# geneInfo

ensembl_gene_id: HI_0001
symbol: gapA
gene_biotype: protein_coding
description:
  Glyceraldehyde-3-phosphate dehydrogenase (gapdH); Catalyzes the oxidative phosphorylation of glyceraldehyde 3- phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG.


ensembl_gene_id: HI_0002
symbol: HI_0002
gene_biotype: protein_coding
description:
  Long chain fatty acid coA ligase, putative; Similar to GB:AE000782 percent identity: 34.58; identified by sequence similarity; putative.


ensembl_gene_id: HI_0003
symbol: HI_0003
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:L10328 SP:P09997 PID:290545 PID:41648 GB:U00096 percent identity: 32.69; identified by sequence similarity; putative.


ensembl_gene_id: HI_0004
symbol: ybeY
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.


ensembl_gene_id: HI_0005
symbol: fdhD
gene_biotype: protein_coding
description:
  fdhD protein (fdhD); Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Belongs to the FdhD family.


ensembl_gene_id: HI_0007
symbol: fdxH
gene_biotype: protein_coding
description:
  Formate dehydrogenase, beta subunit (fdxH); Allows to use formate as major electron donor during aerobic respiration. The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers. Electrons are transferred from the gamma chain to the molybdenum cofactor of the alpha subunit (By similarity).


ensembl_gene_id: HI_0008
symbol: fdxI
gene_biotype: protein_coding
description:
  Formate dehydrogenase, gamma subunit (fdxI); Allows to use formate as major electron donor during anaerobic respiration. Subunit gamma is probably the cytochrome b556(FDO) component of the formate dehydrogenase (By similarity).


ensembl_gene_id: HI_0010
symbol: rimI
gene_biotype: protein_coding
description:
  Ribosomal-protein-alanine acetyltransferase (rimI); Acetylates the N-terminal alanine of ribosomal protein S18.


ensembl_gene_id: HI_0011
symbol: holD
gene_biotype: protein_coding
description:
  DNA polymerase III, psi subunit (holD); DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is unknown (By similarity).


ensembl_gene_id: HI_0012
symbol: rsmC
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle; Belongs to the methyltransferase superfamily. RsmC family.


ensembl_gene_id: HI_0013
symbol: era
gene_biotype: protein_coding
description:
  GTP-binding protein (era); An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.


ensembl_gene_id: HI_0014
symbol: rnc
gene_biotype: protein_coding
description:
  Ribonuclease III (rnc); Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.


ensembl_gene_id: HI_0015
symbol: lepB
gene_biotype: protein_coding
description:
  Signal peptidase I (lepB); Similar to GB:K00426 SP:P00803 PID:146600 PID:987643 GB:U00096 percent identity: 46.31; identified by sequence similarity; putative; Belongs to the peptidase S26 family.


ensembl_gene_id: HI_0016
symbol: lepA
gene_biotype: protein_coding
description:
  GTP-binding membrane protein (lepA); Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner.


ensembl_gene_id: HI_0017
symbol: grcA
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Acts as a radical domain for damaged PFL and possibly other radical proteins.


ensembl_gene_id: HI_0018
symbol: ung
gene_biotype: protein_coding
description:
  Uracil DNA glycosylase (ung); Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.


ensembl_gene_id: HI_0019
symbol: miaB
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.


ensembl_gene_id: HI_0020
symbol: HI_0020
gene_biotype: protein_coding
description:
  Transport protein, putative; Similar to GB:U00096 SP:P75763 PID:1786986 percent identity: 59.91; identified by sequence similarity; putative.


ensembl_gene_id: HI_0021
symbol: citXG
gene_biotype: protein_coding
description:
  citG protein (citG); Bifunctional enzyme that catalyzes formation of 2-(5''- triphosphoribosyl)-3'-dephosphocoenzyme-A, and then the transfer of this prosthetic group precursor to the apo-acyl carrier protein (gamma chain) of the citrate lyase to yield the holo-acyl carrier protein. In the C-terminal section; belongs to the CitG/MdcB family.


ensembl_gene_id: HI_0023
symbol: citE
gene_biotype: protein_coding
description:
  Citrate lyase, beta chain (citE); Represents a citryl-ACP lyase; Belongs to the HpcH/HpaI aldolase family. Citrate lyase beta subunit subfamily.


ensembl_gene_id: HI_0025
symbol: citC
gene_biotype: protein_coding
description:
  Citrate lyase ligase (citC); Acetylation of prosthetic group (2-(5''-phosphoribosyl)-3'- dephosphocoenzyme-A) of the gamma subunit of citrate lyase.


ensembl_gene_id: HI_0026
symbol: lipA
gene_biotype: protein_coding
description:
  Lipoate biosynthesis protein A (lipA); Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.


ensembl_gene_id: HI_0027
symbol: lipB
gene_biotype: protein_coding
description:
  Lipoate biosynthesis protein B (lipB); Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.


ensembl_gene_id: HI_0028
symbol: HI_0028
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:L07636 SP:P30977 PID:146621 GB:U00096 PID:1778548 percent identity: 50.59; identified by sequence similarity; putative; Belongs to the UPF0250 family.


ensembl_gene_id: HI_0029
symbol: dacA
gene_biotype: protein_coding
description:
  Penicillin-binding protein 5 (dacA); Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; Belongs to the peptidase S11 family.


ensembl_gene_id: HI_0030
symbol: rlpA
gene_biotype: protein_coding
description:
  Lipoprotein, putative; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.


ensembl_gene_id: HI_0031
symbol: mrdB
gene_biotype: protein_coding
description:
  Rod shape-determining protein (rodA); Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily.


ensembl_gene_id: HI_0033
symbol: rlmH
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA; Belongs to the RNA methyltransferase RlmH family.


ensembl_gene_id: HI_0034
symbol: rsfS
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.


ensembl_gene_id: HI_0035
symbol: HI_0035
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:L10328 SP:P29211 GB:M94104 PID:290534 PID:147371 percent identity: 63.41; identified by sequence similarity; putative.


ensembl_gene_id: HI_0036
symbol: HI_0036
gene_biotype: protein_coding
description:
  ABC transporter, ATP-binding protein; Similar to SP:Q50614 PID:1483552 percent identity: 42.52; identified by sequence similarity; putative.


ensembl_gene_id: HI_0037
symbol: mreB
gene_biotype: protein_coding
description:
  Rod shape-determining protein (mreB); Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.


ensembl_gene_id: HI_0039
symbol: mreD
gene_biotype: protein_coding
description:
  Rod shape-determining protein (mreD); Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins (By similarity); Belongs to the MreD family.


ensembl_gene_id: HI_0040
symbol: HI_0040
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to PID:1944176 percent identity: 47.58; identified by sequence similarity; putative.


ensembl_gene_id: HI_0041
symbol: xthA
gene_biotype: protein_coding
description:
  Exodeoxyribonuclease III (xthA); Major apurinic-apyrimidinic endonuclease of E.coli. It removes the damaged DNA at cytosines and guanines by cleaving on the 3'-side of the AP site by a beta-elimination reaction (By similarity). Belongs to the DNA repair enzymes AP/ExoA family.


ensembl_gene_id: HI_0042
symbol: HI_0042
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to SP:P39219 GB:U00096 PID:1786244 percent identity: 34.95; identified by sequence similarity; putative.


ensembl_gene_id: HI_0043
symbol: HI_0043
gene_biotype: protein_coding
description:
  Conserved hypothetical transmembrane protein; Similar to SP:P45525 GB:U00096 PID:1787582 percent identity: 42.69; identified by sequence similarity; putative.


ensembl_gene_id: HI_0044
symbol: HI_0044
gene_biotype: protein_coding
description:
  Conserved hypothetical transmembrane protein; Similar to SP:P06967 GB:X00547 PID:41284 GB:U00096 PID:1787205 percent identity: 61.47; identified by sequence similarity; putative.


ensembl_gene_id: HI_0045
symbol: HI_0045
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:U14003 SP:P39187 PID:471102 PID:537057 GB:U00096 percent identity: 40.66; identified by sequence similarity; putative.


ensembl_gene_id: HI_0046
symbol: yjdM
gene_biotype: protein_coding
description:
  Alkylphosphonate uptake protein (phnA); Similar to SP:P16680 GB:U14003 PID:147194 PID:536952 GB:U00096 percent identity: 61.32; identified by sequence similarity; putative; Belongs to the YjdM family.


ensembl_gene_id: HI_0047
symbol: eda
gene_biotype: protein_coding
description:
  4-hydroxy-2-oxoglutarate aldolase/2-deydro-3-deoxyphosphogluconate aldolase (eda); Similar to GB:L20897 GB:M87458 GB:X63694 GB:X68871 PID:145827 percent identity: 37.31; identified by sequence similarity; putative; Belongs to the KHG/KDPG aldolase family.


ensembl_gene_id: HI_0048
symbol: HI_0048
gene_biotype: protein_coding
description:
  Oxidoreductase; Similar to GB:AL009126 percent identity: 48.39; identified by sequence similarity; putative; Belongs to the short-chain dehydrogenases/reductases (SDR) family.


ensembl_gene_id: HI_0049
symbol: kdgK
gene_biotype: protein_coding
description:
  2-dehydro-3-deoxygluconokinase (kdgK); Catalyzes the phosphorylation of 2-keto-3-deoxygluconate (KDG) to produce 2-keto-3-deoxy-6-phosphogluconate (KDPG).


ensembl_gene_id: HI_0050
symbol: HI_0050
gene_biotype: protein_coding
description:
  Conserved hypothetical transmembrane protein; Similar to SP:P37675 PID:466716 GB:U00096 PID:1790003 percent identity: 47.93; identified by sequence similarity; putative.


ensembl_gene_id: HI_0051
symbol: HI_0051
gene_biotype: protein_coding
description:
  Conserved hypothetical transmembrane protein; Similar to SP:P37674 PID:466715 GB:U00096 PID:1790002 percent identity: 28.15; identified by sequence similarity; putative.


ensembl_gene_id: HI_0052
symbol: HI_0052
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to SP:P37676 PID:466717 GB:U00096 PID:1790004 percent identity: 27.19; identified by sequence similarity; putative.


ensembl_gene_id: HI_0053
symbol: HI_0053
gene_biotype: protein_coding
description:
  Zinc-type alcohol dehydrogenase; Similar to GB:M96947 SP:Q06004 PID:304153 GB:AL009126 percent identity: 34.47; identified by sequence similarity; putative.


ensembl_gene_id: HI_0055
symbol: uxuA
gene_biotype: protein_coding
description:
  Mannonate dehydratase (uxuA); Catalyzes the dehydration of D-mannonate; Belongs to the mannonate dehydratase family.


ensembl_gene_id: HI_0056
symbol: HI_0056
gene_biotype: protein_coding
description:
  Conserved hypothetical transmembrane protein; Similar to PID:882725 GB:U00096 PID:1789197 percent identity: 61.70; identified by sequence similarity; putative.


ensembl_gene_id: HI_0057
symbol: uvrC
gene_biotype: protein_coding
description:
  Excinuclease ABC, subunit C (uvrC); The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.


ensembl_gene_id: HI_0058
symbol: kdsB
gene_biotype: protein_coding
description:
  3-deoxy-D-manno-octulosonate cytidylyltransferase (kdsB); Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.


ensembl_gene_id: HI_0059
symbol: lpxK
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).


ensembl_gene_id: HI_0060
symbol: msbA
gene_biotype: protein_coding
description:
  ABC transporter, ATP-binding protein (msbA); Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.


ensembl_gene_id: HI_0061
symbol: rec2
gene_biotype: protein_coding
description:
  Recombination protein (rec2); Might contribute to transformation as a member of a membrane- bound pore complex at the base of the transformasome. It could directly interact with transforming DNA during translocation indirectly by participating in the assembly of the pore.


ensembl_gene_id: HI_0062
symbol: dksA
gene_biotype: protein_coding
description:
  dnaK suppressor protein (dksA); Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression.


ensembl_gene_id: HI_0063
symbol: pcnB
gene_biotype: protein_coding
description:
  poly(A) polymerase (pcnB); Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control. Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.


ensembl_gene_id: HI_0064
symbol: folK
gene_biotype: protein_coding
description:
  2-amino-4-hydroxy-6- hydroxymethyldihydropteridine-pyrophosphokinase (folK); Similar to GB:D26562 SP:P26281 GB:L06495 PID:146013 PID:473801 percent identity: 56.33; identified by sequence similarity; putative.


ensembl_gene_id: HI_0065
symbol: tsaE
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaB. TsaE seems to play an indirect role in the t(6)A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD (By similarity). Displays ATPase activity in vitro.


ensembl_gene_id: HI_0066
symbol: amiB
gene_biotype: protein_coding
description:
  N-acetylmuramoyl-L-alanine amidase, putative; Cell-wall hydrolase involved in septum cleavage during cell division; Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family.


ensembl_gene_id: HI_0067
symbol: mutL
gene_biotype: protein_coding
description:
  DNA mismatch repair protein (mutL); This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity).


ensembl_gene_id: HI_0068
symbol: miaA
gene_biotype: protein_coding
description:
  tRNA delta(2)-isopentenylpyrophosphate transferase (trpX); Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family.


ensembl_gene_id: HI_0069
symbol: glnE
gene_biotype: protein_coding
description:
  Glutamate-ammonia-ligase adenylyltransferase (glnE); Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal [...]


ensembl_gene_id: HI_0071
symbol: grpE
gene_biotype: protein_coding
description:
  Heat shock protein (grpE); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of AT [...]


ensembl_gene_id: HI_0072
symbol: nadK
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.


ensembl_gene_id: HI_0075
symbol: nrdD
gene_biotype: protein_coding
description:
  Anaerobic ribonucleoside-triphosphate reductase (nrdD); Catalyzes the conversion of ribonucleotides into deoxyribonucleotides, which are required for DNA synthesis and repair. Belongs to the anaerobic ribonucleoside-triphosphate reductase family.


ensembl_gene_id: HI_0076
symbol: tesB
gene_biotype: protein_coding
description:
  acyl-CoA thioesterase II (tesB); Can hydrolyze a broad range of acyl-CoA thioesters. Its physiological function is not known (By similarity); Belongs to the C/M/P thioester hydrolase family.


ensembl_gene_id: HI_0078
symbol: cysS
gene_biotype: protein_coding
description:
  cysteinyl-tRNA synthetase (cysS); Similar to GB:M59381 SP:P21888 GB:X56234 GB:X59293 PID:145692 percent identity: 75.65; identified by sequence similarity; putative; Belongs to the class-I aminoacyl-tRNA synthetase family.


ensembl_gene_id: HI_0079
symbol: ppiB
gene_biotype: protein_coding
description:
  Peptidyl-prolyl cis-trans isomerase B (ppiB); PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.


ensembl_gene_id: HI_0080
symbol: HI_0080
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:U00096 PID:2367279 percent identity: 43.04; identified by sequence similarity; putative; To E.coli YifN.


ensembl_gene_id: HI_0081
symbol: HI_0081
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:U14003 SP:P39408 PID:537218 GB:U00096 PID:1790838 percent identity: 54.82; identified by sequence similarity; putative.


ensembl_gene_id: HI_0084
symbol: trxA
gene_biotype: protein_coding
description:
  Thioredoxin (trxM); Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.


ensembl_gene_id: HI_0085
symbol: ddh
gene_biotype: protein_coding
description:
  D-lactate dehydrogenase, fermentative (ldhA); Similar to PID:1049265 SP:P52643 GB:U00096 PID:1742253 PID:1742259 percent identity: 70.86; identified by sequence similarity; putative; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.


ensembl_gene_id: HI_0086
symbol: metB
gene_biotype: protein_coding
description:
  Cystathionine gamma-synthase (metB); Catalyzes the formation of L-cystathionine from O-succinyl-L- homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction. In the absence of thiol, catalyzes gamma-elimination to form 2- oxobutanoate, succinate and ammonia (By similarity).


ensembl_gene_id: HI_0087
symbol: thrC
gene_biotype: protein_coding
description:
  Threonine synthase (thrC); Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine.


ensembl_gene_id: HI_0088
symbol: thrB
gene_biotype: protein_coding
description:
  Homoserine kinase (thrB); Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.


ensembl_gene_id: HI_0089
symbol: thrA
gene_biotype: protein_coding
description:
  Aspartokinase I / homoserine dehydrogenase I (thrA); Similar to SP:P00561 GB:M10644 GB:V00360 GB:V00361 PID:147979 percent identity: 62.21; identified by sequence similarity; putative; In the C-terminal section; belongs to the homoserine dehydrogenase family.


ensembl_gene_id: HI_0090
symbol: HI_0090
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.


ensembl_gene_id: HI_0091
symbol: glxK
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to SP:P42100 PID:563934 PID:904179 GB:AL009126 percent identity: 59.46; identified by sequence similarity; putative.


ensembl_gene_id: HI_0093
symbol: HI_0093
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to SP:P37047 GB:U00096 PID:1552740 PID:1786357 percent identity: 35.90; identified by sequence similarity; putative; Belongs to the CdaR family.


ensembl_gene_id: HI_0095
symbol: HI_0095
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GP:2104289 percent identity: 34.43; identified by sequence similarity; putative.


ensembl_gene_id: HI_0097
symbol: fbpA
gene_biotype: protein_coding
description:
  iron(III) ABC transporter, periplasmic-binding protein (hitA); Part of the ABC transporter complex FbpABC (TC 3.A.1.10.1) involved in Fe(3+) ions import. This protein specifically binds Fe(3+) and is involved in its transmembrane transport (By similarity). Belongs to the bacterial solute-binding protein 1 family.


ensembl_gene_id: HI_0098
symbol: fbpB2
gene_biotype: protein_coding
description:
  iron(III) ABC transporter, permease protein (hitB); Part of the ABC transporter complex FbpABC (TC 3.A.1.10.1) involved in Fe(3+) ions import. Probably responsible for the translocation of the substrate across the membrane (By similarity).


ensembl_gene_id: HI_0099
symbol: fbpC2
gene_biotype: protein_coding
description:
  iron(III) ABC transporter, ATP-binding protein (hitC); Part of the ABC transporter complex FbpABC involved in Fe(3+) ions import. Responsible for energy coupling to the transport system.


ensembl_gene_id: HI_0102
symbol: dapE
gene_biotype: protein_coding
description:
  Succinyl-diaminopimelate desuccinylase (dapE); Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls. It can only hydrolyze L,L-N-succinyl-diaminopimelic acid (L,L- SDAP) and is inactive toward D,L-, L,D-, and D,D-SDAP.


ensembl_gene_id: HI_0103
symbol: HI_0103
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to SP:P24178 GB:X57403 PID:41233 GB:U00096 PID:1788815 percent identity: 48.70; identified by sequence similarity; putative; Belongs to the ArsC family.


ensembl_gene_id: HI_0105
symbol: HI_0105
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:U00096 SP:P75743 PID:1786928 percent identity: 64.26; identified by sequence similarity; putative.


ensembl_gene_id: HI_0106
symbol: ffh
gene_biotype: protein_coding
description:
  Signal recognition particle protein (ffh); Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual co [...]


ensembl_gene_id: HI_0107
symbol: HI_0107
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:U00096 PID:1788966 percent identity: 64.81; identified by sequence similarity; putative.


ensembl_gene_id: HI_0108
symbol: HI_0108
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:U14003 SP:P39402 PID:537207 GB:U00096 PID:1790826 percent identity: 39.25; identified by sequence similarity; putative.


ensembl_gene_id: HI_0110
symbol: serS
gene_biotype: protein_coding
description:
  seryl-tRNA synthetase (serS); Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec).


ensembl_gene_id: HI_0111
symbol: gst
gene_biotype: protein_coding
description:
  Glutathione transferase (bphH); Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles; Belongs to the GST superfamily. Beta family.


ensembl_gene_id: HI_0112
symbol: HI_0112
gene_biotype: protein_coding
description:
  Predicted coding region HI0112; Hypothetical protein; identified by GeneMark; putative; Belongs to the IS150/IS1296 orfA family.


ensembl_gene_id: HI_0118
symbol: tcdA
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Catalyzes the ATP-dependent dehydration of threonylcarbamoyladenosine at position 37 (t(6)A37) to form cyclic t(6)A37 (ct(6)A37) in tRNAs that read codons beginning with adenine. Belongs to the HesA/MoeB/ThiF family.


ensembl_gene_id: HI_0119
symbol: znuA
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Involved in the high-affinity zinc uptake transport system. Belongs to the bacterial solute-binding protein 9 family.


ensembl_gene_id: HI_0121
symbol: mpl
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl- meso-diaminopimelate by linking it to UDP-N-acetylmuramate. Belongs to the MurCDEF family. Mpl subfamily.


ensembl_gene_id: HI_0122
symbol: metC
gene_biotype: protein_coding
description:
  Cystathionine beta-lyase (metC); Catalyzes the cleavage of cystathionine to homocysteine, pyruvate and ammonia during methionine biosynthesis.


ensembl_gene_id: HI_0123
symbol: pgsA
gene_biotype: protein_coding
description:
  Phosphatidylglycerophosphate synthase (pgsA); This protein catalyzes the committed step to the synthesis of the acidic phospholipids; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.


ensembl_gene_id: HI_0124
symbol: ppa
gene_biotype: protein_coding
description:
  Inorganic pyrophosphatase (ppa); Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.


ensembl_gene_id: HI_0125
symbol: HI_0125
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to SP:P32702 PID:396399 GB:U00096 PID:1790499 percent identity: 75.90; identified by sequence similarity; putative.


ensembl_gene_id: HI_0126
symbol: fbpC1
gene_biotype: protein_coding
description:
  Ferric ABC transporter, ATP-binding protein (afuC); Part of the ABC transporter complex FbpABC involved in Fe(3+) ions import. Responsible for energy coupling to the transport system.


ensembl_gene_id: HI_0129
symbol: fbpB1
gene_biotype: protein_coding
description:
  Predicted coding region HI0129; Part of the ABC transporter complex FbpABC (TC 3.A.1.10.1) involved in Fe(3+) ions import. Probably responsible for the translocation of the substrate across the membrane (By similarity).


ensembl_gene_id: HI_0131
symbol: HI_0131
gene_biotype: protein_coding
description:
  afuA protein; Similar to PID:1469286 PID:1477455 percent identity: 74.57; identified by sequence similarity; putative.


ensembl_gene_id: HI_0132
symbol: udk
gene_biotype: protein_coding
description:
  Uridine kinase (udk); Similar to SP:P31218 GB:X71492 PID:296947 GB:U00096 PID:1736770 percent identity: 67.82; identified by sequence similarity; putative.


ensembl_gene_id: HI_0135
symbol: sotB
gene_biotype: protein_coding
description:
  Conserved hypothetical transmembrane protein; Involved in the efflux of sugars. The physiological role may be the reduction of the intracellular concentration of toxic sugars or sugar metabolites; Belongs to the major facilitator superfamily. SotB (TC 2.A.1.2) family.


ensembl_gene_id: HI_0136
symbol: der
gene_biotype: protein_coding
description:
  GTP-binding protein; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.


ensembl_gene_id: HI_0137
symbol: dnaQ
gene_biotype: protein_coding
description:
  DNA polymerase III, epsilon subunit (dnaQ); DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease (By similarity).


ensembl_gene_id: HI_0139
symbol: ompP2
gene_biotype: protein_coding
description:
  Outer membrane protein P2 (ompP2); Forms pores that allow passive diffusion of small molecules across the outer membrane.


ensembl_gene_id: HI_0140
symbol: nagA
gene_biotype: protein_coding
description:
  N-acetylglucosamine-6-phosphate deacetylase (nagA); Involved in the first committed step in the biosynthesis of amino-sugar-nucleotides. Catalyzes the hydrolysis of the N-acetyl group of N-acetylglucosamine-6-phosphate (GlcNAc-6-P) to yield glucosamine 6- phosphate and acetate.


ensembl_gene_id: HI_0141
symbol: nagB
gene_biotype: protein_coding
description:
  Glucosamine-6-phosphate isomerase (nagB); Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.


ensembl_gene_id: HI_0142
symbol: nanA
gene_biotype: protein_coding
description:
  N-acetylneuraminate lyase (nanA); Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate; Belongs to the DapA family. NanA subfamily.


ensembl_gene_id: HI_0143
symbol: HI_0143
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:M81878 SP:P26833 PID:144859 percent identity: 34.08; identified by sequence similarity; putative.


ensembl_gene_id: HI_0144
symbol: nanK
gene_biotype: protein_coding
description:
  Glucose kinase, putative; Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P; Belongs to the ROK (NagC/XylR) family. NanK subfamily.


ensembl_gene_id: HI_0145
symbol: nanE
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N- acetylglucosamine-6-phosphate (GlcNAc-6-P).


ensembl_gene_id: HI_0146
symbol: siaP
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Part of the tripartite ATP-independent periplasmic (TRAP) transport system SiaPT involved in the uptake of sialic acid. This protein specifically binds sialic acid with high affinity.


ensembl_gene_id: HI_0147
symbol: siaT
gene_biotype: protein_coding
description:
  Conserved hypothetical transmembrane protein; Part of the tripartite ATP-independent periplasmic (TRAP) transport system SiaPT involved in the uptake of sialic acid. In the N-terminal section; belongs to the TRAP transporter small permease family.


ensembl_gene_id: HI_0148
symbol: nanM
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta- anomer, accelerating the equilibrium between the alpha- and beta- anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses (By similarity); Belongs to the NanM family.


ensembl_gene_id: HI_0152
symbol: HI_0152
gene_biotype: protein_coding
description:
  Predicted coding region HI0152; May transfer the 4'-phosphopantetheine moiety from coenzyme A (CoA) to a serine residue of a carrier protein domain; Belongs to the P-Pant transferase superfamily. Gsp/Sfp/HetI/AcpT family.


ensembl_gene_id: HI_0154
symbol: acpP
gene_biotype: protein_coding
description:
  Acyl carrier protein (acpP); Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family.


ensembl_gene_id: HI_0155
symbol: fabG
gene_biotype: protein_coding
description:
  3-ketoacyl-acyl carrier protein reductase (fabG); Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis; Belongs to the short-chain dehydrogenases/reductases (SDR) family.


ensembl_gene_id: HI_0156
symbol: fabD
gene_biotype: protein_coding
description:
  Malonyl CoA-acyl carrier protein transacylase (fabD); Similar to GB:M87040 SP:P25715 GB:Z11565 PID:145887 PID:41364 percent identity: 70.97; identified by sequence similarity; putative; Belongs to the FabD family.


ensembl_gene_id: HI_0157
symbol: fabH
gene_biotype: protein_coding
description:
  beta-ketoacyl-ACP synthase III (fabH); Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.


ensembl_gene_id: HI_0158
symbol: rpmF
gene_biotype: protein_coding
description:
  Ribosomal protein L32 (rpL32); Similar to GB:M29698 SP:P02435 PID:147712 GB:U00096 PID:1651531 percent identity: 77.19; identified by sequence similarity; putative; Belongs to the bacterial ribosomal protein bL32 family.


ensembl_gene_id: HI_0160
symbol: psd
gene_biotype: protein_coding
description:
  Phosphatidylserine decarboxylase proenzyme (psd); Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).


ensembl_gene_id: HI_0161
symbol: gor
gene_biotype: protein_coding
description:
  Glutathione reductase (gor); Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.


ensembl_gene_id: HI_0162
symbol: HI_0162
gene_biotype: protein_coding
description:
  Lipoprotein, putative; Similar to GB:U00096 PID:1773118 PID:1786637 percent identity: 25.82; identified by sequence similarity; putative.


ensembl_gene_id: HI_0163
symbol: bolA
gene_biotype: protein_coding
description:
  Transcriptional regulator, putative (bolA); Transcriptional regulator that plays an important role in general stress response.


ensembl_gene_id: HI_0164
symbol: nqrA
gene_biotype: protein_coding
description:
  NADH:ubiquinone oxidoreducatase subunit A, Na translocating; NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.


ensembl_gene_id: HI_0166
symbol: nqrB
gene_biotype: protein_coding
description:
  NADH:ubiquinone oxidoreductase, subunit B (nqrB); NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.


ensembl_gene_id: HI_0167
symbol: nqrC
gene_biotype: protein_coding
description:
  NADH:ubiquinone oxidoreductase, Na translocating; NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.


ensembl_gene_id: HI_0168
symbol: nqrD
gene_biotype: protein_coding
description:
  NADH:ubiquinone oxidoreductase, Na translocating; NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol; Belongs to the NqrDE/RnfAE family.


ensembl_gene_id: HI_0171
symbol: nqrF
gene_biotype: protein_coding
description:
  Nqr6 subunit of Na-translocating NADH-quinone reductase complex beta-subunit (nqr6); NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway.


ensembl_gene_id: HI_0172
symbol: apbE
gene_biotype: protein_coding
description:
  Lipoprotein, putative; Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein such as NqrB and NqrC, two subunits of the NQR complex; Belongs to the ApbE family.


ensembl_gene_id: HI_0174
symbol: mnmA
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.


ensembl_gene_id: HI_0176
symbol: rluD
gene_biotype: protein_coding
description:
  sfhB protein (sfhB); Responsible for synthesis of pseudouridine from uracil at positions 1911, 1915 and 1917 in 23S ribosomal RNA; Belongs to the pseudouridine synthase RluA family.


ensembl_gene_id: HI_0177
symbol: bamD
gene_biotype: protein_coding
description:
  Lipoprotein, putative; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.


ensembl_gene_id: HI_0178
symbol: pe
gene_biotype: protein_coding
description:
  Predicted coding region HI0178; Acts as a multifunctional adhesin involved in direct interactions with host epithelial cells and host proteins.


ensembl_gene_id: HI_0179
symbol: pflA
gene_biotype: protein_coding
description:
  Pyruvate formate-lyase activating enzyme (act); Activation of pyruvate formate-lyase 1 under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family.


ensembl_gene_id: HI_0180
symbol: pflB
gene_biotype: protein_coding
description:
  Formate acetyltransferase (pfl); Similar to GB:X08035 SP:P09373 PID:42370 GB:U00096 PID:1651427 percent identity: 86.09; identified by sequence similarity; putative.


ensembl_gene_id: HI_0181
symbol: focA
gene_biotype: protein_coding
description:
  Formate transporter; Involved in the bidirectional transport of formate. Belongs to the FNT transporter (TC 2.A.44) family.


ensembl_gene_id: HI_0182
symbol: nagK
gene_biotype: protein_coding
description:
  Sugar kinase, putative; Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P.


ensembl_gene_id: HI_0183
symbol: HI_0183
gene_biotype: protein_coding
description:
  Amino acid carrier protein, putative; Similar to PID:757741 SP:Q45068 PID:1405464 GB:AL009126 percent identity: 47.97; identified by sequence similarity; putative.


ensembl_gene_id: HI_0184
symbol: HI_0184
gene_biotype: protein_coding
description:
  Esterase; Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate (By similarity).


ensembl_gene_id: HI_0185
symbol: frmA
gene_biotype: protein_coding
description:
  Alcohol dehydrogenase, class III (adhC); Similar to SP:P25437 PID:887431 GB:U00096 PID:1786552 PID:2443392 percent identity: 89.97; identified by sequence similarity; putative; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.


ensembl_gene_id: HI_0186
symbol: HI_0186
gene_biotype: protein_coding
description:
  Transcriptional regulator, putative; Similar to GB:D26185 SP:P37510 PID:467364 GB:AL009126 percent identity: 43.40; identified by sequence similarity; putative.


ensembl_gene_id: HI_0188
symbol: tatC
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.


ensembl_gene_id: HI_0189
symbol: gdhA
gene_biotype: protein_coding
description:
  Glutamate dehydrogenase (gdhA); Catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate and ammonia.


ensembl_gene_id: HI_0190
symbol: fur
gene_biotype: protein_coding
description:
  Ferric uptake regulation protein (fur); Acts as a global negative controlling element, employing Fe(2+) as a cofactor to bind the operator of the repressed genes.


ensembl_gene_id: HI_0191
symbol: fldA
gene_biotype: protein_coding
description:
  Flavodoxin (fldA); Low-potential electron donor to a number of redox enzymes. Belongs to the flavodoxin family.


ensembl_gene_id: HI_0192
symbol: seqA
gene_biotype: protein_coding
description:
  seqA protein (seqA); Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated.


ensembl_gene_id: HI_0193
symbol: HI_0193
gene_biotype: protein_coding
description:
  Esterase/lipase, putative; Similar to GB:U00096 PID:1786902 percent identity: 43.65; identified by sequence similarity; putative; Belongs to the DmpD/TodF/XylF esterase family.


ensembl_gene_id: HI_0194
symbol: menE
gene_biotype: protein_coding
description:
  O-succinylbenzoate--CoA ligase (menE); Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl-CoA (OSB-CoA); Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily.


ensembl_gene_id: HI_0195.1
symbol: HI_0195.1
gene_biotype: protein_coding
description:
  Conserved hypothetical transmembrane protein (aefA); Similar to GB:U00096 SP:P77338 PID:1707458 PID:1773147 PID:1786670 percent identity: 37.35; identified by sequence similarity; putative.


ensembl_gene_id: HI_0196
symbol: aroC
gene_biotype: protein_coding
description:
  Chorismate synthase (aroC); Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.


ensembl_gene_id: HI_0197
symbol: mepA
gene_biotype: protein_coding
description:
  Penicillin-insensitive murein endopeptidase (mepA); Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus.


ensembl_gene_id: HI_0198
symbol: HI_0198
gene_biotype: protein_coding
description:
  Conserved hypothetical transmembrane protein; Similar to SP:P14008 PID:41996 GB:U00096 PID:1788667 percent identity: 53.69; identified by sequence similarity; putative.


ensembl_gene_id: HI_0199
symbol: lpxM
gene_biotype: protein_coding
description:
  Lipid A biosynthesis (kdo)2-(lauroyl)-lipid IVA acyltransferase (msbB); Catalyzes the transfer of myristate from myristoyl-acyl carrier protein (ACP) to Kdo(2)-(lauroyl)-lipid IV(A) to form Kdo(2)- lipid A.


ensembl_gene_id: HI_0201
symbol: rplS
gene_biotype: protein_coding
description:
  Ribosomal protein L19 (rpL19); This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.


ensembl_gene_id: HI_0202
symbol: trmD
gene_biotype: protein_coding
description:
  tRNA (guanine-N1)-methyltransferase (trmD); Specifically methylates guanosine-37 in various tRNAs. Belongs to the RNA methyltransferase TrmD family.


ensembl_gene_id: HI_0203
symbol: rimM
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes; Belongs to the RimM family.


ensembl_gene_id: HI_0204
symbol: rpsP
gene_biotype: protein_coding
description:
  Ribosomal protein S16 (rpS16); Similar to SP:P02372 PID:43143 GB:U00096 PID:1788961 percent identity: 70.73; identified by sequence similarity; putative; Belongs to the bacterial ribosomal protein bS16 family.


ensembl_gene_id: HI_0206
symbol: HI_0206
gene_biotype: protein_coding
description:
  5'-nucleotidase, putative; Degrades NAD into adenosine and nicotinamide riboside, the latter being subsequently internalized by a specific permease. Also endowed with NAD(P) pyrophosphatase activity. Exhibits a broad substrate specificity, recognizing either mono- or dinucleotide nicotinamides and different adenosine phosphates with a maximal activity on 5'-adenosine monophosphate; Belongs to the 5'-nucleotidase family.


ensembl_gene_id: HI_0207
symbol: aroK
gene_biotype: protein_coding
description:
  Shikimic acid kinase I (aroK); Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family.


ensembl_gene_id: HI_0208
symbol: aroB
gene_biotype: protein_coding
description:
  3-dehydroquinate synthase (aroB); Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.


ensembl_gene_id: HI_0209
symbol: dam
gene_biotype: protein_coding
description:
  DNA adenine methylase (dam); Methylates DNA within the sequence GATC. Directly involved in methyl-directed DNA mismatch repair; Belongs to the N(4)/N(6)-methyltransferase family.


ensembl_gene_id: HI_0211
symbol: pgpB
gene_biotype: protein_coding
description:
  Phosphatidylglycerophosphatase B (pgpB); Catalyzes the dephosphorylation of diacylglycerol diphosphate (DGPP) to phosphatidate (PA) and the subsequent dephosphorylation of PA to diacylglycerol (DAG). Also has undecaprenyl pyrophosphate phosphatase activity, required for the biosynthesis of the lipid carrier undecaprenyl phosphate. Can also use lysophosphatidic acid (LPA) and phosphatidylglycerophosphate as substrates. The pattern of activities varies according to subcellular location, PGP phosphatase activity is higher in the cytoplasmic membrane, whereas PA and LPA phosphatase activit [...]


ensembl_gene_id: HI_0212
symbol: ribA
gene_biotype: protein_coding
description:
  GTP cyclohydrolase II (ribA); Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family.


ensembl_gene_id: HI_0213
symbol: HI_0213
gene_biotype: protein_coding
description:
  Oligopeptide transporter, periplasmic-binding protein, putative; Part of a binding-protein-dependent transport system. Belongs to the bacterial solute-binding protein 5 family.


ensembl_gene_id: HI_0214
symbol: prlC
gene_biotype: protein_coding
description:
  Oligopeptidase A (prlC); May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) (By similarity).


ensembl_gene_id: HI_0216
symbol: HI_0216
gene_biotype: protein_coding
description:
  Type I restriction/modification specificity protein (hsdS); The M and S subunits together form a methyltransferase (MTase) that methylates two adenine residues in complementary strands of a bipartite DNA recognition sequence. Subunit S dictates DNA sequences specificity (By similarity).


ensembl_gene_id: HI_0217
symbol: HI_0217
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to PID:984584 GB:U00096 SP:Q47152 PID:1552796 PID:1786422 percent identity: 48.05; identified by sequence similarity; putative; Belongs to the transposase 17 family. RAYT subfamily.


ensembl_gene_id: HI_0219
symbol: HI_0219
gene_biotype: protein_coding
description:
  Conserved hypothetical transmembrane protein; Similar to GB:S68137 SP:P46928 PID:469476 percent identity: 84.69; identified by sequence similarity; putative.


ensembl_gene_id: HI_0220.1
symbol: birA
gene_biotype: protein_coding
description:
  Biotin operon repressor/biotin acetyl coenzyme A carboxylase synthetase (birA); Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon.


ensembl_gene_id: HI_0220.2
symbol: HI_0220.2
gene_biotype: protein_coding
description:
  Predicted coding region HI0220.2; Hypothetical protein; identified by GeneMark; putative; Belongs to the uracil-DNA glycosylase (UDG) superfamily.


ensembl_gene_id: HI_0221
symbol: guaB
gene_biotype: protein_coding
description:
  Inosine-5'-monophosphate dehydrogenase (guaB); Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.


ensembl_gene_id: HI_0221.1
symbol: HI_0221.1
gene_biotype: protein_coding
description:
  Predicted coding region HI0221.1; Brute Force ORF; identified by GeneMark; putative; Belongs to the IMPDH/GMPR family.


ensembl_gene_id: HI_0223
symbol: HI_0223
gene_biotype: protein_coding
description:
  rarD protein, putative; Similar to SP:P27844 percent identity: 25.08; identified by sequence similarity; putative.


ensembl_gene_id: HI_0224
symbol: HI_0224
gene_biotype: protein_coding
description:
  Transcriptional regulator, putative; Similar to SP:P55658 PID:2182633 percent identity: 38.19; identified by sequence similarity; putative.


ensembl_gene_id: HI_0225
symbol: nhaA
gene_biotype: protein_coding
description:
  Na+/H+ antiporter (nhaA); Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons; Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.


ensembl_gene_id: HI_0226
symbol: brnQ
gene_biotype: protein_coding
description:
  Branched chain amino acid transport system II carrier protein (brnQ); Component of the transport system for branched-chain amino acids (leucine, isoleucine and valine) Which is coupled to a proton motive force.


ensembl_gene_id: HI_0227
symbol: HI_0227
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to SP:P37673 PID:466714 GB:U00096 PID:1790001 percent identity: 31.37; identified by sequence similarity; putative; Belongs to the TabA/YhcH/YiaL family.


ensembl_gene_id: HI_0229
symbol: pnp
gene_biotype: protein_coding
description:
  Polynucleotide phosphorylase (pnp); Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction.


ensembl_gene_id: HI_0231
symbol: deaD
gene_biotype: protein_coding
description:
  ATP-dependent RNA helicase (deaD); DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation.


ensembl_gene_id: HI_0232
symbol: mltF
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella. In the N-terminal section; belongs to the bacterial solute- binding protein 3 family.


ensembl_gene_id: HI_0235
symbol: arfA
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Rescues ribosomes stalled at the 3' end of non-stop mRNAs. Recruits release factor 2 (RF2) to the stalled ribosome, helping position it correctly in the ribosomal A site so its GGQ motif can hydrolyze the peptidyl-tRNA bond (By similarity).


ensembl_gene_id: HI_0236
symbol: arsC
gene_biotype: protein_coding
description:
  Arsenate reductase, putative; Reduction of arsenate [As(V)] to arsenite [As(III)]. Belongs to the ArsC family.


ensembl_gene_id: HI_0239
symbol: secF
gene_biotype: protein_coding
description:
  Protein-export membrane protein (secF); Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.


ensembl_gene_id: HI_0240
symbol: secD
gene_biotype: protein_coding
description:
  Protein-export membrane protein (secD); Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.


ensembl_gene_id: HI_0241
symbol: yajC
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions.


ensembl_gene_id: HI_0242
symbol: HI_0242
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:L77117 SP:Q58397 PID:1591652 percent identity: 35.71; identified by sequence similarity; putative; Belongs to the sulfur carrier protein TusA family.


ensembl_gene_id: HI_0244
symbol: tgt
gene_biotype: protein_coding
description:
  tRNA-guanine transglycosylase (tgt); Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to for [...]


ensembl_gene_id: HI_0245
symbol: queA
gene_biotype: protein_coding
description:
  Queuosine biosynthesis protein (queA); Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).


ensembl_gene_id: HI_0249
symbol: uvrA
gene_biotype: protein_coding
description:
  Excinuclease ABC, subunit A (uvrA); The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.


ensembl_gene_id: HI_0250
symbol: ssb
gene_biotype: protein_coding
description:
  Single-stranded DNA binding protein (ssb); Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.


ensembl_gene_id: HI_0251
symbol: tonB
gene_biotype: protein_coding
description:
  tonB protein; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Required for heme utilization and virulence; Belongs to the TonB family.


ensembl_gene_id: HI_0252
symbol: exbD
gene_biotype: protein_coding
description:
  Biopolymer transport protein (exbD); Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates.


ensembl_gene_id: HI_0253
symbol: exbB
gene_biotype: protein_coding
description:
  Biopolymer transport protein (exbB); Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates. Protects ExbD from proteolytic degradation and functionally stabilizes TonB (By similarity).


ensembl_gene_id: HI_0254
symbol: bcp
gene_biotype: protein_coding
description:
  Bacterioferritin comigratory protein (bcp); Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events; Belongs to the peroxiredoxin family. BCP/PrxQ subfamily.


ensembl_gene_id: HI_0255
symbol: dapA
gene_biotype: protein_coding
description:
  Dihydrodipicolinate synthetase (dapA); Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).


ensembl_gene_id: HI_0256
symbol: HI_0256
gene_biotype: protein_coding
description:
  Lipoprotein, putative; Similar to SP:P21167 PID:147409 PID:42126 GB:U00096 PID:1788822 percent identity: 28.37; identified by sequence similarity; putative.


ensembl_gene_id: HI_0257
symbol: yfiA
gene_biotype: protein_coding
description:
  Sigma(54) modulation protein, putative; During stationary phase, prevents 70S dimer formation, probably in order to regulate translation efficiency during transition between the exponential and the stationary phases. In addition, during environmental stress such as cold shock or excessive cell density at stationary phase, stabilizes the 70S ribosome against dissociation, inhibits translation initiation and increase translation accuracy. When normal growth conditions are restored, is quickly released from the ribosome (By similarity); Belongs to the HPF/YfiA ribosome-associated protein  [...]


ensembl_gene_id: HI_0258
symbol: HI_0258
gene_biotype: protein_coding
description:
  Glycosyl transferase, putative; Similar to PID:1857120 percent identity: 38.06; identified by sequence similarity; putative; Belongs to the glycosyltransferase 8 family.


ensembl_gene_id: HI_0260
symbol: HI_0260
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.


ensembl_gene_id: HI_0260.1
symbol: kdkA
gene_biotype: protein_coding
description:
  Predicted coding region HI0260.1; Catalyzes the ATP-dependent phosphorylation of the 3-deoxy-D- manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position. To a lesser extent, can use GTP instead of ATP as substrate.


ensembl_gene_id: HI_0261
symbol: opsX
gene_biotype: protein_coding
description:
  Lipopolysaccharide biosynthesis protein, putative; Catalyzes heptose transfer to the lipopolysaccharide core. It transfers the first L-glycero-D-manno-heptose to the phosphorylated 3- deoxy-alpha-D-manno-octulosonic acid (Kdo-P) of the inner core. Belongs to the glycosyltransferase 9 family.


ensembl_gene_id: HI_0262
symbol: hxuC
gene_biotype: protein_coding
description:
  Heme-hemopexin utilization protein C; Required for utilization of free heme at low concentrations. Belongs to the TonB-dependent receptor family.


ensembl_gene_id: HI_0263
symbol: hxuB
gene_biotype: protein_coding
description:
  Heme-hemopexin utilization protein B (hxuB); Likely functions in the release of soluble HxuA from the cell; Belongs to the TPS (TC 1.B.20) family.


ensembl_gene_id: HI_0265
symbol: folB
gene_biotype: protein_coding
description:
  Dihydroneopterin aldolase, putative; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. Can use L-threo-dihydroneopterin and D-erythro-dihydroneopterin as substrates for the formation of 6- hydroxymethyldihydropterin, but it can also catalyze the epimerization of carbon 2' of dihydroneopterin to dihydromonapterin.


ensembl_gene_id: HI_0266
symbol: plsY
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.


ensembl_gene_id: HI_0267
symbol: narQ
gene_biotype: protein_coding
description:
  Nitrate/nitrite sensor protein (narQ); Probable member of a two-component regulatory system. It is not known what protein it phosphorylates and in which regulatory pathway it acts, as the narL and other nar genes do not exist in H.influenzae.


ensembl_gene_id: HI_0269
symbol: rpoH
gene_biotype: protein_coding
description:
  RNA polymerase sigma-32 factor (rpoH); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes.


ensembl_gene_id: HI_0270
symbol: dusC
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U16 in tRNAs. Belongs to the Dus family. DusC subfamily.


ensembl_gene_id: HI_0271
symbol: djlA
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB/RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host.


ensembl_gene_id: HI_0272
symbol: pyrE
gene_biotype: protein_coding
description:
  Orotate phosphoribosyltransferase (pyrE); Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).


ensembl_gene_id: HI_0273
symbol: rph
gene_biotype: protein_coding
description:
  Ribonuclease PH (rph); Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.


ensembl_gene_id: HI_0274
symbol: gltX
gene_biotype: protein_coding
description:
  glutamyl-tRNA synthetase (gltX); Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).


ensembl_gene_id: HI_0276
symbol: HI_0276
gene_biotype: protein_coding
description:
  Ribonuclease BN (rbn); Similar to GB:L19201 SP:P32146 PID:304990 GB:U00096 PID:1790319 percent identity: 45.06; identified by sequence similarity; putative.


ensembl_gene_id: HI_0277
symbol: HI_0277
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:L20251 SP:P37052 PID:410154 GB:U00096 PID:1787484 percent identity: 37.16; identified by sequence similarity; putative; Belongs to the UPF0225 family.


ensembl_gene_id: HI_0280
symbol: udp
gene_biotype: protein_coding
description:
  Uridine phosphorylase (udp); Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity).


ensembl_gene_id: HI_0281
symbol: HI_0281
gene_biotype: protein_coding
description:
  Transport protein, putative; Similar to SP:P37643 PID:466660 GB:U00096 PID:1789941 percent identity: 55.42; identified by sequence similarity; putative.


ensembl_gene_id: HI_0282
symbol: menH
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Catalyzes a proton abstraction reaction that results in 2,5- elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6- hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC).


ensembl_gene_id: HI_0283
symbol: menD
gene_biotype: protein_coding
description:
  2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase/2-oxoglutarate decarboxylase (menD); Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).


ensembl_gene_id: HI_0285
symbol: menF
gene_biotype: protein_coding
description:
  Menaquinone-specific isochorismate synthase (menF); Catalyzes the conversion of chorismate to isochorismate.


ensembl_gene_id: HI_0287
symbol: mtr
gene_biotype: protein_coding
description:
  Tryptophan-specific transport protein (mtr); Involved in transporting tryptophan across the cytoplasmic membrane; Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily.


ensembl_gene_id: HI_0288
symbol: sdaA
gene_biotype: protein_coding
description:
  L-serine deaminase (sdaA); Similar to GB:M28695 SP:P16095 PID:290464 GB:U00096 PID:1736451 percent identity: 68.79; identified by sequence similarity; putative.


ensembl_gene_id: HI_0289
symbol: sdaC
gene_biotype: protein_coding
description:
  Serine transporter (sdaC); Involved in the import of serine into the cell. Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily.


ensembl_gene_id: HI_0290
symbol: HI_0290
gene_biotype: protein_coding
description:
  Potassium/copper-transporting ATPase, putative; Similar to GB:AL009126 percent identity: 39.57; identified by sequence similarity; putative; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.


ensembl_gene_id: HI_0292
symbol: HI_0292
gene_biotype: protein_coding
description:
  Mercuric ion scavenger protein (merP); Similar to GB:X73112 PID:483769 SP:Q51770 percent identity: 32.84; identified by sequence similarity; putative.


ensembl_gene_id: HI_0293
symbol: HI_0293
gene_biotype: protein_coding
description:
  Transcriptional regulator, merR family, putative; Could be a copper-dependent transcriptional activator of the ATPase HI_0290.


ensembl_gene_id: HI_0294
symbol: metJ
gene_biotype: protein_coding
description:
  Met repressor (metJ); This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis; Belongs to the MetJ family.


ensembl_gene_id: HI_0295
symbol: rho
gene_biotype: protein_coding
description:
  Transcription termination factor (rho); Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template.


ensembl_gene_id: HI_0296
symbol: hofD
gene_biotype: protein_coding
description:
  Type 4 prepilin-like protein specific leader peptidase (hopD); Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue.


ensembl_gene_id: HI_0297
symbol: hofC
gene_biotype: protein_coding
description:
  Protein transport protein; Similar to GB:M32066 SP:P22609 PID:151066 percent identity: 29.18; identified by sequence similarity; putative.


ensembl_gene_id: HI_0298
symbol: hofB
gene_biotype: protein_coding
description:
  Protein transport protein; Similar to GB:M32066 SP:P22608 GB:S43866 PID:151065 percent identity: 41.16; identified by sequence similarity; putative; Belongs to the GSP E family.


ensembl_gene_id: HI_0299
symbol: ppdD
gene_biotype: protein_coding
description:
  Prepilin peptidase dependent protein D; Similar to GB:D26562 SP:P36647 GB:L28105 PID:473777 PID:456042 percent identity: 41.54; identified by sequence similarity; putative.


ensembl_gene_id: HI_0300
symbol: ampD
gene_biotype: protein_coding
description:
  ampD signalling protein (ampD); Involved in cell wall peptidoglycan recycling. Specifically cleaves the amide bond between the lactyl group of N-acetylmuramic acid and the alpha-amino group of the L-alanine in degradation products containing an anhydro N-acetylmuramyl moiety. Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.


ensembl_gene_id: HI_0302
symbol: lnt
gene_biotype: protein_coding
description:
  Apolipoprotein N-acyltransferase (cutE); Catalyzes the phospholipid dependent N-acylation of the N- terminal cysteine of apolipoprotein, the last step in lipoprotein maturation; Belongs to the CN hydrolase family. Apolipoprotein N- acyltransferase subfamily.


ensembl_gene_id: HI_0303
symbol: rsmE
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity).


ensembl_gene_id: HI_0304
symbol: HI_0304
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to PID:882477 SP:P52049 GB:U00096 PID:1789317 percent identity: 44.57; identified by sequence similarity; putative; Belongs to the UPF0301 (AlgH) family.


ensembl_gene_id: HI_0305
symbol: HI_0305
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.


ensembl_gene_id: HI_0307
symbol: proC
gene_biotype: protein_coding
description:
  Pyrroline-5-carboxylate reductase (proC); Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.


ensembl_gene_id: HI_0308
symbol: hcaT
gene_biotype: protein_coding
description:
  Conserved hypothetical transmembrane protein; Probable permease involved in the uptake of 3-phenylpropionic acid; Belongs to the major facilitator superfamily. Phenyl propionate permease (PPP) (TC 2.A.1.27) family.


ensembl_gene_id: HI_0309
symbol: xerD
gene_biotype: protein_coding
description:
  Integrase/recombinase (xerD); Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.


ensembl_gene_id: HI_0312
symbol: ruvB
gene_biotype: protein_coding
description:
  Holliday junction DNA helicase (ruvB); The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.


ensembl_gene_id: HI_0313
symbol: ruvA
gene_biotype: protein_coding
description:
  Holliday junction DNA helicase (ruvA); The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.


ensembl_gene_id: HI_0314
symbol: ruvC
gene_biotype: protein_coding
description:
  Crossover junction endodeoxyribonuclease (ruvC); Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity).


ensembl_gene_id: HI_0315
symbol: HI_0315
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:D10165 SP:P24237 PID:216652 PID:42173 GB:U00096 percent identity: 75.20; identified by sequence similarity; putative.


ensembl_gene_id: HI_0316
symbol: nudB
gene_biotype: protein_coding
description:
  datP pyrophosphohydrolase (ntpA); Catalyzes the hydrolysis of dihydroneopterin triphosphate to dihydroneopterin monophosphate and pyrophosphate. Required for efficient folate biosynthesis. Can also hydrolyze nucleoside triphosphates with a preference for dATP.


ensembl_gene_id: HI_0317
symbol: aspS
gene_biotype: protein_coding
description:
  aspartyl-tRNA synthetase (aspS); Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp- AMP and then transferred to the acceptor end of tRNA(Asp). Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.


ensembl_gene_id: HI_0318
symbol: HI_0318
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to SP:P54158 PID:1256620 GB:AL009126 percent identity: 23.78; identified by sequence similarity; putative.


ensembl_gene_id: HI_0319
symbol: cmoA
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM).


ensembl_gene_id: HI_0321
symbol: vapB1
gene_biotype: protein_coding
description:
  Virulence associated protein B (vapB); Antitoxin component of a type II toxin-antitoxin (TA) system. Neutralizes the effect of toxin VapC1 (By similarity).


ensembl_gene_id: HI_0322
symbol: vapC1
gene_biotype: protein_coding
description:
  Virulence associated protein C, putative; Toxic component of a type II toxin-antitoxin (TA) system. Acts as an RNase, its toxic effect is neutralized by VapB1 antitoxin (By similarity); Belongs to the PINc/VapC protein family.


ensembl_gene_id: HI_0323
symbol: gloA
gene_biotype: protein_coding
description:
  Lactoylglutathione lyase (gloA); Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.


ensembl_gene_id: HI_0324
symbol: rnt
gene_biotype: protein_coding
description:
  Ribonuclease T (rnt); Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis.


ensembl_gene_id: HI_0325
symbol: HI_0325
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:AL009126 percent identity: 52.27; identified by sequence similarity; putative.


ensembl_gene_id: HI_0328
symbol: efp
gene_biotype: protein_coding
description:
  Elongation factor P (efp); Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation; Belongs to the elongation factor P family.


ensembl_gene_id: HI_0329
symbol: epmB
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; With EpmA is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF- P) on 'Lys-34'. EpmB appears to act before EpmA. Displays lysine 2,3- aminomutase activity, producing (R)-beta-lysine from (S)-alpha-lysine (L-lysine) (By similarity); Belongs to the radical SAM superfamily. KamA family.


ensembl_gene_id: HI_0330
symbol: oapA
gene_biotype: protein_coding
description:
  Opacity associated protein (oapA); Cell envelope protein involved in phase variation, confers opaque colony phenotype; Belongs to the OapA family.


ensembl_gene_id: HI_0331
symbol: oapB
gene_biotype: protein_coding
description:
  Opacity associated protein (oapB); Similar to GB:L42023 SP:P44416 PID:1003553 PID:1222256 PID:595943 percent identity: 100.00; identified by sequence similarity; putative.


ensembl_gene_id: HI_0333
symbol: rlmD
gene_biotype: protein_coding
description:
  RNA methyltransferase, putative; Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily.


ensembl_gene_id: HI_0334
symbol: relA
gene_biotype: protein_coding
description:
  GTP pyrophosphokinase (relA); In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp (By similarity).


ensembl_gene_id: HI_0335
symbol: dgkA
gene_biotype: protein_coding
description:
  Diacylglycerol kinase (dgkA); Recycling of diacylglycerol produced during the turnover of membrane phospholipid.


ensembl_gene_id: HI_0336
symbol: mog
gene_biotype: protein_coding
description:
  Molybdopeterin biosynthesis protein (mog); Catalyzes the adenylation of molybdopterin as part of the biosynthesis of the molybdenum-cofactor.


ensembl_gene_id: HI_0337
symbol: glnB
gene_biotype: protein_coding
description:
  Nitrogen regulatory protein P-II (glnB); P-II indirectly controls the transcription of the glutamine synthetase gene (GlnA). P-II prevents NR-II-catalyzed conversion of NR- I to NR-I-phosphate, the transcriptional activator of GlnA. When P-II is uridylylated to P-II-UMP, these events are reversed. When the ratio of Gln to 2-ketoglutarate decreases, P-II is uridylylated to P-II-UMP, which causes the deadenylation of glutamine synthetase by GlnE, so activating the enzyme (By similarity).


ensembl_gene_id: HI_0338
symbol: HI_0338
gene_biotype: protein_coding
description:
  Conserved hypothetical transmembrane protein; Similar to GB:U00096 PID:1787885 percent identity: 42.60; identified by sequence similarity; putative.


ensembl_gene_id: HI_0339
symbol: priA
gene_biotype: protein_coding
description:
  Primosomal protein N' (priA); Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily.


ensembl_gene_id: HI_0340
symbol: trmB
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.


ensembl_gene_id: HI_0341
symbol: HI_0341
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to SP:P38521 PID:882488 GB:U00096 PID:1789329 percent identity: 55.65; identified by sequence similarity; putative; To E.coli YggL.


ensembl_gene_id: HI_0342
symbol: napF
gene_biotype: protein_coding
description:
  Ferredoxin-type protein (napF); Could be involved in the maturation of NapA, the catalytic subunit of the periplasmic nitrate reductase, before its export into the periplasm; Belongs to the NapF family.


ensembl_gene_id: HI_0343
symbol: napD
gene_biotype: protein_coding
description:
  napD protein (napD); Chaperone for NapA, the catalytic subunit of the periplasmic nitrate reductase. It binds directly and specifically to the twin- arginine signal peptide of NapA, preventing premature interaction with the Tat translocase and premature export.


ensembl_gene_id: HI_0345
symbol: napG
gene_biotype: protein_coding
description:
  Ferredoxin-type protein (napG); Required for electron transfer from ubiquinol, via NapC, to the periplasmic nitrate reductase NapAB complex.


ensembl_gene_id: HI_0346
symbol: napH
gene_biotype: protein_coding
description:
  Ferredoxin-type protein (napH); Required for electron transfer from ubiquinol, via NapC, to the periplasmic nitrate reductase NapAB complex.


ensembl_gene_id: HI_0347
symbol: napB
gene_biotype: protein_coding
description:
  Periplasmic nitrate reductase (napB); Electron transfer subunit of the periplasmic nitrate reductase complex NapAB. Receives electrons from the membrane-anchored tetraheme c-type NapC protein and transfers these to NapA subunit, thus allowing electron flow between membrane and periplasm. Essential for periplasmic nitrate reduction with nitrate as the terminal electron acceptor; Belongs to the NapB family.


ensembl_gene_id: HI_0349
symbol: adk
gene_biotype: protein_coding
description:
  Adenylate kinase (adk); Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity). It may be linked to the biosynthesis of lipopolysaccharide surface molecules, which are important for the pathogenesis of H.influenzae. Belongs to the adenylate kinase family.


ensembl_gene_id: HI_0350
symbol: HI_0350
gene_biotype: protein_coding
description:
  Permease, putative; Similar to GB:U00096 SP:P36670 PID:1773117 PID:1786636 PID:563855 percent identity: 38.06; identified by sequence similarity; putative.


ensembl_gene_id: HI_0351
symbol: galE
gene_biotype: protein_coding
description:
  UDP-glucose 4-epimerase (galE); Involved in the metabolism of galactose. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD. By controlling the internal galactose concentration, it may be linked to the biosynthesis of lipopolysaccharide surface molecules, which are important for the pathogenesis of H.influenzae.


ensembl_gene_id: HI_0352
symbol: HI_0352
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to SP:P24324 GB:X57315 PID:43588 percent identity: 98.23; identified by sequence similarity; putative.


ensembl_gene_id: HI_0354
symbol: HI_0354
gene_biotype: protein_coding
description:
  ABC transporter, ATP-binding protein; Similar to PID:1184189 GB:U00096 SP:Q47538 PID:1384059 PID:1657561 percent identity: 41.09; identified by sequence similarity; putative; Belongs to the ABC transporter superfamily.


ensembl_gene_id: HI_0355
symbol: HI_0355
gene_biotype: protein_coding
description:
  ABC transporter, permease protein; Probably part of a binding-protein-dependent transport system. Probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.


ensembl_gene_id: HI_0358
symbol: HI_0358
gene_biotype: protein_coding
description:
  Transcriptional activator, putative; Similar to GB:AE000511 PID:2314455 percent identity: 34.29; identified by sequence similarity; putative; Belongs to the thiaminase-2 family.


ensembl_gene_id: HI_0359
symbol: HI_0359
gene_biotype: protein_coding
description:
  Iron (chelated) ABC transporter, permease protein (yfeD); Part of an ATP-driven transport system HI_0359/HI_0360/HI_0361/HI_0362 for iron; Belongs to the ABC-3 integral membrane protein family.


ensembl_gene_id: HI_0360
symbol: HI_0360
gene_biotype: protein_coding
description:
  Iron (chelated) ABC transporter, permease protein (yfeC); Part of an ATP-driven transport system HI_0359/HI_0360/HI_0361/HI_0362 for iron; Belongs to the ABC-3 integral membrane protein family.


ensembl_gene_id: HI_0361
symbol: HI_0361
gene_biotype: protein_coding
description:
  Iron (chelated) transporter, ATP-binding protein (yfeB); Part of an ATP-driven transport system HI_0359/HI_0360/HI_0361/HI_0362 for iron. Probably responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily.


ensembl_gene_id: HI_0362
symbol: HI_0362
gene_biotype: protein_coding
description:
  Iron (chelated) ABC transporter, periplasmic-binding protein (yfeA); Part of an ATP-driven transport system HI_0359/HI_0360/HI_0361/HI_0362 for iron. Metal-binding component (Potential); Belongs to the bacterial solute-binding protein 9 family.


ensembl_gene_id: HI_0364
symbol: pbpG
gene_biotype: protein_coding
description:
  Penicillin-binding protein 7, putative; Cell wall formation. May play a specialized role in remodeling the cell wall. Specifically hydrolyzes the DD- diaminopimelate-alanine bonds in high-molecular-mass murein sacculi (By similarity); Belongs to the peptidase S11 family.


ensembl_gene_id: HI_0365
symbol: rlmN
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity; Belongs to the radical SAM superfamily. RlmN family.


ensembl_gene_id: HI_0366
symbol: HI_0366
gene_biotype: protein_coding
description:
  Fimbrial biogenesis and twitching motility protein, putative; Similar to PID:1162960 percent identity: 33.59; identified by sequence similarity; putative.


ensembl_gene_id: HI_0367
symbol: HI_0367
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to SP:P27434 GB:D21149 GB:U02965 GB:X64451 PID:41541 percent identity: 26.33; identified by sequence similarity; putative.


ensembl_gene_id: HI_0368
symbol: ispG
gene_biotype: protein_coding
description:
  gcpE protein (gcpE); Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family.


ensembl_gene_id: HI_0369
symbol: hisS
gene_biotype: protein_coding
description:
  histidyl-tRNA synthetase (hisS); Similar to GB:M11843 SP:P04804 PID:146372 GB:U00096 PID:1788861 percent identity: 66.82; identified by sequence similarity; putative.


ensembl_gene_id: HI_0370
symbol: HI_0370
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:U00096 PID:1788860 percent identity: 36.50; identified by sequence similarity; putative.


ensembl_gene_id: HI_0372
symbol: fdx
gene_biotype: protein_coding
description:
  Ferredoxin (fdx-1); Ferredoxin are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions; Belongs to the adrenodoxin/putidaredoxin family.


ensembl_gene_id: HI_0373
symbol: hscA
gene_biotype: protein_coding
description:
  Heat shock protein (hscA); Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB (By similarity).


ensembl_gene_id: HI_0374
symbol: HI_0374
gene_biotype: protein_coding
description:
  Predicted coding region HI0374; Hypothetical protein; identified by GeneMark; putative; To E.coli YbfG.


ensembl_gene_id: HI_0375
symbol: hscB
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity); Belongs to the HscB family.


ensembl_gene_id: HI_0376
symbol: iscA
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system (By similarity); Belongs to the HesB/IscA family.


ensembl_gene_id: HI_0377
symbol: iscU
gene_biotype: protein_coding
description:
  iscU protein (iscU); A scaffold on which IscS assembles Fe-S clusters. Subsequently gives the nascent cluster to other proteins. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters (By similarity).


ensembl_gene_id: HI_0378
symbol: iscS
gene_biotype: protein_coding
description:
  nifS protein (nifS); Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.


ensembl_gene_id: HI_0379
symbol: HI_0379
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:U00096 PID:1788880 percent identity: 63.38; identified by sequence similarity; putative.


ensembl_gene_id: HI_0380
symbol: HI_0380
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:U00096 PID:1788881 percent identity: 54.43; identified by sequence similarity; putative; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.


ensembl_gene_id: HI_0381
symbol: pal
gene_biotype: protein_coding
description:
  Peptidoglycan-associated outer membrane lipoprotein (pal); Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.


ensembl_gene_id: HI_0382
symbol: tolB
gene_biotype: protein_coding
description:
  Colicin tolerance protein (tolB); Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.


ensembl_gene_id: HI_0383
symbol: tolA
gene_biotype: protein_coding
description:
  Outer membrane integrity protein (tolA); Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.


ensembl_gene_id: HI_0384
symbol: tolR
gene_biotype: protein_coding
description:
  Colicin transport protein (tolR); Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.


ensembl_gene_id: HI_0385
symbol: tolQ
gene_biotype: protein_coding
description:
  Colicin transport protein (tolQ); Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.


ensembl_gene_id: HI_0386
symbol: ybgC
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Displays acyl-CoA thioesterase activity with short chain aliphatic acyl-CoA thioesters, such as propionyl-CoA and butyryl-CoA. Enzyme activity is relatively low, suggesting that the acyl-CoA thioesters used in the assays are not the physiological substrates. Has no detectable activity with 4-hydroxybenzoyl-CoA, lauroyl-CoA (C12:0), arachidoyl-CoA (C20:0) and arachidonoyl-CoA (C20:4).


ensembl_gene_id: HI_0387
symbol: HI_0387
gene_biotype: protein_coding
description:
  ATP-dependent helicase (dinG); Similar to GB:U00096 PID:1736441 PID:1736447 PID:1788110 percent identity: 61.17; identified by sequence similarity; putative; Belongs to the helicase family. DinG subfamily.


ensembl_gene_id: HI_0388
symbol: tsaB
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaE; this reaction does not require ATP in vitro. TsaB seems to play an indirect role in the t(6)A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD (By similarity); Belongs to the KAE1 / TsaD family. TsaB subfamily.


ensembl_gene_id: HI_0389
symbol: HI_0389
gene_biotype: protein_coding
description:
  Outer membrane protein; Similar to GB:U00039 SP:P37194 GB:L23635 PID:387932 PID:466643 percent identity: 27.33; identified by sequence similarity; putative.


ensembl_gene_id: HI_0390
symbol: rnd
gene_biotype: protein_coding
description:
  Ribonuclease D (rnd); Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides; Belongs to the RNase D family.


ensembl_gene_id: HI_0390.1
symbol: fadD
gene_biotype: protein_coding
description:
  Long chain fatty acid coenzyme A ligase (fadD); Catalyzes the esterification, concomitant with transport, of exogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids; Belongs to the ATP-dependent AMP-binding enzyme family.


ensembl_gene_id: HI_0392
symbol: HI_0392
gene_biotype: protein_coding
description:
  O-antigen acetylase, putative; Similar to GP:1518853 percent identity: 31.46; identified by sequence similarity; putative.


ensembl_gene_id: HI_0393
symbol: ychF
gene_biotype: protein_coding
description:
  Conserved hypothetical GTP-binding protein; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner (By similarity). Does not hydrolyze GTP; Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.


ensembl_gene_id: HI_0394
symbol: pth
gene_biotype: protein_coding
description:
  peptidyl-tRNA hydrolase (pth); The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family.


ensembl_gene_id: HI_0395
symbol: HI_0395
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to PID:1033114 SP:P52119 GB:U00096 PID:1788971 percent identity: 55.32; identified by sequence similarity; putative; Belongs to the UPF0125 (RnfH) family.


ensembl_gene_id: HI_0396
symbol: HI_0396
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Oxygenase that catalyzes the hydroxylation of a ribosomal protein; Belongs to the ROX family.


ensembl_gene_id: HI_0397
symbol: xseA
gene_biotype: protein_coding
description:
  Exodeoxyribonuclease VII, large subunit (xseA); Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family.


ensembl_gene_id: HI_0398
symbol: nudF
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Acts on ADP-mannose and ADP-glucose as well as ADP-ribose. Prevents glycogen biosynthesis. The reaction catalyzed by this enzyme is a limiting step of the gluconeogenic process (By similarity).


ensembl_gene_id: HI_0399
symbol: cpdA
gene_biotype: protein_coding
description:
  lacZ expression regulator (icc); Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. May coordinate responses to nutritional stress, ensuring optimal competence development. Belongs to the cAMP phosphodiesterase class-III family.


ensembl_gene_id: HI_0400
symbol: HI_0400
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:U00096 PID:1788685 percent identity: 42.42; identified by sequence similarity; putative; Belongs to the UPF0381 family.


ensembl_gene_id: HI_0401
symbol: ompP1
gene_biotype: protein_coding
description:
  Long-chain fatty acid transport protein (fadL); Similar to GB:M60607 SP:P10384 GB:Y00552 PID:145910 PID:41372 percent identity: 42.79; identified by sequence similarity; putative.


ensembl_gene_id: HI_0402
symbol: ogt
gene_biotype: protein_coding
description:
  methylated-DNA--protein-cysteine methyltransferase (dat1); Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.


ensembl_gene_id: HI_0403
symbol: mutH
gene_biotype: protein_coding
description:
  DNA mismatch repair protein (mutH); Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair; Belongs to the MutH family.


ensembl_gene_id: HI_0404
symbol: tilS
gene_biotype: protein_coding
description:
  Cell cycle protein (mesJ); Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family.


ensembl_gene_id: HI_0405
symbol: pdxY
gene_biotype: protein_coding
description:
  Pyridoxine kinase, putative; Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP.


ensembl_gene_id: HI_0406
symbol: accA
gene_biotype: protein_coding
description:
  acetyl-CoA carboxylase, carboxyl transferase (accA); Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.


ensembl_gene_id: HI_0407
symbol: znuB
gene_biotype: protein_coding
description:
  Conserved hypothetical integral membrane protein; Involved in the high-affinity zinc uptake transport system. Belongs to the ABC-3 integral membrane protein family.


ensembl_gene_id: HI_0408
symbol: znuC
gene_biotype: protein_coding
description:
  ABC transporter, ATP-binding protein (yebM); Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Zinc importer (TC 3.A.1.15.5) family.


ensembl_gene_id: HI_0409
symbol: HI_0409
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:M77039 SP:P24204 PID:146890 PID:1054957 GB:U00096 percent identity: 49.26; identified by sequence similarity; putative; In the central section; belongs to the OapA family.


ensembl_gene_id: HI_0410
symbol: tyrR
gene_biotype: protein_coding
description:
  Transcriptional regulatory protein (tyrR); Involved in transcriptional regulation of aromatic amino acid biosynthesis and transport.


ensembl_gene_id: HI_0411
symbol: hfq
gene_biotype: protein_coding
description:
  Host factor-I protein (hfq); RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family.


ensembl_gene_id: HI_0412
symbol: rluC
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Responsible for synthesis of pseudouridine from uracil at positions 955, 2504 and 2580 in 23S ribosomal RNA; Belongs to the pseudouridine synthase RluA family.


ensembl_gene_id: HI_0413
symbol: rne
gene_biotype: protein_coding
description:
  Ribonuclease E (rne); Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs. Belongs to the RNase E/G family. RNase E subfamily.


ensembl_gene_id: HI_0414
symbol: HI_0414
gene_biotype: protein_coding
description:
  Predicted coding region HI0414; Hypothetical protein; identified by GeneMark; putative; Belongs to the opacity porin family.


ensembl_gene_id: HI_0415
symbol: thiM
gene_biotype: protein_coding
description:
  Hydroxyethylthiazole kinase; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family.


ensembl_gene_id: HI_0416
symbol: thiD
gene_biotype: protein_coding
description:
  Phosphomethylpyrimidine kinase (thiD); Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P.


ensembl_gene_id: HI_0417
symbol: thiE
gene_biotype: protein_coding
description:
  Thiamin-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.


ensembl_gene_id: HI_0418
symbol: HI_0418
gene_biotype: protein_coding
description:
  Transport protein, putative; Similar to GB:L42023 SP:P44610 PID:1003458 PID:1222206 PID:1204537 percent identity: 60.92; identified by sequence similarity; putative.


ensembl_gene_id: HI_0419
symbol: HI_0419
gene_biotype: protein_coding
description:
  Protease, putative; Similar to GB:U00096 SP:P76403 PID:1736789 PID:1736801 PID:1788397 percent identity: 79.52; identified by sequence similarity; putative; Belongs to the peptidase U32 family.


ensembl_gene_id: HI_0422
symbol: srmB
gene_biotype: protein_coding
description:
  ATP-dependent RNA helicase (srmB); DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit at low temperature. Exhibits RNA-stimulated ATP hydrolysis and RNA unwinding activity; Belongs to the DEAD box helicase family. SrmB subfamily.


ensembl_gene_id: HI_0423
symbol: HI_0423
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC).


ensembl_gene_id: HI_0424
symbol: HI_0424
gene_biotype: protein_coding
description:
  rRNA methylase, putative; Similar to SP:P33635 GB:U00096 PID:1788935 percent identity: 43.03; identified by sequence similarity; putative; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.


ensembl_gene_id: HI_0425
symbol: pssA
gene_biotype: protein_coding
description:
  Phosphatidylserine synthase (pssA); Similar to GB:M58699 SP:P23830 PID:147389 GB:U00096 PID:1788940 percent identity: 50.33; identified by sequence similarity; putative.


ensembl_gene_id: HI_0427
symbol: nhaB
gene_biotype: protein_coding
description:
  Na+/H+ antiporter (nhaB); Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons; Belongs to the NhaB Na(+)/H(+) (TC 2.A.34) antiporter family.


ensembl_gene_id: HI_0428
symbol: dsbB
gene_biotype: protein_coding
description:
  Disulfide bond formation protein B (dsbB); Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein; Belongs to the DsbB family.


ensembl_gene_id: HI_0429
symbol: glmS
gene_biotype: protein_coding
description:
  Glucosamine--fructose-6-phosphate aminotransferase (glmS); Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.


ensembl_gene_id: HI_0430
symbol: hup
gene_biotype: protein_coding
description:
  DNA-binding protein HU-alpha (hupA); Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions; Belongs to the bacterial histone-like protein family.


ensembl_gene_id: HI_0431
symbol: HI_0431
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to SP:P32680 PID:396338 GB:U00096 PID:1790432 percent identity: 54.59; identified by sequence similarity; putative; To E.coli YjaG.


ensembl_gene_id: HI_0432
symbol: nudC
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to SP:P32664 PID:396335 GB:U00096 PID:1790429 percent identity: 47.29; identified by sequence similarity; putative.


ensembl_gene_id: HI_0433
symbol: nfuA
gene_biotype: protein_coding
description:
  orfG protein; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins.


ensembl_gene_id: HI_0435
symbol: comE
gene_biotype: protein_coding
description:
  Competence protein E (comE); Involved in transformation (competence for DNA uptake); Belongs to the bacterial secretin family. PilQ subfamily.


ensembl_gene_id: HI_0440
symbol: mrcA
gene_biotype: protein_coding
description:
  Penicillin-binding protein 1A (ponA); Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits).


ensembl_gene_id: HI_0442
symbol: HI_0442
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.


ensembl_gene_id: HI_0443
symbol: recR
gene_biotype: protein_coding
description:
  Recombination protein (recR); May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.


ensembl_gene_id: HI_0444
symbol: topB
gene_biotype: protein_coding
description:
  DNA topoisomerase III (topB); Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing [...]


ensembl_gene_id: HI_0445
symbol: secG
gene_biotype: protein_coding
description:
  Protein-export membrane protein (secG); Involved in protein export. Participates in an early event of protein translocation (By similarity); Belongs to the SecG family.


ensembl_gene_id: HI_0446
symbol: fruA
gene_biotype: protein_coding
description:
  PTS system, fructose-specific IIBC component (fruA); The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FruAB PTS system is involved in fructose transport.


ensembl_gene_id: HI_0447
symbol: fruK
gene_biotype: protein_coding
description:
  1-phosphofructokinase (fruK); Similar to SP:P23539 GB:X53948 PID:405894 PID:41487 GB:U00096 percent identity: 55.41; identified by sequence similarity; putative; Belongs to the carbohydrate kinase PfkB family.


ensembl_gene_id: HI_0448
symbol: fruB
gene_biotype: protein_coding
description:
  PTS system, fructose-specific IIA/FPr component (fruB); The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FruAB PTS system is involved in fructose transport.


ensembl_gene_id: HI_0450
symbol: vapD
gene_biotype: protein_coding
description:
  Virulence associated protein D (vapD); Cleaves ssRNA, mostly between U:A; Belongs to the VapD ribonuclease family.


ensembl_gene_id: HI_0451
symbol: HI_0451
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to PID:1196479 percent identity: 56.67; identified by sequence similarity; putative.


ensembl_gene_id: HI_0452
symbol: HI_0452
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:U14003 SP:P39319 PID:537059 GB:U00096 PID:1790664 percent identity: 52.57; identified by sequence similarity; putative.


ensembl_gene_id: HI_0453
symbol: HI_0453
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:AE000511 PID:2313105 percent identity: 41.52; identified by sequence similarity; putative.


ensembl_gene_id: HI_0454
symbol: HI_0454
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to SP:P37346 GB:U00096 PID:1787342 percent identity: 59.92; identified by sequence similarity; putative.


ensembl_gene_id: HI_0455
symbol: holB
gene_biotype: protein_coding
description:
  DNA polymerase III, delta' subunit (holB); DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity).


ensembl_gene_id: HI_0456
symbol: tmk
gene_biotype: protein_coding
description:
  Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.


ensembl_gene_id: HI_0457
symbol: mltG
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. Belongs to the transglycosylase MltG family.


ensembl_gene_id: HI_0458
symbol: surA
gene_biotype: protein_coding
description:
  Stationary phase survival protein SurA, putative; Chaperone involved in the folding of extracytoplasmic proteins.


ensembl_gene_id: HI_0459
symbol: pyrR
gene_biotype: protein_coding
description:
  Pyrimidine operon regulatory protein (pyrR); Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines.


ensembl_gene_id: HI_0460
symbol: mazG
gene_biotype: protein_coding
description:
  mazG protein (mazG); Involved in the regulation of bacterial cell survival under conditions of nutritional stress. Regulates the MazE-MazF toxin- antitoxin (TA) system that mediates programmed cell death (PCD). This is achieved by lowering the cellular concentration of (p)ppGpp produced by RelA under amino acid starvation, thus protecting the cell from the toxicity of MazF. Reduction of (p)ppGpp can be achieved by direct degradation of (p)ppGpp or by degradation of NTPs, which are substrates for (p)ppGpp synthesis by RelA (By similarity); Belongs to the nucleoside triphosphate pyrophos [...]


ensembl_gene_id: HI_0461
symbol: HI_0461
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to SP:P32181 percent identity: 35.64; identified by sequence similarity; putative.


ensembl_gene_id: HI_0462
symbol: lon
gene_biotype: protein_coding
description:
  ATP-dependent proteinase (lon); ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.


ensembl_gene_id: HI_0463
symbol: hemW
gene_biotype: protein_coding
description:
  Oxygen-independent coproporphyrinogen III oxidase, putative; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently (By similarity). Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L- methionine (By similarity).


ensembl_gene_id: HI_0464
symbol: rpiA
gene_biotype: protein_coding
description:
  Ribose 5-phosphate isomerase A (rpiA); Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.


ensembl_gene_id: HI_0465
symbol: serA
gene_biotype: protein_coding
description:
  D-3-phosphoglycerate dehydrogenase (serA); Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.


ensembl_gene_id: HI_0466
symbol: HI_0466
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to PID:887848 GB:U00096 SP:P39179 PID:1789265 percent identity: 40.36; identified by sequence similarity; putative; To E.coli YgfZ (UP14) and B.aphidicola (subsp. Acyrthosiphon pisum) BU435.


ensembl_gene_id: HI_0467
symbol: HI_0467
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:L10328 SP:P23839 GB:X14235 PID:290494 PID:42721 percent identity: 64.81; identified by sequence similarity; putative; Belongs to the UPF0701 family.


ensembl_gene_id: HI_0468
symbol: hisG
gene_biotype: protein_coding
description:
  ATP phosphoribosyltransferase (hisG); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity); Belongs to the ATP phosphoribosyltransferase family. Long subfamily.


ensembl_gene_id: HI_0469
symbol: hisD
gene_biotype: protein_coding
description:
  Histidinol dehydrogenase (hisD); Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.


ensembl_gene_id: HI_0470
symbol: hisC1
gene_biotype: protein_coding
description:
  Histidinol-phosphate aminotransferase (hisC); Similar to SP:P06986 GB:U02071 GB:X03416 PID:41695 PID:41710 percent identity: 60.40; identified by sequence similarity; putative; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.


ensembl_gene_id: HI_0471
symbol: hisB
gene_biotype: protein_coding
description:
  Imidazoleglycerol-phosphate dehydratase / histidinol-phosphatase (hisB); Similar to SP:P06987 GB:X03416 PID:41696 PID:41711 GB:U00096 percent identity: 64.97; identified by sequence similarity; putative; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family.


ensembl_gene_id: HI_0472
symbol: hisH
gene_biotype: protein_coding
description:
  Amidotransferase (hisH); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity).


ensembl_gene_id: HI_0473
symbol: hisA
gene_biotype: protein_coding
description:
  Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA); Similar to SP:P10371 PID:41713 GB:U00096 PID:1736702 PID:1736711 percent identity: 62.86; identified by sequence similarity; putative.


ensembl_gene_id: HI_0474
symbol: hisF
gene_biotype: protein_coding
description:
  hisF cyclase (hisF); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity).


ensembl_gene_id: HI_0475
symbol: hisI
gene_biotype: protein_coding
description:
  phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP pyrophosphohydrolase (hisIE); Similar to SP:P06989 GB:D43637 GB:U02072 GB:X03974 PID:41700 percent identity: 61.22; identified by sequence similarity; putative; In the C-terminal section; belongs to the PRA-PH family.


ensembl_gene_id: HI_0477
symbol: tyrP-A
gene_biotype: protein_coding
description:
  Tyrosine-specific transport protein (tyrP); Involved in transporting tyrosine across the cytoplasmic membrane; Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily.


ensembl_gene_id: HI_0478
symbol: atpC
gene_biotype: protein_coding
description:
  ATP synthase F1, subunit epsilon (atpC); Produces ATP from ADP in the presence of a proton gradient across the membrane.


ensembl_gene_id: HI_0479
symbol: atpD
gene_biotype: protein_coding
description:
  ATP synthase F1, subunit beta (atpD); Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family.


ensembl_gene_id: HI_0480
symbol: atpG
gene_biotype: protein_coding
description:
  ATP synthase F1, subunit gamma (atpG); Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.


ensembl_gene_id: HI_0481
symbol: atpA
gene_biotype: protein_coding
description:
  ATP synthase F1, subunit alpha (atpA); Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family.


ensembl_gene_id: HI_0482
symbol: atpH
gene_biotype: protein_coding
description:
  ATP synthase F1, subunit delta (atpH); F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family.


ensembl_gene_id: HI_0483
symbol: atpF
gene_biotype: protein_coding
description:
  ATP synthase F0, subunit b (atpF); F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.


ensembl_gene_id: HI_0484
symbol: atpE
gene_biotype: protein_coding
description:
  ATP synthase F0, subunit c (atpE); F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.


ensembl_gene_id: HI_0485
symbol: atpB
gene_biotype: protein_coding
description:
  ATP synthase F0, subunit a (atpB); Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.


ensembl_gene_id: HI_0486
symbol: rsmG
gene_biotype: protein_coding
description:
  Glucose-inhibited division protein (gidB); Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.


ensembl_gene_id: HI_0488
symbol: HI_0488
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:U00096 PID:1789046 percent identity: 42.25; identified by sequence similarity; putative; Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.


ensembl_gene_id: HI_0489
symbol: HI_0489
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:U00096 PID:1789045 percent identity: 50.38; identified by sequence similarity; putative.


ensembl_gene_id: HI_0491
symbol: luxS
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD); Belongs to the LuxS family.


ensembl_gene_id: HI_0493
symbol: HI_0493
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:M29945 PID:1197032 percent identity: 54.00; identified by sequence similarity; putative; Belongs to the transposase IS3/IS150/IS904 family.


ensembl_gene_id: HI_0494
symbol: aphA
gene_biotype: protein_coding
description:
  Acid phosphatase; Dephosphorylates several organic phosphate monoesters. Also has a phosphotransferase activity catalyzing the transfer of low-energy phosphate groups from organic phosphate monoesters to free hydroxyl groups of various organic compounds (By similarity).


ensembl_gene_id: HI_0495
symbol: HI_0495
gene_biotype: protein_coding
description:
  Acid phosphatase; Similar to SP:P32697 GB:X86971 PID:396390 PID:806548 GB:U00096 percent identity: 45.56; identified by sequence similarity; putative.


ensembl_gene_id: HI_0496
symbol: hslV
gene_biotype: protein_coding
description:
  Heat shock protein (hslV); Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.


ensembl_gene_id: HI_0497
symbol: hslU
gene_biotype: protein_coding
description:
  Heat shock protein (hslU); ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.


ensembl_gene_id: HI_0498
symbol: potD-A
gene_biotype: protein_coding
description:
  Spermidine/putrescine ABC transporter, periplasmic-binding protein (potD); Required for the activity of the bacterial periplasmic transport system of putrescine and spermidine. Polyamine binding protein (By similarity); Belongs to the bacterial solute-binding protein PotD/PotF family.


ensembl_gene_id: HI_0499
symbol: ordL
gene_biotype: protein_coding
description:
  Oxidoreductase, putative; Similar to GB:M38433 SP:P37906 PID:1054921 PID:551780 GB:U00096 percent identity: 41.33; identified by sequence similarity; putative.


ensembl_gene_id: HI_0501
symbol: rbsD
gene_biotype: protein_coding
description:
  High affinity ribose transport protein (rbsD); Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.


ensembl_gene_id: HI_0502
symbol: rbsA
gene_biotype: protein_coding
description:
  D-ribose ABC transporter, ATP-binding protein (rbsA); Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Ribose importer (TC 3.A.1.2.1) family.


ensembl_gene_id: HI_0503
symbol: rbsC
gene_biotype: protein_coding
description:
  D-ribose ABC transporter, permease protein (rbsC); Part of the ABC transporter complex RbsABC involved in ribose import. Probably responsible for the translocation of the substrate across the membrane.


ensembl_gene_id: HI_0504
symbol: rbsB
gene_biotype: protein_coding
description:
  D-ribose ABC transporter, periplasmic-binding protein (rbsB); Part of the ABC transporter complex RbsABC involved in ribose import. Binds ribose.


ensembl_gene_id: HI_0505
symbol: rbsK
gene_biotype: protein_coding
description:
  Ribokinase (rbsK); Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.


ensembl_gene_id: HI_0507
symbol: HI_0507
gene_biotype: protein_coding
description:
  Conserved hypothetical transmembrane protein; Similar to PID:882531 SP:P52082 GB:U00096 PID:1789376 percent identity: 37.75; identified by sequence similarity; putative.


ensembl_gene_id: HI_0508
symbol: rraA
gene_biotype: protein_coding
description:
  S-adenosylmethionine:2-demethylmenaquinone methyltransferase (menG); Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome.


ensembl_gene_id: HI_0509
symbol: menA
gene_biotype: protein_coding
description:
  1,4-dihydroxy-2-naphthoate octaprenyltransferase (menA); Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK); Belongs to the MenA family. Type 1 subfamily.


ensembl_gene_id: HI_0510
symbol: trmO
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; S-adenosyl-L-methionine-dependent methyltransferase responsible for the addition of the methyl group in the formation of N6-methyl-N6-threonylcarbamoyladenosine at position 37 (m(6)t(6)A37) of the tRNA anticodon loop of tRNA(Thr)(GGU). The methyl group of m(6)t(6)A37 appears to slightly improve the efficiency of the tRNA decoding ability. Binds to tRNA.


ensembl_gene_id: HI_0511
symbol: tehA
gene_biotype: protein_coding
description:
  Tellurite resistance protein (tehA); Ion channel involved in potassium tellurite resistance. Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.


ensembl_gene_id: HI_0512
symbol: hindIIR
gene_biotype: protein_coding
description:
  Type II restriction endonuclease (HindIIR); Recognizes the double-stranded sequence GTYRAC and cleaves after Y-3.


ensembl_gene_id: HI_0513
symbol: hindIIM
gene_biotype: protein_coding
description:
  Modification methylase (hindIIM); This methylase recognizes the double-stranded sequence GTYRAC, causes specific methylation on A-5 on both strands, and protects the DNA from cleavage by the HindII endonuclease; Belongs to the N(4)/N(6)-methyltransferase family.


ensembl_gene_id: HI_0514
symbol: rpoC
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerase, beta' chain (rpoC); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.


ensembl_gene_id: HI_0515
symbol: rpoB
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerase, beta chain (rpoB); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.


ensembl_gene_id: HI_0516
symbol: rplA
gene_biotype: protein_coding
description:
  Ribosomal protein L1 (rpL1); Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.


ensembl_gene_id: HI_0517
symbol: rplK
gene_biotype: protein_coding
description:
  Ribosomal protein L11 (rpL11); Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.


ensembl_gene_id: HI_0518
symbol: deoD
gene_biotype: protein_coding
description:
  Purine-nucleoside phosphorylase (deoD); Similar to PID:1732037 percent identity: 88.19; identified by sequence similarity; putative.


ensembl_gene_id: HI_0519
symbol: HI_0519
gene_biotype: protein_coding
description:
  Transport protein, putative; Similar to GB:AE000511 PID:2314337 percent identity: 57.49; identified by sequence similarity; putative.


ensembl_gene_id: HI_0520
symbol: HI_0520
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:U14003 SP:P39409 PID:537219 GB:U00096 PID:1790839 percent identity: 36.27; identified by sequence similarity; putative.


ensembl_gene_id: HI_0521
symbol: HI_0521
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:U14003 SP:P37342 PID:537220 GB:U00096 PID:1790840 percent identity: 40.88; identified by sequence similarity; putative; To E.coli YjjI.


ensembl_gene_id: HI_0522
symbol: HI_0522
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:D26185 SP:P37505 PID:467358 GB:AL009126 percent identity: 31.02; identified by sequence similarity; putative.


ensembl_gene_id: HI_0523
symbol: HI_0523
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:AE000511 PID:2314449 percent identity: 36.28; identified by sequence similarity; putative; Belongs to the glycosyltransferase 9 family.


ensembl_gene_id: HI_0524
symbol: fba
gene_biotype: protein_coding
description:
  Fructose-bisphosphate aldolase (fba); Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.


ensembl_gene_id: HI_0525
symbol: pgk
gene_biotype: protein_coding
description:
  Phosphoglycerate kinase (pgk); Similar to SP:P11665 PID:41422 PID:882455 GB:U00096 PID:1789294 percent identity: 81.14; identified by sequence similarity; putative; Belongs to the phosphoglycerate kinase family.


ensembl_gene_id: HI_0526
symbol: HI_0526
gene_biotype: protein_coding
description:
  Predicted coding region HI0526; Hypothetical protein; identified by GeneMark; putative; Belongs to the RNase T2 family.


ensembl_gene_id: HI_0527
symbol: HI_0527
gene_biotype: protein_coding
description:
  Ferredoxin (fdx-2); Similar to SP:P00208 percent identity: 59.49; identified by sequence similarity; putative.


ensembl_gene_id: HI_0529
symbol: tdk
gene_biotype: protein_coding
description:
  Thymidine kinase (tdk); Similar to SP:P23331 GB:X51523 GB:X53733 GB:X67326 PID:43047 percent identity: 68.62; identified by sequence similarity; putative.


ensembl_gene_id: HI_0530
symbol: tsaD
gene_biotype: protein_coding
description:
  O-sialoglycoprotein endopeptidase (gcp); Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family.


ensembl_gene_id: HI_0531
symbol: rpsU
gene_biotype: protein_coding
description:
  Ribosomal protein S21 (rpS21); Similar to GB:J01687 SP:P02379 GB:V00346 PID:147754 PID:42868 percent identity: 83.10; identified by sequence similarity; putative; Belongs to the bacterial ribosomal protein bS21 family.


ensembl_gene_id: HI_0532
symbol: dnaG
gene_biotype: protein_coding
description:
  DNA primase (dnaG); RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.


ensembl_gene_id: HI_0533
symbol: rpoD
gene_biotype: protein_coding
description:
  RNA polymerase sigma-70 factor (rpoD); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.


ensembl_gene_id: HI_0534
symbol: aspA
gene_biotype: protein_coding
description:
  Aspartate ammonia-lyase (aspA); Similar to GB:U14003 SP:P04422 GB:L20944 GB:X02307 GB:X04066 percent identity: 77.85; identified by sequence similarity; putative; Belongs to the class-II fumarase/aspartase family. Aspartase subfamily.


ensembl_gene_id: HI_0535
symbol: ureD
gene_biotype: protein_coding
description:
  Urease accessory protein (ureH); Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.


ensembl_gene_id: HI_0536
symbol: ureG
gene_biotype: protein_coding
description:
  Urease accessory protein (ureG); Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.


ensembl_gene_id: HI_0537
symbol: ureF
gene_biotype: protein_coding
description:
  Urease accessory protein (ureF); Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.


ensembl_gene_id: HI_0538
symbol: ureE
gene_biotype: protein_coding
description:
  Urease accessory protein (ureE); Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly. Belongs to the UreE family.


ensembl_gene_id: HI_0539
symbol: ureC
gene_biotype: protein_coding
description:
  Urease, alpha subunit (ureC); Similar to SP:Q07397 PID:216362 percent identity: 67.25; identified by sequence similarity; putative; Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.


ensembl_gene_id: HI_0540
symbol: ureB
gene_biotype: protein_coding
description:
  Urease, beta subunit (ureB); Similar to GB:L03307 SP:Q03283 PID:148153 percent identity: 61.76; identified by sequence similarity; putative; Belongs to the urease beta subunit family.


ensembl_gene_id: HI_0541
symbol: ureA
gene_biotype: protein_coding
description:
  Urease, gamma subunit (ureA); Similar to SP:Q07399 PID:216360 percent identity: 67.00; identified by sequence similarity; putative; Belongs to the urease gamma subunit family.


ensembl_gene_id: HI_0542
symbol: groS
gene_biotype: protein_coding
description:
  Chaperonin (groES); Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.


ensembl_gene_id: HI_0543
symbol: groL
gene_biotype: protein_coding
description:
  Heat shock protein (groEL); Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.


ensembl_gene_id: HI_0545
symbol: rpsR
gene_biotype: protein_coding
description:
  Ribosomal protein S18 (rpS18); Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family.


ensembl_gene_id: HI_0546
symbol: priB
gene_biotype: protein_coding
description:
  Primosomal replication protein N (priB); Binds single-stranded DNA at the primosome assembly site (PAS); Belongs to the PriB family.


ensembl_gene_id: HI_0547
symbol: rpsF
gene_biotype: protein_coding
description:
  Ribosomal protein S6 (rpS6); Binds together with S18 to 16S ribosomal RNA; Belongs to the bacterial ribosomal protein bS6 family.


ensembl_gene_id: HI_0548
symbol: infA
gene_biotype: protein_coding
description:
  Translation initiation factor 1 (infA); One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.


ensembl_gene_id: HI_0549
symbol: rsmA
gene_biotype: protein_coding
description:
  Dimethyladenosine transferase (ksgA); Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.


ensembl_gene_id: HI_0550
symbol: lex1
gene_biotype: protein_coding
description:
  Lipooligosaccharide biosynthesis protein; Involved in extracellular lipooligosaccharide (LOS) biosynthesis and virulence expression. Involved in the synthesis of the oligosaccharide moiety of the LOS molecule by adding GalNAc; Belongs to the glycosyltransferase 25 family.


ensembl_gene_id: HI_0551
symbol: apaH
gene_biotype: protein_coding
description:
  Diadenosine-tetraphosphatase (apaH); Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP; Belongs to the Ap4A hydrolase family.


ensembl_gene_id: HI_0553
symbol: gnd
gene_biotype: protein_coding
description:
  6-phosphogluconate dehydrogenase, decarboxylating (gnd); Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.


ensembl_gene_id: HI_0555
symbol: HI_0555
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:M87483 SP:Q02009 PID:551879 percent identity: 40.21; identified by sequence similarity; putative.


ensembl_gene_id: HI_0558
symbol: zwf
gene_biotype: protein_coding
description:
  Glucose-6-phosphate 1-dehydrogenase (zwf); Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone.


ensembl_gene_id: HI_0559
symbol: cysQ
gene_biotype: protein_coding
description:
  Sulfite synthesis pathway protein (cysQ); Converts adenosine-3',5'-bisphosphate (PAP) to AMP. Belongs to the inositol monophosphatase superfamily. CysQ family.


ensembl_gene_id: HI_0561
symbol: HI_0561
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GP:1655665 percent identity: 43.93; identified by sequence similarity; putative.


ensembl_gene_id: HI_0562
symbol: hslR
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Involved in the recycling of free 50S ribosomal subunits that still carry a nascent chain. Binds RNA more specifically than DNA. Binds with very high affinity to the free 50S ribosomal subunit. Does not bind it when it is part of the 70S ribosome (By similarity).


ensembl_gene_id: HI_0564
symbol: asnA
gene_biotype: protein_coding
description:
  Aspartate--ammonia ligase (asnA); Similar to GB:L10328 SP:P00963 GB:J01657 GB:K00826 GB:M10679 percent identity: 63.33; identified by sequence similarity; putative.


ensembl_gene_id: HI_0565
symbol: gph
gene_biotype: protein_coding
description:
  Phosphoglycolate phosphatase (gph); Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.


ensembl_gene_id: HI_0566
symbol: rpe
gene_biotype: protein_coding
description:
  Ribulose-phosphate 3-epimerase (dod); Catalyzes the reversible epimerization of D-ribulose 5- phosphate to D-xylulose 5-phosphate; Belongs to the ribulose-phosphate 3-epimerase family.


ensembl_gene_id: HI_0567
symbol: gyrB
gene_biotype: protein_coding
description:
  DNA gyrase, subunit B (gyrB); A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.


ensembl_gene_id: HI_0568
symbol: HI_0568
gene_biotype: protein_coding
description:
  Transcription accessory protein (tex); Similar to SP:Q45388 PID:1477402 percent identity: 58.05; identified by sequence similarity; putative.


ensembl_gene_id: HI_0569
symbol: greB
gene_biotype: protein_coding
description:
  Transcription elongation factor (greB); Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length.


ensembl_gene_id: HI_0570
symbol: HI_0570
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:U00096 PID:1790401 percent identity: 65.70; identified by sequence similarity; putative.


ensembl_gene_id: HI_0571
symbol: oxyR
gene_biotype: protein_coding
description:
  Hydrogen peroxide-inducible genes activator (oxyR); Required for the induction of a regulon of hydrogen peroxide inducible genes such as catalase and glutathione-reductase.


ensembl_gene_id: HI_0572
symbol: PGdx
gene_biotype: protein_coding
description:
  Membrane protein; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; In the C-terminal section; belongs to the glutaredoxin family.


ensembl_gene_id: HI_0573
symbol: slyX
gene_biotype: protein_coding
description:
  slyX protein (slyX); Similar to GB:L13261 SP:P30857 PID:290468 PID:606282 GB:U00096 percent identity: 50.75; identified by sequence similarity; putative; Belongs to the SlyX family.


ensembl_gene_id: HI_0574
symbol: HI_0574
gene_biotype: protein_coding
description:
  FkbP-type peptidyl-prolyl cis-trans isomerase (fkpA); PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity); Belongs to the FKBP-type PPIase family.


ensembl_gene_id: HI_0575
symbol: HI_0575
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to SP:P45533 PID:606280 GB:U00096 PID:1789744 percent identity: 67.42; identified by sequence similarity; putative; To E.coli YheO.


ensembl_gene_id: HI_0576
symbol: tusD
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Could be part of a sulfur-relay system; Belongs to the DsrE/TusD family.


ensembl_gene_id: HI_0576.1
symbol: tusC
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Could be part of a sulfur-relay system; Belongs to the DsrF/TusC family.


ensembl_gene_id: HI_0578
symbol: tufA
gene_biotype: protein_coding
description:
  Elongation factor Tu (tufA); This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis.


ensembl_gene_id: HI_0579
symbol: fusA
gene_biotype: protein_coding
description:
  Elongation factor G (fusA); Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity); Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family.  [...]


ensembl_gene_id: HI_0580
symbol: rpsG
gene_biotype: protein_coding
description:
  Ribosomal protein S7 (rpS7); One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family.


ensembl_gene_id: HI_0582
symbol: mnmG
gene_biotype: protein_coding
description:
  Glucose inhibited division protein (gidA); NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34; Belongs to the MnmG family.


ensembl_gene_id: HI_0583
symbol: cpdB
gene_biotype: protein_coding
description:
  2',3'-cyclic-nucleotide 2'-phosphodiesterase (cpdB); This bifunctional enzyme catalyzes two consecutive reactions during ribonucleic acid degradation. Converts a 2',3'-cyclic nucleotide to a 3'-nucleotide and then the 3'-nucleotide to the corresponding nucleoside and phosphate (By similarity).


ensembl_gene_id: HI_0584
symbol: abgA
gene_biotype: protein_coding
description:
  Hydrolase; Catalyzes the cleavage of p-aminobenzoyl-glutamate (PABA-GLU) to form p-aminobenzoate (PABA) and glutamate.


ensembl_gene_id: HI_0587
symbol: pepE
gene_biotype: protein_coding
description:
  Peptidase E (pepE); Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids.


ensembl_gene_id: HI_0588
symbol: HI_0588
gene_biotype: protein_coding
description:
  N-carbamyl-L-amino acid amidohydrolase; Similar to SP:P37113 GB:S67784 GB:X74289 PID:460895 SP:Q53389 percent identity: 35.94; identified by sequence similarity; putative; Belongs to the peptidase M20 family.


ensembl_gene_id: HI_0589
symbol: HI_0589
gene_biotype: protein_coding
description:
  Sigma factor regulatory protein, putative; Similar to SP:P46187 PID:987645 PID:1045631 PID:1050877 GB:U00096 percent identity: 29.01; identified by sequence similarity; putative.


ensembl_gene_id: HI_0590
symbol: potE
gene_biotype: protein_coding
description:
  Putrescine-ornithine antiporter (potE); Catalyzes both the uptake and excretion of putrescine. The uptake of putrescine is dependent on the membrane potential and the excretion involves putrescine-ornithine antiporter activity. Belongs to the amino acid-polyamine-organocation (APC) superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2) family.


ensembl_gene_id: HI_0591
symbol: speF
gene_biotype: protein_coding
description:
  Ornithine decarboxylase (speF); Similar to GB:M64495 SP:P24169 PID:147331 GB:U00096 PID:1651300 percent identity: 66.43; identified by sequence similarity; putative; Belongs to the Orn/Lys/Arg decarboxylase class-I family.


ensembl_gene_id: HI_0594
symbol: HI_0594
gene_biotype: protein_coding
description:
  Conserved hypothetical transmembrane protein; Similar to GB:AE000783 percent identity: 35.02; identified by sequence similarity; putative; To B.subtilis YcgA.


ensembl_gene_id: HI_0595
symbol: arcC
gene_biotype: protein_coding
description:
  Carbamate kinase (arcC); Similar to SP:P13982 GB:X14693 PID:45290 percent identity: 78.32; identified by sequence similarity; putative; Belongs to the carbamate kinase family.


ensembl_gene_id: HI_0596
symbol: arcB
gene_biotype: protein_coding
description:
  Ornithine carbamoyltransferase (arcB); Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.


ensembl_gene_id: HI_0597
symbol: HI_0597
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to SP:P27848 percent identity: 41.29; identified by sequence similarity; putative.


ensembl_gene_id: HI_0597.1
symbol: crcB
gene_biotype: protein_coding
description:
  crcB protein; Important for reducing fluoride concentration in the cell, thus reducing its toxicity; Belongs to the CrcB (TC 9.B.71) family.


ensembl_gene_id: HI_0600
symbol: recA
gene_biotype: protein_coding
description:
  recA protein (recA); Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage. Plays a central role in DNA metabolism, participating in general homologous recombination, recombinational (postreplication) DNA repair, and prophage induction; Belongs to the RecA family.


ensembl_gene_id: HI_0601
symbol: tfoX
gene_biotype: protein_coding
description:
  DNA transformation protein (tfoX); Required for DNA transformation. Positively regulates genes required for DNA transformation (late competence-specific genes) in association with CRP. Required for expression of the dprABC operon ; Belongs to the TfoX family.


ensembl_gene_id: HI_0602.1
symbol: HI_0602.1
gene_biotype: protein_coding
description:
  Predicted coding region HI0602.1; Brute Force ORF; identified by GeneMark; putative; To E.coli HemX C-terminal region.


ensembl_gene_id: HI_0603
symbol: HI_0603
gene_biotype: protein_coding
description:
  uroporphyrin-III C-methyltransferase (hemX); Similar to GB:M87049 SP:P09127 GB:X12614 GB:X13406 PID:148202 percent identity: 40.45; identified by sequence similarity; putative; To E.coli HemX N-terminal region.


ensembl_gene_id: HI_0605
symbol: gpsA
gene_biotype: protein_coding
description:
  Glycerol-3-phosphate dehydrogenase (NAD+) (gpsA); Similar to SP:P37606 PID:466746 GB:U00096 PID:1657692 PID:1790037 percent identity: 66.57; identified by sequence similarity; putative; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.


ensembl_gene_id: HI_0606
symbol: cysE
gene_biotype: protein_coding
description:
  Serine acetyltransferase (cysE); Similar to SP:P05796 GB:M15745 GB:M34333 PID:145676 PID:145694 percent identity: 73.05; identified by sequence similarity; putative.


ensembl_gene_id: HI_0607
symbol: sdhL
gene_biotype: protein_coding
description:
  Shikimate 5-dehydrogenase-related protein; In vitro, is able to catalyze the NADP(+)-dependent oxidation of shikimate to 3-dehydroshikimate. However, has much lower activity than classical shikimate dehydrogenases AroE, indicating that shikimate may not be the biological substrate. Cannot utilize NAD(+) instead of NADP(+). Is not able to catalyze the oxidation of quinate.


ensembl_gene_id: HI_0608
symbol: HI_0608
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:L77117 SP:Q58086 PID:1591386 percent identity: 40.10; identified by sequence similarity; putative.


ensembl_gene_id: HI_0609
symbol: folD
gene_biotype: protein_coding
description:
  Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase (folD); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.


ensembl_gene_id: HI_0610
symbol: fucP
gene_biotype: protein_coding
description:
  L-fucose permease (fucP); Transport of L-fucose into the cell; Belongs to the major facilitator superfamily. FHS transporter (TC 2.A.1.7) family.


ensembl_gene_id: HI_0611
symbol: fucA
gene_biotype: protein_coding
description:
  L-fuculose phosphate aldolase (fucA); Involved in the degradation of L-fucose and D-arabinose. Catalyzes the reversible cleavage of L-fuculose 1-phosphate (Fuc1P) to yield dihydroxyacetone phosphate (DHAP) and L-lactaldehyde.


ensembl_gene_id: HI_0613
symbol: fucK
gene_biotype: protein_coding
description:
  Fuculokinase (fucK); Catalyzes the phosphorylation of L-fuculose. Belongs to the FGGY kinase family.


ensembl_gene_id: HI_0616
symbol: rapA
gene_biotype: protein_coding
description:
  ATP-dependent helicase (hepA); Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair; Belongs to the SNF2/RAD54 helicase family. RapA subfamily.


ensembl_gene_id: HI_0617
symbol: rluA
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Dual specificity enzyme that catalyzes the synthesis of pseudouridine from uracil-746 in 23S ribosomal RNA and from uracil-32 in the anticodon stem and loop of transfer RNAs.


ensembl_gene_id: HI_0618
symbol: glpG
gene_biotype: protein_coding
description:
  Glp protein, putative; Rhomboid-type serine protease that catalyzes intramembrane proteolysis; Belongs to the peptidase S54 family.


ensembl_gene_id: HI_0620
symbol: metQ
gene_biotype: protein_coding
description:
  28 kDa outer membrane protein (hlpA); This protein is a component of a D-methionine permease, a binding protein-dependent, ATP-driven transport system; Belongs to the NlpA lipoprotein family.


ensembl_gene_id: HI_0621
symbol: metN
gene_biotype: protein_coding
description:
  ABC transporter, ATP-binding protein; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system.


ensembl_gene_id: HI_0621.1
symbol: gmhB
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate by removing the phosphate group at the C-7 position in vitro. Also catalyzes the dephosphorylation of D-glycero-alpha-D-manno-heptose 1,7- bisphosphate, phospho-serine and fructose-1,6-biphosphate in vitro. Belongs to the GmhB family.


ensembl_gene_id: HI_0622
symbol: def
gene_biotype: protein_coding
description:
  Polypeptide deformylase (def); Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity).


ensembl_gene_id: HI_0623
symbol: fmt
gene_biotype: protein_coding
description:
  methionyl-tRNA formyltransferase (fmt); Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family.


ensembl_gene_id: HI_0626
symbol: mscL
gene_biotype: protein_coding
description:
  Large conductance mechanosensitive channel (mscL); Channel that opens in response to stretch forces in the membrane lipid bilayer. Forms a nonselective ion channel with a conductance of about 4 nanosiemens. May participate in the regulation of osmotic pressure changes within the cell.


ensembl_gene_id: HI_0627
symbol: sdhE
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH and other flavinylated proteins as well.


ensembl_gene_id: HI_0628
symbol: rpoE
gene_biotype: protein_coding
description:
  RNA polymerase sigma-E factor (rpoE); Sigma factors are initiation factors that promote the attachment of RNA polymerase (RNAP) to specific initiation sites and are then released. Extracytoplasmic function (ECF) sigma-E controls the envelope stress response, responding to periplasmic protein stress, increased levels of periplasmic lipopolysaccharide (LPS) as well as heat shock and oxidative stress; it controls protein processing in the extracytoplasmic compartment (By similarity).


ensembl_gene_id: HI_0629
symbol: rseA
gene_biotype: protein_coding
description:
  sigma-E factor negative regulatory protein (mclA); An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytopl [...]


ensembl_gene_id: HI_0630
symbol: rseB
gene_biotype: protein_coding
description:
  sigma-E factor regulatory protein (rseB); Negatively modulates the activity of sigma-E (RpoE) by stabilizing RseA under non-stress conditions. Although not essential for association of sigma-E with Rsea it increases their affinity 2- to 3-fold. When bound to RseA it prevents proteolysis by DegS, which is probably relieved by lipopolysaccharide binding (LPS) (By similarity). Belongs to the RseB family.


ensembl_gene_id: HI_0631
symbol: coaA
gene_biotype: protein_coding
description:
  Pantothenate kinase (coaA); Similar to GB:M36321 SP:P15044 GB:M90071 PID:145560 PID:145561 percent identity: 64.10; identified by sequence similarity; putative.


ensembl_gene_id: HI_0632
symbol: HI_0632
gene_biotype: protein_coding
description:
  Elongation factor Tu (tufB); Similar to GB:U00006 SP:P02990 GB:J01717 GB:M10459 GB:X57091 percent identity: 92.64; identified by sequence similarity; putative.


ensembl_gene_id: HI_0634
symbol: dusA
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs; Belongs to the Dus family. DusA subfamily.


ensembl_gene_id: HI_0635
symbol: HI_0635
gene_biotype: protein_coding
description:
  Hemoglobin-binding protein; Acts as a receptor for hemoglobin or the hemoglobin/haptoglobin complex of the human host and is required for heme uptake.


ensembl_gene_id: HI_0636
symbol: HI_0636
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:U00096 PID:1788685 percent identity: 42.50; identified by sequence similarity; putative; Belongs to the UPF0381 family.


ensembl_gene_id: HI_0637
symbol: trpS
gene_biotype: protein_coding
description:
  tryptophanyl-tRNA synthetase (trpS); Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family.


ensembl_gene_id: HI_0638
symbol: hflD
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to SP:P25746 PID:581207 GB:U00096 PID:1787377 percent identity: 51.21; identified by sequence similarity; putative.


ensembl_gene_id: HI_0639
symbol: purB
gene_biotype: protein_coding
description:
  Adenylosuccinate lyase (purB); Similar to GB:M74924 SP:P25739 PID:145203 PID:42585 GB:U00096 percent identity: 76.97; identified by sequence similarity; putative.


ensembl_gene_id: HI_0640
symbol: rplJ
gene_biotype: protein_coding
description:
  Ribosomal protein L10 (rpL10); Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family.


ensembl_gene_id: HI_0641
symbol: rplL
gene_biotype: protein_coding
description:
  Ribosomal protein L7/L12 (rpL7/L12); Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family.


ensembl_gene_id: HI_0642
symbol: glmU
gene_biotype: protein_coding
description:
  UDP-N-acetylglucosamine pyrophosphorylase (glmU); Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family.


ensembl_gene_id: HI_0643
symbol: torZ
gene_biotype: protein_coding
description:
  Biotin sulfoxide reductase (bisC); Reduces trimethylamine-N-oxide (TMAO) into trimethylamine; an anaerobic reaction coupled to energy-yielding reactions.


ensembl_gene_id: HI_0644
symbol: torY
gene_biotype: protein_coding
description:
  Cytochrome C-type protein (yecK); Part of the anaerobic respiratory chain of trimethylamine-N- oxide reductase TorZ. Required for electron transfer to the TorZ terminal enzyme (By similarity).


ensembl_gene_id: HI_0645
symbol: pldB
gene_biotype: protein_coding
description:
  Lysophospholipase L2 (pldB); Similar to PID:1449198 percent identity: 37.83; identified by sequence similarity; putative.


ensembl_gene_id: HI_0646
symbol: asd
gene_biotype: protein_coding
description:
  Aspartate-semialdehyde dehydrogenase (asd); Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family.


ensembl_gene_id: HI_0647
symbol: HI_0647
gene_biotype: protein_coding
description:
  Transport protein, putative; Similar to GB:M57715 SP:P22037 PID:154179 percent identity: 42.40; identified by sequence similarity; putative.


ensembl_gene_id: HI_0649
symbol: rep
gene_biotype: protein_coding
description:
  ATP-dependent DNA helicase (rep); Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replication; it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction.


ensembl_gene_id: HI_0651
symbol: coaD
gene_biotype: protein_coding
description:
  Lipopolysaccharide core biosynthesis protein (kdtB); Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family.


ensembl_gene_id: HI_0652
symbol: waaA
gene_biotype: protein_coding
description:
  3-deoxy-d-manno-octulosonic-acid transferase (kdtA); Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of a single 3-deoxy-D-manno-octulosonate (Kdo) residue from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'- bisphosphate precursor of lipid A. Is strictly monofunctional, i.e. is capable of adding only a single Kdo residue to the acceptor lipid. Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 30 subfamily.


ensembl_gene_id: HI_0653
symbol: HI_0653
gene_biotype: protein_coding
description:
  Lipopolysaccharide biosynthesis protein; Similar to PID:1389735 percent identity: 51.43; identified by sequence similarity; putative; Belongs to the glycosyltransferase 2 family. WaaE/KdtX subfamily.


ensembl_gene_id: HI_0654
symbol: tag
gene_biotype: protein_coding
description:
  DNA-3-methyladenine glycosidase I (tagI); Hydrolysis of the deoxyribose N-glycosidic bond to excise 3- methyladenine from the damaged DNA polymer formed by alkylation lesions.


ensembl_gene_id: HI_0655
symbol: aroE
gene_biotype: protein_coding
description:
  Shikimate 5-dehydrogenase (aroE); Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).


ensembl_gene_id: HI_0656
symbol: tsaC
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate.


ensembl_gene_id: HI_0656.1
symbol: HI_0656.1
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to SP:P45771 PID:606217 GB:U00096 PID:1789677 percent identity: 48.32; identified by sequence similarity; putative; To E.coli YrdD.


ensembl_gene_id: HI_0658
symbol: yheS
gene_biotype: protein_coding
description:
  ABC transporter, ATP-binding protein; Genetic data indicate it may be involved in ribosome assembly or function.


ensembl_gene_id: HI_0663
symbol: HI_0663
gene_biotype: protein_coding
description:
  ATP-binding transport protein (cydD); Similar to SP:P27299 GB:Z11796 PID:42023 GB:U00096 PID:1651441 percent identity: 27.76; identified by sequence similarity; putative.


ensembl_gene_id: HI_0664
symbol: HI_0664
gene_biotype: protein_coding
description:
  ABC transporter, ATP-binding protein; Similar to GB:AL009126 percent identity: 29.51; identified by sequence similarity; putative.


ensembl_gene_id: HI_0665
symbol: HI_0665
gene_biotype: protein_coding
description:
  Predicted coding region HI0665; Hypothetical protein; identified by GeneMark; putative; Belongs to the HipA Ser/Thr kinase family.


ensembl_gene_id: HI_0668
symbol: zapB
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA.


ensembl_gene_id: HI_0669
symbol: mioC
gene_biotype: protein_coding
description:
  mioC protein (mioC); Probable electron transporter required for biotin synthase activity; Belongs to the flavodoxin family. MioC subfamily.


ensembl_gene_id: HI_0670
symbol: dtd
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family.


ensembl_gene_id: HI_0671
symbol: ispF
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity).


ensembl_gene_id: HI_0672
symbol: ispD
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).


ensembl_gene_id: HI_0673
symbol: ftsB
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.


ensembl_gene_id: HI_0674
symbol: gpt1
gene_biotype: protein_coding
description:
  Xanthine-guanine phosphoribosyltransferase (gptA); Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily.


ensembl_gene_id: HI_0676
symbol: xerC
gene_biotype: protein_coding
description:
  Integrase/recombinase (xerC); Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.


ensembl_gene_id: HI_0678
symbol: tpiA
gene_biotype: protein_coding
description:
  Triosephosphate isomerase (tpiA); Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family.


ensembl_gene_id: HI_0679
symbol: glpE
gene_biotype: protein_coding
description:
  glpE protein (glpE); Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide.


ensembl_gene_id: HI_0680
symbol: HI_0680
gene_biotype: protein_coding
description:
  rarD protein, putative; Similar to SP:P27844 percent identity: 27.15; identified by sequence similarity; putative.


ensembl_gene_id: HI_0681
symbol: ilvY
gene_biotype: protein_coding
description:
  Transcriptional activator (ilvY); This protein activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate. IlvY is also a negative regulator of its own expression (By similarity). Belongs to the LysR transcriptional regulatory family.


ensembl_gene_id: HI_0682
symbol: ilvC
gene_biotype: protein_coding
description:
  Ketol-acid reductoisomerase (ilvC); Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.


ensembl_gene_id: HI_0683
symbol: glpC
gene_biotype: protein_coding
description:
  Anaerobic glycerol-3-phosphate dehydrogenase, subunit C (glpC); Electron transfer protein; may also function as the membrane anchor for the GlpAB dimer.


ensembl_gene_id: HI_0684
symbol: glpB
gene_biotype: protein_coding
description:
  Anaerobic glycerol-3-phosphate dehydrogenase, subunit B (glpB); Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor (By similarity).


ensembl_gene_id: HI_0685
symbol: glpA
gene_biotype: protein_coding
description:
  Anaerobic glycerol-3-phosphate dehydrogenase, subunit A (glpA); Similar to GB:M20938 SP:P13032 PID:146177 GB:U00096 PID:1788574 percent identity: 70.24; identified by sequence similarity; putative; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.


ensembl_gene_id: HI_0686
symbol: glpT
gene_biotype: protein_coding
description:
  Glycerol-3-phosphatase transporter (glpT); Responsible for glycerol-3-phosphate uptake; Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.


ensembl_gene_id: HI_0687
symbol: HI_0687
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:D26185 SP:P37511 PID:467365 GB:AL009126 percent identity: 24.11; identified by sequence similarity; putative.


ensembl_gene_id: HI_0689
symbol: glpQ
gene_biotype: protein_coding
description:
  Glycerophosphoryl diester phosphodiesterase (glpQ); Glycerophosphoryl diester phosphodiesterase hydrolyzes deacylated phospholipids to G3P and the corresponding alcohols. Has a specific affinity for human immunoglobulin D myeloma protein.


ensembl_gene_id: HI_0690
symbol: glpF
gene_biotype: protein_coding
description:
  Glycerol uptake facilitator protein (glpF); Glycerol enters the cell via the glycerol diffusion facilitator protein. This membrane protein facilitates the movement of glycerol across the cytoplasmic membrane (By similarity).


ensembl_gene_id: HI_0691
symbol: glpK
gene_biotype: protein_coding
description:
  Glycerol kinase (glpK); Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family.


ensembl_gene_id: HI_0692
symbol: HI_0692
gene_biotype: protein_coding
description:
  Xanthine-guanine phosphoribosyltransferase (gptB); Similar to SP:P26972 GB:X52093 GB:X63336 PID:47695 percent identity: 74.03; identified by sequence similarity; putative.


ensembl_gene_id: HI_0693
symbol: hel
gene_biotype: protein_coding
description:
  Lipoprotein E (hel); Similar to GB:M68502 SP:P26093 PID:1573696 percent identity: 99.64; identified by sequence similarity; putative.


ensembl_gene_id: HI_0694
symbol: rluE
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Responsible for synthesis of pseudouridine from uracil-2457 in 23S ribosomal RNA; Belongs to the pseudouridine synthase RsuA family.


ensembl_gene_id: HI_0695
symbol: ppx
gene_biotype: protein_coding
description:
  Exopolyphosphatase, putative; Degradation of inorganic polyphosphates (polyP). Releases orthophosphate processively from the ends of the polyP chain.


ensembl_gene_id: HI_0696
symbol: tamB
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Part of the translocation and assembly module (TAM) autotransporter assembly complex, which functions in translocation of autotransporters across the outer membrane. Substrate binding to TamA moves its POTRA domains about 30 Angstroms into the periplasm, which would deform either the outer membrane or TamB and may provide force to reset TAM (By similarity).


ensembl_gene_id: HI_0698
symbol: tama
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Part of the translocation and assembly module (TAM) autotransporter assembly complex, which functions in translocation of autotransporters across the outer membrane. Has anion selective channel-forming ability, but the physiological relevance of this activity is unclear; Belongs to the TamA family.


ensembl_gene_id: HI_0699
symbol: slyD
gene_biotype: protein_coding
description:
  Peptidyl-prolyl cis-trans isomerase, FkbP-type (slyD); Folding helper with both chaperone and peptidyl-prolyl cis- trans isomerase (PPIase) activities. Chaperone activity prevents aggregation of unfolded or partially folded proteins and promotes their correct folding. PPIases catalyze the cis-trans isomerization of Xaa- Pro bonds of peptides, which accelerates slow steps of protein folding and thus shortens the lifetime of intermediates. Both strategies lower the concentration of intermediates and increase the productivity and yield of the folding reaction (By similarity); Belongs to t [...]


ensembl_gene_id: HI_0700
symbol: rraB
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome.


ensembl_gene_id: HI_0701
symbol: truD
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs; Belongs to the pseudouridine synthase TruD family.


ensembl_gene_id: HI_0702
symbol: surE
gene_biotype: protein_coding
description:
  Stationary-phase survival protein (surE); Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.


ensembl_gene_id: HI_0703
symbol: HI_0703
gene_biotype: protein_coding
description:
  Lipoprotein B (lppB); Similar to GB:L10653 SP:P36684 PID:148929 percent identity: 72.25; identified by sequence similarity; putative.


ensembl_gene_id: HI_0707
symbol: mutS
gene_biotype: protein_coding
description:
  DNA mismatch repair protein (mutS); This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity).


ensembl_gene_id: HI_0708
symbol: selA
gene_biotype: protein_coding
description:
  L-seryl-tRNA selenium transferase (selA); Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.


ensembl_gene_id: HI_0709
symbol: selB
gene_biotype: protein_coding
description:
  Selenocysteine-specific elongation factor (selB); Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP (By similarity); Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. SelB subfamily.


ensembl_gene_id: HI_0710
symbol: relB
gene_biotype: protein_coding
description:
  Predicted coding region HI0710; Antitoxin component of a type II toxin-antitoxin (TA) system. Its cognate toxin is YafQ (By similarity).


ensembl_gene_id: HI_0711
symbol: yafQ
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Toxic component of a type II toxin-antitoxin (TA) system. Its cognate antitoxin is RelB (By similarity).


ensembl_gene_id: HI_0713
symbol: tig
gene_biotype: protein_coding
description:
  Trigger factor (tig); Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase (By similarity). Belongs to the FKBP-type PPIase family. Tig subfamily.


ensembl_gene_id: HI_0714
symbol: clpP
gene_biotype: protein_coding
description:
  ATP-dependent Clp protease, proteolytic subunit (clpP); Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.


ensembl_gene_id: HI_0715
symbol: clpX
gene_biotype: protein_coding
description:
  ATP-dependent Clp protease, ATP-binding subunit (clpX); ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.


ensembl_gene_id: HI_0716
symbol: secE
gene_biotype: protein_coding
description:
  Preprotein translocase SecE subunit (secE); Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.


ensembl_gene_id: HI_0717
symbol: nusG
gene_biotype: protein_coding
description:
  Transcription antitermination protein (nusG); Participates in transcription elongation, termination and antitermination.


ensembl_gene_id: HI_0718
symbol: mlaA
gene_biotype: protein_coding
description:
  Lipoprotein (vacJ); Involved in a phospholipid transport pathway that maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. Belongs to the MlaA family.


ensembl_gene_id: HI_0719
symbol: HI_0719
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:U14003 SP:P39330 PID:537085 GB:U00096 PID:1790691 percent identity: 73.72; identified by sequence similarity; putative.


ensembl_gene_id: HI_0720
symbol: htpX
gene_biotype: protein_coding
description:
  Heat shock protein (htpX); Similar to GB:M58470 SP:P23894 PID:146412 GB:U00096 PID:1736470 percent identity: 66.32; identified by sequence similarity; putative; Belongs to the peptidase M48B family.


ensembl_gene_id: HI_0721
symbol: tusA
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Sulfur carrier protein which probably makes part of a sulfur- relay system; Belongs to the sulfur carrier protein TusA family.


ensembl_gene_id: HI_0722
symbol: HI_0722
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:U00096 PID:1790283 percent identity: 54.15; identified by sequence similarity; putative; Belongs to the IMPACT family.


ensembl_gene_id: HI_0723
symbol: trkH
gene_biotype: protein_coding
description:
  TRK system potassium uptake protein (trkH); Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA and requires TrkE for transport activity (By similarity); Belongs to the TrkH potassium transport family.


ensembl_gene_id: HI_0724
symbol: yihI
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function. May play a role in ribosome biogenesis. Belongs to the YihI family.


ensembl_gene_id: HI_0725
symbol: HI_0725
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to PID:1685094 percent identity: 47.62; identified by sequence similarity; putative.


ensembl_gene_id: HI_0726
symbol: narP
gene_biotype: protein_coding
description:
  Nitrate/nitrite response regulator protein (narP); Could activate the expression of a formate dehydrogenase operon and could repress the transcription of the fumarate reductase (frdABCD) operon.


ensembl_gene_id: HI_0727
symbol: lysA
gene_biotype: protein_coding
description:
  Diaminopimelate decarboxylase (lysA); Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine.


ensembl_gene_id: HI_0727.1
symbol: cyaY
gene_biotype: protein_coding
description:
  cyaY protein (cyaY); Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis.


ensembl_gene_id: HI_0729
symbol: proS
gene_biotype: protein_coding
description:
  prolyl-tRNA synthetase (proS); Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and invol [...]


ensembl_gene_id: HI_0730
symbol: lptD
gene_biotype: protein_coding
description:
  Organic solvent tolerance protein; Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.


ensembl_gene_id: HI_0733
symbol: ftsP
gene_biotype: protein_coding
description:
  sufI protein (sufI); Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity).


ensembl_gene_id: HI_0734
symbol: plsC
gene_biotype: protein_coding
description:
  1-acyl-glycerol-3-phosphate acyltransferase (plsC); Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating acyl moiety at the 2 position.


ensembl_gene_id: HI_0735
symbol: lpxH
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the LpxH family.


ensembl_gene_id: HI_0736
symbol: HI_0736
gene_biotype: protein_coding
description:
  Sodium-dependent transporter, putative; Putative sodium-dependent transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.


ensembl_gene_id: HI_0737
symbol: HI_0737
gene_biotype: protein_coding
description:
  Acetohydroxy acid synthase II, putative; Truncated acetolactase synthase; no longer catalytically active.


ensembl_gene_id: HI_0738
symbol: ilvD
gene_biotype: protein_coding
description:
  Dihydroxyacid dehydratase (ilvD); Similar to SP:P05791 GB:M10313 GB:K03503 GB:M32253 GB:X02413 percent identity: 76.87; identified by sequence similarity; putative; Belongs to the IlvD/Edd family.


ensembl_gene_id: HI_0738.1
symbol: ilvA
gene_biotype: protein_coding
description:
  Threonine deaminase (ilvA); Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA (By similarity).


ensembl_gene_id: HI_0739
symbol: dnaE
gene_biotype: protein_coding
description:
  DNA polymerase III, alpha subunit (dnaE); DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase (By similarity); Belongs to the DNA polymerase type-C family. DnaE subfamily.


ensembl_gene_id: HI_0740
symbol: HI_0740
gene_biotype: protein_coding
description:
  Phosphomannomutase (yhxB); Similar to GB:M34393 SP:P18159 PID:142994 PID:2226139 GB:AL009126 percent identity: 38.72; identified by sequence similarity; putative; Belongs to the phosphohexose mutase family.


ensembl_gene_id: HI_0742
symbol: HI_0742
gene_biotype: protein_coding
description:
  Predicted coding region HI0742; Hypothetical protein; identified by GeneMark; putative; To E.coli YtfG C-terminal region.


ensembl_gene_id: HI_0743
symbol: secB
gene_biotype: protein_coding
description:
  Protein-export protein (secB); One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA.


ensembl_gene_id: HI_0744
symbol: HI_0744
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to SP:P37688 PID:466749 GB:U00096 PID:1790040 percent identity: 50.74; identified by sequence similarity; putative.


ensembl_gene_id: HI_0745
symbol: ansB
gene_biotype: protein_coding
description:
  L-asparaginase II (ansB); Similar to GB:M34234 SP:P00805 GB:M34277 PID:145277 PID:146597 percent identity: 70.52; identified by sequence similarity; putative; Belongs to the asparaginase 1 family.


ensembl_gene_id: HI_0746
symbol: dcuB
gene_biotype: protein_coding
description:
  Anaerobic C4-dicarboxylate membrane transporter protein (dcuB); Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane; Belongs to the DcuA/DcuB transporter (TC 2.A.13.1) family.


ensembl_gene_id: HI_0747
symbol: ndh
gene_biotype: protein_coding
description:
  NADH dehydrogenase (ndh); Transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Does not couple the redox reaction to proton translocation (By similarity).


ensembl_gene_id: HI_0748
symbol: plsB
gene_biotype: protein_coding
description:
  Glycerol-3-phosphate acyltransferase (plsB); Similar to SP:P00482 GB:K00127 PID:147295 PID:148102 PID:148109 percent identity: 57.21; identified by sequence similarity; putative; Belongs to the GPAT/DAPAT family.


ensembl_gene_id: HI_0749
symbol: lexA
gene_biotype: protein_coding
description:
  lexA repressor (lexA); Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.


ensembl_gene_id: HI_0750
symbol: dapF
gene_biotype: protein_coding
description:
  Diaminopimelate epimerase (dapF); Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. Only accepts DAP isomers with the L configuration ; Belongs to the diaminopimelate epimerase family.


ensembl_gene_id: HI_0751
symbol: tpx
gene_biotype: protein_coding
description:
  Thiol peroxidase (tpx); Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Tpx subfamily.


ensembl_gene_id: HI_0752
symbol: purL
gene_biotype: protein_coding
description:
  Phosphoribosylformylglycinamidine synthase (purL); Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.


ensembl_gene_id: HI_0753
symbol: anmK
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family.


ensembl_gene_id: HI_0754
symbol: murQ
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity).


ensembl_gene_id: HI_0755
symbol: HI_0755
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to SP:P37691 PID:912478 GB:U00096 PID:1790043 percent identity: 41.83; identified by sequence similarity; putative; To E.coli YibQ.


ensembl_gene_id: HI_0756
symbol: HI_0756
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to SP:P37690 PID:466751 GB:U00096 PID:1790042 percent identity: 40.55; identified by sequence similarity; putative.


ensembl_gene_id: HI_0757
symbol: gpmA
gene_biotype: protein_coding
description:
  Phosphoglycerate mutase (gpmA); Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily.


ensembl_gene_id: HI_0759
symbol: mutY
gene_biotype: protein_coding
description:
  A/G-specific adenine glycosylase (mutY); Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine: 7,8-dihydro-8-oxoguanine (8-oxo- dGTP); Belongs to the Nth/MutY family.


ensembl_gene_id: HI_0760
symbol: HI_0760
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes.


ensembl_gene_id: HI_0761
symbol: mltC
gene_biotype: protein_coding
description:
  Membrane-bound lytic murein transglycosylase C (mltC); Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division.


ensembl_gene_id: HI_0763
symbol: nadR
gene_biotype: protein_coding
description:
  Transcriptional regulator (nadR); This enzyme has two activities: nicotinamide mononucleotide (NMN) adenylyltransferase and ribosylnicotinamide (RN) kinase. The RN kinase activity catalyzes the phosphorylation of RN to form nicotinamide ribonucleotide. The NMN adenylyltransferase activity catalyzes the transfer of the AMP moiety of ATP to nicotinamide ribonucleotide to form NAD(+); In the C-terminal section; belongs to the bacterial RNK family.


ensembl_gene_id: HI_0764
symbol: ribB
gene_biotype: protein_coding
description:
  3,4-dihydroxy-2-butanone 4-phosphate synthase (ribB); Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.


ensembl_gene_id: HI_0765
symbol: HI_0765
gene_biotype: protein_coding
description:
  Lipooligosaccharide biosynthesis protein; Similar to GB:M37913 GB:L19441 PID:1573535 percent identity: 26.32; identified by sequence similarity; putative; Belongs to the glycosyltransferase 25 family.


ensembl_gene_id: HI_0766
symbol: trmL
gene_biotype: protein_coding
description:
  rRNA methylase, putative; Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.


ensembl_gene_id: HI_0767
symbol: rsmD
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle; Belongs to the methyltransferase superfamily. RsmD family.


ensembl_gene_id: HI_0768
symbol: ftsY
gene_biotype: protein_coding
description:
  Cell division protein (ftsY); Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.


ensembl_gene_id: HI_0769
symbol: ftsE
gene_biotype: protein_coding
description:
  Cell division ATP-binding protein (ftsE); Part of the ABC transporter FtsEX involved in cellular division. Important for assembly or stability of the septal ring.


ensembl_gene_id: HI_0771
symbol: atoB
gene_biotype: protein_coding
description:
  acetyl-CoA acetyltransferase (atoB); Similar to GB:U00096 SP:P76461 PID:1736879 PID:1788554 PID:1799573 percent identity: 66.92; identified by sequence similarity; putative.


ensembl_gene_id: HI_0772
symbol: atoE
gene_biotype: protein_coding
description:
  Short-chain fatty acids transporter (atoE); May be responsible for the uptake of short-chain fatty acids.


ensembl_gene_id: HI_0773
symbol: atoA
gene_biotype: protein_coding
description:
  Acetate CoA-transferase, beta subunit (atoA); Similar to GB:U00096 SP:P76459 PID:1736877 PID:1788552 percent identity: 70.14; identified by sequence similarity; putative.


ensembl_gene_id: HI_0774
symbol: atoD
gene_biotype: protein_coding
description:
  Acetate CoA-transferase, alpha subunit; Similar to GB:U00096 SP:P76458 PID:1736876 PID:1788551 percent identity: 63.13; identified by sequence similarity; putative.


ensembl_gene_id: HI_0775
symbol: HI_0775
gene_biotype: protein_coding
description:
  Transcriptional regulator; Similar to GB:X73124 SP:P39592 PID:413948 GB:AL009126 percent identity: 30.80; identified by sequence similarity; putative; Belongs to the LysR transcriptional regulatory family.


ensembl_gene_id: HI_0776
symbol: rpsJ
gene_biotype: protein_coding
description:
  Ribosomal protein S10 (rpS10); Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family.


ensembl_gene_id: HI_0777
symbol: rplC
gene_biotype: protein_coding
description:
  Ribosomal protein L3 (rpL3); One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.


ensembl_gene_id: HI_0778
symbol: rplD
gene_biotype: protein_coding
description:
  Ribosomal protein L4 (rpL4); One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity). This protein when expressed in E.coli represses both transcription and translation of the endogenous S10 operon. As the H.influenzae S10 leader can be regulated in vitro by the E.coli L4 protein this strongly suggests the endogenous protein controls its own S10 operon in a sim [...]


ensembl_gene_id: HI_0779
symbol: rplW
gene_biotype: protein_coding
description:
  Ribosomal protein L23 (rpL23); One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family.


ensembl_gene_id: HI_0780
symbol: rplB
gene_biotype: protein_coding
description:
  Ribosomal protein L2 (rpL2); One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family.


ensembl_gene_id: HI_0781
symbol: rpsS
gene_biotype: protein_coding
description:
  Ribosomal protein S19 (rpS19); Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.


ensembl_gene_id: HI_0782
symbol: rplV
gene_biotype: protein_coding
description:
  Ribosomal protein L22 (rpL22); This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity).


ensembl_gene_id: HI_0783
symbol: rpsC
gene_biotype: protein_coding
description:
  Ribosomal protein S3 (rpS3); Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family.


ensembl_gene_id: HI_0784
symbol: rplP
gene_biotype: protein_coding
description:
  Ribosomal protein L16 (rpL16); Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family.


ensembl_gene_id: HI_0785
symbol: rpmC
gene_biotype: protein_coding
description:
  Ribosomal protein L29 (rpL29); Similar to SP:P55840 PID:1841330 percent identity: 90.48; identified by sequence similarity; putative; Belongs to the universal ribosomal protein uL29 family.


ensembl_gene_id: HI_0786
symbol: rpsQ
gene_biotype: protein_coding
description:
  Ribosomal protein S17 (rpS17); One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.


ensembl_gene_id: HI_0788
symbol: rplN
gene_biotype: protein_coding
description:
  Ribosomal protein L14 (rpL14); Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family.


ensembl_gene_id: HI_0789
symbol: rplX
gene_biotype: protein_coding
description:
  Ribosomal protein L24 (rpL24); One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.


ensembl_gene_id: HI_0790
symbol: rplE
gene_biotype: protein_coding
description:
  Ribosomal protein L5 (rpL5); This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.


ensembl_gene_id: HI_0791
symbol: rpsN
gene_biotype: protein_coding
description:
  Ribosomal protein S14 (rpS14); Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site; Belongs to the universal ribosomal protein uS14 family.


ensembl_gene_id: HI_0792
symbol: rpsH
gene_biotype: protein_coding
description:
  Ribosomal protein S8 (rpS8); One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family.


ensembl_gene_id: HI_0793
symbol: rplF
gene_biotype: protein_coding
description:
  Ribosomal protein L6 (rpL6); This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family.


ensembl_gene_id: HI_0794
symbol: rplR
gene_biotype: protein_coding
description:
  Ribosomal protein L18 (rpL18); This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.


ensembl_gene_id: HI_0795
symbol: rpsE
gene_biotype: protein_coding
description:
  Ribosomal protein S5 (rpS5); With S4 and S12 plays an important role in translational accuracy; Belongs to the universal ribosomal protein uS5 family.


ensembl_gene_id: HI_0796
symbol: rpmD
gene_biotype: protein_coding
description:
  Ribosomal protein L30 (rpL30); Similar to GB:X01563 SP:P02430 GB:M24532 PID:42987 PID:606236 percent identity: 79.66; identified by sequence similarity; putative.


ensembl_gene_id: HI_0797
symbol: rplO
gene_biotype: protein_coding
description:
  Ribosomal protein L15 (rpL15); Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family.


ensembl_gene_id: HI_0798
symbol: secY
gene_biotype: protein_coding
description:
  Preprotein translocase SecY subunit (secY); The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.


ensembl_gene_id: HI_0798.1
symbol: rpmJ
gene_biotype: protein_coding
description:
  Ribosomal protein L36 (rpL36); Similar to SP:P21194 GB:M12432 PID:42990 PID:606233 PID:1128970 percent identity: 84.21; identified by sequence similarity; putative; Belongs to the bacterial ribosomal protein bL36 family.


ensembl_gene_id: HI_0799
symbol: rpsM
gene_biotype: protein_coding
description:
  Ribosomal protein S13 (rpS13); Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Belongs to the universal ribosomal protein uS13 family.


ensembl_gene_id: HI_0800
symbol: rpsK
gene_biotype: protein_coding
description:
  Ribosomal protein S11 (rpS11); Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family.


ensembl_gene_id: HI_0801
symbol: rpsD
gene_biotype: protein_coding
description:
  Ribosomal protein S4 (rpS4); One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.


ensembl_gene_id: HI_0802
symbol: rpoA
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerase, alpha chain (rpoA); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.


ensembl_gene_id: HI_0803
symbol: rplQ
gene_biotype: protein_coding
description:
  Ribosomal protein L17 (rplQ); Similar to GB:J01685 SP:P02416 GB:X00766 PID:147716 PID:42800 percent identity: 89.76; identified by sequence similarity; putative.


ensembl_gene_id: HI_0806
symbol: HI_0806
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:L77117 SP:Q57883 PID:1591145 percent identity: 26.80; identified by sequence similarity; putative.


ensembl_gene_id: HI_0807
symbol: dxr
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family.


ensembl_gene_id: HI_0808
symbol: frr
gene_biotype: protein_coding
description:
  Ribosome releasing factor (rrf); Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family.


ensembl_gene_id: HI_0809
symbol: pckA
gene_biotype: protein_coding
description:
  Phosphoenolpyruvate carboxykinase (pckA); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.


ensembl_gene_id: HI_0810
symbol: hslO
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.


ensembl_gene_id: HI_0811
symbol: argH
gene_biotype: protein_coding
description:
  Argininosuccinate lyase (argH); Similar to SP:P11447 GB:J01590 GB:M21446 PID:145335 PID:396307 percent identity: 73.52; identified by sequence similarity; putative.


ensembl_gene_id: HI_0812
symbol: galU
gene_biotype: protein_coding
description:
  Glucosephosphate uridylyltransferase (galU); May play a role in stationary phase survival; Belongs to the UDPGP type 2 family.


ensembl_gene_id: HI_0813
symbol: csrA
gene_biotype: protein_coding
description:
  Carbon storage regulator (csrA); A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s).


ensembl_gene_id: HI_0814
symbol: alaS
gene_biotype: protein_coding
description:
  alanyl-tRNA synthetase (alaS); Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.


ensembl_gene_id: HI_0815
symbol: uspA
gene_biotype: protein_coding
description:
  Universal stress protein A (uspA); Required for resistance to DNA-damaging agents. Belongs to the universal stress protein A family.


ensembl_gene_id: HI_0816
symbol: pepP
gene_biotype: protein_coding
description:
  Aminopeptidase P (pepP); Similar to GB:D00398 SP:P15034 PID:216529 PID:216627 PID:882438 percent identity: 54.59; identified by sequence similarity; putative.


ensembl_gene_id: HI_0817
symbol: HI_0817
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:D90281 SP:P25533 PID:216626 PID:882439 GB:U00096 percent identity: 46.41; identified by sequence similarity; putative; Belongs to the UPF0149 family.


ensembl_gene_id: HI_0818
symbol: galM
gene_biotype: protein_coding
description:
  Aldose 1-epimerase (galM); Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity).


ensembl_gene_id: HI_0819
symbol: galK
gene_biotype: protein_coding
description:
  Galactokinase (galK); Catalyzes the transfer of the gamma-phosphate of ATP to D- galactose to form alpha-D-galactose-1-phosphate (Gal-1-P). Belongs to the GHMP kinase family. GalK subfamily.


ensembl_gene_id: HI_0820
symbol: galT
gene_biotype: protein_coding
description:
  Galactose-1-phosphate uridylyltransferase (galT); Similar to SP:P31764 GB:X65934 PID:1573833 percent identity: 99.14; identified by sequence similarity; putative.


ensembl_gene_id: HI_0821
symbol: galR
gene_biotype: protein_coding
description:
  Galactose operon repressor (galR); Repressor of the galactose operon. Binds galactose as an inducer.


ensembl_gene_id: HI_0822
symbol: mglB
gene_biotype: protein_coding
description:
  Galactose ABC transporter, periplasmic-binding protein (mglB); This protein is involved in the active transport of galactose and glucose.


ensembl_gene_id: HI_0823
symbol: mglA
gene_biotype: protein_coding
description:
  Galactoside ABC transporter, ATP-binding protein (mglA); Part of the ABC transporter complex MglABC involved in galactose/methyl galactoside import. Responsible for energy coupling to the transport system.


ensembl_gene_id: HI_0824
symbol: mglC
gene_biotype: protein_coding
description:
  Galactoside ABC transporter, permease protein (mglC); Part of the binding-protein-dependent transport system for galactoside. Probably responsible for the translocation of the substrate across the membrane (By similarity).


ensembl_gene_id: HI_0826
symbol: HI_0826
gene_biotype: protein_coding
description:
  Conserved hypothetical transmembrane protein; Involved in cell division; probably involved in intracellular septation; Belongs to the YciB family.


ensembl_gene_id: HI_0827
symbol: HI_0827
gene_biotype: protein_coding
description:
  Conserved hypothetical; Similar to GB:K00431 SP:P04379 PID:455187 PID:902382 PID:902391 percent identity: 69.35; identified by sequence similarity; putative; Belongs to the acyl coenzyme A hydrolase family.


ensembl_gene_id: HI_0828
symbol: HI_0828
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to SP:P31070 percent identity: 67.35; identified by sequence similarity; putative.


ensembl_gene_id: HI_0829
symbol: slt
gene_biotype: protein_coding
description:
  Soluble lytic murein transglycosylase, putative; Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division (By similarity).


ensembl_gene_id: HI_0830
symbol: trpR
gene_biotype: protein_coding
description:
  Trp operon repressor (trpR); This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon and prevents the initiation of transcription (By similarity).


ensembl_gene_id: HI_0831
symbol: mtgA
gene_biotype: protein_coding
description:
  Monofunctional biosynthetic peptidoglycan transglycosylase; Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors; Belongs to the glycosyltransferase 51 family.


ensembl_gene_id: HI_0832
symbol: frdD
gene_biotype: protein_coding
description:
  Fumarate reductase, 13 kDa hydrophobic protein (frdD); Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane.


ensembl_gene_id: HI_0833
symbol: frdC
gene_biotype: protein_coding
description:
  Fumarate reductase, 15 kDa hydrophobic protein (frdC); Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane.


ensembl_gene_id: HI_0834
symbol: frdB
gene_biotype: protein_coding
description:
  Fumarate reductase, iron-sulfur protein (frdB); Similar to GB:U14003 SP:P00364 GB:J01611 PID:145264 PID:536997 percent identity: 75.51; identified by sequence similarity; putative.


ensembl_gene_id: HI_0835
symbol: frdA
gene_biotype: protein_coding
description:
  Fumarate reductase, flavoprotein subunit (frdA); Similar to GB:U14003 SP:P00363 GB:J01611 PID:145263 PID:536998 percent identity: 75.54; identified by sequence similarity; putative.


ensembl_gene_id: HI_0836
symbol: epmA
gene_biotype: protein_coding
description:
  lysyl-tRNA synthetase analog (genX); With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF- P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta-lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P; Belongs to the class-II aminoacyl-tRNA synthetase family. EpmA subfamily.


ensembl_gene_id: HI_0838
symbol: bamE
gene_biotype: protein_coding
description:
  Small protein A, putative; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.


ensembl_gene_id: HI_0839
symbol: HI_0839
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to SP:P33920 PID:405914 GB:U00096 PID:1788513 percent identity: 52.38; identified by sequence similarity; putative.


ensembl_gene_id: HI_0840
symbol: HI_0840
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to SP:P33921 PID:405915 GB:U00096 PID:1788514 percent identity: 45.71; identified by sequence similarity; putative; Belongs to the UPF0352 family.


ensembl_gene_id: HI_0841
symbol: HI_0841
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to SP:P33922 PID:453987 GB:U00096 PID:1788515 percent identity: 41.57; identified by sequence similarity; putative; To E.coli YejM.


ensembl_gene_id: HI_0842
symbol: HI_0842
gene_biotype: protein_coding
description:
  Predicted coding region HI0842; Hypothetical protein; identified by GeneMark; putative; Belongs to the metallo-dependent hydrolases superfamily.


ensembl_gene_id: HI_0844
symbol: mobA
gene_biotype: protein_coding
description:
  Molybdopterin-guanine dinucleotide biosynthesis protein (mob); Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor; Belongs to the MobA family.


ensembl_gene_id: HI_0845
symbol: HI_0845
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:L19201 SP:P32126 PID:304964 GB:U00096 PID:1790289 percent identity: 65.91; identified by sequence similarity; putative; To E.coli YihD.


ensembl_gene_id: HI_0846
symbol: dsbA
gene_biotype: protein_coding
description:
  Periplasmic oxidoreductase (por); Involved in disulfide-bond formation. Required for HI transformation. Acts by transferring its disulfide bond to other proteins; Belongs to the thioredoxin family. DsbA subfamily.


ensembl_gene_id: HI_0847
symbol: HI_0847
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Not known, a mutation in ORF3 causes a slight decrease in transformation efficiency.


ensembl_gene_id: HI_0848
symbol: trmA
gene_biotype: protein_coding
description:
  tRNA (uracil-5-)-methyltransferase (trmA); Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA).


ensembl_gene_id: HI_0850
symbol: HI_0850
gene_biotype: protein_coding
description:
  sigma-E factor regulatory protein, putative; Similar to SP:P46187 PID:987645 PID:1045631 PID:1050877 GB:U00096 percent identity: 35.66; identified by sequence similarity; putative.


ensembl_gene_id: HI_0851
symbol: mobB
gene_biotype: protein_coding
description:
  Molybdopterin-guanine dinucleotide biosynthesis protein B (mobB); GTP-binding protein that is not required for the biosynthesis of Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor, and not necessary for the formation of active molybdoenzymes using this form of molybdenum cofactor. May act as an adapter protein to achieve the efficient biosynthesis and utilization of MGD. Displays a weak intrinsic GTPase activity (By similarity); Belongs to the MobB family.


ensembl_gene_id: HI_0852
symbol: hsrA
gene_biotype: protein_coding
description:
  Conserved hypothetical transmembrane protein; Similar to GB:L10328 SP:P31474 PID:290604 GB:U00096 PID:1790195 percent identity: 44.91; identified by sequence similarity; putative.


ensembl_gene_id: HI_0853
symbol: hbpA
gene_biotype: protein_coding
description:
  Heme-binding lipoprotein (dppA); Important role in heme acquisition or metabolism; Belongs to the bacterial solute-binding protein 5 family.


ensembl_gene_id: HI_0854
symbol: HI_0854
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Involved in heme iron utilization. Catalyzes the degradation of heme to biliverdin, with the release of iron and carbon monoxide.


ensembl_gene_id: HI_0855
symbol: HI_0855
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to SP:P42627 PID:606050 GB:U00096 PID:1789496 percent identity: 65.43; identified by sequence similarity; putative; Belongs to the UPF0597 family.


ensembl_gene_id: HI_0856
symbol: polA
gene_biotype: protein_coding
description:
  DNA polymerase I (polA); In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity.


ensembl_gene_id: HI_0857
symbol: zapA
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity).


ensembl_gene_id: HI_0858
symbol: HI_0858
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Involved in the removal of 5-formyltetrahydrofolate. In vitro, it is a potent inhibitor of various folate-dependent enzymes in the C1 metabolism network and in vivo it might function as a folate storage. 5-formyltetrahydrofolate is also used as an antifolate rescue agent in cancer chemotherapy. Catalyzes the irreversible ATP-dependent transformation of 5-formyltetrahydrofolate (5-CHO-THF) to form 5,10- methenyltetrahydrofolate (5,10-CH=THF). The reverse reaction is catalyzed by the serine hydroxymethyltransferase GlyA (SHMT) (By similarity).


ensembl_gene_id: HI_0859
symbol: clpB
gene_biotype: protein_coding
description:
  ATP-dependent Clp protease, ATPase subunit (clpB); Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity). Belongs to th [...]


ensembl_gene_id: HI_0861
symbol: rnr
gene_biotype: protein_coding
description:
  Virulence-associated protein (vacB); 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.


ensembl_gene_id: HI_0862
symbol: HI_0862
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.


ensembl_gene_id: HI_0863
symbol: pdxH
gene_biotype: protein_coding
description:
  Pyridoxamine phosphate oxidase (pdxH); Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).


ensembl_gene_id: HI_0864
symbol: bipA
gene_biotype: protein_coding
description:
  GTP-binding protein; A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.


ensembl_gene_id: HI_0865
symbol: glnA
gene_biotype: protein_coding
description:
  Glutamine synthetase (glnA); Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia; Belongs to the glutamine synthetase family.


ensembl_gene_id: HI_0867
symbol: HI_0867
gene_biotype: protein_coding
description:
  Lipopolysaccharide biosynthesis protein, putative; Similar to SP:P37781 PID:454902 percent identity: 23.26; identified by sequence similarity; putative.


ensembl_gene_id: HI_0868
symbol: HI_0868
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:AL009126 percent identity: 35.37; identified by sequence similarity; putative; Belongs to the glycosyltransferase 2 family.


ensembl_gene_id: HI_0873
symbol: rffG
gene_biotype: protein_coding
description:
  DTDP-glucose 4,6-dehydratase (rffG); Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6- deoxy-D-xylo-4-hexulose via a three-step process involving oxidation, dehydration and reduction; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.


ensembl_gene_id: HI_0876
symbol: ndk
gene_biotype: protein_coding
description:
  Nucleoside diphosphate kinase (ndk); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.


ensembl_gene_id: HI_0877
symbol: obg
gene_biotype: protein_coding
description:
  GTP-binding protein (yhbZ); An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.


ensembl_gene_id: HI_0878
symbol: HI_0878
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to SP:P28636 PID:216638 PID:606122 GB:U00096 PID:1789575 percent identity: 49.34; identified by sequence similarity; putative.


ensembl_gene_id: HI_0879
symbol: rpmA
gene_biotype: protein_coding
description:
  Ribosomal protein L27 (rpL27); Similar to GB:D13267 SP:P02427 PID:216637 PID:606123 GB:U00096 percent identity: 87.06; identified by sequence similarity; putative; Belongs to the bacterial ribosomal protein bL27 family.


ensembl_gene_id: HI_0880
symbol: rplU
gene_biotype: protein_coding
description:
  Ribosomal protein L21 (rpL21); This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family.


ensembl_gene_id: HI_0881
symbol: ispB
gene_biotype: protein_coding
description:
  Octaprenyl-diphosphate synthase (ispB); Supplies octaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinones ubiquinone and menaquinone.


ensembl_gene_id: HI_0882
symbol: queH
gene_biotype: protein_coding
description:
  Predicted coding region HI0882; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).


ensembl_gene_id: HI_0883
symbol: HI_0883
gene_biotype: protein_coding
description:
  Amino acid carrier protein, putative; Similar to PID:757741 SP:Q45068 PID:1405464 GB:AL009126 percent identity: 39.09; identified by sequence similarity; putative.


ensembl_gene_id: HI_0884
symbol: arcA
gene_biotype: protein_coding
description:
  Aerobic respiration control protein ARCA (arcA); Member of the two-component regulatory system ArcB/ArcA. Represses a wide variety of aerobic enzymes under anaerobic conditions (By similarity).


ensembl_gene_id: HI_0885
symbol: dsbD
gene_biotype: protein_coding
description:
  Thiol:disulfide interchange protein (dsbD); Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity); Belongs to the thioredoxin family. DsbD subfamily.


ensembl_gene_id: HI_0887
symbol: purH
gene_biotype: protein_coding
description:
  Phosphoribosylaminoimidazolecarboxamide formyltransferase (purH); Similar to SP:P15639 GB:J05126 GB:X51950 PID:147420 PID:396345 percent identity: 77.19; identified by sequence similarity; putative.


ensembl_gene_id: HI_0888
symbol: purD
gene_biotype: protein_coding
description:
  Phosphoribosylamine--glycine ligase (purD); Similar to SP:P15640 GB:J05126 GB:X51950 PID:147421 PID:396344 percent identity: 75.18; identified by sequence similarity; putative.


ensembl_gene_id: HI_0889
symbol: glyA
gene_biotype: protein_coding
description:
  Serine hydroxymethyltransferase (serine methylase) (glyA); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.


ensembl_gene_id: HI_0890
symbol: coaE
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family.


ensembl_gene_id: HI_0891
symbol: yacG
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C- terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.


ensembl_gene_id: HI_0892
symbol: rhlB
gene_biotype: protein_coding
description:
  ATP-dependent RNA helicase (rhlB); DEAD-box RNA helicase involved in RNA degradation. Has RNA- dependent ATPase activity and unwinds double-stranded RNA. Belongs to the DEAD box helicase family. RhlB subfamily.


ensembl_gene_id: HI_0893
symbol: HI_0893
gene_biotype: protein_coding
description:
  Transcriptional repressor (Bm3R1); Similar to GB:S87512 SP:P43506 PID:623036 PID:247052 percent identity: 23.89; identified by sequence similarity; putative.


ensembl_gene_id: HI_0894
symbol: HI_0894
gene_biotype: protein_coding
description:
  Lipoprotein, putative; Similar to GB:U14993 SP:P43505 PID:438192 PID:550460 percent identity: 30.92; identified by sequence similarity; putative.


ensembl_gene_id: HI_0895
symbol: HI_0895
gene_biotype: protein_coding
description:
  Acriflavine resistance protein (acrB); Could be a drug efflux pump; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.


ensembl_gene_id: HI_0896
symbol: HI_0896
gene_biotype: protein_coding
description:
  Cell division protein (ftsN); Similar to GB:L19201 SP:P29131 GB:L14281 PID:290448 PID:305036 percent identity: 29.08; identified by sequence similarity; putative; To E.coli FtsN repeat regions.


ensembl_gene_id: HI_0897
symbol: emrB
gene_biotype: protein_coding
description:
  Multidrug resistance protein B (emrB); Confers resistance to antibiotics; Belongs to the major facilitator superfamily. EmrB family.


ensembl_gene_id: HI_0898
symbol: emrA
gene_biotype: protein_coding
description:
  Multidrug resistance protein A (emrA); Confers resistance to antibiotics; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.


ensembl_gene_id: HI_0899
symbol: folA
gene_biotype: protein_coding
description:
  Dihydrofolate reductase (folA); Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity); Belongs to the dihydrofolate reductase family.


ensembl_gene_id: HI_0900
symbol: proB
gene_biotype: protein_coding
description:
  Glutamate 5-kinase (gamma-glutamyl kinase) (proB); Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.


ensembl_gene_id: HI_0901
symbol: rppH
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily.


ensembl_gene_id: HI_0902
symbol: HI_0902
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:L77117 SP:Q57883 PID:1591145 percent identity: 28.84; identified by sequence similarity; putative.


ensembl_gene_id: HI_0904
symbol: lgt
gene_biotype: protein_coding
description:
  Prolipoprotein diacylglyceryl transferase (lgt); Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family.


ensembl_gene_id: HI_0905
symbol: thyA
gene_biotype: protein_coding
description:
  Thymidylate synthetase (thyA); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.


ensembl_gene_id: HI_0906
symbol: tadA
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family.


ensembl_gene_id: HI_0909
symbol: secA
gene_biotype: protein_coding
description:
  Preprotein translocase SecA subunit (secA); Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. Belongs to the SecA family.


ensembl_gene_id: HI_0910
symbol: mutT
gene_biotype: protein_coding
description:
  Mutator mutT protein (mutT); Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal efficiency thus leading to A.T to G.C transversions. MutT specifically degrades 8-oxo-dGTP to the monophosphate (By similarity); Belongs to the Nudix hydrolase family.


ensembl_gene_id: HI_0911
symbol: kefBC
gene_biotype: protein_coding
description:
  Glutathione-regulated potassium efflux system protein (kefC); Transport system that facilitate potassium-efflux, possibly by potassium-proton antiport; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family.


ensembl_gene_id: HI_0913
symbol: rpsB
gene_biotype: protein_coding
description:
  Ribosomal protein S2 (rpS2); Similar to GB:D26562 SP:P02351 GB:V00343 PID:42842 PID:473824 percent identity: 82.16; identified by sequence similarity; putative; Belongs to the universal ribosomal protein uS2 family.


ensembl_gene_id: HI_0914
symbol: tsf
gene_biotype: protein_coding
description:
  Elongation factor Ts (tsf); Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity); Belongs to the EF-Ts family.


ensembl_gene_id: HI_0915
symbol: lpxD
gene_biotype: protein_coding
description:
  UDP-3-O-(3-hydroxymyristoyl)-glucosamine N-acyltransferase (lpxD); Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily.


ensembl_gene_id: HI_0916
symbol: omp26
gene_biotype: protein_coding
description:
  Outer membrane protein, putative; Similar to PID:1935023 percent identity: 37.58; identified by sequence similarity; putative.


ensembl_gene_id: HI_0917
symbol: bamA
gene_biotype: protein_coding
description:
  Protective surface antigen D15; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.


ensembl_gene_id: HI_0918
symbol: rsep
gene_biotype: protein_coding
description:
  Conserved hypothetical transmembrane protein; A site-2 regulated intramembrane protease (S2P) that cleaves a peptide bond in the transmembrane region of RseA. Part of a regulated intramembrane proteolysis (RIP) cascade. Acts on DegS-cleaved RseA to release the cytoplasmic domain of RseA. This provides the cell with sigma-E (RpoE) activity through the proteolysis of RseA (By similarity); Belongs to the peptidase M50B family.


ensembl_gene_id: HI_0919
symbol: cdsA
gene_biotype: protein_coding
description:
  CDP-diglyceride synthetase (cdsA); Similar to GB:M11330 SP:P06466 PID:1208947 PID:145476 GB:U00096 percent identity: 48.39; identified by sequence similarity; putative.


ensembl_gene_id: HI_0920
symbol: uppS
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di- trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide.


ensembl_gene_id: HI_0921
symbol: leuS
gene_biotype: protein_coding
description:
  leucyl-tRNA synthetase (leuS); Similar to SP:P07813 GB:X06331 PID:41916 GB:U00096 PID:1651269 percent identity: 72.64; identified by sequence similarity; putative; Belongs to the class-I aminoacyl-tRNA synthetase family.


ensembl_gene_id: HI_0922
symbol: lptE
gene_biotype: protein_coding
description:
  Rare lipoprotein B, putative; Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane.


ensembl_gene_id: HI_0923
symbol: holA
gene_biotype: protein_coding
description:
  DNA polymerase III, delta subunit (holA); DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The delta subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA (By similarity).


ensembl_gene_id: HI_0924
symbol: glyS
gene_biotype: protein_coding
description:
  glycyl-tRNA synthetase, beta chain (glyS); Similar to SP:P00961 GB:J01622 PID:146223 PID:466697 GB:U00096 percent identity: 69.67; identified by sequence similarity; putative.


ensembl_gene_id: HI_0925
symbol: HI_0925
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to SP:P45736 GB:U00096 PID:1279405 PID:1787546 percent identity: 41.75; identified by sequence similarity; putative; To E.coli YcjD and H.influenzae HI_1162.


ensembl_gene_id: HI_0927
symbol: glyQ
gene_biotype: protein_coding
description:
  glycyl-tRNA synthetase, alpha chain (glyQ); Similar to SP:P00960 GB:J01622 PID:146222 PID:146225 PID:466698 percent identity: 90.64; identified by sequence similarity; putative.


ensembl_gene_id: HI_0928
symbol: katA
gene_biotype: protein_coding
description:
  Catalase (hktE); Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide; Belongs to the catalase family.


ensembl_gene_id: HI_0929
symbol: HI_0929
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; May be a ligase forming an amide bond. Shows ATPase activity (By similarity).


ensembl_gene_id: HI_0932
symbol: eno
gene_biotype: protein_coding
description:
  Enolase (eno); Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.


ensembl_gene_id: HI_0933
symbol: HI_0933
gene_biotype: protein_coding
description:
  Conserved hypothetical transmembrane protein; Similar to SP:P37631 PID:912464 GB:U00096 PID:2367234 percent identity: 58.35; identified by sequence similarity; putative; To E.coli YhiN.


ensembl_gene_id: HI_0934
symbol: nrfF
gene_biotype: protein_coding
description:
  Cytochrome C-type biogenesis protein (nrfF); Possible subunit of a heme lyase; Belongs to the CcmH/CycL/Ccl2/NrfF family.


ensembl_gene_id: HI_0935
symbol: nrfX
gene_biotype: protein_coding
description:
  Thiol:disulfide interchange protein (dsbE); Could be involved in disulfide bond formation. Could catalyzes a late, reductive step in the assembly of periplasmic NrfA c- type cytochrome, probably the reduction of disulfide bonds of the apocytochrome c to allow covalent linkage with the heme. Possible subunit of a heme lyase; Belongs to the thioredoxin family. DsbE subfamily.


ensembl_gene_id: HI_0936
symbol: nrfE
gene_biotype: protein_coding
description:
  Cytochrome C-type biogenesis; Required for the biogenesis of c-type cytochromes. Possible subunit of a heme lyase (By similarity); Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.


ensembl_gene_id: HI_0937
symbol: suhB
gene_biotype: protein_coding
description:
  Extragenic suppressor (suhB); Similar to GB:M34828 SP:P22783 PID:147899 GB:U00096 PID:1788882 percent identity: 65.12; identified by sequence similarity; putative; Belongs to the inositol monophosphatase superfamily.


ensembl_gene_id: HI_0942
symbol: recC
gene_biotype: protein_coding
description:
  Exodeoxyribonuclease V, gamma chain (recC); A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination  [...]


ensembl_gene_id: HI_0943
symbol: nrdR
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family.


ensembl_gene_id: HI_0944
symbol: ribD
gene_biotype: protein_coding
description:
  Riboflavin biosynthesis protein (ribD); Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.


ensembl_gene_id: HI_0945
symbol: degS
gene_biotype: protein_coding
description:
  Protease (degS); A site-1 protease (S1P) that cleaves the peptide bond between 'Val-148' and 'Ser-149' in RseA. Part of a regulated intramembrane proteolysis (RIP) cascade. When heat shock or other environmental stresses disrupt protein folding in the periplasm, DegS senses the accumulation of unassembled outer membrane porins (OMP) and then initiates RseA (anti sigma-E factor) degradation by cleaving its periplasmic domain, making it a substrate for subsequent cleavage by RseP. This cascade ultimately leads to the sigma-E-driven expression of a variety of factors dealing with folding  [...]


ensembl_gene_id: HI_0946
symbol: mutM
gene_biotype: protein_coding
description:
  formamidopyrimidine-DNA glycosylase (fpg); Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity).


ensembl_gene_id: HI_0946.1
symbol: ddc
gene_biotype: protein_coding
description:
  L-2,4-diaminobutyrate decarboxylase; Similar to PID:893355 percent identity: 75.54; identified by sequence similarity; putative.


ensembl_gene_id: HI_0947
symbol: vapC2
gene_biotype: protein_coding
description:
  Virulence associated protein C (vapC); Toxic component of a type II toxin-antitoxin (TA) system. An RNase. Its cognate antitoxin is VapB2 (By similarity). Belongs to the PINc/VapC protein family.


ensembl_gene_id: HI_0948
symbol: vapB2
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Antitoxin component of a type II toxin-antitoxin (TA) system. Neutralizes the effect of toxin VapC2 (By similarity).


ensembl_gene_id: HI_0949
symbol: dat
gene_biotype: protein_coding
description:
  Aminotransferase; Similar to PID:2340815 percent identity: 71.85; identified by sequence similarity; putative.


ensembl_gene_id: HI_0950
symbol: rpmG
gene_biotype: protein_coding
description:
  Ribosomal protein L33 (rpL33); Similar to GB:J01677 SP:P02436 PID:147709 PID:290486 GB:U00096 percent identity: 81.48; identified by sequence similarity; putative; Belongs to the bacterial ribosomal protein bL33 family.


ensembl_gene_id: HI_0951
symbol: rpmB
gene_biotype: protein_coding
description:
  Ribosomal protein L28 (rpL28); Similar to GB:J01677 SP:P02428 PID:147708 PID:290487 GB:U00096 percent identity: 85.71; identified by sequence similarity; putative; Belongs to the bacterial ribosomal protein bL28 family.


ensembl_gene_id: HI_0952
symbol: HI_0952
gene_biotype: protein_coding
description:
  DNA repair protein (radC); Similar to GB:L10328 SP:P25531 GB:X63366 GB:X63367 PID:290488 percent identity: 49.77; identified by sequence similarity; putative; Belongs to the UPF0758 family.


ensembl_gene_id: HI_0953
symbol: coaBC
gene_biotype: protein_coding
description:
  DNA/pantothenate metabolism flavoprotein (dfp); Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'- phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'- phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family.


ensembl_gene_id: HI_0954
symbol: dut
gene_biotype: protein_coding
description:
  Deoxyuridinetriphosphatase (dut); This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family.


ensembl_gene_id: HI_0955
symbol: slmA
gene_biotype: protein_coding
description:
  Transcriptional regulator (ttk); Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions.


ensembl_gene_id: HI_0956
symbol: HI_0956
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to SP:P45536 PID:606288 GB:U00096 PID:1789753 percent identity: 50.70; identified by sequence similarity; putative; Belongs to the UPF0270 family.


ensembl_gene_id: HI_0957
symbol: crp
gene_biotype: protein_coding
description:
  Catabolite gene activator (crp); A global transcription regulator required for bacterial competence. Complexes with cyclic AMP (cAMP) which allosterically activates DNA binding (to consensus sequence 5'-AAATGTGATCTAGATCACATTT- 3') to regulate transcription at 54 promoters. There are 2 consensus subclasses; CRP-N (above) and CRP-S (T6 changed to C and A17 changed to G) which obligatorily also requires Sxy for expression. CRP-S sites bind DNA but do not activate transcription in the absence of Sxy. Probably induces a severe bend in DNA. Probably acts as a negative regulator of its own sy [...]


ensembl_gene_id: HI_0958
symbol: rlmC
gene_biotype: protein_coding
description:
  RNA methyltransferase, putative; Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmC subfamily.


ensembl_gene_id: HI_0959
symbol: nagZ
gene_biotype: protein_coding
description:
  Beta-hexosaminidase (exoII); Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides.


ensembl_gene_id: HI_0961
symbol: HI_0961
gene_biotype: protein_coding
description:
  Hit-related protein; Hydrolyzes purine nucleotide phosphoramidates, including adenosine 5'monophosphoramidate (AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate), guanosine 5'monophosphomorpholidate (GMP-morpholidate) and tryptamine 5'guanosine monophosphate (TpGd). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha- acetyl lysine methyl ester)) generated by lysine tRNA ligase and lysyl- GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)). Belongs to the HINT family.


ensembl_gene_id: HI_0963
symbol: ribF
gene_biotype: protein_coding
description:
  Riboflavin kinase / FMN adenylyltransferase (ribF); Catalyzes the phosphorylation of riboflavin to FMN followed by the adenylation of FMN to FAD.


ensembl_gene_id: HI_0964
symbol: murJ
gene_biotype: protein_coding
description:
  Virulence factor (mviN); Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.


ensembl_gene_id: HI_0968
symbol: menB
gene_biotype: protein_coding
description:
  Naphthoate synthase (menB); Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA).


ensembl_gene_id: HI_0969
symbol: menC
gene_biotype: protein_coding
description:
  O-succinylbenzoate-CoA synthase (menC); Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB).


ensembl_gene_id: HI_0970
symbol: aroQ
gene_biotype: protein_coding
description:
  3-dehydroquinase (aroQ); Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family.


ensembl_gene_id: HI_0971
symbol: accB
gene_biotype: protein_coding
description:
  acetyl-CoA carboxylase, biotin carboxyl carrier protein (accB); This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.


ensembl_gene_id: HI_0972
symbol: accC
gene_biotype: protein_coding
description:
  acetyl-CoA carboxylase, biotin carboxylase (accC); This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.


ensembl_gene_id: HI_0974.1
symbol: HI_0974.1
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to SP:P45566 PID:606197 GB:U00096 PID:1789655 percent identity: 46.15; identified by sequence similarity; putative.


ensembl_gene_id: HI_0975
symbol: panF
gene_biotype: protein_coding
description:
  Sodium/pantothenate symporter (panF); Catalyzes the sodium-dependent uptake of extracellular pantothenate; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.


ensembl_gene_id: HI_0976
symbol: HI_0976
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:AL009126 percent identity: 25.21; identified by sequence similarity; putative.


ensembl_gene_id: HI_0976.1
symbol: HI_0976.1
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:AL009126 percent identity: 24.90; identified by sequence similarity; putative.


ensembl_gene_id: HI_0977
symbol: HI_0977
gene_biotype: protein_coding
description:
  Cell filamentation protein (fic); Probable adenylyltransferase that mediates the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins.


ensembl_gene_id: HI_0978
symbol: prmA
gene_biotype: protein_coding
description:
  Ribosomal protein L11 methyltransferase (prmA); Methylates ribosomal protein L11; Belongs to the methyltransferase superfamily. PrmA family.


ensembl_gene_id: HI_0979
symbol: dusB
gene_biotype: protein_coding
description:
  Nitrogen fixation protein (nifR3); Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the Dus family. DusB subfamily.


ensembl_gene_id: HI_0980
symbol: fis
gene_biotype: protein_coding
description:
  Hin recombinational enhancer binding protein (fis); Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters; Belongs to the transcriptional regulatory Fis family.


ensembl_gene_id: HI_0981
symbol: smpB
gene_biotype: protein_coding
description:
  Small protein B (smpB); Required for rescue of stalled ribosomes mediated by trans- translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches  [...]


ensembl_gene_id: HI_0982
symbol: pfkA
gene_biotype: protein_coding
description:
  6-phosphofructokinase (pfkA); Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.


ensembl_gene_id: HI_0984
symbol: HI_0984
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:D10483 SP:P11288 PID:216438 PID:537248 PID:1128976 percent identity: 62.20; identified by sequence similarity; putative; Belongs to the UPF0246 family.


ensembl_gene_id: HI_0985
symbol: dprA
gene_biotype: protein_coding
description:
  DNA processing chain A (dprA); Essential for efficient chromosomal DNA transformation but not required for plasmid transformation. Its disruption can be partially complemented by the smf gene of E.coli ; Belongs to the DprA/Smf family.


ensembl_gene_id: HI_0986
symbol: leuA
gene_biotype: protein_coding
description:
  2-isopropylmalate synthase (leuA); Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.


ensembl_gene_id: HI_0987
symbol: leuB
gene_biotype: protein_coding
description:
  3-isopropylmalate dehydrogenase (beta-IPM dehydrogenase) (leuB); Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity); Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.


ensembl_gene_id: HI_0988
symbol: leuC
gene_biotype: protein_coding
description:
  3-isopropylmalate dehydratase, alpha subunit (leuC); Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.


ensembl_gene_id: HI_0989
symbol: leuD
gene_biotype: protein_coding
description:
  3-isopropylmalate dehydratase small subunit (leuD); Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.


ensembl_gene_id: HI_0990
symbol: iga
gene_biotype: protein_coding
description:
  Immunoglobin A1 protease (iga1); Virulence factor; cleaves host immunoglobulin A producing intact Fc and Fab fragments.


ensembl_gene_id: HI_0991
symbol: recF
gene_biotype: protein_coding
description:
  DNA/ATP binding protein (recF); The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity).


ensembl_gene_id: HI_0992
symbol: dnaN
gene_biotype: protein_coding
description:
  DNA polymerase III, beta subunit (dnaN); Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initia [...]


ensembl_gene_id: HI_0993
symbol: dnaA
gene_biotype: protein_coding
description:
  Chromosomal replication initiator protein (dnaA); Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity).


ensembl_gene_id: HI_0994
symbol: tbpA
gene_biotype: protein_coding
description:
  Transferrin-binding protein 1 precursor (tbp1); Acts as a transferrin receptor and is required for transferrin utilization; Belongs to the TonB-dependent receptor family.


ensembl_gene_id: HI_0995
symbol: tbpB
gene_biotype: protein_coding
description:
  Transferrin-binding protein 2 precursor (tbp2); Acts as a transferrin receptor and is required for transferrin utilization.


ensembl_gene_id: HI_0998
symbol: rpmH
gene_biotype: protein_coding
description:
  Ribosomal protein L34 (rpL34); Similar to GB:L10328 SP:P02437 GB:J01602 GB:M11056 PID:145759 percent identity: 86.36; identified by sequence similarity; putative; Belongs to the bacterial ribosomal protein bL34 family.


ensembl_gene_id: HI_0999
symbol: rnpA
gene_biotype: protein_coding
description:
  Ribonuclease P (rnpA); RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.


ensembl_gene_id: HI_1000
symbol: HI_1000
gene_biotype: protein_coding
description:
  Hemolysin, putative; Could be involved in insertion of integral membrane proteins into the membrane; Belongs to the UPF0161 family.


ensembl_gene_id: HI_1001
symbol: yidC
gene_biotype: protein_coding
description:
  Inner membrane protein, 60 kDa (yidC); Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.


ensembl_gene_id: HI_1002
symbol: mnmE
gene_biotype: protein_coding
description:
  Thiophene and furan oxidation protein (thdF); Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.


ensembl_gene_id: HI_1004
symbol: ppiD
gene_biotype: protein_coding
description:
  Peptidyl-prolyl cis-trans isomerse, putative; PPIases accelerate the folding of proteins. Seems to be involved in the folding of outer membrane proteins (By similarity).


ensembl_gene_id: HI_1005
symbol: HI_1005
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:U00096 SP:P75785 PID:1787035 percent identity: 33.76; identified by sequence similarity; putative.


ensembl_gene_id: HI_1006
symbol: lspA
gene_biotype: protein_coding
description:
  Lipoprotein signal peptidase (lspA); This protein specifically catalyzes the removal of signal peptides from prolipoproteins; Belongs to the peptidase A8 family.


ensembl_gene_id: HI_1007
symbol: ispH
gene_biotype: protein_coding
description:
  Penicillin tolerance protein (lytB); Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family.


ensembl_gene_id: HI_1008
symbol: HI_1008
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:U00096 SP:P77415 PID:1580713 PID:1773126 PID:1786646 percent identity: 37.04; identified by sequence similarity; putative.


ensembl_gene_id: HI_1009
symbol: HI_1009
gene_biotype: protein_coding
description:
  Glycerol-3-phosphate regulon repressor (glpR); Similar to SP:P09392 GB:M96795 PID:146186 PID:606358 GB:U00096 percent identity: 29.37; identified by sequence similarity; putative.


ensembl_gene_id: HI_1010
symbol: ltnD
gene_biotype: protein_coding
description:
  3-hydroxyisobutyrate dehydrogenase, putative; Catalyzes oxidation of L-threonate to 2-oxo-tetronate. Can use either NAD(+) or NADP(+) as cosubstrate, with a preference for NAD(+).


ensembl_gene_id: HI_1011
symbol: otnK
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Catalyzes the ATP-dependent phosphorylation of 3-oxo- tetronate to 3-oxo-tetronate 4-phosphate.


ensembl_gene_id: HI_1012
symbol: otnC
gene_biotype: protein_coding
description:
  Sugar isomerase, putative; Catalyzes the decarboxylation of 3-oxo-tetronate 4-phosphate to dihydroxyacetone phosphate (DHAP) and CO(2). Belongs to the aldolase class II family. AraD/FucA subfamily.


ensembl_gene_id: HI_1014
symbol: denD
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Catalyzes oxidation of D-erythronate to 2-oxo-tetronate. Can use either NAD(+) or NADP(+) as cosubstrate, with a preference for NAD(+).


ensembl_gene_id: HI_1015
symbol: HI_1015
gene_biotype: protein_coding
description:
  Gluconate permease (gntP); Similar to SP:P39835 PID:606350 GB:U00096 PID:1789820 percent identity: 32.35; identified by sequence similarity; putative.


ensembl_gene_id: HI_1017
symbol: HI_1017
gene_biotype: protein_coding
description:
  Glycerol uptake facilitator protein (glpF); Similar to GB:M99611 SP:P18156 PID:142991 PID:142997 PID:2226136 percent identity: 41.28; identified by sequence similarity; putative; Belongs to the MIP/aquaporin (TC 1.A.8) family.


ensembl_gene_id: HI_1019
symbol: thiB
gene_biotype: protein_coding
description:
  Thiamin ABC transporter, periplasmic-binding protein (tbpA); Part of the ABC transporter complex ThiBPQ involved in thiamine import.


ensembl_gene_id: HI_1020
symbol: thiP
gene_biotype: protein_coding
description:
  Thiamin ABC transporter, permease protein, putative; Part of the ABC transporter complex ThiBPQ involved in thiamine import. Probably responsible for the translocation of the substrate across the membrane.


ensembl_gene_id: HI_1021
symbol: thiQ
gene_biotype: protein_coding
description:
  Thiamin ABC transporter, ATP-binding protein, putative; Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Thiamine importer (TC 3.A.1.19.1) family.


ensembl_gene_id: HI_1022
symbol: bioB
gene_biotype: protein_coding
description:
  Biotin synthetase (bioB); Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family.


ensembl_gene_id: HI_1023
symbol: tktA
gene_biotype: protein_coding
description:
  Transketolase 1 (tktA); Catalyzes the reversible transfer of a two-carbon ketol group from sedoheptulose-7-phosphate to glyceraldehyde-3-phosphate, producing xylulose-5-phosphate and ribose-5-phosphate. Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate (By similarity).


ensembl_gene_id: HI_1024
symbol: sgbH
gene_biotype: protein_coding
description:
  Hexulose-6-phosphate synthase, putative; Catalyzes the decarboxylation of 3-keto-L-gulonate-6-P into L-xylulose-5-P; Belongs to the HPS/KGPDC family. KGPDC subfamily.


ensembl_gene_id: HI_1025
symbol: sgbE
gene_biotype: protein_coding
description:
  L-ribulose-5-phosphate 4-epimerase (araD); Catalyzes the interconversion of L-ribulose 5-phosphate (LRu5P) and D-xylulose 5-phosphate (D-Xu5P) via a retroaldol/aldol mechanism (carbon-carbon bond cleavage analogous to a class II aldolase reaction). May be involved in the utilization of 2,3-diketo-L-gulonate.


ensembl_gene_id: HI_1026
symbol: sgbU
gene_biotype: protein_coding
description:
  Hexulose-6-phosphate isomerase, putative; Catalyzes the isomerization of L-xylulose-5-phosphate to L- ribulose-5-phosphate.


ensembl_gene_id: HI_1027
symbol: lyx
gene_biotype: protein_coding
description:
  L-xylulose kinase (lyx); Similar to SP:P37677 PID:466718 GB:U00096 PID:1790005 percent identity: 53.93; identified by sequence similarity; putative; Belongs to the FGGY kinase family.


ensembl_gene_id: HI_1028
symbol: HI_1028
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to SP:P37676 PID:466717 GB:U00096 PID:1790004 percent identity: 55.80; identified by sequence similarity; putative.


ensembl_gene_id: HI_1029
symbol: HI_1029
gene_biotype: protein_coding
description:
  Conserved hypothetical transmembrane protein; Similar to SP:P37675 PID:466716 GB:U00096 PID:1790003 percent identity: 65.88; identified by sequence similarity; putative.


ensembl_gene_id: HI_1030
symbol: HI_1030
gene_biotype: protein_coding
description:
  Conserved hypothetical transmembrane protein; Similar to SP:P37674 PID:466715 GB:U00096 PID:1790002 percent identity: 37.50; identified by sequence similarity; putative.


ensembl_gene_id: HI_1031
symbol: dlgD
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Catalyzes the reduction of 2,3-diketo-L-gulonate in the presence of NADH, to form 3-keto-L-gulonate.


ensembl_gene_id: HI_1032
symbol: HI_1032
gene_biotype: protein_coding
description:
  Transcriptional regulator, putative; Similar to SP:P37671 PID:466712 GB:U00096 PID:1789999 percent identity: 63.74; identified by sequence similarity; putative.


ensembl_gene_id: HI_1034
symbol: HI_1034
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:U00096 SP:P77482 PID:1773110 PID:1786629 percent identity: 60.95; identified by sequence similarity; putative; Belongs to the UPF0234 family.


ensembl_gene_id: HI_1035
symbol: corA
gene_biotype: protein_coding
description:
  Magnesium and cobalt transport protein (corA); Mediates influx of magnesium ions. Can also mediate cobalt and manganese uptake (By similarity). Alternates between open and closed states. Activated by low cytoplasmic Mg(2+) levels. Inactive when cytoplasmic Mg(2+) levels are high (By similarity). Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.


ensembl_gene_id: HI_1036
symbol: HI_1036
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to PID:801880 SP:P52059 PID:801882 percent identity: 41.24; identified by sequence similarity; putative.


ensembl_gene_id: HI_1037
symbol: HI_1037
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to PID:984579 GB:U00096 SP:Q47147 PID:1552793 PID:1786417 percent identity: 47.45; identified by sequence similarity; putative.


ensembl_gene_id: HI_1038
symbol: HI_1038
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:L77117 PID:1592175 percent identity: 32.34; identified by sequence similarity; putative; To M.jannaschii MJ1544 and MJ1637.


ensembl_gene_id: HI_1040
symbol: hindVRP
gene_biotype: protein_coding
description:
  Type II restriction enzyme, putative; Similar to SP:P25261 SP:P24599 PID:43474 percent identity: 43.56; identified by sequence similarity; putative.


ensembl_gene_id: HI_1041
symbol: hindVM
gene_biotype: protein_coding
description:
  Modification methylase; This methylase recognizes the double-stranded sequence GRCGYC, causes specific methylation on C-? on both strands, and protects the DNA from cleavage by the HindV endonuclease; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.


ensembl_gene_id: HI_1043
symbol: HI_1043
gene_biotype: protein_coding
description:
  Ferredoxin-type protein (napF); Similar to SP:P33939 PID:453990 GB:U00096 PID:1736849 PID:1788536 percent identity: 33.08; identified by sequence similarity; putative.


ensembl_gene_id: HI_1044
symbol: dmsD
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Required for biogenesis/assembly of DMSO reductase, but not for the interaction of the DmsA signal peptide with the Tat system. May be part of a chaperone cascade complex that facilitates a folding- maturation pathway for the substrate protein.


ensembl_gene_id: HI_1045
symbol: dmsC
gene_biotype: protein_coding
description:
  Anaerobic dimethyl sulfoxide reductase, chain C (dmsC); Terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds. DmsC anchors the DmsAB dimer to the membrane and stabilizes it (By similarity).


ensembl_gene_id: HI_1046
symbol: dmsB
gene_biotype: protein_coding
description:
  Anaerobic dimethyl sulfoxide reductase, chain B (dmsB); Electron transfer subunit of the terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds.


ensembl_gene_id: HI_1047
symbol: dmsA
gene_biotype: protein_coding
description:
  Anaerobic dimethyl sulfoxide reductase, chain A (dmsA); Catalyzes the reduction of dimethyl sulfoxide (DMSO) to dimethyl sulfide (DMS). The terminal DMSO reductase can also use various sulfoxides and N-oxide compounds as terminal electron acceptor in addition to DMSO (By similarity); Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.


ensembl_gene_id: HI_1049
symbol: HI_1049
gene_biotype: protein_coding
description:
  Mercuric ion transport protein (merT); Similar to SP:P04140 GB:Z00027 PID:154899 PID:43716 percent identity: 25.00; identified by sequence similarity; putative.


ensembl_gene_id: HI_1050
symbol: HI_1050
gene_biotype: protein_coding
description:
  Mercuric ion scavenger protein (merP); Similar to PID:1143574 SP:Q54463 percent identity: 29.89; identified by sequence similarity; putative.


ensembl_gene_id: HI_1051
symbol: HI_1051
gene_biotype: protein_coding
description:
  ABC transporter, ATP-binding protein; Similar to GB:AL009126 percent identity: 33.76; identified by sequence similarity; putative.


ensembl_gene_id: HI_1052
symbol: HI_1052
gene_biotype: protein_coding
description:
  Transcriptional regulator, araC family, putative; Similar to SP:P35319 PID:581707 percent identity: 25.67; identified by sequence similarity; putative.


ensembl_gene_id: HI_1053
symbol: HI_1053
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:M66060 SP:P27749 PID:141897 percent identity: 31.86; identified by sequence similarity; putative.


ensembl_gene_id: HI_1054
symbol: HI_1054
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to PID:1381738 percent identity: 92.49; identified by sequence similarity; putative.


ensembl_gene_id: HI_1056
symbol: HI_1056
gene_biotype: protein_coding
description:
  Predicted coding region HI1056; Hypothetical protein; identified by GeneMark; putative; Belongs to the N(4)/N(6)-methyltransferase family.


ensembl_gene_id: HI_1059
symbol: rnhB
gene_biotype: protein_coding
description:
  Ribonuclease HII (rnhB); Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.


ensembl_gene_id: HI_1060
symbol: lpxB
gene_biotype: protein_coding
description:
  lipid-A-disaccharide synthetase (lpxB); Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.


ensembl_gene_id: HI_1061
symbol: lpxA
gene_biotype: protein_coding
description:
  UDP-N-acetylglucosamine acetyltransferase (lpxA); Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.


ensembl_gene_id: HI_1062
symbol: fabZ
gene_biotype: protein_coding
description:
  (3R)-hydroxymyristol (acyl carrier protein) dehydrase (fabZ); Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.


ensembl_gene_id: HI_1064
symbol: HI_1064
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:U00096 SP:P75785 PID:1787035 percent identity: 30.70; identified by sequence similarity; putative.


ensembl_gene_id: HI_1066
symbol: nrfD
gene_biotype: protein_coding
description:
  Nitrite reductase, transmembrane protein (nrfD); Probably involved in the transfer of electrons from the quinone pool to the type-c cytochromes; Belongs to the NrfD family.


ensembl_gene_id: HI_1067
symbol: nrfC
gene_biotype: protein_coding
description:
  Nitrite reductase, Fe-S protein (nrfC); Probably involved in the transfer of electrons from the quinone pool to the type-c cytochromes.


ensembl_gene_id: HI_1069
symbol: nrfA
gene_biotype: protein_coding
description:
  Nitrite reductase, cytochrome C552 (nrfA); Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process; Belongs to the cytochrome c-552 family.


ensembl_gene_id: HI_1070
symbol: hrpA
gene_biotype: protein_coding
description:
  ATP-dependent helicase (hrpa); Similar to SP:P43329 PID:806328 GB:U00096 PID:1742299 PID:1742304 percent identity: 70.29; identified by sequence similarity; putative.


ensembl_gene_id: HI_1073
symbol: HI_1073
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to SP:P32065 GB:U01030 GB:X73413 PID:312767 PID:523332 percent identity: 43.55; identified by sequence similarity; putative.


ensembl_gene_id: HI_1074
symbol: HI_1074
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:U00096 PID:1788090 percent identity: 51.37; identified by sequence similarity; putative.


ensembl_gene_id: HI_1075
symbol: HI_1075
gene_biotype: protein_coding
description:
  Cytochrome D ubiquinol oxidase, subunit II (cydB); Probable cytochrome oxidase subunit; Belongs to the cytochrome ubiquinol oxidase subunit 2 family.


ensembl_gene_id: HI_1077
symbol: pyrG
gene_biotype: protein_coding
description:
  CTP synthetase (pyrG); Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.


ensembl_gene_id: HI_1077.1
symbol: pnuC
gene_biotype: protein_coding
description:
  Predicted coding region HI1077.1; Required for nicotinamide riboside transport across the inner membrane.


ensembl_gene_id: HI_1078
symbol: HI_1078
gene_biotype: protein_coding
description:
  Amino acid ABC transporter, ATP-binding protein; Probably part of a binding-protein-dependent transport system for an amino acid. Probably responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily.


ensembl_gene_id: HI_1079
symbol: HI_1079
gene_biotype: protein_coding
description:
  Amino acid ABC transporter, permease protein; Probably part of a binding-protein-dependent transport system for an amino acid. Probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. HisMQ subfamily.


ensembl_gene_id: HI_1080
symbol: HI_1080
gene_biotype: protein_coding
description:
  Amino acid ABC transporter, periplasmic-binding protein; Probably part of a binding-protein-dependent transport system for an amino acid; Belongs to the bacterial solute-binding protein 3 family.


ensembl_gene_id: HI_1081
symbol: murA
gene_biotype: protein_coding
description:
  UDP-N-acetylglucosamine 1-carboxyvinyltransferase (murZ); Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily.


ensembl_gene_id: HI_1082
symbol: HI_1082
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to SP:P43781 PID:606128 GB:U00096 PID:1789581 percent identity: 46.51; identified by sequence similarity; putative; Belongs to the BolA/IbaG family.


ensembl_gene_id: HI_1083
symbol: mlaB
gene_biotype: protein_coding
description:
  Anti-sigma factor B antagonist, putative; Part of the ABC transporter complex MlaFEDB, which is involved in a phospholipid transport pathway that maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. MlaB plays critical roles in both the assembly and activity of the complex. May act by modulating MlaF structure and stability.


ensembl_gene_id: HI_1084
symbol: mlaC
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Involved in a phospholipid transport pathway that maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. May transfer phospholipid across the periplasmic space and deliver it to the MlaFEDB complex at the inner membrane. Belongs to the MlaC/ttg2D family.


ensembl_gene_id: HI_1085
symbol: mlaD
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Part of the ABC transporter complex MlaFEDB, which is involved in a phospholipid transport pathway that maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. MlaD functions in substrate binding with strong affinity for phospholipids and modulates ATP hydrolytic activity of the complex.


ensembl_gene_id: HI_1086
symbol: mlaE
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Part of the ABC transporter complex MlaFEDB, which is involved in a phospholipid transport pathway that maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. Probably responsible for the translocation of the substrate across the membrane.


ensembl_gene_id: HI_1087
symbol: mlaF
gene_biotype: protein_coding
description:
  ABC transporter, ATP-binding protein; Part of the ABC transporter complex MlaFEDB, which is involved in a phospholipid transport pathway that maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. Responsible for energy coupling to the transport system.


ensembl_gene_id: HI_1088
symbol: sodA
gene_biotype: protein_coding
description:
  Superoxide dismutase (sodA); Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the iron/manganese superoxide dismutase family.


ensembl_gene_id: HI_1089
symbol: ccmA
gene_biotype: protein_coding
description:
  Heme exporter ATP-binding protein A (ccmA); Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family.


ensembl_gene_id: HI_1090
symbol: ccmB
gene_biotype: protein_coding
description:
  Heme exporter protein B (ccmB); Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmB/CycW/HelB family.


ensembl_gene_id: HI_1091
symbol: ccmC
gene_biotype: protein_coding
description:
  Heme exporter protein C (ccmC); Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmC/CycZ/HelC family.


ensembl_gene_id: HI_1092
symbol: ccmD
gene_biotype: protein_coding
description:
  Heme exporter protein D (ccmD); Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmD/CycX/HelD family.


ensembl_gene_id: HI_1093
symbol: ccmE
gene_biotype: protein_coding
description:
  Cytochrome C-type biogenesis protein (ccmE); Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH. Belongs to the CcmE/CycJ family.


ensembl_gene_id: HI_1094
symbol: ccmF
gene_biotype: protein_coding
description:
  Cytochrome C-type biogenesis protein (ccmF); Required for the biogenesis of c-type cytochromes. Possible subunit of a heme lyase; Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.


ensembl_gene_id: HI_1095
symbol: dsbE
gene_biotype: protein_coding
description:
  Thiol:disulfide interchange protein (dsbE); Involved in disulfide bond formation. Catalyzes a late, reductive step in the assembly of periplasmic c-type cytochromes, probably the reduction of disulfide bonds of the apocytochrome c to allow covalent linkage with the heme. Possible subunit of a heme lyase (By similarity); Belongs to the thioredoxin family. DsbE subfamily.


ensembl_gene_id: HI_1100
symbol: ligA
gene_biotype: protein_coding
description:
  DNA ligase (lig); DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.


ensembl_gene_id: HI_1101
symbol: zipA
gene_biotype: protein_coding
description:
  Cell division protein ZipA, putative; Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins.


ensembl_gene_id: HI_1102
symbol: cysZ
gene_biotype: protein_coding
description:
  Cysteine synthetase, putative (cysZ); High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway; Belongs to the CysZ family.


ensembl_gene_id: HI_1103
symbol: cysK
gene_biotype: protein_coding
description:
  Cysteine synthetase (cysK); Similar to GB:M21451 SP:P11096 GB:X12615 PID:145686 PID:41201 percent identity: 70.65; identified by sequence similarity; putative; Belongs to the cysteine synthase/cystathionine beta- synthase family.


ensembl_gene_id: HI_1104
symbol: HI_1104
gene_biotype: protein_coding
description:
  Transporter protein; Similar to PID:1842056 percent identity: 29.56; identified by sequence similarity; putative.


ensembl_gene_id: HI_1105
symbol: rfaF
gene_biotype: protein_coding
description:
  ADP-heptose--LPS heptosyltransferase II (rfaF); Similar to SP:P37692 PID:466758 GB:U00096 PID:1790050 percent identity: 63.58; identified by sequence similarity; putative.


ensembl_gene_id: HI_1107
symbol: HI_1107
gene_biotype: protein_coding
description:
  Na+/H+ antiporter (nhaC); Similar to GB:M73530 SP:P27611 PID:143245 PID:2209268 percent identity: 37.50; identified by sequence similarity; putative.


ensembl_gene_id: HI_1109
symbol: xylH
gene_biotype: protein_coding
description:
  D-xylose ABC transporter, permease protein (xylH); Part of the binding-protein-dependent transport system for D- xylose. Probably responsible for the translocation of the substrate across the membrane (By similarity); Belongs to the binding-protein-dependent transport system permease family. AraH/RbsC subfamily.


ensembl_gene_id: HI_1110
symbol: xylG
gene_biotype: protein_coding
description:
  D-xylose ABC transporter, ATP-binding protein (xylG); Part of the ABC transporter complex XylFGH involved in xylose import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Xylose importer (TC 3.A.1.2.4) family.


ensembl_gene_id: HI_1111
symbol: xylF
gene_biotype: protein_coding
description:
  D-xylose ABC transporter, periplasmic-binding protein (xylF); Involved in the high-affinity D-xylose membrane transport system. Binds with high affinity to xylose (By similarity). Belongs to the bacterial solute-binding protein 2 family.


ensembl_gene_id: HI_1112
symbol: xylA
gene_biotype: protein_coding
description:
  Xylose isomerase (xylA); Similar to GB:X04691 SP:P00944 GB:K01996 GB:S68257 PID:148279 percent identity: 71.30; identified by sequence similarity; putative; Belongs to the xylose isomerase family.


ensembl_gene_id: HI_1113
symbol: xylB
gene_biotype: protein_coding
description:
  Xylulose kinase; Catalyzes the phosphorylation of D-xylulose to D-xylulose 5- phosphate; Belongs to the FGGY kinase family.


ensembl_gene_id: HI_1114
symbol: hldD
gene_biotype: protein_coding
description:
  ADP-L-glycero-D-mannoheptose-6-epimerase (rfaD); Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.


ensembl_gene_id: HI_1115
symbol: HI_1115
gene_biotype: protein_coding
description:
  Thioredoxin, putative; Similar to PID:1213065 SP:P52229 percent identity: 36.36; identified by sequence similarity; putative.


ensembl_gene_id: HI_1116
symbol: deoC
gene_biotype: protein_coding
description:
  Deoxyribose-phosphate aldolase (deoC); Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.


ensembl_gene_id: HI_1117
symbol: comM
gene_biotype: protein_coding
description:
  Competence protein (comM); Induced during competence development. Not needed for DNA uptake. May be involved in a recombination step.


ensembl_gene_id: HI_1118
symbol: engB
gene_biotype: protein_coding
description:
  Conserved hypothetical GTP-binding protein; Necessary for normal cell division and for the maintenance of normal septation; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.


ensembl_gene_id: HI_1119
symbol: HI_1119
gene_biotype: protein_coding
description:
  Membrane protein (lapB); Similar to SP:P32181 GB:M59210 PID:387858 percent identity: 63.13; identified by sequence similarity; putative.


ensembl_gene_id: HI_1120
symbol: oppF
gene_biotype: protein_coding
description:
  Oligopeptide ABC transporter, ATP-binding protein (oppF); Part of the binding-protein-dependent transport system for oligopeptides. Probably responsible for energy coupling to the transport system (By similarity); Belongs to the ABC transporter superfamily.


ensembl_gene_id: HI_1121
symbol: oppD
gene_biotype: protein_coding
description:
  Oligopeptide ABC transporter, ATP-binding protein (oppD); Part of the binding-protein-dependent transport system for oligopeptides. Probably responsible for energy coupling to the transport system (By similarity); Belongs to the ABC transporter superfamily.


ensembl_gene_id: HI_1122
symbol: oppC
gene_biotype: protein_coding
description:
  Oligopeptide ABC transporter, permease protein (oppC); Part of the binding-protein-dependent transport system for oligopeptides; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily.


ensembl_gene_id: HI_1123
symbol: oppB
gene_biotype: protein_coding
description:
  Oligopeptide ABC transporter, permease protein (oppB); Part of the binding-protein-dependent transport system for oligopeptides; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily.


ensembl_gene_id: HI_1124
symbol: oppA
gene_biotype: protein_coding
description:
  Oligopeptide ABC transporter, periplasmic-binding protein (oppA); This protein is a component of the oligopeptide permease, a binding protein-dependent transport system, it binds peptides up to five amino acids long with high affinity; Belongs to the bacterial solute-binding protein 5 family.


ensembl_gene_id: HI_1125
symbol: tal
gene_biotype: protein_coding
description:
  Transaldolase B (talB); Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.


ensembl_gene_id: HI_1129
symbol: mraZ
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to SP:P22186 GB:X52063 PID:40849 PID:42319 GB:U00096 percent identity: 59.21; identified by sequence similarity; putative; Belongs to the MraZ family.


ensembl_gene_id: HI_1130
symbol: rsmH
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.


ensembl_gene_id: HI_1131
symbol: ftsL
gene_biotype: protein_coding
description:
  Cell division protein (ftsL); Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.


ensembl_gene_id: HI_1132
symbol: ftsI
gene_biotype: protein_coding
description:
  Penicillin-binding protein 3 (ftsI); Catalyzes cross-linking of the peptidoglycan cell wall at the division septum; Belongs to the transpeptidase family. FtsI subfamily.


ensembl_gene_id: HI_1133
symbol: murE
gene_biotype: protein_coding
description:
  UDP-N-acetylmuramyl-tripeptide synthetase (murE); Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily.


ensembl_gene_id: HI_1134
symbol: murF
gene_biotype: protein_coding
description:
  UDP-MurNAc-pentapeptide synthetase (murF); Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily.


ensembl_gene_id: HI_1135
symbol: mraY
gene_biotype: protein_coding
description:
  phospho-N-acetylmuramoyl-pentapeptide- transferase E (mraY); First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily.


ensembl_gene_id: HI_1136
symbol: murD
gene_biotype: protein_coding
description:
  UDP-N-acetylmuramoylalanine--D-glutamate ligase (murD); Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family.


ensembl_gene_id: HI_1137
symbol: ftsW
gene_biotype: protein_coding
description:
  Cell division protein (ftsW); Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily.


ensembl_gene_id: HI_1138
symbol: murG
gene_biotype: protein_coding
description:
  Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily.


ensembl_gene_id: HI_1141
symbol: ftsQ
gene_biotype: protein_coding
description:
  Cell division protein (ftsQ); Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly.


ensembl_gene_id: HI_1142
symbol: ftsA
gene_biotype: protein_coding
description:
  Cell division protein (ftsA); Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.


ensembl_gene_id: HI_1143
symbol: ftsZ
gene_biotype: protein_coding
description:
  Cell division protein (ftsZ); Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.


ensembl_gene_id: HI_1144
symbol: lpxC
gene_biotype: protein_coding
description:
  UDP-3-0-(3-hydroxymyristoyl) N-acetylglucosamine deacetylase (lpxC); Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family.


ensembl_gene_id: HI_1145
symbol: pheA
gene_biotype: protein_coding
description:
  Chorismate mutase / prephenate dehydratase (pheA); Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.


ensembl_gene_id: HI_1147
symbol: ptsN
gene_biotype: protein_coding
description:
  Nitrogen regulatory IIA protein (ptsN); Not known; lacks the phosphorylation site found in other PtsN proteins.


ensembl_gene_id: HI_1148
symbol: lptB
gene_biotype: protein_coding
description:
  ABC transporter, ATP-binding protein; Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. Probably responsible for energy coupling to the transport system (By similarity).


ensembl_gene_id: HI_1149
symbol: lptA
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm.


ensembl_gene_id: HI_1150
symbol: lptC
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA.


ensembl_gene_id: HI_1151
symbol: HI_1151
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to SP:P26650 GB:M95096 PID:148266 PID:537076 GB:U00096 percent identity: 62.20; identified by sequence similarity; putative; Belongs to the UPF0307 family.


ensembl_gene_id: HI_1153
symbol: hpt
gene_biotype: protein_coding
description:
  Hypoxanthine phosphoribosyltransferase (hpt); Acts preferentially on hypoxanthine; has very low activity towards guanine. Inactive towards xanthine (By similarity). Belongs to the purine/pyrimidine phosphoribosyltransferase family.


ensembl_gene_id: HI_1154
symbol: HI_1154
gene_biotype: protein_coding
description:
  Proton glutamate symport protein, putative; Similar to GB:U00096 PID:1742823 PID:1742828 PID:1788024 percent identity: 55.98; identified by sequence similarity; putative.


ensembl_gene_id: HI_1155
symbol: nrdG
gene_biotype: protein_coding
description:
  Anaerobic ribonucleoside-triphosphate reductase activating protein (nrdG); Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family.


ensembl_gene_id: HI_1156
symbol: cydC
gene_biotype: protein_coding
description:
  Transport ATP-binding protein (cydC); Somehow involved in the cytochrome D branch of aerobic respiration. Seems to be a component of a transport system (By similarity); Belongs to the ABC transporter superfamily. Cysteine exporter (TC 3.A.1.129.1) family.


ensembl_gene_id: HI_1157
symbol: cydD
gene_biotype: protein_coding
description:
  ATP-binding protein protein (cydD); Somehow involved in the cytochrome D branch of aerobic respiration. Seems to be a component of a transport system (By similarity); Belongs to the ABC transporter superfamily. Cysteine exporter (TC 3.A.1.129.1) family.


ensembl_gene_id: HI_1158
symbol: trxB
gene_biotype: protein_coding
description:
  Thioredoxin reductase (trxB); Similar to GB:J03762 SP:P09625 PID:148073 PID:347239 GB:U00096 percent identity: 75.95; identified by sequence similarity; putative.


ensembl_gene_id: HI_1159
symbol: HI_1159
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:U00096 SP:P77395 PID:1773174 PID:1786700 percent identity: 50.89; identified by sequence similarity; putative.


ensembl_gene_id: HI_1160
symbol: hemH
gene_biotype: protein_coding
description:
  Ferrochelatase (hemH); Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.


ensembl_gene_id: HI_1161
symbol: HI_1161
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:M24143 SP:P15050 PID:450383 PID:522184 GB:U00096 percent identity: 49.26; identified by sequence similarity; putative; Belongs to the thioesterase PaaI family.


ensembl_gene_id: HI_1162
symbol: HI_1162
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to SP:P45736 GB:U00096 PID:1279405 PID:1787546 percent identity: 42.86; identified by sequence similarity; putative; To E.coli YcjD and H.influenzae HI_0925.


ensembl_gene_id: HI_1163
symbol: HI_1163
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:U00096 SP:P77748 PID:1742760 PID:1787977 percent identity: 60.82; identified by sequence similarity; putative.


ensembl_gene_id: HI_1164
symbol: ompA
gene_biotype: protein_coding
description:
  Outer membrane protein P5 (ompA); With TolR probably plays a role in maintaining the position of the peptidoglycan cell wall in the periplasm. Acts as a porin with low permeability that allows slow penetration of small solutes; an internal gate slows down solute passage; Belongs to the outer membrane OOP (TC 1.B.6) superfamily. OmpA family.


ensembl_gene_id: HI_1165
symbol: grxD
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Monothiol glutaredoxin involved in the biogenesis of iron- sulfur clusters.


ensembl_gene_id: HI_1166
symbol: hisC2
gene_biotype: protein_coding
description:
  Histidinol-phosphate aminotransferase (hisH); Similar to SP:P17731 PID:143814 GB:AL009126 percent identity: 38.70; identified by sequence similarity; putative; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.


ensembl_gene_id: HI_1167
symbol: serC
gene_biotype: protein_coding
description:
  Phosphoserine aminotransferase (serC); Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.


ensembl_gene_id: HI_1168
symbol: HI_1168
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:U00096 PID:1788317 percent identity: 56.14; identified by sequence similarity; putative; Belongs to the UPF0265 family.


ensembl_gene_id: HI_1170
symbol: HI_1170
gene_biotype: protein_coding
description:
  Predicted coding region HI1170; Hypothetical protein; identified by GeneMark; putative; To the C-terminal of para-aminobenzoate synthase component I.


ensembl_gene_id: HI_1171
symbol: HI_1171
gene_biotype: protein_coding
description:
  Anthranilate synthase component II (trpG); Similar to GB:M36636 SP:P00902 PID:141800 percent identity: 34.04; identified by sequence similarity; putative.


ensembl_gene_id: HI_1172
symbol: metK
gene_biotype: protein_coding
description:
  S-adenosylmethionine synthetase (metX); Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.


ensembl_gene_id: HI_1173
symbol: sprT
gene_biotype: protein_coding
description:
  Sprt protein (sprT); Similar to SP:P39902 PID:1208420 PID:882473 GB:U00096 PID:1789313 percent identity: 46.00; identified by sequence similarity; putative; Belongs to the SprT family.


ensembl_gene_id: HI_1174
symbol: opa
gene_biotype: protein_coding
description:
  Opacity protein, putative; Similar to GB:X15780 PID:1333789 percent identity: 38.76; identified by sequence similarity; putative; Belongs to the opacity porin family.


ensembl_gene_id: HI_1177
symbol: artM
gene_biotype: protein_coding
description:
  Arginine ABC transporter, permease protein (artM); Part of the ABC transporter complex ArtPIQM involved in arginine transport. Probably responsible for the translocation of the substrate across the membrane (By similarity).


ensembl_gene_id: HI_1178
symbol: artQ
gene_biotype: protein_coding
description:
  Arginine ABC transporter, permease protein (artQ); Part of the ABC transporter complex ArtPIQM involved in arginine transport. Probably responsible for the translocation of the substrate across the membrane (By similarity).


ensembl_gene_id: HI_1179
symbol: artI
gene_biotype: protein_coding
description:
  Arginine ABC transporter, periplasmic-binding protein (artI); Part of the ABC transporter complex ArtPIQM involved in arginine transport.


ensembl_gene_id: HI_1180
symbol: artP
gene_biotype: protein_coding
description:
  Arginine ABC transporter, ATP-binding protein (artP); Part of the ABC transporter complex ArtPIQM involved in arginine transport. Probably responsible for energy coupling to the transport system (By similarity).


ensembl_gene_id: HI_1181
symbol: gmhA
gene_biotype: protein_coding
description:
  Phosphoheptose isomerase (gmhA); Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate; Belongs to the SIS family. GmhA subfamily.


ensembl_gene_id: HI_1184
symbol: dppF
gene_biotype: protein_coding
description:
  Dipeptide ABC transporter, ATP-binding protein (dppF); Part of the binding-protein-dependent transport system for dipeptides. Probably responsible for energy coupling to the transport system (By similarity); Belongs to the ABC transporter superfamily.


ensembl_gene_id: HI_1185
symbol: dppD
gene_biotype: protein_coding
description:
  Dipeptide ABC transporter, ATP-binding protein (dppD); Part of the binding-protein-dependent transport system for dipeptides. Probably responsible for energy coupling to the transport system (By similarity); Belongs to the ABC transporter superfamily.


ensembl_gene_id: HI_1186
symbol: dppC
gene_biotype: protein_coding
description:
  Dipeptide ABC transporter, permease protein (dppC); Part of the binding-protein-dependent transport system for dipeptides; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily.


ensembl_gene_id: HI_1187
symbol: dppB
gene_biotype: protein_coding
description:
  Dipeptide ABC transporter, permease protein (dppB); Part of the binding-protein-dependent transport system for dipeptides; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. OppBC subfamily.


ensembl_gene_id: HI_1188
symbol: uvrD
gene_biotype: protein_coding
description:
  DNA helicase II (uvrD); May process damage occurring in non-replicating regions of DNA to produce recombinational intermediates for sister strand recombinational exchange.


ensembl_gene_id: HI_1189
symbol: queE
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.


ensembl_gene_id: HI_1190
symbol: queD
gene_biotype: protein_coding
description:
  6-pyruvoyl tetrahydrobiopterin synthase, putative; Catalyzes the conversion of 7,8-dihydroneopterin triphosphate (H2NTP) to 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) and acetaldehyde.


ensembl_gene_id: HI_1191
symbol: queC
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family.


ensembl_gene_id: HI_1193
symbol: ilvE
gene_biotype: protein_coding
description:
  Branched-chain-amino-acid transaminase (ilvE); Acts on leucine, isoleucine and valine; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.


ensembl_gene_id: HI_1194
symbol: gcvA
gene_biotype: protein_coding
description:
  Glycine cleavage system transcriptional activator (gcvA); Not known, the gcv operon regulated by the E.coli homolog does not exist in H.influenzae, so it probably acts as a transcriptional regulator on some other operon; Belongs to the LysR transcriptional regulatory family.


ensembl_gene_id: HI_1195
symbol: rlmM
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily.


ensembl_gene_id: HI_1196
symbol: sucC
gene_biotype: protein_coding
description:
  succinyl-CoA synthetase, beta subunit (sucC); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.


ensembl_gene_id: HI_1197
symbol: sucD
gene_biotype: protein_coding
description:
  succinyl-CoA synthetase, alpha subunit (sucD); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.


ensembl_gene_id: HI_1198
symbol: HI_1198
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to SP:P45847 PID:602960 GB:U00096 PID:1787521 percent identity: 71.30; identified by sequence similarity; putative; Belongs to the SUA5 family.


ensembl_gene_id: HI_1199
symbol: rluB
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Responsible for synthesis of pseudouridine from uracil-2605 in 23S ribosomal RNA; Belongs to the pseudouridine synthase RsuA family.


ensembl_gene_id: HI_1200
symbol: cysB
gene_biotype: protein_coding
description:
  Cys regulon transcriptional activator (cysB); This protein is a positive regulator of gene expression for the cysteine regulon. The inducer for CysB is N-acetylserine (By similarity).


ensembl_gene_id: HI_1201
symbol: prmB
gene_biotype: protein_coding
description:
  Adenine specific methylase, putative; Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue; Belongs to the protein N5-glutamine methyltransferase family. PrmB subfamily.


ensembl_gene_id: HI_1202
symbol: HI_1202
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:U00096 PID:1788671 percent identity: 53.09; identified by sequence similarity; putative; Belongs to the UPF0115 family.


ensembl_gene_id: HI_1203
symbol: pta
gene_biotype: protein_coding
description:
  Phosphate acetyltransferase (pta); Involved in acetate metabolism; In the N-terminal section; belongs to the CobB/CobQ family.


ensembl_gene_id: HI_1204
symbol: ackA
gene_biotype: protein_coding
description:
  Acetate kinase (ackA); Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family.


ensembl_gene_id: HI_1205
symbol: HI_1205
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:U00096 PID:1788632 GB:U00096 PID:1788632 percent identity: 45.45; identified by sequence similarity; putative.


ensembl_gene_id: HI_1206
symbol: cvpA
gene_biotype: protein_coding
description:
  Colicin V production protein (cvpA); Similar to GB:J01666 SP:P08550 PID:146367 PID:147415 GB:U00096 percent identity: 64.74; identified by sequence similarity; putative.


ensembl_gene_id: HI_1207
symbol: purF
gene_biotype: protein_coding
description:
  Amidophosphoribosyltransferase (purF); Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.


ensembl_gene_id: HI_1208
symbol: HI_1208
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:L42023 PID:1007092 PID:1221333 PID:1205451 PID:1574138 percent identity: 100.00; identified by sequence similarity; putative; Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.


ensembl_gene_id: HI_1211
symbol: lysS
gene_biotype: protein_coding
description:
  lysyl-tRNA synthetase (lysU); Similar to GB:U14003 GB:J03795 SP:P13030 SP:P14825 GB:M30630 percent identity: 70.38; identified by sequence similarity; putative; Belongs to the class-II aminoacyl-tRNA synthetase family.


ensembl_gene_id: HI_1213
symbol: dsbC
gene_biotype: protein_coding
description:
  Thiol:disulfide interchange protein (dsbC); Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbC is reoxidized by a yet uncharacterized protein. Also acts as a disulfide isomerase (By similarity).


ensembl_gene_id: HI_1214
symbol: recJ
gene_biotype: protein_coding
description:
  single-stranded-DNA-specific exonuclease (recJ); Single-stranded-DNA-specific exonuclease. Required for many types of recombinational events, although the stringency of the requirement for RecJ appears to vary with the type of recombinational event monitored and the other recombination gene products which are available (By similarity).


ensembl_gene_id: HI_1215
symbol: HI_1215
gene_biotype: protein_coding
description:
  Thiol:disulfide interchange protein (dsbA); Similar to PID:840949 SP:P50024 percent identity: 22.28; identified by sequence similarity; putative.


ensembl_gene_id: HI_1216
symbol: mtnN
gene_biotype: protein_coding
description:
  Pfs protein (pfs); Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily.


ensembl_gene_id: HI_1218
symbol: HI_1218
gene_biotype: protein_coding
description:
  L-lactate permease (lctP); May play a role in L-lactate transport; Belongs to the lactate permease family.


ensembl_gene_id: HI_1219
symbol: cmk1
gene_biotype: protein_coding
description:
  Cytidylate kinase 1 (cmkA); Similar to SP:P23863 PID:42839 GB:U00096 PID:1651431 PID:1651438 percent identity: 64.52; identified by sequence similarity; putative.


ensembl_gene_id: HI_1220
symbol: rpsA
gene_biotype: protein_coding
description:
  Ribosomal protein S1 (rpS1); Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity).


ensembl_gene_id: HI_1221
symbol: ihfB
gene_biotype: protein_coding
description:
  Integration host factor, beta-subunit (himD); This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family.


ensembl_gene_id: HI_1222
symbol: lapA
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Involved in the assembly of lipopolysaccharide (LPS). Belongs to the LapA family.


ensembl_gene_id: HI_1223
symbol: lapB
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane; Belongs to the LapB family.


ensembl_gene_id: HI_1224
symbol: pyrF
gene_biotype: protein_coding
description:
  Orotidine 5'-phosphate decarboxylase (pyrF); Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily.


ensembl_gene_id: HI_1225
symbol: HI_1225
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:J02768 SP:P08245 PID:147476 GB:U00096 PID:1787538 percent identity: 77.14; identified by sequence similarity; putative; Belongs to the SUI1 family.


ensembl_gene_id: HI_1225.1
symbol: HI_1225.1
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:U00096 PID:1788842 PID:1805556 percent identity: 48.03; identified by sequence similarity; putative; Belongs to the DnaA family. HdA subfamily.


ensembl_gene_id: HI_1227
symbol: uraA
gene_biotype: protein_coding
description:
  Uracil permease (uraA); Transport of uracil in the cell; Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily.


ensembl_gene_id: HI_1228
symbol: upp
gene_biotype: protein_coding
description:
  Uracil phosphoribosyltransferase (upp); Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate.


ensembl_gene_id: HI_1229
symbol: dnaX
gene_biotype: protein_coding
description:
  DNA polymerase III, subunits gamma and tau (dnaX); DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity; Belongs to the DnaX/STICHEL family.


ensembl_gene_id: HI_1230
symbol: apt
gene_biotype: protein_coding
description:
  Adenine phosphoribosyltransferase (apt); Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.


ensembl_gene_id: HI_1231
symbol: lpdA
gene_biotype: protein_coding
description:
  Dihydrolipoamide dehydrogenase (lpdA); Lipoamide dehydrogenase is a component of the alpha-ketoacid dehydrogenase complexes; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.


ensembl_gene_id: HI_1232
symbol: aceF
gene_biotype: protein_coding
description:
  Dihydrolipoamide acetyltransferase (aceF); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).


ensembl_gene_id: HI_1233
symbol: aceE
gene_biotype: protein_coding
description:
  Pyruvate dehydrogenase, E1 component (aceE); Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).


ensembl_gene_id: HI_1234
symbol: mgsA
gene_biotype: protein_coding
description:
  Methylglyoxal synthase (mgsA); Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.


ensembl_gene_id: HI_1236
symbol: HI_1236
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to PID:868023 GB:U00096 PID:1787900 percent identity: 26.52; identified by sequence similarity; putative.


ensembl_gene_id: HI_1238
symbol: dnaJ
gene_biotype: protein_coding
description:
  Heat shock protein (dnaJ); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ [...]


ensembl_gene_id: HI_1239
symbol: proA
gene_biotype: protein_coding
description:
  Gamma-glutamyl phosphate reductase (proA); Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family.


ensembl_gene_id: HI_1240
symbol: HI_1240
gene_biotype: protein_coding
description:
  Conserved hypothetical transmembrane protein; Similar to GB:L10328 SP:P31432 PID:290496 GB:U00096 PID:1790078 percent identity: 63.55; identified by sequence similarity; putative.


ensembl_gene_id: HI_1242
symbol: bcr
gene_biotype: protein_coding
description:
  Bicyclomycin resistance protein (bcr); Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance. Probable membrane translocase (By similarity). Belongs to the major facilitator superfamily. Bcr/CmlA family.


ensembl_gene_id: HI_1243
symbol: rsuA
gene_biotype: protein_coding
description:
  16s pseudouridylate 516 synthase (rsuA); Responsible for synthesis of pseudouridine from uracil-516 in 16S ribosomal RNA; Belongs to the pseudouridine synthase RsuA family.


ensembl_gene_id: HI_1245
symbol: maeB
gene_biotype: protein_coding
description:
  Malate oxidoreductase, putative; Similar to GB:U00096 PID:1788806 PID:1799885 PID:1799887 percent identity: 68.69; identified by sequence similarity; putative; In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.


ensembl_gene_id: HI_1247
symbol: uvrB
gene_biotype: protein_coding
description:
  Excinuclease ABC, subunit B (uvrB); The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dis [...]


ensembl_gene_id: HI_1248
symbol: HI_1248
gene_biotype: protein_coding
description:
  Predicted coding region HI1248; Efflux system for nickel and cobalt; Belongs to the NiCoT transporter (TC 2.A.52) family.


ensembl_gene_id: HI_1251
symbol: HI_1251
gene_biotype: protein_coding
description:
  Virulence associated protein A (vapA); Similar to PID:1002991 PID:563265 SP:Q46560 percent identity: 38.10; identified by sequence similarity; putative; Belongs to the VapA/VapI family.


ensembl_gene_id: HI_1252
symbol: ettA
gene_biotype: protein_coding
description:
  ABC transporter, ATP-binding protein; A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase; Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.


ensembl_gene_id: HI_1253
symbol: HI_1253
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to PID:968932 GB:U00096 PID:1787464 percent identity: 31.73; identified by sequence similarity; putative.


ensembl_gene_id: HI_1254
symbol: tmcA
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).


ensembl_gene_id: HI_1258
symbol: mfd
gene_biotype: protein_coding
description:
  Transcription-repair coupling factor (mfd); Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the N-terminal section; belongs to the UvrB family.


ensembl_gene_id: HI_1259
symbol: HI_1259
gene_biotype: protein_coding
description:
  Periplasmic serine protease; Similar to SP:P39099 PID:558912 PID:606173 PID:984379 GB:U00096 percent identity: 59.30; identified by sequence similarity; putative.


ensembl_gene_id: HI_1260
symbol: accD
gene_biotype: protein_coding
description:
  acetyl-CoA carboxylase carboxyl transferase subunit beta (accD); Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family.


ensembl_gene_id: HI_1261
symbol: folC
gene_biotype: protein_coding
description:
  Folylpolyglutamate synthase/dihydrofolate synthase (folC); Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10- formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives.


ensembl_gene_id: HI_1263
symbol: metXA
gene_biotype: protein_coding
description:
  Homoserine acetyltransferase (met2); Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. Utilizes a ping-pong kinetic mechanism in which the acetyl group of acetyl-CoA is initially transferred to the enzyme to form an acetyl- enzyme intermediate before subsequent transfer to homoserine to form the final product, O-acetylhomoserine.


ensembl_gene_id: HI_1264
symbol: gyrA
gene_biotype: protein_coding
description:
  DNA gyrase, subunit A (gyrA); A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.


ensembl_gene_id: HI_1265
symbol: HI_1265
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:U00096 SP:P75838 PID:1787133 percent identity: 66.90; identified by sequence similarity; putative.


ensembl_gene_id: HI_1272
symbol: HI_1272
gene_biotype: protein_coding
description:
  ABC transporter, ATP-binding protein; Similar to GB:AE000511 SP:O05732 PID:2072456 PID:2314024 percent identity: 34.43; identified by sequence similarity; putative; Belongs to the ABC transporter superfamily.


ensembl_gene_id: HI_1273
symbol: HI_1273
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to PID:1816658 percent identity: 37.25; identified by sequence similarity; putative.


ensembl_gene_id: HI_1274
symbol: gloB
gene_biotype: protein_coding
description:
  Hydroxyacylglutathione hydrolase, putative; Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl- glutathione to form glutathione and D-lactic acid.


ensembl_gene_id: HI_1275
symbol: tehB
gene_biotype: protein_coding
description:
  Tellurite resistance protein (tehB); Probable S-adenosyl-L-methionine-dependent methyltransferase. Plays a role in both resistance to oxidative damage and heme uptake/utilization. Also protects H.influenzae from tellurite exposure in vitro; however, since H.influenzae grows only in humans, it is unlikely to encounter tellurite in its natural environment, and it is thus probable that tellurite resistance does not represent a biologically relevant role of TehB (By similarity); Belongs to the TehB family.


ensembl_gene_id: HI_1276
symbol: metG
gene_biotype: protein_coding
description:
  methionyl-tRNA synthetase (metG); Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.


ensembl_gene_id: HI_1277
symbol: mrp
gene_biotype: protein_coding
description:
  ATP-binding protein (mrp); Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family.


ensembl_gene_id: HI_1278
symbol: HI_1278
gene_biotype: protein_coding
description:
  NAD(P)H-flavin oxidoreductase; Similar to GB:D17743 SP:P46072 PID:517169 percent identity: 33.33; identified by sequence similarity; putative.


ensembl_gene_id: HI_1279
symbol: neuA
gene_biotype: protein_coding
description:
  Acylneuraminate cytidylyltransferase (neuA); Similar to GB:M95053 GB:X78068 GB:U04328 PID:460146 PID:520734 percent identity: 47.06; identified by sequence similarity; putative; Belongs to the CMP-NeuNAc synthase family.


ensembl_gene_id: HI_1280
symbol: HI_1280
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:M29945 PID:1197032 percent identity: 50.43; identified by sequence similarity; putative.


ensembl_gene_id: HI_1282
symbol: rimP
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Required for maturation of 30S ribosomal subunits. Belongs to the RimP family.


ensembl_gene_id: HI_1283
symbol: nusA
gene_biotype: protein_coding
description:
  N utilization substance protein A (nusA); Participates in both transcription termination and antitermination.


ensembl_gene_id: HI_1284
symbol: infB
gene_biotype: protein_coding
description:
  Translation initiation factor 2 (infB); One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity); Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.


ensembl_gene_id: HI_1285
symbol: HI_1285
gene_biotype: protein_coding
description:
  Type I restriction enzyme (hsdR); Subunit R is required for both nuclease and ATPase activities, but not for modification.


ensembl_gene_id: HI_1287
symbol: HI_1287
gene_biotype: protein_coding
description:
  Type I modification enzyme (hsdM); Methylation of specific adenine residues; required for both restriction and modification activities.


ensembl_gene_id: HI_1288
symbol: rbfA
gene_biotype: protein_coding
description:
  Ribosome binding factor A (rbfA); One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.


ensembl_gene_id: HI_1289
symbol: truB
gene_biotype: protein_coding
description:
  tRNA pseudouridine 55 synthase (truB); Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.


ensembl_gene_id: HI_1290
symbol: tyrA
gene_biotype: protein_coding
description:
  Chorismate mutase / prephenate dehydrogenase (tyrA); Similar to SP:Q02287 GB:M74135 GB:X60420 PID:415010 PID:43345 percent identity: 58.86; identified by sequence similarity; putative.


ensembl_gene_id: HI_1291
symbol: queF
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).


ensembl_gene_id: HI_1293
symbol: HI_1293
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to PID:882706 GB:U00096 SP:Q46926 PID:1789176 percent identity: 36.89; identified by sequence similarity; putative; Belongs to the SufE family.


ensembl_gene_id: HI_1295
symbol: csd
gene_biotype: protein_coding
description:
  nifS protein, putative; Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.


ensembl_gene_id: HI_1296
symbol: HI_1296
gene_biotype: protein_coding
description:
  Nuclease, putative; Similar to SP:P29769 percent identity: 46.62; identified by sequence similarity; putative; Belongs to the thermonuclease family.


ensembl_gene_id: HI_1297
symbol: HI_1297
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to SP:P33372 PID:405872 GB:U00096 PID:1788463 percent identity: 41.18; identified by sequence similarity; putative.


ensembl_gene_id: HI_1298
symbol: HI_1298
gene_biotype: protein_coding
description:
  Conserved hypothetical transmembrane protein; Similar to SP:P33373 PID:405873 GB:U00096 PID:1788464 percent identity: 43.52; identified by sequence similarity; putative.


ensembl_gene_id: HI_1300
symbol: uup
gene_biotype: protein_coding
description:
  ABC transporter, ATP-binding protein; Probably plays a role in ribosome assembly or function. May be involved in resolution of branched DNA intermediates that result from template switching in postreplication gaps. Binds DNA and has ATPase activity; Belongs to the ABC transporter superfamily. ABCF family. Uup subfamily.


ensembl_gene_id: HI_1301
symbol: can
gene_biotype: protein_coding
description:
  Carbonic anhydrase, putative; Similar to PID:1513236 percent identity: 57.55; identified by sequence similarity; putative; Belongs to the beta-class carbonic anhydrase family.


ensembl_gene_id: HI_1302
symbol: asnS
gene_biotype: protein_coding
description:
  asparaginyl-tRNA synthetase (asnS); Similar to GB:M33145 SP:P17242 GB:X68192 PID:147935 PID:41000 percent identity: 80.65; identified by sequence similarity; putative.


ensembl_gene_id: HI_1303
symbol: ribH
gene_biotype: protein_coding
description:
  Riboflavin synthase, beta chain (ribH); Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family.


ensembl_gene_id: HI_1304
symbol: nusB
gene_biotype: protein_coding
description:
  N utilization substance protein B (nusB); Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.


ensembl_gene_id: HI_1305
symbol: thiL
gene_biotype: protein_coding
description:
  Thiamin-monophosphate kinase (thiL); Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family.


ensembl_gene_id: HI_1306
symbol: pgpA
gene_biotype: protein_coding
description:
  Phosphatidylglycerophosphatase A (pgpA); Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG).


ensembl_gene_id: HI_1307
symbol: HI_1307
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:U00096 SP:P75693 PID:1657525 PID:1786522 percent identity: 26.87; identified by sequence similarity; putative.


ensembl_gene_id: HI_1308
symbol: dapB
gene_biotype: protein_coding
description:
  Dihydrodipicolinate reductase (dapB); Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.


ensembl_gene_id: HI_1309
symbol: HI_1309
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to SP:P37910 GB:U00096 PID:1788568 percent identity: 54.41; identified by sequence similarity; putative.


ensembl_gene_id: HI_1311
symbol: pheS
gene_biotype: protein_coding
description:
  phenylalanyl-tRNA synthetase, alpha subunit (pheS); Similar to GB:V00291 SP:P08312 PID:146345 PID:43070 GB:U00096 percent identity: 75.00; identified by sequence similarity; putative; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.


ensembl_gene_id: HI_1312
symbol: pheT
gene_biotype: protein_coding
description:
  phenylalanyl-tRNA synthetase, beta subunit (pheT); Similar to GB:K02844 SP:P07395 PID:146346 PID:43071 GB:U00096 percent identity: 65.28; identified by sequence similarity; putative; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.


ensembl_gene_id: HI_1313
symbol: ihfA
gene_biotype: protein_coding
description:
  Integration host factor, alpha-subunit (himA); This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family.


ensembl_gene_id: HI_1314
symbol: HI_1314
gene_biotype: protein_coding
description:
  Lipoprotein (nlpC); Similar to GB:M14031 SP:P23898 PID:145446 GB:U00096 PID:1742788 percent identity: 53.85; identified by sequence similarity; putative.


ensembl_gene_id: HI_1317
symbol: HI_1317
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:U00096 SP:P39173 PID:1736408 PID:1742898 PID:1788080 percent identity: 39.01; identified by sequence similarity; putative.


ensembl_gene_id: HI_1318
symbol: infC
gene_biotype: protein_coding
description:
  Translation initiation factor 3 (infC); IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.


ensembl_gene_id: HI_1319
symbol: rpmI
gene_biotype: protein_coding
description:
  Ribosomal protein L35 (rpL35); Similar to SP:P07085 GB:U00096 PID:1742796 PID:1742809 PID:1788010 percent identity: 78.46; identified by sequence similarity; putative; Belongs to the bacterial ribosomal protein bL35 family.


ensembl_gene_id: HI_1320
symbol: rplT
gene_biotype: protein_coding
description:
  Ribosomal protein L20 (rpL20); Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity).


ensembl_gene_id: HI_1321
symbol: recB
gene_biotype: protein_coding
description:
  Exodeoxyribonuclease V, beta chain (recB); A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination a [...]


ensembl_gene_id: HI_1322
symbol: recD
gene_biotype: protein_coding
description:
  Exodeoxyribonuclease V, alpha chain (recD); A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination  [...]


ensembl_gene_id: HI_1323
symbol: matP
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain.


ensembl_gene_id: HI_1324
symbol: HI_1324
gene_biotype: protein_coding
description:
  Lon protease, putative; Similar to GB:D00863 SP:P36772 PID:402504 percent identity: 24.16; identified by sequence similarity; putative.


ensembl_gene_id: HI_1325
symbol: fabA
gene_biotype: protein_coding
description:
  3-hydroxydecanoyl-(acyl carrier-protein) dehydratase (fabA); Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E- (2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length (By similarity).


ensembl_gene_id: HI_1328
symbol: rpsO1
gene_biotype: protein_coding
description:
  Ribosomal protein S15 (rpS15); One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.


ensembl_gene_id: HI_1328.1
symbol: HI_1328.1
gene_biotype: protein_coding
description:
  Predicted coding region HI1328.1; Brute Force ORF; identified by GeneMark; putative; To insertion element IS1016 transposase.


ensembl_gene_id: HI_1329
symbol: HI_1329
gene_biotype: protein_coding
description:
  IS1016-V6 protein (IS1016-V6); Similar to GB:X59756 percent identity: 54.71; identified by sequence similarity; putative.


ensembl_gene_id: HI_1330
symbol: dacB
gene_biotype: protein_coding
description:
  D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase (dacB); Not involved in transpeptidation but exclusively catalyzes a DD-carboxypeptidase and DD-endopeptidase reaction; Belongs to the peptidase S13 family.


ensembl_gene_id: HI_1331
symbol: greA
gene_biotype: protein_coding
description:
  Transcription elongation factor (greA); Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity).


ensembl_gene_id: HI_1333
symbol: HI_1333
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to SP:P42550 PID:606118 GB:U00096 PID:1789570 percent identity: 75.00; identified by sequence similarity; putative.


ensembl_gene_id: HI_1334
symbol: rlmE
gene_biotype: protein_coding
description:
  Cell division protein (ftsJ); Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.


ensembl_gene_id: HI_1335
symbol: ftsH
gene_biotype: protein_coding
description:
  Cell division protein (ftsH); Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; In the central section; belongs to the AAA ATPase family.


ensembl_gene_id: HI_1336
symbol: folP-A
gene_biotype: protein_coding
description:
  Dihydropteroate synthase (folP-1); Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives.


ensembl_gene_id: HI_1337
symbol: glmM1
gene_biotype: protein_coding
description:
  mrsA protein (mrsA); Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family.


ensembl_gene_id: HI_1338
symbol: sixA-A
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:U00096 PID:1788681 percent identity: 40.26; identified by sequence similarity; putative; Belongs to the SixA phosphatase family.


ensembl_gene_id: HI_1339
symbol: HI_1339
gene_biotype: protein_coding
description:
  Predicted coding region HI1339; Hypothetical protein; identified by GeneMark; putative; Belongs to the LEA type 1 family.


ensembl_gene_id: HI_1340
symbol: HI_1340
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to PID:882689 GB:U00096 SP:Q46920 PID:1789158 percent identity: 58.08; identified by sequence similarity; putative; Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.


ensembl_gene_id: HI_1342
symbol: uup-B
gene_biotype: protein_coding
description:
  ABC transporter, ATP-binding protein; Might play a role in ribosome assembly or function; this is missing the first ABC transporter domain compared to paralogs.


ensembl_gene_id: HI_1343
symbol: HI_1343
gene_biotype: protein_coding
description:
  Predicted coding region HI1343; Hypothetical protein; identified by GeneMark; putative; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.


ensembl_gene_id: HI_1345
symbol: potC
gene_biotype: protein_coding
description:
  Spermidine/putrescine ABC transporter, permease protein (potC); Required for the activity of the bacterial periplasmic transport system of putrescine and spermidine; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.


ensembl_gene_id: HI_1346
symbol: potB
gene_biotype: protein_coding
description:
  Spermidine/putrescine ABC transporter, permease protein (potB); Required for the activity of the bacterial periplasmic transport system of putrescine and spermidine; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.


ensembl_gene_id: HI_1347
symbol: potA
gene_biotype: protein_coding
description:
  Spermidine/putrescine ABC transporter, ATP-binding protein (potA); Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.


ensembl_gene_id: HI_1348
symbol: pepT
gene_biotype: protein_coding
description:
  Peptidase T (pepT); Cleaves the N-terminal amino acid of tripeptides. Belongs to the peptidase M20B family.


ensembl_gene_id: HI_1349
symbol: HI_1349
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to PID:1652428 percent identity: 31.37; identified by sequence similarity; putative; Belongs to the Dps family.


ensembl_gene_id: HI_1350
symbol: cdd
gene_biotype: protein_coding
description:
  Cytidine deaminase (cdd); This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.


ensembl_gene_id: HI_1351
symbol: cmoB
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L- methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5- carboxymethoxyuridine (cmo5U) at position 34 in tRNAs.


ensembl_gene_id: HI_1352
symbol: putP
gene_biotype: protein_coding
description:
  Sodium/proline symporter (proline permease) (putP); Catalyzes the sodium-dependent uptake of extracellular L- proline; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.


ensembl_gene_id: HI_1353
symbol: rng
gene_biotype: protein_coding
description:
  Cytoplasmic axial filament protein (cafA); Involved in the processing of the 5'-end of 16S rRNA. Could be involved in chromosome segregation and cell division. It may be one of the components of the cytoplasmic axial filaments bundles or merely regulate the formation of this structure (By similarity).


ensembl_gene_id: HI_1354
symbol: glnS
gene_biotype: protein_coding
description:
  glutaminyl-tRNA synthetase (glnS); Similar to GB:V01575 SP:P00962 GB:J01617 GB:M10187 PID:146168 percent identity: 76.28; identified by sequence similarity; putative.


ensembl_gene_id: HI_1355
symbol: HI_1355
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:U00096 PID:1787429 percent identity: 45.70; identified by sequence similarity; putative; Belongs to the UPF0260 family.


ensembl_gene_id: HI_1356
symbol: malQ
gene_biotype: protein_coding
description:
  4-alpha-glucanotransferase (malQ); Similar to GB:M32793 SP:P15977 PID:146715 PID:606351 GB:U00096 percent identity: 41.59; identified by sequence similarity; putative; Belongs to the disproportionating enzyme family.


ensembl_gene_id: HI_1357
symbol: glgB
gene_biotype: protein_coding
description:
  1,4-alpha-glucan branching enzyme (glgB); Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position; Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.


ensembl_gene_id: HI_1358
symbol: glgX
gene_biotype: protein_coding
description:
  Glycogen operon protein (glgX); Similar to GB:J01616 SP:P15067 PID:146135 PID:606366 GB:U00096 percent identity: 52.77; identified by sequence similarity; putative; Belongs to the glycosyl hydrolase 13 family.


ensembl_gene_id: HI_1359
symbol: glgC
gene_biotype: protein_coding
description:
  Glucose-1-phosphate adenylyltransferase (glgC); Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc; Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.


ensembl_gene_id: HI_1361
symbol: glgP
gene_biotype: protein_coding
description:
  Glycogen phosphorylase (glgP); Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity).


ensembl_gene_id: HI_1362
symbol: pntA
gene_biotype: protein_coding
description:
  NAD(P) transhydrogenase, subunit alpha (pntA); The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the AlaDH/PNT family.


ensembl_gene_id: HI_1363
symbol: pntB
gene_biotype: protein_coding
description:
  NAD(P) transhydrogenase, subunit beta (pntB); The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family.


ensembl_gene_id: HI_1364
symbol: HI_1364
gene_biotype: protein_coding
description:
  Transcriptional regulator, putative; Similar to SP:P37641 PID:466658 GB:U00096 PID:1789938 percent identity: 36.04; identified by sequence similarity; putative; Belongs to the LysR transcriptional regulatory family.


ensembl_gene_id: HI_1365
symbol: topA
gene_biotype: protein_coding
description:
  DNA topoisomerase I (topA); Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing D [...]


ensembl_gene_id: HI_1366
symbol: azoR
gene_biotype: protein_coding
description:
  Acyl carrier protein phosphodiesterase (acpD); Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity; Belongs to the azoreductase type 1 family.


ensembl_gene_id: HI_1367
symbol: thrS
gene_biotype: protein_coding
description:
  threonyl-tRNA synthetase (thrS); Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).


ensembl_gene_id: HI_1368
symbol: pqqL
gene_biotype: protein_coding
description:
  Zinc protease, putative; Similar to SP:P31828 GB:X71917 PID:535004 GB:U00096 PID:1742451 percent identity: 28.76; identified by sequence similarity; putative.


ensembl_gene_id: HI_1369
symbol: HI_1369
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to SP:P31827 GB:X71917 PID:311346 GB:U00096 PID:1787771 percent identity: 25.46; identified by sequence similarity; putative; To E.coli YddB.


ensembl_gene_id: HI_1370
symbol: HI_1370
gene_biotype: protein_coding
description:
  Molybdenum-pterin binding protein (mopI); Binds one mole of molybdenum per mole of protein and contains a pterin.


ensembl_gene_id: HI_1371
symbol: tusE
gene_biotype: protein_coding
description:
  Desulfoviridin gamma subunit, putative; Could be part of a sulfur-relay system; Belongs to the DsrC/TusE family.


ensembl_gene_id: HI_1371.1
symbol: ttcA
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.


ensembl_gene_id: HI_1372
symbol: mukF
gene_biotype: protein_coding
description:
  Killing protein (kicB); Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity.


ensembl_gene_id: HI_1373
symbol: mukE
gene_biotype: protein_coding
description:
  Killing protein suppressor (kicA); Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF.


ensembl_gene_id: HI_1374
symbol: mukB
gene_biotype: protein_coding
description:
  Cell division protein (mukB); Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division; Belongs to the SMC family. MukB subfamily.


ensembl_gene_id: HI_1377
symbol: sbcB
gene_biotype: protein_coding
description:
  Exodeoxyribonuclease I (sbcB); Degrades single-stranded DNA (ssDNA) in a highly processive manner. Also functions as a DNA deoxyribophosphodiesterase that releases deoxyribose-phosphate moieties following the cleavage of DNA at an apurinic/apyrimidinic (AP) site by either an AP endonuclease or AP lyase.


ensembl_gene_id: HI_1378
symbol: phoR
gene_biotype: protein_coding
description:
  Phosphate regulon sensor protein (phoR); Member of the two-component regulatory system PhoR/PhoB involved in the phosphate regulon genes expression. PhoR may function as a membrane-associated protein kinase that phosphorylates PhoB in response to environmental signals (By similarity).


ensembl_gene_id: HI_1379
symbol: phoB
gene_biotype: protein_coding
description:
  Phosphate regulon transcriptional regulatory protein (phoB); This protein is a positive regulator for the phosphate regulon. Transcription of this operon is positively regulated by PhoB and PhoR when phosphate is limited (By similarity).


ensembl_gene_id: HI_1381
symbol: pstA
gene_biotype: protein_coding
description:
  Phosphate ABC transporter, permease protein (pstA); Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.


ensembl_gene_id: HI_1382
symbol: pstC
gene_biotype: protein_coding
description:
  Phosphate ABC transporter, permease protein (pstC); Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.


ensembl_gene_id: HI_1383
symbol: pstS
gene_biotype: protein_coding
description:
  Phosphate ABC transporter, periplasmic-binding protein (pstS); Part of the ABC transporter complex PstSACB involved in phosphate import.


ensembl_gene_id: HI_1385
symbol: ftnB
gene_biotype: protein_coding
description:
  Ferritin (rsgA); Similar to SP:P23887 GB:X53513 PID:42898 GB:U00096 PID:1736567 percent identity: 57.32; identified by sequence similarity; putative.


ensembl_gene_id: HI_1387
symbol: trpE
gene_biotype: protein_coding
description:
  Anthranilate synthase component I (trpE); Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high c [...]


ensembl_gene_id: HI_1388
symbol: trpG
gene_biotype: protein_coding
description:
  Anthranilate synthase component II (trpG); Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high  [...]


ensembl_gene_id: HI_1389
symbol: trpD
gene_biotype: protein_coding
description:
  Anthanilate phosphoribosyltransferase (trpD); Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA).


ensembl_gene_id: HI_1389.1
symbol: trpC
gene_biotype: protein_coding
description:
  Indole-3-glycerol phosphate synthase / phosphoribosylanthranilate isomerase (trpC); Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the TrpF domain; the second reaction is catalyzed by the synthase, coded by the TrpC domain (By similarity).


ensembl_gene_id: HI_1390
symbol: HI_1390
gene_biotype: protein_coding
description:
  Hydrogenase formation protein (hypG); Similar to SP:P37185 GB:U09177 PID:544489 PID:882519 GB:U00096 percent identity: 63.16; identified by sequence similarity; putative.


ensembl_gene_id: HI_1391
symbol: valS
gene_biotype: protein_coding
description:
  valyl-tRNA synthetase (valS); Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.


ensembl_gene_id: HI_1392
symbol: hindIIIM
gene_biotype: protein_coding
description:
  Modification methylase (hindIIIM); This methylase recognizes the double-stranded sequence AAGCTT, causes specific methylation on A-1 on both strands, and protects the DNA from cleavage by the HindIII endonuclease; Belongs to the N(4)/N(6)-methyltransferase family.


ensembl_gene_id: HI_1393
symbol: hindIIIR
gene_biotype: protein_coding
description:
  Type II restriction endonuclease (hindIIIR); Recognizes the double-stranded sequence AAGCTT and cleaves after A-1.


ensembl_gene_id: HI_1394
symbol: HI_1394
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to PID:887850 GB:U00096 SP:Q46828 PID:1789267 percent identity: 68.32; identified by sequence similarity; putative; Belongs to the UPF0267 family.


ensembl_gene_id: HI_1397
symbol: holC
gene_biotype: protein_coding
description:
  DNA polymerase III, chi subunit (holC); DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity).


ensembl_gene_id: HI_1398
symbol: fumC
gene_biotype: protein_coding
description:
  Fumarate hydratase, class II (fumC); Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.


ensembl_gene_id: HI_1400
symbol: HI_1400
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Efficiently catalyzes the hydrolysis of the 3'-phosphate from 3',5'-bis-phosphonucleotides as well as the successive hydrolysis of 5'-phosphomononucleotides from the 5'-end of short pieces of RNA and DNA, with no specificity toward the identity of the nucleotide base. Is more efficient at hydrolyzing RNA oligonucleotides than DNA oligonucleotides. This enzyme can also hydrolyze annealed DNA duplexes, albeit at a catalytic efficiency lower than that of the corresponding single-stranded oligonucleotides.


ensembl_gene_id: HI_1401
symbol: pyrD
gene_biotype: protein_coding
description:
  Dihydroorotate dehydrogenase (pyrD); Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.


ensembl_gene_id: HI_1407
symbol: HI_1407
gene_biotype: protein_coding
description:
  traN-related protein; Similar to GB:L10330 PID:437700 percent identity: 40.17; identified by sequence similarity; putative; To E.coli plasmid IncP-alpha RP4 protein TraN.


ensembl_gene_id: HI_1411
symbol: HI_1411
gene_biotype: protein_coding
description:
  Terminase, small subunit; Similar to SP:Q38627 PID:522116 percent identity: 32.31; identified by sequence similarity; putative.


ensembl_gene_id: HI_1412
symbol: HI_1412
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to SP:P21417 PID:1196685 percent identity: 31.79; identified by sequence similarity; putative.


ensembl_gene_id: HI_1415
symbol: HI_1415
gene_biotype: protein_coding
description:
  Predicted coding region HI1415; Hypothetical protein; identified by GeneMark; putative; Belongs to the glycosyl hydrolase 19 family.


ensembl_gene_id: HI_1424
symbol: HI_1424
gene_biotype: protein_coding
description:
  Integrase/recombinase, putative; Similar to SP:P10487 GB:D90039 SP:P16470 GB:X05022 GB:X12577 percent identity: 31.10; identified by sequence similarity; putative; Belongs to the 'phage' integrase family.


ensembl_gene_id: HI_1425
symbol: fnr
gene_biotype: protein_coding
description:
  Fumarate (and nitrate) reduction regulatory protein (fnr); It is involved in the activation of genes necessary for anaerobic respiration.


ensembl_gene_id: HI_1426
symbol: uspE
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Required for resistance to DNA-damaging agents. Belongs to the universal stress protein A family.


ensembl_gene_id: HI_1428
symbol: purN
gene_biotype: protein_coding
description:
  Phosphoribosylglycinamide formyltransferase (purN); Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.


ensembl_gene_id: HI_1429
symbol: purM
gene_biotype: protein_coding
description:
  Phosphoribosylaminoimidazole synthetase (purM); Similar to GB:M13747 SP:P08178 PID:147425 GB:U00096 PID:1788845 percent identity: 76.30; identified by sequence similarity; putative.


ensembl_gene_id: HI_1430
symbol: HI_1430
gene_biotype: protein_coding
description:
  Short chain dehydrogenase/reductase; Similar to GB:U00096 PID:1787820 percent identity: 58.13; identified by sequence similarity; putative; Belongs to the short-chain dehydrogenases/reductases (SDR) family.


ensembl_gene_id: HI_1431
symbol: trpB
gene_biotype: protein_coding
description:
  Tryptophan synthase beta subunit (trpB); The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.


ensembl_gene_id: HI_1432
symbol: trpA
gene_biotype: protein_coding
description:
  Tryptophan synthase alpha subunit (trpA); The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.


ensembl_gene_id: HI_1433
symbol: usg
gene_biotype: protein_coding
description:
  Usg-1 protein (usg1); Similar to SP:P08390 GB:X02743 PID:147125 PID:41717 GB:U00096 percent identity: 32.71; identified by sequence similarity; putative; Belongs to the aspartate-semialdehyde dehydrogenase family.


ensembl_gene_id: HI_1434
symbol: ybaK
gene_biotype: protein_coding
description:
  Transcriptional regulator, putative; Functions in trans to edit the amino acid from incorrectly charged Cys-tRNA(Pro) via a Cys-tRNA(Pro) deacylase activity. Probably compensates for the lack of Cys-tRNA(Pro) editing by ProRS. Is also able to deacylate Cys-tRNA(Cys), and displays weak deacylase activity in vitro against Gly-tRNA(Gly), as well as, at higher concentrations, some other correctly charged tRNAs. Does not cleave Pro-tRNA(Pro). Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily.


ensembl_gene_id: HI_1434.1
symbol: cspD
gene_biotype: protein_coding
description:
  Cold shock-like protein (cspD); Similar to SP:P24245 GB:U00096 PID:1651400 PID:1787107 percent identity: 68.66; identified by sequence similarity; putative.


ensembl_gene_id: HI_1434.2
symbol: HI_1434.2
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:U00096 PID:1788113 percent identity: 65.12; identified by sequence similarity; putative; Belongs to the UPF0181 family.


ensembl_gene_id: HI_1435
symbol: truC
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Responsible for synthesis of pseudouridine from uracil-65 in transfer RNAs; Belongs to the pseudouridine synthase RluA family.


ensembl_gene_id: HI_1436
symbol: HI_1436
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to PID:882688 GB:U00096 PID:882687 percent identity: 33.65; identified by sequence similarity; putative; To the N-terminal of E.carotovora exoenzyme regulation regulon ORF1. The C-terminal part is colinear with YqcB.


ensembl_gene_id: HI_1437
symbol: xseB
gene_biotype: protein_coding
description:
  Exodeoxyribonuclease, small subunit (xseB); Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides. It can also degrade 3' or 5' ss regions extending from the termini of duplex DNA molecules and displaced ss regions (By similarity); Belongs to the XseB family.


ensembl_gene_id: HI_1438
symbol: ispA
gene_biotype: protein_coding
description:
  Geranyltranstransferase (ispA); Similar to GB:D00694 SP:P22939 PID:216584 GB:U00096 PID:1773105 percent identity: 53.56; identified by sequence similarity; putative.


ensembl_gene_id: HI_1439
symbol: dxs
gene_biotype: protein_coding
description:
  1-deoxyxylulose-5-phosphate synthase (dxs) {Escherichia coli); Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily.


ensembl_gene_id: HI_1440
symbol: sspB
gene_biotype: protein_coding
description:
  Stringent starvation protein B (sspB); Enhances recognition of ssrA-tagged proteins by the ClpX-ClpP protease; the ssrA degradation tag (AANDENYALAA) is added trans- translationally to proteins that are stalled on the ribosome, freeing the ribosome and targeting stalled peptides for degradation. SspB activates the ATPase activity of ClpX. Seems to act in concert with SspA in the regulation of several proteins during exponential and stationary-phase growth (By similarity).


ensembl_gene_id: HI_1441
symbol: sspA
gene_biotype: protein_coding
description:
  Stringent starvation protein A (sspA); Forms an equimolar complex with the RNA polymerase holoenzyme (RNAP) but not with the core enzyme.


ensembl_gene_id: HI_1442
symbol: rpsI
gene_biotype: protein_coding
description:
  Ribosomal protein S9 (rpS9); Similar to GB:S75161 SP:P31782 PID:241867 percent identity: 94.62; identified by sequence similarity; putative; Belongs to the universal ribosomal protein uS9 family.


ensembl_gene_id: HI_1443
symbol: rplM
gene_biotype: protein_coding
description:
  Ribosomal protein L13 (rpL13); This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.


ensembl_gene_id: HI_1444
symbol: metF
gene_biotype: protein_coding
description:
  5,10 methylenetetrahydrofolate reductase (metF); Similar to GB:L19201 SP:P00394 GB:V01502 PID:305044 PID:42000 percent identity: 73.10; identified by sequence similarity; putative; Belongs to the methylenetetrahydrofolate reductase family.


ensembl_gene_id: HI_1445
symbol: bioD1
gene_biotype: protein_coding
description:
  Dethiobiotin synthase (bioD-1); Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring.


ensembl_gene_id: HI_1446
symbol: HI_1446
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:U00096 PID:1787427 percent identity: 41.67; identified by sequence similarity; putative.


ensembl_gene_id: HI_1447
symbol: folE
gene_biotype: protein_coding
description:
  GTP cyclohydrolase I (folE); Similar to GB:U00007 SP:P27511 GB:X63910 PID:312964 PID:405902 percent identity: 63.93; identified by sequence similarity; putative.


ensembl_gene_id: HI_1448
symbol: moeA
gene_biotype: protein_coding
description:
  Molybdopterin biosynthesis protein (moeA); Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP; Belongs to the MoeA family.


ensembl_gene_id: HI_1449
symbol: moeB
gene_biotype: protein_coding
description:
  Molybdopterin biosynthesis protein (moeB); Catalyzes the adenylation by ATP of the carboxyl group of the C-terminal glycine of sulfur carrier protein MoaD; Belongs to the HesA/MoeB/ThiF family.


ensembl_gene_id: HI_1450
symbol: HI_1450
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:U00096 PID:1787501 percent identity: 48.65; identified by sequence similarity; putative; Belongs to the UPF0263 family.


ensembl_gene_id: HI_1453
symbol: HI_1453
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:AL009126 percent identity: 30.84; identified by sequence similarity; putative; Belongs to the thioredoxin family.


ensembl_gene_id: HI_1454
symbol: HI_1454
gene_biotype: protein_coding
description:
  Cytochrome C-type biogenesis protein; Could be involved in cytochrome c synthesis; Belongs to the DsbD family.


ensembl_gene_id: HI_1455
symbol: msrAB
gene_biotype: protein_coding
description:
  Peptide methionine sulfoxide reductase (msrA); Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity).


ensembl_gene_id: HI_1457
symbol: HI_1457
gene_biotype: protein_coding
description:
  Opacity protein, putative; Similar to PID:2367659 percent identity: 34.32; identified by sequence similarity; putative; Belongs to the opacity porin family.


ensembl_gene_id: HI_1459
symbol: HI_1459
gene_biotype: protein_coding
description:
  Sigma factor, putative; Similar to GB:AL009126 percent identity: 26.75; identified by sequence similarity; putative; Belongs to the sigma-70 factor family. ECF subfamily.


ensembl_gene_id: HI_1462
symbol: HI_1462
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:U00096 SP:P77211 PID:1778487 PID:1786785 percent identity: 24.32; identified by sequence similarity; putative; Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.


ensembl_gene_id: HI_1462.2
symbol: HI_1462.2
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:U00096 PID:1788681 percent identity: 40.26; identified by sequence similarity; putative.


ensembl_gene_id: HI_1463
symbol: HI_1463
gene_biotype: protein_coding
description:
  mrsA protein (mrsA); Similar to GB:L12968 SP:P31120 GB:U01376 PID:290443 PID:606114 percent identity: 73.26; identified by sequence similarity; putative.


ensembl_gene_id: HI_1464
symbol: HI_1464
gene_biotype: protein_coding
description:
  Dihydropteroate synthase (folP-2); Similar to GB:L06494 SP:P26282 GB:U01376 GB:X68776 GB:X68777 percent identity: 54.15; identified by sequence similarity; putative.


ensembl_gene_id: HI_1465
symbol: HI_1465
gene_biotype: protein_coding
description:
  Cell division ftsH-related protein; Similar to GB:M83138 SP:P28691 GB:U01376 PID:146028 PID:606116 percent identity: 77.66; identified by sequence similarity; putative; In the C-terminal section; belongs to the peptidase M41 family.


ensembl_gene_id: HI_1466.1
symbol: HI_1466.1
gene_biotype: protein_coding
description:
  Predicted coding region HI1466.1; Brute Force ORF; identified by GeneMark; putative; Belongs to the TonB-dependent receptor family.


ensembl_gene_id: HI_1467
symbol: HI_1467
gene_biotype: protein_coding
description:
  ABC transporter, ATP-binding protein; Similar to SP:Q50614 PID:1483552 percent identity: 36.97; identified by sequence similarity; putative.


ensembl_gene_id: HI_1468
symbol: HI_1468
gene_biotype: protein_coding
description:
  Ribosomal protein S15 (rpS15); Similar to GB:J02638 SP:P02371 GB:M14425 GB:X00761 GB:X01073 percent identity: 80.90; identified by sequence similarity; putative.


ensembl_gene_id: HI_1470
symbol: HI_1470
gene_biotype: protein_coding
description:
  Iron chelatin ABC transporter, ATP-binding protein, putative; Similar to GB:AE000511 SP:O05732 PID:2072456 PID:2314024 percent identity: 38.60; identified by sequence similarity; putative.


ensembl_gene_id: HI_1471
symbol: HI_1471
gene_biotype: protein_coding
description:
  Iron chelatin ABC transporter, permease protein, putative; Probably part of a binding-protein-dependent transport system. Probably responsible for the translocation of the substrate across the membrane.


ensembl_gene_id: HI_1472
symbol: HI_1472
gene_biotype: protein_coding
description:
  Iron chelatin ABC transporter, periplasmic-binding protein, putative; Similar to GB:AE000511 PID:2314746 percent identity: 25.44; identified by sequence similarity; putative.


ensembl_gene_id: HI_1473
symbol: modD
gene_biotype: protein_coding
description:
  Molybdenum transport system protein (modD); Similar to SP:P94777 PID:1816657 percent identity: 43.21; identified by sequence similarity; putative; Belongs to the NadC/ModD family.


ensembl_gene_id: HI_1474
symbol: HI_1474
gene_biotype: protein_coding
description:
  ABC transporter, ATP-binding protein; Similar to GB:AE000511 PID:2313950 percent identity: 38.71; identified by sequence similarity; putative; Belongs to the ABC transporter superfamily.


ensembl_gene_id: HI_1476
symbol: HI_1476
gene_biotype: protein_coding
description:
  Transcriptional regulatory protein; Similar to SP:Q37906 PID:403436 percent identity: 28.43; identified by sequence similarity; putative.


ensembl_gene_id: HI_1477
symbol: nlp
gene_biotype: protein_coding
description:
  DNA-binding protein (ner); Negative regulator of transcription starting from the Pe and Pc promoters of Mu. Also negatively regulates its own gene transcription (By similarity).


ensembl_gene_id: HI_1478
symbol: HI_1478
gene_biotype: protein_coding
description:
  Transposase (muA); This transposase is essential for integration, replication- transposition, and excision of Mu-like viral DNA.


ensembl_gene_id: HI_1481
symbol: HI_1481
gene_biotype: protein_coding
description:
  DNA transposition protein (muB); This protein is a non-specific DNA-binding and ATP- hydrolyzing protein essential for bacteriophage integration and replication.


ensembl_gene_id: HI_1483
symbol: HI_1483
gene_biotype: protein_coding
description:
  Host-nuclease inhibitor protein (gam); Protects linear double-stranded DNA of Mu genome from exonuclease degradation.


ensembl_gene_id: HI_1488
symbol: HI_1488
gene_biotype: protein_coding
description:
  E16 protein, putative; Similar to PID:215574 percent identity: 29.53; identified by sequence similarity; putative; To phage Mu protein gp16.


ensembl_gene_id: HI_1490
symbol: HI_1490
gene_biotype: protein_coding
description:
  Positive regulator of late transcription {Bacteriophage mu); Similar to SP:P06022 PID:15812 PID:215521 PID:215582 percent identity: 44.26; identified by sequence similarity; putative.


ensembl_gene_id: HI_1494
symbol: HI_1494
gene_biotype: protein_coding
description:
  N-acetylmuramoyl-L-alanine amidase; Similar to SP:P20331 PID:15695 percent identity: 43.88; identified by sequence similarity; putative; To phage T3 and T7 N-acetylmuramoyl-L-alanine amidases.


ensembl_gene_id: HI_1497
symbol: HI_1497
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to SP:Q06424 PID:288658 percent identity: 36.21; identified by sequence similarity; putative.


ensembl_gene_id: HI_1499
symbol: HI_1499
gene_biotype: protein_coding
description:
  Predicted coding region HI1499; Hypothetical protein; identified by GeneMark; putative; To phage Mu protein gp27.


ensembl_gene_id: HI_1500
symbol: HI_1500
gene_biotype: protein_coding
description:
  Predicted coding region HI1500; Hypothetical protein; identified by GeneMark; putative; To phage Mu protein gp28.


ensembl_gene_id: HI_1501
symbol: HI_1501
gene_biotype: protein_coding
description:
  Predicted coding region HI1501; Hypothetical protein; identified by GeneMark; putative; To phage Mu protein gp29.


ensembl_gene_id: HI_1503
symbol: HI_1503
gene_biotype: protein_coding
description:
  G protein (muG-1); Similar to SP:Q01261 PID:215535 percent identity: 38.30; identified by sequence similarity; putative; To phage Mu protein G.


ensembl_gene_id: HI_1505
symbol: HI_1505
gene_biotype: protein_coding
description:
  Predicted coding region HI1505; Hypothetical protein; identified by GeneMark; putative; To phage Mu protein T.


ensembl_gene_id: HI_1508
symbol: HI_1508
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to PID:2353778 percent identity: 80.53; identified by sequence similarity; putative; To phage Mu protein gp36.


ensembl_gene_id: HI_1509
symbol: HI_1509
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to PID:2353777 percent identity: 79.75; identified by sequence similarity; putative; To phage Mu protein gp37.


ensembl_gene_id: HI_1510
symbol: HI_1510
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GP:1834290 percent identity: 44.64; identified by sequence similarity; putative; To phage Mu protein gp38.


ensembl_gene_id: HI_1512
symbol: HI_1512
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to PID:1834292 percent identity: 38.79; identified by sequence similarity; putative; To phage Mu protein M.


ensembl_gene_id: HI_1513
symbol: HI_1513
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to PID:1834293 percent identity: 50.89; identified by sequence similarity; putative; To phage Mu protein gp41.


ensembl_gene_id: HI_1515
symbol: HI_1515
gene_biotype: protein_coding
description:
  64 kDa virion protein (muN); Similar to SP:P08557 PID:15105 percent identity: 31.48; identified by sequence similarity; putative; To phage Mu protein N.


ensembl_gene_id: HI_1518
symbol: HI_1518
gene_biotype: protein_coding
description:
  Predicted coding region HI1518; Hypothetical protein; identified by GeneMark; putative; To phage Mu protein gp45.


ensembl_gene_id: HI_1519
symbol: HI_1519
gene_biotype: protein_coding
description:
  Predicted coding region HI1519; Hypothetical protein; identified by GeneMark; putative; To phage Mu protein gp46.


ensembl_gene_id: HI_1520
symbol: HI_1520
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:U00096 PID:1787398 percent identity: 33.47; identified by sequence similarity; putative; Belongs to the Mu gp47/PBSX XkdT family.


ensembl_gene_id: HI_1521
symbol: HI_1521
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:U00096 PID:1787399 percent identity: 27.37; identified by sequence similarity; putative; To phage Mu protein gp48 an E.coli YmfQ.


ensembl_gene_id: HI_1522
symbol: HI_1522
gene_biotype: protein_coding
description:
  Predicted coding region HI1522; Hypothetical protein; identified by GeneMark; putative; To phage Mu protein S.


ensembl_gene_id: HI_1522.1
symbol: HI_1522.1
gene_biotype: protein_coding
description:
  Predicted coding region HI1522.1; Hypothetical protein; identified by GeneMark; putative; Belongs to the com family.


ensembl_gene_id: HI_1525
symbol: HI_1525
gene_biotype: protein_coding
description:
  Molybdate-binding periplasmic protein, putative; Probably involved in the binding-dependent system; Belongs to the bacterial solute-binding protein ModA family.


ensembl_gene_id: HI_1526
symbol: hldE
gene_biotype: protein_coding
description:
  ADP-heptose synthase (rfaE); Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7- phosphate at the C-1 position to selectively form D-glycero-beta-D- manno-heptose-1,7-bisphosphate; In the N-terminal section; belongs to the carbohydrate kinase PfkB family.


ensembl_gene_id: HI_1527
symbol: lpxL
gene_biotype: protein_coding
description:
  Lipid A biosynthesis lauroyl acyltransferase (htrB); Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(lauroyl)-lipid IV(A).


ensembl_gene_id: HI_1528
symbol: parE
gene_biotype: protein_coding
description:
  Topoisomerase IV, subunit B (parE); Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 1 subfamily.


ensembl_gene_id: HI_1529
symbol: parC
gene_biotype: protein_coding
description:
  Topoisomerase IV, subunit A (parC); Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily.


ensembl_gene_id: HI_1530
symbol: gltS
gene_biotype: protein_coding
description:
  Glutamate permease (gltS); Catalyzes the sodium-dependent transport of glutamate. Belongs to the glutamate:Na(+) symporter (ESS) (TC 2.A.27) family.


ensembl_gene_id: HI_1531
symbol: rimK
gene_biotype: protein_coding
description:
  Ribosomal protein S6 modification protein (rimK); Similar to SP:P17116 GB:X15859 PID:42747 GB:U00096 PID:1651386 percent identity: 45.55; identified by sequence similarity; putative.


ensembl_gene_id: HI_1532
symbol: grxA
gene_biotype: protein_coding
description:
  Glutaredoxin (grx); Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins (By similarity).


ensembl_gene_id: HI_1533
symbol: fabB
gene_biotype: protein_coding
description:
  beta-ketoacyl-ACP synthase I (fabB); Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids (By similarity).


ensembl_gene_id: HI_1534
symbol: HI_1534
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:AE000783 percent identity: 32.57; identified by sequence similarity; putative.


ensembl_gene_id: HI_1535
symbol: mnmC
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34; In the N-terminal section; belongs to the methyltransferase superfamily. tRNA (mnm(5)s(2)U34)-methyltransferase family.


ensembl_gene_id: HI_1536
symbol: HI_1536
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:U00096 PID:1788664 percent identity: 50.93; identified by sequence similarity; putative.


ensembl_gene_id: HI_1537
symbol: licA
gene_biotype: protein_coding
description:
  Lic-1 operon protein (licA); Mediates phase variation of the LPS epitopes. Phase variation of H.influenza LPS epitopes expressed by LicA is determined by a translational switch (By similarity).


ensembl_gene_id: HI_1538
symbol: licB
gene_biotype: protein_coding
description:
  Lic-1 operon protein (licB); Similar to GB:M27280 SP:P14182 percent identity: 99.01; identified by sequence similarity; putative.


ensembl_gene_id: HI_1539
symbol: licC
gene_biotype: protein_coding
description:
  Lic-1 operon protein (licC); Similar to GB:M27280 SP:P14183 percent identity: 96.46; identified by sequence similarity; putative.


ensembl_gene_id: HI_1540
symbol: licD
gene_biotype: protein_coding
description:
  Lic-1 operon protein (licD); Transfers phosphorylcholine (ChoP) from choline diphosphonucleoside to the lipopolysaccharide (LPS). Belongs to the LicD transferase family.


ensembl_gene_id: HI_1541
symbol: sppA
gene_biotype: protein_coding
description:
  Protease IV (sppA); Digests cleaved signal peptides in vitro, its in vivo function is unknown. This activity is necessary to maintain proper secretion of mature proteins across the membrane (By similarity).


ensembl_gene_id: HI_1542
symbol: HI_1542
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to PID:2253239 percent identity: 50.27; identified by sequence similarity; putative; Belongs to the nitroreductase family.


ensembl_gene_id: HI_1543
symbol: HI_1543
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to GB:U00096 SP:P75915 PID:1787272 percent identity: 39.78; identified by sequence similarity; putative; Belongs to the TorD/DmsD family.


ensembl_gene_id: HI_1544
symbol: HI_1544
gene_biotype: protein_coding
description:
  NAD(P)H oxidoreductase, putative; Similar to SP:Q64669 PID:595518 percent identity: 35.87; identified by sequence similarity; putative; Belongs to the NAD(P)H dehydrogenase (quinone) family.


ensembl_gene_id: HI_1545
symbol: sstT
gene_biotype: protein_coding
description:
  Sodium:dicarboxylate symporter protein; Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system). Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.


ensembl_gene_id: HI_1546
symbol: HI_1546
gene_biotype: protein_coding
description:
  impA protein, putative; Similar to percent identity: 34.26; identified by sequence similarity; putative; Belongs to the peptidase S24 family.


ensembl_gene_id: HI_1547
symbol: aroG
gene_biotype: protein_coding
description:
  Phospho-2-dehydro-3-deoxyheptonate aldolase (phenylalanine repressible) (aroG); Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP).


ensembl_gene_id: HI_1548
symbol: lolE
gene_biotype: protein_coding
description:
  Conserved hypothetical transmembrane protein; Part of an ATP-dependent transport system LolCDE responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprotein) and of LolA (By similarity); Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.


ensembl_gene_id: HI_1549
symbol: lolD
gene_biotype: protein_coding
description:
  ABC transporter, ATP-binding protein; Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.


ensembl_gene_id: HI_1550
symbol: bioD2
gene_biotype: protein_coding
description:
  Dethiobiotin synthase (bioD-2); Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring.


ensembl_gene_id: HI_1551
symbol: bioC
gene_biotype: protein_coding
description:
  Biotin synthesis protein, putative; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway.


ensembl_gene_id: HI_1553
symbol: bioF
gene_biotype: protein_coding
description:
  8-amino-7-oxononanoate synthase (bioF); Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.


ensembl_gene_id: HI_1554
symbol: bioA
gene_biotype: protein_coding
description:
  Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (bioA); Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.


ensembl_gene_id: HI_1556
symbol: HI_1556
gene_biotype: protein_coding
description:
  2-hydroxyacid dehydrogenase; Similar to GB:AE000511 PID:2313177 percent identity: 41.64; identified by sequence similarity; putative; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.


ensembl_gene_id: HI_1557
symbol: kdsA
gene_biotype: protein_coding
description:
  2-dehydro-3-deoxyphosphooctonate aldolase (kdsA); Similar to SP:P17579 GB:X05552 PID:940498 PID:968934 GB:U00096 percent identity: 81.63; identified by sequence similarity; putative; Belongs to the KdsA family.


ensembl_gene_id: HI_1558
symbol: HI_1558
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Similar to SP:P20101 GB:X05552 PID:41872 PID:1008040 GB:U00096 percent identity: 40.83; identified by sequence similarity; putative; Belongs to the UPF0162 family.


ensembl_gene_id: HI_1559
symbol: prmC
gene_biotype: protein_coding
description:
  hemK protein (hemK); Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif; Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.


ensembl_gene_id: HI_1561
symbol: prfA
gene_biotype: protein_coding
description:
  Peptide chain release factor 1 (prfA); Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.


ensembl_gene_id: HI_1563
symbol: epmC
gene_biotype: protein_coding
description:
  Conserved hypothetical protein; Is involved in the final hydroxylation step of the post- translational modification of translation elongation factor P (EF-P) on 'Lys-34'. Acts after beta-lysylation of 'Lys-34' by EpmA and EpmB. EpmC adds an oxygen atom to the C5 position of 'Lys-34' and does not modify the added beta-lysine (By similarity).


ensembl_gene_id: HI_1565
symbol: HI_1565
gene_biotype: protein_coding
description:
  Hemoglobin-binding protein; Similar to PID:1000292 PID:984513 percent identity: 54.76; identified by sequence similarity; putative.


ensembl_gene_id: HI_1567
symbol: HI_1567
gene_biotype: protein_coding
description:
  TonB-dependent receptor, putative; Acts as a receptor for hemoglobin or the hemoglobin/haptoglobin complex of the human host and is required for heme uptake.


ensembl_gene_id: HI_1568
symbol: HI_1568
gene_biotype: protein_coding
description:
  G protein (muG-2); Similar to SP:Q01261 PID:215535 percent identity: 33.33; identified by sequence similarity; putative; To phage Mu protein G.


ensembl_gene_id: HI_1573
symbol: pykA
gene_biotype: protein_coding
description:
  Pyruvate kinase, type II (pykA); Similar to GB:M63703 SP:P21599 GB:M87660 PID:147459 PID:146878 percent identity: 77.24; identified by sequence similarity; putative; Belongs to the pyruvate kinase family.


ensembl_gene_id: HI_1574
symbol: dnaB
gene_biotype: protein_coding
description:
  Replicative DNA helicase (dnaB); Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins.


ensembl_gene_id: HI_1575
symbol: alr
gene_biotype: protein_coding
description:
  Alanine racemase, biosynthetic (alr); Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family.


