# geneInfo

ensembl_gene_id: ENSLOCP00000000014
symbol: W5LV57_LEPOC
gene_biotype: protein_coding
description:
  Myosin_tail_1 domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.


ensembl_gene_id: ENSLOCP00000000015
symbol: W5LV58_LEPOC
gene_biotype: protein_coding
description:
  Myosin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.


ensembl_gene_id: ENSLOCP00000000023
symbol: LOC102691054
gene_biotype: protein_coding
description:
  Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.


ensembl_gene_id: ENSLOCP00000000030
symbol: kif20b
gene_biotype: protein_coding
description:
  Kinesin family member 20Bb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.


ensembl_gene_id: ENSLOCP00000000062
symbol: LOC102698801
gene_biotype: protein_coding
description:
  G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.


ensembl_gene_id: ENSLOCP00000000167
symbol: katnal1
gene_biotype: protein_coding
description:
  Katanin p60 ATPase-containing subunit A-like 1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 1 sub-subfamily.


ensembl_gene_id: ENSLOCP00000000249
symbol: KCNK4
gene_biotype: protein_coding
description:
  Potassium two pore domain channel subfamily K member 4; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.


ensembl_gene_id: ENSLOCP00000000275
symbol: LOC102686513
gene_biotype: protein_coding
description:
  Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.


ensembl_gene_id: ENSLOCP00000000350
symbol: LOC102698183
gene_biotype: protein_coding
description:
  Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family.


ensembl_gene_id: ENSLOCP00000000370
symbol: AVPR2
gene_biotype: protein_coding
description:
  Arginine vasopressin receptor 2; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.


ensembl_gene_id: ENSLOCP00000000424
symbol: ARCN1
gene_biotype: protein_coding
description:
  Coatomer subunit delta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.


ensembl_gene_id: ENSLOCP00000000426
symbol: LOC107076226
gene_biotype: protein_coding
description:
  Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.


ensembl_gene_id: ENSLOCP00000000467
symbol: W5LXH1_LEPOC
gene_biotype: protein_coding
description:
  V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.


ensembl_gene_id: ENSLOCP00000000480
symbol: MAF
gene_biotype: protein_coding
description:
  V-maf avian musculoaponeurotic fibrosarcoma oncogene homolog b (paralog b); Belongs to the bZIP family.


ensembl_gene_id: ENSLOCP00000000507
symbol: usb1
gene_biotype: protein_coding
description:
  U6 snRNA phosphodiesterase; Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA; Belongs to the 2H phosphoesterase superfamily. USB1 family.


ensembl_gene_id: ENSLOCP00000000552
symbol: GJD4
gene_biotype: protein_coding
description:
  Gap junction protein delta 4; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Belongs to the connexin family.


ensembl_gene_id: ENSLOCP00000000640
symbol: kcnk2
gene_biotype: protein_coding
description:
  Potassium channel, subfamily K, member 2a; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.


ensembl_gene_id: ENSLOCP00000000647
symbol: W5LWZ0_LEPOC
gene_biotype: protein_coding
description:
  Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.


ensembl_gene_id: ENSLOCP00000000651
symbol: LOC102693418
gene_biotype: protein_coding
description:
  Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs; Belongs to the argonaute family. Ago subfamily.


ensembl_gene_id: ENSLOCP00000000679
symbol: fut11
gene_biotype: protein_coding
description:
  Alpha-(1,3)-fucosyltransferase; Probable fucosyltransferase; Belongs to the glycosyltransferase 10 family.


ensembl_gene_id: ENSLOCP00000000680
symbol: adcy2
gene_biotype: protein_coding
description:
  Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.


ensembl_gene_id: ENSLOCP00000000735
symbol: pip4p1
gene_biotype: protein_coding
description:
  Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).


ensembl_gene_id: ENSLOCP00000000766
symbol: MED4
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 4; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.


ensembl_gene_id: ENSLOCP00000000767
symbol: asic4
gene_biotype: protein_coding
description:
  Acid-sensing (proton-gated) ion channel family member 4a; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.


ensembl_gene_id: ENSLOCP00000000773
symbol: W5LXB6_LEPOC
gene_biotype: protein_coding
description:
  Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family.


ensembl_gene_id: ENSLOCP00000000784
symbol: ATP11B
gene_biotype: protein_coding
description:
  Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.


ensembl_gene_id: ENSLOCP00000000805
symbol: gng7
gene_biotype: protein_coding
description:
  Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.


ensembl_gene_id: ENSLOCP00000000848
symbol: fuca2
gene_biotype: protein_coding
description:
  Alpha-L-fucosidase; Alpha-L-fucosidase is responsible for hydrolyzing the alpha- 1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.


ensembl_gene_id: ENSLOCP00000000852
symbol: LOC102693325
gene_biotype: protein_coding
description:
  V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.


ensembl_gene_id: ENSLOCP00000000912
symbol: W5LXQ5_LEPOC
gene_biotype: protein_coding
description:
  Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.


ensembl_gene_id: ENSLOCP00000000920
symbol: W5LXR3_LEPOC
gene_biotype: protein_coding
description:
  Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.


ensembl_gene_id: ENSLOCP00000000922
symbol: cct7
gene_biotype: protein_coding
description:
  T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.


ensembl_gene_id: ENSLOCP00000000939
symbol: W5LXT2_LEPOC
gene_biotype: protein_coding
description:
  Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.


ensembl_gene_id: ENSLOCP00000000961
symbol: bpgm
gene_biotype: protein_coding
description:
  Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily.


ensembl_gene_id: ENSLOCP00000000963
symbol: coq4
gene_biotype: protein_coding
description:
  Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial; Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides; Belongs to the COQ4 family.


ensembl_gene_id: ENSLOCP00000001010
symbol: LOC102694151
gene_biotype: protein_coding
description:
  Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis.


ensembl_gene_id: ENSLOCP00000001030
symbol: LOC102693466
gene_biotype: protein_coding
description:
  EH-domain containing 1b; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.


ensembl_gene_id: ENSLOCP00000001048
symbol: eif3f
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 3 subunit F; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.


ensembl_gene_id: ENSLOCP00000001089
symbol: dnm1l
gene_biotype: protein_coding
description:
  Dynamin 1-like; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.


ensembl_gene_id: ENSLOCP00000001095
symbol: ST8SIA1
gene_biotype: protein_coding
description:
  ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1; Belongs to the glycosyltransferase 29 family.


ensembl_gene_id: ENSLOCP00000001107
symbol: W5LYA0_LEPOC
gene_biotype: protein_coding
description:
  Myosin heavy chain 7-like; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.


ensembl_gene_id: ENSLOCP00000001112
symbol: serpinh1
gene_biotype: protein_coding
description:
  Serpin peptidase inhibitor, clade H (heat shock protein 47), member 1a; Belongs to the serpin family.


ensembl_gene_id: ENSLOCP00000001160
symbol: cat
gene_biotype: protein_coding
description:
  Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.


ensembl_gene_id: ENSLOCP00000001250
symbol: nsun5
gene_biotype: protein_coding
description:
  NOP2/Sun RNA methyltransferase 5; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.


ensembl_gene_id: ENSLOCP00000001268
symbol: ak2
gene_biotype: protein_coding
description:
  Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.


ensembl_gene_id: ENSLOCP00000001277
symbol: pik3ca
gene_biotype: protein_coding
description:
  Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha; Belongs to the PI3/PI4-kinase family.


ensembl_gene_id: ENSLOCP00000001351
symbol: TUBB3
gene_biotype: protein_coding
description:
  Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family.


ensembl_gene_id: ENSLOCP00000001376
symbol: hsd17b12
gene_biotype: protein_coding
description:
  Hydroxysteroid (17-beta) dehydrogenase 12a; Belongs to the short-chain dehydrogenases/reductases (SDR) family.


ensembl_gene_id: ENSLOCP00000001423
symbol: kynu
gene_biotype: protein_coding
description:
  Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.


ensembl_gene_id: ENSLOCP00000001426
symbol: LOC102687462
gene_biotype: protein_coding
description:
  Cytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.


ensembl_gene_id: ENSLOCP00000001450
symbol: rag1
gene_biotype: protein_coding
description:
  V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break  [...]


ensembl_gene_id: ENSLOCP00000001458
symbol: W5LZA1_LEPOC
gene_biotype: protein_coding
description:
  Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes.


ensembl_gene_id: ENSLOCP00000001462
symbol: exoc6b
gene_biotype: protein_coding
description:
  Exocyst complex component; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.


ensembl_gene_id: ENSLOCP00000001481
symbol: nfic
gene_biotype: protein_coding
description:
  Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.


ensembl_gene_id: ENSLOCP00000001485
symbol: W5LZC8_LEPOC
gene_biotype: protein_coding
description:
  Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.


ensembl_gene_id: ENSLOCP00000001515
symbol: dohh
gene_biotype: protein_coding
description:
  Deoxyhypusine hydroxylase; Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L- lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor; Belongs to the deoxyhypusine hydroxylase family.


ensembl_gene_id: ENSLOCP00000001524
symbol: apip
gene_biotype: protein_coding
description:
  Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway. May play a role in apoptosis.


ensembl_gene_id: ENSLOCP00000001533
symbol: acvr2a
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.


ensembl_gene_id: ENSLOCP00000001536
symbol: LOC102684903
gene_biotype: protein_coding
description:
  Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.


ensembl_gene_id: ENSLOCP00000001558
symbol: pde6d
gene_biotype: protein_coding
description:
  Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta; Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide [...]


ensembl_gene_id: ENSLOCP00000001564
symbol: nip7
gene_biotype: protein_coding
description:
  60S ribosome subunit biogenesis protein NIP7 homolog; Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly; Belongs to the NIP7 family.


ensembl_gene_id: ENSLOCP00000001571
symbol: orc4
gene_biotype: protein_coding
description:
  Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family.


ensembl_gene_id: ENSLOCP00000001575
symbol: W5LZL8_LEPOC
gene_biotype: protein_coding
description:
  DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family.


ensembl_gene_id: ENSLOCP00000001623
symbol: W5LZR6_LEPOC
gene_biotype: protein_coding
description:
  Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.


ensembl_gene_id: ENSLOCP00000001652
symbol: dync1li1
gene_biotype: protein_coding
description:
  Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.


ensembl_gene_id: ENSLOCP00000001673
symbol: hspb2
gene_biotype: protein_coding
description:
  Heat shock protein, alpha-crystallin-related, b2; Belongs to the small heat shock protein (HSP20) family.


ensembl_gene_id: ENSLOCP00000001687
symbol: rpn2
gene_biotype: protein_coding
description:
  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...]


ensembl_gene_id: ENSLOCP00000001693
symbol: pisd
gene_biotype: protein_coding
description:
  Phosphatidylserine decarboxylase proenzyme, mitochondrial; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.


ensembl_gene_id: ENSLOCP00000001728
symbol: dlat
gene_biotype: protein_coding
description:
  Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).


ensembl_gene_id: ENSLOCP00000001733
symbol: ncbp2
gene_biotype: protein_coding
description:
  Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...]


ensembl_gene_id: ENSLOCP00000001736
symbol: KIF5C
gene_biotype: protein_coding
description:
  Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.


ensembl_gene_id: ENSLOCP00000001823
symbol: atp2c1
gene_biotype: protein_coding
description:
  Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.


ensembl_gene_id: ENSLOCP00000001836
symbol: W5M0C9_LEPOC
gene_biotype: protein_coding
description:
  Citron rho-interacting serine/threonine kinase a; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.


ensembl_gene_id: ENSLOCP00000001863
symbol: kcnq2
gene_biotype: protein_coding
description:
  Potassium voltage-gated channel, KQT-like subfamily, member 2a; Belongs to the potassium channel family.


ensembl_gene_id: ENSLOCP00000001870
symbol: atp6v1b1
gene_biotype: protein_coding
description:
  Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family.


ensembl_gene_id: ENSLOCP00000001876
symbol: W5M0G9_LEPOC
gene_biotype: protein_coding
description:
  5-hydroxyisourate hydrolase; Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.


ensembl_gene_id: ENSLOCP00000001882
symbol: trappc3
gene_biotype: protein_coding
description:
  Trafficking protein particle complex subunit; May play a role in vesicular transport from endoplasmic reticulum to Golgi.


ensembl_gene_id: ENSLOCP00000001890
symbol: arpc5
gene_biotype: protein_coding
description:
  Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.


ensembl_gene_id: ENSLOCP00000001906
symbol: W5M0J9_LEPOC
gene_biotype: protein_coding
description:
  Voltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents.


ensembl_gene_id: ENSLOCP00000001908
symbol: por
gene_biotype: protein_coding
description:
  NADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5; In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.


ensembl_gene_id: ENSLOCP00000001937
symbol: rplp0
gene_biotype: protein_coding
description:
  60S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10.


ensembl_gene_id: ENSLOCP00000001944
symbol: riok3
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase RIO3; Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.


ensembl_gene_id: ENSLOCP00000001964
symbol: RTEL1
gene_biotype: protein_coding
description:
  Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by  [...]


ensembl_gene_id: ENSLOCP00000001980
symbol: ctu1
gene_biotype: protein_coding
description:
  Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.


ensembl_gene_id: ENSLOCP00000002005
symbol: W5M0U8_LEPOC
gene_biotype: protein_coding
description:
  Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.


ensembl_gene_id: ENSLOCP00000002046
symbol: W5M0Y9_LEPOC
gene_biotype: protein_coding
description:
  Carnitine palmitoyltransferase 1Aa (liver); Belongs to the carnitine/choline acetyltransferase family.


ensembl_gene_id: ENSLOCP00000002063
symbol: trmt1l
gene_biotype: protein_coding
description:
  tRNA methyltransferase 1-like; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.


ensembl_gene_id: ENSLOCP00000002077
symbol: acmsd
gene_biotype: protein_coding
description:
  2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). Belongs to the metallo-dependent hydrolases superfamily.


ensembl_gene_id: ENSLOCP00000002081
symbol: polr3g
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerase III subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.


ensembl_gene_id: ENSLOCP00000002082
symbol: pex12
gene_biotype: protein_coding
description:
  Peroxisome assembly protein 12; Required for protein import into peroxisomes. Belongs to the pex2/pex10/pex12 family.


ensembl_gene_id: ENSLOCP00000002086
symbol: LOC102682536
gene_biotype: protein_coding
description:
  Zgc:63587; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.


ensembl_gene_id: ENSLOCP00000002092
symbol: lmf1
gene_biotype: protein_coding
description:
  Lipase maturation factor; Involved in the maturation of specific proteins in the endoplasmic reticulum; Belongs to the lipase maturation factor family.


ensembl_gene_id: ENSLOCP00000002101
symbol: med16
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 16; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.


ensembl_gene_id: ENSLOCP00000002104
symbol: serp1
gene_biotype: protein_coding
description:
  Stress-associated endoplasmic reticulum protein; May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation. Belongs to the RAMP4 family.


ensembl_gene_id: ENSLOCP00000002120
symbol: eif2a
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 2A; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl- tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.


ensembl_gene_id: ENSLOCP00000002139
symbol: pemt
gene_biotype: protein_coding
description:
  Phosphatidylethanolamine N-methyltransferase; Catalyzes the three sequential steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME), PMME to phosphatidyldimethylethanolamine (PDME), and PDME to phosphatidylcholine (PC); Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.


ensembl_gene_id: ENSLOCP00000002172
symbol: med9
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 9; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.


ensembl_gene_id: ENSLOCP00000002186
symbol: W5M1C9_LEPOC
gene_biotype: protein_coding
description:
  tRNA-splicing endonuclease subunit Sen34; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structura [...]


ensembl_gene_id: ENSLOCP00000002189
symbol: pabpc4
gene_biotype: protein_coding
description:
  Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family.


ensembl_gene_id: ENSLOCP00000002203
symbol: SIAH2
gene_biotype: protein_coding
description:
  E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.


ensembl_gene_id: ENSLOCP00000002208
symbol: W5M1F0_LEPOC
gene_biotype: protein_coding
description:
  Protein HIRA; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family.


ensembl_gene_id: ENSLOCP00000002215
symbol: W5M1F7_LEPOC
gene_biotype: protein_coding
description:
  Coatomer subunit alpha; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.


ensembl_gene_id: ENSLOCP00000002224
symbol: ptpn4
gene_biotype: protein_coding
description:
  Tyrosine-protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily.


ensembl_gene_id: ENSLOCP00000002246
symbol: mpv17l2
gene_biotype: protein_coding
description:
  MPV17 mitochondrial membrane protein-like 2; Belongs to the peroxisomal membrane protein PXMP2/4 family.


ensembl_gene_id: ENSLOCP00000002262
symbol: W5M1K4_LEPOC
gene_biotype: protein_coding
description:
  Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.


ensembl_gene_id: ENSLOCP00000002273
symbol: ufc1
gene_biotype: protein_coding
description:
  Ubiquitin-fold modifier-conjugating enzyme 1; E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage.


ensembl_gene_id: ENSLOCP00000002283
symbol: W5M1M5_LEPOC
gene_biotype: protein_coding
description:
  Beta-1,4-N-acetylgalactosaminyltransferase; Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'- diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans.


ensembl_gene_id: ENSLOCP00000002286
symbol: cda
gene_biotype: protein_coding
description:
  Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.


ensembl_gene_id: ENSLOCP00000002311
symbol: snrpd1
gene_biotype: protein_coding
description:
  Small nuclear ribonucleoprotein Sm D1; Essential for pre-mRNA splicing. Implicated in the formation of stable, biologically active snRNP structures. Belongs to the snRNP core protein family.


ensembl_gene_id: ENSLOCP00000002321
symbol: LOC102694849
gene_biotype: protein_coding
description:
  Solute carrier family 8 member 4b; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.


ensembl_gene_id: ENSLOCP00000002347
symbol: lsm4
gene_biotype: protein_coding
description:
  U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA.


ensembl_gene_id: ENSLOCP00000002353
symbol: jph2
gene_biotype: protein_coding
description:
  Junctophilin; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.


ensembl_gene_id: ENSLOCP00000002354
symbol: W5M1U6_LEPOC
gene_biotype: protein_coding
description:
  Rho-associated, coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.


ensembl_gene_id: ENSLOCP00000002360
symbol: mapk1
gene_biotype: protein_coding
description:
  Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.


ensembl_gene_id: ENSLOCP00000002376
symbol: rad51d
gene_biotype: protein_coding
description:
  DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents; Belongs to the RecA family. RAD51 subfamily.


ensembl_gene_id: ENSLOCP00000002387
symbol: W5M1X9_LEPOC
gene_biotype: protein_coding
description:
  DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.


ensembl_gene_id: ENSLOCP00000002391
symbol: trit1
gene_biotype: protein_coding
description:
  tRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37; Belongs to the IPP transferase family.


ensembl_gene_id: ENSLOCP00000002417
symbol: dhrs7b
gene_biotype: protein_coding
description:
  Dehydrogenase/reductase (SDR family) member 7B; Belongs to the short-chain dehydrogenases/reductases (SDR) family.


ensembl_gene_id: ENSLOCP00000002452
symbol: LOC102691736
gene_biotype: protein_coding
description:
  Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.


ensembl_gene_id: ENSLOCP00000002463
symbol: W5M255_LEPOC
gene_biotype: protein_coding
description:
  Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.


ensembl_gene_id: ENSLOCP00000002490
symbol: slc2a10
gene_biotype: protein_coding
description:
  Solute carrier family 2 member 10; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.


ensembl_gene_id: ENSLOCP00000002507
symbol: LOC102690645
gene_biotype: protein_coding
description:
  Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.


ensembl_gene_id: ENSLOCP00000002527
symbol: hsd17b2
gene_biotype: protein_coding
description:
  Hydroxysteroid (17-beta) dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family.


ensembl_gene_id: ENSLOCP00000002550
symbol: KIF15
gene_biotype: protein_coding
description:
  Kinesin family member 15; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.


ensembl_gene_id: ENSLOCP00000002590
symbol: W5M2I2_LEPOC
gene_biotype: protein_coding
description:
  Serine/threonine-protein phosphatase 2A activator; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.


ensembl_gene_id: ENSLOCP00000002591
symbol: KIF27
gene_biotype: protein_coding
description:
  Kinesin family member 27; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.


ensembl_gene_id: ENSLOCP00000002612
symbol: W5M2K4_LEPOC
gene_biotype: protein_coding
description:
  DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]


ensembl_gene_id: ENSLOCP00000002668
symbol: slc2a8
gene_biotype: protein_coding
description:
  Solute carrier family 2 member 8; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.


ensembl_gene_id: ENSLOCP00000002673
symbol: gamt
gene_biotype: protein_coding
description:
  Guanidinoacetate N-methyltransferase; Converts guanidinoacetate to creatine, using S- adenosylmethionine as the methyl donor. Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family.


ensembl_gene_id: ENSLOCP00000002695
symbol: nubp2
gene_biotype: protein_coding
description:
  Cytosolic Fe-S cluster assembly factor NUBP2; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.


ensembl_gene_id: ENSLOCP00000002709
symbol: lipt2
gene_biotype: protein_coding
description:
  Putative lipoyltransferase 2, mitochondrial; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. Belongs to the LipB family.


ensembl_gene_id: ENSLOCP00000002712
symbol: tgfbr2
gene_biotype: protein_coding
description:
  TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]


ensembl_gene_id: ENSLOCP00000002719
symbol: med14
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.


ensembl_gene_id: ENSLOCP00000002736
symbol: LOC102685770
gene_biotype: protein_coding
description:
  Slc25a1 solute carrier family 25 member 1b; Belongs to the mitochondrial carrier (TC 2.A.29) family.


ensembl_gene_id: ENSLOCP00000002760
symbol: W5M302_LEPOC
gene_biotype: protein_coding
description:
  Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.


ensembl_gene_id: ENSLOCP00000002816
symbol: derl2
gene_biotype: protein_coding
description:
  Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.


ensembl_gene_id: ENSLOCP00000002842
symbol: LOC102697845
gene_biotype: protein_coding
description:
  Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.


ensembl_gene_id: ENSLOCP00000002853
symbol: EIF3I
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 3 subunit I; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.


ensembl_gene_id: ENSLOCP00000002914
symbol: ruvbl2
gene_biotype: protein_coding
description:
  RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.


ensembl_gene_id: ENSLOCP00000002955
symbol: adcy5
gene_biotype: protein_coding
description:
  Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.


ensembl_gene_id: ENSLOCP00000002961
symbol: trmt2a
gene_biotype: protein_coding
description:
  tRNA methyltransferase 2 homolog A; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.


ensembl_gene_id: ENSLOCP00000002971
symbol: W5M3L3_LEPOC
gene_biotype: protein_coding
description:
  Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors  [...]


ensembl_gene_id: ENSLOCP00000002972
symbol: cnn2
gene_biotype: protein_coding
description:
  Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.


ensembl_gene_id: ENSLOCP00000002973
symbol: W5M3L5_LEPOC
gene_biotype: protein_coding
description:
  Prefoldin subunit 4; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins; Belongs to the prefoldin subunit beta family.


ensembl_gene_id: ENSLOCP00000002993
symbol: hdac1
gene_biotype: protein_coding
description:
  Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.


ensembl_gene_id: ENSLOCP00000003030
symbol: ube2g1
gene_biotype: protein_coding
description:
  Ubiquitin-conjugating enzyme E2G 1a (UBC7 homolog, yeast); Belongs to the ubiquitin-conjugating enzyme family.


ensembl_gene_id: ENSLOCP00000003035
symbol: suclg1
gene_biotype: protein_coding
description:
  Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.


ensembl_gene_id: ENSLOCP00000003056
symbol: dph2
gene_biotype: protein_coding
description:
  2-(3-amino-3-carboxypropyl)histidine synthase subunit 2; Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2.


ensembl_gene_id: ENSLOCP00000003061
symbol: lrp5
gene_biotype: protein_coding
description:
  Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.


ensembl_gene_id: ENSLOCP00000003124
symbol: srp72
gene_biotype: protein_coding
description:
  Signal recognition particle subunit SRP72; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane; Belongs to the SRP72 family.


ensembl_gene_id: ENSLOCP00000003143
symbol: plcg2
gene_biotype: protein_coding
description:
  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.


ensembl_gene_id: ENSLOCP00000003163
symbol: LOC102697333
gene_biotype: protein_coding
description:
  Solute carrier family 24 member 6a; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.


ensembl_gene_id: ENSLOCP00000003213
symbol: W5M4A5_LEPOC
gene_biotype: protein_coding
description:
  Septin-type G domain-containing protein; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.


ensembl_gene_id: ENSLOCP00000003231
symbol: dctpp1
gene_biotype: protein_coding
description:
  dCTP pyrophosphatase 1; Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.


ensembl_gene_id: ENSLOCP00000003256
symbol: urm1
gene_biotype: protein_coding
description:
  Ubiquitin-related modifier 1; Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically [...]


ensembl_gene_id: ENSLOCP00000003268
symbol: tat
gene_biotype: protein_coding
description:
  Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate.


ensembl_gene_id: ENSLOCP00000003318
symbol: LOC102692597
gene_biotype: protein_coding
description:
  Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase; Belongs to the glycosyltransferase 43 family.


ensembl_gene_id: ENSLOCP00000003329
symbol: W5M4M1_LEPOC
gene_biotype: protein_coding
description:
  Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins; Belongs to the polypeptide deformylase family.


ensembl_gene_id: ENSLOCP00000003366
symbol: LOC102688329
gene_biotype: protein_coding
description:
  Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family.


ensembl_gene_id: ENSLOCP00000003393
symbol: LOC102687169
gene_biotype: protein_coding
description:
  Fatty acid binding protein 11b; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.


ensembl_gene_id: ENSLOCP00000003415
symbol: hspb1
gene_biotype: protein_coding
description:
  Heat shock protein, alpha-crystallin-related, 1; Belongs to the small heat shock protein (HSP20) family.


ensembl_gene_id: ENSLOCP00000003423
symbol: nat10
gene_biotype: protein_coding
description:
  RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.


ensembl_gene_id: ENSLOCP00000003428
symbol: ywhag
gene_biotype: protein_coding
description:
  3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 2; Belongs to the 14-3-3 family.


ensembl_gene_id: ENSLOCP00000003437
symbol: pop5
gene_biotype: protein_coding
description:
  Ribonuclease P/MRP protein subunit POP5; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.


ensembl_gene_id: ENSLOCP00000003444
symbol: gmpr
gene_biotype: protein_coding
description:
  GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.


ensembl_gene_id: ENSLOCP00000003472
symbol: ndufa8
gene_biotype: protein_coding
description:
  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.


ensembl_gene_id: ENSLOCP00000003473
symbol: trpc3
gene_biotype: protein_coding
description:
  Transient receptor potential cation channel, subfamily C, member 3; Belongs to the transient receptor (TC 1.A.4) family.


ensembl_gene_id: ENSLOCP00000003482
symbol: ebag9
gene_biotype: protein_coding
description:
  Estrogen receptor binding site associated antigen 9; May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases.


ensembl_gene_id: ENSLOCP00000003489
symbol: bbs7
gene_biotype: protein_coding
description:
  Bardet-Biedl syndrome 7 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function.


ensembl_gene_id: ENSLOCP00000003493
symbol: dpm1
gene_biotype: protein_coding
description:
  Dolichol-phosphate mannosyltransferase subunit 1; Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.


ensembl_gene_id: ENSLOCP00000003495
symbol: pik3c2a
gene_biotype: protein_coding
description:
  Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha; Belongs to the PI3/PI4-kinase family.


ensembl_gene_id: ENSLOCP00000003497
symbol: supt4h1
gene_biotype: protein_coding
description:
  Transcription elongation factor SPT4; Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II; Belongs to the SPT4 family.


ensembl_gene_id: ENSLOCP00000003573
symbol: LOC102695299
gene_biotype: protein_coding
description:
  G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.


ensembl_gene_id: ENSLOCP00000003578
symbol: med18
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 18; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.


ensembl_gene_id: ENSLOCP00000003590
symbol: eny2
gene_biotype: protein_coding
description:
  Transcription and mRNA export factor ENY2; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates histones. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. The TREX-2 complex  [...]


ensembl_gene_id: ENSLOCP00000003623
symbol: W5M5G5_LEPOC
gene_biotype: protein_coding
description:
  UDP glucuronosyltransferase 2 family, polypeptide A4; Belongs to the UDP-glycosyltransferase family.


ensembl_gene_id: ENSLOCP00000003632
symbol: gusb
gene_biotype: protein_coding
description:
  Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family.


ensembl_gene_id: ENSLOCP00000003638
symbol: NTHL1
gene_biotype: protein_coding
description:
  Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family.


ensembl_gene_id: ENSLOCP00000003669
symbol: eif3e
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.


ensembl_gene_id: ENSLOCP00000003688
symbol: lonp1
gene_biotype: protein_coding
description:
  Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family.


ensembl_gene_id: ENSLOCP00000003712
symbol: QTRT2
gene_biotype: protein_coding
description:
  Queuine tRNA-ribosyltransferase accessory subunit 2; Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine); Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.


ensembl_gene_id: ENSLOCP00000003723
symbol: prmt7
gene_biotype: protein_coding
description:
  Protein arginine N-methyltransferase; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being r [...]


ensembl_gene_id: ENSLOCP00000003749
symbol: ciapin1
gene_biotype: protein_coding
description:
  Anamorsin; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electron [...]


ensembl_gene_id: ENSLOCP00000003751
symbol: INSIG2
gene_biotype: protein_coding
description:
  Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.


ensembl_gene_id: ENSLOCP00000003760
symbol: W5M5V2_LEPOC
gene_biotype: protein_coding
description:
  Potassium voltage-gated channel, Shab-related subfamily, member 1; Belongs to the potassium channel family.


ensembl_gene_id: ENSLOCP00000003771
symbol: coq9
gene_biotype: protein_coding
description:
  Ubiquinone biosynthesis protein; Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.


ensembl_gene_id: ENSLOCP00000003776
symbol: W5M5W8_LEPOC
gene_biotype: protein_coding
description:
  Heat shock protein, alpha-crystallin-related, b15; Belongs to the small heat shock protein (HSP20) family.


ensembl_gene_id: ENSLOCP00000003785
symbol: copb1
gene_biotype: protein_coding
description:
  Coatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.


ensembl_gene_id: ENSLOCP00000003814
symbol: dhrs11
gene_biotype: protein_coding
description:
  Dehydrogenase/reductase (SDR family) member 11a; Belongs to the short-chain dehydrogenases/reductases (SDR) family.


ensembl_gene_id: ENSLOCP00000003906
symbol: eif3h
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 3 subunit H; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.


ensembl_gene_id: ENSLOCP00000003925
symbol: sbk1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase SBK1; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.


ensembl_gene_id: ENSLOCP00000003954
symbol: pole4
gene_biotype: protein_coding
description:
  Polymerase (DNA-directed), epsilon 4, accessory subunit; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.


ensembl_gene_id: ENSLOCP00000003959
symbol: LOC102691370
gene_biotype: protein_coding
description:
  Transient receptor potential cation channel, subfamily V, member 1; Belongs to the transient receptor (TC 1.A.4) family.


ensembl_gene_id: ENSLOCP00000004038
symbol: apoo
gene_biotype: protein_coding
description:
  MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.


ensembl_gene_id: ENSLOCP00000004058
symbol: ctps1
gene_biotype: protein_coding
description:
  CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.


ensembl_gene_id: ENSLOCP00000004100
symbol: rhot2
gene_biotype: protein_coding
description:
  Mitochondrial Rho GTPase; Mitochondrial GTPase involved in mitochondrial trafficking. Belongs to the mitochondrial Rho GTPase family.


ensembl_gene_id: ENSLOCP00000004111
symbol: SEC16A
gene_biotype: protein_coding
description:
  Protein transport protein sec16; Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus.


ensembl_gene_id: ENSLOCP00000004122
symbol: rhbdl1
gene_biotype: protein_coding
description:
  Rhomboid-related protein 1; May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors; Belongs to the peptidase S54 family.


ensembl_gene_id: ENSLOCP00000004156
symbol: pdha1
gene_biotype: protein_coding
description:
  Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).


ensembl_gene_id: ENSLOCP00000004167
symbol: W5M709_LEPOC
gene_biotype: protein_coding
description:
  Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.


ensembl_gene_id: ENSLOCP00000004171
symbol: W5M713_LEPOC
gene_biotype: protein_coding
description:
  Geranylgeranyl transferase type-2 subunit beta; Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C- terminal sequence -XXCC, -XCXC and -CCXX.


ensembl_gene_id: ENSLOCP00000004201
symbol: slc2a6
gene_biotype: protein_coding
description:
  Solute carrier family 2 member 6; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.


ensembl_gene_id: ENSLOCP00000004221
symbol: nmd3
gene_biotype: protein_coding
description:
  60S ribosomal export protein NMD3; Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit; Belongs to the NMD3 family.


ensembl_gene_id: ENSLOCP00000004294
symbol: pigk
gene_biotype: protein_coding
description:
  GPI-anchor transamidase; Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein. Belongs to the peptidase C13 family.


ensembl_gene_id: ENSLOCP00000004295
symbol: eif1ax
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 1A X-linked b; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.


ensembl_gene_id: ENSLOCP00000004297
symbol: W5M7D9_LEPOC
gene_biotype: protein_coding
description:
  SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family.


ensembl_gene_id: ENSLOCP00000004341
symbol: st8sia3
gene_biotype: protein_coding
description:
  ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3; Belongs to the glycosyltransferase 29 family.


ensembl_gene_id: ENSLOCP00000004345
symbol: st3gal1
gene_biotype: protein_coding
description:
  ST3 beta-galactoside alpha-2,3-sialyltransferase 1, like; Belongs to the glycosyltransferase 29 family.


ensembl_gene_id: ENSLOCP00000004366
symbol: agpat2
gene_biotype: protein_coding
description:
  1-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.


ensembl_gene_id: ENSLOCP00000004385
symbol: W5M7M7_LEPOC
gene_biotype: protein_coding
description:
  Probable ribosome biogenesis protein; Probable pre-rRNA processing protein involved in ribosome biogenesis.


ensembl_gene_id: ENSLOCP00000004443
symbol: W5M7T5_LEPOC
gene_biotype: protein_coding
description:
  Solute carrier family 2 member 1b; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.


ensembl_gene_id: ENSLOCP00000004455
symbol: fa2h
gene_biotype: protein_coding
description:
  Fatty acid 2-hydroxylase; Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...]


ensembl_gene_id: ENSLOCP00000004475
symbol: med13
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 13; Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.


ensembl_gene_id: ENSLOCP00000004511
symbol: GFM1
gene_biotype: protein_coding
description:
  Elongation factor G, mitochondrial; Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mito [...]


ensembl_gene_id: ENSLOCP00000004512
symbol: pigv
gene_biotype: protein_coding
description:
  GPI mannosyltransferase 2; Mannosyltransferase involved in glycosylphosphatidylinositol- anchor biosynthesis.


ensembl_gene_id: ENSLOCP00000004513
symbol: ampd3
gene_biotype: protein_coding
description:
  AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.


ensembl_gene_id: ENSLOCP00000004515
symbol: LOC102695755
gene_biotype: protein_coding
description:
  Septin 15; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.


ensembl_gene_id: ENSLOCP00000004528
symbol: LOC102694050
gene_biotype: protein_coding
description:
  Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.


ensembl_gene_id: ENSLOCP00000004554
symbol: LOC102691967
gene_biotype: protein_coding
description:
  Solute carrier family 2 member 11b; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.


ensembl_gene_id: ENSLOCP00000004555
symbol: kcnb2
gene_biotype: protein_coding
description:
  Potassium voltage-gated channel, Shab-related subfamily, member 2; Belongs to the potassium channel family.


ensembl_gene_id: ENSLOCP00000004565
symbol: gpn2
gene_biotype: protein_coding
description:
  GPN-loop GTPase 2; Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family.


ensembl_gene_id: ENSLOCP00000004568
symbol: W5M860_LEPOC
gene_biotype: protein_coding
description:
  AP-1 complex subunit mu-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.


ensembl_gene_id: ENSLOCP00000004576
symbol: rps6kb1
gene_biotype: protein_coding
description:
  Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.


ensembl_gene_id: ENSLOCP00000004596
symbol: kcnk9
gene_biotype: protein_coding
description:
  Potassium channel, subfamily K, member 9; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.


ensembl_gene_id: ENSLOCP00000004625
symbol: LOC102698397
gene_biotype: protein_coding
description:
  Gamma-aminobutyric acid (GABA) A receptor, rho 3b; Belongs to the ligand-gated ion channel (TC 1.A.9) family.


ensembl_gene_id: ENSLOCP00000004635
symbol: LOC102696292
gene_biotype: protein_coding
description:
  Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.


ensembl_gene_id: ENSLOCP00000004650
symbol: trpa1
gene_biotype: protein_coding
description:
  Transient receptor potential cation channel, subfamily A, member 1a; Belongs to the transient receptor (TC 1.A.4) family.


ensembl_gene_id: ENSLOCP00000004651
symbol: METTL1
gene_biotype: protein_coding
description:
  tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.


ensembl_gene_id: ENSLOCP00000004656
symbol: wdr4
gene_biotype: protein_coding
description:
  tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4; Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit. Belongs to the WD repeat TRM82 family.


ensembl_gene_id: ENSLOCP00000004704
symbol: W5M8J6_LEPOC
gene_biotype: protein_coding
description:
  Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.


ensembl_gene_id: ENSLOCP00000004713
symbol: pes1
gene_biotype: protein_coding
description:
  Pescadillo homolog; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.


ensembl_gene_id: ENSLOCP00000004718
symbol: elovl1
gene_biotype: protein_coding
description:
  Elongation of very long chain fatty acids protein 1; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that  [...]


ensembl_gene_id: ENSLOCP00000004785
symbol: pole
gene_biotype: protein_coding
description:
  DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.


ensembl_gene_id: ENSLOCP00000004791
symbol: serpine2
gene_biotype: protein_coding
description:
  Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2; Belongs to the serpin family.


ensembl_gene_id: ENSLOCP00000004808
symbol: atp5mg
gene_biotype: protein_coding
description:
  ATP synthase subunit; Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proto [...]


ensembl_gene_id: ENSLOCP00000004816
symbol: gcsh
gene_biotype: protein_coding
description:
  Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.


ensembl_gene_id: ENSLOCP00000004817
symbol: cope
gene_biotype: protein_coding
description:
  Coatomer subunit epsilon; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Belongs to the COPE family.


ensembl_gene_id: ENSLOCP00000004842
symbol: GATC
gene_biotype: protein_coding
description:
  Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Belongs to the GatC family.


ensembl_gene_id: ENSLOCP00000004848
symbol: W5M8Y9_LEPOC
gene_biotype: protein_coding
description:
  SURF1-like protein; Probably involved in the biogenesis of the COX complex. Belongs to the SURF1 family.


ensembl_gene_id: ENSLOCP00000004869
symbol: nsun4
gene_biotype: protein_coding
description:
  NOP2/Sun RNA methyltransferase 4; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.


ensembl_gene_id: ENSLOCP00000004873
symbol: ncln
gene_biotype: protein_coding
description:
  Nicalin; May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning.


ensembl_gene_id: ENSLOCP00000004893
symbol: KMT2A
gene_biotype: protein_coding
description:
  Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily.


ensembl_gene_id: ENSLOCP00000004905
symbol: W5M946_LEPOC
gene_biotype: protein_coding
description:
  Cytochrome b-c1 complex subunit 6; This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1. Belongs to the UQCRH/QCR6 family.


ensembl_gene_id: ENSLOCP00000004983
symbol: W5M9C4_LEPOC
gene_biotype: protein_coding
description:
  Protein SDA1; Required for 60S pre-ribosomal subunits export to the cytoplasm; Belongs to the SDA1 family.


ensembl_gene_id: ENSLOCP00000005006
symbol: cxcl12
gene_biotype: protein_coding
description:
  Chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1); Belongs to the intercrine alpha (chemokine CxC) family.


ensembl_gene_id: ENSLOCP00000005016
symbol: pif1
gene_biotype: protein_coding
description:
  ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability.


ensembl_gene_id: ENSLOCP00000005044
symbol: eif3b
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 3 subunit B; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome; Belongs to the eIF-3 subunit B family.


ensembl_gene_id: ENSLOCP00000005059
symbol: idh1
gene_biotype: protein_coding
description:
  Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family.


ensembl_gene_id: ENSLOCP00000005078
symbol: ak6
gene_biotype: protein_coding
description:
  Adenylate kinase isoenzyme 6; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation; Belongs to the adenylate kinase family. AK6 subfamily.


ensembl_gene_id: ENSLOCP00000005101
symbol: echs1
gene_biotype: protein_coding
description:
  Enoyl CoA hydratase, short chain, 1, mitochondrial; Belongs to the enoyl-CoA hydratase/isomerase family.


ensembl_gene_id: ENSLOCP00000005105
symbol: LOC102683282
gene_biotype: protein_coding
description:
  NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.


ensembl_gene_id: ENSLOCP00000005107
symbol: trpv4
gene_biotype: protein_coding
description:
  Transient receptor potential cation channel, subfamily V, member 4; Belongs to the transient receptor (TC 1.A.4) family.


ensembl_gene_id: ENSLOCP00000005152
symbol: FLT3
gene_biotype: protein_coding
description:
  Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.


ensembl_gene_id: ENSLOCP00000005162
symbol: mvk
gene_biotype: protein_coding
description:
  Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.


ensembl_gene_id: ENSLOCP00000005186
symbol: PAN2
gene_biotype: protein_coding
description:
  PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent  [...]


ensembl_gene_id: ENSLOCP00000005189
symbol: myh7b
gene_biotype: protein_coding
description:
  Myosin, heavy chain 7B, cardiac muscle, beta a; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.


ensembl_gene_id: ENSLOCP00000005190
symbol: pan3
gene_biotype: protein_coding
description:
  PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...]


ensembl_gene_id: ENSLOCP00000005195
symbol: hyi
gene_biotype: protein_coding
description:
  Putative hydroxypyruvate isomerase; Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde); Belongs to the hyi family.


ensembl_gene_id: ENSLOCP00000005201
symbol: W5M9Z2_LEPOC
gene_biotype: protein_coding
description:
  Retinol binding protein 2a, cellular; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.


ensembl_gene_id: ENSLOCP00000005208
symbol: W5M9Z9_LEPOC
gene_biotype: protein_coding
description:
  Gamma-tubulin complex component; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome; Belongs to the TUBGCP family.


ensembl_gene_id: ENSLOCP00000005215
symbol: zmpste24
gene_biotype: protein_coding
description:
  CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family.


ensembl_gene_id: ENSLOCP00000005239
symbol: flt1
gene_biotype: protein_coding
description:
  Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.


ensembl_gene_id: ENSLOCP00000005261
symbol: med8
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 8; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.


ensembl_gene_id: ENSLOCP00000005286
symbol: pik3cb
gene_biotype: protein_coding
description:
  Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; Belongs to the PI3/PI4-kinase family.


ensembl_gene_id: ENSLOCP00000005293
symbol: mettl16
gene_biotype: protein_coding
description:
  U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase; RNA N6-methyltransferase that methylates adenosine residues of a subset of RNAs and plays a key role in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6- methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure. In presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifical [...]


ensembl_gene_id: ENSLOCP00000005309
symbol: W5MAA0_LEPOC
gene_biotype: protein_coding
description:
  Mitochondrial import inner membrane translocase subunit TIM44; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the Tim44 family.


ensembl_gene_id: ENSLOCP00000005311
symbol: PAFAH1B1
gene_biotype: protein_coding
description:
  Lissencephaly-1 homolog; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration; Belongs to the WD repeat LIS1/nudF family.


ensembl_gene_id: ENSLOCP00000005334
symbol: dhodh
gene_biotype: protein_coding
description:
  Dihydroorotate dehydrogenase (quinone), mitochondrial; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.


ensembl_gene_id: ENSLOCP00000005339
symbol: cluh
gene_biotype: protein_coding
description:
  Clustered mitochondria protein homolog; mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria. Specifically binds mRNAs of nuclear- encoded mitochondrial proteins in the cytoplasm and regulates transport or translation of these transcripts close to mitochondria, playing a role in mitochondrial biogenesis; Belongs to the CLU family.


ensembl_gene_id: ENSLOCP00000005349
symbol: mrto4
gene_biotype: protein_coding
description:
  Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.


ensembl_gene_id: ENSLOCP00000005362
symbol: ung
gene_biotype: protein_coding
description:
  Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.


ensembl_gene_id: ENSLOCP00000005363
symbol: kdm1a
gene_biotype: protein_coding
description:
  Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.


ensembl_gene_id: ENSLOCP00000005393
symbol: ap3m1
gene_biotype: protein_coding
description:
  AP-3 complex subunit mu-1; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes; Belongs to the adaptor complexes medium subunit family.


ensembl_gene_id: ENSLOCP00000005400
symbol: W5MAJ1_LEPOC
gene_biotype: protein_coding
description:
  Chemokine (C-X-C motif) receptor 3, tandem duplicate 1; Belongs to the G-protein coupled receptor 1 family.


ensembl_gene_id: ENSLOCP00000005411
symbol: eif3m
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 3 subunit M; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.


ensembl_gene_id: ENSLOCP00000005423
symbol: LOC102694828
gene_biotype: protein_coding
description:
  Actin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.


ensembl_gene_id: ENSLOCP00000005443
symbol: W5MAN4_LEPOC
gene_biotype: protein_coding
description:
  Uncharacterized protein; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.


ensembl_gene_id: ENSLOCP00000005460
symbol: LOC107077303
gene_biotype: protein_coding
description:
  Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.


ensembl_gene_id: ENSLOCP00000005477
symbol: LOC102682810
gene_biotype: protein_coding
description:
  ATPase Na+/K+ transporting subunit alpha 3; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.


ensembl_gene_id: ENSLOCP00000005503
symbol: W5MAU4_LEPOC
gene_biotype: protein_coding
description:
  5-hydroxytryptamine (serotonin) receptor 3B; Belongs to the ligand-gated ion channel (TC 1.A.9) family.


ensembl_gene_id: ENSLOCP00000005535
symbol: LOC102684098
gene_biotype: protein_coding
description:
  5-hydroxytryptamine (serotonin) receptor 3A; Belongs to the ligand-gated ion channel (TC 1.A.9) family.


ensembl_gene_id: ENSLOCP00000005549
symbol: cdh15
gene_biotype: protein_coding
description:
  Cadherin 15, type 1, M-cadherin (myotubule); Cadherins are calcium-dependent cell adhesion proteins.


ensembl_gene_id: ENSLOCP00000005561
symbol: gosr1
gene_biotype: protein_coding
description:
  Golgi SNAP receptor complex member 1; Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor.


ensembl_gene_id: ENSLOCP00000005577
symbol: W5MB18_LEPOC
gene_biotype: protein_coding
description:
  Glutamate receptor, ionotropic, kainate 5; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.


ensembl_gene_id: ENSLOCP00000005617
symbol: psmd1
gene_biotype: protein_coding
description:
  26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family.


ensembl_gene_id: ENSLOCP00000005620
symbol: iscu
gene_biotype: protein_coding
description:
  Iron-sulfur cluster assembly enzyme b; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.


ensembl_gene_id: ENSLOCP00000005682
symbol: W5MBC3_LEPOC
gene_biotype: protein_coding
description:
  Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.


ensembl_gene_id: ENSLOCP00000005702
symbol: W5MBE3_LEPOC
gene_biotype: protein_coding
description:
  Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.


ensembl_gene_id: ENSLOCP00000005770
symbol: dis3l2
gene_biotype: protein_coding
description:
  DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase. Essential for correct mitosis, and negatively regulates cell proliferation. Belongs to the RNR ribonuclease family. DIS3L2 subfamily.


ensembl_gene_id: ENSLOCP00000005805
symbol: draxin
gene_biotype: protein_coding
description:
  Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord; Belongs to the draxin family.


ensembl_gene_id: ENSLOCP00000005813
symbol: CTU2
gene_biotype: protein_coding
description:
  Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with CTU1/ATPBD3 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.


ensembl_gene_id: ENSLOCP00000005843
symbol: W5MBT4_LEPOC
gene_biotype: protein_coding
description:
  Integrin, alpha 5 (fibronectin receptor, alpha polypeptide); Belongs to the integrin alpha chain family.


ensembl_gene_id: ENSLOCP00000005920
symbol: prmt3
gene_biotype: protein_coding
description:
  Protein arginine methyltransferase 3; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.


ensembl_gene_id: ENSLOCP00000005926
symbol: LOC102694797
gene_biotype: protein_coding
description:
  Retinol dehydrogenase 5 (11-cis/9-cis); Belongs to the short-chain dehydrogenases/reductases (SDR) family.


ensembl_gene_id: ENSLOCP00000005959
symbol: polr3a
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.


ensembl_gene_id: ENSLOCP00000005966
symbol: atp13a3
gene_biotype: protein_coding
description:
  Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.


ensembl_gene_id: ENSLOCP00000005967
symbol: ncapd3
gene_biotype: protein_coding
description:
  Condensin-2 complex subunit D3; Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis.


ensembl_gene_id: ENSLOCP00000006011
symbol: pigp
gene_biotype: protein_coding
description:
  Phosphatidylinositol N-acetylglucosaminyltransferase subunit P; Part of the complex catalyzing the transfer of N- acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.


ensembl_gene_id: ENSLOCP00000006033
symbol: opa1
gene_biotype: protein_coding
description:
  OPA1 mitochondrial dynamin like GTPase; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.


ensembl_gene_id: ENSLOCP00000006048
symbol: nae1
gene_biotype: protein_coding
description:
  NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.


ensembl_gene_id: ENSLOCP00000006059
symbol: nadsyn1
gene_biotype: protein_coding
description:
  Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family.


ensembl_gene_id: ENSLOCP00000006118
symbol: riox2
gene_biotype: protein_coding
description:
  Bifunctional lysine-specific demethylase and histidyl-hydroxylase; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase.


ensembl_gene_id: ENSLOCP00000006129
symbol: MOCOS
gene_biotype: protein_coding
description:
  Molybdenum cofactor sulfurase; Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.


ensembl_gene_id: ENSLOCP00000006202
symbol: tp63
gene_biotype: protein_coding
description:
  Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.


ensembl_gene_id: ENSLOCP00000006252
symbol: W5MCZ3_LEPOC
gene_biotype: protein_coding
description:
  Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.


ensembl_gene_id: ENSLOCP00000006279
symbol: tmem97
gene_biotype: protein_coding
description:
  Transmembrane protein 97; Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cells. Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation. May play a role as a regulator of cellular cholesterol homeostasis. May function as sterol isomerase. May alter the activity of some cytochrome P450 proteins.


ensembl_gene_id: ENSLOCP00000006280
symbol: W5MD21_LEPOC
gene_biotype: protein_coding
description:
  Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.


ensembl_gene_id: ENSLOCP00000006282
symbol: hs6st3
gene_biotype: protein_coding
description:
  Heparan-sulfate 6-O-sulfotransferase; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.


ensembl_gene_id: ENSLOCP00000006293
symbol: polrmt
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the phage and mitochondrial RNA polymerase family.


ensembl_gene_id: ENSLOCP00000006294
symbol: lsm2
gene_biotype: protein_coding
description:
  U6 snRNA-associated Sm-like protein LSm2; Binds specifically to the 3'-terminal U-tract of U6 snRNA.


ensembl_gene_id: ENSLOCP00000006301
symbol: cdh11
gene_biotype: protein_coding
description:
  Cadherin 11, type 2, OB-cadherin (osteoblast); Cadherins are calcium-dependent cell adhesion proteins.


ensembl_gene_id: ENSLOCP00000006343
symbol: tp73
gene_biotype: protein_coding
description:
  Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.


ensembl_gene_id: ENSLOCP00000006349
symbol: W5MD90_LEPOC
gene_biotype: protein_coding
description:
  GPI inositol-deacylase; Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI- anchored proteins from the endoplasmic reticulum to the Golgi.


ensembl_gene_id: ENSLOCP00000006364
symbol: tpst1
gene_biotype: protein_coding
description:
  Protein-tyrosine sulfotransferase; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate; Belongs to the protein sulfotransferase family.


ensembl_gene_id: ENSLOCP00000006380
symbol: fabp3
gene_biotype: protein_coding
description:
  Fatty acid binding protein 3, muscle and heart; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.


ensembl_gene_id: ENSLOCP00000006404
symbol: ckmt2
gene_biotype: protein_coding
description:
  Creatine kinase, mitochondrial 2b (sarcomeric); Belongs to the ATP:guanido phosphotransferase family.


ensembl_gene_id: ENSLOCP00000006408
symbol: vps16
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS16 family.


ensembl_gene_id: ENSLOCP00000006421
symbol: phkb
gene_biotype: protein_coding
description:
  Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I.


ensembl_gene_id: ENSLOCP00000006425
symbol: W5MDG6_LEPOC
gene_biotype: protein_coding
description:
  Stearoyl-CoA desaturase b; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.


ensembl_gene_id: ENSLOCP00000006429
symbol: W5MDH0_LEPOC
gene_biotype: protein_coding
description:
  Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum.


ensembl_gene_id: ENSLOCP00000006446
symbol: panx3
gene_biotype: protein_coding
description:
  Pannexin; Structural component of the gap junctions and the hemichannels; Belongs to the pannexin family.


ensembl_gene_id: ENSLOCP00000006470
symbol: gfm2
gene_biotype: protein_coding
description:
  Ribosome-releasing factor 2, mitochondrial; Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.


ensembl_gene_id: ENSLOCP00000006481
symbol: sdr16c5
gene_biotype: protein_coding
description:
  Short chain dehydrogenase/reductase family 16C, member 5b; Belongs to the short-chain dehydrogenases/reductases (SDR) family.


ensembl_gene_id: ENSLOCP00000006488
symbol: lcmt1
gene_biotype: protein_coding
description:
  Leucine carboxyl methyltransferase 1; Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha- leucine ester residues; Belongs to the methyltransferase superfamily. LCMT family.


ensembl_gene_id: ENSLOCP00000006536
symbol: ndufb8
gene_biotype: protein_coding
description:
  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.


ensembl_gene_id: ENSLOCP00000006545
symbol: prdm12
gene_biotype: protein_coding
description:
  PR domain zinc finger protein 12; Involved in the positive regulation of histone H3-K9 dimethylation; Belongs to the class V-like SAM-binding methyltransferase superfamily.


ensembl_gene_id: ENSLOCP00000006547
symbol: micos13
gene_biotype: protein_coding
description:
  MICOS complex subunit MIC13; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.


ensembl_gene_id: ENSLOCP00000006568
symbol: W5MDV9_LEPOC
gene_biotype: protein_coding
description:
  Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.


ensembl_gene_id: ENSLOCP00000006651
symbol: gtf2f2
gene_biotype: protein_coding
description:
  General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity.


ensembl_gene_id: ENSLOCP00000006683
symbol: chrm4
gene_biotype: protein_coding
description:
  Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.


ensembl_gene_id: ENSLOCP00000006710
symbol: trpc6
gene_biotype: protein_coding
description:
  Transient receptor potential cation channel, subfamily C, member 6a; Belongs to the transient receptor (TC 1.A.4) family.


ensembl_gene_id: ENSLOCP00000006758
symbol: pop4
gene_biotype: protein_coding
description:
  Ribonuclease P protein subunit p29; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.


ensembl_gene_id: ENSLOCP00000006786
symbol: AMHR2
gene_biotype: protein_coding
description:
  Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.


ensembl_gene_id: ENSLOCP00000006792
symbol: LOC102683753
gene_biotype: protein_coding
description:
  Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.


ensembl_gene_id: ENSLOCP00000006808
symbol: rgr
gene_biotype: protein_coding
description:
  Retinal G protein coupled receptor a; Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.


ensembl_gene_id: ENSLOCP00000006834
symbol: LOC102682940
gene_biotype: protein_coding
description:
  DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.


ensembl_gene_id: ENSLOCP00000006850
symbol: crhbp
gene_biotype: protein_coding
description:
  Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family.


ensembl_gene_id: ENSLOCP00000006885
symbol: LOC102683145
gene_biotype: protein_coding
description:
  DNA (cytosine-5-)-methyltransferase 3 beta, duplicate b.1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.


ensembl_gene_id: ENSLOCP00000006888
symbol: vps11
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family.


ensembl_gene_id: ENSLOCP00000006913
symbol: tarbp2
gene_biotype: protein_coding
description:
  RISC-loading complex subunit TARBP2; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from [...]


ensembl_gene_id: ENSLOCP00000006931
symbol: rhbdl2
gene_biotype: protein_coding
description:
  Rhomboid-related protein 2; Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors; Belongs to the peptidase S54 family.


ensembl_gene_id: ENSLOCP00000006945
symbol: W5MEY6_LEPOC
gene_biotype: protein_coding
description:
  Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.


ensembl_gene_id: ENSLOCP00000006950
symbol: atp6v1h
gene_biotype: protein_coding
description:
  V-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system.


ensembl_gene_id: ENSLOCP00000006960
symbol: supt6h
gene_biotype: protein_coding
description:
  Transcription elongation factor spt6; Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). Belongs to the SPT6 family.


ensembl_gene_id: ENSLOCP00000007000
symbol: utp11
gene_biotype: protein_coding
description:
  U3 small nucleolar RNA-associated protein 11; Involved in nucleolar processing of pre-18S ribosomal RNA.


ensembl_gene_id: ENSLOCP00000007003
symbol: W5MF44_LEPOC
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 4E family member 2; Belongs to the eukaryotic initiation factor 4E family.


ensembl_gene_id: ENSLOCP00000007022
symbol: kif5a
gene_biotype: protein_coding
description:
  Kinesin family member 5A, a; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.


ensembl_gene_id: ENSLOCP00000007025
symbol: LOC102685347
gene_biotype: protein_coding
description:
  Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family.


ensembl_gene_id: ENSLOCP00000007081
symbol: eif2b1
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 2B, subunit 1 alpha; Belongs to the eIF-2B alpha/beta/delta subunits family.


ensembl_gene_id: ENSLOCP00000007139
symbol: W5MFI0_LEPOC
gene_biotype: protein_coding
description:
  Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.


ensembl_gene_id: ENSLOCP00000007155
symbol: alg3
gene_biotype: protein_coding
description:
  Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase; Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-Dol.


ensembl_gene_id: ENSLOCP00000007160
symbol: gnl2
gene_biotype: protein_coding
description:
  Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.


ensembl_gene_id: ENSLOCP00000007173
symbol: kcnv1
gene_biotype: protein_coding
description:
  Potassium voltage-gated channel modifier subfamily V member 1; Belongs to the potassium channel family.


ensembl_gene_id: ENSLOCP00000007257
symbol: ppp1r3c
gene_biotype: protein_coding
description:
  Protein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown.


ensembl_gene_id: ENSLOCP00000007306
symbol: aldh9a1
gene_biotype: protein_coding
description:
  Aldehyde dehydrogenase 9 family, member A1a, tandem duplicate 1; Belongs to the aldehyde dehydrogenase family.


ensembl_gene_id: ENSLOCP00000007307
symbol: sdhd
gene_biotype: protein_coding
description:
  Succinate dehydrogenase [ubiquinone] cytochrome b small subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the CybS family.


ensembl_gene_id: ENSLOCP00000007329
symbol: tmco1
gene_biotype: protein_coding
description:
  Calcium load-activated calcium channel; Calcium-selective channel required to prevent calcium stores from overfilling.


ensembl_gene_id: ENSLOCP00000007333
symbol: W5MG24_LEPOC
gene_biotype: protein_coding
description:
  Methyl-CpG binding domain protein 3b; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.


ensembl_gene_id: ENSLOCP00000007336
symbol: W5MG27_LEPOC
gene_biotype: protein_coding
description:
  Protein phosphatase methylesterase 1; Demethylates proteins that have been reversibly carboxymethylated.


ensembl_gene_id: ENSLOCP00000007340
symbol: W5MG31_LEPOC
gene_biotype: protein_coding
description:
  Coactivator-associated arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.


ensembl_gene_id: ENSLOCP00000007345
symbol: gabrd
gene_biotype: protein_coding
description:
  Gamma-aminobutyric acid (GABA) A receptor, delta; Belongs to the ligand-gated ion channel (TC 1.A.9) family.


ensembl_gene_id: ENSLOCP00000007411
symbol: kifc3
gene_biotype: protein_coding
description:
  Kinesin family member C3; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.


ensembl_gene_id: ENSLOCP00000007423
symbol: pten
gene_biotype: protein_coding
description:
  Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.


ensembl_gene_id: ENSLOCP00000007424
symbol: nubp1
gene_biotype: protein_coding
description:
  Cytosolic Fe-S cluster assembly factor NUBP1; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.


ensembl_gene_id: ENSLOCP00000007437
symbol: dpm2
gene_biotype: protein_coding
description:
  Dolichol phosphate-mannose biosynthesis regulatory protein; Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization. Belongs to the DPM2 family.


ensembl_gene_id: ENSLOCP00000007447
symbol: katnb1
gene_biotype: protein_coding
description:
  Katanin p80 WD40 repeat-containing subunit B1; Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.


ensembl_gene_id: ENSLOCP00000007456
symbol: slc47a1
gene_biotype: protein_coding
description:
  Multidrug and toxin extrusion protein; Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.


ensembl_gene_id: ENSLOCP00000007531
symbol: RAN
gene_biotype: protein_coding
description:
  GTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family.


ensembl_gene_id: ENSLOCP00000007589
symbol: orc1
gene_biotype: protein_coding
description:
  Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.


ensembl_gene_id: ENSLOCP00000007614
symbol: setd6
gene_biotype: protein_coding
description:
  N-lysine methyltransferase SETD6; Protein-lysine N-methyltransferase. Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily.


ensembl_gene_id: ENSLOCP00000007618
symbol: septin2
gene_biotype: protein_coding
description:
  Septin 2; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.


ensembl_gene_id: ENSLOCP00000007656
symbol: W5MGZ7_LEPOC
gene_biotype: protein_coding
description:
  Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family.


ensembl_gene_id: ENSLOCP00000007694
symbol: MX1
gene_biotype: protein_coding
description:
  MX dynamin like GTPase 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.


ensembl_gene_id: ENSLOCP00000007722
symbol: LOC102695738
gene_biotype: protein_coding
description:
  Adaptor related protein complex 1 subunit mu 3; Belongs to the adaptor complexes medium subunit family.


ensembl_gene_id: ENSLOCP00000007730
symbol: W5MH71_LEPOC
gene_biotype: protein_coding
description:
  RNA polymerase III subunit C3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.


ensembl_gene_id: ENSLOCP00000007742
symbol: rpa1
gene_biotype: protein_coding
description:
  Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.


ensembl_gene_id: ENSLOCP00000007757
symbol: LOC102683352
gene_biotype: protein_coding
description:
  Cellular retinoic acid binding protein 2, b; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.


ensembl_gene_id: ENSLOCP00000007766
symbol: cdc34
gene_biotype: protein_coding
description:
  Cell division cycle 34 homolog (S. cerevisiae) a; Belongs to the ubiquitin-conjugating enzyme family.


ensembl_gene_id: ENSLOCP00000007777
symbol: W5MHB8_LEPOC
gene_biotype: protein_coding
description:
  2-(3-amino-3-carboxypropyl)histidine synthase subunit 1; Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.


ensembl_gene_id: ENSLOCP00000007811
symbol: W5MHF2_LEPOC
gene_biotype: protein_coding
description:
  Hemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation.


ensembl_gene_id: ENSLOCP00000007816
symbol: med15
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.


ensembl_gene_id: ENSLOCP00000007841
symbol: ube2e3
gene_biotype: protein_coding
description:
  Ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast); Belongs to the ubiquitin-conjugating enzyme family.


ensembl_gene_id: ENSLOCP00000007843
symbol: atg4b
gene_biotype: protein_coding
description:
  Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family.


ensembl_gene_id: ENSLOCP00000007884
symbol: LOC102682268
gene_biotype: protein_coding
description:
  Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.


ensembl_gene_id: ENSLOCP00000007895
symbol: copz1
gene_biotype: protein_coding
description:
  Coatomer subunit zeta; The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.


ensembl_gene_id: ENSLOCP00000007931
symbol: pmm2
gene_biotype: protein_coding
description:
  Phosphomannomutase; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions.


ensembl_gene_id: ENSLOCP00000007967
symbol: kif1a
gene_biotype: protein_coding
description:
  Kinesin family member 1Aa; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.


ensembl_gene_id: ENSLOCP00000007981
symbol: abat
gene_biotype: protein_coding
description:
  4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.


ensembl_gene_id: ENSLOCP00000007985
symbol: TSFM
gene_biotype: protein_coding
description:
  Elongation factor Ts, mitochondrial; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family.


ensembl_gene_id: ENSLOCP00000008013
symbol: dusp19
gene_biotype: protein_coding
description:
  Dual specificity phosphatase 19a; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.


ensembl_gene_id: ENSLOCP00000008021
symbol: LOC102693174
gene_biotype: protein_coding
description:
  Repressor of RNA polymerase III transcription MAF1; Element of the TORC1 signaling pathway that acts as a mediator of diverse signals and that represses RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA. Belongs to the MAF1 family.


ensembl_gene_id: ENSLOCP00000008043
symbol: pgd
gene_biotype: protein_coding
description:
  6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.


ensembl_gene_id: ENSLOCP00000008060
symbol: trappc5
gene_biotype: protein_coding
description:
  Trafficking protein particle complex subunit 5; May play a role in vesicular transport from endoplasmic reticulum to Golgi.


ensembl_gene_id: ENSLOCP00000008065
symbol: rbfox1
gene_biotype: protein_coding
description:
  RNA binding protein fox-1 homolog 1; RNA-binding protein that regulates alternative splicing events.


ensembl_gene_id: ENSLOCP00000008073
symbol: smarcb1
gene_biotype: protein_coding
description:
  SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Belongs to the SNF5 family.


ensembl_gene_id: ENSLOCP00000008098
symbol: kcnc1
gene_biotype: protein_coding
description:
  Potassium voltage-gated channel, Shaw-related subfamily, member 1b; Belongs to the potassium channel family.


ensembl_gene_id: ENSLOCP00000008104
symbol: ror1
gene_biotype: protein_coding
description:
  Receptor tyrosine kinase-like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.


ensembl_gene_id: ENSLOCP00000008115
symbol: W5MIA6_LEPOC
gene_biotype: protein_coding
description:
  Kinesin family member 1B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.


ensembl_gene_id: ENSLOCP00000008118
symbol: nup35
gene_biotype: protein_coding
description:
  Nucleoporin NUP53; Functions as a component of the nuclear pore complex (NPC). Belongs to the Nup35 family.


ensembl_gene_id: ENSLOCP00000008119
symbol: slc2a11
gene_biotype: protein_coding
description:
  Solute carrier family 2 member 11a; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.


ensembl_gene_id: ENSLOCP00000008127
symbol: septin12
gene_biotype: protein_coding
description:
  Septin 12; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.


ensembl_gene_id: ENSLOCP00000008130
symbol: sema6b
gene_biotype: protein_coding
description:
  Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6Ba; Belongs to the semaphorin family.


ensembl_gene_id: ENSLOCP00000008140
symbol: LOC102691905
gene_biotype: protein_coding
description:
  MFS domain-containing protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.


ensembl_gene_id: ENSLOCP00000008150
symbol: W5MIE1_LEPOC
gene_biotype: protein_coding
description:
  Si:ch73-74h11.1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.


ensembl_gene_id: ENSLOCP00000008171
symbol: LOC102692106
gene_biotype: protein_coding
description:
  Solute carrier family 2 member 11, like; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.


ensembl_gene_id: ENSLOCP00000008185
symbol: W5MIH6_LEPOC
gene_biotype: protein_coding
description:
  Retinol binding protein 7b, cellular; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.


ensembl_gene_id: ENSLOCP00000008195
symbol: scn8a
gene_biotype: protein_coding
description:
  Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.


ensembl_gene_id: ENSLOCP00000008214
symbol: LOC102688792
gene_biotype: protein_coding
description:
  Uncharacterized protein; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.


ensembl_gene_id: ENSLOCP00000008225
symbol: W5MIL6_LEPOC
gene_biotype: protein_coding
description:
  Hermansky-Pudlak syndrome 5 protein homolog; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.


ensembl_gene_id: ENSLOCP00000008262
symbol: W5MIQ3_LEPOC
gene_biotype: protein_coding
description:
  Potassium voltage-gated channel, Shaw-related subfamily, member 3b; Belongs to the potassium channel family.


ensembl_gene_id: ENSLOCP00000008289
symbol: LOC102688988
gene_biotype: protein_coding
description:
  Desmocollin 2 like; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.


ensembl_gene_id: ENSLOCP00000008326
symbol: W5MIW7_LEPOC
gene_biotype: protein_coding
description:
  Cyclic AMP-dependent transcription factor ATF-7; Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters.


ensembl_gene_id: ENSLOCP00000008346
symbol: LOC102685547
gene_biotype: protein_coding
description:
  Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.


ensembl_gene_id: ENSLOCP00000008347
symbol: itga2
gene_biotype: protein_coding
description:
  Integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor), tandem duplicate 2; Belongs to the integrin alpha chain family.


ensembl_gene_id: ENSLOCP00000008359
symbol: top2b
gene_biotype: protein_coding
description:
  DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.


ensembl_gene_id: ENSLOCP00000008364
symbol: LOC102686397
gene_biotype: protein_coding
description:
  Molybdopterin synthase catalytic subunit; Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group; Belongs to the MoaE family. MOCS2B subfamily.


ensembl_gene_id: ENSLOCP00000008374
symbol: W5MJ15_LEPOC
gene_biotype: protein_coding
description:
  Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta; Belongs to the PI3/PI4-kinase family.


ensembl_gene_id: ENSLOCP00000008376
symbol: p2rx7
gene_biotype: protein_coding
description:
  P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family.


ensembl_gene_id: ENSLOCP00000008382
symbol: LOC102686597
gene_biotype: protein_coding
description:
  Molybdopterin synthase sulfur carrier subunit; Acts as a sulfur carrier required for molybdopterin biosynthesis. Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group. In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. After interaction with MOCS2B, the sulfur is then transferred to precursor Z to form molybdopterin; Belongs to the MoaD family. MOCS2A subfamily.


ensembl_gene_id: ENSLOCP00000008414
symbol: W5MJ55_LEPOC
gene_biotype: protein_coding
description:
  3-oxoacyl-[acyl-carrier-protein] synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.


ensembl_gene_id: ENSLOCP00000008419
symbol: agps
gene_biotype: protein_coding
description:
  Alkylglycerone-phosphate synthase; Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids; Belongs to the FAD-binding oxidoreductase/transferase type 4 family.


ensembl_gene_id: ENSLOCP00000008427
symbol: W5MJ68_LEPOC
gene_biotype: protein_coding
description:
  AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]


ensembl_gene_id: ENSLOCP00000008448
symbol: W5MJ89_LEPOC
gene_biotype: protein_coding
description:
  Tyrosine kinase, non-receptor, 2b; Belongs to the protein kinase superfamily. Tyr protein kinase family.


ensembl_gene_id: ENSLOCP00000008468
symbol: ncapd2
gene_biotype: protein_coding
description:
  Condensin complex subunit 1; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.


ensembl_gene_id: ENSLOCP00000008473
symbol: septin7
gene_biotype: protein_coding
description:
  Septin 7b; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.


ensembl_gene_id: ENSLOCP00000008543
symbol: adora2a
gene_biotype: protein_coding
description:
  Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.


ensembl_gene_id: ENSLOCP00000008547
symbol: nop2
gene_biotype: protein_coding
description:
  NOP2 nucleolar protein homolog (yeast); Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.


ensembl_gene_id: ENSLOCP00000008565
symbol: W5MJK6_LEPOC
gene_biotype: protein_coding
description:
  SMG1 nonsense mediated mRNA decay associated PI3K related kinase; Belongs to the PI3/PI4-kinase family.


ensembl_gene_id: ENSLOCP00000008570
symbol: cds1
gene_biotype: protein_coding
description:
  Phosphatidate cytidylyltransferase; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin.


ensembl_gene_id: ENSLOCP00000008576
symbol: kif11
gene_biotype: protein_coding
description:
  Kinesin family member 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.


ensembl_gene_id: ENSLOCP00000008603
symbol: hoxd9
gene_biotype: protein_coding
description:
  Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family.


ensembl_gene_id: ENSLOCP00000008615
symbol: slc2a5
gene_biotype: protein_coding
description:
  Solute carrier family 2 member 5; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.


ensembl_gene_id: ENSLOCP00000008627
symbol: ywhae
gene_biotype: protein_coding
description:
  Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1; Belongs to the 14-3-3 family.


ensembl_gene_id: ENSLOCP00000008633
symbol: coq7
gene_biotype: protein_coding
description:
  5-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone- independent manner.


ensembl_gene_id: ENSLOCP00000008695
symbol: W5MJY6_LEPOC
gene_biotype: protein_coding
description:
  Kinesin family member 5B, a; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.


ensembl_gene_id: ENSLOCP00000008744
symbol: atf2
gene_biotype: protein_coding
description:
  Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family.


ensembl_gene_id: ENSLOCP00000008757
symbol: arpc3
gene_biotype: protein_coding
description:
  Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.


ensembl_gene_id: ENSLOCP00000008775
symbol: gpn3
gene_biotype: protein_coding
description:
  GPN-loop GTPase 3; Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family.


ensembl_gene_id: ENSLOCP00000008791
symbol: DNTT
gene_biotype: protein_coding
description:
  DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator.


ensembl_gene_id: ENSLOCP00000008798
symbol: W5MK89_LEPOC
gene_biotype: protein_coding
description:
  ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.


ensembl_gene_id: ENSLOCP00000008827
symbol: vps29
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.


ensembl_gene_id: ENSLOCP00000008833
symbol: W5MKC4_LEPOC
gene_biotype: protein_coding
description:
  Translocon-associated protein subunit beta; TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.


ensembl_gene_id: ENSLOCP00000008884
symbol: W5MKH5_LEPOC
gene_biotype: protein_coding
description:
  Solute carrier family 2 member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.


ensembl_gene_id: ENSLOCP00000008891
symbol: mpv17l
gene_biotype: protein_coding
description:
  MPV17 mitochondrial inner membrane protein like; Belongs to the peroxisomal membrane protein PXMP2/4 family.


ensembl_gene_id: ENSLOCP00000008899
symbol: gabrp
gene_biotype: protein_coding
description:
  Gamma-aminobutyric acid (GABA) A receptor, zeta; Belongs to the ligand-gated ion channel (TC 1.A.9) family.


ensembl_gene_id: ENSLOCP00000008941
symbol: bambi
gene_biotype: protein_coding
description:
  BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.


ensembl_gene_id: ENSLOCP00000008977
symbol: adcy7
gene_biotype: protein_coding
description:
  Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.


ensembl_gene_id: ENSLOCP00000008982
symbol: ola1
gene_biotype: protein_coding
description:
  Obg-like ATPase 1; Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.


ensembl_gene_id: ENSLOCP00000008987
symbol: eif3g
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 3 subunit G; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA.


ensembl_gene_id: ENSLOCP00000008991
symbol: med17
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 17; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.


ensembl_gene_id: ENSLOCP00000009017
symbol: bop1
gene_biotype: protein_coding
description:
  Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.


ensembl_gene_id: ENSLOCP00000009039
symbol: W5MKY0_LEPOC
gene_biotype: protein_coding
description:
  Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.


ensembl_gene_id: ENSLOCP00000009053
symbol: dnmt1
gene_biotype: protein_coding
description:
  DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.


ensembl_gene_id: ENSLOCP00000009064
symbol: phka2
gene_biotype: protein_coding
description:
  Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family.


ensembl_gene_id: ENSLOCP00000009108
symbol: ywhab
gene_biotype: protein_coding
description:
  Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide a; Belongs to the 14-3-3 family.


ensembl_gene_id: ENSLOCP00000009125
symbol: mre11
gene_biotype: protein_coding
description:
  Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.


ensembl_gene_id: ENSLOCP00000009153
symbol: ppp2r2d
gene_biotype: protein_coding
description:
  Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family.


ensembl_gene_id: ENSLOCP00000009164
symbol: W5MLA5_LEPOC
gene_biotype: protein_coding
description:
  MICOS complex subunit MIC10; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.


ensembl_gene_id: ENSLOCP00000009181
symbol: W5MLC2_LEPOC
gene_biotype: protein_coding
description:
  F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.


ensembl_gene_id: ENSLOCP00000009201
symbol: polr3k
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.


ensembl_gene_id: ENSLOCP00000009246
symbol: metap1d
gene_biotype: protein_coding
description:
  Methionyl aminopeptidase type 1D (mitochondrial); Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.


ensembl_gene_id: ENSLOCP00000009253
symbol: W5MLJ4_LEPOC
gene_biotype: protein_coding
description:
  3-hydroxybutyrate dehydrogenase, type 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family.


ensembl_gene_id: ENSLOCP00000009278
symbol: rbp5
gene_biotype: protein_coding
description:
  Retinol binding protein 1a, cellular; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.


ensembl_gene_id: ENSLOCP00000009281
symbol: hat1
gene_biotype: protein_coding
description:
  Histone acetyltransferase type B catalytic subunit; Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG.


ensembl_gene_id: ENSLOCP00000009298
symbol: W5MLN9_LEPOC
gene_biotype: protein_coding
description:
  Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.


ensembl_gene_id: ENSLOCP00000009329
symbol: kif14
gene_biotype: protein_coding
description:
  Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.


ensembl_gene_id: ENSLOCP00000009345
symbol: W5MLT6_LEPOC
gene_biotype: protein_coding
description:
  Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.


ensembl_gene_id: ENSLOCP00000009401
symbol: elovl7
gene_biotype: protein_coding
description:
  Elongation of very long chain fatty acids protein 7; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0 [...]


ensembl_gene_id: ENSLOCP00000009408
symbol: sema6c
gene_biotype: protein_coding
description:
  Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D; Belongs to the semaphorin family.


ensembl_gene_id: ENSLOCP00000009427
symbol: eif6
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.


ensembl_gene_id: ENSLOCP00000009441
symbol: ago2
gene_biotype: protein_coding
description:
  Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]


ensembl_gene_id: ENSLOCP00000009447
symbol: ap1m2
gene_biotype: protein_coding
description:
  AP-1 complex subunit mu-2; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.


ensembl_gene_id: ENSLOCP00000009514
symbol: dimt1
gene_biotype: protein_coding
description:
  rRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.


ensembl_gene_id: ENSLOCP00000009545
symbol: LOC102694326
gene_biotype: protein_coding
description:
  Endosulfine alpha a; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. Belongs to the endosulfine family.


ensembl_gene_id: ENSLOCP00000009555
symbol: nup93
gene_biotype: protein_coding
description:
  Nuclear pore complex protein Nup93; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance; Belongs to the nucleoporin interacting component (NIC) family.


ensembl_gene_id: ENSLOCP00000009582
symbol: rnaseh2a
gene_biotype: protein_coding
description:
  Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.


ensembl_gene_id: ENSLOCP00000009585
symbol: W5MMH6_LEPOC
gene_biotype: protein_coding
description:
  E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.


ensembl_gene_id: ENSLOCP00000009588
symbol: trpc1
gene_biotype: protein_coding
description:
  Transient receptor potential cation channel, subfamily C, member 1; Belongs to the transient receptor (TC 1.A.4) family.


ensembl_gene_id: ENSLOCP00000009601
symbol: LOC107076668
gene_biotype: protein_coding
description:
  Transient receptor potential cation channel subfamily C member 2b; Belongs to the transient receptor (TC 1.A.4) family.


ensembl_gene_id: ENSLOCP00000009627
symbol: W5MML8_LEPOC
gene_biotype: protein_coding
description:
  Ornithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily.


ensembl_gene_id: ENSLOCP00000009635
symbol: W5MMM6_LEPOC
gene_biotype: protein_coding
description:
  Aldehyde dehydrogenase 2 family member, tandem duplicate 2; Belongs to the aldehyde dehydrogenase family.


ensembl_gene_id: ENSLOCP00000009640
symbol: hspb7
gene_biotype: protein_coding
description:
  Heat shock protein family, member 7 (cardiovascular); Belongs to the small heat shock protein (HSP20) family.


ensembl_gene_id: ENSLOCP00000009651
symbol: LOC102694696
gene_biotype: protein_coding
description:
  Cytochrome c oxidase subunit; This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.


ensembl_gene_id: ENSLOCP00000009653
symbol: rrm1
gene_biotype: protein_coding
description:
  Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.


ensembl_gene_id: ENSLOCP00000009668
symbol: get3
gene_biotype: protein_coding
description:
  ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion.  [...]


ensembl_gene_id: ENSLOCP00000009685
symbol: phgdh
gene_biotype: protein_coding
description:
  D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.


ensembl_gene_id: ENSLOCP00000009708
symbol: mboat7
gene_biotype: protein_coding
description:
  Membrane bound O-acyltransferase domain containing 7; Belongs to the membrane-bound acyltransferase family.


ensembl_gene_id: ENSLOCP00000009724
symbol: nudt21
gene_biotype: protein_coding
description:
  Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The  [...]


ensembl_gene_id: ENSLOCP00000009726
symbol: W5MMW7_LEPOC
gene_biotype: protein_coding
description:
  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across t [...]


ensembl_gene_id: ENSLOCP00000009727
symbol: oxct1
gene_biotype: protein_coding
description:
  Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.


ensembl_gene_id: ENSLOCP00000009744
symbol: atp1b3
gene_biotype: protein_coding
description:
  Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.


ensembl_gene_id: ENSLOCP00000009752
symbol: MED19
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 19; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.


ensembl_gene_id: ENSLOCP00000009764
symbol: eef1akmt2
gene_biotype: protein_coding
description:
  EEF1A lysine methyltransferase 2; Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-318'; Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.


ensembl_gene_id: ENSLOCP00000009781
symbol: LOC102692451
gene_biotype: protein_coding
description:
  U2 snRNP auxiliary factor large subunit; Necessary for the splicing of pre-mRNA. Belongs to the splicing factor SR family.


ensembl_gene_id: ENSLOCP00000009826
symbol: ATP5F1B
gene_biotype: protein_coding
description:
  ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane.


ensembl_gene_id: ENSLOCP00000009836
symbol: oat
gene_biotype: protein_coding
description:
  Ornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.


ensembl_gene_id: ENSLOCP00000009842
symbol: etfdh
gene_biotype: protein_coding
description:
  Electron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone.


ensembl_gene_id: ENSLOCP00000009856
symbol: rp2
gene_biotype: protein_coding
description:
  Protein XRP2; Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization.


ensembl_gene_id: ENSLOCP00000009859
symbol: atg12
gene_biotype: protein_coding
description:
  Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.


ensembl_gene_id: ENSLOCP00000009886
symbol: rhbg
gene_biotype: protein_coding
description:
  Rh family, B glycoprotein (gene/pseudogene); Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.


ensembl_gene_id: ENSLOCP00000009893
symbol: W5MND4_LEPOC
gene_biotype: protein_coding
description:
  Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family.


ensembl_gene_id: ENSLOCP00000009903
symbol: elof1
gene_biotype: protein_coding
description:
  Transcription elongation factor 1 homolog; Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions. Belongs to the ELOF1 family.


ensembl_gene_id: ENSLOCP00000009911
symbol: atp6v0d1
gene_biotype: protein_coding
description:
  V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family.


ensembl_gene_id: ENSLOCP00000009941
symbol: hsd11b2
gene_biotype: protein_coding
description:
  Hydroxysteroid (11-beta) dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family.


ensembl_gene_id: ENSLOCP00000009953
symbol: LOC102698357
gene_biotype: protein_coding
description:
  Cytochrome b-c1 complex subunit 7; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain; Belongs to the UQCRB/QCR7 family.


ensembl_gene_id: ENSLOCP00000009997
symbol: ror2
gene_biotype: protein_coding
description:
  Receptor tyrosine kinase-like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.


ensembl_gene_id: ENSLOCP00000010004
symbol: LOC102694648
gene_biotype: protein_coding
description:
  Transient receptor potential cation channel, subfamily V, member 6; Belongs to the transient receptor (TC 1.A.4) family.


ensembl_gene_id: ENSLOCP00000010007
symbol: tdo2
gene_biotype: protein_coding
description:
  Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.


ensembl_gene_id: ENSLOCP00000010021
symbol: KIF13A
gene_biotype: protein_coding
description:
  Kinesin family member 13A; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.


ensembl_gene_id: ENSLOCP00000010026
symbol: gucy1a1
gene_biotype: protein_coding
description:
  Guanylate cyclase 1 soluble subunit alpha 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.


ensembl_gene_id: ENSLOCP00000010028
symbol: dpyd
gene_biotype: protein_coding
description:
  Dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine; Belongs to the dihydropyrimidine dehydrogenase family.


ensembl_gene_id: ENSLOCP00000010102
symbol: GABRG3
gene_biotype: protein_coding
description:
  Gamma-aminobutyric acid type A receptor gamma3 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family.


ensembl_gene_id: ENSLOCP00000010119
symbol: gabra5
gene_biotype: protein_coding
description:
  Gamma-aminobutyric acid (GABA) A receptor, alpha 5; Belongs to the ligand-gated ion channel (TC 1.A.9) family.


ensembl_gene_id: ENSLOCP00000010135
symbol: W5MP26_LEPOC
gene_biotype: protein_coding
description:
  FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...]


ensembl_gene_id: ENSLOCP00000010136
symbol: gabrb3
gene_biotype: protein_coding
description:
  Gamma-aminobutyric acid type A receptor beta3 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family.


ensembl_gene_id: ENSLOCP00000010144
symbol: LOC102689735
gene_biotype: protein_coding
description:
  Uricase; Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin. Belongs to the uricase family.


ensembl_gene_id: ENSLOCP00000010161
symbol: ap2m1
gene_biotype: protein_coding
description:
  AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...]


ensembl_gene_id: ENSLOCP00000010189
symbol: ube3a
gene_biotype: protein_coding
description:
  Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.


ensembl_gene_id: ENSLOCP00000010260
symbol: SLC8B1
gene_biotype: protein_coding
description:
  Solute carrier family 8 member B1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.


ensembl_gene_id: ENSLOCP00000010294
symbol: W5MPI5_LEPOC
gene_biotype: protein_coding
description:
  RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.


ensembl_gene_id: ENSLOCP00000010313
symbol: W5MPK4_LEPOC
gene_biotype: protein_coding
description:
  TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family.


ensembl_gene_id: ENSLOCP00000010320
symbol: kcnk10
gene_biotype: protein_coding
description:
  Potassium channel, subfamily K, member 10a; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.


ensembl_gene_id: ENSLOCP00000010373
symbol: W5MPR4_LEPOC
gene_biotype: protein_coding
description:
  Eukaryotic translation elongation factor 1 delta b (guanine nucleotide exchange protein); Belongs to the EF-1-beta/EF-1-delta family.


ensembl_gene_id: ENSLOCP00000010405
symbol: trpc4
gene_biotype: protein_coding
description:
  Transient receptor potential cation channel, subfamily C, member 4b; Belongs to the transient receptor (TC 1.A.4) family.


ensembl_gene_id: ENSLOCP00000010419
symbol: GATB
gene_biotype: protein_coding
description:
  Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Belongs to the GatB/GatE family. GatB subfamily.


ensembl_gene_id: ENSLOCP00000010438
symbol: grina
gene_biotype: protein_coding
description:
  Glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1a (glutamate binding); Belongs to the BI1 family.


ensembl_gene_id: ENSLOCP00000010441
symbol: W5MPY2_LEPOC
gene_biotype: protein_coding
description:
  Mitochondrial pyruvate carrier; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.


ensembl_gene_id: ENSLOCP00000010472
symbol: vps28
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.


ensembl_gene_id: ENSLOCP00000010488
symbol: W5MQ29_LEPOC
gene_biotype: protein_coding
description:
  Adhesion G protein-coupled receptor E5b, duplicate 3; Belongs to the G-protein coupled receptor 2 family.


ensembl_gene_id: ENSLOCP00000010530
symbol: psap
gene_biotype: protein_coding
description:
  Prosaposin; Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling.


ensembl_gene_id: ENSLOCP00000010562
symbol: coq5
gene_biotype: protein_coding
description:
  Tuftelin-interacting protein 11; Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Belongs to the TFP11/STIP family.


ensembl_gene_id: ENSLOCP00000010610
symbol: psmd2
gene_biotype: protein_coding
description:
  26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family.


ensembl_gene_id: ENSLOCP00000010632
symbol: slc40a1
gene_biotype: protein_coding
description:
  Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.


ensembl_gene_id: ENSLOCP00000010646
symbol: srd5a1
gene_biotype: protein_coding
description:
  3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology.


ensembl_gene_id: ENSLOCP00000010664
symbol: nsun2
gene_biotype: protein_coding
description:
  NOP2/Sun RNA methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.


ensembl_gene_id: ENSLOCP00000010669
symbol: prmt9
gene_biotype: protein_coding
description:
  Protein arginine methyltransferase 9; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.


ensembl_gene_id: ENSLOCP00000010684
symbol: ATE1
gene_biotype: protein_coding
description:
  Arginyl-tRNA--protein transferase 1; Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Belongs to the R-transferase family.


ensembl_gene_id: ENSLOCP00000010691
symbol: osgepl1
gene_biotype: protein_coding
description:
  Probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.


ensembl_gene_id: ENSLOCP00000010693
symbol: med10
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 10; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.


ensembl_gene_id: ENSLOCP00000010698
symbol: nsmce4a
gene_biotype: protein_coding
description:
  Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.


ensembl_gene_id: ENSLOCP00000010748
symbol: slc10a7
gene_biotype: protein_coding
description:
  Sodium/bile acid cotransporter; Does not show transport activity towards bile acids or steroid sulfates; Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.


ensembl_gene_id: ENSLOCP00000010753
symbol: hibch
gene_biotype: protein_coding
description:
  3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.


ensembl_gene_id: ENSLOCP00000010806
symbol: sema6a
gene_biotype: protein_coding
description:
  Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A; Belongs to the semaphorin family.


ensembl_gene_id: ENSLOCP00000010854
symbol: tshr
gene_biotype: protein_coding
description:
  Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.


ensembl_gene_id: ENSLOCP00000010867
symbol: anapc10
gene_biotype: protein_coding
description:
  Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.


ensembl_gene_id: ENSLOCP00000010891
symbol: W5MR82_LEPOC
gene_biotype: protein_coding
description:
  Uncharacterized protein; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.


ensembl_gene_id: ENSLOCP00000010896
symbol: atp6v0c
gene_biotype: protein_coding
description:
  V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.


ensembl_gene_id: ENSLOCP00000010903
symbol: qtrt1
gene_biotype: protein_coding
description:
  Queuine tRNA-ribosyltransferase catalytic subunit 1; Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, formi [...]


ensembl_gene_id: ENSLOCP00000010906
symbol: STON2
gene_biotype: protein_coding
description:
  Stonin-2; Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating; Belongs to the Stoned B family.


ensembl_gene_id: ENSLOCP00000010907
symbol: mboat1
gene_biotype: protein_coding
description:
  Membrane bound O-acyltransferase domain containing 1; Belongs to the membrane-bound acyltransferase family.


ensembl_gene_id: ENSLOCP00000010943
symbol: FTSJ3
gene_biotype: protein_coding
description:
  pre-rRNA processing protein FTSJ3; Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.


ensembl_gene_id: ENSLOCP00000010946
symbol: LOC102694802
gene_biotype: protein_coding
description:
  V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.


ensembl_gene_id: ENSLOCP00000010956
symbol: W5MRE7_LEPOC
gene_biotype: protein_coding
description:
  N-acetylglucosamine-6-phosphate deacetylase; Belongs to the metallo-dependent hydrolases superfamily. NagA family.


ensembl_gene_id: ENSLOCP00000010974
symbol: kcnk13
gene_biotype: protein_coding
description:
  Potassium channel, subfamily K, member 13a; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.


ensembl_gene_id: ENSLOCP00000011016
symbol: W5MRK7_LEPOC
gene_biotype: protein_coding
description:
  ATP-dependent (S)-NAD(P)H-hydrate dehydratase; Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S-and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.


ensembl_gene_id: ENSLOCP00000011055
symbol: st8sia4
gene_biotype: protein_coding
description:
  ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4; Belongs to the glycosyltransferase 29 family.


ensembl_gene_id: ENSLOCP00000011071
symbol: rbm8a
gene_biotype: protein_coding
description:
  RNA-binding protein 8A; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.


ensembl_gene_id: ENSLOCP00000011080
symbol: MYH11
gene_biotype: protein_coding
description:
  Myosin heavy chain 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.


ensembl_gene_id: ENSLOCP00000011113
symbol: W5MRV4_LEPOC
gene_biotype: protein_coding
description:
  Si:ch1073-184j22.2; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.


ensembl_gene_id: ENSLOCP00000011123
symbol: W5MRW4_LEPOC
gene_biotype: protein_coding
description:
  Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates  [...]


ensembl_gene_id: ENSLOCP00000011159
symbol: sod1
gene_biotype: protein_coding
description:
  Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family.


ensembl_gene_id: ENSLOCP00000011183
symbol: arpc2
gene_biotype: protein_coding
description:
  Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.


ensembl_gene_id: ENSLOCP00000011252
symbol: gemin2
gene_biotype: protein_coding
description:
  Gem-associated protein 2; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs; Belongs to the gemin-2 family.


ensembl_gene_id: ENSLOCP00000011257
symbol: hsd17b3
gene_biotype: protein_coding
description:
  Hydroxysteroid (17-beta) dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family.


ensembl_gene_id: ENSLOCP00000011288
symbol: thg1l
gene_biotype: protein_coding
description:
  tRNA(His) guanylyltransferase; Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage.


ensembl_gene_id: ENSLOCP00000011303
symbol: LOC102693433
gene_biotype: protein_coding
description:
  Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.


ensembl_gene_id: ENSLOCP00000011314
symbol: inha
gene_biotype: protein_coding
description:
  Inhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family.


ensembl_gene_id: ENSLOCP00000011374
symbol: LOC102685413
gene_biotype: protein_coding
description:
  Guanylate cyclase 1, soluble, beta 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.


ensembl_gene_id: ENSLOCP00000011391
symbol: LOC102697157
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 4E family member 1c; Belongs to the eukaryotic initiation factor 4E family.


ensembl_gene_id: ENSLOCP00000011469
symbol: W5MSW0_LEPOC
gene_biotype: protein_coding
description:
  Ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog, yeast); Belongs to the ubiquitin-conjugating enzyme family.


ensembl_gene_id: ENSLOCP00000011495
symbol: sec23a
gene_biotype: protein_coding
description:
  Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily.


ensembl_gene_id: ENSLOCP00000011507
symbol: gba2
gene_biotype: protein_coding
description:
  Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide.


ensembl_gene_id: ENSLOCP00000011529
symbol: srp54
gene_biotype: protein_coding
description:
  Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). Belongs to the GTP-binding SRP family. SRP54 subfamily.


ensembl_gene_id: ENSLOCP00000011630
symbol: egr1
gene_biotype: protein_coding
description:
  Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family.


ensembl_gene_id: ENSLOCP00000011640
symbol: aqp1
gene_biotype: protein_coding
description:
  Aquaporin 1a (Colton blood group), tandem duplicate 1; Belongs to the MIP/aquaporin (TC 1.A.8) family.


ensembl_gene_id: ENSLOCP00000011662
symbol: LOC102698545
gene_biotype: protein_coding
description:
  Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.


ensembl_gene_id: ENSLOCP00000011675
symbol: adcyap1r1
gene_biotype: protein_coding
description:
  Adenylate cyclase activating polypeptide 1a (pituitary) receptor type I; Belongs to the G-protein coupled receptor 2 family.


ensembl_gene_id: ENSLOCP00000011703
symbol: gda
gene_biotype: protein_coding
description:
  Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.


ensembl_gene_id: ENSLOCP00000011711
symbol: ehhadh
gene_biotype: protein_coding
description:
  Enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family.


ensembl_gene_id: ENSLOCP00000011715
symbol: rrp8
gene_biotype: protein_coding
description:
  Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family.


ensembl_gene_id: ENSLOCP00000011761
symbol: psmg2
gene_biotype: protein_coding
description:
  Proteasome assembly chaperone 2; Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. Belongs to the PSMG2 family.


ensembl_gene_id: ENSLOCP00000011781
symbol: smarcal1
gene_biotype: protein_coding
description:
  SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.


ensembl_gene_id: ENSLOCP00000011830
symbol: PRLR
gene_biotype: protein_coding
description:
  Prolactin receptor; This is a receptor for the anterior pituitary hormone prolactin; Belongs to the type I cytokine receptor family. Type 1 subfamily.


ensembl_gene_id: ENSLOCP00000011839
symbol: LOC102694730
gene_biotype: protein_coding
description:
  Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.


ensembl_gene_id: ENSLOCP00000011840
symbol: dusp27
gene_biotype: protein_coding
description:
  Dual specificity phosphatase 27; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.


ensembl_gene_id: ENSLOCP00000011857
symbol: prkd1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.


ensembl_gene_id: ENSLOCP00000011885
symbol: xrcc5
gene_biotype: protein_coding
description:
  X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family.


ensembl_gene_id: ENSLOCP00000011886
symbol: EIF3A
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 3 subunit A; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.


ensembl_gene_id: ENSLOCP00000011891
symbol: tead3
gene_biotype: protein_coding
description:
  Transcriptional enhancer factor TEF-5; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis.


ensembl_gene_id: ENSLOCP00000011942
symbol: ehd4
gene_biotype: protein_coding
description:
  EH-domain containing 4; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.


ensembl_gene_id: ENSLOCP00000011952
symbol: PHYKPL
gene_biotype: protein_coding
description:
  5-phosphohydroxy-L-lysine phospho-lyase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.


ensembl_gene_id: ENSLOCP00000011973
symbol: LOC102687759
gene_biotype: protein_coding
description:
  Thymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family.


ensembl_gene_id: ENSLOCP00000011985
symbol: RNF168
gene_biotype: protein_coding
description:
  E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...]


ensembl_gene_id: ENSLOCP00000011990
symbol: myd88
gene_biotype: protein_coding
description:
  Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.


ensembl_gene_id: ENSLOCP00000012040
symbol: W5MUI1_LEPOC
gene_biotype: protein_coding
description:
  CDC42 binding protein kinase beta (DMPK-like); Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.


ensembl_gene_id: ENSLOCP00000012070
symbol: LOC102694874
gene_biotype: protein_coding
description:
  Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.


ensembl_gene_id: ENSLOCP00000012126
symbol: trmt61a
gene_biotype: protein_coding
description:
  tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A; Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.


ensembl_gene_id: ENSLOCP00000012153
symbol: SLC2A9
gene_biotype: protein_coding
description:
  Solute carrier family 2 member 9; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.


ensembl_gene_id: ENSLOCP00000012157
symbol: atp6v1c1
gene_biotype: protein_coding
description:
  V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.


ensembl_gene_id: ENSLOCP00000012166
symbol: W5MUV7_LEPOC
gene_biotype: protein_coding
description:
  DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily.


ensembl_gene_id: ENSLOCP00000012228
symbol: eif4e3
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 4E family member 3; Belongs to the eukaryotic initiation factor 4E family.


ensembl_gene_id: ENSLOCP00000012242
symbol: coq2
gene_biotype: protein_coding
description:
  4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.


ensembl_gene_id: ENSLOCP00000012244
symbol: zranb2
gene_biotype: protein_coding
description:
  Zinc finger Ran-binding domain-containing protein 2; May interfere with constitutive 5'-splice site selection. Belongs to the ZRANB2 family.


ensembl_gene_id: ENSLOCP00000012284
symbol: gldc
gene_biotype: protein_coding
description:
  Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine.


ensembl_gene_id: ENSLOCP00000012308
symbol: dhrs7
gene_biotype: protein_coding
description:
  Dehydrogenase/reductase (SDR family) member 7; Belongs to the short-chain dehydrogenases/reductases (SDR) family.


ensembl_gene_id: ENSLOCP00000012330
symbol: timm17a
gene_biotype: protein_coding
description:
  Mitochondrial import inner membrane translocase subunit TIM17; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.


ensembl_gene_id: ENSLOCP00000012334
symbol: ndufa10
gene_biotype: protein_coding
description:
  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.


ensembl_gene_id: ENSLOCP00000012372
symbol: mnat1
gene_biotype: protein_coding
description:
  CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex.


ensembl_gene_id: ENSLOCP00000012385
symbol: trmt5
gene_biotype: protein_coding
description:
  tRNA (guanine(37)-N1)-methyltransferase; Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding; Belongs to the TRM5 / TYW2 family.


ensembl_gene_id: ENSLOCP00000012442
symbol: suclg2
gene_biotype: protein_coding
description:
  Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial; GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.


ensembl_gene_id: ENSLOCP00000012446
symbol: dhx29
gene_biotype: protein_coding
description:
  ATP-dependent RNA helicase DHX29; ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity; Belongs to the DEAD box helicase family. DEAH subfamily.


ensembl_gene_id: ENSLOCP00000012464
symbol: grpel1
gene_biotype: protein_coding
description:
  GrpE protein homolog; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the GrpE family.


ensembl_gene_id: ENSLOCP00000012478
symbol: cmpk1
gene_biotype: protein_coding
description:
  UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.


ensembl_gene_id: ENSLOCP00000012502
symbol: wdr12
gene_biotype: protein_coding
description:
  Ribosome biogenesis protein WDR12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.


ensembl_gene_id: ENSLOCP00000012510
symbol: ube2b
gene_biotype: protein_coding
description:
  Ubiquitin-conjugating enzyme E2B (RAD6 homolog); Belongs to the ubiquitin-conjugating enzyme family.


ensembl_gene_id: ENSLOCP00000012519
symbol: ppp2r5e
gene_biotype: protein_coding
description:
  Serine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit.


ensembl_gene_id: ENSLOCP00000012598
symbol: septin10
gene_biotype: protein_coding
description:
  Septin 10; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.


ensembl_gene_id: ENSLOCP00000012629
symbol: W5MW70_LEPOC
gene_biotype: protein_coding
description:
  Solute carrier family 2 member 9, like 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.


ensembl_gene_id: ENSLOCP00000012633
symbol: serpine3
gene_biotype: protein_coding
description:
  Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3; Belongs to the serpin family.


ensembl_gene_id: ENSLOCP00000012635
symbol: capza1
gene_biotype: protein_coding
description:
  F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.


ensembl_gene_id: ENSLOCP00000012687
symbol: kcnd3
gene_biotype: protein_coding
description:
  Potassium voltage-gated channel, Shal-related subfamily, member 3; Belongs to the potassium channel family.


ensembl_gene_id: ENSLOCP00000012775
symbol: itpa
gene_biotype: protein_coding
description:
  Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family.


ensembl_gene_id: ENSLOCP00000012783
symbol: nmt2
gene_biotype: protein_coding
description:
  Glycylpeptide N-tetradecanoyltransferase; Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins; Belongs to the NMT family.


ensembl_gene_id: ENSLOCP00000012787
symbol: SUCLA2
gene_biotype: protein_coding
description:
  Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.


ensembl_gene_id: ENSLOCP00000012810
symbol: W5MWQ1_LEPOC
gene_biotype: protein_coding
description:
  Tyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.


ensembl_gene_id: ENSLOCP00000012820
symbol: W5MWR1_LEPOC
gene_biotype: protein_coding
description:
  NOP2/Sun RNA methyltransferase 3; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.


ensembl_gene_id: ENSLOCP00000012856
symbol: eif2b2
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 2B, subunit 2 beta; Belongs to the eIF-2B alpha/beta/delta subunits family.


ensembl_gene_id: ENSLOCP00000012915
symbol: LOC102693163
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.


ensembl_gene_id: ENSLOCP00000012917
symbol: FGF1
gene_biotype: protein_coding
description:
  Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]


ensembl_gene_id: ENSLOCP00000012938
symbol: trdmt1
gene_biotype: protein_coding
description:
  tRNA aspartic acid methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.


ensembl_gene_id: ENSLOCP00000012939
symbol: W5MX30_LEPOC
gene_biotype: protein_coding
description:
  UDP glucuronosyltransferase 1 family, polypeptide B5; Belongs to the UDP-glycosyltransferase family.


ensembl_gene_id: ENSLOCP00000012953
symbol: prmt2
gene_biotype: protein_coding
description:
  Protein arginine methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.


ensembl_gene_id: ENSLOCP00000012979
symbol: LOC102687658
gene_biotype: protein_coding
description:
  Vesicle transport protein; May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex. Belongs to the SFT2 family.


ensembl_gene_id: ENSLOCP00000013035
symbol: LOC102691398
gene_biotype: protein_coding
description:
  Oxytocin receptor like; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.


ensembl_gene_id: ENSLOCP00000013046
symbol: cav3
gene_biotype: protein_coding
description:
  Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.


ensembl_gene_id: ENSLOCP00000013048
symbol: LOC102690258
gene_biotype: protein_coding
description:
  Solute carrier family 5 member 8, like; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.


ensembl_gene_id: ENSLOCP00000013057
symbol: septin8
gene_biotype: protein_coding
description:
  Septin 8a; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.


ensembl_gene_id: ENSLOCP00000013072
symbol: W5MXG3_LEPOC
gene_biotype: protein_coding
description:
  Tubulin, alpha 8 like 3; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.


ensembl_gene_id: ENSLOCP00000013097
symbol: gabrg2
gene_biotype: protein_coding
description:
  Gamma-aminobutyric acid (GABA) A receptor, gamma 2; Belongs to the ligand-gated ion channel (TC 1.A.9) family.


ensembl_gene_id: ENSLOCP00000013105
symbol: W5MXJ6_LEPOC
gene_biotype: protein_coding
description:
  Voltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the low-voltage activated (LVA) group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...]


ensembl_gene_id: ENSLOCP00000013107
symbol: gabra1
gene_biotype: protein_coding
description:
  Gamma-aminobutyric acid (GABA) A receptor, alpha 1; Belongs to the ligand-gated ion channel (TC 1.A.9) family.


ensembl_gene_id: ENSLOCP00000013119
symbol: W5MXL0_LEPOC
gene_biotype: protein_coding
description:
  Gamma-aminobutyric acid (GABA) A receptor, alpha 6a; Belongs to the ligand-gated ion channel (TC 1.A.9) family.


ensembl_gene_id: ENSLOCP00000013134
symbol: W5MXM5_LEPOC
gene_biotype: protein_coding
description:
  Gamma-aminobutyric acid type A receptor beta2 subunit a; Belongs to the ligand-gated ion channel (TC 1.A.9) family.


ensembl_gene_id: ENSLOCP00000013136
symbol: blvra
gene_biotype: protein_coding
description:
  Biliverdin reductase A; Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor; Belongs to the Gfo/Idh/MocA family. Biliverdin reductase subfamily.


ensembl_gene_id: ENSLOCP00000013141
symbol: enoph1
gene_biotype: protein_coding
description:
  Enolase-phosphatase E1; Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).


ensembl_gene_id: ENSLOCP00000013163
symbol: atp5pf
gene_biotype: protein_coding
description:
  ATP synthase-coupling factor 6, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain; Belongs to the eukaryotic ATPase subunit F6 family.


ensembl_gene_id: ENSLOCP00000013189
symbol: LOC102682419
gene_biotype: protein_coding
description:
  S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP.


ensembl_gene_id: ENSLOCP00000013256
symbol: SLC26A9
gene_biotype: protein_coding
description:
  Solute carrier family 26 member 9; DIDS- and thiosulfate- sensitive anion exchanger mediating chloride, sulfate and oxalate transport. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.


ensembl_gene_id: ENSLOCP00000013268
symbol: dhrs7c
gene_biotype: protein_coding
description:
  Dehydrogenase/reductase (SDR family) member 7Ca; Belongs to the short-chain dehydrogenases/reductases (SDR) family.


ensembl_gene_id: ENSLOCP00000013273
symbol: gart
gene_biotype: protein_coding
description:
  Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family.  In the central section; belongs to the AIR synthase family.


ensembl_gene_id: ENSLOCP00000013311
symbol: nsun6
gene_biotype: protein_coding
description:
  NOP2/Sun RNA methyltransferase 6; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.


ensembl_gene_id: ENSLOCP00000013312
symbol: W5MY53_LEPOC
gene_biotype: protein_coding
description:
  MICOS complex subunit MIC60; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.


ensembl_gene_id: ENSLOCP00000013358
symbol: eef1akmt1
gene_biotype: protein_coding
description:
  EEF1A lysine methyltransferase 1; Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'; Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.


ensembl_gene_id: ENSLOCP00000013395
symbol: sema3f
gene_biotype: protein_coding
description:
  Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Fb; Belongs to the semaphorin family.


ensembl_gene_id: ENSLOCP00000013407
symbol: sap18
gene_biotype: protein_coding
description:
  Histone deacetylase complex subunit SAP18; Involved in the tethering of the SIN3 complex to core histone proteins.


ensembl_gene_id: ENSLOCP00000013447
symbol: hmgcs1
gene_biotype: protein_coding
description:
  3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.


ensembl_gene_id: ENSLOCP00000013462
symbol: hsd3b1
gene_biotype: protein_coding
description:
  Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1; Belongs to the 3-beta-HSD family.


ensembl_gene_id: ENSLOCP00000013494
symbol: coq6
gene_biotype: protein_coding
description:
  Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.


ensembl_gene_id: ENSLOCP00000013509
symbol: wars2
gene_biotype: protein_coding
description:
  Tryptophanyl tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family.


ensembl_gene_id: ENSLOCP00000013565
symbol: slc24a2
gene_biotype: protein_coding
description:
  Solute carrier family 24 member 2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.


ensembl_gene_id: ENSLOCP00000013585
symbol: C1GALT1
gene_biotype: protein_coding
description:
  Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1; Glycosyltransferase that generates the core 1 O-glycan Gal- beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins; Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.


ensembl_gene_id: ENSLOCP00000013625
symbol: csf1r
gene_biotype: protein_coding
description:
  Colony stimulating factor 1 receptor, a; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.


ensembl_gene_id: ENSLOCP00000013637
symbol: pdgfrb
gene_biotype: protein_coding
description:
  Platelet-derived growth factor receptor, beta polypeptide; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.


ensembl_gene_id: ENSLOCP00000013643
symbol: trnt1
gene_biotype: protein_coding
description:
  tRNA nucleotidyl transferase, CCA-adding, 1; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.


ensembl_gene_id: ENSLOCP00000013672
symbol: slc9a3r1
gene_biotype: protein_coding
description:
  Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression.


ensembl_gene_id: ENSLOCP00000013700
symbol: ap5m1
gene_biotype: protein_coding
description:
  Adaptor related protein complex 5 subunit mu 1; Belongs to the adaptor complexes medium subunit family.


ensembl_gene_id: ENSLOCP00000013706
symbol: clta
gene_biotype: protein_coding
description:
  Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.


ensembl_gene_id: ENSLOCP00000013711
symbol: atp5f1a
gene_biotype: protein_coding
description:
  ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane.


ensembl_gene_id: ENSLOCP00000013734
symbol: ndufa2
gene_biotype: protein_coding
description:
  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.


ensembl_gene_id: ENSLOCP00000013754
symbol: LOC102697883
gene_biotype: protein_coding
description:
  UDP-glucose 6-dehydrogenase; Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate. Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.


ensembl_gene_id: ENSLOCP00000013760
symbol: kif21b
gene_biotype: protein_coding
description:
  Kinesin family member 21B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.


ensembl_gene_id: ENSLOCP00000013775
symbol: st8sia5
gene_biotype: protein_coding
description:
  ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5; Belongs to the glycosyltransferase 29 family.


ensembl_gene_id: ENSLOCP00000013780
symbol: W5MZH1_LEPOC
gene_biotype: protein_coding
description:
  Ethanolamine-phosphate phospho-lyase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.


ensembl_gene_id: ENSLOCP00000013794
symbol: ostc
gene_biotype: protein_coding
description:
  Oligosaccharyltransferase complex subunit; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All s [...]


ensembl_gene_id: ENSLOCP00000013803
symbol: cacng2
gene_biotype: protein_coding
description:
  Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.


ensembl_gene_id: ENSLOCP00000013813
symbol: ak3
gene_biotype: protein_coding
description:
  GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.


ensembl_gene_id: ENSLOCP00000013833
symbol: W5MZM4_LEPOC
gene_biotype: protein_coding
description:
  Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.


ensembl_gene_id: ENSLOCP00000013856
symbol: myc
gene_biotype: protein_coding
description:
  Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.


ensembl_gene_id: ENSLOCP00000013866
symbol: ST6GALNAC1
gene_biotype: protein_coding
description:
  ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; Belongs to the glycosyltransferase 29 family.


ensembl_gene_id: ENSLOCP00000013890
symbol: ST6GALNAC2
gene_biotype: protein_coding
description:
  ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; Belongs to the glycosyltransferase 29 family.


ensembl_gene_id: ENSLOCP00000013910
symbol: slc20a2
gene_biotype: protein_coding
description:
  Phosphate transporter; Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport. Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.


ensembl_gene_id: ENSLOCP00000013941
symbol: vps41
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways; Belongs to the VPS41 family.


ensembl_gene_id: ENSLOCP00000013946
symbol: trpc7
gene_biotype: protein_coding
description:
  Transient receptor potential cation channel, subfamily C, member 7b; Belongs to the transient receptor (TC 1.A.4) family.


ensembl_gene_id: ENSLOCP00000014023
symbol: DNAAF2
gene_biotype: protein_coding
description:
  Protein kintoun; Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment. Belongs to the PIH1 family. Kintoun subfamily.


ensembl_gene_id: ENSLOCP00000014050
symbol: pole2
gene_biotype: protein_coding
description:
  DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family.


ensembl_gene_id: ENSLOCP00000014052
symbol: polr2b
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.


ensembl_gene_id: ENSLOCP00000014134
symbol: ret
gene_biotype: protein_coding
description:
  Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands.


ensembl_gene_id: ENSLOCP00000014145
symbol: cept1
gene_biotype: protein_coding
description:
  Choline/ethanolamine phosphotransferase 1b; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.


ensembl_gene_id: ENSLOCP00000014149
symbol: LOC102697805
gene_biotype: protein_coding
description:
  Pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha.


ensembl_gene_id: ENSLOCP00000014192
symbol: W5N0N3_LEPOC
gene_biotype: protein_coding
description:
  Elongator complex protein 1; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. Belongs to the ELP1/IKA1 family.


ensembl_gene_id: ENSLOCP00000014250
symbol: W5N0U1_LEPOC
gene_biotype: protein_coding
description:
  Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.


ensembl_gene_id: ENSLOCP00000014310
symbol: GABRB1
gene_biotype: protein_coding
description:
  Gamma-aminobutyric acid type A receptor beta1 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family.


ensembl_gene_id: ENSLOCP00000014343
symbol: LOC102682306
gene_biotype: protein_coding
description:
  Solute carrier family 2 member 15a; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.


ensembl_gene_id: ENSLOCP00000014394
symbol: GAR1
gene_biotype: protein_coding
description:
  H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine (psi) residues may serve to stabilize the conformation of rRNAs.


ensembl_gene_id: ENSLOCP00000014408
symbol: W5N199_LEPOC
gene_biotype: protein_coding
description:
  Retinal pigment epithelium-derived rhodopsin homolog; Belongs to the G-protein coupled receptor 1 family.


ensembl_gene_id: ENSLOCP00000014421
symbol: riok1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase RIO1; Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.


ensembl_gene_id: ENSLOCP00000014459
symbol: elovl6
gene_biotype: protein_coding
description:
  Elongation of very long chain fatty acids protein 6; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degre [...]


ensembl_gene_id: ENSLOCP00000014489
symbol: ina
gene_biotype: protein_coding
description:
  Internexin neuronal intermediate filament protein, alpha b; Belongs to the intermediate filament family.


ensembl_gene_id: ENSLOCP00000014521
symbol: W5N1L2_LEPOC
gene_biotype: protein_coding
description:
  Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.


ensembl_gene_id: ENSLOCP00000014553
symbol: eif4e1b
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 4E family member 1B; Belongs to the eukaryotic initiation factor 4E family.


ensembl_gene_id: ENSLOCP00000014580
symbol: msrb2
gene_biotype: protein_coding
description:
  Peptide-methionine (R)-S-oxide reductase; Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues.


ensembl_gene_id: ENSLOCP00000014598
symbol: map4k5
gene_biotype: protein_coding
description:
  Mitogen-activated protein kinase kinase kinase kinase 5; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.


ensembl_gene_id: ENSLOCP00000014662
symbol: LOC107078266
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.


ensembl_gene_id: ENSLOCP00000014664
symbol: snrpe
gene_biotype: protein_coding
description:
  Small nuclear ribonucleoprotein E; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family.


ensembl_gene_id: ENSLOCP00000014696
symbol: stn1
gene_biotype: protein_coding
description:
  CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication.


ensembl_gene_id: ENSLOCP00000014752
symbol: septin3
gene_biotype: protein_coding
description:
  Septin 3; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.


ensembl_gene_id: ENSLOCP00000014779
symbol: mdm4
gene_biotype: protein_coding
description:
  Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family.


ensembl_gene_id: ENSLOCP00000014780
symbol: asic2
gene_biotype: protein_coding
description:
  Acid-sensing (proton-gated) ion channel 2; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.


ensembl_gene_id: ENSLOCP00000014783
symbol: flt4
gene_biotype: protein_coding
description:
  Fms-related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.


ensembl_gene_id: ENSLOCP00000014788
symbol: W5N2C9_LEPOC
gene_biotype: protein_coding
description:
  Myosin, heavy chain 9a, non-muscle; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.


ensembl_gene_id: ENSLOCP00000014799
symbol: dusp1
gene_biotype: protein_coding
description:
  Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.


ensembl_gene_id: ENSLOCP00000014800
symbol: rpsa
gene_biotype: protein_coding
description:
  40S ribosomal protein SA; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Belongs to the universal ribosomal protein uS2 family.


ensembl_gene_id: ENSLOCP00000014820
symbol: atxn7l3
gene_biotype: protein_coding
description:
  Ataxin-7-like protein 3; Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription.


ensembl_gene_id: ENSLOCP00000014828
symbol: HDAC3
gene_biotype: protein_coding
description:
  Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.


ensembl_gene_id: ENSLOCP00000014889
symbol: LOC102697506
gene_biotype: protein_coding
description:
  Myosin, heavy polypeptide 1.2, skeletal muscle; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.


ensembl_gene_id: ENSLOCP00000014902
symbol: pik3c2b
gene_biotype: protein_coding
description:
  Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta; Belongs to the PI3/PI4-kinase family.


ensembl_gene_id: ENSLOCP00000014905
symbol: SPDL1
gene_biotype: protein_coding
description:
  Protein Spindly; Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex; Belongs to the Spindly family.


ensembl_gene_id: ENSLOCP00000014927
symbol: gsr
gene_biotype: protein_coding
description:
  Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.


ensembl_gene_id: ENSLOCP00000014979
symbol: LOC102685449
gene_biotype: protein_coding
description:
  Sulfate transporter; Sulfate transporter. May play a role in endochondral bone formation; Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.


ensembl_gene_id: ENSLOCP00000014981
symbol: ALDH18A1
gene_biotype: protein_coding
description:
  Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.


ensembl_gene_id: ENSLOCP00000015009
symbol: eif4e
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 4eb; Belongs to the eukaryotic initiation factor 4E family.


ensembl_gene_id: ENSLOCP00000015024
symbol: metap1
gene_biotype: protein_coding
description:
  Methionine aminopeptidase; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val).


ensembl_gene_id: ENSLOCP00000015035
symbol: LOC102685513
gene_biotype: protein_coding
description:
  S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.


ensembl_gene_id: ENSLOCP00000015043
symbol: LOC102689977
gene_biotype: protein_coding
description:
  Sulfate anion transporter 1; Mediates sulfate transport with high affinity. Mediates oxalate transport. Mediates bicarbonate transport. Does not accept succinate as cosubstrate; Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.


ensembl_gene_id: ENSLOCP00000015097
symbol: gosr2
gene_biotype: protein_coding
description:
  Golgi SNAP receptor complex member 2; Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.


ensembl_gene_id: ENSLOCP00000015109
symbol: rbfox3
gene_biotype: protein_coding
description:
  RNA binding protein fox-1 homolog 3; RNA-binding protein that regulates alternative splicing events.


ensembl_gene_id: ENSLOCP00000015113
symbol: gtpbp4
gene_biotype: protein_coding
description:
  Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.


ensembl_gene_id: ENSLOCP00000015133
symbol: chac1
gene_biotype: protein_coding
description:
  Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.


ensembl_gene_id: ENSLOCP00000015235
symbol: gabra4
gene_biotype: protein_coding
description:
  Gamma-aminobutyric acid (GABA) A receptor, subunit alpha 4; Belongs to the ligand-gated ion channel (TC 1.A.9) family.


ensembl_gene_id: ENSLOCP00000015236
symbol: galt
gene_biotype: protein_coding
description:
  Galactose-1-phosphate uridylyltransferase; Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.


ensembl_gene_id: ENSLOCP00000015248
symbol: gabra2
gene_biotype: protein_coding
description:
  Gamma-aminobutyric acid type A receptor alpha2 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family.


ensembl_gene_id: ENSLOCP00000015252
symbol: KATNAL2
gene_biotype: protein_coding
description:
  Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.


ensembl_gene_id: ENSLOCP00000015255
symbol: gabrg1
gene_biotype: protein_coding
description:
  Gamma-aminobutyric acid type A receptor gamma1 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family.


ensembl_gene_id: ENSLOCP00000015269
symbol: GUF1
gene_biotype: protein_coding
description:
  Translation factor GUF1, mitochondrial; Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.


ensembl_gene_id: ENSLOCP00000015288
symbol: LOC102684798
gene_biotype: protein_coding
description:
  Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.


ensembl_gene_id: ENSLOCP00000015303
symbol: tubg1
gene_biotype: protein_coding
description:
  Tubulin gamma chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome.


ensembl_gene_id: ENSLOCP00000015356
symbol: W5N3Z7_LEPOC
gene_biotype: protein_coding
description:
  Hydroxysteroid (17-beta) dehydrogenase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family.


ensembl_gene_id: ENSLOCP00000015360
symbol: mat2b
gene_biotype: protein_coding
description:
  Methionine adenosyltransferase 2 subunit beta; Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine.


ensembl_gene_id: ENSLOCP00000015449
symbol: LOC102694859
gene_biotype: protein_coding
description:
  Coactivator-associated arginine methyltransferase 1, like; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.


ensembl_gene_id: ENSLOCP00000015466
symbol: fabp2
gene_biotype: protein_coding
description:
  Fatty acid binding protein 2, intestinal; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.


ensembl_gene_id: ENSLOCP00000015528
symbol: kdsr
gene_biotype: protein_coding
description:
  3-ketodihydrosphingosine reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family.


ensembl_gene_id: ENSLOCP00000015529
symbol: lzts2
gene_biotype: protein_coding
description:
  Leucine zipper putative tumor suppressor 2 homolog; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. Belongs to the LZTS2 family.


ensembl_gene_id: ENSLOCP00000015566
symbol: W5N4K7_LEPOC
gene_biotype: protein_coding
description:
  ATP-citrate synthase; In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.


ensembl_gene_id: ENSLOCP00000015575
symbol: med20
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 20; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.


ensembl_gene_id: ENSLOCP00000015586
symbol: adcy8
gene_biotype: protein_coding
description:
  Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.


ensembl_gene_id: ENSLOCP00000015613
symbol: AFMID
gene_biotype: protein_coding
description:
  Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.


ensembl_gene_id: ENSLOCP00000015630
symbol: kcnq3
gene_biotype: protein_coding
description:
  Potassium voltage-gated channel, KQT-like subfamily, member 3; Belongs to the potassium channel family.


ensembl_gene_id: ENSLOCP00000015636
symbol: rad51
gene_biotype: protein_coding
description:
  DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...]


ensembl_gene_id: ENSLOCP00000015650
symbol: W5N4U1_LEPOC
gene_biotype: protein_coding
description:
  Post-GPI attachment to proteins factor 3; Involved in the lipid remodeling steps of GPI-anchor maturation; Belongs to the PGAP3 family.


ensembl_gene_id: ENSLOCP00000015677
symbol: nadk2
gene_biotype: protein_coding
description:
  NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.


ensembl_gene_id: ENSLOCP00000015680
symbol: adss1
gene_biotype: protein_coding
description:
  Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.


ensembl_gene_id: ENSLOCP00000015700
symbol: pgs1
gene_biotype: protein_coding
description:
  CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin; Belongs to the CDP-alcohol phosphatidyltransferase class-II family.


ensembl_gene_id: ENSLOCP00000015752
symbol: W5N543_LEPOC
gene_biotype: protein_coding
description:
  ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6; Belongs to the glycosyltransferase 29 family.


ensembl_gene_id: ENSLOCP00000015811
symbol: LOC102689111
gene_biotype: protein_coding
description:
  Glyoxylate reductase/hydroxypyruvate reductase b; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.


ensembl_gene_id: ENSLOCP00000015818
symbol: LOC102694674
gene_biotype: protein_coding
description:
  Glyoxylate reductase/hydroxypyruvate reductase a; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.


ensembl_gene_id: ENSLOCP00000015843
symbol: PLCB2
gene_biotype: protein_coding
description:
  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.


ensembl_gene_id: ENSLOCP00000015846
symbol: kif19
gene_biotype: protein_coding
description:
  Kinesin family member 19; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.


ensembl_gene_id: ENSLOCP00000015881
symbol: timm23
gene_biotype: protein_coding
description:
  Mitochondrial import inner membrane translocase subunit TIM23; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.


ensembl_gene_id: ENSLOCP00000015887
symbol: lsm5
gene_biotype: protein_coding
description:
  U6 snRNA-associated Sm-like protein LSm5; Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.


ensembl_gene_id: ENSLOCP00000015908
symbol: kif26a
gene_biotype: protein_coding
description:
  Kinesin family member 26Aa; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.


ensembl_gene_id: ENSLOCP00000015959
symbol: NSUN7
gene_biotype: protein_coding
description:
  NOP2/Sun RNA methyltransferase family member 7; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.


ensembl_gene_id: ENSLOCP00000015960
symbol: W5N5Q1_LEPOC
gene_biotype: protein_coding
description:
  GDNF family receptor alpha-1; Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. Belongs to the GDNFR family.


ensembl_gene_id: ENSLOCP00000015984
symbol: serpina10
gene_biotype: protein_coding
description:
  Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10a; Belongs to the serpin family.


ensembl_gene_id: ENSLOCP00000015998
symbol: ube2k
gene_biotype: protein_coding
description:
  Ubiquitin-conjugating enzyme E2Kb (UBC1 homolog, yeast); Belongs to the ubiquitin-conjugating enzyme family.


ensembl_gene_id: ENSLOCP00000016013
symbol: LIAS
gene_biotype: protein_coding
description:
  Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.


ensembl_gene_id: ENSLOCP00000016016
symbol: W5N5V7_LEPOC
gene_biotype: protein_coding
description:
  Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family.


ensembl_gene_id: ENSLOCP00000016112
symbol: mcm7
gene_biotype: protein_coding
description:
  DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]


ensembl_gene_id: ENSLOCP00000016117
symbol: exoc7
gene_biotype: protein_coding
description:
  Exocyst complex component 7; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.


ensembl_gene_id: ENSLOCP00000016126
symbol: ap4m1
gene_biotype: protein_coding
description:
  AP-4 complex subunit mu-1; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asym [...]


ensembl_gene_id: ENSLOCP00000016136
symbol: adcy1
gene_biotype: protein_coding
description:
  Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.


ensembl_gene_id: ENSLOCP00000016140
symbol: bloc1s6
gene_biotype: protein_coding
description:
  Biogenesis of lysosome-related organelles complex 1 subunit 6; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particular [...]


ensembl_gene_id: ENSLOCP00000016176
symbol: elovl2
gene_biotype: protein_coding
description:
  Elongation of very long chain fatty acids protein 2; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). May participate to the production  [...]


ensembl_gene_id: ENSLOCP00000016196
symbol: med11
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 11; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.


ensembl_gene_id: ENSLOCP00000016197
symbol: LOC102695473
gene_biotype: protein_coding
description:
  Protoheme IX farnesyltransferase, mitochondrial; Converts protoheme IX and farnesyl diphosphate to heme O. Belongs to the ubiA prenyltransferase family.


ensembl_gene_id: ENSLOCP00000016252
symbol: gtf2e2
gene_biotype: protein_coding
description:
  Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.


ensembl_gene_id: ENSLOCP00000016253
symbol: pdhb
gene_biotype: protein_coding
description:
  Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.


ensembl_gene_id: ENSLOCP00000016294
symbol: bloc1s5
gene_biotype: protein_coding
description:
  Biogenesis of lysosome-related organelles complex 1 subunit 5; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO).


ensembl_gene_id: ENSLOCP00000016298
symbol: myh10
gene_biotype: protein_coding
description:
  Myosin, heavy chain 10, non-muscle; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.


ensembl_gene_id: ENSLOCP00000016329
symbol: slc24a5
gene_biotype: protein_coding
description:
  Solute carrier family 24 member 5; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.


ensembl_gene_id: ENSLOCP00000016331
symbol: pigm
gene_biotype: protein_coding
description:
  GPI mannosyltransferase 1; Mannosyltransferase involved in glycosylphosphatidylinositol- anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN- acyl-PI during GPI precursor assembly.


ensembl_gene_id: ENSLOCP00000016349
symbol: sema6d
gene_biotype: protein_coding
description:
  Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D, like; Belongs to the semaphorin family.


ensembl_gene_id: ENSLOCP00000016359
symbol: LOC102696624
gene_biotype: protein_coding
description:
  Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.


ensembl_gene_id: ENSLOCP00000016414
symbol: W5N705_LEPOC
gene_biotype: protein_coding
description:
  AP-4 complex subunit epsilon; AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system; Belongs to the adaptor complexes large subunit family.


ensembl_gene_id: ENSLOCP00000016468
symbol: psen1
gene_biotype: protein_coding
description:
  Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.


ensembl_gene_id: ENSLOCP00000016483
symbol: LOC102697629
gene_biotype: protein_coding
description:
  Septin 9a; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.


ensembl_gene_id: ENSLOCP00000016557
symbol: mtap
gene_biotype: protein_coding
description:
  S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.


ensembl_gene_id: ENSLOCP00000016636
symbol: snf8
gene_biotype: protein_coding
description:
  Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family.


ensembl_gene_id: ENSLOCP00000016675
symbol: srp68
gene_biotype: protein_coding
description:
  Signal recognition particle subunit SRP68; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane; Belongs to the SRP68 family.


ensembl_gene_id: ENSLOCP00000016685
symbol: W5N7S6_LEPOC
gene_biotype: protein_coding
description:
  SEC13 homolog, nuclear pore and COPII coat complex component; Belongs to the WD repeat SEC13 family.


ensembl_gene_id: ENSLOCP00000016700
symbol: cdc6
gene_biotype: protein_coding
description:
  Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.


ensembl_gene_id: ENSLOCP00000016717
symbol: lsm3
gene_biotype: protein_coding
description:
  U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA.


ensembl_gene_id: ENSLOCP00000016767
symbol: hpgd
gene_biotype: protein_coding
description:
  15-hydroxyprostaglandin dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family.


ensembl_gene_id: ENSLOCP00000016802
symbol: cacng1
gene_biotype: protein_coding
description:
  Voltage-dependent calcium channel gamma-1 subunit; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics.


ensembl_gene_id: ENSLOCP00000016806
symbol: cacng4
gene_biotype: protein_coding
description:
  Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.


ensembl_gene_id: ENSLOCP00000016830
symbol: LOC102693600
gene_biotype: protein_coding
description:
  ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 7.1; Belongs to the glycosyltransferase 29 family.


ensembl_gene_id: ENSLOCP00000016859
symbol: W5N8A0_LEPOC
gene_biotype: protein_coding
description:
  Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family.


ensembl_gene_id: ENSLOCP00000016872
symbol: mphosph10
gene_biotype: protein_coding
description:
  U3 small nucleolar ribonucleoprotein protein MPP10; Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing; Belongs to the MPP10 family.


ensembl_gene_id: ENSLOCP00000016899
symbol: KIF1C
gene_biotype: protein_coding
description:
  Kinesin family member 1C; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.


ensembl_gene_id: ENSLOCP00000016926
symbol: LOC102687756
gene_biotype: protein_coding
description:
  10-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.


ensembl_gene_id: ENSLOCP00000016940
symbol: rhbdl3
gene_biotype: protein_coding
description:
  Rhomboid-related protein 3; May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors; Belongs to the peptidase S54 family.


ensembl_gene_id: ENSLOCP00000016966
symbol: LOC102690809
gene_biotype: protein_coding
description:
  Gamma-aminobutyric acid type A receptor beta4 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family.


ensembl_gene_id: ENSLOCP00000016975
symbol: LOC102697743
gene_biotype: protein_coding
description:
  Gamma-aminobutyric acid (GABA) A receptor, alpha 3; Belongs to the ligand-gated ion channel (TC 1.A.9) family.


ensembl_gene_id: ENSLOCP00000016978
symbol: eif3j
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 3 subunit J; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.


ensembl_gene_id: ENSLOCP00000017040
symbol: slc24a1
gene_biotype: protein_coding
description:
  Solute carrier family 24 member 1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.


ensembl_gene_id: ENSLOCP00000017051
symbol: SLC2A4
gene_biotype: protein_coding
description:
  Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.


ensembl_gene_id: ENSLOCP00000017056
symbol: kif4a
gene_biotype: protein_coding
description:
  Kinesin family member 4; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.


ensembl_gene_id: ENSLOCP00000017064
symbol: ippk
gene_biotype: protein_coding
description:
  Inositol-pentakisphosphate 2-kinase; Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).


ensembl_gene_id: ENSLOCP00000017108
symbol: gaa
gene_biotype: protein_coding
description:
  Glucosidase, alpha; acid (Pompe disease, glycogen storage disease type II); Belongs to the glycosyl hydrolase 31 family.


ensembl_gene_id: ENSLOCP00000017164
symbol: atg7
gene_biotype: protein_coding
description:
  Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]


ensembl_gene_id: ENSLOCP00000017181
symbol: tamm41
gene_biotype: protein_coding
description:
  Phosphatidate cytidylyltransferase, mitochondrial; Catalyzes the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA) in the mitochondrial inner membrane. Required for the biosynthesis of the dimeric phospholipid cardiolipin, which stabilizes supercomplexes of the mitochondrial respiratory chain in the mitochondrial inner membrane.


ensembl_gene_id: ENSLOCP00000017201
symbol: PPARG
gene_biotype: protein_coding
description:
  Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]


ensembl_gene_id: ENSLOCP00000017207
symbol: tsen2
gene_biotype: protein_coding
description:
  tRNA-splicing endonuclease subunit Sen2; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural [...]


ensembl_gene_id: ENSLOCP00000017218
symbol: rsad1
gene_biotype: protein_coding
description:
  Radical S-adenosyl methionine domain-containing protein; May be a heme chaperone, appears to bind heme. Homologous bacterial proteins do not have oxygen-independent coproporphyrinogen- III oxidase activity. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L- methionine; Belongs to the anaerobic coproporphyrinogen-III oxidase family.


ensembl_gene_id: ENSLOCP00000017253
symbol: fis1
gene_biotype: protein_coding
description:
  Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering.


ensembl_gene_id: ENSLOCP00000017267
symbol: W5N9F8_LEPOC
gene_biotype: protein_coding
description:
  Amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.


ensembl_gene_id: ENSLOCP00000017304
symbol: med6
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 6; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.


ensembl_gene_id: ENSLOCP00000017316
symbol: slc8a3
gene_biotype: protein_coding
description:
  Solute carrier family 8 member 3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.


ensembl_gene_id: ENSLOCP00000017319
symbol: serpine1
gene_biotype: protein_coding
description:
  Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Belongs to the serpin family.


ensembl_gene_id: ENSLOCP00000017334
symbol: anapc4
gene_biotype: protein_coding
description:
  Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family.


ensembl_gene_id: ENSLOCP00000017385
symbol: slc24a4
gene_biotype: protein_coding
description:
  Solute carrier family 24 member 4a; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.


ensembl_gene_id: ENSLOCP00000017409
symbol: fut8
gene_biotype: protein_coding
description:
  Alpha-(1,6)-fucosyltransferase; Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. Belongs to the glycosyltransferase 23 family.


ensembl_gene_id: ENSLOCP00000017444
symbol: actr8
gene_biotype: protein_coding
description:
  Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily.


ensembl_gene_id: ENSLOCP00000017446
symbol: W5N9Y7_LEPOC
gene_biotype: protein_coding
description:
  Platelet-derived growth factor receptor, alpha polypeptide; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.


ensembl_gene_id: ENSLOCP00000017458
symbol: kit
gene_biotype: protein_coding
description:
  Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.


ensembl_gene_id: ENSLOCP00000017466
symbol: nop53
gene_biotype: protein_coding
description:
  Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family.


ensembl_gene_id: ENSLOCP00000017473
symbol: kdr
gene_biotype: protein_coding
description:
  Kinase insert domain receptor (a type III receptor tyrosine kinase); Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.


ensembl_gene_id: ENSLOCP00000017478
symbol: W5NA19_LEPOC
gene_biotype: protein_coding
description:
  Inositol-tetrakisphosphate 1-kinase; Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Belongs to the ITPK1 family.


ensembl_gene_id: ENSLOCP00000017494
symbol: W5NA35_LEPOC
gene_biotype: protein_coding
description:
  EH-domain containing 2a; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.


ensembl_gene_id: ENSLOCP00000017509
symbol: bckdha
gene_biotype: protein_coding
description:
  2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).


ensembl_gene_id: ENSLOCP00000017531
symbol: zmynd10
gene_biotype: protein_coding
description:
  Zinc finger MYND domain-containing protein 10; Plays a role in axonemal structure organization and motility. Involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility. May act by indirectly regulating transcription of dynein proteins. Belongs to the ZMYND10 family.


ensembl_gene_id: ENSLOCP00000017573
symbol: g6pd
gene_biotype: protein_coding
description:
  Glucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.


ensembl_gene_id: ENSLOCP00000017606
symbol: W5NAE7_LEPOC
gene_biotype: protein_coding
description:
  Transient receptor potential cation channel, subfamily C, member 5a; Belongs to the transient receptor (TC 1.A.4) family.


ensembl_gene_id: ENSLOCP00000017635
symbol: LOC102698824
gene_biotype: protein_coding
description:
  Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3bl; Belongs to the semaphorin family.


ensembl_gene_id: ENSLOCP00000017654
symbol: eif3k
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 3 subunit K; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.


ensembl_gene_id: ENSLOCP00000017657
symbol: W5NAJ8_LEPOC
gene_biotype: protein_coding
description:
  Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B; Belongs to the semaphorin family.


ensembl_gene_id: ENSLOCP00000017663
symbol: W5NAK4_LEPOC
gene_biotype: protein_coding
description:
  Mitogen-activated protein kinase kinase kinase kinase 1; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.


ensembl_gene_id: ENSLOCP00000017705
symbol: st8sia2
gene_biotype: protein_coding
description:
  ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2; Belongs to the glycosyltransferase 29 family.


ensembl_gene_id: ENSLOCP00000017723
symbol: IMPDH
gene_biotype: protein_coding
description:
  Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.


ensembl_gene_id: ENSLOCP00000017731
symbol: W5NAS2_LEPOC
gene_biotype: protein_coding
description:
  Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family.


ensembl_gene_id: ENSLOCP00000017751
symbol: W5NAU2_LEPOC
gene_biotype: protein_coding
description:
  Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.


ensembl_gene_id: ENSLOCP00000017774
symbol: W5NAW5_LEPOC
gene_biotype: protein_coding
description:
  Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Ga; Belongs to the semaphorin family.


ensembl_gene_id: ENSLOCP00000017811
symbol: apex2
gene_biotype: protein_coding
description:
  DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.


ensembl_gene_id: ENSLOCP00000017813
symbol: prkcd
gene_biotype: protein_coding
description:
  Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.


ensembl_gene_id: ENSLOCP00000017815
symbol: tnk1
gene_biotype: protein_coding
description:
  Tyrosine kinase, non-receptor, 1; Belongs to the protein kinase superfamily. Tyr protein kinase family.


ensembl_gene_id: ENSLOCP00000017818
symbol: W5NB09_LEPOC
gene_biotype: protein_coding
description:
  Protein RFT1 homolog; May be involved in N-linked oligosaccharide assembly. Belongs to the RFT1 family.


ensembl_gene_id: ENSLOCP00000017877
symbol: kcnd1
gene_biotype: protein_coding
description:
  Potassium voltage-gated channel, Shal-related subfamily, member 1; Belongs to the potassium channel family.


ensembl_gene_id: ENSLOCP00000017882
symbol: W5NB73_LEPOC
gene_biotype: protein_coding
description:
  Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family.


ensembl_gene_id: ENSLOCP00000017900
symbol: W5NB91_LEPOC
gene_biotype: protein_coding
description:
  Kinesin family member 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.


ensembl_gene_id: ENSLOCP00000017901
symbol: W5NB92_LEPOC
gene_biotype: protein_coding
description:
  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...]


ensembl_gene_id: ENSLOCP00000017908
symbol: hmces
gene_biotype: protein_coding
description:
  Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...]


ensembl_gene_id: ENSLOCP00000018019
symbol: wdr76
gene_biotype: protein_coding
description:
  WD repeat-containing protein 76; Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. Belongs to the WD repeat DDB2/WDR76 family.


ensembl_gene_id: ENSLOCP00000018053
symbol: slc28a1
gene_biotype: protein_coding
description:
  Sodium/nucleoside cotransporter; Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.


ensembl_gene_id: ENSLOCP00000018097
symbol: timm50
gene_biotype: protein_coding
description:
  Mitochondrial import inner membrane translocase subunit TIM50; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.


ensembl_gene_id: ENSLOCP00000018157
symbol: vma21
gene_biotype: protein_coding
description:
  Vacuolar ATPase assembly integral membrane protein VMA21; Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum; Belongs to the VMA21 family.


ensembl_gene_id: ENSLOCP00000018170
symbol: W5NC11_LEPOC
gene_biotype: protein_coding
description:
  Pseudouridine synthase; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family.


ensembl_gene_id: ENSLOCP00000018218
symbol: W5NC59_LEPOC
gene_biotype: protein_coding
description:
  Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family.


ensembl_gene_id: ENSLOCP00000018356
symbol: gfra2
gene_biotype: protein_coding
description:
  GDNF family receptor alpha-2; Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor.


ensembl_gene_id: ENSLOCP00000018376
symbol: vbp1
gene_biotype: protein_coding
description:
  Prefoldin subunit 3; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins; Belongs to the prefoldin subunit alpha family.


ensembl_gene_id: ENSLOCP00000018379
symbol: W5NCM0_LEPOC
gene_biotype: protein_coding
description:
  Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]


ensembl_gene_id: ENSLOCP00000018522
symbol: crabp1
gene_biotype: protein_coding
description:
  Cellular retinoic acid binding protein 1b; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.


ensembl_gene_id: ENSLOCP00000018642
symbol: lsm1
gene_biotype: protein_coding
description:
  U6 snRNA-associated Sm-like protein LSm1; Probably involved with other LSm subunits in the general process of degradation of mRNAs.


ensembl_gene_id: ENSLOCP00000018656
symbol: apaf1
gene_biotype: protein_coding
description:
  Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.


ensembl_gene_id: ENSLOCP00000018657
symbol: star
gene_biotype: protein_coding
description:
  Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.


ensembl_gene_id: ENSLOCP00000018711
symbol: ciao1
gene_biotype: protein_coding
description:
  Probable cytosolic iron-sulfur protein assembly protein CIAO1; Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Belongs to the WD repeat CIA1 family.


ensembl_gene_id: ENSLOCP00000018726
symbol: W5NDL7_LEPOC
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.


ensembl_gene_id: ENSLOCP00000018728
symbol: W5NDL9_LEPOC
gene_biotype: protein_coding
description:
  Kinase insert domain receptor like; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.


ensembl_gene_id: ENSLOCP00000018742
symbol: ube2a
gene_biotype: protein_coding
description:
  Ubiquitin-conjugating enzyme E2A (RAD6 homolog); Belongs to the ubiquitin-conjugating enzyme family.


ensembl_gene_id: ENSLOCP00000018747
symbol: septin6
gene_biotype: protein_coding
description:
  Septin 6; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.


ensembl_gene_id: ENSLOCP00000018884
symbol: bcat1
gene_biotype: protein_coding
description:
  Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.


ensembl_gene_id: ENSLOCP00000018899
symbol: mars2
gene_biotype: protein_coding
description:
  Methionyl-tRNA synthetase 2, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family.


ensembl_gene_id: ENSLOCP00000018909
symbol: LOC102689238
gene_biotype: protein_coding
description:
  Condensin complex subunit 2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.


ensembl_gene_id: ENSLOCP00000018933
symbol: gys2
gene_biotype: protein_coding
description:
  Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan.


ensembl_gene_id: ENSLOCP00000019093
symbol: osgep
gene_biotype: protein_coding
description:
  Probable tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. OSGEP likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.


ensembl_gene_id: ENSLOCP00000019097
symbol: bgn
gene_biotype: protein_coding
description:
  Biglycan; May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.


ensembl_gene_id: ENSLOCP00000019119
symbol: hgf
gene_biotype: protein_coding
description:
  Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.


ensembl_gene_id: ENSLOCP00000019126
symbol: snd1
gene_biotype: protein_coding
description:
  Staphylococcal nuclease domain-containing protein; Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs.


ensembl_gene_id: ENSLOCP00000019166
symbol: LOC102697276
gene_biotype: protein_coding
description:
  Si:dkey-32e23.4; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.


ensembl_gene_id: ENSLOCP00000019173
symbol: atp6v1f
gene_biotype: protein_coding
description:
  V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.


ensembl_gene_id: ENSLOCP00000019181
symbol: lsm8
gene_biotype: protein_coding
description:
  U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.


ensembl_gene_id: ENSLOCP00000019187
symbol: W5NEX8_LEPOC
gene_biotype: protein_coding
description:
  Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.


ensembl_gene_id: ENSLOCP00000019223
symbol: copg2
gene_biotype: protein_coding
description:
  Coatomer subunit gamma; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.


ensembl_gene_id: ENSLOCP00000019231
symbol: polb
gene_biotype: protein_coding
description:
  DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.


ensembl_gene_id: ENSLOCP00000019251
symbol: pcna
gene_biotype: protein_coding
description:
  Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.


ensembl_gene_id: ENSLOCP00000019271
symbol: plpbp
gene_biotype: protein_coding
description:
  Pyridoxal phosphate homeostasis protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'- phosphate (PLP), the active form of vitamin B6; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.


ensembl_gene_id: ENSLOCP00000019298
symbol: AARS
gene_biotype: protein_coding
description:
  Alanyl-tRNA synthetase 2, mitochondrial (putative); Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.


ensembl_gene_id: ENSLOCP00000019313
symbol: ftsj1
gene_biotype: protein_coding
description:
  Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.


ensembl_gene_id: ENSLOCP00000019315
symbol: mgme1
gene_biotype: protein_coding
description:
  Mitochondrial genome maintenance exonuclease 1; Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair. Belongs to the MGME1 family.


ensembl_gene_id: ENSLOCP00000019329
symbol: polr3f
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerase III subunit RPC6; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs; Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.


ensembl_gene_id: ENSLOCP00000019344
symbol: cdc123
gene_biotype: protein_coding
description:
  Cell division cycle protein 123 homolog; Required for S phase entry of the cell cycle. Belongs to the CDC123 family.


ensembl_gene_id: ENSLOCP00000019346
symbol: W5NFD7_LEPOC
gene_biotype: protein_coding
description:
  Epoxide hydrolase; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Belongs to the peptidase S33 family.


ensembl_gene_id: ENSLOCP00000019367
symbol: W5NFF8_LEPOC
gene_biotype: protein_coding
description:
  Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]


ensembl_gene_id: ENSLOCP00000019381
symbol: slc8a1
gene_biotype: protein_coding
description:
  Solute carrier family 8 member 1b; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.


ensembl_gene_id: ENSLOCP00000019388
symbol: metap2
gene_biotype: protein_coding
description:
  Methionine aminopeptidase 2; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.


ensembl_gene_id: ENSLOCP00000019401
symbol: W5NFJ2_LEPOC
gene_biotype: protein_coding
description:
  Mitogen-activated protein kinase kinase kinase kinase 3; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.


ensembl_gene_id: ENSLOCP00000019428
symbol: W5NFL9_LEPOC
gene_biotype: protein_coding
description:
  Kinesin family member 25; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.


ensembl_gene_id: ENSLOCP00000019438
symbol: kcnd2
gene_biotype: protein_coding
description:
  Potassium voltage-gated channel, Shal-related subfamily, member 2; Belongs to the potassium channel family.


ensembl_gene_id: ENSLOCP00000019452
symbol: parp1
gene_biotype: protein_coding
description:
  Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.


ensembl_gene_id: ENSLOCP00000019456
symbol: slc26a3
gene_biotype: protein_coding
description:
  Chloride anion exchanger; Chloride/bicarbonate exchanger. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.


ensembl_gene_id: ENSLOCP00000019464
symbol: LOC102688584
gene_biotype: protein_coding
description:
  Pendrin; Sodium-independent transporter of chloride and iodide. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.


ensembl_gene_id: ENSLOCP00000019470
symbol: dus4l
gene_biotype: protein_coding
description:
  tRNA-dihydrouridine synthase; Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs; Belongs to the dus family.


ensembl_gene_id: ENSLOCP00000019486
symbol: pik3cg
gene_biotype: protein_coding
description:
  Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma; Belongs to the PI3/PI4-kinase family.


ensembl_gene_id: ENSLOCP00000019501
symbol: scara5
gene_biotype: protein_coding
description:
  Scavenger receptor class A member 5; Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non- transferrin iron delivery pathways.


ensembl_gene_id: ENSLOCP00000019534
symbol: mpv17
gene_biotype: protein_coding
description:
  Mitochondrial inner membrane protein MPV17; Belongs to the peroxisomal membrane protein PXMP2/4 family.


ensembl_gene_id: ENSLOCP00000019583
symbol: srp9
gene_biotype: protein_coding
description:
  Signal recognition particle 9 kDa protein; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.


ensembl_gene_id: ENSLOCP00000019611
symbol: adcy3
gene_biotype: protein_coding
description:
  Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.


ensembl_gene_id: ENSLOCP00000019617
symbol: BMT2
gene_biotype: protein_coding
description:
  S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]


ensembl_gene_id: ENSLOCP00000019632
symbol: SPAST
gene_biotype: protein_coding
description:
  Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Go [...]


ensembl_gene_id: ENSLOCP00000019641
symbol: W5NG82_LEPOC
gene_biotype: protein_coding
description:
  GPN-loop GTPase; Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.


ensembl_gene_id: ENSLOCP00000019653
symbol: ube2h
gene_biotype: protein_coding
description:
  Ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast); Belongs to the ubiquitin-conjugating enzyme family.


ensembl_gene_id: ENSLOCP00000019667
symbol: elp3
gene_biotype: protein_coding
description:
  Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation.


ensembl_gene_id: ENSLOCP00000019688
symbol: kif16b
gene_biotype: protein_coding
description:
  Kinesin family member 16Ba; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.


ensembl_gene_id: ENSLOCP00000019694
symbol: W5NGD5_LEPOC
gene_biotype: protein_coding
description:
  Kinesin family member 13Ba; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.


ensembl_gene_id: ENSLOCP00000019707
symbol: PTPN12
gene_biotype: protein_coding
description:
  Tyrosine-protein phosphatase non-receptor type 12; Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades.


ensembl_gene_id: ENSLOCP00000019739
symbol: CDC42BPA
gene_biotype: protein_coding
description:
  Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.


ensembl_gene_id: ENSLOCP00000019743
symbol: sema3c
gene_biotype: protein_coding
description:
  Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C; Belongs to the semaphorin family.


ensembl_gene_id: ENSLOCP00000019749
symbol: actr2
gene_biotype: protein_coding
description:
  Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.


ensembl_gene_id: ENSLOCP00000019821
symbol: gins4
gene_biotype: protein_coding
description:
  DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family.


ensembl_gene_id: ENSLOCP00000019830
symbol: kif21a
gene_biotype: protein_coding
description:
  Kinesin family member 21A; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.


ensembl_gene_id: ENSLOCP00000019836
symbol: slc2a13
gene_biotype: protein_coding
description:
  Solute carrier family 2 member 13b; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.


ensembl_gene_id: ENSLOCP00000019914
symbol: slc24a3
gene_biotype: protein_coding
description:
  Solute carrier family 24 member 3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.


ensembl_gene_id: ENSLOCP00000019939
symbol: kcnq5
gene_biotype: protein_coding
description:
  Potassium voltage-gated channel, KQT-like subfamily, member 5b; Belongs to the potassium channel family.


ensembl_gene_id: ENSLOCP00000019955
symbol: sod2
gene_biotype: protein_coding
description:
  Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.


ensembl_gene_id: ENSLOCP00000019965
symbol: eif3l
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 3 subunit L; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.


ensembl_gene_id: ENSLOCP00000020010
symbol: slc2a12
gene_biotype: protein_coding
description:
  Solute carrier family 2 member 12; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.


ensembl_gene_id: ENSLOCP00000020044
symbol: kcnc2
gene_biotype: protein_coding
description:
  Potassium voltage-gated channel, Shaw-related subfamily, member 2; Belongs to the potassium channel family.


ensembl_gene_id: ENSLOCP00000020058
symbol: krr1
gene_biotype: protein_coding
description:
  KRR1 small subunit processome component; Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.


ensembl_gene_id: ENSLOCP00000020084
symbol: FSHR
gene_biotype: protein_coding
description:
  Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.


ensembl_gene_id: ENSLOCP00000020115
symbol: KCNK12
gene_biotype: protein_coding
description:
  Potassium two pore domain channel subfamily K member 12; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.


ensembl_gene_id: ENSLOCP00000020139
symbol: dnmt3a
gene_biotype: protein_coding
description:
  DNA (cytosine-5-)-methyltransferase 3 alpha b; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.


ensembl_gene_id: ENSLOCP00000020160
symbol: hadha
gene_biotype: protein_coding
description:
  Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha b; Belongs to the enoyl-CoA hydratase/isomerase family.


ensembl_gene_id: ENSLOCP00000020166
symbol: hadhb
gene_biotype: protein_coding
description:
  Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta; Belongs to the thiolase-like superfamily. Thiolase family.


ensembl_gene_id: ENSLOCP00000020247
symbol: sema3e
gene_biotype: protein_coding
description:
  Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E; Belongs to the semaphorin family.


ensembl_gene_id: ENSLOCP00000020254
symbol: RNF8
gene_biotype: protein_coding
description:
  E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]


ensembl_gene_id: ENSLOCP00000020255
symbol: sema3a
gene_biotype: protein_coding
description:
  Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Ab; Belongs to the semaphorin family.


ensembl_gene_id: ENSLOCP00000020258
symbol: sema3d
gene_biotype: protein_coding
description:
  Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D; Belongs to the semaphorin family.


ensembl_gene_id: ENSLOCP00000020318
symbol: haao
gene_biotype: protein_coding
description:
  3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate; Belongs to the 3-HAO family.


ensembl_gene_id: ENSLOCP00000020320
symbol: trmt6
gene_biotype: protein_coding
description:
  tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6; Substrate-binding subunit of tRNA (adenine-N1-)- methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.


ensembl_gene_id: ENSLOCP00000020388
symbol: prkn
gene_biotype: protein_coding
description:
  E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.


ensembl_gene_id: ENSLOCP00000020399
symbol: xpot
gene_biotype: protein_coding
description:
  Exportin-T; tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Belongs to the exportin family.


ensembl_gene_id: ENSLOCP00000020405
symbol: rtcb
gene_biotype: protein_coding
description:
  RNA-splicing ligase RtcB homolog; Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.


ensembl_gene_id: ENSLOCP00000020422
symbol: LHCGR
gene_biotype: protein_coding
description:
  Lutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.


ensembl_gene_id: ENSLOCP00000020480
symbol: kmo
gene_biotype: protein_coding
description:
  Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.


ensembl_gene_id: ENSLOCP00000020483
symbol: qrsl1
gene_biotype: protein_coding
description:
  Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Belongs to the amidase family. GatA subfamily.


ensembl_gene_id: ENSLOCP00000020527
symbol: W5NIR8_LEPOC
gene_biotype: protein_coding
description:
  Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.


ensembl_gene_id: ENSLOCP00000020566
symbol: kif26b
gene_biotype: protein_coding
description:
  Kinesin family member 26Ba; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.


ensembl_gene_id: ENSLOCP00000020577
symbol: galnt8
gene_biotype: protein_coding
description:
  Ricin B-type lectin domain-containing protein; Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.


ensembl_gene_id: ENSLOCP00000020591
symbol: W5NIY2_LEPOC
gene_biotype: protein_coding
description:
  Rho-associated, coiled-coil containing protein kinase 2b; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.


ensembl_gene_id: ENSLOCP00000020605
symbol: LOC102694194
gene_biotype: protein_coding
description:
  Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.


ensembl_gene_id: ENSLOCP00000020637
symbol: PTPN14
gene_biotype: protein_coding
description:
  Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily.


ensembl_gene_id: ENSLOCP00000020677
symbol: W5NJ68_LEPOC
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 2B, subunit 4 delta; Belongs to the eIF-2B alpha/beta/delta subunits family.


ensembl_gene_id: ENSLOCP00000020691
symbol: dnph1
gene_biotype: protein_coding
description:
  2'-deoxynucleoside 5'-phosphate N-hydrolase 1; Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'-monophosphates containing purine bases are preferred to those containing pyrimidine bases.


ensembl_gene_id: ENSLOCP00000020701
symbol: cpt1b
gene_biotype: protein_coding
description:
  Carnitine palmitoyltransferase 1B (muscle); Belongs to the carnitine/choline acetyltransferase family.


ensembl_gene_id: ENSLOCP00000020731
symbol: tymp
gene_biotype: protein_coding
description:
  Thymidine phosphorylase; Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.


ensembl_gene_id: ENSLOCP00000020749
symbol: LOC102697528
gene_biotype: protein_coding
description:
  EH-domain containing 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.


ensembl_gene_id: ENSLOCP00000020782
symbol: W5NJH3_LEPOC
gene_biotype: protein_coding
description:
  Membrane bound O-acyltransferase domain containing 2a; Belongs to the membrane-bound acyltransferase family.


ensembl_gene_id: ENSLOCP00000020804
symbol: ywhaq
gene_biotype: protein_coding
description:
  Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide a; Belongs to the 14-3-3 family.


ensembl_gene_id: ENSLOCP00000020823
symbol: LOC102692415
gene_biotype: protein_coding
description:
  Protein arginine methyltransferase 8b; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.


ensembl_gene_id: ENSLOCP00000020844
symbol: MOCS3
gene_biotype: protein_coding
description:
  Adenylyltransferase and sulfurtransferase MOCS3; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl- adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (- COSH) of their C-terminus. The reaction probably involves hydrogen sulfide [...]


ensembl_gene_id: ENSLOCP00000020848
symbol: ndufaf7
gene_biotype: protein_coding
description:
  Protein arginine methyltransferase NDUFAF7; Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).


ensembl_gene_id: ENSLOCP00000020863
symbol: xrn2
gene_biotype: protein_coding
description:
  5'-3' exoribonuclease; Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.


ensembl_gene_id: ENSLOCP00000020873
symbol: elovl5
gene_biotype: protein_coding
description:
  Elongation of very long chain fatty acids protein 5; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involv [...]


ensembl_gene_id: ENSLOCP00000020927
symbol: RARS2
gene_biotype: protein_coding
description:
  Arginyl-tRNA synthetase 2, mitochondrial (putative); Belongs to the class-I aminoacyl-tRNA synthetase family.


ensembl_gene_id: ENSLOCP00000020934
symbol: rngtt
gene_biotype: protein_coding
description:
  Polynucleotide 5'-triphosphatase; Bifunctional mRNA-capping enzyme exhibiting RNA 5'- triphosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the gmp moiety of GTP to the 5'-diphosphate terminus.


ensembl_gene_id: ENSLOCP00000020942
symbol: LOC102689509
gene_biotype: protein_coding
description:
  Gamma-aminobutyric acid (GABA) A receptor, rho 2a; Belongs to the ligand-gated ion channel (TC 1.A.9) family.


ensembl_gene_id: ENSLOCP00000020985
symbol: HDAC2
gene_biotype: protein_coding
description:
  Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.


ensembl_gene_id: ENSLOCP00000020992
symbol: avpr1a
gene_biotype: protein_coding
description:
  Arginine vasopressin receptor 1Ab; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.


ensembl_gene_id: ENSLOCP00000021016
symbol: ppil4
gene_biotype: protein_coding
description:
  Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.


ensembl_gene_id: ENSLOCP00000021018
symbol: KATNA1
gene_biotype: protein_coding
description:
  Katanin p60 ATPase-containing subunit A1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.


ensembl_gene_id: ENSLOCP00000021029
symbol: prim2
gene_biotype: protein_coding
description:
  DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands.


ensembl_gene_id: ENSLOCP00000021034
symbol: fbln1
gene_biotype: protein_coding
description:
  Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes.


ensembl_gene_id: ENSLOCP00000021065
symbol: GLO1
gene_biotype: protein_coding
description:
  Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.


ensembl_gene_id: ENSLOCP00000021081
symbol: elovl4
gene_biotype: protein_coding
description:
  Elongation of very long chain fatty acids protein 4; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane  [...]


ensembl_gene_id: ENSLOCP00000021090
symbol: ntf3
gene_biotype: protein_coding
description:
  Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family.


ensembl_gene_id: ENSLOCP00000021098
symbol: pgm3
gene_biotype: protein_coding
description:
  Phosphoacetylglucosamine mutase; Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O- glycosylation; Belongs to the phosphohexose mutase family.


ensembl_gene_id: ENSLOCP00000021126
symbol: coq3
gene_biotype: protein_coding
description:
  Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.


ensembl_gene_id: ENSLOCP00000021225
symbol: nosip
gene_biotype: protein_coding
description:
  Nitric oxide synthase-interacting protein; Negatively regulates nitric oxide production by inducing nitric oxide synthase translocation to actin cytoskeleton and inhibiting its enzymatic activity; Belongs to the NOSIP family.


ensembl_gene_id: ENSLOCP00000021229
symbol: KCNK16
gene_biotype: protein_coding
description:
  Potassium two pore domain channel subfamily K member 16; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.


ensembl_gene_id: ENSLOCP00000021230
symbol: LOC102684248
gene_biotype: protein_coding
description:
  Potassium channel, subfamily K, member 17; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.


ensembl_gene_id: ENSLOCP00000021231
symbol: kcnk5
gene_biotype: protein_coding
description:
  Potassium channel, subfamily K, member 5a; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.


ensembl_gene_id: ENSLOCP00000021244
symbol: W5NKT5_LEPOC
gene_biotype: protein_coding
description:
  Potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3a; Belongs to the potassium channel family.


ensembl_gene_id: ENSLOCP00000021281
symbol: adi1
gene_biotype: protein_coding
description:
  1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Belongs to the acireductone dioxygenase (ARD) family.


ensembl_gene_id: ENSLOCP00000021325
symbol: ptk2b
gene_biotype: protein_coding
description:
  Protein tyrosine kinase 2 beta, b; Belongs to the protein kinase superfamily. Tyr protein kinase family.


ensembl_gene_id: ENSLOCP00000021340
symbol: hsdl1
gene_biotype: protein_coding
description:
  Hydroxysteroid dehydrogenase like 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family.


ensembl_gene_id: ENSLOCP00000021345
symbol: fabp7
gene_biotype: protein_coding
description:
  Fatty acid binding protein 7, brain, a; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.


ensembl_gene_id: ENSLOCP00000021402
symbol: LOC102691582
gene_biotype: protein_coding
description:
  Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide; Belongs to the 14-3-3 family.


ensembl_gene_id: ENSLOCP00000021429
symbol: W5NLC0_LEPOC
gene_biotype: protein_coding
description:
  Brain-derived neurotrophic factor; Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it; Belongs to the NGF-beta family.


ensembl_gene_id: ENSLOCP00000021529
symbol: pigw
gene_biotype: protein_coding
description:
  Phosphatidylinositol-glycan biosynthesis class W protein; Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.


ensembl_gene_id: ENSLOCP00000021542
symbol: W5NLN3_LEPOC
gene_biotype: protein_coding
description:
  Uncharacterized protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Belongs to the connexin family.


ensembl_gene_id: ENSLOCP00000021544
symbol: dusp14
gene_biotype: protein_coding
description:
  Dual specificity phosphatase 14; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.


ensembl_gene_id: ENSLOCP00000021630
symbol: f2rl2
gene_biotype: protein_coding
description:
  Coagulation factor II (thrombin) receptor-like 2; Belongs to the G-protein coupled receptor 1 family.


ensembl_gene_id: ENSLOCP00000021636
symbol: W5NLX7_LEPOC
gene_biotype: protein_coding
description:
  Heat shock protein, alpha-crystallin-related, b3; Belongs to the small heat shock protein (HSP20) family.


ensembl_gene_id: ENSLOCP00000021658
symbol: pop7
gene_biotype: protein_coding
description:
  Ribonuclease P protein subunit p20; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.


ensembl_gene_id: ENSLOCP00000021766
symbol: W5NMA7_LEPOC
gene_biotype: protein_coding
description:
  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the [...]


ensembl_gene_id: ENSLOCP00000021784
symbol: dpm3
gene_biotype: protein_coding
description:
  Dolichol-phosphate mannosyltransferase subunit 3; Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER. Belongs to the DPM3 family.


ensembl_gene_id: ENSLOCP00000021845
symbol: LOC102699233
gene_biotype: protein_coding
description:
  Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.


ensembl_gene_id: ENSLOCP00000021847
symbol: prmt6
gene_biotype: protein_coding
description:
  Protein arginine methyltransferase 6; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.


ensembl_gene_id: ENSLOCP00000021916
symbol: rrs1
gene_biotype: protein_coding
description:
  Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family.


ensembl_gene_id: ENSLOCP00000022012
symbol: kcna1
gene_biotype: protein_coding
description:
  Potassium voltage-gated channel, shaker-related subfamily, member 1b; Belongs to the potassium channel family.


ensembl_gene_id: ENSLOCP00000022114
symbol: cnr1
gene_biotype: protein_coding
description:
  Cannabinoid receptor; Involved in cannabinoid-induced CNS effects. Belongs to the G-protein coupled receptor 1 family.


ensembl_gene_id: ENSLOCP00000022170
symbol: LOC102692330
gene_biotype: protein_coding
description:
  Potassium voltage-gated channel, shaker-related subfamily, member 2a; Belongs to the potassium channel family.


ensembl_gene_id: ENSLOCP00000022257
symbol: W5NNP8_LEPOC
gene_biotype: protein_coding
description:
  Zgc:153044; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.


ensembl_gene_id: ENSLOCP00000022404
symbol: med7
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 7; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery.


ensembl_gene_id: ENSLOCP00000022442
symbol: KCNS2
gene_biotype: protein_coding
description:
  Potassium voltage-gated channel modifier subfamily S member 2; Belongs to the potassium channel family.


ensembl_gene_id: ENSLOCP00000022472
symbol: ND2
gene_biotype: protein_coding
description:
  NADH-ubiquinone oxidoreductase chain 2; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.


ensembl_gene_id: ENSLOCP00000022473
symbol: COX1
gene_biotype: protein_coding
description:
  Cytochrome c oxidase subunit 1; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...]


ensembl_gene_id: ENSLOCP00000022474
symbol: COX2
gene_biotype: protein_coding
description:
  Cytochrome c oxidase subunit 2; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...]


ensembl_gene_id: ENSLOCP00000022477
symbol: COX3
gene_biotype: protein_coding
description:
  Cytochrome c oxidase subunit 3; Subunits I, II and III form the functional core of the enzyme complex.


ensembl_gene_id: ENSLOCP00000022478
symbol: ND3
gene_biotype: protein_coding
description:
  NADH-ubiquinone oxidoreductase chain 3; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.


ensembl_gene_id: ENSLOCP00000022479
symbol: ND4L
gene_biotype: protein_coding
description:
  NADH-ubiquinone oxidoreductase chain 4L; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.


ensembl_gene_id: ENSLOCP00000022480
symbol: ND4
gene_biotype: protein_coding
description:
  NADH-ubiquinone oxidoreductase chain 4; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.


ensembl_gene_id: ENSLOCP00000022481
symbol: ND5
gene_biotype: protein_coding
description:
  NADH-ubiquinone oxidoreductase chain 5; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.


ensembl_gene_id: ENSLOCP00000022482
symbol: ND6
gene_biotype: protein_coding
description:
  NADH-ubiquinone oxidoreductase chain 6; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.


ensembl_gene_id: ENSLOCP00000022483
symbol: CYTB
gene_biotype: protein_coding
description:
  Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.


