# geneInfo

ensembl_gene_id: T01C2.1.1
symbol: acy-4
gene_biotype: protein_coding
description:
  Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.


ensembl_gene_id: T01C3.2.1
symbol: T01C3.2
gene_biotype: protein_coding
description:
  Transcription and mRNA export factor ENY2; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates histones. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. The TREX-2 complex  [...]


ensembl_gene_id: T01C3.7.2
symbol: fib-1
gene_biotype: protein_coding
description:
  rRNA 2'-O-methyltransferase fibrillarin; S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins (By similarity). Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl- L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA (By similarity). Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA (By similarity). Also acts as a protein  [...]


ensembl_gene_id: T01C3.9.1
symbol: hrde-2
gene_biotype: protein_coding
description:
  Protein hrde-2; Plays a role in germline RNA interference (RNAi), and in particular is required for piwi-interacting RNA (piRNA) gene silencing. Facilitates the binding of the argonaut protein hrde-1 to small interfering RNAs (siRNAs) targets that are required for transgenerational epigenetic inheritance and germline immortality.


ensembl_gene_id: T01C8.1b.1
symbol: aak-2
gene_biotype: protein_coding
description:
  5'-AMP-activated protein kinase catalytic subunit alpha-2; Acts as a sensor that couples lifespan to information about energy levels and insulin-like signals. Role in motility and response to oxidative stress. Involved in the establishment of germline stem cell (GSC) quiescence during dauer development. Plays a role in axon regrowth after axotomy in PLM neurons. Plays a role in the maintenance of glycogen stores which are necessary for resistance to hyperosmotic stress. Plays a role in the regulation of flp-7 secretion from ASI neurons. Keeps the CREB-regulated transcription coactivato [...]


ensembl_gene_id: T01C8.5.1
symbol: got-1.2
gene_biotype: protein_coding
description:
  Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the central nervous system.


ensembl_gene_id: T01C8.7.2
symbol: mec-4
gene_biotype: protein_coding
description:
  Degenerin mec-4; Probable sodium channel subunit. May be needed for mechanosensory transduction (touch sensitivity). Negatively regulates the turning step of male mating behavior.


ensembl_gene_id: T01D1.4a.1
symbol: T01D1.4
gene_biotype: protein_coding
description:
  1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase homolog 1; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene); Belongs to the acireductone dioxygenase (ARD) family.


ensembl_gene_id: T01D3.2.1
symbol: hlh-34
gene_biotype: protein_coding
description:
  Helix-loop-helix 34; Transcription factor that may be a master gene of CNS development in cooperation with Arnt. It may have pleiotropic effects in the tissues expressed during development (By similarity).


ensembl_gene_id: T01E8.3.1
symbol: plc-3
gene_biotype: protein_coding
description:
  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma plc-3; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) which plays an important role in the regulation of intracellular signaling cascades (Probable). Regulates basal and ovulatory sheath cell contractions by controlling Ca(2+) oscillations via IP3-mediated activation of IP3 receptor itr-1. In intestinal epithelial cells, regulates Ca(2+) oscillations which control posterior body wall muscle contractions required for defecation by IP3-mediated activation [...]


ensembl_gene_id: T01E8.4.1
symbol: mec-15
gene_biotype: protein_coding
description:
  F-box/WD repeat-containing protein mec-15; Plays a role in mechanosensory transduction (touch sensitivity), touch receptor neuron development and synapse formation. Regulates expression of the protein snb-1 and the distribution of synaptic vesicles at synapses to promote synaptic transmission at the neuromuscular junctions of GABAergic motor neurons.


ensembl_gene_id: T01E8.5.1
symbol: nrde-2
gene_biotype: protein_coding
description:
  Nuclear exosome regulator NRDE2; Protein of the nuclear speckles that regulates RNA exosomal degradation (By similarity). Involved in short interfering RNAs- mediated silencing in nuclei. Functions with nrde-3 in the nuclear RNA-mediated gene silencing (RNAi) pathway to regulate gene expression via inhibition of RNA polymerase II during the elongation phase of transcription. Required for exogenous RNAi-induced H3K27 methylation. Belongs to the NRDE2 family.


ensembl_gene_id: T01E8.6.1
symbol: mrps-14
gene_biotype: protein_coding
description:
  Probable 40S ribosomal protein S14, mitochondrial; Belongs to the universal ribosomal protein uS14 family.


ensembl_gene_id: T01E8.9.1
symbol: ubxn-5
gene_biotype: protein_coding
description:
  UBX domain-containing protein 5; Probably acts as an adapter for ATPase cdc-48.1 and/or cdc- 48.2, conferring substrate specificity. Unlike other UBX domain- containing protein does not bind 'Lys-48'-polyubiquitinated chain.


ensembl_gene_id: T01G6.4.1
symbol: nhr-106
gene_biotype: protein_coding
description:
  Nuclear hormone receptor family member nhr-106; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family.


ensembl_gene_id: T01G6.7.1
symbol: nhr-55
gene_biotype: protein_coding
description:
  Nuclear hormone receptor family member nhr-55; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family.


ensembl_gene_id: T01G6.8.2
symbol: nhr-130
gene_biotype: protein_coding
description:
  Nuclear hormone receptor family member nhr-130; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family.


ensembl_gene_id: T01G9.5b.1
symbol: mei-1
gene_biotype: protein_coding
description:
  Meiotic spindle formation protein mei-1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays. Required specifically for meiotic spindle formation in the female germline; the presence of this protein is inimical to the formation of mitotic spindles. In body wall muscles, regulates organization of myosin thick filaments.


ensembl_gene_id: T01G9.6b.2
symbol: kin-10
gene_biotype: protein_coding
description:
  Casein kinase II subunit beta; Participates in Wnt signaling. Plays a complex role in regulating the basal catalytic activity of the alpha subunit (By similarity). Modulates two aspects of male mating behavior; response to hermaphrodite contact and vulval location, acting in the same pathway as lov-1 and pkd-2; Belongs to the casein kinase 2 subunit beta family.


ensembl_gene_id: T01H8.1e.1
symbol: rskn-1
gene_biotype: protein_coding
description:
  Putative ribosomal protein S6 kinase alpha-1; Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of transcription (By similarity). Suppresses germline tumor formation by preventing the dedifferentiation of secondary spermatocytes probably downstream of mpk-1 ; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.


ensembl_gene_id: T01H8.5a.1
symbol: gon-2
gene_biotype: protein_coding
description:
  Transient receptor potential channel; Required for initiation and continuation of postembryonic mitotic cell divisions of gonadal cells Z1 and Z4. Zygotic expression is necessary for hermaphrodite fertility. May be a cation channel. Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily.


ensembl_gene_id: T02E1.5b.1
symbol: dhs-3
gene_biotype: protein_coding
description:
  Protein dhs-3; May play a role in lipid droplet formation. May modulate triglyceride levels; Belongs to the short-chain dehydrogenases/reductases (SDR) family.


ensembl_gene_id: T02G5.13a.1
symbol: mmaa-1
gene_biotype: protein_coding
description:
  Methylmalonic aciduria type A homolog, mitochondrial; May have GTPase activity. May also bind and hydrolyze ATP. May function as chaperone (By similarity). Likely to have a role in propionyl-CoA metabolism and adenosylcobalamin synthesis.


ensembl_gene_id: T02G5.8.2
symbol: kat-1
gene_biotype: protein_coding
description:
  Acetyl-CoA acetyltransferase homolog, mitochondrial; Plays a role in ketone body metabolism (By similarity). Has an effect on lysosome related organelles (LRO) function, in a pathway with serotonin. Acts downstream of sir-2.1 to regulate aging and stress resistance. Belongs to the thiolase-like superfamily. Thiolase family.


ensembl_gene_id: T02G5.9b.1
symbol: kars-1
gene_biotype: protein_coding
description:
  Lysine--tRNA ligase; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA; Belongs to the class-II aminoacyl-tRNA synthetase family.


ensembl_gene_id: T03D8.1d.1
symbol: num-1
gene_biotype: protein_coding
description:
  Numb-related protein 1; Involved in the tethering and targeting of pkc-3 to modulate the intracellular distribution of the kinase. The complex formed with pkc-3 complexes are likely to be involved in assembly, maintenance, and/or regulation of protein complexes that execute asymmetric and/or polarized cell functions.


ensembl_gene_id: T03D8.5a.1
symbol: gcy-22
gene_biotype: protein_coding
description:
  Receptor-type guanylate cyclase gcy-22; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Regulates chemotaxis responses toward Li(1-), Mg(2+), Cl(1-), Br(1)- and I(1-) salt ions and methionine in ASE right (ASER) sensory neuron. May regulate ASER neuronal activity such as axon sprouting and calcium responses to changes in salt concentrations.


ensembl_gene_id: T03E6.7a.1
symbol: cpl-1
gene_biotype: protein_coding
description:
  Cathepsin L-like; Cysteine protease which plays an essential role in the degradation of proteins in lysosomes. During early embryogenesis, maternally required for the proteolytic processing of yolk proteins in platelets, a lysosome- like structure where a slow and controlled degradation of yolk proteins occurs. In the gonad, required for the clearance of apoptotic germ cells in the engulfing cell phagolysosomes. In embryos, required for the degradation of endocytic and autophagic cargos. In embryos, may play a role in the degradation of lipid-containing droplets. Required for larval de [...]


ensembl_gene_id: T03F1.1.2
symbol: uba-5
gene_biotype: protein_coding
description:
  Ubiquitin-like modifier-activating enzyme 5; E1-like enzyme which activates ufm-1. Required for interaction between ufm-1 and ufc-1; Belongs to the ubiquitin-activating E1 family. UBA5 subfamily.


ensembl_gene_id: T03F1.2.1
symbol: coq-4
gene_biotype: protein_coding
description:
  Ubiquinone biosynthesis protein coq-4, mitochondrial; Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides; Belongs to the COQ4 family.


ensembl_gene_id: T03F1.5.2
symbol: gsp-4
gene_biotype: protein_coding
description:
  Serine/threonine-protein phosphatase PP1-delta; Probable phosphatase which plays a redundant role with gsp-4 in spermatogenesis by regulating sister chromatid segregation during meiosis. In addition, involved in sperm motility by controlling the dynamic disassembly of major sperm proteins (MSP) in the spermatozoan pseudopodium.


ensembl_gene_id: T03F1.7.1
symbol: tfbm-1
gene_biotype: protein_coding
description:
  Dimethyladenosine transferase 1, mitochondrial; Probable S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA. Stimulates transcription independently of the methyltransferase activity (By similarity); Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. KsgA subfamily.


ensembl_gene_id: T03F6.5.1
symbol: lis-1
gene_biotype: protein_coding
description:
  Lissencephaly-1 homolog; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as nuclear migration during cell division. Part of a complex with nud-2, which is recruited to the nuclear envelope by unc-83, where, in turn, it recruits dynein to the nuclear surface and regulates nuclear migration in hypodermal precursor cells. Plays a role in GABAergic synaptic vesicle localization in [...]


ensembl_gene_id: T03G11.8.1
symbol: zig-6
gene_biotype: protein_coding
description:
  Zwei Ig domain protein zig-6; Probably not involved in maintaining the position of ASI and ASH head neuron cell bodies and ventral nerve cord axons of PVQ, PVP, RMEV, AVK and HSN neurons.


ensembl_gene_id: T04A11.6.1
symbol: him-6
gene_biotype: protein_coding
description:
  Bloom syndrome protein homolog; Participates in DNA replication and repair (By similarity). Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction (By similarity). Negatively regulates sister chromatid exchange (SCE) ; Belongs to the helicase family. RecQ subfamily.


ensembl_gene_id: T04A8.12.2
symbol: tag-189
gene_biotype: protein_coding
description:
  Post-GPI attachment to proteins factor 2; Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface (By similarity); Belongs to the PGAP2 family.


ensembl_gene_id: T04A8.14.1
symbol: emb-5
gene_biotype: protein_coding
description:
  Suppressor of Ty 6 homolog; May regulate transcriptional elongation by RNA polymerase II. Required for several aspects of morphogenesis of C.elegans, including regulation of division in the germline and gut and specification of ventral-uterine precursor cell fate; Belongs to the SPT6 family.


ensembl_gene_id: T04A8.5.1
symbol: ppat-1
gene_biotype: protein_coding
description:
  Amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.


ensembl_gene_id: T04B2.2a.1
symbol: frk-1
gene_biotype: protein_coding
description:
  Fer-related kinase 1; Non-receptor tyrosine-protein kinase which plays a role in morphogenesis by regulating the epidermal enclosure of the embryo, independently of its kinase activity. Prevents hyperactivation of the Wnt signaling pathway during endoderm development, probably by preventing hmp-2 nuclear translocation.


ensembl_gene_id: T04C10.1.1
symbol: mbk-1
gene_biotype: protein_coding
description:
  Dual specificity tyrosine-phosphorylation-regulated kinase mbk-1; Possible role in the function of olfactory neurons. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.


ensembl_gene_id: T04C12.4.2
symbol: act-3
gene_biotype: protein_coding
description:
  Actin-1; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.


ensembl_gene_id: T04C12.5.2
symbol: act-2
gene_biotype: protein_coding
description:
  Actin-2; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.


ensembl_gene_id: T04D1.3d.1
symbol: unc-57
gene_biotype: protein_coding
description:
  Endophilin-A homolog; Involved in synaptic vesicle (SV) recycling in neurons probably by regulating clathrin-mediated endocytosis. By controlling SV endocytosis, regulates the rate of excitatory postsynaptic currents (EPSCs) at neuromuscular junctions and thus locomotion. In a similar manner, involved in necrotic neuronal cell death induced by abnormal hyperactivation of ion channels. Plays a minor role in responses to mechanical stimuli. Plays a minor role in unc- 26/synaptojanin localization to synapses.


ensembl_gene_id: T04D3.3a.1
symbol: pde-1
gene_biotype: protein_coding
description:
  Probable 3',5'-cyclic phosphodiesterase pde-1; Redundantly with pde-5, plays a role in the AFD thermosensory neurons to regulate microvilli receptive ending morphology, possibly by regulating cGMP levels.


ensembl_gene_id: T04D3.4a.1
symbol: gcy-35
gene_biotype: protein_coding
description:
  Soluble guanylate cyclase gcy-35; Plays a central role in social feeding behavior and oxygen sensation by synthesizing 3',5'-cyclic guanosine monophosphate (cGMP) from GTP. Oxygen, which binds to its heme-binding sites, probably regulates social behavior by modulating its activity. cGMP is a common second messenger in sensory transduction and is implicated in oxygen sensation. Indeed, C.elegans exhibits a strong behavioral preference for 5-12% oxygen, avoiding higher and lower oxygen levels; a higher level of oxygen inducing a naturally polymorphic social feeding behavior. Involved in  [...]


ensembl_gene_id: T04H1.4b.2
symbol: rad-50
gene_biotype: protein_coding
description:
  DNA repair protein rad-50; Essential component of the MRN complex, a complex that possesses single-stranded DNA endonuclease and 3' to 5' exonuclease activities, and plays a central role in double-strand break (DSB) repair, chromosome morphogenesis, DNA repair and meiosis. In the complex, it mediates the ATP-binding and is probably required to bind DNA ends and hold them in close proximity.


ensembl_gene_id: T04H1.9.1
symbol: tbb-6
gene_biotype: protein_coding
description:
  Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family.


ensembl_gene_id: T05A6.1.1
symbol: cki-1
gene_biotype: protein_coding
description:
  Cyclin-dependent kinase inhibitor 1; Negative cell-cycle regulator that functions at the G1-to-S- phase transition. Required for suspension of the cell cycle in dauer larvae and starved L1 larvae. In vulval precursor cells (VPCs), a pathway of heterochronic genes acts via cki-1 to maintain VPCs in G1 during the L2 larval stage. Cul-2 may function in ubiquitin-mediated degradation by targeting cki-1 for degradation. Involved in distal tip cell development by repressing and modulating cye-1/cdk-2 activity levels in Z1.aa/Z4.pp and in Z1.ap/Z4.pa. Belongs to the CDI family.


ensembl_gene_id: T05A7.10.1
symbol: fut-5
gene_biotype: protein_coding
description:
  Alpha-(1,3)-fucosyltransferase fut-5; Catalyzes the addition of fucose in alpha 1-3 linkage to GalNAc-beta-1->4-GlcNAc-beta-1->3-Gal-beta-1->4-Glc (LDNT)acceptor. Unlike fut-1, does not add fucose to Man-alpha-1->3-(Man-alpha-1->6)- Man-beta-1->4-GlcNAc-beta-1->4-GlcNAc-beta-1-Asn (M3), Man-alpha-1->3- (Man-alpha-1->6)-Man-beta-1->4-GlcNAc-beta-1->4-(Fuc-alpha-1->6)- GlcNAc-beta-1-Asn (M3F6) or GlcNAc-beta-1->2-Man-alpha-1->3-(GlcNAc- beta-1->2-Man-alpha-1->6)-Man-beta-1-4-GlcNAc-beta-1->4-(Fuc-alpha- 1->6)-GlcNAc-beta-1-Asn (GnM3F6) acceptors.


ensembl_gene_id: T05A7.5.1
symbol: fut-6
gene_biotype: protein_coding
description:
  Alpha-(1,3)-fucosyltransferase fut-6; Involved in the fucosylation of N-glycans. Preferentially catalyzes the addition of fucose in alpha 1-3 linkage to the distal GlcNAc residue in N-glycans. Catalyzes the transfer of fucose to Gal-beta-1-4-GlcNAc-alpha-pNP (LN-pNP) and Gal- beta-1-4-GlcNAc-beta-1-3-Gal-beta-1-4-Glc (LNnT). Unlike alpha-(1,3)-fucosyltransferase fut-1, does not transfer fucose to Man-alpha-1-3-(Man-alpha-1-6)-Man-beta-1-4-GlcNAc-beta-1-4-GlcNAc- beta-1-Asn (M3), Man-alpha-1-3-(Man-alpha-1-6)-Man-beta-1-4-GlcNAc- beta-1-4-(Fuc-alpha-1-6)-GlcNAc-beta-1-Asn (M3F6) and Glc [...]


ensembl_gene_id: T05A8.4.1
symbol: nep-2
gene_biotype: protein_coding
description:
  Neprilysin-2; Required for olfactory plasticity, which is the change from positive chemotaxis to dispersal after prolonged exposure to an odorant. Thought to antagonise snet-1 by degrading excess snet-1 peptides and thus enabling olfactory plasticity.


ensembl_gene_id: T05B11.3.1
symbol: clic-1
gene_biotype: protein_coding
description:
  Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.


ensembl_gene_id: T05B4.2.1
symbol: nhr-57
gene_biotype: protein_coding
description:
  Nuclear hormone receptor family member nhr-57; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family.


ensembl_gene_id: T05C12.10.1
symbol: qua-1
gene_biotype: protein_coding
description:
  Protein qua-1; Required for cuticle shedding and normal alae morphology and localization, and subsequently larval development.


ensembl_gene_id: T05C12.3.1
symbol: decr-1.3
gene_biotype: protein_coding
description:
  Probable 2,4-dienoyl-CoA reductase 3; Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily.


ensembl_gene_id: T05C12.6a.1
symbol: mig-5
gene_biotype: protein_coding
description:
  Segment polarity protein dishevelled homolog mig-5; Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Functions redundantly with other dishevelled family members throughout development. During embryonic and larval development, controls cell migration and/or cell fate specification of hypodermal cells, hypodermal seam cells, vulval precursor cells and, through distal tip cell migration, somatic gonad precursor cells. In early embryos, regulates the orientation of the mitotic spindle of blastomeres and specifically, along with dsh-2, is required for the cor [...]


ensembl_gene_id: T05C12.7.1
symbol: cct-1
gene_biotype: protein_coding
description:
  T-complex protein 1 subunit alpha; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.


ensembl_gene_id: T05E11.3a.1
symbol: enpl-1
gene_biotype: protein_coding
description:
  Endoplasmin homolog; Molecular chaperone that functions in the processing and transport of secreted proteins; Belongs to the heat shock protein 90 family.


ensembl_gene_id: T05E11.4a.1
symbol: spo-11
gene_biotype: protein_coding
description:
  Meiotic recombination protein spo-11; Required for meiotic recombination. Mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination.


ensembl_gene_id: T05E11.5.1
symbol: imp-2
gene_biotype: protein_coding
description:
  Intramembrane protease 2; Acts as intramembrane protease (Probable). In larvae, required for the complete shedding of the cuticle during molting, possibly by regulating cholesterol uptake via lrp-1. Involved in embryonic and larval development ; Belongs to the peptidase A22B family.


ensembl_gene_id: T05E11.6.1
symbol: hpo-4
gene_biotype: protein_coding
description:
  Putative GPI-anchor transamidase; Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein (By similarity); Belongs to the peptidase C13 family.


ensembl_gene_id: T05F1.1b.1
symbol: nra-2
gene_biotype: protein_coding
description:
  Nicalin; Involved in the recognition and selection of protein complexes to exit the endoplasmic reticulum (ER). In muscles, regulates levamisole-sensitive nicotinic acetylcholine receptor (L-AChR) subunit composition, possibly by allowing only specific L-AChR subunit combinations to exit the ER. Specifically, may promote the inclusion of alpha subunits unc-38 and unc-29 into L-AChR. Regulates L- AChR sensitivity to agonists such as nicotine and levamisole at neuro- muscular junctions. In touch neurons, may prevent ER exit of incorrectly folded mec-4-mec-10 ion channel ; Belongs to the  [...]


ensembl_gene_id: T05G5.10a.1
symbol: iff-1
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 5A-1; mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis (By similarity). Required for mitotic germ cell proliferation, gametogenesis after entry into meiosis, and localization of the P granule component pgl-1 on P granules; Belongs to the eIF-5A family.


ensembl_gene_id: T05G5.2.1
symbol: hlh-4
gene_biotype: protein_coding
description:
  Helix-loop-helix protein 4; Acts as a transcriptional regulator. May mediate transcriptional activation by binding to the E-box motif 5'-CANNTG-3'. Required for the correct morphology, terminal identity and function of the ADL sensory neurons by controlling the expression of the ADL-specific gene repertoire, including chemoreceptor encoding genes, ion channel encoding genes, neuropeptides and the neurotransmitter eat-4. Regulates the expression of the srh-234 chemoreceptor encoding gene in the ADL neurons under feeding conditions. Plays a role in the chemorepulsive response toward asca [...]


ensembl_gene_id: T05G5.3.2
symbol: cdk-1
gene_biotype: protein_coding
description:
  Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II (By similarity).


ensembl_gene_id: T05G5.7a.2
symbol: rmd-1
gene_biotype: protein_coding
description:
  Regulator of microtubule dynamics protein 1; Acts in chromosome segregation and organization during mitosis; Belongs to the FAM82/RMD family.


ensembl_gene_id: T05G5.8a.1
symbol: vps-53
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 53 homolog; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex facilitates tethering as well as SNARE complex assembly at the Golgi. Plays a role in the trafficking of cargo to dense-core vesicles, probably through association with the EARP-interacting protein eipr-1. Important for neuronal function.


ensembl_gene_id: T05H10.5b.1
symbol: ufd-2
gene_biotype: protein_coding
description:
  Ubiquitin conjugation factor E4 ufd-2; Acts as an E4 ubiquitin ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. The elongation of preexisting ubiquitin chains preferentially targets ubiquitin 'Lys-29' and 'Lys-48' residues. Also functions as an E3 ligase in conjunction with specific E1 and E2 ligases. Probably by regulating protein ubiquitination at DNA damage repair sites, coordinates DNA double- strand-break repair and apoptosis in the germline. Required for germline apoptosis in response to DNA damage downstream of cep [...]


ensembl_gene_id: T05H10.6b.1
symbol: pdha-1
gene_biotype: protein_coding
description:
  Probable pyruvate dehydrogenase E1 component subunit alpha, mitochondrial; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).


ensembl_gene_id: T05H4.4.1
symbol: T05H4.4
gene_biotype: protein_coding
description:
  NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.


ensembl_gene_id: T05H4.6a.1
symbol: erfa-1
gene_biotype: protein_coding
description:
  Eukaryotic peptide chain release factor subunit 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Belongs to the eukaryotic release factor 1 family.


ensembl_gene_id: T06C12.10.1
symbol: cgt-1
gene_biotype: protein_coding
description:
  Ceramide glucosyltransferase 1; Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide. Belongs to the glycosyltransferase 2 family.


ensembl_gene_id: T06C12.13a.1
symbol: nhr-213
gene_biotype: protein_coding
description:
  Nuclear hormone receptor family member nhr-213; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family.


ensembl_gene_id: T06D8.6.2
symbol: cchl-1
gene_biotype: protein_coding
description:
  Probable cytochrome c-type heme lyase; Links covalently the heme group to the apoprotein of cytochrome c.


ensembl_gene_id: T06D8.7.1
symbol: fndc-1
gene_biotype: protein_coding
description:
  FUN14 domain-containing protein fndc-1; Mitophagy receptor which plays a role in paternal mitochondria degradation in embryos after the two-cell stage.


ensembl_gene_id: T06E4.3a.1
symbol: atl-1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase ATR; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor (By similarity). Recognizes the substrate consensus sequence [ST]-Q (By similarity). Phosphorylates various proteins, which collectively inhibits DNA replication and mitosis and promotes DNA repair and recombination (By similarity). Prevents mitotic catastrophe by functioning in the S-phase checkpoint and cooperating with atm-1 in the c [...]


ensembl_gene_id: T06E6.2a.1
symbol: cyb-3
gene_biotype: protein_coding
description:
  G2/mitotic-specific cyclin-B3; Could be involved at the G2/M (mitosis) transition (Probable). Interacts with the CDK1 and CDK2 protein kinases (Probable). G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis (Probable). Plays a role during oocyte meiosis II.


ensembl_gene_id: T06E8.1a.1
symbol: acl-2
gene_biotype: protein_coding
description:
  Putative 1-acyl-sn-glycerol-3-phosphate acyltransferase acl-2; Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.


ensembl_gene_id: T06G6.9.1
symbol: pfd-3
gene_biotype: protein_coding
description:
  Probable prefoldin subunit 3; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity); Belongs to the prefoldin subunit alpha family.


ensembl_gene_id: T06H11.1a.1
symbol: unc-58
gene_biotype: protein_coding
description:
  Uncoordinated protein 58; Has a role in mobility, possibly in the transport of potassium in muscles; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.


ensembl_gene_id: T07A5.2.1
symbol: unc-50
gene_biotype: protein_coding
description:
  Protein unc-50; Required for cell surface expression of acetylcholine receptors in body-wall muscles.


ensembl_gene_id: T07A9.3.1
symbol: kgb-1
gene_biotype: protein_coding
description:
  GLH-binding kinase 1; Mitogen-activated protein kinase which is an essential component of the JNK pathway composed of mlk-1, mek-1 and kgb-1. Phosphorylates the transcription factor fos-1 which prevents fos-1 dimerization and promoter binding and results in activation of target genes including F53A9.2/kreg-1 and lys-3/kreg-2. Phosphorylates jun-1 and activates the AP-1 transcription factor which is a heterodimer of jun-1 and fos-1. Phosphorylates glh-1 in vitro which may play a role in controlling glh-1 protein levels in the germline by targeting it for degradation by the proteasome. R [...]


ensembl_gene_id: T07A9.5b.1
symbol: eri-1
gene_biotype: protein_coding
description:
  3'-5' exonuclease eri-1; RNA exonuclease that acts as a negative regulator of RNA interference (RNAi). Probably acts by degrading the 3'-overhangs of short interfering RNAs (siRNAs). Its tissue specificity may help explain the inefficiency of neuronal RNAi.


ensembl_gene_id: T07A9.6.1
symbol: daf-18
gene_biotype: protein_coding
description:
  Abnormal dauer formation protein 18; Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins (By similarity). Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate. By dephosphorylating PtdIns(3,4,5)P3 antagonizes PtdIns(3,4,5)P3 production by age-1/PI3K and thus, negatively regulates daf-2-mediated processes including dauer formation, longevity, fat metabolism, chemotaxis towards salt, thermotolerance and axon guidance. Similarly,  [...]


ensembl_gene_id: T07A9.7.1
symbol: gpa-4
gene_biotype: protein_coding
description:
  Guanine nucleotide-binding protein alpha-4 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems; Belongs to the G-alpha family. G(i/o/t/z) subfamily.


ensembl_gene_id: T07A9.8.1
symbol: rrp-8
gene_biotype: protein_coding
description:
  Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family.


ensembl_gene_id: T07A9.9.2
symbol: nog-1
gene_biotype: protein_coding
description:
  Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit (By similarity). Has a role in regulating longevity, growth and brood size. May regulate fat storage via the insulin/IGF pathway.


ensembl_gene_id: T07C4.1.2
symbol: umps-1
gene_biotype: protein_coding
description:
  Orotidine 5'-phosphate decarboxylase; Bifunctional enzyme which catalyzes the formation of UMP from orotate in the de novo pathway of pyrimidine biosynthesis. May also form UMP from uracil. Regulates the size of gut granules during embryonic development. Involved in resistance to DNA damaging agents including UV-C and X-ray radiation. In the C-terminal section; belongs to the OMP decarboxylase family.


ensembl_gene_id: T07C4.2.1
symbol: tbx-8
gene_biotype: protein_coding
description:
  T-box transcription factor tbx-8; Involved in the control of early morphogenesis of the intestine, hypodermis and body-wall muscle. Appears to have partially redundant function to tbx-9.


ensembl_gene_id: T07C4.6.1
symbol: tbx-9
gene_biotype: protein_coding
description:
  T-box transcription factor tbx-9; Involved in the control of early morphogenesis of the intestine, hypodermis and body-wall muscle. Appears to have partially redundant function to tbx-8.


ensembl_gene_id: T07C4.7a.2
symbol: mev-1
gene_biotype: protein_coding
description:
  Succinate dehydrogenase cytochrome b560 subunit, mitochondrial; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (By similarity). Mediates resistance to enteropathogenic E.coli infection. Belongs to the cytochrome b560 family.


ensembl_gene_id: T07C4.8.1
symbol: ced-9
gene_biotype: protein_coding
description:
  Apoptosis regulator ced-9; Plays a major role in programmed cell death (PCD, apoptosis). egl-1 binds to and directly inhibits the activity of ced-9, releasing the cell death activator ced-4 from a ced-9/ced-4 containing protein complex and allowing ced-4 to activate the cell-killing caspase ced-3. During larval development, required for the elimination of transient presynaptic components downstream of egl-1 and upstream of ced-4 and ced-3 apoptotic pathway.


ensembl_gene_id: T07D1.1b.1
symbol: gcy-31
gene_biotype: protein_coding
description:
  Soluble guanylate cyclase gcy-31; Synthesizes cyclic GMP (cGMP) from GTP. May play a role in embryogenesis.


ensembl_gene_id: T07D1.4d.1
symbol: fox-1
gene_biotype: protein_coding
description:
  Sex determination protein fox-1; A member of the sex determination pathway involved in making the distinction between one and two X-chromosomes. RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUG-3' elements. Regulates alternative splicing of tissue-specific exons. Promotes binding of sup-12 to target RNA.


ensembl_gene_id: T07D10.2.1
symbol: ntr-1
gene_biotype: protein_coding
description:
  Nematocin receptor 1; Receptor for nematocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. The activity of this receptor may be modulated by ntr-2, leading to reduced intracellular cAMP production. Plays a role in gustatory associative learning. Also plays a role in male mating behavior ; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.


ensembl_gene_id: T07D4.3.1
symbol: rha-1
gene_biotype: protein_coding
description:
  ATP-dependent RNA helicase A; Multifunctional ATP-dependent nucleic acid helicase that unwinds DNA and RNA in a 3' to 5' direction and that plays important roles in many processes, such as DNA replication, transcriptional activation, post-transcriptional RNA regulation, mRNA translation and RNA-mediated gene silencing. Requires a 3'-single-stranded tail as entry site for acid nuclei unwinding activities as well as the binding and hydrolyzing of any of the four ribo- or deoxyribo-nucleotide triphosphates (NTPs). Binds to DNA, RNA and small interfering siRNA. Plays a role in DNA replicat [...]


ensembl_gene_id: T07E3.5.1
symbol: brc-2
gene_biotype: protein_coding
description:
  DNA repair protein brc-2; Required for the homologous recombination repair of DNA double strand breaks, thereby playing a role in chromosome integrity. Acts by targeting rad-51 to sites of DNA damage and stabilizing rad-51-DNA filaments by blocking ATP hydrolysis catalyzed by rad-51. Promotes rad-51 mediated displacement-loop (D-loop) formation during strand invasion between the invading single-stranded DNA (ssDNA) and the homologous duplex DNA. Also functions independently of rad-51 in DNA double-strand break (DSB) repair by promoting DNA single-strand annealing (SSA) when the homolog [...]


ensembl_gene_id: T07F8.3a.1
symbol: gld-3
gene_biotype: protein_coding
description:
  Defective in germ line development protein 3; Required maternally for germline survival and embryogenesis. Forms a complex with gls-1 which promotes the oogenic cell fate by freeing the translational repressor fbf to repress sperm promoting factors. Promotes maturation of primary spermatocytes to mature sperm. Required during hermaphrodite development to promote sperm fate, which is critical for determining the normal number of sperm. Promotion of sperm fate is at the expense of oogenesis, possibly through the negative regulation of fbf. Required during male development for the continu [...]


ensembl_gene_id: T07H6.2.1
symbol: mom-1
gene_biotype: protein_coding
description:
  Protein-serine O-palmitoleoyltransferase porcupine; Key regulator of the Wnt signaling pathway that mediates lipid modification of Wnt proteins. Acts as a protein-serine O-palmitoleoyltransferase that catalyzes the attachment of palmitoleate, a 16-carbon monounsaturated fatty acid (C16:1), to Wnt proteins (By similarity). Serine palmitoleylation of WNT proteins is required for efficient binding to frizzled receptors (By similarity). Has a role in cell specification, specifically in blastomere signaling. Involved in cytosketetal polarity. Required for the orientation of mitotic spindle  [...]


ensembl_gene_id: T07H6.5b.1
symbol: lev-9
gene_biotype: protein_coding
description:
  Protein lev-9; Scaffolding protein that is necessary to cluster acetylcholine receptors at neuromuscular junctions.


ensembl_gene_id: T08B2.8.1
symbol: mrpl-23
gene_biotype: protein_coding
description:
  Probable 39S ribosomal protein L23, mitochondrial; Belongs to the universal ribosomal protein uL23 family.


ensembl_gene_id: T08D10.2.1
symbol: lsd-1
gene_biotype: protein_coding
description:
  Probable lysine-specific histone demethylase 1; Probable histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3.


ensembl_gene_id: T08G11.5.2
symbol: unc-29
gene_biotype: protein_coding
description:
  Acetylcholine receptor subunit beta-type unc-29; Non-alpha subunit of nicotinic acetylcholine receptor (nAChR). Involved in nAChR sensitivity to nicotine and levasimole. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.


ensembl_gene_id: T08G2.3.2
symbol: acdh-10
gene_biotype: protein_coding
description:
  Probable medium-chain specific acyl-CoA dehydrogenase 10, mitochondrial; This enzyme is specific for acyl chain lengths of 4 to 16. Belongs to the acyl-CoA dehydrogenase family.


ensembl_gene_id: T08G5.5b.1
symbol: vps-39
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 39 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways (By similarity). Believed to act in part as a component of the putative HOPS endosomal tethering complex which is proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to rab-7 on th [...]


ensembl_gene_id: T09A5.10.2
symbol: lin-5
gene_biotype: protein_coding
description:
  Spindle apparatus protein lin-5; Essential component of the spindle apparatus required for spindle positioning and chromosome movement. Acts to recruit or anchor gpr-1/gpr-2 complex to the spindle and cortex. Also involved, directly or indirectly, in cytokinesis and in the coupling of DNA replication, centrosome duplication and mitotic division.


ensembl_gene_id: T09A5.11.2
symbol: ostb-1
gene_biotype: protein_coding
description:
  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across t [...]


ensembl_gene_id: T09A5.3.1
symbol: acr-7
gene_biotype: protein_coding
description:
  Acetylcholine receptor subunit alpha-type acr-7; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.


ensembl_gene_id: T09A5.6.1
symbol: mdt-10
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 10; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required [...]


ensembl_gene_id: T09A5.8.1
symbol: cec-3
gene_biotype: protein_coding
description:
  Chromo domain-containing protein cec-3; Specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me), with highest preference for trimethylated 'Lys-9' (H3K9me3) followed by dimethylated 'Lys-9' (H3K9me2) followed by monomethylated 'Lys-9' (H3K9me1). Plays a role in maintaining correct unc-4 expression in the VC motor neurons where unc- 4 is expressed in the vulval but not in the non-vulval VC neurons.


ensembl_gene_id: T09A5.9.1
symbol: sds-22
gene_biotype: protein_coding
description:
  Protein phosphatase 1 regulatory subunit SDS22 homolog; Regulatory subunit of protein phosphatase 1; Belongs to the SDS22 family.


ensembl_gene_id: T09B4.1.2
symbol: pigv-1
gene_biotype: protein_coding
description:
  GPI mannosyltransferase pigv-1; Alpha-1,6-mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis (By similarity). Transfers the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly (By similarity). Required for maintenance of epithelial integrity during embryogenesis. Belongs to the PIGV family.


ensembl_gene_id: T09B4.8.1
symbol: T09B4.8
gene_biotype: protein_coding
description:
  Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.


ensembl_gene_id: T09B4.9.1
symbol: tin-44
gene_biotype: protein_coding
description:
  Probable mitochondrial import inner membrane translocase subunit tin-44; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Recruits mitochondrial HSP70 to drive protein translocation into the matrix using ATP as an energy source.


ensembl_gene_id: T09E11.2.1
symbol: nhr-217
gene_biotype: protein_coding
description:
  Nuclear hormone receptor family member nhr-217; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family.


ensembl_gene_id: T09E8.1h.1
symbol: noca-1
gene_biotype: protein_coding
description:
  Non-centrosomal microtubule array protein 1; Plays a role in the assembly of microtubule arrays in the germline acting redundantly with ptrn-1 to control circumferential microtubule assembly along the body which is necessary for larval development, viability, and morphology and integrity of the epidermis. Required for microtubule stability and anchorage by binding to microtubule minus ends. Recruited to hemidesomosomes in early embryonic elongation to direct the nucleation and growth of non-centrosomal microtubules. [Isoform h]: Directs the assembly of non-centrosomal microtubule array [...]


ensembl_gene_id: T09E8.3.1
symbol: cni-1
gene_biotype: protein_coding
description:
  Protein cornichon homolog 1; Negatively regulates export of glr-1 from the endoplasmic reticulum to synapses.


ensembl_gene_id: T10A3.1a.1
symbol: unc-10
gene_biotype: protein_coding
description:
  Rab-3-interacting molecule unc-10; Regulates the efficiency of a post-docking step of the release pathway. Acts after vesicle docking likely via regulating priming. May regulate the conformational changes in syntaxin. Binding of vesicles via rab-3[GTP] to Rim may signal the presence of a docked synaptic vesicle. Rim may then signal to unc-13 to change the conformation of syntaxin from the closed to the open state. Syntaxin could then engage synaptobrevin on the docked vesicle to form SNARE complexes and to prime the vesicle for release. Not required for the development or the structura [...]


ensembl_gene_id: T10B5.5a.2
symbol: cct-7
gene_biotype: protein_coding
description:
  T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.


ensembl_gene_id: T10B9.1.1
symbol: cyp-13A4
gene_biotype: protein_coding
description:
  Putative cytochrome P450 CYP13A4; Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.


ensembl_gene_id: T10B9.10.1
symbol: cyp-13A7
gene_biotype: protein_coding
description:
  Putative cytochrome P450 CYP13A7; Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.


ensembl_gene_id: T10B9.2.1
symbol: cyp-13A5
gene_biotype: protein_coding
description:
  Putative cytochrome P450 CYP13A5; Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.


ensembl_gene_id: T10B9.3.1
symbol: cyp-13A6
gene_biotype: protein_coding
description:
  Putative cytochrome P450 CYP13A6; Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.


ensembl_gene_id: T10B9.4.1
symbol: cyp-13A8
gene_biotype: protein_coding
description:
  Putative cytochrome P450 CYP13A8; Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.


ensembl_gene_id: T10B9.5.1
symbol: cyp-13A3
gene_biotype: protein_coding
description:
  Putative cytochrome P450 CYP13A3; Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.


ensembl_gene_id: T10B9.7.1
symbol: cyp-13A2
gene_biotype: protein_coding
description:
  Putative cytochrome P450 CYP13A2; Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.


ensembl_gene_id: T10B9.8.1
symbol: cyp-13A1
gene_biotype: protein_coding
description:
  Putative cytochrome P450 CYP13A1; Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.


ensembl_gene_id: T10C6.3.1
symbol: srx-43
gene_biotype: protein_coding
description:
  Serpentine receptor class X-43; Receptor for the ascaroside pheromone icas#9 which suppresses exploratory forgaging behavior. In response to ascaroside icas#9, may furthermore play a role in the expression of genes in the TGF-beta signaling pathway, such as daf-7, and in insulin signaling pathway, such as daf-28, which may in turn contribute to exploratory behavior. Belongs to the G-protein coupled receptor 1 family.


ensembl_gene_id: T10C6.5.1
symbol: cwc-15
gene_biotype: protein_coding
description:
  Spliceosome-associated protein CWC15 homolog; Component of a spliceosomal complex that is required for activating pre-mRNA splicing.


ensembl_gene_id: T10F2.1a.1
symbol: gars-1
gene_biotype: protein_coding
description:
  Glycine--tRNA ligase; Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis. Belongs to the class-II aminoacyl-tRNA synthetase family.


ensembl_gene_id: T10F2.3.1
symbol: ulp-1
gene_biotype: protein_coding
description:
  Sentrin-specific protease; Protease that deconjugates smo-1 from targeted proteins and may catalyze the processing of smo-1 to its mature form.


ensembl_gene_id: T10F2.4.1
symbol: prp-19
gene_biotype: protein_coding
description:
  Pre-mRNA-processing factor 19; Probable ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Core component of the NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity (By similarity). Together with emb-4, necessary for interaction of rnp-4, a probable exon junction complex component, with mRNAs and spliceosomal snRNAs. Plays a role in nuclear retention of unspliced mRNAs. Belongs to the WD repeat PRP19 family.


ensembl_gene_id: T10G3.6a.1
symbol: gut-2
gene_biotype: protein_coding
description:
  U6 snRNA-associated Sm-like protein LSm2; Binds specifically to the 3'-terminal U-tract of U6 snRNA.


ensembl_gene_id: T10H10.1.1
symbol: hum-6
gene_biotype: protein_coding
description:
  Unconventional myosin heavy chain 6; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity).


ensembl_gene_id: T10H9.2.1
symbol: scd-2
gene_biotype: protein_coding
description:
  ALK tyrosine kinase receptor homolog scd-2; Probable tyrosine-protein kinase receptor which regulates the dauer/non-dauer developmental decision probably by controlling daf-3 transcriptional activity in parallel or together with the TGF-beta pathway. Regulates integration of conflicting sensory cues in AIA interneurons. May act as a receptor for hen-1.


ensembl_gene_id: T10H9.4.1
symbol: snb-1
gene_biotype: protein_coding
description:
  Synaptobrevin-1; Involved in the targeting and/or fusion of transport vesicles to their target membrane. Acts in neuronal exocytosis of synaptic transmission. Likely to have a role in cholinergic transmisson. Required for viability, coordinated movement and M3 pharynx motor neuron function.


ensembl_gene_id: T11F9.4a.1
symbol: aat-6
gene_biotype: protein_coding
description:
  Amino acid transporter protein 6; Amino acid transporter that mediates the uptake of the L- enantiomers of various amino acids, including L-glutamate (Probable). May play a role in promoting fertility.


ensembl_gene_id: T11G6.1a.1
symbol: hars-1
gene_biotype: protein_coding
description:
  Histidine--tRNA ligase; Involved in protein synthesis. Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA (Probable). Required for germ cell development. Belongs to the class-II aminoacyl-tRNA synthetase family.


ensembl_gene_id: T12A2.2.1
symbol: stt-3
gene_biotype: protein_coding
description:
  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit stt-3; Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation [...]


ensembl_gene_id: T12C9.6.1
symbol: nhr-16
gene_biotype: protein_coding
description:
  Nuclear hormone receptor family member nhr-16; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family.


ensembl_gene_id: T12D8.4.1
symbol: arrd-17
gene_biotype: protein_coding
description:
  Arrestin domain-containing protein 17; Involved in several behavioral responses including chemotaxis towards lysine and adaptation to repeated osmotic stress. In addition, plays a role in resuming egg-laying and locomotion after starvation.


ensembl_gene_id: T12D8.6.1
symbol: mlc-5
gene_biotype: protein_coding
description:
  Myosin-2 essential light chain; Required for cytokinesis and embryo elongation. May regulate myosin II complex formation and/or the association of myosin with actin. May be involved in the organization of mlc-4 and nmy-2 into bundles.


ensembl_gene_id: T12E12.1.1
symbol: ari-2
gene_biotype: protein_coding
description:
  Potential E3 ubiquitin-protein ligase ariadne-2; Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBC-2/UBE2L3, and then transfers it to substrates. Belongs to the RBR family. Ariadne subfamily.


ensembl_gene_id: T12E12.4b.3
symbol: drp-1
gene_biotype: protein_coding
description:
  Dynamin-Related Protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.


ensembl_gene_id: T12F5.3.1
symbol: glh-4
gene_biotype: protein_coding
description:
  ATP-dependent RNA helicase glh-4; Probable ATP-binding RNA helicase. May act redundantly with the P-granule component glh-1 to regulate the formation of the granular structure of P-granules in embryos. May protect somatic cells from excessive apoptosis during normal development.


ensembl_gene_id: T12F5.4.1
symbol: lin-59
gene_biotype: protein_coding
description:
  Probable histone-lysine N-methyltransferase lin-59; Probable histone methyltransferase (By similarity). Essential protein required to maintain expression of homeotic genes egl-5 and mab-5. May play an analogous role to the trithorax Group (trxG) proteins. TrxG proteins form multiprotein complexes that are required to maintain the transcriptionally active state of homeotic genes throughout development. May act via a modification of chromatin.


ensembl_gene_id: T12G3.5.2
symbol: mrpl-51
gene_biotype: protein_coding
description:
  39S ribosomal protein L51, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mL51 family.


ensembl_gene_id: T12G3.8a.1
symbol: bre-5
gene_biotype: protein_coding
description:
  Beta-1,3-galactosyltransferase bre-5; Transfers N-acetylgalactosamine onto mannose groups of carbohydrate substrates. Required for susceptibility to pore-forming crystal toxins in conjunction with bre-1, bre-2, bre-3, and bre-4. Involved in resistance to the nematotoxic C.cinerea galectin Cgl2.


ensembl_gene_id: T13A10.11a.1
symbol: sams-5
gene_biotype: protein_coding
description:
  Probable S-adenosylmethionine synthase 5; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.


ensembl_gene_id: T13B5.1.1
symbol: snf-3
gene_biotype: protein_coding
description:
  Sodium- and chloride-dependent betaine transporter; Betaine transporter dependent on Na(+) and Cl(-) ions that functions primarily in the epidermis to clear betaine from the extracellular space. Elicits current in response to betaine but not in response to GABA, L-carnitine, sarcosine, glycine or dimethylglycine. Belongs to the sodium:neurotransmitter symporter (SNF) family.


ensembl_gene_id: T13B5.4.1
symbol: col-40
gene_biotype: protein_coding
description:
  Cuticle collagen 40; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.


ensembl_gene_id: T13C2.4.1
symbol: ssup-72
gene_biotype: protein_coding
description:
  RNA polymerase II subunit A C-terminal domain phosphatase ssup-72; Protein phosphatase that dephosphorylates 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the large RNA polymerase II subunit ama-1. By regulating the phosphorylation status of ama-1 and thus ama-1 binding to specific polyadenylation sites, regulates alternative polyadenylation of pre- mRNAs, including unc-44 and dlk-1 mRNAs. This results in the tissue-specific expression of unc-44 isoforms.


ensembl_gene_id: T13C5.1a.1
symbol: daf-9
gene_biotype: protein_coding
description:
  Cytochrome P450 daf-9; Sterol hydroxylase that catalyzes the successive oxidization of the side chains of the 3-keto steroids 4-cholesten-3-one and lathosterone to form their carboxylic acid derivatives Delta(4)- dafachronic acid and Delta(7)-dafachronic acid respectively. Dafachronic acids bind directly to the nuclear hormone receptor (NHR) daf-12, suppressing dauer formation and inducing reproductive growth. In a non-cell autonomous manner, negatively regulates body wall muscle arm extensions to motor neurons probably by preventing daf-12 isoform b activation. May be involved in ther [...]


ensembl_gene_id: T13C5.5.1
symbol: bca-1
gene_biotype: protein_coding
description:
  Beta carbonic anhydrase 1; Reversible hydration of carbon dioxide; Belongs to the beta-class carbonic anhydrase family.


ensembl_gene_id: T13C5.8.2
symbol: mtp-18
gene_biotype: protein_coding
description:
  Mitochondrial fission process protein 1; Involved in the mitochondrial division probably by regulating membrane fission. Loss-of-function leads to apoptosis (By similarity). Belongs to the MTFP1 family.


ensembl_gene_id: T13F2.11.1
symbol: msp-78
gene_biotype: protein_coding
description:
  Major sperm protein 78; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.


ensembl_gene_id: T13F2.1a.1
symbol: fat-4
gene_biotype: protein_coding
description:
  Delta(5) fatty acid desaturase fat-4; Catalyzes the desaturation of dihomo-gamma-linoleic acid (DHGLA) (20:3n-6) to generate arachidonic acid (20:4n-6). Also acts on a number of other substrates, including fatty acids that do not contain a double bond at the 8 position; Belongs to the fatty acid desaturase type 1 family.


ensembl_gene_id: T13F2.2.1
symbol: T13F2.2
gene_biotype: protein_coding
description:
  Putative RNA polymerase II transcriptional coactivator; General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. Binds single-stranded DNA (By similarity).


ensembl_gene_id: T13F2.8a.1
symbol: cav-1
gene_biotype: protein_coding
description:
  Caveolin-1; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.


ensembl_gene_id: T13F3.2a.1
symbol: nhr-218
gene_biotype: protein_coding
description:
  Nuclear hormone receptor family member nhr-218; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family.


ensembl_gene_id: T13F3.3.1
symbol: nhr-127
gene_biotype: protein_coding
description:
  Nuclear hormone receptor family member nhr-127; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family.


ensembl_gene_id: T13G4.3.1
symbol: tmc-1
gene_biotype: protein_coding
description:
  Transmembrane channel-like protein 1; Sodium-sensor ion channel that acts specifically in salt taste chemosensation. Required for salt-evoked neuronal activity and behavioral avoidance of high concentrations of NaCl. Belongs to the TMC family.


ensembl_gene_id: T13H5.7.1
symbol: rnh-2
gene_biotype: protein_coding
description:
  Ribonuclease H2 subunit A; Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes (By similarity).


ensembl_gene_id: T14A8.1.1
symbol: ric-3
gene_biotype: protein_coding
description:
  Resistance to inhibitors of cholinesterase protein 3; Required for maturation and cell surface expression of acetylcholine receptors; Belongs to the ric-3 family.


ensembl_gene_id: T14B1.2.1
symbol: aex-2
gene_biotype: protein_coding
description:
  G-protein coupled receptor aex-2; G-protein coupled receptor for the nlp-40 neuropeptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Plays a role in the defecation motor program, which is a coordinated series of three muscle contractions that occurs every 45 seconds. Specifically, acts in GABAergic neurons, such as AVL and DVB, to control the expulsion step of defecation. Required for fatty acid uptake and metabolism by intestinal cells and therefore regulates the levels of triglycerides in the intestine.


ensembl_gene_id: T14B4.6.1
symbol: dpy-2
gene_biotype: protein_coding
description:
  Cuticle collagen dpy-2; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment. Mutations in dpy-2 affects the body shape.


ensembl_gene_id: T14B4.7.1
symbol: dpy-10
gene_biotype: protein_coding
description:
  Cuticle collagen dpy-10; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.


ensembl_gene_id: T14E8.1a.1
symbol: svh-2
gene_biotype: protein_coding
description:
  Tyrosine-protein kinase receptor svh-2; Receptor tyrosine kinase which may phosphorylate mlk-1, a component of the mlk-1, mek-1 and kgb-1 pathway. Involved in axon regeneration after injury by promoting the generation of productive and stable growth cones.


ensembl_gene_id: T14E8.3b.1
symbol: dop-3
gene_biotype: protein_coding
description:
  Dopamine receptor 3; Receptor for dopamine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. In terms of antagonist responses, would be classed with the D2-like dopamine receptor group. Mediates the effect of dopamine on the inhibition of locomotion. Acts as an antagonist of dop-1.


ensembl_gene_id: T14F9.1.1
symbol: vha-15
gene_biotype: protein_coding
description:
  Probable V-type proton ATPase subunit H 2; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates the ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (By similarity).


ensembl_gene_id: T14F9.3.1
symbol: hex-1
gene_biotype: protein_coding
description:
  Beta-hexosaminidase A; Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines. Degrades chitotriose.


ensembl_gene_id: T14F9.5.1
symbol: lin-32
gene_biotype: protein_coding
description:
  Protein lin-32; Essential for the specification of the neuroblast cell fate in the development of peripheral sense organs. Its role in the generation of sensory neurons may be through positively regulating the expression of the zinc finger protein ztf-11 during postdeirid neurogenesis.


ensembl_gene_id: T14G10.2a.1
symbol: pxf-1
gene_biotype: protein_coding
description:
  Rap guanine nucleotide exchange factor; Acts as a guanine nucleotide exchange factor for small G protein GTPases like rap-1 and rap-2. Required in the hypodermis, especially in the seam cells, for proper formation of the cuticle. Belongs to the RAPGEF2 family.


ensembl_gene_id: T14G10.5c.1
symbol: T14G10.5
gene_biotype: protein_coding
description:
  Probable coatomer subunit gamma; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity).


ensembl_gene_id: T14G10.6.1
symbol: tsp-12
gene_biotype: protein_coding
description:
  Tetraspanin-12; Together with tsp-14, regulates cell fate specification in the postembryonic mesodermal M lineage, body size and male development, probably by positively modulating BMP-like Sma/Mab signaling. May regulate BMP-like Sma/Mab signaling by mediating protease sup-17 trafficking to the cell surface. Together with tsp-14, probably acts by modulating the activation of glp-1, a Notch-like receptor, to regulate germline maturation. Probably acts by modulating the activation of lin-12, a Notch-like receptor, to regulate cell fate specification such as the anchor cell/ventral uteri [...]


ensembl_gene_id: T14G11.3.1
symbol: immt-1
gene_biotype: protein_coding
description:
  MICOS complex subunit MIC60-1; Sustains mitochondrial morphology probably through maintaining cristae morphology. May act as a component of the MICOS complex, a large protein complex of the mitochondria (By similarity).


ensembl_gene_id: T14G12.2.1
symbol: aex-4
gene_biotype: protein_coding
description:
  t-SNARE protein aex-4; t-SNARE protein which regulates the secretion of aex-5 from intestinal cells. Involved in the defecation motor program, which is a coordinated series of three muscle contractions that occurs every 45 seconds; Belongs to the SNAP-25 family.


ensembl_gene_id: T14G8.1.1
symbol: chd-3
gene_biotype: protein_coding
description:
  Chromodomain-helicase-DNA-binding protein 3 homolog; Chromatin-remodeling protein that has a role in notch signaling-dependent vulval cell fate determination. May also have a role in pharyngeal precursor cell specification.


ensembl_gene_id: T15B7.2.2
symbol: hpo-8
gene_biotype: protein_coding
description:
  Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase hpo-8; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precu [...]


ensembl_gene_id: T15D6.6.1
symbol: nhr-77
gene_biotype: protein_coding
description:
  Nuclear hormone receptor family member nhr-77; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family.


ensembl_gene_id: T15H9.3.1
symbol: hlh-6
gene_biotype: protein_coding
description:
  Helix-loop-helix protein 6; Transcription factor that regulates the development of the g2 pharyngeal gland cells and pharyngeal gland function and thereby is required for feeding. Required for the expression of a number of genes in the pharyngeal gland, possibly by binding to the E box motif (5'-CANNTG-3') in the promoter region of these genes. Positively regulates the expression of genes encoding mucin-like proteins, which lubricate the pharyngeal tract to ensure efficient passage of the bacterial food source. Exhibits pharyngeal gland-specific positive autoregulation activity.


ensembl_gene_id: T16G1.11.1
symbol: eif-3.K
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 3 subunit K; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.


ensembl_gene_id: T16H12.4.2
symbol: gtf-2H2C
gene_biotype: protein_coding
description:
  General transcription factor IIH subunit 2; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFII [...]


ensembl_gene_id: T16H12.5a.1
symbol: bath-43
gene_biotype: protein_coding
description:
  BTB and MATH domain-containing protein 43; In complex with a cullin, may act in ubiquitination and proteasomal degradation processes.


ensembl_gene_id: T16H5.1a.1
symbol: inx-19
gene_biotype: protein_coding
description:
  Innexin-19; Structural component of the gap junctions that specifically coordinates left-right asymmetry in the developing nervous system. Acts by forming gap junction network linking embryonic neurons and providing electrical coupling between cells, leading to promote or inhibit AWC signaling. Required for the left and right AWC olfactory neurons to establish asymmetric patterns of gene expression during embryogenesis. Acts autonomously.


ensembl_gene_id: T17A3.1.1
symbol: ver-1
gene_biotype: protein_coding
description:
  Protein ver-1; Involved in amphid glia remodeling during entry into dauer stage by promoting the fusion of sheath amphid cells which encloses AWC neuron sensory endings. May be involved, downstream of pvf-1, in the positioning of ray 1, the most anterior ray sensillum in the male tail.


ensembl_gene_id: T17A3.13.1
symbol: sqst-5
gene_biotype: protein_coding
description:
  Protein ver-2; May be involved, downstream of pvf-1, in the positioning of ray 1, the most anterior ray sensillum in the male tail.


ensembl_gene_id: T17E9.1a.1
symbol: kin-18
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase SULU; Acts as a negative regulator of cortical contractions during early embryonic cell division, possibly by regulating rho-1-dependent actomyosin contractility. Plays a role in polarity establishment in early embryos by regulating the size of the anterior and posterior cortex in the first asymmetric cell division. Might play a role in cell cycle progression. In the germline, involved in the regulation of meiotic progression during oogenesis, possibly by modulating the timing of mpk-1 activation. Plays a role in meiotic recombination events. Involved in [...]


ensembl_gene_id: T17E9.2b.1
symbol: nmt-1
gene_biotype: protein_coding
description:
  Probable glycylpeptide N-tetradecanoyltransferase; Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.


ensembl_gene_id: T18D3.2.1
symbol: odr-7
gene_biotype: protein_coding
description:
  Nuclear hormone receptor family member odr-7; Required for the function of one pair of chemosensory neurons called AWA neurons that are involved in chemotaxis to volatile odorants. Acts in a pathway that specifies olfactory neuronal fate. Regulates the transcription of olfactory signaling molecules such as odr-10 that specify AWA neuron identity and function. Represses the expression in AWA neurons of factors such as str-2 which specify AWC neuron identity.


ensembl_gene_id: T18D3.9.1
symbol: T18D3.9
gene_biotype: protein_coding
description:
  Mpv17-like protein; Involved in mitochondria homeostasis; Belongs to the peroxisomal membrane protein PXMP2/4 family.


ensembl_gene_id: T19A5.2b.1
symbol: gck-1
gene_biotype: protein_coding
description:
  Germinal center kinase 1; Serine/threonine-protein kinase which is required for normal oogenesis and suppression of germline cell apoptosis. Inhibits phosphorylation and thus probably activation of mpk-1 during pachytene stage. Involved in excretory canal elongation during postembryonic development, probably acting downstream of ccm-3 ; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.


ensembl_gene_id: T19A5.4.1
symbol: nhr-44
gene_biotype: protein_coding
description:
  Nuclear hormone receptor family member nhr-44; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family.


ensembl_gene_id: T19A6.2a.1
symbol: ngp-1
gene_biotype: protein_coding
description:
  Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.


ensembl_gene_id: T19A6.3b.1
symbol: nepr-1
gene_biotype: protein_coding
description:
  Nuclear envelope phosphatase-regulatory subunit 1 homolog; May form with the serine/threonine protein phosphatase scpl-2 an active complex dephosphorylating and activating lipin-like phosphatases. Lipins are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels. May play a role in nuclear membrane dynamics being crucial for early development of the embryo.


ensembl_gene_id: T19B10.6.2
symbol: dvc-1
gene_biotype: protein_coding
description:
  SprT-like domain-containing protein Spartan; Regulator of UV-induced DNA damage response: required to protect genome stability during DNA replication, possibly via recruitment of vcp/p97 (cdc-48.1 or cdc-48.2) recruitment. Belongs to the Spartan family.


ensembl_gene_id: T19B10.7.2
symbol: ima-1
gene_biotype: protein_coding
description:
  Importin subunit alpha-1; Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Promotes docking of import substrates to the nuclear envelope. Seems to act as a cytosolic receptor for both simple and bipartite NLS motifs (By similarity). Belongs to the importin alpha family.


ensembl_gene_id: T19B10.8.1
symbol: T19B10.8
gene_biotype: protein_coding
description:
  GPI inositol-deacylase; Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.


ensembl_gene_id: T19B4.1.1
symbol: pamn-1
gene_biotype: protein_coding
description:
  Probable peptidyl-glycine alpha-amidating monooxygenase pamn-1; Probable bifunctional enzyme that catalyzes 2 sequential steps in C-terminal alpha-amidation of peptides. The monooxygenase part produces an unstable peptidyl(2-hydroxyglycine) intermediate that is dismutated to glyoxylate and the corresponding desglycine peptide amide by the lyase part. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity; In the N-terminal section; belongs to the copper type II ascorbate-dependent monooxygenase family.


ensembl_gene_id: T19B4.3.1
symbol: T19B4.3
gene_biotype: protein_coding
description:
  Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family.


ensembl_gene_id: T19B4.4.1
symbol: dnj-21
gene_biotype: protein_coding
description:
  Mitochondrial import inner membrane translocase subunit TIM14; Probable component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity (By similarity).


ensembl_gene_id: T19C3.8.2
symbol: fem-2
gene_biotype: protein_coding
description:
  Protein phosphatase fem-2; Dephosphorylates auto-phosphorylated Ca(2+)/calmodulin- dependent protein kinase unc-43/CAMKII in vitro. Involved in the regulation of sex determination. Together with fem-3, required for male sexual development by promoting the proteasomal-mediated degradation of tra-1, a transcription repressor of male-specific genes. Promotes apoptosis. Belongs to the PP2C family.


ensembl_gene_id: T19C4.6a.1
symbol: gpa-1
gene_biotype: protein_coding
description:
  Guanine nucleotide-binding protein alpha-1 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems; Belongs to the G-alpha family.


ensembl_gene_id: T19C4.7.1
symbol: nlp-33
gene_biotype: protein_coding
description:
  Neuropeptide-like protein 33; May have antifungic activity against D.coniospora; Belongs to the YARP (YGGW-amide related peptide) family.


ensembl_gene_id: T19E7.2a.1
symbol: skn-1
gene_biotype: protein_coding
description:
  Protein skinhead-1; Transcription factor required to specify the fate of ventral blastomeres in the early embryo, and postembryonically for the development of the intestine. Directly regulates expression of zygotically expressed med-1 and med-2 to direct mesendoderm development. Required for stl-1 mRNA up- regulation in response to oxidative stress and anoxia. Required for the up-regulation of gcs-1 and several glutathione-S-transferase mRNAs in response to oxidative stress generated during pathogenic bacterial infection. In neurons, involved in mitochondrial fusion and behavioral reco [...]


ensembl_gene_id: T19E7.3a.1
symbol: bec-1
gene_biotype: protein_coding
description:
  Beclin homolog; Regulates autophagy. Together with phosphatidyl-3-phosphate kinase vps-34, acts as a core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3- phosphate (PtdIns3P), thereby regulating membrane trafficking. In association with sorf-1 and sorf-2, negatively regulates phosphatidylinositol 3- phosphate in early endosomes to allow for the conversion to late endosomes. Involved in the clearance of engulfed apoptotic cell corpses. Together with ced-9, negatively regulates somatic and germline apoptosis. Plays a role in endosome-to-Golgi retrograde tra [...]


ensembl_gene_id: T20B12.1.1
symbol: trd-1
gene_biotype: protein_coding
description:
  Tetratricopeptide repeat-containing protein trd-1; Developmental protein required for cell fate determination in both the germline and seam cells of the developing epidermis. Specifically, involved in sex determination and may function in parallel or downstream of other sex determination factors, including tra-2 and fem-3, to promote oogenesis in its role in the regulation of the switch from spermatogenesis to oogenesis in the gonads. Also implicated in the mitosis to meiosis switch in distal tip cells.


ensembl_gene_id: T20B12.2.1
symbol: tbp-1
gene_biotype: protein_coding
description:
  TATA-box-binding protein; General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II.


ensembl_gene_id: T20B12.6a.1
symbol: mml-1
gene_biotype: protein_coding
description:
  Protein WBSCR14 homolog; Transcriptional repressor. Binds to the canonical and non- canonical E box sequences 5'-CACGTG-3' (By similarity).


ensembl_gene_id: T20B12.7.1
symbol: T20B12.7
gene_biotype: protein_coding
description:
  Anamorsin homolog; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the cytosolic Fe-S scaffold complex. Electrons are transferred from NADPH via a FAD- and FMN-containing diflavin oxidoreductase. Together with the diflavin oxidoreductase, also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RN [...]


ensembl_gene_id: T20B12.8.1
symbol: hmg-4
gene_biotype: protein_coding
description:
  FACT complex subunit SSRP1-A; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment [...]


ensembl_gene_id: T20B3.2.2
symbol: tni-3
gene_biotype: protein_coding
description:
  Troponin I 3; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to muscle actomyosin ATPase activity.


ensembl_gene_id: T20B5.1.1
symbol: apa-2
gene_biotype: protein_coding
description:
  AP-2 complex subunit alpha; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.


ensembl_gene_id: T20D3.7c.1
symbol: vps-26
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 26; May play a role in vesicular protein sorting, similar to the yeast retromer proteins.


ensembl_gene_id: T20F10.1.1
symbol: wts-1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase WARTS homolog; Phosphorylates yap-1 which may negatively regulate yap-1 nuclear localization. Plays an essential role in larval development. Regulates growth, the formation of gut granules, lifespan and cell and body sizes probably in synergy with the TGF-beta sma/mab pathway. Does not appear to regulate apoptosis and proliferation. In addition, may synergize with the TGF-beta daf-7 dauer pathway to regulate entry into the dauer stage. Maintains the cellular integrity of intestinal cells by regulating the localization of apical actin and junctional proteins.


ensembl_gene_id: T20F5.2.1
symbol: pbs-4
gene_biotype: protein_coding
description:
  Proteasome subunit beta type-2; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity); Belongs to the peptidase T1B family.


ensembl_gene_id: T20F5.3.2
symbol: mrrf-1
gene_biotype: protein_coding
description:
  Ribosome-recycling factor, mitochondrial; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity); Belongs to the RRF family.


ensembl_gene_id: T20G5.1.1
symbol: chc-1
gene_biotype: protein_coding
description:
  Probable clathrin heavy chain 1; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles (By similarity). May play a role in yolk protein clatherin-mediated endocytosis by oocytes during oogenesis ; Belongs to the clathrin heavy chain family.


ensembl_gene_id: T20G5.10.1
symbol: blos-1
gene_biotype: protein_coding
description:
  Biogenesis of lysosome-related organelles complex 1 subunit 1; Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1), a complex involved in gut granule biogenesis. May negatively regulate aerobic respiration through mitochondrial protein lysine-acetylation.


ensembl_gene_id: T20G5.5.1
symbol: epac-1
gene_biotype: protein_coding
description:
  Rap guanine nucleotide exchange factor 1; Guanine nucleotide-releasing protein (By similarity). Together with GTPase drn-1, may regulate acetylcholine release at the neuromuscular junctions probably downstream of G-protein gsa-1 and adenylate cyclase acy-1.


ensembl_gene_id: T20G5.6.2
symbol: unc-47
gene_biotype: protein_coding
description:
  Vesicular GABA transporter; Involved in the uptake of GABA into the synaptic vesicles. Belongs to the amino acid/polyamine transporter 2 family.


ensembl_gene_id: T20H4.4.2
symbol: adr-2
gene_biotype: protein_coding
description:
  Double-stranded RNA-specific adenosine deaminase adr-2; Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. Acts primarily on non-coding regions of protein- coding genes including introns and untranslated regions (UTR). Required for normal chemotaxis. Edits the 3' UTR of clec-41 which is required for normal clec-41 expression and for chemotaxis. Plays a role in determining lifespan. Not required for RNA interference. Likely to play a role in determining whether a dsRNA enters the RNAi pathway.


ensembl_gene_id: T20H4.5.1
symbol: T20H4.5
gene_biotype: protein_coding
description:
  Probable NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).


ensembl_gene_id: T21B10.7.2
symbol: cct-2
gene_biotype: protein_coding
description:
  T-complex protein 1 subunit beta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin; Belongs to the TCP-1 chaperonin family.


ensembl_gene_id: T21C12.1e.2
symbol: unc-49
gene_biotype: protein_coding
description:
  Ionotropic GABA receptor subunit UNC-49B.3; Belongs to the ligand-gated ion channel (TC 1.A.9) family.


ensembl_gene_id: T21C12.2.1
symbol: hpd-1
gene_biotype: protein_coding
description:
  4-hydroxyphenylpyruvate dioxygenase; Key enzyme in the degradation of tyrosine; Belongs to the 4HPPD family.


ensembl_gene_id: T21C9.12.1
symbol: scpl-4
gene_biotype: protein_coding
description:
  Mitochondrial import inner membrane translocase subunit TIM50; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane; Belongs to the TIM50 family.


ensembl_gene_id: T21C9.1b.1
symbol: mics-1
gene_biotype: protein_coding
description:
  Mitochondrial scaffolding protein 1; Plays a role in the regulation of lifespan in a partially daf-16-mediated manner, and may be involved in regulating the levels of reactive oxygen species production in response to heat stress.


ensembl_gene_id: T21C9.2a.1
symbol: vps-54
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 54; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex facilitates tethering as well as SNARE complex assembly at the Golgi.


ensembl_gene_id: T21D12.4.1
symbol: pat-6
gene_biotype: protein_coding
description:
  Paralyzed arrest at two-fold protein 6; Involved in the regulation of cell adhesion and cytoskeleton organization. Component of an integrin containing attachment complex, which is required for muscle development and maintenance. During embryonic development, required to recruit cpna-1, unc-89 and myofilaments to newly forming integrin attachments composed of integrins pat-2/pat-3, pat-4 and unc-112. Also required to reposition the integrin-based attachments so that they form the highly ordered array of dense body and M-line attachments that are characteristic of mature muscle cells. Du [...]


ensembl_gene_id: T21D12.9a.2
symbol: sma-10
gene_biotype: protein_coding
description:
  Leucine-rich repeats and immunoglobulin-like domains protein sma-10; Binds to the TGF-beta receptors sma-6 and daf-4, and enhances TGF-beta signaling activity in vitro. Has a role in regulation of body size.


ensembl_gene_id: T21E12.4a.2
symbol: dhc-1
gene_biotype: protein_coding
description:
  Dynein heavy chain, cytoplasmic; Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules (By similarity). Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity). May play a role in nuclear migration in hypodermal precursor cells. May be involved in the transport of synaptic vesicle components towards the axon of the DA motor neuron. This function may involve the regulation of dynein by pct-1 and/or cdk-5. Involved in the formation of synapses in the dorsal regi [...]


ensembl_gene_id: T21E3.1.1
symbol: egg-4
gene_biotype: protein_coding
description:
  Inactive protein-tyrosine phosphatase egg-4; Inactive phosphatase which acts redundantly with egg-5 in the oocyte-to-zygote transition. Required for the polarization of cortical actin cytoskeleton rearrangement in the oocyte before and after fertilization. Together with egg-5, required for the cortical localization of kinase mbk-2 and for the inhibition of mbk-2 kinase activity in maturing oocyte until the end of meiosis I. Also required for kinase mbk-2, pseudophosphatase egg-3 and chitin synthase chs-1 localization to cytoplasmic foci after fertilization.


ensembl_gene_id: T21G5.3.1
symbol: glh-1
gene_biotype: protein_coding
description:
  ATP-dependent RNA helicase glh-1; Probable ATP-binding RNA helicase. May act redundantly with the P-granule component glh-4 to regulate the formation of the granular structure of P-granules in embryos. May play a role in transgenerational epigenetic inheritance. May protect somatic cells from excessive apoptosis during normal development. Belongs to the DEAD box helicase family. DDX4/VASA subfamily.


ensembl_gene_id: T21G5.5d.1
symbol: asd-2
gene_biotype: protein_coding
description:
  RNA-binding protein asd-2; RNA-binding protein that binds to the 5'-NACUAAY-N(1,20)- UAAY-3' consensus sequence in pre-mRNA introns to promote alternative splicing. Required for mutually exclusive alternative splicing where it modulates the switch between mutually exclusive exons during pre-mRNA maturation. Involved in muscle-specific gene expression regulating the alternative splicing of genes such as let-2 and unc-60 to ensure that their respective isoforms are expressed in muscle. Promotes the removal of intron 10 from let-2 pre-mRNA to allow for the exclusive expression of the musc [...]


ensembl_gene_id: T21H3.3a.1
symbol: cmd-1
gene_biotype: protein_coding
description:
  Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.


ensembl_gene_id: T21H8.1h.1
symbol: hlb-1
gene_biotype: protein_coding
description:
  Liprin-beta homolog; Involved in the regulation of synaptic function at neuromuscular junctions. Together with the liprin- alpha protein syd-2, may play a role in regulating the structure of the neuronal region, called the active zone, from which synaptic vesicles send neurotransmitter signals across the synapse. Does not seem to be required for neuronal development. May regulate the disassembly of focal adhesions (By similarity). Does not bind receptor-like tyrosine phosphatases type 2A (By similarity); Belongs to the liprin family. Liprin-beta subfamily.


ensembl_gene_id: T22B11.5a.1
symbol: ogdh-1
gene_biotype: protein_coding
description:
  2-oxoglutarate dehydrogenase, mitochondrial; The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).


ensembl_gene_id: T22B7.1a.1
symbol: egl-13
gene_biotype: protein_coding
description:
  Transcription factor egl-13; Probable transcription factor that is required for uterine cell fate decisions. Controls genes required for the specification and differentiation of O(2) and CO(2)- sensing neurons and for maintaining URX sensory neuronal cell fate.


ensembl_gene_id: T22C1.10a.1
symbol: rbg-2
gene_biotype: protein_coding
description:
  Rab3 GTPase-activating protein regulatory subunit; Probable regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily. Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase- activating complex specifically converts active Rab3-GTP to the inactive form Rab3-GDP (By similarity).


ensembl_gene_id: T22C1.2.1
symbol: glb-26
gene_biotype: protein_coding
description:
  Globin-like protein 26; Plays a role in electron transport. Utilizes the bis-histidyl hexacoordinated complex with iron to transfer electrons to cytochrome c and molecular oxygen. Plays a regulatory role in the periodicity of the defecation cycle under oxidative stress conditions. Not involved in imparting protection against general conditions of oxidative stress. May participate in redox reactions under anaerobic conditions.


ensembl_gene_id: T22D1.10.1
symbol: ruvb-2
gene_biotype: protein_coding
description:
  RuvB-like 2; Possesses single-stranded DNA-stimulated ATPase and ATP- dependent DNA helicase (5' to 3') activity suggesting a role in nuclear processes such as recombination and transcription (By similarity). May participate in several chromatin remodeling complexes that mediate the ATP-dependent exchange of histones and remodel chromatin by shifting nucleosomes (By similarity). Involvement in these complexes is likely required for transcriptional activation of selected genes and DNA repair in response to DNA damage (By similarity). Has a role in gonadal development. Involved in the en [...]


ensembl_gene_id: T22D1.3a.1
symbol: T22D1.3
gene_biotype: protein_coding
description:
  Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.


ensembl_gene_id: T22D1.4.1
symbol: ribo-1
gene_biotype: protein_coding
description:
  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...]


ensembl_gene_id: T22D1.9.1
symbol: rpn-1
gene_biotype: protein_coding
description:
  26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family.


ensembl_gene_id: T22E5.2.1
symbol: glt-4
gene_biotype: protein_coding
description:
  Putative sodium-dependent excitatory amino acid transporter glt-4; Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D- aspartate. Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport.


ensembl_gene_id: T22E5.5.1
symbol: mup-2
gene_biotype: protein_coding
description:
  Troponin T; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to muscle actomyosin ATPase activity.


ensembl_gene_id: T22F3.12.1
symbol: T22F3.12
gene_biotype: protein_coding
description:
  Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.


ensembl_gene_id: T22F3.3a.1
symbol: pygl-1
gene_biotype: protein_coding
description:
  Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.


ensembl_gene_id: T22F3.4a.1
symbol: rpl-11.1
gene_biotype: protein_coding
description:
  60S ribosomal protein L11-1; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome throu [...]


ensembl_gene_id: T22G5.2.1
symbol: lbp-7
gene_biotype: protein_coding
description:
  Fatty acid-binding protein homolog 7; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.


ensembl_gene_id: T22G5.5b.1
symbol: sptl-3
gene_biotype: protein_coding
description:
  Serine palmitoyltransferase 3; Component of the serine palmitoyltransferase (SPT) that catalyzes the first committed step in sphingolipid biosynthesis, which is the condensation of an acyl-CoA species and L-serine. The catalytic core is composed of a heterodimer of sptl-1 and sptl-2 or sptl-1 and sptl-3 (By similarity). Required for the specification of abicobasal polarity and development of the gut lumen; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.


ensembl_gene_id: T22G5.6.1
symbol: lbp-8
gene_biotype: protein_coding
description:
  FABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.


ensembl_gene_id: T22H6.1.1
symbol: ilc-17.1
gene_biotype: protein_coding
description:
  Interleukin cytokine-related protein 17.1; Ligand for the receptor complex composed of ilcr-1 and ilcr- 2. Binding to the ilcr-1/2 receptor complex triggers a signaling cascade, activating the downsteam signaling components actl-1, pik-1 and nfki-1, and results in increased neuronal activity in RMG interneurons in response to input from oxygen-sensing neurons. This leads to increased animal movement and promotes aggregation behavior. Plays a role in the responsiveness of RMG interneurons to ascaroside pheromones; Belongs to the IL-17 family.


ensembl_gene_id: T22H6.2b.1
symbol: alh-13
gene_biotype: protein_coding
description:
  Probable delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.


ensembl_gene_id: T22H9.2a.1
symbol: atg-9
gene_biotype: protein_coding
description:
  Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.


ensembl_gene_id: T23C6.1.1
symbol: mdt-1.2
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 1.2; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).


ensembl_gene_id: T23D8.1b.1
symbol: mom-5
gene_biotype: protein_coding
description:
  Protein mom-5; Receptor for Wnt proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of gsk-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (Probable). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as pkc seems to be required for Wnt-mediated inactivation of gsk-3 kinase (Probable). B [...]


ensembl_gene_id: T23D8.4.1
symbol: eif-3.C
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 3 subunit C; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.


ensembl_gene_id: T23D8.8.1
symbol: cfi-1
gene_biotype: protein_coding
description:
  AT-rich interactive domain-containing protein cfi-1; Transcription factor which regulates neuronal subtype identity. Promotes differentiation of URA sensory neurons and prevents them to express male-specific CEM features. Promotes differentiation of AVD and PVC interneurons and their glutamate receptor expression.


ensembl_gene_id: T23F1.7b.1
symbol: dpf-1
gene_biotype: protein_coding
description:
  Dipeptidyl peptidase family member 1; Removes N-terminal dipeptides sequentially from polypeptides (By similarity). Essential for control of distal tip cell migration.


ensembl_gene_id: T23F11.3b.2
symbol: cdka-1
gene_biotype: protein_coding
description:
  Cyclin-dependent kinase 5 activator 1; Activator of the kinase cdk-5 (By similarity). In several motor neurons, promotes the polarized trafficking of synaptic vesicles and dense-core vesicles. In the ventral nerve cord, regulates the synaptic localization of the glutamate receptor, glr-1. In DA motor neurons, regulates axonal transport of synaptic vesicle precursors by inhibiting dynein-mediated retrograde transport. Regulates the polarized distribution of dense-core vesicles in DB motor neurons. May regulate these processes in association with cdk-5. May also play a role in GABAergic  [...]


ensembl_gene_id: T23G11.3.1
symbol: gld-1
gene_biotype: protein_coding
description:
  Female germline-specific tumor suppressor gld-1; RNA-binding protein which recognizes the 5'-UACUCAU-3' RNA consensus sequence. Binds sequences in both the 5'coding and the 3'-UTR region of rme-2 mRNA. Binds sequences in the 3'-UTR region of cye-1 mRNA. Binds to cyb-2.1, cyb-2.2 and cyb-3 mRNA. Binds sequences in the 3'-UTR region of tra-2 mRNA. Germ line-specific tumor suppressor essential for oogenesis. Controls the spatial pattern of translation of multiple oogenesis specific mRNAs (e.g. yolk receptor rme-2) by repression of translation during early meiotic prophase (leptotene to pa [...]


ensembl_gene_id: T23G5.1.2
symbol: rnr-1
gene_biotype: protein_coding
description:
  Ribonucleoside-diphosphate reductase large subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.


ensembl_gene_id: T23G5.5.1
symbol: dat-1
gene_biotype: protein_coding
description:
  Sodium-dependent dopamine transporter; Dopamine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals.


ensembl_gene_id: T23G5.6.1
symbol: saeg-2
gene_biotype: protein_coding
description:
  Suppressor of activated egl-4 protein 2; As a likely component of a histone deacetylase complex, together with saeg-1 and hda-2, functions downstream of the cAMP- dependent kinase egl-4 to regulate the expression of genes required for egg-laying and foraging.


ensembl_gene_id: T23G7.1.1
symbol: dpl-1
gene_biotype: protein_coding
description:
  Transcription factor dpl-1; Synthetic multivulva class B (synMuvB) protein. SynMuvB proteins are required to repress the induction of vulval development by Ras signaling and probably act by forming the multiprotein DRM complex that represses transcription. May also negatively regulate vulval development in association with other SynMuv class B proteins such as lin-15A. Can stimulate E2F-dependent transcription. Plays a role in negatively regulating the progression through the G1 phase of the cell cycle during postembryonic development, most likely by acting as a transcriptional repress [...]


ensembl_gene_id: T23G7.4.1
symbol: sec-5
gene_biotype: protein_coding
description:
  Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family.


ensembl_gene_id: T23G7.5a.1
symbol: pir-1
gene_biotype: protein_coding
description:
  RNA/RNP complex-1-interacting phosphatase homolog; Possesses RNA 5'-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosine phosphatase activity (By similarity). Binds RNA (By similarity). During small-RNA-mediated gene- silencing or RNA interference (RNAi), involved in the dcr-1-mediated processing of an amplified dsRNA intermediate.


ensembl_gene_id: T23H2.5.2
symbol: rab-10
gene_biotype: protein_coding
description:
  Ras-related protein Rab-10; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for basolateral endocytic recycling, the return of macromolecules and fluid from endosomes to the plasma membrane, in polarized epithelial cells of the intestine upstream of rm [...]


ensembl_gene_id: T24A11.1a.1
symbol: mtm-3
gene_biotype: protein_coding
description:
  Myotubularin-related protein 3; Preferentially dephosphorylates phosphatidylinositol 3- phosphate (PI3P), and has some activity towards phosphatidylinositol 3,5-bisphosphate (PI35P). May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues (By similarity). Positively regulates autophagy and is recruited to autophagosomes by PI3P where it catalyzes PI3P turnover to promote autophagosome maturation. Thought to have a role in maintenance of muscle function. Involved in locomotion and lifespan determination.


ensembl_gene_id: T24B8.6.1
symbol: hlh-3
gene_biotype: protein_coding
description:
  Helix-loop-helix protein 3; Probable transcriptional regulator. May mediate transcriptional activation by binding to the E-box motif 5'-CANNTG-3'. Plays a role in the differentiation of the hermaphrodite-specific motor neurons (HSN) that are required for normal egg laying. Might play a role in serotonin production by regulating expression of the tryptophan hydrolase tph-1 which catalyzes serotonin synthesis, in the HSN neurons. Also plays a role in HSN axon guidance towards the vulva and the ventral nerve cord, possibly by promoting the expression of the netrin receptor unc-40. Under f [...]


ensembl_gene_id: T24C12.2.1
symbol: gap-1
gene_biotype: protein_coding
description:
  Ras GTPase-activating protein gap-1; GTPase-activating protein, which inhibits the vulval induction by acting as a negative regulator for the member of the Ras family let-60. Probably decreases the signaling activity of Ras by stimulating its intrinsic GTPase activity, thereby lowering the levels of GTP-bound, active Ras.


ensembl_gene_id: T24C4.6b.1
symbol: zer-1
gene_biotype: protein_coding
description:
  Zyg eleven-related protein 1; Acts as target recruitment subunit in the E3 ubiquitin ligase complex zer-1-cul-2-elc-1.


ensembl_gene_id: T24D1.1c.1
symbol: sqv-5
gene_biotype: protein_coding
description:
  Chondroitin sulfate synthase sqv-5; Has both beta-1,3-glucuronic acid and beta-1,4-N- acetylgalactosamine transferase activity. The beta- 1,3-glucuronic acid transferase activity is controversial as it is not detected using the purified recombinant enzyme. Adds the first N-acetylgalactosamine(GalNAc) to initiate the chondroitin chain. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and GalNAc from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Together with mig-22, required for chondroitin synthesis. Plays a role in early embryonic development by controlling [...]


ensembl_gene_id: T24F1.2.1
symbol: samp-1
gene_biotype: protein_coding
description:
  Transmembrane protein 201 homolog; Plays a role in nuclear migration in hypodermal cells. Belongs to the TMEM201 family.


ensembl_gene_id: T24H10.1.1
symbol: T24H10.1
gene_biotype: protein_coding
description:
  Putative transcription elongation factor S-II; Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus (By similarity). Belongs to the TFS-II family.


ensembl_gene_id: T24H10.7a.1
symbol: jun-1
gene_biotype: protein_coding
description:
  Transcription factor jun-1; Transcription factor that recognizes and binds to the AP-1 non-canonical enhancer heptamer motif 5'-TTAGTCA-3'. Required for ovulation. Controls plc-1 expression in the spermatheca to regulate spermathecal valve dilation.


ensembl_gene_id: T24H7.1.2
symbol: phb-2
gene_biotype: protein_coding
description:
  Mitochondrial prohibitin complex protein 2; PHB proteins are essential during embryonic development and are required for somatic and germline differentiation in the larval gonad. A deficiency in PHB proteins results in altered mitochondrial biogenesis in body wall muscle cells.


ensembl_gene_id: T24H7.4.1
symbol: blos-4
gene_biotype: protein_coding
description:
  Biogenesis of lysosome-related organelles complex 1 subunit 4; Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in gut granule biogenesis. Belongs to the BLOC1S4 family.


ensembl_gene_id: T25B9.9.1
symbol: T25B9.9
gene_biotype: protein_coding
description:
  6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.


ensembl_gene_id: T25C12.1a.1
symbol: lin-14
gene_biotype: protein_coding
description:
  Protein lin-14; Heterochronic protein which controls the choice of stage specific cell fates. Involved in the temporal progression of vulval fate patterning, possibly by inhibiting lin-12. Acts as a transcription factor involved in the stage-specific repression of insulin/insulin- like growth factor gene ins-33. Isoform A may be involved in specifying L1 cell fates while isoform B1 and isoform B2 may specify L2 and later cell fates, creating a temporal switch.


ensembl_gene_id: T25E12.4f.1
symbol: dkf-2
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase dkf-2; Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Acts in the intestine to regulate both innate immunity by promoting activation of PMK-1 and also stress response and life span by acting as an upstream, negative regulator of the daf-16 transcription factor. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.


ensembl_gene_id: T25F10.5.1
symbol: bbs-8
gene_biotype: protein_coding
description:
  Tetratricopeptide repeat protein 8; Component of the BBSome complex (By similarity). The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia (By similarity). The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function (By similarity). Required for proper BBSome complex assembly and its ciliary localization. Required for cilia biogenesis and both the assembly and movement of intraflagellar transport proteins along the ciliary axoneme. Plays a role in guanylyl cyclase loca [...]


ensembl_gene_id: T25G12.4.1
symbol: rab-6.2
gene_biotype: protein_coding
description:
  Ras-related protein Rab-6.2; Protein transport. Probably involved in vesicular traffic (By similarity).


ensembl_gene_id: T25G3.2.1
symbol: chs-1
gene_biotype: protein_coding
description:
  Chitin synthase chs-1; Essential for the embryonic synthesis of chitin, a component of the eggshell.


ensembl_gene_id: T25G3.3.1
symbol: T25G3.3
gene_biotype: protein_coding
description:
  60S ribosomal export protein NMD3; Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit; Belongs to the NMD3 family.


ensembl_gene_id: T26A5.5a.1
symbol: jhdm-1
gene_biotype: protein_coding
description:
  JmjC domain-containing histone demethylation protein 1; Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code (By similarity). Has a role in regulating lifespan.


ensembl_gene_id: T26A5.7a.1
symbol: set-1
gene_biotype: protein_coding
description:
  Histone-lysine N-methyltransferase set-1; Histone methyltransferase that specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched on hermaphrodite X chromosomes and during mitosis. Involved in dosage compensation by repression of X-linked gene expression in hermaphrodites. Plays a role in growth and body fat regulation downstream of the TOR complex 2 pathway. Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. PR/SET subfamily.


ensembl_gene_id: T26A5.9.3
symbol: dlc-1
gene_biotype: protein_coding
description:
  Dynein light chain 1, cytoplasmic; Acts as a non-catalytic accessory component of a dynein complex (By similarity). Part of a complex with bicd-1 and egal-1, which is recruited to the nuclear envelope by unc-83, where in turn, it recruits dynein to the nuclear surface and regulates nuclear migrations in hypodermal precursor cells. Probably within a dynein motor complex, plays a role in the cell fate specification of the germline and oogenesis. In particular, it inhibits germ cell proliferation. Regulates the function and localization of the RNA-binding protein fbf- 2 in the germline. P [...]


ensembl_gene_id: T26C11.6.1
symbol: ceh-21
gene_biotype: protein_coding
description:
  Homeobox protein ceh-21; Probable DNA-binding regulatory protein involved in cell-fate specification; Belongs to the CUT homeobox family.


ensembl_gene_id: T26C11.7.2
symbol: ceh-39
gene_biotype: protein_coding
description:
  Homeobox protein ceh-39; Probable DNA-binding regulatory protein involved in cell-fate specification; Belongs to the CUT homeobox family.


ensembl_gene_id: T26C12.4.1
symbol: gcy-23
gene_biotype: protein_coding
description:
  Receptor-type guanylate cyclase gcy-23; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Regulates thermotaxis responses in AFD sensory neurons. May regulate AFD neuronal activity such as calcium responses to temperature gradients.


ensembl_gene_id: T26E3.2.1
symbol: ndx-1
gene_biotype: protein_coding
description:
  Putative nudix hydrolase 1; Probably mediates the hydrolysis of some nucleoside diphosphate derivatives; Belongs to the Nudix hydrolase family.


ensembl_gene_id: T26E3.3a.1
symbol: par-6
gene_biotype: protein_coding
description:
  Partitioning defective protein 6; Necessary for apicobasal and anterior-posterior asymmetries associated with cell adhesion and gastrulation during the first few cell cycles of embryogenesis. Required for localizing/ maintaining par-3 at the cell periphery. Regulates mes-1 expression and/or localization pattern during early embryogenesis. Acts together with par-3 and pkc-3 in maintaining epithelial cell polarity in the distal spermatheca. Plays a role in endosome and Golgi body positioning. Belongs to the PAR6 family.


ensembl_gene_id: T26G10.1.1
symbol: T26G10.1
gene_biotype: protein_coding
description:
  Putative ATP-dependent RNA helicase T26G10.1; Probable ATP-dependent RNA helicase which may be involved in ribosome biogenesis.


ensembl_gene_id: T26H10.1b.1
symbol: des-2
gene_biotype: protein_coding
description:
  Acetylcholine receptor subunit alpha-type des-2; Subunit of the non-synaptic neuronal acetylcholine receptor (AChR), which may play a role in chemotaxis towards choline. After binding choline or acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.


ensembl_gene_id: T26H2.9a.1
symbol: nhr-79
gene_biotype: protein_coding
description:
  Nuclear hormone receptor family member nhr-79; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family.


ensembl_gene_id: T27A3.6.1
symbol: nmrk-1
gene_biotype: protein_coding
description:
  Molybdopterin synthase catalytic subunit; Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.


ensembl_gene_id: T27B1.1.1
symbol: osm-1
gene_biotype: protein_coding
description:
  Intraflagellar transport protein osm-1; Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. May be required for ciliary entrance and transport of specific ciliary cargo proteins such as che-3 which are related to motility. Required for the maintenance and formation of chemosensory cilia that detect chemosensory cues.


ensembl_gene_id: T27B7.1a.1
symbol: nhr-59
gene_biotype: protein_coding
description:
  Nuclear hormone receptor family member nhr-59; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family.


ensembl_gene_id: T27B7.4a.1
symbol: nhr-115
gene_biotype: protein_coding
description:
  Nuclear hormone receptor family member nhr-115; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family.


ensembl_gene_id: T27C10.6.1
symbol: lrk-1
gene_biotype: protein_coding
description:
  Leucine-rich repeat serine/threonine-protein kinase 1; Determines polarized sorting of synaptic vesicle (SV) proteins to the axons by excluding SV proteins from the dendrite- specific transport machinery in the Golgi. Role in stress response. Appears to antagonize the effects of pink-1 both in the regulation of axon guidance and stress response; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily.


ensembl_gene_id: T27D1.1.1
symbol: cyn-9
gene_biotype: protein_coding
description:
  Peptidyl-prolyl cis-trans isomerase 9; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Thought to function as a catalyst in the folding and modification of cuticle collagens.


ensembl_gene_id: T27D1.3.1
symbol: npr-15
gene_biotype: protein_coding
description:
  Neuropeptide receptor 15; Probable receptor for neuropeptide ligand nlp-8 that plays a role in octopamine signaling and specifically, the octopamine inhibition of aversion responses in olfactory sensory neurons. Belongs to the G-protein coupled receptor 1 family.


ensembl_gene_id: T27E9.2.1
symbol: T27E9.2
gene_biotype: protein_coding
description:
  Cytochrome b-c1 complex subunit 6; This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1. Belongs to the UQCRH/QCR6 family.


ensembl_gene_id: T27E9.3.1
symbol: cdk-5
gene_biotype: protein_coding
description:
  Cyclin-dependent-like kinase 5; Proline-directed serine/threonine-protein kinase which, in several motor neurons, promotes the polarized trafficking of synaptic vesicles and dense-core vesicles (DCV). In the ventral nerve cord, phosphorylates lin-10 and thereby prevents lin-10-mediated anterograde trafficking of the glutamate receptor glr-1. Involved in the inhibition of glr-1 trafficking in hypoxic conditions. In DA motor neurons but not in DB motor neurons, regulates axonal transport of synaptic vesicle precursors by inhibiting dynein-mediated retrograde transport. Regulates the traf [...]


ensembl_gene_id: T27E9.9.1
symbol: acc-4
gene_biotype: protein_coding
description:
  Acetylcholine-gated ion channel acc-4; Probable acetylcholine-gated chloride channel subunit. Does not have ion channel activity alone as a homopentamer, but forms a functional heteropentameric ion channel with acc-1. May function with lgc-46 to regulate synaptic transmission and synaptic vesicle release in response to acetylcholine in cholinergic motor neurons.


ensembl_gene_id: T27F2.3.1
symbol: bir-1
gene_biotype: protein_coding
description:
  Chromosomal passenger complex protein bir-1; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of chromosome segregation and cytokinesis. The CPC complex has essential functions at the centromere in ensuring correct chromosome condensation, alignment and segregation. In the complex, required to direct the Aurora B/air-2 kinase to chromosomes. Also functions in spindle midzone formation and in the formation of polar bodies during oogenesis. Required for the localization of the kinetochore component hcp-1 to chromosomes. Involved in the positive [...]


ensembl_gene_id: T27F2.4.1
symbol: zip-10
gene_biotype: protein_coding
description:
  Transcription factor zip-10; Transcription factor that regulates the expression of genes in response to changes in temperature. In particular, binds to the promoter region of genes such as asp-17 in response to severe cold to warm temperature transitions to promote gene expression. Promotes stress-induced death, particularly in older animals, following cold shock followed by warming and this may have evolved as a form of kin survival under thermal stress conditions, favoring the survival of younger animals.


ensembl_gene_id: T28D6.9.1
symbol: pen-2
gene_biotype: protein_coding
description:
  Gamma-secretase subunit pen-2; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch (glp-1 or lin-12). It may represent a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Belongs to the PEN-2 family.


ensembl_gene_id: T28D9.10a.1
symbol: snr-3
gene_biotype: protein_coding
description:
  Probable small nuclear ribonucleoprotein Sm D1; Essential for pre-mRNA splicing. Implicated in the formation of stable, biologically active snRNP structures (By similarity). Belongs to the snRNP core protein family.


ensembl_gene_id: T28D9.2a.1
symbol: rsp-5
gene_biotype: protein_coding
description:
  Probable splicing factor, arginine/serine-rich 5; Plays a functionally redundant role in shifting germ cell sexual differentiation in hermaphrodites.


ensembl_gene_id: T28F12.2a.2
symbol: unc-62
gene_biotype: protein_coding
description:
  Homeobox protein unc-62; Acts redundantly with ceh-20 and ceh-40 to perform overlapping roles during embryogenesis. Required for postembryonic development of the ectoderm, including the Q, V and P cell lineages, playing a crucial role in ensuring that these cells and their descendants undergo their invariant patterns of cell division, migration, fusion and morphogenesis. Has a role in the mig-13 pathway to promote anterior migration of neuroblasts in the Q lineage. Required for multiple roles in regulating vulva development. Belongs to the TALE/MEIS homeobox family.


ensembl_gene_id: T28F12.3.1
symbol: sos-1
gene_biotype: protein_coding
description:
  Son of sevenless homolog; Promotes the exchange of Ras-bound GDP by GTP (By similarity). May regulate signaling pathways downstream of receptor tyrosine kinase, egl-15 and let-23. Required for larval and male spicule development, fluid homeostasis, vulva induction, spermatogenesis, and oogenesis by promoting meiosis prophase exit during oocyte maturation. Required for the delamination of G1 cell by promoting the loss of cell junctions and detachment from the excretory system during larval development. Plays a role in nicotinic acetylcholine receptor (nAChR)-mediated sensitivity to nico [...]


ensembl_gene_id: T28F2.4a.1
symbol: jmjc-1
gene_biotype: protein_coding
description:
  Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys- 4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code (By similarity). Mediates response to multiple stress stimuli, including heat shock and osmotic, oxidative, and ethanol stress; Belongs to the ROX family. NO66 subfamily.


ensembl_gene_id: T28F3.1a.1
symbol: nra-1
gene_biotype: protein_coding
description:
  Nicotinic receptor-associated protein 1; Exhibits calcium-dependent phospholipid binding properties (By similarity). May function in membrane trafficking. Regulates synaptic levels of nicotinic acetylcholine receptor subunit lev-1 and unc-38 in the nerve cord. Involved in nicotinic acetylcholine receptor (nAChR)-mediated sensitivity to nicotine and levamisole. Affects directional sperm motility.


ensembl_gene_id: T28F3.3.1
symbol: zipt-7.1
gene_biotype: protein_coding
description:
  Zinc transporter zipt-7.1; Zinc transporter which regulates intracellular zinc levels. Required for spermatogenesis in both hermaphrodites and males where it resides in an inactive form in immature sperm, spermatids, but is likely activated in response to reduced spe-4 and spe-6 function. Upon activation, mediates the release of zinc from internal stores in spermatids into the cytoplasm. The resulting increase in cytoplasmic zinc levels promotes spermatid activation and subsequent differentiation into mature motile sperm that are capable of fertilization.


ensembl_gene_id: T28F3.6.1
symbol: ifta-2
gene_biotype: protein_coding
description:
  Intraflagellar transport associated protein 2; Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. May be required for ciliary entrance and transport of specific ciliary cargo proteins such as che-3 which are related to motility. Regulates specific signaling activities in the cilia, such as the daf-2/insulin receptor-like transduction pathway.


ensembl_gene_id: VC5.4.1
symbol: mys-1
gene_biotype: protein_coding
description:
  Histone acetyltransferase Tip60 homolog; Probable catalytic subunit of the Tip60 chromatin-remodeling complex. May acetylate nucleosomal histone H4 and H2A. Acts in the determination of vulval and distal tip cell (DTC) precursor cell fates. Belongs to the MYST (SAS/MOZ) family.


ensembl_gene_id: VF36H2L.1.1
symbol: aph-1
gene_biotype: protein_coding
description:
  Gamma-secretase subunit aph-1; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors (lin-12 or glp-1). It may represent a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Required for the localization of aph-2.


ensembl_gene_id: VW02B12L.4.1
symbol: adbp-1
gene_biotype: protein_coding
description:
  Adr-2-binding protein 1; Required for the A-I editing activity of the double-stranded RNA-specific adenosine deaminase adr-2 by facilitating adr-2 nuclear localization.


ensembl_gene_id: VZK822L.1a.2
symbol: fat-6
gene_biotype: protein_coding
description:
  Delta(9)-fatty-acid desaturase fat-6; Delta(9)-fatty-acid desaturase that acts preferentially on stearoyl-CoA. Also acts on vaccenyl-coA and heptadecanyol-CoA. Belongs to the fatty acid desaturase type 1 family.


ensembl_gene_id: W01A11.3a.1
symbol: unc-83
gene_biotype: protein_coding
description:
  Nuclear migration protein unc-83; Cargo-specific adapter that is involved in nuclear migration during development and thereafter. Component of the unc-83-unc-84 LINC (LInker of Nucleoskeleton and Cytoskeleton) complex where it interacts with unc-84 to form a bridge connecting the nuclear envelope to the cytoskeleton which allows for nuclear transport along microtubules. Within the complex, connects the nuclear envelope to the microtubule cytoskeleton through the kinesin-1 light chain protein klc-2 (most likely within the Kinesin 1 motor complex) to regulate nuclear migrations. Moreover [...]


ensembl_gene_id: W01A8.1c.2
symbol: plin-1
gene_biotype: protein_coding
description:
  Perilipin-1 homolog; Lipid droplet-associated protein which plays a role in lipid droplet clustering. Belongs to the perilipin family.


ensembl_gene_id: W01B6.1.1
symbol: cwn-2
gene_biotype: protein_coding
description:
  Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Involved in the correct positioning of the developing nerve ring and in axon guidance of SIA and SIB neurons, probably by binding to tyrosine kinase receptor cam-1. In addition, regulates the positioning of some head neuronal cells, muscle arms associated with the nerve ring and the excretory pore. Together with Wnt ligand cwn- [...]


ensembl_gene_id: W01B6.7.1
symbol: col-2
gene_biotype: protein_coding
description:
  Cuticle collagen 2; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.


ensembl_gene_id: W01B6.9.1
symbol: ndc-80
gene_biotype: protein_coding
description:
  Kinetochore protein ndc-80; Acts as a component of the essential kinetochore-associated ndc-80 complex, which is required for chromosome segregation in mitosis and meiosis and spindle checkpoint activity. Plays a role in kinetochore assembly and recruits the checkpoint protein mdf-2 and the spindly-like protein spdl-1 to unattached kinetochores. Mediates the formation of end-on kinetochore-microtubule attachments through recruitment of spdl-1. The ndc-80 complex synergistically enhances the affinity of the ska-1 complex for microtubules and may allow the ndc-80 complex to track depolym [...]


ensembl_gene_id: W01C9.4.1
symbol: decr-1.2
gene_biotype: protein_coding
description:
  Probable 2,4-dienoyl-CoA reductase decr-1.2; Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily.


ensembl_gene_id: W01D2.5a.2
symbol: osta-3
gene_biotype: protein_coding
description:
  Organic solute transporter alpha-like protein 3; Probable transporter; Belongs to the OST-alpha family.


ensembl_gene_id: W01G7.3.2
symbol: rpb-11
gene_biotype: protein_coding
description:
  Probable DNA-directed RNA polymerase II subunit RPB11; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft (By similarity).


ensembl_gene_id: W01G7.5.1
symbol: lem-2
gene_biotype: protein_coding
description:
  LEM protein 2; Essential protein involved in chromosome segregation and cell division, probably via its interaction with lmn-1, the main component of nuclear lamina. Has some overlapping function with emr-1. May play a role in radiation-induced DNA damage repair response.


ensembl_gene_id: W02A11.1.2
symbol: W02A11.1
gene_biotype: protein_coding
description:
  tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A; Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.


ensembl_gene_id: W02A11.4.1
symbol: uba-2
gene_biotype: protein_coding
description:
  SUMO-activating enzyme subunit uba-2; The dimeric enzyme acts as an E1 ligase for smo-1. It mediates ATP-dependent activation of smo-1 and formation of a thioester with a conserved cysteine residue on uba-2 (Probable).


ensembl_gene_id: W02A2.1a.2
symbol: fat-2
gene_biotype: protein_coding
description:
  Delta(12) fatty acid desaturase fat-2; Catalyzes the desaturation of oleic acid (Delta(9)-18:1, or C18:1(n-9)) to linoleic acid (Delta(9,12)-18:2, or C18:2(n-6)). This desaturation event is essential for the synthesis of longer chain polyunsaturated fatty acids (PUFAs) such as arachidonic acid (AA, or C20:4(n-6)) and eicosapentaenoic acid (EPA, or C20:5(n-3)).


ensembl_gene_id: W02A2.6a.1
symbol: rec-8
gene_biotype: protein_coding
description:
  Meiotic recombination protein rec-8; Plays a role in meiotic chromosome cohesion and segregation. Necessary for sister chromatid co- orientation and sister chromatid cohension until meiosis II. May also be required for repair of programmed meiotic double stranded breaks. During spermatogenesis, likely involved in spermatocyte centriole cohesion, thus preventing their separation during the second meiotic division. Belongs to the rad21 family. Highly divergent.


ensembl_gene_id: W02A2.7.1
symbol: mex-5
gene_biotype: protein_coding
description:
  Zinc finger protein mex-5; Functions with mex-6 to affect embryonic viability, establish soma germline asymmetry in embryos and establish plk-1, pie-1, mex-1, and pos-1 asymmetry in embryos. Also affects formation of intestinal cells. Binds to mRNA in vitro, and inhibits pgl-3-mediated P-granule formation, probably by competing with pgl-3 for binding to mRNA.


ensembl_gene_id: W02B12.10.1
symbol: W02B12.10
gene_biotype: protein_coding
description:
  tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.


ensembl_gene_id: W02B12.2.1
symbol: rsp-2
gene_biotype: protein_coding
description:
  Probable splicing factor, arginine/serine-rich 2; Plays a functionally redundant role in spermatogenesis and growth rate control. Required for the development of somatic gonad structures and for progression from larval stage to adulthood. Belongs to the splicing factor SR family.


ensembl_gene_id: W02B12.3a.1
symbol: rsp-1
gene_biotype: protein_coding
description:
  Probable splicing factor, arginine/serine-rich 1; Plays a functionally redundant role in spermatogenesis and growth rate control.


ensembl_gene_id: W02B12.6a.1
symbol: aars-1
gene_biotype: protein_coding
description:
  Alanine--tRNA ligase, mitochondrial; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family.


ensembl_gene_id: W02B12.9.1
symbol: mfn-1
gene_biotype: protein_coding
description:
  Mitoferrin; Mitochondrial iron transporter that mediates iron uptake. Probably required for heme synthesis of hemoproteins and Fe-S cluster assembly; Belongs to the mitochondrial carrier (TC 2.A.29) family.


ensembl_gene_id: W02B3.2.1
symbol: grk-2
gene_biotype: protein_coding
description:
  G protein-coupled receptor kinase 2; Specifically phosphorylates the activated forms of G protein- coupled receptors (By similarity). Required in adult sensory neurons for chemotaxis. Plays a role in the ASH sensory neurons in the chemotaxis response to NaCl where it is likely to modulate the strength of the NaCl avoidance response which occurs at high NaCl concentrations. Required in the HSN motor neurons for normal egg laying by promoting phosphorylation of amine oxidase amx-2 which inhibits amx-2 activity, preventing metabolism of serotonin. Acts in head acetylcholine neurons to pos [...]


ensembl_gene_id: W02B9.1b.1
symbol: hmr-1
gene_biotype: protein_coding
description:
  Cadherin-related hmr-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Required for adherens junction assembly and connecting adherens junctions to the cytoskeleton. Isoform b is involved in axonal guidance in a subset of motor neurons.


ensembl_gene_id: W02D3.2.1
symbol: dhod-1
gene_biotype: protein_coding
description:
  Dihydroorotate dehydrogenase (quinone), mitochondrial; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.


ensembl_gene_id: W02D3.3.2
symbol: mec-6
gene_biotype: protein_coding
description:
  Mechanosensory abnormality protein 6; Probable touch-cell sodium channel subunit. May be needed for mechanosensory transduction (touch sensitivity). Interacts with degenerin channel proteins and stabilizes the channel. Non-voltage- gated amiloride-sensitive cation channel permeable for sodium, potassium, lithium and N-methylglucamine. Belongs to the paraoxonase family.


ensembl_gene_id: W02D3.7.1
symbol: lbp-5
gene_biotype: protein_coding
description:
  Fatty acid-binding protein homolog 5; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.


ensembl_gene_id: W02D3.9.2
symbol: unc-37
gene_biotype: protein_coding
description:
  Transcription factor unc-37; Transcriptional corepressor that functions with the neural specificity gene unc-4 to govern motor neuron identity. May function with transcription factor mls-1 to promote uterine muscle specification and formation.


ensembl_gene_id: W02D7.7.1
symbol: sel-9
gene_biotype: protein_coding
description:
  Suppressor/enhancer of lin-12 protein 9; May have a role in the negative regulation of lin-12 and glp- 1 transport to the cell surface. May also have a role in a quality control mechanism for endoplasmic reticulum-Golgi transport; the budding of coatomer-coated and other species of coated vesicles, could bind cargo molecules to collect them into budding vesicles. Involved in regulating the expression of proteasomal subunits such as rpt-3 in order to confer resistance to proteasomal dysfunction. Belongs to the EMP24/GP25L family.


ensembl_gene_id: W02D9.1a.2
symbol: pri-2
gene_biotype: protein_coding
description:
  DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.


ensembl_gene_id: W02F12.2.1
symbol: W02F12.2
gene_biotype: protein_coding
description:
  Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid; Belongs to the alkaline ceramidase family.


ensembl_gene_id: W02G9.1.1
symbol: ndx-2
gene_biotype: protein_coding
description:
  Putative nudix hydrolase 2; Probably mediates the hydrolysis of some nucleoside diphosphate derivatives; Belongs to the Nudix hydrolase family.


ensembl_gene_id: W02G9.2b.1
symbol: kel-8
gene_biotype: protein_coding
description:
  Kelch-like protein 8; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates degradation of glutamate receptors in neurons. The BCR(kel-8) ubiquitin ligase complex mediates ubiquitination and subsequent degradation of rpy-1. Indirectly regulates the protein turnover of glr-1, possibly via ubiquitination and degradation of rpy-1.


ensembl_gene_id: W03A3.1.1
symbol: ceh-10
gene_biotype: protein_coding
description:
  Homeobox protein ceh-10; Required for larval development and for cell fate specification and migration of CAN neurons.


ensembl_gene_id: W03A3.2.1
symbol: polq-1
gene_biotype: protein_coding
description:
  DNA polymerase theta; DNA polymerase that promotes microhomology-mediated end- joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery triggered in response to double-strand breaks in DNA. MMEJ is an error-prone repair pathway that produces deletions of sequences from the strand being repaired and promotes genomic rearrangements, such as telomere fusions. Required to prevent extensive loss of sequences near G-quadruplex (G4) DNA sites, which are prone to cause genome alterations, by generating deletions.


ensembl_gene_id: W03D2.4.1
symbol: pcn-1
gene_biotype: protein_coding
description:
  Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.


ensembl_gene_id: W03D2.5a.1
symbol: wrt-5
gene_biotype: protein_coding
description:
  Warthog protein 5; Intercellular signal essential for a variety of patterning events during development.


ensembl_gene_id: W03D2.7.1
symbol: ilys-6
gene_biotype: protein_coding
description:
  Invertebrate-type lysozyme 6; Has bacteriolytic activity against Gram-positive bacteria. Belongs to the glycosyl hydrolase 22 family. Type-I lysozyme subfamily.


ensembl_gene_id: W03F11.2a.1
symbol: gcy-17
gene_biotype: protein_coding
description:
  Receptor-type guanylate cyclase gcy-17; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity); Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.


ensembl_gene_id: W03F8.1.2
symbol: tni-4
gene_biotype: protein_coding
description:
  Troponin I 4; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to muscle actomyosin ATPase activity.


ensembl_gene_id: W03F8.3a.1
symbol: W03F8.3
gene_biotype: protein_coding
description:
  Probable peptide chain release factor 1, mitochondrial; Mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain termination codons UAA and UAG.


ensembl_gene_id: W03F9.5.1
symbol: ttb-1
gene_biotype: protein_coding
description:
  Transcription initiation factor IIB; General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II.


ensembl_gene_id: W03G1.6c.1
symbol: pig-1
gene_biotype: protein_coding
description:
  Maternal embryonic leucine zipper kinase; Serine/threonine-protein kinase involved in cell autonomous neuroblast asymmetric divisions that generate one precursor cell and one apoptotic cell by controlling spindle positioning, myosin distribution and the segregation of cell fate determinants. Promotes cell shedding during embryogenesis, probably through the endocytosis-mediated removal of cell adhesion molecules such as hmp-1 from the cell surface. May act downstream of par-4/strd-1/mop-25 to regulate cell shedding.


ensembl_gene_id: W03G1.7a.1
symbol: asm-3
gene_biotype: protein_coding
description:
  Putative sphingomyelin phosphodiesterase asm-3; Converts sphingomyelin to ceramide. Belongs to the acid sphingomyelinase family.


ensembl_gene_id: W03G11.3.1
symbol: W03G11.3
gene_biotype: protein_coding
description:
  Putative alpha-L-fucosidase; Alpha-L-fucosidase is responsible for hydrolyzing the alpha- 1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins; Belongs to the glycosyl hydrolase 29 family.


ensembl_gene_id: W03G9.4.1
symbol: app-1
gene_biotype: protein_coding
description:
  Xaa-Pro aminopeptidase app-1; Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro. Has activity towards the flp-9 neuropeptide KPSFVRF- amide.


ensembl_gene_id: W03H9.4a.2
symbol: cacn-1
gene_biotype: protein_coding
description:
  Cactin; Plays a role during early embryonic development. Required for the distal tip cell migration at the end of larval development and for gonad morphogenesis.


ensembl_gene_id: W04A8.7.1
symbol: taf-1
gene_biotype: protein_coding
description:
  Transcription initiation factor TFIID subunit 1; Component of general transcription factor TFIID which establishes the initiation site for mRNA transcription (By similarity). May regulate RNA polymerase II activity and thereby may control transcription initiation by RNA polymerase II. Required for early embryonic development. Essential for embryonic transcription of several genes.


ensembl_gene_id: W04C9.2.1
symbol: W04C9.2
gene_biotype: protein_coding
description:
  MICOS complex subunit MIC13; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.


ensembl_gene_id: W05B10.1.1
symbol: his-74
gene_biotype: protein_coding
description:
  Histone H3.3-like type 2; Putative variant histone H3 which may replace conventional H3 in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).


ensembl_gene_id: W05H7.3.1
symbol: sedl-1
gene_biotype: protein_coding
description:
  Probable trafficking protein particle complex subunit 2; May play a role in vesicular transport from endoplasmic reticulum to Golgi. Required for the systemic spread of the RNAi response; Belongs to the TRAPP small subunits family. Sedlin subfamily.


ensembl_gene_id: W06B11.1.1
symbol: atat-2
gene_biotype: protein_coding
description:
  Alpha-tubulin N-acetyltransferase 2; Specifically acetylates 'Lys-40' in alpha-tubulin/mec-12 on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act [...]


ensembl_gene_id: W06B3.2c.1
symbol: sma-5
gene_biotype: protein_coding
description:
  Mitogen-activated protein kinase sma-5; Serine/threonine-protein kinase involved in the postembryonic regulation of body size, mainly through control of cell growth. In particular, controls the volume of intestine, muscles and hypodermis. In addition, regulates growth, intestinal granule distribution, lifespan and number of offspring.


ensembl_gene_id: W06B4.3.1
symbol: vps-18
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 18 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the rab-5-to-rab-7 endosome conversion probably implicating sand-1, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion (By similarity). The HOPS complex is proposed to be recruited to  [...]


ensembl_gene_id: W06D12.3.1
symbol: fat-5
gene_biotype: protein_coding
description:
  Delta(9)-fatty-acid desaturase fat-5; Delta(9)-fatty-acid desaturase that acts preferentially on palmitoyl-CoA. Also acts on pentadecanoyl-coA and myristoyl-CoA.


ensembl_gene_id: W06D4.4.1
symbol: prmt-7
gene_biotype: protein_coding
description:
  Protein arginine N-methyltransferase 7; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA).


ensembl_gene_id: W06E11.4.1
symbol: sbds-1
gene_biotype: protein_coding
description:
  Ribosome maturation protein SBDS; Required for the assembly of mature ribosomes and ribosome biogenesis. Together with K10C3.5b/EFL1, triggers the GTP-dependent release of ribosome maturation factors from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation (By similarity).


ensembl_gene_id: W06F12.1a.1
symbol: lit-1
gene_biotype: protein_coding
description:
  Serine/threonine kinase NLK; Has a role in the Wnt signaling pathway controlling the asymmetry of cell divisions during embryogenesis. Operates in the AB and EMS cell lineages influencing cell specification. Required for body wall muscle development, endoderm development, pop-1 asymmetry and T- cell division asymmetry. Lit-1/wrm-1 complex regulates pop-1 localization and is required for pop-1/par-5 interaction. Plays a role in male tail tip morphogenesis.


ensembl_gene_id: W06H3.1.1
symbol: immt-2
gene_biotype: protein_coding
description:
  MICOS complex subunit MIC60-2; Sustains mitochondrial morphology probably through maintaining cristae morphology. May act as a component of the MICOS complex, a large protein complex of the mitochondria (By similarity).


ensembl_gene_id: W06H3.3.1
symbol: ctps-1
gene_biotype: protein_coding
description:
  CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.


ensembl_gene_id: W06H8.1b.2
symbol: rme-1
gene_biotype: protein_coding
description:
  Receptor Mediated Endocytosis; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.


ensembl_gene_id: W06H8.8f.1
symbol: ttn-1
gene_biotype: protein_coding
description:
  Titin homolog; Serine/threonine-protein kinase. Key component in the assembly and functioning of muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase (By similarity).


ensembl_gene_id: W07A12.7.1
symbol: rhy-1
gene_biotype: protein_coding
description:
  Regulator of hypoxia-inducible factor 1; Involved in the response to variation in environmental oxygen levels by inhibiting hif-1-mediated gene transcription in a vhl-1- independent manner. Plays a role in susceptibility to killing mediated by P.aeruginosa and by pore-forming toxins produced by B.thuringiensis. Probably by preventing hif-1 transcriptional activity, regulates behavioral responses, such as locomotion speed following acute reoxygenation. Plays a role in normal egg-laying probably by regulating spermatogenesis and in body morphogenesis.


ensembl_gene_id: W07E11.2.1
symbol: flp-3
gene_biotype: protein_coding
description:
  FMRFamide-like neuropeptides 3; FMRFamides and FMRFamide-like peptides are neuropeptides. SAEPFGTMRF-amide inhibits the activity of dissected pharyngeal myogenic muscle system; Belongs to the FARP (FMRFamide related peptide) family.


ensembl_gene_id: W07E6.1a.1
symbol: nol-2
gene_biotype: protein_coding
description:
  SAM_MT_RSMB_NOP domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.


ensembl_gene_id: W08D2.4a.1
symbol: fat-3
gene_biotype: protein_coding
description:
  Delta(6)-fatty-acid desaturase fat-3; Delta(6) fatty acid desaturase that acts on a range of substrates. Catalyzes the desaturation of linoleic acid (Delta(9,12)- 18:2, or C18:2(n-6)) to gamma-linolenic acid (Delta(6,9,12)-18:3, or C18:3(n-6)). Plays a role in synaptic vesicle recycling by regulating synaptojanin unc-26 localization at synapses.


ensembl_gene_id: W08D2.5a.1
symbol: catp-6
gene_biotype: protein_coding
description:
  Probable cation-transporting ATPase W08D2.5; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.


ensembl_gene_id: W08E3.1.1
symbol: snr-2
gene_biotype: protein_coding
description:
  Probable small nuclear ribonucleoprotein-associated protein B; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. May have a functional role in the pre-mRNA splicing or in snRNP structure (By similarity); Belongs to the snRNP SmB/SmN family.


ensembl_gene_id: W08E3.3a.1
symbol: ola-1
gene_biotype: protein_coding
description:
  Obg-like ATPase 1; Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP; Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.


ensembl_gene_id: W08F4.8b.1
symbol: cdc-37
gene_biotype: protein_coding
description:
  Probable Hsp90 co-chaperone cdc37; Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity (By similarity). Inhibits daf-21/Hsp90 ATPase activity ; Belongs to the CDC37 family.


ensembl_gene_id: W08G11.4.1
symbol: pptr-1
gene_biotype: protein_coding
description:
  Serine/threonine-protein phosphatase 2A regulatory subunit pptr-1; Probable regulatory subunit of serine/threonine-protein phosphatase let-92 which negatively regulates the insulin receptor signaling cascade composed of daf-2, age-1, akt-1, akt-2 and sgk-1 by promoting the dephosphorylation of akt-1 on 'Thr-350'. Negatively regulates several functions controlled by the insulin pathway including dauer formation, lifespan, fat storage and stress resistance. Plays a role in the asymmetric segregation of the P granule components during embryonic cell divisions but does not play an essentia [...]


ensembl_gene_id: W09B12.1.2
symbol: ace-1
gene_biotype: protein_coding
description:
  Acetylcholinesterase 1; Rapidly hydrolyzes choline released into the synapse. It can hydrolyze butyrylthiocholine.


ensembl_gene_id: W09C2.1a.1
symbol: elt-1
gene_biotype: protein_coding
description:
  Transcription factor elt-1; Transcriptional activator that binds to the consensus sequence 5'-[AT]GATA[AG]-3' and variations thereof. During embryonic development, required for specification of cell fate of major hypodermal (epidermal) cells at the blastomere stage. The requirement is true for all four lineages derived from ABarp, ABpra and C blastomeres. Required for seam cell maintenance in late embryogenesis, for proper formation of dauer larvae and locomotion. Regulates expression of bro-1, a regulator of seam cell proliferation, via a GATA-like binding motif. Probably represses ex [...]


ensembl_gene_id: W09C3.4.1
symbol: W09C3.4
gene_biotype: protein_coding
description:
  Probable DNA-directed RNA polymerase III subunit RPC6; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs; Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.


ensembl_gene_id: W09C3.6.1
symbol: gsp-3
gene_biotype: protein_coding
description:
  Serine/threonine-protein phosphatase PP1-gamma; Probable phosphatase which plays a redundant role with gsp-4 in spermatogenesis by regulating sister chromatid segregation during meiosis. In addition, involved in sperm motility by controlling the dynamic disassembly of major sperm proteins (MSP) in the spermatozoan pseudopodium.


ensembl_gene_id: W09C5.5.1
symbol: dkf-1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase dkf-1; Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, independently of PKC. Role in the regulation of growth and neuromuscular control of movement. Involved in immune response to S.aureus bacterium by activating transcription factor hlh-30 downstream of phospholipase plc-1. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.


ensembl_gene_id: W09H1.5.1
symbol: mecr-1
gene_biotype: protein_coding
description:
  Enoyl-[acyl-carrier-protein] reductase, mitochondrial; Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.


ensembl_gene_id: W10C6.1.1
symbol: mat-2
gene_biotype: protein_coding
description:
  Anaphase-promoting complex subunit 1; Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins. Developmental role in early embryogenesis and the metaphase to anaphase transition in oocyte and spermatocyte meiosis and mitosis in germ cells. Required for embryonic anterior-posterior axis formation. Plays a role in regulating the abundance of glr-1 receptors  [...]


ensembl_gene_id: W10C8.2.1
symbol: pop-1
gene_biotype: protein_coding
description:
  Protein pop-1; Part of the Wnt signaling pathway essential for the specification of the mesodermal cell fate in early embryos. Required for asymmetrical division of somatic gonadal precursor descendants which initiate axis formation required to control organ shape. Represses expression of target genes via its interaction with hda-1 histone deacetylase. Required for specification of the M lineage-derived coelomocyte and sex myoblast fate. Regulates coelomocyte fate by positively regulating proliferation and ceh-34 and possibly eya-1 expression in M.dlpa and M.drpa precursors.


ensembl_gene_id: W10D5.2.2
symbol: nduf-7
gene_biotype: protein_coding
description:
  Probable NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).


ensembl_gene_id: W10D5.3c.3
symbol: gei-17
gene_biotype: protein_coding
description:
  E3 SUMO-protein ligase gei-17; Functions as an E3-type smo-1 ligase. Mediates smo-1 conjugation to air-2 in vitro and is required for proper chromosome alignment. In the early embryo, specifically suppresses checkpoint activation in response to DNA damage, maybe by promoting mus-101 sumoylation. In embryos, plays a role in determining telomere localization in the nucleus.


ensembl_gene_id: W10D9.5a.1
symbol: tomm-22
gene_biotype: protein_coding
description:
  Mitochondrial import receptor subunit TOM22 homolog; Central receptor component of the translocase of the outer membrane of mitochondria (TOM complex) responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins (By similarity). Together with the peripheral receptor tomm-20 functions as the transit peptide receptor and facilitates the movement of preproteins into the translocation pore.


ensembl_gene_id: W10G6.2b.1
symbol: sgk-1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase sgk-1; Acts downstream of PI3 kinase age-1 and kinase pdk-1 in the daf-2/insulin receptor-like transduction pathway. Essential role in regulating development, stress response, and longevity. Phosphorylates Forkhead- related daf-16 and the longevity-promoting skn-1 transcription factors, which inhibits their entry into the nucleus and antagonizes their function. Acts downstream of rict-1 to regulate fat storage, size, and development. Downstream of age-1 and together with akt-1/2, promotes cell survival during embryonic development. Does not appear to pla [...]


ensembl_gene_id: W10G6.3.1
symbol: mua-6
gene_biotype: protein_coding
description:
  Intermediate filament protein ifa-2; Cytoplasmic intermediate filaments provide mechanical strength to cells. Essential protein, involved in attachment structures in epidermal cells that connect muscles to the external cuticle. Probably acts by forming hypodermal hemidesmosome complexes that help mediate muscle-cuticle force transduction. Although expressed during embryogenesis, it is not required for embryonic development of muscle- cuticle linkages nor for the localization of other proteins to the hemidesmosomes in embryos.


ensembl_gene_id: Y102A5A.1.1
symbol: cand-1
gene_biotype: protein_coding
description:
  Cullin-associated NEDD8-dissociated protein 1; Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate- recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor (Probable).


ensembl_gene_id: Y102E9.1b.1
symbol: odr-4
gene_biotype: protein_coding
description:
  Odorant response abnormal protein 4; Required, with oct-8, for the localization of a subset of 7 transmembrane domain odorant receptors, including odr-10, to the cilia of olfactory neurons AWA and AWC. Regulates chemotaxis responses to benzaldehyde, diacetyl and 2,4,5- trimethylthiazole in AWA and AWC neurons. Plays a role in nociceptive neurons to mediate avoidance of high oxygen.


ensembl_gene_id: Y102E9.2b.1
symbol: wdr-4
gene_biotype: protein_coding
description:
  tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit; Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit. Belongs to the WD repeat TRM82 family.


ensembl_gene_id: Y104H12A.1a.1
symbol: nhr-41
gene_biotype: protein_coding
description:
  Nuclear hormone receptor family member nhr-41; Orphan nuclear receptor that may have a role in dauer formation; Belongs to the nuclear hormone receptor family.


ensembl_gene_id: Y104H12D.1a.1
symbol: mdt-20
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 20; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).


ensembl_gene_id: Y105C5A.23.1
symbol: daf-38
gene_biotype: protein_coding
description:
  G-protein coupled receptor daf-38; G-protein coupled receptor (GPCR) that forms a heterodimer with daf-37 to control dauer formation and behavior. Required for the response to dauer inducing pheromones such as the ascarosides ascr#2, ascr#3 and ascr#5.


ensembl_gene_id: Y105C5B.21e.1
symbol: jac-1
gene_biotype: protein_coding
description:
  Juxtamembrane domain-associated catenin; May act as a positive modulator of hmr-1 function during epidermal morphogenesis. Required for proper localization of other junctional components, such as pac-1 ; Belongs to the beta-catenin family.


ensembl_gene_id: Y105C5B.2a.1
symbol: gcy-25
gene_biotype: protein_coding
description:
  Receptor-type guanylate cyclase gcy-25; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity); Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.


ensembl_gene_id: Y105C5B.9.1
symbol: Y105C5B.9
gene_biotype: protein_coding
description:
  Phytanoyl-CoA dioxygenase domain-containing protein 1 homolog; Has alpha-ketoglutarate-dependent dioxygenase activity. Does not show detectable activity towards fatty acid CoA thioesters. Is not expected to be active with phytanoyl CoA (By similarity). Belongs to the PhyH family. PHYHD1 subfamily.


ensembl_gene_id: Y105E8A.22.1
symbol: exc-4
gene_biotype: protein_coding
description:
  Chloride intracellular channel exc-4; May insert into membranes and form chloride ion channels. Involved in the formation of the excretory canal. Required to prevent cystic lumenal expansions in the excretory cell. Not required for formation of the initial tube, but is required for regulating the size of the tube lumen as it grows.


ensembl_gene_id: Y105E8A.23b.1
symbol: rpom-1
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the phage and mitochondrial RNA polymerase family.


ensembl_gene_id: Y105E8A.5.1
symbol: bbs-1
gene_biotype: protein_coding
description:
  Bardet-Biedl syndrome 1 protein homolog; Component of the BBSome complex (By similarity). The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia (By similarity). The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function (By similarity). Required for proper BBSome complex assembly and its ciliary localization. Required for cilia biogenesis and both the assembly and movement of intraflagellar transport proteins along the ciliary axoneme.


ensembl_gene_id: Y105E8A.6.1
symbol: unc-95
gene_biotype: protein_coding
description:
  LIM domain-containing protein unc-95; Required for the assembly and integrity of muscle dense bodies, which establish the adhesion sites of the muscle cells to the extracellular matrix. Decreased localization of unc-95 to dense bodies and their subsequent dissociation plays an important role in ecdysis during molting. Involved in the organization of the muscle sarcomeric structure and thereby required for locomotion.


ensembl_gene_id: Y105E8B.1d.1
symbol: lev-11
gene_biotype: protein_coding
description:
  Tropomyosin isoforms a/b/d/f; Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction. Involved in muscle actin filament organization and muscle arm extension and morphology. Protects actin filaments from depolymerization by unc-60 in vitro. Also has a role in male mating behavior by regulating the copulatory spicules. Binds to F-actin.


ensembl_gene_id: Y105E8B.3.1
symbol: riok-2
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase RIO2; Required for larval development. Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.


ensembl_gene_id: Y105E8B.4.1
symbol: bath-40
gene_biotype: protein_coding
description:
  BTB and MATH domain-containing protein 40; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.


ensembl_gene_id: Y105E8B.8c.2
symbol: ero-1
gene_biotype: protein_coding
description:
  Endoplasmic reticulum oxidoreductin-1; Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes pdi-1, the enzyme catalyzing protein disulfide formation, in order to allow pdi-1 to sustain additional rounds of disulfide formation. Following pdi reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell (By similarity).


ensembl_gene_id: Y106G6A.5a.1
symbol: dsbn-1
gene_biotype: protein_coding
description:
  Dysbindin protein homolog; Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in gut granule biogenesis. Belongs to the dysbindin family.


ensembl_gene_id: Y106G6E.4.1
symbol: Y106G6E.4
gene_biotype: protein_coding
description:
  Probable 5-formyltetrahydrofolate cyclo-ligase; Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids. Catalyzes the irreversible conversion of 5- formyltetrahydrofolate (5-CHO-H(4)PteGlu) to yield 5,10- methenyltetrahydrofolate (By similarity).


ensembl_gene_id: Y106G6E.5b.1
symbol: ced-12
gene_biotype: protein_coding
description:
  Cell death abnormality protein 12; Involved in programmed apoptosis and necrosis. Required for the cell corpse engulfment process. Has roles in the formation of actin halos and distal tip cell migration. Negatively regulates the unc-6/Netrin receptor unc-5 to control distal tip cell migration along the anterior-posterior axis of the body. Plays no role in amphid axon outgrowth.


ensembl_gene_id: Y106G6E.6.1
symbol: csnk-1
gene_biotype: protein_coding
description:
  Casein kinase I gamma; Involved in the asymmetric cell division of the embryo downstream of par-2 and par-3 by regulating the asymmetric cortical distribution of pkk-1, a phosphatidylinositol 4,5-bisphosphate- producing enzyme, which in turn regulates the asymmetrical distribution of grp-1, grp-2 and lin-5.


ensembl_gene_id: Y106G6H.15.2
symbol: ska-1
gene_biotype: protein_coding
description:
  Spindle and kinetochore-associated protein 1; Component of the ska-1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint (By similarity). The ska-1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies (By similarity). The complex facilitates the processive movement of micr [...]


ensembl_gene_id: Y106G6H.7.1
symbol: sec-8
gene_biotype: protein_coding
description:
  Exocyst complex component 4; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.


ensembl_gene_id: Y108G3AL.1a.3
symbol: cul-3
gene_biotype: protein_coding
description:
  Cullin-3; Probable core component of multiple cullin-RING-based BCB (BTB-CUL3-BTB) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Probably acts as a scaffold protein which may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Required to target mei-3/katanin for degradation at the meiosis to mitosis transition via its neddylation and deneddylation. Functions in ubiquitin-mediated degradation of CKIs to target cki-1 for degradation. Regulates microtubule st [...]


ensembl_gene_id: Y110A2AL.12a.1
symbol: hpo-20
gene_biotype: protein_coding
description:
  Phosphatidylinositol-glycan biosynthesis class W protein; Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.


ensembl_gene_id: Y110A2AL.14.1
symbol: sqv-2
gene_biotype: protein_coding
description:
  Beta-1,3-galactosyltransferase sqv-2; Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-linked galactose residue. Required for vulval morphogenesis and zygotic cytokinesis, suggesting that glycosaminoglycans play a central role in vulval morphogenesis.


ensembl_gene_id: Y110A2AL.8c.2
symbol: ptc-3
gene_biotype: protein_coding
description:
  Protein patched homolog 3; Regulates osmosis during embryonic development. Required for larval development and in particular is involved in larval molting. Belongs to the patched family.


ensembl_gene_id: Y110A7A.11.1
symbol: use-1
gene_biotype: protein_coding
description:
  Vesicle transport protein USE1; SNARE that may be involved in targeting and fusion of Golgi- derived retrograde transport vesicles with the ER; Belongs to the USE1 family.


ensembl_gene_id: Y110A7A.12.1
symbol: spe-5
gene_biotype: protein_coding
description:
  Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family.


ensembl_gene_id: Y110A7A.14.2
symbol: pas-3
gene_biotype: protein_coding
description:
  Proteasome subunit alpha type-4; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity); Belongs to the peptidase T1A family.


ensembl_gene_id: Y110A7A.16.1
symbol: elpc-1
gene_biotype: protein_coding
description:
  Elongator complex protein 1; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. Belongs to the ELP1/IKA1 family.


ensembl_gene_id: Y110A7A.17a.1
symbol: mat-1
gene_biotype: protein_coding
description:
  Cell division cycle protein 27 homolog; Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (By similarity). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins (By similarity). Developmental role in early embryogenesis and the metaphase to anaphase transition in oocyte and spermatocyte meiosis and mitosis in germ cells. Required for embryonic anterior-posterior axis formation. Plays a role in regulating [...]


ensembl_gene_id: Y110A7A.20.1
symbol: ift-20
gene_biotype: protein_coding
description:
  Intraflagellar transport protein 20 homolog; Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. Required for ciliary entrance and transport of specific ciliary cargo proteins such as che-3 which are related to motility.


ensembl_gene_id: Y110A7A.3.1
symbol: unc-63
gene_biotype: protein_coding
description:
  Acetylcholine receptor subunit alpha-type unc-63; Alpha subunit of nicotinic acetylcholine receptor (nAChR). Probably acts in cholinergic motoneurons to regulate presynaptic neurotransmitter release, thereby ensuring normal level of excitation of cholinergic motoneurons during locomotion. Involved in nAChR sensitivity to nicotine and levamisole.


ensembl_gene_id: Y110A7A.5.1
symbol: mtm-1
gene_biotype: protein_coding
description:
  Myotubularin-related protein 1; Dephosphorylates phosphatidylinositol 3-phosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Negatively regulates accumulation of PI3P on intracellular vesicles. Negatively regulates phagocytosis of apoptotic cells probably by limiting the recruitment and/or the activation of ced-5, ced-2 and ced-12 complex. In addition, may positively regulate phagosome maturation by promoting recycling of apoptotic receptor ced-1 back to the plasma membrane. Essential for embryonic and larval development. May promote migration of distal tip cells ; B [...]


ensembl_gene_id: Y111B2A.13.1
symbol: gtf-2A2
gene_biotype: protein_coding
description:
  Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity.


ensembl_gene_id: Y111B2A.15.1
symbol: tpst-1
gene_biotype: protein_coding
description:
  Protein-tyrosine sulfotransferase A; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.


ensembl_gene_id: Y111B2A.22a.1
symbol: ssl-1
gene_biotype: protein_coding
description:
  Helicase ssl-1; Probable catalytic component of a chromatin-remodeling complex which mediates the ATP-dependent exchange of histone H2A variant H2AV/htz-1 for H2A, leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in foregut development, and may be involved in vulval development. Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.


ensembl_gene_id: Y113G7A.3.1
symbol: sec-23
gene_biotype: protein_coding
description:
  Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily.


ensembl_gene_id: Y113G7A.8b.1
symbol: fre-1
gene_biotype: protein_coding
description:
  NADPH-dependent diflavin oxidoreductase 1; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe-S cluster of the anamorsin/DRE2 homolog. Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family. In the N-terminal section; belongs to the flavodoxin family.


ensembl_gene_id: Y113G7A.9a.1
symbol: dcs-1
gene_biotype: protein_coding
description:
  m7GpppX diphosphatase; Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs of the 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) and tri-methyl guanosine nucleoside triphosphate (m3(2,2,7)GpppG) with up to 2 nucleotide substrates (small capped oligoribonucleotides) and specifically releases 5'-phosphorylated RNA fragments and 7- methylguanosine monophosphate (m7GMP). Does not hydrolyze unmethylated cap analog (GpppG) and shows no decap [...]


ensembl_gene_id: Y113G7B.17.1
symbol: prmt-1
gene_biotype: protein_coding
description:
  Protein arginine N-methyltransferase 1; Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in target proteins. Catalyzes the formation of monomethylarginine and asymmetric dimethylarginine on histones H2A and H4, a specific tag for epigenetic transcriptional activation. Catalyzes asymmetric arginine dimethylation of mitochondrial proteins necessary for mitochondrial oxidative phosphorylation activity and thus aerobic respiration and ATP synthesis, and the mitochondrial stress response. Methylates arginine r [...]


ensembl_gene_id: Y113G7B.18b.1
symbol: mdt-17
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 17; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).


ensembl_gene_id: Y113G7B.24a.1
symbol: sld-5
gene_biotype: protein_coding
description:
  DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family.


ensembl_gene_id: Y116A8A.9b.2
symbol: map-2
gene_biotype: protein_coding
description:
  Methionine aminopeptidase 2; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Required for germ cell proliferation and/or differentiation.


ensembl_gene_id: Y116A8C.28d.1
symbol: bca-2
gene_biotype: protein_coding
description:
  Carbonic anhydrase; Reversible hydration of carbon dioxide. Belongs to the beta-class carbonic anhydrase family.


ensembl_gene_id: Y116A8C.34a.1
symbol: cyn-13
gene_biotype: protein_coding
description:
  Peptidyl-prolyl cis-trans isomerase E; Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins.


ensembl_gene_id: Y116A8C.42.1
symbol: snr-1
gene_biotype: protein_coding
description:
  Small nuclear ribonucleoprotein Sm D3; Required for pre-mRNA splicing. Required for snRNP biogenesis (By similarity); Belongs to the snRNP core protein family.


ensembl_gene_id: Y116F11B.12a.1
symbol: gly-4
gene_biotype: protein_coding
description:
  Polypeptide N-acetylgalactosaminyltransferase 4; Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor.


ensembl_gene_id: Y119C1B.8a.1
symbol: bet-1
gene_biotype: protein_coding
description:
  Bromodomain-containing protein bet-1; Required for the establishment and maintenance of stable cell fate in several lineages including V5.pa, T, Z1/Z4 and QR lineages probably by repressing the expression of cell fate determinants. Required to maintain non-distal tip cell (DTC) fate of somatic gonadal cells through the htz-1-mediated repression of transcription factor ceh-22. Regulates the subnuclear localization of histone variant htz-1 in somatic gonadal cells. Plays a role in the attenuation of the let-60/ras pathway, probably by preventing expression of activators of the pathway. I [...]


ensembl_gene_id: Y119D3B.15.1
symbol: dss-1
gene_biotype: protein_coding
description:
  Probable 26S proteasome complex subunit dss-1; Subunit of the 26S proteasome which plays a role in ubiquitin-dependent proteolysis. Has an essential role in oogenesis and larval growth. Required for intestinal function and default lifespan.


ensembl_gene_id: Y11D7A.4.1
symbol: rab-28
gene_biotype: protein_coding
description:
  Ras-related protein Rab-28; GTPase. Intraflagellar transport (IFT) cargo that undergoes bidirectional IFT along the ciliary axoneme when in active GTP-bound state in amphid and phasmid ciliated sensory neurons. Targeting and function as IFT cargo may depend on the BBSome, an IFT cargo adapter. Does not undergo IFT when in inactive GDP-bound state. May in turn play a role in cilium structure and/or function in ciliated sensory neurons. Belongs to the small GTPase superfamily. Rab family.


ensembl_gene_id: Y15E3A.1a.2
symbol: nhr-91
gene_biotype: protein_coding
description:
  Nuclear hormone receptor family member nhr-91; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family.


ensembl_gene_id: Y16B4A.1.1
symbol: unc-3
gene_biotype: protein_coding
description:
  Transcription factor unc-3; May play a role in the expression of proteins essential for axonal pathfinding and/or neuronal differentiation in both sensory and motor neurons. Cooperates with jmjd-3.1 and wdr-5.1 to ensure robust transdifferentiation of the Y rectal cell to the PDA motor neuron during larval development.


ensembl_gene_id: Y17G7B.10b.3
symbol: Y17G7B.10
gene_biotype: protein_coding
description:
  NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.


ensembl_gene_id: Y17G7B.13.1
symbol: ippk-1
gene_biotype: protein_coding
description:
  Inositol-pentakisphosphate 2-kinase; Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).


ensembl_gene_id: Y17G7B.15a.1
symbol: cnt-1
gene_biotype: protein_coding
description:
  Arf-GAP with ANK repeat and PH domain-containing protein cnt-1; GTPase-activating protein for the ADP ribosylation factor family (Probable). Regulates endosome recycling downstream of rab-10 and upstream of arf-6.


ensembl_gene_id: Y17G7B.18b.1
symbol: Y17G7B.18
gene_biotype: protein_coding
description:
  Probable RNA methyltransferase Y17G7B.18; Probable RNA methyltransferase; Belongs to the methyltransferase superfamily.


ensembl_gene_id: Y17G7B.2d.1
symbol: ash-2
gene_biotype: protein_coding
description:
  Set1/Ash2 histone methyltransferase complex subunit ash-2; Component of the set-2/ash-2 histone methyltransferase (HMT) complex (Probable). Required for the di- and trimethylation at 'Lys-4' of histone H3, a mark associated with epigenetic transcriptional activation. Implicated in the epigenetic inheritance of lifespan over several generations. Functions as transcriptional regulator. Acts in the germline to limit the longevity of the soma, probably by regulating a lipid metabolism pathway that signals from the germline to the intestine, thereby preventing accumulation of mono-unsaturat [...]


ensembl_gene_id: Y17G7B.4.1
symbol: dhps-1
gene_biotype: protein_coding
description:
  Deoxyhypusine synthase; Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a critical lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. This is the first step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function.


ensembl_gene_id: Y17G7B.7.1
symbol: tpi-1
gene_biotype: protein_coding
description:
  Triosephosphate isomerase; Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis.


ensembl_gene_id: Y18D10A.13.2
symbol: pad-1
gene_biotype: protein_coding
description:
  Protein pad-1; May be involved in protein traffic between late Golgi and early endosomes (By similarity). Essential for cell patterning during gastrulation.


ensembl_gene_id: Y18D10A.20.1
symbol: pfn-1
gene_biotype: protein_coding
description:
  Profilin-1; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Also binds to poly(L-proline) and phosphatidylinositol 4,5-bisphosphate micelles.


ensembl_gene_id: Y18D10A.3.1
symbol: Y18D10A.3
gene_biotype: protein_coding
description:
  NAD(P)H-hydrate epimerase; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX; Belongs to the NnrE/AIBP family.


ensembl_gene_id: Y18D10A.5.1
symbol: gsk-3
gene_biotype: protein_coding
description:
  Glycogen synthase kinase-3; Phosphorylates oma-1, a regulator of the oocyte-to-embryo transition, enabling its degradation. Phosphorylates skn-1, preventing it from accumulating in nuclei and thus inhibiting phase II gene expression in the oxidative stress defense. Involved in mesendoderm specification and mitotic spindle orientation in EMS blastomeres. Thought to be a branch point in these processes as proteins downstream are not required. Negatively regulates Wnt signaling in vulval precursor cells and acts as a Wnt-independent repressor of med-1 and med-2 in the C lineage inhibiting [...]


ensembl_gene_id: Y18D10A.8.1
symbol: mxt-1
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 4E-binding protein Mextli homolog; Plays a role in promoting translation.


ensembl_gene_id: Y18D10A.9.1
symbol: Y18D10A.9
gene_biotype: protein_coding
description:
  Probable cytosolic iron-sulfur protein assembly protein CIAO1 homolog; Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins; Belongs to the WD repeat CIA1 family.


ensembl_gene_id: Y18H1A.6a.1
symbol: pif-1
gene_biotype: protein_coding
description:
  ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.


ensembl_gene_id: Y20F4.2.2
symbol: crtc-1
gene_biotype: protein_coding
description:
  CREB-regulated transcription coactivator 1 homolog; Transcriptional coactivator for crh-1, the homolog of vertebrate transcription factor CREB1. Regulates the transcription of metabolic genes and may have a role in mitochondrial dynamics and metabolism. Through crh-1, counteracts the pro-lifespan-extension signals of AMPK both cell autonomously and, when expressed in neurons, at a systemic level, possibly using the catecholamine analog, octopamine, as a messenger ; Belongs to the TORC family.


ensembl_gene_id: Y22D7AL.5a.1
symbol: hsp-60
gene_biotype: protein_coding
description:
  Chaperonin homolog Hsp-60, mitochondrial; Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (By similarity).


ensembl_gene_id: Y22D7AL.8b.1
symbol: sms-3
gene_biotype: protein_coding
description:
  Putative phosphatidylcholine:ceramide cholinephosphotransferase 3; Bidirectional lipid cholinephosphotransferase capable of converting phosphatidylcholine (PC) and ceramide to sphingomyelin (SM) and diacylglycerol (DAG) and vice versa. Direction is dependent on the relative concentrations of DAG and ceramide as phosphocholine acceptors. Directly and specifically recognizes the choline head group on the substrate. Also requires two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Does not function strictly as a SM synthase (By similarity).


ensembl_gene_id: Y22F5A.4.2
symbol: lys-1
gene_biotype: protein_coding
description:
  Lysozyme-like protein 1; Involved in resistance to Gram-negative bacterium S.marcescens and to bacterium Gram-positive S.aureus infection.


ensembl_gene_id: Y22F5A.5.1
symbol: lys-2
gene_biotype: protein_coding
description:
  Lysozyme-like protein 2; Involved in resistance to Gram-positive bacteria P.aeruginosa or B.thuringiensis infection; Belongs to the glycosyl hydrolase 25 family.


ensembl_gene_id: Y22F5A.6.1
symbol: lys-3
gene_biotype: protein_coding
description:
  Lysozyme-like protein 3; Plays a role in the stress response to heavy metals such as copper, probably in a kgb-1-dependent manner.


ensembl_gene_id: Y24D9A.8a.2
symbol: tald-1
gene_biotype: protein_coding
description:
  Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.


ensembl_gene_id: Y25C1A.5.1
symbol: copb-1
gene_biotype: protein_coding
description:
  Coatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.


ensembl_gene_id: Y2H9A.1.1
symbol: mes-4
gene_biotype: protein_coding
description:
  Histone-lysine N-methyltransferase mes-4; Histone methyltransferase. Dimethylates 'Lys-36' of histone H3, a specific tag for epigenetic transcriptional activation. Plays a central role in early development and is responsible for all H3 'Lys- 36' dimethylation until about the 40-cell stage. Indirectly involved in the global inactivation of the X chromosomes in germline cells, possibly by excluding the mes-2-mes-3-mes-6 repressive Polycomb complex from the autosomes. Not related to transcription elongation. Required for small-RNA-induced H3K27 trimethylation. May suppress sensitivity to  [...]


ensembl_gene_id: Y34B4A.3.1
symbol: hst-6
gene_biotype: protein_coding
description:
  Heparan-sulfate 6-O-sulfotransferase; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.


ensembl_gene_id: Y37A1B.2b.1
symbol: lst-4
gene_biotype: protein_coding
description:
  Sorting nexin lst-4; Involved in the signaling of vulval development by acting as a negative regulator of epidermal growth factor receptor (EGFR) signaling. Aids in phagosomal membrane tubule formation which is required for phagosomal fusion with endosomes and lysosomes. Also recruits rab-7 to phagosomes by an interaction with dyn-1. These are events leading to phagosome maturation which is a step in apoptotic cell corpse clearance. Binds phosphatidylinositol-3,4,5-trisphosphate. Belongs to the sorting nexin family.


ensembl_gene_id: Y37D8A.1.1
symbol: arx-5
gene_biotype: protein_coding
description:
  Probable actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.


ensembl_gene_id: Y37D8A.10.2
symbol: hpo-21
gene_biotype: protein_coding
description:
  Probable signal peptidase complex subunit 2; Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.


ensembl_gene_id: Y37D8A.13.1
symbol: unc-71
gene_biotype: protein_coding
description:
  Disintegrin and metalloproteinase domain-containing protein unc-71; Involved in the migration of sex myoblasts (progenitors of egg-laying muscles), Q neuroblasts and BDU interneurons during development. Involved in axon branching and guidance of neurons including GABAergic type D motor neurons. Promotes sex myoblast migration and positioning independently of gonad attraction cues. May act downstream of mig-13 in order to promote the guidance, migration and positioning of Q neuroblasts and their descendants along the anteroposterior body axis. Required for coordinated movements.


ensembl_gene_id: Y37D8A.14.1
symbol: cox-5A
gene_biotype: protein_coding
description:
  Cytochrome c oxidase subunit 5A, mitochondrial; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane [...]


ensembl_gene_id: Y37D8A.15.1
symbol: flp-14
gene_biotype: protein_coding
description:
  FMRFamide-like neuropeptides 14; FMRFamides and FMRFamide-like peptides are neuropeptides. KHEYLRF-amide has an excitatory effect on dissected pharyngeal myogenic muscle system. Functions in RID peptidergic neurons to promote forward locomotory behavior.


ensembl_gene_id: Y37D8A.18.1
symbol: mrps-10
gene_biotype: protein_coding
description:
  Probable 28S ribosomal protein S10, mitochondrial; Ribosomal protein required for normal mitochondrial function and normal larval development. Thought to have a role in insulin/IGF signaling.


ensembl_gene_id: Y37D8A.2.1
symbol: Y37D8A.2
gene_biotype: protein_coding
description:
  Putative phospholipase B-like 1; Putative phospholipase; Belongs to the phospholipase B-like family.


ensembl_gene_id: Y37D8A.22.1
symbol: epg-3
gene_biotype: protein_coding
description:
  Ectopic P granules protein 3; Involved in autophagy. Thought to act in autophagasome and omegasome formation.


ensembl_gene_id: Y37E11AL.7a.1
symbol: map-1
gene_biotype: protein_coding
description:
  Methionine aminopeptidase; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val).


ensembl_gene_id: Y37E11AR.2.1
symbol: siah-1
gene_biotype: protein_coding
description:
  E3 ubiquitin-protein ligase siah-1; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It probably triggers the ubiquitin-mediated degradation of different substrates.


ensembl_gene_id: Y37E11B.4.1
symbol: taf-2
gene_biotype: protein_coding
description:
  Transcription initiation factor TFIID subunit 2; Component of general transcription factor TFIID which establishes the initiation site for mRNA transcription (By similarity). May regulate RNA polymerase II activity and thereby may control transcription initiation by RNA polymerase II. Belongs to the TAF2 family.


ensembl_gene_id: Y37E11C.1a.1
symbol: unc-33
gene_biotype: protein_coding
description:
  Protein unc-33; During neurogenesis, plays an essential role in axonal guidance and outgrowth by regulating the polarization of both microtubule and actin cytoskeletons. Establishes the asymmetry of axonal and dendrite microtubules and the polarized sorting of neuronal proteins. This is achieved in part by regulating the localization of kinesin-like protein unc-104. In neurons without a distal microtubule- organizing center (MTOC), also controls the organization of microtubules in dendrites. During the dorso-ventral axonal guidance and outgrowth of VD neurons, required downstream of Ra [...]


ensembl_gene_id: Y37E3.3.1
symbol: rpb-10
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerases I, II, and III subunit RPABC5; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RBP10 is part of the cor [...]


ensembl_gene_id: Y37E3.4.1
symbol: moag-4
gene_biotype: protein_coding
description:
  Modifier of protein aggregation 4; Positive regulator of protein aggregation and age-related proteotoxicity. Induces conformational changes in aggregation-prone proteins, driving them into compact formations preceding the formation of aggregates.


ensembl_gene_id: Y37E3.5a.1
symbol: arl-13
gene_biotype: protein_coding
description:
  ADP-ribosylation factor-like protein 13B; Cilium-specific protein required to control the microtubule- based, ciliary axoneme structure. Required for normal sensory cilium function. May act by maintaining the association between IFT subcomplexes A and B; Belongs to the small GTPase superfamily. Arf family.


ensembl_gene_id: Y37E3.7.3
symbol: rla-1
gene_biotype: protein_coding
description:
  60S acidic ribosomal protein P1; Plays an important role in the elongation step of protein synthesis; Belongs to the eukaryotic ribosomal protein P1/P2 family.


ensembl_gene_id: Y37E3.8a.1
symbol: Y37E3.8
gene_biotype: protein_coding
description:
  Ribosomal_L18e/L15P domain-containing protein; Belongs to the universal ribosomal protein uL15 family.


ensembl_gene_id: Y37E3.9.1
symbol: phb-1
gene_biotype: protein_coding
description:
  Mitochondrial prohibitin complex protein 1; PHB proteins are essential during embryonic development and are required for somatic and germline differentiation in the larval gonad. A deficiency in PHB proteins results in altered mitochondrial biogenesis in body wall muscle cells.


ensembl_gene_id: Y37H9A.6.1
symbol: ndx-4
gene_biotype: protein_coding
description:
  Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]; Asymmetrically hydrolyzes Ap4A to yield AMP and ATP.


ensembl_gene_id: Y38A10A.5.2
symbol: crt-1
gene_biotype: protein_coding
description:
  Calreticulin; Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle (By similarity). This lectin may interact transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (By similarity). Probably by controlling the folding of extracellular matrix protein unc-52/Perlecan, may play a role in the formation of fibrous organelles, a hemidesmosome-like structure attaching muscles to the epidermis. Protects dopaminergic neurons against oxidative stress-induced neurodegen [...]


ensembl_gene_id: Y38A8.1.1
symbol: ndx-3
gene_biotype: protein_coding
description:
  Nudix hydrolase 3; Probably mediates the hydrolysis of some nucleoside diphosphate derivatives; Belongs to the Nudix hydrolase family. PCD1 subfamily.


ensembl_gene_id: Y38A8.2.1
symbol: pbs-3
gene_biotype: protein_coding
description:
  Proteasome subunit beta type-3; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).


ensembl_gene_id: Y38A8.3a.2
symbol: ulp-2
gene_biotype: protein_coding
description:
  Ubiquitin-like protease 2; Protease that catalyzes two essential functions in the smo-1 pathway: processing of full-length smo-1 to their mature forms and deconjugation of smo-1 from targeted proteins (By similarity). May deconjugate smo-1 from the cadherin protein hmr-1 and plays a role in its recruitment to and the maintenance of adherens junctions. Required for epidermal morphogenesis during embryonic development ; Belongs to the peptidase C48 family.


ensembl_gene_id: Y38C1AA.2.1
symbol: csn-3
gene_biotype: protein_coding
description:
  COP9 signalosome complex subunit 3; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. The CSN complex plays an essential role in embryogenesis and oogenesis and is required to regulate microtubule stability in the early embryo. Mediates mei-3/katanin targeting for degradation at the meiosis to mi [...]


ensembl_gene_id: Y38C1AA.4a.1
symbol: tcl-2
gene_biotype: protein_coding
description:
  T-cell defective protein 2; May act synergistically with the Wnt pathways to control T- cell fate specification, gonad development, and P12 cell fate specification. Required for the distribution of pop-1 and tlp-1 proteins.


ensembl_gene_id: Y38C9A.2a.2
symbol: cgp-1
gene_biotype: protein_coding
description:
  GTP-binding protein cgp-1; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. GTPBP1 subfamily.


ensembl_gene_id: Y38F1A.10e.1
symbol: max-2
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase max-2; Serine/threonine-protein kinase, which phosphorylates mlk-1. Involved in the stress response to heavy metals by activating the mlk- 1/mek-1/kgb-1 pathway. In ventral cord commissural motoneurons, required for dorsal axon guidance downstream of unc- 6/netrin repulsion receptor unc-5 and probably of Rho GTPases ced-10 and mig-2. Plays a redundant role with mig-10 in orientating axonal growth of HSN neurons. Plays a redundant role with pak-1 in P neuroblast migration and in distal tip cell (DTC)-mediated guidance of gonad elongation probably downstre [...]


ensembl_gene_id: Y38F1A.5.2
symbol: cyd-1
gene_biotype: protein_coding
description:
  G1/S-specific cyclin-D; In association with cdk-4, regulates the progression through the G1 phase of the cell cycle during postembryonic development. Regulates proliferation of the coelomocyte lineage and intestinal cells during late embryogenesis. In complex with cdk-4, involved in sex determination during gonadogenesis by regulating the asymmetric division of the somatic gonadal precursor cell (SGP).


ensembl_gene_id: Y38F1A.6.1
symbol: hphd-1
gene_biotype: protein_coding
description:
  Hydroxyacid-oxoacid transhydrogenase, mitochondrial; Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). L-3-hydroxybutyrate (L-3-OHB) is also a substrate for HOT when using 2- KG as hydrogen acceptor, resulting in the formation of D-2-HG. Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.


ensembl_gene_id: Y38F2AL.3a.1
symbol: vha-11
gene_biotype: protein_coding
description:
  V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Has roles in embryogenesis and ovulation.


ensembl_gene_id: Y38F2AR.9.1
symbol: Y38F2AR.9
gene_biotype: protein_coding
description:
  Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum.


ensembl_gene_id: Y39A1A.12.1
symbol: orc-1
gene_biotype: protein_coding
description:
  Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.


ensembl_gene_id: Y39A1A.14.1
symbol: Y39A1A.14
gene_biotype: protein_coding
description:
  Ribosomal RNA small subunit methyltransferase nep-1; S-adenosyl-L-methionine-dependent pseudouridine N(1)- methyltransferase that methylates a pseudouridine in 18S rRNA. Involved the biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3- carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA. Has also an essential role in 40S ribosomal subunit biogenesis independent on its methyltransferase activity, facilitating the incorporation of ribosomal protein S19 during the formation of pre- ribosomes; Belongs to the class IV-like SAM-binding methyltransferase superfami [...]


ensembl_gene_id: Y39A1A.15a.1
symbol: cnt-2
gene_biotype: protein_coding
description:
  Arf-GAP with ANK repeat and PH domain-containing protein cnt-2; GTPase-activating protein for the ADP ribosylation factor family (Probable). During neurogenesis, involved in cell autonomous neuroblast asymmetric divisions that generate one precursor cell and one apoptotic cell probably by controlling endocytosis. In oocytes, involved in vitellogenin vit-2 uptake by regulating receptor rme-2 endocytosis; Belongs to the centaurin gamma-like family.


ensembl_gene_id: Y39A1A.1b.1
symbol: epg-6
gene_biotype: protein_coding
description:
  Ectopic P granules protein 6; Component of the epg-6/atg-2 complex, which is involved in the generation of autophagosomes from omegasomes and in the distribution of atg-9 and atg-13 during the autophagy-mediated degradation of protein aggregates. Binds to phosphatidylinositols on preautophagosomes, which are early autophagic structures, to promote autophagosome formation. In particular, binds with high affinity to phosphatidylinositols including phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P), but more weakly to phosphatidylinositol 4- ph [...]


ensembl_gene_id: Y39A1A.21a.1
symbol: Y39A1A.21
gene_biotype: protein_coding
description:
  ATP synthase subunit C lysine N-methyltransferase; Mitochondrial protein-lysine N-methyltransferase that trimethylates ATP synthase subunit C. Trimethylation is required for proper incorporation of the C subunit into the ATP synthase complex and mitochondrial respiration.


ensembl_gene_id: Y39A1A.23a.1
symbol: hpr-9
gene_biotype: protein_coding
description:
  Cell cycle checkpoint protein hpr-9; May be a component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair.


ensembl_gene_id: Y39A1B.3.1
symbol: dpy-28
gene_biotype: protein_coding
description:
  Condensin complex subunit 1; Required for both chromosome condensation and segregation during mitosis and meiosis and X-chromosome dosage compensation depending on its binding partners. Regulatory subunit of the condensin I complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin I complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (By similarity). The condensin I complex func [...]


ensembl_gene_id: Y39A3CR.1a.1
symbol: smi-1
gene_biotype: protein_coding
description:
  Gem-associated protein 2; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs; Belongs to the gemin-2 family.


ensembl_gene_id: Y39A3CR.4.1
symbol: ddp-1
gene_biotype: protein_coding
description:
  Mitochondrial import inner membrane translocase subunit Tim8; Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane (By similarity). Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane (By similarity). Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity). The ddp-1/t [...]


ensembl_gene_id: Y39B6A.14.1
symbol: pro-3
gene_biotype: protein_coding
description:
  Protein SDA1 homolog; Required for 60S pre-ribosomal subunits export to the cytoplasm (Probable). Required for normal somatic gonad development and for regulation of germline development and proliferation.


ensembl_gene_id: Y39B6A.20.2
symbol: asp-1
gene_biotype: protein_coding
description:
  Aspartic protease 1; Aspartic protease, which is part of the necrosis cell death pathway. Promotes B.thuringiensis Cry6Aa stability by preventing its proteolysis by host gut proteases. Required for Cry6Aa-induced necrotic death of intestinal cells. Cry6Aa uptake into the host intestinal cells triggers an increase in intracellular Ca(2+) levels leading to lysosome rupture and to the subsequent release of asp-1 which leads to necrosis ; Belongs to the peptidase A1 family.


ensembl_gene_id: Y39B6A.2a.1
symbol: pph-5
gene_biotype: protein_coding
description:
  Serine/threonine-protein phosphatase 5; Serine/threonine-protein phosphatase. Dephosphorylates cdc-37. Probably by dephosphorylating separase sep-1, may be involved in sep-1-mediated exocytosis of cortical granules during meiotic anaphase and mitotic cytokinesis.


ensembl_gene_id: Y39B6A.33.1
symbol: Y39B6A.33
gene_biotype: protein_coding
description:
  Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis, being required for integration of the 5S RNP into the ribosomal large subunit.


ensembl_gene_id: Y39B6A.34a.1
symbol: Y39B6A.34
gene_biotype: protein_coding
description:
  COA8 family protein Y39B6A.34, mitochondrial; May be required for cytochrome c complex (COX) assembly and function, COX being the terminal component of the mitochondrial respiratory chain; Belongs to the COA8 family.


ensembl_gene_id: Y39B6A.35.1
symbol: tgt-2
gene_biotype: protein_coding
description:
  Queuine tRNA-ribosyltransferase accessory subunit 2; Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine); Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.


ensembl_gene_id: Y39B6A.36.1
symbol: gtf-2F2
gene_biotype: protein_coding
description:
  General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity.


ensembl_gene_id: Y39E4A.2b.1
symbol: ttm-1
gene_biotype: protein_coding
description:
  Zinc transporter ttm-1; Promotes excretion of zinc from intestinal cells into the intestinal lumen in response to increased dietary zinc. Involved in cadmium resistance, possibly by promoting its transport from cells. Involved in resistance to B.thuringiensis pore-forming toxin Cry5B downstream of the sek-1 and pmk-1 MAPK kinase pathway.


ensembl_gene_id: Y39E4A.3b.1
symbol: bckd-1A
gene_biotype: protein_coding
description:
  2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). Required for the production of the monomethyl branched-chain fatty acids (mmBCFAs) isopentadecanoate (C15iso) and isoheptadecanoate (C17iso).


ensembl_gene_id: Y39E4B.12a.1
symbol: gly-5
gene_biotype: protein_coding
description:
  Polypeptide N-acetylgalactosaminyltransferase 5; Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor.


ensembl_gene_id: Y39E4B.8.1
symbol: zig-8
gene_biotype: protein_coding
description:
  Zwei Ig domain protein zig-8; Together with zig-5, required postembryonically to maintain the position of ASI and ASH head neuron cell bodies and ventral nerve cord axons of PVQ, PVP and HSN neurons by preventing their displacement that could occur during body growth and movement. May act by reducing L1CAM-like protein sax-7 (long isoform) adhesion.


ensembl_gene_id: Y39E4B.9c.1
symbol: bre-2
gene_biotype: protein_coding
description:
  Beta-1,3-galactosyltransferase bre-2; Transfers N-acetylgalactosamine onto carbohydrate substrates (By similarity). Involved in susceptibility to pore-forming crystal toxins in conjunction with bre-1, bre-3, bre-4, and bre-5. Involved in resistance to the nematotoxic C.cinerea galectin Cgl2.


ensembl_gene_id: Y39G10AL.3.2
symbol: cdk-7
gene_biotype: protein_coding
description:
  Cyclin-dependent kinase 7; Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Required for maintaining chromosome ploidy. May phosphorylate the large subunit of RNA polymerase II, ama-1; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.


ensembl_gene_id: Y39G10AR.10.1
symbol: epg-2
gene_biotype: protein_coding
description:
  Ectopic P granules protein 2; Involved in autophagy. Thought to act as an adapter protein that brings PGL granules to autophagic structures containing lgg-1. Association with other adapters such as sepa-1 is required for the accumulation and degradation of germ cell specific P-granules by autophagy in somatic cells. This ensures exclusive localization of the P-granules in germ cells. May also play a role in the removal of sepa-1 from somatic cells.


ensembl_gene_id: Y39G10AR.14a.2
symbol: mcm-4
gene_biotype: protein_coding
description:
  DNA replication licensing factor mcm-4; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentia [...]


ensembl_gene_id: Y39G10AR.17.1
symbol: sydn-1
gene_biotype: protein_coding
description:
  Synaptic defective enhancer 1; Acts as a negative regulator of nuclear pre-mRNA 3'-end processing (mRNA polyadenylation) (Probable). Plays a role in tissue-specific expression of protein isoforms by regulating differential processing of pre-mRNA 3'-end (alternative polyadenylation). In neurons, regulates alternative polyadenylation of specific mRNAs including unc- 44 and dlk-1 by interacting with phosphatase ssup-72 and thus preventing ssup-72 dephosphorylation of RNA polymerase II subunit ama-1. Specifically, alters the usage of internal polyadenylation sites (PAS) to promote the prod [...]


ensembl_gene_id: Y39G10AR.18a.1
symbol: dot-1.1
gene_biotype: protein_coding
description:
  Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase, which in complex with zfp-1, methylates 'Lys-79' of histone H3 to activate transcription (Probable). During stress, the zfp-1-dot-1.1 complex also plays a role in the deubiquitination of histone H2B sites, which negatively modulates the RNA polymerase II-induced transcription of highly expressed genes. Involved in controlling tissue-specific gene expression, particularly in the epidermis.


ensembl_gene_id: Y39G10AR.2a.1
symbol: zwl-1
gene_biotype: protein_coding
description:
  Protein zwilch homolog; Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for chromosome segregation, the assembly of the dynein-dynactin and mdf-1- mdf-2 complexes onto kinetochores and spindle pole separation. Its function related to the spindle assembly machinery and kinetochore-microtubule attachments likely depends on its association in the mitotic RZZ complex. The RZZ complex recruits the spindly-like protein spdl-1 to kinetochores. To prevent irregular chromosome segregation, the complex also inhibits the attachment of [...]


ensembl_gene_id: Y39H10A.3a.1
symbol: mtm-9
gene_biotype: protein_coding
description:
  Myotubularin-related protein 9; May act as a regulatory subunit for mtm-6. In association with phosphatase mtm-6, plays a role in endosome trafficking probably by regulating phosphatidylinositol-3-phosphate levels. Regulates fluid phase endocytosis in coelomocytes. Regulates posterior migration of QL neuroblast descendants and the anterior migration of QR neuroblast descendants and HSN neurons during larval development probably by controlling Wnt ligand secretion through the regulation of sorting receptor mig-14 trafficking. Involved in the formation of correct synapse number in DA9 mo [...]


ensembl_gene_id: Y39H10A.7a.1
symbol: chk-1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase chk-1; Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. Required for checkpoint mediated cell cycle arrest in response to DNA damage in germline cells. Delays cell-cycle reentry of the Z2 and Z3 primordial germ cells in response to transcription-induced DNA damage as they emerge from cell cycle arrest in L1 larvae. Essential for embryogene [...]


ensembl_gene_id: Y40B10A.1a.1
symbol: lbp-9
gene_biotype: protein_coding
description:
  Fatty acid-binding protein homolog 9; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.


ensembl_gene_id: Y40B10A.8a.2
symbol: nhr-86
gene_biotype: protein_coding
description:
  Nuclear hormone receptor family member nhr-86; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family.


ensembl_gene_id: Y40B1B.6.1
symbol: spr-5
gene_biotype: protein_coding
description:
  Probable lysine-specific histone demethylase 1; Probable histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3 (By similarity). Participates in the transcriptional repression of the presenilin protein hop-1. May act via the formation of a multiprotein complex that remodel or modify the chromatin. Together wi [...]


ensembl_gene_id: Y40H4A.1b.1
symbol: gar-3
gene_biotype: protein_coding
description:
  Muscarinic acetylcholine receptor gar-3; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover (By similarity). Enhances the release of the neurotransmitter acetlycholine in cholinergic motor neurons, which in turn positively feeds back to depolarize body wall muscles and allows for the maintenance of normal body posture and locomotion.


ensembl_gene_id: Y41C4A.13.1
symbol: sup-1
gene_biotype: protein_coding
description:
  Protein SUP-1; May be involved in trafficking or stabilization of the vesicular acetylcholine transporter unc-17.


ensembl_gene_id: Y41C4A.14.1
symbol: mrt-2
gene_biotype: protein_coding
description:
  Cell cycle checkpoint protein RAD1 homolog mrt-2; May be a component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. Promotes DNA double strand break- induced cell cycle arrest and apoptosis, thereby playing a role in genome stability. Also required for telomere length maintenance and germline immortality. May possess 3'->5' double stranded DNA exonuclease activity (By similarity). Belongs to the Rad1 family.


ensembl_gene_id: Y41D4A.6d.1
symbol: Y41D4A.6
gene_biotype: protein_coding
description:
  Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Belongs to the amidase family. GatA subfamily.


ensembl_gene_id: Y41D4B.12a.1
symbol: set-23
gene_biotype: protein_coding
description:
  Probable histone-lysine N-methyltransferase set-23; Probable histone methyltransferase (By similarity). Required for embryonic development; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.


ensembl_gene_id: Y41D4B.13a.1
symbol: ced-2
gene_biotype: protein_coding
description:
  Cell death abnormality protein 2; Required for cell migration and engulfment of cell corpses but not for programmed cell death/apoptosis. Has a role in the migration of the 2 gonadal distal tip cells (DTCs).


ensembl_gene_id: Y41E3.10b.1
symbol: eef-1B.2
gene_biotype: protein_coding
description:
  Probable elongation factor 1-beta/1-delta 2; EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP.


ensembl_gene_id: Y41G9A.4b.1
symbol: gbb-1
gene_biotype: protein_coding
description:
  Gamma-aminobutyric acid type B receptor subunit 1; Component of a heterodimeric G-protein coupled receptor for GABA, formed by gbb-1 and gbb-2 (By similarity). Within the heterodimeric GABA receptor, only gbb-1 seems to bind agonists, while gbb-2 mediates coupling to G proteins (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (By similarity). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates po [...]


ensembl_gene_id: Y43C5A.6a.1
symbol: rad-51
gene_biotype: protein_coding
description:
  DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Underwinds duplex DNA.


ensembl_gene_id: Y43F4A.1a.1
symbol: Y43F4A.1
gene_biotype: protein_coding
description:
  Leishmanolysin-like peptidase; Essential for the coordination of mitotic progression, and also plays a role in cell migration.


ensembl_gene_id: Y43F4A.4.1
symbol: Y43F4A.4
gene_biotype: protein_coding
description:
  2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).


ensembl_gene_id: Y43F4B.3.1
symbol: set-25
gene_biotype: protein_coding
description:
  Histone-lysine N-methyltransferase set-25; Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using mono- and dimethylated H3 'Lys-9' as substrate. Acts redundantly with the methyltransferase met-2 to position chromosome arms at the nuclear lamina. Required for small-RNA-induced H3K9 methylation. Together with met-2, protects and stabilizes repeat-rich genomic regions by suppressing transcription- induced replication stress through methylation of H3K9.


ensembl_gene_id: Y43F4B.4.1
symbol: npp-18
gene_biotype: protein_coding
description:
  Nucleoporin SEH1; Probable component of the nuclear pore complex (NPC) which is involved in the trafficking of macromolecules between the cytoplasm and nucleus.


ensembl_gene_id: Y43F8C.10a.1
symbol: dmd-3
gene_biotype: protein_coding
description:
  Doublesex- and mab-3-related transcription factor dmd-3; Transcriptional activator which promotes male-specific development. Acts partially redundantly with the transcription factor mab-3 to coordinate tail tip cell fusion and retraction and thereby regulate male tail tip morphogenesis. This is most likely through the regulation of downstream effectors such as eff-1. May also negatively regulate the expression of other proteins implicated in male tail morphogenesis including nhr-25, vav-1 and arl-1 in tail tip cells. In males, plays a role in the development of ray A-neurons by negativ [...]


ensembl_gene_id: Y43H11AL.2a.1
symbol: laat-1
gene_biotype: protein_coding
description:
  Lysosomal amino acid transporter 1; Amino acid transporter that specifically mediates the pH- dependent export of the cationic amino acids arginine, histidine and lysine from lysosomes. May play a role in the degradation of autophagic substrates in autolysosomes by regulating lysosome function ; Belongs to the laat-1 family.


ensembl_gene_id: Y43H11AL.3a.1
symbol: pqn-85
gene_biotype: protein_coding
description:
  Nipped-B-like protein pqn-85; Probably plays a structural role in chromatin. Involved in sister chromatid cohesion, possibly by interacting with the cohesin complex (By similarity).


ensembl_gene_id: Y44A6D.4.1
symbol: sdf-9
gene_biotype: protein_coding
description:
  Protein sdf-9; Together with eak-4 and phosphatase eak-6, negatively regulates dauer larva formation downstream of insulin-like receptor daf-2 and in parallel of age-1, pdk-1 and akt-1.


ensembl_gene_id: Y44A6D.5.1
symbol: Y44A6D.5
gene_biotype: protein_coding
description:
  Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.


ensembl_gene_id: Y44A6E.1b.1
symbol: pbo-5
gene_biotype: protein_coding
description:
  Proton-gated ion channel subunit pbo-5; Forms a proton-gated ion channel with pbo-6 that is activated by acidification of the posterior coelomic space, leading to posterior body wall muscle contraction (pBoc) during the defecation cycle. Probably by regulating the defecation motor program, required for fatty acid uptake by intestinal cells. Does not bind neurotransmitters such as acetylcholine, gamma- aminobutyric acid, glycine, serotonin, glutamate or choline ; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily.


ensembl_gene_id: Y44F5A.1.1
symbol: Y44F5A.1
gene_biotype: protein_coding
description:
  WD repeat-containing protein 55; Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis. Belongs to the WD repeat WDR55 family.


ensembl_gene_id: Y45F10A.4.1
symbol: seld-1
gene_biotype: protein_coding
description:
  Probable selenide, water dikinase; Synthesizes selenophosphate from selenide and ATP. Belongs to the selenophosphate synthase 1 family. Class I subfamily.


ensembl_gene_id: Y45F10C.2.1
symbol: Y45F10C.2
gene_biotype: protein_coding
description:
  UPF0375 protein Y45F10C.2; Negatively regulates the egg-laying rate by promoting retention of fertilized eggs.


ensembl_gene_id: Y45F10D.13a.1
symbol: sorb-1
gene_biotype: protein_coding
description:
  Sorbin and SH3 domain-containing protein 1 homolog; Required for organization of sarcomeres in body wall muscles and for maintaining normal mitochondrial position in myocytes.


ensembl_gene_id: Y45F10D.3a.1
symbol: gly-10
gene_biotype: protein_coding
description:
  Putative polypeptide N-acetylgalactosaminyltransferase 10; May catalyze the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor.


ensembl_gene_id: Y45F10D.4.1
symbol: Y45F10D.4
gene_biotype: protein_coding
description:
  NifU_N domain-containing protein; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.


ensembl_gene_id: Y45F10D.9.1
symbol: sas-6
gene_biotype: protein_coding
description:
  Spindle assembly abnormal protein 6; Central scaffolding component of the centrioles ensuring their 9-fold symmetry. Required for centrosome biogenesis and duplication.


ensembl_gene_id: Y45F3A.3a.1
symbol: acdh-11
gene_biotype: protein_coding
description:
  Acyl-CoA dehydrogenase family member 11; Promotes adaption to elevated temperatures by regulating expression of the lipid desaturase, fat-7. Binds selectively and with high affinity to fatty acids with chain lengths from C10 to C12 and prevents them from activating fat-7 expression mediated by the nuclear hormone receptor nhr-49, leading to low levels of membrane lipid desaturation and membrane fluidity for adaption to heat.


ensembl_gene_id: Y45G12C.2a.1
symbol: gst-10
gene_biotype: protein_coding
description:
  Glutathione S-transferase P 10; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Responsible for approximately one-third of 4-hydroxy-2-nonenal conjugation (Ref.1,. May play a role in the detoxification of reactive oxygen species produced during pathogenic bacterial infection. Belongs to the GST superfamily. Pi family.


ensembl_gene_id: Y46G5A.2.1
symbol: cox-10
gene_biotype: protein_coding
description:
  Protoheme IX farnesyltransferase, mitochondrial; Converts protoheme IX and farnesyl diphosphate to heme O. Belongs to the ubiA prenyltransferase family.


ensembl_gene_id: Y46G5A.30.1
symbol: snf-5
gene_biotype: protein_coding
description:
  Sodium-dependent transporter snf-5; Sodium-dependent amino acid transporter that mediates the uptake of the L-enantiomers of various amino acids, including L-proline and L-methionine, and also of acidic amino acids such as L-glutamic acid and L-aspartic acid  (Probable). May additionally have a role in potassium-dependent amino acid absorption. In response to the availability of amino acid nutrients, may play a role in dauer formation. May play a role in promoting fertility. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.


ensembl_gene_id: Y46G5A.31.1
symbol: gsy-1
gene_biotype: protein_coding
description:
  Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan; Belongs to the glycosyltransferase 3 family.


ensembl_gene_id: Y46G5A.4.1
symbol: snrp-200
gene_biotype: protein_coding
description:
  Putative U5 small nuclear ribonucleoprotein 200 kDa helicase; Putative RNA helicase involved in the second step of RNA splicing; Belongs to the helicase family. SKI2 subfamily.


ensembl_gene_id: Y46H3A.6a.1
symbol: gly-7
gene_biotype: protein_coding
description:
  Probable N-acetylgalactosaminyltransferase 7; Probable glycopeptide transferase involved in O-linked oligosaccharide biosynthesis. Glycopeptide transferases catalyze the transfer of an N-acetyl-D-galactosamine residue to an already glycosylated peptide (By similarity). In contrast to other members of the family, it does not act as a peptide transferase that transfers GalNAc onto serine or threonine residue on peptides that have been tested. Some peptide transferase activity is however not excluded, considering that its appropriate peptide substrate may remain unidentified; Belongs to t [...]


ensembl_gene_id: Y47D3A.16.1
symbol: rsks-1
gene_biotype: protein_coding
description:
  Ribosomal protein S6 kinase beta; Serine/threonine-protein kinase which regulates mRNA translation. Negatively regulates lifespan and resistance to starvation, oxidative stress, protein aggregation and P.aeruginosa-mediated infection. May regulate these processes by preventing the activation of transcription factor hif-1. Required, probably downstream of let-363/TOR, for the establishment of the proper number of germline progenitors by promoting cell cycle progression and preventing differentiation during larval development. Regulates germ cell size. In addition required for sperm prod [...]


ensembl_gene_id: Y47D3A.23a.1
symbol: gly-9
gene_biotype: protein_coding
description:
  Probable N-acetylgalactosaminyltransferase 9; Probable glycopeptide transferase involved in O-linked oligosaccharide biosynthesis. Glycopeptide transferases catalyze the transfer of an N-acetyl-D-galactosamine residue to an already glycosylated peptide (By similarity). In contrast to other members of the family, it does not act as a peptide transferase that transfers GalNAc onto serine or threonine residue on peptides that have been tested. Some peptide transferase activity is however not excluded, considering that its appropriate peptide substrate may remain unidentified.


ensembl_gene_id: Y47D3A.26b.1
symbol: smc-3
gene_biotype: protein_coding
description:
  Structural maintenance of chromosomes protein 3; Involved in chromosome cohesion during cell cycle and in DNA repair. Involved in the repair of double strand breaks during mitosis and meiosis. Required for chromosome segregation during mitosis. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped (By similarity). At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chrom [...]


ensembl_gene_id: Y47D3A.6a.1
symbol: tra-1
gene_biotype: protein_coding
description:
  Sex-determining transformer protein 1; Plays a major role in controlling sexual phenotype. Terminal global regulator in a well-characterized cascade of sex-determining genes. Promotes female development. Interacts with tra-2 to promote spermatogenesis. Promotes spermatogenesis through the Tip60 HAT complex and by regulating the expression of genes, such as fog-3, required for male development (By similarity). Association with chromatin and at the fog-3 promoter requires wdr-5.1, and may also require wdr-5.2. With trr-1, activates the fog-3 gene to determine sperm/oocyte cell fate (By s [...]


ensembl_gene_id: Y47D3B.10.1
symbol: dpy-18
gene_biotype: protein_coding
description:
  Prolyl 4-hydroxylase subunit alpha-1; Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins; Belongs to the P4HA family.


ensembl_gene_id: Y47D3B.11.1
symbol: plr-1
gene_biotype: protein_coding
description:
  Probable E3 ubiquitin-protein ligase plr-1; Probable E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled (By similarity). Acts on both canonical and non- canonical Wnt signaling pathway (By similarity). Plays a role in the migration and axon guidance of different neuronal cell types including CAN, HSN, AVK and AVG. Promotes the differentiation and regulates the anteroposterior polarity of AVG unpaired interneurons by sequestering the [...]


ensembl_gene_id: Y47D7A.16a.1
symbol: rft-1
gene_biotype: protein_coding
description:
  Riboflavin transporter rft-1; Riboflavin transporter. Riboflavin transport is Na(+)- independent but pH-sensitive; Belongs to the riboflavin transporter family.


ensembl_gene_id: Y47G6A.10.1
symbol: spg-7
gene_biotype: protein_coding
description:
  AFG3-like protein spg-7; Acts as a component of the m-AAA protease complex which is an ATP-dependent metalloprotease mediating degradation of non-assembled mitochondrial inner membrane proteins (By similarity). The complex is necessary for the assembly of mitochondrial respiratory chain and ATPase complexes (By similarity). Functions both in post-translational assembly and in the turnover of mistranslated or misfolded polypeptides. Plays a role in male tail tip morphogenesis. In the C-terminal section; belongs to the peptidase M41 family.


ensembl_gene_id: Y47G6A.12.2
symbol: sep-1
gene_biotype: protein_coding
description:
  Separin homolog sep-1; Cysteine protease, which plays a central role in homologous chromosome separation during meiosis I and in sister chromatid separation during embryonic mitosis. Promotes chromosome/sister chromatid segregation by cleaving the scc-1 (mitosis) and rec-8 (meiosis) subunits of the cohesin complex at the onset of anaphase (Probable). May cleave histone H3-like protein cpar-1 during meiosis I metaphase- anaphase transition. Promotes cortical granule exocytosis after oocyte fertilization during the first meiotic anaphase. Essential for embryonic cytokinesis by regulating [...]


ensembl_gene_id: Y47G6A.4.1
symbol: rde-10
gene_biotype: protein_coding
description:
  RNA interference defective protein 10; In complex with rde-11, required in the endogenous and exogenous siRNA pathway for biogenesis and accumulation of secondary small interfering RNA (siRNA) intermediates, such as 22G-siRNAs derived from ergo-1 targets.


ensembl_gene_id: Y47G6A.8.1
symbol: crn-1
gene_biotype: protein_coding
description:
  Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as  [...]


ensembl_gene_id: Y47H9C.4a.1
symbol: ced-1
gene_biotype: protein_coding
description:
  Cell death abnormality protein 1; Involved in programmed cell death, also called apoptosis, in both somatic and germ cells. Acts by recruiting ced-6 to phagosomes which enables actin-dependent cytoskeletal reorganization and subsequent engulfment of the apoptotic cell corpse. Has a role in the association of ppk-3 and rab-7 with the phagosomal surface which is necessary for the incorporation of lysosomes to phagosomes during phagosome maturation. Activates the expression of unfolded protein response genes, which are involved in the immune response to live bacteria.


ensembl_gene_id: Y47H9C.6a.1
symbol: csp-3
gene_biotype: protein_coding
description:
  Non-catalytic caspase homolog csp-3; Non-catalytic caspase homolog which does not contain the region necessary for caspase activity. Acts as an inhibitor of caspase ced-3 zymogen autoactivation and delays ced-4- induced ced-3 processing. Has no effect on active ced-3. Probably by preventing ced-3 activation, protects cells, whose fate is to live, from apoptosis during embryonic and larval development ; Belongs to the peptidase C14A family.


ensembl_gene_id: Y48A5A.1.1
symbol: Y48A5A.1
gene_biotype: protein_coding
description:
  Protein SHQ1 homolog; Required for the quantitative accumulation of H/ACA ribonucleoproteins (RNPs).


ensembl_gene_id: Y48A6A.1.1
symbol: zig-5
gene_biotype: protein_coding
description:
  Zwei Ig domain protein zig-5; Together with zig-8, required postembryonically to maintain the position of ASI and ASH head neuron cell bodies and ventral nerve cord axons of PVQ, PVP and HSN neurons by preventing their displacement that could occur during body growth and movement. May act by reducing L1CAM-like protein sax-7 (long isoform) adhesion.


ensembl_gene_id: Y48A6B.11b.1
symbol: rsa-2
gene_biotype: protein_coding
description:
  Regulator of spindle assembly protein 2; Recruits rsa-1 and, thereby, phosphatase let-92/paa-1 complex to the centrosomes. Recruits sys-1/beta-catenin to mitotic centrosomes during the first embryonic cell divisions.


ensembl_gene_id: Y48A6B.3.1
symbol: Y48A6B.3
gene_biotype: protein_coding
description:
  Putative H/ACA ribonucleoprotein complex subunit 2-like protein; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity).


ensembl_gene_id: Y48A6B.6b.1
symbol: kvs-4
gene_biotype: protein_coding
description:
  Probable voltage-gated potassium channel subunit kvs-4; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes.


ensembl_gene_id: Y48B6A.1.1
symbol: Y48B6A.1
gene_biotype: protein_coding
description:
  Ribosome biogenesis protein BOP1 homolog; Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit; Belongs to the WD repeat BOP1/ERB1 family.


ensembl_gene_id: Y48B6A.11.1
symbol: jmjd-2
gene_biotype: protein_coding
description:
  Lysine-specific demethylase 4; Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. Involved in the negative regulation of lifespan in a germline-dependent fashion.


ensembl_gene_id: Y48B6A.13b.2
symbol: Y48B6A.13
gene_biotype: protein_coding
description:
  Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes.


ensembl_gene_id: Y48B6A.3.1
symbol: xrn-2
gene_biotype: protein_coding
description:
  5'-3' exoribonuclease 2 homolog; Possesses 5'->3' exoribonuclease activity. Plays a role in maintenance of steady-state concentration and turnover of microRNAs (miRNA) by degradation of mature miRNA. Degradation role is enhanced when in complex with paxt-1. Partially redundant to xrn-1 in miRNA guide strand degradation. Implicated in differential regulation of mRNAs such as let-7 by controlling the accumulation of mature miRNA. Positively regulates molting of the pharyngeal cuticle.


ensembl_gene_id: Y48B6A.4.1
symbol: eat-2
gene_biotype: protein_coding
description:
  Neuronal acetylcholine receptor subunit eat-2; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane (By similarity). Nicotinic acetylcholine receptor in the MC pharyngeal motor neuron involved in pharyngeal pumping. Has a role in the determination of life span possibly via calorific restriction which affects growth rate, although this is independent of metabolic activity. Plays a role in the defense against the accumulation of ingested live pathogenic  [...]


ensembl_gene_id: Y48C3A.14a.1
symbol: Y48C3A.14
gene_biotype: protein_coding
description:
  DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.


ensembl_gene_id: Y48C3A.7.1
symbol: mac-1
gene_biotype: protein_coding
description:
  Protein mac-1; Probably together with ced-9, plays a modest role in preventing ced-4 and caspase ced-3-mediated apoptosis. Belongs to the AAA ATPase family.


ensembl_gene_id: Y48C3A.8a.1
symbol: sam-10
gene_biotype: protein_coding
description:
  Single-stranded DNA-binding protein homolog sam-10; Involved cell autonomously in PLM neuron pre-synaptic differentiation by negatively regulating prk-2 expression and in neurite branch positioning.


ensembl_gene_id: Y48D7A.2.2
symbol: flp-18
gene_biotype: protein_coding
description:
  FMRFamide-like neuropeptide 18; Together with flp-1, plays a homeostatic role by acting on the GABAergic neural transmission at neuromuscular junctions to prevent overexcitation of the locomotor circuit. Plays a role in the navigational capacity of sperm and the targeting of sperm derived from males to the fertilization site in the uterus of hermaphrodites. [EMPGVLRF-amide]: Inhibits the activity of dissected pharyngeal myogenic muscle system.


ensembl_gene_id: Y48E1B.12.1
symbol: csc-1
gene_biotype: protein_coding
description:
  Chromosome segregation and cytokinesis defective protein 1; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of chromosome segregation and cytokinesis during mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation. In the complex, it may be required to direct the Aurora B/air-2 to centromeric DNA; Belongs to the borealin family. Highly divergent.


ensembl_gene_id: Y48E1B.13a.1
symbol: csp-1
gene_biotype: protein_coding
description:
  Caspase A subunit p14; Cysteine protease which, in vitro, cleaves itself and caspase ced-3 into their mature active forms. Also cleaves, in vitro, inactive caspase csp-2 isoform b. Required maternally to induce apoptosis in a subset of cells fated to die during embryogenesis, mostly independently of the ced-9, ced-4 and ced-3 canonical apoptosis pathway. Involved in the degeneration of dopaminergic CEP neurons in response to high Mn(2+) levels.


ensembl_gene_id: Y48G1A.3.1
symbol: daf-25
gene_biotype: protein_coding
description:
  Dauer abnormal formation protein 25; May be involved in the trafficking and dendritic transport of signaling proteins, such as the receptor-type guanylate cyclases gcy-12 and daf-11, to the cilia. In ciliated sensory neurons, required for the calcium flux to the cytoplasm in response to onset and removal of a nitric oxide (NO) stimulus and is thereby required for the behavioral avoidance response to NO-producing organisms like P.aeruginosa.


ensembl_gene_id: Y48G1BL.2a.1
symbol: atm-1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling in the presence of DNA double strand breaks (DSBs) and other forms of DNA damage induced by ionizing radiation and other genotoxic stresses such as UV. Plays a role in maintaining genome stability. Belongs to the PI3/PI4-kinase family. ATM subfamily.


ensembl_gene_id: Y48G1C.2b.1
symbol: csk-1
gene_biotype: protein_coding
description:
  Tyrosine-protein kinase csk-1; Non-receptor tyrosine-protein kinase which plays a role in pharynx function by regulating pumping and the orientation of pharyngeal muscle fibers, independently of src-1 and src-2. May phosphorylate and thereby negatively regulate src-1 and src-2 activities.


ensembl_gene_id: Y48G1C.4a.1
symbol: pgs-1
gene_biotype: protein_coding
description:
  CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin; Belongs to the CDP-alcohol phosphatidyltransferase class-II family.


ensembl_gene_id: Y48G8AL.6.2
symbol: smg-2
gene_biotype: protein_coding
description:
  Regulator of nonsense transcripts 1; RNA-dependent helicase and ATPase required for nonsense- mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. The formation of an smg-2-3-4 surveillance complex is believed to activate NMD (By similarity).


ensembl_gene_id: Y49A3A.2.4
symbol: vha-13
gene_biotype: protein_coding
description:
  V-type proton ATPase catalytic subunit A; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (Probable). V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells (Probable). Required along with other vacuolar ATPase components for the removal of protein aggregates which form in immature oocytes in the distal gonad. This removal occurs as the oocytes mature and move to the proximal gonad, is triggered by the introduction of sperm through mating and occurs before fertilization. The introduction of sperm triggers V-A [...]


ensembl_gene_id: Y49A3A.5.1
symbol: cyn-1
gene_biotype: protein_coding
description:
  Peptidyl-prolyl cis-trans isomerase 1; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.


ensembl_gene_id: Y49E10.1.1
symbol: rpt-6
gene_biotype: protein_coding
description:
  26S proteasome regulatory subunit 8; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair (By similarity). Belongs to the heterohexameric ring of AAA (ATPases assoc [...]


ensembl_gene_id: Y49E10.11c.1
symbol: tat-1
gene_biotype: protein_coding
description:
  Phospholipid-transporting ATPase tat-1; Transports phosphatidylserine from the outer to the inner leaflet of the plasma membrane, thereby maintaining the enrichment of this phospholipid in the inner leaflet. Ectopic exposure of phosphatidylserine on the cell surface may result in removal of living cells by neighboring phagocytes. Regulation of the phosphatidylserine distribution in plasma membranes is likely to help in the maintainence and control of the membrane surface charge. Plays a role in the formation of the tubular membrane structure and in membrane trafficking and is specifica [...]


ensembl_gene_id: Y49E10.14a.1
symbol: pie-1
gene_biotype: protein_coding
description:
  Pharynx and intestine in excess protein 1; Maternally provided PIE-1 is required for germline cell fate determination. Functions as a repressor of RNA polymerase II-dependent gene expression in the developing germline. Required for expression of nos-2 in P4 germline blastomere cells. Inhibits the histone deacetylase activity of hda-1. Represses transcriptional activation of cdk-9 and cit-1.1, which are members of the P-TEFb complex.


ensembl_gene_id: Y49E10.15.1
symbol: snr-6
gene_biotype: protein_coding
description:
  Probable small nuclear ribonucleoprotein E; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family.


ensembl_gene_id: Y49E10.19.1
symbol: ani-1
gene_biotype: protein_coding
description:
  Anillin-like protein 1; Required for contractile events in embryos that occur prior to mitosis, such as cortical ruffling and pseudocleavage. Promotes membrane ruffling by organizing cortical patches of septins and myosin II. Not generally required for cytokinesis in mitotic cells. Required for the asymmetric cleavage events that extrude the two polar bodies during oocyte meiosis. Not required for meiotic contractile ring assembly, initiation or closure but is required for the transformation of the contractile ring from a disk above the spindle to a tube around the spindle midzone. Pro [...]


ensembl_gene_id: Y49E10.3a.1
symbol: pph-4.2
gene_biotype: protein_coding
description:
  Serine/threonine-protein phosphatase 4 catalytic subunit 2; Protein phosphatase which seems to be involved in larval development but not essential for embryogenesis.


ensembl_gene_id: Y49F6B.4.1
symbol: smu-2
gene_biotype: protein_coding
description:
  Smu-2 suppressor of mec-8 and unc-52 protein; Auxiliary spliceosomal protein that regulates selection of alternative splice sites in a small set of target pre-mRNA species (Probable). Selectively regulates alternative splicing of unc-52 exon 17. Thus, smu-2 mutants selectively suppress the effects of unc-52 nonsense mutations in exon 17 by promoting the accumulation of unc-52 isoforms that lack exon 17. In contrast, smu-2 mutants do not suppress the effects of an unc-52 mutation that affects the 5' splice site of exon 16. Required for normal accumulation of smu-1. Belongs to the RED family.


ensembl_gene_id: Y50D4C.4a.1
symbol: sqv-6
gene_biotype: protein_coding
description:
  Xylosyltransferase sqv-6; Catalyzes the first step in biosynthesis of glycosaminoglycan. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein. Initial enzyme in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans in fibroblasts and chondrocytes. Required for vulval morphogenesis and zygotic cytokinesis, suggesting that glycosaminoglycans play a central role in vulval morphogenesis.


ensembl_gene_id: Y50D7A.6.3
symbol: klp-20
gene_biotype: protein_coding
description:
  Kinesin-like protein klp-20; Component of the kinesin II motor complex (composed of kap-1 and the heterodimeric motor proteins klp-11 and klp-20) which is required for intraflagellar transport (IFT). Heterodimerizes with klp-11 to form a 'processive' molecular motor upon IFT cargo binding, which, within the kinesin II motor complex, binds to and moves along microtubules in a unidirectional manner (without dissociation of the heterodimer), and in turn, is responsible for the IFT of cargo. Specifically, the kinesin II motor complex, together with the kinesin motor protein osm-3 moves alo [...]


ensembl_gene_id: Y50D7A.7.1
symbol: ads-1
gene_biotype: protein_coding
description:
  Alkyldihydroxyacetonephosphate synthase; Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids; Belongs to the FAD-binding oxidoreductase/transferase type 4 family.


ensembl_gene_id: Y50E8A.4a.1
symbol: unc-61
gene_biotype: protein_coding
description:
  Septin-type G domain-containing protein; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.


ensembl_gene_id: Y50E8A.6.1
symbol: Y50E8A.6
gene_biotype: protein_coding
description:
  Glycerol-3-phosphate dehydrogenase; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.


ensembl_gene_id: Y51A2D.15a.1
symbol: grdn-1
gene_biotype: protein_coding
description:
  Girdin homolog; Scaffolding protein that plays a role in ciliogenesis, cilium positioning and dendrite anchoring in sensory amphid neurons including AWB, AWA, AWC, ADL and ASI and the phasmid neurons PHA and PHB. Its role in cilium positioning may be through regulation of the localization of cell adhesion proteins such as the apical junction protein ajm-1, and the ciliary scaffolding protein Rootletin/che-10. Belongs to the CCDC88 family.


ensembl_gene_id: Y51A2D.19d.1
symbol: slo-1
gene_biotype: protein_coding
description:
  Calcium-activated potassium channel slo-1; Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Essential for the regulation of neurotransmitter release at synapses.


ensembl_gene_id: Y51H1A.6a.1
symbol: mcd-1
gene_biotype: protein_coding
description:
  Modifier of cell death; Promotes programmed cell death. Its role in programmed cell death may be in conjunction with cell cycle regulatory factor efl-1 and the synthetic multivulva class B proteins dpl-1 and lin-35, and is independent of the ced-1, ced-8 and ced-9 pathways.


ensembl_gene_id: Y51H4A.12.1
symbol: set-26
gene_biotype: protein_coding
description:
  Histone-lysine N-methyltransferase set-26; Histone methyltransferase that mediates trimethylation of 'Lys-9' of histone H3 in vitro. Involved in transcriptional regulation. Plays a role in the negative regulation of lifespan and in heat resistance. Together with set-9, negatively regulates lifespan in a germline-independent, partially daf-16-dependent fashion. Together with set-9, plays a role in germline development and maintenance and might play a role in the restriction of the trimethylation mark on histone H3 'Lys-4'(H3K4me3) to target genes specifically in the germline. Together w [...]


ensembl_gene_id: Y51H4A.17a.1
symbol: sta-1
gene_biotype: protein_coding
description:
  Signal transducer and activator of transcription 1; Carries out a dual function: signal transduction and activation of transcription. Activated STAT proteins play a role in repression of dauer formation. Neuronal expression is held in check by negative signals through the TGF-beta pathway that target the daf-3 transcription factor.


ensembl_gene_id: Y51H4A.3a.1
symbol: rho-1
gene_biotype: protein_coding
description:
  Ras-like GTP-binding protein rhoA; Required for ventral migration of epidermal cells during ventral enclosure in the embryo and for cell elongation. Also required for ventral migration of P cells during larval development. Involved in asymmetric spindle positioning during anaphase and establishment of cell polarity during embryo development. In adults, involved in regulation of multiple processes including locomotion, pharyngeal pumping, fecundity, ovulation, defecation and body morphology. In body wall muscles, regulates organization of myosin thick filaments downstream of unc-89. Ass [...]


ensembl_gene_id: Y51H7C.6a.1
symbol: cogc-4
gene_biotype: protein_coding
description:
  Conserved oligomeric Golgi complex subunit 4; Required for normal Golgi function; Belongs to the COG4 family.


ensembl_gene_id: Y52B11A.2a.1
symbol: impt-1
gene_biotype: protein_coding
description:
  Protein IMPACT homolog; Translational regulator that ensures constant high levels of translation under amino acid starvation. Plays a role as a negative regulator of the gcn-2 kinase activity; impairs gcn-1-mediated gcn-2 activation, and hence gcn-2-mediated eIF-2-alpha phosphorylation and subsequent down-regulation of protein synthesis in amino acid-starved cells. Plays a role in differentiation of neuronal cells by stimulating neurite outgrowth; Belongs to the IMPACT family.


ensembl_gene_id: Y52D3.1a.1
symbol: strd-1
gene_biotype: protein_coding
description:
  STE20-related kinase adapter protein strd-1; Pseudokinase which may act as an adapter for kinases sad-1 and par-4 and thereby is involved in several developmental processes. Regulates cell-autonomously both neuronal polarity and synaptic organization when bound to sad-1. Required for sad-1 localization to synapses. Required to establish germline stem cell (GSC) quiescence during dauer development, to promote cell shedding during embryogenesis and to control asymmetric cell division of the Q.p neuroblast lineage, probably when bound to par-4. May be involved in maintaining the integrity [...]


ensembl_gene_id: Y53C12A.1.1
symbol: wee-1.3
gene_biotype: protein_coding
description:
  Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase wee-1.3; Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase during oocyte maturation. Required for oocyte maturation, embryonic development, germline proliferation and initiation of meiosis during spermatogenesis. Required for chromosome structure during mitosis and negative regulation of nuclear envelope breakdown. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.


ensembl_gene_id: Y53C12A.4.2
symbol: mop-25.2
gene_biotype: protein_coding
description:
  MO25-like protein 2; Regulates asymmetric cell division in Q.p neuroblast lineage. Plays a role in cell shedding during embryogenesis.


ensembl_gene_id: Y53C12B.5a.1
symbol: mab-3
gene_biotype: protein_coding
description:
  Protein male abnormal 3; Transcription factor which binds the DNA motif 5'- [CGA][TCA][TA]ACAATGT[AT][TGA]C-3', probably as a monomer. Acts partially redundantly with the transcription factor dmd-3 to coordinate tail tip cell fusion and retraction and thereby regulate male tail tip morphogenesis. Promotes male-specific development of two tissues, the peripheral nervous system and the intestine. In the peripheral nervous system, directs differentiation of sensory ray neuroblasts into peripheral sense organs. In the intestine, causes repression of vitellogenin gene transcription.


ensembl_gene_id: Y53F4B.13a.1
symbol: Y53F4B.13
gene_biotype: protein_coding
description:
  Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1; S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG- capped mRNA to produce m(7)GpppNmp (cap1). Cap1 modification is linked to higher levels of translation.


ensembl_gene_id: Y54E10A.11.1
symbol: Y54E10A.11
gene_biotype: protein_coding
description:
  E3 ubiquitin-protein ligase listerin; E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Ubiquitination leads to vcp/p97 recruitment for extraction and degradation of the incomplete translation product; Belongs to the LTN1 family.


ensembl_gene_id: Y54E10BL.6.1
symbol: mek-2
gene_biotype: protein_coding
description:
  Dual specificity mitogen-activated protein kinase kinase mek-2; Functions in the let-60 Ras signaling pathway; acts downstream of lin-45 raf kinase, but before the sur-1/mpk-1 gene product in controlling vulval cell differentiation. Required for progression of developing oocytes through the pachytene stage. Plays a role in responses to M.nematophilum- mediated bacterial infection by promoting tail swelling and preventing constipation. Involved in fluid homeostasis. Positively regulates lifespan upstream of mpk-1.


ensembl_gene_id: Y54E2A.11a.1
symbol: eif-3.B
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 3 subunit B; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.


ensembl_gene_id: Y54E2A.2.1
symbol: smg-9
gene_biotype: protein_coding
description:
  Protein smg-9; Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Probable component of kinase complex containing smg-1 and recruited to stalled ribosomes. Belongs to the SMG9 family.


ensembl_gene_id: Y54E2A.3.1
symbol: tac-1
gene_biotype: protein_coding
description:
  Transforming acid coiled-coil-containing protein 1; Involved in microtubule formation, polymerization and assembly, regulating microtubule nucleation and length. Plays a role in pronuclear migration and mitotic and meiotic spindle elongation during early embryogenesis. In complex with zyg-9, functions during the early stages of embryonic development to regulate microtubule assembly throughout the cell cycle. Specifically, the complex is required for the formation and growth of astral microtubules and spindle microtubules during mitotic spindle assembly. At anaphase, the complex is requ [...]


ensembl_gene_id: Y54E5A.1.1
symbol: ttm-5
gene_biotype: protein_coding
description:
  Putative sphingolipid delta(4)-desaturase/C4-monooxygenase; Bifunctional enzyme which acts as both a sphingolipid delta(4)-desaturase and a sphingolipid C4-monooxygenase.


ensembl_gene_id: Y54E5B.3a.1
symbol: let-49
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 7; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required  [...]


ensembl_gene_id: Y54E5B.4.1
symbol: ubc-16
gene_biotype: protein_coding
description:
  Ubiquitin-conjugating enzyme E2 W; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (By similarity). Together with ubc-18, required for the ubiquitination of membranous organelles, and the removal of paternal mitochondria from early embryos.


ensembl_gene_id: Y54F10AM.2a.1
symbol: feh-1
gene_biotype: protein_coding
description:
  Protein Fe65 homolog; Modulates pharyngeal pumping activity, at least in part by regulating expression of the acetylcholinesterase genes ace-1 and ace-2.


ensembl_gene_id: Y54F10AM.4a.1
symbol: ceh-44
gene_biotype: protein_coding
description:
  Homeobox protein cut-like ceh-44; Probable DNA-binding regulatory protein involved in cell-fate specification; Belongs to the CUT homeobox family.


ensembl_gene_id: Y54F10AM.5.1
symbol: Y54F10AM.5
gene_biotype: protein_coding
description:
  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.


ensembl_gene_id: Y54F10AM.8.1
symbol: Y54F10AM.8
gene_biotype: protein_coding
description:
  Putative phospholipase B-like 3; Putative phospholipase; Belongs to the phospholipase B-like family.


ensembl_gene_id: Y54F10BM.13.1
symbol: Y54F10BM.13
gene_biotype: protein_coding
description:
  Uncharacterized protein; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.


ensembl_gene_id: Y54G11A.10a.1
symbol: lin-7
gene_biotype: protein_coding
description:
  Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family.


ensembl_gene_id: Y54G11A.11.2
symbol: Y54G11A.11
gene_biotype: protein_coding
description:
  Transcription elongation factor 1 homolog; Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions. Belongs to the ELOF1 family.


ensembl_gene_id: Y54G11A.13a.1
symbol: ctl-3
gene_biotype: protein_coding
description:
  Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.


ensembl_gene_id: Y54G11A.5.2
symbol: ctl-2
gene_biotype: protein_coding
description:
  Peroxisomal catalase 1; Peroxisomal catalase involved in the oxidative stress response serving to protect cells from toxicity. Plays a role in maintaining normal lifespan. Plays a role in regulating the response to pathogens such as E.faecalis.


ensembl_gene_id: Y54G11A.6.2
symbol: ctl-1
gene_biotype: protein_coding
description:
  Catalase-2; Catalase involved in the oxidative stress response serving to protect cells from toxicity (Probable). For instance plays a role in defending against oxidative damage induced by excessive copper stress. Not required for maintaining normal lifespan.


ensembl_gene_id: Y54G2A.17b.2
symbol: nprt-1
gene_biotype: protein_coding
description:
  Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Helps prevent cellular oxidative stress via its role in NAD biosynthesis; Belongs to the NAPRTase family.


ensembl_gene_id: Y54G2A.23.1
symbol: manf-1
gene_biotype: protein_coding
description:
  Mesencephalic astrocyte-derived neurotrophic factor homolog; Inhibits endoplasmic reticulum (ER) stress response (By similarity). Retained in the ER under normal conditions and is up- regulated and secreted by the ER in response to ER stress and hypoxia (By similarity). Following secretion by the ER, directly binds to 3-O- sulfogalactosylceramide, a lipid sulfatide in the outer cell membrane of target cells. Sulfatide binding promotes its cellular uptake by endocytosis, and is required for its role in alleviating ER stress under ER stress conditions (By similarity). Has a neuroprotecti [...]


ensembl_gene_id: Y54G2A.31.1
symbol: ubc-13
gene_biotype: protein_coding
description:
  Ubiquitin-conjugating enzyme E2 13; Involved in protein ubiquitination, but has no ubiquitin ligase activity on its own. The uev-1-ubc-13 heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. Involved in sorting Lys-63-linked polyubiquitinated maternal membrane proteins for degradation by targeting to multivesicular bodies. May be involved in the ubiquitination and growth of intracellular polyglutamine protein aggregates. May have a role in AMPA-type glutamate receptor trafficking in neurons.


ensembl_gene_id: Y54G9A.6.1
symbol: bub-3
gene_biotype: protein_coding
description:
  Mitotic checkpoint protein bub-3; Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments of chromosomes. Necessary for expression and kinetochore localization of bub-1. Plays a role in synapsis checkpoint signaling inducing apoptosis in response to unsynapsed chromosomes and thus controlling chromosomal segregation during oocyte meiosis.


ensembl_gene_id: Y54H5A.4.1
symbol: oxy-4
gene_biotype: protein_coding
description:
  Probable cytosolic Fe-S cluster assembly factor oxy-4; Component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for maturation of extramitochondrial Fe/S proteins (By similarity); Belongs to the NARF family.


ensembl_gene_id: Y55B1BM.1a.1
symbol: stim-1
gene_biotype: protein_coding
description:
  Stromal interaction molecule 1; Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor which upon Ca(2+) depletion, activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit, orai-1. Essential for Ca (2+) and IP3-dependent contractile activity of gonad sheath cells and spermatheca. Essential for fertility. Does not play a role in posterior body wall muscle contraction (pBoc) rhythmicity, intestinal cell oscillatory Ca(2+) signaling or intestinal ER Ca(2+) hemostasis.


ensembl_gene_id: Y55D5A.3.1
symbol: Y55D5A.3
gene_biotype: protein_coding
description:
  N-acylethanolamine-hydrolyzing acid amidase subunit alpha; Degrades bioactive fatty acid amides, such as N- palmitoylethanolamine, to ethanolamine and free fatty acids. Belongs to the acid ceramidase family.


ensembl_gene_id: Y55D5A.5c.2
symbol: daf-2
gene_biotype: protein_coding
description:
  Insulin-like receptor subunit alpha; Insulin receptor-like tyrosine kinase which regulates metabolism, controls longevity and prevents developmental arrest at the dauer stage. Binding of INS family members may either stimulate, or antagonize, association of the receptor with downstream mediators such as pdk-1 and age-1. Required for germline progenitor proliferation during larval development. Required for the response to environmental stimuli such as food, pheromone, and temperature. Negatively regulates resistance to UV and oxidative stress. Role in immune function and pathogen resist [...]


ensembl_gene_id: Y55D9A.1b.1
symbol: efa-6
gene_biotype: protein_coding
description:
  Exchange factor for Arf-6; Guanine nucleotide exchange factor for arf-6 (By similarity). Involved in response to injury in mechanosensory neurons. Inhibits axon regrowth via microtubule dynamics, possibly by inducing axonal microtubule catastrophes. Limits microtubule growth near the cellular cortex of early embryonic cells.


ensembl_gene_id: Y55F3AM.1.1
symbol: mrps-25
gene_biotype: protein_coding
description:
  Probable 28S ribosomal protein S25, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mS25 family.


ensembl_gene_id: Y55F3AM.15.1
symbol: csn-4
gene_biotype: protein_coding
description:
  COP9 signalosome complex subunit 4; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. The CSN complex plays an essential role in embryogenesis and oogenesis and is required to regulate microtubule stability in the early embryo. Mediates mei-3/katanin targeting for degradation at the meiosis to mi [...]


ensembl_gene_id: Y55F3AR.3a.1
symbol: cct-8
gene_biotype: protein_coding
description:
  T-complex protein 1 subunit theta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity). Required for correct subcellular localization of pgl-1; Belongs to the TCP-1 chaperonin family.


ensembl_gene_id: Y55F3BR.8a.1
symbol: lem-4
gene_biotype: protein_coding
description:
  Ankyrin repeat and LEM domain-containing protein 2 homolog; Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of baf-1 during mitotic exit. Coordinates the control of baf-1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of baf-1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly. It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex.


ensembl_gene_id: Y56A3A.12a.2
symbol: faah-4
gene_biotype: protein_coding
description:
  Monoglyceride lipase faah-4; Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2- arachidonoylglycerol (2-AG), and thereby regulates the degradation of endocannabinoid-related monoacylglycerides. Also hydrolyzes arachidonoyl ethanolamide (anandamide, or AEA), but with low efficiency. Plays a role in the regulation of longevity and resistance to oxidative stress. Belongs to the amidase family.


ensembl_gene_id: Y56A3A.13.1
symbol: nft-1
gene_biotype: protein_coding
description:
  Nitrilase and fragile histidine triad fusion protein NitFhit; Cleaves A-5'-PPP-5'A to yield AMP and ADP.


ensembl_gene_id: Y56A3A.20.1
symbol: ccf-1
gene_biotype: protein_coding
description:
  CCR4-NOT transcription complex subunit 7; Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression; Belongs to the CAF1 family.


ensembl_gene_id: Y56A3A.27.1
symbol: top-3
gene_biotype: protein_coding
description:
  DNA topoisomerase 3; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)- enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils. Fina [...]


ensembl_gene_id: Y56A3A.29a.1
symbol: ung-1
gene_biotype: protein_coding
description:
  Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.


ensembl_gene_id: Y57A10A.10.1
symbol: tric-1B.1
gene_biotype: protein_coding
description:
  Trimeric intracellular cation channel type 1B.1; Potassium channel that mediates transmembrane potassium transport. Might be required for maintenance of rapid intracellular calcium release (By similarity). May act as a counter-ion channel that functions in synchronization with calcium release from intracellular stores (By similarity). Binds phosphatidylinositol 4,5- bisphosphate (PIP2).


ensembl_gene_id: Y57A10A.16.1
symbol: trpp-5
gene_biotype: protein_coding
description:
  Trafficking protein particle complex subunit 5; May play a role in vesicular transport from endoplasmic reticulum to Golgi; Belongs to the TRAPP small subunits family. BET3 subfamily.


ensembl_gene_id: Y57A10A.20.1
symbol: sinh-1
gene_biotype: protein_coding
description:
  Stress-activated map kinase-interacting protein 1 homolog; May interact with a MAP kinase. May act on Ras-regulated pathways (By similarity).


ensembl_gene_id: Y57A10A.28.1
symbol: tric-1B.2
gene_biotype: protein_coding
description:
  Trimeric intracellular cation channel type 1B.2; Potassium channel that mediates transmembrane potassium transport (By similarity). Might be required for maintenance of rapid intracellular calcium release (By similarity). May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores (By similarity). Binds phosphatidylinositol 4,5-bisphosphate (PIP2).


ensembl_gene_id: Y57A10A.29.1
symbol: Y57A10A.29
gene_biotype: protein_coding
description:
  Succinate dehydrogenase assembly factor 2, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer; Belongs to the SDHAF2 family.


ensembl_gene_id: Y57A10A.30.4
symbol: ife-5
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 4E-5; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. All 5 eIF4E proteins bind monomethyl cap structures. Only ife-1, ife-2 and ife-5 bind trimethyl cap structures which result from trans-splicing. Translation of trimethyl cap structure mRNAs may be regulated by intracellular redox state; disulfide bonds change the width and depth of the cap-binding cavity determining selectivit [...]


ensembl_gene_id: Y57A10C.6.1
symbol: daf-22
gene_biotype: protein_coding
description:
  Non-specific lipid-transfer protein-like 2; Catalyzes the thiolytic cleavage of 3-ketoacyl-CoA with 8-16 carbon residues in the acyl group using a ping-pong mechanism whereby binding to 3-ketooctanoyl-CoA results in the release of acetyl-CoA and the subsequent addition of CoA produces 3-ketohexanohyl-CoA. Involved in the biosynthesis of the dauer pheromone by providing short chains of fatty acid that are attached to the ascarylose sugars of the pheromone. Belongs to the thiolase-like superfamily. Thiolase family.


ensembl_gene_id: Y57E12AL.5.1
symbol: mdt-6
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 6; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Acts to r [...]


ensembl_gene_id: Y57E12AM.1.1
symbol: Y57E12AM.1
gene_biotype: protein_coding
description:
  Transmembrane protein 258; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are requ [...]


ensembl_gene_id: Y57G11C.10b.1
symbol: gdi-1
gene_biotype: protein_coding
description:
  Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family.


ensembl_gene_id: Y57G11C.11a.2
symbol: coq-3
gene_biotype: protein_coding
description:
  Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.


ensembl_gene_id: Y57G11C.13.1
symbol: arl-8
gene_biotype: protein_coding
description:
  Novel small G protein indispensable for equal chromosome segregation; Belongs to the small GTPase superfamily. Arf family.


ensembl_gene_id: Y57G11C.3a.1
symbol: Y57G11C.3
gene_biotype: protein_coding
description:
  Putative 6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.


ensembl_gene_id: Y59A8A.1.1
symbol: csn-1
gene_biotype: protein_coding
description:
  COP9 signalosome complex subunit 1; Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. The CSN complex plays an essential role in embryogenesis and oogenesis and is required to regulate microtubule stability in the early embryo. Mediates mei-3/katanin targeting for degradation at the mei [...]


ensembl_gene_id: Y59A8B.14a.1
symbol: par-4
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase par-4; Required for cytoplasmic partitioning and asymmetric cell division in early embryogenesis. Controls the asymmetric cell division of the Q.p neuroblast lineage. Involved in mediating cell polarization via regulation of anillin family scaffold proteins. Phosphorylates and restricts the asymmetry effectors mex-5 and mex-6 to the anterior cytoplasm of the zygote and maintains these phosphorylations until fertilization. May phosphorylate par-1. Required for strd-1 localization to the cell cortex of early embryos and may be required for strd-1 protein s [...]


ensembl_gene_id: Y59A8B.1a.1
symbol: dpy-21
gene_biotype: protein_coding
description:
  Lysine-specific demethylase 9; Histone demethylase that specifically demethylates dimethylated 'Lys-20' of histone H4 (H4K20me2), thereby modulating the chromosome architecture. Promotes chromatin compaction by converting H4k20me2 to H4K20me1 leading to transcriptional repression. Required for X chromosome dosage compensation by enriching H4K20me1 on X chromosomes and thereby reducing X-linked gene transcription in hermaphrodites throughout development. X chromosome specificity is mediated by the recruitment through proteins of the condensin-like dosage compensation complex (DCC). Requ [...]


ensembl_gene_id: Y59A8B.20.1
symbol: lon-8
gene_biotype: protein_coding
description:
  Protein lon-8; Secreted protein that is involved in larval elongation, early adult growth and male tail development.


ensembl_gene_id: Y59A8B.23a.1
symbol: gck-3
gene_biotype: protein_coding
description:
  Germinal center kinase 3; Plays a role in osmotic stress responses by regulating ion homeostasis and by controlling cell volume via the phosphorylation- mediated inhibition of the chloride channel clh-3. In addition, increases gpdh-1 translation upon osmotic stress, likely downstream of wnk-1. Involved in several developmental processes including the tubular formation of the excretory canals, the formation of the intestine and the progression through larval stages. In addition, required for germ line development by controlling meiosis and chromosomal segregation during spermatogenesis. [...]


ensembl_gene_id: Y59E9AR.3.1
symbol: tbx-30
gene_biotype: protein_coding
description:
  Putative T-box protein 30/42; Involved in the regulatory network to control embryonic patterning and morphogenesis. Implicated in negatively regulating vab-7 expression at the anterior of embryos.


ensembl_gene_id: Y59H11AL.1b.1
symbol: npr-22
gene_biotype: protein_coding
description:
  Neuropeptide receptor 22; Receptor for the LURY-1-1 and LURY-1-2 peptides which control food-related processes including feeding, lifespan, egg-laying and roaming behavior. Receptor for flp-7 which stimulates serotonin-induced fat loss. Serotonin induces secretion of flp-7 from neurons and binding to npr-22 which leads to induction of the atgp-1 lipase and subsequent fat loss. Acts in vitro as a receptor for the flp-7 FMRFamide- like neuropeptides TPMQRSSMVRF-amide, SPMQRSSMVRF-amide, SPMERSAMVRF- amide and SPMDRSKMVRF-amide. Also acts in vitro as a receptor for a number of other FMRFa [...]


ensembl_gene_id: Y59H11AR.2a.1
symbol: catp-7
gene_biotype: protein_coding
description:
  Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.


ensembl_gene_id: Y5H2B.2b.2
symbol: nhr-13
gene_biotype: protein_coding
description:
  Nuclear hormone receptor family member nhr-13; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family.


ensembl_gene_id: Y60A3A.1.1
symbol: unc-51
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase unc-51; Protein kinase important for axonal elongation and axonal guidance. Functions in the CAN axons to direct both anterior and posterior migrations. Phosphorylates both unc-14 and vab-8. Component of the unc-51/atg-13 complex that is probably recruited by lgg-1 to preautophagosomes and is required for autophagosome formation. Interaction with autophagy related proteins such as atg-13 links it to the autophagy machinery to in turn promote P-granule degradation in somatic cells. Plays a role in mitophagy during limited food availability. Regulates cell [...]


ensembl_gene_id: Y60A3A.12.1
symbol: chk-2
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase chk-2; Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Phosphorylates and inhibits cdc25 phosphatase, preventing entry into mitosis. Required for nuclear reorganization and homologous chromosome pairing during meiotic prophase.


ensembl_gene_id: Y62E10A.1.2
symbol: rla-2
gene_biotype: protein_coding
description:
  Ribosomal protein, Large subunit, Acidic (P1); Belongs to the eukaryotic ribosomal protein P1/P2 family.


ensembl_gene_id: Y62E10A.11.1
symbol: mdt-9
gene_biotype: protein_coding
description:
  Putative guanine nucleotide exchange factor MSS4 homolog; Guanine-nucleotide-releasing protein that acts on members of the sec4/ypt1/rab subfamily.


ensembl_gene_id: Y62E10A.12a.1
symbol: lsm-3
gene_biotype: protein_coding
description:
  U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA.


ensembl_gene_id: Y62E10A.24.1
symbol: Y62E10A.24
gene_biotype: protein_coding
description:
  Ribonuclease P protein subunit p20; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.


ensembl_gene_id: Y62F5A.1a.1
symbol: mdt-8
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 8; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).


ensembl_gene_id: Y63D3A.4.1
symbol: tdpt-1
gene_biotype: protein_coding
description:
  5'-tyrosyl-DNA phosphodiesterase; DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead- end complexes between DNA and the topoisomerase 2 (top2) active site tyrosine residue. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals; Belongs to the CCR4/nocturin family. TTRAP/TDP2 subfamily.


ensembl_gene_id: Y63D3A.8.1
symbol: Y63D3A.8
gene_biotype: protein_coding
description:
  TLC domain-containing protein fld-1; Regulates the composition and fluidity of the plasma membrane. Inhibits the incorporation of membrane-fluidizing phospholipids containing omega-3 long-chain polyunsaturated fatty acids (LCPUFA) and thereby promotes membrane rigidity. Does not appear to have any effect on LCPUFA synthesis.


ensembl_gene_id: Y64G10A.6.1
symbol: ilcr-1
gene_biotype: protein_coding
description:
  Interleukin cytokine receptor-related protein 1; Forms a receptor complex together with receptor ilcr-2, which upon activation acts as a modulator of neuronal activity. Binding of the ligand ilc-17.1 to the ilcr-1/2 receptor complex triggers a signaling cascade that activates the downsteam signaling components actl-1, pik-1 and nfki-1, and results in increased neuronal activity in RMG interneurons in response to input from oxygen-sensing neurons. This leads to increased animal movement and promotes aggregation behavior.


ensembl_gene_id: Y65B4BR.5b.1
symbol: icd-2
gene_biotype: protein_coding
description:
  Nascent polypeptide-associated complex subunit alpha; May promote appropriate targeting of ribosome-nascent polypeptide complexes.


ensembl_gene_id: Y66A7A.2a.1
symbol: Y66A7A.2
gene_biotype: protein_coding
description:
  Ribonuclease P/MRP protein subunit POP5; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.


ensembl_gene_id: Y66A7A.6.2
symbol: gly-8
gene_biotype: protein_coding
description:
  Probable N-acetylgalactosaminyltransferase 8; Potential glycopeptide transferase involved in O-linked oligosaccharide biosynthesis (By similarity). In contrast to other members of the family, it does not act as a peptide transferase that transfers GalNAc onto serine or threonine residue on peptides that have been tested. Some peptide transferase activity is however not excluded, considering that its appropriate peptide substrate may remain unidentified.


ensembl_gene_id: Y66D12A.17.1
symbol: such-1
gene_biotype: protein_coding
description:
  Suppressor of spindle checkpoint defect 1; Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (By similarity). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins (By similarity). Required for the metaphase to anaphase transition in meiosis. Plays a role in the segregation of DNA and centrioles during meiosis in male germ cells. Belongs to the APC5 family.


ensembl_gene_id: Y66D12A.20.1
symbol: spe-6
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase spe-6; Serine/threonine-protein kinase which is involved in spermatogenesis. In spermatocytes, regulates meiosis and the localization and assembly of major sperm protein (MSP) into fibrous bodies. In addition, may suppress the initiation of spermiogenesis downstream of spe-8, spe-12, spe-27 and spe-29.


ensembl_gene_id: Y66D12A.22.1
symbol: tin-10
gene_biotype: protein_coding
description:
  Mitochondrial import inner membrane translocase subunit Tim10; Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (Probable).


ensembl_gene_id: Y66D12A.7.1
symbol: Y66D12A.7
gene_biotype: protein_coding
description:
  Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).


ensembl_gene_id: Y66H1A.2a.1
symbol: dpm-1
gene_biotype: protein_coding
description:
  Dolichol-phosphate mannosyltransferase subunit 1; Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.


ensembl_gene_id: Y66H1A.4.2
symbol: Y66H1A.4
gene_biotype: protein_coding
description:
  Probable H/ACA ribonucleoprotein complex subunit 1-like protein; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity).


ensembl_gene_id: Y66H1B.4.1
symbol: spl-1
gene_biotype: protein_coding
description:
  Sphingosine-1-phosphate lyase; Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Essential for normal development, intestinal integrity, growth and reproduction.


ensembl_gene_id: Y67D8A.2b.2
symbol: Y67D8A.2
gene_biotype: protein_coding
description:
  Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I.


ensembl_gene_id: Y67H2A.4d.1
symbol: micu-1
gene_biotype: protein_coding
description:
  Calcium uptake protein 1 homolog, mitochondrial; Key regulator of mitochondrial calcium uniporter (MCU).


ensembl_gene_id: Y67H2A.6b.1
symbol: csn-6
gene_biotype: protein_coding
description:
  COP9 signalosome complex subunit 6; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. The CSN complex plays an essential role in embryogenesis and oogenesis and is required to regulate microtubule stability in the early embryo. Mediates mei-3/katanin targeting for degradation at the meiosis to mi [...]


ensembl_gene_id: Y67H2A.8.1
symbol: fat-1
gene_biotype: protein_coding
description:
  Omega-3 fatty acid desaturase fat-1; Omega-3 fatty acid desaturase that acts on a range of substrates. Catalyzes the desaturation of linolenic acid (18:2n-6), dihomo-gamma-linoleic acid (DHGLA) (20:3n-6), and arachidonic acid (20:4n-6), to generate gamma linolenic acid (18:3n-3), eicosatetraenoic acid (20:4n-3) and eicosapentaenoic acid (20:5n-3) respectively. Although the enzyme has been suggested to act on glycerolipids, the precise nature of the fatty acid substrate is unknown.


ensembl_gene_id: Y69A2AR.2a.1
symbol: ric-8
gene_biotype: protein_coding
description:
  Synembryn; Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins independently of G-protein coupled receptors. Acts by exchanging bound GDP for free GTP. Able to facilitate synaptic transmission in the nervous system probably by activating G(q)-alpha (egl-30). Also able to activate the G(s)-alpha in synaptic signaling network. Plays a key role in asymmetric spindle positioning, a step for asymmetric cell division that generates cell diversity during development by activating G(i)-alpha protein goa-1 and gpa-16 independently of G-protein couple [...]


ensembl_gene_id: Y69A2AR.4.1
symbol: smf-3
gene_biotype: protein_coding
description:
  NRAMP-like transporter smf-3; Probable divalent metal ion transporter which regulates the uptake of several heavy metals such as Mn(2+), Al(3+) and iron. Plays a role in modulating Al(3+)-induced dopamine (DA) neuron degeneration through the intracellular sequestration of Al(3+).


ensembl_gene_id: Y69A2AR.5.1
symbol: daao-1
gene_biotype: protein_coding
description:
  D-amino-acid oxidase; Catalyzes oxidative deamination of D-amino acids, in particular D-alanine, and could be responsible for the degradation of diet-derived D-alanine in the intestine. Acts on a variety of D-amino acids with greater preference towards those with basic and aromatic groups followed by those bearing neutral groups. Has no activity against acidic D-amino acids, L-amino acids or N-methyl-L-aspartic acid. May play a role in egg-laying events and early development.


ensembl_gene_id: Y6D11A.2.1
symbol: arx-4
gene_biotype: protein_coding
description:
  Probable actin-related protein 2/3 complex subunit 2; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament (By similarity).


ensembl_gene_id: Y71A12B.1a.1
symbol: rps-6
gene_biotype: protein_coding
description:
  40S ribosomal protein S6; May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (By similarity). Negatively regulates lifespan ; Belongs to the eukaryotic ribosomal protein eS6 family.


ensembl_gene_id: Y71D11A.3b.1
symbol: acsd-1
gene_biotype: protein_coding
description:
  2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.


ensembl_gene_id: Y71D11A.5.1
symbol: lgc-46
gene_biotype: protein_coding
description:
  Probable ligand-gated ion channel 46; Probable component of a ligand-gated anion channel. Negatively regulates synaptic transmission and synaptic vesicle release in response to acetylcholine in cholinergic motor neurons. Role in synaptic vesicle release kinetics may be in association with the ligand-gated ion channel protein acc-4.


ensembl_gene_id: Y71F9AL.16.1
symbol: arx-1
gene_biotype: protein_coding
description:
  Actin-related protein 3; Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (By similarity).


ensembl_gene_id: Y71F9AL.17.1
symbol: copa-1
gene_biotype: protein_coding
description:
  Coatomer subunit alpha; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.


ensembl_gene_id: Y71F9AL.18a.1
symbol: parp-1
gene_biotype: protein_coding
description:
  Poly [ADP-ribose] polymerase 1; Poly[ADP-ribose] polymerase modifies various nuclear proteins by poly(ADP-ribosyl)ation, a post-translational modification synthesized after DNA damage that appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks and programmed cell death. Involved in protection of the genome against mutations.


ensembl_gene_id: Y71F9AM.5a.1
symbol: nxt-1
gene_biotype: protein_coding
description:
  NTF2-related export protein; Stimulator of protein export for NES-containing proteins. Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA (By similarity).


ensembl_gene_id: Y71F9AR.1.1
symbol: bam-2
gene_biotype: protein_coding
description:
  Neurexin-related protein bam-2; Maintains the normal guidance and termination of axonal branches of VC motorneurons. By associating with cell adhesion protein casy-1, mediates axonal interactions to establish synaptic connections between the male-specific sensory neuron HOA and the AVG interneuron. Plays a role in regulating male mating behavior.


ensembl_gene_id: Y71F9B.10c.1
symbol: sop-3
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 1.1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).


ensembl_gene_id: Y71F9B.2a.1
symbol: Y71F9B.2
gene_biotype: protein_coding
description:
  Phosphatidate cytidylyltransferase, mitochondrial; Catalyzes the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA) in the mitochondrial inner membrane. Required for the biosynthesis of the dimeric phospholipid cardiolipin, which stabilizes supercomplexes of the mitochondrial respiratory chain in the mitochondrial inner membrane.


ensembl_gene_id: Y71F9B.4.1
symbol: snr-7
gene_biotype: protein_coding
description:
  Probable small nuclear ribonucleoprotein G; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family.


ensembl_gene_id: Y71F9B.7.1
symbol: plk-2
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase plk-2; Serine/threonine-protein kinase which plays a role, during oogenesis, in chromosome pairing and synapsis, by facilitating the recruitment and attachment of meiotic chromosomes to the nuclear envelope during prophase. Regulates the formation of sun-1 patches along the nuclear envelope. Promotes meiotic nuclei apoptosis in response to chromosomal asynapsis. Plays a redundant role with plk-1 in the establishment of cell polarity downstream of mex-5 and mex-6 during the first embryonic cell divisions. Plays a role in nicotinic acetylcholine receptor-  [...]


ensembl_gene_id: Y71G12B.12a.1
symbol: atg-5
gene_biotype: protein_coding
description:
  Autophagy-related protein 5; Involved in autophagic vesicle formation (By similarity). Conjugation with lgg-3/ATG12, through a ubiquitin-like conjugating system involving atg-7 as an E1-like activating enzyme and atg-10 as an E2-like conjugating enzyme, is essential for its function (By similarity). Most likely a component of an atg-5-lgg-3-atg-16 complex that promotes autophagosome formation by associating with lgg-2, but not lgg-1, at the preautophagosomal membrane. Probably, as part of an atg-5-lgg-3-atg-16 complex, required for lgg-1 lipidation; the complex acts as an E3-like enzym [...]


ensembl_gene_id: Y71G12B.14.1
symbol: lsm-6
gene_biotype: protein_coding
description:
  Sm domain-containing protein; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family.


ensembl_gene_id: Y71G12B.16.1
symbol: drag-1
gene_biotype: protein_coding
description:
  RGM domain family member drag-1; Probably in association with the cell surface receptor unc-40 positively modulates the BMP-like Sma/Mab signaling pathway through interaction with both the ligand dbl-1 and its type I receptor sma-6. Regulates body size and this may be through modulation of the Sma/Mab signaling pathway ; Belongs to the repulsive guidance molecule (RGM) family.


ensembl_gene_id: Y71G12B.20a.1
symbol: mab-20
gene_biotype: protein_coding
description:
  Semaphorin-2A; Regulates the formation or stabilization of cell-cell contacts at several stages of epithelial morphogenesis. In early embryonic development, required for proper ventral closure of the epidermis. During male tail morphogenesis, regulates precursor cell sorting and allows the formation of distinct sensory rays. Seems to control cell-cell contact formation through 2 parallel pathways, one involving efn-4 and one involving plx-2 and unc-129. Involved in axon guidance. Probably by binding receptor plx-2, regulates fln-1-mediated remodeling of the actin cytoskeleton and thus  [...]


ensembl_gene_id: Y71G12B.24a.1
symbol: mppa-1
gene_biotype: protein_coding
description:
  Mitochondrial-processing peptidase subunit alpha; Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.


ensembl_gene_id: Y71G12B.27.1
symbol: Y71G12B.27
gene_biotype: protein_coding
description:
  Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.


ensembl_gene_id: Y71G12B.4.1
symbol: pghm-1
gene_biotype: protein_coding
description:
  Probable peptidylglycine alpha-hydroxylating monooxygenase 1; Monooxygenase that catalyzes an essential reaction in C- terminal alpha-amidation of peptides. Produces an unstable peptidyl(2- hydroxyglycine) intermediate. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity. Belongs to the copper type II ascorbate-dependent monooxygenase family.


ensembl_gene_id: Y71H10A.1a.1
symbol: pfk-1.1
gene_biotype: protein_coding
description:
  ATP-dependent 6-phosphofructokinase 1; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.


ensembl_gene_id: Y71H2AM.1.1
symbol: Y71H2AM.1
gene_biotype: protein_coding
description:
  Probable tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.


ensembl_gene_id: Y71H2AM.19b.1
symbol: laf-1
gene_biotype: protein_coding
description:
  ATP-dependent RNA helicase laf-1; Multifunctional ATP-dependent RNA helicase. Plays a role in RNA remodeling, but is not required for RNA unwinding. Binds to RNA in a concentration-dependent manner to stimulate annealing between two complementary strands of RNA. This process is also dependent upon ATP; ATP reduces binding to RNA and subsequently diminishes RNA annealing. Involved in many cellular processes, which do not necessarily require its ATPase/helicase catalytic activities. Involved in the regulation of transcription and translation initiation. Involved in innate immunity (By si [...]


ensembl_gene_id: Y71H2AM.20a.1
symbol: Y71H2AM.20
gene_biotype: protein_coding
description:
  Serine/threonine-protein phosphatase 2A activator; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.


ensembl_gene_id: Y71H2B.3.1
symbol: ppfr-4
gene_biotype: protein_coding
description:
  Serine/threonine-protein phosphatase 4 regulatory subunit ppfr-4; Probable regulatory subunit of serine/threonine-protein phosphatase PP4 which may play a role in meiosis and embryonic mitosis. Probably in association with catalytic subunit pph-4.1, regulates microtubule severing during oocyte meiosis II by dephosphorylating and likely activating mei-1, a component of the katanin microtubule severing complex.


ensembl_gene_id: Y71H2B.6.1
symbol: mdt-19
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 19; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).


ensembl_gene_id: Y73B6A.5b.1
symbol: lin-45
gene_biotype: protein_coding
description:
  Raf homolog serine/threonine-protein kinase; Protein kinase that participates in the induction of vulva and has roles in fertility and viability. Acts downstream of the Ras protein let-60. Required for progression of developing oocytes through the pachytene stage. Plays a role in responses to M.nematophilum- mediated bacterial infection by promoting tail swelling and preventing constipation. Positively regulates lifespan upstream of mek-2 and mpk-1. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.


ensembl_gene_id: Y73B6BL.30a.1
symbol: blos-2
gene_biotype: protein_coding
description:
  Biogenesis of lysosome-related organelles complex 1 subunit 2; Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in gut granule biogenesis. Belongs to the BLOC1S2 family.


ensembl_gene_id: Y73B6BL.32.1
symbol: lsm-8
gene_biotype: protein_coding
description:
  U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.


ensembl_gene_id: Y73B6BL.7a.1
symbol: csp-2
gene_biotype: protein_coding
description:
  Putative inactive caspase B subunit p17; [Isoform b]: Putative inactive caspase. In the germline, binds caspase ced-3 zymogen and prevents ced-3 autoactivation. Does not affect the caspase activity of mature ced-3 and ced-4-mediated mature ced-3 activation. Negatively regulates germline apoptosis by inhibiting autocleavage of caspase ced-3. Involved in fertility ; Belongs to the peptidase C14A family.


ensembl_gene_id: Y73B6BL.9a.1
symbol: hil-2
gene_biotype: protein_coding
description:
  Histone H1.2; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures.


ensembl_gene_id: Y73C8B.4.1
symbol: lag-2
gene_biotype: protein_coding
description:
  Protein lag-2; Putative intercellular signal for lin-12 and GLP-1 receptors. Functions in uterine cells to promote basement membrane mobility during tissue remodeling.


ensembl_gene_id: Y73E7A.4.1
symbol: cpx-1
gene_biotype: protein_coding
description:
  Putative complexin-1; Positively regulates a late step in synaptic vesicle exocytosis; Belongs to the complexin/synaphin family.


ensembl_gene_id: Y73E7A.7a.1
symbol: bre-4
gene_biotype: protein_coding
description:
  Beta-1,4-N-acetylgalactosaminyltransferase bre-4; Catalyzes the transfer of galactose onto proteins or lipids. Required for susceptibility to pore-forming crystal toxins in conjunction with bre-1, bre-2, bre-3 and bre-5. Belongs to the glycosyltransferase 7 family.


ensembl_gene_id: Y73F8A.1.1
symbol: pkd-2
gene_biotype: protein_coding
description:
  Polycystin-2; Functions as a calcium permeable cation channel. Required for 2 aspects of male mating behavior: response to hermaphrodite contact and vulva location. Acts in the same pathway as lov-1 and atp-2 in response behavior.


ensembl_gene_id: Y73F8A.21c.1
symbol: nhr-5
gene_biotype: protein_coding
description:
  Nuclear hormone receptor family member nhr-5; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family.


ensembl_gene_id: Y73F8A.24c.1
symbol: Y73F8A.24
gene_biotype: protein_coding
description:
  General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family.


ensembl_gene_id: Y74C10AR.1a.1
symbol: eif-3.I
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 3 subunit I; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.


ensembl_gene_id: Y74C9A.2a.1
symbol: nlp-40
gene_biotype: protein_coding
description:
  Neuropeptide-like peptides nlp-40; [Peptide P3]: Neuropeptide ligand for the G-protein coupled receptor aex-2. Activates and regulates the rhythmic calcium influx in DVB GABergic neurons during the defecation motor program, which is a coordinated series of three muscle contractions that occurs every 45 seconds.


ensembl_gene_id: Y74C9A.3.1
symbol: homt-1
gene_biotype: protein_coding
description:
  Alpha N-terminal protein methyltransferase 1; Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif.


ensembl_gene_id: Y75B12B.2.2
symbol: cyn-7
gene_biotype: protein_coding
description:
  Peptidyl-prolyl cis-trans isomerase 7; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.


ensembl_gene_id: Y75B12B.5.1
symbol: cyn-3
gene_biotype: protein_coding
description:
  Peptidyl-prolyl cis-trans isomerase 3; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.


ensembl_gene_id: Y75B8A.11a.1
symbol: lury-1
gene_biotype: protein_coding
description:
  Luqin-like RYamide peptides lury-1; [LURY-1-1]: Acts as a ligand for the npr-22 receptor and controls food-related processes including feeding, lifespan, egg-laying and roaming behavior. Secreted in the presence of food, leading to reduced feeding and roaming behavior and increased egg laying and lifespan. Activity may be latent under normal conditions but induced under conditions that cause hyperactivation of the pharynx such as abrupt refeeding after starvation.


ensembl_gene_id: Y75B8A.12.1
symbol: osm-12
gene_biotype: protein_coding
description:
  Bardet-Biedl syndrome 7 protein homolog; Component of the BBSome complex (By similarity). The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia (By similarity). The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function (By similarity). Required for proper BBSome complex assembly and its ciliary localization (By similarity). Required for cilia biogenesis and both the assembly and movement of intraflagellar transport proteins along the ciliary axoneme. Plays a role in  [...]


ensembl_gene_id: Y75B8A.14.1
symbol: Y75B8A.14
gene_biotype: protein_coding
description:
  GPN-loop GTPase 3; Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.


ensembl_gene_id: Y75B8A.22.1
symbol: tim-1
gene_biotype: protein_coding
description:
  Protein timeless homolog; Plays an important role in chromosome cohesion during both mitosis and meiosis. In prophase of meiosis, it is involved in the formation of the synaptonemal complex (SC) and specifically, in the diplotene and diakinesis phases of prophase, it stabilizes the association of homologous chromosomes during synapsis and sister chromatid cohesion. It regulates cohesin subunits to promote meiotic chromosome cohesion and localizes non-SMC (structural maintenance of chromosome) cohesin subunits to chromatin prior to or during pre-meiotic S phase. Implicated in influencin [...]


ensembl_gene_id: Y75B8A.30.1
symbol: pph-4.1
gene_biotype: protein_coding
description:
  Serine/threonine-protein phosphatase 4 catalytic subunit 1; Protein phosphatase which plays an essential role in meiosis and in early embryonic mitosis. During spermatocyte meiosis and the first embryonic mitosis, regulates centrosome maturation, and thus spindle formation, by recruiting some of the components of the pericentriolar material (PCM). During oocyte meiosis I, regulates meiotic chromosome dynamics including synapsis-independent chromosome pairing, restriction of synapsis to homologous chromosomes, programmed DNA double-strand break initiation and crossover formation resulti [...]


ensembl_gene_id: Y75B8A.4.1
symbol: lonp-2
gene_biotype: protein_coding
description:
  Lon protease homolog 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import.


ensembl_gene_id: Y75B8A.7.1
symbol: Y75B8A.7
gene_biotype: protein_coding
description:
  U3 small nucleolar ribonucleoprotein protein MPP10; Involved in nucleolar processing of pre-18S ribosomal RNA. Belongs to the MPP10 family.


ensembl_gene_id: Y75B8A.9a.1
symbol: gly-11
gene_biotype: protein_coding
description:
  Putative polypeptide N-acetylgalactosaminyltransferase 11; May catalyze the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor.


ensembl_gene_id: Y76B12C.7a.1
symbol: cpsf-1
gene_biotype: protein_coding
description:
  Probable cleavage and polyadenylation specificity factor subunit 1; CPSF plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A)polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction (By similarity).


ensembl_gene_id: Y77E11A.13a.1
symbol: npp-20
gene_biotype: protein_coding
description:
  Protein SEC13 homolog; Functions as a component of the nuclear pore complex (NPC) and the COPII coat (By similarity). Required for the nuclear import of hcp-4 during mitotic prophase, this step is essential for centrosome assembly and resolution. Belongs to the WD repeat SEC13 family.


ensembl_gene_id: Y79H2A.11a.1
symbol: zyg-8
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase zyg-8; Plays a role in spindle positioning during asymmetric division of one-cell stage embryos. Affects spindle position by promoting microtubule assembly during anaphase.


ensembl_gene_id: Y80D3A.1.1
symbol: wars-1
gene_biotype: protein_coding
description:
  Tryptophanyl(W) Amino-acyl tRNA Synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family.


ensembl_gene_id: Y81G3A.3b.1
symbol: gcn-2
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 2-alpha kinase gcn-2; Serine/threonine-protein kinase which phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (eIF2alpha), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis (By similarity). Involved in the unfolded protein response (UPR) triggered by several stresses including mitochondrial, osmotic and oxidative stresses, amino acid deprivation and UV irradiation, probably by phosphorylating and inhibiting eIF2alpha. In addition, leads to [...]


ensembl_gene_id: Y82E9BR.3.2
symbol: Y82E9BR.3
gene_biotype: protein_coding
description:
  ATP synthase lipid-binding protein, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism  [...]


ensembl_gene_id: Y87G2A.10a.1
symbol: vps-28
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex, a regulator of vesicular trafficking process; Belongs to the VPS28 family.


ensembl_gene_id: Y87G2A.11.1
symbol: eipr-1
gene_biotype: protein_coding
description:
  EARP-interacting protein 1; Plays a role in the trafficking of cargo to dense-core vesicles, probably through association with the endosome-associated recycling protein (EARP) complex. Important for neuronal function. Belongs to the WD repeat EIPR1 family.


ensembl_gene_id: Y87G2A.14.1
symbol: ndx-8
gene_biotype: protein_coding
description:
  Peroxisomal coenzyme A diphosphatase ndx-8; Coenzyme A diphosphatase which mediates the cleavage of CoA into 3',5'-ADP and 4'-phosphopantetheine; Belongs to the Nudix hydrolase family.


ensembl_gene_id: Y87G2A.17.1
symbol: soem-1
gene_biotype: protein_coding
description:
  Protein soem-1; Functions downstream of migratory protein mig-13 and may play a role in the control of Q neuroblast migration during larval development.


ensembl_gene_id: Y87G2A.3b.1
symbol: atg-4.1
gene_biotype: protein_coding
description:
  Cysteine protease atg-4.1; Cysteine protease required for autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins lgg-1, to reveal a C-terminal glycine (Probable). Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy (Probable). Its cleavage activity is functionally redundant to atg-4.2, but it cleaves lgg-1 precursors more efficiently than atg-4.2 (Probable). Acts redundantly with atg-4.2 to promote the lgg-1 delipidation to release the protein fro [...]


ensembl_gene_id: Y92C3B.2a.1
symbol: uaf-1
gene_biotype: protein_coding
description:
  Splicing factor U2AF 65 kDa subunit; Necessary for the splicing of pre-mRNA. Binds to the polypyrimidine tract of introns early during spliceosome assembly (By similarity).


ensembl_gene_id: Y92C3B.3b.2
symbol: rab-18
gene_biotype: protein_coding
description:
  Ras-related protein Rab-18; Plays a role in apical endocytosis/recycling. May be implicated in transport between the plasma membrane and early endosomes (By similarity). Plays a role in the shedding of pathogen spores from intestinal cells.


ensembl_gene_id: Y92H12A.1b.2
symbol: src-1
gene_biotype: protein_coding
description:
  Tyrosine protein-kinase src-1; Non-receptor tyrosine-protein kinase which plays a role in endoderm development by controlling spindle orientation in EMS blastomere, probably downstream of receptor mes-1. Also involved in embryonic body morphogenesis, especially in the formation of the pharynx and the intestine. May be dispensable for pharyngeal muscle organization in the adult. Probably phosphorylates netrin receptor unc-5, to regulate distal tip cell (DTC) migration during gonad development and in axon repulsion. Plays a role in the migration of the QR neuroblast, a precursor of the A [...]


ensembl_gene_id: Y92H12BL.1a.2
symbol: Y92H12BL.1
gene_biotype: protein_coding
description:
  Threonylcarbamoyladenosine tRNA methylthiotransferase; Catalyzes the methylthiolation of N6- threonylcarbamoyladenosine (t(6)A), leading to the formation of 2- methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine. Belongs to the methylthiotransferase family. CDKAL1 subfamily.


ensembl_gene_id: Y94H6A.8.2
symbol: Y94H6A.8
gene_biotype: protein_coding
description:
  Probable NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).


ensembl_gene_id: Y94H6A.9a.1
symbol: ubxn-2
gene_biotype: protein_coding
description:
  UBX domain-containing protein 2; Ubiquitin-binding protein which acts as an adapter for ATPase cdc-48.1 and/or cdc-48.2, conferring substrate specificity. Together with ubxn-2 and ubxn-3, plays a role in hermaphrodite spermatogenesis probably by promoting the degradation of sex determination terminal factor tra-1. Probably in association with ATPase cdc-48.1 or/and cdc-48.2, regulates the centrosomal levels of kinase air-1 levels during mitotic progression by promoting air-1 removal from centrosomes in prophase. Also, regulates spindle orientation in the one-cell embryo by controlling  [...]


ensembl_gene_id: Y95B8A.10a.1
symbol: pde-6
gene_biotype: protein_coding
description:
  Probable 3',5'-cyclic phosphodiesterase pde-6; Belongs to the cyclic nucleotide phosphodiesterase family.


ensembl_gene_id: Y95B8A.5a.1
symbol: gpa-16
gene_biotype: protein_coding
description:
  Guanine nucleotide-binding protein alpha-16 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. In the 1-cell embryo, probably together with goa-1, controls nuclear rotation and spindle elongation during mitosis. During the first embryonic cell divisons, plays a role in gpr-1/2 cortical localization and in the proper orientation of EMS blastomere mitotic spindle. Belongs to the G-alpha family.


ensembl_gene_id: Y97E10AR.5.1
symbol: rpb-9
gene_biotype: protein_coding
description:
  TFIIS-type domain-containing protein; Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.


ensembl_gene_id: Y97E10AR.7.2
symbol: lmtr-2
gene_biotype: protein_coding
description:
  Ragulator complex protein LAMTOR2 homolog; Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. May activate the TOR signaling cascade in response to amino acids; Belongs to the GAMAD family.


ensembl_gene_id: ZC101.2e.1
symbol: unc-52
gene_biotype: protein_coding
description:
  Basement membrane proteoglycan; Component of an integrin containing attachment complex, which is required for muscle development and maintenance. Probable structural role in myofilament assembly and/or attachment of the myofilament lattice to the cell membrane. May be an extracellular anchor for integrin receptors in body wall muscles and myoepithelial sheath cells. During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles, probably downstream of the integrin complex formed by pat-2 and pat-3. Involved in ovulation.


ensembl_gene_id: ZC116.2.1
symbol: cyc-2.2
gene_biotype: protein_coding
description:
  Probable cytochrome c 2.2; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity).


ensembl_gene_id: ZC116.3.1
symbol: ZC116.3
gene_biotype: protein_coding
description:
  Cubilin homolog; Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake.


ensembl_gene_id: ZC13.4.1
symbol: mab-7
gene_biotype: protein_coding
description:
  Protein male abnormal 7; Plays an important role in determining body shape and sensory ray morphology, possibly by acting as a signaling molecule outside the expressing cell.


ensembl_gene_id: ZC155.3.1
symbol: morc-1
gene_biotype: protein_coding
description:
  Protein morc-1; Involved in gene silencing. Plays a role in germline RNA interference (RNAi), and in particular, the silencing of endogenous small interfering RNA (endo-siRNA) target genes. May play a role in heterochromatin localization and condensation, and the siRNAi-directed trimethylation of 'Lys-9' of histone H3 in hermaphrodite X chromosomes. Promotes transgenerational epigenetic inheritance and germline immortality.


ensembl_gene_id: ZC168.4.3
symbol: cyb-1
gene_biotype: protein_coding
description:
  G2/mitotic-specific cyclin-B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition; Belongs to the cyclin family. Cyclin AB subfamily.


ensembl_gene_id: ZC21.2b.1
symbol: trp-1
gene_biotype: protein_coding
description:
  Transient-receptor-potential-like protein; Could mediate calcium entry and form a calcium permeant channel; Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily.


ensembl_gene_id: ZC239.7.1
symbol: gcy-15
gene_biotype: protein_coding
description:
  Receptor-type guanylate cyclase gcy-15; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity).


ensembl_gene_id: ZC247.3.1
symbol: lin-11
gene_biotype: protein_coding
description:
  Protein lin-11; Probable transcription factor which is required for asymmetric division of vulval blast cells. Involved in olfactory plasticity probably by regulating the expression of transcription factor mbr-1 in RIF neurons. Plays a role in the chemorepulsive response toward ascaroside pheromones mediated by the ADL sensory neurons, probably by regulating E-box motif 5'-CANNTG-3' containing target genes in the ADL neurons. Plays a role in the differentiation of the ADL sensory neurons.


ensembl_gene_id: ZC302.1.2
symbol: mre-11
gene_biotype: protein_coding
description:
  Double-strand break repair protein mre-11; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. In response to ionizing radiation, probably required for the association between the brc-1-brd-1 heterodimer and rad-51 and let-70 in order to activate E3-ubiquitin ligase activity of the heterodimer and induce ubiquitination at DNA damage sites. Belongs to the MRE11/RAD32 family.


ensembl_gene_id: ZC302.2a.1
symbol: wdr-5.3
gene_biotype: protein_coding
description:
  WD repeat-containing protein wdr-5.3; Not required for methylation of histone H3 'Lys-4'. Belongs to the WD repeat WDR5/wds family.


ensembl_gene_id: ZC308.1a.1
symbol: gld-2
gene_biotype: protein_coding
description:
  Poly(A) RNA polymerase gld-2; Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. Acts as a regulator of mitosis/meiosis required for progression through meiotic prophase during oogenesis and spermatogenesis and for promotion of the entry into meiosis from the mitotic cell cycle. May act by regulating and activating gld-1 mRNA activity in germline.


ensembl_gene_id: ZC317.3.1
symbol: glc-3
gene_biotype: protein_coding
description:
  Glutamate-gated chloride channel subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family.


ensembl_gene_id: ZC373.5.1
symbol: ZC373.5
gene_biotype: protein_coding
description:
  Probable methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).


ensembl_gene_id: ZC376.5.1
symbol: trm-1
gene_biotype: protein_coding
description:
  tRNA (guanine(26)-N(2))-dimethyltransferase; Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.


ensembl_gene_id: ZC376.7a.2
symbol: atfs-1
gene_biotype: protein_coding
description:
  Stress activated transcription factor atfs-1; Acts as a transcription factor during mitochondrial stress by activating the mitochondrial unfolded protein response (mtUPR). Induces nuclear and mitochondrial gene transcription, including genes coding for mitochondrial chaperones and proteins involved in glycolysis, amino acid catabolism and innate immunity. Following mitochondrial stress, restores mitochondrial respiratory capacity by limiting the transcription of oxidative phosphorylation (OXPHOS) machinery genes and by promoting the assembly of OXPHOS complexes via the up-regulation of [...]


ensembl_gene_id: ZC395.10.2
symbol: daf-41
gene_biotype: protein_coding
description:
  Co-chaperone protein daf-41; Co-chaperone for hsp90/daf-21. Involved in regulation of longevity, larval entry and exit from the dauer stage of development and response to environmental cues, such as oxidative stress, in a temperature-dependent manner. Role in daf-16 and hsf-1 inhibition at elevated temperatures. Belongs to the p23/wos2 family.


ensembl_gene_id: ZC395.2.1
symbol: clk-1
gene_biotype: protein_coding
description:
  5-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone- independent manner; Belongs to the COQ7 family.


ensembl_gene_id: ZC395.7.1
symbol: hap-1
gene_biotype: protein_coding
description:
  Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.


ensembl_gene_id: ZC404.3a.2
symbol: spe-39
gene_biotype: protein_coding
description:
  Spermatogenesis-defective protein 39; Proposed to be involved in endosomal maturation implicating in part vps-33.2. May play a role in epithelial polarization through stabilization of apical membrane protein content. May play a role in transcriptional regulation (By similarity). Plays a role in lysosomal trafficking, probably via association with the core HOPS complex in a discrete population of endosomes. Essential for vesicular trafficking during spermatogenesis; required during spermiogenesis or sperm activation for the morphogenesis of specialized Golgi-derived fibrous body-membran [...]


ensembl_gene_id: ZC404.9.1
symbol: gck-2
gene_biotype: protein_coding
description:
  Mitogen-activated protein kinase kinase kinase kinase 3; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.


ensembl_gene_id: ZC410.2.1
symbol: mppb-1
gene_biotype: protein_coding
description:
  Mitochondrial-processing peptidase subunit beta; Catalytic subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins (Probable). Preferentially, cleaves after an arginine at position P2 (Probable).


ensembl_gene_id: ZC410.7.1
symbol: lpl-1
gene_biotype: protein_coding
description:
  Putative lipoyltransferase 2, mitochondrial; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. Belongs to the LipB family.


ensembl_gene_id: ZC412.2.1
symbol: gcy-14
gene_biotype: protein_coding
description:
  Receptor-type guanylate cyclase gcy-14; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Regulates chemotaxis responses toward Na(1+) and Li(1+) salt ions and alkaline pH in ASE left (ASEL) sensory neuron. Directly senses environmental alkalinity in ASEL neuron which probably leads to the activation of cGMP-gated cation channel tax2/tax4.


ensembl_gene_id: ZC416.8a.1
symbol: unc-17
gene_biotype: protein_coding
description:
  Vesicular acetylcholine transporter unc-17; Involved in acetylcholine transport into synaptic vesicles. Belongs to the major facilitator superfamily. Vesicular transporter family.


ensembl_gene_id: ZC416.8b.1
symbol: cha-1
gene_biotype: protein_coding
description:
  Choline O-acetyltransferase; Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses (By similarity). Required in SIA sublateral cholinergic motor neurons for a left-right turning behavior that occurs during the lethargus phase of the normal sleep process called 'flipping'. During 'flipping' animals rotate 180 degrees about their longitudinal axis ; Belongs to the carnitine/choline acetyltransferase family.


ensembl_gene_id: ZC434.6b.1
symbol: aph-2
gene_biotype: protein_coding
description:
  Nicastrin; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch (glp-1 or lin-12). It may represents a stabilizing cofactor required for the assembly of the gamma-secretase complex.


ensembl_gene_id: ZC477.9d.1
symbol: deb-1
gene_biotype: protein_coding
description:
  Vinculin; Involved in cell adhesion. May be involved in the attachment of the actin-based microfilaments to the plasma membrane. Involved in ovulation.


ensembl_gene_id: ZC482.1.1
symbol: gab-1
gene_biotype: protein_coding
description:
  Gamma-aminobutyric acid receptor subunit beta; GABA, an inhibitory neurotransmitter, mediates neuronal inhibition by binding to the GABA receptor and opening an integral chloride channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily.


ensembl_gene_id: ZC504.3.1
symbol: cdk-11.2
gene_biotype: protein_coding
description:
  Cyclin-dependent kinase 11.2; Probable cyclin-dependent kinase whose activity is most likely regulated by the cyclin cyl-1/Cylin-L. Acts partially redundantly with cdk-11.1 to ensure embryonic viability. In contrast to cdk-11.1, not essential for male and female fertility.


ensembl_gene_id: ZC504.4c.1
symbol: mig-15
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase mig-15; Involved in cell migration and signal transduction. Important in several developmental processes including epidermal development, Q neuroblast migrations and muscle arm targeting. Required with ina-1/pat-3 to stabilize the commissural axons growth cone along a precise direction and are required for the cell to respond appropriately when signaling in the growth cone must change. During gonad morphogenesis, involved in distal tip cell (DTC) migration from the dorsal side of the hermaphrodite body to the midbody to allow for formation of gonad arms.


ensembl_gene_id: ZC504.5.1
symbol: gur-3
gene_biotype: protein_coding
description:
  Gustatory receptor family protein 3; Chemoreceptor involved in light-induced avoidance behavior. Probably acts as a molecular sensor in I2 pharyngeal neurons, required for the inhibition of feeding in response to light and hydrogen peroxide. Involved in circadian rhythms, probably by acting as a light sensor. In contrast to lite-1, does not act as a photoreceptor.


ensembl_gene_id: ZC506.4c.1
symbol: mgl-1
gene_biotype: protein_coding
description:
  Probable metabotropic glutamate receptor mgl-1; G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors (By similarity).


ensembl_gene_id: ZC513.5.1
symbol: ZC513.5
gene_biotype: protein_coding
description:
  Probable Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase; Adds the eighth mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor (dolichol-PP-Man(7)GlcNAc(2)) required for protein glycosylation; Belongs to the glycosyltransferase 22 family.


ensembl_gene_id: ZC513.6.1
symbol: oma-2
gene_biotype: protein_coding
description:
  CCCH-type zinc finger protein oma-2; Zinc-finger RNA-binding protein that binds to 5'-UA[AU]-3' motifs in the 3'-UTR of maternal mRNAs to suppress translation in oocytes and embryos. Acts redundantly with oma-1 to control the temporal expression and distribution of maternal proteins and thereby promote meiotic progression, oocyte maturation, fertilization and embryonic development. Also, together with oma-1, is involved in P-granule distribution during embryonic development.


ensembl_gene_id: ZC581.1.1
symbol: nekl-2
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase nekl-2; Probable serine/threonine-protein kinase required for the completion of molting. May play a role in endocytosis in the hypodermis syncytium.


ensembl_gene_id: ZC64.3a.1
symbol: ceh-18
gene_biotype: protein_coding
description:
  Homeobox protein ceh-18; Directs gonadal sheath cell differentiation and function. Also directs gonad migration and plays a role in specifying the differentiated phenotypes of epidermal cells during postembryonic development. Plays a role in oogenesis, regulating a sheath cell signal that causes oocytes to maintain diakinesis arrest during meiosis. Negatively regulates oocyte maturation, ovulation and MAPK activation in oocytes when sperm are not available for fertilization. May be recruited by akir-1 to the promoter regions of antimicrobial peptide genes to control gene expression in  [...]


ensembl_gene_id: ZC84.2.1
symbol: tax-4
gene_biotype: protein_coding
description:
  Cyclic nucleotide-gated cation channel; Required for normal thermosensation and chemosensation sensory behavior. Required, downstream of receptor- type guanylate cyclase gcy-9, for CO2-mediated responses in BAG neurons. Required, downstream of receptor-type guanylate cyclase gcy-14, for alkaline pH-mediated responses in ASE-left (ASEL) neurons. Involved in the development of ASJ sensory neuron axon during late larval stages and in the maintenance of normal axon morphology in the adult. Regulates dauer formation. Required for the calcium flux to the cytoplasm in the ASJ sensory neurons  [...]


ensembl_gene_id: ZC84.3.2
symbol: cls-3
gene_biotype: protein_coding
description:
  Protein CLASP-3; Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules; Belongs to the CLASP family.


ensembl_gene_id: ZC84.4.1
symbol: npr-29
gene_biotype: protein_coding
description:
  Probable G-protein coupled receptor npr-29; Not known. Putative receptor; Belongs to the G-protein coupled receptor 1 family.


ensembl_gene_id: ZK1005.1a.1
symbol: tank-1
gene_biotype: protein_coding
description:
  Poly [ADP-ribose] polymerase tankyrase; Poly[ADP-ribose] polymerases modify various nuclear proteins by poly(ADP-ribosyl)ation, a post-translational modification synthesized after DNA damage that appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks and programmed cell death.


ensembl_gene_id: ZK1010.1.1
symbol: ubq-2
gene_biotype: protein_coding
description:
  Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is invol [...]


ensembl_gene_id: ZK1010.3.1
symbol: frg-1
gene_biotype: protein_coding
description:
  Protein FRG1 homolog; Binds to mRNA in a sequence-independent manner. May play a role in regulation of pre-mRNA splicing or in the assembly of rRNA into ribosomal subunits. May be involved in mRNA transport. May be involved in epigenetic regulation of muscle differentiation through regulation of activity of the histone-lysine N-methyltransferase KMT5B (By similarity); Belongs to the FRG1 family.


ensembl_gene_id: ZK1058.1.1
symbol: mmcm-1
gene_biotype: protein_coding
description:
  Probable methylmalonyl-CoA mutase, mitochondrial; Involved, in man, in the degradation of several amino acids, odd-chain fatty acids and cholesterol via propionyl-CoA to the tricarboxylic acid cycle. MCM has different functions in other species (By similarity).


ensembl_gene_id: ZK1058.2.1
symbol: pat-3
gene_biotype: protein_coding
description:
  Integrin beta pat-3; Integrin alpha ina-1/beta pat-3 is a receptor for laminin. Integrin alpha pat-2/beta pat-3 recognizes the sequence R-G-D in its ligands (Probable). Plays a role in cell migration, morphogenesis and probably in cell-cell interactions. During gonad morphogenesis, involved in distal tip cell (DTC)-mediated guidance of gonad elongation, in maintaining their sharp tapering morphology and in their migration. Component of an integrin containing attachment complex, which is required for muscle development and maintenance. Involved in the assembly of dense bodies and M line [...]


ensembl_gene_id: ZK1058.3.1
symbol: ZK1058.3
gene_biotype: protein_coding
description:
  Probable galactose-1-phosphate uridylyltransferase; Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.


ensembl_gene_id: ZK1067.1d.1
symbol: let-23
gene_biotype: protein_coding
description:
  Receptor tyrosine-protein kinase let-23; Tyrosine-protein kinase receptor which, upon binding ligand lin-3, activates 2 signaling cascades: the let-60/Ras and MAP kinase signaling pathway and the let-60-independent phospholipase C-mediated Ca(2+) signaling pathway. Each pathway regulates distinct functions. By activating let-60/Ras, regulates larval development, induction of vulva cell precursors during vulva development, male spicule formation and posterior development of the epidermis. Probably by activating phospholipase plc-3 and inositol 1,4,5-trisphosphate receptor itr-1 signalin [...]


ensembl_gene_id: ZK1067.2b.1
symbol: ZK1067.2
gene_biotype: protein_coding
description:
  NFX1-type zinc finger-containing protein 1 homolog; Epigenetic inheritance factor which, in association with the Argonaute protein wago-4, mediates small RNA-directed transgenerational epigenetic inheritance and thus balances the transgenerational inheritance of epigenetic information. Specifically, maintains a balanced production of small RNAs by preventing the spread of epigenetic signals towards the 5'-end of target mRNAs. Plays a role in small RNA- induced gene silencing in the germline.


ensembl_gene_id: ZK1067.6a.1
symbol: sym-2
gene_biotype: protein_coding
description:
  RNA-binding protein sym-2; mRNA splicing factor that regulates alternative splicing of many genes in embryo. Probably plays a role in the formation of embryo- specific isoforms; Belongs to the ESRP family.


ensembl_gene_id: ZK1098.10e.1
symbol: unc-16
gene_biotype: protein_coding
description:
  JNK-interacting protein; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of synaptic vesicle transport, through interactions with the JNK-signaling components and motor proteins. Binds specific components of the JNK signaling pathway namely jnk-1, jkk-1 and sek-1. Associates with components of the motor protein, kinesin-1. Pre-assembled unc-16 scaffolding complexes are then transported as a cargo of kinesin, to the [...]


ensembl_gene_id: ZK1098.4.1
symbol: eif-2Balpha
gene_biotype: protein_coding
description:
  Probable translation initiation factor eIF-2B subunit alpha; Catalyzes the exchange of eukaryotic initiation factor 2- bound GDP for GTP.


ensembl_gene_id: ZK1098.5.1
symbol: trpp-3
gene_biotype: protein_coding
description:
  Trafficking protein particle complex subunit 3 homolog; May play a role in vesicular transport from endoplasmic reticulum to Golgi (By similarity). Required for the systemic spread of the RNAi response ; Belongs to the TRAPP small subunits family. BET3 subfamily.


ensembl_gene_id: ZK1098.7.2
symbol: mrps-23
gene_biotype: protein_coding
description:
  Probable 28S ribosomal protein S23, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mS23 family.


ensembl_gene_id: ZK1098.8.1
symbol: mut-7
gene_biotype: protein_coding
description:
  Exonuclease mut-7; Represses the transposition of Tc1, Tc3, Tc4, and Tc5, perhaps by degrading transposon-specific messages. Also affects sperm development, sensitivity to RNAi of mainly germline expressed genes, silencing of some germline transgenes, X chromosome loss, and is required for cosuppression (functional silencing of chromosomal loci induced by transgenes) and for silencing induced by antisense RNA oligomers.


ensembl_gene_id: ZK112.2b.1
symbol: ncl-1
gene_biotype: protein_coding
description:
  B-box type zinc finger protein ncl-1; Translational repressor that inhibits protein synthesis. Represses the translation of mRNAs such as fib-1, probably by being recruited by RNA-binding protein nos-2 and the Pumilio proteins puf-5, puf-8 and puf-9 to the consensus core PUF binding motif in the 3'-UTR of fib-1 mRNA. Negatively regulates ribosomal RNA (rRNA) synthesis, ribosomal protein synthesis and nucleolus size. Its role in the negative regulation of nucleolus size is most likely through its negative regulation of the translation of proteins such as the rRNA 2'- O-methyltransferase [...]


ensembl_gene_id: ZK112.7.1
symbol: cdh-3
gene_biotype: protein_coding
description:
  Cadherin-3; Cell adhesion protein involved in the control of epithelial morphogenesis. Together with metalloproteinase zmp-1 and hemicentin him-4, plays a role in anchor cell (AC) invasion during postembryonic vulval development.


ensembl_gene_id: ZK1127.11.1
symbol: him-14
gene_biotype: protein_coding
description:
  MutS protein homolog him-14; Required during the pachytene stage of meiotic prophase for the formation of crossovers between homologous chromosomes. Not needed for pairing or synapsis. May promote crossing over by interfering with Holliday junction branch migration. Has no apparent role in DNA mismatch repair.


ensembl_gene_id: ZK1127.5.1
symbol: ZK1127.5
gene_biotype: protein_coding
description:
  Probable RNA 3'-terminal phosphate cyclase-like protein; Does not have cyclase activity. Plays a role in 40S- ribosomal-subunit biogenesis in the early pre-rRNA processing steps at sites A0, A1 and A2 that are required for proper maturation of the 18S RNA (By similarity); Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.


ensembl_gene_id: ZK1127.7.1
symbol: cin-4
gene_biotype: protein_coding
description:
  DNA topoisomerase-like protein cin-4; Plays a role in the removal of cohesin from kinetochores on mitotic chromosomes and is required for centromere resolution. Belongs to the type II topoisomerase family.


ensembl_gene_id: ZK1128.1.1
symbol: ZK1128.1
gene_biotype: protein_coding
description:
  Protein arginine methyltransferase NDUFAF7 homolog, mitochondrial; Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).


ensembl_gene_id: ZK1128.2a.1
symbol: mett-10
gene_biotype: protein_coding
description:
  U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase; RNA N6-methyltransferase that mediates N6-methylation of adenine of U6 small nuclear RNA (U6 snRNA) (By similarity). Involved in mRNA splicing (By similarity). Required for gamete production, inhibiting germ cell proliferative fate and ensuring germ cell meiotic development. Also promotes progression of the mitotic cell cycle in those germ cells that continue to proliferate. Plays a role in the development of the vulva, somatic gonad and embryo. Belongs to the methyltransferase superfamily. METTL16/RlmF family.


ensembl_gene_id: ZK1128.6a.1
symbol: ttll-4
gene_biotype: protein_coding
description:
  Tubulin polyglutamylase ttll-4; Polyglutamylase involved in side-chain polyglutamylation of tubulin in sensory cilia. Together with ttll-5 and ttll-11, required for male mating.


ensembl_gene_id: ZK1128.8b.1
symbol: vps-29
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.


ensembl_gene_id: ZK1193.1.1
symbol: col-19
gene_biotype: protein_coding
description:
  Cuticle collagen 19; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.


ensembl_gene_id: ZK1236.1.1
symbol: ZK1236.1
gene_biotype: protein_coding
description:
  Translation factor GUF1 homolog, mitochondrial; Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.


ensembl_gene_id: ZK1236.3a.1
symbol: sor-1
gene_biotype: protein_coding
description:
  Sop-2-related protein 1; Acts synergistically with sop-2 to maintain the transcriptionally repressive state of homeotic genes throughout development. Not required to initiate repression, but to maintain it during later stages of development. Also required to repress expression of other genes. Binds RNA in a sequence-independent manner.


ensembl_gene_id: ZK1248.14.1
symbol: fzo-1
gene_biotype: protein_coding
description:
  Transmembrane GTPase fzo-1; Probable transmembrane GTPase (By similarity). Mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission (By similarity); Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. Mitofusin subfamily.


ensembl_gene_id: ZK1251.8a.1
symbol: twk-9
gene_biotype: protein_coding
description:
  TWiK family of potassium channels protein 9; Potassium channel protein that may be component of regulatory network that controls ray development and function.


ensembl_gene_id: ZK1251.9a.1
symbol: dcaf-1
gene_biotype: protein_coding
description:
  DDB1- and CUL4-associated factor homolog 1; Component of the cul4-rbx1-ddb1-dcaf1 E3 ubiquitin-protein ligase complex, dcaf1 may function as the substrate recognition module within this complex.


ensembl_gene_id: ZK1290.12.1
symbol: wrt-1
gene_biotype: protein_coding
description:
  Warthog protein 1 C-product; Intercellular signal essential for a variety of patterning events during development.


ensembl_gene_id: ZK1290.3a.1
symbol: rol-8
gene_biotype: protein_coding
description:
  Cuticle collagen 6; Nematode cuticles are composed largely of collagen-like proteins. The cuticle functions both as an exoskeleton and as a barrier to protect the worm from its environment.


ensembl_gene_id: ZK1307.5.1
symbol: sqv-8
gene_biotype: protein_coding
description:
  Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase sqv-8; Glycosyltransferase required for the biosynthesis of the tetrasaccharide (GlcA-Gal-Gal-Xyl-)Ser core linker of heparan sulfate and chondroitin sulfate. May be involved in the biosynthesis of the HNK-1 carbohydrate epitope on glycoproteins. Required for embryonic development. Involved in the elongation of the pharyngeal isthmus during the later stages of embryonic development. Involved in vulval epithelium invagination.


ensembl_gene_id: ZK1320.4.1
symbol: cyp-13A10
gene_biotype: protein_coding
description:
  Putative cytochrome P450 CYP13A10; Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.


ensembl_gene_id: ZK1321.2c.1
symbol: shk-1
gene_biotype: protein_coding
description:
  Potassium voltage-gated channel protein shk-1; Mediates the voltage-dependent potassium ion permeability of excitable membranes. Has an important role in repolarization and in regulating the pattern of action potential firing. Isoform a expresses currents in a more depolarized voltage range than isoform d.


ensembl_gene_id: ZK154.3.1
symbol: mec-7
gene_biotype: protein_coding
description:
  Tubulin beta-1 chain; Tubulin is the major constituent of microtubules (Probable). It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (Probable). Plays a role in mechanosensory transduction (touch sensitivity).


ensembl_gene_id: ZK154.7.1
symbol: adm-4
gene_biotype: protein_coding
description:
  Disintegrin and metalloproteinase domain-containing protein 17 homolog; Metalloprotease (By similarity). Acts together with protease sup-17 to facilitate lin-12/Notch signaling during developmental cell fate decision, including anchor cell/ventral uterine precursor cell decision. By modulating lin-12/Notch signaling, plays a role in germline development.


ensembl_gene_id: ZK177.5.2
symbol: cyp-44A1
gene_biotype: protein_coding
description:
  Probable cytochrome P450 CYP44; Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.


ensembl_gene_id: ZK177.6.1
symbol: fzy-1
gene_biotype: protein_coding
description:
  WD repeat-containing protein fzy-1; Plays a role in metaphase-anaphase transition during meiosis I. Required for embryonic anterior-posterior axis formation ; Belongs to the WD repeat CDC20/Fizzy family.


ensembl_gene_id: ZK180.1.1
symbol: gbb-2
gene_biotype: protein_coding
description:
  Gamma-aminobutyric acid type B receptor subunit 2; Component of a heterodimeric G-protein coupled receptor for GABA, formed by gbb-1 and gbb-2 (By similarity). Within the heterodimeric GABA receptor, only gbb-1 seems to bind agonists, while gbb-2 mediates coupling to G proteins (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (By similarity). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates po [...]


ensembl_gene_id: ZK180.4.1
symbol: sar-1
gene_biotype: protein_coding
description:
  GTP-binding protein SAR1; Involved in transport from the endoplasmic reticulum to the Golgi apparatus; Belongs to the small GTPase superfamily. SAR1 family.


ensembl_gene_id: ZK20.5.2
symbol: rpn-12
gene_biotype: protein_coding
description:
  26S proteasome non-ATPase regulatory subunit 8; Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.


ensembl_gene_id: ZK20.6.1
symbol: nep-1
gene_biotype: protein_coding
description:
  Neprilysin-1; Probable cell surface protease. Required to control the neuronal innervation of pharyngeal pumping. Belongs to the peptidase M13 family.


ensembl_gene_id: ZK287.5.2
symbol: rbx-1
gene_biotype: protein_coding
description:
  RING-box protein 1; Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate (By similarity). Essential for meiosis, mitotic chromosomal condensation and cytokinesis. Involved in histone H3 phosphorylation.


ensembl_gene_id: ZK287.8a.1
symbol: her-1
gene_biotype: protein_coding
description:
  Protein her-1; Dictates male development. Probably plays a direct role in cell signaling during C.elegans sex determination. Inhibits the function of tra-2a.


ensembl_gene_id: ZK328.1b.1
symbol: cyk-3
gene_biotype: protein_coding
description:
  Ubiquitin carboxyl-terminal hydrolase cyk-3; Ubiquitin-protein hydrolase which cleaves ubiquitin from ubiquitinated proteins. Plays a role in embryo osmoregulation. Probably by regulating osmosis, controls actin redistribution in the 1-cell embryos and thus actin-dependent processes such as cytokinesis and P-granules segregation. During the first embryonic mitotic division, involved in the formation of a functional microtubule organizing center provided by the male pronucleus ; Belongs to the peptidase C19 family.


ensembl_gene_id: ZK328.5b.1
symbol: npp-10
gene_biotype: protein_coding
description:
  Nuclear pore complex protein Nup98-Nup96; Nup98 and Nup96 play a role in the bidirectional transport across the nucleoporin complex (NPC). Required for the nuclear import of hcp-4 during mitotic prophase, this step is essential for centrosome assembly and resolution. Regulates nucleoporin npp-5 localization to the nuclear membrane during interphase and to kinetochores during metaphase. Has a role in P granule integrity; may promote the 'liquid phase' of P granules by increasing the number of interacting RNA-protein complexes. Binds nos-2 mRNA, probably indirectly, and promotes its accu [...]


ensembl_gene_id: ZK328.7a.1
symbol: ift-139
gene_biotype: protein_coding
description:
  Tetratricopeptide repeat protein 21 homolog; Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. In particular, may act redundantly with the intraflagellar transport protein ift-43 to regulate the transport of specific ciliary cargo proteins such as che-3 which are related to motility. Functions in cilia biogenesis. Belongs to the TTC21 family.


ensembl_gene_id: ZK353.1b.1
symbol: cyy-1
gene_biotype: protein_coding
description:
  Cyclin-Y; In association with pct-1, regulates the trafficking of synaptic vesicle precursors in DA motor neurons by promoting anterograde trafficking to the axon and preventing dynein-dependent trafficking to the dendrite. May also regulate synaptic vesicle trafficking in DD motor neurons and in RIA interneurons. Involved in synapse formation during DD motor neuron remodeling by disassembling ventral presynaptic structures. May activate cdk-5. Belongs to the cyclin family.


ensembl_gene_id: ZK353.7.1
symbol: cutc-1
gene_biotype: protein_coding
description:
  Copper homeostasis protein cutC homolog; Involved in copper homeostasis. Affects body morphology and length, egg laying and brood size; Belongs to the CutC family.


ensembl_gene_id: ZK353.8.2
symbol: ubxn-4
gene_biotype: protein_coding
description:
  UBX domain-containing protein 4; Probably acts as an adapter for ATPase cdc-48.1 and/or cdc- 48.2, conferring substrate specificity. May play a role in the ER- associated protein degradation pathway (ERAD) possibly acting as a platform to recruit both ubql-1 and cdc-48.1 and/or cdc-48.2 to the ER during ERAD.


ensembl_gene_id: ZK370.3a.1
symbol: hipr-1
gene_biotype: protein_coding
description:
  Huntington interacting protein related 1; Regulates pre-synaptic vesicle recycling at neuromuscular junctions of mechanosensory neurons. Plays a role in maintaining a normal defecation cycle; Belongs to the SLA2 family.


ensembl_gene_id: ZK370.5.1
symbol: pdhk-2
gene_biotype: protein_coding
description:
  Probable [pyruvate dehydrogenase (acetyl-transferring)] kinase, mitochondrial; Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism.


ensembl_gene_id: ZK370.8.1
symbol: tomm-70
gene_biotype: protein_coding
description:
  Mitochondrial import receptor subunit tomm-70; Receptor that accelerates the import of all mitochondrial precursor proteins; Belongs to the Tom70 family.


ensembl_gene_id: ZK377.1.1
symbol: wrt-6
gene_biotype: protein_coding
description:
  Warthog protein 6 C-product; Intercellular signal essential for a variety of patterning events during development; Belongs to the hedgehog family.


ensembl_gene_id: ZK377.2b.1
symbol: sax-3
gene_biotype: protein_coding
description:
  Protein sax-3; Required to confine migrating sex myoblasts to the ventral muscle quadrants during their migration through the body and for multiple aspects of sensory, motor, and interneuron axon guidance. Belongs to the immunoglobulin superfamily. ROBO/SAX3 family.


ensembl_gene_id: ZK381.4b.1
symbol: pgl-1
gene_biotype: protein_coding
description:
  Guanyl-specific ribonuclease pgl-1; Guanyl-specific endoribonuclease which cleaves the phosphodiester bond in single-stranded RNA between the 3'-guanylic residue and the 5'-OH residue of adjacent nucleotide, resulting in the formation of a corresponding 2',3'-cyclic phosphate intermediate. Together with the P-granule component pgl-3, is involved in the formation of P-granules. Together with pgl-3, probably recruits other granule components such as pos-1, mex-3 and glh-1 to P-granules. In addition, may act redundantly with pgl-3 to protect germ cells from excessive germline apoptosis du [...]


ensembl_gene_id: ZK418.1.1
symbol: nhr-9
gene_biotype: protein_coding
description:
  Nuclear hormone receptor family member nhr-9; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family.


ensembl_gene_id: ZK430.1.1
symbol: toe-1
gene_biotype: protein_coding
description:
  HEAT repeat-containing protein 1 homolog; Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in ribosome biosynthesis (By similarity); Belongs to the HEATR1/UTP10 family.


ensembl_gene_id: ZK430.3.1
symbol: sod-5
gene_biotype: protein_coding
description:
  Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family.


ensembl_gene_id: ZK430.8.1
symbol: mlt-7
gene_biotype: protein_coding
description:
  Peroxidase mlt-7 heavy chain; Plays an essential role in cuticle biogenesis. Required in combination with bli-3 for correct formation of cross-links in cuticle collagens.


ensembl_gene_id: ZK455.1.2
symbol: aco-1
gene_biotype: protein_coding
description:
  Probable cytoplasmic aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.


ensembl_gene_id: ZK455.2.1
symbol: gcy-9
gene_biotype: protein_coding
description:
  Receptor-type guanylate cyclase gcy-9; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Involved in the sensing of CO2 levels and acidity by the BAG neurons. May act as a direct receptor for CO2 and H+.


ensembl_gene_id: ZK455.3.1
symbol: npr-9
gene_biotype: protein_coding
description:
  Galanin-like G-protein coupled receptor npr-9; Neuropeptide that controls movement such as roaming, foraging and backwards locomotion or 'reversals' in response to environmental cues such as food availability or volatile odorants such as octanol. Antagonizes AIB interneuron activity to control bacterial colonization and may negatively regulate the expression of immunity-related genes such as pqm-1 and dod-22 in response to infection by P.aeruginosa.


ensembl_gene_id: ZK455.4.1
symbol: asm-2
gene_biotype: protein_coding
description:
  Sphingomyelin phosphodiesterase 2; Converts sphingomyelin to ceramide. Belongs to the acid sphingomyelinase family.


ensembl_gene_id: ZK455.6.1
symbol: hizr-1
gene_biotype: protein_coding
description:
  High zinc activated nuclear receptor protein; Nuclear receptor transcription factor that binds to DNA enhancer elements to promote the transcription of genes required to maintain micronutrient homeostasis. Direct binding to its ligand zinc allows for nuclear accumulation and activation, which thereby induces the transcription of genes required to promote the storage and detoxification of excess dietary zinc. This in turn, allows for internal zinc levels to be detected and regulated.


ensembl_gene_id: ZK455.7.2
symbol: pgp-3
gene_biotype: protein_coding
description:
  Multidrug resistance protein pgp-3; Mediates ATP-dependent export of organic anions and xenobiotics from the cytoplasm. Hydrolyzes ATP with low efficiency (By similarity); Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.


ensembl_gene_id: ZK484.1a.1
symbol: oaz-1
gene_biotype: protein_coding
description:
  Ornithine decarboxylase antizyme; Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin- independent proteolytic destruction by the 26S proteasome.


ensembl_gene_id: ZK488.2.1
symbol: nhr-90
gene_biotype: protein_coding
description:
  Nuclear hormone receptor family member nhr-90; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family.


ensembl_gene_id: ZK507.1.1
symbol: ZK507.1
gene_biotype: protein_coding
description:
  Putative serine/threonine-protein kinase ZK507.1; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.


ensembl_gene_id: ZK507.3.1
symbol: ZK507.3
gene_biotype: protein_coding
description:
  Putative serine/threonine-protein kinase ZK507.3; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.


ensembl_gene_id: ZK507.6.1
symbol: cya-1
gene_biotype: protein_coding
description:
  G2/mitotic-specific cyclin-A1; Involved in the control of the cell cycle after S phase. May bind to and activate cdk-1 and/or cdk-2 to promote cell cycle progression. Necessary for embryogenesis. Belongs to the cyclin family. Cyclin AB subfamily.


ensembl_gene_id: ZK512.4.2
symbol: ZK512.4
gene_biotype: protein_coding
description:
  Signal recognition particle 9 kDa protein; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding (By similarity).


ensembl_gene_id: ZK512.6a.1
symbol: eat-4
gene_biotype: protein_coding
description:
  Probable vesicular glutamate transporter eat-4; Required for glutamatergic synaptic transmission. In AWB and AWC sensory neurons, required for the detection of preferred food sources, probably via glutamatergic neurotransmission from sensory neurons. Negatively regulates the turning step of male mating behavior.


ensembl_gene_id: ZK520.2.1
symbol: sid-2
gene_biotype: protein_coding
description:
  Systemic RNA interference defective protein 2; Plays a role in RNA-mediated gene silencing by mediating endocytic uptake of double-stranded RNA (dsRNA) ingested from the environment into intestinal cells from the intestinal lumen. Selective for dsRNAs of at least 50 bp.


ensembl_gene_id: ZK520.3a.1
symbol: dyf-2
gene_biotype: protein_coding
description:
  WD repeat-containing protein dyf-2; Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Moves along the ciliary axoneme and is involved in the assembly, localization and the movement of other intraflagellar transport (IFT) proteins along the cilia axoneme. May also associate with the BBSome complex in order to mediate ciliary transport. Regulates cilia biogenesis, morphology and sensitivity to environmental cues.


ensembl_gene_id: ZK520.4c.1
symbol: cul-2
gene_biotype: protein_coding
description:
  Cullin-2; Core component of multiple cullin-RING-based CBC (Cul2- ElonginB-ElonginC) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the CBC complex depends on the variable substrate recognition component (By similarity). May function in ubiquitin-mediated degradation of CKIs to target cki-1 for degradation. CBC(zif-1) may ensure germline precursor cell [...]


ensembl_gene_id: ZK520.5.1
symbol: cyn-2
gene_biotype: protein_coding
description:
  Peptidyl-prolyl cis-trans isomerase 2; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.


ensembl_gene_id: ZK524.1.1
symbol: spe-4
gene_biotype: protein_coding
description:
  Presenilin spe-4; Potential catalytic subunit of the gamma-secretase complex during spermatogenesis, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1) (Probable). Involved in spermatid formation during meiosis II. May be required for proper localization of macromolecules that are subject to asymmetric partitioning during spermatogenesis.


ensembl_gene_id: ZK524.2d.1
symbol: unc-13
gene_biotype: protein_coding
description:
  Phorbol ester/diacylglycerol-binding protein unc-13; May form part of a signal transduction pathway, transducing the signal from diacylglycerol to effector functions. One such function could be the release of neurotransmitter from neurons. Probably by regulating neuronal transmission downstream of lin-3 and receptor lin-23 and phospholipase plc-3 and upstream of innexin unc-7 and egl-4/PKG in ALA neurons, involved in the decrease in pharyngeal pumping during the quiescent state that precedes each larval molt.


ensembl_gene_id: ZK54.2a.2
symbol: tps-1
gene_biotype: protein_coding
description:
  Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 1; Catalyzes the production of trehalose from glucose-6- phosphate and UDP-alpha-D-glucose in a 2 step process; In the C-terminal section; belongs to the gob-1 trehalose phosphatase family.


ensembl_gene_id: ZK546.13.1
symbol: mdt-4
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 4; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).


ensembl_gene_id: ZK546.17.1
symbol: cblc-1
gene_biotype: protein_coding
description:
  MMACHC-like protein; Catalyzes the reductive dealkylation of cyanocobalamin to cob(II)alamin, using FAD or FMN as cofactor and NADPH as cosubstrate. Can also catalyze the glutathione-dependent reductive demethylation of methylcobalamin, and, with much lower efficiency, the glutathione- dependent reductive demethylation of adenosylcobalamin. Under anaerobic conditions cob(I)alamin is the first product; it is highly reactive and is converted to aquocob(II)alamin in the presence of oxygen. Binds cyanocobalamin, adenosylcobalamin, methylcobalamin and other, related vitamin B12 derivatives; [...]


ensembl_gene_id: ZK546.1b.1
symbol: zyg-12
gene_biotype: protein_coding
description:
  Zygote defective protein 12; Cytoskeletal linker protein, which is essential for attachment of the centrosome to the nucleus. Required for dynein localization to the nuclear envelope. Forms a LINC (LInker of Nucleoskeleton and Cytoskeleton) complex together with unc-84, that may be involved in DNA damage repair ; Belongs to the hook family.


ensembl_gene_id: ZK546.6.1
symbol: msp-152
gene_biotype: protein_coding
description:
  Major sperm protein 152; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod.


ensembl_gene_id: ZK563.5.2
symbol: sorf-1
gene_biotype: protein_coding
description:
  Suppressor of organelle fusion 1; Together with sorf-2 negatively regulates the levels of phosphatidylinositol 3-phosphate (PtdIns3P) to enable the conversion of early endosomes to late endosomes. Binds to sorf-2 and the sorf-1-sorf- 2 complex likely acts through bec-1, a non-catalytic subunit of phosphatidylinositol 3-kinase (PI3K), to suppress PI3K activity, thereby negatively regulating endosomal PtdIns3P levels. Belongs to the WD repeat WDR91 family.


ensembl_gene_id: ZK593.4a.1
symbol: rbr-2
gene_biotype: protein_coding
description:
  Lysine-specific demethylase rbr-2; Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys- 27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Required for normal longevity of the soma in a germline-dependent manner. Implicated in the epigenetic inheritance of lifespan over several generations. Involved in larval development and vulva formation.


ensembl_gene_id: ZK593.6a.1
symbol: lgg-2
gene_biotype: protein_coding
description:
  Protein lgg-2; Ubiquitin-like modifier involved in the formation of autophagosomal vacuoles (autophagosomes). When lipidated mediates tethering between adjacent membranes and stimulates membrane fusion. Less effective at promoting membrane fusion than lgg-1. Acts upstream of the autophagy protein epg-5 in the aggrephagy pathway, which is the macroautophagic degradation of ubiquitinated protein aggregates, and preferentially interacts with autophagy proteins and substrates containing LIR motifs to mediate autophagosome formation and protein aggregate degradation. In particular binds to  [...]


ensembl_gene_id: ZK593.8.1
symbol: fic-1
gene_biotype: protein_coding
description:
  Protein adenylyltransferase fic-1; Protein that can both mediate the addition of adenosine 5'- monophosphate (AMP) to specific residues of target proteins (AMPylation), and the removal of the same modification from target proteins (de-AMPylation), depending on the context (By similarity). The side chain of Glu-274 determines which of the two opposing activities (AMPylase or de-AMPylase) will take place (By similarity). Adenylyltransferase that mediates the addition of adenosine 5'- monophosphate (AMP) to specific residues of target proteins. In vivo target proteins include the heat-sho [...]


ensembl_gene_id: ZK616.10a.1
symbol: ehn-3
gene_biotype: protein_coding
description:
  Zinc finger protein ehn-3; Together with the zinc finger protein ztf-16, plays a role in gonadogenesis, specifically in somatic gonad precursor cell development. This is possibly by regulating tra-1 gene expression. Belongs to the krueppel C2H2-type zinc-finger protein family.


ensembl_gene_id: ZK617.1b.1
symbol: unc-22
gene_biotype: protein_coding
description:
  Twitchin; Regulator of muscle contraction and relaxation. Senses mechanical strain that occurs during muscle activity by unfolding in clearly resolvable steps at differing forces. Plays a role in the organization of sarcomeres in body wall muscles ; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.


ensembl_gene_id: ZK632.13a.1
symbol: lin-52
gene_biotype: protein_coding
description:
  Protein lin-52; Synthetic multivulva class B (synMuvB) protein. SynMuvB proteins are required to repress the induction of vulval development by Ras signaling and probably act by forming the multiprotein DRM complex that represses transcription. In association with the zinc finger protein ztf-11, negatively regulates the expression of non-neuronal genes during neurogenesis. Belongs to the lin-52 family.


ensembl_gene_id: ZK632.1a.1
symbol: mcm-6
gene_biotype: protein_coding
description:
  DNA replication licensing factor mcm-6; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentia [...]


ensembl_gene_id: ZK632.4.1
symbol: ZK632.4
gene_biotype: protein_coding
description:
  Probable mannose-6-phosphate isomerase; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions.


ensembl_gene_id: ZK632.6a.1
symbol: cnx-1
gene_biotype: protein_coding
description:
  Calnexin; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins (By similarity). Required for embryogenesis and larval development under heat and ER stress conditions. May be important for germ cell development. Involved in neuronal necrotic cell death.


ensembl_gene_id: ZK632.7.1
symbol: panl-3
gene_biotype: protein_coding
description:
  PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...]


ensembl_gene_id: ZK632.8.1
symbol: arl-5
gene_biotype: protein_coding
description:
  ADP-ribosylation factor-like protein 5; GTP-binding protein that may be involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus (By similarity). Plays a role in the shedding of pathogen spores from intestinal cells.


ensembl_gene_id: ZK637.5.1
symbol: asna-1
gene_biotype: protein_coding
description:
  ATPase asna-1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...]


ensembl_gene_id: ZK637.7b.1
symbol: lin-9
gene_biotype: protein_coding
description:
  Protein lin-9; Synthetic multivulva class B (synMuvB) protein. SynMuvB proteins are required to repress the induction of vulval development by Ras signaling and probably act by forming the multiprotein DRM complex that represses transcription. Required for the development of sheath cells in the hermaphrodite gonad and for the development of the male spicule, rays and gonad. In association with the zinc finger protein ztf-11, negatively regulates the expression of non- neuronal genes during neurogenesis.


ensembl_gene_id: ZK637.8a.1
symbol: unc-32
gene_biotype: protein_coding
description:
  Probable V-type proton ATPase 116 kDa subunit a; Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (Probable). Regulates the size of gut granules during embryonic development.


ensembl_gene_id: ZK637.9b.1
symbol: tpk-1
gene_biotype: protein_coding
description:
  Thiamin pyrophosphokinase 1; Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate. Functions cell non-autonomously.


ensembl_gene_id: ZK652.1.1
symbol: snr-5
gene_biotype: protein_coding
description:
  Probable small nuclear ribonucleoprotein F; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5.


ensembl_gene_id: ZK652.3.1
symbol: ufm-1
gene_biotype: protein_coding
description:
  Ubiquitin-fold modifier 1; Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to substrate proteins as a monomer or a lysine- linked polymer (By similarity). The so-called ufmylation requires the ufm-1-activating E1 enzyme uba-5, the ufm-1-conjugating E2 enzyme ufc- 1, and probably the ufm-1-ligase E3 enzyme ufl-1. Belongs to the UFM1 family.


