similarity). Required for spermatogenesis and embryonic development (By similarity). Acts with tra-2 to promote expression of fog-3 and control male tail development (By similarity). Involved in the negative regulation of vulval development. Belongs to the PI3/PI4-kinase family. TRA1 subfamily.


ensembl_gene_id: C47D2.2.1
symbol: cdd-1
gene_biotype: protein_coding
description:
  Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.


ensembl_gene_id: C47E12.1.1
symbol: sars-1
gene_biotype: protein_coding
description:
  Probable serine--tRNA ligase, cytoplasmic; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec) (By similarity).


ensembl_gene_id: C47E12.4c.3
symbol: pyp-1
gene_biotype: protein_coding
description:
  Inorganic pyrophosphatase 1; Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions. Plays a role in intestinal development and subsequent normal secretory, digestive and absorption functions. Required for larval development.


ensembl_gene_id: C47E12.7.1
symbol: rrp-1
gene_biotype: protein_coding
description:
  Ribosomal RNA processing protein 1 homolog; May be involved in the generation of 28S rRNA. Belongs to the RRP1 family.


ensembl_gene_id: C47E12.8.1
symbol: dhp-2
gene_biotype: protein_coding
description:
  Dihydropyrimidinase 2; Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.


ensembl_gene_id: C47E8.5.3
symbol: hsp-90
gene_biotype: protein_coding
description:
  Heat shock protein 90; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. By stabilizing the receptor-type guanylate cyclase daf-11 or another sig [...]


ensembl_gene_id: C47E8.7.2
symbol: unc-112
gene_biotype: protein_coding
description:
  Protein unc-112; Component of an integrin containing attachment complex, which is required for muscle development and maintenance. Probable regulator of cell-extracellular matrix adhesion. Required during initial muscle assembly to form dense bodies and M-lines.


ensembl_gene_id: C47F8.4.1
symbol: glct-4
gene_biotype: protein_coding
description:
  Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase; Belongs to the glycosyltransferase 43 family.


ensembl_gene_id: C47G2.1.1
symbol: cut-1
gene_biotype: protein_coding
description:
  Cuticlin-1; Component of the cuticles. It forms a ribbon approximately 2 microns wide running along the lateral lines underneath the alae. Contributes to the formation of extracellular envelopes protecting the organism from the environment.


ensembl_gene_id: C47G2.3.1
symbol: C47G2.3
gene_biotype: protein_coding
description:
  Mitochondrial import inner membrane translocase subunit tim-22; Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity).


ensembl_gene_id: C47G2.4.1
symbol: C47G2.4
gene_biotype: protein_coding
description:
  G-protein coupled receptor-associated protein LMBRD2; May associate with G-protein coupled receptors and regulate downstream signaling pathways; Belongs to the LIMR family.


ensembl_gene_id: C47G2.5c.1
symbol: saps-1
gene_biotype: protein_coding
description:
  Serine/threonine-protein phosphatase 6 regulatory subunit; Regulatory subunit of protein phosphatase 6 (PP6) (Probable). In complex with pph-6, promotes actomyosin contractility during cytokinesis by regulating the organization of cortical non-muscle myosin II nmy-2 and thus contributing to correct spindle positioning. Also required for the proper generation of pulling forces on spindle poles during anaphase by regulating the cortical localization of gpr-1, gpr-2 and lin-5. Negatively regulates kinase air-1 localization at the cell cortex ; Belongs to the SAPS family.


ensembl_gene_id: C48A7.1b.1
symbol: egl-19
gene_biotype: protein_coding
description:
  Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.


ensembl_gene_id: C48B4.1.1
symbol: acox-1.5
gene_biotype: protein_coding
description:
  Probable peroxisomal acyl-coenzyme A oxidase 1.5; Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl- CoAs.


ensembl_gene_id: C48B4.4d.1
symbol: ced-7
gene_biotype: protein_coding
description:
  ABC transporter ced-7; Functions in the engulfment of cell corpses during embryonic programmed cell death to translocate molecules that mediate homotypic adhesion between cell surfaces of the dying and engulfing cells.


ensembl_gene_id: C48B6.6a.1
symbol: smg-1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase smg-1; Serine/threonine protein kinase involved in mRNA surveillance. Recognizes the substrate consensus sequence [ST]-Q. Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating smg-2.


ensembl_gene_id: C48B6.8.1
symbol: bbs-9
gene_biotype: protein_coding
description:
  Protein pthb1 homolog; Component of the BBSome complex (By similarity). The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia (By similarity). The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function (By similarity). Required for proper BBSome complex assembly and its ciliary localization. Required for cilia biogenesis and both the assembly and movement of intraflagellar transport proteins along the ciliary axoneme. In ciliated sensory neurons, required for the sens [...]


ensembl_gene_id: C48D1.2a.1
symbol: ced-3
gene_biotype: protein_coding
description:
  Cell death protein 3 subunit p13; Acts as a cysteine protease in controlling programmed cell death (apoptosis) by proteolytically activating or inactivating a wide range of substrates. Component of the egl-1, ced-9, ced-4 and ced-3 apoptotic signaling cascade required for the initiation of programmed cell death in cells fated to die during embryonic and postembryonic development. During oogenesis, required for germline apoptosis downstream of ced-9 and ced-4 but independently of egl-1. By cleaving and activating ced-8, promotes phosphatidylserine exposure on the surface of apoptotic ce [...]


ensembl_gene_id: C48D1.3.1
symbol: cho-1
gene_biotype: protein_coding
description:
  High-affinity choline transporter 1; Imports choline from the extracellular space to the neuron with high affinity. Choline uptake is the rate-limiting step in acetylcholine synthesis. Sodium ion and chloride ion dependent.


ensembl_gene_id: C48D5.1a.1
symbol: nhr-6
gene_biotype: protein_coding
description:
  Nuclear hormone receptor family member nhr-6; Transcriptional activator that induces gene expression by binding to the NGFI-B response element (NBRE) 5'-AAAGGTCA-3'. Required for proper morphogenesis of the spermatheca and the spermatheca-uterine valve formation. Promotes cell proliferation and differentiation of the spermatheca precursor cells during spermatheca development in larval stage L4. Might play a role in promoting G1/S phase progression in the spermatheca precursor cell lineage. Also required for the differentiation of the spermatheca-uterine junction core (sujc) cells which [...]


ensembl_gene_id: C48E7.2.1
symbol: let-611
gene_biotype: protein_coding
description:
  RNA polymerase III subunit C3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.


ensembl_gene_id: C49A1.4a.1
symbol: eya-1
gene_biotype: protein_coding
description:
  Eyes absent homolog 1; Tyrosine protein phosphatase (By similarity). Acts probably as a transcription regulator in the embryonic and postembryonic development of several tissues including pharynx, vulva and gonads. Required for the development of anterior tissues during late embryogenesis. Together with ceh-34, required to specify the coelomocyte fate in embryonic and postembryonic precursors. In the anterior part of the embryo, prevents apoptosis in cells that are not fated to die. Together with ceh-34 activates proapoptotic factor egl-1 expression to promote motor neuron M4 sister ce [...]


ensembl_gene_id: C49F5.1.2
symbol: sams-1
gene_biotype: protein_coding
description:
  Probable S-adenosylmethionine synthase 1; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate; Belongs to the AdoMet synthase family.


ensembl_gene_id: C49F5.4.1
symbol: nhr-167
gene_biotype: protein_coding
description:
  Nuclear hormone receptor family member nhr-167; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family.


ensembl_gene_id: C49G7.11.1
symbol: djr-1.2
gene_biotype: protein_coding
description:
  Glutathione-independent glyoxalase DJR-1.2; Catalyzes the conversion of methylglyoxal (MG) or glyoxal (GO) to D-lactate or glycolic acid respectively in a single glutathione (GSH)-independent step. May play a role in detoxifying endogenously produced glyoxals. Involved in protection against glyoxal-induced cell death. Protects dopaminergic neurons from glyoxal-dependent neuronal degeneration; Belongs to the peptidase C56 family. DJ-1 subfamily.


ensembl_gene_id: C49H3.1.1
symbol: gcy-8
gene_biotype: protein_coding
description:
  Receptor-type guanylate cyclase gcy-8; Guanylate cyclase involved in the production of the second messenger cGMP. Regulates thermotaxis responses in AFD sensory neurons. May regulate AFD neuronal activity such as calcium responses to temperature gradients. Maintains the microvilli receptive ending morphology of the AFD thermosensory neurons by regulating cGMP levels downstream of kcc-3. cGMP levels antagonize the actin cytoskeleton regulator wsp-1.


ensembl_gene_id: C49H3.10b.1
symbol: xpo-3
gene_biotype: protein_coding
description:
  Exportin-T; tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Belongs to the exportin family.


ensembl_gene_id: C50B8.3.1
symbol: nuaf-1
gene_biotype: protein_coding
description:
  Probable complex I intermediate-associated protein 30, mitochondrial; Chaperone protein involved in the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Required for normal growth and reproduction.


ensembl_gene_id: C50C3.6.1
symbol: prp-8
gene_biotype: protein_coding
description:
  Pre-mRNA-splicing factor 8 homolog; Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5' and the 3' splice site.


ensembl_gene_id: C50C3.7.1
symbol: cil-1
gene_biotype: protein_coding
description:
  Inositol polyphosphate 5-phosphatase; Dephosphorylates a number of phosphatidylinositols. Controls the cellular levels and subcellular distribution of phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 3,4,5- trisphosphate. Has a role in sperm activation and motility. Influences the localization of the transient receptor potential polycystin (TRPP) complex proteins lov-1 and pkd-2; Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.


ensembl_gene_id: C50C3.8.1
symbol: bath-42
gene_biotype: protein_coding
description:
  BTB and MATH domain-containing protein 42; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.


ensembl_gene_id: C50C3.9a.1
symbol: unc-36
gene_biotype: protein_coding
description:
  Voltage-dependent calcium channel unc-36; May act as an auxiliary subunit of the unc-2 voltage-gated calcium channel which appears to trigger calcium-activated signaling pathways that control the serotonin response. Inhibiting serotonin sensitivity of the vulval muscles results in egg laying defects. May act in both neurons and muscle cells to enhance motor activity as it is required for coordinated movement. Has a role in neural depolarization- induced calcium influx and pharyngeal pumping. Involved in restricting the expression of the putative olfactory receptor str-2 to only one of  [...]


ensembl_gene_id: C50D2.7.1
symbol: C50D2.7
gene_biotype: protein_coding
description:
  Probable ADP-dependent glucokinase; Catalyzes the phosphorylation of D-glucose to D-glucose 6- phosphate using ADP as the phosphate donor. GDP and CDP can replace ADP, but with reduced efficiency (By similarity); Belongs to the ADP-dependent glucokinase family.


ensembl_gene_id: C50E10.4b.1
symbol: sop-2
gene_biotype: protein_coding
description:
  Polycomb protein sop-2; Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. Also required to repress expression of other genes and for localization of sor-1. Binds RNA.


ensembl_gene_id: C50F2.10.1
symbol: abf-2
gene_biotype: protein_coding
description:
  Antibacterial factor-related peptide 2; Exhibits antimicrobial activity against the Gram-positive bacteria B.subtilis IFO 3134, K.varians MAFF 118076 and S.aureus ATCC 6538P, the Gram-negative bacteria A.tumefaciens MAFF 1001, B.bacteriovorus MAFF 106101 and K.pneumoniae MAFF 519002, and the yeasts C.krusei MAFF 114085, K.thermotolerans MAFF 113848 and T.delbrueckii MAFF 113811.


ensembl_gene_id: C50F4.14a.1
symbol: nstp-10
gene_biotype: protein_coding
description:
  GDP-fucose transporter; Involved in GDP-fucose import from the cytoplasm into the Golgi lumen; Belongs to the TPT transporter family. SLC35C subfamily.


ensembl_gene_id: C50F4.2.1
symbol: pfk-1.2
gene_biotype: protein_coding
description:
  ATP-dependent 6-phosphofructokinase 2; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.


ensembl_gene_id: C50F4.5.1
symbol: his-41
gene_biotype: protein_coding
description:
  Probable histone H2B 3; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.


ensembl_gene_id: C50F7.4.1
symbol: sucg-1
gene_biotype: protein_coding
description:
  Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial; GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.


ensembl_gene_id: C50H2.2a.1
symbol: egl-47
gene_biotype: protein_coding
description:
  Egg laying defective EGL-47A; Belongs to the insect chemoreceptor superfamily. Gustatory receptor (GR) family.


ensembl_gene_id: C51E3.7a.1
symbol: egl-3
gene_biotype: protein_coding
description:
  Neuroendocrine convertase 2; Serine endoprotease which cleaves preproteins at paired basic amino acids. Processes FMRFamide-like (flp) and neuropeptide-like protein (nlp) neuropeptides. Probably by processing flp-1 and flp-18, modulates the neuronal excitation-inhibition balance and thus the level of activity of the locomotor circuit. Regulates sensitivity to mechanosensory stimuli. By processing neuropeptides, modulates basal acetylcholine release at the ventral cord neuromuscular junctions. Probably by processing flp neuropeptides, regulates the turning step of male mating behavior.  [...]


ensembl_gene_id: C52B11.3.1
symbol: dop-4
gene_biotype: protein_coding
description:
  Dopamine receptor 4; Receptor for dopamine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. In terms of antagonist responses, would be classed with the D1-like dopamine receptor group.


ensembl_gene_id: C52B9.1a.1
symbol: cka-2
gene_biotype: protein_coding
description:
  Choline kinase A2; Catalyzes the first step in phosphatidylcholine biosynthesis. May contribute to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine but the activity is much higher with choline. Belongs to the choline/ethanolamine kinase family.


ensembl_gene_id: C52B9.7a.1
symbol: paf-2
gene_biotype: protein_coding
description:
  Platelet-activating factor acetylhydrolase homolog 2; Belongs to the AB hydrolase superfamily. Lipase family.


ensembl_gene_id: C52D10.12.1
symbol: cnnm-1
gene_biotype: protein_coding
description:
  Metal transporter cnnm-1; Probable metal transporter. Probably acts redundantly with the other metal transport proteins cnnm-2, cnnm-3, cnnm-4 and cnnm-5 to regulate Mg(2+) homeostasis. Promotes postembryonic gonad development by regulating Mg(2+) levels, probably via AMPK signaling. Belongs to the ACDP family.


ensembl_gene_id: C52E12.2b.2
symbol: unc-104
gene_biotype: protein_coding
description:
  Kinesin-like protein unc-104; Motor protein involved in microtubule-associated anterograde transport. Regulates the transport of synaptic vesicle precursors in the axon of DA motor neurons. Regulates the polarized sorting of axonal proteins. Essential for the transport of synaptic components during the synaptic remodeling of the DD motor neuron, probably downstream of cdk-5 and/or pct-1/cyy-1 complex. Required for the anterograde transport of neuropeptide-containing dense core vesicles along axons. Involved in necrotic cell death. Belongs to the TRAFAC class myosin-kinesin ATPase super [...]


ensembl_gene_id: C52E12.3.1
symbol: sqv-7
gene_biotype: protein_coding
description:
  UDP-sugar transporter sqv-7; Involved in the import of UDP-glucuronic acid (UDP-GlcA), UDP-N-acetylgalactosamine (UDP-GalNAc) and UDP-galactose (UDP-Gal) from the cytoplasm into the Golgi lumen for the biosynthesis of glycoconjugates that play a pivotal role in development. Involved in the synthesis of chondroitin sulfate and heparan sulfate proteoglycans. Required for embryonic development. Involved in vulva epithelium invagination and embryonic development. Involved in the directed migration of hermaphrodite-specific neurons. Belongs to the TPT transporter family. SLC35D subfamily.


ensembl_gene_id: C52E4.1.1
symbol: cpr-1
gene_biotype: protein_coding
description:
  Gut-specific cysteine proteinase; Thiol protease. Has a role as a digestive enzyme. Belongs to the peptidase C1 family.


ensembl_gene_id: C52E4.3.2
symbol: snr-4
gene_biotype: protein_coding
description:
  Probable small nuclear ribonucleoprotein Sm D2; Required for pre-mRNA splicing. Required for snRNP biogenesis (By similarity).


ensembl_gene_id: C52E4.4.2
symbol: rpt-1
gene_biotype: protein_coding
description:
  26S proteasome regulatory subunit 7; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).


ensembl_gene_id: C52E4.5.2
symbol: mans-2
gene_biotype: protein_coding
description:
  Mannosyl-oligosaccharide 1,2-alpha-mannosidase C52E4.5; Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2) (By similarity).


ensembl_gene_id: C53A5.17.1
symbol: C53A5.17
gene_biotype: protein_coding
description:
  tRNA (guanine(37)-N1)-methyltransferase; Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding; Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.


ensembl_gene_id: C53A5.3.1
symbol: hda-1
gene_biotype: protein_coding
description:
  Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression. Plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in the endoderm determination possibly by repressing end-1 expression. Also involved in vulval development, possibly by repressing lag-2 expression. In association with akir-1, plays a role in regula [...]


ensembl_gene_id: C53B4.7b.1
symbol: bre-1
gene_biotype: protein_coding
description:
  GDP-mannose 4,6 dehydratase 1; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose. Involved in susceptibility to pore- forming crystal toxins in conjunction with bre-2, bre-3, bre-4, and bre-5. Involved in susceptibility to the nematotoxic C.cinerea galectin Cgl2, likely by contributing to the synthesis of N-glycans to which Cgl2 binds. Has a role in determining brood size. Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.


ensembl_gene_id: C53B7.1.1
symbol: rig-3
gene_biotype: protein_coding
description:
  Neuronal immunoglobulin domain-containing protein rig-3; Cell surface protein which plays a role in the plasticity of cholinergic synapses at neuromuscular junctions and in the polarity of the mechanosensory neuron ALM, possibly by antagonizing Wnt signaling.


ensembl_gene_id: C53B7.4.1
symbol: asg-2
gene_biotype: protein_coding
description:
  Probable ATP synthase subunit g 2, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism  [...]


ensembl_gene_id: C53B7.5.1
symbol: odr-10
gene_biotype: protein_coding
description:
  Serpentine receptor class r-10; An odorant receptor which affects chemotaxis to the volatile odorant diacetyl. Specifies AWA neuronal cell fate via the odr-7 pathway; Belongs to the nematode receptor-like protein str family.


ensembl_gene_id: C53D6.3.1
symbol: acc-2
gene_biotype: protein_coding
description:
  Acetylcholine-gated chloride channel subunit acc-2; Acetylcholine-gated chloride channel subunit. Currents in channels are triggered in response to acetylcholine. Channel properties may be modulated by the formation of homomeric and heteromeric channels.


ensembl_gene_id: C54A12.4.1
symbol: drn-1
gene_biotype: protein_coding
description:
  GTP-binding protein drn-1; Displays low GTPase activity and exists predominantly in the GTP-bound form (By similarity). Together with epac-1, may regulate acetylcholine release at the neuromuscular junctions probably downstream of G-protein gsa-1 and adenylate cyclase acy-1.


ensembl_gene_id: C54C6.1.3
symbol: rpl-37
gene_biotype: protein_coding
description:
  60S ribosomal protein L37; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL37 family.


ensembl_gene_id: C54C6.2.1
symbol: ben-1
gene_biotype: protein_coding
description:
  Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.


ensembl_gene_id: C54C6.6.1
symbol: C54C6.6
gene_biotype: protein_coding
description:
  Cilia- and flagella-associated protein 20; Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility; Belongs to the CFAP20 family.


ensembl_gene_id: C54C8.1.1
symbol: nhr-169
gene_biotype: protein_coding
description:
  Nuclear hormone receptor family member nhr-169; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family.


ensembl_gene_id: C54D1.5.1
symbol: lam-2
gene_biotype: protein_coding
description:
  Laminin-like protein lam-2; During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles, probably downstream of the integrin complex formed by pat-2 and pat-3.


ensembl_gene_id: C54D1.6.1
symbol: bar-1
gene_biotype: protein_coding
description:
  Beta-catenin/armadillo-related protein 1; Participates in the Wnt signaling pathway which affects cell fate and may regulate the stem cell divisions of seam cells during larval development. Functions as a transcriptional activator but is dependent on the interaction with pop-1. Involved in maintaining lin-39 Hox expression and regulating glr-1 abundance at the synapses. Required for mab-5 expression during Q neuroblast migration and for oxidative stress-induced daf-16 signaling. Has roles in egg laying, vulva precursor cell fate determination, Q neuroblast migration, posterior ectoderm [...]


ensembl_gene_id: C54D2.5d.3
symbol: cca-1
gene_biotype: protein_coding
description:
  Voltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the low-voltage activated (LVA) group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...]


ensembl_gene_id: C54E4.3.1
symbol: gcy-37
gene_biotype: protein_coding
description:
  Soluble guanylate cyclase gcy-37; Synthesizes cyclic GMP (cGMP) from GTP (By similarity). May play a role in sensory neurons; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.


ensembl_gene_id: C54F6.14.1
symbol: ftn-1
gene_biotype: protein_coding
description:
  Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.


ensembl_gene_id: C54F6.4a.1
symbol: swt-2
gene_biotype: protein_coding
description:
  Sugar transporter SWEET; Mediates sugar transport across membranes. Belongs to the SWEET sugar transporter family.


ensembl_gene_id: C54G4.1c.1
symbol: rskn-2
gene_biotype: protein_coding
description:
  Putative ribosomal protein S6 kinase alpha-2; Serine/threonine kinase that may play a role in mediating the mitogen- and stress-induced effects on transcription. May repress transcription via phosphorylation of 'Ser-1' of histone H2A. May phosphorylate histone H3 (By similarity).


ensembl_gene_id: C55A6.2b.1
symbol: ttll-5
gene_biotype: protein_coding
description:
  Tubulin polyglutamylase ttll-5; Polyglutamylase which preferentially modifies alpha-tubulin (By similarity). Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step (By similarity). Together with ttll-4 and ttll-11, required for male mating. Probably by regulating microtubule stability via the glutamylation of tubulin, negatively regulates axon regrowth after injury in PLM neurons.


ensembl_gene_id: C55A6.9.1
symbol: pafo-1
gene_biotype: protein_coding
description:
  RNA polymerase II-associated factor 1 homolog; Component of the PAF1 complex which is a multifunctional complex involved in transcription initiation via genetic interactions with TATA-binding proteins, elongation and transcription-coupled histone modification.


ensembl_gene_id: C55B7.12b.1
symbol: che-1
gene_biotype: protein_coding
description:
  Transcription factor che-1; Transcription factor essential for the identity of ASE chemosensory neurons. Acts by activating expression of genes that are specific for ASE chemosensory neurons, such as seven-transmembrane receptors or guanylate cyclase. Also required to control the left/right asymmetry in ASE chemosensory neurons by regulating expression of genes such as cog-1 and ceh-36.


ensembl_gene_id: C55B7.2.1
symbol: gly-2
gene_biotype: protein_coding
description:
  Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase; Catalyzes the addition of N-acetylglucosamine (GlcNAc) in beta 1-6 linkage to the alpha-linked mannose of biantennary N-linked oligosaccharides; Belongs to the glycosyltransferase 18 family.


ensembl_gene_id: C55B7.8.1
symbol: dbr-1
gene_biotype: protein_coding
description:
  Lariat debranching enzyme; Cleaves the 2'-5' phosphodiester linkage at the branch point of lariat intron pre-mRNAs after splicing and converts them into linear molecules that are subsequently degraded. It thereby facilitates ribonucleotide turnover. It may also participate in retrovirus replication via an RNA lariat intermediate in cDNA synthesis (By similarity); Belongs to the lariat debranching enzyme family.


ensembl_gene_id: C55B7.9a.3
symbol: mdt-18
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 18; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).


ensembl_gene_id: C55H1.2.1
symbol: gpa-10
gene_biotype: protein_coding
description:
  Guanine nucleotide-binding protein alpha-10 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems; Belongs to the G-alpha family.


ensembl_gene_id: C56A3.7a.1
symbol: cav-2
gene_biotype: protein_coding
description:
  Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can regulate their activity. Thought to have a role in the uptake of lipids and proteins in the intestinal cells; operates in the apical uptake of lipid markers and trafficking of yolk proteins. Affects fecundity and egg laying. Belongs to the caveolin family.


ensembl_gene_id: C56C10.1.1
symbol: vps-33.2
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 33B; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes. Believed to act as a component of the putative CORVET endosomal tethering complex which is proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The CORVET complex is proposed to function as a rab-5 effector to mediate early endoso [...]


ensembl_gene_id: C56C10.12.1
symbol: epg-5
gene_biotype: protein_coding
description:
  Ectopic P granules protein 5; Involved in the maturation of autophagosomes into autolysosomes during starvation-induced autotrophy. Specifically, involved in the clearance of apoptotic cells by promoting the delivery of engulfed apoptotic cells to the lysosome.


ensembl_gene_id: C56C10.8.2
symbol: icd-1
gene_biotype: protein_coding
description:
  Transcription factor BTF3 homolog; May act as a transcription factor that exert a negative effect on the expression of several genes that are transcribed by RNA polymerase II.


ensembl_gene_id: C56G2.3.2
symbol: C56G2.3
gene_biotype: protein_coding
description:
  Uncharacterized protein C56G2.3; Belongs to the class IV-like SAM-binding methyltransferase superfamily. TRM10 family.


ensembl_gene_id: C56G2.6c.1
symbol: let-767
gene_biotype: protein_coding
description:
  Very-long-chain 3-oxooacyl-coA reductase let-767; Required for branched chain fatty acid synthesis. Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. Very long-chain fatty acids (VLCFAs) serve as precursors for ceramide and sphingolipids. May also be required for sterol hormone production; Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.


ensembl_gene_id: C56G2.7b.1
symbol: rpn-13
gene_biotype: protein_coding
description:
  Proteasomal ubiquitin receptor ADRM1 homolog; May function as a proteasomal ubiquitin receptor. May promote the deubiquitinating activity associated with the 26S proteasome. Belongs to the ADRM1 family.


ensembl_gene_id: C56G3.1b.1
symbol: npr-8
gene_biotype: protein_coding
description:
  Probable G-protein coupled receptor npr-8; Not known. Putative receptor; Belongs to the G-protein coupled receptor 1 family.


ensembl_gene_id: C56G7.1.1
symbol: mlc-4
gene_biotype: protein_coding
description:
  Myosin regulatory light chain; Regulates myosin II activity and organization during embryo elongation. May be involved in the organization of mlc-5 into bundles. Required maternally for cytokinesis during meiosis and mitosis in the early embryo and for the establishment of embryonic anterior-posterior polarity.


ensembl_gene_id: CC4.3.2
symbol: smu-1
gene_biotype: protein_coding
description:
  Smu-1 suppressor of mec-8 and unc-52 protein; Involved in pre-mRNA splicing as a component of the spliceosome (By similarity). Selectively regulates alternative splicing of unc-52 exon 17. Thus, smu-1 mutants selectively suppress the effects of unc-52 nonsense mutations in exon 17 by promoting the accumulation of unc-52 isoforms that lack exon 17 and enhance the effects of unc-52 mutations that affect the exon 16 splice donor site. In contrast, smu-1 mutants do not suppress unc-52 nonsense mutations in exon 18.


ensembl_gene_id: CD4.6.1
symbol: pas-6
gene_biotype: protein_coding
description:
  Proteasome subunit alpha type-1; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).


ensembl_gene_id: D1005.1.1
symbol: acly-1
gene_biotype: protein_coding
description:
  Probable ATP-citrate synthase; ATP-citrate synthase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.


ensembl_gene_id: D1009.2a.1
symbol: cyn-8
gene_biotype: protein_coding
description:
  Peptidyl-prolyl cis-trans isomerase 8; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.


ensembl_gene_id: D1014.8.1
symbol: spr-1
gene_biotype: protein_coding
description:
  REST corepressor spr-1; Probable corepressor protein, which probably participates in the transcriptional repression of the presenilin protein hop-1. Probably acts via the formation of a multiprotein complex that deacetylates and demethylates specific sites on histones. Acts redundantly with the transcriptional repressor lin-35 to play a role in vulval morphogenesis and promote germline proliferation ; Belongs to the CoREST family.


ensembl_gene_id: D1025.2.1
symbol: gcsh-1
gene_biotype: protein_coding
description:
  Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.


ensembl_gene_id: D1044.2c.1
symbol: dex-1
gene_biotype: protein_coding
description:
  Dendrite extension defective protein 1; Along with dyf-7, enables neurite growth and maintenance by anchoring amphid dendritic tips during neuron cell body migration in embryonic and larval development.


ensembl_gene_id: D1054.13b.1
symbol: secs-1
gene_biotype: protein_coding
description:
  O-phosphoseryl-tRNA(Sec) selenium transferase; Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl- tRNA(Sec) required for selenoprotein biosynthesis. Belongs to the SepSecS family.


ensembl_gene_id: D1054.2.2
symbol: pas-2
gene_biotype: protein_coding
description:
  Proteasome subunit alpha type-2; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).


ensembl_gene_id: D1073.1b.1
symbol: trk-1
gene_biotype: protein_coding
description:
  Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. Tyr protein kinase family.


ensembl_gene_id: D2007.5.1
symbol: atg-13
gene_biotype: protein_coding
description:
  Autophagy-related protein 13 homolog; Component of the unc-51/atg-13 complex required for autophagosome formation. Required for the degradation of germ cell specific P-granule components such as sepa-1 by autophagy in somatic cells. This ensures exclusive localization of the P-granules in germ cells. May function downstream of the let-363 (Tor) signaling pathway to mediate sepa-1 degradation. Plays a role in survival during limited food availability ; Belongs to the ATG13 family. Metazoan subfamily.


ensembl_gene_id: D2013.5.1
symbol: eat-3
gene_biotype: protein_coding
description:
  Dynamin-type G domain-containing protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.


ensembl_gene_id: D2013.7.1
symbol: eif-3.F
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 3 subunit F; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.


ensembl_gene_id: D2013.9.1
symbol: ttll-12
gene_biotype: protein_coding
description:
  Tubulin--tyrosine ligase-like protein 12; Regulates microtubule dynamics in uterine muscle cells. Belongs to the tubulin--tyrosine ligase family.


ensembl_gene_id: D2023.2a.2
symbol: pyc-1
gene_biotype: protein_coding
description:
  Pyruvate carboxylase 1; Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.


ensembl_gene_id: D2024.3.1
symbol: elo-3
gene_biotype: protein_coding
description:
  Putative fatty acid elongation protein 3; Could be implicated in synthesis of very long chain fatty acids (By similarity). May be required for normally rapid growth. Belongs to the ELO family.


ensembl_gene_id: D2024.6.2
symbol: cap-1
gene_biotype: protein_coding
description:
  F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.


ensembl_gene_id: D2030.10a.2
symbol: aex-1
gene_biotype: protein_coding
description:
  C2 domain-containing protein aex-1; Involved in retrograde signaling from post-synaptic cells to pre-synaptic neurons, probably by regulating vesicle exocytosis in post-synaptic cells. Acts in muscles, to regulate the localization of synaptic vesicle fusion protein unc-13 likely during vesicle exocytosis and thus regulate retrograde signaling at the neuromuscular junction (NMJ). Regulates anterior body muscle contractions (aBOC) and the expulsion steps during the defecation motor program (DMP). Probably by regulating DMP, plays a homeostatic role in the uptake of triglycerides. Regulat [...]


ensembl_gene_id: D2030.4.1
symbol: D2030.4
gene_biotype: protein_coding
description:
  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).


ensembl_gene_id: D2030.9a.2
symbol: wdr-23
gene_biotype: protein_coding
description:
  DDB1- and CUL4-associated factor 11 homolog; Involved in regulation of lifespan. Required for dopaminergic CEP neuron degeneration in response to Mn(2+).


ensembl_gene_id: D2045.1d.1
symbol: atx-2
gene_biotype: protein_coding
description:
  Ataxin-2 homolog; Probable RNA-binding protein that negatively regulates the translation of targets. Functions with RNA-binding protein szy-20 to ensure embryonic cell division, and to this end, plays a role in the regulation of centrosome assembly, position and size, and in astral microtubule outgrowth and nucleation. Required for gonad development, germ cell proliferation and for the production of oocytes. Regulates whole body growth and fat accumulation in response to food availability, and this may be through the mTOR pathway, upstream of daf-15 and rheb-1. Belongs to the ataxin-2  [...]


ensembl_gene_id: D2045.6.1
symbol: cul-1
gene_biotype: protein_coding
description:
  Cullin-1; Probable core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Required for developmentally programmed transitions from the G1 phase of the cell cycle to the G0 phase or the apoptotic pathway.


ensembl_gene_id: D2085.1.1
symbol: pyr-1
gene_biotype: protein_coding
description:
  Glutamine-dependent carbamoyl-phosphate synthase; This protein is a 'fusion' protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) (By similarity). Involved in the elongation of the pharyngeal isthmus during development, probably by providing precursors of UDP- sugars required for heparan sulfate proteoglycan biosynthesis. Regulates the organization of the actin and intermediate filaments cytoskeleton in the pharyngeal muscles ; In the central section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily.


ensembl_gene_id: D2085.4.1
symbol: etc-1
gene_biotype: protein_coding
description:
  E3 ubiquitin-protein ligase etc-1; E3 ubiquitin-protein ligase that accepts ubiquitin from E2 ubiquitin-conjugating enzymes, such as ubc-18, in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ify-1 and cyb-1 targeting them for degradation in post-meiotic embryos.


ensembl_gene_id: D2089.5.1
symbol: gbh-1
gene_biotype: protein_coding
description:
  Probable gamma-butyrobetaine dioxygenase; Catalyzes the formation of L-carnitine from gamma- butyrobetaine.


ensembl_gene_id: DY3.1.1
symbol: tin-13
gene_biotype: protein_coding
description:
  Mitochondrial import inner membrane translocase subunit tim-13; Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The tim-8- tim-13 complex mediates the import of some pro [...]


ensembl_gene_id: DY3.2.2
symbol: lmn-1
gene_biotype: protein_coding
description:
  Lamin-1; Major component of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane. Provides a framework for the nuclear envelope and probably also interacts with chromatin. Essential to maintain the shape and integrity of the nucleus, and for DNA replication. Involved in spatial organization of nuclear pore complexes. It is not a target for ced-3 during apoptosis, suggesting that lamin cleavage is not essential for apoptosis in C.elegans. Belongs to the intermediate filament family.


ensembl_gene_id: DY3.4a.2
symbol: trt-1
gene_biotype: protein_coding
description:
  Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.


ensembl_gene_id: DY3.7.1
symbol: sup-17
gene_biotype: protein_coding
description:
  Disintegrin and metalloproteinase domain-containing protein 10 homolog; Metalloprotease (By similarity). Acts together with protease adm-4 and in a cell autonomous manner to facilitate lin-12/Notch signaling during developmental cell fate decision, including anchor cell/ventral uterine precursor cell decision and vulva precursor cell specification. By modulating lin-12/Notch signaling, plays a role in germline development. Probably by modulating BMP-like Sma/Mab signaling via the shedding of unc-40 ectodomain, involved in the regulation of body size and mesoderm development. Probably b [...]


ensembl_gene_id: E01A2.2a.1
symbol: E01A2.2
gene_biotype: protein_coding
description:
  Serrate RNA effector molecule homolog; Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex, thereby playing a role in RNA- mediated gene silencing (RNAi) by miRNAs (By similarity).


ensembl_gene_id: E01A2.3.1
symbol: lin-44
gene_biotype: protein_coding
description:
  Abnormal cell lineage protein 44; Ligand for members of the frizzled family of seven transmembrane receptors (By similarity). Affects male tail development, vulval precursor cell specification and egg laying. Involved in morphogenesis by influencing polarity of asymmetric cell divisions of the B, U, and F cells in the male, and the T cell in males and hermaphrodites. Controls spindle orientation in B-gamma cell division during male copulatory spicule development. Involved in specification of the P7.p lineage during vulval development. Has a role in providing polarity and default lin-17 [...]


ensembl_gene_id: E01A2.5.1
symbol: E01A2.5
gene_biotype: protein_coding
description:
  Diphthine--ammonia ligase; Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP.


ensembl_gene_id: E01A2.6.2
symbol: akir-1
gene_biotype: protein_coding
description:
  Akirin homolog; Plays a role in antifungal innate immunity. Forms a complex with components of the NuRD (Nucleosome Remodeling and Deacetylase) and MEC chromatin remodeling complexes which binds to the promoters of antimicrobial peptide genes and may recruit other proteins such as ceh-18 to control gene expression in response to fungal infection. During meiotic prophase I, plays a role in the disassembly of synaptonemal complex proteins and in the regulation of chromosome condensation and segregation. Not required for chromosome pairing or recombination during meiosis ; Belongs to the  [...]


ensembl_gene_id: E01H11.1c.1
symbol: pkc-2
gene_biotype: protein_coding
description:
  Protein kinase C-like 2; PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.


ensembl_gene_id: E02A10.1.1
symbol: mrps-5
gene_biotype: protein_coding
description:
  Putative 28S ribosomal protein S5, mitochondrial; Belongs to the universal ribosomal protein uS5 family.


ensembl_gene_id: E02C12.5a.1
symbol: gpa-3
gene_biotype: protein_coding
description:
  Guanine nucleotide-binding protein alpha-3 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Promotes transcription of 3',5'-cyclic phosphodiesterases pde- 1 and pde-5, leading to reduced cGMP levels in sensory neurons. This causes suppression of insulin production and signaling which leads to increased daf-16 activity and contributes to increased adult lifespan and resistance to oxidative stress. In addition, by reducing cGMP levels, inhibits TGF-beta signaling pathways. Involved in behaviora [...]


ensembl_gene_id: E02H1.1.2
symbol: E02H1.1
gene_biotype: protein_coding
description:
  Probable dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle.


ensembl_gene_id: E02H1.2.1
symbol: eral-1
gene_biotype: protein_coding
description:
  Uncharacterized GTP-binding protein E02H1.2; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.


ensembl_gene_id: E02H1.3.1
symbol: tag-124
gene_biotype: protein_coding
description:
  Probable tRNA pseudouridine synthase tag-124; Formation of pseudouridine at position 38 and 39 in the anticodon stem and loop of transfer RNAs; Belongs to the tRNA pseudouridine synthase TruA family.


ensembl_gene_id: E02H1.4.1
symbol: parp-2
gene_biotype: protein_coding
description:
  Poly [ADP-ribose] polymerase 2; Poly[ADP-ribose] polymerase modifies various nuclear proteins by poly(ADP-ribosyl)ation, a post-translational modification synthesized after DNA damage that appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks and programmed cell death.


ensembl_gene_id: E02H1.6.1
symbol: E02H1.6
gene_biotype: protein_coding
description:
  Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. AMP and dAMP are the preferred substrates, but CMP and TMP are also good substrates. ATP and dATP are the best phosphate donors. May have a role in nuclear energy homeostasis; Belongs to the adenylate kinase family. AK6 subfamily.


ensembl_gene_id: E02H4.1a.1
symbol: del-1
gene_biotype: protein_coding
description:
  Degenerin del-1; Probable sodium channel subunit; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.


ensembl_gene_id: E02H4.3e.1
symbol: madd-3
gene_biotype: protein_coding
description:
  Probable dual specificity protein kinase madd-3; [Isoform a]: Probable dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Negatively regulates p38 MAPK signaling to allow for the plasma membrane of body wall muscle cells to form projections, also called muscle arms, that extend and connect the body wall muscles to target motor neurons. Negative regulation of p38 MAPK signaling may in turn modulate the trafficking of the muscle specific receptor eva-1 to the lysosome, to ensure proper display of the eva-1 receptor on the plasma membrane of muscle [...]


ensembl_gene_id: E02H9.8b.2
symbol: nhr-121
gene_biotype: protein_coding
description:
  Nuclear hormone receptor family member nhr-121; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family.


ensembl_gene_id: E03A3.3.1
symbol: his-69
gene_biotype: protein_coding
description:
  Putative histone H3.3-like type 3; Putative variant histone H3 which may replace conventional H3 in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).


ensembl_gene_id: E03A3.4.1
symbol: his-70
gene_biotype: protein_coding
description:
  Histone H3.3-like type 1; Putative variant histone H3 which may replace conventional H3 in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).


ensembl_gene_id: E03H4.13.1
symbol: nhr-89
gene_biotype: protein_coding
description:
  Nuclear hormone receptor family member nhr-89; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family.


ensembl_gene_id: E03H4.6.1
symbol: nhr-174
gene_biotype: protein_coding
description:
  Nuclear hormone receptor family member nhr-174; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family.


ensembl_gene_id: E04A4.4a.1
symbol: hoe-1
gene_biotype: protein_coding
description:
  Ribonuclease Z; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity). Involved in germline proliferation. May be required for both mitosis and meiosis in germ cells.


ensembl_gene_id: E04A4.5.1
symbol: timm-17B.1
gene_biotype: protein_coding
description:
  Probable mitochondrial import inner membrane translocase subunit tim-17B.1; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane; Belongs to the Tim17/Tim22/Tim23 family.


ensembl_gene_id: E04A4.7.1
symbol: cyc-2.1
gene_biotype: protein_coding
description:
  Cytochrome c 2.1; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.


ensembl_gene_id: E04D5.1a.2
symbol: eif-2A
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 2A; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl- tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner; Belongs to the WD repeat EIF2A family.


ensembl_gene_id: E04F6.11i.1
symbol: clh-3
gene_biotype: protein_coding
description:
  Chloride channel protein clh-3; [Isoform a]: Voltage-gated chloride channel. Insensitive to depolarizing conditioning voltages, requires low voltages for activation, insensitive to chloride levels and has a mild sensitivity to low pH. Channel gating properties are conferred by the cytoplasmic C-terminus. Plays a role in egg laying by modulating hermaphrodite-specific neurons (HSN) excitability and the ovulatory contractions of gap-junction-coupled gonadal sheath cells. When active, may prevent tubular formation of the excretory canals. Activated during oocyte meiotic maturation and by  [...]


ensembl_gene_id: EEED8.1.2
symbol: tofu-6
gene_biotype: protein_coding
description:
  Embryonic developmental protein tofu-6; Required maternally for early embryonic cell divisions. May have a role in DNA replication.


ensembl_gene_id: EEED8.16.1
symbol: brap-2
gene_biotype: protein_coding
description:
  BRCA1-associated protein homolog 2; Controls the stress response to increased levels of reactive oxygen species by modulating the brc-1-dependent expression of cki-1.


ensembl_gene_id: EEED8.2.1
symbol: EEED8.2
gene_biotype: protein_coding
description:
  Uncharacterized protein EEED8.2; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.


ensembl_gene_id: EEED8.3.1
symbol: EEED8.3
gene_biotype: protein_coding
description:
  Uncharacterized protein EEED8.3; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.


ensembl_gene_id: EEED8.5.1
symbol: mog-5
gene_biotype: protein_coding
description:
  Probable pre-mRNA-splicing factor ATP-dependent RNA helicase mog-5; Could act late in the splicing of pre-mRNA and mediate the release of the spliced mRNA from spliceosomes; Belongs to the DEAD box helicase family. DEAH subfamily. DDX8/PRP22 sub-subfamily.


ensembl_gene_id: EEED8.6.1
symbol: ccpp-6
gene_biotype: protein_coding
description:
  Cytosolic carboxypeptidase 6; Metallocarboxypeptidase that catalyzes the removing of polyglutamate side chains that are present on the gamma-carboxyl group of glutamate residues of tubulin in sensory cilia. Probably via the deglutamylation of tubulin, promotes microtubule stability required for axon regrowth after injury. Also regulates microtubule dynamics in uterine muscle cells. Belongs to the peptidase M14 family.


ensembl_gene_id: EEED8.7a.1
symbol: rsp-4
gene_biotype: protein_coding
description:
  Probable splicing factor, arginine/serine-rich 4; May play a functionally redundant role in embryogenesis. Belongs to the splicing factor SR family.


ensembl_gene_id: EEED8.8.1
symbol: ndx-6
gene_biotype: protein_coding
description:
  Putative nudix hydrolase 6; Probably mediates the hydrolysis of some nucleoside diphosphate derivatives; Belongs to the Nudix hydrolase family.


ensembl_gene_id: EEED8.9.1
symbol: pink-1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase pink-1, mitochondrial; Protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins (By similarity). Plays a role in mitophagy.


ensembl_gene_id: EGAP1.3.1
symbol: zmp-1
gene_biotype: protein_coding
description:
  Matrix metalloproteinase-A; Metalloprotease which, together with cadherin cdh-3 and hemicentin him-4, plays a role in anchor cell (AC) invasion during postembryonic vulval development probably by promoting the degradation of the basement membrane separating the gonad from the vulva epithelium.


ensembl_gene_id: EGAP2.3.2
symbol: pho-1
gene_biotype: protein_coding
description:
  Intestinal acid phosphatase; Acid phosphatase required for normal growth and development. Specifically required for normal gut differentiation.


ensembl_gene_id: EGAP9.2.1
symbol: fut-2
gene_biotype: protein_coding
description:
  Galactoside 2-alpha-L-fucosyltransferase; Selectively catalyzes the addition of fucose in alpha 1-2 linkage to Gal-beta-(1->4)-Xyl-beta-R, Gal-beta-(1->6)-GlcNAc-R, Gal- beta-(1->3)-Gal-beta-(1->4)-Glc and Gal-beta-(1->3)-Gal-beta-(1->4)- Xyl-R acceptors but not Gal-beta-(1->3)-GlcNAc-beta-(1->3)-Gal-beta- (1->4)-Glc. Unlike in mammals, unable to fucosylate Gal-beta-(1->4)- Glc-beta-R.


ensembl_gene_id: F01D4.4.1
symbol: egl-21
gene_biotype: protein_coding
description:
  Carboxypeptidase E; During FMRFamide-like peptide (FaRPs or FLP) and neuropeptide-like protein (NLP) precursor processing, catalyzes the removal of Arg or Lys residues from the C-terminus following the initial endoprotease cleavage. By processing neuropeptides, modulates basal acetylcholine release at the ventral cord neuromuscular junctions. Involved in egg-laying, defecation and locomotion. By processing FLP neuropeptides, regulates the turning step of male mating behavior. Involved in reducing pharyngeal pumping in response to high CO(2) levels.


ensembl_gene_id: F01D4.6a.1
symbol: mec-3
gene_biotype: protein_coding
description:
  Mechanosensory protein 3; Specifies differentiation of the set of six touch receptor neurons. Binds cooperatively as a heterodimer with unc-86 to sites in the mec-3 gene promoter.


ensembl_gene_id: F01E11.5c.1
symbol: tyra-2
gene_biotype: protein_coding
description:
  Tyramine receptor tyra-2; G-protein coupled receptor for tyramine, a known neurotransmitter and neuromodulator and direct precursor of octopamine. Expression in amphidial sensory neurons suggests a role in chemosensation.


ensembl_gene_id: F01F1.13a.1
symbol: mig-21
gene_biotype: protein_coding
description:
  Abnormal cell migration protein 21; Required for determination of left/right asymmetry in nervous system. Acts together with unc-40 to control an initial left-right asymmetric polarization of the Q neuroblasts. Mig-21 and unc-40 may control the asymmetry in Wnt signaling response by restricting posterior polarization to one of the 2 Q neuroblasts. Involved in left- side QL posterior migration. In right-side QR, unc-40 and mig-21 pathways mutually inhibit each other in posterior migration, allowing anterior QR migration.


ensembl_gene_id: F01F1.6.2
symbol: alh-9
gene_biotype: protein_coding
description:
  Putative aldehyde dehydrogenase family 7 member A1 homolog; Belongs to the aldehyde dehydrogenase family.


ensembl_gene_id: F01F1.8a.1
symbol: cct-6
gene_biotype: protein_coding
description:
  T-complex protein 1 subunit zeta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity).


ensembl_gene_id: F01F1.9a.1
symbol: dnpp-1
gene_biotype: protein_coding
description:
  Aspartyl aminopeptidase; Aminopeptidase with specificity towards an acidic amino acid at the N-terminus. Plays a role in membrane trafficking and is specifically involved in the recycling and degradation of endocytic cargo.


ensembl_gene_id: F01G12.5b.1
symbol: let-2
gene_biotype: protein_coding
description:
  Collagen alpha-2(IV) chain; Collagen type IV is specific for basement membranes (Probable). Together with fbl-1 and downstream of metalloprotease mig- 17, recruits nidogen nid-1 to the gonad basement membrane thereby probably inducing basement membrane remodeling required for the directional migration of distal tip cells. Required to restrict presynaptic growth at the neuromuscular junctions in late larval stage and in adult motor neurons. Vital for embryonic development.


ensembl_gene_id: F01G4.2a.1
symbol: ard-1
gene_biotype: protein_coding
description:
  Alcohol/Ribitol Dehydrogenase family; Belongs to the short-chain dehydrogenases/reductases (SDR) family.


ensembl_gene_id: F01G4.6b.1
symbol: F01G4.6
gene_biotype: protein_coding
description:
  Phosphate carrier protein, mitochondrial; Transport of phosphate groups from the cytosol to the mitochondrial matrix; Belongs to the mitochondrial carrier (TC 2.A.29) family.


ensembl_gene_id: F02A9.10.1
symbol: F02A9.10
gene_biotype: protein_coding
description:
  Probable methylcrotonoyl-CoA carboxylase beta chain, mitochondrial; Carboxyltransferase subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3- methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism; Belongs to the AccD/PCCB family.


ensembl_gene_id: F02A9.2a.1
symbol: far-1
gene_biotype: protein_coding
description:
  Fatty-acid and retinol-binding protein 1; Probably binds lipids; Belongs to the fatty-acid and retinol-binding protein (FARBP) family.


ensembl_gene_id: F02A9.3.2
symbol: far-2
gene_biotype: protein_coding
description:
  Fatty-acid and retinol-binding protein 2; Probably binds lipids; Belongs to the fatty-acid and retinol-binding protein (FARBP) family.


ensembl_gene_id: F02A9.4.1
symbol: F02A9.10-2
gene_biotype: protein_coding
description:
  Ribosomal protein L44, mitochondrial; Component of the mitochondrial ribosome. May have a function in the assembly/stability of nascent mitochondrial polypeptides exiting the ribosome.


ensembl_gene_id: F02A9.6.1
symbol: glp-1
gene_biotype: protein_coding
description:
  Protein glp-1; Involved in the specification of the cell fates of the blastomeres, ABa and APa. Proper signaling by glp-1 induces ABa descendants to produce anterior pharyngeal cells, and APa descendants to adopt a different fate. Contributes to the establishment of the dorsal-ventral axis in early embryos. Regulates germ cell mitotic proliferation probably by regulating MAP kinase phosphatase lip-1 expression. Plays a negative role in lifespan.


ensembl_gene_id: F02C12.5.1
symbol: cyp-13B1
gene_biotype: protein_coding
description:
  Putative cytochrome P450 cyp-13B1; Cytochromes P450 are a group of heme-thiolate monooxygenases (Probable). They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics (Probable). May play a role in the regulation of lifespan.


ensembl_gene_id: F02C9.3.1
symbol: tat-6
gene_biotype: protein_coding
description:
  Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.


ensembl_gene_id: F02E8.5.1
symbol: atg-16.1
gene_biotype: protein_coding
description:
  Autophagic-related protein 16.1; Most likely a component of the atg-5-atg-12-atg-16.1/atg-16.2 complex, which is recruited to the preautophagosomal membrane and associates with lgg-2 to promote autophagosome formation. Although its role in autophagosome formation may be distinct to the role of atg-16.2, it functions in a partially redundant manner with atg-16.2 to regulate autophagic processes.


ensembl_gene_id: F02E8.6.1
symbol: ncr-1
gene_biotype: protein_coding
description:
  NPC intracellular cholesterol transporter 1 homolog 1; Involved in the uptake or utilization of cholesterol (By similarity). Ncr-1 and ncr-2 act redundantly to prevent dauer larva formation under favorable growth conditions, and are required for the normal functioning of ADF, ASI and ASG neurons. Belongs to the patched family.


ensembl_gene_id: F02E9.2a.1
symbol: lin-28
gene_biotype: protein_coding
description:
  Protein lin-28; Heterochronic protein which controls the choice of stage specific cell fates. Regulates the timing of the second larval stage events (L2 events) in the hypodermis. May negatively regulate the larval to adult transition via the suppression of the microRNA (miRNA) let-7 during L3. Plays a role in the control of seam cell number and vulval development. Belongs to the lin-28 family.


ensembl_gene_id: F02E9.4b.1
symbol: sin-3
gene_biotype: protein_coding
description:
  Paired amphipathic helix protein sin-3; Probable transcriptional repressor required for the deposition of dimethylated 'Lys-9' of histone H3 (H3K9me2) on asynapsed chromosome pairs (both autosomes and sex chromosomes) during meiosis, but this does not seem to solely affect the transcriptional status. Plays a role in ray fusion and patterning in the male tail, and this may be through activity of the histone deacetylase complex (HDAC).


ensembl_gene_id: F07A11.3.1
symbol: npp-5
gene_biotype: protein_coding
description:
  Nuclear pore complex protein 5; Involved in kinetochore assembly and chromosome segregation during embryonic mitosis. Required for the localization of the NDC80 complex member him-10, the chromosomal passenger complex component air- 2 and nuclear pore complex proteins npp-23 and npp-15 to kinetochores during metaphase. Required for npp-23 localization to the nuclear envelope during interphase. Recruits mdf-1, a component of the spindle assembly checkpoint, to the nuclear envelope. Appears dispensable for the assembly of the nuclear pore complex and for nuclear protein import.


ensembl_gene_id: F07A11.5.1
symbol: F07A11.5
gene_biotype: protein_coding
description:
  Ribokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.


ensembl_gene_id: F07A11.6b.1
symbol: din-1
gene_biotype: protein_coding
description:
  Daf-12-interacting protein 1; [Isoform d]: Probable transcriptional corepressor which modulates activity of the nuclear hormone receptor daf-12 to regulate the dauer diapause.


ensembl_gene_id: F07A5.7a.2
symbol: unc-15
gene_biotype: protein_coding
description:
  Paramyosin; Structural component of the muscle thick filaments which is involved in assembly and organization of sarcomere myofilaments. Involved in ovulation. Plays a role in the formation of muscle connections, also called muscle arm extensions, between the body wall and the motor axons in the dorsal and ventral cord. Belongs to the paramyosin family.


ensembl_gene_id: F07B7.11.1
symbol: his-54
gene_biotype: protein_coding
description:
  Histone H2B 2; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.


ensembl_gene_id: F07C3.4.1
symbol: glo-4
gene_biotype: protein_coding
description:
  X-linked retinitis pigmentosa GTPase regulator homolog; Could be a guanine-nucleotide releasing factor for glo-1. May play a role in gut granule biogenesis. Regulates axon termination in PLM and ALM neurons.


ensembl_gene_id: F07D10.1.1
symbol: rpl-11.2
gene_biotype: protein_coding
description:
  60S ribosomal protein L11-2; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome throu [...]


ensembl_gene_id: F07D3.2.1
symbol: flp-6
gene_biotype: protein_coding
description:
  FMRFamide-like neuropeptides 6; FMRFamides and FMRFamide-like peptides are neuropeptides. KSAYMRF-amide has an excitatory effect on dissected pharyngeal myogenic muscle system; Belongs to the FARP (FMRFamide related peptide) family.


ensembl_gene_id: F07F6.5.1
symbol: dct-5
gene_biotype: protein_coding
description:
  Protein dct-5; Acts downstream of daf-16/foxo to suppress tumors induced by disruption of gld-1. Potentially a direct target of daf-15/foxo.


ensembl_gene_id: F07F6.6.2
symbol: nmr-1
gene_biotype: protein_coding
description:
  NMDA-type ionotropic glutamate receptor NMR-1; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.


ensembl_gene_id: F08A8.5b.1
symbol: F08A8.5
gene_biotype: protein_coding
description:
  Galactoside 2-alpha-L-fucosyltransferase; Selectively catalyzes the addition of fucose in alpha 1-2 linkage to Gal-beta-(1->3)-GalNAc-alpha-R, Gal-beta-(1->3)-(GlcNAc- beta-(1->6))-GalNAc-alpha-R and Gal-beta-(1->3)-GalNAc acceptors but not Gal-beta-(1->3)-GlcNAc-beta-(1->3)-Gal-beta-(1->4)-Glc in vitro.


ensembl_gene_id: F08B1.1e.1
symbol: vhp-1
gene_biotype: protein_coding
description:
  Tyrosine-protein phosphatase vhp-1; Acts preferentially on the c-Jun N-terminal kinase (JNK) and p38 MAPKs. Plays an important role in the heavy metal stress response and in axon regeneration by negatively regulating the kgb-1 (JNK-like) and the pmk-1 (p38-type) MAPK signaling pathways. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.


ensembl_gene_id: F08B1.2a.1
symbol: gcy-12
gene_biotype: protein_coding
description:
  Receptor-type guanylate cyclase gcy-12; Guanylate cyclase involved in the production of the second messenger cGMP. Acts upstream of cGMP-dependent protein kinase egl-4, most likely by providing cGMP to the kinase in chemosensory neurons to regulate body size.


ensembl_gene_id: F08B12.2.1
symbol: prx-12
gene_biotype: protein_coding
description:
  Putative peroxisome assembly protein 12; Required for protein import into peroxisomes; Belongs to the pex2/pex10/pex12 family.


ensembl_gene_id: F08B4.5.1
symbol: pole-2
gene_biotype: protein_coding
description:
  Probable DNA polymerase epsilon subunit 2; Accessory component of the DNA polymerase epsilon complex (By similarity). Participates in DNA repair and in chromosomal DNA replication (By similarity).


ensembl_gene_id: F08B4.6.1
symbol: hst-1
gene_biotype: protein_coding
description:
  Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1; Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis (Probable).


ensembl_gene_id: F08B4.7.1
symbol: F08B4.7
gene_biotype: protein_coding
description:
  U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.


ensembl_gene_id: F08B6.4a.2
symbol: unc-87
gene_biotype: protein_coding
description:
  Protein unc-87; Thin filament-associated protein that is implicated in actin bundling and actin filament dynamics. Exhibits F-actin cross-linking activity. Required for the maintenance of sarcomeric actin organization in striated muscles. Competes with unc-60 isoform b for actin binding and protects actin filaments from depolymerization by unc-60, thereby contributing to actin filament stability. Cooperates with myosin to form actomyosin bundles and inhibits actomyosin ATPase activity and actomyosin motility. Might protect the myofilaments from mechanical stress.


ensembl_gene_id: F08C6.1a.2
symbol: adt-2
gene_biotype: protein_coding
description:
  A disintegrin and metalloproteinase with thrombospondin motifs adt-2; Regulates body size probably independently of the TGF beta- like dbl-1 pathway. However, may regulate some dbl-1-mediated transcription. Plays a role in cuticle collagen fibril organization. Required for embryonic development.


ensembl_gene_id: F08C6.3.1
symbol: vps-52
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 52 homolog; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex facilitates tethering as well as SNARE complex assembly at the Golgi. Plays a role in the trafficking of cargo to dense-core vesicles, probably through association with the EARP-interacting protein eipr-1. Important for neuronal function. Belongs to the VPS52 family.


ensembl_gene_id: F08C6.6.1
symbol: apy-1
gene_biotype: protein_coding
description:
  Apyrase apy-1; Hydrolyzes UDP and to a lesser extent GDP. By preventing the accumulation of NDP, may promote the reglucosylation of incompletely folded glycoproteins in the endoplasmic reticulum following the unfolded protein response.


ensembl_gene_id: F08C6.7.1
symbol: unc-98
gene_biotype: protein_coding
description:
  Zinc finger protein unc-98; Probable transcription factor required for muscle structure. Its dual subcellular localization suggests that it may function both as a muscle adhesion complex protein and as a transcription factor, or work together with transcription factors, to influence gene expression. Thought to act as a molecular bridge between unc-97 and myo-3 at the M-line of muscles, possibly in a signaling role. Plays a role in the formation of muscle connections, also called muscle arm extensions, between the body wall and the motor axons in the dorsal and ventral cord.


ensembl_gene_id: F08D12.1.1
symbol: srpa-72
gene_biotype: protein_coding
description:
  Signal recognition particle subunit SRP72; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. Binds the 7S RNA only in presence of SRP68. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function (By similarity).


ensembl_gene_id: F08F1.5.1
symbol: ced-8
gene_biotype: protein_coding
description:
  Cell death abnormality protein 8; Acts downstream of ced-9 and caspase ced-3 to promote phosphatidylserine exposure on apoptotic cell surface, possibly by mediating phospholipid scrambling. Phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment. Regulates apoptosis kinetics during embryonic development. Not required for engulfment of germ cell corpses. Belongs to the XK family.


ensembl_gene_id: F08F1.8.1
symbol: tth-1
gene_biotype: protein_coding
description:
  Thymosin beta; Plays an important role in the organization of the cytoskeleton by regulating actin polymerization in two ways. Firstly, by binding to and sequestering actin monomers (G actin) inhibits actin polymerization. Secondly, by binding directly filamentous actin (F actin) promotes actin polymerization. Regulates the formation of cortical actin in oocytes conferring them enough rigidity to sustain the contractions during ovulation.


ensembl_gene_id: F08F8.8.1
symbol: gos-28
gene_biotype: protein_coding
description:
  Golgi SNAP receptor complex member 1; Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. Cooperates with ykt-6 for proper expression of Golgi-resident proteins. Required along with ykt-6 for normal embryonic development, seam cell division or differentiation, and ray formation.


ensembl_gene_id: F08G12.4.1
symbol: vhl-1
gene_biotype: protein_coding
description:
  Von Hippel-Lindau tumor suppressor homolog; Involved in the response to variation in environmental oxygen levels by targeting the hypoxia-inducible transcription factor hif-1 for proteasomal degradation when oxygen levels are normal (around 20%). By regulating hif-1 expression, plays a role in iron homeostasis, aging, heat acclimation and progeny size. Mediates resistance to enteropathogenic E.coli. Mediates susceptibility to B.thuringiensis pore-forming toxins. Not involved in P.aeruginosa susceptibility. Belongs to the VHL family.


ensembl_gene_id: F08G2.1.1
symbol: his-44
gene_biotype: protein_coding
description:
  Histone H2B 1; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.


ensembl_gene_id: F09A5.2.1
symbol: F09A5.2
gene_biotype: protein_coding
description:
  Putative tyrosine-protein kinase F09A5.2; Belongs to the protein kinase superfamily. Tyr protein kinase family.


ensembl_gene_id: F09B12.3.1
symbol: F09B12.3
gene_biotype: protein_coding
description:
  Putative phospholipase B-like 2; Putative phospholipase; Belongs to the phospholipase B-like family.


ensembl_gene_id: F09B12.6.1
symbol: flr-4
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase flr-4; Probable serine-threonine protein kinase involved in the control of defecation rhythms. Required to increase the length of defecation cycle period. Acts in a cell-functional rather than developmental aspect in the regulation of defecation rhythms.


ensembl_gene_id: F09B9.3.1
symbol: erd-2
gene_biotype: protein_coding
description:
  ER lumen protein-retaining receptor erd-2.1; Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi (By similarity); Belongs to the ERD2 family.


ensembl_gene_id: F09E10.8a.1
symbol: toca-1
gene_biotype: protein_coding
description:
  Transducer of Cdc42-dependent actin assembly protein 1 homolog; Plays a role in protein trafficking, actin organization and embryonic morphogenesis. Potentially acts as cdc-42 effector. May play a role in hypodermal P-cell nuclear positioning. Together with toca-2, is required for protein trafficking regulating yolk protein clathrin- mediated endocytosis by oocytes during oogenesis and retrograde recycling and the sorting of recycling endosome cargo proteins such as mig-14. Also, together with toca-2, controls the distribution of actin at cell junctions.


ensembl_gene_id: F09E5.1.1
symbol: pkc-3
gene_biotype: protein_coding
description:
  Protein kinase C-like 3; Required for the normal progression of embryogenesis and viability of the organism. Plays an indispensable role in establishing embryonic polarity and in recruiting and maintaining par-6 to the periphery, through interaction with par-3. Required for epithelial cell polarity in the distal spermatheca. Phosphorylates serine residues of num-1. Required for the expression of antimicrobial peptide nlp-29 in response in response to fungal infection or physical injury.


ensembl_gene_id: F09E5.3.1
symbol: F09E5.3
gene_biotype: protein_coding
description:
  Putative deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate.


ensembl_gene_id: F09E5.5.1
symbol: sec-6
gene_biotype: protein_coding
description:
  Exocyst complex component 3; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC6 family.


ensembl_gene_id: F09E5.8.1
symbol: F09E5.8
gene_biotype: protein_coding
description:
  Pyridoxal phosphate homeostasis protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'- phosphate (PLP), the active form of vitamin B6.


ensembl_gene_id: F09E8.2a.1
symbol: crld-1
gene_biotype: protein_coding
description:
  Protein disulfide isomerase crld-1; Protein disulfide isomerase which associates with the unc-29 subunit of levamisole-sensitive nicotinic acetylcholine receptors (L- nAChR) to promote L-nAChR assembly in the endoplasmic reticulum at neuromuscular junctions.


ensembl_gene_id: F09E8.3a.1
symbol: msh-5
gene_biotype: protein_coding
description:
  MutS protein homolog 5; Crucial component in meiotic recombination, functioning at some point after the initiation step of recombination. Plays a role in promoting the crossover outcome of meiotic recombination events. Required for formation of normal meiotic crossover, and crossover and chiasmata generated by artificially made DNA breaks.


ensembl_gene_id: F09E8.7a.1
symbol: lev-1
gene_biotype: protein_coding
description:
  Acetylcholine receptor subunit beta-type lev-1; Non-alpha subunit of nicotinic acetylcholine receptor (nAChR). Involved in nAChR sensitivity to nicotine. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.


ensembl_gene_id: F09F3.5.1
symbol: hpx-2
gene_biotype: protein_coding
description:
  Heme peroxidase 2 heavy chain; Peroxidase which is involved in maintaining the cuticle integrity in the hypodermis and pharynx. It thus plays a role in conferring resistance against Gram-positive bacteria such as E.faecalis, S.aureus and C.diphtheriae, and yeast such as C.albicans.


ensembl_gene_id: F09F7.3.2
symbol: rpc-2
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.


ensembl_gene_id: F09F7.4a.2
symbol: hach-1
gene_biotype: protein_coding
description:
  3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.


ensembl_gene_id: F09F7.7a.1
symbol: nmad-1
gene_biotype: protein_coding
description:
  DNA N6-methyl adenine demethylase; Dioxygenase that specifically demethylates DNA methylated on the 6th position of adenine (N(6)-methyladenosine) DNA. N(6)-methyladenosine (m6A) DNA is involved in epigenetic transgenerational inheritance. Plays an essential role in DNA replication and repair in the germline during meiosis. Binds to components of the DNA replication machinery such as top-2, and directs their localization to DNA to control DNA replication.


ensembl_gene_id: F09G2.4.1
symbol: cpsf-2
gene_biotype: protein_coding
description:
  Probable cleavage and polyadenylation specificity factor subunit 2; CPSF plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A)polymerase and other factors to bring about cleavage and poly(A) addition.


ensembl_gene_id: F09G8.3.1
symbol: mrps-9
gene_biotype: protein_coding
description:
  Probable 40S ribosomal protein S9, mitochondrial; Belongs to the universal ribosomal protein uS9 family.


ensembl_gene_id: F09G8.4.1
symbol: ncr-2
gene_biotype: protein_coding
description:
  NPC intracellular cholesterol transporter 1 homolog 2; Involved in the uptake or utilization of cholesterol (By similarity). Ncr-1 and ncr-2 act redundantly to prevent dauer larva formation under favorable growth conditions, and are required for the normal functioning of ADF, ASI and ASG neurons. Belongs to the patched family.


ensembl_gene_id: F09G8.6.1
symbol: col-91
gene_biotype: protein_coding
description:
  Putative cuticle collagen 91; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment (By similarity).


ensembl_gene_id: F10B5.4.1
symbol: tub-1
gene_biotype: protein_coding
description:
  Tubby protein homolog 1; Has a role in fat regulation independent of daf-16. Implicated in ciliar sensory function which is required for normal sensory behavior such as chemotaxis. Functions in life span control via the insulin/IGF-1 pathway. Thought to be involved in neuronal trafficking.


ensembl_gene_id: F10B5.5.1
symbol: pch-2
gene_biotype: protein_coding
description:
  Putative pachytene checkpoint protein 2; Plays a key role in chromosome recombination during meiosis.


ensembl_gene_id: F10B5.6.1
symbol: emb-27
gene_biotype: protein_coding
description:
  Cell division cycle protein 16 homolog; Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (By similarity). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins (By similarity). Developmental role in early embryogenesis and the metaphase to anaphase transition in oocyte and spermatocyte meiosis and mitosis in germ cells. Required for embryonic anterior-posterior axis formation. Plays a role in regulating [...]


ensembl_gene_id: F10C1.2b.1
symbol: ifb-1
gene_biotype: protein_coding
description:
  Intermediate filament protein ifb-1; Cytoplasmic intermediate filaments provide mechanical strength to cells. Essential protein, involved in attachment structures in epidermal cells that connect muscles to the external cuticle. Required in morphogenesis and epidermal integrity. Probable component of embryonic epidermal attachment structures. Functions in larval muscle attachment independently of ifa-2.


ensembl_gene_id: F10C1.7e.1
symbol: ifb-2
gene_biotype: protein_coding
description:
  Intermediate filament protein ifb-2; Cytoplasmic intermediate filaments provide mechanical strength to cells. Not essential protein. Component of the terminal web (organelle-depleted, intermediate filament-rich layer of cytoplasm that underlies the apical microvilli of polarized epithelial cells) in embryonic through to adult gut cells. Correct localization of filaments requires let-413.


ensembl_gene_id: F10C2.4.1
symbol: F10C2.4
gene_biotype: protein_coding
description:
  DNA polymerase delta catalytic subunit; Possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction. Required with its accessory proteins (proliferating cell nuclear antigen (PCNA) and replication factor C (RFC) or activator 1) for leading strand synthesis. Also involved in completing Okazaki fragments initiated by the DNA polymerase alpha/primase complex (By similarity).


ensembl_gene_id: F10C5.1.1
symbol: mat-3
gene_biotype: protein_coding
description:
  Cell division cycle protein 23 homolog; Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins. Developmental role in early embryogenesis and the metaphase to anaphase transition in oocyte and spermatocyte meiosis and mitosis in germ cells. Required for embryonic anterior-posterior axis formation. Plays a role in regulating the abundance of glr-1 receptor [...]


ensembl_gene_id: F10D11.1.2
symbol: sod-2
gene_biotype: protein_coding
description:
  Superoxide dismutase [Mn] 1, mitochondrial; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.


ensembl_gene_id: F10D2.9.1
symbol: fat-7
gene_biotype: protein_coding
description:
  Delta(9)-fatty-acid desaturase fat-7; Delta(9)-fatty-acid desaturase that acts preferentially on stearoyl-CoA. Also acts on vaccenyl-coA, heptadecanyol-CoA, and palmitoyl-CoA.


ensembl_gene_id: F10D7.3.1
symbol: F10D7.3
gene_biotype: protein_coding
description:
  Uncharacterized monothiol glutaredoxin F10D7.3; Belongs to the glutaredoxin family. Monothiol subfamily.


ensembl_gene_id: F10E7.5.1
symbol: F10E7.5
gene_biotype: protein_coding
description:
  Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.


ensembl_gene_id: F10E9.6c.2
symbol: mig-10
gene_biotype: protein_coding
description:
  Abnormal cell migration protein 10; Required cell non-autonomously for proper development of the excretory canals and for the long-range anterior-posterior migrations of embryonic neurons CAN, ALM and HSN. Plays a role, probably downstream of ced-10/rac1, in orientating axonal growth of HSN and AVM neurons in response to guidance cues such as slt- 1. May regulate growth cone polarization by promoting asymmetric F-actin assembly. May be involved in signal transduction during cell migration. Belongs to the MRL family.


ensembl_gene_id: F10E9.8.1
symbol: sas-4
gene_biotype: protein_coding
description:
  Spindle assembly abnormal protein 4; Required for centrosome duplication. Plays a central role in determining centrosome size.


ensembl_gene_id: F10F2.1.1
symbol: sel-2
gene_biotype: protein_coding
description:
  Putative neurobeachin homolog; Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins (By similarity). Regulates endosomal traffic in polarized epithelial cells such as the vulval precursor cells and intestinal cells. Thought to act as a negative regulator of lin-12 activity in vulval precursor cells. May have a role in the internalization process from basolateral surface of polarized epithelial cells.


ensembl_gene_id: F10F2.2.1
symbol: pfas-1
gene_biotype: protein_coding
description:
  Probable phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate (By similarity); In the N-terminal section; belongs to the FGAMS family.


ensembl_gene_id: F10G7.1.1
symbol: tag-151
gene_biotype: protein_coding
description:
  Pre-rRNA-processing protein TSR1 homolog; Required during maturation of the 40S ribosomal subunit in the nucleolus; Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. TSR1 subfamily.


ensembl_gene_id: F10G7.10a.1
symbol: F10G7.10
gene_biotype: protein_coding
description:
  E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.


ensembl_gene_id: F10G7.2.1
symbol: tsn-1
gene_biotype: protein_coding
description:
  Staphylococcal nuclease domain-containing protein; Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs.


ensembl_gene_id: F10G7.3.1
symbol: unc-85
gene_biotype: protein_coding
description:
  Probable histone chaperone asf-1; Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly.


ensembl_gene_id: F10G7.4.1
symbol: scc-1
gene_biotype: protein_coding
description:
  Sister chromatid cohesion protein 1; Cleavable component of the cohesin complex involved in chromosome cohesion during cell cycle. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped (By similarity). At metaphase-anaphase transition, this protein is cleaved and dissociates from chromatin, allowing sister chromatids to segregate (By similarity).


ensembl_gene_id: F10G8.3.2
symbol: rae-1
gene_biotype: protein_coding
description:
  mRNA export factor rae-1; Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors (By similarity). It is specifically important for nuclear mRNA export. Has a role in neuronal development, where it acts downstream of rpm-1 to control axon termination and synapse formation in anterior lateral microtubule (ALM) and posterior lateral microtubule (PLM) mechanosensory neurons. Belo [...]


ensembl_gene_id: F10G8.4b.1
symbol: eak-6
gene_biotype: protein_coding
description:
  Tyrosine-protein phosphatase non-receptor type eak-6; Putative phosphatase which, together with eak-4 and sdf-9, negatively regulates dauer larva formation downstream of insulin-like receptor daf-2 and in parallel of age-1, pdk-1 and akt-1.


ensembl_gene_id: F10G8.5.1
symbol: ncs-2
gene_biotype: protein_coding
description:
  Neuronal calcium sensor 2; Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner; Belongs to the recoverin family.


ensembl_gene_id: F10G8.6.1
symbol: nubp-1
gene_biotype: protein_coding
description:
  Cytosolic Fe-S cluster assembly factor NUBP1 homolog; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins (By similarity). Regulates cilium formation and structure ; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.


ensembl_gene_id: F10G8.9b.1
symbol: F10G8.9
gene_biotype: protein_coding
description:
  PKS_KS domain-containing protein; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.


ensembl_gene_id: F11A1.3a.1
symbol: daf-12
gene_biotype: protein_coding
description:
  Nuclear hormone receptor family member daf-12; Nuclear receptor which binds directly to response elements in target gene promoters. Activity is modulated by binding of steroid hormone ligands that include dafachronic acids. Regulates expression of genes involved in postembryonic development and the dauer diapause, in response to environmental cues. Inhibits the expression of let-7 family members when bound to corepressor din-1s which is an isoform of din-1. Has a role in the immune response to bacterial infection, via regulation of let-7 miRNAs. Controls expression of genes that promot [...]


ensembl_gene_id: F11A10.1a.2
symbol: lex-1
gene_biotype: protein_coding
description:
  Tat-binding homolog 7; Thought to form a complex that enhances transcription from repetitive DNA sequences by modulating chromatin structure. Belongs to the AAA ATPase family.


ensembl_gene_id: F11A5.10.2
symbol: glc-1
gene_biotype: protein_coding
description:
  Glutamate-gated chloride channel alpha; Glutamate-gated chloride channel subunit; channel properties depend on the subunit composition. Glutamate binding triggers a rapidly reversible current in heteromeric channels formed by glc-1 and glc-2, while the anti-helmintic drug ivermectin and other avermectins trigger a permanently open channel configuration. Channels containing only glc- 1 are activated by ivermectin, but not by glutamate alone (in vitro). The heteromeric channel formed by glc-1 and glc-2 is also activated by ibotenate, and it is blocked by picrotoxin and flufenamic acid. P [...]


ensembl_gene_id: F11A5.12.1
symbol: stdh-2
gene_biotype: protein_coding
description:
  Putative steroid dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.


ensembl_gene_id: F11A6.1a.1
symbol: kpc-1
gene_biotype: protein_coding
description:
  Furin-like protease kpc-1; Furin-like protease which cleaves proproteins at the RX(K/R)R consensus motif. During neuronal development, regulates the formation and extension of dendrite branches and cellular positioning of various type of neurons. Promotes the formation, extension and self-avoidance of dendritic branches of PVD and FLP mechanosensory neurons. In PVD neurons, regulates plasma membrane levels of branching receptor dma-1 by targeting it to late endosomes and thus promotes normal dendrite branching and dendrite self-avoidance. Also controls dendrite extension in AIY and D-t [...]


ensembl_gene_id: F11C1.6a.1
symbol: nhr-25
gene_biotype: protein_coding
description:
  Nuclear hormone receptor family member nhr-25; Orphan nuclear receptor required during development. Plays a role in male tail tip morphogenesis regulating the expression of the transcription factor dmd-3 in a negative feedback loop.


ensembl_gene_id: F11C3.3.2
symbol: unc-54
gene_biotype: protein_coding
description:
  Myosin-4; Required for muscle contraction. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.


ensembl_gene_id: F11C7.1.1
symbol: pbo-6
gene_biotype: protein_coding
description:
  Proton-gated ion channel subunit pbo-6; Forms a proton-gated ion channel with pbo-5 that is activated by acidification of the posterior coelomic space, leading to posterior body wall muscle contraction (pBoc) during the defecation cycle. Not necessary for stimulation of posterior body contraction (pBoc). Does not bind neurotransmitters such as acetylcholine, gamma-aminobutyric acid, glycine, serotonin, glutamate or choline.


ensembl_gene_id: F11D5.3a.1
symbol: ddr-2
gene_biotype: protein_coding
description:
  Discoidin domain-containing receptor tyrosine kinase B; Tyrosine-protein kinase receptor which, together with ddr-1, is involved in axon guidance to establish the tracts for the ventral and dorsal nerve cords during nervous system development. Acts upstream of the adapter shc-1, and the tyrosine kinase receptors svh-1 and svh-2 to regulate axon regeneration following injury in D-type motor neurons. May mediate axon regeneration in association with the collagen emb-9.


ensembl_gene_id: F11F1.6.1
symbol: mig-18
gene_biotype: protein_coding
description:
  Abnormal cell migration protein 18; Required for the directional control of distal tip cell migration during gonadogenesis, probably by recruiting fibulin fbl-1 to the gonad basement membrane.


ensembl_gene_id: F11F1.7.1
symbol: ttr-52
gene_biotype: protein_coding
description:
  Transthyretin-like protein 52; Plays a role as a bridging molecule that mediates recognition and engulfment of apoptotic cells by cross-linking the surface-exposed phosphatidylserine with the extracellular domain of the phagocyte receptor ced-1. Important for the generation of extracellular phosphatidylserine vesicles that promote loss of the exoplasmic leaflet from apoptotic cells in a time-dependent manner. Required for the exposure of exoplasmic leaflet on the phagocytic cells surrounding the apoptotic cells. Does not affect the phosphatidylserine externalization in living cells. Ma [...]


ensembl_gene_id: F11G11.1.1
symbol: gst-8
gene_biotype: protein_coding
description:
  Probable glutathione S-transferase 8; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Belongs to the GST superfamily. Sigma family.


ensembl_gene_id: F11G11.13.1
symbol: F11G11.13
gene_biotype: protein_coding
description:
  Phosphagen kinase C-terminal domain-containing protein; Belongs to the ATP:guanido phosphotransferase family.


ensembl_gene_id: F11G11.2.1
symbol: gst-7
gene_biotype: protein_coding
description:
  Probable glutathione S-transferase 7; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (By similarity). May play a role in the detoxification of reactive oxygen species produced during pathogenic bacterial infection. Belongs to the GST superfamily. Sigma family.


ensembl_gene_id: F11G11.3.1
symbol: gst-6
gene_biotype: protein_coding
description:
  Probable glutathione S-transferase 6; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Belongs to the GST superfamily. Sigma family.


ensembl_gene_id: F11H8.1.2
symbol: rfl-1
gene_biotype: protein_coding
description:
  NEDD8-activating enzyme E1 catalytic subunit; Catalytic subunit of the dimeric rfl-1 (uba-3)-ula-1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-uba-3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of ubc-12 (By similarity). Required for cytokinesis and mitotic spindle orientation during early embryogenesis.


ensembl_gene_id: F11H8.3.1
symbol: col-8
gene_biotype: protein_coding
description:
  Cuticle collagen 8; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.


ensembl_gene_id: F12E12.5.1
symbol: sdz-12
gene_biotype: protein_coding
description:
  Zinc finger protein sdz-12; Together with ehn-3, may play a role in gonadogenesis. Belongs to the krueppel C2H2-type zinc-finger protein family.


ensembl_gene_id: F12F6.3a.1
symbol: rib-1
gene_biotype: protein_coding
description:
  Exostosin-1 homolog; Required for the biosynthesis of heparan sulfate by positively regulating N-acetylglucosamine transferase II (GlcNAcT-II) and glucuronyl transferase II (GlcAT-II) activities of glycosyltransferase rib-2. Probably not directly involved in chondroitin sulfate biosynthesis but negatively regulates chondroitin sulfate levels. Maternally required for normal ventral epidermal enclosure and for embryo elongation during the early stages of embryonic development. In addition, involved in the elongation of the pharyngeal isthmus and in the organization of the actin cytoskele [...]


ensembl_gene_id: F12F6.7.2
symbol: F12F6.7
gene_biotype: protein_coding
description:
  Probable DNA polymerase delta small subunit; The function of the small subunit is not yet clear; Belongs to the DNA polymerase delta/II small subunit family.


ensembl_gene_id: F13B10.1f.1
symbol: tir-1
gene_biotype: protein_coding
description:
  NAD(+) hydrolase tir-1; NAD(+) hydrolase, which plays a key role in non-apoptotic cell death by regulating NAD(+) metabolism. In response to stress, homooligomerizes and catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR) and nicotinamide; NAD(+) cleavage promoting non-apoptotic neuronal cell death. In males, involved in non-apoptotic death of the linker cell which guides gonad elongation during larval development. Required for both innate immune response and specification of AWC(OFF) neuron. During late embryogenesis, it. acts downstream of CAMKII (unc-43) to regulate specification  [...]


ensembl_gene_id: F13B10.2a.1
symbol: rpl-3
gene_biotype: protein_coding
description:
  60S ribosomal protein L3; The L3 protein is a component of the large subunit of cytoplasmic ribosomes; Belongs to the universal ribosomal protein uL3 family.


ensembl_gene_id: F13B12.4a.2
symbol: F13B12.4
gene_biotype: protein_coding
description:
  Putative pyridoxal-phosphate dependent protein F13B12.4; Belongs to the cysteine synthase/cystathionine beta- synthase family. Highly divergent.


ensembl_gene_id: F13B9.5.2
symbol: ksr-1
gene_biotype: protein_coding
description:
  Kinase suppressor of Ras A; Serine/threonine-protein kinase which positively regulates Ras-mediated signaling probably acting at the level of let-60/ras or/and lin-45/raf. Involved in sex myoblast migration. Plays a role in responses to M.nematophilum-mediated bacterial infection by promoting tail swelling and preventing constipation. Functions redundantly with ksr-2 in the Ras-mediated regulation of larval survival, the development of excretory canal and in mpk-1 phosphorylation in somatic cells. In addition, involved in determining vulval precursor cell fate during vulval induction i [...]


ensembl_gene_id: F13B9.8b.1
symbol: fis-2
gene_biotype: protein_coding
description:
  Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering.


ensembl_gene_id: F13D11.2a.1
symbol: hbl-1
gene_biotype: protein_coding
description:
  Hunchback-like protein; Required for the late stages of development. Plays a role in the developmental timing of postembryonic hypodermal seam cell fusion events and adult alae production.


ensembl_gene_id: F13D12.4a.3
symbol: alh-8
gene_biotype: protein_coding
description:
  Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial; Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA (By similarity); Belongs to the aldehyde dehydrogenase family.


ensembl_gene_id: F13D12.7a.1
symbol: gpb-1
gene_biotype: protein_coding
description:
  Guanine nucleotide-binding protein subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. In the early embryo, controls the magnitude of the forces acting on centrosomes but is not required for generating asymmetric forces.


ensembl_gene_id: F13G3.5a.3
symbol: ttx-7
gene_biotype: protein_coding
description:
  Inositol monophosphatase ttx-7; Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides. Has broad substrate specificity and can use myo-inositol monophosphates, myo- inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo- inositol-phosphate, D-galactose 1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates (By similarity). Required in central interneurons of the mature nervous system for correct localization of synaptic components. Required for ther [...]


ensembl_gene_id: F13G3.8.2
symbol: eat-5
gene_biotype: protein_coding
description:
  Innexin eat-5; Structural component of the gap junctions (By similarity). Required for synchronized pharyngeal muscle contractions. Belongs to the pannexin family.


ensembl_gene_id: F13H10.3b.1
symbol: F13H10.3
gene_biotype: protein_coding
description:
  Sodium-coupled neutral amino acid transporter 9 homolog; Lysosomal amino acid transporter involved in the activation of mTORC1 in response to amino acid levels. Probably acts as an amino acid sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids.


ensembl_gene_id: F13H10.4a.1
symbol: mogs-1
gene_biotype: protein_coding
description:
  Mannosyl-oligosaccharide glucosidase; Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor highly specifically.


ensembl_gene_id: F14B8.2.1
symbol: sid-5
gene_biotype: protein_coding
description:
  Systemic RNA interference defective protein 5; Plays a role in RNA-mediated gene silencing by mediating transport of both ingested and endogenous dsRNA between cells. Not required for the uptake of dsRNA from the intestinal lumen.


ensembl_gene_id: F14D12.2.1
symbol: unc-97
gene_biotype: protein_coding
description:
  LIM domain-containing protein unc-97; Component of an integrin containing attachment complex, which is required for muscle development and maintenance. Probably function in adherens junction. Affects the structural integrity of the integrin containing muscle adherens junctions and contributes to the mechanosensory functions of touch neurons.


ensembl_gene_id: F14D12.4e.1
symbol: mec-2
gene_biotype: protein_coding
description:
  Mechanosensory protein 2; Positively regulates the activity of the putative mechanosensory transduction channel. May link the mechanosensory channel and the microtubule cytoskeleton of the touch receptor neurons. Required for the function of a set of six touch receptor neurons.


ensembl_gene_id: F14F3.3.1
symbol: mboa-7
gene_biotype: protein_coding
description:
  Lysophospholipid acyltransferase 7; Acyltransferase which mediates the conversion of lysophosphatidylinositol (1-acyl-sn-glycero-3-phosphatidylinositol or LPI) into phosphatidylinositol (1,2-diacyl-sn-glycero-3-phosphoinositol or PI) (LPIAT activity). Prefers arachidonoyl-CoA or eicosapentaenoic acid (EPA) as the acyl donor. Prefers sn-2-LPI rather than sn-1-LPI as the acyl acceptor. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle.


ensembl_gene_id: F14F4.1.1
symbol: ntr-2
gene_biotype: protein_coding
description:
  Nematocin receptor 2; Not directly activated by nematocin. May modulate activity of the nematocin receptor ntr- 1, leading to reduced intracellular cAMP production. Plays a role in male mating behavior. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.


ensembl_gene_id: F14H12.4b.1
symbol: cst-1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase cst-1 18kDa subunit; Serine/threonine-protein kinase which extends lifespan and delays tissue aging, probably by activating daf-16.


ensembl_gene_id: F15A2.6a.1
symbol: sad-1
gene_biotype: protein_coding
description:
  Serine/threonine kinase SAD-1; Regulates both neuronal polarity and synaptic organization when bound to strd-1. Kinase activity is required for the establishment, but not the maintenance, of both processes. Binding to nab-1 is essential for role in restricting axonal fate during neuronal polarization but is not required for regulating synapse morphology.


ensembl_gene_id: F15C11.2a.1
symbol: ubql-1
gene_biotype: protein_coding
description:
  Ubiquilin; May play a role in the ER-associated protein degradation pathway (ERAD) possibly via its interaction with ER-localized proteins ubxn-4 and cdc-48.1 and/or cdc48.2, providing a link between the polyubiquitinated ERAD substrates and the proteasome. Also plays an important role in the regulation of other protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS) and autophagy (By similarity). Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by intera [...]


ensembl_gene_id: F15D3.1a.1
symbol: dys-1
gene_biotype: protein_coding
description:
  Dystrophin-1; Plays a role in cholinergic transmission and as a functional partner of dystrobrevin (dyb-1), necessary for muscle maintenance. Required for neuronal positioning.


ensembl_gene_id: F15D4.8.1
symbol: flp-16
gene_biotype: protein_coding
description:
  FMRFamide-like neuropeptides 16; FMRFamides and FMRFamide-like peptides are neuropeptides. AQTFVRF-amide inhibits the activity of dissected pharyngeal myogenic muscle system.


ensembl_gene_id: F15E6.1.1
symbol: set-9
gene_biotype: protein_coding
description:
  Histone-lysine N-methyltransferase set-9; Histone methyltransferase (By similarity). Might play a role in transcriptional regulation. Together with set-26, negatively regulates lifespan in a germline-independent, partially daf- 16-dependent fashion. Together with set-26, plays a role in germline development and maintenance and might play a role in the restriction of the trimethylation mark on histone H3 'Lys-4'(H3K4me3) to target genes specifically in the germline ; Belongs to the class V-like SAM-binding methyltransferase superfamily.


ensembl_gene_id: F15H10.1.1
symbol: col-12
gene_biotype: protein_coding
description:
  Cuticle collagen 12; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.


ensembl_gene_id: F15H10.2.1
symbol: col-13
gene_biotype: protein_coding
description:
  Cuticle collagen 13; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.


ensembl_gene_id: F15H10.3d.1
symbol: apc-10
gene_biotype: protein_coding
description:
  Anaphase-promoting complex subunit 10; Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins.


ensembl_gene_id: F16A11.2a.1
symbol: rtcb-1
gene_biotype: protein_coding
description:
  RNA-splicing ligase RtcB homolog; Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs. Required for the ligation of mRNAs and specifically, regulates xbp-1 mRNA splicing during the endoplasmic reticulum stress- induced unfolded protein response. Has a neuroprotective role in the age-dependent degeneration of dopamine neurons, which is mediated by xbp-1. Belongs to the RtcB family.


ensembl_gene_id: F16A11.3d.1
symbol: ppfr-1
gene_biotype: protein_coding
description:
  Serine/threonine-protein phosphatase 4 regulatory subunit 1; Probable regulatory subunit of serine/threonine-protein phosphatase PP4 which may play a role in meiosis and embryonic mitosis. Probably in association with catalytic subunit pph-4.1, regulates microtubule severing during oocyte meiosis II by dephosphorylating and likely activating mei-1, a component of the katanin microtubule severing complex.


ensembl_gene_id: F16B4.8a.1
symbol: cdc-25.2
gene_biotype: protein_coding
description:
  M-phase inducer phosphatase cdc-25.2; Required for intestinal cell division following the 16E cell stage of embryogenesis. Regulates intestinal cell divisions and binucleations probably by modulating the activity of the cell cycle regulator wee-1.3 and by activating the cdk-1/cyb-1 complex. Belongs to the MPI phosphatase family.


ensembl_gene_id: F16D3.1.1
symbol: tba-5
gene_biotype: protein_coding
description:
  Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family.


ensembl_gene_id: F16D3.4.1
symbol: tbcd-1
gene_biotype: protein_coding
description:
  Tubulin-specific chaperone D; Tubulin-folding protein; involved in the first step of the tubulin folding pathway (By similarity). Plays a role in microtubule polymerization ; Belongs to the TBCD family.


ensembl_gene_id: F16F9.5.1
symbol: mec-10
gene_biotype: protein_coding
description:
  Degenerin mec-10; Amiloride-sensitive sodium channel subunit required for mechanosensory transduction (touch sensitivity). Negatively regulates the turning step of male mating behavior.


ensembl_gene_id: F16H9.1b.1
symbol: rgs-2
gene_biotype: protein_coding
description:
  Regulator of G-protein signaling rgs-2; Weakly inhibits G protein signaling in nervous system, interacting preferentially with the G(O) subfamily member goa-1. In vitro, it acts as a GTPase activator of goa-1. Rgs-1 and rgs-2 redundantly adjust signaling when worms are fed to allow rapid induction of egg-laying behavior. Modulates chemotaxis responses by regulating negatively the sensitivity to quinine in ASH sensory neurons.


ensembl_gene_id: F17C11.9a.1
symbol: eef-1G
gene_biotype: protein_coding
description:
  Probable elongation factor 1-gamma; Probably plays a role in anchoring the complex to other cellular components.


ensembl_gene_id: F17E5.1a.1
symbol: lin-2
gene_biotype: protein_coding
description:
  Protein lin-2; May play a structural role in the induction of the vulva. May be required for the localization of signal transduction molecules (such as let-23 receptor) to either the basal membrane domain or the cell junctions.


ensembl_gene_id: F17E5.2.1
symbol: F17E5.2
gene_biotype: protein_coding
description:
  Probable calcium-binding mitochondrial carrier F17E5.2; Calcium-dependent mitochondrial solute carrier. Belongs to the mitochondrial carrier (TC 2.A.29) family.


ensembl_gene_id: F17H10.3a.1
symbol: snx-17
gene_biotype: protein_coding
description:
  Sorting nexin-17 homolog; Critical regulator of endosomal recycling of numerous receptors, channels, and other transmembrane proteins. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)).


ensembl_gene_id: F18A1.2d.1
symbol: lin-26
gene_biotype: protein_coding
description:
  Transcription factor lin-26; Presumed to be a transcription factor required to specify the fates of hypodermal and neuron-associated support cells. Functions during vulval development, playing a role in vulval precursor cell fate specification.


ensembl_gene_id: F18A1.5.1
symbol: rpa-1
gene_biotype: protein_coding
description:
  Probable replication factor A 73 kDa subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.


ensembl_gene_id: F18A1.8.1
symbol: pid-1
gene_biotype: protein_coding
description:
  21U-RNA biogenesis factor pid-1; Plays a role in the biogenesis of 21U-RNAs which guide the piwi protein prg-1 to its DNA targets for silencing.


ensembl_gene_id: F18A11.1.2
symbol: puf-6
gene_biotype: protein_coding
description:
  Pumilio domain-containing protein 6; RNA-binding protein that binds to the consensus sequence 5'- CUCUGUAUCUUGU-3' in mRNA 3'-UTRs and modulates mRNA expression and stability. Functions redundantly with puf-5 and puf-7 in oocyte formation and organization, early embryonic cell divisions, and repression of expression of glp-1 and other maternal mRNAs in late oogenesis.


ensembl_gene_id: F18C12.1.1
symbol: che-3
gene_biotype: protein_coding
description:
  Cytoplasmic dynein 2 heavy chain 1; Functions as a motor for intraflagellar retrograde transport in chemosensory neurons. Functions in cilia biogenesis. Belongs to the dynein heavy chain family.


ensembl_gene_id: F18C5.2.1
symbol: wrn-1
gene_biotype: protein_coding
description:
  Probable Werner syndrome ATP-dependent helicase homolog 1; Essential for the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity. May be involved in the control of genomic stability (By similarity).


ensembl_gene_id: F18E2.3.1
symbol: scc-3
gene_biotype: protein_coding
description:
  Cohesin subunit scc-3; Component of the cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped (By similarity). At anaphase, the scc-1 subunit of the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate (By similarity). The cohesin complex may also play a role in spindle pole assembly during mitosis (By similarity). Has a role in stabilization of homologous chromosome associations during meiotic syn [...]


ensembl_gene_id: F18E2.5b.1
symbol: gpa-13
gene_biotype: protein_coding
description:
  Guanine nucleotide-binding protein alpha-13 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.


ensembl_gene_id: F18E3.7a.2
symbol: ddo-2
gene_biotype: protein_coding
description:
  D-aspartate oxidase 2; Selectively catalyzes the oxidative deamination of D- aspartate and its N-methylated derivative, N-methyl D-aspartate. Highest catalytic efficiency for D-Glu followed by D-Asp and NMDA. May play a role in the egg-laying events and early development of the worm, in addition to quality control of the germ cells.


ensembl_gene_id: F18E9.2a.1
symbol: nlp-7
gene_biotype: protein_coding
description:
  Neuropeptide-like protein 7; May regulate lifespan in response to food availability and oxidative stress.


ensembl_gene_id: F18E9.5b.1
symbol: jmjd-3.1
gene_biotype: protein_coding
description:
  Lysine-specific demethylase jmjd-3.1; Histone demethylase that specifically demethylates trimethylated 'Lys-27' of histone H3, a mark associated with transcriptional repression, thereby playing a central role in the histone code. Involved in the transcriptional regulation of the heat shock response, unfolded protein response and possibly other stress response target genes. Required for gonad development and organization. Required for the robust transdifferentiation of the Y rectal epithelial cell to the PDA motor neuron during larval development. Acts cell- autonomously in Y-to-PDA tra [...]


ensembl_gene_id: F18F11.5.1
symbol: drl-1
gene_biotype: protein_coding
description:
  Protein drl-1; Negatively regulates lifespan and health span probably by participating in nutrient sensing.


ensembl_gene_id: F18G5.3.1
symbol: gpa-12
gene_biotype: protein_coding
description:
  Guanine nucleotide-binding protein alpha-12 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (Probable). May play a role in resistance to fungal infection in the epidermis by regulating the up-regulation of several antimicrobial peptides of the NLP and CNC families. Upstream of plc-3, tpa-1 and the p38-like pathway, required for the expression of antimicrobial peptide nlp-29 in the epidermis in response to fungal infection or physical injury.


ensembl_gene_id: F18G5.4.1
symbol: lgc-4
gene_biotype: protein_coding
description:
  Ligand-gated ion channel 4; Possible acetylcholine receptor; Belongs to the ligand-gated ion channel (TC 1.A.9) family.


ensembl_gene_id: F18H3.3a.1
symbol: pab-2
gene_biotype: protein_coding
description:
  Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family.


ensembl_gene_id: F18H3.5b.1
symbol: cdk-4
gene_biotype: protein_coding
description:
  Cyclin-dependent kinase 4 homolog; Serine/threonine-protein kinase which, in association with cyclin D-like protein cyd-1, is required for the progression through the G1 phase of the cell cycle during postembryonic development by phosphorylating and inhibiting lin-35 and fzr-1. In complex with cyd-1, involved in sex determination during gonadogenesis by regulating the asymmetric division of the somatic gonadal precursor cell (SGP).


ensembl_gene_id: F19B10.9.1
symbol: sea-1
gene_biotype: protein_coding
description:
  T-box transcription factor 18; Probable transcriptional regulator involved in developmental processes. Activates xol-1 transcription, either directly or indirectly, establishing that xol-1 acts as the master regulator to integrate both X chromosome and autosomal signals to determine sexual fate.


ensembl_gene_id: F19B6.2a.2
symbol: ufd-1
gene_biotype: protein_coding
description:
  Ubiquitin fusion degradation protein 1 homolog; Functions at a post-ubiquitination step in the ubiquitin fusion degradation (UFD) pathway (By similarity). In association with npl-4.1 and/or npl-4.2 and ATPase cdc-48.1 and/or cdc-48.2, involved in the cytoplasmic elimination of misfolded proteins exported from the ER. This pathway, known as ERAD, prevents the activation of the unfolded protein response (UPR) caused by the accumulation of misfolded proteins in the ER. During S phase and in association with npl-4.1 and/or npl-4.2, cdc-48.1 and/or cdc-48.2 and ubxn-3, ensures the degradati [...]


ensembl_gene_id: F19C6.1.1
symbol: grk-1
gene_biotype: protein_coding
description:
  G protein-coupled receptor kinase 1; Specifically phosphorylates the activated forms of G protein- coupled receptors; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.


ensembl_gene_id: F19H6.1.2
symbol: nekl-3
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase nekl-3; Probable serine/threonine-protein kinase required for the completion of molting; Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.


ensembl_gene_id: F19H6.4.1
symbol: F19H6.4
gene_biotype: protein_coding
description:
  3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology.


ensembl_gene_id: F19H8.1a.1
symbol: tps-2
gene_biotype: protein_coding
description:
  Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 2; Catalyzes the production of trehalose from glucose-6- phosphate and UDP-alpha-D-glucose in a 2 step process; In the N-terminal section; belongs to the glycosyltransferase 20 family.


ensembl_gene_id: F19H8.3.1
symbol: arl-3
gene_biotype: protein_coding
description:
  ADP-ribosylation factor-like protein 3; GTP-binding protein that may be involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.


ensembl_gene_id: F20B4.6.1
symbol: cgt-2
gene_biotype: protein_coding
description:
  Ceramide glucosyltransferase 2; Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide. Belongs to the glycosyltransferase 2 family.


ensembl_gene_id: F20B6.2.1
symbol: vha-12
gene_biotype: protein_coding
description:
  Probable V-type proton ATPase subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells (By similarity). Required for necrotic cell death and epidermal cell fusion.


ensembl_gene_id: F20B6.8b.1
symbol: hpk-1
gene_biotype: protein_coding
description:
  Homeodomain-interacting protein kinase 1; Serine/threonine-protein kinase required in the somatic gonadal cells to regulate germline proliferation during larval development and in adulthood. Plays a role in the development/differentiation of gonadal distal tip cells. Required for normal lifespan in a pha-4 and mxl-2- dependent manner. Also contributes to survival following heat or oxidative stress. Prevents sumoylation and inactivation of heat shock transcription factor hsf-1 which enhances hsf-1-dependent transcriptional induction of chaperones in response to heat shock. Also required [...]


ensembl_gene_id: F20C5.1i.1
symbol: parg-1
gene_biotype: protein_coding
description:
  Poly(ADP-ribose) glycohydrolase 1; Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. Poly(ADP-ribose) metabolism may be required for maintenance of the normal function of neuronal cells (By similarity).


ensembl_gene_id: F20C5.2a.1
symbol: klp-11
gene_biotype: protein_coding
description:
  Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.


ensembl_gene_id: F20C5.3b.1
symbol: elli-1
gene_biotype: protein_coding
description:
  Enlarged germline granules protein 1; Plays a role in modulating RNAi activity and P-granule accumulation in the germline. May function in association with CSR-1 complex components such as drh-3 to regulate RNA transcript accumulation in germ cells.


ensembl_gene_id: F20D1.10.3
symbol: emre-1
gene_biotype: protein_coding
description:
  Essential MCU regulator, mitochondrial; Essential regulatory subunit of the mitochondrial calcium uniporter (mcu-1) channel, a protein that mediates calcium uptake into mitochondria; Belongs to the SMDT1/EMRE family.


ensembl_gene_id: F20D1.6.1
symbol: rbg-1
gene_biotype: protein_coding
description:
  Rab3 GTPase-activating protein catalytic subunit; Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily. Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Specifically converts active Rab3-GTP to the inactive form Rab3-GDP (By similarity).


ensembl_gene_id: F20D12.3.1
symbol: bbs-2
gene_biotype: protein_coding
description:
  Bardet-Biedl syndrome 2 protein homolog; Component of the BBSome complex (By similarity). The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function (By similarity). Required for proper BBSome complex assembly and its ciliary localization. Required for cilia biogenesis and both the assembly and movement of intraflagellar transport proteins along the ciliary axoneme.


ensembl_gene_id: F20D12.4.2
symbol: czw-1
gene_biotype: protein_coding
description:
  Centromere/kinetochore protein zw10 homolog; Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and mdf-1-mdf-2 complexes onto kinetochores. Its function related to the spindle assembly machinery and kinetochore-microtubule attachments likely depends on its association in the mitotic RZZ complex. The RZZ complex recruits the spindly-like protein spdl-1 to kinetochores. To prevent irregular chromosome segregation, the complex also inhibits the attachment of the kinetochore-associated NDC8 [...]


ensembl_gene_id: F20H11.2.1
symbol: let-765
gene_biotype: protein_coding
description:
  Protein strawberry notch homolog; Transcriptional activator that functions upstream of the let- 60/Ras and let-23/EGFR signaling pathways to positively regulate lin-3 expression and thereby promote vulval induction. Plays a role in excretory duct development. Plays a role in male tail development.


ensembl_gene_id: F20H11.5.1
symbol: ddo-3
gene_biotype: protein_coding
description:
  D-aspartate oxidase 3; Selectively catalyzes the oxidative deamination of D- aspartate and its N-methylated derivative, N-methyl D-aspartate. Has no activity towards L-amino acids or N-methyl-L-aspartic acid. May play a role in the egg-laying events and maturation processes of the reproductive organs.


ensembl_gene_id: F21A10.2e.1
symbol: myrf-2
gene_biotype: protein_coding
description:
  Myelin regulatory factor homolog 2, C-terminal; [Myelin regulatory factor homolog 2]: Constitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor homolog 2, N-terminal component that specifically activates transcription of genes involved in synaptic rewiring during nervous system maturation. [Myelin regulatory factor homolog 2, N-terminal]: Transcription factor that specifically activates expression of genes involved in synaptic rewiring during nervous system maturation. Specifically required for dorsal D (DD) GABA [...]


ensembl_gene_id: F21A3.5.1
symbol: prde-1
gene_biotype: protein_coding
description:
  piRNA biogenesis factor prde-1; Nuclear factor required for the production of piwi- interacting RNA (piRNA) precursors. Specifically required for piRNAs produced from loci associated with the Ruby motif. Promotes binding of the transcription factor snpc-4 at piRNA genomic clusters. Required for normal fertility.


ensembl_gene_id: F21A3.7a.1
symbol: lgc-31
gene_biotype: protein_coding
description:
  Neur_chan_memb domain-containing protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family.


ensembl_gene_id: F21C3.5.1
symbol: pfd-6
gene_biotype: protein_coding
description:
  Probable prefoldin subunit 6; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity). Required for positioning of the mitotic spindle.


ensembl_gene_id: F21D5.1.1
symbol: F21D5.1
gene_biotype: protein_coding
description:
  Phosphoacetylglucosamine mutase; Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O- glycosylation; Belongs to the phosphohexose mutase family.


ensembl_gene_id: F21D5.7.1
symbol: F21D5.7
gene_biotype: protein_coding
description:
  Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). Belongs to the GTP-binding SRP family. SRP54 subfamily.


ensembl_gene_id: F21F3.1.1
symbol: pgal-1
gene_biotype: protein_coding
description:
  Probable peptidyl-alpha-hydroxyglycine alpha-amidating lyase pgal-1; Probable lyase that catalyzes an essential reaction in C- terminal alpha-amidation of peptides. Mediates the dismutation of the unstable peptidyl(2-hydroxyglycine) intermediate to glyoxylate and the corresponding desglycine peptide amide. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity (By similarity).


ensembl_gene_id: F21F3.5.1
symbol: unc-38
gene_biotype: protein_coding
description:
  Acetylcholine receptor subunit alpha-type unc-38; Alpha subunit of nicotinic acetylcholine receptor (nAChR). Probably acts in cholinergic motoneurons to regulate presynaptic neurotransmitter release, thereby ensuring normal level of excitation of cholinergic motoneurons during locomotion. Involved in nAChR sensitivity to nicotine. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.


ensembl_gene_id: F21H12.1.1
symbol: rbbp-5
gene_biotype: protein_coding
description:
  Retinoblastoma-binding protein homolog 5; Required for di- and trimethylation at 'Lys-4' of histone H3.


ensembl_gene_id: F21H12.5.1
symbol: fbf-2
gene_biotype: protein_coding
description:
  Fem-3 mRNA-binding factor 2; Involved in the control of stem cells and sex determination in the C.elegans hermaphrodite germline. May also play a role in the hermaphrodite germline proliferation and oogenesis. By binding to the 3'-UTR, represses phosphatase lip-1 expression in the distal part of the germline mitotic zone. Binds specifically to the regulatory region of fem-3 3'-UTR and mediates the sperm/oocyte switch. Negatively regulates gld-3 expression possibly by directly binding to two sites within the gld-3 isoform b 3'-UTR. Suppresses germline tumor formation by preventing the d [...]


ensembl_gene_id: F21H12.6.1
symbol: tpp-2
gene_biotype: protein_coding
description:
  Tripeptidyl-peptidase 2; Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter is inhibited (By similarity). Has a role in regulation of fat storage; Belongs to the peptidase S8 family.


ensembl_gene_id: F21H7.9.1
symbol: gcy-20
gene_biotype: protein_coding
description:
  Receptor-type guanylate cyclase gcy-20; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity).


ensembl_gene_id: F22A3.1b.1
symbol: ets-4
gene_biotype: protein_coding
description:
  Transcription factor ets-4; Transcription factor which binds to 5'-GGAA/T-3' DNA consensus sequences. Both positively and negatively regulates the expression of target genes. Plays a role in the regulation of adult lifespan, which may in part be through modulation of daf-16 activity. Regulates the expression of genes such as svh-2 in response to axon injury and in addition, may function downstream of the cAMP signaling pathway to promote axon regeneration. Regulates the expression of lipid metabolism genes and may also control the expression of the RNA-binding protein rege-1 which too  [...]


ensembl_gene_id: F22B5.1.1
symbol: evl-20
gene_biotype: protein_coding
description:
  ADP-ribosylation factor-like protein 2; GTP-binding protein that functions in embryogenesis, cytokinesis, germline development and microtubulule cytoskeleton dynamics.


ensembl_gene_id: F22B5.10.1
symbol: F22B5.10
gene_biotype: protein_coding
description:
  Calcium load-activated calcium channel homolog; Calcium-selective channel required to prevent calcium stores from overfilling.


ensembl_gene_id: F22B5.2a.1
symbol: eif-3.G
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 3 subunit G; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA.


ensembl_gene_id: F22B5.7.1
symbol: zyg-9
gene_biotype: protein_coding
description:
  Zygote defective protein 9; Plays a major role in organizing microtubules and spindle poles during mitosis and meiosis in one-cell stage embryos. Required for default nucleus positioning in oocytes.


ensembl_gene_id: F22B7.10.1
symbol: dpy-19
gene_biotype: protein_coding
description:
  C-mannosyltransferase dpy-19; C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins such as unc-5 and mig-21. Mediates the attachment of alpha-mannose in C-C linkage to the C2 of the indole ring of tryptophan. C-mannosylation takes place in the endoplasmic reticulum and frequently found in thrombospondin (TSP) type-1 repeats and in the WSXWS motif of type I cytokine receptors. Required to orient neuroblasts QL and QR correctly on the anterior/posterior (A/P) axis: QL and QR are born in the same A/P position, but polarize and migrate left/right as [...]


ensembl_gene_id: F22B7.13.1
symbol: gpr-1
gene_biotype: protein_coding
description:
  G-protein regulator 1; In the 1-cell embryo, probably together with gpr-2, controls nuclear rotation and spindle elongation during mitosis. Complex of gpr-1 and gpr-2, in association with lin- 5, activates G-protein signaling to affect mitotic spindle force. Polarity determinants (par genes) may regulate lin- 5/gpr-1/gpr-2/goa-1 locally to create the asymmetric forces that drive spindle movement.


ensembl_gene_id: F22B7.6a.1
symbol: polk-1
gene_biotype: protein_coding
description:
  DNA polymerase kappa; DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3'-5' proofreading exonuclease activity. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity (By similarity). Belongs to the DNA polymerase type-Y family.


ensembl_gene_id: F22D3.1d.2
symbol: ceh-38
gene_biotype: protein_coding
description:
  Homeobox protein ceh-38; Probable DNA-binding regulatory protein involved in cell-fate specification.


ensembl_gene_id: F22D6.3a.1
symbol: nars-1
gene_biotype: protein_coding
description:
  Asparagine--tRNA ligase, cytoplasmic; Involved in protein synthesis. Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Belongs to the class-II aminoacyl-tRNA synthetase family.


ensembl_gene_id: F22D6.4.2
symbol: nduf-6
gene_biotype: protein_coding
description:
  Probable NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).


ensembl_gene_id: F22E10.5a.1
symbol: cept-1
gene_biotype: protein_coding
description:
  Choline/EthanolaminePhosphoTransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.


ensembl_gene_id: F22E12.4a.2
symbol: egl-9
gene_biotype: protein_coding
description:
  Hypoxia-inducible factor prolyl hydroxylase; Cellular oxygen sensor which regulates the stability and the activity of hypoxia-inducible transcription factor, hif-1. In normoxic conditions, hydroxylates hif-1 targeting it for vhl-1-mediated proteasomal degradation. In addition, regulates hif-1 transcriptional activity in a vhl-1-independent manner and independently of its hydroxylase activity. By regulating hif-1 activity, controls several cellular responses. Mediates susceptibility to B.thuringiensis and V.cholerae pore-forming toxins and enteropathogenic E.coli. Mediates susceptibilit [...]


ensembl_gene_id: F22E5.3.1
symbol: gcy-21
gene_biotype: protein_coding
description:
  Receptor-type guanylate cyclase gcy-21; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity).


