# geneInfo

ensembl_gene_id: A0A2U3UYC2
symbol: AK6
gene_biotype: protein_coding
description:
  Adenylate kinase isoenzyme 6; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation; Belongs to the adenylate kinase family. AK6 subfamily.


ensembl_gene_id: A0A2U3UYE3
symbol: COX2
gene_biotype: protein_coding
description:
  Cytochrome c oxidase subunit 2; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.


ensembl_gene_id: A0A2U3UYF0
symbol: ATP8
gene_biotype: protein_coding
description:
  ATP synthase protein 8; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subuni [...]


ensembl_gene_id: A0A2U3UYF1
symbol: ND5
gene_biotype: protein_coding
description:
  NADH-ubiquinone oxidoreductase chain 5; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.


ensembl_gene_id: A0A2U3UYF2
symbol: ND4
gene_biotype: protein_coding
description:
  NADH-ubiquinone oxidoreductase chain 4; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.


ensembl_gene_id: A0A2U3UYF3
symbol: COX3
gene_biotype: protein_coding
description:
  Cytochrome c oxidase subunit 3; Subunits I, II and III form the functional core of the enzyme complex.


ensembl_gene_id: A0A2U3UYF4
symbol: ND4L
gene_biotype: protein_coding
description:
  NADH-ubiquinone oxidoreductase chain 4L; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.


ensembl_gene_id: A0A2U3UYF7
symbol: ND6
gene_biotype: protein_coding
description:
  NADH-ubiquinone oxidoreductase chain 6; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.


ensembl_gene_id: A0A2U3UYF8
symbol: ND2
gene_biotype: protein_coding
description:
  NADH-ubiquinone oxidoreductase chain 2; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.


ensembl_gene_id: A0A2U3UYQ5
symbol: COX1
gene_biotype: protein_coding
description:
  Cytochrome c oxidase subunit 1; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.


ensembl_gene_id: A0A2U3UYR5
symbol: ND3
gene_biotype: protein_coding
description:
  NADH-ubiquinone oxidoreductase chain 3; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.


ensembl_gene_id: A0A2U3VAR6
symbol: ADH5
gene_biotype: protein_coding
description:
  S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.


ensembl_gene_id: A0A2U3VAR8
symbol: BMPR1B
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.


ensembl_gene_id: A0A2U3VAR9
symbol: METAP1
gene_biotype: protein_coding
description:
  Methionine aminopeptidase; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val).


ensembl_gene_id: A0A2U3VAS2
symbol: PDHA2
gene_biotype: protein_coding
description:
  Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).


ensembl_gene_id: A0A2U3VAX2
symbol: HSD17B11
gene_biotype: protein_coding
description:
  Estradiol 17-beta-dehydrogenase 11; Belongs to the short-chain dehydrogenases/reductases (SDR) family.


ensembl_gene_id: A0A2U3VAY5
symbol: COQ2
gene_biotype: protein_coding
description:
  4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.


ensembl_gene_id: A0A2U3VB01
symbol: ENOPH1
gene_biotype: protein_coding
description:
  Enolase-phosphatase E1; Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).


ensembl_gene_id: A0A2U3VB80
symbol: MINA
gene_biotype: protein_coding
description:
  Bifunctional lysine-specific demethylase and histidyl-hydroxylase; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase.


ensembl_gene_id: A0A2U3VB86
symbol: NSUN3
gene_biotype: protein_coding
description:
  Putative methyltransferase NSUN3; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.


ensembl_gene_id: A0A2U3VB93
symbol: MYH15
gene_biotype: protein_coding
description:
  LOW QUALITY PROTEIN: myosin-15; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.


ensembl_gene_id: A0A2U3VBA2
symbol: RRM1
gene_biotype: protein_coding
description:
  Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.


ensembl_gene_id: A0A2U3VBD5
symbol: CDS1
gene_biotype: protein_coding
description:
  Phosphatidate cytidylyltransferase; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin.


ensembl_gene_id: A0A2U3VBG1
symbol: LIPT2
gene_biotype: protein_coding
description:
  Putative lipoyltransferase 2, mitochondrial; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. Belongs to the LipB family.


ensembl_gene_id: A0A2U3VBH6
symbol: WNT11
gene_biotype: protein_coding
description:
  Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.


ensembl_gene_id: A0A2U3VBI9
symbol: AQP11
gene_biotype: protein_coding
description:
  Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.


ensembl_gene_id: A0A2U3VBK4
symbol: LOC101371734
gene_biotype: protein_coding
description:
  40S ribosomal protein SA; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteri [...]


ensembl_gene_id: A0A2U3VBL5
symbol: LOC101383141
gene_biotype: protein_coding
description:
  Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family.


ensembl_gene_id: A0A2U3VBM0
symbol: ATP13A4
gene_biotype: protein_coding
description:
  Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.


ensembl_gene_id: A0A2U3VBM9
symbol: BDH1
gene_biotype: protein_coding
description:
  D-beta-hydroxybutyrate dehydrogenase, mitochondrial; Belongs to the short-chain dehydrogenases/reductases (SDR) family.


ensembl_gene_id: A0A2U3VBP1
symbol: GABRR3
gene_biotype: protein_coding
description:
  Gamma-aminobutyric acid receptor subunit rho-3; Belongs to the ligand-gated ion channel (TC 1.A.9) family.


ensembl_gene_id: A0A2U3VBQ4
symbol: TNK2
gene_biotype: protein_coding
description:
  Activated CDC42 kinase 1 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family.


ensembl_gene_id: A0A2U3VBS5
symbol: LOC101386914
gene_biotype: protein_coding
description:
  LOW QUALITY PROTEIN: short transient receptor potential channel 2-like; Belongs to the transient receptor (TC 1.A.4) family.


ensembl_gene_id: A0A2U3VBT9
symbol: HACD2
gene_biotype: protein_coding
description:
  Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors  [...]


ensembl_gene_id: A0A2U3VBY5
symbol: ATP6V0E1
gene_biotype: protein_coding
description:
  V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.


ensembl_gene_id: A0A2U3VC05
symbol: GABRP
gene_biotype: protein_coding
description:
  Gamma-aminobutyric acid receptor subunit pi isoform X1; Belongs to the ligand-gated ion channel (TC 1.A.9) family.


ensembl_gene_id: A0A2U3VC31
symbol: GABRG2
gene_biotype: protein_coding
description:
  Gamma-aminobutyric acid receptor subunit gamma-2 isoform X1; Belongs to the ligand-gated ion channel (TC 1.A.9) family.


ensembl_gene_id: A0A2U3VC34
symbol: GABRA1
gene_biotype: protein_coding
description:
  Gamma-aminobutyric acid receptor subunit alpha-1; Belongs to the ligand-gated ion channel (TC 1.A.9) family.


ensembl_gene_id: A0A2U3VC35
symbol: GABRA6
gene_biotype: protein_coding
description:
  Gamma-aminobutyric acid receptor subunit alpha-6; Belongs to the ligand-gated ion channel (TC 1.A.9) family.


ensembl_gene_id: A0A2U3VC36
symbol: GABRB2
gene_biotype: protein_coding
description:
  Gamma-aminobutyric acid receptor subunit beta-2 isoform X1; Belongs to the ligand-gated ion channel (TC 1.A.9) family.


ensembl_gene_id: A0A2U3VC47
symbol: NCBP2
gene_biotype: protein_coding
description:
  Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...]


ensembl_gene_id: A0A2U3VC51
symbol: DYNLRB2
gene_biotype: protein_coding
description:
  Dynein light chain roadblock; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.


ensembl_gene_id: A0A2U3VC57
symbol: RNF168
gene_biotype: protein_coding
description:
  E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...]


ensembl_gene_id: A0A2U3VC63
symbol: PLCG2
gene_biotype: protein_coding
description:
  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.


ensembl_gene_id: A0A2U3VC64
symbol: HSD17B2
gene_biotype: protein_coding
description:
  Estradiol 17-beta-dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family.


ensembl_gene_id: A0A2U3VC73
symbol: HSDL1
gene_biotype: protein_coding
description:
  Inactive hydroxysteroid dehydrogenase-like protein 1 isoform X1; Belongs to the short-chain dehydrogenases/reductases (SDR) family.


ensembl_gene_id: A0A2U3VC97
symbol: MVD
gene_biotype: protein_coding
description:
  Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes.


ensembl_gene_id: A0A2U3VCA3
symbol: LOC101364731
gene_biotype: protein_coding
description:
  Cytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.


ensembl_gene_id: A0A2U3VCC2
symbol: LOC101373190
gene_biotype: protein_coding
description:
  5-hydroxyisourate hydrolase; Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.


ensembl_gene_id: A0A2U3VCE8
symbol: DUSP1
gene_biotype: protein_coding
description:
  Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.


ensembl_gene_id: A0A2U3VCG1
symbol: KIF24
gene_biotype: protein_coding
description:
  Kinesin-like protein KIF24; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.


ensembl_gene_id: A0A2U3VCG6
symbol: KIAA1161
gene_biotype: protein_coding
description:
  Uncharacterized family 31 glucosidase KIAA1161 homolog; Belongs to the glycosyl hydrolase 31 family.


ensembl_gene_id: A0A2U3VCL6
symbol: GCSH
gene_biotype: protein_coding
description:
  Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.


ensembl_gene_id: A0A2U3VCL9
symbol: GBA2
gene_biotype: protein_coding
description:
  Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide.


ensembl_gene_id: A0A2U3VCN7
symbol: USP10
gene_biotype: protein_coding
description:
  Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family.


ensembl_gene_id: A0A2U3VCQ2
symbol: JPH3
gene_biotype: protein_coding
description:
  Junctophilin; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.


ensembl_gene_id: A0A2U3VCT8
symbol: SEC61B
gene_biotype: protein_coding
description:
  Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum.


ensembl_gene_id: A0A2U3VCW7
symbol: DUSP19
gene_biotype: protein_coding
description:
  Dual specificity protein phosphatase 19; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.


ensembl_gene_id: A0A2U3VCX5
symbol: NUP35
gene_biotype: protein_coding
description:
  Nucleoporin NUP53; Functions as a component of the nuclear pore complex (NPC). Belongs to the Nup35 family.


ensembl_gene_id: A0A2U3VCX7
symbol: CALCRL
gene_biotype: protein_coding
description:
  Calcitonin gene-related peptide type 1 receptor; Belongs to the G-protein coupled receptor 2 family.


ensembl_gene_id: A0A2U3VCY4
symbol: LOC101371236
gene_biotype: protein_coding
description:
  cAMP-regulated phosphoprotein 19-like; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. Belongs to the endosulfine family.


ensembl_gene_id: A0A2U3VCZ2
symbol: SLC40A1
gene_biotype: protein_coding
description:
  Solute carrier family 40 protein; May be involved in iron transport and iron homeostasis. Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.


ensembl_gene_id: A0A2U3VCZ3
symbol: OSGEPL1
gene_biotype: protein_coding
description:
  Probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.


ensembl_gene_id: A0A2U3VD00
symbol: HIBCH
gene_biotype: protein_coding
description:
  3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.


ensembl_gene_id: A0A2U3VD46
symbol: CLTA
gene_biotype: protein_coding
description:
  Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family.


ensembl_gene_id: A0A2U3VD61
symbol: CRAT
gene_biotype: protein_coding
description:
  Carnitine O-acetyltransferase isoform X1; Belongs to the carnitine/choline acetyltransferase family.


ensembl_gene_id: A0A2U3VD69
symbol: GRHPR
gene_biotype: protein_coding
description:
  Glyoxylate reductase/hydroxypyruvate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.


ensembl_gene_id: A0A2U3VD99
symbol: URM1
gene_biotype: protein_coding
description:
  Ubiquitin-related modifier 1; Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for co [...]


ensembl_gene_id: A0A2U3VDA2
symbol: DNM1
gene_biotype: protein_coding
description:
  Dynamin-1 isoform X1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.


ensembl_gene_id: A0A2U3VDB4
symbol: ST6GALNAC4
gene_biotype: protein_coding
description:
  N-acetylgalactosaminide alpha-2,6-sialyltransferase (sialyltransferase 7D); Belongs to the glycosyltransferase 29 family.


ensembl_gene_id: A0A2U3VDC2
symbol: ST6GALNAC6
gene_biotype: protein_coding
description:
  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; Belongs to the glycosyltransferase 29 family.


ensembl_gene_id: A0A2U3VDC7
symbol: FPGS
gene_biotype: protein_coding
description:
  Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family.


ensembl_gene_id: A0A2U3VDD4
symbol: DPM2
gene_biotype: protein_coding
description:
  Dolichol phosphate-mannose biosynthesis regulatory protein; Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization. Belongs to the DPM2 family.


ensembl_gene_id: A0A2U3VDD5
symbol: SLC2A8
gene_biotype: protein_coding
description:
  Solute carrier family 2, facilitated glucose transporter member 8 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.


ensembl_gene_id: A0A2U3VDD9
symbol: AK1
gene_biotype: protein_coding
description:
  Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.


ensembl_gene_id: A0A2U3VDF9
symbol: SCAI
gene_biotype: protein_coding
description:
  Protein SCAI; Tumor suppressor which functions to suppress MRTFA-induced SRF transcriptional activity.


ensembl_gene_id: A0A2U3VDG6
symbol: MYO1B
gene_biotype: protein_coding
description:
  Unconventional myosin-Ib; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.


ensembl_gene_id: A0A2U3VDL3
symbol: ATP2B2
gene_biotype: protein_coding
description:
  Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.


ensembl_gene_id: A0A2U3VDM1
symbol: PPP2R4
gene_biotype: protein_coding
description:
  Serine/threonine-protein phosphatase 2A activator; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.


ensembl_gene_id: A0A2U3VDR1
symbol: COQ4
gene_biotype: protein_coding
description:
  Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial; Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides; Belongs to the COQ4 family.


ensembl_gene_id: A0A2U3VDR3
symbol: CACNA1S
gene_biotype: protein_coding
description:
  Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.


ensembl_gene_id: A0A2U3VDR4
symbol: ARPC4
gene_biotype: protein_coding
description:
  Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family.


ensembl_gene_id: A0A2U3VDT1
symbol: KIF21B
gene_biotype: protein_coding
description:
  Kinesin-like protein KIF21B isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.


ensembl_gene_id: A0A2U3VDW4
symbol: TIMM17A
gene_biotype: protein_coding
description:
  Mitochondrial import inner membrane translocase subunit TIM17; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.


ensembl_gene_id: A0A2U3VDW6
symbol: ARL8A
gene_biotype: protein_coding
description:
  ADP-ribosylation factor-like protein 8A isoform X1; Belongs to the small GTPase superfamily. Arf family.


ensembl_gene_id: A0A2U3VDY2
symbol: LOC101371240
gene_biotype: protein_coding
description:
  Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.


ensembl_gene_id: A0A2U3VDY3
symbol: LOC101372911
gene_biotype: protein_coding
description:
  NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.


ensembl_gene_id: A0A2U3VE35
symbol: SLC26A9
gene_biotype: protein_coding
description:
  Solute carrier family 26 member 9; DIDS- and thiosulfate- sensitive anion exchanger mediating chloride, sulfate and oxalate transport. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.


ensembl_gene_id: A0A2U3VE40
symbol: AVPR1B
gene_biotype: protein_coding
description:
  Vasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.


ensembl_gene_id: A0A2U3VE52
symbol: CSN3
gene_biotype: protein_coding
description:
  Kappa-casein; Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk; Belongs to the kappa-casein family.


ensembl_gene_id: A0A2U3VEB7
symbol: NSUN6
gene_biotype: protein_coding
description:
  Putative methyltransferase NSUN6; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.


ensembl_gene_id: A0A2U3VED1
symbol: TRDMT1
gene_biotype: protein_coding
description:
  tRNA (Cytosine(38)-C(5))-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.


ensembl_gene_id: A0A2U3VEE5
symbol: ADORA1
gene_biotype: protein_coding
description:
  Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.


ensembl_gene_id: A0A2U3VEG9
symbol: PIK3C2B
gene_biotype: protein_coding
description:
  Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta; Belongs to the PI3/PI4-kinase family.


ensembl_gene_id: A0A2U3VEH3
symbol: KIF3B
gene_biotype: protein_coding
description:
  Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.


ensembl_gene_id: A0A2U3VEX0
symbol: RPN2
gene_biotype: protein_coding
description:
  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...]


ensembl_gene_id: A0A2U3VF02
symbol: SLC2A2
gene_biotype: protein_coding
description:
  Solute carrier family 2, facilitated glucose transporter member 2 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.


ensembl_gene_id: A0A2U3VF29
symbol: CLDN11
gene_biotype: protein_coding
description:
  Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.


ensembl_gene_id: A0A2U3VF43
symbol: ST3GAL2
gene_biotype: protein_coding
description:
  CMP-N-acetylneuraminate-beta-galactosamide- alpha-2,3-sialyltransferase 2; Belongs to the glycosyltransferase 29 family.


ensembl_gene_id: A0A2U3VF86
symbol: NIP7
gene_biotype: protein_coding
description:
  60S ribosome subunit biogenesis protein NIP7 homolog; Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly; Belongs to the NIP7 family.


ensembl_gene_id: A0A2U3VF88
symbol: HP
gene_biotype: protein_coding
description:
  Haptoglobin; As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway.


ensembl_gene_id: A0A2U3VFG2
symbol: ATP6V0D1
gene_biotype: protein_coding
description:
  V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family.


ensembl_gene_id: A0A2U3VFI8
symbol: PDF
gene_biotype: protein_coding
description:
  Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins; Belongs to the polypeptide deformylase family.


ensembl_gene_id: A0A2U3VFJ5
symbol: DYNC1LI2
gene_biotype: protein_coding
description:
  Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.


ensembl_gene_id: A0A2U3VFL2
symbol: AARS
gene_biotype: protein_coding
description:
  alanine--tRNA ligase, cytoplasmic; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family.


ensembl_gene_id: A0A2U3VFL4
symbol: WDR12
gene_biotype: protein_coding
description:
  Ribosome biogenesis protein WDR12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.


ensembl_gene_id: A0A2U3VFL6
symbol: BMPR2
gene_biotype: protein_coding
description:
  Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.


ensembl_gene_id: A0A2U3VFN2
symbol: NIF3L1
gene_biotype: protein_coding
description:
  NIF3-like protein 1; May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation.


ensembl_gene_id: A0A2U3VFP5
symbol: DHODH
gene_biotype: protein_coding
description:
  Dihydroorotate dehydrogenase (quinone), mitochondrial; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.


ensembl_gene_id: A0A2U3VFP9
symbol: PGAP1
gene_biotype: protein_coding
description:
  GPI inositol-deacylase; Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI- anchored proteins from the endoplasmic reticulum to the Golgi.


ensembl_gene_id: A0A2U3VFS8
symbol: GLDC
gene_biotype: protein_coding
description:
  Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine.


ensembl_gene_id: A0A2U3VFU5
symbol: SRP9
gene_biotype: protein_coding
description:
  Signal recognition particle 9 kDa protein; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.


ensembl_gene_id: A0A2U3VFV6
symbol: PARP1
gene_biotype: protein_coding
description:
  Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.


ensembl_gene_id: A0A2U3VFW8
symbol: SLC9A5
gene_biotype: protein_coding
description:
  Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.


ensembl_gene_id: A0A2U3VFX7
symbol: IPPK
gene_biotype: protein_coding
description:
  Inositol-pentakisphosphate 2-kinase; Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).


ensembl_gene_id: A0A2U3VG37
symbol: PPIL3
gene_biotype: protein_coding
description:
  Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.


ensembl_gene_id: A0A2U3VG52
symbol: LOC101372132
gene_biotype: protein_coding
description:
  Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.


ensembl_gene_id: A0A2U3VG92
symbol: FABP5
gene_biotype: protein_coding
description:
  Fatty acid-binding protein, epidermal; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.


ensembl_gene_id: A0A2U3VGA1
symbol: PSEN2
gene_biotype: protein_coding
description:
  Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.


ensembl_gene_id: A0A2U3VGA8
symbol: FABP4
gene_biotype: protein_coding
description:
  Fatty acid-binding protein, adipocyte; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.


ensembl_gene_id: A0A2U3VGB3
symbol: FABP12
gene_biotype: protein_coding
description:
  Fatty acid-binding protein 12; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.


ensembl_gene_id: A0A2U3VGD3
symbol: ST8SIA4
gene_biotype: protein_coding
description:
  CMP-N-acetylneuraminate-poly-alpha-2, 8-sialyltransferase; Belongs to the glycosyltransferase 29 family.


ensembl_gene_id: A0A2U3VGE1
symbol: FER
gene_biotype: protein_coding
description:
  Tyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.


ensembl_gene_id: A0A2U3VGE7
symbol: HGF
gene_biotype: protein_coding
description:
  Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.


ensembl_gene_id: A0A2U3VGF4
symbol: MRGPRF
gene_biotype: protein_coding
description:
  Mas-related G-protein coupled receptor member F; Belongs to the G-protein coupled receptor 1 family.


ensembl_gene_id: A0A2U3VGF8
symbol: NADSYN1
gene_biotype: protein_coding
description:
  Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family.


ensembl_gene_id: A0A2U3VGH9
symbol: TCIRG1
gene_biotype: protein_coding
description:
  V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.


ensembl_gene_id: A0A2U3VGJ4
symbol: NDUFV1
gene_biotype: protein_coding
description:
  NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain.


ensembl_gene_id: A0A2U3VGL5
symbol: PC
gene_biotype: protein_coding
description:
  Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.


ensembl_gene_id: A0A2U3VGL8
symbol: ADRBK1
gene_biotype: protein_coding
description:
  G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.


ensembl_gene_id: A0A2U3VGN2
symbol: MRPL11
gene_biotype: protein_coding
description:
  39S ribosomal protein L11, mitochondrial isoform X1; Belongs to the universal ribosomal protein uL11 family.


ensembl_gene_id: A0A2U3VGP9
symbol: FABP9
gene_biotype: protein_coding
description:
  Fatty acid-binding protein 9; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.


ensembl_gene_id: A0A2U3VGT5
symbol: LOC101386833
gene_biotype: protein_coding
description:
  Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.


ensembl_gene_id: A0A2U3VGV4
symbol: POLA2
gene_biotype: protein_coding
description:
  DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.


ensembl_gene_id: A0A2U3VGV6
symbol: CPT1A
gene_biotype: protein_coding
description:
  Carnitine O-palmitoyltransferase 1, liver isoform isoform X1; Belongs to the carnitine/choline acetyltransferase family.


ensembl_gene_id: A0A2U3VGV7
symbol: SLC25A45
gene_biotype: protein_coding
description:
  Solute carrier family 25 member 45 isoform X1; Belongs to the mitochondrial carrier (TC 2.A.29) family.


ensembl_gene_id: A0A2U3VGX2
symbol: MAP4K2
gene_biotype: protein_coding
description:
  Non-specific serine/threonine protein kinase; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.


ensembl_gene_id: A0A2U3VGX6
symbol: PPP2R5B
gene_biotype: protein_coding
description:
  Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.


ensembl_gene_id: A0A2U3VGY0
symbol: ARL2
gene_biotype: protein_coding
description:
  ADP-ribosylation factor-like protein 2 isoform X1; Belongs to the small GTPase superfamily. Arf family.


ensembl_gene_id: A0A2U3VGY6
symbol: PRDX5
gene_biotype: protein_coding
description:
  Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily.


ensembl_gene_id: A0A2U3VGZ1
symbol: CDC42BPG
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase MRCK gamma; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.


ensembl_gene_id: A0A2U3VH11
symbol: KCNK4
gene_biotype: protein_coding
description:
  Potassium channel subfamily K member 4 isoform X2; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.


ensembl_gene_id: A0A2U3VH19
symbol: PLCB3
gene_biotype: protein_coding
description:
  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.


ensembl_gene_id: A0A2U3VH25
symbol: PELI3
gene_biotype: protein_coding
description:
  E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.


ensembl_gene_id: A0A2U3VH33
symbol: FADD
gene_biotype: protein_coding
description:
  FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.


ensembl_gene_id: A0A2U3VH42
symbol: KCNK7
gene_biotype: protein_coding
description:
  Potassium channel subfamily K member 7; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.


ensembl_gene_id: A0A2U3VH66
symbol: GNGT1
gene_biotype: protein_coding
description:
  Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.


ensembl_gene_id: A0A2U3VH98
symbol: CDC42EP2
gene_biotype: protein_coding
description:
  Cdc42 effector protein 2; Probably involved in the organization of the actin cytoskeleton; Belongs to the BORG/CEP family.


ensembl_gene_id: A0A2U3VHA5
symbol: EIF3B
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 3 subunit B; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome; Belongs to the eIF-3 subunit B family.


ensembl_gene_id: A0A2U3VHB7
symbol: EHD1
gene_biotype: protein_coding
description:
  EH domain-containing protein 1 isoform X1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.


ensembl_gene_id: A0A2U3VHC2
symbol: PYGM
gene_biotype: protein_coding
description:
  Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.


ensembl_gene_id: A0A2U3VHG0
symbol: ARPC1A
gene_biotype: protein_coding
description:
  Actin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.


ensembl_gene_id: A0A2U3VHH9
symbol: LOC101366341
gene_biotype: protein_coding
description:
  Kinesin-like protein KIF19; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.


ensembl_gene_id: A0A2U3VHJ6
symbol: ETFDH
gene_biotype: protein_coding
description:
  Electron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone.


ensembl_gene_id: A0A2U3VHJ9
symbol: GLRB
gene_biotype: protein_coding
description:
  Glycine receptor subunit beta isoform X1; Belongs to the ligand-gated ion channel (TC 1.A.9) family.


ensembl_gene_id: A0A2U3VHK8
symbol: TDO2
gene_biotype: protein_coding
description:
  Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.


ensembl_gene_id: A0A2U3VHP4
symbol: ST6GALNAC2
gene_biotype: protein_coding
description:
  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 isoform X1; Belongs to the glycosyltransferase 29 family.


ensembl_gene_id: A0A2U3VHP8
symbol: ST6GALNAC1
gene_biotype: protein_coding
description:
  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 isoform X1; Belongs to the glycosyltransferase 29 family.


ensembl_gene_id: A0A2U3VHR5
symbol: SRP68
gene_biotype: protein_coding
description:
  Signal recognition particle subunit SRP68; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane; Belongs to the SRP68 family.


ensembl_gene_id: A0A2U3VHU5
symbol: SLC25A19
gene_biotype: protein_coding
description:
  Mitochondrial thiamine pyrophosphate carrier isoform X1; Belongs to the mitochondrial carrier (TC 2.A.29) family.


ensembl_gene_id: A0A2U3VHX6
symbol: SLC9A3R1
gene_biotype: protein_coding
description:
  Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression.


ensembl_gene_id: A0A2U3VHZ4
symbol: GUCY1A3
gene_biotype: protein_coding
description:
  Guanylate cyclase soluble subunit alpha-3; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.


ensembl_gene_id: A0A2U3VHZ8
symbol: USP16
gene_biotype: protein_coding
description:
  Ubiquitin carboxyl-terminal hydrolase 16; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.


ensembl_gene_id: A0A2U3VI01
symbol: PROSC
gene_biotype: protein_coding
description:
  Pyridoxal phosphate homeostasis protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'- phosphate (PLP), the active form of vitamin B6; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.


ensembl_gene_id: A0A2U3VI11
symbol: STAR
gene_biotype: protein_coding
description:
  Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.


ensembl_gene_id: A0A2U3VI32
symbol: GINS4
gene_biotype: protein_coding
description:
  DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family.


ensembl_gene_id: A0A2U3VI78
symbol: SLC24A4
gene_biotype: protein_coding
description:
  Sodium/potassium/calcium exchanger 4 isoform X1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.


ensembl_gene_id: A0A2U3VIC7
symbol: EIF3F
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 3 subunit F; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...]


ensembl_gene_id: A0A2U3VIE1
symbol: LSM1
gene_biotype: protein_coding
description:
  U6 snRNA-associated Sm-like protein LSm1; Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation.


ensembl_gene_id: A0A2U3VIE4
symbol: AMPD3
gene_biotype: protein_coding
description:
  AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.


ensembl_gene_id: A0A2U3VIH5
symbol: KCNK13
gene_biotype: protein_coding
description:
  Potassium channel subfamily K member 13; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.


ensembl_gene_id: A0A2U3VIJ4
symbol: PTH
gene_biotype: protein_coding
description:
  Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family.


ensembl_gene_id: A0A2U3VIR1
symbol: PIGV
gene_biotype: protein_coding
description:
  GPI mannosyltransferase 2; Mannosyltransferase involved in glycosylphosphatidylinositol- anchor biosynthesis.


ensembl_gene_id: A0A2U3VIR2
symbol: GPN2
gene_biotype: protein_coding
description:
  GPN-loop GTPase 2; Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family.


ensembl_gene_id: A0A2U3VIU4
symbol: RHCE
gene_biotype: protein_coding
description:
  Blood group Rh(CE) polypeptide isoform X1; Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.


ensembl_gene_id: A0A2U3VIV3
symbol: RUNX3
gene_biotype: protein_coding
description:
  Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.


ensembl_gene_id: A0A2U3VIW9
symbol: FUCA1
gene_biotype: protein_coding
description:
  Alpha-L-fucosidase; Alpha-L-fucosidase is responsible for hydrolyzing the alpha- 1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.


ensembl_gene_id: A0A2U3VJ13
symbol: GPD2
gene_biotype: protein_coding
description:
  Glycerol-3-phosphate dehydrogenase; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.


ensembl_gene_id: A0A2U3VJ51
symbol: GPN1
gene_biotype: protein_coding
description:
  GPN-loop GTPase; Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.


ensembl_gene_id: A0A2U3VJ76
symbol: SLC5A6
gene_biotype: protein_coding
description:
  Sodium-dependent multivitamin transporter; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.


ensembl_gene_id: A0A2U3VJA3
symbol: EPT1
gene_biotype: protein_coding
description:
  Ethanolaminephosphotransferase 1; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.


ensembl_gene_id: A0A2U3VJB3
symbol: DNMT3A
gene_biotype: protein_coding
description:
  DNA (Cytosine-5)-methyltransferase 3A isoform X1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.


ensembl_gene_id: A0A2U3VJB6
symbol: KDM1A
gene_biotype: protein_coding
description:
  Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.


ensembl_gene_id: A0A2U3VJB8
symbol: ADCY3
gene_biotype: protein_coding
description:
  Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.


ensembl_gene_id: A0A2U3VJE3
symbol: ADGRF3
gene_biotype: protein_coding
description:
  LOW QUALITY PROTEIN: probable G-protein coupled receptor 113; Belongs to the G-protein coupled receptor 2 family.


ensembl_gene_id: A0A2U3VJF7
symbol: POLR2B
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.


ensembl_gene_id: A0A2U3VJG1
symbol: LOC101364459
gene_biotype: protein_coding
description:
  Ribonuclease P protein subunit p20; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences; Belongs to the histone-like Alba family.


ensembl_gene_id: A0A2U3VJG6
symbol: MTG1
gene_biotype: protein_coding
description:
  Mitochondrial GTPase 1; Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity. Displays mitochondrial GTPase activity; Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.


ensembl_gene_id: A0A2U3VJH6
symbol: TUBGCP2
gene_biotype: protein_coding
description:
  Gamma-tubulin complex component; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome; Belongs to the TUBGCP family.


ensembl_gene_id: A0A2U3VJK4
symbol: GJD3
gene_biotype: protein_coding
description:
  Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.


ensembl_gene_id: A0A2U3VJK9
symbol: CDC6
gene_biotype: protein_coding
description:
  Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family.


ensembl_gene_id: A0A2U3VJN3
symbol: PGAP3
gene_biotype: protein_coding
description:
  Post-GPI attachment to proteins factor 3; Involved in the lipid remodeling steps of GPI-anchor maturation; Belongs to the PGAP3 family.


ensembl_gene_id: A0A2U3VJP3
symbol: MED1
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.


ensembl_gene_id: A0A2U3VJP9
symbol: ARL5C
gene_biotype: protein_coding
description:
  Putative ADP-ribosylation factor-like protein 5C; Belongs to the small GTPase superfamily. Arf family.


ensembl_gene_id: A0A2U3VJT2
symbol: COPZ2
gene_biotype: protein_coding
description:
  Coatomer subunit zeta; The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.


ensembl_gene_id: A0A2U3VJU5
symbol: HOXB9
gene_biotype: protein_coding
description:
  Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family.


ensembl_gene_id: A0A2U3VJV1
symbol: ATP5G1
gene_biotype: protein_coding
description:
  ATP synthase F(0) complex subunit C1, mitochondrial isoform X1; Belongs to the ATPase C chain family.


ensembl_gene_id: A0A2U3VJV5
symbol: SNF8
gene_biotype: protein_coding
description:
  Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family.


ensembl_gene_id: A0A2U3VJW6
symbol: TOP2A
gene_biotype: protein_coding
description:
  DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks.


ensembl_gene_id: A0A2U3VJZ8
symbol: CACNA1G
gene_biotype: protein_coding
description:
  Voltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the low-voltage activated (LVA) group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...]


ensembl_gene_id: A0A2U3VK62
symbol: HPGD
gene_biotype: protein_coding
description:
  15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform X1; Belongs to the short-chain dehydrogenases/reductases (SDR) family.


ensembl_gene_id: A0A2U3VK67
symbol: GLRA3
gene_biotype: protein_coding
description:
  Glycine receptor subunit alpha-3 isoform X1; Belongs to the ligand-gated ion channel (TC 1.A.9) family.


ensembl_gene_id: A0A2U3VK80
symbol: LOC101378226
gene_biotype: protein_coding
description:
  Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family.


ensembl_gene_id: A0A2U3VK89
symbol: GTF2F1
gene_biotype: protein_coding
description:
  Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family.


ensembl_gene_id: A0A2U3VKA2
symbol: SLC25A23
gene_biotype: protein_coding
description:
  Calcium-binding mitochondrial carrier protein SCaMC-3; Belongs to the mitochondrial carrier (TC 2.A.29) family.


ensembl_gene_id: A0A2U3VKB2
symbol: RSAD1
gene_biotype: protein_coding
description:
  Radical S-adenosyl methionine domain-containing protein; May be a heme chaperone, appears to bind heme. Homologous bacterial proteins do not have oxygen-independent coproporphyrinogen- III oxidase activity. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L- methionine; Belongs to the anaerobic coproporphyrinogen-III oxidase family.


ensembl_gene_id: A0A2U3VKB5
symbol: LOC101368303
gene_biotype: protein_coding
description:
  MICOS complex subunit MIC13; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.


ensembl_gene_id: A0A2U3VKE8
symbol: MAP2K2
gene_biotype: protein_coding
description:
  Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily.


ensembl_gene_id: A0A2U3VKF4
symbol: DOHH
gene_biotype: protein_coding
description:
  Deoxyhypusine hydroxylase; Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L- lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor; Belongs to the deoxyhypusine hydroxylase family.


ensembl_gene_id: A0A2U3VKG1
symbol: NFIC
gene_biotype: protein_coding
description:
  Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.


ensembl_gene_id: A0A2U3VKI1
symbol: NCLN
gene_biotype: protein_coding
description:
  Nicalin; May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning.


ensembl_gene_id: A0A2U3VKK2
symbol: MKNK2
gene_biotype: protein_coding
description:
  MAP kinase-interacting serine/threonine-protein kinase 2 isoform X1; Belongs to the protein kinase superfamily.


ensembl_gene_id: A0A2U3VKL7
symbol: NDUFS7
gene_biotype: protein_coding
description:
  NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1; Belongs to the complex I 20 kDa subunit family.


ensembl_gene_id: A0A2U3VKM2
symbol: GAMT
gene_biotype: protein_coding
description:
  Guanidinoacetate N-methyltransferase; Converts guanidinoacetate to creatine, using S- adenosylmethionine as the methyl donor. Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family.


ensembl_gene_id: A0A2U3VKP6
symbol: POLRMT
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the phage and mitochondrial RNA polymerase family.


ensembl_gene_id: A0A2U3VKR3
symbol: SLC25A41
gene_biotype: protein_coding
description:
  LOW QUALITY PROTEIN: solute carrier family 25 member 41; Belongs to the mitochondrial carrier (TC 2.A.29) family.


ensembl_gene_id: A0A2U3VKS4
symbol: GRIN3B
gene_biotype: protein_coding
description:
  Glutamate receptor ionotropic, NMDA 3B; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.


ensembl_gene_id: A0A2U3VKX1
symbol: EVL
gene_biotype: protein_coding
description:
  ena/VASP-like protein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family.


ensembl_gene_id: A0A2U3VL03
symbol: CNN2
gene_biotype: protein_coding
description:
  Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.


ensembl_gene_id: A0A2U3VL07
symbol: TRMT61A
gene_biotype: protein_coding
description:
  tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A; Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.


ensembl_gene_id: A0A2U3VL08
symbol: MED16
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 16; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.


ensembl_gene_id: A0A2U3VL20
symbol: ADSSL1
gene_biotype: protein_coding
description:
  Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.


ensembl_gene_id: A0A2U3VL24
symbol: SIVA1
gene_biotype: protein_coding
description:
  Apoptosis regulatory protein Siva; Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl- x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.


ensembl_gene_id: A0A2U3VL51
symbol: HCN2
gene_biotype: protein_coding
description:
  LOW QUALITY PROTEIN: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2.


ensembl_gene_id: A0A2U3VL52
symbol: TSEN2
gene_biotype: protein_coding
description:
  tRNA-splicing endonuclease subunit Sen2; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural [...]


ensembl_gene_id: A0A2U3VL62
symbol: MBD4
gene_biotype: protein_coding
description:
  Methyl-CpG-binding domain protein 4; Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein.


ensembl_gene_id: A0A2U3VL80
symbol: LSM3
gene_biotype: protein_coding
description:
  U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA.


ensembl_gene_id: A0A2U3VL92
symbol: SLC25A29
gene_biotype: protein_coding
description:
  Mitochondrial basic amino acids transporter isoform X1; Belongs to the mitochondrial carrier (TC 2.A.29) family.


ensembl_gene_id: A0A2U3VLA5
symbol: RPN1
gene_biotype: protein_coding
description:
  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...]


ensembl_gene_id: A0A2U3VLB1
symbol: RUVBL1
gene_biotype: protein_coding
description:
  RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.


ensembl_gene_id: A0A2U3VLC1
symbol: CDC42BPB
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase MRCK beta; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.


ensembl_gene_id: A0A2U3VLE1
symbol: KIF26A
gene_biotype: protein_coding
description:
  Kinesin-like protein KIF26A; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.


ensembl_gene_id: A0A2U3VLE9
symbol: SETD6
gene_biotype: protein_coding
description:
  N-lysine methyltransferase SETD6; Protein-lysine N-methyltransferase. Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily.


ensembl_gene_id: A0A2U3VLG3
symbol: USB1
gene_biotype: protein_coding
description:
  U6 snRNA phosphodiesterase; Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate; Belongs to the 2H phosphoesterase superfamily. USB1 family.


ensembl_gene_id: A0A2U3VLG9
symbol: KATNB1
gene_biotype: protein_coding
description:
  Katanin p80 WD40 repeat-containing subunit B1; Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Micr [...]


ensembl_gene_id: A0A2U3VLH3
symbol: PPARG
gene_biotype: protein_coding
description:
  Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]


ensembl_gene_id: A0A2U3VLJ6
symbol: CIAPIN1
gene_biotype: protein_coding
description:
  Anamorsin; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electron [...]


ensembl_gene_id: A0A2U3VLJ9
symbol: TRH
gene_biotype: protein_coding
description:
  Pro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems.


ensembl_gene_id: A0A2U3VLN0
symbol: VPS29
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.


ensembl_gene_id: A0A2U3VLP2
symbol: ARPC3
gene_biotype: protein_coding
description:
  Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.


ensembl_gene_id: A0A2U3VLP9
symbol: ALDH1L1
gene_biotype: protein_coding
description:
  10-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.


ensembl_gene_id: A0A2U3VLQ4
symbol: CHCHD6
gene_biotype: protein_coding
description:
  MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.


ensembl_gene_id: A0A2U3VLR2
symbol: GPN3
gene_biotype: protein_coding
description:
  GPN-loop GTPase 3; Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family.


ensembl_gene_id: A0A2U3VLW9
symbol: EIF2B1
gene_biotype: protein_coding
description:
  Translation initiation factor eIF-2B subunit alpha isoform X2; Belongs to the eIF-2B alpha/beta/delta subunits family.


ensembl_gene_id: A0A2U3VLX0
symbol: PFKM
gene_biotype: protein_coding
description:
  ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.


ensembl_gene_id: A0A2U3VLX3
symbol: LOC101374278
gene_biotype: protein_coding
description:
  Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals.


ensembl_gene_id: A0A2U3VM18
symbol: P2RX7
gene_biotype: protein_coding
description:
  P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family.


ensembl_gene_id: A0A2U3VM49
symbol: PSMD1
gene_biotype: protein_coding
description:
  26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family.


ensembl_gene_id: A0A2U3VM51
symbol: PDE6D
gene_biotype: protein_coding
description:
  Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta; Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide [...]


ensembl_gene_id: A0A2U3VM61
symbol: DIS3L2
gene_biotype: protein_coding
description:
  DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mi [...]


ensembl_gene_id: A0A2U3VMA0
symbol: HDAC7
gene_biotype: protein_coding
description:
  Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.


ensembl_gene_id: A0A2U3VMA2
symbol: VPS41
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways; Belongs to the VPS41 family.


ensembl_gene_id: A0A2U3VMC5
symbol: GUF1
gene_biotype: protein_coding
description:
  Translation factor GUF1, mitochondrial; Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.


ensembl_gene_id: A0A2U3VME0
symbol: NSUN7
gene_biotype: protein_coding
description:
  Putative methyltransferase NSUN7; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.


ensembl_gene_id: A0A2U3VMF1
symbol: UBE2K
gene_biotype: protein_coding
description:
  LOW QUALITY PROTEIN: ubiquitin-conjugating enzyme E2 K; Belongs to the ubiquitin-conjugating enzyme family.


ensembl_gene_id: A0A2U3VMF5
symbol: UGDH
gene_biotype: protein_coding
description:
  UDP-glucose 6-dehydrogenase; Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate. Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.


ensembl_gene_id: A0A2U3VMF6
symbol: LIAS
gene_biotype: protein_coding
description:
  Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.


ensembl_gene_id: A0A2U3VMG4
symbol: GRPEL1
gene_biotype: protein_coding
description:
  GrpE protein homolog; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the GrpE family.


ensembl_gene_id: A0A2U3VMH8
symbol: EIF4E2
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 4E type 2 isoform X1; Belongs to the eukaryotic initiation factor 4E family.


ensembl_gene_id: A0A2U3VMM2
symbol: SLC26A1
gene_biotype: protein_coding
description:
  Sulfate anion transporter 1; Mediates sulfate transport with high affinity. Mediates oxalate transport. Mediates bicarbonate transport. Does not accept succinate as cosubstrate; Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.


ensembl_gene_id: A0A2U3VMN3
symbol: KDR
gene_biotype: protein_coding
description:
  Vascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.


ensembl_gene_id: A0A2U3VMN4
symbol: ATP8A1
gene_biotype: protein_coding
description:
  Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.


ensembl_gene_id: A0A2U3VMR0
symbol: LOC101382106
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.


ensembl_gene_id: A0A2U3VMS3
symbol: GABRA2
gene_biotype: protein_coding
description:
  Gamma-aminobutyric acid receptor subunit alpha-2; Belongs to the ligand-gated ion channel (TC 1.A.9) family.


ensembl_gene_id: A0A2U3VMS8
symbol: BCKDHA
gene_biotype: protein_coding
description:
  2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).


ensembl_gene_id: A0A2U3VMT0
symbol: GABRA4
gene_biotype: protein_coding
description:
  Gamma-aminobutyric acid receptor subunit alpha-4 isoform X1; Belongs to the ligand-gated ion channel (TC 1.A.9) family.


ensembl_gene_id: A0A2U3VMT7
symbol: GABRB1
gene_biotype: protein_coding
description:
  Gamma-aminobutyric acid receptor subunit beta-1 isoform X2; Belongs to the ligand-gated ion channel (TC 1.A.9) family.


ensembl_gene_id: A0A2U3VMZ9
symbol: TIMM50
gene_biotype: protein_coding
description:
  Mitochondrial import inner membrane translocase subunit TIM50; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.


ensembl_gene_id: A0A2U3VN34
symbol: EIF3K
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 3 subunit K; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...]


ensembl_gene_id: A0A2U3VN67
symbol: POLR2I
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.


ensembl_gene_id: A0A2U3VNC2
symbol: SLC24A5
gene_biotype: protein_coding
description:
  Sodium/potassium/calcium exchanger 5 isoform X1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.


ensembl_gene_id: A0A2U3VND2
symbol: ECH1
gene_biotype: protein_coding
description:
  delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial; Belongs to the enoyl-CoA hydratase/isomerase family.


ensembl_gene_id: A0A2U3VNE6
symbol: ARPP19
gene_biotype: protein_coding
description:
  cAMP-regulated phosphoprotein 19; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. Belongs to the endosulfine family.


ensembl_gene_id: A0A2U3VNG3
symbol: MYO5A
gene_biotype: protein_coding
description:
  Unconventional myosin-Va isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.


ensembl_gene_id: A0A2U3VNH1
symbol: MYO5C
gene_biotype: protein_coding
description:
  Unconventional myosin-Vc; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.


ensembl_gene_id: A0A2U3VNK0
symbol: KIF4A
gene_biotype: protein_coding
description:
  Chromosome-associated kinesin KIF4A; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.


ensembl_gene_id: A0A2U3VNM7
symbol: GATC
gene_biotype: protein_coding
description:
  Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Belongs to the GatC family.


ensembl_gene_id: A0A2U3VNN2
symbol: SIRT4
gene_biotype: protein_coding
description:
  NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...]


ensembl_gene_id: A0A2U3VNN9
symbol: POP5
gene_biotype: protein_coding
description:
  Ribonuclease P/MRP protein subunit POP5; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.


ensembl_gene_id: A0A2U3VNS8
symbol: MED13L
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 13; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.


ensembl_gene_id: A0A2U3VNY6
symbol: LOC101375048
gene_biotype: protein_coding
description:
  LOW QUALITY PROTEIN: sperm acrosome-associated protein 5; Belongs to the glycosyl hydrolase 22 family.


ensembl_gene_id: A0A2U3VNY7
symbol: COQ5
gene_biotype: protein_coding
description:
  2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl- 6-methoxy-1,4-benzoquinol (DMQH2).


ensembl_gene_id: A0A2U3VNZ1
symbol: FTSJ1
gene_biotype: protein_coding
description:
  Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.


ensembl_gene_id: A0A2U3VNZ7
symbol: RPLP0
gene_biotype: protein_coding
description:
  60S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10.


ensembl_gene_id: A0A2U3VP01
symbol: LOC101375913
gene_biotype: protein_coding
description:
  Thymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family.


ensembl_gene_id: A0A2U3VP02
symbol: CIT
gene_biotype: protein_coding
description:
  Citron Rho-interacting kinase; Plays a role in cytokinesis. Displays serine/threonine protein kinase activity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.


ensembl_gene_id: A0A2U3VP04
symbol: SUV39H1
gene_biotype: protein_coding
description:
  Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.


ensembl_gene_id: A0A2U3VP33
symbol: LOC101382780
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 7; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery.


ensembl_gene_id: A0A2U3VP37
symbol: KCNK2
gene_biotype: protein_coding
description:
  Potassium channel subfamily K member 2 isoform X1; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.


ensembl_gene_id: A0A2U3VP92
symbol: PORCN
gene_biotype: protein_coding
description:
  Protein-serine O-palmitoleoyltransferase porcupine isoform X5; Belongs to the membrane-bound acyltransferase family.


ensembl_gene_id: A0A2U3VPA9
symbol: PIM2
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.


ensembl_gene_id: A0A2U3VPB0
symbol: SCN2A
gene_biotype: protein_coding
description:
  Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.


ensembl_gene_id: A0A2U3VPB6
symbol: DHRS9
gene_biotype: protein_coding
description:
  Dehydrogenase/reductase SDR family member 9; Belongs to the short-chain dehydrogenases/reductases (SDR) family.


ensembl_gene_id: A0A2U3VPF0
symbol: ATP6V1G1
gene_biotype: protein_coding
description:
  V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.


ensembl_gene_id: A0A2U3VPF9
symbol: ORM1
gene_biotype: protein_coding
description:
  Alpha-1-acid glycoprotein; Functions as transport protein in the blood stream. Belongs to the calycin superfamily. Lipocalin family.


ensembl_gene_id: A0A2U3VPH7
symbol: IKBKAP
gene_biotype: protein_coding
description:
  Elongator complex protein 1; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. Belongs to the ELP1/IKA1 family.


ensembl_gene_id: A0A2U3VPI6
symbol: LOC101375442
gene_biotype: protein_coding
description:
  Small nuclear ribonucleoprotein Sm D1; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA.


ensembl_gene_id: A0A2U3VPK3
symbol: BBS5
gene_biotype: protein_coding
description:
  Bardet-Biedl syndrome 5 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the gua [...]


ensembl_gene_id: A0A2U3VPN9
symbol: UBR3
gene_biotype: protein_coding
description:
  E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.


ensembl_gene_id: A0A2U3VPV2
symbol: TUFM
gene_biotype: protein_coding
description:
  Elongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis.


ensembl_gene_id: A0A2U3VPV9
symbol: SBK1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase SBK1; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.


ensembl_gene_id: A0A2U3VPW7
symbol: SLX1A
gene_biotype: protein_coding
description:
  Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products.


ensembl_gene_id: A0A2U3VPX9
symbol: LOC101379010
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 3 subunit C; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...]


ensembl_gene_id: A0A2U3VPZ0
symbol: MAPK3
gene_biotype: protein_coding
description:
  Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.


ensembl_gene_id: A0A2U3VQ02
symbol: SDHB
gene_biotype: protein_coding
description:
  Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).


ensembl_gene_id: A0A2U3VQ25
symbol: DCTPP1
gene_biotype: protein_coding
description:
  dCTP pyrophosphatase 1; Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.


ensembl_gene_id: A0A2U3VQ33
symbol: QPRT
gene_biotype: protein_coding
description:
  Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family.


ensembl_gene_id: A0A2U3VQ34
symbol: PHKG2
gene_biotype: protein_coding
description:
  Phosphorylase b kinase gamma catalytic chain, liver/testis isoform; Belongs to the protein kinase superfamily.


ensembl_gene_id: A0A2U3VQ37
symbol: SEPT1
gene_biotype: protein_coding
description:
  Septin-1; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.


ensembl_gene_id: A0A2U3VQ65
symbol: PRSS36
gene_biotype: protein_coding
description:
  Polyserase-2; Serine protease. Has a preference for substrates with an Arg instead of a Lys residue in position P1. Belongs to the peptidase S1 family.


ensembl_gene_id: A0A2U3VQ98
symbol: TRPC1
gene_biotype: protein_coding
description:
  Short transient receptor potential channel 1 isoform X1; Belongs to the transient receptor (TC 1.A.4) family.


ensembl_gene_id: A0A2U3VQE2
symbol: LOC101386944
gene_biotype: protein_coding
description:
  Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.


ensembl_gene_id: A0A2U3VQH1
symbol: SLC25A36
gene_biotype: protein_coding
description:
  Solute carrier family 25 member 36 isoform X1; Belongs to the mitochondrial carrier (TC 2.A.29) family.


ensembl_gene_id: A0A2U3VQH3
symbol: NDUFA6
gene_biotype: protein_coding
description:
  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 isoform X1; Belongs to the complex I LYR family.


ensembl_gene_id: A0A2U3VQI1
symbol: ATP1B3
gene_biotype: protein_coding
description:
  Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family.


ensembl_gene_id: A0A2U3VQJ8
symbol: NHP2L1
gene_biotype: protein_coding
description:
  Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family.


ensembl_gene_id: A0A2U3VQS0
symbol: ACTR2
gene_biotype: protein_coding
description:
  Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.


ensembl_gene_id: A0A2U3VQW4
symbol: SLC25A17
gene_biotype: protein_coding
description:
  Peroxisomal membrane protein PMP34 isoform X1; Belongs to the mitochondrial carrier (TC 2.A.29) family.


ensembl_gene_id: A0A2U3VR00
symbol: RDH11
gene_biotype: protein_coding
description:
  Retinol dehydrogenase 11 isoform X1; Belongs to the short-chain dehydrogenases/reductases (SDR) family.


ensembl_gene_id: A0A2U3VR29
symbol: SLC8A3
gene_biotype: protein_coding
description:
  Sodium/calcium exchanger 3 isoform X1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.


ensembl_gene_id: A0A2U3VR50
symbol: SEPT4
gene_biotype: protein_coding
description:
  Septin-4 isoform X1; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.


ensembl_gene_id: A0A2U3VR86
symbol: PIGW
gene_biotype: protein_coding
description:
  Phosphatidylinositol-glycan biosynthesis class W protein; Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.


ensembl_gene_id: A0A2U3VR94
symbol: DHRS11
gene_biotype: protein_coding
description:
  Dehydrogenase/reductase SDR family member 11; Belongs to the short-chain dehydrogenases/reductases (SDR) family.


ensembl_gene_id: A0A2U3VRC6
symbol: SLC2A5
gene_biotype: protein_coding
description:
  Solute carrier family 2, facilitated glucose transporter member 5; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.


ensembl_gene_id: A0A2U3VRG5
symbol: CD14
gene_biotype: protein_coding
description:
  Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...]


ensembl_gene_id: A0A2U3VRG9
symbol: NDUFA2
gene_biotype: protein_coding
description:
  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.


ensembl_gene_id: A0A2U3VRH2
symbol: RPS6KB1
gene_biotype: protein_coding
description:
  Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.


ensembl_gene_id: A0A2U3VRH8
symbol: WDR55
gene_biotype: protein_coding
description:
  WD repeat-containing protein 55; Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis. Belongs to the WD repeat WDR55 family.


ensembl_gene_id: A0A2U3VRK3
symbol: MYO19
gene_biotype: protein_coding
description:
  Unconventional myosin-XIX; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.


ensembl_gene_id: A0A2U3VRM8
symbol: FGF1
gene_biotype: protein_coding
description:
  Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]


ensembl_gene_id: A0A2U3VRN0
symbol: EGR1
gene_biotype: protein_coding
description:
  Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family.


ensembl_gene_id: A0A2U3VRT4
symbol: QRSL1
gene_biotype: protein_coding
description:
  Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Belongs to the amidase family. GatA subfamily.


ensembl_gene_id: A0A2U3VRW2
symbol: PLN
gene_biotype: protein_coding
description:
  Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.


ensembl_gene_id: A0A2U3VRY2
symbol: TRAPPC3L
gene_biotype: protein_coding
description:
  Trafficking protein particle complex subunit; May play a role in vesicular transport from endoplasmic reticulum to Golgi.


ensembl_gene_id: A0A2U3VS06
symbol: COPG2
gene_biotype: protein_coding
description:
  Coatomer subunit gamma; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.


ensembl_gene_id: A0A2U3VS31
symbol: SND1
gene_biotype: protein_coding
description:
  Staphylococcal nuclease domain-containing protein; Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs.


ensembl_gene_id: A0A2U3VS41
symbol: ATP6V1F
gene_biotype: protein_coding
description:
  V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.


ensembl_gene_id: A0A2U3VS59
symbol: LEP
gene_biotype: protein_coding
description:
  Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]


ensembl_gene_id: A0A2U3VSA9
symbol: KCNK10
gene_biotype: protein_coding
description:
  Potassium channel subfamily K member 10; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.


ensembl_gene_id: A0A2U3VSB9
symbol: PTPN21
gene_biotype: protein_coding
description:
  Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily.


ensembl_gene_id: A0A2U3VSF6
symbol: VPS16
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS16 family.


ensembl_gene_id: A0A2U3VSH0
symbol: KDSR
gene_biotype: protein_coding
description:
  3-ketodihydrosphingosine reductase isoform X1; Belongs to the short-chain dehydrogenases/reductases (SDR) family.


ensembl_gene_id: A0A2U3VSH9
symbol: ITPA
gene_biotype: protein_coding
description:
  Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family.


ensembl_gene_id: A0A2U3VSK6
symbol: PCNA
gene_biotype: protein_coding
description:
  Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.


ensembl_gene_id: A0A2U3VSM9
symbol: SEC16B
gene_biotype: protein_coding
description:
  Protein transport protein sec16; Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus.


ensembl_gene_id: A0A2U3VSQ2
symbol: IDH2
gene_biotype: protein_coding
description:
  Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family.


ensembl_gene_id: A0A2U3VSR7
symbol: VPS33B
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 33B isoform X1; Belongs to the STXBP/unc-18/SEC1 family.


ensembl_gene_id: A0A2U3VST2
symbol: RHCG
gene_biotype: protein_coding
description:
  Ammonium transporter Rh type C; Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.


ensembl_gene_id: A0A2U3VSU1
symbol: TRMT6
gene_biotype: protein_coding
description:
  tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6; Substrate-binding subunit of tRNA (adenine-N1-)- methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.


ensembl_gene_id: A0A2U3VSU8
symbol: SLC28A1
gene_biotype: protein_coding
description:
  Sodium/nucleoside cotransporter; Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.


ensembl_gene_id: A0A2U3VSV1
symbol: PRKCQ
gene_biotype: protein_coding
description:
  Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.


ensembl_gene_id: A0A2U3VSY5
symbol: POLR3GL
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerase III subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.


ensembl_gene_id: A0A2U3VSZ5
symbol: POLR3C
gene_biotype: protein_coding
description:
  RNA polymerase III subunit C3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.


ensembl_gene_id: A0A2U3VT08
symbol: SEPT10
gene_biotype: protein_coding
description:
  Septin-10; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.


ensembl_gene_id: A0A2U3VT21
symbol: MRPS11
gene_biotype: protein_coding
description:
  28S ribosomal protein S11, mitochondrial isoform X1; Belongs to the universal ribosomal protein uS11 family.


ensembl_gene_id: A0A2U3VT39
symbol: DHRS7C
gene_biotype: protein_coding
description:
  Dehydrogenase/reductase SDR family member 7C isoform X1; Belongs to the short-chain dehydrogenases/reductases (SDR) family.


ensembl_gene_id: A0A2U3VT42
symbol: RBM8A
gene_biotype: protein_coding
description:
  RNA-binding protein 8A; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.


ensembl_gene_id: A0A2U3VT79
symbol: LOC101367049
gene_biotype: protein_coding
description:
  Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.


ensembl_gene_id: A0A2U3VT92
symbol: LOC101383940
gene_biotype: protein_coding
description:
  60S acidic ribosomal protein P1-like isoform X1; Belongs to the eukaryotic ribosomal protein P1/P2 family.


ensembl_gene_id: A0A2U3VT93
symbol: LOC101373629
gene_biotype: protein_coding
description:
  Small nuclear ribonucleoprotein Sm D2; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome.


ensembl_gene_id: A0A2U3VT95
symbol: TP53
gene_biotype: protein_coding
description:
  Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.


ensembl_gene_id: A0A2U3VTA7
symbol: ENTPD6
gene_biotype: protein_coding
description:
  LOW QUALITY PROTEIN: ectonucleoside triphosphate diphosphohydrolase 6; Belongs to the GDA1/CD39 NTPase family.


ensembl_gene_id: A0A2U3VTA8
symbol: POLR2A
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.


ensembl_gene_id: A0A2U3VTC4
symbol: TNK1
gene_biotype: protein_coding
description:
  Non-receptor tyrosine-protein kinase TNK1 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family.


ensembl_gene_id: A0A2U3VTD2
symbol: SLC2A4
gene_biotype: protein_coding
description:
  Solute carrier family 2, facilitated glucose transporter member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.


ensembl_gene_id: A0A2U3VTF5
symbol: LOC101365786
gene_biotype: protein_coding
description:
  Tumor necrosis factor ligand superfamily member 13 isoform X1; Belongs to the tumor necrosis factor family.


ensembl_gene_id: A0A2U3VTG9
symbol: PLSCR3
gene_biotype: protein_coding
description:
  Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family.


ensembl_gene_id: A0A2U3VTI1
symbol: SLC25A11
gene_biotype: protein_coding
description:
  Mitochondrial 2-oxoglutarate/malate carrier protein isoform X1; Belongs to the mitochondrial carrier (TC 2.A.29) family.


ensembl_gene_id: A0A2U3VTI8
symbol: DERL2
gene_biotype: protein_coding
description:
  Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.


ensembl_gene_id: A0A2U3VTL3
symbol: MED11
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 11; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.


ensembl_gene_id: A0A2U3VTN4
symbol: ATP6V1B1
gene_biotype: protein_coding
description:
  Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family.


ensembl_gene_id: A0A2U3VTP9
symbol: MED31
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 31; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.


ensembl_gene_id: A0A2U3VTR8
symbol: CCT7
gene_biotype: protein_coding
description:
  T-complex protein 1 subunit eta; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.


ensembl_gene_id: A0A2U3VTS9
symbol: SNRPG
gene_biotype: protein_coding
description:
  Small nuclear ribonucleoprotein G; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing.


ensembl_gene_id: A0A2U3VTW2
symbol: EXOC6B
gene_biotype: protein_coding
description:
  Exocyst complex component; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.


ensembl_gene_id: A0A2U3VU13
symbol: SLC5A11
gene_biotype: protein_coding
description:
  Sodium/myo-inositol cotransporter 2 isoform X1; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.


ensembl_gene_id: A0A2U3VU27
symbol: SCNN1G
gene_biotype: protein_coding
description:
  Amiloride-sensitive sodium channel subunit gamma; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.


ensembl_gene_id: A0A2U3VU28
symbol: EARS2
gene_biotype: protein_coding
description:
  Probable glutamate--tRNA ligase, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family.


ensembl_gene_id: A0A2U3VU30
symbol: SCNN1B
gene_biotype: protein_coding
description:
  Amiloride-sensitive sodium channel subunit beta; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.


ensembl_gene_id: A0A2U3VU73
symbol: DNMT1
gene_biotype: protein_coding
description:
  DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.


ensembl_gene_id: A0A2U3VU88
symbol: ATG4D
gene_biotype: protein_coding
description:
  Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family.


ensembl_gene_id: A0A2U3VUB6
symbol: EIF3G
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 3 subunit G; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre- initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termi [...]


ensembl_gene_id: A0A2U3VUD3
symbol: ASNA1
gene_biotype: protein_coding
description:
  ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion.  [...]


ensembl_gene_id: A0A2U3VUD6
symbol: RNASEH2A
gene_biotype: protein_coding
description:
  Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.


ensembl_gene_id: A0A2U3VUD7
symbol: SLC44A2
gene_biotype: protein_coding
description:
  Choline transporter-like protein 2 isoform X1; Belongs to the CTL (choline transporter-like) family.


ensembl_gene_id: A0A2U3VUG2
symbol: CACNA1A
gene_biotype: protein_coding
description:
  Voltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents.


ensembl_gene_id: A0A2U3VUG4
symbol: TRMT1
gene_biotype: protein_coding
description:
  tRNA (Guanine(26)-N(2))-dimethyltransferase isoform X1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.


ensembl_gene_id: A0A2U3VUG8
symbol: MRI1
gene_biotype: protein_coding
description:
  Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.


ensembl_gene_id: A0A2U3VUI0
symbol: PRKACA
gene_biotype: protein_coding
description:
  cAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily.


ensembl_gene_id: A0A2U3VUI3
symbol: QTRT1
gene_biotype: protein_coding
description:
  Queuine tRNA-ribosyltransferase catalytic subunit 1; Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, formi [...]


ensembl_gene_id: A0A2U3VUK2
symbol: ADGRE3
gene_biotype: protein_coding
description:
  EGF-like module-containing mucin-like hormone receptor-like 3; Belongs to the G-protein coupled receptor 2 family.


ensembl_gene_id: A0A2U3VUM6
symbol: EPO
gene_biotype: protein_coding
description:
  Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family.


ensembl_gene_id: A0A2U3VUN0
symbol: BEST2
gene_biotype: protein_coding
description:
  Bestrophin; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family.


ensembl_gene_id: A0A2U3VUP1
symbol: CARM1
gene_biotype: protein_coding
description:
  Histone-arginine methyltransferase CARM1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.


ensembl_gene_id: A0A2U3VUR9
symbol: NSUN5
gene_biotype: protein_coding
description:
  Probable 28S rRNA (Cytosine-C(5))-methyltransferase isoform X1; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.


ensembl_gene_id: A0A2U3VUU7
symbol: FIS1
gene_biotype: protein_coding
description:
  Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering.


ensembl_gene_id: A0A2U3VUX0
symbol: POR
gene_biotype: protein_coding
description:
  NADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5; In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.


ensembl_gene_id: A0A2U3VUZ6
symbol: PTH1R
gene_biotype: protein_coding
description:
  Parathyroid hormone/parathyroid hormone-related peptide receptor; Belongs to the G-protein coupled receptor 2 family.


ensembl_gene_id: A0A2U3VV20
symbol: CELSR3
gene_biotype: protein_coding
description:
  Cadherin EGF LAG seven-pass G-type receptor 3 isoform X1; Belongs to the G-protein coupled receptor 2 family.


ensembl_gene_id: A0A2U3VV53
symbol: AMT
gene_biotype: protein_coding
description:
  Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.


ensembl_gene_id: A0A2U3VV68
symbol: TCTA
gene_biotype: protein_coding
description:
  T-cell leukemia translocation-altered gene protein homolog; May be required for cellular fusion during osteoclastogenesis; Belongs to the TCTA family.


ensembl_gene_id: A0A2U3VV93
symbol: ZMYND10
gene_biotype: protein_coding
description:
  Zinc finger MYND domain-containing protein 10; Plays a role in axonemal structure organization and motility. Involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility. May act by indirectly regulating transcription of dynein proteins. Belongs to the ZMYND10 family.


ensembl_gene_id: A0A2U3VV94
symbol: SLC25A20
gene_biotype: protein_coding
description:
  Mitochondrial carnitine/acylcarnitine carrier protein; Belongs to the mitochondrial carrier (TC 2.A.29) family.


ensembl_gene_id: A0A2U3VV99
symbol: IMPDH2
gene_biotype: protein_coding
description:
  Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.


ensembl_gene_id: A0A2U3VVF1
symbol: LOC101363511
gene_biotype: protein_coding
description:
  ATP synthase-coupling factor 6, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain; Belongs to the eukaryotic ATPase subunit F6 family.


ensembl_gene_id: A0A2U3VVH2
symbol: EIF2B2
gene_biotype: protein_coding
description:
  Translation initiation factor eIF-2B subunit beta; Belongs to the eIF-2B alpha/beta/delta subunits family.


ensembl_gene_id: A0A2U3VVS0
symbol: SUCLA2
gene_biotype: protein_coding
description:
  Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.


ensembl_gene_id: A0A2U3VVS8
symbol: MTCH2
gene_biotype: protein_coding
description:
  Mitochondrial carrier homolog 2 isoform X1; Belongs to the mitochondrial carrier (TC 2.A.29) family.


ensembl_gene_id: A0A2U3VVT4
symbol: ARL8B
gene_biotype: protein_coding
description:
  ADP-ribosylation factor-like protein 8B isoform X1; Belongs to the small GTPase superfamily. Arf family.


ensembl_gene_id: A0A2U3VVT8
symbol: MED4
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 4; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.


ensembl_gene_id: A0A2U3VVV5
symbol: NDUFS3
gene_biotype: protein_coding
description:
  NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial; Belongs to the complex I 30 kDa subunit family.


ensembl_gene_id: A0A2U3VVX2
symbol: TRNT1
gene_biotype: protein_coding
description:
  CCA tRNA nucleotidyltransferase 1, mitochondrial; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.


ensembl_gene_id: A0A2U3VW15
symbol: MYO1D
gene_biotype: protein_coding
description:
  Unconventional myosin-Id; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.


ensembl_gene_id: A0A2U3VW24
symbol: RHOT1
gene_biotype: protein_coding
description:
  Mitochondrial Rho GTPase; Mitochondrial GTPase involved in mitochondrial trafficking. Belongs to the mitochondrial Rho GTPase family.


ensembl_gene_id: A0A2U3VW33
symbol: F2
gene_biotype: protein_coding
description:
  Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.


ensembl_gene_id: A0A2U3VW70
symbol: HSD17B12
gene_biotype: protein_coding
description:
  Very-long-chain 3-oxoacyl-CoA reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family.


ensembl_gene_id: A0A2U3VW77
symbol: SUPT6H
gene_biotype: protein_coding
description:
  Transcription elongation factor spt6; Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). Belongs to the SPT6 family.


ensembl_gene_id: A0A2U3VW83
symbol: CHRM4
gene_biotype: protein_coding
description:
  Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.


ensembl_gene_id: A0A2U3VWB6
symbol: OTC
gene_biotype: protein_coding
description:
  Ornithine carbamoyltransferase, mitochondrial; Belongs to the aspartate/ornithine carbamoyltransferase superfamily.


ensembl_gene_id: A0A2U3VWB7
symbol: TMEM97
gene_biotype: protein_coding
description:
  Transmembrane protein 97; Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cells. Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation. May play a role as a regulator of cellular cholesterol homeostasis. May function as sterol isomerase. May alter the activity of some cytochrome P450 proteins.


ensembl_gene_id: A0A2U3VWC7
symbol: MED14
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.


ensembl_gene_id: A0A2U3VWD0
symbol: USP9X
gene_biotype: protein_coding
description:
  Probable ubiquitin carboxyl-terminal hydrolase FAF-X isoform X1; Belongs to the peptidase C19 family.


ensembl_gene_id: A0A2U3VWE6
symbol: MPC1L
gene_biotype: protein_coding
description:
  Mitochondrial pyruvate carrier; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.


ensembl_gene_id: A0A2U3VWH5
symbol: MYO18A
gene_biotype: protein_coding
description:
  Unconventional myosin-XVIIIa isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.


ensembl_gene_id: A0A2U3VWI6
symbol: SLC25A21
gene_biotype: protein_coding
description:
  Mitochondrial 2-oxodicarboxylate carrier isoform X1; Belongs to the mitochondrial carrier (TC 2.A.29) family.


ensembl_gene_id: A0A2U3VWQ9
symbol: IL1B
gene_biotype: protein_coding
description:
  Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.


ensembl_gene_id: A0A2U3VWR2
symbol: CIAO1
gene_biotype: protein_coding
description:
  Probable cytosolic iron-sulfur protein assembly protein CIAO1; Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation; Belongs to the WD repeat CIA1 family.


ensembl_gene_id: A0A2U3VWR3
symbol: GEMIN2
gene_biotype: protein_coding
description:
  Gem-associated protein 2; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs; Belongs to the gemin-2 family.


ensembl_gene_id: A0A2U3VWT8
symbol: SRP54
gene_biotype: protein_coding
description:
  Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). Belongs to the GTP-binding SRP family. SRP54 subfamily.


ensembl_gene_id: A0A2U3VWV3
symbol: KCNG3
gene_biotype: protein_coding
description:
  Potassium voltage-gated channel subfamily G member 3 isoform X1; Belongs to the potassium channel family.


ensembl_gene_id: A0A2U3VWW0
symbol: TRPC4
gene_biotype: protein_coding
description:
  Short transient receptor potential channel 4 isoform X1; Belongs to the transient receptor (TC 1.A.4) family.


ensembl_gene_id: A0A2U3VWW1
symbol: ELOVL4
gene_biotype: protein_coding
description:
  Elongation of very long chain fatty acids protein 4; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane  [...]


ensembl_gene_id: A0A2U3VWX5
symbol: SLC20A1
gene_biotype: protein_coding
description:
  Phosphate transporter; Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport. Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.


ensembl_gene_id: A0A2U3VWZ2
symbol: UFM1
gene_biotype: protein_coding
description:
  Ubiquitin-fold modifier 1; Ubiquitin-like modifier which can be covalently attached to substrate proteins as a monomer or a lysine-linked polymer in a post- translational process called ufmylation. Ufmylation on lysine residues of proteins may play a crucial role in a number of cellular processes.


ensembl_gene_id: A0A2U3VX04
symbol: PRKD1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.


ensembl_gene_id: A0A2U3VX82
symbol: DUSP18
gene_biotype: protein_coding
description:
  Dual specificity protein phosphatase 18 isoform X1; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.


ensembl_gene_id: A0A2U3VX94
symbol: KREMEN1
gene_biotype: protein_coding
description:
  Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6.


ensembl_gene_id: A0A2U3VXA3
symbol: SLC5A1
gene_biotype: protein_coding
description:
  Sodium/glucose cotransporter 1 isoform X1; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.


ensembl_gene_id: A0A2U3VXB4
symbol: REV1
gene_biotype: protein_coding
description:
  DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family.


ensembl_gene_id: A0A2U3VXD0
symbol: PES1
gene_biotype: protein_coding
description:
  Pescadillo homolog; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the pescadillo family.


ensembl_gene_id: A0A2U3VXI7
symbol: HAAO
gene_biotype: protein_coding
description:
  3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate; Belongs to the 3-HAO family.


ensembl_gene_id: A0A2U3VXL2
symbol: SH2D1A
gene_biotype: protein_coding
description:
  SH2 domain-containing protein 1A; Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2.


ensembl_gene_id: A0A2U3VXL8
symbol: ZAP70
gene_biotype: protein_coding
description:
  Tyrosine-protein kinase ZAP-70; Belongs to the protein kinase superfamily. Tyr protein kinase family.


ensembl_gene_id: A0A2U3VXT6
symbol: NDUFA12
gene_biotype: protein_coding
description:
  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.


ensembl_gene_id: A0A2U3VXW1
symbol: METAP2
gene_biotype: protein_coding
description:
  Methionine aminopeptidase 2; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.


ensembl_gene_id: A0A2U3VXY2
symbol: ECHDC2
gene_biotype: protein_coding
description:
  enoyl-CoA hydratase domain-containing protein 2, mitochondrial isoform X1; Belongs to the enoyl-CoA hydratase/isomerase family.


ensembl_gene_id: A0A2U3VXY7
symbol: CPT2
gene_biotype: protein_coding
description:
  Carnitine O-palmitoyltransferase 2, mitochondrial; Belongs to the carnitine/choline acetyltransferase family.


ensembl_gene_id: A0A2U3VY11
symbol: EHD4
gene_biotype: protein_coding
description:
  EH domain-containing protein 4; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.


ensembl_gene_id: A0A2U3VY27
symbol: SCP2
gene_biotype: protein_coding
description:
  Non-specific lipid-transfer protein isoform X1; Belongs to the thiolase-like superfamily. Thiolase family.


ensembl_gene_id: A0A2U3VY83
symbol: MED15
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.


ensembl_gene_id: A0A2U3VY92
symbol: LOC101367253
gene_biotype: protein_coding
description:
  Tubulin alpha-3 chain-like; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.


ensembl_gene_id: A0A2U3VY98
symbol: CHAC1
gene_biotype: protein_coding
description:
  Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.


ensembl_gene_id: A0A2U3VYA8
symbol: ADSS
gene_biotype: protein_coding
description:
  Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.


ensembl_gene_id: A0A2U3VYB1
symbol: RAD51
gene_biotype: protein_coding
description:
  DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...]


ensembl_gene_id: A0A2U3VYB3
symbol: KIF26B
gene_biotype: protein_coding
description:
  Kinesin-like protein KIF26B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.


ensembl_gene_id: A0A2U3VYC2
symbol: SLC2A11
gene_biotype: protein_coding
description:
  Solute carrier family 2, facilitated glucose transporter member 11; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.


ensembl_gene_id: A0A2U3VYE9
symbol: TFB2M
gene_biotype: protein_coding
description:
  rRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.


ensembl_gene_id: A0A2U3VYI8
symbol: TOP3B
gene_biotype: protein_coding
description:
  DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.


ensembl_gene_id: A0A2U3VYJ2
symbol: SMARCB1
gene_biotype: protein_coding
description:
  SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Belongs to the SNF5 family.


ensembl_gene_id: A0A2U3VYJ9
symbol: MKNK1
gene_biotype: protein_coding
description:
  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1; Belongs to the protein kinase superfamily.


ensembl_gene_id: A0A2U3VYK3
symbol: LOC101372183
gene_biotype: protein_coding
description:
  Cytochrome b-c1 complex subunit 6; This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1. Belongs to the UQCRH/QCR6 family.


ensembl_gene_id: A0A2U3VYL3
symbol: ADORA2A
gene_biotype: protein_coding
description:
  Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.


ensembl_gene_id: A0A2U3VYN1
symbol: NSUN4
gene_biotype: protein_coding
description:
  5-methylcytosine rRNA methyltransferase NSUN4 isoform X1; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.


ensembl_gene_id: A0A2U3VYN7
symbol: MED8
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 8; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.


ensembl_gene_id: A0A2U3VYS7
symbol: ATP6V0B
gene_biotype: protein_coding
description:
  V-type proton ATPase 21 kDa proteolipid subunit isoform X1; Belongs to the V-ATPase proteolipid subunit family.


ensembl_gene_id: A0A2U3VYT3
symbol: ST3GAL3
gene_biotype: protein_coding
description:
  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X1; Belongs to the glycosyltransferase 29 family.


ensembl_gene_id: A0A2U3VYV8
symbol: VPS28
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.


ensembl_gene_id: A0A2U3VZ58
symbol: LOC101362737
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 3 subunit J; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...]


ensembl_gene_id: A0A2U3VZA3
symbol: CHM
gene_biotype: protein_coding
description:
  Rab proteins geranylgeranyltransferase component A; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane.


ensembl_gene_id: A0A2U3VZB4
symbol: EHD2
gene_biotype: protein_coding
description:
  EH domain-containing protein 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.


ensembl_gene_id: A0A2U3VZB5
symbol: ASIC1
gene_biotype: protein_coding
description:
  Acid-sensing ion channel 1 isoform X1; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.


ensembl_gene_id: A0A2U3VZF2
symbol: SLC8A2
gene_biotype: protein_coding
description:
  Sodium/calcium exchanger 2 isoform X1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.


ensembl_gene_id: A0A2U3VZF4
symbol: DHH
gene_biotype: protein_coding
description:
  Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.


ensembl_gene_id: A0A2U3VZH8
symbol: BLOC1S3
gene_biotype: protein_coding
description:
  Biogenesis of lysosome-related organelles complex 1 subunit 3; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO). Belongs to the BLOC1S3 family.


ensembl_gene_id: A0A2U3VZL4
symbol: PGLYRP1
gene_biotype: protein_coding
description:
  Peptidoglycan-recognition protein; Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Involved in innate immunity.


ensembl_gene_id: A0A2U3VZN7
symbol: VASP
gene_biotype: protein_coding
description:
  Vasodilator-stimulated phosphoprotein isoform X1; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family.


ensembl_gene_id: A0A2U3VZP9
symbol: GPC3
gene_biotype: protein_coding
description:
  Glypican-3 isoform X1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.


ensembl_gene_id: A0A2U3VZQ2
symbol: HS6ST2
gene_biotype: protein_coding
description:
  Heparan-sulfate 6-O-sulfotransferase; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.


ensembl_gene_id: A0A2U3VZR5
symbol: ATM
gene_biotype: protein_coding
description:
  Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]


ensembl_gene_id: A0A2U3VZW4
symbol: ACAT1
gene_biotype: protein_coding
description:
  acetyl-CoA acetyltransferase, mitochondrial; Belongs to the thiolase-like superfamily. Thiolase family.


ensembl_gene_id: A0A2U3VZW8
symbol: HPRT1
gene_biotype: protein_coding
description:
  Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.


ensembl_gene_id: A0A2U3VZY5
symbol: SLC2A12
gene_biotype: protein_coding
description:
  Solute carrier family 2, facilitated glucose transporter member 12; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.


ensembl_gene_id: A0A2U3W006
symbol: LOC101385288
gene_biotype: protein_coding
description:
  LOW QUALITY PROTEIN: trace amine-associated receptor 2; Belongs to the G-protein coupled receptor 1 family.


ensembl_gene_id: A0A2U3W014
symbol: SOD2
gene_biotype: protein_coding
description:
  Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.


ensembl_gene_id: A0A2U3W050
symbol: NUBP1
gene_biotype: protein_coding
description:
  Cytosolic Fe-S cluster assembly factor NUBP1; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Implicated in the regulation of centrosome duplication; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.


ensembl_gene_id: A0A2U3W060
symbol: PMM2
gene_biotype: protein_coding
description:
  Phosphomannomutase; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions.


ensembl_gene_id: A0A2U3W078
symbol: SMARCAL1
gene_biotype: protein_coding
description:
  SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.


ensembl_gene_id: A0A2U3W0B1
symbol: XRCC5
gene_biotype: protein_coding
description:
  X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family.


ensembl_gene_id: A0A2U3W0B2
symbol: KCND3
gene_biotype: protein_coding
description:
  Potassium voltage-gated channel subfamily D member 3 isoform X1; Belongs to the potassium channel family.


ensembl_gene_id: A0A2U3W0D4
symbol: EMP2
gene_biotype: protein_coding
description:
  Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family.


ensembl_gene_id: A0A2U3W0E4
symbol: ABAT
gene_biotype: protein_coding
description:
  4-aminobutyrate aminotransferase, mitochondrial; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.


ensembl_gene_id: A0A2U3W0F3
symbol: N6AMT2
gene_biotype: protein_coding
description:
  EEF1A lysine methyltransferase 1; Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'; Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.


ensembl_gene_id: A0A2U3W0J3
symbol: CAPZA1
gene_biotype: protein_coding
description:
  F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.


ensembl_gene_id: A0A2U3W0K0
symbol: SLC25A46
gene_biotype: protein_coding
description:
  Solute carrier family 25 member 46 isoform X1; Belongs to the mitochondrial carrier (TC 2.A.29) family.


ensembl_gene_id: A0A2U3W0U8
symbol: ORC4
gene_biotype: protein_coding
description:
  Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family.


ensembl_gene_id: A0A2U3W0V1
symbol: EIF4E1B
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 4E type 1B; Belongs to the eukaryotic initiation factor 4E family.


ensembl_gene_id: A0A2U3W0V6
symbol: SFT2D1
gene_biotype: protein_coding
description:
  Vesicle transport protein; May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex. Belongs to the SFT2 family.


ensembl_gene_id: A0A2U3W0W7
symbol: LOC101376724
gene_biotype: protein_coding
description:
  ATP synthase subunit d, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the cent [...]


ensembl_gene_id: A0A2U3W0Y7
symbol: IL2
gene_biotype: protein_coding
description:
  Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.


ensembl_gene_id: A0A2U3W0Z2
symbol: BBS7
gene_biotype: protein_coding
description:
  Bardet-Biedl syndrome 7 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function.


ensembl_gene_id: A0A2U3W134
symbol: GPR31
gene_biotype: protein_coding
description:
  12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor; Belongs to the G-protein coupled receptor 1 family.


ensembl_gene_id: A0A2U3W135
symbol: TRPC3
gene_biotype: protein_coding
description:
  Short transient receptor potential channel 3 isoform X2; Belongs to the transient receptor (TC 1.A.4) family.


ensembl_gene_id: A0A2U3W166
symbol: UPP1
gene_biotype: protein_coding
description:
  Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.


ensembl_gene_id: A0A2U3W174
symbol: PAN2
gene_biotype: protein_coding
description:
  PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent  [...]


ensembl_gene_id: A0A2U3W196
symbol: MYO1A
gene_biotype: protein_coding
description:
  Unconventional myosin-Ia; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.


ensembl_gene_id: A0A2U3W1G2
symbol: DDIT3
gene_biotype: protein_coding
description:
  DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...]


ensembl_gene_id: A0A2U3W1G3
symbol: ATP5B
gene_biotype: protein_coding
description:
  ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane.


ensembl_gene_id: A0A2U3W1G5
symbol: SDR9C7
gene_biotype: protein_coding
description:
  Short-chain dehydrogenase/reductase family 9C member 7; Belongs to the short-chain dehydrogenases/reductases (SDR) family.


ensembl_gene_id: A0A2U3W1G8
symbol: KIF5A
gene_biotype: protein_coding
description:
  Kinesin heavy chain isoform 5A isoform X2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.


ensembl_gene_id: A0A2U3W1K3
symbol: HSD17B6
gene_biotype: protein_coding
description:
  17-beta-hydroxysteroid dehydrogenase type 6; Belongs to the short-chain dehydrogenases/reductases (SDR) family.


ensembl_gene_id: A0A2U3W1L2
symbol: ROCK2
gene_biotype: protein_coding
description:
  Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.


ensembl_gene_id: A0A2U3W1L7
symbol: ATP6V1C2
gene_biotype: protein_coding
description:
  V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.


ensembl_gene_id: A0A2U3W1M5
symbol: TSFM
gene_biotype: protein_coding
description:
  Elongation factor Ts, mitochondrial; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family.


ensembl_gene_id: A0A2U3W1X2
symbol: POLL
gene_biotype: protein_coding
description:
  DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.


ensembl_gene_id: A0A2U3W1Z4
symbol: CENPE
gene_biotype: protein_coding
description:
  LOW QUALITY PROTEIN: centromere-associated protein E; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.


ensembl_gene_id: A0A2U3W226
symbol: HPS6
gene_biotype: protein_coding
description:
  Hermansky-Pudlak syndrome 6 protein homolog; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.


ensembl_gene_id: A0A2U3W228
symbol: LZTS2
gene_biotype: protein_coding
description:
  Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin.


ensembl_gene_id: A0A2U3W256
symbol: GMPR2
gene_biotype: protein_coding
description:
  GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.


ensembl_gene_id: A0A2U3W258
symbol: ELOVL3
gene_biotype: protein_coding
description:
  Elongation of very long chain fatty acids protein 3; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precurs [...]


ensembl_gene_id: A0A2U3W270
symbol: DCAF11
gene_biotype: protein_coding
description:
  DDB1- and CUL4-associated factor 11; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex; Belongs to the WD repeat LEC14B family.


ensembl_gene_id: A0A2U3W2C0
symbol: PRMT5
gene_biotype: protein_coding
description:
  Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily.


ensembl_gene_id: A0A2U3W2E1
symbol: CHD8
gene_biotype: protein_coding
description:
  Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...]


ensembl_gene_id: A0A2U3W2R4
symbol: SLC2A13
gene_biotype: protein_coding
description:
  Proton myo-inositol cotransporter; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.


ensembl_gene_id: A0A2U3W2R6
symbol: LOC101366299
gene_biotype: protein_coding
description:
  Glyceraldehyde-3-phosphate dehydrogenase-like; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.


ensembl_gene_id: A0A2U3W2Y6
symbol: PABPC1
gene_biotype: protein_coding
description:
  Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family.


ensembl_gene_id: A0A2U3W2Y9
symbol: RRS1
gene_biotype: protein_coding
description:
  Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family.


ensembl_gene_id: A0A2U3W351
symbol: RPS3A
gene_biotype: protein_coding
description:
  40S ribosomal protein S3a; May play a role during erythropoiesis through regulation of transcription factor DDIT3.


ensembl_gene_id: A0A2U3W390
symbol: GATB
gene_biotype: protein_coding
description:
  Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Belongs to the GatB/GatE family. GatB subfamily.


ensembl_gene_id: A0A2U3W3A5
symbol: PRIM2
gene_biotype: protein_coding
description:
  DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands.


ensembl_gene_id: A0A2U3W3A8
symbol: MND1
gene_biotype: protein_coding
description:
  Meiotic nuclear division protein 1 homolog; Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. Belongs to the MND1 family.


ensembl_gene_id: A0A2U3W3B6
symbol: F3
gene_biotype: protein_coding
description:
  Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.


ensembl_gene_id: A0A2U3W3E6
symbol: SLC26A5
gene_biotype: protein_coding
description:
  Prestin; Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ; Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.


ensembl_gene_id: A0A2U3W3K6
symbol: LOC101381565
gene_biotype: protein_coding
description:
  GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.


ensembl_gene_id: A0A2U3W3P8
symbol: ATG12
gene_biotype: protein_coding
description:
  Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.


ensembl_gene_id: A0A2U3W3R2
symbol: PPIE
gene_biotype: protein_coding
description:
  Peptidyl-prolyl cis-trans isomerase E; Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins; Belongs to the cyclophilin-type PPIase family. PPIase E subfamily.


ensembl_gene_id: A0A2U3W3R9
symbol: AGO3
gene_biotype: protein_coding
description:
  Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.


ensembl_gene_id: A0A2U3W3S8
symbol: UTP11L
gene_biotype: protein_coding
description:
  U3 small nucleolar RNA-associated protein 11; Involved in nucleolar processing of pre-18S ribosomal RNA.


ensembl_gene_id: A0A2U3W3T2
symbol: GNL2
gene_biotype: protein_coding
description:
  Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.


ensembl_gene_id: A0A2U3W3W1
symbol: AGO4
gene_biotype: protein_coding
description:
  Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.


ensembl_gene_id: A0A2U3W408
symbol: ARPC2
gene_biotype: protein_coding
description:
  Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.


ensembl_gene_id: A0A2U3W424
symbol: LOC101366786
gene_biotype: protein_coding
description:
  Ubiquitin-conjugating enzyme E2 B-like isoform X1; Belongs to the ubiquitin-conjugating enzyme family.


ensembl_gene_id: A0A2U3W441
symbol: ASIC4
gene_biotype: protein_coding
description:
  LOW QUALITY PROTEIN: acid-sensing ion channel 4; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.


ensembl_gene_id: A0A2U3W442
symbol: ATG9A
gene_biotype: protein_coding
description:
  Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.


ensembl_gene_id: A0A2U3W449
symbol: SLC26A2
gene_biotype: protein_coding
description:
  Sulfate transporter; Sulfate transporter. May play a role in endochondral bone formation; Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.


ensembl_gene_id: A0A2U3W466
symbol: INHA
gene_biotype: protein_coding
description:
  Inhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family.


ensembl_gene_id: A0A2U3W484
symbol: PDGFRB
gene_biotype: protein_coding
description:
  Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells.


ensembl_gene_id: A0A2U3W492
symbol: CSF1R
gene_biotype: protein_coding
description:
  Macrophage colony-stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.


ensembl_gene_id: A0A2U3W493
symbol: SEPSECS
gene_biotype: protein_coding
description:
  O-phosphoseryl-tRNA(Sec) selenium transferase; Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl- tRNA(Sec) required for selenoprotein biosynthesis.


ensembl_gene_id: A0A2U3W496
symbol: SOD3
gene_biotype: protein_coding
description:
  Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family.


ensembl_gene_id: A0A2U3W4A5
symbol: CAMK2A
gene_biotype: protein_coding
description:
  Calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1; Belongs to the protein kinase superfamily.


ensembl_gene_id: A0A2U3W4C2
symbol: GLRA1
gene_biotype: protein_coding
description:
  Glycine receptor subunit alpha-1 isoform X1; Belongs to the ligand-gated ion channel (TC 1.A.9) family.


ensembl_gene_id: A0A2U3W4D5
symbol: APOA1BP
gene_biotype: protein_coding
description:
  NAD(P)H-hydrate epimerase; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.


ensembl_gene_id: A0A2U3W4D8
symbol: RHBG
gene_biotype: protein_coding
description:
  Ammonium transporter Rh type B; Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.


ensembl_gene_id: A0A2U3W4H8
symbol: CRABP2
gene_biotype: protein_coding
description:
  Cellular retinoic acid-binding protein 2; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.


ensembl_gene_id: A0A2U3W4K7
symbol: SSR2
gene_biotype: protein_coding
description:
  Translocon-associated protein subunit beta; TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.


ensembl_gene_id: A0A2U3W4K9
symbol: CKS1B
gene_biotype: protein_coding
description:
  Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.


ensembl_gene_id: A0A2U3W4N4
symbol: DPM3
gene_biotype: protein_coding
description:
  Dolichol-phosphate mannosyltransferase subunit 3; Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER. Belongs to the DPM3 family.


ensembl_gene_id: A0A2U3W4Q4
symbol: HAX1
gene_biotype: protein_coding
description:
  HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools.


ensembl_gene_id: A0A2U3W4X8
symbol: LMF1
gene_biotype: protein_coding
description:
  Lipase maturation factor; Involved in the maturation of specific proteins in the endoplasmic reticulum; Belongs to the lipase maturation factor family.


ensembl_gene_id: A0A2U3W514
symbol: RPL3L
gene_biotype: protein_coding
description:
  LOW QUALITY PROTEIN: 60S ribosomal protein L3-like; Belongs to the universal ribosomal protein uL3 family.


ensembl_gene_id: A0A2U3W542
symbol: ATP6V0C
gene_biotype: protein_coding
description:
  V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.


ensembl_gene_id: A0A2U3W595
symbol: PKMYT1
gene_biotype: protein_coding
description:
  Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X2; Belongs to the protein kinase superfamily.


ensembl_gene_id: A0A2U3W597
symbol: HMOX2
gene_biotype: protein_coding
description:
  Heme oxygenase; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase.


ensembl_gene_id: A0A2U3W5A9
symbol: SEPT12
gene_biotype: protein_coding
description:
  Septin-12 isoform X1; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.


ensembl_gene_id: A0A2U3W5D4
symbol: NTHL1
gene_biotype: protein_coding
description:
  Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.


ensembl_gene_id: A0A2U3W5L5
symbol: KCNK12
gene_biotype: protein_coding
description:
  Potassium channel subfamily K member 12; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.


ensembl_gene_id: A0A2U3W5N5
symbol: PRKCE
gene_biotype: protein_coding
description:
  Protein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...]


ensembl_gene_id: A0A2U3W5Q9
symbol: LHCGR
gene_biotype: protein_coding
description:
  Lutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.


ensembl_gene_id: A0A2U3W5R2
symbol: FSHR
gene_biotype: protein_coding
description:
  Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.


ensembl_gene_id: A0A2U3W5S5
symbol: OCLN
gene_biotype: protein_coding
description:
  Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family.


ensembl_gene_id: A0A2U3W600
symbol: LOC101369742
gene_biotype: protein_coding
description:
  Unconventional myosin-VIIa-like; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.


ensembl_gene_id: A0A2U3W617
symbol: ACMSD
gene_biotype: protein_coding
description:
  2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). Belongs to the metallo-dependent hydrolases superfamily.


ensembl_gene_id: A0A2U3W622
symbol: IL16
gene_biotype: protein_coding
description:
  Pro-interleukin-16; Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.


ensembl_gene_id: A0A2U3W674
symbol: FABP7
gene_biotype: protein_coding
description:
  Fatty acid-binding protein, brain; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.


ensembl_gene_id: A0A2U3W685
symbol: CRABP1
gene_biotype: protein_coding
description:
  Cellular retinoic acid-binding protein 1; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.


ensembl_gene_id: A0A2U3W6D6
symbol: SPAST
gene_biotype: protein_coding
description:
  Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation [...]


ensembl_gene_id: A0A2U3W6E8
symbol: PHKB
gene_biotype: protein_coding
description:
  Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family.


ensembl_gene_id: A0A2U3W6I4
symbol: ELOVL2
gene_biotype: protein_coding
description:
  Elongation of very long chain fatty acids protein 2; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). May participate to the production  [...]


ensembl_gene_id: A0A2U3W6J0
symbol: AGPS
gene_biotype: protein_coding
description:
  Alkylglycerone-phosphate synthase; Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids; Belongs to the FAD-binding oxidoreductase/transferase type 4 family.


ensembl_gene_id: A0A2U3W6M7
symbol: AP2A2
gene_biotype: protein_coding
description:
  AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]


ensembl_gene_id: A0A2U3W6M9
symbol: TALDO1
gene_biotype: protein_coding
description:
  Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.


ensembl_gene_id: A0A2U3W6Q7
symbol: B4GALNT4
gene_biotype: protein_coding
description:
  Beta-1,4-N-acetylgalactosaminyltransferase; Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'- diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans.


ensembl_gene_id: A0A2U3W6R5
symbol: EBAG9
gene_biotype: protein_coding
description:
  Receptor-binding cancer antigen expressed on SiSo cells; May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases.


ensembl_gene_id: A0A2U3W6R9
symbol: INS
gene_biotype: protein_coding
description:
  Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.


ensembl_gene_id: A0A2U3W6U9
symbol: ENY2
gene_biotype: protein_coding
description:
  Transcription and mRNA export factor ENY2; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for trans [...]


ensembl_gene_id: A0A2U3W6V7
symbol: SLC5A8
gene_biotype: protein_coding
description:
  Sodium-coupled monocarboxylate transporter 1; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.


ensembl_gene_id: A0A2U3W6W1
symbol: SLC25A3
gene_biotype: protein_coding
description:
  Phosphate carrier protein, mitochondrial isoform X1; Belongs to the mitochondrial carrier (TC 2.A.29) family.


ensembl_gene_id: A0A2U3W6X3
symbol: APAF1
gene_biotype: protein_coding
description:
  Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.


ensembl_gene_id: A0A2U3W6Z2
symbol: GDAP1
gene_biotype: protein_coding
description:
  Ganglioside-induced differentiation-associated protein 1 isoform X1; Belongs to the GST superfamily.


ensembl_gene_id: A0A2U3W782
symbol: MSRB2
gene_biotype: protein_coding
description:
  Peptide-methionine (R)-S-oxide reductase; Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues.


ensembl_gene_id: A0A2U3W785
symbol: ATE1
gene_biotype: protein_coding
description:
  Arginyl-tRNA--protein transferase 1; Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Belongs to the R-transferase family.


ensembl_gene_id: A0A2U3W794
symbol: NSMCE4A
gene_biotype: protein_coding
description:
  Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.


ensembl_gene_id: A0A2U3W7D7
symbol: PPIL4
gene_biotype: protein_coding
description:
  Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.


ensembl_gene_id: A0A2U3W7F3
symbol: MYO1C
gene_biotype: protein_coding
description:
  Unconventional myosin-Ic isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.


ensembl_gene_id: A0A2U3W7I7
symbol: PAFAH1B1
gene_biotype: protein_coding
description:
  Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...]


ensembl_gene_id: A0A2U3W7J6
symbol: SEC23B
gene_biotype: protein_coding
description:
  Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily.


ensembl_gene_id: A0A2U3W7K2
symbol: DPH1
gene_biotype: protein_coding
description:
  2-(3-amino-3-carboxypropyl)histidine synthase subunit 1; Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.


ensembl_gene_id: A0A2U3W7K4
symbol: METTL16
gene_biotype: protein_coding
description:
  U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase; RNA N6-methyltransferase that methylates adenosine residues of a subset of RNAs and plays a key role in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6- methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure. In presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifical [...]


ensembl_gene_id: A0A2U3W7L1
symbol: MGME1
gene_biotype: protein_coding
description:
  Mitochondrial genome maintenance exonuclease 1; Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA- primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair; Belongs to the MGME1 family.


ensembl_gene_id: A0A2U3W7M2
symbol: LOC101377785
gene_biotype: protein_coding
description:
  ATP synthase subunit; Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proto [...]


ensembl_gene_id: A0A2U3W7R6
symbol: ENSA
gene_biotype: protein_coding
description:
  Alpha-endosulfine; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. Belongs to the endosulfine family.


ensembl_gene_id: A0A2U3W7X8
symbol: RNGTT
gene_biotype: protein_coding
description:
  Polynucleotide 5'-triphosphatase; Bifunctional mRNA-capping enzyme exhibiting RNA 5'- triphosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the gmp moiety of GTP to the 5'-diphosphate terminus.


ensembl_gene_id: A0A2U3W7Y3
symbol: GABRR1
gene_biotype: protein_coding
description:
  Gamma-aminobutyric acid receptor subunit rho-1 isoform X1; Belongs to the ligand-gated ion channel (TC 1.A.9) family.


ensembl_gene_id: A0A2U3W7Z9
symbol: MAP3K7
gene_biotype: protein_coding
description:
  Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.


ensembl_gene_id: A0A2U3W801
symbol: GABRR2
gene_biotype: protein_coding
description:
  Gamma-aminobutyric acid receptor subunit rho-2; Belongs to the ligand-gated ion channel (TC 1.A.9) family.


ensembl_gene_id: A0A2U3W820
symbol: METTL10
gene_biotype: protein_coding
description:
  EEF1A lysine methyltransferase 2; Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-318'; Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.


ensembl_gene_id: A0A2U3W831
symbol: OAT
gene_biotype: protein_coding
description:
  Ornithine aminotransferase, mitochondrial; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.


ensembl_gene_id: A0A2U3W885
symbol: MOCOS
gene_biotype: protein_coding
description:
  Molybdenum cofactor sulfurase; Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.


ensembl_gene_id: A0A2U3W8H3
symbol: HGS
gene_biotype: protein_coding
description:
  Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...]


ensembl_gene_id: A0A2U3W8L2
symbol: EIF4E3
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 4E type 3; Belongs to the eukaryotic initiation factor 4E family.


ensembl_gene_id: A0A2U3W8Q6
symbol: MYO9B
gene_biotype: protein_coding
description:
  Unconventional myosin-IXb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.


ensembl_gene_id: A0A2U3W8U3
symbol: LSM4
gene_biotype: protein_coding
description:
  U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA.


ensembl_gene_id: A0A2U3W8W9
symbol: COPE
gene_biotype: protein_coding
description:
  Coatomer subunit epsilon; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Belongs to the COPE family.


ensembl_gene_id: A0A2U3W8Y4
symbol: SLC25A42
gene_biotype: protein_coding
description:
  Mitochondrial coenzyme A transporter SLC25A42; Belongs to the mitochondrial carrier (TC 2.A.29) family.


ensembl_gene_id: A0A2U3W901
symbol: KIF15
gene_biotype: protein_coding
description:
  Kinesin-like protein KIF15; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.


ensembl_gene_id: A0A2U3W926
symbol: GABRG3
gene_biotype: protein_coding
description:
  Gamma-aminobutyric acid receptor subunit gamma-3; Belongs to the ligand-gated ion channel (TC 1.A.9) family.


ensembl_gene_id: A0A2U3W932
symbol: PTPN4
gene_biotype: protein_coding
description:
  Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton.


ensembl_gene_id: A0A2U3W945
symbol: PRMT9
gene_biotype: protein_coding
description:
  TPR_REGION domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.


ensembl_gene_id: A0A2U3W964
symbol: IL12B
gene_biotype: protein_coding
description:
  Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.


ensembl_gene_id: A0A2U3W980
symbol: THG1L
gene_biotype: protein_coding
description:
  tRNA(His) guanylyltransferase; Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage.


ensembl_gene_id: A0A2U3W997
symbol: KCNC2
gene_biotype: protein_coding
description:
  Potassium voltage-gated channel subfamily C member 2 isoform X1; Belongs to the potassium channel family.


ensembl_gene_id: A0A2U3W9B0
symbol: KRR1
gene_biotype: protein_coding
description:
  KRR1 small subunit processome component; Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.


ensembl_gene_id: A0A2U3W9F2
symbol: CDKN3
gene_biotype: protein_coding
description:
  Cyclin-dependent kinase inhibitor 3; May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues.


ensembl_gene_id: A0A2U3W9N4
symbol: ADI1
gene_biotype: protein_coding
description:
  1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Belongs to the acireductone dioxygenase (ARD) family.


ensembl_gene_id: A0A2U3W9S0
symbol: SIAH2
gene_biotype: protein_coding
description:
  E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.


ensembl_gene_id: A0A2U3W9S4
symbol: EIF2A
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 2A; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl- tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.


ensembl_gene_id: A0A2U3W9S5
symbol: SERP1
gene_biotype: protein_coding
description:
  Stress-associated endoplasmic reticulum protein; May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation. Belongs to the RAMP4 family.


ensembl_gene_id: A0A2U3WA16
symbol: SLC47A2
gene_biotype: protein_coding
description:
  Multidrug and toxin extrusion protein; Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.


ensembl_gene_id: A0A2U3WA40
symbol: MYO15A
gene_biotype: protein_coding
description:
  Unconventional myosin-XV; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.


ensembl_gene_id: A0A2U3WA58
symbol: MED9
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 9; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.


ensembl_gene_id: A0A2U3WA62
symbol: PEMT
gene_biotype: protein_coding
description:
  Phosphatidylethanolamine N-methyltransferase; Catalyzes the three sequential steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME), PMME to phosphatidyldimethylethanolamine (PDME), and PDME to phosphatidylcholine (PC); Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.


ensembl_gene_id: A0A2U3WA64
symbol: DHRS7B
gene_biotype: protein_coding
description:
  Dehydrogenase/reductase SDR family member 7B; Belongs to the short-chain dehydrogenases/reductases (SDR) family.


ensembl_gene_id: A0A2U3WA68
symbol: MAP2K3
gene_biotype: protein_coding
description:
  Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily.


ensembl_gene_id: A0A2U3WA80
symbol: NOG
gene_biotype: protein_coding
description:
  Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.


ensembl_gene_id: A0A2U3WAB4
symbol: PGRMC1
gene_biotype: protein_coding
description:
  Membrane-associated progesterone receptor component 1 isoform X1; Belongs to the cytochrome b5 family.


ensembl_gene_id: A0A2U3WAS5
symbol: PHKG1
gene_biotype: protein_coding
description:
  Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform isoform X1; Belongs to the protein kinase superfamily.


ensembl_gene_id: A0A2U3WAT4
symbol: TPST1
gene_biotype: protein_coding
description:
  Protein-tyrosine sulfotransferase; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate; Belongs to the protein sulfotransferase family.


ensembl_gene_id: A0A2U3WAT7
symbol: GUSB
gene_biotype: protein_coding
description:
  Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates; Belongs to the glycosyl hydrolase 2 family.


ensembl_gene_id: A0A2U3WAV5
symbol: CAMLG
gene_biotype: protein_coding
description:
  Calcium signal-modulating cyclophilin ligand; Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B.


ensembl_gene_id: A0A2U3WAX0
symbol: TRPC7
gene_biotype: protein_coding
description:
  Short transient receptor potential channel 7 isoform X1; Belongs to the transient receptor (TC 1.A.4) family.


ensembl_gene_id: A0A2U3WAY4
symbol: ST8SIA1
gene_biotype: protein_coding
description:
  alpha-N-acetylneuraminide alpha-2,8-sialyltransferase isoform X1; Belongs to the glycosyltransferase 29 family.


ensembl_gene_id: A0A2U3WAZ6
symbol: WDR35
gene_biotype: protein_coding
description:
  WD repeat-containing protein 35; As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis and ciliary protein trafficking.


ensembl_gene_id: A0A2U3WB06
symbol: GYS2
gene_biotype: protein_coding
description:
  Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan.


ensembl_gene_id: A0A2U3WB42
symbol: PRMT6
gene_biotype: protein_coding
description:
  Protein arginine N-methyltransferase 6; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.


ensembl_gene_id: A0A2U3WB44
symbol: SLC25A24
gene_biotype: protein_coding
description:
  Calcium-binding mitochondrial carrier protein SCaMC-1 isoform X1; Belongs to the mitochondrial carrier (TC 2.A.29) family.


ensembl_gene_id: A0A2U3WB52
symbol: PTK2
gene_biotype: protein_coding
description:
  Focal adhesion kinase 1 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family.


ensembl_gene_id: A0A2U3WB83
symbol: CKMT2
gene_biotype: protein_coding
description:
  LOW QUALITY PROTEIN: creatine kinase S-type, mitochondrial; Belongs to the ATP:guanido phosphotransferase family.


ensembl_gene_id: A0A2U3WBA6
symbol: BLOC1S5
gene_biotype: protein_coding
description:
  Biogenesis of lysosome-related organelles complex 1 subunit 5; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO).


ensembl_gene_id: A0A2U3WBB9
symbol: RIOK1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase RIO1; Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.


ensembl_gene_id: A0A2U3WBC8
symbol: SLC24A2
gene_biotype: protein_coding
description:
  Sodium/potassium/calcium exchanger 2 isoform X1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.


ensembl_gene_id: A0A2U3WBI3
symbol: TRMT1L
gene_biotype: protein_coding
description:
  TRMT1-like protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.


ensembl_gene_id: A0A2U3WBJ3
symbol: MAP2K6
gene_biotype: protein_coding
description:
  Dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily.


ensembl_gene_id: A0A2U3WBM3
symbol: KYNU
gene_biotype: protein_coding
description:
  Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family.


ensembl_gene_id: A0A2U3WBP0
symbol: HPS3
gene_biotype: protein_coding
description:
  Hermansky-Pudlak syndrome 3 protein homolog; Involved in early stages of melanosome biogenesis and maturation.


ensembl_gene_id: A0A2U3WBQ2
symbol: ST8SIA3
gene_biotype: protein_coding
description:
  sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha 2,8-sialyltransferase; Belongs to the glycosyltransferase 29 family.


ensembl_gene_id: A0A2U3WBU6
symbol: FTSJ3
gene_biotype: protein_coding
description:
  pre-rRNA processing protein FTSJ3; Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.


ensembl_gene_id: A0A2U3WC02
symbol: SETD7
gene_biotype: protein_coding
description:
  Histone-lysine N-methyltransferase SETD7; Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes.


ensembl_gene_id: A0A2U3WC13
symbol: UCP1
gene_biotype: protein_coding
description:
  Mitochondrial brown fat uncoupling protein 1 isoform X1; Belongs to the mitochondrial carrier (TC 2.A.29) family.


ensembl_gene_id: A0A2U3WC31
symbol: TNFSF13B
gene_biotype: protein_coding
description:
  Tumor necrosis factor ligand superfamily member 13B isoform X1; Belongs to the tumor necrosis factor family.


ensembl_gene_id: A0A2U3WC46
symbol: LYZ
gene_biotype: protein_coding
description:
  Lysozyme; Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Belongs to the glycosyl hydrolase 22 family.


ensembl_gene_id: A0A2U3WCA4
symbol: NMD3
gene_biotype: protein_coding
description:
  60S ribosomal export protein NMD3; Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit; Belongs to the NMD3 family.


ensembl_gene_id: A0A2U3WCB8
symbol: IL12A
gene_biotype: protein_coding
description:
  Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC.


ensembl_gene_id: A0A2U3WCC8
symbol: APIP
gene_biotype: protein_coding
description:
  Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death; Belongs to the aldolase class II family. MtnB subfamily.


ensembl_gene_id: A0A2U3WCD4
symbol: NAT10
gene_biotype: protein_coding
description:
  RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.


ensembl_gene_id: A0A2U3WCD6
symbol: CAT
gene_biotype: protein_coding
description:
  Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.


ensembl_gene_id: A0A2U3WCF5
symbol: EIF3M
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 3 subunit M; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...]


ensembl_gene_id: A0A2U3WCQ3
symbol: TARBP2
gene_biotype: protein_coding
description:
  RISC-loading complex subunit TARBP2; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from [...]


ensembl_gene_id: A0A2U3WCR3
symbol: AMHR2
gene_biotype: protein_coding
description:
  Anti-Muellerian hormone type-2 receptor; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.


ensembl_gene_id: A0A2U3WCV7
symbol: GART
gene_biotype: protein_coding
description:
  Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family.  In the central section; belongs to the AIR synthase family.


ensembl_gene_id: A0A2U3WCZ2
symbol: SEPT11
gene_biotype: protein_coding
description:
  Septin-11 isoform X1; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.


ensembl_gene_id: A0A2U3WD06
symbol: SDAD1
gene_biotype: protein_coding
description:
  Protein SDA1; Required for 60S pre-ribosomal subunits export to the cytoplasm; Belongs to the SDA1 family.


ensembl_gene_id: A0A2U3WD35
symbol: BPGM
gene_biotype: protein_coding
description:
  Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily.


ensembl_gene_id: A0A2U3WD60
symbol: FABP3
gene_biotype: protein_coding
description:
  Fatty acid-binding protein, heart; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.


ensembl_gene_id: A0A2U3WD76
symbol: EIF3I
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 3 subunit I; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...]


ensembl_gene_id: A0A2U3WDA4
symbol: AK2
gene_biotype: protein_coding
description:
  Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.


ensembl_gene_id: A0A2U3WDG2
symbol: LOC101366695
gene_biotype: protein_coding
description:
  Uncharacterized protein LOC101366695; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.


ensembl_gene_id: A0A2U3WDI8
symbol: MX1
gene_biotype: protein_coding
description:
  Interferon-induced GTP-binding protein Mx1 isoform X1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.


ensembl_gene_id: A0A2U3WDL8
symbol: MX2
gene_biotype: protein_coding
description:
  Interferon-induced GTP-binding protein Mx2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.


ensembl_gene_id: A0A2U3WDM0
symbol: CRYAA
gene_biotype: protein_coding
description:
  Alpha-crystallin A chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.


ensembl_gene_id: A0A2U3WDN0
symbol: WDR4
gene_biotype: protein_coding
description:
  tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4; Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit. Belongs to the WD repeat TRM82 family.


ensembl_gene_id: A0A2U3WDP8
symbol: MYO6
gene_biotype: protein_coding
description:
  Unconventional myosin-VI isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.


ensembl_gene_id: A0A2U3WDQ5
symbol: KATNAL1
gene_biotype: protein_coding
description:
  Katanin p60 ATPase-containing subunit A-like 1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neur [...]


ensembl_gene_id: A0A2U3WDS5
symbol: SLC2A1
gene_biotype: protein_coding
description:
  Solute carrier family 2, facilitated glucose transporter member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.


ensembl_gene_id: A0A2U3WDU0
symbol: CTPS1
gene_biotype: protein_coding
description:
  CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.


ensembl_gene_id: A0A2U3WDU3
symbol: KCNQ4
gene_biotype: protein_coding
description:
  Potassium voltage-gated channel subfamily KQT member 4 isoform X1; Belongs to the potassium channel family.


ensembl_gene_id: A0A2U3WE01
symbol: POLR2H
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.


ensembl_gene_id: A0A2U3WE24
symbol: PSMD2
gene_biotype: protein_coding
description:
  26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family.


ensembl_gene_id: A0A2U3WE31
symbol: ALG3
gene_biotype: protein_coding
description:
  Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase; Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-Dol.


ensembl_gene_id: A0A2U3WE45
symbol: LOC101381387
gene_biotype: protein_coding
description:
  LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 3E; Belongs to the ligand-gated ion channel (TC 1.A.9) family.


ensembl_gene_id: A0A2U3WE94
symbol: MYO1E
gene_biotype: protein_coding
description:
  Unconventional myosin-Ie; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.


ensembl_gene_id: A0A2U3WEH2
symbol: HSD17B10
gene_biotype: protein_coding
description:
  3-hydroxyacyl-CoA dehydrogenase type-2 isoform X1; Belongs to the short-chain dehydrogenases/reductases (SDR) family.


ensembl_gene_id: A0A2U3WEM9
symbol: LOC101382175
gene_biotype: protein_coding
description:
  Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.


ensembl_gene_id: A0A2U3WEQ2
symbol: FUT11
gene_biotype: protein_coding
description:
  Alpha-(1,3)-fucosyltransferase; Probable fucosyltransferase; Belongs to the glycosyltransferase 10 family.


ensembl_gene_id: A0A2U3WER1
symbol: DUSP13
gene_biotype: protein_coding
description:
  Dual specificity protein phosphatase 13 isoform X1; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.


ensembl_gene_id: A0A2U3WER7
symbol: DUPD1
gene_biotype: protein_coding
description:
  Dual specificity phosphatase DUPD1; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.


ensembl_gene_id: A0A2U3WEV3
symbol: COQ3
gene_biotype: protein_coding
description:
  Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.


ensembl_gene_id: A0A2U3WEX9
symbol: VMA21
gene_biotype: protein_coding
description:
  Vacuolar ATPase assembly integral membrane protein VMA21; Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum.


ensembl_gene_id: A0A2U3WEZ9
symbol: GFM1
gene_biotype: protein_coding
description:
  Elongation factor G, mitochondrial; Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mito [...]


ensembl_gene_id: A0A2U3WF20
symbol: CSF1
gene_biotype: protein_coding
description:
  Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female  [...]


ensembl_gene_id: A0A2U3WF77
symbol: NMT1
gene_biotype: protein_coding
description:
  Glycylpeptide N-tetradecanoyltransferase; Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins; Belongs to the NMT family.


ensembl_gene_id: A0A2U3WFA8
symbol: ATXN7L3
gene_biotype: protein_coding
description:
  Ataxin-7-like protein 3; Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and EN [...]


ensembl_gene_id: A0A2U3WFD9
symbol: DUSP3
gene_biotype: protein_coding
description:
  Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.


ensembl_gene_id: A0A2U3WFE2
symbol: LIN7A
gene_biotype: protein_coding
description:
  Protein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family.


ensembl_gene_id: A0A2U3WFF2
symbol: MYF5
gene_biotype: protein_coding
description:
  Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation.


ensembl_gene_id: A0A2U3WFI1
symbol: PANK4
gene_biotype: protein_coding
description:
  4'-phosphopantetheine phosphatase; May play a role in the physiological regulation of coenzyme A (CoA) intracellular levels. The phosphatase activity shows preference for normal or oxidatively damaged intermediates of 4'- phosphopantetheine, which provides strong indirect evidence that the phosphatase activity pre-empts damage in the CoA pathway.


ensembl_gene_id: A0A2U3WFI6
symbol: GABRD
gene_biotype: protein_coding
description:
  Gamma-aminobutyric acid receptor subunit delta; Belongs to the ligand-gated ion channel (TC 1.A.9) family.


ensembl_gene_id: A0A2U3WFN5
symbol: SCNN1D
gene_biotype: protein_coding
description:
  LOW QUALITY PROTEIN: amiloride-sensitive sodium channel subunit delta; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.


ensembl_gene_id: A0A2U3WFP8
symbol: HSD17B3
gene_biotype: protein_coding
description:
  Testosterone 17-beta-dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family.


ensembl_gene_id: A0A2U3WFQ8
symbol: FANCC
gene_biotype: protein_coding
description:
  Fanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1.


ensembl_gene_id: A0A2U3WFT1
symbol: NDUFS1
gene_biotype: protein_coding
description:
  NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial isoform X1; Belongs to the complex I 75 kDa subunit family.


ensembl_gene_id: A0A2U3WFZ0
symbol: DNM1L
gene_biotype: protein_coding
description:
  Dynamin-1-like protein isoform X1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.


ensembl_gene_id: A0A2U3WG34
symbol: KIF27
gene_biotype: protein_coding
description:
  Kinesin-like protein KIF27 isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.


ensembl_gene_id: A0A2U3WG54
symbol: RBP5
gene_biotype: protein_coding
description:
  Retinol-binding protein 5; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.


ensembl_gene_id: A0A2U3WG76
symbol: SLC2A3
gene_biotype: protein_coding
description:
  Solute carrier family 2, facilitated glucose transporter member 3; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.


ensembl_gene_id: A0A2U3WG91
symbol: SLC25A12
gene_biotype: protein_coding
description:
  Calcium-binding mitochondrial carrier protein Aralar1 isoform X1; Belongs to the mitochondrial carrier (TC 2.A.29) family.


ensembl_gene_id: A0A2U3WG96
symbol: HAT1
gene_biotype: protein_coding
description:
  Histone acetyltransferase type B catalytic subunit; Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG.


ensembl_gene_id: A0A2U3WGP4
symbol: LOC101384815
gene_biotype: protein_coding
description:
  Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...]


ensembl_gene_id: A0A2U3WGR7
symbol: PIGM
gene_biotype: protein_coding
description:
  GPI mannosyltransferase 1; Mannosyltransferase involved in glycosylphosphatidylinositol- anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN- acyl-PI during GPI precursor assembly.


ensembl_gene_id: A0A2U3WGT0
symbol: CASQ1
gene_biotype: protein_coding
description:
  Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.


ensembl_gene_id: A0A2U3WGT7
symbol: COPA
gene_biotype: protein_coding
description:
  Coatomer subunit alpha; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.


ensembl_gene_id: A0A2U3WGV8
symbol: PPOX
gene_biotype: protein_coding
description:
  Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.


ensembl_gene_id: A0A2U3WGW3
symbol: NDUFS2
gene_biotype: protein_coding
description:
  NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial isoform X1; Belongs to the complex I 49 kDa subunit family.


ensembl_gene_id: A0A2U3WGX0
symbol: UFC1
gene_biotype: protein_coding
description:
  Ubiquitin-fold modifier-conjugating enzyme 1; E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage.


ensembl_gene_id: A0A2U3WH25
symbol: PGM3
gene_biotype: protein_coding
description:
  Phosphoacetylglucosamine mutase; Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O- glycosylation; Belongs to the phosphohexose mutase family.


ensembl_gene_id: A0A2U3WH39
symbol: ZRANB2
gene_biotype: protein_coding
description:
  Zinc finger Ran-binding domain-containing protein 2; May interfere with constitutive 5'-splice site selection. Belongs to the ZRANB2 family.


ensembl_gene_id: A0A2U3WH66
symbol: POLE2
gene_biotype: protein_coding
description:
  DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family.


ensembl_gene_id: A0A2U3WH73
symbol: DNAAF2
gene_biotype: protein_coding
description:
  Protein kintoun; Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment.


ensembl_gene_id: A0A2U3WHA0
symbol: MED20
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 20; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.


ensembl_gene_id: A0A2U3WHE0
symbol: DNPH1
gene_biotype: protein_coding
description:
  2'-deoxynucleoside 5'-phosphate N-hydrolase 1; Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'-monophosphates containing purine bases are preferred to those containing pyrimidine bases.


ensembl_gene_id: A0A2U3WHI9
symbol: AARS2
gene_biotype: protein_coding
description:
  alanine--tRNA ligase, mitochondrial; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family.


ensembl_gene_id: A0A2U3WHS5
symbol: IL4
gene_biotype: protein_coding
description:
  Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family.


ensembl_gene_id: A0A2U3WHS6
symbol: IL5
gene_biotype: protein_coding
description:
  Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells.


ensembl_gene_id: A0A2U3WHU4
symbol: SEPT8
gene_biotype: protein_coding
description:
  Septin-8 isoform X1; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.


ensembl_gene_id: A0A2U3WHV1
symbol: GSR
gene_biotype: protein_coding
description:
  Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.


ensembl_gene_id: A0A2U3WHV2
symbol: GTF2E2
gene_biotype: protein_coding
description:
  Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.


ensembl_gene_id: A0A2U3WHY5
symbol: DUSP27
gene_biotype: protein_coding
description:
  Inactive dual specificity phosphatase 27; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.


ensembl_gene_id: A0A2U3WI11
symbol: MYO10
gene_biotype: protein_coding
description:
  Unconventional myosin-X; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.


ensembl_gene_id: A0A2U3WI12
symbol: DUSP10
gene_biotype: protein_coding
description:
  Dual specificity protein phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.


ensembl_gene_id: A0A2U3WI22
symbol: TMCO1
gene_biotype: protein_coding
description:
  Calcium load-activated calcium channel; Calcium-selective channel required to prevent calcium stores from overfilling; Belongs to the TMCO1 family.


ensembl_gene_id: A0A2U3WI29
symbol: LOC101377045
gene_biotype: protein_coding
description:
  Docosahexaenoic acid omega-hydroxylase CYP4F3-like isoform X2; Belongs to the cytochrome P450 family.


ensembl_gene_id: A0A2U3WI47
symbol: LOC101362359
gene_biotype: protein_coding
description:
  Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.


ensembl_gene_id: A0A2U3WI83
symbol: SLC25A27
gene_biotype: protein_coding
description:
  Mitochondrial uncoupling protein 4 isoform X2; Belongs to the mitochondrial carrier (TC 2.A.29) family.


ensembl_gene_id: A0A2U3WIB0
symbol: PSMG2
gene_biotype: protein_coding
description:
  Proteasome assembly chaperone 2; Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. Belongs to the PSMG2 family.


ensembl_gene_id: A0A2U3WIB3
symbol: LSM8
gene_biotype: protein_coding
description:
  U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.


ensembl_gene_id: A0A2U3WIB9
symbol: CFTR
gene_biotype: protein_coding
description:
  Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.


ensembl_gene_id: A0A2U3WID2
symbol: CAV2
gene_biotype: protein_coding
description:
  Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.


ensembl_gene_id: A0A2U3WIH7
symbol: KATNAL2
gene_biotype: protein_coding
description:
  Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.


ensembl_gene_id: A0A2U3WII6
symbol: ATP5A1
gene_biotype: protein_coding
description:
  ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane.


ensembl_gene_id: A0A2U3WIK0
symbol: GTF2F2
gene_biotype: protein_coding
description:
  General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity.


ensembl_gene_id: A0A2U3WIN3
symbol: LOC101380029
gene_biotype: protein_coding
description:
  Mitochondrial import inner membrane translocase subunit TIM23; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.


ensembl_gene_id: A0A2U3WIU7
symbol: BDNF
gene_biotype: protein_coding
description:
  Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.


ensembl_gene_id: A0A2U3WIV3
symbol: BLOC1S6
gene_biotype: protein_coding
description:
  Biogenesis of lysosome-related organelles complex 1 subunit 6; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particular [...]


ensembl_gene_id: A0A2U3WIV9
symbol: SULF1
gene_biotype: protein_coding
description:
  Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family.


ensembl_gene_id: A0A2U3WIX6
symbol: TRPA1
gene_biotype: protein_coding
description:
  Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family.


ensembl_gene_id: A0A2U3WJ08
symbol: ELOVL7
gene_biotype: protein_coding
description:
  Elongation of very long chain fatty acids protein 7; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0 [...]


ensembl_gene_id: A0A2U3WJD2
symbol: SELL
gene_biotype: protein_coding
description:
  L-selectin; Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia.


ensembl_gene_id: A0A2U3WJF7
symbol: MYO7B
gene_biotype: protein_coding
description:
  Unconventional myosin-VIIb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.


ensembl_gene_id: A0A2U3WJG0
symbol: GPR17
gene_biotype: protein_coding
description:
  Uracil nucleotide/cysteinyl leukotriene receptor; Belongs to the G-protein coupled receptor 1 family.


ensembl_gene_id: A0A2U3WJM3
symbol: OLA1
gene_biotype: protein_coding
description:
  Obg-like ATPase 1; Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.


ensembl_gene_id: A0A2U3WJR2
symbol: AQR
gene_biotype: protein_coding
description:
  RNA helicase aquarius; Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre- mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing.


ensembl_gene_id: A0A2U3WJR9
symbol: DPH6
gene_biotype: protein_coding
description:
  Diphthine--ammonia ligase; Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP.


ensembl_gene_id: A0A2U3WJS7
symbol: GTF2H4
gene_biotype: protein_coding
description:
  General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family.


ensembl_gene_id: A0A2U3WJU7
symbol: ATAT1
gene_biotype: protein_coding
description:
  Alpha-tubulin N-acetyltransferase 1; Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dyn [...]


ensembl_gene_id: A0A2U3WK03
symbol: CDC123
gene_biotype: protein_coding
description:
  Cell division cycle protein 123 homolog; Required for S phase entry of the cell cycle. Belongs to the CDC123 family.


ensembl_gene_id: A0A2U3WK17
symbol: OXCT1
gene_biotype: protein_coding
description:
  Succinyl-CoA:3-ketoacid-coenzyme A transferase; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.


ensembl_gene_id: A0A2U3WK48
symbol: AVPR2
gene_biotype: protein_coding
description:
  Vasopressin V2 receptor; Involved in renal water reabsorption. Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.


ensembl_gene_id: A0A2U3WK53
symbol: MECP2
gene_biotype: protein_coding
description:
  Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).


ensembl_gene_id: A0A2U3WK69
symbol: DPYD
gene_biotype: protein_coding
description:
  Dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine; Belongs to the dihydropyrimidine dehydrogenase family.


ensembl_gene_id: A0A2U3WKB8
symbol: SSRP1
gene_biotype: protein_coding
description:
  FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...]


ensembl_gene_id: A0A2U3WKC3
symbol: UBE2L6
gene_biotype: protein_coding
description:
  ubiquitin/ISG15-conjugating enzyme E2 L6 isoform X1; Belongs to the ubiquitin-conjugating enzyme family.


ensembl_gene_id: A0A2U3WKD3
symbol: MED19
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 19; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.


ensembl_gene_id: A0A2U3WKF5
symbol: UGT8
gene_biotype: protein_coding
description:
  2-hydroxyacylsphingosine 1-beta-galactosyltransferase; Belongs to the UDP-glycosyltransferase family.


ensembl_gene_id: A0A2U3WKH1
symbol: CLP1
gene_biotype: protein_coding
description:
  Polyribonucleotide 5'-hydroxyl-kinase Clp1; Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; thi [...]


ensembl_gene_id: A0A2U3WKH9
symbol: RAG1
gene_biotype: protein_coding
description:
  V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break  [...]


ensembl_gene_id: A0A2U3WKK9
symbol: FNTB
gene_biotype: protein_coding
description:
  Protein farnesyltransferase subunit beta; Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X.


ensembl_gene_id: A0A2U3WKM2
symbol: SLC24A1
gene_biotype: protein_coding
description:
  Sodium/potassium/calcium exchanger 1 isoform X1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.


ensembl_gene_id: A0A2U3WL10
symbol: CACNG7
gene_biotype: protein_coding
description:
  Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.


ensembl_gene_id: A0A2U3WL25
symbol: CACNG8
gene_biotype: protein_coding
description:
  Voltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.


ensembl_gene_id: A0A2U3WL38
symbol: EHD3
gene_biotype: protein_coding
description:
  EH domain-containing protein 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.


ensembl_gene_id: A0A2U3WL53
symbol: MYO16
gene_biotype: protein_coding
description:
  Unconventional myosin-XVI; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.


ensembl_gene_id: A0A2U3WL61
symbol: CACNG6
gene_biotype: protein_coding
description:
  Voltage-dependent calcium channel gamma-6 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.


ensembl_gene_id: A0A2U3WL96
symbol: CPT1B
gene_biotype: protein_coding
description:
  Carnitine O-palmitoyltransferase 1, muscle isoform isoform X1; Belongs to the carnitine/choline acetyltransferase family.


ensembl_gene_id: A0A2U3WLA0
symbol: CARKD
gene_biotype: protein_coding
description:
  ATP-dependent (S)-NAD(P)H-hydrate dehydratase; Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S-and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Belongs to the NnrD/CARKD family.


ensembl_gene_id: A0A2U3WLB4
symbol: PANX2
gene_biotype: protein_coding
description:
  Pannexin; Structural component of the gap junctions and the hemichannels; Belongs to the pannexin family.


ensembl_gene_id: A0A2U3WLD5
symbol: PTEN
gene_biotype: protein_coding
description:
  Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.


ensembl_gene_id: A0A2U3WLE1
symbol: MINPP1
gene_biotype: protein_coding
description:
  Multiple inositol polyphosphate phosphatase 1 isoform X1; Belongs to the histidine acid phosphatase family.


ensembl_gene_id: A0A2U3WLG1
symbol: FAXDC2
gene_biotype: protein_coding
description:
  LOW QUALITY PROTEIN: fatty acid hydroxylase domain-containing protein 2; Belongs to the sterol desaturase family.


ensembl_gene_id: A0A2U3WLG9
symbol: SLC44A1
gene_biotype: protein_coding
description:
  Choline transporter-like protein 1 isoform X1; Belongs to the CTL (choline transporter-like) family.


ensembl_gene_id: A0A2U3WLI1
symbol: FAN1
gene_biotype: protein_coding
description:
  Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family.


ensembl_gene_id: A0A2U3WLI4
symbol: MPHOSPH10
gene_biotype: protein_coding
description:
  U3 small nucleolar ribonucleoprotein protein MPP10; Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing; Belongs to the MPP10 family.


ensembl_gene_id: A0A2U3WLK5
symbol: RNF8
gene_biotype: protein_coding
description:
  E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...]


ensembl_gene_id: A0A2U3WLL1
symbol: MTCH1
gene_biotype: protein_coding
description:
  Mitochondrial carrier homolog 1 isoform X1; Belongs to the mitochondrial carrier (TC 2.A.29) family.


ensembl_gene_id: A0A2U3WLQ3
symbol: ROR2
gene_biotype: protein_coding
description:
  Tyrosine-protein kinase transmembrane receptor ROR2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.


ensembl_gene_id: A0A2U3WLQ5
symbol: NFIL3
gene_biotype: protein_coding
description:
  Nuclear factor interleukin-3-regulated protein; Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts. Represses transcriptional activity of PER1. Represses transcriptional activity of PER2 via the B-site on the promoter. Activates transcription from the interleukin-3 promoter in T- cells. Competes for the same consensus-binding site with PAR DNA- bi [...]


ensembl_gene_id: A0A2U3WLV1
symbol: NOSIP
gene_biotype: protein_coding
description:
  Nitric oxide synthase-interacting protein; Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity; Belongs to the NOSIP family.


ensembl_gene_id: A0A2U3WLV4
symbol: AUH
gene_biotype: protein_coding
description:
  methylglutaconyl-CoA hydratase, mitochondrial isoform X1; Belongs to the enoyl-CoA hydratase/isomerase family.


ensembl_gene_id: A0A2U3WLW1
symbol: CPT1C
gene_biotype: protein_coding
description:
  Carnitine O-palmitoyltransferase 1, brain isoform isoform X1; Belongs to the carnitine/choline acetyltransferase family.


ensembl_gene_id: A0A2U3WM10
symbol: PRMT1
gene_biotype: protein_coding
description:
  Protein arginine N-methyltransferase 1 isoform X1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.


ensembl_gene_id: A0A2U3WM43
symbol: NDUFAF7
gene_biotype: protein_coding
description:
  Protein arginine methyltransferase NDUFAF7; Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).


ensembl_gene_id: A0A2U3WM77
symbol: LIM2
gene_biotype: protein_coding
description:
  Lens fiber membrane intrinsic protein; Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis; Belongs to the PMP-22/EMP/MP20 family.


ensembl_gene_id: A0A2U3WM99
symbol: FEN1
gene_biotype: protein_coding
description:
  Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as  [...]


ensembl_gene_id: A0A2U3WMC3
symbol: ATP6V1H
gene_biotype: protein_coding
description:
  V-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system.


ensembl_gene_id: A0A2U3WMF7
symbol: KCNQ2
gene_biotype: protein_coding
description:
  Potassium voltage-gated channel subfamily KQT member 2 isoform X1; Belongs to the potassium channel family.


ensembl_gene_id: A0A2U3WMG1
symbol: SDHAF2
gene_biotype: protein_coding
description:
  Succinate dehydrogenase assembly factor 2, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer.


ensembl_gene_id: A0A2U3WMK5
symbol: SLC25A13
gene_biotype: protein_coding
description:
  Calcium-binding mitochondrial carrier protein Aralar2; Belongs to the mitochondrial carrier (TC 2.A.29) family.


ensembl_gene_id: A0A2U3WMK9
symbol: EEF1A2
gene_biotype: protein_coding
description:
  Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis.


ensembl_gene_id: A0A2U3WMN9
symbol: KIF20B
gene_biotype: protein_coding
description:
  Kinesin-like protein KIF20B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.


ensembl_gene_id: A0A2U3WMS7
symbol: PDE7B
gene_biotype: protein_coding
description:
  cAMP-specific 3',5'-cyclic phosphodiesterase 7B; Belongs to the cyclic nucleotide phosphodiesterase family.


ensembl_gene_id: A0A2U3WMV2
symbol: COQ7
gene_biotype: protein_coding
description:
  5-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone- independent manner.


ensembl_gene_id: A0A2U3WN02
symbol: PTPN11
gene_biotype: protein_coding
description:
  Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.


ensembl_gene_id: A0A2U3WN29
symbol: PIGK
gene_biotype: protein_coding
description:
  GPI-anchor transamidase; Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein. Belongs to the peptidase C13 family.


ensembl_gene_id: A0A2U3WN35
symbol: ST6GALNAC5
gene_biotype: protein_coding
description:
  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; Belongs to the glycosyltransferase 29 family.


ensembl_gene_id: A0A2U3WN48
symbol: GLRA2
gene_biotype: protein_coding
description:
  Glycine receptor subunit alpha-2 isoform X2; Belongs to the ligand-gated ion channel (TC 1.A.9) family.


ensembl_gene_id: A0A2U3WN94
symbol: LOC101381490
gene_biotype: protein_coding
description:
  Ubiquitin-conjugating enzyme E2 L3-like isoform X1; Belongs to the ubiquitin-conjugating enzyme family.


ensembl_gene_id: A0A2U3WNC9
symbol: CNP
gene_biotype: protein_coding
description:
  2',3'-cyclic-nucleotide 3'-phosphodiesterase; May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin; Belongs to the 2H phosphoesterase superfamily. CNPase family.


ensembl_gene_id: A0A2U3WNE3
symbol: HCRT
gene_biotype: protein_coding
description:
  Orexin; Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Belongs to the orexin family.


ensembl_gene_id: A0A2U3WNF5
symbol: HSD17B1
gene_biotype: protein_coding
description:
  Estradiol 17-beta-dehydrogenase 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family.


ensembl_gene_id: A0A2U3WNF9
symbol: LOC101378199
gene_biotype: protein_coding
description:
  Tubulin gamma chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome.


ensembl_gene_id: A0A2U3WNH1
symbol: CD40LG
gene_biotype: protein_coding
description:
  CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.


ensembl_gene_id: A0A2U3WNS5
symbol: ELOVL5
gene_biotype: protein_coding
description:
  Elongation of very long chain fatty acids protein 5; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involv [...]


ensembl_gene_id: A0A2U3WNT8
symbol: AGPAT2
gene_biotype: protein_coding
description:
  1-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.


ensembl_gene_id: A0A2U3WP08
symbol: EIF3L
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 3 subunit L; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...]


ensembl_gene_id: A0A2U3WP41
symbol: RABGGTB
gene_biotype: protein_coding
description:
  Geranylgeranyl transferase type-2 subunit beta; Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C- terminal sequence -XXCC, -XCXC and -CCXX.


ensembl_gene_id: A0A2U3WPE1
symbol: PELO
gene_biotype: protein_coding
description:
  Protein pelota homolog; May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs.


ensembl_gene_id: A0A2U3WPF4
symbol: KIF11
gene_biotype: protein_coding
description:
  Kinesin-like protein KIF11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.


ensembl_gene_id: A0A2U3WPG1
symbol: PPP1R3C
gene_biotype: protein_coding
description:
  Protein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown.


ensembl_gene_id: A0A2U3WPI0
symbol: CROT
gene_biotype: protein_coding
description:
  Peroxisomal carnitine O-octanoyltransferase; Belongs to the carnitine/choline acetyltransferase family.


ensembl_gene_id: A0A2U3WPM3
symbol: MOCS2
gene_biotype: protein_coding
description:
  Molybdopterin synthase catalytic subunit; Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group; Belongs to the MoaE family. MOCS2B subfamily.


ensembl_gene_id: A0A2U3WPM5
symbol: LRP6
gene_biotype: protein_coding
description:
  Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.


ensembl_gene_id: A0A2U3WPR7
symbol: CRHR1
gene_biotype: protein_coding
description:
  Corticotropin-releasing factor receptor 1 isoform X1; Belongs to the G-protein coupled receptor 2 family.


ensembl_gene_id: A0A2U3WPT1
symbol: RBP7
gene_biotype: protein_coding
description:
  Retinoid-binding protein 7; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.


ensembl_gene_id: A0A2U3WPT4
symbol: PGD
gene_biotype: protein_coding
description:
  6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.


ensembl_gene_id: A0A2U3WPV2
symbol: DRAXIN
gene_biotype: protein_coding
description:
  Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway.


ensembl_gene_id: A0A2U3WPW6
symbol: BHMT
gene_biotype: protein_coding
description:
  Betaine--homocysteine S-methyltransferase 1 isoform X1; Involved in the regulation of homocysteine metabolism.


ensembl_gene_id: A0A2U3WQ25
symbol: ETNPPL
gene_biotype: protein_coding
description:
  Ethanolamine-phosphate phospho-lyase isoform X1; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.


ensembl_gene_id: A0A2U3WQ36
symbol: GAR1
gene_biotype: protein_coding
description:
  H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine (psi) residues may serve to stabilize the conformation of rRNAs.


ensembl_gene_id: A0A2U3WQ39
symbol: RRH
gene_biotype: protein_coding
description:
  LOW QUALITY PROTEIN: visual pigment-like receptor peropsin; Belongs to the G-protein coupled receptor 1 family.


ensembl_gene_id: A0A2U3WQ52
symbol: BHMT2
gene_biotype: protein_coding
description:
  S-methylmethionine--homocysteine S-methyltransferase BHMT2 isoform X1; Involved in the regulation of homocysteine metabolism.


ensembl_gene_id: A0A2U3WQC2
symbol: ELOVL6
gene_biotype: protein_coding
description:
  Elongation of very long chain fatty acids protein 6; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degre [...]


ensembl_gene_id: A0A2U3WQE5
symbol: SLC2A6
gene_biotype: protein_coding
description:
  Solute carrier family 2, facilitated glucose transporter member 6 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.


ensembl_gene_id: A0A2U3WQH3
symbol: WDR76
gene_biotype: protein_coding
description:
  WD repeat-containing protein 76; Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. Belongs to the WD repeat DDB2/WDR76 family.


ensembl_gene_id: A0A2U3WQJ1
symbol: LOC101376374
gene_biotype: protein_coding
description:
  Creatine kinase U-type, mitochondrial isoform X1; Belongs to the ATP:guanido phosphotransferase family.


ensembl_gene_id: A0A2U3WQJ8
symbol: ACTR8
gene_biotype: protein_coding
description:
  Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily.


ensembl_gene_id: A0A2U3WQL2
symbol: PSMG1
gene_biotype: protein_coding
description:
  Proteasome assembly chaperone 1; Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with psmg2.


ensembl_gene_id: A0A2U3WQP6
symbol: DUSP21
gene_biotype: protein_coding
description:
  Dual specificity protein phosphatase 21 isoform X1; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.


ensembl_gene_id: A0A2U3WQU6
symbol: RFT1
gene_biotype: protein_coding
description:
  Protein RFT1 homolog; May be involved in N-linked oligosaccharide assembly. Belongs to the RFT1 family.


ensembl_gene_id: A0A2U3WQV6
symbol: NDUFA8
gene_biotype: protein_coding
description:
  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.


ensembl_gene_id: A0A2U3WR18
symbol: TERT
gene_biotype: protein_coding
description:
  Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...]


ensembl_gene_id: A0A2U3WR20
symbol: NDUFS6
gene_biotype: protein_coding
description:
  NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.


ensembl_gene_id: A0A2U3WR23
symbol: KCNK5
gene_biotype: protein_coding
description:
  Potassium channel subfamily K member 5; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.


ensembl_gene_id: A0A2U3WR41
symbol: PTK2B
gene_biotype: protein_coding
description:
  Protein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family.


ensembl_gene_id: A0A2U3WR46
symbol: CLU
gene_biotype: protein_coding
description:
  Clusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins.


ensembl_gene_id: A0A2U3WR60
symbol: ELP3
gene_biotype: protein_coding
description:
  Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation.


ensembl_gene_id: A0A2U3WR63
symbol: CDA
gene_biotype: protein_coding
description:
  Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.


ensembl_gene_id: A0A2U3WR66
symbol: KIF17
gene_biotype: protein_coding
description:
  LOW QUALITY PROTEIN: kinesin-like protein KIF17; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.


ensembl_gene_id: A0A2U3WRA3
symbol: RARS2
gene_biotype: protein_coding
description:
  Probable arginine--tRNA ligase, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family.


ensembl_gene_id: A0A2U3WRC6
symbol: ANAPC10
gene_biotype: protein_coding
description:
  Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle.


ensembl_gene_id: A0A2U3WRD3
symbol: SCARA5
gene_biotype: protein_coding
description:
  Scavenger receptor class A member 5; Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non- transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the de [...]


ensembl_gene_id: A0A2U3WRE8
symbol: DDOST
gene_biotype: protein_coding
description:
  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across t [...]


ensembl_gene_id: A0A2U3WRH1
symbol: GDI2
gene_biotype: protein_coding
description:
  Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family.


ensembl_gene_id: A0A2U3WRK3
symbol: AK4
gene_biotype: protein_coding
description:
  Adenylate kinase 4, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity.


ensembl_gene_id: A0A2U3WRL0
symbol: MNAT1
gene_biotype: protein_coding
description:
  CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex.


ensembl_gene_id: A0A2U3WRL3
symbol: PRKCH
gene_biotype: protein_coding
description:
  Protein kinase C eta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentia [...]


ensembl_gene_id: A0A2U3WRP4
symbol: SLC26A4
gene_biotype: protein_coding
description:
  Pendrin; Sodium-independent transporter of chloride and iodide. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.


ensembl_gene_id: A0A2U3WRQ1
symbol: SLC26A3
gene_biotype: protein_coding
description:
  Chloride anion exchanger; Chloride/bicarbonate exchanger. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.


ensembl_gene_id: A0A2U3WRQ6
symbol: DUS4L
gene_biotype: protein_coding
description:
  tRNA-dihydrouridine synthase; Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs; Belongs to the dus family.


ensembl_gene_id: A0A2U3WRR0
symbol: PIK3CG
gene_biotype: protein_coding
description:
  Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1; Belongs to the PI3/PI4-kinase family.


ensembl_gene_id: A0A2U3WRT1
symbol: PRMT8
gene_biotype: protein_coding
description:
  Protein arginine N-methyltransferase 8; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.


ensembl_gene_id: A0A2U3WRV1
symbol: TOP1
gene_biotype: protein_coding
description:
  DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]


ensembl_gene_id: A0A2U3WS64
symbol: ENTPD3
gene_biotype: protein_coding
description:
  Ectonucleoside triphosphate diphosphohydrolase 3 isoform X1; Belongs to the GDA1/CD39 NTPase family.


ensembl_gene_id: A0A2U3WS74
symbol: TRPV3
gene_biotype: protein_coding
description:
  Transient receptor potential cation channel subfamily V member 3; Belongs to the transient receptor (TC 1.A.4) family.


ensembl_gene_id: A0A2U3WS77
symbol: SLC25A38
gene_biotype: protein_coding
description:
  Mitochondrial glycine transporter; Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix. Required during erythropoiesis. Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.


ensembl_gene_id: A0A2U3WS84
symbol: MYO1F
gene_biotype: protein_coding
description:
  Unconventional myosin-If; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.


ensembl_gene_id: A0A2U3WS86
symbol: TRPV1
gene_biotype: protein_coding
description:
  Transient receptor potential cation channel subfamily V member 1 isoform X1; Belongs to the transient receptor (TC 1.A.4) family.


ensembl_gene_id: A0A2U3WSA9
symbol: TRAPPC5
gene_biotype: protein_coding
description:
  Trafficking protein particle complex subunit 5; May play a role in vesicular transport from endoplasmic reticulum to Golgi.


ensembl_gene_id: A0A2U3WSB8
symbol: TIMM44
gene_biotype: protein_coding
description:
  Mitochondrial import inner membrane translocase subunit TIM44; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the Tim44 family.


ensembl_gene_id: A0A2U3WSF9
symbol: MOG
gene_biotype: protein_coding
description:
  Myelin-oligodendrocyte glycoprotein; Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. Mediates homophilic cell-cell adhesion. Belongs to the immunoglobulin superfamily. BTN/MOG family.


ensembl_gene_id: A0A2U3WSI3
symbol: MAP2K5
gene_biotype: protein_coding
description:
  Dual specificity mitogen-activated protein kinase kinase 5 isoform X1; Belongs to the protein kinase superfamily.


ensembl_gene_id: A0A2U3WSN8
symbol: ACAA1
gene_biotype: protein_coding
description:
  3-ketoacyl-CoA thiolase, peroxisomal isoform X1; Belongs to the thiolase-like superfamily. Thiolase family.


ensembl_gene_id: A0A2U3WSQ4
symbol: MYD88
gene_biotype: protein_coding
description:
  Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.


ensembl_gene_id: A0A2U3WST2
symbol: RPLP1
gene_biotype: protein_coding
description:
  60S acidic ribosomal protein P1 isoform X1; Belongs to the eukaryotic ribosomal protein P1/P2 family.


ensembl_gene_id: A0A2U3WSV7
symbol: TNFRSF11B
gene_biotype: protein_coding
description:
  Tumor necrosis factor receptor superfamily member 11B; Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis.


ensembl_gene_id: A0A2U3WSW2
symbol: PDHB
gene_biotype: protein_coding
description:
  Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.


ensembl_gene_id: A0A2U3WSY2
symbol: BCAT1
gene_biotype: protein_coding
description:
  Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.


ensembl_gene_id: A0A2U3WT02
symbol: FASLG
gene_biotype: protein_coding
description:
  Tumor necrosis factor ligand superfamily member 6 isoform X1; Belongs to the tumor necrosis factor family.


ensembl_gene_id: A0A2U3WT11
symbol: MYO18B
gene_biotype: protein_coding
description:
  Unconventional myosin-XVIIIb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.


ensembl_gene_id: A0A2U3WT56
symbol: DPM1
gene_biotype: protein_coding
description:
  Dolichol-phosphate mannosyltransferase subunit 1; Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.


ensembl_gene_id: A0A2U3WT65
symbol: MOCS3
gene_biotype: protein_coding
description:
  Adenylyltransferase and sulfurtransferase MOCS3; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl- adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (- COSH) of their C-terminus. The reaction probably involves hydrogen sulfide [...]


ensembl_gene_id: A0A2U3WTA3
symbol: TFIP11
gene_biotype: protein_coding
description:
  Tuftelin-interacting protein 11; Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP- containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extrac [...]


ensembl_gene_id: A0A2U3WTE5
symbol: VPS11
gene_biotype: protein_coding
description:
  Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS11 family.


ensembl_gene_id: A0A2U3WTG9
symbol: ARCN1
gene_biotype: protein_coding
description:
  Coatomer subunit delta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.


ensembl_gene_id: A0A2U3WTH9
symbol: KMT2A
gene_biotype: protein_coding
description:
  Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily.


ensembl_gene_id: A0A2U3WTL4
symbol: FLT4
gene_biotype: protein_coding
description:
  Vascular endothelial growth factor receptor 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.


ensembl_gene_id: A0A2U3WTM8
symbol: KIF1A
gene_biotype: protein_coding
description:
  Kinesin-like protein KIF1A; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.


ensembl_gene_id: A0A2U3WTN0
symbol: GABRA3
gene_biotype: protein_coding
description:
  Gamma-aminobutyric acid receptor subunit alpha-3; Belongs to the ligand-gated ion channel (TC 1.A.9) family.


ensembl_gene_id: A0A2U3WTY0
symbol: SEPT2
gene_biotype: protein_coding
description:
  Septin-2; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.


ensembl_gene_id: A0A2U3WU78
symbol: AGXT2
gene_biotype: protein_coding
description:
  Alanine--glyoxylate aminotransferase 2, mitochondrial isoform X1; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.


ensembl_gene_id: A0A2U3WU89
symbol: DSG3
gene_biotype: protein_coding
description:
  Desmoglein-3; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.


ensembl_gene_id: A0A2U3WU90
symbol: DSG1
gene_biotype: protein_coding
description:
  Desmoglein-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.


ensembl_gene_id: A0A2U3WU95
symbol: DSG4
gene_biotype: protein_coding
description:
  LOW QUALITY PROTEIN: desmoglein-4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.


ensembl_gene_id: A0A2U3WU96
symbol: TTR
gene_biotype: protein_coding
description:
  Transthyretin; Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.


ensembl_gene_id: A0A2U3WU99
symbol: DSC2
gene_biotype: protein_coding
description:
  Desmocollin-2; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.


ensembl_gene_id: A0A2U3WUA6
symbol: OXTR
gene_biotype: protein_coding
description:
  Oxytocin receptor; Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.


ensembl_gene_id: A0A2U3WUB9
symbol: SLC24A3
gene_biotype: protein_coding
description:
  Sodium/potassium/calcium exchanger 3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.


ensembl_gene_id: A0A2U3WUH1
symbol: APEX1
gene_biotype: protein_coding
description:
  DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.


ensembl_gene_id: A0A2U3WUJ7
symbol: DSC1
gene_biotype: protein_coding
description:
  Desmocollin-1 isoform X1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.


ensembl_gene_id: A0A2U3WUK1
symbol: DSC3
gene_biotype: protein_coding
description:
  Desmocollin-3; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.


ensembl_gene_id: A0A2U3WUM1
symbol: TP63
gene_biotype: protein_coding
description:
  Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.


ensembl_gene_id: A0A2U3WUP0
symbol: PPP2R2A
gene_biotype: protein_coding
description:
  Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family.


ensembl_gene_id: A0A2U3WUR5
symbol: TMEM55B
gene_biotype: protein_coding
description:
  Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).


ensembl_gene_id: A0A2U3WUS0
symbol: OSGEP
gene_biotype: protein_coding
description:
  Probable tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. OSGEP likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.


ensembl_gene_id: A0A2U3WUT2
symbol: SLC5A9
gene_biotype: protein_coding
description:
  Sodium/glucose cotransporter 4 isoform X1; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.


ensembl_gene_id: A0A2U3WUU0
symbol: CMPK1
gene_biotype: protein_coding
description:
  UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.


ensembl_gene_id: A0A2U3WUZ0
symbol: EXOC2
gene_biotype: protein_coding
description:
  Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family.


ensembl_gene_id: A0A2U3WV08
symbol: ROR1
gene_biotype: protein_coding
description:
  Tyrosine-protein kinase transmembrane receptor ROR1 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.


ensembl_gene_id: A0A2U3WV15
symbol: PIK3CB
gene_biotype: protein_coding
description:
  Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family.


ensembl_gene_id: A0A2U3WV63
symbol: RRP8
gene_biotype: protein_coding
description:
  Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...]


ensembl_gene_id: A0A2U3WV65
symbol: EIF3H
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 3 subunit H; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...]


ensembl_gene_id: A0A2U3WV81
symbol: TAF10
gene_biotype: protein_coding
description:
  Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family.


ensembl_gene_id: A0A2U3WVB4
symbol: LOC101370081
gene_biotype: protein_coding
description:
  S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...]


ensembl_gene_id: A0A2U3WVB6
symbol: SUCLG2
gene_biotype: protein_coding
description:
  Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial; GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.


ensembl_gene_id: A0A2U3WVC6
symbol: CRHBP
gene_biotype: protein_coding
description:
  Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family.


ensembl_gene_id: A0A2U3WVD2
symbol: ALDH7A1
gene_biotype: protein_coding
description:
  Alpha-aminoadipic semialdehyde dehydrogenase isoform X1; Belongs to the aldehyde dehydrogenase family.


ensembl_gene_id: A0A2U3WVF1
symbol: NTF3
gene_biotype: protein_coding
description:
  Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family.


ensembl_gene_id: A0A2U3WVK7
symbol: LOC101366343
gene_biotype: protein_coding
description:
  Uricase; Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin. Belongs to the uricase family.


ensembl_gene_id: A0A2U3WVX8
symbol: DLAT
gene_biotype: protein_coding
description:
  Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).


ensembl_gene_id: A0A2U3WVY5
symbol: IL18
gene_biotype: protein_coding
description:
  Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.


ensembl_gene_id: A0A2U3WVY6
symbol: LOC101381131
gene_biotype: protein_coding
description:
  LOW QUALITY PROTEIN: uncharacterized protein LOC101381131; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.


ensembl_gene_id: A0A2U3WW47
symbol: PHKA1
gene_biotype: protein_coding
description:
  Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I.


ensembl_gene_id: A0A2U3WW99
symbol: RIOK3
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase RIO3; Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses.


ensembl_gene_id: A0A2U3WWA9
symbol: UBA2
gene_biotype: protein_coding
description:
  SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family.


ensembl_gene_id: A0A2U3WWF9
symbol: SPA17
gene_biotype: protein_coding
description:
  Sperm surface protein Sp17; Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates.


ensembl_gene_id: A0A2U3WWH5
symbol: MTR
gene_biotype: protein_coding
description:
  Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.


ensembl_gene_id: A0A2U3WWL4
symbol: NCAPD2
gene_biotype: protein_coding
description:
  Condensin complex subunit 1; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.


ensembl_gene_id: A0A2U3WWM1
symbol: NOP2
gene_biotype: protein_coding
description:
  Probable 28S rRNA (Cytosine(4447)-C(5))-methyltransferase isoform X1; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.


ensembl_gene_id: A0A2U3WWW6
symbol: ST3GAL1
gene_biotype: protein_coding
description:
  CMP-N-acetylneuraminate-beta-galactosamide- alpha-2,3-sialyltransferase 1; Belongs to the glycosyltransferase 29 family.


ensembl_gene_id: A0A2U3WWX4
symbol: HHATL
gene_biotype: protein_coding
description:
  Protein-cysteine N-palmitoyltransferase HHAT-like protein; Belongs to the membrane-bound acyltransferase family.


ensembl_gene_id: A0A2U3WX12
symbol: POLM
gene_biotype: protein_coding
description:
  DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family.


ensembl_gene_id: A0A2U3WX57
symbol: KCNK15
gene_biotype: protein_coding
description:
  Potassium channel subfamily K member 15; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.


ensembl_gene_id: A0A2U3WX81
symbol: VIPR1
gene_biotype: protein_coding
description:
  Vasoactive intestinal polypeptide receptor 1 isoform X1; Belongs to the G-protein coupled receptor 2 family.


ensembl_gene_id: A0A2U3WXF6
symbol: PRDM4
gene_biotype: protein_coding
description:
  PR domain zinc finger protein 4; May function as a transcription factor involved in cell differentiation.


ensembl_gene_id: A0A2U3WXJ2
symbol: GABRQ
gene_biotype: protein_coding
description:
  Gamma-aminobutyric acid receptor subunit theta; Belongs to the ligand-gated ion channel (TC 1.A.9) family.


ensembl_gene_id: A0A2U3WXM7
symbol: GTPBP4
gene_biotype: protein_coding
description:
  Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.


ensembl_gene_id: A0A2U3WXN5
symbol: GUCY1A2
gene_biotype: protein_coding
description:
  Guanylate cyclase soluble subunit alpha-2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.


ensembl_gene_id: A0A2U3WXP9
symbol: LOC101377835
gene_biotype: protein_coding
description:
  Cytochrome b-c1 complex subunit 7; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain; Belongs to the UQCRB/QCR7 family.


ensembl_gene_id: A0A2U3WXQ0
symbol: RTCB
gene_biotype: protein_coding
description:
  RNA-splicing ligase RtcB homolog; Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.


ensembl_gene_id: A0A2U3WXQ6
symbol: KIF13B
gene_biotype: protein_coding
description:
  Kinesin-like protein KIF13B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.


ensembl_gene_id: A0A2U3WXR4
symbol: B3GAT1
gene_biotype: protein_coding
description:
  Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase; Belongs to the glycosyltransferase 43 family.


ensembl_gene_id: A0A2U3WXW2
symbol: KMO
gene_biotype: protein_coding
description:
  Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract.


ensembl_gene_id: A0A2U3WXZ5
symbol: SDR16C5
gene_biotype: protein_coding
description:
  Epidermal retinol dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family.


ensembl_gene_id: A0A2U3WY31
symbol: GABRB3
gene_biotype: protein_coding
description:
  Gamma-aminobutyric acid receptor subunit beta-3; Belongs to the ligand-gated ion channel (TC 1.A.9) family.


ensembl_gene_id: A0A2U3WY76
symbol: TIPIN
gene_biotype: protein_coding
description:
  TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family.


ensembl_gene_id: A0A2U3WY84
symbol: MAP2K1
gene_biotype: protein_coding
description:
  Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily.


ensembl_gene_id: A0A2U3WYC3
symbol: TRPV5
gene_biotype: protein_coding
description:
  Transient receptor potential cation channel subfamily V member 5; Belongs to the transient receptor (TC 1.A.4) family.


ensembl_gene_id: A0A2U3WYC6
symbol: LSM5
gene_biotype: protein_coding
description:
  U6 snRNA-associated Sm-like protein LSm5; Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.


ensembl_gene_id: A0A2U3WYD4
symbol: VIPR2
gene_biotype: protein_coding
description:
  Vasoactive intestinal polypeptide receptor 2 isoform X1; Belongs to the G-protein coupled receptor 2 family.


ensembl_gene_id: A0A2U3WYD5
symbol: TRPV6
gene_biotype: protein_coding
description:
  Transient receptor potential cation channel subfamily V member 6; Belongs to the transient receptor (TC 1.A.4) family.


ensembl_gene_id: A0A2U3WYN2
symbol: FLT1
gene_biotype: protein_coding
description:
  Vascular endothelial growth factor receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.


ensembl_gene_id: A0A2U3WYN4
symbol: FLT3
gene_biotype: protein_coding
description:
  Receptor-type tyrosine-protein kinase FLT3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.


ensembl_gene_id: A0A2U3WYQ3
symbol: MCM7
gene_biotype: protein_coding
description:
  DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]


ensembl_gene_id: A0A2U3WYQ4
symbol: GJC3
gene_biotype: protein_coding
description:
  Gap junction gamma-3 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Belongs to the connexin family.


ensembl_gene_id: A0A2U3WYT9
symbol: PEX12
gene_biotype: protein_coding
description:
  Peroxisome assembly protein 12; Required for protein import into peroxisomes. Belongs to the pex2/pex10/pex12 family.


ensembl_gene_id: A0A2U3WYX2
symbol: QTRTD1
gene_biotype: protein_coding
description:
  Queuine tRNA-ribosyltransferase accessory subunit 2; Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine); Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.


ensembl_gene_id: A0A2U3WZ03
symbol: KITLG
gene_biotype: protein_coding
description:
  Kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family.


ensembl_gene_id: A0A2U3WZ22
symbol: TSHR
gene_biotype: protein_coding
description:
  Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.


ensembl_gene_id: A0A2U3WZ44
symbol: TRMT2A
gene_biotype: protein_coding
description:
  tRNA (Uracil-5-)-methyltransferase homolog A isoform X1; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.


ensembl_gene_id: A0A2U3WZ51
symbol: COMT
gene_biotype: protein_coding
description:
  Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones.


ensembl_gene_id: A0A2U3WZ61
symbol: CLTCL1
gene_biotype: protein_coding
description:
  Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.


ensembl_gene_id: A0A2U3WZ69
symbol: SLC25A1
gene_biotype: protein_coding
description:
  Tricarboxylate transport protein, mitochondrial; Belongs to the mitochondrial carrier (TC 2.A.29) family.


ensembl_gene_id: A0A2U3WZA5
symbol: POLE
gene_biotype: protein_coding
description:
  DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.


ensembl_gene_id: A0A2U3WZD6
symbol: TRPV2
gene_biotype: protein_coding
description:
  Transient receptor potential cation channel subfamily V member 2; Belongs to the transient receptor (TC 1.A.4) family.


ensembl_gene_id: A0A2U3WZH0
symbol: SEPT5
gene_biotype: protein_coding
description:
  Septin-5; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.


ensembl_gene_id: A0A2U3WZH5
symbol: LOC101382393
gene_biotype: protein_coding
description:
  Protein HIRA; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family.


ensembl_gene_id: A0A2U3WZX9
symbol: EMP3
gene_biotype: protein_coding
description:
  Epithelial membrane protein 3; Probably involved in cell proliferation and cell-cell interactions; Belongs to the PMP-22/EMP/MP20 family.


ensembl_gene_id: A0A2U3WZY5
symbol: CSNK2B
gene_biotype: protein_coding
description:
  Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family.


ensembl_gene_id: A0A2U3WZZ7
symbol: LSM2
gene_biotype: protein_coding
description:
  U6 snRNA-associated Sm-like protein LSm2; Binds specifically to the 3'-terminal U-tract of U6 snRNA.


ensembl_gene_id: A0A2U3X050
symbol: TRPC6
gene_biotype: protein_coding
description:
  Short transient receptor potential channel 6 isoform X1; Belongs to the transient receptor (TC 1.A.4) family.


ensembl_gene_id: A0A2U3X0J4
symbol: ZMPSTE24
gene_biotype: protein_coding
description:
  CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family.


ensembl_gene_id: A0A2U3X0K4
symbol: TRIT1
gene_biotype: protein_coding
description:
  tRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37; Belongs to the IPP transferase family.


ensembl_gene_id: A0A2U3X0P9
symbol: MAT2A
gene_biotype: protein_coding
description:
  S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP.


ensembl_gene_id: A0A2U3X0S4
symbol: COPB1
gene_biotype: protein_coding
description:
  Coatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.


ensembl_gene_id: A0A2U3X0S7
symbol: SUCLG1
gene_biotype: protein_coding
description:
  Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits.


ensembl_gene_id: A0A2U3X0T1
symbol: RAN
gene_biotype: protein_coding
description:
  GTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family.


ensembl_gene_id: A0A2U3X0X7
symbol: PIK3C2A
gene_biotype: protein_coding
description:
  Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha; Belongs to the PI3/PI4-kinase family.


ensembl_gene_id: A0A2U3X112
symbol: HPS5
gene_biotype: protein_coding
description:
  Hermansky-Pudlak syndrome 5 protein homolog; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.


ensembl_gene_id: A0A2U3X139
symbol: MRGPRX2
gene_biotype: protein_coding
description:
  LOW QUALITY PROTEIN: mas-related G-protein coupled receptor member X2; Belongs to the G-protein coupled receptor 1 family.


ensembl_gene_id: A0A2U3X142
symbol: DHRS7
gene_biotype: protein_coding
description:
  Dehydrogenase/reductase SDR family member 7; Belongs to the short-chain dehydrogenases/reductases (SDR) family.


ensembl_gene_id: A0A2U3X183
symbol: CACNG4
gene_biotype: protein_coding
description:
  Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.


ensembl_gene_id: A0A2U3X192
symbol: CACNG1
gene_biotype: protein_coding
description:
  Voltage-dependent calcium channel gamma-1 subunit; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics.


ensembl_gene_id: A0A2U3X1F4
symbol: FBLN1
gene_biotype: protein_coding
description:
  Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes.


ensembl_gene_id: A0A2U3X1I4
symbol: LOC101374864
gene_biotype: protein_coding
description:
  Protoheme IX farnesyltransferase, mitochondrial; Converts protoheme IX and farnesyl diphosphate to heme O. Belongs to the ubiA prenyltransferase family.


ensembl_gene_id: A0A2U3X1J7
symbol: SLC2A9
gene_biotype: protein_coding
description:
  Solute carrier family 2, facilitated glucose transporter member 9 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.


ensembl_gene_id: A0A2U3X1Q6
symbol: PHGDH
gene_biotype: protein_coding
description:
  D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.


ensembl_gene_id: A0A2U3X227
symbol: TAX1BP3
gene_biotype: protein_coding
description:
  Tax1-binding protein 3; May regulate a number of protein-protein interactions by competing for PDZ domain binding sites.


ensembl_gene_id: A0A2U3X233
symbol: LOC101384402
gene_biotype: protein_coding
description:
  1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial isoform X1; Belongs to the cytochrome P450 family.


ensembl_gene_id: A0A2U3X238
symbol: MB
gene_biotype: protein_coding
description:
  Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.


ensembl_gene_id: A0A2U3X248
symbol: NCAPD3
gene_biotype: protein_coding
description:
  Condensin-2 complex subunit D3; Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis.


ensembl_gene_id: A0A2U3X250
symbol: GFM2
gene_biotype: protein_coding
description:
  Ribosome-releasing factor 2, mitochondrial; Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.


ensembl_gene_id: A0A2U3X270
symbol: PPAT
gene_biotype: protein_coding
description:
  Amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.


ensembl_gene_id: A0A2U3X296
symbol: UNG
gene_biotype: protein_coding
description:
  Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.


ensembl_gene_id: A0A2U3X2A0
symbol: TRPV4
gene_biotype: protein_coding
description:
  Transient receptor potential cation channel subfamily V member 4 isoform X1; Belongs to the transient receptor (TC 1.A.4) family.


ensembl_gene_id: A0A2U3X2A2
symbol: SRP72
gene_biotype: protein_coding
description:
  Signal recognition particle subunit SRP72; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane; Belongs to the SRP72 family.


ensembl_gene_id: A0A2U3X2B1
symbol: ISCU
gene_biotype: protein_coding
description:
  Iron-sulfur cluster assembly enzyme ISCU, mitochondrial; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.


ensembl_gene_id: A0A2U3X2B4
symbol: MYO1H
gene_biotype: protein_coding
description:
  Unconventional myosin-Ih; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.


ensembl_gene_id: A0A2U3X2E5
symbol: KIF16B
gene_biotype: protein_coding
description:
  Kinesin-like protein KIF16B isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.


ensembl_gene_id: A0A2U3X2G4
symbol: PGS1
gene_biotype: protein_coding
description:
  CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin; Belongs to the CDP-alcohol phosphatidyltransferase class-II family.


ensembl_gene_id: A0A2U3X2J8
symbol: MVK
gene_biotype: protein_coding
description:
  Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.


ensembl_gene_id: A0A2U3X2L7
symbol: DHX29
gene_biotype: protein_coding
description:
  ATP-dependent RNA helicase DHX29; ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity; Belongs to the DEAD box helicase family. DEAH subfamily.


ensembl_gene_id: A0A2U3X2L9
symbol: IL7
gene_biotype: protein_coding
description:
  Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family.


ensembl_gene_id: A0A2U3X2M5
symbol: RBP2
gene_biotype: protein_coding
description:
  Retinol-binding protein 2; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.


ensembl_gene_id: A0A2U3X2N4
symbol: MED6
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 6; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.


ensembl_gene_id: A0A2U3X2U3
symbol: HTR3A
gene_biotype: protein_coding
description:
  5-hydroxytryptamine receptor 3A isoform X1; Belongs to the ligand-gated ion channel (TC 1.A.9) family.


ensembl_gene_id: A0A2U3X2V0
symbol: RBP1
gene_biotype: protein_coding
description:
  Retinol-binding protein 1; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.


ensembl_gene_id: A0A2U3X2V9
symbol: IFNG
gene_biotype: protein_coding
description:
  Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.


ensembl_gene_id: A0A2U3X2X8
symbol: PHYKPL
gene_biotype: protein_coding
description:
  5-phosphohydroxy-L-lysine phospho-lyase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.


ensembl_gene_id: A0A2U3X2Y7
symbol: AVPR1A
gene_biotype: protein_coding
description:
  Vasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.


ensembl_gene_id: A0A2U3X303
symbol: OXSM
gene_biotype: protein_coding
description:
  3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial; May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function. Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.


ensembl_gene_id: A0A2U3X310
symbol: NSUN2
gene_biotype: protein_coding
description:
  tRNA (Cytosine(34)-C(5))-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.


ensembl_gene_id: A0A2U3X327
symbol: HMGCS1
gene_biotype: protein_coding
description:
  3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.


ensembl_gene_id: A0A2U3X331
symbol: TGFBR2
gene_biotype: protein_coding
description:
  TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]


ensembl_gene_id: A0A2U3X387
symbol: MED10
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 10; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.


ensembl_gene_id: A0A2U3X393
symbol: SLC5A7
gene_biotype: protein_coding
description:
  High affinity choline transporter 1; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.


ensembl_gene_id: A0A2U3X3K6
symbol: SLC25A26
gene_biotype: protein_coding
description:
  S-adenosylmethionine mitochondrial carrier protein isoform X1; Belongs to the mitochondrial carrier (TC 2.A.29) family.


ensembl_gene_id: A0A2U3X3L2
symbol: LOC101369405
gene_biotype: protein_coding
description:
  Glyoxylate reductase/hydroxypyruvate reductase-like; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.


ensembl_gene_id: A0A2U3X3L7
symbol: CTDP1
gene_biotype: protein_coding
description:
  RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.


ensembl_gene_id: A0A2U3X3R4
symbol: NDOR1
gene_biotype: protein_coding
description:
  NADPH-dependent diflavin oxidoreductase 1; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe/S cluster of CIAPIN1. In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.


ensembl_gene_id: A0A2U3X405
symbol: SEPT7
gene_biotype: protein_coding
description:
  Septin-7 isoform X1; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.


ensembl_gene_id: A0A2U3X412
symbol: VBP1
gene_biotype: protein_coding
description:
  Prefoldin subunit 3; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins; Belongs to the prefoldin subunit alpha family.


ensembl_gene_id: A0A2U3X428
symbol: LOC101380875
gene_biotype: protein_coding
description:
  Small nuclear ribonucleoprotein E; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development.


ensembl_gene_id: A0A2U3X473
symbol: LOC101377859
gene_biotype: protein_coding
description:
  Acid-sensing ion channel 2-like; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.


ensembl_gene_id: A0A2U3X486
symbol: ULK1
gene_biotype: protein_coding
description:
  Serine/threonine-protein kinase; Serine/threonine-protein kinase involved in autophagy in response to starvation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.


ensembl_gene_id: A0A2U3X4B6
symbol: LOC101381163
gene_biotype: protein_coding
description:
  Cytochrome b-c1 complex subunit Rieske, mitochondrial; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.


ensembl_gene_id: A0A2U3X4B8
symbol: LOC101379124
gene_biotype: protein_coding
description:
  Putative EGF-like module-containing mucin-like hormone receptor-like 4; Belongs to the G-protein coupled receptor 2 family.


ensembl_gene_id: A0A2U3X4H5
symbol: SRY
gene_biotype: protein_coding
description:
  Sex-determining region Y protein; Transcriptional regulator that controls a genetic switch in male development; Belongs to the SRY family.


ensembl_gene_id: A0A2U3X4H9
symbol: XRN2
gene_biotype: protein_coding
description:
  5'-3' exoribonuclease; Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.


ensembl_gene_id: A0A2U3X4J3
symbol: RP2
gene_biotype: protein_coding
description:
  Protein XRP2; Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization.


ensembl_gene_id: A0A2U3X4P3
symbol: ADGRE1
gene_biotype: protein_coding
description:
  EGF-like module-containing mucin-like hormone receptor-like 1; Belongs to the G-protein coupled receptor 2 family.


ensembl_gene_id: A0A2U3X4P9
symbol: GABRG1
gene_biotype: protein_coding
description:
  Gamma-aminobutyric acid receptor subunit gamma-1; Belongs to the ligand-gated ion channel (TC 1.A.9) family.


ensembl_gene_id: A0A2U3X4X0
symbol: PMP22
gene_biotype: protein_coding
description:
  Peripheral myelin protein 22; Might be involved in growth regulation, and in myelinization in the peripheral nervous system; Belongs to the PMP-22/EMP/MP20 family.


ensembl_gene_id: A0A2U3X4X2
symbol: BLVRA
gene_biotype: protein_coding
description:
  Biliverdin reductase A; Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor; Belongs to the Gfo/Idh/MocA family. Biliverdin reductase subfamily.


ensembl_gene_id: A0A2U3X4Y4
symbol: EIF3D
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 3 subunit D; mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl- tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required  [...]


ensembl_gene_id: A0A2U3X4Y7
symbol: CACNG2
gene_biotype: protein_coding
description:
  Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.


ensembl_gene_id: A0A2U3X535
symbol: ATG7
gene_biotype: protein_coding
description:
  Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]


ensembl_gene_id: A0A2U3X538
symbol: TAMM41
gene_biotype: protein_coding
description:
  Phosphatidate cytidylyltransferase, mitochondrial; Catalyzes the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA) in the mitochondrial inner membrane. Required for the biosynthesis of the dimeric phospholipid cardiolipin, which stabilizes supercomplexes of the mitochondrial respiratory chain in the mitochondrial inner membrane.


ensembl_gene_id: A0A2U3X551
symbol: DUSP22
gene_biotype: protein_coding
description:
  Dual specificity protein phosphatase 22; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.


ensembl_gene_id: A0A2U3X555
symbol: KCNK18
gene_biotype: protein_coding
description:
  LOW QUALITY PROTEIN: potassium channel subfamily K member 18; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.


ensembl_gene_id: A0A2U3X567
symbol: NDUFA10
gene_biotype: protein_coding
description:
  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.


ensembl_gene_id: A0A2U3X569
symbol: GABRE
gene_biotype: protein_coding
description:
  Gamma-aminobutyric acid receptor subunit epsilon; Belongs to the ligand-gated ion channel (TC 1.A.9) family.


ensembl_gene_id: A0A2U3X596
symbol: CNR1
gene_biotype: protein_coding
description:
  Cannabinoid receptor 1; G-protein coupled receptor for cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2- arachidonoylglycerol (2-AG). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP. In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while d [...]


ensembl_gene_id: A0A2U3X5G3
symbol: BAMBI
gene_biotype: protein_coding
description:
  BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.


ensembl_gene_id: A0A2U3X5H2
symbol: POP4
gene_biotype: protein_coding
description:
  Ribonuclease P protein subunit p29; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.


ensembl_gene_id: A0A2U3X5J5
symbol: LOC101370206
gene_biotype: protein_coding
description:
  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like; Belongs to the MHC class II family.


ensembl_gene_id: A0A2U3X5Q6
symbol: LOC101377954
gene_biotype: protein_coding
description:
  Septin-14-like; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.


ensembl_gene_id: A0A2U3X5R2
symbol: SEPT14
gene_biotype: protein_coding
description:
  LOW QUALITY PROTEIN: septin-14; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.


ensembl_gene_id: A0A2U3X5T9
symbol: SSTR4
gene_biotype: protein_coding
description:
  LOW QUALITY PROTEIN: somatostatin receptor type 4; Belongs to the G-protein coupled receptor 1 family.


ensembl_gene_id: A0A2U3X5V4
symbol: GPR35
gene_biotype: protein_coding
description:
  LOW QUALITY PROTEIN: G-protein coupled receptor 35; Belongs to the G-protein coupled receptor 1 family.


ensembl_gene_id: A0A2U3X5W8
symbol: LOC101373442
gene_biotype: protein_coding
description:
  LOW QUALITY PROTEIN: trace amine-associated receptor 6; Belongs to the G-protein coupled receptor 1 family.


ensembl_gene_id: A0A2U3X5X4
symbol: LOC101373155
gene_biotype: protein_coding
description:
  LOW QUALITY PROTEIN: trace amine-associated receptor 8; Belongs to the G-protein coupled receptor 1 family.


ensembl_gene_id: A0A2U3X5Z3
symbol: TAAR9
gene_biotype: protein_coding
description:
  LOW QUALITY PROTEIN: trace amine-associated receptor 9; Belongs to the G-protein coupled receptor 1 family.


ensembl_gene_id: A0A2U3X610
symbol: LOC101386077
gene_biotype: protein_coding
description:
  Prefoldin subunit 4; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins; Belongs to the prefoldin subunit beta family.


ensembl_gene_id: A0A2U3X617
symbol: PIGP
gene_biotype: protein_coding
description:
  Phosphatidylinositol N-acetylglucosaminyltransferase subunit P; Part of the complex catalyzing the transfer of N- acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.


ensembl_gene_id: A0A2U3X620
symbol: ARPC5L
gene_biotype: protein_coding
description:
  Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.


ensembl_gene_id: A0A2U3X661
symbol: RPL36A
gene_biotype: protein_coding
description:
  LOW QUALITY PROTEIN: 60S ribosomal protein L36a; Belongs to the eukaryotic ribosomal protein eL42 family.


ensembl_gene_id: A0A2U3X666
symbol: FPR2
gene_biotype: protein_coding
description:
  LOW QUALITY PROTEIN: N-formyl peptide receptor 2; Belongs to the G-protein coupled receptor 1 family.


ensembl_gene_id: A0A2U3X689
symbol: TAAR5
gene_biotype: protein_coding
description:
  LOW QUALITY PROTEIN: trace amine-associated receptor 5; Belongs to the G-protein coupled receptor 1 family.


ensembl_gene_id: A0A2U3X6B1
symbol: TRMT5
gene_biotype: protein_coding
description:
  tRNA (guanine(37)-N1)-methyltransferase; Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding; Belongs to the TRM5 / TYW2 family.


ensembl_gene_id: A0A2U3X6D0
symbol: HADHB
gene_biotype: protein_coding
description:
  LOW QUALITY PROTEIN: trifunctional enzyme subunit beta, mitochondrial; Belongs to the thiolase-like superfamily. Thiolase family.


ensembl_gene_id: A0A2U3Z9M2
symbol: EXOC7
gene_biotype: protein_coding
description:
  Exocyst complex component 7; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.


ensembl_gene_id: A0A2U3Z9V3
symbol: LOC101374365
gene_biotype: protein_coding
description:
  Histone-arginine methyltransferase CARM1-like; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.


ensembl_gene_id: A0A2U3ZA01
symbol: LOC101376004
gene_biotype: protein_coding
description:
  LOW QUALITY PROTEIN: olfactory receptor 10R2-like; Belongs to the G-protein coupled receptor 1 family.


ensembl_gene_id: A0A2U3ZA66
symbol: MYO7A
gene_biotype: protein_coding
description:
  Unconventional myosin-VIIa isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.


ensembl_gene_id: A0A2U3ZA82
symbol: MED18
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 18; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.


ensembl_gene_id: A0A2U3ZA91
symbol: RBKS
gene_biotype: protein_coding
description:
  Ribokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.


ensembl_gene_id: A0A2U3ZA99
symbol: PPME1
gene_biotype: protein_coding
description:
  Protein phosphatase methylesterase 1; Demethylates proteins that have been reversibly carboxymethylated.


ensembl_gene_id: A0A2U3ZAA1
symbol: EIF2B4
gene_biotype: protein_coding
description:
  Translation initiation factor eIF-2B subunit delta isoform X1; Belongs to the eIF-2B alpha/beta/delta subunits family.


ensembl_gene_id: A0A2U3ZAI8
symbol: GUCY1B3
gene_biotype: protein_coding
description:
  Guanylate cyclase soluble subunit beta-1 isoform X1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.


ensembl_gene_id: A0A2U3ZAM4
symbol: SEPT9
gene_biotype: protein_coding
description:
  Septin-9 isoform X1; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.


ensembl_gene_id: A0A2U3ZAR7
symbol: TICAM1
gene_biotype: protein_coding
description:
  TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines.


ensembl_gene_id: A0A2U3ZB48
symbol: HMCES
gene_biotype: protein_coding
description:
  Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...]


ensembl_gene_id: A0A2U3ZB63
symbol: NUP93
gene_biotype: protein_coding
description:
  Nuclear pore complex protein Nup93; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance; Belongs to the nucleoporin interacting component (NIC) family.


ensembl_gene_id: A0A2U3ZB72
symbol: COQ9
gene_biotype: protein_coding
description:
  Ubiquinone biosynthesis protein; Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.


ensembl_gene_id: A0A2U3ZB78
symbol: ADGRG5
gene_biotype: protein_coding
description:
  LOW QUALITY PROTEIN: probable G-protein coupled receptor 114; Belongs to the G-protein coupled receptor 2 family.


ensembl_gene_id: A0A2U3ZBA2
symbol: NUDT21
gene_biotype: protein_coding
description:
  Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The  [...]


ensembl_gene_id: A0A2U3ZBG7
symbol: ARL4C
gene_biotype: protein_coding
description:
  ADP-ribosylation factor-like protein 4C isoform X1; Belongs to the small GTPase superfamily. Arf family.


ensembl_gene_id: A0A2U3ZBH9
symbol: OPA1
gene_biotype: protein_coding
description:
  Dynamin-like 120 kDa protein, mitochondrial isoform X1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.


ensembl_gene_id: A0A2U3ZBQ1
symbol: PDGFRA
gene_biotype: protein_coding
description:
  Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.


ensembl_gene_id: A0A2U3ZBU4
symbol: LONP1
gene_biotype: protein_coding
description:
  Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand- specific manner. May regulate mi [...]


ensembl_gene_id: A0A2U3ZCA1
symbol: LOC101364183
gene_biotype: protein_coding
description:
  LOW QUALITY PROTEIN: major histocompatibility complex class I-related gene protein; Belongs to the MHC class I family.


ensembl_gene_id: A0A2U3ZCC0
symbol: KCND1
gene_biotype: protein_coding
description:
  Potassium voltage-gated channel subfamily D member 1 isoform X1; Belongs to the potassium channel family.


ensembl_gene_id: A0A2U3ZCC6
symbol: CACNA1E
gene_biotype: protein_coding
description:
  Voltage-dependent R-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents.


ensembl_gene_id: A0A2U3ZCI0
symbol: CAPZB
gene_biotype: protein_coding
description:
  F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.


ensembl_gene_id: A0A2U3ZCI6
symbol: MINOS1
gene_biotype: protein_coding
description:
  MICOS complex subunit MIC10; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.


ensembl_gene_id: A0A2U3ZCP5
symbol: KIT
gene_biotype: protein_coding
description:
  Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.


ensembl_gene_id: A0A2U3ZCV1
symbol: LOC101381443
gene_biotype: protein_coding
description:
  Uncharacterized protein LOC101381443 isoform X1; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.


ensembl_gene_id: A0A2U3ZCY3
symbol: GDA
gene_biotype: protein_coding
description:
  Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.


ensembl_gene_id: A0A2U3ZCZ4
symbol: GPHN
gene_biotype: protein_coding
description:
  Molybdopterin molybdenumtransferase; Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.


ensembl_gene_id: A0A2U3ZD10
symbol: SPDL1
gene_biotype: protein_coding
description:
  Protein Spindly; Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment.


ensembl_gene_id: A0A2U3ZDB6
symbol: LOC101378393
gene_biotype: protein_coding
description:
  LOW QUALITY PROTEIN: thyrotropin-releasing hormone receptor-like; Belongs to the G-protein coupled receptor 1 family.


ensembl_gene_id: A0A2U3ZDC8
symbol: CTU2
gene_biotype: protein_coding
description:
  Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with CTU1/ATPBD3 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Belongs to the CTU2/NCS2 family.


ensembl_gene_id: A0A2U3ZDJ8
symbol: MRTO4
gene_biotype: protein_coding
description:
  Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.


ensembl_gene_id: A0A2U3ZDR9
symbol: LIMS1
gene_biotype: protein_coding
description:
  LIM and senescent cell antigen-like-containing domain protein; Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors.


ensembl_gene_id: A0A2U3ZDU0
symbol: RPL3
gene_biotype: protein_coding
description:
  LOW QUALITY PROTEIN: 60S ribosomal protein L3; Belongs to the universal ribosomal protein uL3 family.


ensembl_gene_id: A0A2U3ZDV2
symbol: KIF1C
gene_biotype: protein_coding
description:
  Kinesin-like protein KIF1C isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.


ensembl_gene_id: A0A2U3ZDW5
symbol: MAT2B
gene_biotype: protein_coding
description:
  Methionine adenosyltransferase 2 subunit beta; Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine.


ensembl_gene_id: A0A2U3ZE29
symbol: LOC101375744
gene_biotype: protein_coding
description:
  LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like; Belongs to the heat shock protein 70 family.


ensembl_gene_id: A0A2U3ZE92
symbol: ELOF1
gene_biotype: protein_coding
description:
  Transcription elongation factor 1 homolog; Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions. Belongs to the ELOF1 family.


ensembl_gene_id: A0A2U3ZEG4
symbol: LARS2
gene_biotype: protein_coding
description:
  Probable leucine--tRNA ligase, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family.


ensembl_gene_id: A0A2U3ZEH1
symbol: SOAT1
gene_biotype: protein_coding
description:
  LOW QUALITY PROTEIN: sterol O-acyltransferase 1; Belongs to the membrane-bound acyltransferase family.


ensembl_gene_id: A0A2U3ZEM6
symbol: KIF7
gene_biotype: protein_coding
description:
  Kinesin-like protein KIF7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.


ensembl_gene_id: A0A2U3ZEN5
symbol: COQ6
gene_biotype: protein_coding
description:
  Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.


ensembl_gene_id: A0A2U3ZES2
symbol: ACP6
gene_biotype: protein_coding
description:
  Lysophosphatidic acid phosphatase type 6 isoform X1; Belongs to the histidine acid phosphatase family.


ensembl_gene_id: A0A2U3ZET4
symbol: LOC101365290
gene_biotype: protein_coding
description:
  Guanylate cyclase soluble subunit beta-2-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.


ensembl_gene_id: A0A2U3ZF48
symbol: DNM2
gene_biotype: protein_coding
description:
  Dynamin-2 isoform X1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.


ensembl_gene_id: A0A2U3ZF57
symbol: NCAPH
gene_biotype: protein_coding
description:
  Condensin complex subunit 2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.


ensembl_gene_id: A0A2U3ZF60
symbol: SLC8A1
gene_biotype: protein_coding
description:
  Sodium/calcium exchanger 1 isoform X1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.


ensembl_gene_id: A0A2U3ZFP8
symbol: ORC1
gene_biotype: protein_coding
description:
  Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.


ensembl_gene_id: A0A2U3ZFR4
symbol: STARD9
gene_biotype: protein_coding
description:
  stAR-related lipid transfer protein 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.


ensembl_gene_id: A0A2U3ZFT8
symbol: LOC101363218
gene_biotype: protein_coding
description:
  LOW QUALITY PROTEIN: sodium/glucose cotransporter 1-like; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.


ensembl_gene_id: A0A2U3ZFV2
symbol: SNRPD3
gene_biotype: protein_coding
description:
  Small nuclear ribonucleoprotein Sm D3; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing.


ensembl_gene_id: A0A2U3ZFX8
symbol: ELOVL1
gene_biotype: protein_coding
description:
  Elongation of very long chain fatty acids protein 1; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that  [...]


ensembl_gene_id: A0A2U3ZFZ9
symbol: HYI
gene_biotype: protein_coding
description:
  Putative hydroxypyruvate isomerase; Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde); Belongs to the hyi family.


ensembl_gene_id: A0A2U3ZG08
symbol: BOP1
gene_biotype: protein_coding
description:
  Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.


ensembl_gene_id: A0A2U3ZG17
symbol: NAPRT
gene_biotype: protein_coding
description:
  Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family.


ensembl_gene_id: A0A2U3ZG19
symbol: MAF1
gene_biotype: protein_coding
description:
  Repressor of RNA polymerase III transcription MAF1; Element of the TORC1 signaling pathway that acts as a mediator of diverse signals and that represses RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA. Belongs to the MAF1 family.


ensembl_gene_id: A0A2U3ZGC4
symbol: DNAJC10
gene_biotype: protein_coding
description:
  DnaJ homolog subfamily C member 10; Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins.


ensembl_gene_id: A0A2U3ZGF6
symbol: PISD
gene_biotype: protein_coding
description:
  Phosphatidylserine decarboxylase proenzyme, mitochondrial; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.


ensembl_gene_id: A0A2U3ZGG9
symbol: ACAT2
gene_biotype: protein_coding
description:
  acetyl-CoA acetyltransferase, cytosolic isoform X1; Belongs to the thiolase-like superfamily. Thiolase family.


ensembl_gene_id: A0A2U3ZGP5
symbol: LOC101375937
gene_biotype: protein_coding
description:
  Adenosine receptor A3; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.


ensembl_gene_id: A0A2U3ZGT5
symbol: KIF28P
gene_biotype: protein_coding
description:
  LOW QUALITY PROTEIN: kinesin-like protein KIF28P; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.


ensembl_gene_id: A0A2U3ZGU6
symbol: EIF1AX
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 1A, X-chromosomal isoform X1; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.


ensembl_gene_id: A0A2U3ZGZ3
symbol: DPH2
gene_biotype: protein_coding
description:
  2-(3-amino-3-carboxypropyl)histidine synthase subunit 2; Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2.


ensembl_gene_id: A0A2U3ZH32
symbol: HSD17B13
gene_biotype: protein_coding
description:
  17-beta-hydroxysteroid dehydrogenase 13 isoform X1; Belongs to the short-chain dehydrogenases/reductases (SDR) family.


ensembl_gene_id: A0A2U3ZH46
symbol: METTL1
gene_biotype: protein_coding
description:
  tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.


ensembl_gene_id: A0A2U3ZH77
symbol: SLC25A25
gene_biotype: protein_coding
description:
  Calcium-binding mitochondrial carrier protein SCaMC-2 isoform X1; Belongs to the mitochondrial carrier (TC 2.A.29) family.


ensembl_gene_id: A0A2U3ZHA1
symbol: NDUFB8
gene_biotype: protein_coding
description:
  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.


ensembl_gene_id: A0A2U3ZHE6
symbol: OBFC1
gene_biotype: protein_coding
description:
  CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication.


ensembl_gene_id: A0A2U3ZHH0
symbol: PLG
gene_biotype: protein_coding
description:
  Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...]


ensembl_gene_id: A0A2U3ZHK2
symbol: DAD1
gene_biotype: protein_coding
description:
  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the [...]


ensembl_gene_id: A0A2U3ZHP9
symbol: KIF21A
gene_biotype: protein_coding
description:
  Kinesin-like protein KIF21A isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.


ensembl_gene_id: A0A2U3ZHW5
symbol: LOC101376049
gene_biotype: protein_coding
description:
  LOW QUALITY PROTEIN: nucleosome assembly protein 1-like 1; Belongs to the nucleosome assembly protein (NAP) family.


ensembl_gene_id: A0A2U3ZHY3
symbol: FABP2
gene_biotype: protein_coding
description:
  Fatty acid-binding protein, intestinal; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.


ensembl_gene_id: A0A2U3ZHY9
symbol: SLC44A3
gene_biotype: protein_coding
description:
  Choline transporter-like protein 3 isoform X1; Belongs to the CTL (choline transporter-like) family.


ensembl_gene_id: A0A2U3ZI91
symbol: ANAPC4
gene_biotype: protein_coding
description:
  Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family.


ensembl_gene_id: A0A2U3ZIC7
symbol: SUFU
gene_biotype: protein_coding
description:
  Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of  [...]


ensembl_gene_id: A0A2U3ZIE4
symbol: FLAD1
gene_biotype: protein_coding
description:
  FAD synthase; Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme. In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily.


ensembl_gene_id: A0A2U3ZIH2
symbol: TSR3
gene_biotype: protein_coding
description:
  Probable ribosome biogenesis protein C16orf42 homolog; Probable pre-rRNA processing protein involved in ribosome biogenesis.


ensembl_gene_id: A0A2U3ZIS8
symbol: KCNS2
gene_biotype: protein_coding
description:
  Potassium voltage-gated channel subfamily S member 2 isoform X1; Belongs to the potassium channel family.


ensembl_gene_id: A0A2U3ZIU5
symbol: INSIG1
gene_biotype: protein_coding
description:
  Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.


ensembl_gene_id: A0A2U3ZIX1
symbol: LOC101371798
gene_biotype: protein_coding
description:
  methylglutaconyl-CoA hydratase, mitochondrial-like isoform X1; Belongs to the enoyl-CoA hydratase/isomerase family.


ensembl_gene_id: A0A2U3ZJ09
symbol: LOC101386882
gene_biotype: protein_coding
description:
  LOW QUALITY PROTEIN: cytochrome c, testis-specific-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.


ensembl_gene_id: A0A2U3ZJ86
symbol: NADK2
gene_biotype: protein_coding
description:
  NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.


ensembl_gene_id: A0A2U3ZJB1
symbol: EIF3A
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 3 subunit A; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre- initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termi [...]


ensembl_gene_id: A0A2U3ZJE1
symbol: KATNA1
gene_biotype: protein_coding
description:
  Katanin p60 ATPase-containing subunit A1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal p [...]


ensembl_gene_id: A0A2U3ZJE7
symbol: ESR1
gene_biotype: protein_coding
description:
  Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.


ensembl_gene_id: A0A2U3ZJG8
symbol: GOSR1
gene_biotype: protein_coding
description:
  Golgi SNAP receptor complex member 1; Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor.


ensembl_gene_id: A0A2U3ZJH2
symbol: RPA1
gene_biotype: protein_coding
description:
  Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.


ensembl_gene_id: A0A2U3ZJI3
symbol: POLR3F
gene_biotype: protein_coding
description:
  DNA-directed RNA polymerase III subunit RPC6; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs; Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.


ensembl_gene_id: A0A2U3ZJM8
symbol: SIRT5
gene_biotype: protein_coding
description:
  NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinyl [...]


ensembl_gene_id: A0A2U3ZJM9
symbol: LOC101368838
gene_biotype: protein_coding
description:
  Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.


ensembl_gene_id: A0A2U3ZJN9
symbol: MDN1
gene_biotype: protein_coding
description:
  Midasin; Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits; Belongs to the midasin family.


ensembl_gene_id: A0A2U3ZJR5
symbol: LOC105757628
gene_biotype: protein_coding
description:
  LOW QUALITY PROTEIN: taste receptor type 2 member 16; Belongs to the G-protein coupled receptor T2R family.


ensembl_gene_id: A0A2U3ZK06
symbol: GABRA5
gene_biotype: protein_coding
description:
  Gamma-aminobutyric acid receptor subunit alpha-5 isoform X1; Belongs to the ligand-gated ion channel (TC 1.A.9) family.


ensembl_gene_id: A0A2U3ZK54
symbol: MDM4
gene_biotype: protein_coding
description:
  Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family.


ensembl_gene_id: A0A2U3ZK64
symbol: SLC25A22
gene_biotype: protein_coding
description:
  LOW QUALITY PROTEIN: mitochondrial glutamate carrier 1; Belongs to the mitochondrial carrier (TC 2.A.29) family.


ensembl_gene_id: A0A2U3ZK74
symbol: EIF3E
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...]


ensembl_gene_id: A0A2U3ZKJ3
symbol: CLUH
gene_biotype: protein_coding
description:
  Clustered mitochondria protein homolog; mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria. Specifically binds mRNAs of nuclear- encoded mitochondrial proteins in the cytoplasm and regulates transport or translation of these transcripts close to mitochondria, playing a role in mitochondrial biogenesis; Belongs to the CLU family.


ensembl_gene_id: A0A2U3ZKT5
symbol: CAMK1
gene_biotype: protein_coding
description:
  Calcium/calmodulin-dependent protein kinase type 1 isoform X2; Belongs to the protein kinase superfamily.


ensembl_gene_id: A0A2U3ZKT6
symbol: KIF14
gene_biotype: protein_coding
description:
  Kinesin-like protein KIF14 isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.


ensembl_gene_id: A0A2U3ZKX6
symbol: AGO2
gene_biotype: protein_coding
description:
  Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]


ensembl_gene_id: A0A2U3ZKX7
symbol: LOC101365815
gene_biotype: protein_coding
description:
  LOW QUALITY PROTEIN: solute carrier family 2, facilitated glucose transporter member 3-like; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.


ensembl_gene_id: A0A2U3ZKZ1
symbol: LOC101368548
gene_biotype: protein_coding
description:
  Calcium-binding mitochondrial carrier protein SCaMC-1-like; Belongs to the mitochondrial carrier (TC 2.A.29) family.


ensembl_gene_id: A0A2U3ZL73
symbol: NAP1L1
gene_biotype: protein_coding
description:
  Nucleosome assembly protein 1-like 1 isoform X1; Belongs to the nucleosome assembly protein (NAP) family.


ensembl_gene_id: A0A2U3ZLH6
symbol: U2AF2
gene_biotype: protein_coding
description:
  U2 snRNP auxiliary factor large subunit; Necessary for the splicing of pre-mRNA. Belongs to the splicing factor SR family.


ensembl_gene_id: A0A2U3ZLJ6
symbol: SLC5A10
gene_biotype: protein_coding
description:
  Sodium/glucose cotransporter 5 isoform X1; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.


ensembl_gene_id: A0A2U3ZLJ8
symbol: LOC101381676
gene_biotype: protein_coding
description:
  LOW QUALITY PROTEIN: keratin, type II cytoskeletal 3-like; Belongs to the intermediate filament family.


ensembl_gene_id: A0A2U3ZLL6
symbol: SEPT6
gene_biotype: protein_coding
description:
  Septin-6 isoform X1; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.


ensembl_gene_id: A0A2U3ZLP9
symbol: SLC2A10
gene_biotype: protein_coding
description:
  Solute carrier family 2, facilitated glucose transporter member 10; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.


ensembl_gene_id: A0A2U3ZLR9
symbol: LOC101367179
gene_biotype: protein_coding
description:
  LOW QUALITY PROTEIN: antizyme inhibitor 2-like; Belongs to the Orn/Lys/Arg decarboxylase class-II family.


ensembl_gene_id: A0A2U3ZLW7
symbol: LOC101365820
gene_biotype: protein_coding
description:
  Histone H3.1 isoform X1; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.


ensembl_gene_id: A0A2U3ZM40
symbol: LOC101364414
gene_biotype: protein_coding
description:
  LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 3C-like; Belongs to the ligand-gated ion channel (TC 1.A.9) family.


ensembl_gene_id: A0A2U3ZM60
symbol: CHRD
gene_biotype: protein_coding
description:
  Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes.


ensembl_gene_id: A0A2U3ZM64
symbol: MAP3K13
gene_biotype: protein_coding
description:
  Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7.


ensembl_gene_id: A0A2U3ZMJ3
symbol: KIF13A
gene_biotype: protein_coding
description:
  Kinesin-like protein KIF13A isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.


ensembl_gene_id: A0A2U3ZML9
symbol: KCNC4
gene_biotype: protein_coding
description:
  Potassium voltage-gated channel subfamily C member 4 isoform X1; Belongs to the potassium channel family.


ensembl_gene_id: A0A2U3ZMN5
symbol: ATP5G2
gene_biotype: protein_coding
description:
  ATP synthase F(0) complex subunit C2, mitochondrial isoform X1; Belongs to the ATPase C chain family.


ensembl_gene_id: A0A2U3ZMQ7
symbol: LOC101377452
gene_biotype: protein_coding
description:
  LOW QUALITY PROTEIN: putative testis-specific Y-encoded-like protein 3; Belongs to the nucleosome assembly protein (NAP) family.


ensembl_gene_id: A0A2U3ZMS1
symbol: KCNS3
gene_biotype: protein_coding
description:
  Potassium voltage-gated channel subfamily S member 3 isoform X1; Belongs to the potassium channel family.


ensembl_gene_id: A0A2U3ZMS2
symbol: LOC101379472
gene_biotype: protein_coding
description:
  LOW QUALITY PROTEIN: uncharacterized protein C20orf173 homolog; Belongs to the glycosyltransferase 29 family.


ensembl_gene_id: A0A2U3ZMT4
symbol: TP73
gene_biotype: protein_coding
description:
  Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.


ensembl_gene_id: A0A2U3ZMY1
symbol: EIF6
gene_biotype: protein_coding
description:
  Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)- dependent protein kinase C activity. In tissues responsive to insulin, contro [...]


ensembl_gene_id: A0A2U3ZMZ2
symbol: LOC101373661
gene_biotype: protein_coding
description:
  LOW QUALITY PROTEIN: olfactory receptor 51F2-like; Belongs to the G-protein coupled receptor 1 family.


ensembl_gene_id: A0A2U3ZMZ3
symbol: LOC101380614
gene_biotype: protein_coding
description:
  LOW QUALITY PROTEIN: olfactory receptor 51G2-like; Belongs to the G-protein coupled receptor 1 family.


ensembl_gene_id: A0A2U3ZN83
symbol: TEAD3
gene_biotype: protein_coding
description:
  Transcriptional enhancer factor TEF-5; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis.


ensembl_gene_id: A0A2U3ZND5
symbol: LOC101372009
gene_biotype: protein_coding
description:
  Solute carrier family 2, facilitated glucose transporter member 3-like isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.


ensembl_gene_id: A0A2U3ZNF2
symbol: LOC101363830
gene_biotype: protein_coding
description:
  LOW QUALITY PROTEIN: olfactory receptor 2L13-like; Belongs to the G-protein coupled receptor 1 family.


ensembl_gene_id: A0A2U3ZNF3
symbol: LOC101375963
gene_biotype: protein_coding
description:
  LOW QUALITY PROTEIN: olfactory receptor 10J5-like; Belongs to the G-protein coupled receptor 1 family.


ensembl_gene_id: A0A2U3ZNR0
symbol: LOC101380807
gene_biotype: protein_coding
description:
  Tubulin beta-7 chain-like isoform X1; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family.


ensembl_gene_id: A0A2U3ZNX0
symbol: RER1
gene_biotype: protein_coding
description:
  Protein RER1; Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.


ensembl_gene_id: A0A2U3ZP89
symbol: LOC101372409
gene_biotype: protein_coding
description:
  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP alpha 1 chain; Belongs to the MHC class II family.


ensembl_gene_id: A0A2U3ZPB1
symbol: ST3GAL4
gene_biotype: protein_coding
description:
  CMP-N-acetylneuraminate-beta-galactosamide- alpha-2,3-sialyltransferase 4 isoform X1; Belongs to the glycosyltransferase 29 family.


ensembl_gene_id: A0A2U3ZPC1
symbol: ASIC3
gene_biotype: protein_coding
description:
  Acid-sensing ion channel 3 isoform X1; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.


ensembl_gene_id: A0A2U3ZPK0
symbol: PIK3C2G
gene_biotype: protein_coding
description:
  Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X1; Belongs to the PI3/PI4-kinase family.


ensembl_gene_id: A0A2U3ZPM6
symbol: BGN
gene_biotype: protein_coding
description:
  Biglycan; May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.


ensembl_gene_id: A0A2U3ZPP1
symbol: PTK7
gene_biotype: protein_coding
description:
  Inactive tyrosine-protein kinase 7 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family.


ensembl_gene_id: A0A2U3ZPU1
symbol: DNMT3B
gene_biotype: protein_coding
description:
  DNA (Cytosine-5)-methyltransferase 3B isoform X1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.


ensembl_gene_id: A0A2U3ZPU9
symbol: PIF1
gene_biotype: protein_coding
description:
  ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...]


ensembl_gene_id: A0A2U3ZPV8
symbol: DNTT
gene_biotype: protein_coding
description:
  DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator.


ensembl_gene_id: A0A2U3ZPY4
symbol: TSEN34
gene_biotype: protein_coding
description:
  tRNA-splicing endonuclease subunit Sen34; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structura [...]


ensembl_gene_id: A0A2U3ZQ56
symbol: ADGRF1
gene_biotype: protein_coding
description:
  Probable G-protein coupled receptor 110 isoform X1; Belongs to the G-protein coupled receptor 2 family.


ensembl_gene_id: A0A2U3ZQ93
symbol: CTU1
gene_biotype: protein_coding
description:
  Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position; Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.


ensembl_gene_id: A0A2U3ZQC3
symbol: B2M
gene_biotype: protein_coding
description:
  Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.


ensembl_gene_id: A0A2U3ZQH1
symbol: NAE1
gene_biotype: protein_coding
description:
  NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.


ensembl_gene_id: A0A2U3ZQJ6
symbol: RET
gene_biotype: protein_coding
description:
  Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands.


ensembl_gene_id: A0A2U3ZQS7
symbol: PRMT7
gene_biotype: protein_coding
description:
  Protein arginine N-methyltransferase; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being r [...]


ensembl_gene_id: A0A2U3ZQT3
symbol: ST6GALNAC3
gene_biotype: protein_coding
description:
  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; Belongs to the glycosyltransferase 29 family.


ensembl_gene_id: A0A2U3ZQU8
symbol: MYO5B
gene_biotype: protein_coding
description:
  Unconventional myosin-Vb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.


ensembl_gene_id: A0A2U3ZR30
symbol: TAT
gene_biotype: protein_coding
description:
  Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate.


ensembl_gene_id: A0A2U3ZR42
symbol: MED17
gene_biotype: protein_coding
description:
  Mediator of RNA polymerase II transcription subunit 17; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.


ensembl_gene_id: A0A2U3ZR68
symbol: MSH4
gene_biotype: protein_coding
description:
  LOW QUALITY PROTEIN: mutS protein homolog 4; Belongs to the eukaryotic ribosomal protein eL42 family.


ensembl_gene_id: A0A2U3ZRJ5
symbol: RTEL1
gene_biotype: protein_coding
description:
  Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by  [...]


ensembl_gene_id: A0A2U3ZRK4
symbol: KIF1B
gene_biotype: protein_coding
description:
  Kinesin-like protein KIF1B isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.


ensembl_gene_id: A0A2U3ZRK8
symbol: DHRS3
gene_biotype: protein_coding
description:
  Short-chain dehydrogenase/reductase 3 isoform X1; Belongs to the short-chain dehydrogenases/reductases (SDR) family.


ensembl_gene_id: A0A2U3ZRN8
symbol: MYC
gene_biotype: protein_coding
description:
  Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.


ensembl_gene_id: A0A2U3ZRP6
symbol: OSTC
gene_biotype: protein_coding
description:
  Oligosaccharyltransferase complex subunit; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All s [...]


ensembl_gene_id: A0A2U3ZRP9
symbol: EGF
gene_biotype: protein_coding
description:
  Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.


ensembl_gene_id: A0A2U3ZRR3
symbol: SLC8B1
gene_biotype: protein_coding
description:
  Sodium/potassium/calcium exchanger 6, mitochondrial; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.


ensembl_gene_id: A0A2U3ZRT7
symbol: PPIP5K1
gene_biotype: protein_coding
description:
  Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates  [...]


ensembl_gene_id: A0A2U3ZRU4
symbol: SURF1
gene_biotype: protein_coding
description:
  SURF1-like protein; Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. Belongs to the SURF1 family.


ensembl_gene_id: A0A2U3ZRW7
symbol: ACLY
gene_biotype: protein_coding
description:
  ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.


ensembl_gene_id: A0A2U3ZS03
symbol: SDHA
gene_biotype: protein_coding
description:
  Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).


ensembl_gene_id: A0A2U3ZS08
symbol: KCNK16
gene_biotype: protein_coding
description:
  Potassium channel subfamily K member 16 isoform X1; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.


ensembl_gene_id: A0A2U3ZSF9
symbol: LOC101373960
gene_biotype: protein_coding
description:
  LOW QUALITY PROTEIN: olfactory receptor-like protein OLF1; Belongs to the G-protein coupled receptor 1 family.


ensembl_gene_id: A0A2U3ZSG3
symbol: LOC101375410
gene_biotype: protein_coding
description:
  LOW QUALITY PROTEIN: olfactory receptor 5D14-like; Belongs to the G-protein coupled receptor 1 family.


ensembl_gene_id: A0A2U3ZSH2
symbol: LOC101363369
gene_biotype: protein_coding
description:
  LOW QUALITY PROTEIN: olfactory receptor 1009-like; Belongs to the G-protein coupled receptor 1 family.


ensembl_gene_id: A0A2U3ZSL4
symbol: RPSA
gene_biotype: protein_coding
description:
  40S ribosomal protein SA; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits; Belongs to the universal ribosomal protein uS2 family.


ensembl_gene_id: A0A2U3ZST4
symbol: CDC42BPA
gene_biotype: protein_coding
description:
  Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.


ensembl_gene_id: A0A2U3ZSX2
symbol: PRKCD
gene_biotype: protein_coding
description:
  Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.


ensembl_gene_id: A0A2U3ZT30
symbol: DUSP14
gene_biotype: protein_coding
description:
  Dual specificity protein phosphatase 14; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.


ensembl_gene_id: A0A2U3ZT53
symbol: SLC10A7
gene_biotype: protein_coding
description:
  Sodium/bile acid cotransporter; Does not show transport activity towards bile acids or steroid sulfates; Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.


ensembl_gene_id: A0A2U3ZTD0
symbol: LCNL1
gene_biotype: protein_coding
description:
  LOW QUALITY PROTEIN: lipocalin-like 1 protein; Belongs to the calycin superfamily. Lipocalin family.


ensembl_gene_id: A0A2U3ZTG6
symbol: MTAP
gene_biotype: protein_coding
description:
  S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.


ensembl_gene_id: A0A2U3ZTJ4
symbol: ST14
gene_biotype: protein_coding
description:
  Suppressor of tumorigenicity 14 protein homolog; Degrades extracellular matrix. Belongs to the peptidase S1 family.


ensembl_gene_id: A0A2U3ZTN2
symbol: ST3GAL6
gene_biotype: protein_coding
description:
  Type 2 lactosamine alpha-2,3-sialyltransferase isoform X1; Belongs to the glycosyltransferase 29 family.


ensembl_gene_id: A0A2U3ZTY7
symbol: MRE11A
gene_biotype: protein_coding
description:
  Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.


